PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33193545-3 2020 MYB12, a subgroup 6 member of R2R3-MYB that positively regulates anthocyanin biosynthesis, is downregulated in the lower halves. Anthocyanins 65-76 MYB proto-oncogene, transcription factor Homo sapiens 0-3 33048534-6 2020 Our results suggest that this new anthocyanidin/anthocyanin fluorescence may be an indicator of oxidation, especially of food products, where these compounds are present or added as colorants, and can also be useful to detect oxidation in biomedical experiments. Anthocyanins 34-47 DDB1 and CUL4 associated factor 7 Homo sapiens 48-59 33059448-6 2020 Inhibiting the expression of HMGR promoted the accumulation of anthocyanins and fruit coloration. Anthocyanins 63-75 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 29-33 33120878-1 2020 Dihydroflavonol 4-reductase (DFR) catalyzes a committed step in anthocyanin and proanthocyanidin biosynthesis by reducing dihydroflavonols to leucoanthocyanidins. Anthocyanins 64-75 dihydroflavonol 4-reductase Arabidopsis thaliana 29-32 33120878-1 2020 Dihydroflavonol 4-reductase (DFR) catalyzes a committed step in anthocyanin and proanthocyanidin biosynthesis by reducing dihydroflavonols to leucoanthocyanidins. Anthocyanins 142-161 dihydroflavonol 4-reductase Arabidopsis thaliana 29-32 33114190-9 2020 GSPE and anthocyanins modulated the lipid content and downregulated the gene and protein levels of Fasn compared to the untreated group in 3T3-L1 cells. Anthocyanins 9-21 fatty acid synthase Mus musculus 99-103 33149809-8 2020 Although NRF2 positively correlated with SIRT3 activation (p < 0.05), only resveratrol (p < 0.01) and anthocyanidin (p < 0.05) could activate NRF2 significantly. Anthocyanins 102-115 NFE2 like bZIP transcription factor 2 Homo sapiens 142-146 33149809-9 2020 Solely anthocyanidin 50 muM (p < 0.05) and 100 muM (p < 0.01) and EGCG 50 muM (p < 0.01) could increase SIRT3 expression. Anthocyanins 7-20 sirtuin 3 Homo sapiens 104-109 33059637-4 2020 The inhibitory pathway of anthocyanin was explored by assessment of tumour cell mitochondrial membrane potential (MMP), the caspase-3 and caspase-9 activity, as well as the cell energy metabolism in terms of the glucose uptake, the NAD+/NADH ratio and the ATP level. Anthocyanins 26-37 caspase 3 Mus musculus 124-133 33059637-4 2020 The inhibitory pathway of anthocyanin was explored by assessment of tumour cell mitochondrial membrane potential (MMP), the caspase-3 and caspase-9 activity, as well as the cell energy metabolism in terms of the glucose uptake, the NAD+/NADH ratio and the ATP level. Anthocyanins 26-37 caspase 9 Mus musculus 138-147 33066504-4 2020 As shown by intervention studies on volunteers, the most promising candidates for improving insulin resistance are (-)-epicatechin, (-)-epicatechin-containing foods and anthocyanins. Anthocyanins 169-181 insulin Homo sapiens 92-99 33049148-3 2021 In this paper, we have discovered that Cyanidin-3-O-glucoside (C3G), which is one of the anthocyanins, could alleviate high glucose induced podocytes dysfunction. Anthocyanins 89-101 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 63-66 32686829-0 2020 Blueberry MIR156a/SPL12 module coordinates the accumulation of chlorophylls and anthocyanins during fruit ripening. Anthocyanins 80-92 MIR156a Solanum lycopersicum 10-17 33021853-2 2020 Anthocyanins possess health promoting properties mainly associated to the induction of Nrf2-regulated cytoprotective proteins. Anthocyanins 0-12 NFE2 like bZIP transcription factor 2 Homo sapiens 87-91 33021853-6 2020 DISCUSSION AND CONCLUSION: Results suggest that anti-inflammatory properties of anthocyanins, mediated by Nrf2, could represent an interesting tool for intestinal inflammatory disorders. Anthocyanins 80-92 NFE2 like bZIP transcription factor 2 Homo sapiens 106-110 33110987-4 2020 We report here that hybrid pigments with improved thermal stability, fluorescence, and attractive colors are produced by the cation-exchange-mediated adsorption of flavylium cations (FL) on two synthetic clays, the mica-montmorillonite SYn-1, and the laponite SYnL-1. Anthocyanins 164-173 synapsin I Homo sapiens 236-241 32855168-2 2020 Using RNA-sequencing analysis of a cross between diploid potato (Solanum tuberosum L.) lines segregating for flower color, we identified a homolog of the ANTHOCYANIN 2 (AN2) gene family that encodes a MYB transcription factor, herein termed StFlAN2, as the regulator of anthocyanin production in potato corollas. Anthocyanins 270-281 AN2 Solanum tuberosum 154-167 32855168-2 2020 Using RNA-sequencing analysis of a cross between diploid potato (Solanum tuberosum L.) lines segregating for flower color, we identified a homolog of the ANTHOCYANIN 2 (AN2) gene family that encodes a MYB transcription factor, herein termed StFlAN2, as the regulator of anthocyanin production in potato corollas. Anthocyanins 270-281 AN2 Solanum tuberosum 169-172 32396017-10 2020 Therefore, anthocyanin-rich blackcurrants might be beneficial for maintaining or improving cardiovascular health as an alternative to pharmaceutical medications.Abbreviations: Aix: augmentation index; BP: blood pressure; cfPWV: carotid-femoral pulse-wave velocity; CVD: cardiovascular diseases; DBP: diastolic blood pressure; faPWV: femoral-ankle pulse-wave velocity; FG: fasting glucose; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol; MBP: mean blood pressure; NZBC: New Zealand blackcurrant; PP: pulse pressure; SBP: systolic blood pressure; TG: triglycerides. Anthocyanins 11-22 D-box binding PAR bZIP transcription factor Homo sapiens 296-299 32396017-10 2020 Therefore, anthocyanin-rich blackcurrants might be beneficial for maintaining or improving cardiovascular health as an alternative to pharmaceutical medications.Abbreviations: Aix: augmentation index; BP: blood pressure; cfPWV: carotid-femoral pulse-wave velocity; CVD: cardiovascular diseases; DBP: diastolic blood pressure; faPWV: femoral-ankle pulse-wave velocity; FG: fasting glucose; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol; MBP: mean blood pressure; NZBC: New Zealand blackcurrant; PP: pulse pressure; SBP: systolic blood pressure; TG: triglycerides. Anthocyanins 11-22 myelin basic protein Homo sapiens 476-479 33083375-0 2020 Investigation of Anthocyanidins and Anthocyanins for Targeting alpha-Glucosidase in Diabetes Mellitus. Anthocyanins 17-31 sucrase-isomaltase Homo sapiens 63-80 32430240-0 2020 Pomegranate-derived anthocyanin regulates MORs-cAMP/CREB-BDNF pathways in opioid-dependent models and improves cognitive impairments. Anthocyanins 20-31 cAMP responsive element binding protein 1 Rattus norvegicus 52-56 32430240-0 2020 Pomegranate-derived anthocyanin regulates MORs-cAMP/CREB-BDNF pathways in opioid-dependent models and improves cognitive impairments. Anthocyanins 20-31 brain-derived neurotrophic factor Rattus norvegicus 57-61 32854072-5 2020 The cbl1 mutant exhibited a relatively tolerant phenotype, with longer roots, lower anthocyanin content, and elevated Pi content under Pi deficiency, and a more sensitive phenotype to arsenate treatment compared with wild-type plants. Anthocyanins 84-95 calcineurin B-like protein 1 Arabidopsis thaliana 4-8 33083375-0 2020 Investigation of Anthocyanidins and Anthocyanins for Targeting alpha-Glucosidase in Diabetes Mellitus. Anthocyanins 36-48 sucrase-isomaltase Homo sapiens 63-80 33083375-3 2020 However, limited information is available regarding the inhibitory effect and interactions of anthocyanidins on alpha-glucosidase, the key enzyme that controls diabetes through degrading carbohydrate. Anthocyanins 94-108 sucrase-isomaltase Homo sapiens 112-129 33083375-5 2020 The results suggested that anthocyanidins exhibit half maximal inhibitory concentration of 4~55 muM; the strongest and weakest alpha-glucosidase inhibitors were delphinidin and malvidin, respectively. Anthocyanins 27-41 sucrase-isomaltase Homo sapiens 127-144 32993050-0 2020 MOS1 Negatively Regulates Sugar Responses and Anthocyanin Biosynthesis in Arabidopsis. Anthocyanins 46-57 ARM repeat superfamily protein Arabidopsis thaliana 0-4 32999301-6 2020 The stronger expression level of F3H, the key enzyme in flavonoid biosynthesis in plants, (588.133-fold) and AN2, anthocyanin 2 transcription factor, (97.005-fold) suggested that the accumulation flavonoid, especially anthocyanin, might play significant roles in plant defense against viral infection. Anthocyanins 114-125 AN2 Solanum tuberosum 109-112 33061500-0 2020 Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial. Anthocyanins 10-22 insulin like growth factor binding protein 4 Homo sapiens 48-55 33061500-3 2020 The aim of this study was to examine the effects of purified anthocyanins on serum IGFBP-4 fragments and glycemic control in patients with fasting hyperglycemia. Anthocyanins 61-73 insulin like growth factor binding protein 4 Homo sapiens 83-90 33061500-8 2020 Conclusion: Anthocyanins supplementation for 12 weeks improved serum IGFBP-4 fragments and decreased fasting glucose and postload C-peptide in patients with fasting hyperglycemia. Anthocyanins 12-24 insulin like growth factor binding protein 4 Homo sapiens 69-76 33061500-8 2020 Conclusion: Anthocyanins supplementation for 12 weeks improved serum IGFBP-4 fragments and decreased fasting glucose and postload C-peptide in patients with fasting hyperglycemia. Anthocyanins 12-24 insulin Homo sapiens 130-139 32993050-8 2020 Furthermore, the mos1 mutant accumulated more anthocyanin than did wild-type Col-0 when grown on high-sugar concentration medium or under high light. Anthocyanins 46-57 modifier of snc1 Arabidopsis thaliana 17-21 32993050-9 2020 MOS1 was found to regulate the expression of flavonoid and anthocyanin biosynthetic genes in response to exogenous sucrose and high-light stress but with different underlying mechanisms, showing multiple functions in addition to immunity regulation in plant development. Anthocyanins 59-70 ARM repeat superfamily protein Arabidopsis thaliana 0-4 32973912-0 2020 Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial. Anthocyanins 0-12 adiponectin, C1Q and collagen domain containing Homo sapiens 28-39 32973912-2 2020 This study first examined the effect of purified anthocyanins, a group of dietary flavonoids, on serum adiponectin in patients with prediabetes and newly diagnosed diabetes. Anthocyanins 49-61 adiponectin, C1Q and collagen domain containing Homo sapiens 103-114 32973912-5 2020 Results: Anthocyanins increased serum adiponectin compared with placebo (net change 0.46 microg/mL, 95% CI [0.03, 0.90], p = 0.038) in the subjects with newly diagnosed diabetes. Anthocyanins 9-21 adiponectin, C1Q and collagen domain containing Homo sapiens 38-49 32973912-8 2020 Conclusions: Anthocyanins supplementation for 12 weeks improved serum adiponectin and fasting glucose in patients with newly diagnosed diabetes, but not in patients with prediabetes. Anthocyanins 13-25 adiponectin, C1Q and collagen domain containing Homo sapiens 70-81 32948821-1 2020 We demonstrate the mechanism by which C3G, a major dietary anthocyanin, regulates energy metabolism and insulin sensitivity. Anthocyanins 59-70 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 38-41 32924599-0 2021 Dark Sweet Cherry (Prunus avium) Phenolics Enriched in Anthocyanins Induced Apoptosis in MDA-MB-453 Breast Cancer Cells through MAPK-Dependent Signaling and Reduced Invasion via Akt and PLCgamma-1 Downregulation. Anthocyanins 55-67 AKT serine/threonine kinase 1 Homo sapiens 178-181 32924599-0 2021 Dark Sweet Cherry (Prunus avium) Phenolics Enriched in Anthocyanins Induced Apoptosis in MDA-MB-453 Breast Cancer Cells through MAPK-Dependent Signaling and Reduced Invasion via Akt and PLCgamma-1 Downregulation. Anthocyanins 55-67 phospholipase C gamma 1 Homo sapiens 186-196 32920547-10 2020 These findings suggest that R. meyeri anthocyanins increase NSC proliferation and improve neurogenesis with aging via Nar-induced reductions in TNF-alpha protein levels in vivo. Anthocyanins 38-50 tumor necrosis factor Mus musculus 144-153 32724997-2 2020 This reaction took advantage of cycloisomerization of 2-hydroxychalcone to form a transient flavylium under the irradiation of 24 W CFL, which was trapped by the in situ generated chiral enamine intermediate. Anthocyanins 92-101 cofilin 1 Homo sapiens 132-135 32894038-5 2020 Transcriptome analysis showed that the coordinately down-regulated anthocyanin biosynthetic genes including chalcone isomerase, naringenin 3-dioxygenase, dihydroflavonol 4-reductase and UDP-glucose:flavonoid 3-O-glucosyltransferase played critical roles in suppressing the formation of the aforesaid anthocyanins. Anthocyanins 67-78 dihydroflavonol-4-reductase Nicotiana tabacum 154-181 32894038-5 2020 Transcriptome analysis showed that the coordinately down-regulated anthocyanin biosynthetic genes including chalcone isomerase, naringenin 3-dioxygenase, dihydroflavonol 4-reductase and UDP-glucose:flavonoid 3-O-glucosyltransferase played critical roles in suppressing the formation of the aforesaid anthocyanins. Anthocyanins 300-312 dihydroflavonol-4-reductase Nicotiana tabacum 154-181 32762648-3 2020 We cloned and analyzed the glutathione S-transferases (GSTs) in Japanese gentian that are known to be involved in anthocyanin transport in other plant species. Anthocyanins 114-125 glutathione S-transferase mu 1 Homo sapiens 55-59 32993165-5 2020 Based on differentially expressed gene analysis, we found that ectopic expression of PAP1 induced the expression of genes involved in the "phenylpropanoid biosynthesis" (24 genes), and "flavonoid biosynthesis" (17 genes) pathways, resulting in 191- to 341-fold increases in anthocyanin production compared to transgenic control (TC) hairy roots. Anthocyanins 274-285 PDGFA associated protein 1 Mus musculus 85-89 32993165-9 2020 Taken together, our results suggested that the ectopic expression of PAP1 is an effective strategy for the enhancement of anthocyanin production, which improves the biological activities of ginseng root cultures. Anthocyanins 122-133 PDGFA associated protein 1 Mus musculus 69-73 32899830-10 2020 It was revealed that ADE standardized to 25% of anthocyanins depresses the level of markers of inflammation and lipid peroxidation (Interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and malondialdehyde (MDA)) in in vitro conditions. Anthocyanins 48-60 interleukin 1 beta Homo sapiens 132-150 32899830-10 2020 It was revealed that ADE standardized to 25% of anthocyanins depresses the level of markers of inflammation and lipid peroxidation (Interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and malondialdehyde (MDA)) in in vitro conditions. Anthocyanins 48-60 interleukin 1 alpha Homo sapiens 152-160 32899830-10 2020 It was revealed that ADE standardized to 25% of anthocyanins depresses the level of markers of inflammation and lipid peroxidation (Interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and malondialdehyde (MDA)) in in vitro conditions. Anthocyanins 48-60 tumor necrosis factor Homo sapiens 163-190 32899830-10 2020 It was revealed that ADE standardized to 25% of anthocyanins depresses the level of markers of inflammation and lipid peroxidation (Interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and malondialdehyde (MDA)) in in vitro conditions. Anthocyanins 48-60 tumor necrosis factor Homo sapiens 192-201 32684465-7 2020 Specifically, various stronger positive correlations were noted for anthocyanin composition and UFA (pelargonidin and petunidin with C14:1n-5, C17:1n-7, C18:2n-6, C20:2n-6, C20:3n-3, and C20:4n-6; and cyanidin and total anthocyanins with C14:1n-5, C16:1n-7, C17:1n-7). Anthocyanins 68-79 cytokine like 1 Homo sapiens 143-146 32684465-7 2020 Specifically, various stronger positive correlations were noted for anthocyanin composition and UFA (pelargonidin and petunidin with C14:1n-5, C17:1n-7, C18:2n-6, C20:2n-6, C20:3n-3, and C20:4n-6; and cyanidin and total anthocyanins with C14:1n-5, C16:1n-7, C17:1n-7). Anthocyanins 68-79 Bardet-Biedl syndrome 9 Homo sapiens 153-156 32684465-7 2020 Specifically, various stronger positive correlations were noted for anthocyanin composition and UFA (pelargonidin and petunidin with C14:1n-5, C17:1n-7, C18:2n-6, C20:2n-6, C20:3n-3, and C20:4n-6; and cyanidin and total anthocyanins with C14:1n-5, C16:1n-7, C17:1n-7). Anthocyanins 68-79 cytokine like 1 Homo sapiens 258-261 32669036-1 2020 Strigolactone and karrikin receptors, DWARF14 (D14) and KARRIKIN INSENSITIVE 2 (KAI2), respectively, have been shown to positively regulate drought resistance in Arabidopsis thaliana by modulating abscisic acid responsiveness, anthocyanin accumulation, stomatal closure, cell membrane integrity and cuticle formation. Anthocyanins 227-238 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 38-45 32669036-1 2020 Strigolactone and karrikin receptors, DWARF14 (D14) and KARRIKIN INSENSITIVE 2 (KAI2), respectively, have been shown to positively regulate drought resistance in Arabidopsis thaliana by modulating abscisic acid responsiveness, anthocyanin accumulation, stomatal closure, cell membrane integrity and cuticle formation. Anthocyanins 227-238 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 56-78 32669036-1 2020 Strigolactone and karrikin receptors, DWARF14 (D14) and KARRIKIN INSENSITIVE 2 (KAI2), respectively, have been shown to positively regulate drought resistance in Arabidopsis thaliana by modulating abscisic acid responsiveness, anthocyanin accumulation, stomatal closure, cell membrane integrity and cuticle formation. Anthocyanins 227-238 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 80-84 32738704-4 2020 Light induces the expression of transportation factor genes MYB10, WD40, and HY5, which then activate the expression of critical genes in the anthocyanin biosynthesis pathway to promote the synthesis and accumulation of anthocyanin, thus giving the red coloration. Anthocyanins 142-153 myb domain protein 10 Arabidopsis thaliana 60-65 32738704-4 2020 Light induces the expression of transportation factor genes MYB10, WD40, and HY5, which then activate the expression of critical genes in the anthocyanin biosynthesis pathway to promote the synthesis and accumulation of anthocyanin, thus giving the red coloration. Anthocyanins 142-153 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 77-80 32738704-4 2020 Light induces the expression of transportation factor genes MYB10, WD40, and HY5, which then activate the expression of critical genes in the anthocyanin biosynthesis pathway to promote the synthesis and accumulation of anthocyanin, thus giving the red coloration. Anthocyanins 220-231 myb domain protein 10 Arabidopsis thaliana 60-65 32738704-4 2020 Light induces the expression of transportation factor genes MYB10, WD40, and HY5, which then activate the expression of critical genes in the anthocyanin biosynthesis pathway to promote the synthesis and accumulation of anthocyanin, thus giving the red coloration. Anthocyanins 220-231 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 77-80 32738704-5 2020 Protein HY5 is considered to be a key regulator for induction of anthocyanin biosynthesis. Anthocyanins 65-76 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 8-11 32738704-6 2020 The MYB10 genes physically interact with HY5 to positively regulate anthocyanin biosynthesis in Arabidopsis, apple, and pear by binding to G-box motifs. Anthocyanins 68-79 myb domain protein 10 Arabidopsis thaliana 4-9 32738704-6 2020 The MYB10 genes physically interact with HY5 to positively regulate anthocyanin biosynthesis in Arabidopsis, apple, and pear by binding to G-box motifs. Anthocyanins 68-79 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 41-44 32771154-9 2020 This transcription factor can interact with bHLHs belonging to the MBW (R2R3-MYB, bHLH and WD40) anthocyanin activator complex and, potentially, may interfere with its formation. Anthocyanins 97-108 transcription factor TT8-like Solanum tuberosum 44-48 32771154-9 2020 This transcription factor can interact with bHLHs belonging to the MBW (R2R3-MYB, bHLH and WD40) anthocyanin activator complex and, potentially, may interfere with its formation. Anthocyanins 97-108 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 91-95 32843672-3 2020 In this study, transcriptomic analysis of purple-pigmented kiwifruit skin and flesh tissues identified MYBC1, from subgroup 5 of the R2R3 MYB family, and WRKY44 (highly similar to Arabidopsis TTG2) as candidate activators of the anthocyanin pathway. Anthocyanins 229-240 WRKY family transcription factor family protein Arabidopsis thaliana 192-196 32842576-0 2020 Isolation and Analysis of Anthocyanin Pathway Genes from Ribes Genus Reveals MYB Gene with Potent Anthocyanin-Inducing Capabilities. Anthocyanins 26-37 uncharacterized protein LOC107775040 Nicotiana tabacum 77-80 32842576-0 2020 Isolation and Analysis of Anthocyanin Pathway Genes from Ribes Genus Reveals MYB Gene with Potent Anthocyanin-Inducing Capabilities. Anthocyanins 98-109 uncharacterized protein LOC107775040 Nicotiana tabacum 77-80 32842576-5 2020 Functional tests showed a strong capability of RrMyb10 to induce anthocyanin synthesis in a heterologous system, even without the concurrent expression of any heterologous bHLH, whereas RrbHLH3 enhanced MYB-induced anthocyanin synthesis. Anthocyanins 215-226 uncharacterized protein LOC107775040 Nicotiana tabacum 203-206 32943841-1 2020 Background: Cyanidin-3-O-glucoside (C3G) is an important anthocyanin that can modulate digestive system functioning. Anthocyanins 57-68 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 36-39 32973819-1 2020 Here, we demonstrate that BnaPAP2.A7, an ortholog of the B. oleracea anthocyanin activator BoMYB2 that confers purple traits, positively regulates anthocyanin biosynthesis in leaves of B. napus. Anthocyanins 69-80 transcription factor MYB114-like Brassica oleracea 91-97 32973819-1 2020 Here, we demonstrate that BnaPAP2.A7, an ortholog of the B. oleracea anthocyanin activator BoMYB2 that confers purple traits, positively regulates anthocyanin biosynthesis in leaves of B. napus. Anthocyanins 147-158 transcription factor MYB114-like Brassica oleracea 91-97 32784919-0 2020 Anthocyanins Isolated from Vitis coignetiae Pulliat Enhances Cisplatin Sensitivity in MCF-7 Human Breast Cancer Cells through Inhibition of Akt and NF-kappaB Activation. Anthocyanins 0-12 AKT serine/threonine kinase 1 Homo sapiens 140-143 32784919-0 2020 Anthocyanins Isolated from Vitis coignetiae Pulliat Enhances Cisplatin Sensitivity in MCF-7 Human Breast Cancer Cells through Inhibition of Akt and NF-kappaB Activation. Anthocyanins 0-12 nuclear factor kappa B subunit 1 Homo sapiens 148-157 32784919-1 2020 Anthocyanins isolated from Vitis coignetiae Pulliat (Meoru in Korea) (AIMs) have various anti-cancer properties by inhibiting Akt and NF-kappaB which are involved in drug resistance. Anthocyanins 0-12 AKT serine/threonine kinase 1 Homo sapiens 126-129 32762648-10 2020 In the GST1 genome-edited lines, sugar-induced stress conditions inhibited the accumulation of anthocyanins in stems and leaves, suggestvhing that GST1 is necessary for stress-related anthocyanin accumulation in organs other than flowers. Anthocyanins 95-107 glutathione S-transferase mu 1 Homo sapiens 7-11 32762648-10 2020 In the GST1 genome-edited lines, sugar-induced stress conditions inhibited the accumulation of anthocyanins in stems and leaves, suggestvhing that GST1 is necessary for stress-related anthocyanin accumulation in organs other than flowers. Anthocyanins 95-107 glutathione S-transferase mu 1 Homo sapiens 147-151 32762648-10 2020 In the GST1 genome-edited lines, sugar-induced stress conditions inhibited the accumulation of anthocyanins in stems and leaves, suggestvhing that GST1 is necessary for stress-related anthocyanin accumulation in organs other than flowers. Anthocyanins 95-106 glutathione S-transferase mu 1 Homo sapiens 7-11 32762648-10 2020 In the GST1 genome-edited lines, sugar-induced stress conditions inhibited the accumulation of anthocyanins in stems and leaves, suggestvhing that GST1 is necessary for stress-related anthocyanin accumulation in organs other than flowers. Anthocyanins 95-106 glutathione S-transferase mu 1 Homo sapiens 147-151 32762648-11 2020 These observations clearly demonstrate that GST1 is the gene responsible for anthocyanin transport in Japanese gentian, and is necessary for the accumulation of gentiodelphin in flowers. Anthocyanins 77-88 glutathione S-transferase mu 1 Homo sapiens 44-48 32640796-9 2020 In conclusion, C3G protected against high glucose-induced SRA01/04 cell apoptosis and cataract formation, which indicated the potential protection of anthocyanins on diabetic cataract. Anthocyanins 150-162 Rap guanine nucleotide exchange factor 1 Homo sapiens 15-18 32821401-0 2020 MiR156 regulates anthocyanin biosynthesis through SPL targets and other microRNAs in poplar. Anthocyanins 17-28 sphingosine-1-phosphate lyase 1 Homo sapiens 50-53 32764272-7 2020 Quantitative real time PCR and HPLC analysis of leaf and berry samples showed that the GCE repeat number strongly correlates with an increase of the expression of VvmybA1 itself and the VvUFGT gene regulated by it and the anthocyanin content. Anthocyanins 222-233 transcription factor MYB90 Vitis vinifera 163-170 32764272-7 2020 Quantitative real time PCR and HPLC analysis of leaf and berry samples showed that the GCE repeat number strongly correlates with an increase of the expression of VvmybA1 itself and the VvUFGT gene regulated by it and the anthocyanin content. Anthocyanins 222-233 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 186-192 32821401-4 2020 Here, we overexpressed miR156 in poplar to study the comprehensive effects of the miR156-SPL module on the biosynthesis of anthocyanins. Anthocyanins 123-135 sphingosine-1-phosphate lyase 1 Homo sapiens 89-92 32821401-6 2020 Furthermore, integrated microRNAomic and transcriptomic analysis suggested that two microRNAs, miR160h, and miR858, have the potential to affect anthocyanin accumulation in poplar by regulating auxin response factors and MYB transcription factors, respectively. Anthocyanins 145-156 MYB proto-oncogene, transcription factor Homo sapiens 221-224 32528176-4 2020 Here we use a synthetic strigolactone to identify 401 strigolactone-responsive genes in Arabidopsis, and show that these plant hormones regulate shoot branching, leaf shape and anthocyanin accumulation mainly through transcriptional activation of the BRANCHED 1, TCP DOMAIN PROTEIN 1 and PRODUCTION OF ANTHOCYANIN PIGMENT 1 genes. Anthocyanins 177-188 TCP family transcription factor Arabidopsis thaliana 251-261 32146312-0 2020 Fluorescence spectroscopy and molecular modeling of anthocyanins binding to bovine lactoferrin peptides. Anthocyanins 52-64 lactotransferrin Bos taurus 83-94 32146312-1 2020 This work was aimed to obtain lactoferrin peptides, with anthocyanins-binding capabilities, by using eggplant peels extract as a source of anthocyanins. Anthocyanins 57-69 lactotransferrin Bos taurus 30-41 32146312-1 2020 This work was aimed to obtain lactoferrin peptides, with anthocyanins-binding capabilities, by using eggplant peels extract as a source of anthocyanins. Anthocyanins 139-151 lactotransferrin Bos taurus 30-41 32647533-4 2020 The reporter gene AtMyb75 in Arabidopsis, encoding an R2R3 type MYB transcription factor, was ectopically expressed in hairy roots-mediated by A. rhizogenes, which induced purple/red colored anthocyanin accumulation in crop species like soybean (Glycine max (L.) Merr.) Anthocyanins 191-202 production of anthocyanin pigment 1 Arabidopsis thaliana 18-25 32086122-7 2020 Computational studies were performed to evaluate the interaction between anthocyanins and glucose gastric transporters GLUT1 and GLUT3, which supported the experimental findings. Anthocyanins 73-85 solute carrier family 2 member 1 Homo sapiens 119-124 32086122-7 2020 Computational studies were performed to evaluate the interaction between anthocyanins and glucose gastric transporters GLUT1 and GLUT3, which supported the experimental findings. Anthocyanins 73-85 solute carrier family 2 member 3 Homo sapiens 129-134 32022953-2 2020 In this study, loss-of-function analysis of the D14 gene in Arabidopsis thaliana revealed that d14 mutant plants were more drought-susceptible than wild-type, which was associated with their larger stomatal aperture, slower abscisic acid (ABA)-mediated stomatal closure, lower anthocyanin content and delayed senescence under drought stress. Anthocyanins 277-288 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 48-51 32022953-2 2020 In this study, loss-of-function analysis of the D14 gene in Arabidopsis thaliana revealed that d14 mutant plants were more drought-susceptible than wild-type, which was associated with their larger stomatal aperture, slower abscisic acid (ABA)-mediated stomatal closure, lower anthocyanin content and delayed senescence under drought stress. Anthocyanins 277-288 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 95-98 32022953-6 2020 On the other hand, D14 had a lesser role in the maintenance of cell membrane integrity and leaf cuticle structure, and ABA-induced leaf senescence; but a greater role in drought-induced anthocyanin biosynthesis than KAI2. Anthocyanins 186-197 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 19-22 32610673-7 2020 Together with the finding of significantly stronger accumulation of anthocyanins under heat/high light, these observations indicate a central role of hexokinase activity in the stabilization of photosynthesis and carbohydrate metabolism during environmental changes. Anthocyanins 68-80 hexokinase Arabidopsis thaliana 150-160 32354877-4 2020 We demonstrated that blocking endogenous melatonin biosynthesis by knocking out SNAT1 and/or COMT significantly increased oil and anthocyanin content of mature seeds. Anthocyanins 130-141 O-methyltransferase 1 Arabidopsis thaliana 93-97 32354877-6 2020 Further gene expression analysis through RNA-sequencing and reverse transcription quantitative PCR demonstrated that the expression of a series of important genes involved in fatty acid and anthocyanin accumulation was significantly altered in snat1-1 comt-1 developing seeds during seed maturation. Anthocyanins 190-201 O-methyltransferase 1 Arabidopsis thaliana 252-258 32007662-0 2020 Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways. Anthocyanins 39-51 sirtuin 1 Mus musculus 108-113 32415123-4 2020 We show that mutations in RDR6, SGS3, or DCL4 suppress the anthocyanin defect of tt19 by pushing carbon towards flavonoid biosynthesis. Anthocyanins 59-70 RNA-dependent RNA polymerase 6 Arabidopsis thaliana 26-30 32415123-4 2020 We show that mutations in RDR6, SGS3, or DCL4 suppress the anthocyanin defect of tt19 by pushing carbon towards flavonoid biosynthesis. Anthocyanins 59-70 XS domain-containing protein / XS zinc finger domain-containing protein-like protein Arabidopsis thaliana 32-36 32415123-4 2020 We show that mutations in RDR6, SGS3, or DCL4 suppress the anthocyanin defect of tt19 by pushing carbon towards flavonoid biosynthesis. Anthocyanins 59-70 dicer-like 4 Arabidopsis thaliana 41-45 32457776-9 2020 The up-regulated expression of VvMYBA1 on chromosome 2 and VvMYBA5, VvMYBA6, and VvMYBA7 on chromosome 14 are responsible for the anthocyanin patterns of Yan73 vegetative tissues. Anthocyanins 130-141 MYBA1 Vitis vinifera 31-38 32457776-9 2020 The up-regulated expression of VvMYBA1 on chromosome 2 and VvMYBA5, VvMYBA6, and VvMYBA7 on chromosome 14 are responsible for the anthocyanin patterns of Yan73 vegetative tissues. Anthocyanins 130-141 transcription factor MYB90 Vitis vinifera 68-75 32457776-9 2020 The up-regulated expression of VvMYBA1 on chromosome 2 and VvMYBA5, VvMYBA6, and VvMYBA7 on chromosome 14 are responsible for the anthocyanin patterns of Yan73 vegetative tissues. Anthocyanins 130-141 R2R3 MYB transcription factor Vitis vinifera 81-88 32784919-1 2020 Anthocyanins isolated from Vitis coignetiae Pulliat (Meoru in Korea) (AIMs) have various anti-cancer properties by inhibiting Akt and NF-kappaB which are involved in drug resistance. Anthocyanins 0-12 nuclear factor kappa B subunit 1 Homo sapiens 134-143 32149350-1 2020 In planta, a vital regulatory complex MYB-basic helix-loop-helix (bHLH)-WD40 (MBW), is involved in the trichome development, synthesis of anthocyanin and proanthocyanin. Anthocyanins 138-149 uncharacterized protein LOC107909337 Gossypium hirsutum 38-41 32560581-11 2020 As a result, light-induced down-regulation of BrmiR828 can target BrTAS4, BrPAP1 (Bra039763), MYB82 (Bra022602) to negatively regulate their transcript levels leading to the accumulation of MYB transcription factors that positively regulate anthocyanin biosynthesis in light-exposed seedlings of Brassica rapa. Anthocyanins 241-252 myb domain protein 82 Arabidopsis thaliana 94-99 32528695-4 2020 In vitro and in vivo assays showed that MYBA-bHLH3-TTG1 regulates the biosynthesis of anthocyanins, while TT2L1 and TT2L2 work with bHLH3 or GL3 and form a MYB-bHLH-WD40 (MBW) complex with TTG1 to regulate proanthocyanidin (PA) synthesis. Anthocyanins 86-98 LIM domain only 1 Homo sapiens 51-55 32278858-8 2020 Logarithmically adjusted plasma interleukin-10 levels were negatively correlated with increasing anthocyanin dose (F = 2.738, P = 0.025). Anthocyanins 97-108 interleukin 10 Homo sapiens 32-46 32163155-9 2020 atsuc1 loss-of-function mutants are defective in sucrose-induced anthocyanin accumulation. Anthocyanins 65-76 sucrose-proton symporter 1 Arabidopsis thaliana 0-6 32163155-12 2020 The results indicate that sucrose uptake via AtSUC1 is required for sucrose-induced AtSUC1 expression and sucrose-induced anthocyanin accumulation and that the site for sucrose detection is intracellular. Anthocyanins 122-133 sucrose-proton symporter 1 Arabidopsis thaliana 45-51 32221665-0 2020 CRISPR/Cas9-mediated SlAN2 mutants reveal various regulatory models of anthocyanin biosynthesis in tomato plant. Anthocyanins 71-82 transcription factor MYB75 Solanum lycopersicum 21-26 32221665-1 2020 KEY MESSAGE: Combining phenotype and gene expression analysis of the CRISPR/Cas9-induced SlAN2 mutants, we revealed that SlAN2 specifically regulated anthocyanin accumulation in vegetative tissues in purple tomato cultivar "Indigo Rose." Anthocyanins 150-161 transcription factor MYB75 Solanum lycopersicum 121-126 32221665-3 2020 The tomato genome contains four highly homologous anthocyanin-related R2R3-MYB transcription factors: SlAN2, SlANT1, SlANT1-like, and SlAN2-like/Aft. Anthocyanins 50-61 transcription factor MYB75 Solanum lycopersicum 102-107 32221665-3 2020 The tomato genome contains four highly homologous anthocyanin-related R2R3-MYB transcription factors: SlAN2, SlANT1, SlANT1-like, and SlAN2-like/Aft. Anthocyanins 50-61 anthocyanin 1 Solanum lycopersicum 109-115 32221665-3 2020 The tomato genome contains four highly homologous anthocyanin-related R2R3-MYB transcription factors: SlAN2, SlANT1, SlANT1-like, and SlAN2-like/Aft. Anthocyanins 50-61 anthocyanin 1 Solanum lycopersicum 117-123 32221665-3 2020 The tomato genome contains four highly homologous anthocyanin-related R2R3-MYB transcription factors: SlAN2, SlANT1, SlANT1-like, and SlAN2-like/Aft. Anthocyanins 50-61 transcription factor MYB75 Solanum lycopersicum 134-139 32221665-4 2020 SlAN2-like/Aft regulates anthocyanin accumulation in the fruit; however, the genetic function of the other three factors remains unclear. Anthocyanins 25-36 transcription factor MYB75 Solanum lycopersicum 0-5 32221665-6 2020 The SlAN2 mutants had a fruit color and anthocyanin content similar to cv. Anthocyanins 40-51 transcription factor MYB75 Solanum lycopersicum 4-9 32221665-7 2020 "Indigo Rose," while the anthocyanin content and the relative expression levels of several anthocyanin-related genes in vegetative tissues were significantly lower in the SlAN2 mutant relative to cv. Anthocyanins 25-36 transcription factor MYB75 Solanum lycopersicum 171-176 32221665-7 2020 "Indigo Rose," while the anthocyanin content and the relative expression levels of several anthocyanin-related genes in vegetative tissues were significantly lower in the SlAN2 mutant relative to cv. Anthocyanins 91-102 transcription factor MYB75 Solanum lycopersicum 171-176 32317363-4 2020 These yield defects correlated with compromised reproductive development predominantly in female tissues, as well as chlorosis, and the accumulation of anthocyanins in cepr1 reproductive tissues. Anthocyanins 152-164 Leucine-rich repeat transmembrane protein kinase family protein Arabidopsis thaliana 168-173 32328868-3 2020 Phosphate, sugar, and UV light are known to regulate anthocyanin accumulation via miR828 and Trans-Acting Small-interfering locus4 (TAS4), specifically in grape by production of phased TAS4a/b/c small-interfering RNAs that are differentially expressed and target MYBA5/6/7 transcription factor transcripts for post-transcriptional slicing and antisense-mediated silencing. Anthocyanins 53-64 tas4a/b/c None 185-194 32328868-3 2020 Phosphate, sugar, and UV light are known to regulate anthocyanin accumulation via miR828 and Trans-Acting Small-interfering locus4 (TAS4), specifically in grape by production of phased TAS4a/b/c small-interfering RNAs that are differentially expressed and target MYBA5/6/7 transcription factor transcripts for post-transcriptional slicing and antisense-mediated silencing. Anthocyanins 53-64 myba5/6/7 None 263-272 31996900-0 2020 Dynamic regulation of different light intensity-modulated anthocyanin biosynthesis by BT2-TCP46-MYB1 in apple. Anthocyanins 58-69 transcription factor MYB86-like Malus domestica 96-100 32514500-0 2020 Consumption of anthocyanin-rich beverages affects Nrf2 and Nrf2-dependent gene transcription in peripheral lymphocytes and DNA integrity of healthy volunteers. Anthocyanins 15-26 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 32514500-0 2020 Consumption of anthocyanin-rich beverages affects Nrf2 and Nrf2-dependent gene transcription in peripheral lymphocytes and DNA integrity of healthy volunteers. Anthocyanins 15-26 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 32514500-9 2020 Consumption of a bolus of anthocyanin-rich beverages affected Nrf2 and Nrf2-dependent gene transcription in human PBL and DNA integrity, which is indicative for systemic effects. Anthocyanins 26-37 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 32514500-9 2020 Consumption of a bolus of anthocyanin-rich beverages affected Nrf2 and Nrf2-dependent gene transcription in human PBL and DNA integrity, which is indicative for systemic effects. Anthocyanins 26-37 NFE2 like bZIP transcription factor 2 Homo sapiens 71-75 32455624-0 2020 Pretreatment of Anthocyanin from the Fruit of Vitis coignetiae Pulliat Acts as a Potent Inhibitor of TNF-alpha Effect by Inhibiting NF-kappaB-Regulated Genes in Human Breast Cancer Cells. Anthocyanins 16-27 tumor necrosis factor Homo sapiens 101-110 32455624-0 2020 Pretreatment of Anthocyanin from the Fruit of Vitis coignetiae Pulliat Acts as a Potent Inhibitor of TNF-alpha Effect by Inhibiting NF-kappaB-Regulated Genes in Human Breast Cancer Cells. Anthocyanins 16-27 nuclear factor kappa B subunit 1 Homo sapiens 132-141 32455624-5 2020 We investigated the effects of anthocyanins extracted from the fruits of Vitis coignetiae Pulliat (AIM, anthocyanins isolated from Meoru (AIM)) on TNF-alpha-induced NF-kappaB activities in MCF-7 human breast cancer cells and the molecules involved in AIM-induced anti-cancer effects, especially on cancer metastasis. Anthocyanins 31-43 tumor necrosis factor Homo sapiens 147-156 32455624-5 2020 We investigated the effects of anthocyanins extracted from the fruits of Vitis coignetiae Pulliat (AIM, anthocyanins isolated from Meoru (AIM)) on TNF-alpha-induced NF-kappaB activities in MCF-7 human breast cancer cells and the molecules involved in AIM-induced anti-cancer effects, especially on cancer metastasis. Anthocyanins 31-43 nuclear factor kappa B subunit 1 Homo sapiens 165-174 32455624-5 2020 We investigated the effects of anthocyanins extracted from the fruits of Vitis coignetiae Pulliat (AIM, anthocyanins isolated from Meoru (AIM)) on TNF-alpha-induced NF-kappaB activities in MCF-7 human breast cancer cells and the molecules involved in AIM-induced anti-cancer effects, especially on cancer metastasis. Anthocyanins 104-116 tumor necrosis factor Homo sapiens 147-156 32455624-5 2020 We investigated the effects of anthocyanins extracted from the fruits of Vitis coignetiae Pulliat (AIM, anthocyanins isolated from Meoru (AIM)) on TNF-alpha-induced NF-kappaB activities in MCF-7 human breast cancer cells and the molecules involved in AIM-induced anti-cancer effects, especially on cancer metastasis. Anthocyanins 104-116 nuclear factor kappa B subunit 1 Homo sapiens 165-174 32455624-9 2020 In conclusion, this study demonstrates that the anthocyanins isolated from the fruits of Vitis coignetiae Pulliat acts as an inhibitor of TNF-alpha induced NF-kappaB activation, and subsequent downstream molecules involved in cancer proliferation, invasion, adhesion, angiogenesis, and thus have anti-metastatic activities in MCF-7 breast cancer cells. Anthocyanins 48-60 tumor necrosis factor Homo sapiens 138-147 32455624-9 2020 In conclusion, this study demonstrates that the anthocyanins isolated from the fruits of Vitis coignetiae Pulliat acts as an inhibitor of TNF-alpha induced NF-kappaB activation, and subsequent downstream molecules involved in cancer proliferation, invasion, adhesion, angiogenesis, and thus have anti-metastatic activities in MCF-7 breast cancer cells. Anthocyanins 48-60 nuclear factor kappa B subunit 1 Homo sapiens 156-165 32438746-0 2020 Black Bean Anthocyanin-Rich Extract from Supercritical and Pressurized Extraction Increased In Vitro Antidiabetic Potential, While Having Similar Storage Stability. Anthocyanins 11-22 brain expressed associated with NEDD4 1 Homo sapiens 6-10 32438746-1 2020 Black bean is a source of anthocyanins and other phenolic compounds that are associated with health benefits. Anthocyanins 26-38 brain expressed associated with NEDD4 1 Homo sapiens 6-10 32438746-2 2020 This work aimed to optimize the extraction and determine the stability and biological potential of black bean anthocyanin-rich extracts recovered by supercritical fluid extraction (SFE) and pressurized liquid extraction (PLE). Anthocyanins 110-121 brain expressed associated with NEDD4 1 Homo sapiens 105-109 32007662-0 2020 Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways. Anthocyanins 39-51 interleukin 6 Mus musculus 124-128 32357153-1 2020 Dihydroflavonol 4-reductase (DFR), a key enzyme involved in the biosynthesis of anthocyanins, has been cloned from various species. Anthocyanins 80-92 dihydroflavonol 4-reductase Arabidopsis thaliana 29-32 32065029-6 2020 SAG13 is also required for normal seed germination, seedling growth, and anthocyanin accumulation. Anthocyanins 73-84 senescence-associated gene 13 Arabidopsis thaliana 0-5 31811679-7 2020 Consistent with the role of SPX proteins in the suppression of the PHR1 transcriptional activator, the master regulator for phosphate starvation responses, nitrate-dependent enhancement of phosphate starvation responses, such as accumulation of anthocyanin and promotion of root hair growth and phosphate uptake, was less evident in the nigt1.1-nigt1.4 quadruple mutant. Anthocyanins 245-256 spexin hormone Homo sapiens 28-31 32357153-11 2020 The discovery of the Arg-type DFR provides new insights into the anthocyanin biosynthesis pathway in ferns. Anthocyanins 65-76 dihydroflavonol 4-reductase Arabidopsis thaliana 30-33 32312227-0 2020 MYB transcription factor PdMYB118 directly interacts with bHLH transcription factor PdTT8 to regulate wound-induced anthocyanin biosynthesis in poplar. Anthocyanins 116-127 MYB proto-oncogene, transcription factor Homo sapiens 0-3 32179241-9 2020 Moreover, 320 mg/day anthocyanin supplementation reduced serum IL-6 (-40%), TNF-alpha (-21%), MDA (-20%) and urine 8-iso-PGF2alpha (-37%) and 8-OHdG (-36%) than 80 mg/day and 40 mg/day anthocyanins, P value < 0.05. Anthocyanins 21-32 tumor necrosis factor Homo sapiens 76-85 32179241-10 2020 Anthocyanin supplementation has dose-response relationships with decreased inflammatory cytokines IL-6, TNF-alpha and oxidative stress biomarkers 8-iso-PGF2alpha, 8-OHdG and MDA (P for trend, <0.05). Anthocyanins 0-11 interleukin 6 Homo sapiens 98-102 32179241-10 2020 Anthocyanin supplementation has dose-response relationships with decreased inflammatory cytokines IL-6, TNF-alpha and oxidative stress biomarkers 8-iso-PGF2alpha, 8-OHdG and MDA (P for trend, <0.05). Anthocyanins 0-11 tumor necrosis factor Homo sapiens 104-113 32179241-11 2020 Furthermore, a strong positive correlation was observed between the changes in the urine 8-iso-PGF2alpha , 8-OHdG levels and serum IL-6 levels in subjects from anthocyanin groups after 12 weeks of treatment. Anthocyanins 160-171 interleukin 6 Homo sapiens 131-135 32340142-6 2020 These properties could be attributed to the polyphenols, mainly anthocyanins and flavonols, detected by RP-HPLC-DAD-ESI-MSn. Anthocyanins 64-76 moesin Homo sapiens 120-123 32179241-7 2020 A slight reduction in serum IL-6, TNF-alpha, and urine 8-iso-PGF2alpha from the baseline was observed at 12 weeks in the group receiving 40 mg/day anthocyanins. Anthocyanins 147-159 interleukin 6 Homo sapiens 28-32 32179241-7 2020 A slight reduction in serum IL-6, TNF-alpha, and urine 8-iso-PGF2alpha from the baseline was observed at 12 weeks in the group receiving 40 mg/day anthocyanins. Anthocyanins 147-159 tumor necrosis factor Homo sapiens 34-43 32179241-8 2020 Anthocyanins (80 mg/day) significantly reduced serum IL-6 (-20%), TNF-alpha (-11%) and urine 8-iso-PGF2alpha (-27%) versus baseline (P < 0.05). Anthocyanins 0-12 interleukin 6 Homo sapiens 53-57 32179241-8 2020 Anthocyanins (80 mg/day) significantly reduced serum IL-6 (-20%), TNF-alpha (-11%) and urine 8-iso-PGF2alpha (-27%) versus baseline (P < 0.05). Anthocyanins 0-12 tumor necrosis factor Homo sapiens 66-75 32179241-9 2020 Moreover, 320 mg/day anthocyanin supplementation reduced serum IL-6 (-40%), TNF-alpha (-21%), MDA (-20%) and urine 8-iso-PGF2alpha (-37%) and 8-OHdG (-36%) than 80 mg/day and 40 mg/day anthocyanins, P value < 0.05. Anthocyanins 21-32 interleukin 6 Homo sapiens 63-67 32312227-3 2020 RESULTS: In this work, we report that expression of anthocyanin biosynthesis genes (ABGs) were activated by PdMYB118, a MYB TF encoding gene from Populus deltoids, and the activation of PdMYB118 was significantly enhanced by PdTT8, a bHLH protein, through its direct interaction with PdMYB118. Anthocyanins 52-63 MYB proto-oncogene, transcription factor Homo sapiens 110-113 32066082-4 2020 Grape cells dual cultured with fungal strains XH-2, R2-21 and B2-17 showed significant differences of their anthocyanin concentrations were subjected to further analysis of their anthocyanidin compositions. Anthocyanins 108-119 immunoglobulin kappa variable 5-2 Homo sapiens 62-67 32290535-4 2020 Also, recent studies in either experimental animal models or in humans, have shown encouraging results for insulin-sensitizing nutritional supplements derived from MedDiet food sources in the modulation of pathognomonic traits of certain IR-related conditions, including polyunsaturated fatty acids from olive oil and seeds, anthocyanins from purple vegetables and fruits, resveratrol from grapes, and the EVOO-derived, oleacein. Anthocyanins 325-337 insulin Homo sapiens 107-114 31796358-3 2020 The anthocyanin cyanidin-3-O-glucoside (C3G) is phytochemical rich in plants and fruits and has been shown to have remarkable anti-oxidant activity, making it an ideal nutrient for nutritional intervention. Anthocyanins 4-38 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 40-43 32061902-0 2020 Anthocyanins reduce inflammation and improve glucose and lipid metabolism associated with inhibiting nuclear factor-kappaB activation and increasing PPAR-gamma gene expression in metabolic syndrome subjects. Anthocyanins 0-12 peroxisome proliferator activated receptor gamma Homo sapiens 149-159 32061902-3 2020 The effects of berry-rich anthocyanin supplements (320 mg/day) for four weeks were examined on features of metabolic syndrome components and the expression of PPAR-gamma, Nrf2, and NF-kappaB dependent genes in MetS and healthy subjects. Anthocyanins 26-37 peroxisome proliferator activated receptor gamma Homo sapiens 159-169 32061902-8 2020 Anthocyanin supplementation also down-regulated the expression of NF-kappaB dependent genes including TNF-alpha (-28% and -15%), IL-6 (-16.1% and-13.6%), IL-1A (-21.5% and-12.9%), PCAM-1 (-15% and-17.5%), and COX-2(-26% and-27%) in both MetS and Control group respectively (P-value < 0.05). Anthocyanins 0-11 nuclear factor kappa B subunit 1 Homo sapiens 66-75 32061902-8 2020 Anthocyanin supplementation also down-regulated the expression of NF-kappaB dependent genes including TNF-alpha (-28% and -15%), IL-6 (-16.1% and-13.6%), IL-1A (-21.5% and-12.9%), PCAM-1 (-15% and-17.5%), and COX-2(-26% and-27%) in both MetS and Control group respectively (P-value < 0.05). Anthocyanins 0-11 tumor necrosis factor Homo sapiens 102-111 32061902-8 2020 Anthocyanin supplementation also down-regulated the expression of NF-kappaB dependent genes including TNF-alpha (-28% and -15%), IL-6 (-16.1% and-13.6%), IL-1A (-21.5% and-12.9%), PCAM-1 (-15% and-17.5%), and COX-2(-26% and-27%) in both MetS and Control group respectively (P-value < 0.05). Anthocyanins 0-11 interleukin 6 Homo sapiens 129-133 32061902-8 2020 Anthocyanin supplementation also down-regulated the expression of NF-kappaB dependent genes including TNF-alpha (-28% and -15%), IL-6 (-16.1% and-13.6%), IL-1A (-21.5% and-12.9%), PCAM-1 (-15% and-17.5%), and COX-2(-26% and-27%) in both MetS and Control group respectively (P-value < 0.05). Anthocyanins 0-11 interleukin 1 alpha Homo sapiens 154-159 32061902-8 2020 Anthocyanin supplementation also down-regulated the expression of NF-kappaB dependent genes including TNF-alpha (-28% and -15%), IL-6 (-16.1% and-13.6%), IL-1A (-21.5% and-12.9%), PCAM-1 (-15% and-17.5%), and COX-2(-26% and-27%) in both MetS and Control group respectively (P-value < 0.05). Anthocyanins 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 209-214 31952012-7 2020 Taken together this suggests that the anthocyanins which are high in BC have their greatest effect on postprandial hyperglycaemia by inhibiting alpha-glucosidase activity. Anthocyanins 38-50 sucrase-isomaltase Homo sapiens 144-161 31952012-10 2020 However, specific anthocyanins identified in BC which were low in GC were shown to inhibit alpha-glucosidase. Anthocyanins 18-30 sucrase-isomaltase Homo sapiens 91-108 31952012-11 2020 In conclusion the anthocyanins in BC appear to regulate postprandial hyperglycaemia primarily but not solely by inhibiting alpha-glucosidase while other phenolics modulate salivary alpha-amylase, glucose uptake and sugar transporters which together could lower the associated risk of developing type-2 diabetes. Anthocyanins 18-30 sucrase-isomaltase Homo sapiens 123-140 32016380-0 2020 FvbHLH9, functions as a positive regulator of anthocyanin biosynthesis, by forming HY5-bHLH9 transcription complex in strawberry fruits. Anthocyanins 46-57 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 83-86 32016380-2 2020 Light is indispensable for anthocyanin accumulation, and light-inducible MYB and HY5 were considered to promote anthocyanin accumulation in many fruits. Anthocyanins 112-123 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 81-84 32016380-6 2020 Finally, we confirmed that FvbHLH9 promoted anthocyanin accumulation is dependent on HY5-bHLH heterodimer in Arabidopsis. Anthocyanins 44-55 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 85-88 32016380-7 2020 Our findings provide insights into a mechanism involving the synergistic regulation of light-dependent coloration and anthocyanin biosynthesis via HY5-bHLH heterodimer formed by the interaction of FvHY5 with FvbHLH9 in strawberry fruits. Anthocyanins 118-129 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 147-150 32066082-5 2020 Compared to the no-fungus controls, grape cells exposed to fungal strains XH-2 and R2-21 exhibited quantitative promotion of their total anthocyanidin concentrations by 74% and 28%, respectively, whereas treatment with the fungus B2-17 reduced the anthocyanidin content by 19%. Anthocyanins 137-150 immunoglobulin kappa variable 5-2 Homo sapiens 230-235 32066082-5 2020 Compared to the no-fungus controls, grape cells exposed to fungal strains XH-2 and R2-21 exhibited quantitative promotion of their total anthocyanidin concentrations by 74% and 28%, respectively, whereas treatment with the fungus B2-17 reduced the anthocyanidin content by 19%. Anthocyanins 248-261 immunoglobulin kappa variable 5-2 Homo sapiens 230-235 31625612-0 2020 Anthocyanin Fruit encodes an R2R3-MYB transcription factor, SlAN2-like, activating the transcription of SlMYBATV to fine-tune anthocyanin content in tomato fruit. Anthocyanins 0-11 transcription factor MYB75 Solanum lycopersicum 60-65 31756273-4 2020 Expression patterns of the genes ANR, ANS, FLS, LAR, C4H, PAL, CHI, CHS and DFR revealed that the metabolism of anthocyanin is positively regulated by high temperature and/or light levels in summer. Anthocyanins 112-123 protein tyrosine phosphatase receptor type F Homo sapiens 48-51 31952012-0 2020 The anthocyanins in black currants regulate postprandial hyperglycaemia primarily by inhibiting alpha-glucosidase while other phenolics modulate salivary alpha-amylase, glucose uptake and sugar transporters. Anthocyanins 4-16 sucrase-isomaltase Homo sapiens 96-113 31625612-0 2020 Anthocyanin Fruit encodes an R2R3-MYB transcription factor, SlAN2-like, activating the transcription of SlMYBATV to fine-tune anthocyanin content in tomato fruit. Anthocyanins 126-137 transcription factor MYB75 Solanum lycopersicum 60-65 31625612-5 2020 The CRISPR/Cas9-mediated SlAN2-like mutants show a much lower accumulation of anthocyanins associated with the downregulation of multiple anthocyanin-related genes compared to the wild-type tomato, indicating that SlAN2-like is responsible for the Aft phenotype. Anthocyanins 78-90 transcription factor MYB75 Solanum lycopersicum 25-30 31625612-5 2020 The CRISPR/Cas9-mediated SlAN2-like mutants show a much lower accumulation of anthocyanins associated with the downregulation of multiple anthocyanin-related genes compared to the wild-type tomato, indicating that SlAN2-like is responsible for the Aft phenotype. Anthocyanins 78-90 transcription factor MYB75 Solanum lycopersicum 214-219 31625612-5 2020 The CRISPR/Cas9-mediated SlAN2-like mutants show a much lower accumulation of anthocyanins associated with the downregulation of multiple anthocyanin-related genes compared to the wild-type tomato, indicating that SlAN2-like is responsible for the Aft phenotype. Anthocyanins 78-89 transcription factor MYB75 Solanum lycopersicum 25-30 32121223-0 2020 Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in an in vitro Model of Atherosclerosis. Anthocyanins 66-78 selectin E Homo sapiens 32-42 32005403-0 2020 SUMO E3 Ligase SIZ1 stabilizes MYB75 to regulate anthocyanin accumulation under high light conditions in Arabidopsis. Anthocyanins 49-60 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 15-19 32005403-0 2020 SUMO E3 Ligase SIZ1 stabilizes MYB75 to regulate anthocyanin accumulation under high light conditions in Arabidopsis. Anthocyanins 49-60 production of anthocyanin pigment 1 Arabidopsis thaliana 31-36 32005403-2 2020 This paper presents evidence that SUMO E3 ligase SIZ1 positively regulates anthocyanin accumulation. Anthocyanins 75-86 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 49-53 32005403-3 2020 Loss-of-function siz1 mutant seedlings exhibit anthocyanin accumulation-reduced phenotype under high light conditions. Anthocyanins 47-58 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 17-21 32005403-4 2020 Moreover, SIZ1 interacts and sumoylates MYB75/PAP1, a key transcription factor in anthocyanin accumulation. Anthocyanins 82-93 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 10-14 32005403-4 2020 Moreover, SIZ1 interacts and sumoylates MYB75/PAP1, a key transcription factor in anthocyanin accumulation. Anthocyanins 82-93 production of anthocyanin pigment 1 Arabidopsis thaliana 40-45 32005403-4 2020 Moreover, SIZ1 interacts and sumoylates MYB75/PAP1, a key transcription factor in anthocyanin accumulation. Anthocyanins 82-93 phosphatidic acid phosphatase 1 Arabidopsis thaliana 46-50 32005403-6 2020 Anthocyanin accumulation in mutant myb75-c can not be rescued by expressing MYB75K246R, but expression of wild-type MYB75WT complements the mutant phenotype. Anthocyanins 0-11 production of anthocyanin pigment 1 Arabidopsis thaliana 35-40 32005403-9 2020 And SIZ1 is involved in the light-induced accumulation of anthocyanins. Anthocyanins 58-70 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 4-8 32121223-0 2020 Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in an in vitro Model of Atherosclerosis. Anthocyanins 66-78 vascular endothelial growth factor A Homo sapiens 47-51 32121223-8 2020 In addition, anthocyanins and their metabolites significantly decreased (p < 0.001) VEGF production. Anthocyanins 13-25 vascular endothelial growth factor A Homo sapiens 84-88 32003387-0 2020 Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia. Anthocyanins 9-21 presenilin 1 Mus musculus 81-86 32106617-0 2020 Antioxidant Blueberry Anthocyanins Induce Vasodilation via PI3K/Akt Signaling Pathway in High-Glucose-Induced Human Umbilical Vein Endothelial Cells. Anthocyanins 22-34 AKT serine/threonine kinase 1 Homo sapiens 64-67 32003387-0 2020 Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia. Anthocyanins 9-21 triggering receptor expressed on myeloid cells 2 Mus musculus 105-110 32003387-0 2020 Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia. Anthocyanins 9-21 TYRO protein tyrosine kinase binding protein Mus musculus 111-117 32103143-1 2020 MBW protein complexes containing MYB, bHLH and WD40 repeat factors are known transcriptional regulators of secondary metabolites production such as proanthocyanidins and anthocyanins, and developmental processes such as trichome formation in many plant species. Anthocyanins 170-182 MYB proto-oncogene, transcription factor Homo sapiens 33-36 32106617-3 2020 Pretreatment with blueberry anthocyanin extract, malvidin, malvidin-3-glucoside, and malvidin-3-galactoside significantly ameliorated high-glucose-induced damage by enhancing endogenous antioxidant superoxide dismutase (SOD) and heme oxygenase-1 (HO-1), lowering reactive oxygen species (ROS) generation and NADPH oxidase isoform 4 (NOX4) expression, and increasing the cell vitalities. Anthocyanins 28-39 heme oxygenase 1 Homo sapiens 229-245 32106617-3 2020 Pretreatment with blueberry anthocyanin extract, malvidin, malvidin-3-glucoside, and malvidin-3-galactoside significantly ameliorated high-glucose-induced damage by enhancing endogenous antioxidant superoxide dismutase (SOD) and heme oxygenase-1 (HO-1), lowering reactive oxygen species (ROS) generation and NADPH oxidase isoform 4 (NOX4) expression, and increasing the cell vitalities. Anthocyanins 28-39 NADPH oxidase 4 Homo sapiens 308-331 32106617-3 2020 Pretreatment with blueberry anthocyanin extract, malvidin, malvidin-3-glucoside, and malvidin-3-galactoside significantly ameliorated high-glucose-induced damage by enhancing endogenous antioxidant superoxide dismutase (SOD) and heme oxygenase-1 (HO-1), lowering reactive oxygen species (ROS) generation and NADPH oxidase isoform 4 (NOX4) expression, and increasing the cell vitalities. Anthocyanins 28-39 NADPH oxidase 4 Homo sapiens 333-337 32098265-5 2020 LPS induced increased relative mRNA expression of splenic (p = 0.0445) and ileal (p = 0.0435) interleukin-1beta (IL-1beta), which was lower in the spleen in carotenoid (p = 0.0114), oligosaccharide (p = 0.0497) and anthocyanin (p = 0.0303)-treated chickens compared to LPS-injected control birds. Anthocyanins 215-226 interleukin 1, beta Gallus gallus 94-111 32098265-5 2020 LPS induced increased relative mRNA expression of splenic (p = 0.0445) and ileal (p = 0.0435) interleukin-1beta (IL-1beta), which was lower in the spleen in carotenoid (p = 0.0114), oligosaccharide (p = 0.0497) and anthocyanin (p = 0.0303)-treated chickens compared to LPS-injected control birds. Anthocyanins 215-226 interleukin 1, beta Gallus gallus 113-121 32093127-7 2020 Upon mechanical wounding or MeJA treatment, expression of AaCOI1 was upregulated after 6 h. When ectopically expressed, driven by the native promoter from Arabidopsis thaliana, AaCOI1 could partially complement the JA sensitivity and defense responses, but fully complemented the fertility, and the JA-induced anthocyanin accumulation in a coi1-16 loss-of-function mutant. Anthocyanins 310-321 RNI-like superfamily protein Arabidopsis thaliana 340-347 31935365-6 2020 Exposure to the LPS increased the production of IL-6 in both HAEC and D-HAEC cell lines (P-value < 0.0001), whereas AC treatment reduced LPS-induced IL-6 production in both cell lines with a more robust impact on D-HAEC (P-value < 0.0001). Anthocyanins 119-121 interleukin 6 Homo sapiens 152-156 32054115-0 2020 Accumulation of Anthocyanins through Overexpression of AtPAP1 in Solanum nigrum Lin. Anthocyanins 16-28 phosphatidic acid phosphatase 1 Arabidopsis thaliana 55-61 32054115-4 2020 Here we employed a genetic approach to study the effects of overexpression of Arabidopsis thaliana production of anthocyanin pigment 1 (AtPAP1) in black nightshade. Anthocyanins 113-124 phosphatidic acid phosphatase 1 Arabidopsis thaliana 136-142 32054115-5 2020 Ectopic expression of AtPAP1 resulted in enhanced accumulation of anthocyanin pigments in vegetative and reproductive tissues of the transgenic plants. Anthocyanins 66-77 phosphatidic acid phosphatase 1 Arabidopsis thaliana 22-28 32054115-9 2020 Our data demonstrate that a major anthocyanin biosynthetic regulator, AtPAP1, can induce accumulation of anthocyanins in the heterologous system of black nightshade through the conserved flavonoid biosynthesis pathway in plants. Anthocyanins 34-45 phosphatidic acid phosphatase 1 Arabidopsis thaliana 70-76 32054115-9 2020 Our data demonstrate that a major anthocyanin biosynthetic regulator, AtPAP1, can induce accumulation of anthocyanins in the heterologous system of black nightshade through the conserved flavonoid biosynthesis pathway in plants. Anthocyanins 105-117 phosphatidic acid phosphatase 1 Arabidopsis thaliana 70-76 31872502-5 2020 In addition, real-time PCR and western blot analyses indicated that AC could protect MIN6 cells against oxidative injury through increasing the translocation of Nrf2 into nuclear, decreasing the phosphorylation level of p38 and up-regulating the protein expression of antioxidant enzyme (SOD1, SOD2 and CAT). Anthocyanins 68-70 nuclear factor, erythroid derived 2, like 2 Mus musculus 161-165 31872502-5 2020 In addition, real-time PCR and western blot analyses indicated that AC could protect MIN6 cells against oxidative injury through increasing the translocation of Nrf2 into nuclear, decreasing the phosphorylation level of p38 and up-regulating the protein expression of antioxidant enzyme (SOD1, SOD2 and CAT). Anthocyanins 68-70 mitogen-activated protein kinase 14 Mus musculus 220-223 31872502-5 2020 In addition, real-time PCR and western blot analyses indicated that AC could protect MIN6 cells against oxidative injury through increasing the translocation of Nrf2 into nuclear, decreasing the phosphorylation level of p38 and up-regulating the protein expression of antioxidant enzyme (SOD1, SOD2 and CAT). Anthocyanins 68-70 superoxide dismutase 1, soluble Mus musculus 288-292 31872502-5 2020 In addition, real-time PCR and western blot analyses indicated that AC could protect MIN6 cells against oxidative injury through increasing the translocation of Nrf2 into nuclear, decreasing the phosphorylation level of p38 and up-regulating the protein expression of antioxidant enzyme (SOD1, SOD2 and CAT). Anthocyanins 68-70 superoxide dismutase 2, mitochondrial Mus musculus 294-298 32030477-2 2020 The Arabidopsis transcription factor Myeloblastosis protein 75 (MYB75, AT1G56650) is known to act as a positive transcriptional regulator of genes required for flavonoid and anthocyanin biosynthesis. Anthocyanins 174-185 production of anthocyanin pigment 1 Arabidopsis thaliana 37-62 32030477-2 2020 The Arabidopsis transcription factor Myeloblastosis protein 75 (MYB75, AT1G56650) is known to act as a positive transcriptional regulator of genes required for flavonoid and anthocyanin biosynthesis. Anthocyanins 174-185 production of anthocyanin pigment 1 Arabidopsis thaliana 64-69 31706031-0 2020 Arabidopsis ECAP is a New Adaptor Protein that Connects JAZ Repressors with TPR2 Co-repressor to Suppress Jasmonate-Responsive Anthocyanin Accumulation. Anthocyanins 127-138 Tetratricopeptide repeat (TPR)-like superfamily protein Arabidopsis thaliana 76-80 31706031-6 2020 We also provide evidence that ECAP is a novel adaptor protein for JAZ6/8 recruitment of the transcriptional co-repressor, TPR2, into a transcriptional repressor complex, to repress the WD-repeat/bHLH/MYB complex, an important transcriptional activator in the JA-dependent anthocyanin biosynthesis pathway. Anthocyanins 272-283 jasmonate-zim-domain protein 6 Arabidopsis thaliana 66-72 31706031-6 2020 We also provide evidence that ECAP is a novel adaptor protein for JAZ6/8 recruitment of the transcriptional co-repressor, TPR2, into a transcriptional repressor complex, to repress the WD-repeat/bHLH/MYB complex, an important transcriptional activator in the JA-dependent anthocyanin biosynthesis pathway. Anthocyanins 272-283 Tetratricopeptide repeat (TPR)-like superfamily protein Arabidopsis thaliana 122-126 31935365-7 2020 While LPS increased inflammasome assembling and caspase-1 activation, AC treatment inhibited caspase-1 activation in D-HAEC (P <= 0.05). Anthocyanins 70-72 caspase 1 Homo sapiens 93-102 31888167-0 2019 Genome- and Transcriptome-Wide Characterization of bZIP Gene Family Identifies Potential Members Involved in Abiotic Stress Response and Anthocyanin Biosynthesis in Radish (Raphanus sativus L.). Anthocyanins 137-148 basic leucine-zipper 8 Arabidopsis thaliana 51-55 31678614-4 2020 Here, we report that whereas Aft encodes a functional allele of an anthocyanin activator named SlAN2-like, atv encodes a non-functional allele of the anthocyanin repressor SlMYBATV. Anthocyanins 67-78 transcription factor MYB75 Solanum lycopersicum 95-100 31678614-5 2020 The expression of SlAN2-like is responsive to light and a functional SlAN2-like can activate both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator and plays a critical role for the activation of anthocyanin biosynthesis. Anthocyanins 98-109 transcription factor MYB75 Solanum lycopersicum 18-23 31678614-5 2020 The expression of SlAN2-like is responsive to light and a functional SlAN2-like can activate both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator and plays a critical role for the activation of anthocyanin biosynthesis. Anthocyanins 98-109 transcription factor MYB75 Solanum lycopersicum 69-74 31678614-5 2020 The expression of SlAN2-like is responsive to light and a functional SlAN2-like can activate both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator and plays a critical role for the activation of anthocyanin biosynthesis. Anthocyanins 98-109 transcription factor MYB75 Solanum lycopersicum 69-74 31678614-5 2020 The expression of SlAN2-like is responsive to light and a functional SlAN2-like can activate both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator and plays a critical role for the activation of anthocyanin biosynthesis. Anthocyanins 259-270 transcription factor MYB75 Solanum lycopersicum 18-23 31678614-5 2020 The expression of SlAN2-like is responsive to light and a functional SlAN2-like can activate both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator and plays a critical role for the activation of anthocyanin biosynthesis. Anthocyanins 259-270 transcription factor MYB75 Solanum lycopersicum 69-74 31678614-5 2020 The expression of SlAN2-like is responsive to light and a functional SlAN2-like can activate both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator and plays a critical role for the activation of anthocyanin biosynthesis. Anthocyanins 259-270 transcription factor MYB75 Solanum lycopersicum 69-74 31678614-7 2020 Indeed, expression of a functional SlAN2-like in a tomato cultivar led to the activation of the entire anthocyanin biosynthesis pathway and high levels of anthocyanin accumulation in both peel and flesh. Anthocyanins 103-114 transcription factor MYB75 Solanum lycopersicum 35-40 31678614-7 2020 Indeed, expression of a functional SlAN2-like in a tomato cultivar led to the activation of the entire anthocyanin biosynthesis pathway and high levels of anthocyanin accumulation in both peel and flesh. Anthocyanins 155-166 transcription factor MYB75 Solanum lycopersicum 35-40 31669599-5 2020 Subgroup analyses showed that administration of higher doses of anthocyanins (>300 mg/day) significantly decreased levels of CRP, IL-6, TNF-alpha, and VCAM-1. Anthocyanins 64-76 C-reactive protein Homo sapiens 125-128 31669599-5 2020 Subgroup analyses showed that administration of higher doses of anthocyanins (>300 mg/day) significantly decreased levels of CRP, IL-6, TNF-alpha, and VCAM-1. Anthocyanins 64-76 interleukin 6 Homo sapiens 130-134 31669599-5 2020 Subgroup analyses showed that administration of higher doses of anthocyanins (>300 mg/day) significantly decreased levels of CRP, IL-6, TNF-alpha, and VCAM-1. Anthocyanins 64-76 tumor necrosis factor Homo sapiens 136-145 31669599-5 2020 Subgroup analyses showed that administration of higher doses of anthocyanins (>300 mg/day) significantly decreased levels of CRP, IL-6, TNF-alpha, and VCAM-1. Anthocyanins 64-76 vascular cell adhesion molecule 1 Homo sapiens 151-157 31657664-2 2020 Cyanidin-3-glucoside (C3G) is one of the widespread anthocyanins in plants, and cyanidin (Cy) is the aglycone of C3G that can be generated in intestine under gut microorganism metabolism. Anthocyanins 52-64 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 0-25 32249264-0 2020 Anthocyanidin Extract from Summer-black-grape Affects the Expression of Ki-67 in Testis, Ovary of D-Galactose-induced Aging Mice. Anthocyanins 0-13 antigen identified by monoclonal antibody Ki 67 Mus musculus 72-77 32249264-1 2020 The aim of this work was to analyze the expression of Ki-67 in ovary, testis of aging mice with anthocyanidin extract from Summer-black-grape. Anthocyanins 96-109 antigen identified by monoclonal antibody Ki 67 Mus musculus 54-59 32249264-4 2020 In the anthocyanidin group, the Ki-67 positive particles in the testis and ovary tissue were significantly decreased. Anthocyanins 7-20 antigen identified by monoclonal antibody Ki 67 Mus musculus 32-37 32249264-5 2020 The anthocyanidin of Summer-black-grape reduces the expression of Ki-67 protein in the testis or ovary of aging mice. Anthocyanins 4-17 antigen identified by monoclonal antibody Ki 67 Mus musculus 66-71 31485933-6 2020 Cyanidin-3-O-glucoside (C3G), a type of anthocyanin, possesses powerful anti-inflammatory activities. Anthocyanins 40-51 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 24-27 31872502-5 2020 In addition, real-time PCR and western blot analyses indicated that AC could protect MIN6 cells against oxidative injury through increasing the translocation of Nrf2 into nuclear, decreasing the phosphorylation level of p38 and up-regulating the protein expression of antioxidant enzyme (SOD1, SOD2 and CAT). Anthocyanins 68-70 catalase Mus musculus 303-306 31250952-5 2020 In addition, an apple RING E3 ubiquitin ligase MYB30-INTERACTING E3 LIGASE 1 (MdMIEL1) was identified to be an MdMYB308L-interacting protein and promoted the ubiquitination degradation of MdMYB308L, thus negatively regulated cold tolerance and anthocyanin accumulation in apple. Anthocyanins 244-255 myb-related protein 306 Malus domestica 47-76 31654642-0 2020 Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders. Anthocyanins 0-12 mitogen-activated protein kinase kinase kinase 11 Mus musculus 68-72 31654642-8 2020 ANT also inhibited MLK3 activation and its downstream JNK and p38 MAPK signaling cascades. Anthocyanins 0-3 mitogen-activated protein kinase kinase kinase 11 Mus musculus 19-23 31654642-8 2020 ANT also inhibited MLK3 activation and its downstream JNK and p38 MAPK signaling cascades. Anthocyanins 0-3 mitogen-activated protein kinase 8 Mus musculus 54-57 31654642-8 2020 ANT also inhibited MLK3 activation and its downstream JNK and p38 MAPK signaling cascades. Anthocyanins 0-3 mitogen-activated protein kinase 14 Mus musculus 62-65 31654642-9 2020 Moreover, the inhibitor of MLK3 could mimic the effects of ANT. Anthocyanins 59-62 mitogen-activated protein kinase kinase kinase 11 Mus musculus 27-31 31654642-12 2020 ANT could inhibit the activation of MLK3 and be a promising agent for the prevention and treatment of PND. Anthocyanins 0-3 mitogen-activated protein kinase kinase kinase 11 Mus musculus 36-40 31927487-2 2020 Ubiquitin E3 ligase COP1 has been proved to be a negative regulator involved in light-regulated plant development process, whereas the function and expression specificity of COP1 in anthocyanin biosynthesis in sweet cherry remains unclear. Anthocyanins 182-193 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 174-178 31927487-3 2020 In the present study, we identified a COP1 in sweet cherry, named PacCOP1, it exhibited apparent different expression patterns in red-colored "Hongdeng" and bi-colored "Satonishiki", with increasing trend largely in "Satonishiki", but decreasing trend in "Hongdeng" after veraison, which was contrary to their variation tendency of anthocyanin content. Anthocyanins 332-343 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 38-42 31746378-0 2020 Blueberry anthocyanin-enriched extract ameliorates transverse aortic constriction-induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice. Anthocyanins 10-21 dimethylarginine dimethylaminohydrolase 1 Mus musculus 121-126 31557372-9 2020 Additionally, jaz4-1 mutant plants have increased anthocyanin accumulation and late flowering compared with Col-0, while JAZ4 Jas lines showed no alteration in anthocyanin production. Anthocyanins 50-61 jasmonate-zim-domain protein 4 Arabidopsis thaliana 14-18 31888492-0 2019 Ectopic expression of citrus UDP-GLUCOSYL TRANSFERASE gene enhances anthocyanin and proanthocyanidins contents and confers high light tolerance in Arabidopsis. Anthocyanins 68-79 UDP-glucosyltransferase 75B1 Arabidopsis thaliana 29-53 31888492-8 2019 CONCLUSION: Our study concluded that the citrus Cs-UGT78D3 gene contributes to proanthocyanidins accumulation in seed coats and confers tolerance to high light stress by accumulating the total anthocyanin and flavonoid contents with better antioxidant potential (due to photoprotective activity of anthocyanin) in the transgenic Arabidopsis. Anthocyanins 193-204 UDP-glucosyl transferase 78D3 Arabidopsis thaliana 51-58 31888492-8 2019 CONCLUSION: Our study concluded that the citrus Cs-UGT78D3 gene contributes to proanthocyanidins accumulation in seed coats and confers tolerance to high light stress by accumulating the total anthocyanin and flavonoid contents with better antioxidant potential (due to photoprotective activity of anthocyanin) in the transgenic Arabidopsis. Anthocyanins 298-309 UDP-glucosyl transferase 78D3 Arabidopsis thaliana 51-58 31888167-1 2019 Basic leucine zipper (bZIP) transcription factors play crucial roles in various abiotic stress responses as well as anthocyanin accumulation. Anthocyanins 116-127 basic leucine-zipper 8 Arabidopsis thaliana 22-26 31888167-8 2019 Furthermore, the promoter sequences of 39 anthocyanin-related genes were found to contain G-box or ACE-box elements that could be recognized by bZIP family members. Anthocyanins 42-53 basic leucine-zipper 8 Arabidopsis thaliana 144-148 31888167-11 2019 These results facilitate further investigation on functional characterization of bZIP genes in response to abiotic stress and anthocyanin biosynthesis in radish. Anthocyanins 126-137 basic leucine-zipper 8 Arabidopsis thaliana 81-85 31781740-2 2019 Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes. Anthocyanins 29-40 glucagon Rattus norvegicus 88-111 31377624-1 2019 Self-assembled nanoparticles using the biopolymers chitosan (CH) and chondroitin sulfate (CS) were developed to improve the biological activity of anthocyanin (ACN). Anthocyanins 160-163 DDB1 and CUL4 associated factor 7 Homo sapiens 147-158 31781740-2 2019 Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes. Anthocyanins 29-40 glucagon Rattus norvegicus 113-118 31815637-14 2019 The observed positive relation between anthocyanins and stilbenes could be attributable to an increased influx of phenylpropanoid intermediaries due to the replenished activity of MYBA1, an effect yet to be demonstrated in other somatic variants. Anthocyanins 39-51 MYBA1 Vitis vinifera 180-185 31743023-5 2019 Therefore, in this present study, anthocyanins isolated from blueberry were used to study the inhibitory activity on PTP1B. Anthocyanins 34-46 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 117-122 31743023-7 2019 Structure activity relationship (SAR) between anthocyanins and PTP1B inhibition was investigated. Anthocyanins 46-58 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 63-68 31743023-8 2019 The enzyme activity inhibition and molecular docking showed that anthocyanins had high selectivity for PTP1B inhibition. Anthocyanins 65-77 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 103-108 31743023-11 2019 Taken together, our study clearly illustrated the SAR between anthocyanins and PTP1B inhibition and the mechanism of Cya-3-Ara in insulin signaling pathway. Anthocyanins 62-74 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 79-84 31780719-8 2019 BBX1 enhanced the activation of MYB10 and MdbHLH3 on the promoter of the anthocyanin biosynthetic gene DFR. Anthocyanins 73-84 transcription factor MYB113-like Malus domestica 32-37 31805676-6 2019 These results indicate that, under low sunlight intensity, anthocyanin synthesis in apple peel was limited by the supply of the substrate cyanidin, which was regulated by the DFR activity. Anthocyanins 59-70 bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase Malus domestica 175-178 31805676-7 2019 Nevertheless, after exposure to high sunlight intensity, the anthocyanin produced in the apple peel was dependent on UFGT activity. Anthocyanins 61-72 anthocyanidin 3-O-glucosyltransferase 2-like Malus domestica 117-121 31774233-0 2019 Anthocyanidin attenuates myocardial ischemia induced injury via inhibition of ROS-JNK-Bcl-2 pathway: New mechanism of anthocyanidin action. Anthocyanins 0-13 mitogen-activated protein kinase 8 Mus musculus 82-85 31774233-0 2019 Anthocyanidin attenuates myocardial ischemia induced injury via inhibition of ROS-JNK-Bcl-2 pathway: New mechanism of anthocyanidin action. Anthocyanins 0-13 B cell leukemia/lymphoma 2 Mus musculus 86-91 31774233-0 2019 Anthocyanidin attenuates myocardial ischemia induced injury via inhibition of ROS-JNK-Bcl-2 pathway: New mechanism of anthocyanidin action. Anthocyanins 118-131 mitogen-activated protein kinase 8 Mus musculus 82-85 31774233-0 2019 Anthocyanidin attenuates myocardial ischemia induced injury via inhibition of ROS-JNK-Bcl-2 pathway: New mechanism of anthocyanidin action. Anthocyanins 118-131 B cell leukemia/lymphoma 2 Mus musculus 86-91 31774233-9 2019 Mechanistically, pretreatment with anthocyanidin significantly subdued the activation of JNK (to p-JNK) and elevated Bcl-2 levels. Anthocyanins 35-48 mitogen-activated protein kinase 8 Mus musculus 89-92 31774233-9 2019 Mechanistically, pretreatment with anthocyanidin significantly subdued the activation of JNK (to p-JNK) and elevated Bcl-2 levels. Anthocyanins 35-48 mitogen-activated protein kinase 8 Mus musculus 97-102 31774233-9 2019 Mechanistically, pretreatment with anthocyanidin significantly subdued the activation of JNK (to p-JNK) and elevated Bcl-2 levels. Anthocyanins 35-48 B cell leukemia/lymphoma 2 Mus musculus 117-122 31774233-11 2019 We have provided the experimental evidence for inhibition of ROS/p-JNK/Bcl-2 pathway being the underlying mechanism of action of anthocyanidin. Anthocyanins 129-142 mitogen-activated protein kinase 8 Mus musculus 65-70 31774233-11 2019 We have provided the experimental evidence for inhibition of ROS/p-JNK/Bcl-2 pathway being the underlying mechanism of action of anthocyanidin. Anthocyanins 129-142 B cell leukemia/lymphoma 2 Mus musculus 71-76 31780719-8 2019 BBX1 enhanced the activation of MYB10 and MdbHLH3 on the promoter of the anthocyanin biosynthetic gene DFR. Anthocyanins 73-84 bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase Malus domestica 103-106 31827486-0 2019 Ectopic Expression of PAP1 Leads to Anthocyanin Accumulation and Novel Floral Color in Genetically Engineered Goldenrod (Solidago canadensis L.). Anthocyanins 36-47 production of anthocyanin pigment 1 Arabidopsis thaliana 22-26 31771252-0 2019 The Effects of Anthocyanins and Their Microbial Metabolites on the Expression and Enzyme Activities of Paraoxonase 1, an Important Marker of HDL Function. Anthocyanins 15-27 paraoxonase 1 Homo sapiens 103-116 31775396-0 2019 An Anthocyanin-Rich Mixed-Berry Intervention May Improve Insulin Sensitivity in a Randomized Trial of Overweight and Obese Adults. Anthocyanins 3-14 insulin Homo sapiens 57-64 31771252-4 2019 Reported data from randomized controlled trials have shown that anthocyanin consumption increased PON1 activity. Anthocyanins 64-75 paraoxonase 1 Homo sapiens 98-102 31771252-5 2019 However, the underlying molecular mechanisms by which anthocyanins increase PON1 activity are not understood. Anthocyanins 54-66 paraoxonase 1 Homo sapiens 76-80 31771252-6 2019 Therefore, the aim of this research was to investigate the ability of anthocyanins and their metabolites to increase PON1 gene expression and/or enzyme activities as potential mechanisms. Anthocyanins 70-82 paraoxonase 1 Homo sapiens 117-121 31338101-0 2019 Chalcone Isomerase a Key Enzyme for Anthocyanin Biosynthesis in Ophiorrhiza japonica. Anthocyanins 36-47 Chalcone-flavanone isomerase family protein Arabidopsis thaliana 0-18 31752300-0 2019 Overexpression of Maize ZmC1 and ZmR Transcription Factors in Wheat Regulates Anthocyanin Biosynthesis in a Tissue-Specific Manner. Anthocyanins 78-89 anthocyanin regulatory C1 protein Zea mays 24-28 31752300-1 2019 Maize ZmC1 and ZmR transcription factors belong to the MYB-type and bHLH families, respectively, and control anthocyanin biosynthesis. Anthocyanins 109-120 anthocyanin regulatory C1 protein Zea mays 6-10 31752300-2 2019 In this study, Agrobacterium-mediated transformation was used to generate transgenic wheat plants that overexpress ZmC1 and ZmR or both, with the objective of developing anthocyanin-enriched wheat germplasm. Anthocyanins 170-181 anthocyanin regulatory C1 protein Zea mays 115-119 31752300-9 2019 Similarly, quantitative analysis for anthocyanin amounts based on HPLC-MS also confirmed that the transgenic wheat plants with combined overexpression of ZmC1 and ZmR accumulated the highest quantity of pigment products. Anthocyanins 37-48 anthocyanin regulatory C1 protein Zea mays 154-158 31260997-4 2019 HLPC-DAD-ESI-MSn allowed the evaluation of the quantitative and qualitative changes of the main PCs (anthocyanins, flavonols and hydroxycinnamic acid derivatives (HCAD)) present in the grapes during the processing. Anthocyanins 101-113 moesin Homo sapiens 13-16 31415860-5 2019 In addition, the salt-stress caused due to treatment with 25 mM of NaCl resulted in the highest anthocyanin (51.43 mug/mL), 2,2"-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (89.31%), and 2,2-diphenyl-1-picrylhydrazyl (63.28%) radical-scavenging activity. Anthocyanins 96-107 thrombopoietin Mus musculus 119-121 31344284-8 2019 These results indicated that MLNC3.2 and MLNC4.6 function as eTMs for miR156a and prevent cleavage of SPL2-like and SPL33 by miR156a during light-induced anthocyanin biosynthesis. Anthocyanins 154-165 MIR156A Malus domestica 125-132 31653006-8 2019 Moreover, chromatography data showed that PS and PTS possessed 17 identical anthocyanins as a negative regulator of ERK. Anthocyanins 76-88 mitogen-activated protein kinase 1 Mus musculus 116-119 31653006-9 2019 These findings suggested that anthocyanins from PS and PTS inhibited melanogenesis in vitro and in vivo by activating the ERK signaling pathway. Anthocyanins 30-42 mitogen-activated protein kinase 1 Mus musculus 122-125 31550160-3 2019 Anthocyanins are the main flavonoids responsible for Yan73 berry flesh color, and the coloration is coordinately regulated by the VvMYBA1 transcriptional activator and VvMYBC2-L1 transcriptional repressor. Anthocyanins 0-12 MYBA1 Vitis vinifera 130-137 31577300-0 2019 Anthocyanins from black peanut skin protect against UV-B induced keratinocyte cell and skin oxidative damage through activating Nrf 2 signaling. Anthocyanins 0-12 NFE2 like bZIP transcription factor 2 Homo sapiens 128-133 31577300-4 2019 Nuclear-factor-E2-related factor 2 (Nrf 2) was activated by anthocyanins through Nrf 2 protein stabilization and nuclear translocation, along with the expressions of antioxidant responsive element (ARE)- related genes (HO1, GCLC and NOQ1). Anthocyanins 60-72 NFE2 like bZIP transcription factor 2 Homo sapiens 36-41 31577300-4 2019 Nuclear-factor-E2-related factor 2 (Nrf 2) was activated by anthocyanins through Nrf 2 protein stabilization and nuclear translocation, along with the expressions of antioxidant responsive element (ARE)- related genes (HO1, GCLC and NOQ1). Anthocyanins 60-72 NFE2 like bZIP transcription factor 2 Homo sapiens 81-86 31577300-5 2019 Nrf 2 knockdown in HaCaT cells by targeted-shRNA plasmid markedly abolished the protective activity of anthocyanins against UV-B irradiation. Anthocyanins 103-115 NFE2 like bZIP transcription factor 2 Homo sapiens 0-5 31623091-0 2019 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Anthocyanins 76-87 myb-related protein 3R-1-like Nicotiana tabacum 48-51 31623091-1 2019 Overexpression of R2R3-MYB transcriptor can induce up-expression of anthocyanin biosynthesis structural genes, and improve the anthocyanin content in plant tissues, but it is not clear whether the MYB transcription factor overexpression does effect on other genes transcript and chemical compounds accumulation. Anthocyanins 68-79 myb-related protein 3R-1-like Nicotiana tabacum 23-26 31623091-1 2019 Overexpression of R2R3-MYB transcriptor can induce up-expression of anthocyanin biosynthesis structural genes, and improve the anthocyanin content in plant tissues, but it is not clear whether the MYB transcription factor overexpression does effect on other genes transcript and chemical compounds accumulation. Anthocyanins 127-138 myb-related protein 3R-1-like Nicotiana tabacum 23-26 31623091-9 2019 The MYB transcription factor CPC, negative to anthocyanin biosynthesis, also induced up-expression in transgenic lines, which implied that a negative regulation mechanism existed in the anthocyanin biosynthesis pathway. Anthocyanins 46-57 myb-related protein 3R-1-like Nicotiana tabacum 4-7 31623091-9 2019 The MYB transcription factor CPC, negative to anthocyanin biosynthesis, also induced up-expression in transgenic lines, which implied that a negative regulation mechanism existed in the anthocyanin biosynthesis pathway. Anthocyanins 186-197 myb-related protein 3R-1-like Nicotiana tabacum 4-7 31623091-12 2019 This research will give more information about the function of MYB transcription factors on the anthocyanin biosynthesis and other chemical compounds and be of benefit to obtaining new plant cultivars with high anthocyanin content by biotechnology. Anthocyanins 96-107 myb-related protein 3R-1-like Nicotiana tabacum 63-66 31623091-12 2019 This research will give more information about the function of MYB transcription factors on the anthocyanin biosynthesis and other chemical compounds and be of benefit to obtaining new plant cultivars with high anthocyanin content by biotechnology. Anthocyanins 211-222 myb-related protein 3R-1-like Nicotiana tabacum 63-66 31615010-7 2019 Polymerized anthocyanin (PA) downregulated the expression of androgen signaling-related proteins such as 5AR2, AR, and PSA in LNCaP cell lines. Anthocyanins 12-23 androgen receptor Homo sapiens 106-108 31615010-7 2019 Polymerized anthocyanin (PA) downregulated the expression of androgen signaling-related proteins such as 5AR2, AR, and PSA in LNCaP cell lines. Anthocyanins 12-23 kallikrein related peptidase 3 Homo sapiens 119-122 31601032-0 2019 GLABRA2, A Common Regulator for Epidermal Cell Fate Determination and Anthocyanin Biosynthesis in Arabidopsis. Anthocyanins 70-81 HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing protein Arabidopsis thaliana 0-7 31601032-9 2019 In particular, more regulators of GL2 have been identified, and GL2 has been shown to be involved in the regulation of anthocyanin biosynthesis. Anthocyanins 119-130 HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing protein Arabidopsis thaliana 64-67 31601032-10 2019 This review focuses on the research progress on the regulation of GL2 expression, and the roles of GL2 in the regulation of epidermal cell fate determination and anthocyanin biosynthesis in Arabidopsis. Anthocyanins 162-173 HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing protein Arabidopsis thaliana 99-102 31421240-4 2019 Dietary anthocyanin significantly increased respiratory burst activity, phagocytic activity, phagocytic index, lysozyme activity, myeloperoxidase activity, serum total superoxide dismutase (T.SOD) activity, and serum catalase (CAT) activity (p < 0.05). Anthocyanins 8-19 superoxide dismutase [Mn], mitochondrial Oreochromis niloticus 192-195 31421240-4 2019 Dietary anthocyanin significantly increased respiratory burst activity, phagocytic activity, phagocytic index, lysozyme activity, myeloperoxidase activity, serum total superoxide dismutase (T.SOD) activity, and serum catalase (CAT) activity (p < 0.05). Anthocyanins 8-19 catalase Oreochromis niloticus 217-225 31421240-4 2019 Dietary anthocyanin significantly increased respiratory burst activity, phagocytic activity, phagocytic index, lysozyme activity, myeloperoxidase activity, serum total superoxide dismutase (T.SOD) activity, and serum catalase (CAT) activity (p < 0.05). Anthocyanins 8-19 catalase Oreochromis niloticus 227-230 31150089-7 2019 Increased anthocyanin accumulation by 12OH-JA-Ile was additionally observed in tomato and sorghum, and was disrupted by the COI1 defect in tomato jai1 mutant. Anthocyanins 10-21 coronatine-insensitive 1 Solanum lycopersicum 124-128 30375302-0 2019 Up-regulation of miR-24-1-5p is involved in the chemoprevention of colorectal cancer by black raspberry anthocyanins. Anthocyanins 104-116 microRNA 24-1 Homo sapiens 17-25 30375302-3 2019 In this study, microRNA-array differential analysis revealed strongly enhanced expression of miR-24-1-5p in the colon tissue of azoxymethane/dextran sulphate sodium-induced mice that were fed with black raspberry anthocyanins for 9 weeks. Anthocyanins 213-225 microRNA 24-1 Mus musculus 93-101 31213511-5 2019 DcMYB7 could activate the expression of its DcbHLH3 partner, a homolog of the anthocyanin-related apple (Malus x domestica) bHLH3, and structural genes in the anthocyanin biosynthetic pathway. Anthocyanins 78-89 basic helix-loop-helix protein A Malus domestica 46-51 31330482-6 2019 AC supplementation mitigated all these events and increased GLP-2 levels, the intestinal hormone that upregulates TJ protein expression. Anthocyanins 0-2 glucagon-like peptide 2 receptor Mus musculus 60-65 31330482-9 2019 AC supplementation restored microbiota composition and MUC2 levels and distribution in HFD-fed mice. Anthocyanins 0-2 mucin 2 Mus musculus 55-59 31000056-2 2019 A mixed enzymatic treatment containing beta-glucuronidase (100 U mL-1) and sulfatase (2.5 U mL-1) for 5 min (37 C; pH 6) was optimal condition for deconjugation of anthocyanidins and anthocyanins in urine and plasma samples. Anthocyanins 165-179 arylsulfatase family member H Homo sapiens 39-84 31000056-2 2019 A mixed enzymatic treatment containing beta-glucuronidase (100 U mL-1) and sulfatase (2.5 U mL-1) for 5 min (37 C; pH 6) was optimal condition for deconjugation of anthocyanidins and anthocyanins in urine and plasma samples. Anthocyanins 184-196 arylsulfatase family member H Homo sapiens 39-84 31438590-7 2019 Anthocyanin treatment failed to reverse the effects of the high fat diet on body weight and glucose tolerance, but significantly reduced the leptin and IL-6 levels. Anthocyanins 0-11 leptin Mus musculus 141-147 31438590-7 2019 Anthocyanin treatment failed to reverse the effects of the high fat diet on body weight and glucose tolerance, but significantly reduced the leptin and IL-6 levels. Anthocyanins 0-11 interleukin 6 Mus musculus 152-156 31387207-6 2019 Expressions of anthocyanin biosynthesis genes including chalcone flavanone isomerase, chalcone synthase, flavanone 3-hydroxylase, dihydroflavonol 4-reductase, UFGT (UGT78D2), and anthocyanidin synthase were similar to that of PtrMYB119. Anthocyanins 15-26 UDP-glucosyl transferase 78D2 Arabidopsis thaliana 165-172 31229104-0 2019 Protective effects of bovine serum albumin on blueberry anthocyanins under illumination conditions and their mechanism analysis. Anthocyanins 56-68 albumin Homo sapiens 29-42 31229104-1 2019 This study investigates the effects of bovine serum albumin (BSA) on blueberry anthocyanins and their interaction. Anthocyanins 79-91 albumin Homo sapiens 46-59 31021017-0 2019 R2R3-MYB transcription factor MYB6 promotes anthocyanin and proanthocyanidin biosynthesis but inhibits secondary cell wall formation in Populus tomentosa. Anthocyanins 44-55 myb domain protein 6 Arabidopsis thaliana 30-34 31021017-5 2019 Overexpression of MYB6 in transgenic poplar upregulated flavonoid biosynthetic gene expression, resulting in significantly increased accumulation of anthocyanin and proanthocyanidins. Anthocyanins 149-160 myb domain protein 6 Arabidopsis thaliana 18-22 31649709-4 2019 To determine the mechanisms underlying this, "Royal Gala" cultivar apples over-expressing the anthocyanin-related transcription factor (TF) MYB10 (35S:MYB10), which produces fruit with highly pigmented flesh, were compared with standard "Royal Gala" Wild Type (WT) grown under the same conditions. Anthocyanins 94-105 transcription factor MYB113-like Malus domestica 140-145 31649709-6 2019 We assessed concentrations of potential substrates for IBDF and a comparison of metabolites in these apples showed that anthocyanins, chlorogenic acid, pro-cyanidins, flavon-3-ols, and quercetin were all higher in the MYB10 lines. Anthocyanins 120-132 transcription factor MYB113-like Malus domestica 218-223 31649700-0 2019 Cucumber CsTRY Negatively Regulates Anthocyanin Biosynthesis and Trichome Formation When Expressed in Tobacco. Anthocyanins 36-47 transcription factor TRY Cucumis sativus 9-14 31649700-5 2019 In addition, CsTRY could interact with the AN1 homologous gene CsAN1 (Csa7G044190) in cucumber, which further confirmed that CsTRY not only regulates the development of fruit spines, but also functions in the synthesis of flavonoids, acting as the repressor of anthocyanin synthesis. Anthocyanins 261-272 transcription factor TRY Cucumis sativus 13-18 31649700-5 2019 In addition, CsTRY could interact with the AN1 homologous gene CsAN1 (Csa7G044190) in cucumber, which further confirmed that CsTRY not only regulates the development of fruit spines, but also functions in the synthesis of flavonoids, acting as the repressor of anthocyanin synthesis. Anthocyanins 261-272 transcription factor TRY Cucumis sativus 125-130 31590249-0 2019 Anthocyanins Protect Hepatocytes against CCl4-Induced Acute Liver Injury in Rats by Inhibiting Pro-inflammatory mediators, Polyamine Catabolism, Lipocalin-2, and Excessive Proliferation of Kupffer Cells. Anthocyanins 0-12 C-C motif chemokine ligand 4 Rattus norvegicus 41-45 31590249-0 2019 Anthocyanins Protect Hepatocytes against CCl4-Induced Acute Liver Injury in Rats by Inhibiting Pro-inflammatory mediators, Polyamine Catabolism, Lipocalin-2, and Excessive Proliferation of Kupffer Cells. Anthocyanins 0-12 lipocalin 2 Rattus norvegicus 145-156 31590249-1 2019 : This study examined the hepatoprotective and anti-inflammatory effects of anthocyanins from Vaccinim myrtillus (bilberry) fruit extract on the acute liver failure caused by carbon tetrachloride-CCl4 (3 mL/kg, i.p.). Anthocyanins 76-88 C-C motif chemokine ligand 4 Rattus norvegicus 196-200 31590249-2 2019 The preventive treatment of the bilberry extract (200 mg anthocyanins/kg, orally, 7 days) prior to the exposure to the CCl4 resulted in an evident decrease in markers of liver damage (glutamate dehydrogenase, sorbitol dehydrogenase, malate dehydrogenase), and reduced pro-oxidative (conjugated dienes, lipid hydroperoxide, thiobarbituric acid reactive substances, advanced oxidation protein products, NADPH oxidase, hydrogen peroxide, oxidized glutathione), and pro-inflammatory markers (tumor necrosis factor-alpha, interleukin-6, nitrite, myeloperoxidase, inducible nitric oxide synthase, cyclooxygenase-2, CD68, lipocalin-2), and also caused a significant decrease in the dissipation of the liver antioxidative defence capacities (reduced glutathione, glutathione S-transferase, and quinone reductase) in comparison to the results detected in the animals treated with CCl4 exclusively. Anthocyanins 57-69 lipocalin 2 Rattus norvegicus 615-626 31590249-2 2019 The preventive treatment of the bilberry extract (200 mg anthocyanins/kg, orally, 7 days) prior to the exposure to the CCl4 resulted in an evident decrease in markers of liver damage (glutamate dehydrogenase, sorbitol dehydrogenase, malate dehydrogenase), and reduced pro-oxidative (conjugated dienes, lipid hydroperoxide, thiobarbituric acid reactive substances, advanced oxidation protein products, NADPH oxidase, hydrogen peroxide, oxidized glutathione), and pro-inflammatory markers (tumor necrosis factor-alpha, interleukin-6, nitrite, myeloperoxidase, inducible nitric oxide synthase, cyclooxygenase-2, CD68, lipocalin-2), and also caused a significant decrease in the dissipation of the liver antioxidative defence capacities (reduced glutathione, glutathione S-transferase, and quinone reductase) in comparison to the results detected in the animals treated with CCl4 exclusively. Anthocyanins 57-69 C-C motif chemokine ligand 4 Rattus norvegicus 871-875 30963689-3 2019 A pear homolog of Arabidopsis thaliana BBX22, PpBBX16, was differentially expressed after fruits were removed from bags and may be involved in anthocyanin biosynthesis. Anthocyanins 143-154 light-regulated zinc finger protein 1 Arabidopsis thaliana 39-44 31352584-9 2019 TsMYC2 was homologous to the bHLH transcription factor regulating anthocyanin biosynthesis and contained three entire functional domains: bHLH-MYC_N, HLH and ACT-like, which were important for exercising regulation of anthocyanin biosynthesis as a bHLH transcription factor. Anthocyanins 66-77 bHLH94 Triticum aestivum 29-54 31145783-0 2019 miR828 and miR858 regulate VvMYB114 to promote anthocyanin and flavonol accumulation in grapes. Anthocyanins 47-58 membrane associated ring-CH-type finger 8 Homo sapiens 0-3 31145783-4 2019 Using sRNA-sequencing, degradome analysis, mRNA-seq and proteomic analysis, we establish that grape lines with high anthocyanin content express two abundant MYB-targeting miRNAs resulting in differential expression of specific MYB proteins. Anthocyanins 116-127 MYB proto-oncogene, transcription factor Homo sapiens 157-160 31145783-4 2019 Using sRNA-sequencing, degradome analysis, mRNA-seq and proteomic analysis, we establish that grape lines with high anthocyanin content express two abundant MYB-targeting miRNAs resulting in differential expression of specific MYB proteins. Anthocyanins 116-127 MYB proto-oncogene, transcription factor Homo sapiens 227-230 31145783-7 2019 MYB suppression and cascade silencing was more robust in grape lines with high anthocyanin content when compared to a flavonol-rich grape line. Anthocyanins 79-90 MYB proto-oncogene, transcription factor Homo sapiens 0-3 31447870-6 2019 Exposure of the inflorescences to 1-MCP pre-treatment followed by 10 mul L-1 ethylene, recovered both inflorescence color and anthocyanin content to control levels. Anthocyanins 126-137 CD46 molecule Homo sapiens 36-39 31132326-10 2019 Among these genes, BoNCED2.1, BoNCED2.2, BoACS11, and BoACO4 showed particularly strong associations with total anthocyanin content of the purple inner leaves. Anthocyanins 112-123 1-aminocyclopropane-1-carboxylate synthase 11 Brassica oleracea 41-48 31128564-0 2019 A functional homologue of Arabidopsis TTG1 from Freesia interacts with bHLH proteins to regulate anthocyanin and proanthocyanidin biosynthesis in both Freesia hybrida and Arabidopsis thaliana. Anthocyanins 97-108 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 38-42 31128564-9 2019 Molecular biological assays validated FhTTG1 might interact with the endogenous bHLH factors to up-regulate genes responsible for anthocyanin and proanthocyanidin biosynthesis and trichome formation, indicating that FhTTG1 might perform exchangeable roles with AtTTG1. Anthocyanins 130-141 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 261-267 31336964-8 2019 Anthocyanin stability was the highest in the regular jam, then the extra jam (15%), and then the light jam, with retention of 22%, 15%, and 12%, respectively. Anthocyanins 0-11 F11 receptor Homo sapiens 53-56 31336964-8 2019 Anthocyanin stability was the highest in the regular jam, then the extra jam (15%), and then the light jam, with retention of 22%, 15%, and 12%, respectively. Anthocyanins 0-11 F11 receptor Homo sapiens 73-76 31336964-8 2019 Anthocyanin stability was the highest in the regular jam, then the extra jam (15%), and then the light jam, with retention of 22%, 15%, and 12%, respectively. Anthocyanins 0-11 F11 receptor Homo sapiens 73-76 31338101-1 2019 Anthocyanins are distributed ubiquitously to terrestrial plants and chalcone isomerase (CHI) catalyzes the stereospecific isomerization of chalcones - a committed step in the anthocyanin biosynthesis pathway. Anthocyanins 0-12 Chalcone-flavanone isomerase family protein Arabidopsis thaliana 68-86 31338101-1 2019 Anthocyanins are distributed ubiquitously to terrestrial plants and chalcone isomerase (CHI) catalyzes the stereospecific isomerization of chalcones - a committed step in the anthocyanin biosynthesis pathway. Anthocyanins 175-186 Chalcone-flavanone isomerase family protein Arabidopsis thaliana 68-86 31569907-6 2019 The optimal conditions in the case of total anthocyanin content (89.3 mg C3GE/g) were an 65% ethanol concentration and 13 min sonication time. Anthocyanins 44-55 cathepsin G Homo sapiens 73-79 31023420-0 2019 ANS-deficient Arabidopsis is sensitive to high light due to impaired anthocyanin photoprotection. Anthocyanins 69-80 leucoanthocyanidin dioxygenase Arabidopsis thaliana 0-3 31023420-2 2019 Anthocyanin synthase (ANS) is the key enzyme in the downstream portion of anthocyanin synthetic pathways. Anthocyanins 74-85 leucoanthocyanidin dioxygenase Arabidopsis thaliana 0-20 31023420-2 2019 Anthocyanin synthase (ANS) is the key enzyme in the downstream portion of anthocyanin synthetic pathways. Anthocyanins 74-85 leucoanthocyanidin dioxygenase Arabidopsis thaliana 22-25 31023420-6 2019 The line with the lowest ANS expression level, ans-1, was also the most sensitive to HL, showing the lowest anthocyanin content, chlorophyll content, Fv/Fm ratio, and Rubisco content and the highest O2 - accumulation and membrane leakage rate, although it also had the highest antioxidant capacity. Anthocyanins 108-119 leucoanthocyanidin dioxygenase Arabidopsis thaliana 47-50 31023420-7 2019 Experimental evidence suggests that ANS mainly regulated the light-attenuating function of anthocyanin in photoprotection under HL. Anthocyanins 91-102 leucoanthocyanidin dioxygenase Arabidopsis thaliana 36-39 31353730-7 2019 These results indicated that AMPK was an important target molecule of VA in the process of alleviating oxidative stress in HUVECs, providing a new potential evidence for vascular protection of anthocyanin in vitro. Anthocyanins 193-204 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 29-33 30912865-10 2019 Phylogenetic analysis suggests that AcMYB123 or AcbHLH42 are closely related to TT2 or TT8, respectively, which determines proanthocyanidin biosynthesis in Arabidopsis, and to anthocyanin regulators in monocots rather than regulators in dicots. Anthocyanins 176-187 Duplicated homeodomain-like superfamily protein Arabidopsis thaliana 80-83 30912865-10 2019 Phylogenetic analysis suggests that AcMYB123 or AcbHLH42 are closely related to TT2 or TT8, respectively, which determines proanthocyanidin biosynthesis in Arabidopsis, and to anthocyanin regulators in monocots rather than regulators in dicots. Anthocyanins 176-187 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 87-90 31079310-8 2019 Molecular complementation of Arabidopsis tt19 demonstrates AcGST1 can complement the anthocyanin-less phenotype of tt19. Anthocyanins 85-96 glutathione S-transferase phi 12 Arabidopsis thaliana 41-45 31079310-8 2019 Molecular complementation of Arabidopsis tt19 demonstrates AcGST1 can complement the anthocyanin-less phenotype of tt19. Anthocyanins 85-96 glutathione S-transferase phi 12 Arabidopsis thaliana 115-119 31079310-11 2019 We further show that AcGST1 protein is localized not only in the ER but also on the tonoplast, indicating AcGST1 (like AtTT19) may functions as a carrier protein to transport anthocyanins to the tonoplast in kiwifruit. Anthocyanins 175-187 glutathione S-transferase phi 12 Arabidopsis thaliana 119-125 31155812-4 2019 Herein, we evaluated the in vitro protective effects of an ACN rich extract against palmitic acid (PA)-induced hypertrophy, inflammation, and insulin resistance in 3T3-L1 adipocytes. Anthocyanins 59-62 insulin Homo sapiens 142-149 31155812-8 2019 ACN extract pretreatment reverts these effects induced by PA and moreover was able to induce insulin pathway with levels higher than insulin control cells, supporting an insulin sensitizer role for ACNs. Anthocyanins 198-202 insulin Homo sapiens 93-100 31155812-9 2019 This study demonstrates a prevention potential of ACNs against obesity comorbidities, due to their protective effects against inflammation/insulin resistance in adipocytes. Anthocyanins 50-54 insulin Homo sapiens 139-146 31155812-10 2019 In addition, these results contribute to the knowledge and strategies on the evaluation of the mechanism of action of ACNs from a food source under basal and insulin resistance conditions related to obesity. Anthocyanins 118-122 insulin Homo sapiens 158-165 31254216-0 2019 Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway. Anthocyanins 0-11 NFE2 like bZIP transcription factor 2 Homo sapiens 115-119 31254216-3 2019 Flavonoids such as anthocyanidins, which are found abundantly in fruits and vegetables, have been shown to activate Nrf2. Anthocyanins 19-33 NFE2 like bZIP transcription factor 2 Homo sapiens 116-120 31254216-4 2019 However, the epigenetic and genetic mechanisms by which anthocyanidins modulate the Nrf2-ARE pathway remain poorly understood in the context of skin cancer. Anthocyanins 56-70 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 31071215-1 2019 A protein complex consisting of a MYB, basic Helix-Loop-Helix, and a WDR protein, the MBW complex, regulates five traits, namely the production of anthocyanidin, proanthocyanidin, and seed-coat mucilage, and the development of trichomes and root hairs. Anthocyanins 147-160 MYB proto-oncogene, transcription factor Homo sapiens 34-37 31215400-5 2019 Overexpression of FtMYB8 in Arabidopsis reduces the accumulation of anthocyanin/proanthocyanidin by specifically inhibiting TT12 expression, which may depend on the interaction between FtMYB8 and TT8. Anthocyanins 68-79 MATE efflux family protein Arabidopsis thaliana 124-128 31215400-5 2019 Overexpression of FtMYB8 in Arabidopsis reduces the accumulation of anthocyanin/proanthocyanidin by specifically inhibiting TT12 expression, which may depend on the interaction between FtMYB8 and TT8. Anthocyanins 68-79 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 196-199 30006757-6 2019 For the 2nd HR donor with the tobacco An2 gene encoding a MYB transcription factor involved in anthocyanin biosynthesis, T-DNA3 had a 35S promoter-driven An2 gene lacking the 3rd exon resulting in anthocyanin accumulation after successful HR. Anthocyanins 197-208 transcription factor MYB114-like Nicotiana tabacum 154-157 31014900-3 2019 This study sought to determine if cyanidin-3-O-glucoside (C3G), a typical anthocyanin with neuroprotective bioactivity, could protect against Cd-induced sex hormone-disorder in Pubertal male mice. Anthocyanins 74-85 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 58-61 31205346-7 2019 Principal component analysis revealed that the variability of data was affected by the race and the alpha-glucosidase and lipase inhibitory activities positively correlated with anthocyanins and antioxidant capacity. Anthocyanins 178-190 lipase Zea mays 122-128 30994936-0 2019 Extraction and Identification of Anthocyanins in Corn Cob and Corn Husk from Cacahuacintle Maize. Anthocyanins 33-45 apocytochrome b Zea mays subsp. mays 54-57 30994936-9 2019 As a result, anthocyanins from corn cob and corn husk were extracted at concentrations of 24.32 and 25.80 mg/gDW, respectively. Anthocyanins 13-25 apocytochrome b Zea mays subsp. mays 36-39 30994936-14 2019 In this work, we established the most efficient extraction method of anthocyanins from corn husk and corn cob, and demonstrated that their anthocyanins profile is comparable to other Peruvian purple corns, which are currently used as natural colorants. Anthocyanins 69-81 apocytochrome b Zea mays subsp. mays 106-109 30725168-0 2019 Repression of anthocyanin biosynthesis by R3-MYB transcription factors in lily (Lilium spp.). Anthocyanins 14-25 myb-related protein 3R-1-like Nicotiana tabacum 45-48 30725168-1 2019 KEY MESSAGE: Lily R3-MYB transcription factors are involved in negative regulation to limit anthocyanin accumulation in lily flowers and leaves and create notable color patterns on ectopically expressed petunia flowers. Anthocyanins 92-103 myb-related protein 3R-1-like Nicotiana tabacum 21-24 30725168-3 2019 The R3-MYB transcription factor is among the main factors repressing anthocyanin biosynthesis. Anthocyanins 69-80 myb-related protein 3R-1-like Nicotiana tabacum 7-10 31035916-9 2019 The AN2 transcript could be detected only in the fruits of L. ruthenicum and increased during fruit development, accompanied by anthocyanin accumulation. Anthocyanins 128-139 transcription factor MYB114-like Nicotiana tabacum 4-7 31035916-12 2019 CONCLUSIONS: Two AN2 alleles, from L. ruthenicum and L. barbarum, were functional MYB transcriptor regulating anthocyanin biosynthesis. Anthocyanins 110-121 transcription factor MYB114-like Nicotiana tabacum 17-20 30362126-5 2019 In addition, lower sly-miR1916 expression could up-regulate the expression of strictosidine synthase (STR-2), UDP-glycosyltransferases (UGTs), late blight resistance protein homolog R1B-16, disease resistance protein RPP13-like, and MYB transcription factor (MYB12), which ultimately resulted in the accumulation of alpha-tomatine and anthocyanins via STR-2, UGT, and MYB12. Anthocyanins 335-347 MIR1916 Solanum lycopersicum 23-30 30362126-5 2019 In addition, lower sly-miR1916 expression could up-regulate the expression of strictosidine synthase (STR-2), UDP-glycosyltransferases (UGTs), late blight resistance protein homolog R1B-16, disease resistance protein RPP13-like, and MYB transcription factor (MYB12), which ultimately resulted in the accumulation of alpha-tomatine and anthocyanins via STR-2, UGT, and MYB12. Anthocyanins 335-347 protein STRICTOSIDINE SYNTHASE-LIKE 13 Solanum lycopersicum 78-100 30362126-5 2019 In addition, lower sly-miR1916 expression could up-regulate the expression of strictosidine synthase (STR-2), UDP-glycosyltransferases (UGTs), late blight resistance protein homolog R1B-16, disease resistance protein RPP13-like, and MYB transcription factor (MYB12), which ultimately resulted in the accumulation of alpha-tomatine and anthocyanins via STR-2, UGT, and MYB12. Anthocyanins 335-347 R2R3MYB transcription factor 14 Solanum lycopersicum 233-257 30362126-5 2019 In addition, lower sly-miR1916 expression could up-regulate the expression of strictosidine synthase (STR-2), UDP-glycosyltransferases (UGTs), late blight resistance protein homolog R1B-16, disease resistance protein RPP13-like, and MYB transcription factor (MYB12), which ultimately resulted in the accumulation of alpha-tomatine and anthocyanins via STR-2, UGT, and MYB12. Anthocyanins 335-347 Myb12 transcription factor Solanum lycopersicum 259-264 30362126-5 2019 In addition, lower sly-miR1916 expression could up-regulate the expression of strictosidine synthase (STR-2), UDP-glycosyltransferases (UGTs), late blight resistance protein homolog R1B-16, disease resistance protein RPP13-like, and MYB transcription factor (MYB12), which ultimately resulted in the accumulation of alpha-tomatine and anthocyanins via STR-2, UGT, and MYB12. Anthocyanins 335-347 Myb12 transcription factor Solanum lycopersicum 368-373 30362126-7 2019 Taken together, the results demonstrated that sly-miR1916 might regulate the expression of STR-2, UGT, and MYB12 in tomato plant, conferring sensitivity to biotic stress via modulating alpha-tomatine and anthocyanins. Anthocyanins 204-216 MIR1916 Solanum lycopersicum 50-57 30362126-7 2019 Taken together, the results demonstrated that sly-miR1916 might regulate the expression of STR-2, UGT, and MYB12 in tomato plant, conferring sensitivity to biotic stress via modulating alpha-tomatine and anthocyanins. Anthocyanins 204-216 Myb12 transcription factor Solanum lycopersicum 107-112 31336964-5 2019 The light jam had the highest phenolic content and anthocyanin content (3.34 g/kg and 985.52 mg/kg). Anthocyanins 51-62 F11 receptor Homo sapiens 10-13 30978605-0 2019 Mechanistic investigation of anthocyanidin derivatives as alpha-glucosidase inhibitors. Anthocyanins 29-42 sucrase-isomaltase Homo sapiens 58-75 30978605-1 2019 Eight anthocyanidin derivatives (1-8) were evaluated as potential inhibitors of the catalysis of alpha-glucosidase. Anthocyanins 6-19 sucrase-isomaltase Homo sapiens 97-114 30914357-2 2019 Cyanidin-3-O-glucoside (C3G) as typical anthocyanin benefits many organs. Anthocyanins 40-51 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 24-27 31000277-5 2019 Fourier transform infrared spectroscopy analysis indicated that the secondary structures of SPI was changed upon conjugation with anthocyanins as there was a decrease in alpha-helix and beta-sheet content. Anthocyanins 130-142 chromogranin A Homo sapiens 92-95 31000277-6 2019 Three-dimensional fluorescence also revealed that the tertiary structure of SPI was less compact after conjugation with anthocyanins as a result of the unfolding of polypeptide chains. Anthocyanins 120-132 chromogranin A Homo sapiens 76-79 31000277-8 2019 However, transepithelial transport of peptides across Caco-2 cell monolayer was decreased in SPI after conjugation with anthocyanins. Anthocyanins 120-132 chromogranin A Homo sapiens 93-96 31000277-9 2019 The results of this study suggest that incorporation of anthocyanins in SPI is a way to reconcile consumer demand for healthier foods with better quality and functionality. Anthocyanins 56-68 chromogranin A Homo sapiens 72-75 31191562-6 2019 Through non-catalytic, so-called ligandin properties, numerous plant GSTs also participate in the binding and transport of small heterocyclic ligands such as flavonoids including anthocyanins, and polyphenols. Anthocyanins 179-191 hematopoietic prostaglandin D synthase Homo sapiens 69-73 30825423-1 2019 This study examined the nephroprotective effects of 15 different anthocyanins from the bilberry extract on the acute kidney injury caused by CCl4. Anthocyanins 65-77 C-C motif chemokine ligand 4 Rattus norvegicus 141-145 30825423-7 2019 The pretreatment of the animals poisoned with CCl4 with the anthocyanins from the bilberry extract led to a noticeable reduction in the pro-oxidative and pro-inflammatory markers with reduced consumption of the antioxidant defence kidney capacity, compared to the animals exposed to CCl4 alone. Anthocyanins 60-72 C-C motif chemokine ligand 4 Rattus norvegicus 46-50 30825423-7 2019 The pretreatment of the animals poisoned with CCl4 with the anthocyanins from the bilberry extract led to a noticeable reduction in the pro-oxidative and pro-inflammatory markers with reduced consumption of the antioxidant defence kidney capacity, compared to the animals exposed to CCl4 alone. Anthocyanins 60-72 C-C motif chemokine ligand 4 Rattus norvegicus 283-287 30825423-8 2019 Anthocyanins have been protective for the kidney parenchyma, with an apparent absence of the tubular and periglomerular necrosis, severe degenerative changes, inflammatory mononuclear infiltrates and dilatation of proximal and distal tubules, in contrast to the CCl4-intoxicated animals. Anthocyanins 0-12 C-C motif chemokine ligand 4 Rattus norvegicus 262-266 30825423-9 2019 The nephroprotective effects of anthocyanins can be explained by strong antioxidant and anti-inflammatory effects achieved through the stabilization and neutralization of highly reactive and unstable toxic CCl4 metabolites. Anthocyanins 32-44 C-C motif chemokine ligand 4 Rattus norvegicus 206-210 31098031-3 2019 Extensive transcript analyses indicate that anthocyanin pigmentation in Pro35S:BrTT8 plants under high light might be coordinately regulated by the exogenous protein BrTT8 and endogenous proteins SlAN2 and SlMYBL2. Anthocyanins 44-55 transcription factor MYB75 Solanum lycopersicum 196-201 31098031-6 2019 Simultaneous overexpression of SlAN2 and BrTT8 activated significant anthocyanin biosynthesis in infiltrated tobacco leaves. Anthocyanins 69-80 transcription factor MYB75 Solanum lycopersicum 31-36 31098031-8 2019 Altogether, these results prove that tissue-specific assemblage of the heterogeneous MYB-bHLH-WD40 complex consisting of SlAN2, BrTT8 and SlAN11 triggers nonuniform anthocyanin accumulation in tomato fruit under high light. Anthocyanins 165-176 R2R3MYB transcription factor 14 Solanum lycopersicum 85-88 31098031-8 2019 Altogether, these results prove that tissue-specific assemblage of the heterogeneous MYB-bHLH-WD40 complex consisting of SlAN2, BrTT8 and SlAN11 triggers nonuniform anthocyanin accumulation in tomato fruit under high light. Anthocyanins 165-176 transcription factor MYB75 Solanum lycopersicum 121-126 30160565-5 2019 In vitro observations have shown anthocyanin- and metabolite-induced activation of endothelial nitric oxide synthase and human vascular cell migration. Anthocyanins 33-44 nitric oxide synthase 3 Homo sapiens 83-116 30856405-6 2019 Additionally, bHLH152, which shows high similarity to Arabidopsis PIF3, is involved in the regulation of anthocyanin. Anthocyanins 105-116 phytochrome interacting factor 3 Arabidopsis thaliana 66-70 31035916-0 2019 Functional MYB transcription factor encoding gene AN2 is associated with anthocyanin biosynthesis in Lycium ruthenicum Murray. Anthocyanins 73-84 transcription factor MYB114-like Nicotiana tabacum 50-53 31035916-5 2019 In the phylogenetic trees, LrAN2 and LbAN2 were found to be closely related to NtAN2, which regulates anthocyanin biosynthesis in tobacco. Anthocyanins 102-113 transcription factor MYB114-like Nicotiana tabacum 79-84 31030450-3 2019 The aim of this study was to investigate whether cyanidin-3-O-glucoside (C3G), a widely distributed anthocyanin, could exert a protective effect against the SS2-mediated inflammatory response, as well as to explore the underlying mechanisms in J774 cells in vitro. Anthocyanins 100-111 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 73-76 30579163-8 2019 Similar expression patterns to that of PtrMYB119 were detected for genes encoding the anthocyanin biosynthetic enzymes chalcone synthase, chalcone flavanone isomerase, flavanone 3-hydroxylase, dihydroflavonol 4-reductase, anthocyanidin synthase, and UFGT (UGT78D2). Anthocyanins 86-97 leucoanthocyanidin dioxygenase Arabidopsis thaliana 222-244 31139371-6 2019 The jam was found to contain high concentrations of polyphenolic compounds (137.0 +- 3.2 mg of gallic acid equivalent/100 g), total flavonoids (128.5 +- 23.0 mg of equivalent/100 g), and total anthocyanins (92.5 +- 4.0 mg of cyanidin equivalent/100 g). Anthocyanins 193-205 F11 receptor Homo sapiens 4-7 30964885-6 2019 Furthermore, Snail and CUX1 expression in various TNBC cell lines was inhibited by muscadine grape skin extract (MSKE, a natural grape product rich in anthocyanins) or Cat L inhibitor (Z-FY-CHO) leading to decreased cell invasion and migration. Anthocyanins 151-163 snail family transcriptional repressor 1 Homo sapiens 13-18 30964885-6 2019 Furthermore, Snail and CUX1 expression in various TNBC cell lines was inhibited by muscadine grape skin extract (MSKE, a natural grape product rich in anthocyanins) or Cat L inhibitor (Z-FY-CHO) leading to decreased cell invasion and migration. Anthocyanins 151-163 cut like homeobox 1 Homo sapiens 23-27 30865451-7 2019 No cyanidin is produced with the natural cis isomer of leucocyanidin, and only traces with the unnatural trans isomer, which suggests that anthocyanidin synthase requires other substrate(s) for the in vivo formation of anthocyanidins. Anthocyanins 219-233 leucoanthocyanidin dioxygenase Vitis vinifera 139-161 30797145-0 2019 Anthocyanins and metabolites from purple rice inhibit IL-1beta-induced matrix metalloproteinases expression in human articular chondrocytes through the NF-kappaB and ERK/MAPK pathway. Anthocyanins 0-12 interleukin 1 beta Homo sapiens 54-62 30797145-0 2019 Anthocyanins and metabolites from purple rice inhibit IL-1beta-induced matrix metalloproteinases expression in human articular chondrocytes through the NF-kappaB and ERK/MAPK pathway. Anthocyanins 0-12 mitogen-activated protein kinase 1 Homo sapiens 166-169 30797145-6 2019 Moreover, protocatechuic acid (PA), the main metabolite of anthocyanin, has chondroprotective potential by reducing glycosaminoglycans and collagen breakdown in IL-1beta/OSM-induced porcine cartilage explants in long-term condition. Anthocyanins 59-70 interleukin 1 beta Homo sapiens 161-169 30797145-10 2019 These findings indicated that anthocyanin in Thai purple rice exhibited anti-inflammatory effects in IL-1beta-stimulated human chondrocytes by inhibiting NF-kappaB and ERK/MAPK signaling pathway. Anthocyanins 30-41 interleukin 1 beta Homo sapiens 101-109 30797145-10 2019 These findings indicated that anthocyanin in Thai purple rice exhibited anti-inflammatory effects in IL-1beta-stimulated human chondrocytes by inhibiting NF-kappaB and ERK/MAPK signaling pathway. Anthocyanins 30-41 mitogen-activated protein kinase 1 Homo sapiens 168-171 30807237-0 2019 Molecular analysis of anthocyanin biosynthesis-related genes reveal BoTT8 associated with purple hypocotyl of broccoli (Brassica oleracea var. Anthocyanins 22-33 transcription factor TT8 Brassica oleracea 68-73 30467611-10 2019 Our results not only contribute to a better understanding of anthocyanin inheritance in B. oleracea, but also provide useful information for future hybrid breeding of purple cultivars through combination of different functional alleles of the BoMYB2 gene. Anthocyanins 61-72 transcription factor MYB114-like Brassica oleracea 243-249 30379343-7 2019 The optimal extraction conditions for anthocyanin and antioxidant activity were found at extraction temperature of 20 C, extraction time of 44.95 min and beta-CD concentration of 45 g L-1 . Anthocyanins 38-49 L1 cell adhesion molecule Homo sapiens 185-188 30935162-5 2019 The results showed that eNOS mRNA levels were significantly upregulated in BCE- or anthocyanin-treated human vascular endothelial cells but decreased in cells treated with fulvestrant, an ER antagonist. Anthocyanins 83-94 nitric oxide synthase 3 Homo sapiens 24-28 30935162-6 2019 These results corresponded with NO levels, suggesting that BCE and anthocyanin may regulate NO synthesis via eNOS expression. Anthocyanins 67-78 nitric oxide synthase 3 Homo sapiens 109-113 30935162-0 2019 Phytoestrogenic Effects of Blackcurrant Anthocyanins Increased Endothelial Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells and Ovariectomized Rats. Anthocyanins 40-52 nitric oxide synthase 3 Homo sapiens 63-96 30935162-0 2019 Phytoestrogenic Effects of Blackcurrant Anthocyanins Increased Endothelial Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells and Ovariectomized Rats. Anthocyanins 40-52 nitric oxide synthase 3 Homo sapiens 98-102 30935162-8 2019 In vivo, we investigated whether anthocyanin-rich BCE upregulated eNOS protein expression in ovariectomized (OVX) rats, a widely used animal model of menopause. Anthocyanins 33-44 nitric oxide synthase 3 Rattus norvegicus 66-70 30935162-9 2019 Our results showed that anthocyanin-rich BCE significantly upregulated eNOS mRNA levels and NO synthesis through phytoestrogenic activity and therefore promoted blood vessel health in OVX rats as a postmenopausal model. Anthocyanins 24-35 nitric oxide synthase 3 Rattus norvegicus 71-75 30813721-8 2019 Anthocyanins suppressed microgliosis and astrocytosis and reduced the overexpression of nuclear factor kappa B (NF-kappaB), interleukin-1-beta (IL-1beta), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha). Anthocyanins 0-12 interleukin 1 beta Rattus norvegicus 124-142 30813721-8 2019 Anthocyanins suppressed microgliosis and astrocytosis and reduced the overexpression of nuclear factor kappa B (NF-kappaB), interleukin-1-beta (IL-1beta), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha). Anthocyanins 0-12 interleukin 1 beta Rattus norvegicus 144-152 30813721-8 2019 Anthocyanins suppressed microgliosis and astrocytosis and reduced the overexpression of nuclear factor kappa B (NF-kappaB), interleukin-1-beta (IL-1beta), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha). Anthocyanins 0-12 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 155-171 30813721-8 2019 Anthocyanins suppressed microgliosis and astrocytosis and reduced the overexpression of nuclear factor kappa B (NF-kappaB), interleukin-1-beta (IL-1beta), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha). Anthocyanins 0-12 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 173-178 30813721-8 2019 Anthocyanins suppressed microgliosis and astrocytosis and reduced the overexpression of nuclear factor kappa B (NF-kappaB), interleukin-1-beta (IL-1beta), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha). Anthocyanins 0-12 tumor necrosis factor Rattus norvegicus 185-212 30813721-8 2019 Anthocyanins suppressed microgliosis and astrocytosis and reduced the overexpression of nuclear factor kappa B (NF-kappaB), interleukin-1-beta (IL-1beta), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha). Anthocyanins 0-12 tumor necrosis factor Rattus norvegicus 214-223 30813721-9 2019 Moreover, anthocyanins lowered C-jun N-terminal kinase ( p-JNK), caspase-3 levels, and the B-cell lymphoma 2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) ratio. Anthocyanins 10-22 mitogen-activated protein kinase 8 Rattus norvegicus 59-62 30813721-9 2019 Moreover, anthocyanins lowered C-jun N-terminal kinase ( p-JNK), caspase-3 levels, and the B-cell lymphoma 2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) ratio. Anthocyanins 10-22 caspase 3 Rattus norvegicus 65-74 30813721-9 2019 Moreover, anthocyanins lowered C-jun N-terminal kinase ( p-JNK), caspase-3 levels, and the B-cell lymphoma 2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) ratio. Anthocyanins 10-22 BCL2 associated X, apoptosis regulator Rattus norvegicus 149-152 30813721-9 2019 Moreover, anthocyanins lowered C-jun N-terminal kinase ( p-JNK), caspase-3 levels, and the B-cell lymphoma 2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) ratio. Anthocyanins 10-22 BCL2, apoptosis regulator Rattus norvegicus 153-158 30813721-10 2019 Thus, anthocyanins from LR attenuated memory disfunction, neuroinflammation, and neurodegeneration caused by d-gal, possibly through the RAGE/NF-kappaB/JNK pathway, representing a promising, safe candidate for prevention and therapy of neurodegenerative diseases. Anthocyanins 6-18 advanced glycosylation end product-specific receptor Rattus norvegicus 137-141 30813721-10 2019 Thus, anthocyanins from LR attenuated memory disfunction, neuroinflammation, and neurodegeneration caused by d-gal, possibly through the RAGE/NF-kappaB/JNK pathway, representing a promising, safe candidate for prevention and therapy of neurodegenerative diseases. Anthocyanins 6-18 mitogen-activated protein kinase 8 Rattus norvegicus 152-155 30885125-3 2019 It is considered that the major regulatory gene for anthocyanin biosynthesis is R2R3 MYB-encoding gene StAN1. Anthocyanins 52-63 transcription factor R2R3-MYB Solanum tuberosum 103-108 30885125-7 2019 Sequence organization of regulatory R2R3 MYB (StAN1, StMYBA1, StMYB113), bHLH (StbHLH1, StJAF13) and WD40 (StWD40) genes potentially controlling anthocyanin biosynthesis has been evaluated. Anthocyanins 145-156 transcription factor MYB113-like Solanum tuberosum 53-60 30885125-7 2019 Sequence organization of regulatory R2R3 MYB (StAN1, StMYBA1, StMYB113), bHLH (StbHLH1, StJAF13) and WD40 (StWD40) genes potentially controlling anthocyanin biosynthesis has been evaluated. Anthocyanins 145-156 transcription factor TT8-like Solanum tuberosum 73-77 30885125-7 2019 Sequence organization of regulatory R2R3 MYB (StAN1, StMYBA1, StMYB113), bHLH (StbHLH1, StJAF13) and WD40 (StWD40) genes potentially controlling anthocyanin biosynthesis has been evaluated. Anthocyanins 145-156 transcription factor GLABRA 3-like Solanum tuberosum 88-95 30885125-7 2019 Sequence organization of regulatory R2R3 MYB (StAN1, StMYBA1, StMYB113), bHLH (StbHLH1, StJAF13) and WD40 (StWD40) genes potentially controlling anthocyanin biosynthesis has been evaluated. Anthocyanins 145-156 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 101-105 30885125-7 2019 Sequence organization of regulatory R2R3 MYB (StAN1, StMYBA1, StMYB113), bHLH (StbHLH1, StJAF13) and WD40 (StWD40) genes potentially controlling anthocyanin biosynthesis has been evaluated. Anthocyanins 145-156 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 107-113 30885125-11 2019 CONCLUSIONS: It was found that StAN1 is the major regulatory gene controlling potato anthocyanin synthesis. Anthocyanins 85-96 transcription factor R2R3-MYB Solanum tuberosum 31-36 30885125-13 2019 It is likely that the sequence organization of StAN1 promoter is important for anthocyanin synthesis control and the development of additional diagnostic markers is necessary. Anthocyanins 79-90 transcription factor R2R3-MYB Solanum tuberosum 47-52 30668350-10 2019 Upon administration of caspase-1 inhibitors, anthocyanin-activated pyroptosis was suppressed and cell viability, migration, and invasion rates concomitantly enhanced. Anthocyanins 45-56 caspase 1 Homo sapiens 23-32 30409612-4 2019 When lycopene was paired with the methoxylated anthocyanins, the anti-inflammatory effect on the inhibition of the cytokine IL-8, which is a pro-inflammatory biomarker, was increased by 15-69% of the expected additive activity, indicating synergistic interaction between the compounds. Anthocyanins 47-59 C-X-C motif chemokine ligand 8 Homo sapiens 124-128 30647106-9 2019 Up-regulation of miR3627/4376 could facilitate anthocyanin accumulation by antagonizing a calcium effector, whereas miR395 and miR399, induced by micronutrient deficiencies known to trigger anthocyanin accumulation, respond positively to UV-B radiation. Anthocyanins 190-201 MIR395a Arabidopsis thaliana 116-122 30875369-0 2019 Regulation of anthocyanin accumulation via MYB75/HAT1/TPL-mediated transcriptional repression. Anthocyanins 14-25 production of anthocyanin pigment 1 Arabidopsis thaliana 43-48 30875369-0 2019 Regulation of anthocyanin accumulation via MYB75/HAT1/TPL-mediated transcriptional repression. Anthocyanins 14-25 Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein Arabidopsis thaliana 49-53 30875369-0 2019 Regulation of anthocyanin accumulation via MYB75/HAT1/TPL-mediated transcriptional repression. Anthocyanins 14-25 Transducin family protein / WD-40 repeat family protein Arabidopsis thaliana 54-57 30875369-4 2019 Here we perform molecular and genetic evidence to display that HAT1 plays a new breaker of anthocyanin accumulation via post-translational regulations of MBW protein complex. Anthocyanins 91-102 Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein Arabidopsis thaliana 63-67 30875369-5 2019 Loss of function of HAT1 in the Arabidopsis seedlings exhibits increased anthocyanin accumulation, whereas overexpression of HAT1 significantly repressed anthocyanin accumulation. Anthocyanins 73-84 Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein Arabidopsis thaliana 20-24 30875369-5 2019 Loss of function of HAT1 in the Arabidopsis seedlings exhibits increased anthocyanin accumulation, whereas overexpression of HAT1 significantly repressed anthocyanin accumulation. Anthocyanins 154-165 Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein Arabidopsis thaliana 125-129 30875369-7 2019 Overexpression of HAT1 suppresses abundant anthocyanin phenotype of pap1-D plant. Anthocyanins 43-54 Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein Arabidopsis thaliana 18-22 30875369-7 2019 Overexpression of HAT1 suppresses abundant anthocyanin phenotype of pap1-D plant. Anthocyanins 43-54 phosphatidic acid phosphatase 1 Arabidopsis thaliana 68-72 30875369-9 2019 Repression activity of HAT1 in regulation of gene expression and anthocyanin accumulation can be abolished by deletion or mutation of the EAR motif 1. Anthocyanins 65-76 Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein Arabidopsis thaliana 23-27 30875369-11 2019 We proposed that HAT1 restrained anthocyanin accumulation by inhibiting the activities of MBW protein complex through blocking the formation of MBW protein complex and recruiting the TPL corepressor to epigenetically modulate the anthocyanin late biosynthetic genes (LBGs). Anthocyanins 33-44 Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein Arabidopsis thaliana 17-21 30875369-11 2019 We proposed that HAT1 restrained anthocyanin accumulation by inhibiting the activities of MBW protein complex through blocking the formation of MBW protein complex and recruiting the TPL corepressor to epigenetically modulate the anthocyanin late biosynthetic genes (LBGs). Anthocyanins 33-44 Transducin family protein / WD-40 repeat family protein Arabidopsis thaliana 183-186 30875369-11 2019 We proposed that HAT1 restrained anthocyanin accumulation by inhibiting the activities of MBW protein complex through blocking the formation of MBW protein complex and recruiting the TPL corepressor to epigenetically modulate the anthocyanin late biosynthetic genes (LBGs). Anthocyanins 230-241 Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein Arabidopsis thaliana 17-21 30875369-11 2019 We proposed that HAT1 restrained anthocyanin accumulation by inhibiting the activities of MBW protein complex through blocking the formation of MBW protein complex and recruiting the TPL corepressor to epigenetically modulate the anthocyanin late biosynthetic genes (LBGs). Anthocyanins 230-241 Transducin family protein / WD-40 repeat family protein Arabidopsis thaliana 183-186 30647106-10 2019 Finally, increases in the abundance of an anthocyanin-regulatory MYB-bHLH-WD40 complex elucidated in Arabidopsis, mediated by UV-B-induced changes in miR156/miR535, could contribute to the observed up-regulation of miR828. Anthocyanins 42-53 MIR828 Arabidopsis thaliana 215-221 30647106-11 2019 In turn, miR828 would regulate the AtMYB113-ortologues MYBA5, A6 and A7 (and thereby anthocyanins) via a widely conserved and previously validated auto-regulatory loop involving miR828 and phasi TAS4abc RNAs. Anthocyanins 85-97 MIR828 Arabidopsis thaliana 9-15 30647106-11 2019 In turn, miR828 would regulate the AtMYB113-ortologues MYBA5, A6 and A7 (and thereby anthocyanins) via a widely conserved and previously validated auto-regulatory loop involving miR828 and phasi TAS4abc RNAs. Anthocyanins 85-97 MIR828 Arabidopsis thaliana 178-184 30837365-12 2019 The accumulation of anthocyanin and inorganic phosphate in the atmbd4 mutant was found to be higher than the wild-type plant. Anthocyanins 20-31 methyl-CPG-binding domain 4 Arabidopsis thaliana 63-69 30597099-0 2019 Identification of Candidate HY5-Dependent and -Independent Regulators of Anthocyanin Biosynthesis in Tomato. Anthocyanins 73-84 transcription factor HY5 Solanum lycopersicum 28-31 31125306-5 2019 The ACN-containing lipsticks were evaluated for their ability to act as ultraviolet (UV) absorbers [a source of sun protection factor (SPF)], free radical scavengers against 2,2-diphenyl-1-picrylhydrazyl (DPPH), and preventers of melanin formation through tyrosinase inhibition. Anthocyanins 4-7 tyrosinase Homo sapiens 256-266 30597099-2 2019 Studies have shown that the bZIP transcription factor HY5 plays a key role in controlling anthocyanin accumulation in response to light. Anthocyanins 90-101 transcription factor HY5 Solanum lycopersicum 54-57 30597099-3 2019 However, in hy5 mutants, residual anthocyanins have been detected, indicating that other regulators exist to regulate anthocyanin biosynthesis in an HY5-independent manner. Anthocyanins 34-46 transcription factor HY5 Solanum lycopersicum 12-15 30597099-3 2019 However, in hy5 mutants, residual anthocyanins have been detected, indicating that other regulators exist to regulate anthocyanin biosynthesis in an HY5-independent manner. Anthocyanins 34-45 transcription factor HY5 Solanum lycopersicum 12-15 30597099-5 2019 The T2 generation of tomato plants homozygous for the null allele of the SlHY5 frameshift mutated by a 1 bp insertion contained a lower anthocyanin content. Anthocyanins 136-147 transcription factor HY5 Solanum lycopersicum 73-78 30597099-6 2019 Transcriptional analysis showed that most of the anthocyanin biosynthesis structural genes and several regulatory genes were down-regulated in the hy5 mutant lines. Anthocyanins 49-60 transcription factor HY5 Solanum lycopersicum 147-150 30597099-7 2019 With transcriptome analyses of the various tissues from hy5 mutant lines, eight candidate transcription factors were identified that may regulate anthocyanin biosynthesis in an HY5-independent manner. Anthocyanins 146-157 transcription factor HY5 Solanum lycopersicum 56-59 30597099-7 2019 With transcriptome analyses of the various tissues from hy5 mutant lines, eight candidate transcription factors were identified that may regulate anthocyanin biosynthesis in an HY5-independent manner. Anthocyanins 146-157 transcription factor HY5 Solanum lycopersicum 177-180 30597099-8 2019 These findings deepen our understanding of how light controls anthocyanin accumulation and facilitate the identification of the regulators of anthocyanin biosynthesis in an HY5-independent manner. Anthocyanins 142-153 transcription factor HY5 Solanum lycopersicum 173-176 30813654-2 2019 Its predominant anthocyanin, cyanidin-3-O-glucoside (C3G), possesses antioxidant and many other potent biological activities. Anthocyanins 16-27 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 53-56 30661219-5 2019 The immune response of interleukin-stimulated cells decreased significantly in a dose-dependent manner in the presence of 20-50 muM/l anthocyanins from all grains extracts, again with a different efficiency. Anthocyanins 134-146 latexin Homo sapiens 128-131 30685697-0 2019 Advance of the negative regulation of anthocyanin biosynthesis by MYB transcription factors. Anthocyanins 38-49 MYB proto-oncogene, transcription factor Homo sapiens 66-69 30685697-4 2019 From model plants to horticultural crops, numerous studies have resulted in the discovery of highly conserved MYB-bHLH-WDR (MBW) transcriptional complex for the regulation of anthocyanin biosynthesis in plants. Anthocyanins 175-186 MYB proto-oncogene, transcription factor Homo sapiens 110-113 30685697-5 2019 Recent discoveries have revealed that the anthocyanin biosynthesis pathway is also controlled by MYB repressors. Anthocyanins 42-53 MYB proto-oncogene, transcription factor Homo sapiens 97-100 30685697-6 2019 Here we focus on the research progress into the role of MYB repressors in anthocyanin biosynthesis. Anthocyanins 74-85 MYB proto-oncogene, transcription factor Homo sapiens 56-59 30685697-8 2019 In addition, an integrated regulatory network of anthocyanin biosynthesis controlled by MYB repressors and MBW activation complex is built based on the significant progress. Anthocyanins 49-60 MYB proto-oncogene, transcription factor Homo sapiens 88-91 30704824-4 2019 The characterized phenylpropanoid R2R3-MYB repressors comprise two phylogenetic clades that act on the lignin and general phenylpropanoid genes, or the flavonoid genes, respectively; anthocyanin R3-MYB repressors form a separate clade. Anthocyanins 183-194 MYB proto-oncogene, transcription factor Homo sapiens 39-42 30704824-4 2019 The characterized phenylpropanoid R2R3-MYB repressors comprise two phylogenetic clades that act on the lignin and general phenylpropanoid genes, or the flavonoid genes, respectively; anthocyanin R3-MYB repressors form a separate clade. Anthocyanins 183-194 MYB proto-oncogene, transcription factor Homo sapiens 198-201 30693917-6 2019 ACN administration significantly reduced serum uric acid (SUA), blood urea nitrogen (BUN) and serum creatinine (Scr) levels and suppressed xanthine oxidase (XOD) activity in mice serum and liver. Anthocyanins 0-3 xanthine dehydrogenase Mus musculus 139-155 30611791-0 2019 Anthocyanins and metabolites resolve TNF-alpha-mediated production of E-selectin and adhesion of monocytes to endothelial cells. Anthocyanins 0-12 tumor necrosis factor Homo sapiens 37-46 30611791-0 2019 Anthocyanins and metabolites resolve TNF-alpha-mediated production of E-selectin and adhesion of monocytes to endothelial cells. Anthocyanins 0-12 selectin E Homo sapiens 70-80 30796303-8 2019 Moreover, the activities of phenylalanine ammonia-lyase (PAL), chalcone isomerase (CHI), UDP glucose: flavonoid 3-o-glucosyl transferase (UFGT) and dihydroflavonol 4-reductase (DFR), key enzymes for biosynthesis of anthocyanin, were increased by the exogenous treatments. Anthocyanins 215-226 peptidylglycine alpha-amidating monooxygenase Homo sapiens 28-55 30796303-8 2019 Moreover, the activities of phenylalanine ammonia-lyase (PAL), chalcone isomerase (CHI), UDP glucose: flavonoid 3-o-glucosyl transferase (UFGT) and dihydroflavonol 4-reductase (DFR), key enzymes for biosynthesis of anthocyanin, were increased by the exogenous treatments. Anthocyanins 215-226 peptidylglycine alpha-amidating monooxygenase Homo sapiens 57-60 30693917-6 2019 ACN administration significantly reduced serum uric acid (SUA), blood urea nitrogen (BUN) and serum creatinine (Scr) levels and suppressed xanthine oxidase (XOD) activity in mice serum and liver. Anthocyanins 0-3 xanthine dehydrogenase Mus musculus 157-160 30781340-5 2019 Importantly, anthocyanin biosynthesis and the activities of several antioxidant enzymes, such as superoxide dismutase (SOD), peroxidase (POD), and ascorbate peroxidase (APX), were enhanced in the SsMAX2 OE lines, which further led to a significant reduction in hydrogen peroxide levels. Anthocyanins 13-24 peroxidase Arabidopsis thaliana 125-135 30781340-5 2019 Importantly, anthocyanin biosynthesis and the activities of several antioxidant enzymes, such as superoxide dismutase (SOD), peroxidase (POD), and ascorbate peroxidase (APX), were enhanced in the SsMAX2 OE lines, which further led to a significant reduction in hydrogen peroxide levels. Anthocyanins 13-24 peroxidase Arabidopsis thaliana 137-140 30781340-5 2019 Importantly, anthocyanin biosynthesis and the activities of several antioxidant enzymes, such as superoxide dismutase (SOD), peroxidase (POD), and ascorbate peroxidase (APX), were enhanced in the SsMAX2 OE lines, which further led to a significant reduction in hydrogen peroxide levels. Anthocyanins 13-24 ascorbate peroxidase 1 Arabidopsis thaliana 147-167 30781340-5 2019 Importantly, anthocyanin biosynthesis and the activities of several antioxidant enzymes, such as superoxide dismutase (SOD), peroxidase (POD), and ascorbate peroxidase (APX), were enhanced in the SsMAX2 OE lines, which further led to a significant reduction in hydrogen peroxide levels. Anthocyanins 13-24 ascorbate peroxidase 1 Arabidopsis thaliana 169-172 30732560-6 2019 And we found two DMR-associated DEGs involved in the anthocyanin pathway: ANS (MD06G1071600) and F3H (MD05G1074200). Anthocyanins 53-64 naringenin,2-oxoglutarate 3-dioxygenase Malus domestica 97-100 30732560-13 2019 However, we observed that the upregulated expression of ANS (MD06G1071600) and F3H (MD05G1074200) in apple mutants results in increased anthocyanin contents. Anthocyanins 136-147 naringenin,2-oxoglutarate 3-dioxygenase Malus domestica 79-82 30239820-0 2019 bHLH92 from sheepgrass acts as a negative regulator of anthocyanin/proanthocyandin accumulation and influences seed dormancy. Anthocyanins 55-66 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 0-6 30160312-7 2019 ZmFNSII expression is controlled by the C1/PL1 + R/B anthocyanin transcriptional complexes, and both ZmFNSI and ZmFNSII are regulated by UV-B. Anthocyanins 53-64 anthocyanin regulatory C1 protein Zea mays 40-52 30500515-7 2019 Transgenic Arabidopsis plants expressing RrGT1 regained red color pigmentation of their leaves and flower stems, indicating that RrGT1 could encode a functional glycosyltransferase (GT) protein for anthocyanin biosynthesis and could function in other species. Anthocyanins 198-209 glycosyltransferase Arabidopsis thaliana 161-180 30500515-7 2019 Transgenic Arabidopsis plants expressing RrGT1 regained red color pigmentation of their leaves and flower stems, indicating that RrGT1 could encode a functional glycosyltransferase (GT) protein for anthocyanin biosynthesis and could function in other species. Anthocyanins 198-209 glycosyltransferase Arabidopsis thaliana 43-45 30634134-0 2019 A novel glutathione S-transferase gene from sweetpotato, IbGSTF4, is involved in anthocyanin sequestration. Anthocyanins 81-92 glutathione S-transferase tau 5 Arabidopsis thaliana 8-33 30634134-3 2019 Previous studies have indicated that glutathione S-transferase (GST) genes from model and ornamental plants are involved in anthocyanin transportation. Anthocyanins 124-135 glutathione S-transferase tau 5 Arabidopsis thaliana 37-62 30634134-3 2019 Previous studies have indicated that glutathione S-transferase (GST) genes from model and ornamental plants are involved in anthocyanin transportation. Anthocyanins 124-135 glutathione S-transferase tau 5 Arabidopsis thaliana 64-67 30634134-4 2019 In the present study, an anthocyanin-related GST, IbGSTF4, was identified and characterized based on transcriptome results. Anthocyanins 25-36 glutathione S-transferase tau 5 Arabidopsis thaliana 45-48 30634134-5 2019 Phylogenetic analysis revealed that IbGSTF4 was most closely correlated to PhAN9 and CkmGST3, the anthocyanin-related GST of Petunia hybrida and Cyclamen. Anthocyanins 98-109 glutathione S-transferase tau 5 Arabidopsis thaliana 38-41 30692585-0 2019 GLUT1 and GLUT3 involvement in anthocyanin gastric transport- Nanobased targeted approach. Anthocyanins 31-42 solute carrier family 2 member 1 Homo sapiens 0-5 30692585-0 2019 GLUT1 and GLUT3 involvement in anthocyanin gastric transport- Nanobased targeted approach. Anthocyanins 31-42 solute carrier family 2 member 3 Homo sapiens 10-15 30692585-3 2019 This study aimed to evaluate the role of two glucose transporters (GLUT1 and GLUT3) in anthocyanins absorption in the human gastric epithelial cells (MKN-28) by using gold nanoparticles to silence these transporters. Anthocyanins 87-99 solute carrier family 2 member 1 Homo sapiens 67-72 30692585-3 2019 This study aimed to evaluate the role of two glucose transporters (GLUT1 and GLUT3) in anthocyanins absorption in the human gastric epithelial cells (MKN-28) by using gold nanoparticles to silence these transporters. Anthocyanins 87-99 solute carrier family 2 member 3 Homo sapiens 77-82 30692585-11 2019 The results support the involvement of GLUT1 and GLUT3 in the gastric absorption of anthocyanins. Anthocyanins 84-96 solute carrier family 2 member 1 Homo sapiens 39-44 30692585-11 2019 The results support the involvement of GLUT1 and GLUT3 in the gastric absorption of anthocyanins. Anthocyanins 84-96 solute carrier family 2 member 3 Homo sapiens 49-54 30679715-0 2019 Transport of Anthocyanins and other Flavonoids by the Arabidopsis ATP-Binding Cassette Transporter AtABCC2. Anthocyanins 13-25 multidrug resistance-associated protein 2 Arabidopsis thaliana 99-106 30679715-3 2019 We also demonstrate that vesicles isolated from yeast expressing the ABC protein AtABCC2 are capable of MgATP-dependent uptake of C3G and other anthocyanins. Anthocyanins 144-156 multidrug resistance-associated protein 2 Arabidopsis thaliana 81-88 30679715-9 2019 In conclusion, we suggest that AtABCC2 along with possibly other ABCC proteins are involved in the vacuolar transport of anthocyanins and other flavonoids in the vegetative tissue of Arabidopsis. Anthocyanins 121-133 multidrug resistance-associated protein 2 Arabidopsis thaliana 31-38 30576129-4 2019 In addition, the relative anthocyanin contents of light-germinated broccoli under SAEW 50 treatment were 2.03 times that of broccoli sprouts with tap water treatment, and these contents were associated with an increase in phenylalanine ammonia lyase (PAL) activities and phenylalanine participation in biosynthesis. Anthocyanins 26-37 peptidylglycine alpha-amidating monooxygenase Homo sapiens 222-249 29993262-6 2019 Besides, anthocyanins exhibited anti-diabetic properties by reducing blood glucose and HbA1c levels or the improvement of insulin secretion and resistance. Anthocyanins 9-21 insulin Homo sapiens 122-129 31830892-5 2019 Furthermore, anthocyanins reduced tumor weight and volume in a colon tumor mouse model and downregulated the expression of PI3K protein, inhibited AKT expression and phosphorylation, decreased the Bcl-2 and Bax ratio and reduced survivin protein expression in the tumor tissue. Anthocyanins 13-25 thymoma viral proto-oncogene 1 Mus musculus 147-150 31830892-5 2019 Furthermore, anthocyanins reduced tumor weight and volume in a colon tumor mouse model and downregulated the expression of PI3K protein, inhibited AKT expression and phosphorylation, decreased the Bcl-2 and Bax ratio and reduced survivin protein expression in the tumor tissue. Anthocyanins 13-25 B cell leukemia/lymphoma 2 Mus musculus 197-202 31830892-5 2019 Furthermore, anthocyanins reduced tumor weight and volume in a colon tumor mouse model and downregulated the expression of PI3K protein, inhibited AKT expression and phosphorylation, decreased the Bcl-2 and Bax ratio and reduced survivin protein expression in the tumor tissue. Anthocyanins 13-25 BCL2-associated X protein Mus musculus 207-210 31830892-5 2019 Furthermore, anthocyanins reduced tumor weight and volume in a colon tumor mouse model and downregulated the expression of PI3K protein, inhibited AKT expression and phosphorylation, decreased the Bcl-2 and Bax ratio and reduced survivin protein expression in the tumor tissue. Anthocyanins 13-25 baculoviral IAP repeat-containing 5 Mus musculus 229-237 31830892-7 2019 Mechanistically, anthocyanins enhanced the Bcl-2/Bax and caspase-dependent apoptotic pathways through targeting the PI3K/AKT/survivin pathway, resulting in impairment of growth of CRC. Anthocyanins 17-29 B cell leukemia/lymphoma 2 Mus musculus 43-48 31830892-7 2019 Mechanistically, anthocyanins enhanced the Bcl-2/Bax and caspase-dependent apoptotic pathways through targeting the PI3K/AKT/survivin pathway, resulting in impairment of growth of CRC. Anthocyanins 17-29 BCL2-associated X protein Mus musculus 49-52 31830892-7 2019 Mechanistically, anthocyanins enhanced the Bcl-2/Bax and caspase-dependent apoptotic pathways through targeting the PI3K/AKT/survivin pathway, resulting in impairment of growth of CRC. Anthocyanins 17-29 thymoma viral proto-oncogene 1 Mus musculus 121-124 31830892-7 2019 Mechanistically, anthocyanins enhanced the Bcl-2/Bax and caspase-dependent apoptotic pathways through targeting the PI3K/AKT/survivin pathway, resulting in impairment of growth of CRC. Anthocyanins 17-29 baculoviral IAP repeat-containing 5 Mus musculus 125-133 30174062-8 2019 In addition, the dihydroflavonol-4-reductase (DFR) is the primary gene that regulates the expression of anthocyanin. Anthocyanins 104-115 putative anthocyanidin reductase Ziziphus jujuba 17-44 30174062-8 2019 In addition, the dihydroflavonol-4-reductase (DFR) is the primary gene that regulates the expression of anthocyanin. Anthocyanins 104-115 putative anthocyanidin reductase Ziziphus jujuba 46-49 29779175-0 2019 Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3beta Signaling in LPS-Treated Adult Mice. Anthocyanins 0-12 mitogen-activated protein kinase 8 Mus musculus 93-96 29779175-0 2019 Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3beta Signaling in LPS-Treated Adult Mice. Anthocyanins 0-12 thymoma viral proto-oncogene 1 Mus musculus 97-100 29779175-0 2019 Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3beta Signaling in LPS-Treated Adult Mice. Anthocyanins 0-12 glycogen synthase kinase 3 beta Mus musculus 101-109 30251280-2 2019 Cyanidin-3-glucoside (C3G), one of the most widely distributed anthocyanins in edible fruits, shows antioxidative and anti-inflammatory property as well as induction of breast cancer cells apoptosis. Anthocyanins 63-75 Rap guanine nucleotide exchange factor 1 Homo sapiens 0-25 31580197-3 2019 In this study, we first found that BIG deficiency significantly sensitized the sugar-induced anthocyanin accumulation and the sugar-inhibited primary root growth, suggesting BIG is an important component of the sugar signaling pathway. Anthocyanins 93-104 auxin transport protein (BIG) Arabidopsis thaliana 35-38 30591695-0 2018 A R2R3-MYB Transcription Factor, VvMYBC2L2, Functions as a Transcriptional Repressor of Anthocyanin Biosynthesis in Grapevine (Vitis vinifera L.). Anthocyanins 88-99 transcription repressor MYB6-like Vitis vinifera 33-42 30591695-2 2018 Here, a R2R3-MYB transcription factor, VvMYBC2L2, isolated from Vitis vinifera cultivar Yatomi Rose, may be involved in anthocyanin biosynthesis as a transcriptional repressor. Anthocyanins 120-131 transcription repressor MYB6-like Vitis vinifera 39-48 30591695-5 2018 Overexpressing the VvMYBC2L2 gene in tobacco resulted in a very marked decrease in petal anthocyanin concentration. Anthocyanins 89-100 transcription repressor MYB6-like Vitis vinifera 19-28 30591695-8 2018 These results suggested that VvMYBC2L2 plays a role as a negative regulator of anthocyanin biosynthesis. Anthocyanins 79-90 transcription repressor MYB6-like Vitis vinifera 29-38 30394469-3 2018 Structural determinants for inhibition of alpha-glucosidase by Pg3R and the SAR of natural anthocyanins were revealed in detail by enzymatic kinetics and molecular docking analysis. Anthocyanins 91-103 sucrase-isomaltase Homo sapiens 42-59 30563462-10 2018 The down-regulation of AACT1, HMGS, HMGR, MVK, MVD2, IDI1 and FPPS2 involved in terpenoid biosynthesis influences anthocyanin accumulation by positively regulating transcripts of AUX1 and SAUR that contribute to the synthesis of IAA, GID2 to GA, PP2C and SnRK2 to ABA. Anthocyanins 114-125 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like Malus domestica 36-40 30402029-2 2018 Cyanidin-3-glucoside (C3G), a component of anthocyanin, has been reported to protect against glutamate-induced neuronal cell death by inhibiting Ca2+ and Zn2+ signaling. Anthocyanins 43-54 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 0-25 30463302-7 2018 These results indicate that stilbenes such as Res and Pter specifically and potently inhibit MTA1 and MTA1-associated proteins compared to GPE, which contains low concentrations of Res and mainly consists of other flavonoids and anthocyanidins. Anthocyanins 229-243 metastasis associated 1 Homo sapiens 102-106 30030201-10 2018 McMYB, a homolog of AtMYB113, induced anthocyanin accumulation in tobacco leaves when co-infiltrated PsbHLH3. Anthocyanins 38-49 myb domain protein 113 Arabidopsis thaliana 20-28 30381205-3 2018 The reduced plasma interleukin (IL)-6 and improved liver health may be mediated by cherry fibre and non-anthocyanin phenolics. Anthocyanins 104-115 interleukin 6 Mus musculus 19-37 30381205-5 2018 Lack of plasma antilipidemic, improvement of antioxidant defenses, and PPARalpha/gamma mRNA modulation in liver suggest cherry anthocyanins specific benefits. Anthocyanins 127-139 peroxisome proliferator activated receptor alpha Mus musculus 71-80 30413758-5 2018 We found that endogenous levels of anthocyanins, members of the flavonoid group, were significantly lower in the aba3 mutant than in the wild type or the aba2 mutant under oxidative stress. Anthocyanins 35-47 NAD(P)-binding Rossmann-fold superfamily protein Arabidopsis thaliana 154-158 30413758-7 2018 Our findings shed light on a key role of ABA3 in the ABA- and allantoin-independent accumulation of anthocyanins during stress responses. Anthocyanins 100-112 molybdenum cofactor sulfurase (LOS5) (ABA3) Arabidopsis thaliana 41-45 30456010-1 2018 This study was conducted to examine the role of the transcription factors (TFs), RsMYB1 and mPAP1 together with B-Peru (mPAP1 + B-Peru), in regulating anthocyanin biosynthesis in the ornamental torenia (Torenia fournieri) cultivar Kauai Rose using Agrobacterium-mediated transformation. Anthocyanins 151-162 regenerating islet-derived 3 beta Mus musculus 92-97 30456010-1 2018 This study was conducted to examine the role of the transcription factors (TFs), RsMYB1 and mPAP1 together with B-Peru (mPAP1 + B-Peru), in regulating anthocyanin biosynthesis in the ornamental torenia (Torenia fournieri) cultivar Kauai Rose using Agrobacterium-mediated transformation. Anthocyanins 151-162 regenerating islet-derived 3 beta Mus musculus 120-125 30456010-4 2018 Anthocyanin structural gene expression was specifically altered by TF overexpression: the highest expression of anthocyanidin synthase (ANS) was observed in transgenic lines with RsMYB1, while expression of dihydroflavonol-4-reductase (DFR) was the highest in lines with mPAP1 + B-Peru. Anthocyanins 0-11 regenerating islet-derived 3 beta Mus musculus 271-276 30456010-6 2018 Moreover, these results indicate that RsMYB1 and mPAP1 + B-Peru can be exploited as anthocyanin regulatory TFs to enhance anthocyanin content in other horticultural plants. Anthocyanins 84-95 regenerating islet-derived 3 beta Mus musculus 49-54 30456010-6 2018 Moreover, these results indicate that RsMYB1 and mPAP1 + B-Peru can be exploited as anthocyanin regulatory TFs to enhance anthocyanin content in other horticultural plants. Anthocyanins 122-133 regenerating islet-derived 3 beta Mus musculus 49-54 30618576-5 2018 Anthocyanin could also markedly ameliorate cerebral edema and reduce the concentration of Evans blue (EB) by inhibiting MMP-9. Anthocyanins 0-11 matrix metallopeptidase 9 Rattus norvegicus 120-125 30618576-7 2018 The levels of inflammation-related molecules including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), which were over-expressed with MCAO/R, were decreased by anthocyanin. Anthocyanins 209-220 interleukin 6 Rattus norvegicus 145-149 30618576-8 2018 In addition, Nuclear factor-kappa B (NF-kappaB) and the NLRP3 inflammasome pathway might be involved in the anti-inflammatory effect of anthocyanin. Anthocyanins 136-147 NLR family, pyrin domain containing 3 Rattus norvegicus 56-61 30521567-2 2018 In the present study, we chose the tomato DFR gene involved in anthocyanin biosynthesis as a landing pad for targeted transgene insertion using CRISPR-Cas9 in a two-step strategy. Anthocyanins 63-74 dihydroflavonol 4-reductase Solanum lycopersicum 42-45 30376326-8 2018 In conclusion, C3G protected against the 3-MCPD caused testis damage and spermatogenic disorders under appropriate doses, which indicates the potential protection of anthocyanins on male reproduction. Anthocyanins 166-178 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 15-18 30411897-4 2018 Anthocyanin- and flavonoid-rich fractions shared similar advantages in preventing the expression of senescence-associated beta-galactosidase (34.8% +- 11.1% and 32.2% +- 9.7% of aged cells, respectively) and overexpression of vascular endothelial growth factor (51.8 +- 3.5 and 54.1 +- 6.5 pg/mL, respectively). Anthocyanins 0-11 galactosidase beta 1 Homo sapiens 122-140 30411897-4 2018 Anthocyanin- and flavonoid-rich fractions shared similar advantages in preventing the expression of senescence-associated beta-galactosidase (34.8% +- 11.1% and 32.2% +- 9.7% of aged cells, respectively) and overexpression of vascular endothelial growth factor (51.8 +- 3.5 and 54.1 +- 6.5 pg/mL, respectively). Anthocyanins 0-11 vascular endothelial growth factor A Homo sapiens 226-260 30375293-0 2018 Effect of purified anthocyanins or anthocyanin-rich extracts on C-reactive protein levels: a systematic review and meta-analysis of randomised clinical trials. Anthocyanins 19-31 C-reactive protein Homo sapiens 64-82 30375293-0 2018 Effect of purified anthocyanins or anthocyanin-rich extracts on C-reactive protein levels: a systematic review and meta-analysis of randomised clinical trials. Anthocyanins 19-30 C-reactive protein Homo sapiens 64-82 30375293-1 2018 As the results of clinical trials are inconsistent, we conducted this research to assess the effect of purified anthocyanins or anthocyanin-rich extract supplementation on C-reactive protein (CRP) levels. Anthocyanins 112-124 C-reactive protein Homo sapiens 172-190 30375293-1 2018 As the results of clinical trials are inconsistent, we conducted this research to assess the effect of purified anthocyanins or anthocyanin-rich extract supplementation on C-reactive protein (CRP) levels. Anthocyanins 112-124 C-reactive protein Homo sapiens 192-195 30375293-1 2018 As the results of clinical trials are inconsistent, we conducted this research to assess the effect of purified anthocyanins or anthocyanin-rich extract supplementation on C-reactive protein (CRP) levels. Anthocyanins 112-123 C-reactive protein Homo sapiens 172-190 30375293-1 2018 As the results of clinical trials are inconsistent, we conducted this research to assess the effect of purified anthocyanins or anthocyanin-rich extract supplementation on C-reactive protein (CRP) levels. Anthocyanins 112-123 C-reactive protein Homo sapiens 192-195 30375293-10 2018 Although changes in CRP concentrations had no association with trial duration, a significant relationship was found between anthocyanin dosage and CRP level. Anthocyanins 124-135 C-reactive protein Homo sapiens 147-150 30316842-5 2018 Consumption of an anthocyanin-rich diet moderately increased the activity and mRNA expression of the studied CYPs by 20-55% relative to the control (with the exception of CYP2B1/2). Anthocyanins 18-29 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 171-177 29769704-2 2018 Anthocyanins and their main metabolite protocatechuic acid (PCA) have been demonstrated to stimulate insulin signaling in human adipocytes. Anthocyanins 0-12 insulin Homo sapiens 101-108 29769704-12 2018 These results support the beneficial role of an anthocyanin-rich diet against inflammation and insulin resistance in obesity. Anthocyanins 48-59 insulin Homo sapiens 95-102 30216785-10 2018 Our results demonstrate that high anthocyanin accumulation in PAP1-D/fls1ko plants confers enhanced tolerance to nitrate-deficient conditions combined with high salinity. Anthocyanins 34-45 lipin 1 Homo sapiens 62-66 29696658-2 2018 VIN stabilizes anthocyanins and preserves polyphenolic compounds, and thus improves chromatic wine properties. Anthocyanins 15-27 long intergenic non-protein coding RNA 1191 Homo sapiens 0-3 30144090-4 2018 DNA binding genes for several transcription factors, such as MYBA1 and MYBA2 haplotype compositions at the color locus are the key determinant of anthocyanin diversity and grape skin color development. Anthocyanins 146-157 MYBA1 Vitis vinifera 61-66 30515320-6 2018 We hypothesize that cyanin chloride, a type of anthocyanin, can inhibit hyperbaric pressure-induced GLAST decreases in cultured rat retinal Muller cells and may serve as a potential neuroprotective agent in glaucoma treatment. Anthocyanins 47-58 solute carrier family 1 member 3 Rattus norvegicus 100-105 30380657-7 2018 Intakes of anthocyanins, catechins, and flavonols were strongly inversely associated with cardiovascular disease risk (anthocyanins: Hazard Ratio (HR)for a 1-point increment of 10 mg/day = 0.98 (0.96-0.99, p = 0.03, HRT3vs.T1 = 0.66 (0.52-0.83), ptrend = 0.0003; catechins: HRfor a 1-point increment of 10 mg/day = 0.98 (0.96-0.99), p = 0.02, HRT3vs.T1 = 0.74 (0.60-0.91), ptrend = 0.004; flavonols: HRfor a 1-point increment of 10 mg/day = 0.94 (0.90-0.99), p = 0.02, HRT3vs.T1 = 0.75 (0.61-0.94), ptrend = 0.006). Anthocyanins 11-23 hes related family bHLH transcription factor with YRPW motif like Homo sapiens 216-220 30380657-7 2018 Intakes of anthocyanins, catechins, and flavonols were strongly inversely associated with cardiovascular disease risk (anthocyanins: Hazard Ratio (HR)for a 1-point increment of 10 mg/day = 0.98 (0.96-0.99, p = 0.03, HRT3vs.T1 = 0.66 (0.52-0.83), ptrend = 0.0003; catechins: HRfor a 1-point increment of 10 mg/day = 0.98 (0.96-0.99), p = 0.02, HRT3vs.T1 = 0.74 (0.60-0.91), ptrend = 0.004; flavonols: HRfor a 1-point increment of 10 mg/day = 0.94 (0.90-0.99), p = 0.02, HRT3vs.T1 = 0.75 (0.61-0.94), ptrend = 0.006). Anthocyanins 11-23 hes related family bHLH transcription factor with YRPW motif like Homo sapiens 343-347 31245687-2 2018 We screened Arabidopsis mutants of ABC (ATP-Binding Cassette) and MATE (Multidrug And Toxic compound Extrusion) transporter genes under nutritional stress and identified four genes (ABCG25,ABCG9,ABCG5, and MATE45) required for normal anthocyanin pigmentation. Anthocyanins 234-245 ATP-binding casette family G25 Arabidopsis thaliana 182-188 31245687-2 2018 We screened Arabidopsis mutants of ABC (ATP-Binding Cassette) and MATE (Multidrug And Toxic compound Extrusion) transporter genes under nutritional stress and identified four genes (ABCG25,ABCG9,ABCG5, and MATE45) required for normal anthocyanin pigmentation. Anthocyanins 234-245 ABC-2 type transporter family protein Arabidopsis thaliana 189-194 31245687-2 2018 We screened Arabidopsis mutants of ABC (ATP-Binding Cassette) and MATE (Multidrug And Toxic compound Extrusion) transporter genes under nutritional stress and identified four genes (ABCG25,ABCG9,ABCG5, and MATE45) required for normal anthocyanin pigmentation. Anthocyanins 234-245 ABC-2 type transporter family protein Arabidopsis thaliana 195-200 30026290-6 2018 The arf7, arf19, and arf7 arf19 mutants showed down-regulated expression of PHR1 and downstream Pi starvation-induced genes in roots; they also exhibited defective Pi uptake in roots and overaccumulation of anthocyanin in shoots. Anthocyanins 207-218 Transcriptional factor B3 family protein / auxin-responsive factor AUX/IAA-like protein Arabidopsis thaliana 4-8 30056145-0 2018 Anthocyanins isolated from blueberry ameliorates CCl4 induced liver fibrosis by modulation of oxidative stress, inflammation and stellate cell activation in mice. Anthocyanins 0-12 chemokine (C-C motif) ligand 4 Mus musculus 49-53 30056145-2 2018 We observed that the levels of serum ALT and AST of 100 mg*kg-1*d-1, 200 mg*kg-1*d-1 anthocyanins group were reduced compared to the CCl4 treated group. Anthocyanins 85-97 glutamic pyruvic transaminase, soluble Mus musculus 37-40 30056145-2 2018 We observed that the levels of serum ALT and AST of 100 mg*kg-1*d-1, 200 mg*kg-1*d-1 anthocyanins group were reduced compared to the CCl4 treated group. Anthocyanins 85-97 chemokine (C-C motif) ligand 4 Mus musculus 133-137 30056145-3 2018 Mitochondrial electron chain complex 1 and 2 activities, determined by microplate assays, were reduced in CCl4 treated group and restored by anthocyanin treatment. Anthocyanins 141-152 chemokine (C-C motif) ligand 4 Mus musculus 106-110 30056145-4 2018 MDA and protein carbonyl content of liver homogenate were induced by CCl4 and anthocyanin treated group reduced both significantly.Monocyte chemoattractant protein 1 (MCP1), Interleukin 1 beta (IL1beta), macrophage inflammatory protein 2 (MIP-2) were induced by CCl4 were attenuated by anthocyanin. Anthocyanins 78-89 chemokine (C-C motif) ligand 2 Mus musculus 131-165 30056145-4 2018 MDA and protein carbonyl content of liver homogenate were induced by CCl4 and anthocyanin treated group reduced both significantly.Monocyte chemoattractant protein 1 (MCP1), Interleukin 1 beta (IL1beta), macrophage inflammatory protein 2 (MIP-2) were induced by CCl4 were attenuated by anthocyanin. Anthocyanins 78-89 chemokine (C-C motif) ligand 2 Mus musculus 167-171 30056145-4 2018 MDA and protein carbonyl content of liver homogenate were induced by CCl4 and anthocyanin treated group reduced both significantly.Monocyte chemoattractant protein 1 (MCP1), Interleukin 1 beta (IL1beta), macrophage inflammatory protein 2 (MIP-2) were induced by CCl4 were attenuated by anthocyanin. Anthocyanins 78-89 interleukin 1 beta Mus musculus 194-201 30056145-4 2018 MDA and protein carbonyl content of liver homogenate were induced by CCl4 and anthocyanin treated group reduced both significantly.Monocyte chemoattractant protein 1 (MCP1), Interleukin 1 beta (IL1beta), macrophage inflammatory protein 2 (MIP-2) were induced by CCl4 were attenuated by anthocyanin. Anthocyanins 78-89 chemokine (C-X-C motif) ligand 2 Mus musculus 204-237 30056145-4 2018 MDA and protein carbonyl content of liver homogenate were induced by CCl4 and anthocyanin treated group reduced both significantly.Monocyte chemoattractant protein 1 (MCP1), Interleukin 1 beta (IL1beta), macrophage inflammatory protein 2 (MIP-2) were induced by CCl4 were attenuated by anthocyanin. Anthocyanins 78-89 chemokine (C-X-C motif) ligand 2 Mus musculus 239-244 30056145-4 2018 MDA and protein carbonyl content of liver homogenate were induced by CCl4 and anthocyanin treated group reduced both significantly.Monocyte chemoattractant protein 1 (MCP1), Interleukin 1 beta (IL1beta), macrophage inflammatory protein 2 (MIP-2) were induced by CCl4 were attenuated by anthocyanin. Anthocyanins 78-89 chemokine (C-C motif) ligand 4 Mus musculus 262-266 30136591-5 2018 Mounting evidence reported that anthocyanins enriched plant foods perform their protective role on IBD and inflammatory-induced colorectal cancer via different cellular transduction signaling pathways, including inflammatory transcription factors, SAPK/JNK and p38 MAPK cascade, JAK/STAT signaling, NF-kB/pERK/MAPK, Wnt signaling pathway, Nrf2 cytoprotective pathway as well as AMPK pathway and autophagy. Anthocyanins 32-44 mitogen-activated protein kinase 14 Homo sapiens 261-264 30136591-5 2018 Mounting evidence reported that anthocyanins enriched plant foods perform their protective role on IBD and inflammatory-induced colorectal cancer via different cellular transduction signaling pathways, including inflammatory transcription factors, SAPK/JNK and p38 MAPK cascade, JAK/STAT signaling, NF-kB/pERK/MAPK, Wnt signaling pathway, Nrf2 cytoprotective pathway as well as AMPK pathway and autophagy. Anthocyanins 32-44 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 305-309 30136591-5 2018 Mounting evidence reported that anthocyanins enriched plant foods perform their protective role on IBD and inflammatory-induced colorectal cancer via different cellular transduction signaling pathways, including inflammatory transcription factors, SAPK/JNK and p38 MAPK cascade, JAK/STAT signaling, NF-kB/pERK/MAPK, Wnt signaling pathway, Nrf2 cytoprotective pathway as well as AMPK pathway and autophagy. Anthocyanins 32-44 NFE2 like bZIP transcription factor 2 Homo sapiens 339-343 30143593-6 2018 Furthermore, ein3-1 suppressed anthocyanin accumulation in yda-1 plants. Anthocyanins 31-42 Ethylene insensitive 3 family protein Arabidopsis thaliana 13-17 30143593-7 2018 Thus, EMB71/YDA-EIN3-EIL1 may form a sugar-mediated gene cascade integral to the regulation of anthocyanin accumulation. Anthocyanins 95-106 Protein kinase superfamily protein Arabidopsis thaliana 6-11 30143593-7 2018 Thus, EMB71/YDA-EIN3-EIL1 may form a sugar-mediated gene cascade integral to the regulation of anthocyanin accumulation. Anthocyanins 95-106 ETHYLENE-INSENSITIVE3-like 1 Arabidopsis thaliana 12-25 30143593-9 2018 Collectively, our data inferred a molecular model where the signaling cascade of the YDA-EIN3-TT8 appeared to target TT8 via EIN3, thereby modulating Suc signaling-mediated anthocyanin accumulation. Anthocyanins 173-184 Ethylene insensitive 3 family protein Arabidopsis thaliana 89-93 30143593-9 2018 Collectively, our data inferred a molecular model where the signaling cascade of the YDA-EIN3-TT8 appeared to target TT8 via EIN3, thereby modulating Suc signaling-mediated anthocyanin accumulation. Anthocyanins 173-184 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 94-97 30143593-9 2018 Collectively, our data inferred a molecular model where the signaling cascade of the YDA-EIN3-TT8 appeared to target TT8 via EIN3, thereby modulating Suc signaling-mediated anthocyanin accumulation. Anthocyanins 173-184 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 117-120 30143593-9 2018 Collectively, our data inferred a molecular model where the signaling cascade of the YDA-EIN3-TT8 appeared to target TT8 via EIN3, thereby modulating Suc signaling-mediated anthocyanin accumulation. Anthocyanins 173-184 Ethylene insensitive 3 family protein Arabidopsis thaliana 125-129 29917151-7 2018 The expression profile analysis of endogenous genes showed that the anthocyanin biosynthesis pathway was activated by two transgenic transcription factor genes ZmC1 and ZmR2. Anthocyanins 68-79 anthocyanin regulatory C1 protein Zea mays 160-164 29917151-7 2018 The expression profile analysis of endogenous genes showed that the anthocyanin biosynthesis pathway was activated by two transgenic transcription factor genes ZmC1 and ZmR2. Anthocyanins 68-79 anthocyanin regulatory R-S protein-like Zea mays 169-173 30274314-10 2018 In oral keratinocytes, ANT treatment significantly restored 5-FU-induced growth inhibition and impaired the nuclear accumulation of NF-kappaB p50 and p65. Anthocyanins 23-26 synaptotagmin 1 Rattus norvegicus 150-153 30294201-6 2018 Results: Bilberry extract and anthocyanins suppressed the aggregation of S-opsin, activation of ATF4, and expression of the mRNA of the factors associated with the unfolded protein response (UPR). Anthocyanins 30-42 opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) Mus musculus 73-80 30107731-3 2018 Anthocyanin dispersions were subjected to up to 120 min of thermal treatment at 80 C. The improvement in the color stability and antioxidant capacity of the anthocyanin dispersions indicated that MRP remarkably inhibited anthocyanin degradation. Anthocyanins 0-11 ATP binding cassette subfamily C member 1 Homo sapiens 197-200 30107731-3 2018 Anthocyanin dispersions were subjected to up to 120 min of thermal treatment at 80 C. The improvement in the color stability and antioxidant capacity of the anthocyanin dispersions indicated that MRP remarkably inhibited anthocyanin degradation. Anthocyanins 158-169 ATP binding cassette subfamily C member 1 Homo sapiens 197-200 30107731-3 2018 Anthocyanin dispersions were subjected to up to 120 min of thermal treatment at 80 C. The improvement in the color stability and antioxidant capacity of the anthocyanin dispersions indicated that MRP remarkably inhibited anthocyanin degradation. Anthocyanins 222-233 ATP binding cassette subfamily C member 1 Homo sapiens 197-200 29935434-5 2018 The anthocyanin biosynthetic genes were highly expressed in the purple genotype, notably the genes TT8, F3H, and MYBL2 under vanadium stress. Anthocyanins 4-15 MYB proto-oncogene like 2 Homo sapiens 113-118 29935434-6 2018 The results indicate that induction of TT8, F3H, and MYBL2 genes was associated with upregulation of the biosynthetic genes required for higher anthocyanin biosynthesis in purple compared with the green mustard. Anthocyanins 144-155 MYB proto-oncogene like 2 Homo sapiens 53-58 30056145-5 2018 Colagen III and alpha-SMA was significantly increased as determined by histology and anthocyanins decreased their level. Anthocyanins 85-97 actin alpha 2, smooth muscle, aorta Mus musculus 16-25 30056145-6 2018 The protein levels of MMP-9, TIMP1 and PCNA of liver homogenate was also modulated by anthocyanins. Anthocyanins 86-98 matrix metallopeptidase 9 Mus musculus 22-27 30056145-6 2018 The protein levels of MMP-9, TIMP1 and PCNA of liver homogenate was also modulated by anthocyanins. Anthocyanins 86-98 tissue inhibitor of metalloproteinase 1 Mus musculus 29-34 30056145-6 2018 The protein levels of MMP-9, TIMP1 and PCNA of liver homogenate was also modulated by anthocyanins. Anthocyanins 86-98 proliferating cell nuclear antigen Mus musculus 39-43 30056145-8 2018 Anthocyanins from blueberry may have protective effects on CCl4 induced hepatic fibrosis. Anthocyanins 0-12 chemokine (C-C motif) ligand 4 Mus musculus 59-63 29981721-5 2018 Plants silenced for TPK3 expression displayed light stress signatures, with reduced Non Photochemical Quenching (NPQ) capacity and sustained anthocyanin accumulation, even at moderate intensities. Anthocyanins 141-152 Ca2+ activated outward rectifying K+ channel 6 Arabidopsis thaliana 20-24 29981721-6 2018 In this work we re-examined the role of this protein in pmf regulation, starting from the observation that both TPK3 knock-down (TPK3 KD) and WT plants display enhanced anthocyanin accumulation in the light under certain growth conditions, especially in old leaves. Anthocyanins 169-180 Ca2+ activated outward rectifying K+ channel 6 Arabidopsis thaliana 112-116 30070707-4 2018 One metabolic transformation is due to the enzyme catechol-O-methyltransferase (COMT), which methylates polyphenols such as anthocyanins. Anthocyanins 124-136 catechol-O-methyltransferase Homo sapiens 50-78 30070707-4 2018 One metabolic transformation is due to the enzyme catechol-O-methyltransferase (COMT), which methylates polyphenols such as anthocyanins. Anthocyanins 124-136 catechol-O-methyltransferase Homo sapiens 80-84 29879604-4 2018 RNA-seq revealed a complete set of genes necessary for anthocyanin biosynthesis and transport, including anthocyanidin 3-O-glucosyltransferase and glutathione S-transferase. Anthocyanins 55-66 glutathione S-transferase kappa 1 Homo sapiens 147-172 30037596-0 2018 Ferulic acid may target MyD88-mediated pro-inflammatory signaling - Implications for the health protection afforded by whole grains, anthocyanins, and coffee. Anthocyanins 133-145 MYD88 innate immune signal transduction adaptor Homo sapiens 24-29 30026290-6 2018 The arf7, arf19, and arf7 arf19 mutants showed down-regulated expression of PHR1 and downstream Pi starvation-induced genes in roots; they also exhibited defective Pi uptake in roots and overaccumulation of anthocyanin in shoots. Anthocyanins 207-218 auxin response factor 19 Arabidopsis thaliana 10-15 30026290-6 2018 The arf7, arf19, and arf7 arf19 mutants showed down-regulated expression of PHR1 and downstream Pi starvation-induced genes in roots; they also exhibited defective Pi uptake in roots and overaccumulation of anthocyanin in shoots. Anthocyanins 207-218 Transcriptional factor B3 family protein / auxin-responsive factor AUX/IAA-like protein Arabidopsis thaliana 21-25 30026290-6 2018 The arf7, arf19, and arf7 arf19 mutants showed down-regulated expression of PHR1 and downstream Pi starvation-induced genes in roots; they also exhibited defective Pi uptake in roots and overaccumulation of anthocyanin in shoots. Anthocyanins 207-218 auxin response factor 19 Arabidopsis thaliana 26-31 30167900-0 2018 Roles of R2R3-MYB transcription factors in transcriptional regulation of anthocyanin biosynthesis in horticultural plants. Anthocyanins 73-84 MYB proto-oncogene, transcription factor Homo sapiens 14-17 30167900-1 2018 KEY MESSAGE: This review contains functional roles of MYB transcription factors in the transcriptional regulation of anthocyanin biosynthesis in horticultural plants. Anthocyanins 117-128 MYB proto-oncogene, transcription factor Homo sapiens 54-57 30167900-2 2018 This review describes potential uses of MYB TFs as tools for metabolic engineering for anthocyanin production. Anthocyanins 87-98 MYB proto-oncogene, transcription factor Homo sapiens 40-43 30167900-4 2018 In the present review, we describe which R2R3-MYB transcription factors (TFs) control the transcriptional regulation of anthocyanin structural genes involved in the specific branches of the anthocyanin biosynthetic pathway in various horticultural plants (e.g., ornamentals, fruits, and vegetables). Anthocyanins 120-131 MYB proto-oncogene, transcription factor Homo sapiens 46-49 30167900-4 2018 In the present review, we describe which R2R3-MYB transcription factors (TFs) control the transcriptional regulation of anthocyanin structural genes involved in the specific branches of the anthocyanin biosynthetic pathway in various horticultural plants (e.g., ornamentals, fruits, and vegetables). Anthocyanins 190-201 MYB proto-oncogene, transcription factor Homo sapiens 46-49 30177937-0 2018 Overexpression of a Phosphate Starvation Response AP2/ERF Gene From Physic Nut in Arabidopsis Alters Root Morphological Traits and Phosphate Starvation-Induced Anthocyanin Accumulation. Anthocyanins 160-171 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 50-53 30158941-1 2018 The co-expression of Rosea1 (Ros1) and Delila (Del) regulates anthocyanin levels in snapdragon flowers, as well as in tomato, petunia, and tobacco. Anthocyanins 62-73 protein ROS1-like Nicotiana tabacum 29-33 30158941-8 2018 Overall, the results obtained here suggest that Ros1 overexpression upregulates anthocyanin biosynthetic, antioxidant-related, and stress-responsive genes thereby enhancing anthocyanin accumulation and abiotic stress tolerance. Anthocyanins 80-91 protein ROS1-like Nicotiana tabacum 48-52 30158941-8 2018 Overall, the results obtained here suggest that Ros1 overexpression upregulates anthocyanin biosynthetic, antioxidant-related, and stress-responsive genes thereby enhancing anthocyanin accumulation and abiotic stress tolerance. Anthocyanins 173-184 protein ROS1-like Nicotiana tabacum 48-52 30106986-12 2018 We found that anthocyanins contributed to suppression of ROS and p53, in association with increased NO production and eNOS dimerization. Anthocyanins 14-26 transformation related protein 53, pseudogene Mus musculus 65-68 29566255-0 2018 The bZip transcription factor HY5 mediates CRY1a-induced anthocyanin biosynthesis in tomato. Anthocyanins 57-68 transcription factor HY5 Solanum lycopersicum 30-33 30110956-4 2018 The concentration of lutein when it was used in combination with anthocyanins was 25-54% higher than when lutein was used alone (i.e., IC50 = 1.2 muM) to induce 50% of lipoxygenase inhibition. Anthocyanins 65-77 latexin Homo sapiens 146-149 30110956-7 2018 The presence of anthocyanins (5-7.5 muM) did not affect lutein uptake (2.5-5 muM) by Caco-2 cells. Anthocyanins 16-28 latexin Homo sapiens 36-39 29800916-1 2018 In this study, the anthocyanin from Lonicera caerulea "Beilei" fruit (ABL) was extracted and purified. Anthocyanins 19-30 c-abl oncogene 1, non-receptor tyrosine kinase Mus musculus 70-73 29566255-0 2018 The bZip transcription factor HY5 mediates CRY1a-induced anthocyanin biosynthesis in tomato. Anthocyanins 57-68 cryptochrome 1 Solanum lycopersicum 43-48 29566255-2 2018 In this study, we found that exposure to blue light and overexpression of CRY1a are associated with increased accumulation of anthocyanin in tomato (Solanum lycopersicum L.). Anthocyanins 126-137 cryptochrome 1 Solanum lycopersicum 74-79 29566255-4 2018 In vitro and in vivo experiments using electrophoretic mobility shift assay and ChIP-qPCR assays revealed that SlHY5 could directly recognize and bind to the G-box and ACGT-containing element in the promoters of anthocyanin biosynthesis genes, such as chalcone synthase 1, chalcone synthase 2, and dihydroflavonol 4-reductase. Anthocyanins 212-223 transcription factor HY5 Solanum lycopersicum 111-116 29566255-5 2018 Silencing of SlHY5 in OE-CRY1a lines decreased the accumulation of anthocyanin. Anthocyanins 67-78 transcription factor HY5 Solanum lycopersicum 13-18 29566255-5 2018 Silencing of SlHY5 in OE-CRY1a lines decreased the accumulation of anthocyanin. Anthocyanins 67-78 cryptochrome 1 Solanum lycopersicum 25-30 30036952-0 2018 Protection of Anthocyanin from Myrica rubra against Cerebral Ischemia-Reperfusion Injury via Modulation of the TLR4/NF-kappaB and NLRP3 Pathways. Anthocyanins 14-25 toll-like receptor 4 Mus musculus 111-115 30036952-0 2018 Protection of Anthocyanin from Myrica rubra against Cerebral Ischemia-Reperfusion Injury via Modulation of the TLR4/NF-kappaB and NLRP3 Pathways. Anthocyanins 14-25 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 116-125 30036952-0 2018 Protection of Anthocyanin from Myrica rubra against Cerebral Ischemia-Reperfusion Injury via Modulation of the TLR4/NF-kappaB and NLRP3 Pathways. Anthocyanins 14-25 NLR family, pyrin domain containing 3 Mus musculus 130-135 30061912-6 2018 The positive effects of HRW on activity of anthocyanin biosynthetic-enzymes (L-phenylalanine ammonia-lyase, PAL; chalcone isomerase, CHI; dihydroflavonol 4-reductase, DFR and UDP glc-flavonoid 3-O-glucosyl transferase, UFGT) were reversed by EGTA and neomycin. Anthocyanins 43-54 dihydroflavonol-4-reductase Raphanus sativus 167-170 29995924-1 2018 The objective of this study was to evaluate the ability of anthocyanins (ANC) present in purple corn to enhance insulin secretion and hepatic glucose uptake in pancreatic cells and hepatocytes, through activation of the free fatty acid receptor-1 (FFAR1) and glucokinase (GK), respectively. Anthocyanins 59-71 free fatty acid receptor 1 Homo sapiens 248-253 29995924-1 2018 The objective of this study was to evaluate the ability of anthocyanins (ANC) present in purple corn to enhance insulin secretion and hepatic glucose uptake in pancreatic cells and hepatocytes, through activation of the free fatty acid receptor-1 (FFAR1) and glucokinase (GK), respectively. Anthocyanins 73-76 free fatty acid receptor 1 Homo sapiens 248-253 29995924-7 2018 D3G was the most effective anthocyanin activating FFAR1 (EC50: 196.6 muM). Anthocyanins 27-38 free fatty acid receptor 1 Homo sapiens 50-55 29995924-7 2018 D3G was the most effective anthocyanin activating FFAR1 (EC50: 196.6 muM). Anthocyanins 27-38 latexin Homo sapiens 69-72 29973639-5 2018 Compared to wild type seedlings, the snd1 knockout mutant seedlings accumulated less anthocyanin and exhibited low tolerance to salt stress. Anthocyanins 85-96 NAC domain containing protein 12 Arabidopsis thaliana 37-41 29556751-0 2018 Anthocyanins from black soybean seed coat prevent radiation-induced skin fibrosis by downregulating TGF-beta and Smad3 expression. Anthocyanins 0-12 transforming growth factor, beta 1 Mus musculus 100-108 29556751-0 2018 Anthocyanins from black soybean seed coat prevent radiation-induced skin fibrosis by downregulating TGF-beta and Smad3 expression. Anthocyanins 0-12 SMAD family member 3 Mus musculus 113-118 29556751-8 2018 In dermal fibroblasts, treatment with 50 and 100 microg/mL anthocyanins significantly reduced radiation-induced apoptosis at 72 h and intracellular reactive oxygen species generation at 48 h. Furthermore, 100 microg/mL anthocyanins markedly decreased Smad3 mRNA expression and increased Smad7 mRNA expression at 72 h post-irradiation. Anthocyanins 59-71 SMAD family member 3 Mus musculus 251-256 29556751-8 2018 In dermal fibroblasts, treatment with 50 and 100 microg/mL anthocyanins significantly reduced radiation-induced apoptosis at 72 h and intracellular reactive oxygen species generation at 48 h. Furthermore, 100 microg/mL anthocyanins markedly decreased Smad3 mRNA expression and increased Smad7 mRNA expression at 72 h post-irradiation. Anthocyanins 59-71 SMAD family member 7 Mus musculus 287-292 29556751-8 2018 In dermal fibroblasts, treatment with 50 and 100 microg/mL anthocyanins significantly reduced radiation-induced apoptosis at 72 h and intracellular reactive oxygen species generation at 48 h. Furthermore, 100 microg/mL anthocyanins markedly decreased Smad3 mRNA expression and increased Smad7 mRNA expression at 72 h post-irradiation. Anthocyanins 219-231 SMAD family member 3 Mus musculus 251-256 29556751-8 2018 In dermal fibroblasts, treatment with 50 and 100 microg/mL anthocyanins significantly reduced radiation-induced apoptosis at 72 h and intracellular reactive oxygen species generation at 48 h. Furthermore, 100 microg/mL anthocyanins markedly decreased Smad3 mRNA expression and increased Smad7 mRNA expression at 72 h post-irradiation. Anthocyanins 219-231 SMAD family member 7 Mus musculus 287-292 29556751-10 2018 Treatment with 100 microg/mL anthocyanins significantly decreased the number of alpha-SMA-, TGF-beta-, and Smad3-positive cells after irradiation. Anthocyanins 29-41 actin alpha 2, smooth muscle, aorta Mus musculus 80-91 29556751-10 2018 Treatment with 100 microg/mL anthocyanins significantly decreased the number of alpha-SMA-, TGF-beta-, and Smad3-positive cells after irradiation. Anthocyanins 29-41 transforming growth factor, beta 1 Mus musculus 92-100 29556751-10 2018 Treatment with 100 microg/mL anthocyanins significantly decreased the number of alpha-SMA-, TGF-beta-, and Smad3-positive cells after irradiation. Anthocyanins 29-41 SMAD family member 3 Mus musculus 107-112 29556751-11 2018 Our study demonstrated that black soybean anthocyanins inhibited radiation-induced fibrosis by downregulating TGF-beta and Smad3 expression. Anthocyanins 42-54 transforming growth factor, beta 1 Mus musculus 110-118 29556751-11 2018 Our study demonstrated that black soybean anthocyanins inhibited radiation-induced fibrosis by downregulating TGF-beta and Smad3 expression. Anthocyanins 42-54 SMAD family member 3 Mus musculus 123-128 29864902-2 2018 Cyanidin 3-glucoside (C3G) is the most widespread anthocyanin in nature. Anthocyanins 50-61 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 0-25 29372433-0 2018 The heterologous expression of Arabidopsis PAP2 induces anthocyanin accumulation and inhibits plant growth in tomato. Anthocyanins 56-67 Purple acid phosphatases superfamily protein Arabidopsis thaliana 43-47 29915353-3 2018 A combined metabolomic and transcriptomic characterization of NO-deficient nia1,2noa1-2 mutant plants suggests that NO acts attenuating the production and accumulation of osmoprotective and regulatory metabolites, such as sugars and polyamines, stress-related hormones, such as ABA and jasmonates, and antioxidants, such as anthocyanins and flavonoids. Anthocyanins 324-336 P-loop containing nucleoside triphosphate hydrolases superfamily protein Arabidopsis thaliana 81-85 29880890-7 2018 Molecular analysis revealed an increased transcription of four key genes in anthocyanin biosynthesis (CHS3, F3H1, MYBA1 and UFGT) in TV treatment. Anthocyanins 76-87 chalcone synthase 2 Vitis vinifera 102-106 29880890-7 2018 Molecular analysis revealed an increased transcription of four key genes in anthocyanin biosynthesis (CHS3, F3H1, MYBA1 and UFGT) in TV treatment. Anthocyanins 76-87 MYBA1 Vitis vinifera 114-119 29880890-7 2018 Molecular analysis revealed an increased transcription of four key genes in anthocyanin biosynthesis (CHS3, F3H1, MYBA1 and UFGT) in TV treatment. Anthocyanins 76-87 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 124-128 29865234-0 2018 Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function. Anthocyanins 32-44 insulin like growth factor 1 Homo sapiens 159-187 29865234-3 2018 Parkinson disease patients score lower on Hospital-associated Anxiety and Depression Scale after supplementing blackcurrant anthocyanins (BCA), which may be associated with IGF-1 function. Anthocyanins 124-136 insulin like growth factor 1 Homo sapiens 173-178 29872532-7 2018 Our results indicated that low level of anthocyanins in tomato fruits, with low expression of bHLH (SlTT8) and MYB (SlANT1 and SlAN2) genes, remain unchanged upon modification of SlAN11 gene alone in the transgenic lines. Anthocyanins 40-52 R2R3MYB transcription factor 14 Solanum lycopersicum 111-114 29872532-7 2018 Our results indicated that low level of anthocyanins in tomato fruits, with low expression of bHLH (SlTT8) and MYB (SlANT1 and SlAN2) genes, remain unchanged upon modification of SlAN11 gene alone in the transgenic lines. Anthocyanins 40-52 anthocyanin 1 Solanum lycopersicum 116-122 29872532-7 2018 Our results indicated that low level of anthocyanins in tomato fruits, with low expression of bHLH (SlTT8) and MYB (SlANT1 and SlAN2) genes, remain unchanged upon modification of SlAN11 gene alone in the transgenic lines. Anthocyanins 40-52 transcription factor MYB75 Solanum lycopersicum 127-132 29739331-6 2018 RESULTS: BoMYBL2-1 is one of the regulatory genes in the anthocyanin biosynthesis pathway in cabbages. Anthocyanins 57-68 myb-related protein 308 Brassica oleracea 9-18 29739331-10 2018 The finding that the defect in BoMYBL2-1 expression was solely responsible for purple coloration in cabbages was further demonstrated using genomic PCR and RT-PCR analyses of many other structural and regulatory genes in anthocyanin biosynthesis. Anthocyanins 221-232 myb-related protein 308 Brassica oleracea 31-40 29739331-12 2018 CONCLUSION: Expression of BoMYBL2-1 was inversely correlated to anthocyanin content, and purple color in cabbages resulted from a loss of BoMYBL2-1 expression, caused by either the promoter substitution or deletion of the gene. Anthocyanins 64-75 myb-related protein 308 Brassica oleracea 26-35 30788932-5 2018 CONCLUSIONS: The results show that anthocyanins has an analgesic effect on chronic inflammatory pain induced by CFA, and its mechanism may be related to the improvement of antioxidant capacity and the reduction of TRPV1 phosphorylation. Anthocyanins 35-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 214-219 29372433-4 2018 The expression of anthocyanin biosynthetic genes and an anthocyanin-related basic helix-loop-helix (bHLH) gene SlAN1 was significantly increased in the transgenic line, suggesting that ectopic expression of AtPAP2 increases the expression of anthocyanin-related structural and regulatory genes to enhance anthocyanin content. Anthocyanins 56-67 Purple acid phosphatases superfamily protein Arabidopsis thaliana 207-213 29372433-4 2018 The expression of anthocyanin biosynthetic genes and an anthocyanin-related basic helix-loop-helix (bHLH) gene SlAN1 was significantly increased in the transgenic line, suggesting that ectopic expression of AtPAP2 increases the expression of anthocyanin-related structural and regulatory genes to enhance anthocyanin content. Anthocyanins 56-67 Purple acid phosphatases superfamily protein Arabidopsis thaliana 207-213 29372433-4 2018 The expression of anthocyanin biosynthetic genes and an anthocyanin-related basic helix-loop-helix (bHLH) gene SlAN1 was significantly increased in the transgenic line, suggesting that ectopic expression of AtPAP2 increases the expression of anthocyanin-related structural and regulatory genes to enhance anthocyanin content. Anthocyanins 56-67 Purple acid phosphatases superfamily protein Arabidopsis thaliana 207-213 29372433-5 2018 Yeast two-hybrid assays revealed that the endogenous MYB protein SlAN2 interacted with two putative bHLH partners, SlAN1 and SlJAF13, while AtPAP2 only interacted with SlJAF13, which may be why AtPAP2 transgenic plants showed limited anthocyanin accumulation in fruits. Anthocyanins 234-245 R2R3MYB transcription factor 14 Solanum lycopersicum 53-56 29372433-5 2018 Yeast two-hybrid assays revealed that the endogenous MYB protein SlAN2 interacted with two putative bHLH partners, SlAN1 and SlJAF13, while AtPAP2 only interacted with SlJAF13, which may be why AtPAP2 transgenic plants showed limited anthocyanin accumulation in fruits. Anthocyanins 234-245 transcription factor MYB75 Solanum lycopersicum 65-70 29372433-9 2018 Taken together, the results demonstrate that heterologous expression of transcription factor AtPAP2 not only resulted in anthocyanin accumulation but also inhibited plant growth in tomato. Anthocyanins 121-132 Purple acid phosphatases superfamily protein Arabidopsis thaliana 93-99 29668036-8 2018 The results showed that grape seeds were rich in anthocyanins and polyphenols and other active substances, inhibited alpha-glucosidase and alpha-amylase activity, which provide background and practical knowledge for the deep-processed products of grape seeds with high added value. Anthocyanins 49-61 sucrase-isomaltase Homo sapiens 117-134 29474693-4 2018 Genes in the ethylene response factor (ERF), SPL, NAC, WRKY and MADS-box transcription factor (TF) families were identified in two weighted gene co-expression network analysis (WGCNA) modules as having a close relationship to anthocyanin accumulation. Anthocyanins 226-237 ETS2 repressor factor Homo sapiens 13-37 29474693-4 2018 Genes in the ethylene response factor (ERF), SPL, NAC, WRKY and MADS-box transcription factor (TF) families were identified in two weighted gene co-expression network analysis (WGCNA) modules as having a close relationship to anthocyanin accumulation. Anthocyanins 226-237 ETS2 repressor factor Homo sapiens 39-42 29474693-4 2018 Genes in the ethylene response factor (ERF), SPL, NAC, WRKY and MADS-box transcription factor (TF) families were identified in two weighted gene co-expression network analysis (WGCNA) modules as having a close relationship to anthocyanin accumulation. Anthocyanins 226-237 sphingosine-1-phosphate lyase 1 Homo sapiens 45-48 29474693-4 2018 Genes in the ethylene response factor (ERF), SPL, NAC, WRKY and MADS-box transcription factor (TF) families were identified in two weighted gene co-expression network analysis (WGCNA) modules as having a close relationship to anthocyanin accumulation. Anthocyanins 226-237 synuclein alpha Homo sapiens 50-53 29474693-5 2018 Analyses of network hub genes indicated that SPL TFs are located in central positions within anthocyanin-related modules. Anthocyanins 93-104 sphingosine-1-phosphate lyase 1 Homo sapiens 45-48 29675814-0 2018 The zinc-finger transcription factor ZAT6 is essential for hydrogen peroxide induction of anthocyanin synthesis in Arabidopsis. Anthocyanins 90-101 6 Arabidopsis thaliana 37-41 29675814-4 2018 Furthermore, we found that the transcript level of ZINC FINGER of ARABIDOPSIS THALIANA 6 (ZAT6) was significantly activated after exogenous H2O2 treatment, and modulation of AtZAT6 expression positively affected the concentrations of both anthocyanin and total flavonoids. Anthocyanins 239-250 6 Arabidopsis thaliana 90-94 29675814-4 2018 Furthermore, we found that the transcript level of ZINC FINGER of ARABIDOPSIS THALIANA 6 (ZAT6) was significantly activated after exogenous H2O2 treatment, and modulation of AtZAT6 expression positively affected the concentrations of both anthocyanin and total flavonoids. Anthocyanins 239-250 6 Arabidopsis thaliana 174-180 29675814-5 2018 Notably, exogenous H2O2-induced anthocyanin synthesis was largely alleviated in AtZAT6 knockdown plants, but showed higher level in AtZAT6 overexpressing plants. Anthocyanins 32-43 6 Arabidopsis thaliana 80-86 29675814-7 2018 Taken together, this study indicates that AtZAT6 plays important role in H2O2-activated anthocyanin synthesis, via directly binding to the promoters of several genes that involved in anthocyanin synthesis. Anthocyanins 88-99 6 Arabidopsis thaliana 42-48 29675814-7 2018 Taken together, this study indicates that AtZAT6 plays important role in H2O2-activated anthocyanin synthesis, via directly binding to the promoters of several genes that involved in anthocyanin synthesis. Anthocyanins 183-194 6 Arabidopsis thaliana 42-48 29487277-11 2018 Therefore, the sucrose responsive AtMyb56 regulates AtGPT2 gene expression in a sucrose-dependent manner to modulate maltose and anthocyanin accumulations in response to the circadian cycle. Anthocyanins 129-140 myb domain protein 56 Arabidopsis thaliana 34-41 29487277-11 2018 Therefore, the sucrose responsive AtMyb56 regulates AtGPT2 gene expression in a sucrose-dependent manner to modulate maltose and anthocyanin accumulations in response to the circadian cycle. Anthocyanins 129-140 glucose-6-phosphate/phosphate translocator 2 Arabidopsis thaliana 52-58 29170981-0 2018 Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer"s Disease. Anthocyanins 35-47 thymoma viral proto-oncogene 1 Mus musculus 57-60 29170981-0 2018 Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer"s Disease. Anthocyanins 35-47 nuclear factor, erythroid derived 2, like 2 Mus musculus 61-65 29170981-0 2018 Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer"s Disease. Anthocyanins 35-47 heme oxygenase 1 Mus musculus 66-70 29170981-2 2018 Herein, we investigated the underlying anti-oxidant neuroprotective mechanism of natural dietary supplementation of anthocyanins extracted from Korean black beans in the amyloid precursor protein/presenilin-1 (APP/PS1) mouse model of AD. Anthocyanins 116-128 amyloid beta (A4) precursor protein Mus musculus 170-195 29170981-2 2018 Herein, we investigated the underlying anti-oxidant neuroprotective mechanism of natural dietary supplementation of anthocyanins extracted from Korean black beans in the amyloid precursor protein/presenilin-1 (APP/PS1) mouse model of AD. Anthocyanins 116-128 presenilin 1 Mus musculus 196-208 29170981-2 2018 Herein, we investigated the underlying anti-oxidant neuroprotective mechanism of natural dietary supplementation of anthocyanins extracted from Korean black beans in the amyloid precursor protein/presenilin-1 (APP/PS1) mouse model of AD. Anthocyanins 116-128 presenilin 1 Mus musculus 214-217 29170981-4 2018 In vitro ApoTox-Glo Triplex assay results also showed that anthocyanins act as a potent anti-oxidant neuroprotective agent and reduce AbetaO-induced neurotoxicity in the HT22 cells via PI3K/Akt/Nrf2 signaling. Anthocyanins 60-72 thymoma viral proto-oncogene 1 Mus musculus 191-194 29170981-4 2018 In vitro ApoTox-Glo Triplex assay results also showed that anthocyanins act as a potent anti-oxidant neuroprotective agent and reduce AbetaO-induced neurotoxicity in the HT22 cells via PI3K/Akt/Nrf2 signaling. Anthocyanins 60-72 nuclear factor, erythroid derived 2, like 2 Mus musculus 195-199 29170981-5 2018 Importantly, anthocyanins improve memory-related pre- and postsynaptic protein markers and memory functions in the APP/PS1 mice. Anthocyanins 13-25 presenilin 1 Mus musculus 119-122 28276271-0 2018 An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Anthocyanins 3-14 superoxide dismutase 1 Homo sapiens 99-104 29235191-2 2018 We investigated the effects of cyanidin-3-o-glucoside (C3G), a monomer of anthocyanin, on UVA-induced damage in primary human dermal fibroblasts (HDFs), and we identify possible mechanisms underlying the protective effects of this compound. Anthocyanins 74-85 Rap guanine nucleotide exchange factor 1 Homo sapiens 55-58 29478524-6 2018 Anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, were strong inhibitors of alpha-amylase and alpha-glucosidase. Anthocyanins 0-12 sucrase-isomaltase Homo sapiens 106-123 29870233-3 2018 The main differences were observed in the flavylium cation (AH+)/quinoidal base (A) equilibrium, the AH+ form being more stabilized than A (p Ka1 = 4.4 +- 0.1) compared with 1 in the absence of the lignosulfonate (p Ka1 = 3.9 +- 0.1). Anthocyanins 42-51 glutamate ionotropic receptor kainate type subunit 4 Homo sapiens 142-145 29940863-3 2018 CSN5a, encoding COP9 signalosome subunit 5a, has also been implicated in trichome and anthocyanin production; however, the regulatory roles of CSN5a in the processes through interaction with the tri-protein complex has yet to be investigated. Anthocyanins 86-97 COP9 signalosome 5A Arabidopsis thaliana 0-5 29940863-3 2018 CSN5a, encoding COP9 signalosome subunit 5a, has also been implicated in trichome and anthocyanin production; however, the regulatory roles of CSN5a in the processes through interaction with the tri-protein complex has yet to be investigated. Anthocyanins 86-97 COP9 signalosome, subunit CSN8 Arabidopsis thaliana 16-20 29940863-6 2018 Seed metabolite analysis revealed that defective CSN5a led to an enhanced production of many compounds in addition to anthocyanin, most notably phenylpropanoids and carotenoids as well as a glycoside of zeatin. Anthocyanins 118-129 COP9 signalosome 5A Arabidopsis thaliana 49-54 29940863-13 2018 Enhanced anthocyanin accumulation and reduced trichome production were related to the enhanced MYB75 and suppressed GL2 and some other differentially expressed genes associated with the TTG1/bHLH/MYB complexes. Anthocyanins 9-20 production of anthocyanin pigment 1 Arabidopsis thaliana 95-100 29940863-13 2018 Enhanced anthocyanin accumulation and reduced trichome production were related to the enhanced MYB75 and suppressed GL2 and some other differentially expressed genes associated with the TTG1/bHLH/MYB complexes. Anthocyanins 9-20 HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing protein Arabidopsis thaliana 116-119 29940863-13 2018 Enhanced anthocyanin accumulation and reduced trichome production were related to the enhanced MYB75 and suppressed GL2 and some other differentially expressed genes associated with the TTG1/bHLH/MYB complexes. Anthocyanins 9-20 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 186-190 29412900-7 2018 Moreover, electrospray ionization (ESI) and MS2/time-of-flight are currently the most popular instruments used for identification of anthocyanins; being positive mode of ESI the most widely used procedure for anthocyanin identification. Anthocyanins 133-145 MS2 Homo sapiens 44-47 29447963-0 2018 In vitro and in silico investigation of anthocyanin derivatives as soluble epoxide hydrolase inhibitors. Anthocyanins 40-51 epoxide hydrolase 2 Homo sapiens 67-92 29447963-2 2018 The inhibitory activity of anthocyanin derivatives toward soluble epoxide hydrolase (sEH) was tested for potential applications in the treatment of cardiovascular diseases. Anthocyanins 27-38 epoxide hydrolase 2 Homo sapiens 58-83 29447963-2 2018 The inhibitory activity of anthocyanin derivatives toward soluble epoxide hydrolase (sEH) was tested for potential applications in the treatment of cardiovascular diseases. Anthocyanins 27-38 epoxide hydrolase 2 Homo sapiens 85-88 29447963-3 2018 Anthocyanin derivatives 1-5 showed dose-dependent inhibitory activity toward sEH, with IC50 values ranging from 4.3+-0.2 to 25.3+-2.6muM. Anthocyanins 0-11 epoxide hydrolase 2 Homo sapiens 77-80 29447963-7 2018 Finally, anthocyanin derivatives (1-5) are potential inhibitors of sEH, and anthocyanin-rich fruits may be useful for the targeted treatment of cardiovascular diseases via sEH inhibition. Anthocyanins 9-20 epoxide hydrolase 2 Homo sapiens 67-70 29447963-7 2018 Finally, anthocyanin derivatives (1-5) are potential inhibitors of sEH, and anthocyanin-rich fruits may be useful for the targeted treatment of cardiovascular diseases via sEH inhibition. Anthocyanins 76-87 epoxide hydrolase 2 Homo sapiens 172-175 29587242-12 2018 In conclusion, the present study showed that treatment with ANT attenuated memory deficits, protected against oxidative damage in the brain, and restored AChE and ion pump activity in an STZ-induced SDAT in rats. Anthocyanins 60-63 acetylcholinesterase Rattus norvegicus 154-158 29669413-1 2018 All equilibrium and rate constants of heavenly blue anthocyanin (HBA 1) as well as the derivatives with two (HBA 2) or none (HBA 3) acylated units were determined. Anthocyanins 52-63 hemoglobin subunit alpha 1 Homo sapiens 65-70 29669413-3 2018 The sugars generate an efficient protective environment around position 2 (and 4) of the flavylium cation, through an intramolecular sandwich-type stacking that retards 35-fold the hydration reaction ( kh) and increases 8.8-fold the dehydration reaction ( k-h), when compared with the peonidin chromophore HBA 3. Anthocyanins 89-98 hemoglobin subunit alpha pseudogene 1 Homo sapiens 306-311 29502231-0 2018 Correction to: The heterologous expression of Arabidopsis PAP2 induces anthocyanin accumulation and inhibits plant growth in tomato. Anthocyanins 71-82 Purple acid phosphatases superfamily protein Arabidopsis thaliana 58-62 29699632-7 2018 In addition, activation of protein kinase B (Akt), mammalian target of rapamycin (mTOR), and ribosomal protein S6 (S6) were significantly suppressed by anthocyanin exposure. Anthocyanins 152-163 AKT serine/threonine kinase 1 Homo sapiens 45-48 29699632-7 2018 In addition, activation of protein kinase B (Akt), mammalian target of rapamycin (mTOR), and ribosomal protein S6 (S6) were significantly suppressed by anthocyanin exposure. Anthocyanins 152-163 mechanistic target of rapamycin kinase Homo sapiens 51-80 29699632-7 2018 In addition, activation of protein kinase B (Akt), mammalian target of rapamycin (mTOR), and ribosomal protein S6 (S6) were significantly suppressed by anthocyanin exposure. Anthocyanins 152-163 mechanistic target of rapamycin kinase Homo sapiens 82-86 29699632-7 2018 In addition, activation of protein kinase B (Akt), mammalian target of rapamycin (mTOR), and ribosomal protein S6 (S6) were significantly suppressed by anthocyanin exposure. Anthocyanins 152-163 ribosomal protein S6 Homo sapiens 93-113 28386931-7 2018 Indeed, functional studies demonstrated that AN2 is less able to induce anthocyanins than AN1, but nevertheless it has a strong ability to induce accumulation of hydroxycinnamic acid derivatives. Anthocyanins 72-84 AN2 Solanum tuberosum 45-48 29555784-8 2018 Furthermore, AtBBX21-expressing potato plants had reduced photoinhibition associated with higher production of anthocyanins and phenolic compounds, and higher expression of genes in the phenylpropanoid biosynthesis pathway. Anthocyanins 111-123 salt tolerance homolog2 Arabidopsis thaliana 13-20 29372433-2 2018 The Arabidopsis thaliana MYB90/PAP2 (production of anthocyanin pigment 2) was introduced into tomato to study its effect on anthocyanin accumulation. Anthocyanins 51-62 myb domain protein 90 Arabidopsis thaliana 25-30 29372433-2 2018 The Arabidopsis thaliana MYB90/PAP2 (production of anthocyanin pigment 2) was introduced into tomato to study its effect on anthocyanin accumulation. Anthocyanins 51-62 Purple acid phosphatases superfamily protein Arabidopsis thaliana 31-35 29372433-4 2018 The expression of anthocyanin biosynthetic genes and an anthocyanin-related basic helix-loop-helix (bHLH) gene SlAN1 was significantly increased in the transgenic line, suggesting that ectopic expression of AtPAP2 increases the expression of anthocyanin-related structural and regulatory genes to enhance anthocyanin content. Anthocyanins 18-29 Purple acid phosphatases superfamily protein Arabidopsis thaliana 207-213 29854843-2 2018 The aim of this study was to investigate the protective effects of cyanidin-3-glucoside (C3G), an important anthocyanin with great potential for preventing eye diseases, against 4-hydroxyhexenal- (HHE-) induced inflammatory damages in human retinal pigment epithelial cells, ARPE-19. Anthocyanins 108-119 Rap guanine nucleotide exchange factor 1 Homo sapiens 67-92 29562292-4 2018 In this study, two transcription factors were characterised as anthocyanin activators in purple pericarps: TaPpm1 (purple pericarp-MYB 1) and TaPpb1 (purple pericarp-bHLH 1). Anthocyanins 63-74 myb-related protein Hv1 Triticum aestivum 131-136 29774119-0 2018 Periostin, a signal transduction intermediate in TGF-beta-induced EMT in U-87MG human glioblastoma cells, and its inhibition by anthocyanidins. Anthocyanins 128-142 periostin Homo sapiens 0-9 29774119-5 2018 The effects of anthocyanidins, the most abundant diet-derived flavonoids, were examined on periostin-mediated downstream signaling pathways. Anthocyanins 15-29 periostin Homo sapiens 91-100 29774119-6 2018 Anthocyanidins were found to decrease periostin expression whether added under pre-, co- or post-treatment conditions along with TGF-beta, and altered the Akt and Fak signaling pathways. Anthocyanins 0-14 periostin Homo sapiens 38-47 29774119-6 2018 Anthocyanidins were found to decrease periostin expression whether added under pre-, co- or post-treatment conditions along with TGF-beta, and altered the Akt and Fak signaling pathways. Anthocyanins 0-14 transforming growth factor beta 1 Homo sapiens 129-137 29774119-6 2018 Anthocyanidins were found to decrease periostin expression whether added under pre-, co- or post-treatment conditions along with TGF-beta, and altered the Akt and Fak signaling pathways. Anthocyanins 0-14 AKT serine/threonine kinase 1 Homo sapiens 155-158 29774119-6 2018 Anthocyanidins were found to decrease periostin expression whether added under pre-, co- or post-treatment conditions along with TGF-beta, and altered the Akt and Fak signaling pathways. Anthocyanins 0-14 protein tyrosine kinase 2 Homo sapiens 163-166 29774119-8 2018 Taken together, our data demonstrate that periostin acts as a central element in TGF-beta-induced EMT, which can be prevented by diet-derived anthocyanidins. Anthocyanins 142-156 periostin Homo sapiens 42-51 29774119-8 2018 Taken together, our data demonstrate that periostin acts as a central element in TGF-beta-induced EMT, which can be prevented by diet-derived anthocyanidins. Anthocyanins 142-156 transforming growth factor beta 1 Homo sapiens 81-89 29548824-5 2018 pap1-1, a mutant defective in MYB75 (PAP1), a MYB-type transcription factor that positively regulates anthocyanin biosynthesis in Arabidopsis, was found to have significantly decreased survival rate to low N stress compared to its wild-type plants. Anthocyanins 102-113 purple acid phosphatase 11 Arabidopsis thaliana 0-6 29548824-5 2018 pap1-1, a mutant defective in MYB75 (PAP1), a MYB-type transcription factor that positively regulates anthocyanin biosynthesis in Arabidopsis, was found to have significantly decreased survival rate to low N stress compared to its wild-type plants. Anthocyanins 102-113 production of anthocyanin pigment 1 Arabidopsis thaliana 30-35 29548824-5 2018 pap1-1, a mutant defective in MYB75 (PAP1), a MYB-type transcription factor that positively regulates anthocyanin biosynthesis in Arabidopsis, was found to have significantly decreased survival rate to low N stress compared to its wild-type plants. Anthocyanins 102-113 phosphatidic acid phosphatase 1 Arabidopsis thaliana 37-41 29548824-6 2018 Similarly, tt3, a mutant with severe deficiency in dihydroflavonol 4-reductase (DFR), a key enzyme in anthocyanin biosynthesis, also showed much lower survival rate under low N stress. Anthocyanins 102-113 dihydroflavonol 4-reductase Arabidopsis thaliana 51-78 29548824-6 2018 Similarly, tt3, a mutant with severe deficiency in dihydroflavonol 4-reductase (DFR), a key enzyme in anthocyanin biosynthesis, also showed much lower survival rate under low N stress. Anthocyanins 102-113 dihydroflavonol 4-reductase Arabidopsis thaliana 80-83 29548824-8 2018 Furthermore, a metabolomics analysis using LC-MS revealed changes in flavonoid profile in the pap1-1 and tt3 plants, which established a causal relationship between plant adaptation to low N stress and these compounds including anthocyanins. Anthocyanins 228-240 purple acid phosphatase 11 Arabidopsis thaliana 94-100 29659549-0 2018 Blackcurrant Anthocyanins Increase the Levels of Collagen, Elastin, and Hyaluronic Acid in Human Skin Fibroblasts and Ovariectomized Rats. Anthocyanins 13-25 elastin Homo sapiens 59-66 29659549-6 2018 A quantitative RT-PCR analysis confirmed that BCE (1.0 or 10.0 mug/mL) and four types of anthocyanins (10 muM) altered the mRNA expression of ECM proteins and enzymes involved in ECM turnover. Anthocyanins 89-101 latexin Homo sapiens 106-109 29659549-7 2018 Immunofluorescence staining indicated that the anthocyanins stimulated the expression of ECM proteins, such as collagen (types I and III) and elastin. Anthocyanins 47-59 elastin Homo sapiens 142-149 29652826-0 2018 Cardiovascular Mechanisms of Action of Anthocyanins May Be Associated with the Impact of Microbial Metabolites on Heme Oxygenase-1 in Vascular Smooth Muscle Cells. Anthocyanins 39-51 heme oxygenase 1 Homo sapiens 114-130 29652826-2 2018 We aimed to explore the effects of microbial metabolites common to anthocyanins and other flavonoids on vascular smooth muscle heme oxygenase-1 (HO-1) expression. Anthocyanins 67-79 heme oxygenase 1 Homo sapiens 127-143 29652826-2 2018 We aimed to explore the effects of microbial metabolites common to anthocyanins and other flavonoids on vascular smooth muscle heme oxygenase-1 (HO-1) expression. Anthocyanins 67-79 heme oxygenase 1 Homo sapiens 145-149 29652826-5 2018 The present study demonstrates that phenolic metabolites of anthocyanins differentially affect HO-1 activity, often having additive, synergistic or nullifying effects. Anthocyanins 60-72 heme oxygenase 1 Homo sapiens 95-99 29641499-5 2018 The B-2 cultivar had the highest antioxidant potential than others because it contained the highest levels of polyphenols, especially anthocyanin, flavone, and phenolic acid; furthermore, this cultivar displayed anti-tumor effects against the human lung adenocarcinoma cell line A549, human hepatoma cell line Bel7402, human cancer colorectal adenoma cell line HCT-8, and HT-29 human colon cancer cell line. Anthocyanins 134-145 immunoglobulin kappa variable 5-2 Homo sapiens 4-7 29643453-5 2018 Genotyping by sequencing allowed the detection of eleven SNPs on two genes of the anthocyanin pathway, the flavanone 3-hydroxylase (F3H, EC: 1.14.11.9), and the leucoanthocyanidin dioxygenase (LDOX, EC 1.14.11.19; synonym anthocyanidin synthase, ANS) in twenty V. vinifera varieties. Anthocyanins 82-93 naringenin,2-oxoglutarate 3-dioxygenase Vitis vinifera 107-130 29643453-5 2018 Genotyping by sequencing allowed the detection of eleven SNPs on two genes of the anthocyanin pathway, the flavanone 3-hydroxylase (F3H, EC: 1.14.11.9), and the leucoanthocyanidin dioxygenase (LDOX, EC 1.14.11.19; synonym anthocyanidin synthase, ANS) in twenty V. vinifera varieties. Anthocyanins 82-93 naringenin,2-oxoglutarate 3-dioxygenase Vitis vinifera 132-135 29332168-6 2018 Knockout of F3H gene resulted in the discoloration of calli, validating the functional role of this gene in the anthocyanin biosynthesis in carrot as well as providing a visual marker for screening successfully edited events. Anthocyanins 112-123 flavanone 3-hydroxylase Arabidopsis thaliana 12-15 29487277-0 2018 AtMyb56 Regulates Anthocyanin Levels via the Modulation of AtGPT2 Expression in Response to Sucrose in Arabidopsis. Anthocyanins 18-29 myb domain protein 56 Arabidopsis thaliana 0-7 29487277-6 2018 Under normal conditions, anthocyanin accumulation was similar between Col-0 (wild type) and atmyb56 mutant seedlings; however, under sucrose treatment, the level of anthocyanin accumulation was lower in the atmyb56 mutant plants than in Col-0 plants. Anthocyanins 165-176 myb domain protein 56 Arabidopsis thaliana 207-214 29597321-0 2018 Ectopic Overexpression of a Novel R2R3-MYB, NtMYB2 from Chinese Narcissus Represses Anthocyanin Biosynthesis in Tobacco. Anthocyanins 84-95 uncharacterized protein LOC107775040 Nicotiana tabacum 39-42 29439209-7 2018 By contrast, BBX24 interferes with the binding of HY5 to the promoter of an anthocyanin biosynthetic gene, possibly by heterodimerizing with HY5 and preventing it from binding DNA. Anthocyanins 76-87 B-box zinc finger family protein Arabidopsis thaliana 13-18 29439209-7 2018 By contrast, BBX24 interferes with the binding of HY5 to the promoter of an anthocyanin biosynthetic gene, possibly by heterodimerizing with HY5 and preventing it from binding DNA. Anthocyanins 76-87 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 50-53 29439209-7 2018 By contrast, BBX24 interferes with the binding of HY5 to the promoter of an anthocyanin biosynthetic gene, possibly by heterodimerizing with HY5 and preventing it from binding DNA. Anthocyanins 76-87 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 141-144 29597321-4 2018 NtMYB2 belongs to subgroup 4 of the R2R3 MYB transcription factor family that are related to repressor MYBs involved in the regulation of anthocyanin and flavonoids. Anthocyanins 138-149 uncharacterized protein LOC107775040 Nicotiana tabacum 2-5 29597321-5 2018 Transient expression confirmed that NtMYB2 strongly reduced the red pigmentation induced by MYB- anthocyanin activators in agro-infiltrated tobacco leaves. Anthocyanins 97-108 uncharacterized protein LOC107775040 Nicotiana tabacum 38-41 29561841-9 2018 Furthermore, FIN219 level affected GUS-CCT1 seedling responses such as anthocyanin accumulation and bacterial resistance under various light conditions and MeJA treatment. Anthocyanins 71-82 Auxin-responsive GH3 family protein Arabidopsis thaliana 13-19 29587684-2 2018 In this study, we explored the biological activities of delphinidin, the most common of the anthocyanidin monomers, that were related to autophagy in HER-2 positive breast cancer MDA-MB-453 and BT474 cells. Anthocyanins 92-105 erb-b2 receptor tyrosine kinase 2 Homo sapiens 150-155 29146365-3 2018 The VIN wines had a low content of free anthocyanins and were high in vinyl-pyranoanthocyanins, and B-type vitisins. Anthocyanins 40-52 long intergenic non-protein coding RNA 1191 Homo sapiens 4-7 29146365-5 2018 Moreover VIN, especially at high dose, preserved non-anthocyanin phenolic compounds better than SO2. Anthocyanins 53-64 long intergenic non-protein coding RNA 1191 Homo sapiens 9-12 29561841-9 2018 Furthermore, FIN219 level affected GUS-CCT1 seedling responses such as anthocyanin accumulation and bacterial resistance under various light conditions and MeJA treatment. Anthocyanins 71-82 phosphorylcholine cytidylyltransferase Arabidopsis thaliana 39-43 29037704-6 2018 Anthocyanins exhibited tyrosine kinase inhibitory potential in silico and biochemically; cyanidin-3-O-glucoside had one of the highest binding affinities with all kinases, especially ABL1 (-8.5kcal/mol). Anthocyanins 0-12 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 183-187 29515203-7 2018 The most potent SIRT6 activator, cyanidin, belonged to anthocyanidins, and produced a 55-fold increase in SIRT6 activity compared to the 3-10 fold increase for the others. Anthocyanins 55-69 sirtuin 6 Homo sapiens 16-21 29332189-7 2018 Upon exposure to moderate high-light stress several of these genes are up-regulated to a lesser extent in ssrp1/spt16 compared to wild type plants, and accordingly the mutant plants accumulate lower amounts of anthocyanin pigments. Anthocyanins 210-221 high mobility group Arabidopsis thaliana 106-111 29328429-3 2018 In the present study, the regulation of apoptosis metabolism and antioxidative effects exhibited by anthocyanins [grape seed procyanidin (GSPE) and cyanidin-3-O-beta-glucoside chloride (C3G)] were investigated, and the molecular mechanism underlying this process was investigated in vivo and in vitro. Anthocyanins 100-112 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 186-189 29315644-9 2018 The MYB22 promoter can also be activated by the anthocyanin regulator, MYB10. Anthocyanins 48-59 LOW QUALITY PROTEIN: transcription factor MYB11 Malus domestica 4-9 29315644-9 2018 The MYB22 promoter can also be activated by the anthocyanin regulator, MYB10. Anthocyanins 48-59 transcription factor MYB113-like Malus domestica 71-76 29362083-0 2018 Functional characterization of a heterologously expressed Brassica napus WRKY41-1 transcription factor in regulating anthocyanin biosynthesis in Arabidopsis thaliana. Anthocyanins 117-128 WRKY family transcription factor Arabidopsis thaliana 73-79 29362083-2 2018 However, it is not known about the roles of AtWRKY41 from the model plant, Arabidopsis thaliana, and its ortholog, BnWRKY41, from the closely related and important oil-producing crop, Brassica napus, in the regulation of anthocyanin biosynthesis. Anthocyanins 221-232 probable WRKY transcription factor 4 Brassica napus 115-123 29362083-3 2018 Here, we found that the wrky41 mutation in A. thaliana resulted in a significant increase in anthocyanin levels in rosette leaves, indicating that AtWRKY41 acts as repressor of anthocyanin biosynthesis. Anthocyanins 93-104 WRKY family transcription factor Arabidopsis thaliana 24-30 29362083-3 2018 Here, we found that the wrky41 mutation in A. thaliana resulted in a significant increase in anthocyanin levels in rosette leaves, indicating that AtWRKY41 acts as repressor of anthocyanin biosynthesis. Anthocyanins 93-104 WRKY family transcription factor Arabidopsis thaliana 147-155 29362083-3 2018 Here, we found that the wrky41 mutation in A. thaliana resulted in a significant increase in anthocyanin levels in rosette leaves, indicating that AtWRKY41 acts as repressor of anthocyanin biosynthesis. Anthocyanins 177-188 WRKY family transcription factor Arabidopsis thaliana 24-30 29362083-3 2018 Here, we found that the wrky41 mutation in A. thaliana resulted in a significant increase in anthocyanin levels in rosette leaves, indicating that AtWRKY41 acts as repressor of anthocyanin biosynthesis. Anthocyanins 177-188 WRKY family transcription factor Arabidopsis thaliana 147-155 29362083-4 2018 RNA sequencing and quantitative real-time PCR analysis revealed increased expression of three regulatory genes AtMYB75, AtMYB111, and AtMYBD, and two structural genes, AT1G68440 and AtGSTF12, all of which contribute to anthocyanin biosynthesis, in the sixth rosette leaves of wrky41-2 plants at 20 days after germination. Anthocyanins 219-230 transmembrane protein Arabidopsis thaliana 168-177 29362083-4 2018 RNA sequencing and quantitative real-time PCR analysis revealed increased expression of three regulatory genes AtMYB75, AtMYB111, and AtMYBD, and two structural genes, AT1G68440 and AtGSTF12, all of which contribute to anthocyanin biosynthesis, in the sixth rosette leaves of wrky41-2 plants at 20 days after germination. Anthocyanins 219-230 glutathione S-transferase phi 12 Arabidopsis thaliana 182-190 29362083-6 2018 We further showed that overexpression of BnWRKY41-1 in the A. thaliana wrky41-2 mutant rescued the higher anthocyanin content phenotype in rosette leaves of the mutant. Anthocyanins 106-117 probable WRKY transcription factor 4 Brassica napus 41-49 29362083-6 2018 We further showed that overexpression of BnWRKY41-1 in the A. thaliana wrky41-2 mutant rescued the higher anthocyanin content phenotype in rosette leaves of the mutant. Anthocyanins 106-117 WRKY family transcription factor Arabidopsis thaliana 71-77 29362083-7 2018 Moreover, the elevated expression levels in wrky41-2 rosette leaves of several important regulatory and structural genes regulating anthocyanin biosynthesis were not observed in the BnWRKY41-1 overexpressing lines. Anthocyanins 132-143 WRKY family transcription factor Arabidopsis thaliana 44-50 29362083-7 2018 Moreover, the elevated expression levels in wrky41-2 rosette leaves of several important regulatory and structural genes regulating anthocyanin biosynthesis were not observed in the BnWRKY41-1 overexpressing lines. Anthocyanins 132-143 probable WRKY transcription factor 4 Brassica napus 182-190 29362083-8 2018 These results reveal that BnWRKY41-1 has a similar role with AtWRKY41 in regulating anthocyanin biosynthesis when overexpressed in A. thaliana. Anthocyanins 84-95 probable WRKY transcription factor 4 Brassica napus 26-34 29362083-8 2018 These results reveal that BnWRKY41-1 has a similar role with AtWRKY41 in regulating anthocyanin biosynthesis when overexpressed in A. thaliana. Anthocyanins 84-95 WRKY family transcription factor Arabidopsis thaliana 61-69 29541082-13 2018 Quantitative real time PCR revealed that the loss of anthocyanin in transgenic flowers overexpressed MrANR or MrLAR is probably attributed to decreased expression of tobacco chalcone isomerase (CHI) gene. Anthocyanins 53-64 chalcone--flavanone isomerase Nicotiana tabacum 174-192 29541082-13 2018 Quantitative real time PCR revealed that the loss of anthocyanin in transgenic flowers overexpressed MrANR or MrLAR is probably attributed to decreased expression of tobacco chalcone isomerase (CHI) gene. Anthocyanins 53-64 chalcone--flavanone isomerase Nicotiana tabacum 194-197 29520290-12 2018 While HSFA4A overexpression was associated with better growth, higher chlorophyll and lower anthocyanin content in saline conditions, the knockout hsfa4a mutant showed hypersensitivity to various stresses. Anthocyanins 92-103 heat shock transcription factor A4A Arabidopsis thaliana 6-12 29393642-5 2018 In addition, the anthocyanins decreased vascular-endothelial-cell-growth-factor levels and activated Akt-signal pathways. Anthocyanins 17-29 AKT serine/threonine kinase 1 Homo sapiens 101-104 29332189-7 2018 Upon exposure to moderate high-light stress several of these genes are up-regulated to a lesser extent in ssrp1/spt16 compared to wild type plants, and accordingly the mutant plants accumulate lower amounts of anthocyanin pigments. Anthocyanins 210-221 global transcription factor C Arabidopsis thaliana 112-117 29030260-1 2018 Cyanidin-3-O-glucoside (C3G) is an anthocyanin that has been reported to reduce the toxicity of heavy metals. Anthocyanins 35-46 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 24-27 28718016-0 2018 Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells. Anthocyanins 13-25 low density lipoprotein receptor Homo sapiens 97-109 28718016-9 2018 LDLR protein levels were markedly increased by anthocyanin-rich fraction, but not by anthocyanin-free fraction. Anthocyanins 47-58 low density lipoprotein receptor Homo sapiens 0-4 28718016-10 2018 CONCLUSION: mTORC1-dependent post-transcriptional induction of LDLR by BCE anthocyanins drove the transport of LDL-derived cholesterol to the apical side of the enterocytes. Anthocyanins 75-87 CREB regulated transcription coactivator 1 Mus musculus 12-18 28718016-10 2018 CONCLUSION: mTORC1-dependent post-transcriptional induction of LDLR by BCE anthocyanins drove the transport of LDL-derived cholesterol to the apical side of the enterocytes. Anthocyanins 75-87 low density lipoprotein receptor Homo sapiens 63-67 29382057-1 2018 Cyanidin-3-O-glucoside (C3G), the predominant anthocyanin in haskap berries (Lonicera caerulea L.), possesses antioxidant and many other biological activities. Anthocyanins 46-57 Rap guanine nucleotide exchange factor 1 Homo sapiens 24-27 29232522-5 2018 Anthocyanin biosynthesis is controlled by members of three different transcription factor (TF) families, such as MYB, basic helix-loop-helix (bHLH), and WD40 repeats (WDR), which function as a MBW complex. Anthocyanins 0-11 transcription factor MYB28-like Brassica oleracea 113-116 29232522-6 2018 We identified three MYB, six bHLH, and one WDR TFs that regulate anthocyanin biosynthesis in ornamental cabbage. Anthocyanins 65-76 transcription factor MYB28-like Brassica oleracea 20-23 29232522-9 2018 Among the regulatory genes, BoPAP2 (MYB), BoTT8, BoEGL3.1, and BoMYC1.2 (bHLH), and BoTTG1 (WDR) were identified as candidates for the regulation of anthocyanin biosynthesis. Anthocyanins 149-160 transcription factor MYB28-like Brassica oleracea 36-39 29232522-9 2018 Among the regulatory genes, BoPAP2 (MYB), BoTT8, BoEGL3.1, and BoMYC1.2 (bHLH), and BoTTG1 (WDR) were identified as candidates for the regulation of anthocyanin biosynthesis. Anthocyanins 149-160 transcription factor TT8 Brassica oleracea 42-47 29232522-9 2018 Among the regulatory genes, BoPAP2 (MYB), BoTT8, BoEGL3.1, and BoMYC1.2 (bHLH), and BoTTG1 (WDR) were identified as candidates for the regulation of anthocyanin biosynthesis. Anthocyanins 149-160 protein TRANSPARENT TESTA GLABRA 1 Brassica oleracea 84-90 29316620-6 2018 Other phytochemicals such as curcumin, resveratrol, and anthocyanins also inhibit COX2. Anthocyanins 56-68 mitochondrially encoded cytochrome c oxidase II Homo sapiens 82-86 29521054-8 2018 Another mechanism that might explain the lower glucose level in the blood after a meal with anthocyanins compared to a meal without them is the inhibition of intestinal alpha-glucosidase and pancreatic alpha-amylase by these compounds. Anthocyanins 92-104 amylase alpha 2A Homo sapiens 191-215 28940939-1 2018 Previous studies have shown that GLABRA3 (AtGL3), a bHLH transcription factor, plays essential roles in anthocyanin biosynthesis and trichome formation in Arabidopsis thaliana. Anthocyanins 104-115 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 33-40 29521054-3 2018 In rodent studies and in studies with isolated omental adipocytes, it was observed that anthocyanins regulated the carbohydrate metabolism in the body due to the upregulation of GLUT4 (insulinregulated glucose transporter) translocation, increased activation of PPARgamma (peroxisome proliferator-activated receptor-gamma) in adipose tissue and skeletal muscles as well as increased secretion of adiponectin and leptin. Anthocyanins 88-100 solute carrier family 2 member 4 Homo sapiens 178-183 29521054-3 2018 In rodent studies and in studies with isolated omental adipocytes, it was observed that anthocyanins regulated the carbohydrate metabolism in the body due to the upregulation of GLUT4 (insulinregulated glucose transporter) translocation, increased activation of PPARgamma (peroxisome proliferator-activated receptor-gamma) in adipose tissue and skeletal muscles as well as increased secretion of adiponectin and leptin. Anthocyanins 88-100 peroxisome proliferator activated receptor gamma Homo sapiens 262-271 29521054-3 2018 In rodent studies and in studies with isolated omental adipocytes, it was observed that anthocyanins regulated the carbohydrate metabolism in the body due to the upregulation of GLUT4 (insulinregulated glucose transporter) translocation, increased activation of PPARgamma (peroxisome proliferator-activated receptor-gamma) in adipose tissue and skeletal muscles as well as increased secretion of adiponectin and leptin. Anthocyanins 88-100 peroxisome proliferator activated receptor gamma Homo sapiens 273-321 29521054-3 2018 In rodent studies and in studies with isolated omental adipocytes, it was observed that anthocyanins regulated the carbohydrate metabolism in the body due to the upregulation of GLUT4 (insulinregulated glucose transporter) translocation, increased activation of PPARgamma (peroxisome proliferator-activated receptor-gamma) in adipose tissue and skeletal muscles as well as increased secretion of adiponectin and leptin. Anthocyanins 88-100 adiponectin, C1Q and collagen domain containing Homo sapiens 396-407 28940939-1 2018 Previous studies have shown that GLABRA3 (AtGL3), a bHLH transcription factor, plays essential roles in anthocyanin biosynthesis and trichome formation in Arabidopsis thaliana. Anthocyanins 104-115 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 42-47 28940939-5 2018 Ectopic expression of the BnGL3-1 gene in the A. thaliana gl3-3 mutant resulted in levels of anthocyanins and numbers of trichomes in true leaves that were higher than in wild-type plants. Anthocyanins 93-105 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 58-61 28940939-6 2018 Moreover, overexpression of BnGL3-1 in gl3-3 compensated for the promotion and repression of genes involved in anthocyanin biosynthesis and trichome formation, respectively, that has been reported in gl3-3 young shoots and expanding true leaves. Anthocyanins 111-122 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 39-42 28940939-6 2018 Moreover, overexpression of BnGL3-1 in gl3-3 compensated for the promotion and repression of genes involved in anthocyanin biosynthesis and trichome formation, respectively, that has been reported in gl3-3 young shoots and expanding true leaves. Anthocyanins 111-122 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 200-203 28940939-7 2018 This study provides new insights into GL3 function in anthocyanin biosynthesis and trichome formation in crucifers, and represents a promising target for genetic manipulation of B. napus. Anthocyanins 54-65 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 38-41 30273518-3 2018 Elevated anthocyanin levels are observed in mkk6 knock out mutant plants. Anthocyanins 9-20 MAP kinase kinase 6 Arabidopsis thaliana 44-48 29944442-0 2018 Effect of phosphate deficiency-induced anthocyanin accumulation on the expression of Solanum lycopersicum GLABRA3 (SlGL3) in tomato. Anthocyanins 39-50 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 106-113 29944442-1 2018 In Arabidopsis thaliana, the bHLH transcription factor, GLABRA3 (AtGL3), is an important regulator of epidermal cell differentiation and positively controls anthocyanin accumulation. Anthocyanins 157-168 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 56-63 29944442-1 2018 In Arabidopsis thaliana, the bHLH transcription factor, GLABRA3 (AtGL3), is an important regulator of epidermal cell differentiation and positively controls anthocyanin accumulation. Anthocyanins 157-168 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 65-70 29944442-2 2018 In contrast, we previously showed that Solanum lycopersicum GLABRA3 (SlGL3), the AtGL3 homolog, suppressed anthocyanin accumulation in Arabidopsis. Anthocyanins 107-118 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 60-67 29944442-2 2018 In contrast, we previously showed that Solanum lycopersicum GLABRA3 (SlGL3), the AtGL3 homolog, suppressed anthocyanin accumulation in Arabidopsis. Anthocyanins 107-118 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 81-86 31275041-6 2018 In this study, using an Arabidopsis mutant with mutation in two ETHYLENE RESPONSE FACTOR (ERF) genes, AtERF4 and AtERF8, we investigated the regulatory signaling pathway that leads to the production of anthocyanin in response to light. Anthocyanins 202-213 ethylene responsive element binding factor 4 Arabidopsis thaliana 102-108 30273518-4 2018 RNA-sequencing analysis revealed that the expression level of MYB75 (Myb transcription factor 75), which encodes a key positive regulator of anthocyanin biosynthesis, is up-regulated in mkk6 mutant plants, suggesting that increased MYB75 expression contributes to the elevated anthocyanin levels. Anthocyanins 141-152 production of anthocyanin pigment 1 Arabidopsis thaliana 62-67 31275041-6 2018 In this study, using an Arabidopsis mutant with mutation in two ETHYLENE RESPONSE FACTOR (ERF) genes, AtERF4 and AtERF8, we investigated the regulatory signaling pathway that leads to the production of anthocyanin in response to light. Anthocyanins 202-213 ethylene response factor 8 Arabidopsis thaliana 113-119 30273518-4 2018 RNA-sequencing analysis revealed that the expression level of MYB75 (Myb transcription factor 75), which encodes a key positive regulator of anthocyanin biosynthesis, is up-regulated in mkk6 mutant plants, suggesting that increased MYB75 expression contributes to the elevated anthocyanin levels. Anthocyanins 141-152 MAP kinase kinase 6 Arabidopsis thaliana 186-190 30273518-4 2018 RNA-sequencing analysis revealed that the expression level of MYB75 (Myb transcription factor 75), which encodes a key positive regulator of anthocyanin biosynthesis, is up-regulated in mkk6 mutant plants, suggesting that increased MYB75 expression contributes to the elevated anthocyanin levels. Anthocyanins 277-288 production of anthocyanin pigment 1 Arabidopsis thaliana 62-67 30273518-4 2018 RNA-sequencing analysis revealed that the expression level of MYB75 (Myb transcription factor 75), which encodes a key positive regulator of anthocyanin biosynthesis, is up-regulated in mkk6 mutant plants, suggesting that increased MYB75 expression contributes to the elevated anthocyanin levels. Anthocyanins 277-288 MAP kinase kinase 6 Arabidopsis thaliana 186-190 30273518-4 2018 RNA-sequencing analysis revealed that the expression level of MYB75 (Myb transcription factor 75), which encodes a key positive regulator of anthocyanin biosynthesis, is up-regulated in mkk6 mutant plants, suggesting that increased MYB75 expression contributes to the elevated anthocyanin levels. Anthocyanins 277-288 production of anthocyanin pigment 1 Arabidopsis thaliana 232-237 30273518-5 2018 In addition, suppression of high sucrose-induced anthocyanin production by pathogen associated molecular pattern-triggered immunity is also dependent on MKK6, further supporting that MKK6 is a key negative regulator of anthocyanin biosynthesis in Arabidopsis. Anthocyanins 49-60 MAP kinase kinase 6 Arabidopsis thaliana 183-187 30273518-5 2018 In addition, suppression of high sucrose-induced anthocyanin production by pathogen associated molecular pattern-triggered immunity is also dependent on MKK6, further supporting that MKK6 is a key negative regulator of anthocyanin biosynthesis in Arabidopsis. Anthocyanins 219-230 MAP kinase kinase 6 Arabidopsis thaliana 183-187 29068672-2 2017 Previously we reported that an anthocyanin-enriched black raspberry extract (BE) enhanced repair of dibenzo-[a,l]-pyrene dihydrodiol (DBP-diol)-induced DNA adducts and inhibited DBP-diol and DBP-diolepoxide (DBPDE)-induced mutagenesis in a lacI rat oral fibroblast cell line, suggesting a role for BRB in the inhibition of initiation of carcinogenesis. Anthocyanins 31-42 D-box binding PAR bZIP transcription factor Rattus norvegicus 134-137 29286333-0 2017 Phytoestrogenic Activity of Blackcurrant Anthocyanins Is Partially Mediated through Estrogen Receptor Beta. Anthocyanins 41-53 estrogen receptor 2 Homo sapiens 84-106 29286333-3 2017 In this study, we investigated the participation of ERbeta in the phytoestrogen activity of these anthocyanins. Anthocyanins 98-110 estrogen receptor 2 Homo sapiens 52-58 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 13-24 estrogen receptor 2 Homo sapiens 33-39 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 13-24 estrogen receptor 2 Homo sapiens 91-97 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 13-24 estrogen receptor 2 Homo sapiens 91-97 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 159-171 estrogen receptor 2 Homo sapiens 33-39 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 159-171 estrogen receptor 2 Homo sapiens 91-97 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 159-171 estrogen receptor 1 Homo sapiens 121-128 29286333-4 2017 Blackcurrant anthocyanin induced ERbeta-mediated transcriptional activity, and the IC50 of ERbeta was lower than that of ERalpha, indicating that blackcurrant anthocyanins have a higher binding affinity to ERbeta. Anthocyanins 159-171 estrogen receptor 2 Homo sapiens 91-97 29286333-9 2017 These results show that blackcurrant anthocyanins exert phytoestrogen activity via ERbeta. Anthocyanins 37-49 estrogen receptor 2 Homo sapiens 83-89 28856781-0 2017 Cellular apoptosis and cardiac dysfunction in STZ-induced diabetic rats attenuated by anthocyanins via activation of IGFI-R/PI3K/Akt survival signaling. Anthocyanins 86-98 AKT serine/threonine kinase 1 Rattus norvegicus 129-132 29186488-6 2017 The other candidate R3 MYB and R2R3 MYB repressors of anthocyanin biosynthesis were also identified in tomato via a genome-wide search. Anthocyanins 54-65 transcription factor MYB117 Solanum lycopersicum 31-39 29039492-0 2017 Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling. Anthocyanins 19-31 erb-b2 receptor tyrosine kinase 2 Homo sapiens 40-45 29039492-0 2017 Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling. Anthocyanins 19-31 protein tyrosine kinase 2 Homo sapiens 147-150 29039492-1 2017 This study aimed to investigate the role of focal adhesion kinase (FAK) signaling in the inhibitory effects of black rice anthocyanins (BRACs) on human epidermal growth factor receptor-2 (HER-2)-positive human breast cancer cell metastasis, using the MCF-10A, MCF-7 and MDA-MB-453 cells. Anthocyanins 122-134 protein tyrosine kinase 2 Homo sapiens 67-70 29039492-1 2017 This study aimed to investigate the role of focal adhesion kinase (FAK) signaling in the inhibitory effects of black rice anthocyanins (BRACs) on human epidermal growth factor receptor-2 (HER-2)-positive human breast cancer cell metastasis, using the MCF-10A, MCF-7 and MDA-MB-453 cells. Anthocyanins 122-134 erb-b2 receptor tyrosine kinase 2 Homo sapiens 146-186 29039492-1 2017 This study aimed to investigate the role of focal adhesion kinase (FAK) signaling in the inhibitory effects of black rice anthocyanins (BRACs) on human epidermal growth factor receptor-2 (HER-2)-positive human breast cancer cell metastasis, using the MCF-10A, MCF-7 and MDA-MB-453 cells. Anthocyanins 122-134 erb-b2 receptor tyrosine kinase 2 Homo sapiens 188-193 28961464-6 2017 Consistent with this, the relative expression levels of anthocyanin-synthesis-related genes, including DFR, LDOX, MybA1 and UFGT, in VA-treated cell cultures were much higher than those in control, and high total anthocyanin accumulation was noted in the VA-treated cell cultures as well. Anthocyanins 56-67 dihydroflavonol 4-reductase Vitis vinifera 103-106 29068672-2 2017 Previously we reported that an anthocyanin-enriched black raspberry extract (BE) enhanced repair of dibenzo-[a,l]-pyrene dihydrodiol (DBP-diol)-induced DNA adducts and inhibited DBP-diol and DBP-diolepoxide (DBPDE)-induced mutagenesis in a lacI rat oral fibroblast cell line, suggesting a role for BRB in the inhibition of initiation of carcinogenesis. Anthocyanins 31-42 D-box binding PAR bZIP transcription factor Rattus norvegicus 178-181 29068672-2 2017 Previously we reported that an anthocyanin-enriched black raspberry extract (BE) enhanced repair of dibenzo-[a,l]-pyrene dihydrodiol (DBP-diol)-induced DNA adducts and inhibited DBP-diol and DBP-diolepoxide (DBPDE)-induced mutagenesis in a lacI rat oral fibroblast cell line, suggesting a role for BRB in the inhibition of initiation of carcinogenesis. Anthocyanins 31-42 D-box binding PAR bZIP transcription factor Rattus norvegicus 178-181 28961464-6 2017 Consistent with this, the relative expression levels of anthocyanin-synthesis-related genes, including DFR, LDOX, MybA1 and UFGT, in VA-treated cell cultures were much higher than those in control, and high total anthocyanin accumulation was noted in the VA-treated cell cultures as well. Anthocyanins 56-67 leucoanthocyanidin dioxygenase Vitis vinifera 108-112 28867321-3 2017 Several studies have indicated chemopreventive and chemotherapeutic activity of cyanidin-3-glucoside (C3G) as an anthocyanin component. Anthocyanins 113-124 Rap guanine nucleotide exchange factor 1 Homo sapiens 80-105 29075987-7 2017 Anthocyanins also maintained the stability of the redox system (GSH-PX, T-SOD and MDA) in plasma and liver structures (p < 0.001) and reduced the levels of inflammatory factors (IL-1, IL-6 and TNF-alpha) in the liver (p < 0.05). Anthocyanins 0-12 interleukin 1 complex Mus musculus 181-185 29075987-7 2017 Anthocyanins also maintained the stability of the redox system (GSH-PX, T-SOD and MDA) in plasma and liver structures (p < 0.001) and reduced the levels of inflammatory factors (IL-1, IL-6 and TNF-alpha) in the liver (p < 0.05). Anthocyanins 0-12 interleukin 6 Mus musculus 187-191 29075987-7 2017 Anthocyanins also maintained the stability of the redox system (GSH-PX, T-SOD and MDA) in plasma and liver structures (p < 0.001) and reduced the levels of inflammatory factors (IL-1, IL-6 and TNF-alpha) in the liver (p < 0.05). Anthocyanins 0-12 tumor necrosis factor Mus musculus 196-205 28691397-3 2017 Cyanidin-3-glucoside (C3G) is an anthocyanin compound that occurs naturally in many fruits and vegetables. Anthocyanins 33-44 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 0-25 29131815-7 2017 In addition, kai2 plants have reduced anthocyanin biosynthesis during drought, and are hyposensitive to abscisic acid (ABA) in stomatal closure and cotyledon opening assays. Anthocyanins 38-49 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 13-17 28901377-11 2017 The results suggested that blackcurrant anthocyanins may act as cell arrest and death inducers via KDM5B downregulation in healthy breast cells. Anthocyanins 40-52 lysine demethylase 5B Homo sapiens 99-104 28736294-0 2017 Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Abeta1-42-induced neuroinflammation and neurodegeneration via the NF-KB /JNK/GSK3beta signaling pathway. Anthocyanins 28-39 mitogen-activated protein kinase 8 Mus musculus 151-154 28736294-0 2017 Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Abeta1-42-induced neuroinflammation and neurodegeneration via the NF-KB /JNK/GSK3beta signaling pathway. Anthocyanins 28-39 glycogen synthase kinase 3 alpha Mus musculus 155-163 28736294-4 2017 We determined that anthocyanins alone or conjugated with PEG-AuNPs (AnPEG-AuNPs) reduced Abeta1-42-induced neuroinflammatory and neuroapoptotic markers via inhibiting the p-JNK/NF-kappaB/p-GSK3beta pathway in both in vivo and in vitro AD models. Anthocyanins 19-31 mitogen-activated protein kinase 8 Mus musculus 173-176 28736294-4 2017 We determined that anthocyanins alone or conjugated with PEG-AuNPs (AnPEG-AuNPs) reduced Abeta1-42-induced neuroinflammatory and neuroapoptotic markers via inhibiting the p-JNK/NF-kappaB/p-GSK3beta pathway in both in vivo and in vitro AD models. Anthocyanins 19-31 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 177-186 28736294-4 2017 We determined that anthocyanins alone or conjugated with PEG-AuNPs (AnPEG-AuNPs) reduced Abeta1-42-induced neuroinflammatory and neuroapoptotic markers via inhibiting the p-JNK/NF-kappaB/p-GSK3beta pathway in both in vivo and in vitro AD models. Anthocyanins 19-31 glycogen synthase kinase 3 alpha Mus musculus 189-197 28919902-9 2017 Further, transient color assays reveal that AcMYBF110 can autonomously induce anthocyanin accumulation in Nicotiana tabacum leaves by activating the transcription of dihydroflavonol 4-reductase (NtDFR), anthocyanidin synthase (NtANS) and NtUFGT. Anthocyanins 78-89 dihydroflavonol-4-reductase Nicotiana tabacum 166-193 29163590-1 2017 In apple, the MYB transcription factor MYB10 controls the accumulation of anthocyanins. Anthocyanins 74-86 transcription factor MYB113-like Malus domestica 39-44 29163590-3 2017 In some apple accessions a natural mutation, termed R6, has more copies of this motif within the MYB10 promoter resulting in stronger auto-activation and elevated anthocyanins. Anthocyanins 163-175 transcription factor MYB113-like Malus domestica 97-102 29163590-7 2017 Insertion of the apple R6 motif into orthologous promoters of MYB10 in pear (PcMYB10) and Arabidopsis (AtMY75) elevated anthocyanin levels. Anthocyanins 120-131 transcription factor MYB113-like Malus domestica 62-67 28994705-9 2017 Subgroup analyses suggested that purified anthocyanins were more effective at improving glycemic control, insulin sensitivity, and lipids among patients with elevated metabolic markers. Anthocyanins 42-54 insulin Homo sapiens 106-113 29104579-0 2017 High Ambient Temperature Represses Anthocyanin Biosynthesis through Degradation of HY5. Anthocyanins 35-46 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 83-86 29104579-6 2017 Here, we show that high ambient temperatures repress anthocyanin biosynthesis through the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) and the positive regulator of anthocyanin biosynthesis ELONGATED HYPOCOTYL5 (HY5). Anthocyanins 53-64 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 142-146 29104579-6 2017 Here, we show that high ambient temperatures repress anthocyanin biosynthesis through the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) and the positive regulator of anthocyanin biosynthesis ELONGATED HYPOCOTYL5 (HY5). Anthocyanins 53-64 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 213-223 29104579-6 2017 Here, we show that high ambient temperatures repress anthocyanin biosynthesis through the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) and the positive regulator of anthocyanin biosynthesis ELONGATED HYPOCOTYL5 (HY5). Anthocyanins 53-64 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 225-228 29104579-6 2017 Here, we show that high ambient temperatures repress anthocyanin biosynthesis through the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) and the positive regulator of anthocyanin biosynthesis ELONGATED HYPOCOTYL5 (HY5). Anthocyanins 178-189 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 142-146 29104579-6 2017 Here, we show that high ambient temperatures repress anthocyanin biosynthesis through the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) and the positive regulator of anthocyanin biosynthesis ELONGATED HYPOCOTYL5 (HY5). Anthocyanins 178-189 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 213-223 29104579-6 2017 Here, we show that high ambient temperatures repress anthocyanin biosynthesis through the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) and the positive regulator of anthocyanin biosynthesis ELONGATED HYPOCOTYL5 (HY5). Anthocyanins 178-189 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 225-228 29104579-11 2017 The degradation of HY5 derepresses the expression of MYBL2, which partially mediates the high temperature repression of anthocyanin biosynthesis. Anthocyanins 120-131 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 19-22 29104579-11 2017 The degradation of HY5 derepresses the expression of MYBL2, which partially mediates the high temperature repression of anthocyanin biosynthesis. Anthocyanins 120-131 MYB-like 2 Arabidopsis thaliana 53-58 29104579-12 2017 Overall, our study demonstrates that high ambient temperatures repress anthocyanin biosynthesis through a COP1-HY5 signaling module. Anthocyanins 71-82 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 106-110 29104579-12 2017 Overall, our study demonstrates that high ambient temperatures repress anthocyanin biosynthesis through a COP1-HY5 signaling module. Anthocyanins 71-82 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 111-114 29104582-5 2017 Further experiments elucidated that VvVHP1; 2 overexpression up-regulated the expression of the genes related to anthocyanin biosynthesis and transport via hexokinase-mediated glucose signal and thereby promoted anthocyanin accumulation in berry skins and Arabidopsis leaves. Anthocyanins 113-124 hexokinase Arabidopsis thaliana 156-166 27730512-6 2017 Interestingly, the anthocyanin-loaded PEG-AuNPs also regulated the p-PI3K/p-Akt/p-GSK3beta pathway and, as a result, prevented the hyperphosphorylation of tau protein at serines 413 and 404 in the Abeta1-42-injected mice. Anthocyanins 19-30 thymoma viral proto-oncogene 1 Mus musculus 76-79 27730512-6 2017 Interestingly, the anthocyanin-loaded PEG-AuNPs also regulated the p-PI3K/p-Akt/p-GSK3beta pathway and, as a result, prevented the hyperphosphorylation of tau protein at serines 413 and 404 in the Abeta1-42-injected mice. Anthocyanins 19-30 glycogen synthase kinase 3 alpha Mus musculus 82-90 27730512-7 2017 Western blot results of cytochrome c, Bax/Bcl2, caspases and poly (ADP-ribose) polymerase-1 expression levels, and immunohistochemical Nissl and Fluoro-Jade B staining also indicated that the anthocyanin-loaded PEG-AuNPs inhibited apoptosis and neurodegeneration in the Abeta1-42-injected mice. Anthocyanins 192-203 poly (ADP-ribose) polymerase family, member 1 Mus musculus 61-91 28691370-7 2017 Subsequent experiment using an inflamed Caco-2 BBe1/THP-1 co-culture cell model showed these transported anthocyanins inhibited IL-8 and TNF-alpha secretion,and expression of pro-inflammatory cytokines by blocking NF-kappaB, and MAPK mediated inflammatory cellular signaling cascades, but with varying degrees due to structural features. Anthocyanins 105-117 GLI family zinc finger 2 Homo sapiens 52-57 28691370-7 2017 Subsequent experiment using an inflamed Caco-2 BBe1/THP-1 co-culture cell model showed these transported anthocyanins inhibited IL-8 and TNF-alpha secretion,and expression of pro-inflammatory cytokines by blocking NF-kappaB, and MAPK mediated inflammatory cellular signaling cascades, but with varying degrees due to structural features. Anthocyanins 105-117 C-X-C motif chemokine ligand 8 Homo sapiens 128-132 28691370-7 2017 Subsequent experiment using an inflamed Caco-2 BBe1/THP-1 co-culture cell model showed these transported anthocyanins inhibited IL-8 and TNF-alpha secretion,and expression of pro-inflammatory cytokines by blocking NF-kappaB, and MAPK mediated inflammatory cellular signaling cascades, but with varying degrees due to structural features. Anthocyanins 105-117 tumor necrosis factor Homo sapiens 137-146 28959020-3 2017 The regulatory gene PAP1 (production of anthocyanin pigment 1) from Arabidopsis is reported to increase initial flavonoid flux and anthocyanin content. Anthocyanins 40-51 production of anthocyanin pigment 1 Arabidopsis thaliana 20-24 28901892-4 2017 ACN supplementation reduced monocyte-platelet aggregate formation by 39 %; inhibited platelet endothelial cell adhesion molecule-1 expression by 14 %; reduced platelet activation-dependant conformational change and degranulation by reducing procaspase activating compound-1 (PAC-1) ( 10 %) and P-selectin expression ( 14 %), respectively; and reduced ADP-induced whole blood platelet aggregation by 29 %. Anthocyanins 0-3 ADCYAP receptor type I Homo sapiens 241-273 28901892-4 2017 ACN supplementation reduced monocyte-platelet aggregate formation by 39 %; inhibited platelet endothelial cell adhesion molecule-1 expression by 14 %; reduced platelet activation-dependant conformational change and degranulation by reducing procaspase activating compound-1 (PAC-1) ( 10 %) and P-selectin expression ( 14 %), respectively; and reduced ADP-induced whole blood platelet aggregation by 29 %. Anthocyanins 0-3 ADCYAP receptor type I Homo sapiens 275-280 28901892-4 2017 ACN supplementation reduced monocyte-platelet aggregate formation by 39 %; inhibited platelet endothelial cell adhesion molecule-1 expression by 14 %; reduced platelet activation-dependant conformational change and degranulation by reducing procaspase activating compound-1 (PAC-1) ( 10 %) and P-selectin expression ( 14 %), respectively; and reduced ADP-induced whole blood platelet aggregation by 29 %. Anthocyanins 0-3 selectin P Homo sapiens 294-304 28919902-9 2017 Further, transient color assays reveal that AcMYBF110 can autonomously induce anthocyanin accumulation in Nicotiana tabacum leaves by activating the transcription of dihydroflavonol 4-reductase (NtDFR), anthocyanidin synthase (NtANS) and NtUFGT. Anthocyanins 78-89 dihydroflavonol-4-reductase Nicotiana tabacum 195-200 28393456-0 2017 Blackcurrant anthocyanins modulate CCL11 secretion and suppress allergic airway inflammation. Anthocyanins 13-25 C-C motif chemokine ligand 11 Homo sapiens 35-40 28317281-6 2017 In other mechanisms involved, the polyphenols except anthocyanins strongly prevented or reversed the effect on mitochondrial content/biogenesis, increased expression of manganese superoxide dismutase, and prevented the large increase in TNF-alpha expression. Anthocyanins 53-65 tumor necrosis factor Homo sapiens 237-246 28393456-5 2017 Ten milligram per kilogram (total anthocyanins) of a commercially available, anthocyanin-rich New Zealand "Ben Ard" blackcurrant extract ("Currantex 30") attenuated ovalbumin-induced inflammation, eosinophilia (by 52.45 +- 38.50%), and CCL11 production (by 48.55 +- 28.56%) in a mouse model of acute allergic lung inflammation. Anthocyanins 34-46 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 165-174 28393456-5 2017 Ten milligram per kilogram (total anthocyanins) of a commercially available, anthocyanin-rich New Zealand "Ben Ard" blackcurrant extract ("Currantex 30") attenuated ovalbumin-induced inflammation, eosinophilia (by 52.45 +- 38.50%), and CCL11 production (by 48.55 +- 28.56%) in a mouse model of acute allergic lung inflammation. Anthocyanins 34-45 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 165-174 28393456-7 2017 Correlation analysis identified potential blackcurrant polyphenolic anthocyanin constituents specifically delphinidins and cyanidins, involved in CCL11 suppression. Anthocyanins 68-79 C-C motif chemokine ligand 11 Homo sapiens 146-151 28384410-6 2017 Each of the 3 major anthocyanins found in lingonberry (cyanidin-3-galactoside, cyanidin-3-glucoside, and cyanidin-3-arabinoside) was protective against hydrogen-peroxide-induced apoptosis in H9c2 cells at 10 ng mL-1 (20 nmol L-1) and restored the number of viable cells to match the control group. Anthocyanins 20-32 L1 cell adhesion molecule Mus musculus 211-215 28457017-2 2017 We investigated the activity of physiologically relevant anthocyanin metabolite signatures, derived from a previous pharmacokinetics study of 500 mg 13 C5 -cyanidin-3-glucoside in eight healthy participants, on soluble vascular adhesion molecule-1 (VCAM-1) and interleukin-6 (IL-6) in human endothelial cells. Anthocyanins 57-68 vascular cell adhesion molecule 1 Homo sapiens 219-247 28457017-8 2017 CONCLUSION: Signatures of anthocyanin metabolites following dietary consumption reduce VCAM-1 and IL-6 production, providing evidence of physiologically relevant biological activity. Anthocyanins 26-37 vascular cell adhesion molecule 1 Homo sapiens 87-93 28457017-8 2017 CONCLUSION: Signatures of anthocyanin metabolites following dietary consumption reduce VCAM-1 and IL-6 production, providing evidence of physiologically relevant biological activity. Anthocyanins 26-37 interleukin 6 Homo sapiens 98-102 28731262-0 2017 Nephroprotective Effects of Anthocyanin from the Fruits of Panax ginseng (GFA) on Cisplatin-Induced Acute Kidney Injury in Mice. Anthocyanins 28-39 glutamine fructose-6-phosphate transaminase 1 Mus musculus 74-77 28731262-3 2017 The aim of this research was to survey the nephroprotective effects of anthocyanin from the fruits of Panax ginseng (GFA) in a murine model of cisplatin-induced acute kidney injury. Anthocyanins 71-82 glutamine fructose-6-phosphate transaminase 1 Mus musculus 117-120 28372224-0 2017 Black bean anthocyanin-rich extracts as food colorants: Physicochemical stability and antidiabetes potential. Anthocyanins 11-22 brain expressed associated with NEDD4 1 Homo sapiens 6-10 28372224-2 2017 The objective was to optimize anthocyanins extraction from black bean coats and evaluate their physicochemical stability and antidiabetes potential. Anthocyanins 30-42 brain expressed associated with NEDD4 1 Homo sapiens 65-69 28372224-6 2017 Bean anthocyanins were stable at pH 2.5 and low-temperature 4 C (89.6%), with an extrapolated half-life of 277days. Anthocyanins 5-17 brain expressed associated with NEDD4 1 Homo sapiens 0-4 28372224-7 2017 Anthocyanin-rich extracts inhibited alpha-glucosidase (37.8%), alpha-amylase (35.6%), dipeptidyl peptidase-IV (34.4%), reactive oxygen species (81.6%), and decreased glucose uptake. Anthocyanins 0-11 sucrase-isomaltase Homo sapiens 36-53 28372224-7 2017 Anthocyanin-rich extracts inhibited alpha-glucosidase (37.8%), alpha-amylase (35.6%), dipeptidyl peptidase-IV (34.4%), reactive oxygen species (81.6%), and decreased glucose uptake. Anthocyanins 0-11 dipeptidyl peptidase 4 Homo sapiens 86-109 28372224-8 2017 Black bean coats are a good source of anthocyanins and other phenolics with the potential to be used as natural-source food colorants with exceptional antidiabetes potential. Anthocyanins 38-50 brain expressed associated with NEDD4 1 Homo sapiens 6-10 28797084-1 2017 In soybean, variegated flowers can be caused by somatic excision of the CACTA-type transposable element Tgm9 from Intron 2 of the DFR2 gene encoding dihydroflavonol-4-reductase of the anthocyanin pigment biosynthetic pathway. Anthocyanins 184-195 dihydroflavonol-4-reductase Glycine max 130-134 28797084-1 2017 In soybean, variegated flowers can be caused by somatic excision of the CACTA-type transposable element Tgm9 from Intron 2 of the DFR2 gene encoding dihydroflavonol-4-reductase of the anthocyanin pigment biosynthetic pathway. Anthocyanins 184-195 dihydroflavonol-4-reductase Glycine max 149-176 28384410-6 2017 Each of the 3 major anthocyanins found in lingonberry (cyanidin-3-galactoside, cyanidin-3-glucoside, and cyanidin-3-arabinoside) was protective against hydrogen-peroxide-induced apoptosis in H9c2 cells at 10 ng mL-1 (20 nmol L-1) and restored the number of viable cells to match the control group. Anthocyanins 20-32 L1 cell adhesion molecule Mus musculus 212-215 28317759-6 2017 The strongest protection of gallic acids might be attributed to the shortest distance (4.37A) of its aromatic ring to the anthocyanin (AC) panel. Anthocyanins 135-137 DDB1 and CUL4 associated factor 7 Homo sapiens 122-133 28740990-2 2017 This study investigated the capacity of pure anthocyanins (AC), and berry and rice extracts containing different types and amounts of AC, to inhibit tumor necrosis alpha (TNFalpha)-induced permeabilization of Caco-2 cell monolayers. Anthocyanins 45-57 tumor necrosis factor Homo sapiens 171-179 28745378-1 2017 Previous studies indicated that cyanidin-3-O-beta-glucoside (C3G) as a classical anthocyanin exerted an anti-fibrotic effect in the liver, but its bioavailability was quite low. Anthocyanins 81-92 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 61-64 28740990-2 2017 This study investigated the capacity of pure anthocyanins (AC), and berry and rice extracts containing different types and amounts of AC, to inhibit tumor necrosis alpha (TNFalpha)-induced permeabilization of Caco-2 cell monolayers. Anthocyanins 59-61 tumor necrosis factor Homo sapiens 171-179 28740990-2 2017 This study investigated the capacity of pure anthocyanins (AC), and berry and rice extracts containing different types and amounts of AC, to inhibit tumor necrosis alpha (TNFalpha)-induced permeabilization of Caco-2 cell monolayers. Anthocyanins 134-136 tumor necrosis factor Homo sapiens 171-179 28444442-0 2017 High accumulation of anthocyanins via the ectopic expression of AtDFR confers significant salt stress tolerance in Brassica napus L. KEY MESSAGE: The ectopic expression of AtDFR results in increased accumulation of anthocyanins leading to enhanced salinity and drought stress tolerance in B. napus plants. Anthocyanins 215-227 dihydroflavonol 4-reductase Arabidopsis thaliana 64-69 28444442-0 2017 High accumulation of anthocyanins via the ectopic expression of AtDFR confers significant salt stress tolerance in Brassica napus L. KEY MESSAGE: The ectopic expression of AtDFR results in increased accumulation of anthocyanins leading to enhanced salinity and drought stress tolerance in B. napus plants. Anthocyanins 21-33 dihydroflavonol 4-reductase Arabidopsis thaliana 64-69 28444442-0 2017 High accumulation of anthocyanins via the ectopic expression of AtDFR confers significant salt stress tolerance in Brassica napus L. KEY MESSAGE: The ectopic expression of AtDFR results in increased accumulation of anthocyanins leading to enhanced salinity and drought stress tolerance in B. napus plants. Anthocyanins 21-33 dihydroflavonol 4-reductase Arabidopsis thaliana 172-177 28516293-14 2017 This study provides, for the first time, evidence that the presence of the functional Aft allele, under UV-B radiation, redirects flavonoid synthesis towards anthocyanin production and suggests that the hp-1 allele negatively influences the response of flavonoid biosynthesis to UV-B. Anthocyanins 158-169 DNA damage-binding protein 1 Solanum lycopersicum 203-207 28586465-9 2017 In contrast, pap1-D, which overaccumulates anthocyanins, shows the opposite responses. Anthocyanins 43-55 phosphatidic acid phosphatase 1 Arabidopsis thaliana 13-17 28444442-0 2017 High accumulation of anthocyanins via the ectopic expression of AtDFR confers significant salt stress tolerance in Brassica napus L. KEY MESSAGE: The ectopic expression of AtDFR results in increased accumulation of anthocyanins leading to enhanced salinity and drought stress tolerance in B. napus plants. Anthocyanins 215-227 dihydroflavonol 4-reductase Arabidopsis thaliana 172-177 28444442-5 2017 Increased DFR transcript levels for AtDFR-OX B. shoots correlated with higher anthocyanin accumulation. Anthocyanins 78-89 dihydroflavonol-4-reductase Brassica napus 10-13 28444442-5 2017 Increased DFR transcript levels for AtDFR-OX B. shoots correlated with higher anthocyanin accumulation. Anthocyanins 78-89 dihydroflavonol 4-reductase Arabidopsis thaliana 36-41 28444442-9 2017 Our observations suggested that the AtDFR gene can be effectively manipulated to modulate salinity and drought stress tolerance by directing to high accumulation of anthocyanins in oilseed plants. Anthocyanins 165-177 dihydroflavonol 4-reductase Arabidopsis thaliana 36-41 28274450-5 2017 Sweetheart and Stella cherries demonstrated the greatest bioprotective capacity, suggesting that anthocyanin levels are better markers of a cultivar"s ability to protect human cells from oxidative stress than vitamin C. Anthocyanins 97-108 developmental pluripotency associated 3 Homo sapiens 15-21 28657734-2 2017 Computational analysis suggested that 4 anthocyanins from chokeberry fruit increased Klotho (aging-suppressor) structural stability, so we hypothesized that chokeberry anthocyanins could antiaging. Anthocyanins 40-52 klotho Mus musculus 85-91 28657734-2 2017 Computational analysis suggested that 4 anthocyanins from chokeberry fruit increased Klotho (aging-suppressor) structural stability, so we hypothesized that chokeberry anthocyanins could antiaging. Anthocyanins 168-180 klotho Mus musculus 85-91 28664364-2 2017 The expression level of gene-encoded key regulatory enzymes of flavan-3-ol/anthocyanin biosynthetic pathway, dihydroflavonol 4-reductase (DFR) and anthocyanidin reductase (ANR), has been highly correlated with the flavan-3-ol contents and antioxidant activity in tea plant. Anthocyanins 75-86 dihydroflavonol-4-reductase Nicotiana tabacum 109-136 28698716-0 2017 Corrigendum: The Arabidopsis ANGUSTIFOLIA3-YODA Gene Cascade Induces Anthocyanin Accumulation by Regulating Sucrose Levels. Anthocyanins 69-80 SSXT family protein Arabidopsis thaliana 29-42 28678890-10 2017 Expression of specific transcription factors involved in regulation of anthocyanin synthesis were strongly elevated, e.g. the master regulator PAP1, and intriguingly TT8, which is otherwise mainly expressed in seeds. Anthocyanins 71-82 phosphatidic acid phosphatase 1 Arabidopsis thaliana 143-147 28678890-10 2017 Expression of specific transcription factors involved in regulation of anthocyanin synthesis were strongly elevated, e.g. the master regulator PAP1, and intriguingly TT8, which is otherwise mainly expressed in seeds. Anthocyanins 71-82 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 166-169 28678890-11 2017 The psy2l mutants accumulated anthocyanins under conditions where WT did not, pointing to PSY2L as a possible upstream negative regulator of PAP1 and TT8. Anthocyanins 30-42 phosphatidic acid phosphatase 1 Arabidopsis thaliana 141-145 28678890-11 2017 The psy2l mutants accumulated anthocyanins under conditions where WT did not, pointing to PSY2L as a possible upstream negative regulator of PAP1 and TT8. Anthocyanins 30-42 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 150-153 28074603-5 2017 In vitro results in cultured HK-2 cells confirmed that lingonberry anthocyanins reduced JNK signalling and inflammatory gene expression after IR. Anthocyanins 67-79 mitogen-activated protein kinase 8 Rattus norvegicus 88-91 28670523-12 2017 CONCLUSION: According to the findings of this study, it can be concluded that biological activity of compounds presented in raspberry fruit extract especially anthocyanins may have chemo-protective effect on kidney function and AQP1 expression in rats treated by MTX. Anthocyanins 159-171 aquaporin 1 Rattus norvegicus 228-232 28361257-6 2017 Although the petunia R2R3-MYB factor AN2 induced anthocyanin in both excised leaves and epidermal peels, several transcription factors including maize C1 and Lc inhibited normal anthocyanin development in excised leaves. Anthocyanins 49-60 ent-copalyl diphosphate synthase 2, chloroplastic Zea mays 37-40 28979070-5 2017 Besides, studies showed that phytochemicals such as flavonoids, alkaloids, terpenoids, anthocyanins, glycosides, and phenolic compounds possess significant inhibitory activity against alpha-glucosidase enzyme. Anthocyanins 87-99 sucrase-isomaltase Homo sapiens 184-201 28642775-11 2017 Almost all anthocyanin biosynthetic genes were remarkably upregulated in the leaves and flowers of the transgenic tobacco, and NtAn1a and NtAn1b (two basic helix-loop-helix anthocyanin regulatory genes) were highly expressed in the transformed leaves, compared to the empty vector transformants. Anthocyanins 173-184 basic helix-loop-helix protein A-like Nicotiana tabacum 127-133 28642775-11 2017 Almost all anthocyanin biosynthetic genes were remarkably upregulated in the leaves and flowers of the transgenic tobacco, and NtAn1a and NtAn1b (two basic helix-loop-helix anthocyanin regulatory genes) were highly expressed in the transformed leaves, compared to the empty vector transformants. Anthocyanins 173-184 basic helix-loop-helix protein A-like Nicotiana tabacum 138-144 27167130-8 2017 ANT showed a protective effect on the increase in the pro-inflammatory cytokines content, especially Interleukin (IL)-1beta, tumoral necrosis factor-alpha and on the reduction of IL-10 induced by LPS. Anthocyanins 0-3 interleukin 1 beta Mus musculus 101-123 27167130-8 2017 ANT showed a protective effect on the increase in the pro-inflammatory cytokines content, especially Interleukin (IL)-1beta, tumoral necrosis factor-alpha and on the reduction of IL-10 induced by LPS. Anthocyanins 0-3 interleukin 10 Mus musculus 179-184 28247955-2 2017 Here we show that TTG2 and ARF8 control flower colouring by regulating expression of ANS and DFR genes, which function in anthocyanin biosynthesis. Anthocyanins 122-133 dihydroflavonol-4-reductase Nicotiana tabacum 93-96 28247955-5 2017 Of five genes involved in the anthocyanin biosynthesis pathway, only ANS and DFR were TTG2-regulated and displayed enhancement and diminution of expression with TTG2 overexpression and silencing, respectively. Anthocyanins 30-41 dihydroflavonol-4-reductase Nicotiana tabacum 77-80 28247955-6 2017 The floral expression of ANS and DFR also needed a functional ARF8 gene, as ANS and DFR expression were attenuated by ARF8 silencing, which concomitantly diminished the role of TTG2 in anthocyanin production. Anthocyanins 185-196 dihydroflavonol-4-reductase Nicotiana tabacum 84-87 28247955-8 2017 Our data suggest that TTG2 functions concomitantly with ARF8 to control degrees of flower colour by regulating expression of ANS and DFR, which are involved in the anthocyanin biosynthesis pathway. Anthocyanins 164-175 dihydroflavonol-4-reductase Nicotiana tabacum 133-136 28412546-5 2017 In this work, we demonstrate that prefoldins (PFDs) control the levels of HY5, an Arabidopsis transcription factor with a key role in cold acclimation by activating anthocyanin biosynthesis, in response to low temperature. Anthocyanins 165-176 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 74-77 28412546-7 2017 The degradation of HY5 would result, in turn, in anthocyanin biosynthesis attenuation, ensuring the accurate development of cold acclimation. Anthocyanins 49-60 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 19-22 28361257-6 2017 Although the petunia R2R3-MYB factor AN2 induced anthocyanin in both excised leaves and epidermal peels, several transcription factors including maize C1 and Lc inhibited normal anthocyanin development in excised leaves. Anthocyanins 178-189 ent-copalyl diphosphate synthase 2, chloroplastic Zea mays 37-40 28748082-4 2017 Our previous study found that the anthocyanin delphinidin 3-rutinoside (D3R) significantly increases GLP-1 secretion in GLUTag cells (enteroendocrine L cell line). Anthocyanins 34-45 glucagon Mus musculus 101-106 28475326-10 2017 The bovine serum albumin tannin assay also allows for the estimation of the anthocyanins content with the measurement of small and large polymeric pigments. Anthocyanins 76-88 albumin Homo sapiens 11-24 29228569-6 2017 The protein expression on alpha-SMA, type I collagen, TIMP1 significantly decreased (P < 0.05) following treatment with 50 ug/ml of anthocyanin for 36 h; moreover, the expression of acH3K9, acH3K14 and acH3K18 modification were up-regulated (P < 0.05). Anthocyanins 135-146 TIMP metallopeptidase inhibitor 1 Rattus norvegicus 54-59 28193578-10 2017 We observed that supplementation of HCD with anthocyanin-containing purple-fleshed potatoes (10% w/w), even after baking, suppressed HCD-induced IL-6 expression (P=.03) and the IL-6-related proteins IL-1alpha and Map2k1 (P<=.1). Anthocyanins 45-56 interleukin-6 Sus scrofa 145-149 28193578-10 2017 We observed that supplementation of HCD with anthocyanin-containing purple-fleshed potatoes (10% w/w), even after baking, suppressed HCD-induced IL-6 expression (P=.03) and the IL-6-related proteins IL-1alpha and Map2k1 (P<=.1). Anthocyanins 45-56 interleukin-6 Sus scrofa 177-181 28193578-10 2017 We observed that supplementation of HCD with anthocyanin-containing purple-fleshed potatoes (10% w/w), even after baking, suppressed HCD-induced IL-6 expression (P=.03) and the IL-6-related proteins IL-1alpha and Map2k1 (P<=.1). Anthocyanins 45-56 interleukin 1 alpha Sus scrofa 199-208 28208071-0 2017 Anthocyanin suppresses CoCrMo particle-induced osteolysis by inhibiting IKKalpha/beta mediated NF-kappaB signaling in a mouse calvarial model. Anthocyanins 0-11 conserved helix-loop-helix ubiquitous kinase Mus musculus 72-85 28208071-0 2017 Anthocyanin suppresses CoCrMo particle-induced osteolysis by inhibiting IKKalpha/beta mediated NF-kappaB signaling in a mouse calvarial model. Anthocyanins 0-11 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 95-104 28208071-7 2017 Anthocyanin also reversed the increase in the ratio of receptor activator of nuclear factor kappa B ligand (RANKL)/osteoproteger (OPG) and suppressed osteoclast formation in CoCrMo particle-stimulated calvaria. Anthocyanins 0-11 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 55-106 28208071-7 2017 Anthocyanin also reversed the increase in the ratio of receptor activator of nuclear factor kappa B ligand (RANKL)/osteoproteger (OPG) and suppressed osteoclast formation in CoCrMo particle-stimulated calvaria. Anthocyanins 0-11 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 108-113 28208071-8 2017 Additionally, anthocyanin significantly reduced the expression and secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the calvaria of CoCrMo-stimulated mice. Anthocyanins 14-25 tumor necrosis factor Mus musculus 80-107 28208071-8 2017 Additionally, anthocyanin significantly reduced the expression and secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the calvaria of CoCrMo-stimulated mice. Anthocyanins 14-25 tumor necrosis factor Mus musculus 109-118 28208071-8 2017 Additionally, anthocyanin significantly reduced the expression and secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the calvaria of CoCrMo-stimulated mice. Anthocyanins 14-25 interleukin 1 beta Mus musculus 121-138 28208071-8 2017 Additionally, anthocyanin significantly reduced the expression and secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the calvaria of CoCrMo-stimulated mice. Anthocyanins 14-25 interleukin 1 beta Mus musculus 140-148 28208071-8 2017 Additionally, anthocyanin significantly reduced the expression and secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the calvaria of CoCrMo-stimulated mice. Anthocyanins 14-25 interleukin 6 Mus musculus 154-167 28208071-8 2017 Additionally, anthocyanin significantly reduced the expression and secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the calvaria of CoCrMo-stimulated mice. Anthocyanins 14-25 interleukin 6 Mus musculus 169-173 28208071-9 2017 Furthermore, we confirmed that anthocyanin attenuated osteolysis by blocking NF-kappaB pathway via inhibiting inhibitor of nuclear factor kappa-B kinase alpha/beta (IKKalpha/beta) phosphorylation. Anthocyanins 31-42 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 77-86 28208071-9 2017 Furthermore, we confirmed that anthocyanin attenuated osteolysis by blocking NF-kappaB pathway via inhibiting inhibitor of nuclear factor kappa-B kinase alpha/beta (IKKalpha/beta) phosphorylation. Anthocyanins 31-42 conserved helix-loop-helix ubiquitous kinase Mus musculus 138-178 28208071-10 2017 In conclusion, our study demonstrated that anthocyanin can protect against CoCrMo particle-induced inflammatory osteolysis via inhibiting the IKKalpha/beta-NF-kappaB pathway, and have a potential therapeutic effect on the treatment of wear particle-induced osteolysis. Anthocyanins 43-54 conserved helix-loop-helix ubiquitous kinase Mus musculus 142-150 28208071-10 2017 In conclusion, our study demonstrated that anthocyanin can protect against CoCrMo particle-induced inflammatory osteolysis via inhibiting the IKKalpha/beta-NF-kappaB pathway, and have a potential therapeutic effect on the treatment of wear particle-induced osteolysis. Anthocyanins 43-54 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 156-165 28257977-8 2017 Hypoglycemic effects of fruits and vegetables may be due to their inducing nature on pancreatic beta-cells for insulin secretion, or bioactive compounds such as flavonoids, alkaloids and anthocyanins, which act as insulin-like molecules or insulin secretagogues. Anthocyanins 187-199 insulin Homo sapiens 214-221 28435067-0 2017 The mitogen-activated protein kinase kinase 9 (MKK9) modulates nitrogen acquisition and anthocyanin accumulation under nitrogen-limiting condition in Arabidopsis. Anthocyanins 88-99 MAP kinase kinase 9 Arabidopsis thaliana 47-51 28216162-0 2017 Genome-wide identification of GLABRA3 downstream genes for anthocyanin biosynthesis and trichome formation in Arabidopsis. Anthocyanins 59-70 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 30-37 28435067-3 2017 Here, we show that the mitogen-activated protein kinase kinase 9 (MKK9) is involved in plant N responses in Arabidopsis by regulating production of anthocyanins and the ability of N acquisition under low N conditions. Anthocyanins 148-160 MAP kinase kinase 9 Arabidopsis thaliana 66-70 28435067-4 2017 Transgenic plants that express a constitutively active version of MKK9 (MKK9DD) showed decreased accumulation of anthocynanins and reduced expression of key anthocyanin biosynthetic genes under low N condition compared to the plants expressing the inactive form of MKK9 (MKK9KR). Anthocyanins 157-168 MAP kinase kinase 9 Arabidopsis thaliana 66-70 28435067-4 2017 Transgenic plants that express a constitutively active version of MKK9 (MKK9DD) showed decreased accumulation of anthocynanins and reduced expression of key anthocyanin biosynthetic genes under low N condition compared to the plants expressing the inactive form of MKK9 (MKK9KR). Anthocyanins 157-168 MAP kinase kinase 9 Arabidopsis thaliana 72-76 28435067-6 2017 Taken together, our results suggest that MKK9 plays a role in plant adaptation to low N stress by modulating both anthocyanin accumulation and N status. Anthocyanins 114-125 MAP kinase kinase 9 Arabidopsis thaliana 41-45 28303711-7 2017 Isolated anthocyanins and procyanidins are strong radical scavengers and are good inhibitors of 15-lipoxygenase and moderate inhibitors of xanthine oxidase. Anthocyanins 9-21 arachidonate 15-lipoxygenase Homo sapiens 96-111 28379159-1 2017 Anthocyanins are pigments with antihyperglycemic properties, and they are potential candidates for developing functional foods for the therapy or prevention of Diabetes mellitus type 2 (DM2). Anthocyanins 0-12 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 160-184 28379159-1 2017 Anthocyanins are pigments with antihyperglycemic properties, and they are potential candidates for developing functional foods for the therapy or prevention of Diabetes mellitus type 2 (DM2). Anthocyanins 0-12 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 186-189 28216162-1 2017 GLABRA3 (GL3), a bHLH transcription factor, has previously proved to be involved in anthocyanin biosynthesis and trichome formation in Arabidopsis, however, its downstream targeted genes are still largely unknown. Anthocyanins 84-95 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 0-7 28216162-1 2017 GLABRA3 (GL3), a bHLH transcription factor, has previously proved to be involved in anthocyanin biosynthesis and trichome formation in Arabidopsis, however, its downstream targeted genes are still largely unknown. Anthocyanins 84-95 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 9-12 28216162-3 2017 New downstream targeted genes of GL3 for anthocyanin biosynthesis and trichome formation were identified in young shoots and expanding true leaves by RNA sequencing. Anthocyanins 41-52 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 33-36 28216162-5 2017 This study provides new clues to further understand the GL3-mediated regulatory network of anthocyanin biosynthesis and trichome formation in Arabidopsis. Anthocyanins 91-102 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 56-59 28009871-10 2017 IL-1beta, IL-6 and TNF-alpha protein expressions were also reduced in TNF-alpha-treated CCD-18Co cells by CP anthocyanins at 20.0 mug ml-1 GAE. Anthocyanins 109-121 tumor necrosis factor Homo sapiens 19-28 28108596-4 2017 Here, we evaluated the potency of the CD38 inhibitor luteolinidin, an anthocyanidin, at blocking CD38 activity and preserving endothelial and myocardial function in the postischemic heart. Anthocyanins 70-83 CD38 molecule Homo sapiens 38-42 26613119-7 2017 Anthocyanins and their aglycons, responsible for the typical color of berries, inhibit MAO isoforms A or B with IC50 values corresponding to the micromolar range. Anthocyanins 0-12 monoamine oxidase A Rattus norvegicus 87-90 28275852-1 2017 KEY MESSAGE: DELLA proteins positively regulate nitrogen deficiency-induced anthocyanin accumulation through directly interaction with PAP1 to enhance its transcriptional activity on anthocyanin biosynthetic gene expressions. Anthocyanins 76-87 phosphatidic acid phosphatase 1 Arabidopsis thaliana 135-139 28275852-1 2017 KEY MESSAGE: DELLA proteins positively regulate nitrogen deficiency-induced anthocyanin accumulation through directly interaction with PAP1 to enhance its transcriptional activity on anthocyanin biosynthetic gene expressions. Anthocyanins 183-194 phosphatidic acid phosphatase 1 Arabidopsis thaliana 135-139 28275852-6 2017 Moreover, the nitrogen deficiency-induced anthocyanin accumulation and biosynthesis gene expressions were impaired in the loss-of-function mutant gai-t6/rga-t2/rgl1-1/rgl2-1/rgl3-1 (della) but enhanced in the GA-insensitive mutant gai, suggesting that DELLA proteins, known as repressors of GA signaling, are necessary for fully induction of nitrogen deficiency-driven anthocyanin biosynthesis. Anthocyanins 42-53 GRAS family transcription factor family protein Arabidopsis thaliana 146-149 28275852-6 2017 Moreover, the nitrogen deficiency-induced anthocyanin accumulation and biosynthesis gene expressions were impaired in the loss-of-function mutant gai-t6/rga-t2/rgl1-1/rgl2-1/rgl3-1 (della) but enhanced in the GA-insensitive mutant gai, suggesting that DELLA proteins, known as repressors of GA signaling, are necessary for fully induction of nitrogen deficiency-driven anthocyanin biosynthesis. Anthocyanins 42-53 GRAS family transcription factor family protein Arabidopsis thaliana 153-156 28275852-6 2017 Moreover, the nitrogen deficiency-induced anthocyanin accumulation and biosynthesis gene expressions were impaired in the loss-of-function mutant gai-t6/rga-t2/rgl1-1/rgl2-1/rgl3-1 (della) but enhanced in the GA-insensitive mutant gai, suggesting that DELLA proteins, known as repressors of GA signaling, are necessary for fully induction of nitrogen deficiency-driven anthocyanin biosynthesis. Anthocyanins 42-53 RGA-like 1 Arabidopsis thaliana 160-166 28275852-6 2017 Moreover, the nitrogen deficiency-induced anthocyanin accumulation and biosynthesis gene expressions were impaired in the loss-of-function mutant gai-t6/rga-t2/rgl1-1/rgl2-1/rgl3-1 (della) but enhanced in the GA-insensitive mutant gai, suggesting that DELLA proteins, known as repressors of GA signaling, are necessary for fully induction of nitrogen deficiency-driven anthocyanin biosynthesis. Anthocyanins 42-53 GRAS family transcription factor family protein Arabidopsis thaliana 231-234 28275852-6 2017 Moreover, the nitrogen deficiency-induced anthocyanin accumulation and biosynthesis gene expressions were impaired in the loss-of-function mutant gai-t6/rga-t2/rgl1-1/rgl2-1/rgl3-1 (della) but enhanced in the GA-insensitive mutant gai, suggesting that DELLA proteins, known as repressors of GA signaling, are necessary for fully induction of nitrogen deficiency-driven anthocyanin biosynthesis. Anthocyanins 369-380 GRAS family transcription factor family protein Arabidopsis thaliana 146-149 28275852-6 2017 Moreover, the nitrogen deficiency-induced anthocyanin accumulation and biosynthesis gene expressions were impaired in the loss-of-function mutant gai-t6/rga-t2/rgl1-1/rgl2-1/rgl3-1 (della) but enhanced in the GA-insensitive mutant gai, suggesting that DELLA proteins, known as repressors of GA signaling, are necessary for fully induction of nitrogen deficiency-driven anthocyanin biosynthesis. Anthocyanins 369-380 GRAS family transcription factor family protein Arabidopsis thaliana 153-156 28275852-6 2017 Moreover, the nitrogen deficiency-induced anthocyanin accumulation and biosynthesis gene expressions were impaired in the loss-of-function mutant gai-t6/rga-t2/rgl1-1/rgl2-1/rgl3-1 (della) but enhanced in the GA-insensitive mutant gai, suggesting that DELLA proteins, known as repressors of GA signaling, are necessary for fully induction of nitrogen deficiency-driven anthocyanin biosynthesis. Anthocyanins 369-380 RGA-like 1 Arabidopsis thaliana 160-166 28275852-7 2017 Using yeast two-hybrid (Y2H) assay, pull-down assay, and luciferase complementation assay, it was found that RGA, a DELLA of Arabidopsis, could strongly interact with PAP1, a known regulatory transcription factor positively involved in anthocyanin biosynthesis. Anthocyanins 236-247 GRAS family transcription factor family protein Arabidopsis thaliana 109-112 28275852-7 2017 Using yeast two-hybrid (Y2H) assay, pull-down assay, and luciferase complementation assay, it was found that RGA, a DELLA of Arabidopsis, could strongly interact with PAP1, a known regulatory transcription factor positively involved in anthocyanin biosynthesis. Anthocyanins 236-247 phosphatidic acid phosphatase 1 Arabidopsis thaliana 167-171 28275852-9 2017 Taken together, this study suggests that DELLAs are necessary regulators for nitrogen deficiency-induced anthocyanin accumulation through interaction with PAP1 and enhancement of PAP1"s transcriptional activity on its target genes. Anthocyanins 105-116 phosphatidic acid phosphatase 1 Arabidopsis thaliana 155-159 28275852-9 2017 Taken together, this study suggests that DELLAs are necessary regulators for nitrogen deficiency-induced anthocyanin accumulation through interaction with PAP1 and enhancement of PAP1"s transcriptional activity on its target genes. Anthocyanins 105-116 phosphatidic acid phosphatase 1 Arabidopsis thaliana 179-183 28400785-1 2017 Dihydroflavonol-4-reductase (DFR) is a key enzyme in the reduction of dihydroflavonols to leucoanthocyanidins in both anthocyanin biosynthesis and proanthocyanidin accumulation. Anthocyanins 90-109 dihydroflavonol 4-reductase Arabidopsis thaliana 0-27 28400785-1 2017 Dihydroflavonol-4-reductase (DFR) is a key enzyme in the reduction of dihydroflavonols to leucoanthocyanidins in both anthocyanin biosynthesis and proanthocyanidin accumulation. Anthocyanins 90-109 dihydroflavonol 4-reductase Arabidopsis thaliana 29-32 28400785-1 2017 Dihydroflavonol-4-reductase (DFR) is a key enzyme in the reduction of dihydroflavonols to leucoanthocyanidins in both anthocyanin biosynthesis and proanthocyanidin accumulation. Anthocyanins 118-129 dihydroflavonol 4-reductase Arabidopsis thaliana 0-27 28400785-1 2017 Dihydroflavonol-4-reductase (DFR) is a key enzyme in the reduction of dihydroflavonols to leucoanthocyanidins in both anthocyanin biosynthesis and proanthocyanidin accumulation. Anthocyanins 118-129 dihydroflavonol 4-reductase Arabidopsis thaliana 29-32 28329021-6 2017 The strong inhibition of COX-2 expression seems to be a crucial anti-inflammatory mechanism common to both ARF and 5-ASA, but the additional higher abilities of anthocyanins to downregulate iNOS and to decrease leukocytes infiltration and to increase antioxidant defenses in colon may account for the much higher anti-inflammatory action of anthocyanins. Anthocyanins 161-173 nitric oxide synthase 2 Rattus norvegicus 190-194 28253311-0 2017 Calmodulin-binding protein CBP60g functions as a negative regulator in Arabidopsis anthocyanin accumulation. Anthocyanins 83-94 Cam-binding protein 60-like G Arabidopsis thaliana 27-33 28253311-4 2017 In this study, we found that CBP60g repressed anthocyanin accumulation induced by drought, sucrose and kinetin. Anthocyanins 46-57 Cam-binding protein 60-like G Arabidopsis thaliana 29-35 28253311-5 2017 The expression pattern of CBP60g was in accordance with the anthocyanin accumulation tissues. Anthocyanins 60-71 Cam-binding protein 60-like G Arabidopsis thaliana 26-32 28253311-6 2017 Real-time qPCR analysis revealed that the anthocyanin biosynthetic genes CHS, CHI and DFR, as well as two members of MBW complex, PAP1, a MYB transcription factor, and TT8, a bHLH transcription factor, were down regulated by CBP60g. Anthocyanins 42-53 dihydroflavonol 4-reductase Arabidopsis thaliana 86-89 28253311-6 2017 Real-time qPCR analysis revealed that the anthocyanin biosynthetic genes CHS, CHI and DFR, as well as two members of MBW complex, PAP1, a MYB transcription factor, and TT8, a bHLH transcription factor, were down regulated by CBP60g. Anthocyanins 42-53 Cam-binding protein 60-like G Arabidopsis thaliana 225-231 28011403-4 2017 The present study examined, at a molecular level, the effects of cyanidin-3-O-glucoside (C3G), a widely distributed anthocyanin, on PA-induced endothelial dysfunction and insulin resistance in human umbilical vein endothelial cells (HUVECs). Anthocyanins 116-127 Rap guanine nucleotide exchange factor 1 Homo sapiens 89-92 27649384-0 2017 Anthocyanidins inhibit epithelial-mesenchymal transition through a TGFbeta/Smad2 signaling pathway in glioblastoma cells. Anthocyanins 0-14 transforming growth factor beta 1 Homo sapiens 67-74 27649384-0 2017 Anthocyanidins inhibit epithelial-mesenchymal transition through a TGFbeta/Smad2 signaling pathway in glioblastoma cells. Anthocyanins 0-14 SMAD family member 2 Homo sapiens 75-80 27649384-3 2017 Despite the well-known role of transforming growth factor-beta (TGF-beta) in high grade gliomas, the impact of anthocyanidins on TGF-beta-induced epithelial-mesenchymal transition (EMT), a process that allows benign tumor cells to infiltrate surrounding tissues, remains poorly understood. Anthocyanins 111-125 transforming growth factor beta 1 Homo sapiens 129-137 27649384-5 2017 Human U-87 glioblastoma (U-87 MG) cells were treated with anthocyanidins prior to, along with or following the addition of TGF-beta. Anthocyanins 58-72 small nucleolar RNA, C/D box 87 Homo sapiens 6-29 27649384-6 2017 We found that anthocyanidins differently affected TGF-beta-induced EMT, depending on the treatment conditions. Anthocyanins 14-28 transforming growth factor beta 1 Homo sapiens 50-58 28131062-3 2017 It is well established that anthocyanin biosynthesis is regulated by the interplay between MYB and bHLH transcription factors (TF) in most plants. Anthocyanins 28-39 MYB proto-oncogene, transcription factor Homo sapiens 91-94 28173812-0 2017 Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Abeta1-42-induced oxidative stress. Anthocyanins 0-12 mitogen-activated protein kinase 14 Homo sapiens 118-121 28173812-0 2017 Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Abeta1-42-induced oxidative stress. Anthocyanins 0-12 mitogen-activated protein kinase 8 Homo sapiens 122-125 28009871-10 2017 IL-1beta, IL-6 and TNF-alpha protein expressions were also reduced in TNF-alpha-treated CCD-18Co cells by CP anthocyanins at 20.0 mug ml-1 GAE. Anthocyanins 109-121 tumor necrosis factor Homo sapiens 70-79 28009871-10 2017 IL-1beta, IL-6 and TNF-alpha protein expressions were also reduced in TNF-alpha-treated CCD-18Co cells by CP anthocyanins at 20.0 mug ml-1 GAE. Anthocyanins 109-121 interleukin 17F Homo sapiens 134-138 28373746-4 2017 Many papers reported that anthocyanins, a group of compounds belonging to flavonoids, possess anti-inflammatory effects and modulate NF-kappaB activity. Anthocyanins 26-38 nuclear factor kappa B subunit 1 Homo sapiens 133-142 28053648-4 2017 RESULTS: We improved the VIGS system based on the tobacco rattle virus (TRV) containing the An2 MYB transcription factor, which is the genetic determinant of purple colored- or anthocyanin-rich pepper. Anthocyanins 177-188 paired box 6 Homo sapiens 92-95 28053648-5 2017 Silencing of endogenous An2 in the anthocyanin-rich pepper with the modified TRV vector for ligation-independent cloning (LIC) lacked purple pigment in its leaves, flowers, and fruits. Anthocyanins 35-46 paired box 6 Homo sapiens 24-27 28053648-8 2017 CONCLUSIONS: VIGS with tandem constructs harboring An2 as a visible reporter in anthocyanin-rich pepper plants can facilitate the application of functional genomics in the study of metabolic pathways and fruit biology. Anthocyanins 80-91 paired box 6 Homo sapiens 51-54 26424400-0 2017 Possible Effects of Dietary Anthocyanins on Diabetes and Insulin Resistance. Anthocyanins 28-40 insulin Homo sapiens 57-64 26738855-9 2017 Furthermore, the results also indicated that anthocyanins inhibited activated astrocytes and neuroinflammation via suppression of various inflammatory markers including p-NF- K B, inducible nitric oxide synthase (iNOS), and tumor necrosis factor-alpha (TNF-alpha) in the hippocampus and cortex regions of D-gal-treated rats brain. Anthocyanins 45-57 nitric oxide synthase 2 Rattus norvegicus 180-211 26738855-9 2017 Furthermore, the results also indicated that anthocyanins inhibited activated astrocytes and neuroinflammation via suppression of various inflammatory markers including p-NF- K B, inducible nitric oxide synthase (iNOS), and tumor necrosis factor-alpha (TNF-alpha) in the hippocampus and cortex regions of D-gal-treated rats brain. Anthocyanins 45-57 nitric oxide synthase 2 Rattus norvegicus 213-217 26738855-9 2017 Furthermore, the results also indicated that anthocyanins inhibited activated astrocytes and neuroinflammation via suppression of various inflammatory markers including p-NF- K B, inducible nitric oxide synthase (iNOS), and tumor necrosis factor-alpha (TNF-alpha) in the hippocampus and cortex regions of D-gal-treated rats brain. Anthocyanins 45-57 tumor necrosis factor Rattus norvegicus 224-251 26738855-9 2017 Furthermore, the results also indicated that anthocyanins inhibited activated astrocytes and neuroinflammation via suppression of various inflammatory markers including p-NF- K B, inducible nitric oxide synthase (iNOS), and tumor necrosis factor-alpha (TNF-alpha) in the hippocampus and cortex regions of D-gal-treated rats brain. Anthocyanins 45-57 tumor necrosis factor Rattus norvegicus 253-262 26738855-10 2017 Moreover, anthocyanins abrogated neuroapoptosis via C-jun N-terminal kinase (p-JNK) suppression and improved deregulated synaptic proteins including synaptophysin, synaptosomal-associated protein (SNAP)-23, SNAP-25, and phosphorylated CREB. Anthocyanins 10-22 synaptophysin Rattus norvegicus 149-162 26738855-10 2017 Moreover, anthocyanins abrogated neuroapoptosis via C-jun N-terminal kinase (p-JNK) suppression and improved deregulated synaptic proteins including synaptophysin, synaptosomal-associated protein (SNAP)-23, SNAP-25, and phosphorylated CREB. Anthocyanins 10-22 synaptosome associated protein 23 Rattus norvegicus 164-205 26738855-10 2017 Moreover, anthocyanins abrogated neuroapoptosis via C-jun N-terminal kinase (p-JNK) suppression and improved deregulated synaptic proteins including synaptophysin, synaptosomal-associated protein (SNAP)-23, SNAP-25, and phosphorylated CREB. Anthocyanins 10-22 synaptosome associated protein 25 Rattus norvegicus 207-214 26738855-10 2017 Moreover, anthocyanins abrogated neuroapoptosis via C-jun N-terminal kinase (p-JNK) suppression and improved deregulated synaptic proteins including synaptophysin, synaptosomal-associated protein (SNAP)-23, SNAP-25, and phosphorylated CREB. Anthocyanins 10-22 cAMP responsive element binding protein 1 Rattus norvegicus 235-239 29230268-5 2017 The good inhibition effect of the dried extract on the AGE formation and the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid extract compounds and was improved by the use of alginate and cyclodextrin. Anthocyanins 157-168 matrix metallopeptidase 2 Homo sapiens 77-82 29230268-5 2017 The good inhibition effect of the dried extract on the AGE formation and the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid extract compounds and was improved by the use of alginate and cyclodextrin. Anthocyanins 157-168 matrix metallopeptidase 9 Homo sapiens 87-92 27229540-2 2017 Arabidopsis PAP1 (production of anthocyanin pigment 1) gene (AtPAP1) encodes a R2R3-type MYB transcript factor that is a master component of regulatory complexes controlling anthocyanin biosynthesis. Anthocyanins 32-43 production of anthocyanin pigment 1 Arabidopsis thaliana 12-16 27229540-2 2017 Arabidopsis PAP1 (production of anthocyanin pigment 1) gene (AtPAP1) encodes a R2R3-type MYB transcript factor that is a master component of regulatory complexes controlling anthocyanin biosynthesis. Anthocyanins 32-43 phosphatidic acid phosphatase 1 Arabidopsis thaliana 61-67 27229540-7 2017 Spectrophotometric measurement showed that the amount of anthocyanins in AtPAP1 transgenic plants were 400-800 microg g-1 fresh weight (FW). Anthocyanins 57-69 phosphatidic acid phosphatase 1 Arabidopsis thaliana 73-79 27229540-11 2017 This study shows that AtPAP1 is of significance for metabolic engineering of anthocyanins in crop plants for value-added traits. Anthocyanins 77-89 phosphatidic acid phosphatase 1 Arabidopsis thaliana 22-28 27599367-8 2017 Taken together, we demonstrate that UGT79B2 and UGT79B3, identified as anthocyanin rhamnosyltransferases, are regulated by CBF1 and confer abiotic stress tolerance via modulating anthocyanin accumulation. Anthocyanins 71-82 C-repeat/DRE binding factor 1 Arabidopsis thaliana 123-127 28066458-2 2016 Anthocyanidin synthase (Ans) catalyzes the conversion of leucoanthocyanidin to anthocyanidin, a key committed step in biosynthesis of anthocyanins. Anthocyanins 57-75 leucoanthocyanidin dioxygenase Arabidopsis thaliana 24-27 28066458-2 2016 Anthocyanidin synthase (Ans) catalyzes the conversion of leucoanthocyanidin to anthocyanidin, a key committed step in biosynthesis of anthocyanins. Anthocyanins 62-75 leucoanthocyanidin dioxygenase Arabidopsis thaliana 24-27 28066458-2 2016 Anthocyanidin synthase (Ans) catalyzes the conversion of leucoanthocyanidin to anthocyanidin, a key committed step in biosynthesis of anthocyanins. Anthocyanins 134-146 leucoanthocyanidin dioxygenase Arabidopsis thaliana 24-27 28066458-8 2016 Functional characterization of raspberry Ans/ans alleles via complementation experiments in the Arabidopsis thaliana ldox mutant supports the inactivity of encoded protein through ans+5 and explains the proposed block in the anthocyanin biosynthetic pathway in raspberry. Anthocyanins 225-236 leucoanthocyanidin dioxygenase Arabidopsis thaliana 41-44 28066458-8 2016 Functional characterization of raspberry Ans/ans alleles via complementation experiments in the Arabidopsis thaliana ldox mutant supports the inactivity of encoded protein through ans+5 and explains the proposed block in the anthocyanin biosynthetic pathway in raspberry. Anthocyanins 225-236 leucoanthocyanidin dioxygenase Arabidopsis thaliana 45-48 27847126-0 2016 Effects of blueberry anthocyanins on retinal oxidative stress and inflammation in diabetes through Nrf2/HO-1 signaling. Anthocyanins 21-33 NFE2 like bZIP transcription factor 2 Rattus norvegicus 99-103 27847126-0 2016 Effects of blueberry anthocyanins on retinal oxidative stress and inflammation in diabetes through Nrf2/HO-1 signaling. Anthocyanins 21-33 heme oxygenase 1 Rattus norvegicus 104-108 27821173-8 2016 In contrast, anthocyanin co-treatment significantly reduced glutamate-induced AMPK induction, ROS production, neuroinflammation, and neurodegeneration in the developing rat brain. Anthocyanins 13-24 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 78-82 27995376-0 2017 Double-stranded RNA-binding protein DRB3 negatively regulates anthocyanin biosynthesis by modulating PAP1 expression in Arabidopsis thaliana. Anthocyanins 62-73 dsRNA-binding protein 3 Arabidopsis thaliana 36-40 27995376-7 2017 When these plants were exposed to cold stress, drb2 and drb3 over-accumulated anthocyanin but DRB2ox and DRB3ox did not. Anthocyanins 78-89 dsRNA-binding protein 2 Arabidopsis thaliana 47-51 27995376-7 2017 When these plants were exposed to cold stress, drb2 and drb3 over-accumulated anthocyanin but DRB2ox and DRB3ox did not. Anthocyanins 78-89 dsRNA-binding protein 3 Arabidopsis thaliana 56-60 27995376-9 2017 Microarray and deep-sequencing analyses indicated that several genes encoding key enzymes for anthocyanin biosynthesis, including chalcone synthase (CHS), dihydroflavonol reductase (DFR) and anthocyanidin synthase (ANS), were down-regulated in DRB3ox plants. Anthocyanins 94-105 Chalcone and stilbene synthase family protein Arabidopsis thaliana 130-147 27995376-9 2017 Microarray and deep-sequencing analyses indicated that several genes encoding key enzymes for anthocyanin biosynthesis, including chalcone synthase (CHS), dihydroflavonol reductase (DFR) and anthocyanidin synthase (ANS), were down-regulated in DRB3ox plants. Anthocyanins 94-105 Chalcone and stilbene synthase family protein Arabidopsis thaliana 149-152 27995376-9 2017 Microarray and deep-sequencing analyses indicated that several genes encoding key enzymes for anthocyanin biosynthesis, including chalcone synthase (CHS), dihydroflavonol reductase (DFR) and anthocyanidin synthase (ANS), were down-regulated in DRB3ox plants. Anthocyanins 94-105 dihydroflavonol 4-reductase Arabidopsis thaliana 155-180 27995376-9 2017 Microarray and deep-sequencing analyses indicated that several genes encoding key enzymes for anthocyanin biosynthesis, including chalcone synthase (CHS), dihydroflavonol reductase (DFR) and anthocyanidin synthase (ANS), were down-regulated in DRB3ox plants. Anthocyanins 94-105 dihydroflavonol 4-reductase Arabidopsis thaliana 182-185 27995376-9 2017 Microarray and deep-sequencing analyses indicated that several genes encoding key enzymes for anthocyanin biosynthesis, including chalcone synthase (CHS), dihydroflavonol reductase (DFR) and anthocyanidin synthase (ANS), were down-regulated in DRB3ox plants. Anthocyanins 94-105 leucoanthocyanidin dioxygenase Arabidopsis thaliana 191-213 27995376-9 2017 Microarray and deep-sequencing analyses indicated that several genes encoding key enzymes for anthocyanin biosynthesis, including chalcone synthase (CHS), dihydroflavonol reductase (DFR) and anthocyanidin synthase (ANS), were down-regulated in DRB3ox plants. Anthocyanins 94-105 dsRNA-binding protein 3 Arabidopsis thaliana 244-248 27995376-10 2017 When DRB3ox was crossed with the pap1-D line, which is an activation-tagged transgenic line that over-expresses the key transcription factor PAP1 (Production of anthocyanin pigmentation1) for anthocyanin biosynthesis, over-expression of DRB3 suppressed the expression of PAP1, CHS, DFR and ANS genes. Anthocyanins 192-203 dsRNA-binding protein 3 Arabidopsis thaliana 5-11 27995376-10 2017 When DRB3ox was crossed with the pap1-D line, which is an activation-tagged transgenic line that over-expresses the key transcription factor PAP1 (Production of anthocyanin pigmentation1) for anthocyanin biosynthesis, over-expression of DRB3 suppressed the expression of PAP1, CHS, DFR and ANS genes. Anthocyanins 192-203 dsRNA-binding protein 3 Arabidopsis thaliana 5-9 27995376-11 2017 DRB3 negatively regulates anthocyanin biosynthesis by modulating the level of PAP1 transcript. Anthocyanins 26-37 dsRNA-binding protein 3 Arabidopsis thaliana 0-4 27999588-7 2016 In addition, anthocyanin accumulation was inhibited by downregulating the expression of genes involved in its biosynthesis and by interplaying between the CBF3 and the endogenous transcription factors. Anthocyanins 13-24 dehydration response element B1A Arabidopsis thaliana 155-159 27720844-5 2016 ADT2 contributes the most to anthocyanin accumulation, followed by ADT1 and ADT3, and ADT4-ADT6. Anthocyanins 29-40 arogenate dehydratase 2 Arabidopsis thaliana 0-4 27720844-7 2016 Consistently, addition of Phe to the medium could dramatically increase anthocyanin content in the wild-type plants and rescue the phenotype of the adt1 adt3 double mutant regarding the anthocyanin accumulation. Anthocyanins 186-197 arogenate dehydratase 1 Arabidopsis thaliana 148-157 27720844-8 2016 Moreover, transgenic plants overexpressing ADT4, which appears to be less sensitive to Phe than overexpression of ADT2, hyperaccumulate Phe and produce elevated level of anthocyanins. Anthocyanins 170-182 arogenate dehydratase 4 Arabidopsis thaliana 43-47 27966737-7 2016 Moreover, correlation analysis indicated that the transcriptional and translational expression levels of the VvmybA2 gene were significantly positively correlated with not only UFGT and DFR genes but also with the anthocyanin content during berry development. Anthocyanins 214-225 LOW QUALITY PROTEIN: transcription factor MYB90 Vitis vinifera 109-116 27764725-0 2016 Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations. Anthocyanins 18-29 insulin Homo sapiens 93-100 28009871-4 2017 The objective of this study was to assess the anti-inflammatory and anti-proliferative activities of anthocyanins extracted from CP (1.0 to 20.0 mug ml-1 gallic acid equivalents [GAE]) in CCD-18Co non-malignant colonic fibroblasts and HT-29 colorectal adenocarcinoma cells. Anthocyanins 101-113 interleukin 17F Homo sapiens 149-153 28009871-10 2017 IL-1beta, IL-6 and TNF-alpha protein expressions were also reduced in TNF-alpha-treated CCD-18Co cells by CP anthocyanins at 20.0 mug ml-1 GAE. Anthocyanins 109-121 interleukin 1 beta Homo sapiens 0-8 28009871-10 2017 IL-1beta, IL-6 and TNF-alpha protein expressions were also reduced in TNF-alpha-treated CCD-18Co cells by CP anthocyanins at 20.0 mug ml-1 GAE. Anthocyanins 109-121 interleukin 6 Homo sapiens 10-14 27933092-7 2016 In addition, a positive correlation was observed between the decreases in the CXCL12 and tumornecrosis factor-alpha (TNF-alpha) levels after anthocyanin supplementation. Anthocyanins 141-152 C-X-C motif chemokine ligand 12 Homo sapiens 78-84 27933092-5 2016 Interestingly, the decreases in the CXCL7 and CCL2 levels were both positively correlated with the decreases in the serum low-density lipoprotein-cholesterol (LDL-C), high-sensitivity C-reactive protein (hsCRP) and interleukin-1beta (IL-1beta) levels after anthocyanin supplementation for 24 weeks. Anthocyanins 257-268 pro-platelet basic protein Homo sapiens 36-41 27933092-5 2016 Interestingly, the decreases in the CXCL7 and CCL2 levels were both positively correlated with the decreases in the serum low-density lipoprotein-cholesterol (LDL-C), high-sensitivity C-reactive protein (hsCRP) and interleukin-1beta (IL-1beta) levels after anthocyanin supplementation for 24 weeks. Anthocyanins 257-268 C-C motif chemokine ligand 2 Homo sapiens 46-50 27933092-6 2016 The decrease in the CXCL8 level was negatively correlated with the increase in the how-density lipoprotein-cholesterol (HDL-C) level and was positively correlated with the decrease in the soluble P-selectin (sP-selectin) level in the anthocyanin group. Anthocyanins 234-245 C-X-C motif chemokine ligand 8 Homo sapiens 20-25 27933092-6 2016 The decrease in the CXCL8 level was negatively correlated with the increase in the how-density lipoprotein-cholesterol (HDL-C) level and was positively correlated with the decrease in the soluble P-selectin (sP-selectin) level in the anthocyanin group. Anthocyanins 234-245 selectin P Homo sapiens 196-206 27933092-7 2016 In addition, a positive correlation was observed between the decreases in the CXCL12 and tumornecrosis factor-alpha (TNF-alpha) levels after anthocyanin supplementation. Anthocyanins 141-152 tumor necrosis factor Homo sapiens 89-115 27933092-7 2016 In addition, a positive correlation was observed between the decreases in the CXCL12 and tumornecrosis factor-alpha (TNF-alpha) levels after anthocyanin supplementation. Anthocyanins 141-152 tumor necrosis factor Homo sapiens 117-126 27920784-0 2016 The Arabidopsis ANGUSTIFOLIA3-YODA Gene Cascade Induces Anthocyanin Accumulation by Regulating Sucrose Levels. Anthocyanins 56-67 SSXT family protein Arabidopsis thaliana 16-29 27920784-0 2016 The Arabidopsis ANGUSTIFOLIA3-YODA Gene Cascade Induces Anthocyanin Accumulation by Regulating Sucrose Levels. Anthocyanins 56-67 Protein kinase superfamily protein Arabidopsis thaliana 30-34 27920784-4 2016 Recently, an AN3-CONSTITUTIVE PHOTOMORPHOGENIC 1 gene cascade has been reported to regulate the light signaling-mediated anthocyanin accumulation. Anthocyanins 121-132 SSXT family protein Arabidopsis thaliana 13-16 27920784-5 2016 Target gene analysis indicates that AN3 is associated with the YODA (YDA) promoter, a mitogen-activated protein kinase kinase kinase, in vivo for inducing anthocyanin accumulation. Anthocyanins 155-166 SSXT family protein Arabidopsis thaliana 36-39 27920784-5 2016 Target gene analysis indicates that AN3 is associated with the YODA (YDA) promoter, a mitogen-activated protein kinase kinase kinase, in vivo for inducing anthocyanin accumulation. Anthocyanins 155-166 Protein kinase superfamily protein Arabidopsis thaliana 63-67 27920784-7 2016 YDA mutation can also suppress the decrease in an3-4 anthocyanin accumulation. Anthocyanins 53-64 SSXT family protein Arabidopsis thaliana 47-50 27920784-8 2016 Further analysis indicates that the mutations of AN3 and YDA disrupt the normal Suc levels because of the changes of invertase activity in mutants of an3 or yda, which in turn induces the alterations of anthocyanin accumulation in mutants of an3 or yda via unknown regulatory mechanisms. Anthocyanins 203-214 SSXT family protein Arabidopsis thaliana 49-52 27920784-8 2016 Further analysis indicates that the mutations of AN3 and YDA disrupt the normal Suc levels because of the changes of invertase activity in mutants of an3 or yda, which in turn induces the alterations of anthocyanin accumulation in mutants of an3 or yda via unknown regulatory mechanisms. Anthocyanins 203-214 SSXT family protein Arabidopsis thaliana 150-153 27920784-8 2016 Further analysis indicates that the mutations of AN3 and YDA disrupt the normal Suc levels because of the changes of invertase activity in mutants of an3 or yda, which in turn induces the alterations of anthocyanin accumulation in mutants of an3 or yda via unknown regulatory mechanisms. Anthocyanins 203-214 SSXT family protein Arabidopsis thaliana 242-245 27879624-8 2016 One MYB gene, LhMYB12-Lat, was identified as a key transcription factor determining the distribution of anthocyanins in Asiatic hybrid lily ovaries. Anthocyanins 104-116 MYB proto-oncogene, transcription factor Homo sapiens 4-7 27879624-8 2016 One MYB gene, LhMYB12-Lat, was identified as a key transcription factor determining the distribution of anthocyanins in Asiatic hybrid lily ovaries. Anthocyanins 104-116 linker for activation of T cells Homo sapiens 22-25 27821173-9 2016 Most importantly, anthocyanins increased glutathione (GSH and GSSG) levels and stimulated the endogenous antioxidant system, including Nrf2 and heme oxygenase-1 (HO-1), against glutamate-induced oxidative stress. Anthocyanins 18-30 NFE2 like bZIP transcription factor 2 Rattus norvegicus 135-139 27821173-9 2016 Most importantly, anthocyanins increased glutathione (GSH and GSSG) levels and stimulated the endogenous antioxidant system, including Nrf2 and heme oxygenase-1 (HO-1), against glutamate-induced oxidative stress. Anthocyanins 18-30 heme oxygenase 1 Rattus norvegicus 144-160 27821173-13 2016 Our work demonstrates that glutamate is toxic to the developing rat brain and that anthocyanins can minimize the severity of glutamate-induced neurotoxicity in an AMPK-dependent manner. Anthocyanins 83-95 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 163-167 27046632-4 2016 TTG2 mutants lack the pigmentation found in wild-type seeds, but produce other flavonoid compounds, such as anthocyanins in the shoot, suggesting that TTG2 regulates genes in the PA biosynthetic branch of the flavonoid pathway. Anthocyanins 108-120 WRKY family transcription factor family protein Arabidopsis thaliana 0-4 27867356-2 2016 Cyanidin-3-O-glucoside (C3G), an anthocyanin antioxidant, is reported to have protective effects on many organs. Anthocyanins 33-44 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 24-27 27211666-1 2016 The objective of this study was to evaluate different antioxidants for anthocyanin (ACY) retention in vitamin C fortified cranberry juice and assess its quality. Anthocyanins 84-87 DDB1 and CUL4 associated factor 7 Homo sapiens 71-82 27324255-0 2016 Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-alpha stimulated proinflammatory environment. Anthocyanins 21-33 tumor necrosis factor Homo sapiens 147-156 27324255-4 2016 ACN-RF reduced THP-1 adhesion to HUVECs with a maximum effect at 10 mug/mL (-33%). Anthocyanins 0-3 GLI family zinc finger 2 Homo sapiens 15-20 27038533-4 2016 In this review, we summarize the proposed mechanisms of direct or indirect actions of anthocyanins within cardiac cells with the special emphasis on recently discovered their pharmacological effects on mitochondria in cardioprotection: reduction of cytosolic cytochrome c preventing apoptosis and sustainment of electron transfer between NADH dehydrogenase and cytochrome c supporting oxidative phosphorylation in ischemia-damaged mitochondria. Anthocyanins 86-98 cytochrome c, somatic Homo sapiens 259-271 27522965-6 2016 The immunoblotting results showed that anthocyanins reduced the level of the oxidative stress kinase phospho-c-Jun N-terminal Kinase 1 (p-JNK). Anthocyanins 39-51 mitogen-activated protein kinase 8 Mus musculus 138-141 27522965-7 2016 The immunoblotting and morphological results showed that anthocyanins treatment significantly reduced LPS-induced-ROS-mediated neuroinflammation through inhibition of various inflammatory mediators, such as IL-1beta, TNF-alpha and the transcription factor NF-kB. Anthocyanins 57-69 interleukin 1 beta Mus musculus 207-215 27522965-7 2016 The immunoblotting and morphological results showed that anthocyanins treatment significantly reduced LPS-induced-ROS-mediated neuroinflammation through inhibition of various inflammatory mediators, such as IL-1beta, TNF-alpha and the transcription factor NF-kB. Anthocyanins 57-69 tumor necrosis factor Mus musculus 217-226 27522965-8 2016 Anthocyanins treatment also reduced activated astrocytes and microglia in the cortex of LPS-injected mice, as indicated by reductions in GFAP and Iba-1, respectively. Anthocyanins 0-12 glial fibrillary acidic protein Mus musculus 137-141 27522965-8 2016 Anthocyanins treatment also reduced activated astrocytes and microglia in the cortex of LPS-injected mice, as indicated by reductions in GFAP and Iba-1, respectively. Anthocyanins 0-12 induction of brown adipocytes 1 Mus musculus 146-151 27522965-9 2016 Anthocyanins also prevent overexpression of various apoptotic markers, i.e., Bax, cytosolic cytochrome C, cleaved caspase-3 and PARP-1. Anthocyanins 0-12 BCL2-associated X protein Mus musculus 77-80 27522965-9 2016 Anthocyanins also prevent overexpression of various apoptotic markers, i.e., Bax, cytosolic cytochrome C, cleaved caspase-3 and PARP-1. Anthocyanins 0-12 poly (ADP-ribose) polymerase family, member 1 Mus musculus 128-134 27038533-4 2016 In this review, we summarize the proposed mechanisms of direct or indirect actions of anthocyanins within cardiac cells with the special emphasis on recently discovered their pharmacological effects on mitochondria in cardioprotection: reduction of cytosolic cytochrome c preventing apoptosis and sustainment of electron transfer between NADH dehydrogenase and cytochrome c supporting oxidative phosphorylation in ischemia-damaged mitochondria. Anthocyanins 86-98 cytochrome c, somatic Homo sapiens 361-373 27562381-0 2016 Drastic anthocyanin increase in response to PAP1 overexpression in fls1 knockout mutant confers enhanced osmotic stress tolerance in Arabidopsis thaliana. Anthocyanins 8-19 production of anthocyanin pigment 1 Arabidopsis thaliana 44-48 27562381-0 2016 Drastic anthocyanin increase in response to PAP1 overexpression in fls1 knockout mutant confers enhanced osmotic stress tolerance in Arabidopsis thaliana. Anthocyanins 8-19 flavonol synthase 1 Arabidopsis thaliana 67-71 27562381-1 2016 KEY MESSAGE : pap1 - D/fls1ko double mutant plants that produce substantial amounts of anthocyanin show tolerance to abiotic stress. Anthocyanins 87-98 production of anthocyanin pigment 1 Arabidopsis thaliana 14-18 27562381-4 2016 The MYB gene Production of Anthocyanin Pigment 1 (PAP1) plays a particularly important role in anthocyanin accumulation. Anthocyanins 95-106 production of anthocyanin pigment 1 Arabidopsis thaliana 13-48 27562381-4 2016 The MYB gene Production of Anthocyanin Pigment 1 (PAP1) plays a particularly important role in anthocyanin accumulation. Anthocyanins 95-106 production of anthocyanin pigment 1 Arabidopsis thaliana 50-54 27562381-5 2016 PAP1 expression in many plant systems strongly increases anthocyanin levels, resulting in a dark purple color in many plant organs. Anthocyanins 57-68 production of anthocyanin pigment 1 Arabidopsis thaliana 0-4 27562381-8 2016 The pap1-D/fls1ko mutants accumulated higher anthocyanin levels than pap1-D plants in both control and sucrose-treated conditions. Anthocyanins 45-56 production of anthocyanin pigment 1 Arabidopsis thaliana 4-8 27404131-7 2016 Expression analysis with qRT-PCR demonstrated that the transcript levels of JA-regulated anthocyanin biosynthetic genes, such as MdDFR, MdUF3GT, MdF3H and MdCHS, were markedly up-regulated in the MdMYC2 overexpressing calli and down-regulated in the suppressing calli compared with the WT control. Anthocyanins 89-100 naringenin,2-oxoglutarate 3-dioxygenase-like Malus domestica 145-150 27811015-0 2016 MYB75 Phosphorylation by MPK4 Is Required for Light-Induced Anthocyanin Accumulation in Arabidopsis. Anthocyanins 60-71 production of anthocyanin pigment 1 Arabidopsis thaliana 0-5 27811015-0 2016 MYB75 Phosphorylation by MPK4 Is Required for Light-Induced Anthocyanin Accumulation in Arabidopsis. Anthocyanins 60-71 MAP kinase 4 Arabidopsis thaliana 25-29 27811015-3 2016 In Arabidopsis thaliana, the accumulation of photoprotective anthocyanin pigments is light dependent, and the R2R3 MYB transcription factor MYB75/PAP1 regulates anthocyanin accumulation. Anthocyanins 61-72 production of anthocyanin pigment 1 Arabidopsis thaliana 140-145 27811015-3 2016 In Arabidopsis thaliana, the accumulation of photoprotective anthocyanin pigments is light dependent, and the R2R3 MYB transcription factor MYB75/PAP1 regulates anthocyanin accumulation. Anthocyanins 61-72 phosphatidic acid phosphatase 1 Arabidopsis thaliana 146-150 27811015-3 2016 In Arabidopsis thaliana, the accumulation of photoprotective anthocyanin pigments is light dependent, and the R2R3 MYB transcription factor MYB75/PAP1 regulates anthocyanin accumulation. Anthocyanins 161-172 production of anthocyanin pigment 1 Arabidopsis thaliana 140-145 27811015-3 2016 In Arabidopsis thaliana, the accumulation of photoprotective anthocyanin pigments is light dependent, and the R2R3 MYB transcription factor MYB75/PAP1 regulates anthocyanin accumulation. Anthocyanins 161-172 phosphatidic acid phosphatase 1 Arabidopsis thaliana 146-150 27811015-6 2016 MPK4 can be activated in response to light and is involved in the light-induced accumulation of anthocyanins. Anthocyanins 96-108 MAP kinase 4 Arabidopsis thaliana 0-4 27811015-7 2016 We show that MPK4 phosphorylation of MYB75 increases its stability and is essential for light-induced anthocyanin accumulation. Anthocyanins 102-113 MAP kinase 4 Arabidopsis thaliana 13-17 27173557-0 2016 Complexation of bovine beta-lactoglobulin with malvidin-3-O-glucoside and its effect on the stability of grape skin anthocyanin extracts. Anthocyanins 116-127 beta-lactoglobulin Bos taurus 23-41 27811015-7 2016 We show that MPK4 phosphorylation of MYB75 increases its stability and is essential for light-induced anthocyanin accumulation. Anthocyanins 102-113 production of anthocyanin pigment 1 Arabidopsis thaliana 37-42 27717450-3 2016 The anthocyanin content detected in transgenic plants expressing the anthocyanin regulatory transcription factors (B-Peru+mPAP1 or RsMYB1) was higher than that in NT plants. Anthocyanins 4-15 retinitis pigmentosa 9 (human) Mus musculus 122-127 27717450-3 2016 The anthocyanin content detected in transgenic plants expressing the anthocyanin regulatory transcription factors (B-Peru+mPAP1 or RsMYB1) was higher than that in NT plants. Anthocyanins 69-80 retinitis pigmentosa 9 (human) Mus musculus 122-127 27173557-1 2016 The binding interaction between bovine beta-lactoglobulin and malvidin-3-O-glucoside (MG), the major anthocyanin in grape skin anthocyanin extracts (GSAE), was studied at pH 6.3 using fluorescence, Fourier transform infrared and circular dichroism spectroscopy. Anthocyanins 101-112 beta-lactoglobulin Bos taurus 39-57 27173557-1 2016 The binding interaction between bovine beta-lactoglobulin and malvidin-3-O-glucoside (MG), the major anthocyanin in grape skin anthocyanin extracts (GSAE), was studied at pH 6.3 using fluorescence, Fourier transform infrared and circular dichroism spectroscopy. Anthocyanins 127-138 beta-lactoglobulin Bos taurus 39-57 27790239-3 2016 In this study, we investigated the role of a NAC transcription factor, ANAC032, in the regulation of anthocyanin biosynthesis during stress conditions. Anthocyanins 101-112 NAC domain containing protein 32 Arabidopsis thaliana 71-78 27821173-0 2016 Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, neuroinflammation, and neurodegeneration in postnatal rat brain. Anthocyanins 0-12 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 40-44 27790239-5 2016 Using biochemical, molecular and transgenic approaches, we show that ANAC032 represses anthocyanin biosynthesis in response to sucrose treatment, HL and oxidative stress. Anthocyanins 87-98 NAC domain containing protein 32 Arabidopsis thaliana 69-76 27790239-6 2016 ANAC032 was found to negatively affect anthocyanin accumulation and the expression of anthocyanin biosynthesis (DFR, ANS/LDOX) and positive regulatory (TT8) genes as demonstrated in overexpression line (35S:ANAC032) compared to wild-type under HL stress. Anthocyanins 39-50 NAC domain containing protein 32 Arabidopsis thaliana 0-7 27790239-6 2016 ANAC032 was found to negatively affect anthocyanin accumulation and the expression of anthocyanin biosynthesis (DFR, ANS/LDOX) and positive regulatory (TT8) genes as demonstrated in overexpression line (35S:ANAC032) compared to wild-type under HL stress. Anthocyanins 86-97 NAC domain containing protein 32 Arabidopsis thaliana 0-7 27790239-8 2016 The negative impact of ANAC032 on the expression of DFR, ANS/LDOX and TT8 was found to be correlated with the altered expression of negative regulators of anthocyanin biosynthesis, AtMYBL2 and SPL9. Anthocyanins 155-166 NAC domain containing protein 32 Arabidopsis thaliana 23-30 27790239-8 2016 The negative impact of ANAC032 on the expression of DFR, ANS/LDOX and TT8 was found to be correlated with the altered expression of negative regulators of anthocyanin biosynthesis, AtMYBL2 and SPL9. Anthocyanins 155-166 dihydroflavonol 4-reductase Arabidopsis thaliana 52-55 27790239-8 2016 The negative impact of ANAC032 on the expression of DFR, ANS/LDOX and TT8 was found to be correlated with the altered expression of negative regulators of anthocyanin biosynthesis, AtMYBL2 and SPL9. Anthocyanins 155-166 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 70-73 27790239-9 2016 In addition to this, ANAC032 also repressed the MeJA- and ABA-induced anthocyanin biosynthesis. Anthocyanins 70-81 NAC domain containing protein 32 Arabidopsis thaliana 21-28 27790239-12 2016 Our results suggest that ANAC032 functions as a negative regulator of anthocyanin biosynthesis in Arabidopsis thaliana during stress conditions. Anthocyanins 70-81 NAC domain containing protein 32 Arabidopsis thaliana 25-32 27450422-8 2016 Together, these results delineate the HY5-MIR858a-MYBL2 loop as a cellular mechanism for modulating anthocyanin biosynthesis, suggesting that integration of transcriptional and posttranscriptional regulation is critical for governing proper anthocyanin accumulation in response to light and other environmental factors. Anthocyanins 241-252 MYB-like 2 Arabidopsis thaliana 50-55 27706214-9 2016 Collectively, these results proved the regulatory function of the Ant2 gene in anthocyanin biosynthesis in barley grain pericarp. Anthocyanins 79-90 solute carrier family 25 member 6 Homo sapiens 66-70 27143545-3 2016 Both PIA2 and PIF3 are known to be positive regulators of anthocyanin accumulation in Arabidopsis seedlings under far-red conditions. Anthocyanins 58-69 Ankyrin repeat family protein Arabidopsis thaliana 5-9 27450422-0 2016 Repression of MYBL2 by Both microRNA858a and HY5 Leads to the Activation of Anthocyanin Biosynthetic Pathway in Arabidopsis. Anthocyanins 76-87 MYB-like 2 Arabidopsis thaliana 14-19 27450422-0 2016 Repression of MYBL2 by Both microRNA858a and HY5 Leads to the Activation of Anthocyanin Biosynthetic Pathway in Arabidopsis. Anthocyanins 76-87 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 45-48 27450422-3 2016 Here, we demonstrate that miR858a is a positive regulator of anthocyanin biosynthesis in Arabidopsis seedlings. Anthocyanins 61-72 MIR858a Arabidopsis thaliana 26-33 27450422-4 2016 Overexpression of miR858a enhances the accumulation of anthocyanins, whereas the reduced miR858a activity results in low levels of anthocyanins in STTM858 transgenic plants. Anthocyanins 55-67 MIR858a Arabidopsis thaliana 18-25 27450422-4 2016 Overexpression of miR858a enhances the accumulation of anthocyanins, whereas the reduced miR858a activity results in low levels of anthocyanins in STTM858 transgenic plants. Anthocyanins 131-143 MIR858a Arabidopsis thaliana 89-96 27450422-5 2016 We found that miR858a inhibits the expression of MYBL2, a key negative regulator of anthocyanin biosynthesis, by translational repression. Anthocyanins 84-95 MIR858a Arabidopsis thaliana 14-21 27450422-5 2016 We found that miR858a inhibits the expression of MYBL2, a key negative regulator of anthocyanin biosynthesis, by translational repression. Anthocyanins 84-95 MYB-like 2 Arabidopsis thaliana 49-54 27450422-8 2016 Together, these results delineate the HY5-MIR858a-MYBL2 loop as a cellular mechanism for modulating anthocyanin biosynthesis, suggesting that integration of transcriptional and posttranscriptional regulation is critical for governing proper anthocyanin accumulation in response to light and other environmental factors. Anthocyanins 100-111 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 38-41 27450422-8 2016 Together, these results delineate the HY5-MIR858a-MYBL2 loop as a cellular mechanism for modulating anthocyanin biosynthesis, suggesting that integration of transcriptional and posttranscriptional regulation is critical for governing proper anthocyanin accumulation in response to light and other environmental factors. Anthocyanins 100-111 MIR858a Arabidopsis thaliana 42-49 27450422-8 2016 Together, these results delineate the HY5-MIR858a-MYBL2 loop as a cellular mechanism for modulating anthocyanin biosynthesis, suggesting that integration of transcriptional and posttranscriptional regulation is critical for governing proper anthocyanin accumulation in response to light and other environmental factors. Anthocyanins 100-111 MYB-like 2 Arabidopsis thaliana 50-55 27450422-8 2016 Together, these results delineate the HY5-MIR858a-MYBL2 loop as a cellular mechanism for modulating anthocyanin biosynthesis, suggesting that integration of transcriptional and posttranscriptional regulation is critical for governing proper anthocyanin accumulation in response to light and other environmental factors. Anthocyanins 241-252 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 38-41 27450422-8 2016 Together, these results delineate the HY5-MIR858a-MYBL2 loop as a cellular mechanism for modulating anthocyanin biosynthesis, suggesting that integration of transcriptional and posttranscriptional regulation is critical for governing proper anthocyanin accumulation in response to light and other environmental factors. Anthocyanins 241-252 MIR858a Arabidopsis thaliana 42-49 27790239-0 2016 The Arabidopsis Transcription Factor ANAC032 Represses Anthocyanin Biosynthesis in Response to High Sucrose and Oxidative and Abiotic Stresses. Anthocyanins 55-66 NAC domain containing protein 32 Arabidopsis thaliana 37-44 27143545-3 2016 Both PIA2 and PIF3 are known to be positive regulators of anthocyanin accumulation in Arabidopsis seedlings under far-red conditions. Anthocyanins 58-69 phytochrome interacting factor 3 Arabidopsis thaliana 14-18 27273756-3 2016 Here, we report the identification of a mutant ugt72b1 showing aggravated and ectopic lignification in floral stems along with arrested growth and anthocyanin accumulation. Anthocyanins 147-158 UDP-Glycosyltransferase superfamily protein Arabidopsis thaliana 47-54 27591835-2 2016 It has been proposed that commonly consumed anthocyanins, such as cyandin-3-O-beta-glucoside (C3G), confer cellular protection by stimulating biosynthesis of glutathione (GSH), an endogenous antioxidant. Anthocyanins 44-56 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 66-92 27591835-2 2016 It has been proposed that commonly consumed anthocyanins, such as cyandin-3-O-beta-glucoside (C3G), confer cellular protection by stimulating biosynthesis of glutathione (GSH), an endogenous antioxidant. Anthocyanins 44-56 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 94-97 27690088-0 2016 The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression. Anthocyanins 75-86 Kruppel like factor 6 Homo sapiens 116-120 27657062-6 2016 It has been reported that the natural compound anthocyanin (ACN) has the ability to reduce the risk of cardiovascular disease (CVD). Anthocyanins 60-63 DDB1 and CUL4 associated factor 7 Homo sapiens 47-58 27580020-0 2016 Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cells and db/db mice. Anthocyanins 9-20 insulin Homo sapiens 41-48 27580020-0 2016 Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cells and db/db mice. Anthocyanins 9-20 AKT serine/threonine kinase 1 Homo sapiens 79-82 27580020-1 2016 This study evaluated the capacity of mulberry anthocyanin extract (MAE) on insulin resistance amelioration in HepG2 cells induced by high glucose and palmitic acid and diabetes-related metabolic changes in type 2 diabetic mice. Anthocyanins 46-57 insulin Homo sapiens 75-82 27143545-10 2016 In addition, decreased anthocyanin accumulation in pia2 knockout plant seedlings was not rescued by overexpression of the alpha-helix breaking mutant in transgenic plants under far-red conditions. Anthocyanins 23-34 Ankyrin repeat family protein Arabidopsis thaliana 51-55 27219053-3 2016 Leucoanthocyanidin dioxygenase (LDOX, EC 1.14.11.19) is one of three dioxygenases in the flavonoid pathway that catalyzes the formation of anthocyanidins from leucoanthocyanidins. Anthocyanins 139-153 leucoanthocyanidin dioxygenase Arabidopsis thaliana 0-30 27219053-3 2016 Leucoanthocyanidin dioxygenase (LDOX, EC 1.14.11.19) is one of three dioxygenases in the flavonoid pathway that catalyzes the formation of anthocyanidins from leucoanthocyanidins. Anthocyanins 139-153 leucoanthocyanidin dioxygenase Arabidopsis thaliana 32-36 27219053-0 2016 The Reaumuria trigyna leucoanthocyanidin dioxygenase (RtLDOX) gene complements anthocyanidin synthesis and increases the salt tolerance potential of a transgenic Arabidopsis LDOX mutant. Anthocyanins 27-40 leucoanthocyanidin dioxygenase Arabidopsis thaliana 56-60 27219053-3 2016 Leucoanthocyanidin dioxygenase (LDOX, EC 1.14.11.19) is one of three dioxygenases in the flavonoid pathway that catalyzes the formation of anthocyanidins from leucoanthocyanidins. Anthocyanins 159-178 leucoanthocyanidin dioxygenase Arabidopsis thaliana 0-30 27219053-3 2016 Leucoanthocyanidin dioxygenase (LDOX, EC 1.14.11.19) is one of three dioxygenases in the flavonoid pathway that catalyzes the formation of anthocyanidins from leucoanthocyanidins. Anthocyanins 159-178 leucoanthocyanidin dioxygenase Arabidopsis thaliana 32-36 27219053-5 2016 R. trigyna LDOX can complement the Arabidopsis LDOX mutant transparent testa11 (tt11-11), which has reduced proanthocyanin (PA) and anthocyanin levels in seeds, to accumulate these two compounds. Anthocyanins 111-122 leucoanthocyanidin dioxygenase Arabidopsis thaliana 11-15 27314273-0 2016 Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation. Anthocyanins 6-18 caspase 3 Homo sapiens 88-97 27259636-0 2016 Overexpression of PtrMYB119, a R2R3-MYB transcription factor from Populus trichocarpa, promotes anthocyanin production in hybrid poplar. Anthocyanins 96-107 production of anthocyanin pigment 1 Arabidopsis thaliana 108-118 27259636-2 2016 We found an MYB transcription factor (PtrMYB119) from Populus trichocarpa that positively regulates anthocyanin production when expressed under the control of the CaMV 35S promoter in transgenic Arabidopsis Amino acid sequence analysis revealed that PtrMYB119 is highly homologous to Arabidopsis PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT1), a well-known transcriptional activator of anthocyanin biosynthesis. Anthocyanins 100-111 production of anthocyanin pigment 1 Arabidopsis thaliana 112-122 27259636-2 2016 We found an MYB transcription factor (PtrMYB119) from Populus trichocarpa that positively regulates anthocyanin production when expressed under the control of the CaMV 35S promoter in transgenic Arabidopsis Amino acid sequence analysis revealed that PtrMYB119 is highly homologous to Arabidopsis PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT1), a well-known transcriptional activator of anthocyanin biosynthesis. Anthocyanins 100-111 production of anthocyanin pigment 1 Arabidopsis thaliana 296-300 27259636-2 2016 We found an MYB transcription factor (PtrMYB119) from Populus trichocarpa that positively regulates anthocyanin production when expressed under the control of the CaMV 35S promoter in transgenic Arabidopsis Amino acid sequence analysis revealed that PtrMYB119 is highly homologous to Arabidopsis PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT1), a well-known transcriptional activator of anthocyanin biosynthesis. Anthocyanins 100-111 production of anthocyanin pigment 1 Arabidopsis thaliana 302-336 27259636-2 2016 We found an MYB transcription factor (PtrMYB119) from Populus trichocarpa that positively regulates anthocyanin production when expressed under the control of the CaMV 35S promoter in transgenic Arabidopsis Amino acid sequence analysis revealed that PtrMYB119 is highly homologous to Arabidopsis PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT1), a well-known transcriptional activator of anthocyanin biosynthesis. Anthocyanins 381-392 production of anthocyanin pigment 1 Arabidopsis thaliana 112-122 27560976-7 2016 Overall, our findings provide new insights into the mechanism of the glucose sensor HXK1 modulation of anthocyanin accumulation, which occur by directly regulating the anthocyanin-related bHLH TFs in response to a glucose signal in plants. Anthocyanins 103-114 hexokinase-1-like Malus domestica 84-88 27560976-7 2016 Overall, our findings provide new insights into the mechanism of the glucose sensor HXK1 modulation of anthocyanin accumulation, which occur by directly regulating the anthocyanin-related bHLH TFs in response to a glucose signal in plants. Anthocyanins 168-179 hexokinase-1-like Malus domestica 84-88 27314273-0 2016 Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation. Anthocyanins 6-18 cyclin dependent kinase inhibitor 1A Homo sapiens 113-116 27314273-3 2016 In the present study, the effect of a standardized anthocyanin (ACN)-rich extract on proliferation, apoptosis and cell cycle in the Caco-2 human colorectal cancer cell line was evaluated by trypan blue and clonogenic assays and western blot analysis of cleaved caspase-3 and p21Waf/Cif1. Anthocyanins 51-62 caspase 3 Homo sapiens 261-270 27314273-3 2016 In the present study, the effect of a standardized anthocyanin (ACN)-rich extract on proliferation, apoptosis and cell cycle in the Caco-2 human colorectal cancer cell line was evaluated by trypan blue and clonogenic assays and western blot analysis of cleaved caspase-3 and p21Waf/Cif1. Anthocyanins 64-67 caspase 3 Homo sapiens 261-270 27314273-4 2016 The results of the current study demonstrated that the ACN extract markedly decreased Caco-2 cell proliferation, induced apoptosis by activating caspase-3 cleavage, and upregulated cyclin-dependent kinase inhibitor 1 (p21Waf/Cif1) expression in a dose dependent manner. Anthocyanins 55-58 caspase 3 Homo sapiens 145-154 27314273-4 2016 The results of the current study demonstrated that the ACN extract markedly decreased Caco-2 cell proliferation, induced apoptosis by activating caspase-3 cleavage, and upregulated cyclin-dependent kinase inhibitor 1 (p21Waf/Cif1) expression in a dose dependent manner. Anthocyanins 55-58 cyclin dependent kinase inhibitor 1A Homo sapiens 181-216 27314273-6 2016 In conclusion, the present study demonstrated that a standardized berry anthocyanin rich extract inhibited proliferation of Caco-2 cells by promoting ROS accumulation, inducing caspase-3 activation, and upregulating the expression of p21Waf/Cif1. Anthocyanins 72-83 caspase 3 Homo sapiens 177-186 27125220-7 2016 BEE1 and GFR were both shown to negatively regulate anthocyanin accumulation by inhibiting anthocyanin synthesis genes via the suppression of the bHLH (TRANSPARENT TESTA8 (TT8) and GLABROUS3 (GL3)) and/or the MYB (PRODUCTION OF ANTHOCYANIN PIGMENTS2 (PAP2)) components of the MBW complex. Anthocyanins 52-63 BR enhanced expression 1 Arabidopsis thaliana 0-4 27125220-7 2016 BEE1 and GFR were both shown to negatively regulate anthocyanin accumulation by inhibiting anthocyanin synthesis genes via the suppression of the bHLH (TRANSPARENT TESTA8 (TT8) and GLABROUS3 (GL3)) and/or the MYB (PRODUCTION OF ANTHOCYANIN PIGMENTS2 (PAP2)) components of the MBW complex. Anthocyanins 52-63 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 172-175 27125220-7 2016 BEE1 and GFR were both shown to negatively regulate anthocyanin accumulation by inhibiting anthocyanin synthesis genes via the suppression of the bHLH (TRANSPARENT TESTA8 (TT8) and GLABROUS3 (GL3)) and/or the MYB (PRODUCTION OF ANTHOCYANIN PIGMENTS2 (PAP2)) components of the MBW complex. Anthocyanins 91-102 BR enhanced expression 1 Arabidopsis thaliana 0-4 27125220-7 2016 BEE1 and GFR were both shown to negatively regulate anthocyanin accumulation by inhibiting anthocyanin synthesis genes via the suppression of the bHLH (TRANSPARENT TESTA8 (TT8) and GLABROUS3 (GL3)) and/or the MYB (PRODUCTION OF ANTHOCYANIN PIGMENTS2 (PAP2)) components of the MBW complex. Anthocyanins 228-239 BR enhanced expression 1 Arabidopsis thaliana 0-4 27089858-5 2016 In addition to confirming a role for CD2 in regulating cuticle formation, the results also revealed that CD2 influences pathways associated with cell wall biology, anthocyanin biosynthesis, plant development, and responses to stress, which complements findings of earlier RNA-Seq experiments. Anthocyanins 164-175 cutin deficient 2 Solanum lycopersicum 105-108 26849180-9 2016 The domain/family annotation and phylogenetic analysis allowed us to infer, by homology, potential functions of the genes encoding MYB, HD-ZIP and bZIP-HY5 transcription factors, as well as WD40 protein, which may be involved in anthocyanin and flavonoid regulation in these species. Anthocyanins 229-240 MYB proto-oncogene, transcription factor Homo sapiens 131-134 27170557-7 2016 Specifically, berry extracts and anthocyanins inhibit the activities of pancreatic alpha-amylase and alpha-glucosidase in the gut lumen, and interact with intestinal sugar transporters, sodium-dependent glucose transporter 1 and GLUT2, to reduce the rate of glucose uptake into the circulation. Anthocyanins 33-45 amylase alpha 2A Homo sapiens 72-96 27170557-7 2016 Specifically, berry extracts and anthocyanins inhibit the activities of pancreatic alpha-amylase and alpha-glucosidase in the gut lumen, and interact with intestinal sugar transporters, sodium-dependent glucose transporter 1 and GLUT2, to reduce the rate of glucose uptake into the circulation. Anthocyanins 33-45 sucrase-isomaltase Homo sapiens 101-118 27170557-7 2016 Specifically, berry extracts and anthocyanins inhibit the activities of pancreatic alpha-amylase and alpha-glucosidase in the gut lumen, and interact with intestinal sugar transporters, sodium-dependent glucose transporter 1 and GLUT2, to reduce the rate of glucose uptake into the circulation. Anthocyanins 33-45 major facilitator superfamily domain containing 4B Homo sapiens 186-224 27170557-7 2016 Specifically, berry extracts and anthocyanins inhibit the activities of pancreatic alpha-amylase and alpha-glucosidase in the gut lumen, and interact with intestinal sugar transporters, sodium-dependent glucose transporter 1 and GLUT2, to reduce the rate of glucose uptake into the circulation. Anthocyanins 33-45 solute carrier family 2 member 2 Homo sapiens 229-234 27312419-1 2016 AIMS: The aim of this research was to determine the hepatoprotective effects of anthocyanins from bilberry extract in rats exposed to carbon tetrachloride (CCl4) by monitoring the parameters of oxidative stress and apoptosis, and by performing the histopathological and morphometric analyses. Anthocyanins 80-92 C-C motif chemokine ligand 4 Rattus norvegicus 156-160 27389008-5 2016 Increased anthocyanin content and acid phosphatase activity, reduced accumulation of reactive oxygen species and downregulated expression of Pi starvation-induced genes including PHR1, WRKY75, AT4, PHT1;2 and PHT1;4 were observed in bik1 plants grown under Pi deficient condition. Anthocyanins 10-21 photolyase 1 Arabidopsis thaliana 179-183 27389008-5 2016 Increased anthocyanin content and acid phosphatase activity, reduced accumulation of reactive oxygen species and downregulated expression of Pi starvation-induced genes including PHR1, WRKY75, AT4, PHT1;2 and PHT1;4 were observed in bik1 plants grown under Pi deficient condition. Anthocyanins 10-21 WRKY DNA-binding protein 75 Arabidopsis thaliana 185-191 27389008-5 2016 Increased anthocyanin content and acid phosphatase activity, reduced accumulation of reactive oxygen species and downregulated expression of Pi starvation-induced genes including PHR1, WRKY75, AT4, PHT1;2 and PHT1;4 were observed in bik1 plants grown under Pi deficient condition. Anthocyanins 10-21 expressed in response to phosphate starvation protein Arabidopsis thaliana 193-196 27031424-9 2016 The results of gene expression analyses suggest that the increment in total anthocyanin content is related to a short term increase in phenylalanine ammonia-lyase (PAL) expression, mediated by a decrease in MYB4A expression. Anthocyanins 76-87 peptidylglycine alpha-amidating monooxygenase Homo sapiens 135-162 27031424-9 2016 The results of gene expression analyses suggest that the increment in total anthocyanin content is related to a short term increase in phenylalanine ammonia-lyase (PAL) expression, mediated by a decrease in MYB4A expression. Anthocyanins 76-87 peptidylglycine alpha-amidating monooxygenase Homo sapiens 164-167 27016448-5 2016 Phenotypes of the pho1 mutant typically associated with Pi deficiency, such as high shoot anthocyanin levels and poor shoot growth, were significantly attenuated by blocking the JA biosynthesis or signaling pathway. Anthocyanins 90-101 phosphate 1 Arabidopsis thaliana 18-22 27338244-10 2016 CONCLUSIONS: We highlight the protective role of genetic variants in PON1 towards cardiovascular risk under high polyphenols and anthocyanins consumption. Anthocyanins 129-141 paraoxonase 1 Homo sapiens 69-73 28330149-3 2016 Results of reverse-transcription-PCR analysis revealed that the expression of RsMYB1 was stable in all transgenic lines and could enhance the expression levels of three key biosynthetic genes (F3H, DFR, and ANS) involved in anthocyanin production. Anthocyanins 224-235 naringenin,2-oxoglutarate 3-dioxygenase Raphanus sativus 193-196 26873533-0 2016 Anthocyanins and their gut metabolites reduce the adhesion of monocyte to TNFalpha-activated endothelial cells at physiologically relevant concentrations. Anthocyanins 0-12 tumor necrosis factor Homo sapiens 74-82 26873533-3 2016 The aim of this work was to investigate the effect of plasma anthocyanins and their metabolites on the adhesion of monocytes to TNFalpha-activated endothelial cells and on the expression of genes encoding cell adhesion molecules. Anthocyanins 61-73 tumor necrosis factor Homo sapiens 128-136 26969805-4 2016 In induced myogenic cells, the lowest and middle anthocyanidin doses caused significantly greater expression of myoD after 24h of treatment compared to control. Anthocyanins 49-62 myoblast determination protein 1 homolog 1 Oncorhynchus mykiss 112-116 26969805-6 2016 Similarly, the pax7/myoD ratio was significantly lower in cells exposed to the lowest anthocyanidin doses during 24h compared to control. Anthocyanins 86-99 myoblast determination protein 1 homolog 1 Oncorhynchus mykiss 20-24 26969805-9 2016 Further, the pax7/myoD ratio was significantly lower in cells exposed to either anthocyanidin doses at both sampling time. Anthocyanins 80-93 myoblast determination protein 1 homolog 1 Oncorhynchus mykiss 18-22 26990404-4 2016 Whereas fls1-3 mutants accumulated higher anthocyanin levels, FLS1-OX seedlings had lower levels than those of the wild-type. Anthocyanins 42-53 flavonol synthase 1 Arabidopsis thaliana 8-12 26990404-7 2016 Taken together, FLS1 can be manipulated (i.e., silenced or overexpressed) to redirect the flavonoid biosynthetic pathway toward anthocyanin production without negative effects on plant growth and development. Anthocyanins 128-139 flavonol synthase 1 Arabidopsis thaliana 16-20 26985659-5 2016 Through a high-throughput screening approach, we previously identified numerous anthocyanins that exert activity in HER2-positive human breast cancer cell lines. Anthocyanins 80-92 erb-b2 receptor tyrosine kinase 2 Homo sapiens 116-120 26985659-6 2016 The present study aimed to evaluate the anti-tumor properties of anthocyanins against parental HER2-positive cells and derivative trastuzumab-resistant cells in vitro and in vivo. Anthocyanins 65-77 erb-b2 receptor tyrosine kinase 2 Homo sapiens 95-99 26883224-9 2016 Moreover, this cka4-2 mutant accumulates higher anthocyanin in the aerial part and shows an increased expression of anthocyanin biosynthetic genes, suggesting a novel role of CK2 in modulating anthocyanin biosynthesis. Anthocyanins 48-59 Protein kinase superfamily protein Arabidopsis thaliana 15-19 26883224-9 2016 Moreover, this cka4-2 mutant accumulates higher anthocyanin in the aerial part and shows an increased expression of anthocyanin biosynthetic genes, suggesting a novel role of CK2 in modulating anthocyanin biosynthesis. Anthocyanins 116-127 Protein kinase superfamily protein Arabidopsis thaliana 15-19 26883224-9 2016 Moreover, this cka4-2 mutant accumulates higher anthocyanin in the aerial part and shows an increased expression of anthocyanin biosynthetic genes, suggesting a novel role of CK2 in modulating anthocyanin biosynthesis. Anthocyanins 116-127 Protein kinase superfamily protein Arabidopsis thaliana 15-19 26821071-0 2016 Anthocyanidins but not anthocyanins inhibit P-glycoprotein-mediated calcein extrusion - possible implication for orally administered drugs. Anthocyanins 0-14 ATP binding cassette subfamily B member 1 Homo sapiens 44-58 26821071-6 2016 Here, we found that anthocyanidins (aglycons) but not anthocyanins (glycosides) can significantly inhibit P-gp up to 60% of positive control, verapamil. Anthocyanins 20-34 ATP binding cassette subfamily B member 1 Homo sapiens 106-110 26663436-0 2016 Anthocyanin contents in the seed coat of black soya bean and their anti-human tyrosinase activity and antioxidative activity. Anthocyanins 0-11 tyrosinase Homo sapiens 78-88 26663436-8 2016 Three anthocyanin compounds were found in all the extracts from SCBS, and the analysis of HPLC and LC/MS/MS indicated that they were C3G, delphinidin-3-O-glucoside (D3G) and peonidin-3-O-glucoside (P3G). Anthocyanins 6-17 Rap guanine nucleotide exchange factor 1 Homo sapiens 133-136 27248141-0 2016 Intronic Sequence Regulates Sugar-Dependent Expression of Arabidopsis thaliana Production of Anthocyanin Pigment-1/MYB75. Anthocyanins 93-104 production of anthocyanin pigment 1 Arabidopsis thaliana 115-120 27152519-1 2016 BACKGROUND/AIMS: We previously demonstrated that anthocyanin-rich bilberry extract (ARBE) inhibits IFN-gamma-induced signalling and downstream effects in human monocytic cells and ameliorates disease activity in ulcerative colitis (UC) patients. Anthocyanins 49-60 interferon gamma Homo sapiens 99-108 26854848-0 2016 DELLA Proteins Promote Anthocyanin Biosynthesis via Sequestering MYBL2 and JAZ Suppressors of the MYB/bHLH/WD40 Complex in Arabidopsis thaliana. Anthocyanins 23-34 MYB-like 2 Arabidopsis thaliana 65-70 26854848-5 2016 Here, we found that MYBL2 and JAZs mediate gibberellic acid-inhibited anthocyanin biosynthesis in Arabidopsis. Anthocyanins 70-81 MYB-like 2 Arabidopsis thaliana 20-25 26854848-6 2016 Competitive pull-down and dual-luciferase assays showed that DELLA proteins directly sequester MYBL2 and JAZ repressors, leading to the release of bHLH/MYB subunits and subsequently to the formation of active MBW complex, which then activates the anthocyanin biosynthetic pathway. Anthocyanins 247-258 MYB-like 2 Arabidopsis thaliana 95-100 26854848-7 2016 The JAZ-DELLA-MYBL2 module also plays an important role in abiotic stress-induced anthocyanin biosynthesis. Anthocyanins 82-93 MYB-like 2 Arabidopsis thaliana 14-19 26854848-9 2016 Altogether, our data reveal that DELLA-promoted anthocyanin biosynthesis is mediated at least in part by MYBL2 and JAZ regulatory proteins, providing new insights into the coordinated regulation of plant growth and defense through metabolic pathway regulation. Anthocyanins 48-59 MYB-like 2 Arabidopsis thaliana 105-110 26842771-7 2016 Strawberry intake reduced the insulin demand to manage postmeal glucose in obese individuals with IR, which was related to plasma anthocyanin/pelargonidin concentrations. Anthocyanins 130-141 insulin Homo sapiens 30-37 30133211-0 2016 [Study on Mulberry Anthocyanins Induced Autophagy and Apoptosis of Human Gastric Cancer SGC-7901 Cell Autophagy]. Anthocyanins 19-31 sarcoglycan beta Homo sapiens 88-91 30133211-1 2016 Objective: To observe the effect and mechanism of mulberry anthocyanins on autophagy and apoptosis in SGC-7901 cells. Anthocyanins 59-71 sarcoglycan beta Homo sapiens 102-105 30133211-2 2016 Methods: MTT assay was used to detected mulberry anthocyanins on proliferation of SGC-7901 cells; flow cytometry analysis was used to detected the influence of mulberry anthocyanins on cell apoptosis; Hoechst 33342 / PI live cell staining was used to observe the morphological changes of apoptotic nuclei; transmission electron microscope( TEM) was used to observe the ultrastructural changes of the SGC-7901 cells. Anthocyanins 49-61 sarcoglycan beta Homo sapiens 82-85 30133211-4 2016 Results: Mulberry anthocyanins can inhibit the proliferation of SGC-7901 cells, and mulberry anthocyanins can induce cells apoptosis by the results of flow cytometry and Hoechst33342 / PI double staining. Anthocyanins 18-30 sarcoglycan beta Homo sapiens 64-67 30133211-5 2016 TEM observation results indicated that mulberry anthocyanins intervented SGC-7901 cells induced autophagy. Anthocyanins 48-60 sarcoglycan beta Homo sapiens 73-76 30133211-6 2016 The result of Western blot confirmed that mulberry anthocyanins can increase the ratio of LC3-II /LC3-I,BAX / BCL-2 ratio and the expression of Caspase-8,Beclin1 of SGC-7901 cells. Anthocyanins 51-63 microtubule associated protein 1 light chain 3 alpha Homo sapiens 90-93 30133211-6 2016 The result of Western blot confirmed that mulberry anthocyanins can increase the ratio of LC3-II /LC3-I,BAX / BCL-2 ratio and the expression of Caspase-8,Beclin1 of SGC-7901 cells. Anthocyanins 51-63 BCL2 associated X, apoptosis regulator Homo sapiens 98-107 30133211-6 2016 The result of Western blot confirmed that mulberry anthocyanins can increase the ratio of LC3-II /LC3-I,BAX / BCL-2 ratio and the expression of Caspase-8,Beclin1 of SGC-7901 cells. Anthocyanins 51-63 BCL2 apoptosis regulator Homo sapiens 110-115 30133211-6 2016 The result of Western blot confirmed that mulberry anthocyanins can increase the ratio of LC3-II /LC3-I,BAX / BCL-2 ratio and the expression of Caspase-8,Beclin1 of SGC-7901 cells. Anthocyanins 51-63 caspase 8 Homo sapiens 144-153 30133211-6 2016 The result of Western blot confirmed that mulberry anthocyanins can increase the ratio of LC3-II /LC3-I,BAX / BCL-2 ratio and the expression of Caspase-8,Beclin1 of SGC-7901 cells. Anthocyanins 51-63 beclin 1 Homo sapiens 154-161 30133211-6 2016 The result of Western blot confirmed that mulberry anthocyanins can increase the ratio of LC3-II /LC3-I,BAX / BCL-2 ratio and the expression of Caspase-8,Beclin1 of SGC-7901 cells. Anthocyanins 51-63 sarcoglycan beta Homo sapiens 165-168 30133211-7 2016 Conclusion: Mulberry anthocyanins can inhibit the proliferation of human gastric cancer SGC-7901 cells, inducing cell apoptosis and autophagy. Anthocyanins 21-33 sarcoglycan beta Homo sapiens 88-91 26931451-7 2016 TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively. Anthocyanins 65-78 long intergenic non-protein coding RNA 1194 Homo sapiens 0-3 26931451-7 2016 TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively. Anthocyanins 65-78 long intergenic non-protein coding RNA 1194 Homo sapiens 8-11 26931451-7 2016 TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively. Anthocyanins 65-78 long intergenic non-protein coding RNA 1194 Homo sapiens 8-11 26931451-7 2016 TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively. Anthocyanins 65-78 long intergenic non-protein coding RNA 1194 Homo sapiens 8-11 26931451-7 2016 TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively. Anthocyanins 65-78 long intergenic non-protein coding RNA 1194 Homo sapiens 8-11 26931451-7 2016 TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively. Anthocyanins 65-78 long intergenic non-protein coding RNA 1194 Homo sapiens 8-11 26884602-0 2016 Functional diversification of the potato R2R3 MYB anthocyanin activators AN1, MYBA1, and MYB113 and their interaction with basic helix-loop-helix cofactors. Anthocyanins 50-61 transcription factor R2R3-MYB Solanum tuberosum 73-76 26884602-0 2016 Functional diversification of the potato R2R3 MYB anthocyanin activators AN1, MYBA1, and MYB113 and their interaction with basic helix-loop-helix cofactors. Anthocyanins 50-61 transcription factor MYB113-like Solanum tuberosum 78-83 26884602-8 2016 Versions of StMYBA1 and StMYB113 can also activate anthocyanin accumulation in tobacco leaves, with the exception of StMYB113-3, which has a partial R2R3 domain. Anthocyanins 51-62 transcription factor MYB113-like Solanum tuberosum 12-19 26912800-3 2016 Similarly, but to a different extent, three types of poplar CLV3-related peptides caused root meristem consumption, phyllotaxis disorder, anthocyanin accumulation and failure to enter the bolting stage. Anthocyanins 138-149 CLAVATA3 Arabidopsis thaliana 60-64 26471682-1 2016 Eight anthocyanidins, seven anthocyanins and two synthesized 4"-hydroxy flavyliums were examined as hydrogen donors to DPPH, ABTS and hydroxyl radicals, and as electron donors in the FRAP assay. Anthocyanins 6-20 mechanistic target of rapamycin kinase Homo sapiens 183-187 26968898-13 2016 PPAR agonists such as anthocyanidins and resveratrol present in nondairy items may also contribute to outcome. Anthocyanins 22-36 peroxisome proliferator activated receptor alpha Homo sapiens 0-4 26851572-8 2016 Transcript accumulation of VvCCoAOMT was detected in berry skins, and increased during berry ripening on the plant, and in cultured berries treated with ABA, concomitantly with accumulation of methylated anthocyanins, suggesting that anthocyanins may be substrates of this enzyme. Anthocyanins 204-216 caffeoyl-CoA O-methyltransferase Vitis vinifera 27-36 26851572-8 2016 Transcript accumulation of VvCCoAOMT was detected in berry skins, and increased during berry ripening on the plant, and in cultured berries treated with ABA, concomitantly with accumulation of methylated anthocyanins, suggesting that anthocyanins may be substrates of this enzyme. Anthocyanins 234-246 caffeoyl-CoA O-methyltransferase Vitis vinifera 27-36 26851572-11 2016 We conclude that VvCCoAOMT is a multifunctional O-methyltransferase that may contribute to anthocyanin methylation activity in grape berries, in particular under drought stress conditions. Anthocyanins 91-102 caffeoyl-CoA O-methyltransferase Vitis vinifera 17-26 26851572-11 2016 We conclude that VvCCoAOMT is a multifunctional O-methyltransferase that may contribute to anthocyanin methylation activity in grape berries, in particular under drought stress conditions. Anthocyanins 91-102 O-methyltransferase Vitis vinifera 48-67 25996649-2 2016 It was deemed necessary to determine whether major blueberry anthocyanins and catechins are ligands for the transcription factor peroxisome proliferator activated receptor alpha isoform (PPARalpha), and compare activation with known PPARalpha agonistic constituents, pterostilbene and resveratrol. Anthocyanins 61-73 peroxisome proliferator activated receptor alpha Rattus norvegicus 129-177 25996649-2 2016 It was deemed necessary to determine whether major blueberry anthocyanins and catechins are ligands for the transcription factor peroxisome proliferator activated receptor alpha isoform (PPARalpha), and compare activation with known PPARalpha agonistic constituents, pterostilbene and resveratrol. Anthocyanins 61-73 peroxisome proliferator activated receptor alpha Rattus norvegicus 187-196 26967923-3 2016 Anthocyanins (ANC) from 50% blueberry-50% blackberry (Blu-Bla) and 100% blackberry (Bla) fermented beverages at 50 muM cyanidin-3-glucoside equivalents increased (p < 0.05) glucose-stimulated insulin secretion from pancreatic beta-cells (iNS-1E) both when applied directly and following simulated absorption through Caco-2 cells (by 233 and 100 muIU insulin/mL, respectively). Anthocyanins 0-12 zinc finger MYND-type containing 10 Homo sapiens 54-57 26967923-3 2016 Anthocyanins (ANC) from 50% blueberry-50% blackberry (Blu-Bla) and 100% blackberry (Bla) fermented beverages at 50 muM cyanidin-3-glucoside equivalents increased (p < 0.05) glucose-stimulated insulin secretion from pancreatic beta-cells (iNS-1E) both when applied directly and following simulated absorption through Caco-2 cells (by 233 and 100 muIU insulin/mL, respectively). Anthocyanins 0-12 insulin Homo sapiens 195-202 26967923-3 2016 Anthocyanins (ANC) from 50% blueberry-50% blackberry (Blu-Bla) and 100% blackberry (Bla) fermented beverages at 50 muM cyanidin-3-glucoside equivalents increased (p < 0.05) glucose-stimulated insulin secretion from pancreatic beta-cells (iNS-1E) both when applied directly and following simulated absorption through Caco-2 cells (by 233 and 100 muIU insulin/mL, respectively). Anthocyanins 0-12 insulin Homo sapiens 353-360 26967923-5 2016 Taken together, anthocyanins, predominantly delphinidin-3-arabinoside, from fermented berry beverages have the potential to modulate DPP-IV and its substrate GLP-1, to increase insulin secretion, and to upregulate expression of mRNA of insulin-receptor associated genes and proteins in pancreatic beta-cells. Anthocyanins 16-28 dipeptidyl peptidase 4 Homo sapiens 133-139 26967923-5 2016 Taken together, anthocyanins, predominantly delphinidin-3-arabinoside, from fermented berry beverages have the potential to modulate DPP-IV and its substrate GLP-1, to increase insulin secretion, and to upregulate expression of mRNA of insulin-receptor associated genes and proteins in pancreatic beta-cells. Anthocyanins 16-28 glucagon Homo sapiens 158-163 26967923-5 2016 Taken together, anthocyanins, predominantly delphinidin-3-arabinoside, from fermented berry beverages have the potential to modulate DPP-IV and its substrate GLP-1, to increase insulin secretion, and to upregulate expression of mRNA of insulin-receptor associated genes and proteins in pancreatic beta-cells. Anthocyanins 16-28 insulin receptor Homo sapiens 236-252 26963650-4 2016 In this study, we confirmed that the total phenolic and anthocyanin contents of LRF fruit extracts (LRFEs) were 4906.5 +- 60.6 mg of gallic acid equivalents/100 g DW and 787.6 +- 34.1 mg of cyanindin-3-glucoside equivalents/100 g DW, respectively. Anthocyanins 56-67 CREB3 regulatory factor Homo sapiens 80-83 27047496-7 2016 Moreover, melatonin treatment increased the expression levels of the transcription factors MYB, bHLH, and WD40, which constitute the transcriptional activation complex responsible for coordinative regulation of anthocyanin biosynthetic genes. Anthocyanins 211-222 transcription factor MYB34-like Brassica oleracea 91-94 26884175-3 2016 This enhanced drought tolerance of arr1,10,12 plants can be attributed to enhanced cell membrane integrity, increased anthocyanin biosynthesis, abscisic acid (ABA) hypersensitivity, and reduced stomatal aperture, but not to altered stomatal density. Anthocyanins 118-129 response regulator 1 Arabidopsis thaliana 35-39 26471548-8 2016 Sour cherry extracts and selected anthocyanins inhibited the human salivary alpha-amylase catalyzed hydrolysis competitively. Anthocyanins 34-46 amylase alpha 1A Homo sapiens 67-89 26471644-5 2016 CSF had stronger anthocyanin binding ability at pH 2.0-3.6, while NSF had stronger anthocyanin binding ability at pH 3.6-4.5. Anthocyanins 83-94 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 66-69 26909931-9 2016 Seven MYB, three bHLH, and two WD40 genes, considered anthocyanin regulatory genes, were also identified. Anthocyanins 54-65 MYB proto-oncogene, transcription factor Homo sapiens 6-9 26717955-6 2016 Ler x Col-0 recombinant inbred line mapping and whole genome association mapping led to the identification of a glycoside hydrolase family 1-type gene, At1g60270/BGLU6, that encodes a homolog of acyl-glucose-dependent glucosyltransferases involved in the glycosylation of anthocyanins, possibly localized in the cytoplasm, and that is co-expressed with genes linked to phenylpropanoid biosynthesis. Anthocyanins 272-284 beta glucosidase 6 Arabidopsis thaliana 162-167 27158396-5 2016 The phosphorylation levels of Akt and/or P-38 were significantly increased by anthocyanins supplementation in primary cultured fibroblasts. Anthocyanins 78-90 thymoma viral proto-oncogene 1 Mus musculus 30-33 27158396-5 2016 The phosphorylation levels of Akt and/or P-38 were significantly increased by anthocyanins supplementation in primary cultured fibroblasts. Anthocyanins 78-90 mitogen-activated protein kinase 14 Mus musculus 41-45 27158396-6 2016 Gelatin zymography analysis of matrix metalloproteinase-2 (MMP-2) activity in conditioned medium collected from fibroblasts demonstrated that anthocyanins treatment significantly reduced MMP-2 activity. Anthocyanins 142-154 matrix metallopeptidase 2 Mus musculus 31-57 27158396-6 2016 Gelatin zymography analysis of matrix metalloproteinase-2 (MMP-2) activity in conditioned medium collected from fibroblasts demonstrated that anthocyanins treatment significantly reduced MMP-2 activity. Anthocyanins 142-154 matrix metallopeptidase 2 Mus musculus 59-64 27158396-6 2016 Gelatin zymography analysis of matrix metalloproteinase-2 (MMP-2) activity in conditioned medium collected from fibroblasts demonstrated that anthocyanins treatment significantly reduced MMP-2 activity. Anthocyanins 142-154 matrix metallopeptidase 2 Mus musculus 187-192 26870053-7 2016 Results showed that mdm-miR828 and mdm-miR858 regulated anthocyanin contents in both apple cultivars, while mdm-miR156 only affected anthocyanin accumulation in "Granny Smith," and miR5072 affected anthocyanin accumulation in "Starkrimson." Anthocyanins 56-67 MIR858 Malus domestica 39-45 25821013-4 2016 The expression of PAL and CHS was also related to that of AN1, a transcription factor involved in the synthesis of anthocyanins, suggesting that these genes are regulated in a coordinated manner. Anthocyanins 115-127 chalcone synthase 1A Solanum tuberosum 26-29 25821013-4 2016 The expression of PAL and CHS was also related to that of AN1, a transcription factor involved in the synthesis of anthocyanins, suggesting that these genes are regulated in a coordinated manner. Anthocyanins 115-127 transcription factor R2R3-MYB Solanum tuberosum 58-61 26925082-8 2016 Significant accumulation of anthocyanins in leaves transformed with the combination of LcMYB1 and LcbHLH3 were noticed, and this was associated with the up-regulation of two tobacco endogenous bHLH regulators, NtAn1a and NtAn1b, and late structural genes, like NtDFR and NtANS. Anthocyanins 28-40 basic helix-loop-helix protein A-like Nicotiana tabacum 210-216 26925082-8 2016 Significant accumulation of anthocyanins in leaves transformed with the combination of LcMYB1 and LcbHLH3 were noticed, and this was associated with the up-regulation of two tobacco endogenous bHLH regulators, NtAn1a and NtAn1b, and late structural genes, like NtDFR and NtANS. Anthocyanins 28-40 basic helix-loop-helix protein A-like Nicotiana tabacum 221-227 26821011-1 2016 Dihydroflavanol 4-reductase (DFR) is a key later enzyme involved in two polyphenols" (anthocyanins and proanthocyanidins (PAs)) biosynthesis, however it is not characterized in cotton yet. Anthocyanins 86-98 dihydroflavonol-4-reductase-like Gossypium hirsutum 0-27 25754879-5 2016 The expression of DFR and ANS paralleled the upward trend in anthocyanin accumulation, while CHS, CHI and F3H were upregulated before accumulation. Anthocyanins 61-72 dihydroflavonol-4-reductase Raphanus sativus 18-21 26858726-8 2015 A yeast two-hybrid assay confirmed the interaction of both SmMyb1 and SmMyb1Delta9 with an anthocyanin-related potato bHLH1 TF. Anthocyanins 91-102 transcription factor TT8-like Solanum tuberosum 118-123 26821011-1 2016 Dihydroflavanol 4-reductase (DFR) is a key later enzyme involved in two polyphenols" (anthocyanins and proanthocyanidins (PAs)) biosynthesis, however it is not characterized in cotton yet. Anthocyanins 86-98 dihydroflavonol-4-reductase-like Gossypium hirsutum 29-32 25564785-1 2016 BACKGROUND: Seedling roots of anthocyanin-rich corn (Zea mays) cultivars contain high levels of phenylalanine ammonia lyase (PAL) activity. Anthocyanins 30-41 phenylalanine ammonia-lyase Zea mays 96-123 25564785-1 2016 BACKGROUND: Seedling roots of anthocyanin-rich corn (Zea mays) cultivars contain high levels of phenylalanine ammonia lyase (PAL) activity. Anthocyanins 30-41 phenylalanine ammonia-lyase Zea mays 125-128 26793227-7 2015 Heterologous expression of the FLS genes within tobacco host plants demonstrated conservation of function, with the transgenes promoting flavonol biosynthesis and inhibiting anthocyanin accumulation, so resulting in white flowers. Anthocyanins 174-185 flavonol synthase/flavanone 3-hydroxylase-like Nicotiana tabacum 31-34 26793227-8 2015 Conversely, overexpression of DFR genes in tobacco displayed down-regulation of the endogenous NtFLS gene, and the promotion of anthocyanin synthesis. Anthocyanins 128-139 dihydroflavonol-4-reductase Nicotiana tabacum 30-33 26793227-9 2015 On this basis, we propose a model in which FLS and DFR gene-products compete for common substrates in order to direct the biosynthesis of flavonols and anthocyanins, respectively, thereby determining white vs. red coloration of flowers. Anthocyanins 152-164 flavonol synthase/flavanone 3-hydroxylase-like Nicotiana tabacum 43-46 26793227-9 2015 On this basis, we propose a model in which FLS and DFR gene-products compete for common substrates in order to direct the biosynthesis of flavonols and anthocyanins, respectively, thereby determining white vs. red coloration of flowers. Anthocyanins 152-164 dihydroflavonol-4-reductase Nicotiana tabacum 51-54 27034731-3 2016 The results showed that these anthocyanins decreased the levels of ROS and XO-1 but increased the levels of SOD and HO-1. Anthocyanins 30-42 heme oxygenase 1 Homo sapiens 116-120 26497001-7 2016 Expression analysis of flavonoid structural genes revealed the strong down-regulation of the flavonoid-related genes anthocyanidin synthase (ANS) and dihydroflavonol reductase (DFR) genes and also the reduction of the anthocyanin-related gene UDP glucose:flavonoid 3-O-glucosyl transferase (UFGT), which was dependent of the transgene expression. Anthocyanins 218-229 cinnamoyl-CoA reductase 1-like Nicotiana tabacum 177-180 26608698-0 2016 Arabidopsis pab1, a mutant with reduced anthocyanins in immature seeds from banyuls, harbors a mutation in the MATE transporter FFT. Anthocyanins 40-52 detoxifying efflux carrier 35 Arabidopsis thaliana 128-131 26574599-0 2016 Redox-Dependent Modulation of Anthocyanin Biosynthesis by the TCP Transcription Factor TCP15 during Exposure to High Light Intensity Conditions in Arabidopsis. Anthocyanins 30-41 TCP family transcription factor Arabidopsis thaliana 87-92 26608698-12 2016 These results suggest that FFT acts at the vacuolar membrane in anthocyanin accumulation in the Arabidopsis seed coat, and that our screening strategy can reveal anthocyanin-related genes that have not been found by standard screening. Anthocyanins 64-75 detoxifying efflux carrier 35 Arabidopsis thaliana 27-30 26608698-12 2016 These results suggest that FFT acts at the vacuolar membrane in anthocyanin accumulation in the Arabidopsis seed coat, and that our screening strategy can reveal anthocyanin-related genes that have not been found by standard screening. Anthocyanins 162-173 detoxifying efflux carrier 35 Arabidopsis thaliana 27-30 26955771-6 2016 We found that seven of them could bind to the protein NFkappaB (catechin, leucoanthocyanidin, niacin, phenylethylamine, theobromine, theophylline, and thiamin). Anthocyanins 74-92 nuclear factor kappa B subunit 1 Homo sapiens 54-62 26779194-8 2015 Other features of the MBW gene regulation networks are also conserved within legumes, including the ability for the anthocyanin MBW complexes to activate the expression of the AN1/TT8 clade bHLH factor. Anthocyanins 116-127 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 180-183 26827953-6 2016 In addition to the high-affinity 1,25D hormone, low-affinity nutritional VDR ligands including curcumin, polyunsaturated fatty acids, and anthocyanidins initiate VDR signaling, whereas the longevity principles resveratrol and SIRT1 potentiate VDR signaling. Anthocyanins 138-152 vitamin D receptor Homo sapiens 73-76 26827953-6 2016 In addition to the high-affinity 1,25D hormone, low-affinity nutritional VDR ligands including curcumin, polyunsaturated fatty acids, and anthocyanidins initiate VDR signaling, whereas the longevity principles resveratrol and SIRT1 potentiate VDR signaling. Anthocyanins 138-152 vitamin D receptor Homo sapiens 162-165 26827953-6 2016 In addition to the high-affinity 1,25D hormone, low-affinity nutritional VDR ligands including curcumin, polyunsaturated fatty acids, and anthocyanidins initiate VDR signaling, whereas the longevity principles resveratrol and SIRT1 potentiate VDR signaling. Anthocyanins 138-152 vitamin D receptor Homo sapiens 162-165 26253159-2 2015 In this study, multi-type structural analysis of the proteins encoded by five anthocyanin biosynthesis genes VvF3H, VvPAL, VvCHS3, VvCHS2 and VvLDOX, in addition to nine of their homologous genes revealed that proteins in grapevine shared a high similarity with that in kiwi, red orange and some other species in which the biosynthesis of anthocyanin significantly influenced by low temperature as proved by previous studies. Anthocyanins 78-89 naringenin,2-oxoglutarate 3-dioxygenase Vitis vinifera 109-114 26253159-2 2015 In this study, multi-type structural analysis of the proteins encoded by five anthocyanin biosynthesis genes VvF3H, VvPAL, VvCHS3, VvCHS2 and VvLDOX, in addition to nine of their homologous genes revealed that proteins in grapevine shared a high similarity with that in kiwi, red orange and some other species in which the biosynthesis of anthocyanin significantly influenced by low temperature as proved by previous studies. Anthocyanins 78-89 chalcone synthase 2 Vitis vinifera 123-129 26253159-2 2015 In this study, multi-type structural analysis of the proteins encoded by five anthocyanin biosynthesis genes VvF3H, VvPAL, VvCHS3, VvCHS2 and VvLDOX, in addition to nine of their homologous genes revealed that proteins in grapevine shared a high similarity with that in kiwi, red orange and some other species in which the biosynthesis of anthocyanin significantly influenced by low temperature as proved by previous studies. Anthocyanins 78-89 leucoanthocyanidin dioxygenase Vitis vinifera 142-148 26347569-4 2015 CHIL loss-of-function mutations led to a strong reduction in the proanthocyanidin and flavonol levels in seeds, but not in the anthocyanin levels in leaves. Anthocyanins 127-138 Chalcone-flavanone isomerase family protein Arabidopsis thaliana 0-4 26636322-10 2015 Particularly, some flavonoid biosynthetic pathway genes, including C4H, CHS, CHI, F3H, DFR and ANS, as well as some transcription factors (TFs), including MYB (putative MYB86 and MYB39), WDR and MADS, were down-regulated in YW fruit, concurrent with a reduction in anthocyanin accumulation in the yellow pigment phenotype, whereas a putative transcription repressor MYB1R was up-regulated in YW fruit. Anthocyanins 265-276 transcription factor MYB12-like Fragaria vesca 155-158 26395027-0 2015 Phytoestrogenic activity of blackcurrant (Ribes nigrum) anthocyanins is mediated through estrogen receptor alpha. Anthocyanins 56-68 estrogen receptor 1 Homo sapiens 89-112 26574599-3 2016 In this work, we describe that the class-I TCP protein TCP15 inhibits anthocyanin accumulation during exposure of plants to high light intensity by modulating the expression of transcription factors involved in the induction of anthocyanin biosynthesis genes, as suggested by the study of plants that express TCP15 from the 35SCaMV promoter and mutants in TCP15 and the related gene TCP14. Anthocyanins 70-81 TCP family transcription factor Arabidopsis thaliana 55-60 26574599-3 2016 In this work, we describe that the class-I TCP protein TCP15 inhibits anthocyanin accumulation during exposure of plants to high light intensity by modulating the expression of transcription factors involved in the induction of anthocyanin biosynthesis genes, as suggested by the study of plants that express TCP15 from the 35SCaMV promoter and mutants in TCP15 and the related gene TCP14. Anthocyanins 70-81 TCP family transcription factor Arabidopsis thaliana 309-314 26574599-3 2016 In this work, we describe that the class-I TCP protein TCP15 inhibits anthocyanin accumulation during exposure of plants to high light intensity by modulating the expression of transcription factors involved in the induction of anthocyanin biosynthesis genes, as suggested by the study of plants that express TCP15 from the 35SCaMV promoter and mutants in TCP15 and the related gene TCP14. Anthocyanins 70-81 TCP family transcription factor Arabidopsis thaliana 309-314 26574599-3 2016 In this work, we describe that the class-I TCP protein TCP15 inhibits anthocyanin accumulation during exposure of plants to high light intensity by modulating the expression of transcription factors involved in the induction of anthocyanin biosynthesis genes, as suggested by the study of plants that express TCP15 from the 35SCaMV promoter and mutants in TCP15 and the related gene TCP14. Anthocyanins 70-81 TEOSINTE BRANCHED, cycloidea and PCF (TCP) 14 Arabidopsis thaliana 383-388 26574599-3 2016 In this work, we describe that the class-I TCP protein TCP15 inhibits anthocyanin accumulation during exposure of plants to high light intensity by modulating the expression of transcription factors involved in the induction of anthocyanin biosynthesis genes, as suggested by the study of plants that express TCP15 from the 35SCaMV promoter and mutants in TCP15 and the related gene TCP14. Anthocyanins 228-239 TCP family transcription factor Arabidopsis thaliana 55-60 26574599-3 2016 In this work, we describe that the class-I TCP protein TCP15 inhibits anthocyanin accumulation during exposure of plants to high light intensity by modulating the expression of transcription factors involved in the induction of anthocyanin biosynthesis genes, as suggested by the study of plants that express TCP15 from the 35SCaMV promoter and mutants in TCP15 and the related gene TCP14. Anthocyanins 228-239 TCP family transcription factor Arabidopsis thaliana 309-314 26574599-3 2016 In this work, we describe that the class-I TCP protein TCP15 inhibits anthocyanin accumulation during exposure of plants to high light intensity by modulating the expression of transcription factors involved in the induction of anthocyanin biosynthesis genes, as suggested by the study of plants that express TCP15 from the 35SCaMV promoter and mutants in TCP15 and the related gene TCP14. Anthocyanins 228-239 TCP family transcription factor Arabidopsis thaliana 309-314 26574599-3 2016 In this work, we describe that the class-I TCP protein TCP15 inhibits anthocyanin accumulation during exposure of plants to high light intensity by modulating the expression of transcription factors involved in the induction of anthocyanin biosynthesis genes, as suggested by the study of plants that express TCP15 from the 35SCaMV promoter and mutants in TCP15 and the related gene TCP14. Anthocyanins 228-239 TEOSINTE BRANCHED, cycloidea and PCF (TCP) 14 Arabidopsis thaliana 383-388 26574599-4 2016 In addition, the effect of TCP15 on anthocyanin accumulation is lost after prolonged incubation under high light intensity conditions. Anthocyanins 36-47 TCP family transcription factor Arabidopsis thaliana 27-32 26574599-6 2016 Thus, redox modulation of TCP15 activity in vivo by high light intensity may serve to adjust anthocyanin accumulation to the duration of exposure to high irradiation conditions. Anthocyanins 93-104 TCP family transcription factor Arabidopsis thaliana 26-31 26152793-2 2015 Cyanidin-3-O-glucoside (C3G), the most active anthocyanin in the blueberry extracts, has been demonstrated to have pulmonary protective effects in some ALI models. Anthocyanins 46-57 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 24-27 26395027-3 2015 METHODS AND RESULTS: Microarray analysis and Ingenuity Pathway Analysis showed that BCE activated the ERalpha pathway, whereas quantitative-PCR confirmed that BCE and four types of anthocyanins up-regulated genes downstream of ERalpha. Anthocyanins 182-194 estrogen receptor 1 Homo sapiens 228-235 26395027-6 2015 Anthocyanins stimulated ERalpha transcriptional activity in human ERalpha reporter assays and induced alkaline phosphatase activity in Ishikawa cells. Anthocyanins 0-12 estrogen receptor 1 Homo sapiens 24-31 26395027-6 2015 Anthocyanins stimulated ERalpha transcriptional activity in human ERalpha reporter assays and induced alkaline phosphatase activity in Ishikawa cells. Anthocyanins 0-12 estrogen receptor 1 Homo sapiens 66-73 26395027-7 2015 Competition assays and in silico analysis indicated that anthocyanins bind to ERalpha. Anthocyanins 57-69 estrogen receptor 1 Homo sapiens 78-85 26422991-4 2015 Two genes of the anthocyanin pathway, chalcone isomerase (CHI) and UDP-glucose:flavonoid 3-O-glucosyltransferase (UFGT), were sequenced in 22 grapevine varieties. Anthocyanins 17-28 chalcone--flavonone isomerase 2 Vitis vinifera 58-61 26576746-0 2015 MYBD employed by HY5 increases anthocyanin accumulation via repression of MYBL2 in Arabidopsis. Anthocyanins 31-42 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 17-20 26576746-0 2015 MYBD employed by HY5 increases anthocyanin accumulation via repression of MYBL2 in Arabidopsis. Anthocyanins 31-42 MYB-like 2 Arabidopsis thaliana 74-79 26576746-6 2015 MYBD expression increased in response to light or cytokinin, and MYBD enhanced anthocyanin biosynthesis via repression of MYBL2, which encodes a transcription factor that has a negative effect on this process. Anthocyanins 79-90 MYB-like 2 Arabidopsis thaliana 122-127 26576746-8 2015 HY5 directly binds to the MYBD promoter, which indicates that MYBD acts on HY5-downstream in light- or cytokinin-triggered signaling pathways, leading to anthocyanin accumulation. Anthocyanins 154-165 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 0-3 26576746-8 2015 HY5 directly binds to the MYBD promoter, which indicates that MYBD acts on HY5-downstream in light- or cytokinin-triggered signaling pathways, leading to anthocyanin accumulation. Anthocyanins 154-165 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 75-78 26588092-0 2015 GWA Mapping of Anthocyanin Accumulation Reveals Balancing Selection of MYB90 in Arabidopsis thaliana. Anthocyanins 15-26 myb domain protein 90 Arabidopsis thaliana 71-76 26588092-4 2015 Sequence and expression analyses of alleles of the candidate gene MYB90 identified a causal polymorphism at amino acid (AA) position 210 of this transcription factor of the anthocyanin biosynthesis pathway. Anthocyanins 173-184 myb domain protein 90 Arabidopsis thaliana 66-71 26544846-0 2015 Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-kappaB. Anthocyanins 0-11 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 203-212 26544846-3 2015 We investigated the therapeutic effects of anthocyanin extracted from black soybean seed coats (AEBS) in a murine model of collagen-induced arthritis (CIA) and human peripheral blood mononuclear cells (PBMCs) and explored possible mechanisms by which AEBS might exert anti-arthritic effects. Anthocyanins 43-54 nuclear receptor coactivator 5 Mus musculus 123-155 26260864-3 2015 Cyanidin-3-glucoside (C3G) and cyanidin-3-galactoside (C3Ga) are major anthocyanins in Saskatoon berry (SB) powder. Anthocyanins 71-83 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 0-25 26048881-5 2015 We further show that anthocyanin accumulation is also repressed in fah1 mutants and that this repression is specific to tissues in which F5H is normally expressed. Anthocyanins 21-32 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 67-71 26048881-5 2015 We further show that anthocyanin accumulation is also repressed in fah1 mutants and that this repression is specific to tissues in which F5H is normally expressed. Anthocyanins 21-32 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 137-140 26048881-6 2015 Finally, we show that repression of both HCE and anthocyanin biosynthesis in fah1 mutants is dependent on the MED5a/5b subunits of the transcriptional coregulatory complex Mediator, which are similarly required for the repression of lignin biosynthesis and the stunted growth of the phenylpropanoid pathway mutant reduced epidermal fluorescence8. Anthocyanins 49-60 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 77-81 26048881-7 2015 Taken together, these observations show that the synthesis of HCEs and anthocyanins is actively repressed in a MEDIATOR-dependent manner in Arabidopsis fah1 mutants and support an emerging model in which MED5a/5b act as central players in the homeostatic repression of phenylpropanoid metabolism. Anthocyanins 71-83 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 152-156 26378103-0 2015 The Arabidopsis Transcription Factor MYB112 Promotes Anthocyanin Formation during Salinity and under High Light Stress. Anthocyanins 53-64 myb domain protein 112 Arabidopsis thaliana 37-43 26378103-2 2015 Here, we report MYB112 as a formerly unknown regulator of anthocyanin accumulation in Arabidopsis (Arabidopsis thaliana). Anthocyanins 58-69 myb domain protein 112 Arabidopsis thaliana 16-22 26378103-4 2015 In addition, upon extended induction, MYB112 also positively affects the expression of PRODUCTION OF ANTHOCYANIN PIGMENT1, a key TF of anthocyanin biosynthesis, but acts negatively toward MYB12 and MYB111, which both control flavonol biosynthesis. Anthocyanins 135-146 myb domain protein 112 Arabidopsis thaliana 38-44 26378103-4 2015 In addition, upon extended induction, MYB112 also positively affects the expression of PRODUCTION OF ANTHOCYANIN PIGMENT1, a key TF of anthocyanin biosynthesis, but acts negatively toward MYB12 and MYB111, which both control flavonol biosynthesis. Anthocyanins 135-146 production of anthocyanin pigment 1 Arabidopsis thaliana 87-121 26378103-7 2015 We further show that MYB112 expression is up-regulated by salinity and high light stress, environmental parameters that both require the MYB112 TF for anthocyanin accumulation under these stresses. Anthocyanins 151-162 myb domain protein 112 Arabidopsis thaliana 21-27 26378103-7 2015 We further show that MYB112 expression is up-regulated by salinity and high light stress, environmental parameters that both require the MYB112 TF for anthocyanin accumulation under these stresses. Anthocyanins 151-162 myb domain protein 112 Arabidopsis thaliana 137-143 26378103-9 2015 Thus, MYB112 constitutes a regulator that promotes anthocyanin accumulation under abiotic stress conditions. Anthocyanins 51-62 myb domain protein 112 Arabidopsis thaliana 6-12 26530088-8 2015 Moreover, we show that MYB75, a component of the WD-repeat/bHLH/MYB complex regulating anthocyanin production, is a direct transcriptional target of FIL. Anthocyanins 87-98 production of anthocyanin pigment 1 Arabidopsis thaliana 23-28 26530088-8 2015 Moreover, we show that MYB75, a component of the WD-repeat/bHLH/MYB complex regulating anthocyanin production, is a direct transcriptional target of FIL. Anthocyanins 87-98 Plant-specific transcription factor YABBY family protein Arabidopsis thaliana 149-152 26530088-10 2015 Upon perception of JA signal, degradation of JAZ3 by the SCF(COI1) complex releases YABs to activate a subset of JA-regulated genes in leaves leading to anthocyanin accumulation, chlorophyll loss, and reduced bacterial defense. Anthocyanins 153-164 jasmonate-zim-domain protein 3 Arabidopsis thaliana 45-49 26530088-10 2015 Upon perception of JA signal, degradation of JAZ3 by the SCF(COI1) complex releases YABs to activate a subset of JA-regulated genes in leaves leading to anthocyanin accumulation, chlorophyll loss, and reduced bacterial defense. Anthocyanins 153-164 RNI-like superfamily protein Arabidopsis thaliana 61-65 26422991-4 2015 Two genes of the anthocyanin pathway, chalcone isomerase (CHI) and UDP-glucose:flavonoid 3-O-glucosyltransferase (UFGT), were sequenced in 22 grapevine varieties. Anthocyanins 17-28 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 67-112 26422991-4 2015 Two genes of the anthocyanin pathway, chalcone isomerase (CHI) and UDP-glucose:flavonoid 3-O-glucosyltransferase (UFGT), were sequenced in 22 grapevine varieties. Anthocyanins 17-28 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 114-118 26448466-8 2015 The formative SsMYB3-complex represses anthocyanin accumulation by directly suppressing the expression of the final anthocyanin structural gene NtUFGT, through competitive inhibition or destabilization of the endogenous NtAn2-complex formation. Anthocyanins 39-50 transcription factor MYB114-like Nicotiana tabacum 220-225 26395841-0 2015 A Grapevine Anthocyanin Acyltransferase, Transcriptionally Regulated by VvMYBA, Can Produce Most Acylated Anthocyanins Present in Grape Skins. Anthocyanins 106-118 transcription factor MYB113-like Vitis vinifera 72-78 26395841-3 2015 VvMYBA1 and VvMYBA2 activate anthocyanin biosynthesis in grapevine (Vitis vinifera) and are nonfunctional in white grapevine cultivars. Anthocyanins 29-40 MYBA1 Vitis vinifera 0-7 26395841-3 2015 VvMYBA1 and VvMYBA2 activate anthocyanin biosynthesis in grapevine (Vitis vinifera) and are nonfunctional in white grapevine cultivars. Anthocyanins 29-40 LOW QUALITY PROTEIN: transcription factor MYB90 Vitis vinifera 12-19 26395841-5 2015 The results showed that VvMYBA is a positive regulator of the later stages of anthocyanin synthesis, modification, and transport in cv Shiraz. Anthocyanins 78-89 transcription factor MYB113-like Vitis vinifera 24-30 26448466-8 2015 The formative SsMYB3-complex represses anthocyanin accumulation by directly suppressing the expression of the final anthocyanin structural gene NtUFGT, through competitive inhibition or destabilization of the endogenous NtAn2-complex formation. Anthocyanins 116-127 transcription factor MYB114-like Nicotiana tabacum 220-225 26113165-1 2015 KEY MESSAGE: The Md - MYB10 R6 gene from apple is capable of self-regulating in heterologous host species and enhancing anthocyanin pigmentation, but the activity of MYB10 is dependent on endogenous protein partners. Anthocyanins 120-131 transcription factor MYB113-like Malus domestica 22-27 26315029-8 2015 Results reported in the present study demonstrate that C3G, the most abundant anthocyanin in diet, may represent a new approach and highly effective strategy in reducing carcinogenesis. Anthocyanins 78-89 Rap guanine nucleotide exchange factor 1 Homo sapiens 55-58 26113165-3 2015 Apples (Malus x domestica) containing an allelic variant of the anthocyanin regulator, Md-MYB10 R6 , are highly pigmented throughout the plant, due to autoregulation by MYB10 upon its own promoter. Anthocyanins 64-75 transcription factor MYB113-like Malus domestica 90-95 26113165-3 2015 Apples (Malus x domestica) containing an allelic variant of the anthocyanin regulator, Md-MYB10 R6 , are highly pigmented throughout the plant, due to autoregulation by MYB10 upon its own promoter. Anthocyanins 64-75 transcription factor MYB113-like Malus domestica 169-174 26113165-5 2015 The Md-MYB10 R6 transgene (MYB10-R6 pro :MYB10:MYB10 term ) activated anthocyanin synthesis when transiently expressed in Antirrhinum rosea (dorsea) petals and petunia leaf discs. Anthocyanins 70-81 transcription factor MYB113-like Malus domestica 7-12 26113165-5 2015 The Md-MYB10 R6 transgene (MYB10-R6 pro :MYB10:MYB10 term ) activated anthocyanin synthesis when transiently expressed in Antirrhinum rosea (dorsea) petals and petunia leaf discs. Anthocyanins 70-81 transcription factor MYB113-like Malus domestica 27-32 26113165-5 2015 The Md-MYB10 R6 transgene (MYB10-R6 pro :MYB10:MYB10 term ) activated anthocyanin synthesis when transiently expressed in Antirrhinum rosea (dorsea) petals and petunia leaf discs. Anthocyanins 70-81 transcription factor MYB113-like Malus domestica 27-32 26113165-5 2015 The Md-MYB10 R6 transgene (MYB10-R6 pro :MYB10:MYB10 term ) activated anthocyanin synthesis when transiently expressed in Antirrhinum rosea (dorsea) petals and petunia leaf discs. Anthocyanins 70-81 transcription factor MYB113-like Malus domestica 27-32 26113165-8 2015 In petunia flowers, where endogenous components including MYB-bHLH-WDR (MBW) proteins were present, expression of the Md-MYB10 R6 promoter was initiated, allowing auto-regulation to occur and activating anthocyanin production. Anthocyanins 203-214 transcription factor MYB113-like Malus domestica 121-126 26113165-9 2015 Md-MYB10 is capable of operating within the petunia MBW gene regulation network that controls the expression of the anthocyanin biosynthesis genes, AN1 (bHLH) and MYBx (R3-MYB repressor) in petals. Anthocyanins 116-127 transcription factor MYB113-like Malus domestica 3-8 26413797-6 2015 The anthocyanin delphinidin-3-O-arabinoside had the highest binding affinity for the dimerization domain as a homodimer (-7.2 kcal/mol) and transcription domain (-8.3 kcal/mol) of HNF-1alpha. Anthocyanins 4-15 HNF1 homeobox A Homo sapiens 180-190 26413797-9 2015 Nuclear expression of HNF-1alpha was measured in Caco-2 and human normal colon cells treated with blueberry and blackberry anthocyanin extracts. Anthocyanins 123-134 HNF1 homeobox A Homo sapiens 22-32 26413797-13 2015 Anthocyanins significantly increased nuclear HNF-1alpha expression, suggesting that these compounds might regulate the genes HNF-1alpha promotes. Anthocyanins 0-12 HNF1 homeobox A Homo sapiens 45-55 26413797-13 2015 Anthocyanins significantly increased nuclear HNF-1alpha expression, suggesting that these compounds might regulate the genes HNF-1alpha promotes. Anthocyanins 0-12 HNF1 homeobox A Homo sapiens 125-135 26442042-10 2015 Transcription factors regulating anthocyanin metabolism and their methylation, MYB, OMT, UFGT, and DFR, were expressed differentially among the treatments, overall in agreement with the metabolite profiles. Anthocyanins 33-44 MYB proto-oncogene, transcription factor Homo sapiens 79-82 26405619-2 2015 Comparative FRAP studies show 2"- and 4"-methoxy substituents have higher antioxidant activities, which may be attributed to both resonance and inductive effects.Graphical abstract:Anthocyanidins as reducing agents. Anthocyanins 181-195 mechanistic target of rapamycin kinase Homo sapiens 12-16 26442064-3 2015 Dihydroflavonol 4-reductase (DFR) is a vital enzyme of the flavonoid pathway which displays major impact on the formation of anthocyanins, flavan 3-ols and flavonols. Anthocyanins 125-137 putative anthocyanidin reductase Gossypium hirsutum 0-27 25858301-6 2015 Computational studies were performed to provide a structural characterization of the binding site of hGLUT1 to glucose or different anthocyanins under different forms. Anthocyanins 132-144 solute carrier family 2 member 1 Homo sapiens 101-107 25858301-9 2015 From MD simulations, hGLUT1 was found to form complexes with all anthocyanins tested in the different protonation states. Anthocyanins 65-77 solute carrier family 2 member 1 Homo sapiens 21-27 26341899-6 2015 PFT1 was also required for the expression of several glucose-induced genes, including those encoding cell wall components and enzymes, regulatory and enzymatic components of anthocyanin biosynthesis, and flavonoid and glucosinolate biosynthetic pathways. Anthocyanins 174-185 phytochrome and flowering time regulatory protein (PFT1) Arabidopsis thaliana 0-4 26442064-3 2015 Dihydroflavonol 4-reductase (DFR) is a vital enzyme of the flavonoid pathway which displays major impact on the formation of anthocyanins, flavan 3-ols and flavonols. Anthocyanins 125-137 putative anthocyanidin reductase Gossypium hirsutum 29-32 26442064-4 2015 The substrate specificity of the DFR was found to play a crucial role in determination of type of anthocyanidins. Anthocyanins 98-112 putative anthocyanidin reductase Gossypium hirsutum 33-36 26259175-0 2015 Phytochrome-interacting factors PIF4 and PIF5 negatively regulate anthocyanin biosynthesis under red light in Arabidopsis seedlings. Anthocyanins 66-77 phytochrome interacting factor 4 Arabidopsis thaliana 32-36 26259175-7 2015 Taken together, these results suggest that PIF4 and PIF5 negatively regulate red light-induced anthocyanin accumulation through transcriptional repression of the anthocyanin biosynthetic genes in Arabidopsis. Anthocyanins 95-106 phytochrome interacting factor 4 Arabidopsis thaliana 43-47 26259175-0 2015 Phytochrome-interacting factors PIF4 and PIF5 negatively regulate anthocyanin biosynthesis under red light in Arabidopsis seedlings. Anthocyanins 66-77 phytochrome interacting factor 3-like 6 Arabidopsis thaliana 41-45 26259175-7 2015 Taken together, these results suggest that PIF4 and PIF5 negatively regulate red light-induced anthocyanin accumulation through transcriptional repression of the anthocyanin biosynthetic genes in Arabidopsis. Anthocyanins 95-106 phytochrome interacting factor 3-like 6 Arabidopsis thaliana 52-56 26308527-6 2015 However, only SlAN2 acts as a positive regulator of anthocyanin synthesis in vegetative tissues under high light or low temperature conditions. Anthocyanins 52-63 transcription factor MYB75 Solanum lycopersicum 14-19 26259175-7 2015 Taken together, these results suggest that PIF4 and PIF5 negatively regulate red light-induced anthocyanin accumulation through transcriptional repression of the anthocyanin biosynthetic genes in Arabidopsis. Anthocyanins 162-173 phytochrome interacting factor 4 Arabidopsis thaliana 43-47 26259175-7 2015 Taken together, these results suggest that PIF4 and PIF5 negatively regulate red light-induced anthocyanin accumulation through transcriptional repression of the anthocyanin biosynthetic genes in Arabidopsis. Anthocyanins 162-173 phytochrome interacting factor 3-like 6 Arabidopsis thaliana 52-56 26259194-4 2015 Overexpression of miR778 moderately enhanced primary and lateral root growth, free phosphate accumulation in shoots, and accumulation of anthocyanin under Pi deficient conditions. Anthocyanins 137-148 MIR778 Arabidopsis thaliana 18-24 25752620-1 2015 Cyanidin-3-O-glucoside (C3G), an anthocyanin belonging to the flavonoid family and commonly present in food and vegetables in human diet, has exhibited anti-inflammatory and anti-oxidant effects. Anthocyanins 33-44 Rap guanine nucleotide exchange factor 1 Homo sapiens 24-27 26246845-14 2015 Chromatographic characterization of the GE revealed a large number of closely eluting components containing proanthocyanidins, catechins, anthocyanins and their secondary metabolites that corresponded with the observed DGAT1 enzyme inhibition in the cell-free model. Anthocyanins 138-150 diacylglycerol O-acyltransferase 1 Homo sapiens 219-224 25494721-2 2015 In this study, we identified a new allele of ROOT HAIR DEFECTIVE3 (RHD3) showing an anthocyanin overaccumulation phenotype under nitrogen starvation conditions. Anthocyanins 84-95 Root hair defective 3 GTP-binding protein (RHD3) Arabidopsis thaliana 67-71 25494721-4 2015 We hypothesized that RHD3 achieves its negative effect on anthocyanin biosynthesis via an ethylene-regulating pathway. Anthocyanins 58-69 Root hair defective 3 GTP-binding protein (RHD3) Arabidopsis thaliana 21-25 25494721-7 2015 In addition, inactivating RHD3 partially reversed the suppressive effect of ETO1 inactivation-evoked endogenous ethylene production on anthocyanin accumulation. Anthocyanins 135-146 Root hair defective 3 GTP-binding protein (RHD3) Arabidopsis thaliana 26-30 25494721-7 2015 In addition, inactivating RHD3 partially reversed the suppressive effect of ETO1 inactivation-evoked endogenous ethylene production on anthocyanin accumulation. Anthocyanins 135-146 tetratricopeptide repeat (TPR)-containing protein Arabidopsis thaliana 76-80 25494721-8 2015 The expression of nitrogen starvation-induced anthocyanin biosynthesis genes was negatively regulated by RHD3, but ethylene response genes were positively regulated by RHD3. Anthocyanins 46-57 Root hair defective 3 GTP-binding protein (RHD3) Arabidopsis thaliana 105-109 25494721-11 2015 This study uncovered a new physiological function of RHD3 in nitrogen starvation-induced anthocyanin accumulation and ethylene homeostasis. Anthocyanins 89-100 Root hair defective 3 GTP-binding protein (RHD3) Arabidopsis thaliana 53-57 25585663-3 2015 These genes are highly homologous to maize C1 and rice OsC1, regulators for anthocyanin biosynthesis, but they control seed pigmentation in maize and rice. Anthocyanins 76-87 anthocyanin regulatory C1 protein Zea mays 43-59 26022682-6 2015 Mesenteric adipose tissue weight and serum leptin levels were significantly lowered by quercetin, hesperetin and anthocyanins. Anthocyanins 113-125 leptin Mus musculus 43-49 25944785-3 2015 It has been demonstrated that anthocyanins and one of their representative metabolites, protocatechuic acid (PCA), ameliorate hyperglycemia, and insulin sensitivity. Anthocyanins 30-42 insulin Homo sapiens 145-152 25911741-7 2015 In A. thaliana, the seed-specific TF complex (TT2, TT8, and TTG1) may regulate all the anthocyanin pathway genes, in addition to the proanthocyanidin-specific BAN. Anthocyanins 87-98 Duplicated homeodomain-like superfamily protein Arabidopsis thaliana 46-49 25911741-7 2015 In A. thaliana, the seed-specific TF complex (TT2, TT8, and TTG1) may regulate all the anthocyanin pathway genes, in addition to the proanthocyanidin-specific BAN. Anthocyanins 87-98 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 51-54 25911741-7 2015 In A. thaliana, the seed-specific TF complex (TT2, TT8, and TTG1) may regulate all the anthocyanin pathway genes, in addition to the proanthocyanidin-specific BAN. Anthocyanins 87-98 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 60-64 25916310-8 2015 Concomitantly, upregulated expression was detected for several anthocyanin biosynthetic genes, including PAL, CHS, DFR, ANS and 3GT. Anthocyanins 63-74 dihydroflavonol 4-reductase Solanum lycopersicum 115-118 26116070-7 2015 Anthocyanins ameliorated intra-renal lipid concentrations in db/db mice with improvement of glomerular matrix expansion and inflammation, which was related to increased phosphorylation of AMPK and activation of peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma, and inhibited the activity of acetyl-CoA carboxylase and sterol regulatory element-binding protein 1. Anthocyanins 0-12 peroxisome proliferator activated receptor alpha Mus musculus 211-266 26116070-7 2015 Anthocyanins ameliorated intra-renal lipid concentrations in db/db mice with improvement of glomerular matrix expansion and inflammation, which was related to increased phosphorylation of AMPK and activation of peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma, and inhibited the activity of acetyl-CoA carboxylase and sterol regulatory element-binding protein 1. Anthocyanins 0-12 peroxisome proliferator activated receptor gamma Mus musculus 271-280 26116070-7 2015 Anthocyanins ameliorated intra-renal lipid concentrations in db/db mice with improvement of glomerular matrix expansion and inflammation, which was related to increased phosphorylation of AMPK and activation of peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma, and inhibited the activity of acetyl-CoA carboxylase and sterol regulatory element-binding protein 1. Anthocyanins 0-12 sterol regulatory element binding transcription factor 1 Mus musculus 339-382 26109181-8 2015 We observed that overexpression of the Tc-MYBPA gene resulted in increased expression of several key genes encoding the major structural enzymes of the PA and anthocyanidin pathway, including DFR (dihydroflavanol reductase), LDOX (leucoanthocyanidin dioxygenase) and BAN (ANR, anthocyanidin reductase). Anthocyanins 159-172 dihydroflavonol 4-reductase Arabidopsis thaliana 192-195 26070791-2 2015 However, information is scarce about the effects of purple sweet potato (Ipomoea batatas, L.) anthocyanin (PSPA), a class of anthocyanins derived from purple sweet potato roots, on visual health. Anthocyanins 94-105 surfactant protein A2 Homo sapiens 107-111 26070791-2 2015 However, information is scarce about the effects of purple sweet potato (Ipomoea batatas, L.) anthocyanin (PSPA), a class of anthocyanins derived from purple sweet potato roots, on visual health. Anthocyanins 125-137 surfactant protein A2 Homo sapiens 107-111 26109181-9 2015 CONCLUSION: We conclude that the Tc-MYBPA gene that encodes an R2R3 type MYB transcription factor is an Arabidopsis TT2 like transcription factor, and may be involved in the regulation of both anthocyanin and PA synthesis in cacao. Anthocyanins 193-204 Duplicated homeodomain-like superfamily protein Arabidopsis thaliana 116-119 25504198-2 2015 This study characterized four anthocyanidin synthase (ANS) genes of Brassica rapa, a structural gene of the anthocyanin biosynthetic pathway, and investigated their association with pigment formation, cold and freezing tolerance in B. rapa. Anthocyanins 108-119 leucoanthocyanidin dioxygenase Brassica rapa 30-52 25787755-0 2015 Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells. Anthocyanins 0-12 interleukin 6 Homo sapiens 84-88 25896368-1 2015 The MybA1 gene in the genus Vitis encodes a transcription factor, belonging to the R2R3 Myb family, that controls the last steps in the anthocyanins biosynthesis pathway. Anthocyanins 136-148 MYBA1 Vitis vinifera 4-9 25896368-12 2015 Finally, the evolutionary events described could be useful to gain more insight into the role of MybA1 for anthocyanin biosynthesis in grapevine. Anthocyanins 107-118 MYBA1 Vitis vinifera 97-102 25787755-0 2015 Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells. Anthocyanins 0-12 vascular cell adhesion molecule 1 Homo sapiens 93-99 25787755-0 2015 Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells. Anthocyanins 0-12 CD40 ligand Homo sapiens 103-108 25787755-4 2015 In oxLDL-stimulated cells the parent anthocyanin had no effect on IL-6 production, whereas numerous anthocyanin metabolites significantly reduced IL-6 protein levels; phase II conjugates of protocatechuic acid produced the greatest effects (>75% reduction, p <= 0.05). Anthocyanins 100-111 interleukin 6 Homo sapiens 146-150 25787755-5 2015 In CD40L-stimulated cells the anthocyanin and its phase II metabolites reduced IL-6 protein production, where protocatechuic acid-4-sulfate induced the greatest reduction (>96% reduction, p <= 0.03). Anthocyanins 30-41 CD40 ligand Homo sapiens 3-8 25787755-5 2015 In CD40L-stimulated cells the anthocyanin and its phase II metabolites reduced IL-6 protein production, where protocatechuic acid-4-sulfate induced the greatest reduction (>96% reduction, p <= 0.03). Anthocyanins 30-41 interleukin 6 Homo sapiens 79-83 25787755-6 2015 Similarly, the anthocyanin and its metabolites reduced VCAM-1 protein production, with ferulic acid producing the greatest effect (>65% reduction, p <= 0.04). Anthocyanins 15-26 vascular cell adhesion molecule 1 Homo sapiens 55-61 24916164-2 2015 The anthocyanin pathway is regulated by a common set of TFs (MYB, MYC and WD40) belonging to specific families of DNA-binding proteins. Anthocyanins 4-15 MYB proto-oncogene, transcription factor Homo sapiens 61-64 25962102-0 2015 The Anthocyanin Delphinidin 3-Rutinoside Stimulates Glucagon-Like Peptide-1 Secretion in Murine GLUTag Cell Line via the Ca2+/Calmodulin-Dependent Kinase II Pathway. Anthocyanins 4-15 glucagon Mus musculus 52-75 25962102-3 2015 Here, we hypothesized that anthocyanins induce GLP-1 secretion and thereby significantly contribute to the prevention and treatment of diabetes. Anthocyanins 27-39 glucagon Mus musculus 47-52 25962102-12 2015 These findings provide a possible molecular mechanism of GLP-1 secretion in intestinal L-cells mediated by foods or drugs and demonstrate a novel biological function of anthocyanins in regards to GLP-1 secretion. Anthocyanins 169-181 glucagon Mus musculus 196-201 26054672-0 2015 Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2-ARE as an indicator and modulator of redox. Anthocyanins 24-36 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 26054672-7 2015 This review highlights the gene expression induced by dietary anthocyanin via Nrf2 signaling on redox-regulated transcription factor in atherosclerosis disorders. Anthocyanins 62-73 NFE2 like bZIP transcription factor 2 Homo sapiens 78-82 24916164-2 2015 The anthocyanin pathway is regulated by a common set of TFs (MYB, MYC and WD40) belonging to specific families of DNA-binding proteins. Anthocyanins 4-15 MYC proto-oncogene, bHLH transcription factor Homo sapiens 66-69 25997043-2 2015 Anthocyanin, a member of the flavonoid family, has been shown to ameliorate NAFLD-associated pathologies in rodents.The aim of this CONSORT-compliant pilot study is to evaluate the effects of anthocyanin supplementation on insulin resistance and liver injury biomarkers in patients with NAFLD.A total of 74 subjects with NAFLD were divided into 2 groups in this double-blind, randomized study. Anthocyanins 0-11 insulin Homo sapiens 223-230 25997043-5 2015 Compared to controls, the anthocyanin group exhibited significant decreases (P < 0.05, all comparisons) in plasma alanine aminotransferase (-19.1% vs 3.1%), cytokeratin-18 M30 fragment (-8.8% vs 5.6%) and myeloperoxidase (-75.0% vs -44.8%). Anthocyanins 26-37 keratin 18 Homo sapiens 160-174 25997043-5 2015 Compared to controls, the anthocyanin group exhibited significant decreases (P < 0.05, all comparisons) in plasma alanine aminotransferase (-19.1% vs 3.1%), cytokeratin-18 M30 fragment (-8.8% vs 5.6%) and myeloperoxidase (-75.0% vs -44.8%). Anthocyanins 26-37 myeloperoxidase Homo sapiens 208-223 25997043-6 2015 Significant decreases from baseline in fasting blood glucose and homeostasis model assessment for insulin resistance were observed in the anthocyanin group; however, these differences were not significant relative to placebo controls. Anthocyanins 138-149 insulin Homo sapiens 98-105 25997043-7 2015 In addition, the oral glucose tolerance test indicated that anthocyanin supplementation significantly decreased the 2-hour loading glucose level compared to control (-18.7% vs -3.8%, P = 0.02).A 12-week supplement of purified anthocyanin improved insulin resistance, indicators of liver injury, and clinical evolution in NAFLD patients. Anthocyanins 60-71 insulin Homo sapiens 247-254 25749732-5 2015 On the other hand, the loss of tocopherol in vte1 mutants was compensated by the increase of zeaxanthin and anthocyanin contents, which armed vte1 mutants with higher heat dissipation capacity in PS II and higher antioxidative capacity than vtc mutants. Anthocyanins 108-119 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 142-146 25604992-0 2015 Identification of genes that may regulate the expression of the transcription factor production of anthocyanin pigment 1 (PAP1)/MYB75 involved in Arabidopsis anthocyanin biosynthesis. Anthocyanins 99-110 production of anthocyanin pigment 1 Arabidopsis thaliana 122-126 25758596-4 2015 The objective of this study was to determine whether an anthocyanin-rich black elderberry extract (Sambucus nigra) (BEE) (13% anthocyanins) would protect against inflammation-related impairments in HDL function and atherosclerosis in apoE(-/-) mice, a mouse model of hyperlipidemia and HDL dysfunction. Anthocyanins 56-67 apolipoprotein E Mus musculus 234-238 25604992-0 2015 Identification of genes that may regulate the expression of the transcription factor production of anthocyanin pigment 1 (PAP1)/MYB75 involved in Arabidopsis anthocyanin biosynthesis. Anthocyanins 99-110 production of anthocyanin pigment 1 Arabidopsis thaliana 128-133 25604992-1 2015 KEY MESSAGE: A putative RNA-binding protein with a single RNA Recognition Motif (At3G63450) is involved in anthocyanin biosynthesis via its ability to modulate the transcript level of a major positive regulator PAP1 in Arabidopsis. Anthocyanins 107-118 production of anthocyanin pigment 1 Arabidopsis thaliana 211-215 25604992-2 2015 The R2R3 MYB-activator production of anthocyanin pigment 1 (PAP1)/MYB75 plays a major role in anthocyanin biosynthesis in Arabidopsis in combination with one of three bHLH activators including transparent test 8 (TT8), enhancer of glabra3 (EGL3), glabra3 (GL3), and the WD-repeat transcription factor transparent testa 1 (TTG1), forming ternary MYB-basic HLH-WD40 complexes. Anthocyanins 37-48 production of anthocyanin pigment 1 Arabidopsis thaliana 60-64 25604992-2 2015 The R2R3 MYB-activator production of anthocyanin pigment 1 (PAP1)/MYB75 plays a major role in anthocyanin biosynthesis in Arabidopsis in combination with one of three bHLH activators including transparent test 8 (TT8), enhancer of glabra3 (EGL3), glabra3 (GL3), and the WD-repeat transcription factor transparent testa 1 (TTG1), forming ternary MYB-basic HLH-WD40 complexes. Anthocyanins 37-48 production of anthocyanin pigment 1 Arabidopsis thaliana 66-71 25604992-2 2015 The R2R3 MYB-activator production of anthocyanin pigment 1 (PAP1)/MYB75 plays a major role in anthocyanin biosynthesis in Arabidopsis in combination with one of three bHLH activators including transparent test 8 (TT8), enhancer of glabra3 (EGL3), glabra3 (GL3), and the WD-repeat transcription factor transparent testa 1 (TTG1), forming ternary MYB-basic HLH-WD40 complexes. Anthocyanins 37-48 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 213-216 25604992-2 2015 The R2R3 MYB-activator production of anthocyanin pigment 1 (PAP1)/MYB75 plays a major role in anthocyanin biosynthesis in Arabidopsis in combination with one of three bHLH activators including transparent test 8 (TT8), enhancer of glabra3 (EGL3), glabra3 (GL3), and the WD-repeat transcription factor transparent testa 1 (TTG1), forming ternary MYB-basic HLH-WD40 complexes. Anthocyanins 37-48 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 231-238 25604992-2 2015 The R2R3 MYB-activator production of anthocyanin pigment 1 (PAP1)/MYB75 plays a major role in anthocyanin biosynthesis in Arabidopsis in combination with one of three bHLH activators including transparent test 8 (TT8), enhancer of glabra3 (EGL3), glabra3 (GL3), and the WD-repeat transcription factor transparent testa 1 (TTG1), forming ternary MYB-basic HLH-WD40 complexes. Anthocyanins 37-48 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 240-244 25604992-2 2015 The R2R3 MYB-activator production of anthocyanin pigment 1 (PAP1)/MYB75 plays a major role in anthocyanin biosynthesis in Arabidopsis in combination with one of three bHLH activators including transparent test 8 (TT8), enhancer of glabra3 (EGL3), glabra3 (GL3), and the WD-repeat transcription factor transparent testa 1 (TTG1), forming ternary MYB-basic HLH-WD40 complexes. Anthocyanins 37-48 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 247-254 25604992-2 2015 The R2R3 MYB-activator production of anthocyanin pigment 1 (PAP1)/MYB75 plays a major role in anthocyanin biosynthesis in Arabidopsis in combination with one of three bHLH activators including transparent test 8 (TT8), enhancer of glabra3 (EGL3), glabra3 (GL3), and the WD-repeat transcription factor transparent testa 1 (TTG1), forming ternary MYB-basic HLH-WD40 complexes. Anthocyanins 37-48 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 241-244 25604992-2 2015 The R2R3 MYB-activator production of anthocyanin pigment 1 (PAP1)/MYB75 plays a major role in anthocyanin biosynthesis in Arabidopsis in combination with one of three bHLH activators including transparent test 8 (TT8), enhancer of glabra3 (EGL3), glabra3 (GL3), and the WD-repeat transcription factor transparent testa 1 (TTG1), forming ternary MYB-basic HLH-WD40 complexes. Anthocyanins 37-48 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 322-326 25690135-16 2015 ACN extract and M3G significantly attenuated TNF-alpha-stimulated low-grade leukocyte adhesion, expression of adhesion molecules E-selectin, VCAM-1 and ICAM-1 and cytokine expression and secretion (IL-8 and IL-6) as well as NF-kappaB mRNA expression. Anthocyanins 0-3 tumor necrosis factor Homo sapiens 45-54 25690135-16 2015 ACN extract and M3G significantly attenuated TNF-alpha-stimulated low-grade leukocyte adhesion, expression of adhesion molecules E-selectin, VCAM-1 and ICAM-1 and cytokine expression and secretion (IL-8 and IL-6) as well as NF-kappaB mRNA expression. Anthocyanins 0-3 selectin E Homo sapiens 129-139 25690135-16 2015 ACN extract and M3G significantly attenuated TNF-alpha-stimulated low-grade leukocyte adhesion, expression of adhesion molecules E-selectin, VCAM-1 and ICAM-1 and cytokine expression and secretion (IL-8 and IL-6) as well as NF-kappaB mRNA expression. Anthocyanins 0-3 vascular cell adhesion molecule 1 Homo sapiens 141-147 25690135-16 2015 ACN extract and M3G significantly attenuated TNF-alpha-stimulated low-grade leukocyte adhesion, expression of adhesion molecules E-selectin, VCAM-1 and ICAM-1 and cytokine expression and secretion (IL-8 and IL-6) as well as NF-kappaB mRNA expression. Anthocyanins 0-3 intercellular adhesion molecule 1 Homo sapiens 152-158 25690135-16 2015 ACN extract and M3G significantly attenuated TNF-alpha-stimulated low-grade leukocyte adhesion, expression of adhesion molecules E-selectin, VCAM-1 and ICAM-1 and cytokine expression and secretion (IL-8 and IL-6) as well as NF-kappaB mRNA expression. Anthocyanins 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 198-202 25690135-16 2015 ACN extract and M3G significantly attenuated TNF-alpha-stimulated low-grade leukocyte adhesion, expression of adhesion molecules E-selectin, VCAM-1 and ICAM-1 and cytokine expression and secretion (IL-8 and IL-6) as well as NF-kappaB mRNA expression. Anthocyanins 0-3 interleukin 6 Homo sapiens 207-211 25632845-11 2015 Furthermore, ANT restored the levels of IL-10. Anthocyanins 13-16 interleukin 10 Rattus norvegicus 40-45 25833778-0 2015 Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. Anthocyanins 9-20 insulin Homo sapiens 103-110 25833778-3 2015 OBJECTIVE: This study was designed to investigate the effects of purified anthocyanins on dyslipidemia, oxidative status, and insulin sensitivity in patients with type 2 diabetes. Anthocyanins 74-86 insulin Homo sapiens 126-133 25833778-9 2015 Furthermore, supplementation with anthocyanin lowered fasting plasma glucose (by 8.5%; P < 0.05) and homeostasis model assessment for insulin resistance index (by 13%; P < 0.05), and elevated serum adiponectin (by 23.4%; P < 0.01) and beta-hydroxybutyrate (by 42.4%; P = 0.01) concentrations compared with placebo supplementation. Anthocyanins 34-45 insulin Homo sapiens 137-144 25833778-9 2015 Furthermore, supplementation with anthocyanin lowered fasting plasma glucose (by 8.5%; P < 0.05) and homeostasis model assessment for insulin resistance index (by 13%; P < 0.05), and elevated serum adiponectin (by 23.4%; P < 0.01) and beta-hydroxybutyrate (by 42.4%; P = 0.01) concentrations compared with placebo supplementation. Anthocyanins 34-45 adiponectin, C1Q and collagen domain containing Homo sapiens 204-215 25833778-10 2015 CONCLUSION: These findings demonstrate that anthocyanin supplementation exerts beneficial metabolic effects in subjects with type 2 diabetes by improving dyslipidemia, enhancing antioxidant capacity, and preventing insulin resistance. Anthocyanins 44-55 insulin Homo sapiens 215-222 25425527-0 2015 Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attributable to the ENHANCER OF AG-4 2 (HUA2) locus in combination with PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2. Anthocyanins 22-33 Tudor/PWWP/MBT domain-containing protein Arabidopsis thaliana 114-132 25425527-0 2015 Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attributable to the ENHANCER OF AG-4 2 (HUA2) locus in combination with PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2. Anthocyanins 22-33 Tudor/PWWP/MBT domain-containing protein Arabidopsis thaliana 134-138 25425527-0 2015 Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attributable to the ENHANCER OF AG-4 2 (HUA2) locus in combination with PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2. Anthocyanins 22-33 production of anthocyanin pigment 1 Arabidopsis thaliana 166-200 25425527-0 2015 Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attributable to the ENHANCER OF AG-4 2 (HUA2) locus in combination with PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2. Anthocyanins 22-33 production of anthocyanin pigment 1 Arabidopsis thaliana 202-206 25425527-0 2015 Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attributable to the ENHANCER OF AG-4 2 (HUA2) locus in combination with PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2. Anthocyanins 22-33 Purple acid phosphatases superfamily protein Arabidopsis thaliana 212-216 25425527-6 2015 Several QTLs were found for FT and for anthocyanin content, of which one QTL co-located at the ENHANCER OF AG-4 2 (HUA2) locus. Anthocyanins 39-50 Tudor/PWWP/MBT domain-containing protein Arabidopsis thaliana 95-113 25425527-6 2015 Several QTLs were found for FT and for anthocyanin content, of which one QTL co-located at the ENHANCER OF AG-4 2 (HUA2) locus. Anthocyanins 39-50 Tudor/PWWP/MBT domain-containing protein Arabidopsis thaliana 115-119 25425527-8 2015 For a strong expression of anthocyanin, additional allelic variation was detected for the PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2 genes which control the anthocyanin pathway. Anthocyanins 27-38 production of anthocyanin pigment 1 Arabidopsis thaliana 90-124 25425527-8 2015 For a strong expression of anthocyanin, additional allelic variation was detected for the PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2 genes which control the anthocyanin pathway. Anthocyanins 27-38 production of anthocyanin pigment 1 Arabidopsis thaliana 126-130 25425527-8 2015 For a strong expression of anthocyanin, additional allelic variation was detected for the PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2 genes which control the anthocyanin pathway. Anthocyanins 27-38 Purple acid phosphatases superfamily protein Arabidopsis thaliana 136-140 25425527-8 2015 For a strong expression of anthocyanin, additional allelic variation was detected for the PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2 genes which control the anthocyanin pathway. Anthocyanins 165-176 production of anthocyanin pigment 1 Arabidopsis thaliana 90-124 25425527-8 2015 For a strong expression of anthocyanin, additional allelic variation was detected for the PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2 genes which control the anthocyanin pathway. Anthocyanins 165-176 production of anthocyanin pigment 1 Arabidopsis thaliana 126-130 25425527-8 2015 For a strong expression of anthocyanin, additional allelic variation was detected for the PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2 genes which control the anthocyanin pathway. Anthocyanins 165-176 Purple acid phosphatases superfamily protein Arabidopsis thaliana 136-140 25156080-10 2015 Loss of pigmentation may result from reduced expression of the Myb-bHLH-WD40 anthocyanin regulatory complex--a possible candidate might be the bHLH transcription factor JAF13. Anthocyanins 77-88 transcription factor TT8-like Solanum tuberosum 67-71 25156080-10 2015 Loss of pigmentation may result from reduced expression of the Myb-bHLH-WD40 anthocyanin regulatory complex--a possible candidate might be the bHLH transcription factor JAF13. Anthocyanins 77-88 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 72-76 25156080-10 2015 Loss of pigmentation may result from reduced expression of the Myb-bHLH-WD40 anthocyanin regulatory complex--a possible candidate might be the bHLH transcription factor JAF13. Anthocyanins 77-88 transcription factor TT8-like Solanum tuberosum 143-147 25156080-10 2015 Loss of pigmentation may result from reduced expression of the Myb-bHLH-WD40 anthocyanin regulatory complex--a possible candidate might be the bHLH transcription factor JAF13. Anthocyanins 77-88 transcription factor GLABRA 3-like Solanum tuberosum 169-174 25256341-0 2015 Transcription coactivator Arabidopsis ANGUSTIFOLIA3 modulates anthocyanin accumulation and light-induced root elongation through transrepression of Constitutive Photomorphogenic1. Anthocyanins 62-73 SSXT family protein Arabidopsis thaliana 38-51 25256341-2 2015 In this study, I found that AN3 is a novel regulator of anthocyanin biosynthesis and light-induced root elongation. Anthocyanins 56-67 SSXT family protein Arabidopsis thaliana 28-31 25256341-3 2015 Seedlings and seeds lacking AN3 activity presented significantly reduced anthocyanin accumulation and light-induced root elongation, whereas those of transgenic plants harbouring the 35S:AN3 construct exhibited increased anthocyanin accumulation. Anthocyanins 73-84 SSXT family protein Arabidopsis thaliana 28-31 25256341-3 2015 Seedlings and seeds lacking AN3 activity presented significantly reduced anthocyanin accumulation and light-induced root elongation, whereas those of transgenic plants harbouring the 35S:AN3 construct exhibited increased anthocyanin accumulation. Anthocyanins 221-232 SSXT family protein Arabidopsis thaliana 187-190 25256341-4 2015 AN3 is required for the proper expression of other genes that affect anthocyanin accumulation and light-induced root elongation, Constitutive Photomorphogenic1 (COP1), encoding a RING motif - containing E3 ubiquitin ligase. Anthocyanins 69-80 SSXT family protein Arabidopsis thaliana 0-3 25256341-6 2015 Thus, AN3 may act with other proteins that bind to COP1 promoter to promote anthocyanin accumulation and inhibit light-induced root elongation. Anthocyanins 76-87 SSXT family protein Arabidopsis thaliana 6-9 25256341-6 2015 Thus, AN3 may act with other proteins that bind to COP1 promoter to promote anthocyanin accumulation and inhibit light-induced root elongation. Anthocyanins 76-87 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 51-55 25659381-5 2015 Conversely, transgenic petunia lines expressing VvMYBC2-L1 and VvMYBC2-L3 showed a severe reduction in petal anthocyanins and seed proanthocyanidins together with a higher pH of crude petal extracts. Anthocyanins 109-121 R2R3 Myb transcription factor C2 repressor motif protein Vitis vinifera 48-58 25681576-8 2015 In addition, RT-PCR analysis revealed that IbMYB1a expression induced the up-regulation of several structural genes in the anthocyanin biosynthetic pathway, including DFR and ANS. Anthocyanins 123-134 dihydroflavonol-4-reductase Nicotiana tabacum 167-170 25698665-1 2015 The R2R3-MYB protein SlAN2 has long been thought to be a positive regulator of anthocyanin accumulation. Anthocyanins 79-90 transcription factor MYB75 Solanum lycopersicum 21-26 25889552-3 2015 The aim of this study was to determine whether the intake of an anthocyanin-rich maqui extract improved H2O2 and IL-6 concentrations in exhaled breath condensates (EBCs) from asymptomatic smokers. Anthocyanins 64-75 interleukin 6 Homo sapiens 113-117 25686009-7 2015 Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. Anthocyanins 0-11 heme oxygenase 1 Homo sapiens 79-83 25653236-0 2015 Direct and indirect inactivation of tumor cell protective catalase by salicylic acid and anthocyanidins reactivates intercellular ROS signaling and allows for synergistic effects. Anthocyanins 89-103 catalase Homo sapiens 58-66 25653236-7 2015 Here, we show that salicylic acid and anthocyanidins inactivate tumor cell protective catalase and thus reactive apoptosis-inducing intercellular reactive oxygen species signaling of tumor cells and the mitochondrial pathway of apoptosis Salicylic acid inhibits catalase directly through its potential to transform compound I of catalase into the inactive compound II. Anthocyanins 38-52 catalase Homo sapiens 86-94 25653236-7 2015 Here, we show that salicylic acid and anthocyanidins inactivate tumor cell protective catalase and thus reactive apoptosis-inducing intercellular reactive oxygen species signaling of tumor cells and the mitochondrial pathway of apoptosis Salicylic acid inhibits catalase directly through its potential to transform compound I of catalase into the inactive compound II. Anthocyanins 38-52 catalase Homo sapiens 262-270 25653236-7 2015 Here, we show that salicylic acid and anthocyanidins inactivate tumor cell protective catalase and thus reactive apoptosis-inducing intercellular reactive oxygen species signaling of tumor cells and the mitochondrial pathway of apoptosis Salicylic acid inhibits catalase directly through its potential to transform compound I of catalase into the inactive compound II. Anthocyanins 38-52 catalase Homo sapiens 262-270 25653236-8 2015 In contrast, anthocyanidins provoke a complex mechanism for catalase inactivation that is initiated by anthocyanidin-mediated inhibition of NO dioxygenase. Anthocyanins 13-27 catalase Homo sapiens 60-68 25653236-8 2015 In contrast, anthocyanidins provoke a complex mechanism for catalase inactivation that is initiated by anthocyanidin-mediated inhibition of NO dioxygenase. Anthocyanins 13-26 catalase Homo sapiens 60-68 25628328-8 2015 Here, a model is proposed for the regulation of the anthocyanin pathway in Solanaceous plants in which AN1 is directly involved in the activation of the biosynthetic genes, whereas JAF13 is involved in the regulation of AN1 transcription. Anthocyanins 52-63 annexin D1-like Nicotiana tabacum 103-106 25578040-6 2015 We evaluated the effects of 21 anthocyanins and their corresponding 6 anthocyanidins on the expression levels of SLCO1B1/SLCO1B3 by RT-qPCR. Anthocyanins 31-43 solute carrier organic anion transporter family member 1B1 Homo sapiens 113-120 25578040-6 2015 We evaluated the effects of 21 anthocyanins and their corresponding 6 anthocyanidins on the expression levels of SLCO1B1/SLCO1B3 by RT-qPCR. Anthocyanins 31-43 solute carrier organic anion transporter family member 1B3 Homo sapiens 121-128 25578040-6 2015 We evaluated the effects of 21 anthocyanins and their corresponding 6 anthocyanidins on the expression levels of SLCO1B1/SLCO1B3 by RT-qPCR. Anthocyanins 70-84 solute carrier organic anion transporter family member 1B1 Homo sapiens 113-120 25578040-6 2015 We evaluated the effects of 21 anthocyanins and their corresponding 6 anthocyanidins on the expression levels of SLCO1B1/SLCO1B3 by RT-qPCR. Anthocyanins 70-84 solute carrier organic anion transporter family member 1B3 Homo sapiens 121-128 25628328-8 2015 Here, a model is proposed for the regulation of the anthocyanin pathway in Solanaceous plants in which AN1 is directly involved in the activation of the biosynthetic genes, whereas JAF13 is involved in the regulation of AN1 transcription. Anthocyanins 52-63 annexin D1-like Nicotiana tabacum 220-223 25573539-2 2015 Limited epidemiological and animal data suggest that flavonoids, and specifically anthocyanins, may increase EPA and DHA levels, potentially by increasing their synthesis from the shorter-chain n-3 PUFA, alpha-linolenic acid. Anthocyanins 82-94 pumilio RNA binding family member 3 Homo sapiens 198-202 25659750-4 2015 Here the GL3 and EGL3 proteins were characterized with respect to their affinities for PRODUCTION OF ANTHOCYANIN PIGMENT2 (PAP2), a R2R3-MYB which is induced by nitrogen depletion and is part of MBW complexes promoting anthocyanin synthesis. Anthocyanins 219-230 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 9-12 25437348-1 2015 LeAN2 is an anthocyanin-associated R2R3-MYB transcription factor, but little is known about its function in imparting thermo-tolerance to higher plants. Anthocyanins 12-23 transcription factor MYB117 Solanum lycopersicum 35-43 25659750-1 2015 The two Arabidopsis basic-helix-loop-helix transcription factors GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) are positive regulators of anthocyanin biosynthesis, and form protein complexes (MBW complexes) with various R2R3 MYB transcription factors and a WD40 repeat protein TRANSPARENT TESTA GLABROUS1 (TTG1). Anthocyanins 137-148 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 65-72 25659750-1 2015 The two Arabidopsis basic-helix-loop-helix transcription factors GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) are positive regulators of anthocyanin biosynthesis, and form protein complexes (MBW complexes) with various R2R3 MYB transcription factors and a WD40 repeat protein TRANSPARENT TESTA GLABROUS1 (TTG1). Anthocyanins 137-148 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 74-77 25659750-1 2015 The two Arabidopsis basic-helix-loop-helix transcription factors GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) are positive regulators of anthocyanin biosynthesis, and form protein complexes (MBW complexes) with various R2R3 MYB transcription factors and a WD40 repeat protein TRANSPARENT TESTA GLABROUS1 (TTG1). Anthocyanins 137-148 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 83-102 25659750-1 2015 The two Arabidopsis basic-helix-loop-helix transcription factors GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) are positive regulators of anthocyanin biosynthesis, and form protein complexes (MBW complexes) with various R2R3 MYB transcription factors and a WD40 repeat protein TRANSPARENT TESTA GLABROUS1 (TTG1). Anthocyanins 137-148 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 104-108 25659750-1 2015 The two Arabidopsis basic-helix-loop-helix transcription factors GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) are positive regulators of anthocyanin biosynthesis, and form protein complexes (MBW complexes) with various R2R3 MYB transcription factors and a WD40 repeat protein TRANSPARENT TESTA GLABROUS1 (TTG1). Anthocyanins 137-148 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 305-309 25659750-2 2015 In earlier studies, GL3, in contrast to EGL3, was shown to be essential for accumulation of anthocyanins in response to nitrogen depletion. Anthocyanins 92-104 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 20-23 25557610-6 2015 Many in vitro and in vivo studies also reveal an array of mechanisms through which anthocyanins could prevent or reverse obesity- and T2DM-related pathologies including promotion of antioxidant and anti-inflammatory activities, improvement of insulin resistance, and hypolipidemic and hypoglycemic actions. Anthocyanins 83-95 insulin Homo sapiens 243-250 25533330-2 2015 We have shown that treatment of reconstituted human skin with delphinidin, an anthocyanidin, present in pigmented fruits and vegetables, increased the expression and processing of caspase-14, which is involved in cornification. Anthocyanins 78-91 caspase 14 Homo sapiens 180-190 25659750-4 2015 Here the GL3 and EGL3 proteins were characterized with respect to their affinities for PRODUCTION OF ANTHOCYANIN PIGMENT2 (PAP2), a R2R3-MYB which is induced by nitrogen depletion and is part of MBW complexes promoting anthocyanin synthesis. Anthocyanins 219-230 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 17-21 25659750-4 2015 Here the GL3 and EGL3 proteins were characterized with respect to their affinities for PRODUCTION OF ANTHOCYANIN PIGMENT2 (PAP2), a R2R3-MYB which is induced by nitrogen depletion and is part of MBW complexes promoting anthocyanin synthesis. Anthocyanins 219-230 myb domain protein 90 Arabidopsis thaliana 87-121 25659750-4 2015 Here the GL3 and EGL3 proteins were characterized with respect to their affinities for PRODUCTION OF ANTHOCYANIN PIGMENT2 (PAP2), a R2R3-MYB which is induced by nitrogen depletion and is part of MBW complexes promoting anthocyanin synthesis. Anthocyanins 219-230 myb domain protein 90 Arabidopsis thaliana 123-127 25659750-5 2015 GL3 and EGL3 were also tested for their binding to MYBL2, a negative regulator of anthocyanin synthesis and MBW complexes. Anthocyanins 82-93 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 0-3 25659750-5 2015 GL3 and EGL3 were also tested for their binding to MYBL2, a negative regulator of anthocyanin synthesis and MBW complexes. Anthocyanins 82-93 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 8-12 25659750-5 2015 GL3 and EGL3 were also tested for their binding to MYBL2, a negative regulator of anthocyanin synthesis and MBW complexes. Anthocyanins 82-93 MYB-like 2 Arabidopsis thaliana 51-56 25659750-8 2015 In transgenic plants where EGL3 reaches high concentrations compared with MYBL2 the equilibrium is shifted and MYBL2 is not likely to be an efficient competitor, hence anthocyanin formation could be restored by either EGL3 or GL3 genes when overexpressed by help of the 35S promoter. Anthocyanins 168-179 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 27-31 25659750-8 2015 In transgenic plants where EGL3 reaches high concentrations compared with MYBL2 the equilibrium is shifted and MYBL2 is not likely to be an efficient competitor, hence anthocyanin formation could be restored by either EGL3 or GL3 genes when overexpressed by help of the 35S promoter. Anthocyanins 168-179 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 218-222 25659750-9 2015 The present work underpins that GL3 is essential for anthocyanin accumulation under nitrogen depletion not only due to transcriptional activation, but also because of binding properties to proteins promoting or inhibiting the activity of the MBW complex. Anthocyanins 53-64 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 32-35 25536170-4 2015 Furthermore, anthocyanins treatment promoted activation of AMP-activated protein kinase (AMPK) and expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha). Anthocyanins 13-25 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 113-180 25536170-4 2015 Furthermore, anthocyanins treatment promoted activation of AMP-activated protein kinase (AMPK) and expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha). Anthocyanins 13-25 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 182-192 25536170-5 2015 These data provide evidence that anthocyanins possess significant protective effects against NASH and mitochondrial defects in response to a MCD diet, with a mechanism maybe through affecting the AMPK/PGC-1alpha signaling pathways. Anthocyanins 33-45 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 201-211 26238538-5 2015 In this study, we tested the hypothesis that a mixture of anthocyanins/anthocyanidins presents in the formulation MAF14001 may mitigate the amyloid-beta peptide (Abeta) toxicity. Anthocyanins 58-70 amyloid beta precursor protein Homo sapiens 162-167 26649302-0 2015 Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway. Anthocyanins 11-23 zinc fingers and homeoboxes 2 Homo sapiens 84-87 26238538-5 2015 In this study, we tested the hypothesis that a mixture of anthocyanins/anthocyanidins presents in the formulation MAF14001 may mitigate the amyloid-beta peptide (Abeta) toxicity. Anthocyanins 71-85 amyloid beta precursor protein Homo sapiens 162-167 25714970-7 2015 Consequently, anthocyanins also decreased the expression of poly (ADP ribose) polymerase-1 induced by ethanol and prevented DNA damage. Anthocyanins 14-26 poly (ADP-ribose) polymerase 1 Rattus norvegicus 60-90 25932661-0 2015 Barley Ant17, encoding flavanone 3-hydroxylase (F3H), is a promising target locus for attaining anthocyanin/proanthocyanidin-free plants without pleiotropic reduction of grain dormancy. Anthocyanins 96-107 LOC100191101 Hordeum vulgare 23-46 25932661-0 2015 Barley Ant17, encoding flavanone 3-hydroxylase (F3H), is a promising target locus for attaining anthocyanin/proanthocyanidin-free plants without pleiotropic reduction of grain dormancy. Anthocyanins 96-107 LOC100191101 Hordeum vulgare 48-51 26582155-11 2015 These results suggest that anthocyanin-rich phytochemicals in aronia fruits suppress visceral fat accumulation and hyperglycemia by inhibiting pancreatic lipase activity and/or intestinal lipid absorption. Anthocyanins 27-38 pancreatic lipase Rattus norvegicus 143-160 24997566-6 2015 The results suggest that anthocyanins significantly reversed the ethanol-induced inhibition of glutamatergic neurotransmission, synaptic dysfunction, GABAB1R activation, and neuronal apoptosis by stimulating the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/v-akt murine thymoma viral oncogene (Akt)/glycogen synthase kinase 3 beta (GSK3beta) pathway in the hippocampus of postnatal rat brain. Anthocyanins 25-37 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 212-258 24997566-6 2015 The results suggest that anthocyanins significantly reversed the ethanol-induced inhibition of glutamatergic neurotransmission, synaptic dysfunction, GABAB1R activation, and neuronal apoptosis by stimulating the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/v-akt murine thymoma viral oncogene (Akt)/glycogen synthase kinase 3 beta (GSK3beta) pathway in the hippocampus of postnatal rat brain. Anthocyanins 25-37 thymoma viral proto-oncogene 1 Mus musculus 268-271 24997566-6 2015 The results suggest that anthocyanins significantly reversed the ethanol-induced inhibition of glutamatergic neurotransmission, synaptic dysfunction, GABAB1R activation, and neuronal apoptosis by stimulating the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/v-akt murine thymoma viral oncogene (Akt)/glycogen synthase kinase 3 beta (GSK3beta) pathway in the hippocampus of postnatal rat brain. Anthocyanins 25-37 thymoma viral proto-oncogene 1 Mus musculus 303-306 24997566-6 2015 The results suggest that anthocyanins significantly reversed the ethanol-induced inhibition of glutamatergic neurotransmission, synaptic dysfunction, GABAB1R activation, and neuronal apoptosis by stimulating the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/v-akt murine thymoma viral oncogene (Akt)/glycogen synthase kinase 3 beta (GSK3beta) pathway in the hippocampus of postnatal rat brain. Anthocyanins 25-37 glycogen synthase kinase 3 beta Mus musculus 308-339 24997566-6 2015 The results suggest that anthocyanins significantly reversed the ethanol-induced inhibition of glutamatergic neurotransmission, synaptic dysfunction, GABAB1R activation, and neuronal apoptosis by stimulating the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/v-akt murine thymoma viral oncogene (Akt)/glycogen synthase kinase 3 beta (GSK3beta) pathway in the hippocampus of postnatal rat brain. Anthocyanins 25-37 glycogen synthase kinase 3 beta Mus musculus 341-349 24997566-7 2015 Anthocyanins also inhibited the ethanol-activated expression of phosphorylated c-Jun N terminal kinase (p-JNK), phospho-nuclear factor kappa B (p-NF-kappaB), cyclooxygenase 2 (COX-2), as well as attenuating neuronal apoptosis in the hippocampal CA1, CA3 and DG regions of the developing rat brain. Anthocyanins 0-12 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 158-174 24997566-7 2015 Anthocyanins also inhibited the ethanol-activated expression of phosphorylated c-Jun N terminal kinase (p-JNK), phospho-nuclear factor kappa B (p-NF-kappaB), cyclooxygenase 2 (COX-2), as well as attenuating neuronal apoptosis in the hippocampal CA1, CA3 and DG regions of the developing rat brain. Anthocyanins 0-12 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 176-181 24997566-7 2015 Anthocyanins also inhibited the ethanol-activated expression of phosphorylated c-Jun N terminal kinase (p-JNK), phospho-nuclear factor kappa B (p-NF-kappaB), cyclooxygenase 2 (COX-2), as well as attenuating neuronal apoptosis in the hippocampal CA1, CA3 and DG regions of the developing rat brain. Anthocyanins 0-12 carbonic anhydrase 1 Rattus norvegicus 245-248 24997566-7 2015 Anthocyanins also inhibited the ethanol-activated expression of phosphorylated c-Jun N terminal kinase (p-JNK), phospho-nuclear factor kappa B (p-NF-kappaB), cyclooxygenase 2 (COX-2), as well as attenuating neuronal apoptosis in the hippocampal CA1, CA3 and DG regions of the developing rat brain. Anthocyanins 0-12 carbonic anhydrase 3 Rattus norvegicus 250-253 24997566-8 2015 Furthermore, anthocyanins increased cell viability, attenuated ethanol-induced PI3K-dependent ROS production, cytotoxicity, and caspase-3/7 activation in vitro. Anthocyanins 13-25 caspase 3 Rattus norvegicus 128-137 25451757-4 2015 Anthocyanins were treated 0.2 mg/kg in case of cell lines or 4 mg/kg intragastrically to adult rats to protect against Abeta-induced neurodegeneration. Anthocyanins 0-12 amyloid beta precursor protein Rattus norvegicus 119-124 25451757-8 2015 In accordance, anthocyanins reversed Abeta-induced effect on protein expression of mitochondrial apoptotic pathway (Bax, cytochrome C, caspase-9 and caspase-3) and major Alzheimer"s markers i.e. Abeta, APP, P-tau and BACE-1. Anthocyanins 15-27 amyloid beta precursor protein Rattus norvegicus 37-42 25451757-8 2015 In accordance, anthocyanins reversed Abeta-induced effect on protein expression of mitochondrial apoptotic pathway (Bax, cytochrome C, caspase-9 and caspase-3) and major Alzheimer"s markers i.e. Abeta, APP, P-tau and BACE-1. Anthocyanins 15-27 BCL2 associated X, apoptosis regulator Rattus norvegicus 116-119 25451757-8 2015 In accordance, anthocyanins reversed Abeta-induced effect on protein expression of mitochondrial apoptotic pathway (Bax, cytochrome C, caspase-9 and caspase-3) and major Alzheimer"s markers i.e. Abeta, APP, P-tau and BACE-1. Anthocyanins 15-27 caspase 9 Rattus norvegicus 135-144 25451757-8 2015 In accordance, anthocyanins reversed Abeta-induced effect on protein expression of mitochondrial apoptotic pathway (Bax, cytochrome C, caspase-9 and caspase-3) and major Alzheimer"s markers i.e. Abeta, APP, P-tau and BACE-1. Anthocyanins 15-27 caspase 3 Rattus norvegicus 149-158 25451757-8 2015 In accordance, anthocyanins reversed Abeta-induced effect on protein expression of mitochondrial apoptotic pathway (Bax, cytochrome C, caspase-9 and caspase-3) and major Alzheimer"s markers i.e. Abeta, APP, P-tau and BACE-1. Anthocyanins 15-27 amyloid beta precursor protein Rattus norvegicus 195-200 25451757-8 2015 In accordance, anthocyanins reversed Abeta-induced effect on protein expression of mitochondrial apoptotic pathway (Bax, cytochrome C, caspase-9 and caspase-3) and major Alzheimer"s markers i.e. Abeta, APP, P-tau and BACE-1. Anthocyanins 15-27 microtubule-associated protein tau Rattus norvegicus 207-212 25451757-8 2015 In accordance, anthocyanins reversed Abeta-induced effect on protein expression of mitochondrial apoptotic pathway (Bax, cytochrome C, caspase-9 and caspase-3) and major Alzheimer"s markers i.e. Abeta, APP, P-tau and BACE-1. Anthocyanins 15-27 beta-secretase 1 Rattus norvegicus 217-223 25658905-0 2015 Anthocyanins from black rice (Oryza sativa L.) demonstrate antimetastatic properties by reducing MMPs and NF-kappaB expressions in human oral cancer CAL 27 cells. Anthocyanins 0-12 nuclear factor kappa B subunit 1 Homo sapiens 106-115 25658905-6 2015 In addition, the gelatin zymography assay indicated that anthocyanins inhibited the activity of matrix metalloproteinases-2 (MMP-2). Anthocyanins 57-69 matrix metallopeptidase 2 Homo sapiens 96-123 25658905-6 2015 In addition, the gelatin zymography assay indicated that anthocyanins inhibited the activity of matrix metalloproteinases-2 (MMP-2). Anthocyanins 57-69 matrix metallopeptidase 2 Homo sapiens 125-130 25658905-8 2015 Immunofluorescence staining proved that anthocyanins inhibited nuclear factor kappa B p65 (NF-kappaB p65) expressions. Anthocyanins 40-52 RELA proto-oncogene, NF-kB subunit Homo sapiens 63-89 25658905-8 2015 Immunofluorescence staining proved that anthocyanins inhibited nuclear factor kappa B p65 (NF-kappaB p65) expressions. Anthocyanins 40-52 RELA proto-oncogene, NF-kB subunit Homo sapiens 91-104 25658905-9 2015 These results demonstrated that anthocyanins from a species of black rice (selected purple glutinous indica rice cultivated at Asia University) could suppress CAL 27 cell metastasis by reduction of MMP-2, MMP-9, and NF-kappaB p65 expression through the suppression of PI3K/Akt pathway and inhibition of NF-kappaB levels. Anthocyanins 32-44 matrix metallopeptidase 2 Homo sapiens 198-203 25658905-9 2015 These results demonstrated that anthocyanins from a species of black rice (selected purple glutinous indica rice cultivated at Asia University) could suppress CAL 27 cell metastasis by reduction of MMP-2, MMP-9, and NF-kappaB p65 expression through the suppression of PI3K/Akt pathway and inhibition of NF-kappaB levels. Anthocyanins 32-44 matrix metallopeptidase 9 Homo sapiens 205-210 25658905-9 2015 These results demonstrated that anthocyanins from a species of black rice (selected purple glutinous indica rice cultivated at Asia University) could suppress CAL 27 cell metastasis by reduction of MMP-2, MMP-9, and NF-kappaB p65 expression through the suppression of PI3K/Akt pathway and inhibition of NF-kappaB levels. Anthocyanins 32-44 nuclear factor kappa B subunit 1 Homo sapiens 216-225 25658905-9 2015 These results demonstrated that anthocyanins from a species of black rice (selected purple glutinous indica rice cultivated at Asia University) could suppress CAL 27 cell metastasis by reduction of MMP-2, MMP-9, and NF-kappaB p65 expression through the suppression of PI3K/Akt pathway and inhibition of NF-kappaB levels. Anthocyanins 32-44 RELA proto-oncogene, NF-kB subunit Homo sapiens 226-229 25658905-9 2015 These results demonstrated that anthocyanins from a species of black rice (selected purple glutinous indica rice cultivated at Asia University) could suppress CAL 27 cell metastasis by reduction of MMP-2, MMP-9, and NF-kappaB p65 expression through the suppression of PI3K/Akt pathway and inhibition of NF-kappaB levels. Anthocyanins 32-44 AKT serine/threonine kinase 1 Homo sapiens 273-276 25658905-9 2015 These results demonstrated that anthocyanins from a species of black rice (selected purple glutinous indica rice cultivated at Asia University) could suppress CAL 27 cell metastasis by reduction of MMP-2, MMP-9, and NF-kappaB p65 expression through the suppression of PI3K/Akt pathway and inhibition of NF-kappaB levels. Anthocyanins 32-44 nuclear factor kappa B subunit 1 Homo sapiens 303-312 25482806-0 2015 COP1/SPA ubiquitin ligase complexes repress anthocyanin accumulation under low light and high light conditions. Anthocyanins 44-55 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 0-4 25482806-4 2015 Here, we show that mutations in the key repressor of light signaling, the COP1/SPA complex, cause a strong hyperaccumulation of anthocyanins not only under normal light but also under excess, high light conditions. Anthocyanins 128-140 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 74-78 25482806-5 2015 Hence, normal light signaling via COP1/SPA is required to prevent hyperaccumulation of anthocyanins under these high light conditions. Anthocyanins 87-99 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 34-38 25482806-6 2015 However, since cop1 and spa mutants show a similar high-light responsiveness of anthocyanin accumulation as the wild type it remains to be resolved whether COP1/SPA is directly involved in the high-light response itself. Anthocyanins 80-91 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 15-19 26039466-2 2015 CPC and GL3 are involved in root-hair differentiation, trichome initiation and anthocyanin biosynthesis in Arabidopsis epidermal cells. Anthocyanins 79-90 Homeodomain-like superfamily protein Arabidopsis thaliana 0-3 26039466-2 2015 CPC and GL3 are involved in root-hair differentiation, trichome initiation and anthocyanin biosynthesis in Arabidopsis epidermal cells. Anthocyanins 79-90 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 8-11 26039466-3 2015 Previously, we showed that CPC and GL3 also influence anthocyanin accumulation in tomato. Anthocyanins 54-65 Homeodomain-like superfamily protein Arabidopsis thaliana 27-30 26039466-3 2015 Previously, we showed that CPC and GL3 also influence anthocyanin accumulation in tomato. Anthocyanins 54-65 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 35-38 26039466-4 2015 Introduction of 35S::CPC into tomato significantly inhibits anthocyanin accumulation in cotyledons, leaves and stems. Anthocyanins 60-71 Homeodomain-like superfamily protein Arabidopsis thaliana 21-24 26039466-5 2015 In contrast, introduction of GL3::GL3 strongly enhances anthocyanin accumulation in cotyledons, leaves and stems of tomato. Anthocyanins 56-67 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 29-32 26039466-5 2015 In contrast, introduction of GL3::GL3 strongly enhances anthocyanin accumulation in cotyledons, leaves and stems of tomato. Anthocyanins 56-67 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 34-37 26039466-6 2015 In this study, we investigated the effect of CPC and GL3 on anthocyanin accumulation in the epidermis of tomato fruit. Anthocyanins 60-71 Homeodomain-like superfamily protein Arabidopsis thaliana 45-48 26039466-6 2015 In this study, we investigated the effect of CPC and GL3 on anthocyanin accumulation in the epidermis of tomato fruit. Anthocyanins 60-71 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 53-56 26357851-0 2015 Light signaling induces anthocyanin biosynthesis via AN3 mediated COP1 expression. Anthocyanins 24-35 SSXT family protein Arabidopsis thaliana 53-56 26357851-0 2015 Light signaling induces anthocyanin biosynthesis via AN3 mediated COP1 expression. Anthocyanins 24-35 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 66-70 26357851-5 2015 Here, we briefly review the recent progress on the light-triggered anthocyanin biosynthesis via ANGUSTIFOLIA3 (AN3) and CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) network in Arabidopsis. Anthocyanins 67-78 SSXT family protein Arabidopsis thaliana 96-109 26357851-5 2015 Here, we briefly review the recent progress on the light-triggered anthocyanin biosynthesis via ANGUSTIFOLIA3 (AN3) and CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) network in Arabidopsis. Anthocyanins 67-78 SSXT family protein Arabidopsis thaliana 111-114 26357851-5 2015 Here, we briefly review the recent progress on the light-triggered anthocyanin biosynthesis via ANGUSTIFOLIA3 (AN3) and CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) network in Arabidopsis. Anthocyanins 67-78 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 152-156 25385333-9 2015 Analysis of a set of 714 inbred lines demonstrated that a combination of two gene-specific markers--8 bp C1-I InDel and C1-I SNP--could predict with high accuracy the presence of anthocyanin color inhibition in the germplasm analyzed. Anthocyanins 179-190 anthocyanin regulatory C1 protein Zea mays 105-109 25385333-9 2015 Analysis of a set of 714 inbred lines demonstrated that a combination of two gene-specific markers--8 bp C1-I InDel and C1-I SNP--could predict with high accuracy the presence of anthocyanin color inhibition in the germplasm analyzed. Anthocyanins 179-190 anthocyanin regulatory C1 protein Zea mays 120-124 25108127-2 2014 Dihydroflavonol 4-reductase (DFR) is part of an important step in the flavonoid biosynthetic pathway of anthocyanins. Anthocyanins 104-116 dihydroflavonol 4-reductase Brassica rapa 0-27 25450360-2 2014 It is shown that the expression of genes encoding the key enzymes such as dihydroflavonol 4-reductase (DFR), UDP-Glc: flavonoid 3-O-glucosyltransferase (UF3GT), and leucoanthocyanidin dioxygenase (LDOX) in anthocyanin biosynthesis pathway is regulated by MYB75, a R2R3 MYB transcription factor. Anthocyanins 206-217 dihydroflavonol 4-reductase Arabidopsis thaliana 74-101 25450360-2 2014 It is shown that the expression of genes encoding the key enzymes such as dihydroflavonol 4-reductase (DFR), UDP-Glc: flavonoid 3-O-glucosyltransferase (UF3GT), and leucoanthocyanidin dioxygenase (LDOX) in anthocyanin biosynthesis pathway is regulated by MYB75, a R2R3 MYB transcription factor. Anthocyanins 206-217 dihydroflavonol 4-reductase Arabidopsis thaliana 103-106 25450360-2 2014 It is shown that the expression of genes encoding the key enzymes such as dihydroflavonol 4-reductase (DFR), UDP-Glc: flavonoid 3-O-glucosyltransferase (UF3GT), and leucoanthocyanidin dioxygenase (LDOX) in anthocyanin biosynthesis pathway is regulated by MYB75, a R2R3 MYB transcription factor. Anthocyanins 206-217 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 109-151 25450360-2 2014 It is shown that the expression of genes encoding the key enzymes such as dihydroflavonol 4-reductase (DFR), UDP-Glc: flavonoid 3-O-glucosyltransferase (UF3GT), and leucoanthocyanidin dioxygenase (LDOX) in anthocyanin biosynthesis pathway is regulated by MYB75, a R2R3 MYB transcription factor. Anthocyanins 206-217 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 153-158 25450360-4 2014 The photoreceptors cryptochrome 1 (CRY1), phytochrome B (phyB), and phytochrome A (phyA) are also shown to mediate light promotion of anthocyanin accumulation, respectively, whereas their downstream factor COP1, a master negative regulator of photomorphogensis, represses anthocyanin accumulation. Anthocyanins 134-145 cryptochrome 1 Arabidopsis thaliana 19-33 25450360-4 2014 The photoreceptors cryptochrome 1 (CRY1), phytochrome B (phyB), and phytochrome A (phyA) are also shown to mediate light promotion of anthocyanin accumulation, respectively, whereas their downstream factor COP1, a master negative regulator of photomorphogensis, represses anthocyanin accumulation. Anthocyanins 134-145 cryptochrome 1 Arabidopsis thaliana 35-39 25450360-4 2014 The photoreceptors cryptochrome 1 (CRY1), phytochrome B (phyB), and phytochrome A (phyA) are also shown to mediate light promotion of anthocyanin accumulation, respectively, whereas their downstream factor COP1, a master negative regulator of photomorphogensis, represses anthocyanin accumulation. Anthocyanins 134-145 phytochrome B Arabidopsis thaliana 42-55 25450360-4 2014 The photoreceptors cryptochrome 1 (CRY1), phytochrome B (phyB), and phytochrome A (phyA) are also shown to mediate light promotion of anthocyanin accumulation, respectively, whereas their downstream factor COP1, a master negative regulator of photomorphogensis, represses anthocyanin accumulation. Anthocyanins 134-145 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 206-210 25450360-4 2014 The photoreceptors cryptochrome 1 (CRY1), phytochrome B (phyB), and phytochrome A (phyA) are also shown to mediate light promotion of anthocyanin accumulation, respectively, whereas their downstream factor COP1, a master negative regulator of photomorphogensis, represses anthocyanin accumulation. Anthocyanins 272-283 cryptochrome 1 Arabidopsis thaliana 19-33 25450360-4 2014 The photoreceptors cryptochrome 1 (CRY1), phytochrome B (phyB), and phytochrome A (phyA) are also shown to mediate light promotion of anthocyanin accumulation, respectively, whereas their downstream factor COP1, a master negative regulator of photomorphogensis, represses anthocyanin accumulation. Anthocyanins 272-283 cryptochrome 1 Arabidopsis thaliana 35-39 25450360-4 2014 The photoreceptors cryptochrome 1 (CRY1), phytochrome B (phyB), and phytochrome A (phyA) are also shown to mediate light promotion of anthocyanin accumulation, respectively, whereas their downstream factor COP1, a master negative regulator of photomorphogensis, represses anthocyanin accumulation. Anthocyanins 272-283 phytochrome B Arabidopsis thaliana 42-55 25450360-4 2014 The photoreceptors cryptochrome 1 (CRY1), phytochrome B (phyB), and phytochrome A (phyA) are also shown to mediate light promotion of anthocyanin accumulation, respectively, whereas their downstream factor COP1, a master negative regulator of photomorphogensis, represses anthocyanin accumulation. Anthocyanins 272-283 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 206-210 25450360-8 2014 The dominant mutant of MYB75, pap1-D, accumulates significantly higher levels of anthocyanin than wild type under far-red light, whereas knockdown of MYBs (MYB75, MYB90, MYB113, and MYB114) through RNAi significantly reduces MeJA promotion of anthocyanin accumulation. Anthocyanins 81-92 production of anthocyanin pigment 1 Arabidopsis thaliana 23-28 25450360-8 2014 The dominant mutant of MYB75, pap1-D, accumulates significantly higher levels of anthocyanin than wild type under far-red light, whereas knockdown of MYBs (MYB75, MYB90, MYB113, and MYB114) through RNAi significantly reduces MeJA promotion of anthocyanin accumulation. Anthocyanins 81-92 phosphatidic acid phosphatase 1 Arabidopsis thaliana 30-34 25450360-8 2014 The dominant mutant of MYB75, pap1-D, accumulates significantly higher levels of anthocyanin than wild type under far-red light, whereas knockdown of MYBs (MYB75, MYB90, MYB113, and MYB114) through RNAi significantly reduces MeJA promotion of anthocyanin accumulation. Anthocyanins 243-254 production of anthocyanin pigment 1 Arabidopsis thaliana 23-28 25450360-11 2014 Upon MeJA application, the cop1-4 pap1-D double mutant accumulates considerably higher levels of anthocyanin than cop1-4 in darkness. Anthocyanins 97-108 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 27-31 25450360-11 2014 Upon MeJA application, the cop1-4 pap1-D double mutant accumulates considerably higher levels of anthocyanin than cop1-4 in darkness. Anthocyanins 97-108 phosphatidic acid phosphatase 1 Arabidopsis thaliana 34-38 25450360-14 2014 Our findings suggest that JA promotion of anthocyanin accumulation under far-red light is dependent on phyA signaling pathway, consisting of phyA, COP1, and MYB75. Anthocyanins 42-53 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 147-151 25450360-14 2014 Our findings suggest that JA promotion of anthocyanin accumulation under far-red light is dependent on phyA signaling pathway, consisting of phyA, COP1, and MYB75. Anthocyanins 42-53 production of anthocyanin pigment 1 Arabidopsis thaliana 157-162 25369033-4 2014 Although the MYB encoded by R was expressed at only very low levels in older seed coats of the black revertant RM30-R* line, it upregulated expression of anthocyanidin synthase genes (ANS2, ANS3) to promote the synthesis of anthocyanins. Anthocyanins 224-236 transcription factor MYB1 Glycine max 13-16 25369033-8 2014 The stabilized and more methylated RM30-R* revertant line apparently lacks effective binding of a transposae to its subterminal repeats, thus allowing intron splicing to proceed resulting in sufficient MYB protein to stimulate anthocyanin production and thus black seed coats. Anthocyanins 227-238 transcription factor MYB1 Glycine max 202-205 24749765-7 2014 In Annexin V analysis, anthocyanin protected HLE-B3 cells from apoptosis. Anthocyanins 23-34 annexin A5 Homo sapiens 3-12 24749765-9 2014 On the other hand, Bcl2 was increased from anthocyanin-treated lens cells. Anthocyanins 43-54 BCL2 apoptosis regulator Homo sapiens 19-23 24903357-5 2014 For example, the anthocyanin patterns of seedlings grown at pH 3.3 or in media lacking phosphate are very similar and characterized by relatively high levels of the anthocyanins A8 and A11. Anthocyanins 17-28 Chalcone-flavanone isomerase family protein Arabidopsis thaliana 185-188 25074586-1 2014 MAIN CONCLUSION: Our studies showed that an apple B-box protein, MdCOL11, the homolog of AtBBX22, is involved in UV-B- and temperature-induced anthocyanin biosynthesis in apple peel. Anthocyanins 143-154 light-regulated zinc finger protein 1 Arabidopsis thaliana 89-96 25074586-2 2014 Anthocyanin is responsible for the red pigmentation in apple peel and a R2R3 MYB gene, MdMYBA/1/10, a homolog of MdMYBA, controls its accumulation. Anthocyanins 0-11 transcription factor MYB113-like Malus domestica 113-119 25159050-0 2014 High AN1 variability and interaction with basic helix-loop-helix co-factors related to anthocyanin biosynthesis in potato leaves. Anthocyanins 87-98 transcription factor R2R3-MYB Solanum tuberosum 5-8 25159050-1 2014 AN1 is a regulatory gene that promotes anthocyanin biosynthesis in potato tubers and encodes a R2R3 MYB transcription factor. Anthocyanins 39-50 transcription factor R2R3-MYB Solanum tuberosum 0-3 25159050-3 2014 In our study we found that AN1 displays intraspecific sequence variability in both coding/non-coding regions and in the promoter, and that its expression is associated with high anthocyanin content in leaves of commercial potatoes. Anthocyanins 178-189 transcription factor R2R3-MYB Solanum tuberosum 27-30 25159050-4 2014 Expression analysis provided evidence that leaf pigmentation is associated to AN1 expression and that StJAF13 acts as putative AN1 co-regulator for anthocyanin gene expression in leaves of the red leaf variety "Magenta Love," while a concomitant expression of StbHLH1 may contribute to anthocyanin accumulation in leaves of "Double Fun." Anthocyanins 148-159 transcription factor GLABRA 3-like Solanum tuberosum 102-109 25159050-4 2014 Expression analysis provided evidence that leaf pigmentation is associated to AN1 expression and that StJAF13 acts as putative AN1 co-regulator for anthocyanin gene expression in leaves of the red leaf variety "Magenta Love," while a concomitant expression of StbHLH1 may contribute to anthocyanin accumulation in leaves of "Double Fun." Anthocyanins 148-159 transcription factor R2R3-MYB Solanum tuberosum 127-130 25159050-4 2014 Expression analysis provided evidence that leaf pigmentation is associated to AN1 expression and that StJAF13 acts as putative AN1 co-regulator for anthocyanin gene expression in leaves of the red leaf variety "Magenta Love," while a concomitant expression of StbHLH1 may contribute to anthocyanin accumulation in leaves of "Double Fun." Anthocyanins 286-297 transcription factor GLABRA 3-like Solanum tuberosum 102-109 25159050-8 2014 Our findings demonstrate that the classical loci identified for potato leaf anthocyanin accumulation correspond to AN1 and may represent an important step to expand our knowledge on the molecular mechanisms underlying anthocyanin biosynthesis in different plant tissues. Anthocyanins 76-87 transcription factor R2R3-MYB Solanum tuberosum 115-118 25159050-8 2014 Our findings demonstrate that the classical loci identified for potato leaf anthocyanin accumulation correspond to AN1 and may represent an important step to expand our knowledge on the molecular mechanisms underlying anthocyanin biosynthesis in different plant tissues. Anthocyanins 218-229 transcription factor R2R3-MYB Solanum tuberosum 115-118 25227758-6 2014 In this paper, AnthOMT, an O-methyltransferase (OMT) mediating the methylation of anthocyanins, has been identified and functionally characterized using a combined metabolomics and transcriptomics approach. Anthocyanins 82-94 flavonoid 3',5'-methyltransferase Solanum lycopersicum 15-22 25227758-11 2014 AnthOMT showed a strong affinity for glycosylated anthocyanins, while other flavonoid glycosides and aglycones were much less preferred. Anthocyanins 50-62 flavonoid 3',5'-methyltransferase Solanum lycopersicum 0-7 25227758-12 2014 Gene silencing experiments with AnthOMT resulted in reduced levels of the predominant methylated anthocyanins. Anthocyanins 97-109 flavonoid 3',5'-methyltransferase Solanum lycopersicum 32-39 25231967-7 2014 Concomitantly, two key biosynthetic genes (FLS1 and UFGT) were up-regulated by UV-B, leading to increased flavonol and anthocyanin skin concentration. Anthocyanins 119-130 flavonol synthase/flavanone 3-hydroxylase Vitis vinifera 43-47 25077916-0 2014 Plant food anthocyanins inhibit platelet granule secretion in hypercholesterolaemia: Involving the signalling pathway of PI3K-Akt. Anthocyanins 11-23 AKT serine/threonine kinase 1 Homo sapiens 126-129 25077916-5 2014 Anthocyanins consumption significantly reduced plasma levels of beta-thromboglobulin (beta-TG), soluble P-selectin, and of Regulated on Activation Normal T cell Expressed and Secreted (RANTES) as compared with the placebo. Anthocyanins 0-12 pro-platelet basic protein Homo sapiens 64-84 25077916-5 2014 Anthocyanins consumption significantly reduced plasma levels of beta-thromboglobulin (beta-TG), soluble P-selectin, and of Regulated on Activation Normal T cell Expressed and Secreted (RANTES) as compared with the placebo. Anthocyanins 0-12 pro-platelet basic protein Homo sapiens 86-93 25077916-5 2014 Anthocyanins consumption significantly reduced plasma levels of beta-thromboglobulin (beta-TG), soluble P-selectin, and of Regulated on Activation Normal T cell Expressed and Secreted (RANTES) as compared with the placebo. Anthocyanins 0-12 selectin P Homo sapiens 104-114 25077916-5 2014 Anthocyanins consumption significantly reduced plasma levels of beta-thromboglobulin (beta-TG), soluble P-selectin, and of Regulated on Activation Normal T cell Expressed and Secreted (RANTES) as compared with the placebo. Anthocyanins 0-12 C-C motif chemokine ligand 5 Homo sapiens 185-191 25077916-8 2014 Further, anthocyanins inhibited platelet PI3K/Akt activation and consequently attenuated eNOS phosphorylation and cGMP production, thus interrupting MAPK activation. Anthocyanins 9-21 AKT serine/threonine kinase 1 Homo sapiens 46-49 25077916-9 2014 LY294002, a PI3K inhibitor, did not cause additional inhibitory efficacy, indicating that anthocyanin-induced effects may be involved in inhibition of the PI3K/Akt signalling pathway. Anthocyanins 90-101 AKT serine/threonine kinase 1 Homo sapiens 160-163 25532839-4 2014 C-18-based cartridges presented a very low retention for the glucosylated anthocyanidins while vinylbenzene-based cartridges showed excellent retention for these compounds. Anthocyanins 74-88 Bardet-Biedl syndrome 9 Homo sapiens 0-4 25521508-6 2014 Our results indicate that STK exerts its effect by direct regulation of the gene encoding BANYULS/ANTHOCYANIDIN REDUCTASE (BAN/ANR), which converts anthocyanidins into their corresponding 2,3-cis-flavan-3-ols. Anthocyanins 148-162 K-box region and MADS-box transcription factor family protein Arabidopsis thaliana 26-29 25521508-6 2014 Our results indicate that STK exerts its effect by direct regulation of the gene encoding BANYULS/ANTHOCYANIDIN REDUCTASE (BAN/ANR), which converts anthocyanidins into their corresponding 2,3-cis-flavan-3-ols. Anthocyanins 148-162 NAD(P)-binding Rossmann-fold superfamily protein Arabidopsis thaliana 90-121 25342745-2 2014 WDR68 affects multiple and diverse physiological functions, such as controlling anthocyanin synthesis in plants, tissue growth in insects, and craniofacial development in vertebrates. Anthocyanins 80-91 DDB1 and CUL4 associated factor 7 Homo sapiens 0-5 25477896-3 2014 Anthocyanin concentrations were significantly increased by over-expression or decreased by knock-down of the R2R3 MYB activator, MYB10. Anthocyanins 0-11 transcription factor MYB12-like Fragaria vesca 114-117 25108127-2 2014 Dihydroflavonol 4-reductase (DFR) is part of an important step in the flavonoid biosynthetic pathway of anthocyanins. Anthocyanins 104-116 dihydroflavonol 4-reductase Brassica rapa 29-32 25108127-3 2014 This study characterized 12 DFR genes of Brassica rapa and investigated their association with anthocyanin coloration, as well as cold and freezing stress in several genotypes of B. rapa. Anthocyanins 95-106 dihydroflavonol 4-reductase Brassica rapa 28-31 24467527-8 2014 Thus, we conclude that the elevated anthocyanin accumulation in thf1 is attributed to an increase in JA levels. Anthocyanins 36-47 photosystem II reaction center PSB29 protein Arabidopsis thaliana 64-68 26461383-8 2014 Our screening experiments lead to a formulation containing a mix of different anthocyanins (MAF) with antioxidant and neuroprotective effect at very low doses. Anthocyanins 78-90 MAF bZIP transcription factor Homo sapiens 92-95 25070704-0 2014 Anthocyanins potentiate the activity of trastuzumab in human epidermal growth factor receptor 2-positive breast cancer cells in vitro and in vivo. Anthocyanins 0-12 erb-b2 receptor tyrosine kinase 2 Homo sapiens 61-95 25062774-3 2014 Cyanidin-3-glucoside (C3G), a member of the anthocyanin family, is present in various vegetables and fruits especially in edible berries, and displays potent antioxidant and anticarcinogenic properties. Anthocyanins 44-55 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 0-25 25895378-11 2014 CONCLUSION: The total anthocyanins accumulation in Notoginseng Radix et Rhizoma implies the content increases of the total saponins, notoginsenoside R1, ginsenoside Rd and ginsenoside Re, and the slight decreases of ginsenoside Rg1 and ginsenoside Rb1 contents; but the type and relative contents of saponin monomers remain unchanged. Anthocyanins 22-34 protein phosphatase 1 regulatory subunit 3A Homo sapiens 228-231 25895378-11 2014 CONCLUSION: The total anthocyanins accumulation in Notoginseng Radix et Rhizoma implies the content increases of the total saponins, notoginsenoside R1, ginsenoside Rd and ginsenoside Re, and the slight decreases of ginsenoside Rg1 and ginsenoside Rb1 contents; but the type and relative contents of saponin monomers remain unchanged. Anthocyanins 22-34 RB transcriptional corepressor 1 Homo sapiens 248-251 25352726-0 2014 Targeting cysteine rich C1 domain of Scaffold protein Kinase Suppressor of Ras (KSR) with anthocyanidins and flavonoids - a binding affinity characterization study. Anthocyanins 90-104 kinase suppressor of ras 1 Homo sapiens 54-78 25352726-0 2014 Targeting cysteine rich C1 domain of Scaffold protein Kinase Suppressor of Ras (KSR) with anthocyanidins and flavonoids - a binding affinity characterization study. Anthocyanins 90-104 kinase suppressor of ras 1 Homo sapiens 80-83 25352726-4 2014 In that perspective the cysteine rich C1 domain of scaffold proteins kinase suppressor of Ras-1 was targeted rather than its ATP binding site with small ligand molecules like flavones and anthocyanidins and analyzed through insilico docking studies. Anthocyanins 188-202 kinase suppressor of ras 1 Homo sapiens 69-93 25268129-4 2014 To understand the influence of herbivore attack on the metabolic engineering of flavonoids, we examined tobacco plants overexpressing the Arabidopsis PAP1 gene (encoding an MYB transcription factor), which accumulated anthocyanin pigments and other flavonoids/phenylpropanoids. Anthocyanins 218-229 phosphatidic acid phosphatase 1 Arabidopsis thaliana 150-154 25268379-0 2014 Arabidopsis CAPRICE (MYB) and GLABRA3 (bHLH) control tomato (Solanum lycopersicum) anthocyanin biosynthesis. Anthocyanins 83-94 Homeodomain-like superfamily protein Arabidopsis thaliana 12-19 25268379-0 2014 Arabidopsis CAPRICE (MYB) and GLABRA3 (bHLH) control tomato (Solanum lycopersicum) anthocyanin biosynthesis. Anthocyanins 83-94 R2R3MYB transcription factor 14 Solanum lycopersicum 21-24 25268379-0 2014 Arabidopsis CAPRICE (MYB) and GLABRA3 (bHLH) control tomato (Solanum lycopersicum) anthocyanin biosynthesis. Anthocyanins 83-94 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 30-37 25268379-3 2014 CPC and GL3 are also known to be involved in anthocyanin biosynthesis. Anthocyanins 45-56 Homeodomain-like superfamily protein Arabidopsis thaliana 0-3 25268379-3 2014 CPC and GL3 are also known to be involved in anthocyanin biosynthesis. Anthocyanins 45-56 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 8-11 25268379-4 2014 After transformation into tomato, 35S::CPC inhibited anthocyanin accumulation, whereas GL3::GL3 enhanced anthocyanin accumulation. Anthocyanins 53-64 Homeodomain-like superfamily protein Arabidopsis thaliana 39-42 25268379-4 2014 After transformation into tomato, 35S::CPC inhibited anthocyanin accumulation, whereas GL3::GL3 enhanced anthocyanin accumulation. Anthocyanins 105-116 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 87-90 25268379-4 2014 After transformation into tomato, 35S::CPC inhibited anthocyanin accumulation, whereas GL3::GL3 enhanced anthocyanin accumulation. Anthocyanins 105-116 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 92-95 25268379-5 2014 Real-time reverse transcription PCR analyses showed that the expression of anthocyanin biosynthetic genes including Phe-ammonia lyase (PAL), the flavonoid pathway genes chalcone synthase (CHS), dihydroflavonol reductase (DFR), and anthocyanidin synthase (ANS) were repressed in 35S::CPC tomato. Anthocyanins 75-86 phenylalanine ammonia-lyase Solanum lycopersicum 116-133 25268379-5 2014 Real-time reverse transcription PCR analyses showed that the expression of anthocyanin biosynthetic genes including Phe-ammonia lyase (PAL), the flavonoid pathway genes chalcone synthase (CHS), dihydroflavonol reductase (DFR), and anthocyanidin synthase (ANS) were repressed in 35S::CPC tomato. Anthocyanins 75-86 phenylalanine ammonia-lyase Solanum lycopersicum 135-138 25268379-5 2014 Real-time reverse transcription PCR analyses showed that the expression of anthocyanin biosynthetic genes including Phe-ammonia lyase (PAL), the flavonoid pathway genes chalcone synthase (CHS), dihydroflavonol reductase (DFR), and anthocyanidin synthase (ANS) were repressed in 35S::CPC tomato. Anthocyanins 75-86 dihydroflavonol 4-reductase Solanum lycopersicum 194-219 25268379-5 2014 Real-time reverse transcription PCR analyses showed that the expression of anthocyanin biosynthetic genes including Phe-ammonia lyase (PAL), the flavonoid pathway genes chalcone synthase (CHS), dihydroflavonol reductase (DFR), and anthocyanidin synthase (ANS) were repressed in 35S::CPC tomato. Anthocyanins 75-86 dihydroflavonol 4-reductase Solanum lycopersicum 221-224 25268379-5 2014 Real-time reverse transcription PCR analyses showed that the expression of anthocyanin biosynthetic genes including Phe-ammonia lyase (PAL), the flavonoid pathway genes chalcone synthase (CHS), dihydroflavonol reductase (DFR), and anthocyanidin synthase (ANS) were repressed in 35S::CPC tomato. Anthocyanins 75-86 Homeodomain-like superfamily protein Arabidopsis thaliana 283-286 25237750-4 2014 The aim of this study was to evaluate the effect of anthocyanins and proanthocyanidins contained in this extract on the activity and expression of intestinal and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT). Anthocyanins 52-64 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 197-220 25237750-4 2014 The aim of this study was to evaluate the effect of anthocyanins and proanthocyanidins contained in this extract on the activity and expression of intestinal and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT). Anthocyanins 52-64 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 222-228 25237750-4 2014 The aim of this study was to evaluate the effect of anthocyanins and proanthocyanidins contained in this extract on the activity and expression of intestinal and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT). Anthocyanins 52-64 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 240-245 25237750-4 2014 The aim of this study was to evaluate the effect of anthocyanins and proanthocyanidins contained in this extract on the activity and expression of intestinal and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT). Anthocyanins 52-64 carbonyl reductase 1 Rattus norvegicus 248-268 25237750-4 2014 The aim of this study was to evaluate the effect of anthocyanins and proanthocyanidins contained in this extract on the activity and expression of intestinal and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT). Anthocyanins 52-64 carbonyl reductase 1 Rattus norvegicus 270-274 25237750-4 2014 The aim of this study was to evaluate the effect of anthocyanins and proanthocyanidins contained in this extract on the activity and expression of intestinal and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT). Anthocyanins 52-64 hematopoietic prostaglandin D synthase Rattus norvegicus 277-302 25237750-4 2014 The aim of this study was to evaluate the effect of anthocyanins and proanthocyanidins contained in this extract on the activity and expression of intestinal and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT). Anthocyanins 52-64 hematopoietic prostaglandin D synthase Rattus norvegicus 304-307 25237750-4 2014 The aim of this study was to evaluate the effect of anthocyanins and proanthocyanidins contained in this extract on the activity and expression of intestinal and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT). Anthocyanins 52-64 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 313-341 25237750-4 2014 The aim of this study was to evaluate the effect of anthocyanins and proanthocyanidins contained in this extract on the activity and expression of intestinal and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT). Anthocyanins 52-64 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 343-346 25075866-7 2014 Only the anthocyanin-rich fraction reduced the activation of NF-kappaB, induced by IL-1beta in intestinal epithelial Caco-2 cells. Anthocyanins 9-20 nuclear factor kappa B subunit 1 Homo sapiens 61-70 25075866-7 2014 Only the anthocyanin-rich fraction reduced the activation of NF-kappaB, induced by IL-1beta in intestinal epithelial Caco-2 cells. Anthocyanins 9-20 interleukin 1 beta Homo sapiens 83-91 25116725-8 2014 An increasing of both the flavanones and anthocyanins concentration was observed in the NF retentate by increasing the volume reduction factor (VRF). Anthocyanins 41-53 vascular endothelial growth factor B Homo sapiens 144-147 24948678-12 2014 The accumulation of anthocyanin in petals was reduced and the same underlying mechanism of R2R3 MYB NtAN2 transcript reduction was demonstrated. Anthocyanins 20-31 transcription factor MYB114-like Nicotiana tabacum 100-105 24467527-0 2014 THF1 mutations lead to increased basal and wound-induced levels of oxylipins that stimulate anthocyanin biosynthesis via COI1 signaling in Arabidopsis. Anthocyanins 92-103 photosystem II reaction center PSB29 protein Arabidopsis thaliana 0-4 24467527-0 2014 THF1 mutations lead to increased basal and wound-induced levels of oxylipins that stimulate anthocyanin biosynthesis via COI1 signaling in Arabidopsis. Anthocyanins 92-103 RNI-like superfamily protein Arabidopsis thaliana 121-125 24467527-3 2014 Here, we investigated the mechanism by which the deletion of thylakoid formation1 (THF1) leads to an increased level of anthocyanin in Arabidopsis thaliana L. Physiological and genetic evidence showed that the increased level of anthocyanin in thf1 is dependent on coronatine-insensitive1 (COI1) signaling. Anthocyanins 120-131 photosystem II reaction center PSB29 protein Arabidopsis thaliana 83-87 24467527-3 2014 Here, we investigated the mechanism by which the deletion of thylakoid formation1 (THF1) leads to an increased level of anthocyanin in Arabidopsis thaliana L. Physiological and genetic evidence showed that the increased level of anthocyanin in thf1 is dependent on coronatine-insensitive1 (COI1) signaling. Anthocyanins 229-240 photosystem II reaction center PSB29 protein Arabidopsis thaliana 83-87 24467527-3 2014 Here, we investigated the mechanism by which the deletion of thylakoid formation1 (THF1) leads to an increased level of anthocyanin in Arabidopsis thaliana L. Physiological and genetic evidence showed that the increased level of anthocyanin in thf1 is dependent on coronatine-insensitive1 (COI1) signaling. Anthocyanins 229-240 photosystem II reaction center PSB29 protein Arabidopsis thaliana 244-248 24467527-3 2014 Here, we investigated the mechanism by which the deletion of thylakoid formation1 (THF1) leads to an increased level of anthocyanin in Arabidopsis thaliana L. Physiological and genetic evidence showed that the increased level of anthocyanin in thf1 is dependent on coronatine-insensitive1 (COI1) signaling. Anthocyanins 229-240 RNI-like superfamily protein Arabidopsis thaliana 265-288 24467527-3 2014 Here, we investigated the mechanism by which the deletion of thylakoid formation1 (THF1) leads to an increased level of anthocyanin in Arabidopsis thaliana L. Physiological and genetic evidence showed that the increased level of anthocyanin in thf1 is dependent on coronatine-insensitive1 (COI1) signaling. Anthocyanins 229-240 RNI-like superfamily protein Arabidopsis thaliana 290-294 24446317-3 2014 RESULTS: Seven anthocyanin monomers were successfully isolated with an Xbridge Prep C18 column on a preparative scale. Anthocyanins 15-26 Bardet-Biedl syndrome 9 Homo sapiens 84-87 24821109-2 2014 Cyanidin-3-O-beta-glucoside (C3G), a classic anthocyanin, has been reported to reduce oxidative stress and attenuate non-alcoholic steatohepatitis in mice. Anthocyanins 45-56 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 0-27 24880552-1 2014 Anthocyanidin reductase (ANR) is an NADPH-/NADH-dependent enzyme that transfers two hydrides to anthocyanidins to produce three types of isomeric flavan-3-ols. Anthocyanins 96-110 anthocyanidin reductase ((2S)-flavan-3-ol-forming) Vitis vinifera 25-28 24821109-2 2014 Cyanidin-3-O-beta-glucoside (C3G), a classic anthocyanin, has been reported to reduce oxidative stress and attenuate non-alcoholic steatohepatitis in mice. Anthocyanins 45-56 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 29-32 23883519-0 2014 Kenyan purple tea anthocyanins ability to cross the blood brain barrier and reinforce brain antioxidant capacity in mice. Anthocyanins 18-30 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 14-17 24995924-0 2014 Antioxidant activity and acetylcholinesterase inhibition of grape skin anthocyanin (GSA). Anthocyanins 71-82 acetylcholinesterase Mus musculus 25-45 24995924-1 2014 We aimed to investigate the antioxidant and acetylcholinesterase inhibitory activities of the anthocyanin rich extract of grape skin. Anthocyanins 94-105 acetylcholinesterase Mus musculus 44-64 24302118-0 2014 Properties and stability of blueberry anthocyanin--bovine serum albumin nanoparticles. Anthocyanins 38-49 albumin Homo sapiens 58-71 24302118-3 2014 In this study, the characteristics of nanoparticles, formed by the interactions of anthocyanins with bovine serum albumin (BSA), and their impact on the oxidation stability of anthocyanins were investigated. Anthocyanins 83-95 albumin Homo sapiens 108-121 23883519-4 2014 This study investigated the ability of Kenyan purple tea ACNs to cross the BBB and boost the brain antioxidant capacity. Anthocyanins 57-61 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 53-56 24845816-0 2014 Substituent effects on the binding of natural product anthocyanidin inhibitors to influenza neuraminidase with mass spectrometry. Anthocyanins 54-67 neuraminidase 1 Homo sapiens 92-105 24682657-6 2014 Anthocyanins markedly reduced gene and protein expression levels of lipogenic transcription factors such as liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferators-activated receptor-gamma, and CCAAT enhancer-binding protein-alpha. Anthocyanins 0-12 nuclear receptor subfamily 1, group H, member 3 Mus musculus 108-130 24682657-6 2014 Anthocyanins markedly reduced gene and protein expression levels of lipogenic transcription factors such as liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferators-activated receptor-gamma, and CCAAT enhancer-binding protein-alpha. Anthocyanins 0-12 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 233-269 24682657-7 2014 In addition, the target gene and protein expression of these lipogenic transcription factors such as fatty acid synthase, stearoyl-CoA desaturase-1, and acetyl-CoA carboxylase alpha were markedly suppressed by anthocyanins. Anthocyanins 210-222 stearoyl-Coenzyme A desaturase 1 Mus musculus 122-147 24929515-7 2014 Immunocytochemistry analysis showed that the expression of caspase-9 and cytochrome c were obviously increased after the anthocyanins treatment. Anthocyanins 121-133 caspase 9 Homo sapiens 59-68 24929515-7 2014 Immunocytochemistry analysis showed that the expression of caspase-9 and cytochrome c were obviously increased after the anthocyanins treatment. Anthocyanins 121-133 cytochrome c, somatic Homo sapiens 73-85 24929515-9 2014 Methylation-specific PCR (MSP) showed that the amount of unmethylated p53 increased, indicating that the anthocyanins can down-regulate the methylation of p53. Anthocyanins 105-117 tumor protein p53 Homo sapiens 70-73 24929515-9 2014 Methylation-specific PCR (MSP) showed that the amount of unmethylated p53 increased, indicating that the anthocyanins can down-regulate the methylation of p53. Anthocyanins 105-117 tumor protein p53 Homo sapiens 155-158 24845816-1 2014 The binding of three closely related anthocyanins within the 430-cavity of influenza neuraminidase is studied using a combination of mass spectrometry and molecular docking. Anthocyanins 37-49 neuraminidase 1 Homo sapiens 85-98 24577454-3 2014 We also examined the in vitro inhibitory activity of potato anthocyanin extracts on rat intestinal alpha-glucosidase. Anthocyanins 60-71 neutral alpha-glucosidase AB-like Solanum tuberosum 99-116 24577454-12 2014 The GI of coloured potatoes is significantly related to their polyphenol content, possibly mediated through an inhibitory effect of anthocyanins on intestinal alpha-glucosidase. Anthocyanins 132-144 neutral alpha-glucosidase AB-like Solanum tuberosum 159-176 24585214-0 2014 The inhibitory effect of anthocyanins on Akt on invasion and epithelial-mesenchymal transition is not associated with the anti-EGFR effect of the anthocyanins. Anthocyanins 25-37 AKT serine/threonine kinase 1 Homo sapiens 41-44 24585214-1 2014 Evidence suggests that anthocyanins inhibit EGFR and Akt activity. Anthocyanins 23-35 epidermal growth factor receptor Homo sapiens 44-48 24585214-1 2014 Evidence suggests that anthocyanins inhibit EGFR and Akt activity. Anthocyanins 23-35 AKT serine/threonine kinase 1 Homo sapiens 53-56 24585214-2 2014 However, it is still unknown whether the inhibitory effect of anthocyanins on Akt is associated with the anti-EGFR effect. Anthocyanins 62-74 AKT serine/threonine kinase 1 Homo sapiens 78-81 24585214-2 2014 However, it is still unknown whether the inhibitory effect of anthocyanins on Akt is associated with the anti-EGFR effect. Anthocyanins 62-74 epidermal growth factor receptor Homo sapiens 110-114 24595303-0 2014 Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Anthocyanins 0-11 adiponectin, C1Q and collagen domain containing Mus musculus 22-33 24619996-3 2014 Overexpression of MYB75 (oxMYB75) in Arabidopsis results in increasing anthocyanin and flavonol levels which enhances plant resistance to generalist caterpillars. Anthocyanins 71-82 production of anthocyanin pigment 1 Arabidopsis thaliana 18-23 24595303-2 2014 In this study, we evaluated a potential role for adiponectin in the protective effects of anthocyanin on diabetes-related endothelial dysfunction. Anthocyanins 90-101 adiponectin, C1Q and collagen domain containing Mus musculus 49-60 24595303-11 2014 Furthermore, purified anthocyanin supplementation significantly improved flow-mediated dilation (FMD) and increased serum adiponectin concentrations in patients with type 2 diabetes. Anthocyanins 22-33 adiponectin, C1Q and collagen domain containing Homo sapiens 122-133 24595303-12 2014 Changes in adiponectin concentrations positively correlated with FMD in the anthocyanin group. Anthocyanins 76-87 adiponectin, C1Q and collagen domain containing Mus musculus 11-22 24374256-0 2014 Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats. Anthocyanins 26-38 acetylcholinesterase Rattus norvegicus 42-62 24393263-0 2014 Anthocyanins protect against kainic acid-induced excitotoxicity and apoptosis via ROS-activated AMPK pathway in hippocampal neurons. Anthocyanins 0-12 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 96-100 24393263-8 2014 Anthocyanins attenuated KA-induced dysregulation of Ca(2+), ROS accumulation, activation of AMPK, and increase in percentage of apoptotic cells. Anthocyanins 0-12 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 92-96 24304603-0 2014 Cloning and characterization of a potato StAN11 gene involved in anthocyanin biosynthesis regulation. Anthocyanins 65-76 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 41-47 24304603-5 2014 In order to verify its role in anthocyanin biosynthesis, StAN11 was inserted behind the CaMV-35S promoter of pCMBIA1304 and the recombination vector was introduced into the potato cultivar Desiree plants by Agrobacterium-mediated transformation. Anthocyanins 31-42 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 57-63 24304603-8 2014 This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. Anthocyanins 44-55 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 27-33 24304603-8 2014 This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. Anthocyanins 44-55 dihydroflavonol-4-reductase Solanum tuberosum 94-97 24304603-8 2014 This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. Anthocyanins 44-55 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 186-192 24304603-8 2014 This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. Anthocyanins 129-140 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 27-33 24304603-8 2014 This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. Anthocyanins 129-140 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 186-192 24304603-8 2014 This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. Anthocyanins 129-140 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 27-33 24565673-0 2014 Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-kappaB independent of NRF2-mediated mechanism. Anthocyanins 6-18 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 140-149 24304603-8 2014 This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. Anthocyanins 129-140 protein TRANSPARENT TESTA GLABRA 1-like Solanum tuberosum 186-192 24565673-0 2014 Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-kappaB independent of NRF2-mediated mechanism. Anthocyanins 6-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 165-169 24565673-5 2014 Interleukin 1beta (IL-1beta) messenger RNA (mRNA) levels were significantly decreased by all berry anthocyanins at 10 mug/ml or higher. Anthocyanins 99-111 interleukin 1 beta Mus musculus 0-17 24565673-5 2014 Interleukin 1beta (IL-1beta) messenger RNA (mRNA) levels were significantly decreased by all berry anthocyanins at 10 mug/ml or higher. Anthocyanins 99-111 interleukin 1 beta Mus musculus 19-27 24565673-8 2014 LPS-induced nuclear factor kappaB (NF-kappaB) p65 translocation to the nucleus was markedly attenuated by all of the berry anthocyanins. Anthocyanins 123-135 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 35-44 24565673-8 2014 LPS-induced nuclear factor kappaB (NF-kappaB) p65 translocation to the nucleus was markedly attenuated by all of the berry anthocyanins. Anthocyanins 123-135 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 24565673-10 2014 However, in the BMM from Nrf2(-/-) mice, the anthocyanin fractions were able to significantly decrease IL-1beta mRNA despite the fact that ROS levels were not significantly affected. Anthocyanins 45-56 nuclear factor, erythroid derived 2, like 2 Mus musculus 25-29 24565673-10 2014 However, in the BMM from Nrf2(-/-) mice, the anthocyanin fractions were able to significantly decrease IL-1beta mRNA despite the fact that ROS levels were not significantly affected. Anthocyanins 45-56 interleukin 1 beta Mus musculus 103-111 24440762-8 2014 The mice group that was treated with coenzyme-Q10 or purple tea anthocyanins had higher levels of GSH and aconitase-1 in the brain compared to untreated groups, implying a boost in brain antioxidant capacity. Anthocyanins 64-76 aconitase 1 Mus musculus 106-117 24370633-9 2014 The resulting data showed that 2,4-D, NAA and IAA control anthocyanin biosynthesis by regulating the expression of TT8, GL3 and PAP1 as well as genes in the anthocyanin biosynthetic pathway, such as DFR and ANS. Anthocyanins 58-69 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 115-118 24370633-9 2014 The resulting data showed that 2,4-D, NAA and IAA control anthocyanin biosynthesis by regulating the expression of TT8, GL3 and PAP1 as well as genes in the anthocyanin biosynthetic pathway, such as DFR and ANS. Anthocyanins 58-69 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 120-123 24117455-5 2014 The analysis of hypocotyl growth inhibition and anthocyanin accumulation responses in BnCRY1 overexpressors substantiates that regulation of seedling photomorphogenesis by cry1 is dependent on light intensity. Anthocyanins 48-59 cryptochrome-1-like Brassica napus 86-92 24370633-9 2014 The resulting data showed that 2,4-D, NAA and IAA control anthocyanin biosynthesis by regulating the expression of TT8, GL3 and PAP1 as well as genes in the anthocyanin biosynthetic pathway, such as DFR and ANS. Anthocyanins 58-69 phosphatidic acid phosphatase 1 Arabidopsis thaliana 128-132 24117455-5 2014 The analysis of hypocotyl growth inhibition and anthocyanin accumulation responses in BnCRY1 overexpressors substantiates that regulation of seedling photomorphogenesis by cry1 is dependent on light intensity. Anthocyanins 48-59 cryptochrome-1-like Brassica napus 172-176 24370633-9 2014 The resulting data showed that 2,4-D, NAA and IAA control anthocyanin biosynthesis by regulating the expression of TT8, GL3 and PAP1 as well as genes in the anthocyanin biosynthetic pathway, such as DFR and ANS. Anthocyanins 58-69 dihydroflavonol 4-reductase Arabidopsis thaliana 199-202 24370633-0 2014 Regulation of anthocyanin biosynthesis in Arabidopsis thaliana red pap1-D cells metabolically programmed by auxins. Anthocyanins 14-25 phosphatidic acid phosphatase 1 Arabidopsis thaliana 67-71 24556963-0 2014 Arabidopsis AtPAP1 transcription factor induces anthocyanin production in transgenic Taraxacum brevicorniculatum. Anthocyanins 48-59 phosphatidic acid phosphatase 1 Arabidopsis thaliana 12-18 24370633-1 2014 Red pap1-D cells of Arabidopsis thaliana have been cloned from production of anthocyanin pigmentation 1-Dominant (pap1-D) plants. Anthocyanins 77-88 phosphatidic acid phosphatase 1 Arabidopsis thaliana 4-8 24370633-2 2014 The red cells are metabolically programmed to produce high levels of anthocyanins by a WD40-bHLH-MYB complex that is composed of the TTG1, TT8/GL3 and PAP1 transcription factors. Anthocyanins 69-81 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 133-137 24370633-2 2014 The red cells are metabolically programmed to produce high levels of anthocyanins by a WD40-bHLH-MYB complex that is composed of the TTG1, TT8/GL3 and PAP1 transcription factors. Anthocyanins 69-81 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 139-142 24370633-2 2014 The red cells are metabolically programmed to produce high levels of anthocyanins by a WD40-bHLH-MYB complex that is composed of the TTG1, TT8/GL3 and PAP1 transcription factors. Anthocyanins 69-81 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 143-146 24370633-2 2014 The red cells are metabolically programmed to produce high levels of anthocyanins by a WD40-bHLH-MYB complex that is composed of the TTG1, TT8/GL3 and PAP1 transcription factors. Anthocyanins 69-81 phosphatidic acid phosphatase 1 Arabidopsis thaliana 151-155 24576765-0 2014 Ferulic acid 5-hydroxylase 1 is essential for expression of anthocyanin biosynthesis-associated genes and anthocyanin accumulation under photooxidative stress in Arabidopsis. Anthocyanins 60-71 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 0-28 24556963-1 2014 KEY MESSAGE: This study developed a new purple coloured Taraxacum brevicorniculatum plant through genetic transformation using the Arabidopsis AtPAP1 gene, which overproduced anthocyanins in its vegetative tissues. Anthocyanins 175-187 phosphatidic acid phosphatase 1 Arabidopsis thaliana 143-149 24576765-0 2014 Ferulic acid 5-hydroxylase 1 is essential for expression of anthocyanin biosynthesis-associated genes and anthocyanin accumulation under photooxidative stress in Arabidopsis. Anthocyanins 106-117 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 0-28 24576765-2 2014 By comprehensive reverse genetic analysis of chloroplast-produced H2O2-responsive genes, we isolated here an anthocyanin-deficient mutant under photooxidative stress, which lacked ferulate 5-hydroxylase 1 (FAH1) involved in the phenylpropanoid pathway. Anthocyanins 109-120 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 180-204 24576765-2 2014 By comprehensive reverse genetic analysis of chloroplast-produced H2O2-responsive genes, we isolated here an anthocyanin-deficient mutant under photooxidative stress, which lacked ferulate 5-hydroxylase 1 (FAH1) involved in the phenylpropanoid pathway. Anthocyanins 109-120 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 206-210 24576765-4 2014 These findings suggest that FAH1 is essential for expression of anthocyanin biosynthesis-associated genes and anthocyanin accumulation under photooxidative stress in Arabidopsis. Anthocyanins 64-75 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 28-32 24556963-7 2014 The AtPAP1 expression levels were estimated by quantitative real-time PCR and were highly correlated with the levels of total anthocyanins in five independent transgenic lines. Anthocyanins 126-138 phosphatidic acid phosphatase 1 Arabidopsis thaliana 4-10 24666969-0 2014 The involvement of AMPK/GSK3-beta signals in the control of metastasis and proliferation in hepato-carcinoma cells treated with anthocyanins extracted from Korea wild berry Meoru. Anthocyanins 128-140 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 19-23 24666969-0 2014 The involvement of AMPK/GSK3-beta signals in the control of metastasis and proliferation in hepato-carcinoma cells treated with anthocyanins extracted from Korea wild berry Meoru. Anthocyanins 128-140 glycogen synthase kinase 3 beta Homo sapiens 24-33 24576765-4 2014 These findings suggest that FAH1 is essential for expression of anthocyanin biosynthesis-associated genes and anthocyanin accumulation under photooxidative stress in Arabidopsis. Anthocyanins 110-121 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 28-32 24576765-6 2014 Thus, it is likely that chloroplastic H2O2 activates FAH1 expression to induce anthocyanin accumulation for protecting cells from photooxidative stress. Anthocyanins 79-90 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 53-57 24363205-0 2014 Anthocyanidins, novel FAK inhibitors, attenuate PDGF-BB-induced aortic smooth muscle cell migration and neointima formation. Anthocyanins 0-14 protein tyrosine kinase 2 Rattus norvegicus 22-25 24363205-8 2014 Moreover, anthocyanidins that reduced HASMC migration also inhibited PDGF-BB-induced FAK phosphorylation, F-actin reduction, and FAK activity, and directly bound with FAK. Anthocyanins 10-24 protein tyrosine kinase 2 Rattus norvegicus 85-88 24363205-8 2014 Moreover, anthocyanidins that reduced HASMC migration also inhibited PDGF-BB-induced FAK phosphorylation, F-actin reduction, and FAK activity, and directly bound with FAK. Anthocyanins 10-24 protein tyrosine kinase 2 Rattus norvegicus 129-132 24363205-8 2014 Moreover, anthocyanidins that reduced HASMC migration also inhibited PDGF-BB-induced FAK phosphorylation, F-actin reduction, and FAK activity, and directly bound with FAK. Anthocyanins 10-24 protein tyrosine kinase 2 Rattus norvegicus 129-132 24363205-10 2014 CONCLUSION: The results of the present study demonstrate that anthocyanidins can directly bind with and suppress the activity of FAK with atherosclerosis-preventive effects. Anthocyanins 62-76 protein tyrosine kinase 2 Rattus norvegicus 129-132 24453228-9 2014 Phylogenetic analysis indicates that Peace is closely related to AtMYB123 (TT2), which regulates proanthocyanidin biosynthesis in Arabidopsis, and to anthocyanin regulators in monocots rather than to regulators in dicots. Anthocyanins 150-161 Duplicated homeodomain-like superfamily protein Arabidopsis thaliana 65-73 23723132-2 2014 The cyanidin-3-O-glucoside (C3G) is one of the principal types of anthocyanins. Anthocyanins 66-78 Rap guanine nucleotide exchange factor 1 Homo sapiens 28-31 24424324-5 2014 Expression of the wild-type SlCHI1 gene from its native promoter complemented the anthocyanin deficiency in af. Anthocyanins 82-93 chalcone--flavonone isomerase Solanum lycopersicum 28-34 25007586-1 2014 Anthocyanins are a ubiquitous group of water-soluble plant pigments of the flavonoid family, with anticancer property through HER-2 signaling pathway. Anthocyanins 0-12 erb-b2 receptor tyrosine kinase 2 Homo sapiens 126-131 25007586-3 2014 According to the crystal structure of HER-2 kinase domain and 12 main antitumor compounds of anthocyanins as well as ATP, a molecular docking study was performed by MVD program. Anthocyanins 93-105 erb-b2 receptor tyrosine kinase 2 Homo sapiens 38-43 25007586-4 2014 All 12 compounds could bind to the same cavity of HER-2 kinase domain by high affinity (MolDock Score < -105 kJ/mol for anthocyanidins, < -130 kJ/mol for anthocyanidins-glc), where hydrophobic force and hydrogen bond played key roles. Anthocyanins 123-137 erb-b2 receptor tyrosine kinase 2 Homo sapiens 50-55 25007586-5 2014 Additionally, this cavity overlapped with ATP binding (MolDock Score = -161 kJ/mol) domain; the binding of anthocyanins presumably interfered the H bond formation between ATP and HER-2. Anthocyanins 107-119 erb-b2 receptor tyrosine kinase 2 Homo sapiens 179-184 25007586-6 2014 These results indicate that anthocyanins may competitively bind to ATP binding site in HER-2 kinase domain by suppressing HER-2 activation and downstream signaling cascade. Anthocyanins 28-40 erb-b2 receptor tyrosine kinase 2 Homo sapiens 87-92 25007586-6 2014 These results indicate that anthocyanins may competitively bind to ATP binding site in HER-2 kinase domain by suppressing HER-2 activation and downstream signaling cascade. Anthocyanins 28-40 erb-b2 receptor tyrosine kinase 2 Homo sapiens 122-127 25007586-7 2014 This may provide useful theoretical instruction for the molecular mechanism of HER-2 kinase activity inhibition by anthocyanins in cancer prevention and treatment. Anthocyanins 115-127 erb-b2 receptor tyrosine kinase 2 Homo sapiens 79-84 24741320-2 2014 Modulation of CYP3A4 by flavonoids, such as anthocyanins, has been shown to inhibit the mutagenic activity of mammalian cells. Anthocyanins 44-56 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 14-20 24741320-3 2014 Considering the previous investigations addressing CYP3A4 inhibition by these substances, we studied the three-dimensional quantitative structure-activity relationship (3D-QSAR) in a series of anthocyanin derivatives as CYP3A4 inhibitors. Anthocyanins 193-204 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 51-57 24741320-3 2014 Considering the previous investigations addressing CYP3A4 inhibition by these substances, we studied the three-dimensional quantitative structure-activity relationship (3D-QSAR) in a series of anthocyanin derivatives as CYP3A4 inhibitors. Anthocyanins 193-204 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 220-226 24659995-6 2014 CPC is also known to be involved in anthocyanin biosynthesis. Anthocyanins 36-47 Homeodomain-like superfamily protein Arabidopsis thaliana 0-3 24285687-9 2014 Furthermore, a strong positive correlation was noted between increased HDL-PON1 activity and improved cholesterol efflux capacity both before and after adjustment for HDL cholesterol and apolipoprotein AI in anthocyanin-treated subjects (both P < .001). Anthocyanins 208-219 paraoxonase 1 Homo sapiens 75-79 24285687-10 2014 Inhibition of HDL-PON1 activity strongly prevented the antioxidant ability of HDL and attenuated the cholesterol efflux capacity of subjects from anthocyanin group. Anthocyanins 146-157 paraoxonase 1 Homo sapiens 18-22 24285687-11 2014 CONCLUSIONS: Our observations suggest that the alterations of PON1 activity by anthocyanin observed in hypercholesterolemic HDL reflect a shift to an improvement of cholesterol efflux capacity of HDL and may provide a link between anthocyanin and cardioprotective effects. Anthocyanins 79-90 paraoxonase 1 Homo sapiens 62-66 24285687-11 2014 CONCLUSIONS: Our observations suggest that the alterations of PON1 activity by anthocyanin observed in hypercholesterolemic HDL reflect a shift to an improvement of cholesterol efflux capacity of HDL and may provide a link between anthocyanin and cardioprotective effects. Anthocyanins 231-242 paraoxonase 1 Homo sapiens 62-66 24336456-0 2014 Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. Anthocyanins 11-23 insulin Homo sapiens 71-78 24336456-7 2014 Anthocyanin-rich foods were also associated with lower insulin and inflammation levels. Anthocyanins 0-11 insulin Homo sapiens 55-62 24336456-9 2014 Higher intakes of both anthocyanins and flavones were associated with improvements in insulin resistance and hs-CRP. Anthocyanins 23-35 insulin Homo sapiens 86-93 24353343-3 2014 Compared with the RG diet, the MYB10 diet contained elevated concentrations of the flavonoid subclasses anthocyanins, flavanol monomers (epicatechin) and oligomers (procyanidin B2), and flavonols (quercetin glycosides), but other plant secondary metabolites were largely unaltered. Anthocyanins 104-116 transcription factor MYB113-like Malus domestica 31-36 24388610-3 2014 In Arabidopsis thaliana, GL3, a bHLH transcription factor, is important in the MBW complex regulating trichome formation as well as in the MBW complex induced by nitrogen depletion and promoting anthocyanin formation. Anthocyanins 195-206 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 25-28 24387788-0 2014 Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes. Anthocyanins 11-25 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 89-95 24387788-0 2014 Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes. Anthocyanins 11-25 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 97-103 24387788-0 2014 Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes. Anthocyanins 11-25 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 105-111 24387788-0 2014 Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes. Anthocyanins 11-25 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 117-123 24387788-0 2014 Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes. Anthocyanins 30-42 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 89-95 24387788-0 2014 Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes. Anthocyanins 30-42 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 97-103 24387788-0 2014 Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes. Anthocyanins 30-42 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 105-111 24387788-0 2014 Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes. Anthocyanins 30-42 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 117-123 24387788-3 2014 The current study evaluated the effects of anthocyanidins and anthocyanins on the expression and catalytic activity of major drug-metabolizing enzymes CYP2C9, CYP2A6, CYP2B6, and CYP3A4 in primary cultures of human hepatocytes and human liver microsomes. Anthocyanins 43-57 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 151-157 24387788-3 2014 The current study evaluated the effects of anthocyanidins and anthocyanins on the expression and catalytic activity of major drug-metabolizing enzymes CYP2C9, CYP2A6, CYP2B6, and CYP3A4 in primary cultures of human hepatocytes and human liver microsomes. Anthocyanins 43-57 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 159-165 24387788-3 2014 The current study evaluated the effects of anthocyanidins and anthocyanins on the expression and catalytic activity of major drug-metabolizing enzymes CYP2C9, CYP2A6, CYP2B6, and CYP3A4 in primary cultures of human hepatocytes and human liver microsomes. Anthocyanins 43-57 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 167-173 24387788-3 2014 The current study evaluated the effects of anthocyanidins and anthocyanins on the expression and catalytic activity of major drug-metabolizing enzymes CYP2C9, CYP2A6, CYP2B6, and CYP3A4 in primary cultures of human hepatocytes and human liver microsomes. Anthocyanins 62-74 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 151-157 24387788-3 2014 The current study evaluated the effects of anthocyanidins and anthocyanins on the expression and catalytic activity of major drug-metabolizing enzymes CYP2C9, CYP2A6, CYP2B6, and CYP3A4 in primary cultures of human hepatocytes and human liver microsomes. Anthocyanins 62-74 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 159-165 24387788-3 2014 The current study evaluated the effects of anthocyanidins and anthocyanins on the expression and catalytic activity of major drug-metabolizing enzymes CYP2C9, CYP2A6, CYP2B6, and CYP3A4 in primary cultures of human hepatocytes and human liver microsomes. Anthocyanins 62-74 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 167-173 24387788-3 2014 The current study evaluated the effects of anthocyanidins and anthocyanins on the expression and catalytic activity of major drug-metabolizing enzymes CYP2C9, CYP2A6, CYP2B6, and CYP3A4 in primary cultures of human hepatocytes and human liver microsomes. Anthocyanins 62-74 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 179-185 24387788-8 2014 Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by >90% at 100 muM with IC50 = 32 muM). Anthocyanins 89-103 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 24-30 24387788-8 2014 Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by >90% at 100 muM with IC50 = 32 muM). Anthocyanins 89-103 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 32-38 24387788-8 2014 Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by >90% at 100 muM with IC50 = 32 muM). Anthocyanins 89-103 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 40-46 24387788-8 2014 Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by >90% at 100 muM with IC50 = 32 muM). Anthocyanins 89-103 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 52-58 24387788-8 2014 Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by >90% at 100 muM with IC50 = 32 muM). Anthocyanins 89-103 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 153-159 24387788-8 2014 Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by >90% at 100 muM with IC50 = 32 muM). Anthocyanins 89-103 latexin Homo sapiens 178-181 24387788-8 2014 Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by >90% at 100 muM with IC50 = 32 muM). Anthocyanins 89-103 latexin Homo sapiens 197-200 24466010-4 2014 Here, we describe a litchi R2R3-MYB transcription factor gene, LcMYB1, which demonstrates a similar sequence as other known anthocyanin regulators. Anthocyanins 124-135 myb-related protein 3R-1-like Nicotiana tabacum 32-35 24466010-13 2014 The upregulation of NtAn1b in response to LcMYB1 overexpression seems to be essential for anthocyanin accumulation in the leaf and pedicel. Anthocyanins 90-101 basic helix-loop-helix protein A-like Nicotiana tabacum 20-26 24466010-14 2014 In the reproductive tissues of transgenic tobacco, however, increased anthocyanin accumulation is independent of tobacco"s endogenous MYB and bHLH transcriptional factors, but associated with the upregulation of specific structural genes. Anthocyanins 70-81 myb-related protein 3R-1-like Nicotiana tabacum 134-137 24054266-2 2014 To improve the stability of anthocyanins in neutral to weakly acidic pH region, effects of metal cations and polysaccharides on the colour stability of cyanidin-3-glucoside (C3G) were examined by ultraviolet-visible and resonance Raman spectroscopies. Anthocyanins 28-40 Rap guanine nucleotide exchange factor 1 Homo sapiens 152-177 24406039-1 2014 BACKGROUND: In Arabidopsis thaliana (A. thaliana) the WD40 protein TRANSPARENT TESTA GLABRA1 (TTG1) controls five traits relevant for the adaptation of plants to environmental changes including the production of proanthocyanidin, anthocyanidin, seed coat mucilage, trichomes and root hairs. Anthocyanins 215-228 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 67-92 24406039-1 2014 BACKGROUND: In Arabidopsis thaliana (A. thaliana) the WD40 protein TRANSPARENT TESTA GLABRA1 (TTG1) controls five traits relevant for the adaptation of plants to environmental changes including the production of proanthocyanidin, anthocyanidin, seed coat mucilage, trichomes and root hairs. Anthocyanins 215-228 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 94-98 24666969-3 2014 It was found that Hep3B hepato-carcinoma cells respond to anthocyanins through GSK3-beta-induced suppression of beta-catenin; however, they cannot dephosphorylate GSK3-beta without AMPK activation. Anthocyanins 58-70 glycogen synthase kinase 3 beta Homo sapiens 79-88 24666969-3 2014 It was found that Hep3B hepato-carcinoma cells respond to anthocyanins through GSK3-beta-induced suppression of beta-catenin; however, they cannot dephosphorylate GSK3-beta without AMPK activation. Anthocyanins 58-70 catenin beta 1 Homo sapiens 112-124 24666969-4 2014 METHODS: We tested the effects of anthocyanins on proliferation and apoptosis by MTT and Annexin V-PI staining in vitro. Anthocyanins 34-46 annexin A5 Homo sapiens 89-98 24666969-7 2014 RESULTS: Anthocyanins decrease phospho-GSK3-beta and beta-catenin expression in an in vivo tumor xenograft model, increase AMPK activity in this model, and inhibit cell migration and invasion, possibly by inhibiting MMP-2 (in vitro) and the panendothelial marker, CD31 (in vivo). Anthocyanins 9-21 glycogen synthase kinase 3 beta Homo sapiens 39-48 24285687-0 2014 Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia. Anthocyanins 0-11 paraoxonase 1 Homo sapiens 52-65 24666969-7 2014 RESULTS: Anthocyanins decrease phospho-GSK3-beta and beta-catenin expression in an in vivo tumor xenograft model, increase AMPK activity in this model, and inhibit cell migration and invasion, possibly by inhibiting MMP-2 (in vitro) and the panendothelial marker, CD31 (in vivo). Anthocyanins 9-21 catenin beta 1 Homo sapiens 53-65 24666969-7 2014 RESULTS: Anthocyanins decrease phospho-GSK3-beta and beta-catenin expression in an in vivo tumor xenograft model, increase AMPK activity in this model, and inhibit cell migration and invasion, possibly by inhibiting MMP-2 (in vitro) and the panendothelial marker, CD31 (in vivo). Anthocyanins 9-21 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 123-127 24285687-2 2014 The aim of the present study was to investigate the effects of anthocyanins on the HDL-PON1 activity and cholesterol efflux capacity in hypercholesterolemic subjects. Anthocyanins 63-75 paraoxonase 1 Homo sapiens 87-91 24666969-7 2014 RESULTS: Anthocyanins decrease phospho-GSK3-beta and beta-catenin expression in an in vivo tumor xenograft model, increase AMPK activity in this model, and inhibit cell migration and invasion, possibly by inhibiting MMP-2 (in vitro) and the panendothelial marker, CD31 (in vivo). Anthocyanins 9-21 matrix metallopeptidase 2 Homo sapiens 216-221 24285687-6 2014 Anthocyanin supplementation also increased the activity of HDL-PON1 compared with placebo (P < .001). Anthocyanins 0-11 paraoxonase 1 Homo sapiens 63-67 24666969-7 2014 RESULTS: Anthocyanins decrease phospho-GSK3-beta and beta-catenin expression in an in vivo tumor xenograft model, increase AMPK activity in this model, and inhibit cell migration and invasion, possibly by inhibiting MMP-2 (in vitro) and the panendothelial marker, CD31 (in vivo). Anthocyanins 9-21 platelet and endothelial cell adhesion molecule 1 Homo sapiens 264-268 24666969-9 2014 Further, we showed that AMPK siRNA treatment abrogated the ability of anthocyanins to control cell proliferation and metastatic potential, and Compound C, an AMPK inhibitor, could not restore GSK3-beta regulation, as exhibited by anthocyanins in Hep3B cells. Anthocyanins 70-82 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 24-28 24666969-10 2014 CONCLUSION: These observations imply that the AMPK-mediated GSK3-beta/beta-catenin circuit plays crucial roles in inhibiting cancer cell proliferation and metastasis in anthocyanin-treated hepato-carcinoma cells of Meoru origin. Anthocyanins 169-180 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 46-50 24666969-10 2014 CONCLUSION: These observations imply that the AMPK-mediated GSK3-beta/beta-catenin circuit plays crucial roles in inhibiting cancer cell proliferation and metastasis in anthocyanin-treated hepato-carcinoma cells of Meoru origin. Anthocyanins 169-180 glycogen synthase kinase 3 beta Homo sapiens 60-69 24666969-10 2014 CONCLUSION: These observations imply that the AMPK-mediated GSK3-beta/beta-catenin circuit plays crucial roles in inhibiting cancer cell proliferation and metastasis in anthocyanin-treated hepato-carcinoma cells of Meoru origin. Anthocyanins 169-180 catenin beta 1 Homo sapiens 70-82 25124601-0 2014 Anti-metastasis activity of black rice anthocyanins against breast cancer: analyses using an ErbB2 positive breast cancer cell line and tumoral xenograft model. Anthocyanins 39-51 erb-b2 receptor tyrosine kinase 2 Homo sapiens 93-98 26019484-3 2014 UFGT is the key enzyme of the anthocyanin biosynthetic pathway. Anthocyanins 30-41 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 0-4 25124601-3 2014 MATERIALS AND METHODS: The present experiments investigated the anti-metastasis effects of black rice anthocyanins (BRACs) on ErbB2 positive breast cancer cells in vivo and in vitro. Anthocyanins 102-114 erb-b2 receptor tyrosine kinase 2 Homo sapiens 126-131 23701564-6 2014 Intake of representative polyphenols (flavones, flavone-3-ols, catechins, anthocyanidins, flavanones, procyanidins, and resveratrol) can improve a skewed Th1/Th2 balance and suppress antigen-specific IgE antibody formation. Anthocyanins 74-88 negative elongation factor complex member C/D Homo sapiens 154-157 25036132-3 2014 In this study, we found that cyanidin-3-glucoside chloride (C3G), an anthocyanin suppressed IL-4 and IL-13 produced in activated EL-4 T cells but not Th1 cytokines including IL-2, interferon-gamma, or IL-12. Anthocyanins 69-80 interleukin 4 Mus musculus 92-96 25036132-3 2014 In this study, we found that cyanidin-3-glucoside chloride (C3G), an anthocyanin suppressed IL-4 and IL-13 produced in activated EL-4 T cells but not Th1 cytokines including IL-2, interferon-gamma, or IL-12. Anthocyanins 69-80 interleukin 13 Mus musculus 101-106 25401758-0 2014 Bilberry-derived anthocyanins prevent IFN-gamma-induced pro-inflammatory signalling and cytokine secretion in human THP-1 monocytic cells. Anthocyanins 17-29 interferon gamma Homo sapiens 38-47 24899909-0 2014 In Silico Insight into Potent of Anthocyanin Regulation of FKBP52 to Prevent Alzheimer"s Disease. Anthocyanins 33-44 FKBP prolyl isomerase 4 Homo sapiens 59-65 24899909-9 2014 The results indicate that anthocyanins might change the conformation of FKBP52 during binding. Anthocyanins 26-38 FKBP prolyl isomerase 4 Homo sapiens 72-78 24899909-10 2014 In addition, the purple anthocyanins, such as cyanidin-3-glucoside and malvidin-3-glucoside, might be better than FK506 in regulating FKBP52 and treating Alzheimer"s disease. Anthocyanins 24-36 FKBP prolyl isomerase 4 Homo sapiens 134-140 24308601-6 2013 Overexpression of TcANR in an Arabidopsis ban mutant complemented the PA deficient phenotype in seeds and resulted in reduced anthocyanidin levels in hypocotyls. Anthocyanins 126-139 anthocyanidin reductase Theobroma cacao 18-23 23815082-4 2014 The present review summarizes the interactions of flavonoids categorized as flavanol, flavonol, flavone, isoflavone, flavanones, and anthocyanidins with SAs (bovine serum albumin and human serum albumin) in light of SAR. Anthocyanins 133-147 albumin Homo sapiens 189-202 24393776-4 2014 Three R2R3-MYB proteins (MYB11, MYB12, and MYB111) control flavonol biosynthesis via activating the early biosynthetic steps, whereas the production of anthocyanins and PAs requires the MYB-bHLH-WD40 (MBW) complex to activate the late biosynthetic genes. Anthocyanins 152-164 myb domain protein 11 Arabidopsis thaliana 25-30 24393776-4 2014 Three R2R3-MYB proteins (MYB11, MYB12, and MYB111) control flavonol biosynthesis via activating the early biosynthetic steps, whereas the production of anthocyanins and PAs requires the MYB-bHLH-WD40 (MBW) complex to activate the late biosynthetic genes. Anthocyanins 152-164 myb domain protein 12 Arabidopsis thaliana 32-37 24393776-4 2014 Three R2R3-MYB proteins (MYB11, MYB12, and MYB111) control flavonol biosynthesis via activating the early biosynthetic steps, whereas the production of anthocyanins and PAs requires the MYB-bHLH-WD40 (MBW) complex to activate the late biosynthetic genes. Anthocyanins 152-164 myb domain protein 111 Arabidopsis thaliana 43-49 24399137-2 2014 The F-box protein CORONATINE INSENSITIVE 1 (COI1) perceives JA signals to mediate diverse plant responses including male fertility, root growth, anthocyanin accumulation, and defense against abiotic and biotic stresses. Anthocyanins 145-156 RNI-like superfamily protein Arabidopsis thaliana 18-42 24399137-2 2014 The F-box protein CORONATINE INSENSITIVE 1 (COI1) perceives JA signals to mediate diverse plant responses including male fertility, root growth, anthocyanin accumulation, and defense against abiotic and biotic stresses. Anthocyanins 145-156 RNI-like superfamily protein Arabidopsis thaliana 44-48 24277841-6 2013 Phenotypically, the plants expressing UVR8(W285A) exhibit constitutive photomorphogenesis associated with constitutive activation of target genes, elevated levels of anthocyanins, and enhanced, acclimation-independent UV-B tolerance. Anthocyanins 166-178 Regulator of chromosome condensation (RCC1) family protein Arabidopsis thaliana 38-42 24308601-7 2013 Overexpression of TcANS in tobacco resulted in increased content of both anthocyanidins and PAs in flower petals. Anthocyanins 73-87 leucoanthocyanidin dioxygenase Theobroma cacao 18-23 24308601-9 2013 Recombinant TcLAR protein converted leucoanthocyanidin to catechin in vitro. Anthocyanins 36-54 leucoanthocyanidin reductase Theobroma cacao 12-17 24308601-10 2013 Transgenic tobacco overexpressing TcLAR had decreased amounts of anthocyanidins and increased PAs. Anthocyanins 65-79 leucoanthocyanidin reductase Theobroma cacao 34-39 24298902-5 2013 The sequencing of the coding region of the UFGT nuclear gene (UDP-glucose: flavonoid 3-0-glucosyltransferase, the key enzyme for the accumulation of anthocyanins in berry skins) enabled the discovery of discriminant SNPs (1/34 bp) and the reconstruction of 130 V. vinifera distinct genotypes. Anthocyanins 149-161 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 43-47 24312561-0 2013 Selective anti-proliferation of HER2-positive breast cancer cells by anthocyanins identified by high-throughput screening. Anthocyanins 69-81 erb-b2 receptor tyrosine kinase 2 Homo sapiens 32-36 23870958-0 2013 Interaction of anthocyanins with human serum albumin: influence of pH and chemical structure on binding. Anthocyanins 15-27 albumin Homo sapiens 39-52 23870958-1 2013 The affinity of anthocyanins for human serum albumin (HSA) was determined by a fluorescence quenching method. Anthocyanins 16-28 albumin Homo sapiens 39-52 24118612-4 2013 Seedlings and seeds of mTCP3 plants were found to hyper-accumulate flavonols, anthocyanins and proanthocyanidins, whereas levels of proanthocyanidins were slightly reduced in TCP3SRDX plants. Anthocyanins 78-90 t-complex protein 3 Mus musculus 23-28 24118612-4 2013 Seedlings and seeds of mTCP3 plants were found to hyper-accumulate flavonols, anthocyanins and proanthocyanidins, whereas levels of proanthocyanidins were slightly reduced in TCP3SRDX plants. Anthocyanins 78-90 chaperonin-containing T-complex subunit CCT3 Saccharomyces cerevisiae S288C 24-28 23925404-0 2013 The Arabidopsis thaliana mutant air1 implicates SOS3 in the regulation of anthocyanins under salt stress. Anthocyanins 74-86 Calcium-binding EF-hand family protein Arabidopsis thaliana 48-52 23784800-0 2013 Role of anthocyanin-enriched purple-fleshed sweet potato p40 in colorectal cancer prevention. Anthocyanins 8-19 interleukin 9 Homo sapiens 57-60 23784800-3 2013 METHODS AND RESULTS: We selected an anthocyanin-enriched purple-fleshed sweet potato clone, P40, and investigated its potential anticancer effect in both in vitro cell culture and in vivo animal model. Anthocyanins 36-47 interleukin 9 Homo sapiens 92-95 23784800-4 2013 In addition to a high level of total phenolics and antioxidant capacity, P40 possesses a high content of anthocyanins at 7.5 mg/g dry matter. Anthocyanins 105-117 interleukin 9 Homo sapiens 73-76 23784800-5 2013 Treatment of human colonic SW480 cancer cells with P40 anthocyanin extracts at 0-40 muM of peonidin-3-glucoside equivalent resulted in a dose-dependent decrease in cell number due to cytostatic arrest of cell cycle at G1 phase but not cytotoxicity. Anthocyanins 55-66 interleukin 9 Homo sapiens 51-54 23784800-7 2013 CONCLUSION: These observations, coupled with both in vitro and in vivo studies reported here, suggest anthocyanin-enriched sweet potato P40 may protect against colorectal cancer by inducing cell-cycle arrest, antiproliferative, and apoptotic mechanisms. Anthocyanins 102-113 interleukin 9 Homo sapiens 136-139 23937661-3 2013 CHALCONE SYNTHASE (CHS) was selected as a target in Arabidopsis thaliana due to the obvious and non-lethal loss of anthocyanin accumulation upon widespread RNA silencing. Anthocyanins 115-126 Chalcone and stilbene synthase family protein Arabidopsis thaliana 0-17 23830691-0 2013 Anthocyanins attenuate body weight gain via modulating neuropeptide Y and GABAB1 receptor in rats hypothalamus. Anthocyanins 0-12 neuropeptide Y Rattus norvegicus 55-69 24177565-0 2013 Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Anthocyanins 49-61 growth arrest and DNA damage inducible alpha Homo sapiens 20-26 24177565-0 2013 Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Anthocyanins 49-61 MDM2 proto-oncogene Homo sapiens 31-35 24204712-1 2013 The I locus is a 27-kb inverted repeat cluster of chalcone synthase genes CHS1-3-4 that mediates siRNA down-regulation of CHS7 and CHS8 target mRNAs during seed development leading to yellow seed coats lacking anthocyanin pigments. Anthocyanins 210-221 chalcone synthase 1 Glycine max 74-78 24204712-1 2013 The I locus is a 27-kb inverted repeat cluster of chalcone synthase genes CHS1-3-4 that mediates siRNA down-regulation of CHS7 and CHS8 target mRNAs during seed development leading to yellow seed coats lacking anthocyanin pigments. Anthocyanins 210-221 chalcone synthase Glycine max 131-135 24124611-2 2013 In the present study, we found that delphinidin, an anthocyanidin, present in pigmented fruits and vegetables, is a potent inhibitor of both EGFR and VEGFR2 in NSCLC cells that overexpress EGFR/VEGFR2. Anthocyanins 52-65 kinase insert domain receptor Homo sapiens 150-156 24124611-2 2013 In the present study, we found that delphinidin, an anthocyanidin, present in pigmented fruits and vegetables, is a potent inhibitor of both EGFR and VEGFR2 in NSCLC cells that overexpress EGFR/VEGFR2. Anthocyanins 52-65 epidermal growth factor receptor Homo sapiens 151-155 23407247-9 2013 The VEGF in the anthocyanin-treated groups increased, whereas TSP1 decreased. Anthocyanins 16-27 vascular endothelial growth factor A Homo sapiens 4-8 23407247-11 2013 Anthocyanins inhibited the translocation of nuclear factor-kappaB (p65) from cytosol to nucleus and also prevented the phosphorylation of IkappaBalpha. Anthocyanins 0-12 RELA proto-oncogene, NF-kB subunit Homo sapiens 67-70 23407247-11 2013 Anthocyanins inhibited the translocation of nuclear factor-kappaB (p65) from cytosol to nucleus and also prevented the phosphorylation of IkappaBalpha. Anthocyanins 0-12 NFKB inhibitor alpha Homo sapiens 138-150 23830691-7 2013 Western blot analysis showed that high dose of anthocyanins treatment significantly reduced the expression of neuropeptide Y (NPY) and increased gamma-amino butyric acid receptor (GABAB1R) in hypothalamus. Anthocyanins 47-59 neuropeptide Y Rattus norvegicus 110-124 23830691-7 2013 Western blot analysis showed that high dose of anthocyanins treatment significantly reduced the expression of neuropeptide Y (NPY) and increased gamma-amino butyric acid receptor (GABAB1R) in hypothalamus. Anthocyanins 47-59 neuropeptide Y Rattus norvegicus 126-129 23830691-9 2013 These data support the concept that anthocyanins even in normal circumstances have the capability to reduce body weight and food intake through its modulatory effect on NPY and GABAB1R in hypothalamus. Anthocyanins 36-48 neuropeptide Y Rattus norvegicus 169-172 22906565-4 2013 Anthocyanin consumption significantly decreased the levels of serum high sensitivity C-reactive protein (hsCRP) (-21.6% vs. -2.5%, P = 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1) (-12.3% vs. 0.4%, P = 0.005) and plasma IL-1beta (-12.8% vs. -1.3%, P = 0.019) compared to the placebo. Anthocyanins 0-11 C-reactive protein Homo sapiens 85-103 23930663-0 2013 Anthocyanins from Chinese bayberry extract activate transcription factor Nrf2 in beta cells and negatively regulate oxidative stress-induced autophagy. Anthocyanins 0-12 NFE2 like bZIP transcription factor 2 Rattus norvegicus 73-77 23930663-3 2013 We have shown previously that anthocyanins in Chinese bayberry extract protected beta cells (INS-1) from hydrogen peroxide (H2O2)-induced apoptosis and decreased grafts" apoptosis after transplantation partially through heme oxygenase-1 (HO-1) up-regulation. Anthocyanins 30-42 insulin 1 Rattus norvegicus 93-98 23930663-3 2013 We have shown previously that anthocyanins in Chinese bayberry extract protected beta cells (INS-1) from hydrogen peroxide (H2O2)-induced apoptosis and decreased grafts" apoptosis after transplantation partially through heme oxygenase-1 (HO-1) up-regulation. Anthocyanins 30-42 heme oxygenase 1 Rattus norvegicus 238-242 23930663-7 2013 Anthocyanins activated antioxidant transcription factor Nrf2 in INS-1 cells, and Nrf2/HO-1 negatively regulated autophagy process. Anthocyanins 0-12 NFE2 like bZIP transcription factor 2 Rattus norvegicus 56-60 23930663-7 2013 Anthocyanins activated antioxidant transcription factor Nrf2 in INS-1 cells, and Nrf2/HO-1 negatively regulated autophagy process. Anthocyanins 0-12 insulin 1 Rattus norvegicus 64-69 23471845-1 2013 BACKGROUND: Black rice is rich in anthocyanins, especially cyanidin-3-glucoside (C3G). Anthocyanins 34-46 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 81-84 23658065-5 2013 Loss of APT1 activity in plants leads to excess accumulation of cytokinin bases, thus evoking myriad cytokinin-regulated responses, such as delayed leaf senescence, anthocyanin accumulation, and downstream gene expression. Anthocyanins 165-176 adenine phosphoribosyl transferase 1 Arabidopsis thaliana 8-12 22906565-4 2013 Anthocyanin consumption significantly decreased the levels of serum high sensitivity C-reactive protein (hsCRP) (-21.6% vs. -2.5%, P = 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1) (-12.3% vs. 0.4%, P = 0.005) and plasma IL-1beta (-12.8% vs. -1.3%, P = 0.019) compared to the placebo. Anthocyanins 0-11 vascular cell adhesion molecule 1 Homo sapiens 151-184 22906565-4 2013 Anthocyanin consumption significantly decreased the levels of serum high sensitivity C-reactive protein (hsCRP) (-21.6% vs. -2.5%, P = 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1) (-12.3% vs. 0.4%, P = 0.005) and plasma IL-1beta (-12.8% vs. -1.3%, P = 0.019) compared to the placebo. Anthocyanins 0-11 interleukin 1 beta Homo sapiens 235-243 23774374-5 2013 Genes involved in the later steps of the anthocyanin pathway (dihydrokaempferol reductase 2, UDP-glucose:anthocyanin 3-O-glucosyltransferase and glutathione S-transferase) were found under-expressed in both mutants. Anthocyanins 41-52 glutathione S-transferase L3-like Medicago truncatula 145-170 23666061-9 2013 The CmMYB1 shared high similarity with AtMYB4 and AtMYBL2 which is a negative regulator of anthocyanin and flavonol accumulation. Anthocyanins 91-102 MYB-like 2 Arabidopsis thaliana 50-57 23940555-5 2013 erf6 insertion mutant plants showed reduced growth and increased H2O2 and anthocyanin levels. Anthocyanins 74-85 ethylene responsive element binding factor 6 Arabidopsis thaliana 0-4 23645118-5 2013 The ability of anthocyanins to reverse the effects of ethanol on cellular levels of Bax, Bcl-2, active caspase-3, cleaved PARP-1, GABAB1R, and CaMKII were abrogated in cells transfected with GABAB1R siRNA. Anthocyanins 15-27 BCL2 associated X, apoptosis regulator Rattus norvegicus 84-87 23645118-5 2013 The ability of anthocyanins to reverse the effects of ethanol on cellular levels of Bax, Bcl-2, active caspase-3, cleaved PARP-1, GABAB1R, and CaMKII were abrogated in cells transfected with GABAB1R siRNA. Anthocyanins 15-27 BCL2, apoptosis regulator Rattus norvegicus 89-94 23645118-5 2013 The ability of anthocyanins to reverse the effects of ethanol on cellular levels of Bax, Bcl-2, active caspase-3, cleaved PARP-1, GABAB1R, and CaMKII were abrogated in cells transfected with GABAB1R siRNA. Anthocyanins 15-27 caspase 3 Rattus norvegicus 103-112 23645118-5 2013 The ability of anthocyanins to reverse the effects of ethanol on cellular levels of Bax, Bcl-2, active caspase-3, cleaved PARP-1, GABAB1R, and CaMKII were abrogated in cells transfected with GABAB1R siRNA. Anthocyanins 15-27 poly (ADP-ribose) polymerase 1 Rattus norvegicus 122-128 23570521-10 2013 Moreover, anthocyanin-inhibited melanin synthesis occurs through the inhibition of tyrosinase enzymatic activity and suppression of the protein expression of tyrosinase and MITF. Anthocyanins 10-21 tyrosinase Homo sapiens 83-93 23570521-10 2013 Moreover, anthocyanin-inhibited melanin synthesis occurs through the inhibition of tyrosinase enzymatic activity and suppression of the protein expression of tyrosinase and MITF. Anthocyanins 10-21 tyrosinase Homo sapiens 158-168 23570521-10 2013 Moreover, anthocyanin-inhibited melanin synthesis occurs through the inhibition of tyrosinase enzymatic activity and suppression of the protein expression of tyrosinase and MITF. Anthocyanins 10-21 melanocyte inducing transcription factor Homo sapiens 173-177 23735880-0 2013 Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. Anthocyanins 11-23 aryl hydrocarbon receptor Homo sapiens 31-34 23320385-0 2013 Inhibitory effect of anthocyanidins on hepatic glutathione S-transferase, UDP-glucuronosyltransferase and carbonyl reductase activities in rat and human. Anthocyanins 21-35 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 74-101 23320385-0 2013 Inhibitory effect of anthocyanidins on hepatic glutathione S-transferase, UDP-glucuronosyltransferase and carbonyl reductase activities in rat and human. Anthocyanins 21-35 dehydrogenase/reductase 4 Rattus norvegicus 106-124 23320385-3 2013 The aim of this study was to evaluate inhibitory effect of four anthocyanidins (delphinidin, cyanidin, malvidin and pelargonidin) on three families of important drug-metabolizing enzymes: carbonyl reductases (CBRs), glutathione S-transferases (GSTs) and UDP-glucuronosyltransferases (UGT). Anthocyanins 64-78 beta-1,3-glucuronyltransferase 2 Homo sapiens 254-282 23320385-3 2013 The aim of this study was to evaluate inhibitory effect of four anthocyanidins (delphinidin, cyanidin, malvidin and pelargonidin) on three families of important drug-metabolizing enzymes: carbonyl reductases (CBRs), glutathione S-transferases (GSTs) and UDP-glucuronosyltransferases (UGT). Anthocyanins 64-78 beta-1,3-glucuronyltransferase 2 Homo sapiens 284-287 23320385-8 2013 Anthocyanidins inhibited weakly the activity of GST and moderately the activities of CBR and UGT. Anthocyanins 0-14 carbonyl reductase 1 Homo sapiens 85-88 23320385-8 2013 Anthocyanidins inhibited weakly the activity of GST and moderately the activities of CBR and UGT. Anthocyanins 0-14 beta-1,3-glucuronyltransferase 2 Homo sapiens 93-96 23320385-13 2013 Anthocyanidins are able to inhibit CBR and UGT in vitro. Anthocyanins 0-14 carbonyl reductase 1 Homo sapiens 35-38 23320385-13 2013 Anthocyanidins are able to inhibit CBR and UGT in vitro. Anthocyanins 0-14 beta-1,3-glucuronyltransferase 2 Homo sapiens 43-46 23320385-14 2013 Possible interference of anthocyanidins (in high-dose dietary supplements) with simultaneously administered drugs, which are UGT or CBR substrates, should be checked. Anthocyanins 25-39 beta-1,3-glucuronyltransferase 2 Homo sapiens 125-128 23320385-14 2013 Possible interference of anthocyanidins (in high-dose dietary supplements) with simultaneously administered drugs, which are UGT or CBR substrates, should be checked. Anthocyanins 25-39 carbonyl reductase 1 Homo sapiens 132-135 23735880-0 2013 Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. Anthocyanins 11-23 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-41 23735880-2 2013 Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 signaling pathway in human hepatocytes and human hepatic HepG2 and intestinal LS174T cancer cells. Anthocyanins 107-119 aryl hydrocarbon receptor Homo sapiens 192-217 23735880-2 2013 Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 signaling pathway in human hepatocytes and human hepatic HepG2 and intestinal LS174T cancer cells. Anthocyanins 172-184 aryl hydrocarbon receptor Homo sapiens 192-217 23735880-2 2013 Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 signaling pathway in human hepatocytes and human hepatic HepG2 and intestinal LS174T cancer cells. Anthocyanins 172-184 aryl hydrocarbon receptor Homo sapiens 219-222 23735880-2 2013 Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 signaling pathway in human hepatocytes and human hepatic HepG2 and intestinal LS174T cancer cells. Anthocyanins 172-184 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 224-246 23689818-4 2013 Conversely the closely related MYB PAP4 (AtMYB114) regulates the anthocyanin pathway and specifically activates UFGT (UDP-glucose:flavonoid-3-O-glucosyltransferase), encoding the first enzyme of the anthocyanin pathway. Anthocyanins 65-76 myb domain protein 114 Arabidopsis thaliana 41-49 24244813-2 2013 Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. Anthocyanins 29-41 insulin Mesocricetus auratus 65-72 23229494-0 2013 Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway. Anthocyanins 0-12 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 23229494-6 2013 Furthermore, under normoxic conditions, anthocyanin metabolites appeared able to activate the Nrf2 pathway, through the involvement of specific kinases (ERK1/2); this adaptive effect may explain the protective effect observed in mild hyperoxia-exposed HUVECs following anthocyanin pretreatment. Anthocyanins 40-51 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 23229494-6 2013 Furthermore, under normoxic conditions, anthocyanin metabolites appeared able to activate the Nrf2 pathway, through the involvement of specific kinases (ERK1/2); this adaptive effect may explain the protective effect observed in mild hyperoxia-exposed HUVECs following anthocyanin pretreatment. Anthocyanins 40-51 mitogen-activated protein kinase 3 Homo sapiens 153-159 23229494-6 2013 Furthermore, under normoxic conditions, anthocyanin metabolites appeared able to activate the Nrf2 pathway, through the involvement of specific kinases (ERK1/2); this adaptive effect may explain the protective effect observed in mild hyperoxia-exposed HUVECs following anthocyanin pretreatment. Anthocyanins 269-280 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 23229494-6 2013 Furthermore, under normoxic conditions, anthocyanin metabolites appeared able to activate the Nrf2 pathway, through the involvement of specific kinases (ERK1/2); this adaptive effect may explain the protective effect observed in mild hyperoxia-exposed HUVECs following anthocyanin pretreatment. Anthocyanins 269-280 mitogen-activated protein kinase 3 Homo sapiens 153-159 23645118-3 2013 The results showed that, when ethanol treatment was followed by anthocyanins treatment, cellular levels of proapoptotic proteins such as Bax, activated caspase-3, and cleaved poly (ADP-ribose) polymerase 1 (PARP-1) were decreased, and the cellular level of the antiapoptotic protein Bcl-2 was increased compared to treatment with ethanol alone. Anthocyanins 64-76 BCL2 associated X, apoptosis regulator Rattus norvegicus 137-140 23645118-3 2013 The results showed that, when ethanol treatment was followed by anthocyanins treatment, cellular levels of proapoptotic proteins such as Bax, activated caspase-3, and cleaved poly (ADP-ribose) polymerase 1 (PARP-1) were decreased, and the cellular level of the antiapoptotic protein Bcl-2 was increased compared to treatment with ethanol alone. Anthocyanins 64-76 caspase 3 Rattus norvegicus 152-161 23645118-3 2013 The results showed that, when ethanol treatment was followed by anthocyanins treatment, cellular levels of proapoptotic proteins such as Bax, activated caspase-3, and cleaved poly (ADP-ribose) polymerase 1 (PARP-1) were decreased, and the cellular level of the antiapoptotic protein Bcl-2 was increased compared to treatment with ethanol alone. Anthocyanins 64-76 poly (ADP-ribose) polymerase 1 Rattus norvegicus 175-205 23645118-3 2013 The results showed that, when ethanol treatment was followed by anthocyanins treatment, cellular levels of proapoptotic proteins such as Bax, activated caspase-3, and cleaved poly (ADP-ribose) polymerase 1 (PARP-1) were decreased, and the cellular level of the antiapoptotic protein Bcl-2 was increased compared to treatment with ethanol alone. Anthocyanins 64-76 poly (ADP-ribose) polymerase 1 Rattus norvegicus 207-213 23645118-3 2013 The results showed that, when ethanol treatment was followed by anthocyanins treatment, cellular levels of proapoptotic proteins such as Bax, activated caspase-3, and cleaved poly (ADP-ribose) polymerase 1 (PARP-1) were decreased, and the cellular level of the antiapoptotic protein Bcl-2 was increased compared to treatment with ethanol alone. Anthocyanins 64-76 BCL2, apoptosis regulator Rattus norvegicus 283-288 23689818-4 2013 Conversely the closely related MYB PAP4 (AtMYB114) regulates the anthocyanin pathway and specifically activates UFGT (UDP-glucose:flavonoid-3-O-glucosyltransferase), encoding the first enzyme of the anthocyanin pathway. Anthocyanins 199-210 myb domain protein 114 Arabidopsis thaliana 41-49 23689818-4 2013 Conversely the closely related MYB PAP4 (AtMYB114) regulates the anthocyanin pathway and specifically activates UFGT (UDP-glucose:flavonoid-3-O-glucosyltransferase), encoding the first enzyme of the anthocyanin pathway. Anthocyanins 199-210 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 118-163 23689818-6 2013 Using chimeric and point mutated variants of TT2 and PAP4 we found that exchange of a single amino acid, Gly/Arg(39) in the R2 domain combined with an exchange of a four amino acid motif in the R3 domain, could swap the pathway selection of TT2 and PAP4, thereby converting in planta specificity of the PA towards the anthocyanin pathway and vice versa. Anthocyanins 318-329 Duplicated homeodomain-like superfamily protein Arabidopsis thaliana 45-48 23825152-7 2013 Anthocyanin-rich grape-bilberry juice intervention reduced serum leptin and resistin, but showed no influence on serum adiponectin and secretion of adipokines from mesenteric adipose tissue. Anthocyanins 0-11 leptin Rattus norvegicus 65-71 23825152-7 2013 Anthocyanin-rich grape-bilberry juice intervention reduced serum leptin and resistin, but showed no influence on serum adiponectin and secretion of adipokines from mesenteric adipose tissue. Anthocyanins 0-11 resistin Rattus norvegicus 76-84 23259919-0 2013 Black currant anthocyanins normalized abnormal levels of serum concentrations of endothelin-1 in patients with glaucoma. Anthocyanins 14-26 endothelin 1 Homo sapiens 81-93 23683106-1 2013 Black soybean seed coat has abundant levels of polyphenols such as anthocyanins (cyanidin 3-glucoside; C3G) and procyanidins (PCs). Anthocyanins 67-79 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 103-106 23723987-6 2013 However, unlike protein levels of BDNF, the regional enhancement of BDNF mRNA expression in the hippocampus appeared to be predominantly enhanced by anthocyanins. Anthocyanins 149-161 brain derived neurotrophic factor Homo sapiens 68-72 23583450-0 2013 HY5 regulates anthocyanin biosynthesis by inducing the transcriptional activation of the MYB75/PAP1 transcription factor in Arabidopsis. Anthocyanins 14-25 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 0-3 23583450-0 2013 HY5 regulates anthocyanin biosynthesis by inducing the transcriptional activation of the MYB75/PAP1 transcription factor in Arabidopsis. Anthocyanins 14-25 production of anthocyanin pigment 1 Arabidopsis thaliana 89-94 23583450-0 2013 HY5 regulates anthocyanin biosynthesis by inducing the transcriptional activation of the MYB75/PAP1 transcription factor in Arabidopsis. Anthocyanins 14-25 phosphatidic acid phosphatase 1 Arabidopsis thaliana 95-99 23583450-2 2013 HY5, a component of light-signaling pathways, and PAP1, an R2R3-MYB transcription factor, share common regulatory targets on anthocyanin biosynthesis genes. Anthocyanins 125-136 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 0-3 23583450-2 2013 HY5, a component of light-signaling pathways, and PAP1, an R2R3-MYB transcription factor, share common regulatory targets on anthocyanin biosynthesis genes. Anthocyanins 125-136 phosphatidic acid phosphatase 1 Arabidopsis thaliana 50-54 23583450-5 2013 The results show that HY5 regulates PAP1 expression via direct binding to G- and ACE-boxes in the promoter region, which suggests bifurcate regulation of anthocyanin biosynthesis by HY5 via transcriptional activation of PAP1. Anthocyanins 154-165 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 22-25 23583450-5 2013 The results show that HY5 regulates PAP1 expression via direct binding to G- and ACE-boxes in the promoter region, which suggests bifurcate regulation of anthocyanin biosynthesis by HY5 via transcriptional activation of PAP1. Anthocyanins 154-165 phosphatidic acid phosphatase 1 Arabidopsis thaliana 36-40 23583450-5 2013 The results show that HY5 regulates PAP1 expression via direct binding to G- and ACE-boxes in the promoter region, which suggests bifurcate regulation of anthocyanin biosynthesis by HY5 via transcriptional activation of PAP1. Anthocyanins 154-165 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 182-185 23583450-5 2013 The results show that HY5 regulates PAP1 expression via direct binding to G- and ACE-boxes in the promoter region, which suggests bifurcate regulation of anthocyanin biosynthesis by HY5 via transcriptional activation of PAP1. Anthocyanins 154-165 phosphatidic acid phosphatase 1 Arabidopsis thaliana 220-224 22901316-3 2013 In particular, MYB family transcription factors are emerging as central players in the coordinated activation of sets of genes specific for the anthocyanin and tannin pathways. Anthocyanins 144-155 MYB proto-oncogene, transcription factor Homo sapiens 15-18 23603939-0 2013 Tomato (Solanum lycopersicum) homologs of TRIPTYCHON (SlTRY) and GLABRA3 (SlGL3) are involved in anthocyanin accumulation. Anthocyanins 97-108 Homeodomain-like superfamily protein Arabidopsis thaliana 42-52 23603939-0 2013 Tomato (Solanum lycopersicum) homologs of TRIPTYCHON (SlTRY) and GLABRA3 (SlGL3) are involved in anthocyanin accumulation. Anthocyanins 97-108 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 65-72 23603939-4 2013 CPC and GL3 are also known to be involved in anthocyanin biosynthesis. Anthocyanins 45-56 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 8-11 23603939-5 2013 Here, we show that anthocyanin accumulation was repressed in the CPC::SlTRY and GL3::SlGL3 transgenic plants, suggesting that SlTRY and SlGL3 can influence anthocyanin pigment synthesis. Anthocyanins 19-30 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 80-83 23130849-2 2013 We have raised the polyphenolic content of apple by genetic engineering of the anthocyanin pathway using the apple transcription factor MYB10. Anthocyanins 79-90 transcription factor MYB113-like Malus domestica 136-141 23673982-4 2013 Gain-of-function transgenic plants expressing the chimeric repressor for JAM1 exhibited substantial reduction of JA responses, including JA-induced inhibition of root growth, accumulation of anthocyanin, and male fertility. Anthocyanins 191-202 ABA-inducible BHLH-type transcription factor Arabidopsis thaliana 73-77 23425305-0 2013 Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis. Anthocyanins 132-143 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 34-38 23425305-0 2013 Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis. Anthocyanins 132-143 phosphatidic acid phosphatase 1 Arabidopsis thaliana 106-110 23425305-0 2013 Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis. Anthocyanins 132-143 Purple acid phosphatases superfamily protein Arabidopsis thaliana 115-119 23425305-2 2013 Repression of anthocyanin accumulation in darkness requires the CONSTITUTIVELY PHOTOMORPHOGENIC1/SUPPRESSOR OF PHYA-105 (COP1/SPA) ubiquitin ligase, as cop1 and spa mutants produce anthocyanins also in the dark. Anthocyanins 14-25 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 121-125 23425305-2 2013 Repression of anthocyanin accumulation in darkness requires the CONSTITUTIVELY PHOTOMORPHOGENIC1/SUPPRESSOR OF PHYA-105 (COP1/SPA) ubiquitin ligase, as cop1 and spa mutants produce anthocyanins also in the dark. Anthocyanins 14-25 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 152-156 23425305-2 2013 Repression of anthocyanin accumulation in darkness requires the CONSTITUTIVELY PHOTOMORPHOGENIC1/SUPPRESSOR OF PHYA-105 (COP1/SPA) ubiquitin ligase, as cop1 and spa mutants produce anthocyanins also in the dark. Anthocyanins 181-193 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 121-125 23425305-2 2013 Repression of anthocyanin accumulation in darkness requires the CONSTITUTIVELY PHOTOMORPHOGENIC1/SUPPRESSOR OF PHYA-105 (COP1/SPA) ubiquitin ligase, as cop1 and spa mutants produce anthocyanins also in the dark. Anthocyanins 181-193 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 152-156 23425305-3 2013 Here, we show that COP1 and SPA proteins interact with the myeloblastosis (MYB) transcription factors PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP)1 and PAP2, two members of a small protein family that is required for anthocyanin accumulation and for the expression of structural genes in the anthocyanin biosynthesis pathway. Anthocyanins 213-224 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 19-23 23425305-3 2013 Here, we show that COP1 and SPA proteins interact with the myeloblastosis (MYB) transcription factors PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP)1 and PAP2, two members of a small protein family that is required for anthocyanin accumulation and for the expression of structural genes in the anthocyanin biosynthesis pathway. Anthocyanins 213-224 phosphatidic acid phosphatase 1 Arabidopsis thaliana 102-143 23425305-3 2013 Here, we show that COP1 and SPA proteins interact with the myeloblastosis (MYB) transcription factors PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP)1 and PAP2, two members of a small protein family that is required for anthocyanin accumulation and for the expression of structural genes in the anthocyanin biosynthesis pathway. Anthocyanins 213-224 Purple acid phosphatases superfamily protein Arabidopsis thaliana 148-152 23425305-3 2013 Here, we show that COP1 and SPA proteins interact with the myeloblastosis (MYB) transcription factors PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP)1 and PAP2, two members of a small protein family that is required for anthocyanin accumulation and for the expression of structural genes in the anthocyanin biosynthesis pathway. Anthocyanins 288-299 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 19-23 23425305-3 2013 Here, we show that COP1 and SPA proteins interact with the myeloblastosis (MYB) transcription factors PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP)1 and PAP2, two members of a small protein family that is required for anthocyanin accumulation and for the expression of structural genes in the anthocyanin biosynthesis pathway. Anthocyanins 288-299 phosphatidic acid phosphatase 1 Arabidopsis thaliana 102-143 23425305-3 2013 Here, we show that COP1 and SPA proteins interact with the myeloblastosis (MYB) transcription factors PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP)1 and PAP2, two members of a small protein family that is required for anthocyanin accumulation and for the expression of structural genes in the anthocyanin biosynthesis pathway. Anthocyanins 288-299 Purple acid phosphatases superfamily protein Arabidopsis thaliana 148-152 23425305-4 2013 The increased anthocyanin levels in cop1 mutants requires the PAP1 gene family, indicating that COP1 functions upstream of the PAP1 gene family. Anthocyanins 14-25 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 36-40 23425305-4 2013 The increased anthocyanin levels in cop1 mutants requires the PAP1 gene family, indicating that COP1 functions upstream of the PAP1 gene family. Anthocyanins 14-25 phosphatidic acid phosphatase 1 Arabidopsis thaliana 62-66 23425305-4 2013 The increased anthocyanin levels in cop1 mutants requires the PAP1 gene family, indicating that COP1 functions upstream of the PAP1 gene family. Anthocyanins 14-25 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 96-100 23425305-4 2013 The increased anthocyanin levels in cop1 mutants requires the PAP1 gene family, indicating that COP1 functions upstream of the PAP1 gene family. Anthocyanins 14-25 phosphatidic acid phosphatase 1 Arabidopsis thaliana 127-131 23425305-6 2013 Hence, the light requirement for anthocyanin biosynthesis results, at least in part, from the light-mediated stabilization of PAP1 and PAP2. Anthocyanins 33-44 phosphatidic acid phosphatase 1 Arabidopsis thaliana 126-130 23425305-6 2013 Hence, the light requirement for anthocyanin biosynthesis results, at least in part, from the light-mediated stabilization of PAP1 and PAP2. Anthocyanins 33-44 Purple acid phosphatases superfamily protein Arabidopsis thaliana 135-139 23425305-7 2013 Consistent with this conclusion, moderate overexpression of PAP1 leads to an increase in anthocyanin levels only in the light and not in darkness. Anthocyanins 89-100 phosphatidic acid phosphatase 1 Arabidopsis thaliana 60-64 23425305-10 2013 Thus, our findings have identified mechanisms via which the COP1/SPA complex controls anthocyanin levels in Arabidopsis that may be useful for applications in biotechnology directed towards increasing anthocyanin content in plants. Anthocyanins 86-97 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 60-64 23425305-10 2013 Thus, our findings have identified mechanisms via which the COP1/SPA complex controls anthocyanin levels in Arabidopsis that may be useful for applications in biotechnology directed towards increasing anthocyanin content in plants. Anthocyanins 201-212 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 60-64 22906731-1 2013 Cyanidin 3-glucoside (C3G) is one of the major dietary anthocyanins implicated in the prevention of chronic diseases. Anthocyanins 55-67 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 0-25 23419638-1 2013 We examined the effects of anthocyanidins (cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin) on the aryl hydrocarbon receptor (AhR)-CYP1A1 signaling pathway in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cells. Anthocyanins 27-41 aryl hydrocarbon receptor Homo sapiens 118-143 23419638-1 2013 We examined the effects of anthocyanidins (cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin) on the aryl hydrocarbon receptor (AhR)-CYP1A1 signaling pathway in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cells. Anthocyanins 27-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 150-156 23298714-7 2013 The results from analyses of gene expression and of anthocyanin composition in a knock-out (KO) mutant and from a complementation test indicate that AtBGLU10 might encode this AAGT. Anthocyanins 52-63 beta glucosidase 10 Arabidopsis thaliana 149-157 22684634-9 2013 CONCLUSION: The cholesterol-lowering activity of blueberry anthocyanins was most likely mediated by enhancing the excretion of sterols accompanied with down-regulation on gene expression of intestinal NPC1L1, ACAT-2, MTP, and ABCG 8. Anthocyanins 59-71 NPC1 like intracellular cholesterol transporter 1 Homo sapiens 201-207 23294316-6 2013 Although anthocyanins induced apoptosis in some leukaemia cell lines, the level of caspase-3, caspase-8 and caspase-9 was significantly lower compared with imatinib and 6-MP. Anthocyanins 9-21 caspase 3 Homo sapiens 83-92 23294316-6 2013 Although anthocyanins induced apoptosis in some leukaemia cell lines, the level of caspase-3, caspase-8 and caspase-9 was significantly lower compared with imatinib and 6-MP. Anthocyanins 9-21 caspase 8 Homo sapiens 94-103 23294316-6 2013 Although anthocyanins induced apoptosis in some leukaemia cell lines, the level of caspase-3, caspase-8 and caspase-9 was significantly lower compared with imatinib and 6-MP. Anthocyanins 9-21 caspase 9 Homo sapiens 108-117 22684634-9 2013 CONCLUSION: The cholesterol-lowering activity of blueberry anthocyanins was most likely mediated by enhancing the excretion of sterols accompanied with down-regulation on gene expression of intestinal NPC1L1, ACAT-2, MTP, and ABCG 8. Anthocyanins 59-71 acetyl-CoA acetyltransferase 2 Homo sapiens 209-215 22684634-9 2013 CONCLUSION: The cholesterol-lowering activity of blueberry anthocyanins was most likely mediated by enhancing the excretion of sterols accompanied with down-regulation on gene expression of intestinal NPC1L1, ACAT-2, MTP, and ABCG 8. Anthocyanins 59-71 metallothionein 1B Homo sapiens 217-220 22684634-9 2013 CONCLUSION: The cholesterol-lowering activity of blueberry anthocyanins was most likely mediated by enhancing the excretion of sterols accompanied with down-regulation on gene expression of intestinal NPC1L1, ACAT-2, MTP, and ABCG 8. Anthocyanins 59-71 ATP binding cassette subfamily G member 8 Homo sapiens 226-232 23398515-1 2013 TT8/bHLH042 is a key regulator of anthocyanins and proanthocyanidins (PAs) biosynthesis in Arabidopsis thaliana. Anthocyanins 34-46 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 0-3 22832077-9 2013 The neuroprotective potential of anthocyanins in this particular model is discussed in terms of interaction with rhodopsin/phototransduction and in terms of antioxidative capacity. Anthocyanins 33-45 rhodopsin Rattus norvegicus 113-122 23398515-6 2013 Two modules were found to specifically drive TT8 promoter activity in PA- and anthocyanin-accumulating cells, by differentially integrating the signals issued from different regulators, in a spatio-temporal manner. Anthocyanins 78-89 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 45-48 23252373-3 2013 In two independent mutant alleles of cpk28, a reduction of stem elongation, accompanied by shorter leaf petioles and enhanced anthocyanin levels, is observed upon the transition to the generative phase. Anthocyanins 126-137 calcium-dependent protein kinase 28 Arabidopsis thaliana 37-42 23470220-0 2013 Anthocyanin-rich purple wheat prolongs the life span of Caenorhabditis elegans probably by activating the DAF-16/FOXO transcription factor. Anthocyanins 0-11 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 106-112 23450167-7 2013 Although ddb1a strongly enhances det1 phenotypes in both dark- and light-grown seedlings, ddb1b-2 weakly enhanced the det1 short hypocotyl phenotype in the dark, as well as enhancing anthocyanin levels and suppressing the det1 low chlorophyll phenotype in light-grown seedlings. Anthocyanins 183-194 damaged DNA binding protein 1B Arabidopsis thaliana 90-95 23450167-10 2013 In cop1 mutants, ddb1b-2 enhanced the cop1-4 short hypocotyl phenotype in dark and light, enhanced anthocyanin levels in cop1-1 in the light, but had no effect in adults. Anthocyanins 99-110 damaged DNA binding protein 1B Arabidopsis thaliana 17-22 22995388-0 2013 Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer"s disease. Anthocyanins 0-11 amyloid beta (A4) precursor protein Mus musculus 65-90 23344054-0 2013 Anthocyanins downregulate lipopolysaccharide-induced inflammatory responses in BV2 microglial cells by suppressing the NF-kappaB and Akt/MAPKs signaling pathways. Anthocyanins 0-12 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 119-128 23344054-0 2013 Anthocyanins downregulate lipopolysaccharide-induced inflammatory responses in BV2 microglial cells by suppressing the NF-kappaB and Akt/MAPKs signaling pathways. Anthocyanins 0-12 thymoma viral proto-oncogene 1 Mus musculus 133-136 23344054-4 2013 Our results showed that anthocyanins significantly inhibited LPS-induced pro-inflammatory mediators, such as nitric oxide (NO) and prostaglandin E(2), and pro-inflammatory cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, without significant cytotoxicity. Anthocyanins 24-36 tumor necrosis factor Mus musculus 192-225 23344054-4 2013 Our results showed that anthocyanins significantly inhibited LPS-induced pro-inflammatory mediators, such as nitric oxide (NO) and prostaglandin E(2), and pro-inflammatory cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, without significant cytotoxicity. Anthocyanins 24-36 interleukin 1 beta Mus musculus 230-252 23344054-5 2013 Anthocyanins also downregulated excessive expression of inducible NO synthase, cyclooxygenase-2, TNF-alpha, and IL-1beta in LPS-stimulated BV2 cells. Anthocyanins 0-12 nitric oxide synthase 2, inducible Mus musculus 56-77 23344054-5 2013 Anthocyanins also downregulated excessive expression of inducible NO synthase, cyclooxygenase-2, TNF-alpha, and IL-1beta in LPS-stimulated BV2 cells. Anthocyanins 0-12 prostaglandin-endoperoxide synthase 2 Mus musculus 79-95 22336903-8 2013 No effects were observed on inflammation or oxidative stress in vivo, except for von Willebrand factor, which was higher in the anthocyanin period (P=0.007). Anthocyanins 128-139 von Willebrand factor Homo sapiens 81-102 23220235-4 2013 Here, we used a pharmaceutical approach that Ca(2+) antagonists strongly interfered with sucrose uptake and anthocyanin accumulation by downregulating the expression of sucrose transporter 1 (SUC1) and transcriptional regulatory factors, such as PAP1. Anthocyanins 108-119 sucrose-proton symporter 2 Arabidopsis thaliana 169-190 23220235-4 2013 Here, we used a pharmaceutical approach that Ca(2+) antagonists strongly interfered with sucrose uptake and anthocyanin accumulation by downregulating the expression of sucrose transporter 1 (SUC1) and transcriptional regulatory factors, such as PAP1. Anthocyanins 108-119 sucrose-proton symporter 2 Arabidopsis thaliana 192-196 23220235-4 2013 Here, we used a pharmaceutical approach that Ca(2+) antagonists strongly interfered with sucrose uptake and anthocyanin accumulation by downregulating the expression of sucrose transporter 1 (SUC1) and transcriptional regulatory factors, such as PAP1. Anthocyanins 108-119 phosphatidic acid phosphatase 1 Arabidopsis thaliana 246-250 23344054-5 2013 Anthocyanins also downregulated excessive expression of inducible NO synthase, cyclooxygenase-2, TNF-alpha, and IL-1beta in LPS-stimulated BV2 cells. Anthocyanins 0-12 tumor necrosis factor Mus musculus 97-106 23344054-5 2013 Anthocyanins also downregulated excessive expression of inducible NO synthase, cyclooxygenase-2, TNF-alpha, and IL-1beta in LPS-stimulated BV2 cells. Anthocyanins 0-12 interleukin 1 beta Mus musculus 112-120 23344054-6 2013 Moreover, anthocyanins inhibited nuclear translocation of nuclear factor-kappa B (NF-kappaB) by reducing inhibitor of NF-kappaB alpha degradation as well as phosphorylating extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, and Akt. Anthocyanins 10-22 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 58-80 23344054-6 2013 Moreover, anthocyanins inhibited nuclear translocation of nuclear factor-kappa B (NF-kappaB) by reducing inhibitor of NF-kappaB alpha degradation as well as phosphorylating extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, and Akt. Anthocyanins 10-22 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 82-91 23344054-6 2013 Moreover, anthocyanins inhibited nuclear translocation of nuclear factor-kappa B (NF-kappaB) by reducing inhibitor of NF-kappaB alpha degradation as well as phosphorylating extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, and Akt. Anthocyanins 10-22 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 118-127 23344054-6 2013 Moreover, anthocyanins inhibited nuclear translocation of nuclear factor-kappa B (NF-kappaB) by reducing inhibitor of NF-kappaB alpha degradation as well as phosphorylating extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, and Akt. Anthocyanins 10-22 thymoma viral proto-oncogene 1 Mus musculus 237-282 22842532-3 2013 We tested the ability of various anthocyanins: to reduce cytochrome c, to support cytochrome c-induced mitochondrial respiration and to inhibit apoptosis induced by heart ischemia. Anthocyanins 33-45 cytochrome c, somatic Homo sapiens 57-69 22842532-3 2013 We tested the ability of various anthocyanins: to reduce cytochrome c, to support cytochrome c-induced mitochondrial respiration and to inhibit apoptosis induced by heart ischemia. Anthocyanins 33-45 cytochrome c, somatic Homo sapiens 82-94 22842532-4 2013 Anthocyanins such as delphinidin-3-glucoside (Dp3G) and cyanidin-3-glucoside (Cy3G) were able to reduce cytochrome c directly and rapidly, whereas pelargonidin-3-glucoside (Pg3G), malvinidin-3-glucoside (Mv3G) and peonidin-3-glucoside (Pn3G) had relatively low cytochrome c reducing activities. Anthocyanins 0-12 cytochrome c, somatic Homo sapiens 104-116 22842532-4 2013 Anthocyanins such as delphinidin-3-glucoside (Dp3G) and cyanidin-3-glucoside (Cy3G) were able to reduce cytochrome c directly and rapidly, whereas pelargonidin-3-glucoside (Pg3G), malvinidin-3-glucoside (Mv3G) and peonidin-3-glucoside (Pn3G) had relatively low cytochrome c reducing activities. Anthocyanins 0-12 cytochrome c, somatic Homo sapiens 261-273 22842532-7 2013 This suggests that the ability of anthocyanins to block caspase activation may be due to their ability to reduce cytosolic cytochrome c. Anthocyanins 34-46 cytochrome c, somatic Homo sapiens 123-135 23820171-0 2013 Black rice anthocyanidins prevent retinal photochemical damage via involvement of the AP-1/NF-kappaB/Caspase-1 pathway in Sprague-Dawley rats. Anthocyanins 11-25 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 86-90 23820171-0 2013 Black rice anthocyanidins prevent retinal photochemical damage via involvement of the AP-1/NF-kappaB/Caspase-1 pathway in Sprague-Dawley rats. Anthocyanins 11-25 caspase 1 Rattus norvegicus 101-110 23096157-2 2013 In apple (Malus x domestica), an R2R3 MYB transcription factor has been shown to control fruit flesh and foliage anthocyanin pigmentation (MYB10) and fruit skin color (MYB1). Anthocyanins 113-124 transcription factor MYB113-like Malus domestica 139-144 21546228-0 2013 The endothelial plasma membrane transporter bilitranslocase mediates rat aortic vasodilation induced by anthocyanins. Anthocyanins 104-116 ceruloplasmin Rattus norvegicus 44-59 21546228-3 2013 We therefore investigated the possible role of bilitranslocase (TC 2.A.65.1.1), an endothelial plasma membrane carrier that transports flavonoids, in the vasodilation activity induced by anthocyanins. Anthocyanins 187-199 ceruloplasmin Rattus norvegicus 47-62 21546228-5 2013 Pre-treatment of aortic rings with anti-sequence bilitranslocase antibodies targeting the carrier, decreased vasodilation induced by cyanidin 3-glucoside and bilberry anthocyanins. Anthocyanins 167-179 ceruloplasmin Rattus norvegicus 49-64 21546228-6 2013 CONCLUSION: Here we show for the first time that bilitranslocase mediates a critical step in vasodilation induced by anthocyanins. Anthocyanins 117-129 ceruloplasmin Rattus norvegicus 49-64 22681544-10 2013 Downstream transcription factor HY5 mediated explant photoprotection, perhaps by promoting anthocyanin accumulation, a pigment also induced by cytokinin. Anthocyanins 91-102 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 32-35 23096157-2 2013 In apple (Malus x domestica), an R2R3 MYB transcription factor has been shown to control fruit flesh and foliage anthocyanin pigmentation (MYB10) and fruit skin color (MYB1). Anthocyanins 113-124 transcription factor MYB86-like Malus domestica 139-143 23096157-7 2013 Functional characterization of MYB110a showed that it was able to up-regulate anthocyanin biosynthesis in tobacco (Nicotiana tabacum). Anthocyanins 78-89 transcription factor MYB114-like Malus domestica 31-38 23079990-1 2012 Recently, we found that the Arabidopsis TT19 protein, a glutathione S-transferase, has two functional domains that influence both anthocyanin and proanthocyanidin accumulation. Anthocyanins 130-141 glutathione S-transferase phi 12 Arabidopsis thaliana 40-44 23079990-4 2012 Transformation of the Arabidopsis loss-of-function tt19-1 mutant with CMGSTF12 cDNA complemented accumulation of anthocyanin in vegetative tissues and resulted in the wild-type level of proanthocyanidin (both extractable and unextractable) in seeds. Anthocyanins 113-124 glutathione S-transferase phi 12 Arabidopsis thaliana 51-55 23044227-10 2012 Furthermore, the treatment with anthocyanins prevents the decrease in 5"-nucleotidase activity and the increase in adenosine deaminase activity induced by SCO in HC. Anthocyanins 32-44 5' nucleotidase, ecto Rattus norvegicus 70-85 23044227-10 2012 Furthermore, the treatment with anthocyanins prevents the decrease in 5"-nucleotidase activity and the increase in adenosine deaminase activity induced by SCO in HC. Anthocyanins 32-44 adenosine deaminase Rattus norvegicus 115-134 22915577-4 2012 METHODS: To induce anthocyanin production and increase isoflavonoid precursors in tobacco, the tomato R2R3 MYB transcription factor ANT1 was expressed in tobacco (Nt-ANT1 plants). Anthocyanins 19-30 anthocyanin 1 Solanum lycopersicum 132-136 22873220-0 2012 Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma. Anthocyanins 14-26 NFE2 like bZIP transcription factor 2 Rattus norvegicus 61-65 22873220-9 2012 The results of our study provide substantial evidence that black currant bioactive anthocyanins exert chemopreventive actions against DENA-inflicted hepatocarcinogenesis by attenuating oxidative stress through activation of Nrf2 signaling pathway. Anthocyanins 83-95 NFE2 like bZIP transcription factor 2 Rattus norvegicus 224-228 22569920-6 2012 qRT-PCR analysis showed that the responses of three MYB-related genes (VlMYBA1-3, VlMYBA1-2, and VlMYBA2) to temperature and light differed greatly even though the products of all three genes had the ability to regulate anthocyanin biosynthesis pathway genes. Anthocyanins 220-231 MYB proto-oncogene, transcription factor Homo sapiens 52-55 22519753-0 2012 The bHLH transcription factor MdbHLH3 promotes anthocyanin accumulation and fruit colouration in response to low temperature in apples. Anthocyanins 47-58 basic helix-loop-helix protein A Malus domestica 4-29 23129091-3 2012 The cytotoxicity observed in the anthocyanidins-treated cells was well correlated with the inhibitory effects of anthocyanidins on c-Jun-dependent transcriptional activity. Anthocyanins 33-47 jun proto-oncogene Mus musculus 131-136 23129091-3 2012 The cytotoxicity observed in the anthocyanidins-treated cells was well correlated with the inhibitory effects of anthocyanidins on c-Jun-dependent transcriptional activity. Anthocyanins 113-127 jun proto-oncogene Mus musculus 131-136 23017908-6 2012 Promoter fragments corresponding to known genes were amplified from various genotypes and used to drive the VvMybA1 gene of "Merlot" for anthocyanin production in non-pigmented somatic embryo (SE) explants to infer transcriptional activity. Anthocyanins 137-148 MYBA1 Vitis vinifera 108-115 22855128-0 2012 cry1 and GPA1 signaling genetically interact in hook opening and anthocyanin synthesis in Arabidopsis. Anthocyanins 65-76 cryptochrome 1 Arabidopsis thaliana 0-4 22855128-0 2012 cry1 and GPA1 signaling genetically interact in hook opening and anthocyanin synthesis in Arabidopsis. Anthocyanins 65-76 G protein alpha subunit 1 Arabidopsis thaliana 9-13 22855128-2 2012 Both cry1 and gpa1 also showed reduced accumulation of anthocyanin under blue light. Anthocyanins 55-66 cryptochrome 1 Arabidopsis thaliana 5-9 22855128-2 2012 Both cry1 and gpa1 also showed reduced accumulation of anthocyanin under blue light. Anthocyanins 55-66 G protein alpha subunit 1 Arabidopsis thaliana 14-18 22872589-3 2012 However, the molecular mechanisms by which anthocyanins (delphinidin and cyanin) and quercetin regulate the renin-angiotensin system are not completely understood. Anthocyanins 43-55 renin Homo sapiens 108-113 22644767-0 2012 Characterization of the regulatory network of BoMYB2 in controlling anthocyanin biosynthesis in purple cauliflower. Anthocyanins 68-79 transcription factor MYB114-like Brassica oleracea 46-52 21533841-2 2012 One siRNA, TAS4-siRNA81(-), targets a set of MYB transcription factors including PAP1, PAP2, and MYB113 which regulate the anthocyanin biosynthesis pathway. Anthocyanins 123-134 AT3G25795 Arabidopsis thaliana 11-15 22644767-2 2012 botrytis) Graffiti represents a unique mutant in conferring ectopic anthocyanin biosynthesis, which is caused by the tissue-specific activation of BoMYB2, an ortholog of Arabidopsis PAP2 or MYB113. Anthocyanins 68-79 transcription factor MYB114-like Brassica oleracea 147-153 22644767-2 2012 botrytis) Graffiti represents a unique mutant in conferring ectopic anthocyanin biosynthesis, which is caused by the tissue-specific activation of BoMYB2, an ortholog of Arabidopsis PAP2 or MYB113. Anthocyanins 68-79 Purple acid phosphatases superfamily protein Arabidopsis thaliana 182-186 22644767-2 2012 botrytis) Graffiti represents a unique mutant in conferring ectopic anthocyanin biosynthesis, which is caused by the tissue-specific activation of BoMYB2, an ortholog of Arabidopsis PAP2 or MYB113. Anthocyanins 68-79 myb domain protein 113 Arabidopsis thaliana 190-196 22644767-6 2012 Examination of the BoMYB2 transgenic lines in Arabidopsis bHLH mutant backgrounds demonstrated that TT8, EGL3, and GL3 were all involved in the BoMYB2-mediated anthocyanin biosynthesis. Anthocyanins 176-187 transcription factor MYB114-like Brassica oleracea 19-25 22644767-6 2012 Examination of the BoMYB2 transgenic lines in Arabidopsis bHLH mutant backgrounds demonstrated that TT8, EGL3, and GL3 were all involved in the BoMYB2-mediated anthocyanin biosynthesis. Anthocyanins 176-187 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 116-119 22644767-6 2012 Examination of the BoMYB2 transgenic lines in Arabidopsis bHLH mutant backgrounds demonstrated that TT8, EGL3, and GL3 were all involved in the BoMYB2-mediated anthocyanin biosynthesis. Anthocyanins 176-187 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 121-125 22644767-6 2012 Examination of the BoMYB2 transgenic lines in Arabidopsis bHLH mutant backgrounds demonstrated that TT8, EGL3, and GL3 were all involved in the BoMYB2-mediated anthocyanin biosynthesis. Anthocyanins 176-187 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 122-125 22644767-6 2012 Examination of the BoMYB2 transgenic lines in Arabidopsis bHLH mutant backgrounds demonstrated that TT8, EGL3, and GL3 were all involved in the BoMYB2-mediated anthocyanin biosynthesis. Anthocyanins 176-187 transcription factor MYB114-like Brassica oleracea 160-166 22644767-7 2012 Expression of BoMYB2 in Arabidopsis caused up-regulation of AtTT8 and AtEGL3 as well as a subset of anthocyanin structural genes encoding flavonoid 3"-hydroxylase, dihydroflavonol 4-reductase, and leucoanthocyanidin dioxygenase. Anthocyanins 100-111 transcription factor MYB114-like Brassica oleracea 14-20 22644767-9 2012 BoMYB2 together with various BobHLHs specifically regulated the late anthocyanin biosynthetic pathway genes for anthocyanin biosynthesis. Anthocyanins 69-80 transcription factor MYB114-like Brassica oleracea 0-6 22644767-9 2012 BoMYB2 together with various BobHLHs specifically regulated the late anthocyanin biosynthetic pathway genes for anthocyanin biosynthesis. Anthocyanins 112-123 transcription factor MYB114-like Brassica oleracea 0-6 21533841-2 2012 One siRNA, TAS4-siRNA81(-), targets a set of MYB transcription factors including PAP1, PAP2, and MYB113 which regulate the anthocyanin biosynthesis pathway. Anthocyanins 123-134 phosphatidic acid phosphatase 1 Arabidopsis thaliana 81-85 22669605-0 2012 Regulation of anthocyanin biosynthesis by nitrogen in TTG1-GL3/TT8-PAP1-programmed red cells of Arabidopsis thaliana. Anthocyanins 14-25 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 54-58 21533841-2 2012 One siRNA, TAS4-siRNA81(-), targets a set of MYB transcription factors including PAP1, PAP2, and MYB113 which regulate the anthocyanin biosynthesis pathway. Anthocyanins 123-134 Purple acid phosphatases superfamily protein Arabidopsis thaliana 87-91 22669605-0 2012 Regulation of anthocyanin biosynthesis by nitrogen in TTG1-GL3/TT8-PAP1-programmed red cells of Arabidopsis thaliana. Anthocyanins 14-25 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 59-62 22669605-0 2012 Regulation of anthocyanin biosynthesis by nitrogen in TTG1-GL3/TT8-PAP1-programmed red cells of Arabidopsis thaliana. Anthocyanins 14-25 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 63-66 21533841-2 2012 One siRNA, TAS4-siRNA81(-), targets a set of MYB transcription factors including PAP1, PAP2, and MYB113 which regulate the anthocyanin biosynthesis pathway. Anthocyanins 123-134 myb domain protein 113 Arabidopsis thaliana 97-103 22669605-0 2012 Regulation of anthocyanin biosynthesis by nitrogen in TTG1-GL3/TT8-PAP1-programmed red cells of Arabidopsis thaliana. Anthocyanins 14-25 phosphatidic acid phosphatase 1 Arabidopsis thaliana 67-71 21533841-6 2012 PAP1 is under regulation by TAS4, demonstrated by the accumulation of PAP1 transcripts and anthocyanin in ta-siRNA biogenesis pathway mutants. Anthocyanins 91-102 phosphatidic acid phosphatase 1 Arabidopsis thaliana 0-4 22669605-2 2012 In this investigation, we report the nitrogen regulation of anthocyanin biosynthesis activated by TTG1-GL3/TT8-PAP1 in red pap1-D cells. Anthocyanins 60-71 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 98-102 21533841-6 2012 PAP1 is under regulation by TAS4, demonstrated by the accumulation of PAP1 transcripts and anthocyanin in ta-siRNA biogenesis pathway mutants. Anthocyanins 91-102 AT3G25795 Arabidopsis thaliana 28-32 22669605-2 2012 In this investigation, we report the nitrogen regulation of anthocyanin biosynthesis activated by TTG1-GL3/TT8-PAP1 in red pap1-D cells. Anthocyanins 60-71 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 103-106 22669605-2 2012 In this investigation, we report the nitrogen regulation of anthocyanin biosynthesis activated by TTG1-GL3/TT8-PAP1 in red pap1-D cells. Anthocyanins 60-71 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 107-110 21533841-12 2012 Taken together, our results suggest that regulation of anthocyanin biosynthesis by TAS4 and miR828 in higher plants is evolutionarily significant and consistent with the evolution of TAS4 since the dicot-monocot divergence. Anthocyanins 55-66 AT3G25795 Arabidopsis thaliana 83-87 22669605-2 2012 In this investigation, we report the nitrogen regulation of anthocyanin biosynthesis activated by TTG1-GL3/TT8-PAP1 in red pap1-D cells. Anthocyanins 60-71 phosphatidic acid phosphatase 1 Arabidopsis thaliana 111-115 22669605-2 2012 In this investigation, we report the nitrogen regulation of anthocyanin biosynthesis activated by TTG1-GL3/TT8-PAP1 in red pap1-D cells. Anthocyanins 60-71 phosphatidic acid phosphatase 1 Arabidopsis thaliana 123-127 22669605-5 2012 An expression analysis of the main regulatory and pathway genes showed that at conditions of higher concentrations of ammonium and total nitrogen, the expression levels of PAP1 and TT8 decreased, but the expression levels of LBD37, 38 and 39, three negative regulators of anthocyanin biosynthesis, increased. Anthocyanins 272-283 LOB domain-containing protein 37 Arabidopsis thaliana 225-230 22669605-8 2012 These results show that nitrogen regulation of anthocyanin biosynthesis in red cells undergoes a mechanism by which nitrogen controls the expression of genes encoding both main components of the TTG1-GL3/TT8-PAP1 complex and negative regulators. Anthocyanins 47-58 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 195-199 22669605-8 2012 These results show that nitrogen regulation of anthocyanin biosynthesis in red cells undergoes a mechanism by which nitrogen controls the expression of genes encoding both main components of the TTG1-GL3/TT8-PAP1 complex and negative regulators. Anthocyanins 47-58 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 200-203 22669605-8 2012 These results show that nitrogen regulation of anthocyanin biosynthesis in red cells undergoes a mechanism by which nitrogen controls the expression of genes encoding both main components of the TTG1-GL3/TT8-PAP1 complex and negative regulators. Anthocyanins 47-58 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 204-207 21533841-12 2012 Taken together, our results suggest that regulation of anthocyanin biosynthesis by TAS4 and miR828 in higher plants is evolutionarily significant and consistent with the evolution of TAS4 since the dicot-monocot divergence. Anthocyanins 55-66 MIR828 Arabidopsis thaliana 92-98 22669605-8 2012 These results show that nitrogen regulation of anthocyanin biosynthesis in red cells undergoes a mechanism by which nitrogen controls the expression of genes encoding both main components of the TTG1-GL3/TT8-PAP1 complex and negative regulators. Anthocyanins 47-58 phosphatidic acid phosphatase 1 Arabidopsis thaliana 208-212 21533841-12 2012 Taken together, our results suggest that regulation of anthocyanin biosynthesis by TAS4 and miR828 in higher plants is evolutionarily significant and consistent with the evolution of TAS4 since the dicot-monocot divergence. Anthocyanins 55-66 AT3G25795 Arabidopsis thaliana 183-187 22778424-5 2012 In this configuration, the R-RIF1 complex is recruited to the promoters of a subset of anthocyanin biosynthetic genes, such as A1, through the interaction with its MYB partner C1. Anthocyanins 87-98 r-interacting factor 1 Zea mays 29-33 22083247-0 2012 Coloring genetically modified soybean grains with anthocyanins by suppression of the proanthocyanidin genes ANR1 and ANR2. Anthocyanins 50-62 anthocyanidin reductase 1 Glycine max 108-112 22083247-5 2012 The upregulations of anthocyanin isogenes (DFR1 and GST26) and the anthocyanin/flavonol-3-O-glycosyltransferase (UGT78K2) were identified by quantitative RT-PCR to be endogenous feedback and feedforward responses to overaccumulation of upstream flavonoid intermediates resulting from ANR1 and ANR2 suppressions. Anthocyanins 21-32 vestitone reductase Glycine max 43-47 22083247-5 2012 The upregulations of anthocyanin isogenes (DFR1 and GST26) and the anthocyanin/flavonol-3-O-glycosyltransferase (UGT78K2) were identified by quantitative RT-PCR to be endogenous feedback and feedforward responses to overaccumulation of upstream flavonoid intermediates resulting from ANR1 and ANR2 suppressions. Anthocyanins 21-32 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 113-120 22083247-5 2012 The upregulations of anthocyanin isogenes (DFR1 and GST26) and the anthocyanin/flavonol-3-O-glycosyltransferase (UGT78K2) were identified by quantitative RT-PCR to be endogenous feedback and feedforward responses to overaccumulation of upstream flavonoid intermediates resulting from ANR1 and ANR2 suppressions. Anthocyanins 21-32 anthocyanidin reductase 1 Glycine max 284-288 22111523-3 2012 TIM-1 revealed that most anthocyanins were bioaccessible between the second and third hours after intake. Anthocyanins 25-37 Rho guanine nucleotide exchange factor 5 Homo sapiens 0-5 22699753-4 2012 Genetic analysis showed that cytokinin signaling modulates sugar-induced anthocyanin biosynthesis through a two-component signaling cascade involving the type-B response regulators ARR1, ARR10 and ARR12 in a redundant manner. Anthocyanins 73-84 response regulator 1 Arabidopsis thaliana 181-185 22699753-4 2012 Genetic analysis showed that cytokinin signaling modulates sugar-induced anthocyanin biosynthesis through a two-component signaling cascade involving the type-B response regulators ARR1, ARR10 and ARR12 in a redundant manner. Anthocyanins 73-84 response regulator 10 Arabidopsis thaliana 187-192 22699753-4 2012 Genetic analysis showed that cytokinin signaling modulates sugar-induced anthocyanin biosynthesis through a two-component signaling cascade involving the type-B response regulators ARR1, ARR10 and ARR12 in a redundant manner. Anthocyanins 73-84 response regulator 12 Arabidopsis thaliana 197-202 22703874-4 2012 Results showed that LPS-induced adipose stem cell secretion of IL-6 reduced with the addition of tart cherry extract, a mixture of tart cherry anthocyanins, and pure tart cherry cyanidin-3-O-glucoside (C3G) in a dose-dependent manner. Anthocyanins 143-155 interleukin 6 Homo sapiens 63-67 22654889-5 2012 ZmFLSs expression was analyzed in different maize tissues, and by combining electrophoretic mobility shift assays and transient expression experiments, we show that both genes are direct targets of anthocyanin (C1/PL1 + R/B) and 3-deoxy flavonoid (P1) transcriptional regulators. Anthocyanins 198-209 anthocyanin regulatory C1 protein Zea mays 211-223 22575822-0 2012 Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids. Anthocyanins 41-53 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 74-78 22575822-0 2012 Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids. Anthocyanins 41-53 mitogen-activated protein kinase 8 Homo sapiens 79-82 22575822-0 2012 Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids. Anthocyanins 41-53 mitogen-activated protein kinase 14 Homo sapiens 83-86 22575822-4 2012 KEY FINDINGS: Pretreatment with anthocyanins reduced the cytotoxicity of H(2)O(2) on SK-N-SH cells, dose-dependently reduced the intracellular ROS level and inactivated apoptosis signal-regulating kinase (ASK1, Thr845), p38, and c-Jun N-terminal kinase (JNK) proteins. Anthocyanins 32-44 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 205-209 22575822-4 2012 KEY FINDINGS: Pretreatment with anthocyanins reduced the cytotoxicity of H(2)O(2) on SK-N-SH cells, dose-dependently reduced the intracellular ROS level and inactivated apoptosis signal-regulating kinase (ASK1, Thr845), p38, and c-Jun N-terminal kinase (JNK) proteins. Anthocyanins 32-44 mitogen-activated protein kinase 14 Homo sapiens 220-223 22575822-4 2012 KEY FINDINGS: Pretreatment with anthocyanins reduced the cytotoxicity of H(2)O(2) on SK-N-SH cells, dose-dependently reduced the intracellular ROS level and inactivated apoptosis signal-regulating kinase (ASK1, Thr845), p38, and c-Jun N-terminal kinase (JNK) proteins. Anthocyanins 32-44 mitogen-activated protein kinase 8 Homo sapiens 229-252 22575822-4 2012 KEY FINDINGS: Pretreatment with anthocyanins reduced the cytotoxicity of H(2)O(2) on SK-N-SH cells, dose-dependently reduced the intracellular ROS level and inactivated apoptosis signal-regulating kinase (ASK1, Thr845), p38, and c-Jun N-terminal kinase (JNK) proteins. Anthocyanins 32-44 mitogen-activated protein kinase 8 Homo sapiens 254-257 22575822-5 2012 The HO-1 and Neu1 mRNA levels were increased by H(2)O(2) (25 muM) and further elevated by the pretreatment with anthocyanins. Anthocyanins 112-124 heme oxygenase 1, chloroplastic Glycine max 4-8 22575822-7 2012 These results suggest that Cheongja 3 black soybean seed coat anthocyanins have brain neuroprotective effects against oxidative stress (H(2)O(2)) by inhibiting the activation of ASK1-JNK/p38 pathways, scavenging ROS, stimulating the expression of HO-1 and, more interestingly, recruiting cellular free sialic acids through up-regulation of Neu1 sialidase gene expression. Anthocyanins 62-74 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 178-182 22575822-7 2012 These results suggest that Cheongja 3 black soybean seed coat anthocyanins have brain neuroprotective effects against oxidative stress (H(2)O(2)) by inhibiting the activation of ASK1-JNK/p38 pathways, scavenging ROS, stimulating the expression of HO-1 and, more interestingly, recruiting cellular free sialic acids through up-regulation of Neu1 sialidase gene expression. Anthocyanins 62-74 mitogen-activated protein kinase 8 Homo sapiens 183-186 22575822-7 2012 These results suggest that Cheongja 3 black soybean seed coat anthocyanins have brain neuroprotective effects against oxidative stress (H(2)O(2)) by inhibiting the activation of ASK1-JNK/p38 pathways, scavenging ROS, stimulating the expression of HO-1 and, more interestingly, recruiting cellular free sialic acids through up-regulation of Neu1 sialidase gene expression. Anthocyanins 62-74 mitogen-activated protein kinase 14 Homo sapiens 187-190 22575822-7 2012 These results suggest that Cheongja 3 black soybean seed coat anthocyanins have brain neuroprotective effects against oxidative stress (H(2)O(2)) by inhibiting the activation of ASK1-JNK/p38 pathways, scavenging ROS, stimulating the expression of HO-1 and, more interestingly, recruiting cellular free sialic acids through up-regulation of Neu1 sialidase gene expression. Anthocyanins 62-74 heme oxygenase 1, chloroplastic Glycine max 247-251 22694328-6 2012 The feeding of the anthocyanin-rich corn silage led to a reduction in aspartate aminotransferase (AST) activity and an increase in superoxide dismutase (SOD) activity in the plasma. Anthocyanins 19-30 aspartate aminotransferase Zea mays 70-96 22694328-6 2012 The feeding of the anthocyanin-rich corn silage led to a reduction in aspartate aminotransferase (AST) activity and an increase in superoxide dismutase (SOD) activity in the plasma. Anthocyanins 19-30 aspartate aminotransferase Zea mays 98-101 22694328-6 2012 The feeding of the anthocyanin-rich corn silage led to a reduction in aspartate aminotransferase (AST) activity and an increase in superoxide dismutase (SOD) activity in the plasma. Anthocyanins 19-30 superoxide dismutase Zea mays 131-151 22694328-6 2012 The feeding of the anthocyanin-rich corn silage led to a reduction in aspartate aminotransferase (AST) activity and an increase in superoxide dismutase (SOD) activity in the plasma. Anthocyanins 19-30 superoxide dismutase Zea mays 153-156 22694328-7 2012 These data suggest that the anthocyanin-rich corn has a lowering effect on AST activity with concomitant enhancement of SOD activity in lactating dairy cows. Anthocyanins 28-39 aspartate aminotransferase Zea mays 75-78 22694328-7 2012 These data suggest that the anthocyanin-rich corn has a lowering effect on AST activity with concomitant enhancement of SOD activity in lactating dairy cows. Anthocyanins 28-39 superoxide dismutase Zea mays 120-123 22144032-6 2012 Anthocyanin contents were positively correlated with PAL, POD, A*, MDA and O2( -) values and inversely correlated with L* and B* values. Anthocyanins 0-11 leucine rich repeat, Ig-like and transmembrane domains 1 Homo sapiens 53-56 22439618-6 2012 All the anthocyanins tested enhanced significantly the growth of Bifidobacterium spp. Anthocyanins 8-20 histocompatibility minor 13 Homo sapiens 81-84 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Anthocyanins 284-295 regulatory particle triple-A ATPase 5A Arabidopsis thaliana 111-116 22251797-0 2012 Molecular characterization of an anthocyanin-related glutathione S-transferase gene in cyclamen. Anthocyanins 33-44 glutathione S-transferase tau 5 Arabidopsis thaliana 53-78 22251797-2 2012 Previous studies in model and ornamental plants indicate a member of the glutathione S-transferase (GST) gene family is involved in vacuolar accumulation of anthocyanins. Anthocyanins 157-169 glutathione S-transferase tau 5 Arabidopsis thaliana 73-98 22251797-2 2012 Previous studies in model and ornamental plants indicate a member of the glutathione S-transferase (GST) gene family is involved in vacuolar accumulation of anthocyanins. Anthocyanins 157-169 glutathione S-transferase tau 5 Arabidopsis thaliana 100-103 22251797-3 2012 In order to identify the anthocyanin-related GST in cyclamen, degenerate PCR was performed using total RNA from immature young petals. Anthocyanins 25-36 glutathione S-transferase tau 5 Arabidopsis thaliana 45-48 22251797-5 2012 Phylogenetic analysis indicated that CkmGST3 was closely related to PhAN9, an anthocyanin-related GST of petunia, and this clade was clustered with other known anthocyanin-related GSTs. Anthocyanins 78-89 glutathione S-transferase tau 5 Arabidopsis thaliana 40-43 22251797-5 2012 Phylogenetic analysis indicated that CkmGST3 was closely related to PhAN9, an anthocyanin-related GST of petunia, and this clade was clustered with other known anthocyanin-related GSTs. Anthocyanins 160-171 glutathione S-transferase tau 5 Arabidopsis thaliana 40-43 22251797-8 2012 Molecular complementation of Arabidopsis tt19, a knockout mutant of an anthocyanin-related GST gene, demonstrated that CkmGST3 could complement the anthocyanin-less phenotype of tt19. Anthocyanins 71-82 glutathione S-transferase tau 5 Arabidopsis thaliana 91-94 22251797-8 2012 Molecular complementation of Arabidopsis tt19, a knockout mutant of an anthocyanin-related GST gene, demonstrated that CkmGST3 could complement the anthocyanin-less phenotype of tt19. Anthocyanins 148-159 glutathione S-transferase tau 5 Arabidopsis thaliana 91-94 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Anthocyanins 284-295 Tubulin/FtsZ family protein Arabidopsis thaliana 146-161 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Anthocyanins 284-295 Tubulin/FtsZ family protein Arabidopsis thaliana 163-167 22238451-0 2012 Introduction of apple ANR genes into tobacco inhibits expression of both CHI and DFR genes in flowers, leading to loss of anthocyanin. Anthocyanins 122-133 anthocyanidin reductase Malus domestica 22-25 22238451-11 2012 The inhibition of anthocyanin synthesis in tobacco transgenic flowers overexpressing MdANR genes is probably attributed to down-regulation of CHALCONE ISOMERASE (CHI) and DIHYDROFLAVONOL-4-REDUCTASE (DFR) genes involved in the anthocyanin pathway. Anthocyanins 18-29 chalcone--flavanone isomerase Nicotiana tabacum 142-160 22238451-11 2012 The inhibition of anthocyanin synthesis in tobacco transgenic flowers overexpressing MdANR genes is probably attributed to down-regulation of CHALCONE ISOMERASE (CHI) and DIHYDROFLAVONOL-4-REDUCTASE (DFR) genes involved in the anthocyanin pathway. Anthocyanins 18-29 dihydroflavonol-4-reductase Nicotiana tabacum 171-198 22238451-11 2012 The inhibition of anthocyanin synthesis in tobacco transgenic flowers overexpressing MdANR genes is probably attributed to down-regulation of CHALCONE ISOMERASE (CHI) and DIHYDROFLAVONOL-4-REDUCTASE (DFR) genes involved in the anthocyanin pathway. Anthocyanins 18-29 dihydroflavonol-4-reductase Nicotiana tabacum 200-203 22523204-5 2012 Moreover, opr7 opr8 exhibited delayed leaf senescence accompanied by reduced ethylene and abscisic acid levels and lack of anthocyanin pigmentation of brace roots. Anthocyanins 123-134 12-oxophytodienoate reductase7 Zea mays 10-19 22218934-0 2012 Potential anti-inflammatory, anti-adhesive, anti/estrogenic, and angiotensin-converting enzyme inhibitory activities of anthocyanins and their gut metabolites. Anthocyanins 120-132 angiotensin I converting enzyme Homo sapiens 65-94 22218934-3 2012 The objective of this study was to evaluate the effects of anthocyanins and their breakdown metabolites, protocatechuic, syringic, gallic, and vanillic acids, on different parameters involved in atherosclerosis, including inflammation, cell adhesion, chemotaxis, endothelial function, estrogenic/anti-estrogenic activity, and angiotensin-converting enzyme (ACE) inhibitory activity. Anthocyanins 59-71 angiotensin I converting enzyme Homo sapiens 326-355 22218934-3 2012 The objective of this study was to evaluate the effects of anthocyanins and their breakdown metabolites, protocatechuic, syringic, gallic, and vanillic acids, on different parameters involved in atherosclerosis, including inflammation, cell adhesion, chemotaxis, endothelial function, estrogenic/anti-estrogenic activity, and angiotensin-converting enzyme (ACE) inhibitory activity. Anthocyanins 59-71 angiotensin I converting enzyme Homo sapiens 357-360 22218934-6 2012 All anthocyanins showed an ACE-inhibitory activity. Anthocyanins 4-16 angiotensin I converting enzyme Homo sapiens 27-30 22218934-9 2012 However, the concentrations of anthocyanins and their metabolites, as used in the present cell culture and in vitro assays mediating anti-inflammatory, anti-adhesive, anti-estrogenic, and angiotensin-converting enzyme inhibitory activities, were often manifold higher than those physiologically achievable. Anthocyanins 31-43 angiotensin I converting enzyme Homo sapiens 188-217 21543211-2 2012 Here, we hypothesized that cyanidin 3-glucoside (C3G), a typical anthocyanin reported to possess potent anti-inflammatory properties, would ameliorate obesity-associated inflammation and metabolic disorders, such as insulin resistance and hepatic steatosis in mouse models of diabesity. Anthocyanins 65-76 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 27-52 22429339-8 2012 Anthocyanins were more abundant in Alaskan samples and correlated with flavonoid genes including DFR (r = 0.91), UFGT (r = 0.94) and F3H (r = 0.77). Anthocyanins 0-12 dihydroflavonol-4-reductase Solanum tuberosum 97-100 24116296-8 2012 Also, augmented enzyme (SOD and CAT) activities were observed in UVA-irradiated cells when treated with anthocyanin. Anthocyanins 104-115 catalase Homo sapiens 32-35 22464474-0 2012 The upregulation of NtAN2 expression at low temperature is required for anthocyanin accumulation in juvenile leaves of Lc-transgenic tobacco (Nicotiana tabacum L.). Anthocyanins 72-83 transcription factor MYB114-like Nicotiana tabacum 20-25 22464474-9 2012 Based on our findings and previous reports, we postulated that Lc interacted with NtAN2 induced by low-temperature stress and consequently stimulated anthocyanin biosynthesis in juvenile leaves of Lc-transgenic tobacco lines. Anthocyanins 150-161 transcription factor MYB114-like Nicotiana tabacum 82-87 22181073-1 2012 Chinese bayberry fruit is a rich source of anthocyanins, especially cyanidin-3-glucoside (C3G). Anthocyanins 43-55 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 68-93 22201047-0 2012 Arabidopsis TT19 functions as a carrier to transport anthocyanin from the cytosol to tonoplasts. Anthocyanins 53-64 glutathione S-transferase phi 12 Arabidopsis thaliana 12-16 22201047-3 2012 Here, we provide evidence supporting that Transparent Testa 19 (TT19), a glutathione S-transferase (GST), functions as a carrier to transport cyanidin and/or anthocyanins to the tonoplast. Anthocyanins 158-170 glutathione S-transferase phi 12 Arabidopsis thaliana 54-62 22201047-3 2012 Here, we provide evidence supporting that Transparent Testa 19 (TT19), a glutathione S-transferase (GST), functions as a carrier to transport cyanidin and/or anthocyanins to the tonoplast. Anthocyanins 158-170 glutathione S-transferase phi 12 Arabidopsis thaliana 64-68 22201047-3 2012 Here, we provide evidence supporting that Transparent Testa 19 (TT19), a glutathione S-transferase (GST), functions as a carrier to transport cyanidin and/or anthocyanins to the tonoplast. Anthocyanins 158-170 glutathione S-transferase F11 Arabidopsis thaliana 73-98 22201047-3 2012 Here, we provide evidence supporting that Transparent Testa 19 (TT19), a glutathione S-transferase (GST), functions as a carrier to transport cyanidin and/or anthocyanins to the tonoplast. Anthocyanins 158-170 glutathione S-transferase F11 Arabidopsis thaliana 100-103 22201047-4 2012 We identified a novel tt19 mutant (tt19-7), which barely accumulates anthocyanins but produces a 36% higher level of flavonol than the wild-type (WT), from ethyl methanesulfonate mutagenized seeds. Anthocyanins 69-81 glutathione S-transferase phi 12 Arabidopsis thaliana 22-26 22201047-4 2012 We identified a novel tt19 mutant (tt19-7), which barely accumulates anthocyanins but produces a 36% higher level of flavonol than the wild-type (WT), from ethyl methanesulfonate mutagenized seeds. Anthocyanins 69-81 glutathione S-transferase phi 12 Arabidopsis thaliana 35-39 22201047-5 2012 Expressing TT19-fused green fluorescence protein (GFP) in tt19-7 rescues the mutant phenotype in defective anthocyanin biosynthesis, indicating that TT19-GFP is functional. Anthocyanins 107-118 glutathione S-transferase phi 12 Arabidopsis thaliana 11-15 22201047-5 2012 Expressing TT19-fused green fluorescence protein (GFP) in tt19-7 rescues the mutant phenotype in defective anthocyanin biosynthesis, indicating that TT19-GFP is functional. Anthocyanins 107-118 glutathione S-transferase phi 12 Arabidopsis thaliana 58-62 22201047-5 2012 Expressing TT19-fused green fluorescence protein (GFP) in tt19-7 rescues the mutant phenotype in defective anthocyanin biosynthesis, indicating that TT19-GFP is functional. Anthocyanins 107-118 glutathione S-transferase phi 12 Arabidopsis thaliana 149-153 22201047-11 2012 Taken together, our data reveal molecular mechanism underlying TT19-mediated anthocyanin transportation. Anthocyanins 77-88 glutathione S-transferase phi 12 Arabidopsis thaliana 63-67 22167189-5 2012 We also show that the dominant ref4-3 mutant protein interferes with the ability of the PAP1/MYB75 transcription factor to induce the expression of PAL1 and drive anthocyanin accumulation. Anthocyanins 163-174 reduced epidermal fluorescence 4 Arabidopsis thaliana 31-35 22167189-5 2012 We also show that the dominant ref4-3 mutant protein interferes with the ability of the PAP1/MYB75 transcription factor to induce the expression of PAL1 and drive anthocyanin accumulation. Anthocyanins 163-174 phosphatidic acid phosphatase 1 Arabidopsis thaliana 88-92 22167189-5 2012 We also show that the dominant ref4-3 mutant protein interferes with the ability of the PAP1/MYB75 transcription factor to induce the expression of PAL1 and drive anthocyanin accumulation. Anthocyanins 163-174 production of anthocyanin pigment 1 Arabidopsis thaliana 93-98 21631536-4 2012 The ascorbate-deficient mutants vtc1, vtc2 and vtc3 accumulated less anthocyanin than wild-type (WT) during HL acclimation. Anthocyanins 69-80 GDP-L-galactose phosphorylase 1 Arabidopsis thaliana 38-42 22178976-3 2012 Recent studies have also shown that anthocyanins have estrogenic activity and can enhance estrogen receptor-alpha expression. Anthocyanins 36-48 estrogen receptor 1 (alpha) Mus musculus 90-113 21631536-8 2012 RT-PCR analysis showed that vtc1 and vtc2 were impaired in HL induction of transcripts of anthocyanin biosynthesis enzymes, and the transcription factors PAP1, GL3 and EGL3 that activate the pathway. Anthocyanins 90-101 Glucose-1-phosphate adenylyltransferase family protein Arabidopsis thaliana 28-32 21631536-8 2012 RT-PCR analysis showed that vtc1 and vtc2 were impaired in HL induction of transcripts of anthocyanin biosynthesis enzymes, and the transcription factors PAP1, GL3 and EGL3 that activate the pathway. Anthocyanins 90-101 GDP-L-galactose phosphorylase 1 Arabidopsis thaliana 37-41 21633982-6 2012 These findings indicate that PRE and anthocyanidins suppress VEGF-induced angiogenesis by inhibiting proliferation and migration and suggest that the inhibition of phosphorylated-ERK and -p38 may be involved in the underlying mechanism. Anthocyanins 37-51 vascular endothelial growth factor A Homo sapiens 61-65 22493802-6 2012 In addition, the effects of anthocyanidin on phosphorylation of NF-kappaB, p38MAPK and Akt were observed by Western blotting. Anthocyanins 28-41 AKT serine/threonine kinase 1 Rattus norvegicus 87-90 21947299-5 2012 Two genes encoding homologous R2R3 MYB transcription factors, termed ANT1 and AN2, were previously genetically implicated in anthocyanin accumulation in tomato fruit peels of the ANTHOCYANIN FRUIT (AFT) genotype originating from S. chilense. Anthocyanins 125-136 anthocyanin 1 Solanum lycopersicum 69-73 21947299-5 2012 Two genes encoding homologous R2R3 MYB transcription factors, termed ANT1 and AN2, were previously genetically implicated in anthocyanin accumulation in tomato fruit peels of the ANTHOCYANIN FRUIT (AFT) genotype originating from S. chilense. Anthocyanins 125-136 transcription factor MYB75 Solanum lycopersicum 78-81 21947299-5 2012 Two genes encoding homologous R2R3 MYB transcription factors, termed ANT1 and AN2, were previously genetically implicated in anthocyanin accumulation in tomato fruit peels of the ANTHOCYANIN FRUIT (AFT) genotype originating from S. chilense. Anthocyanins 179-190 anthocyanin 1 Solanum lycopersicum 69-73 21947299-5 2012 Two genes encoding homologous R2R3 MYB transcription factors, termed ANT1 and AN2, were previously genetically implicated in anthocyanin accumulation in tomato fruit peels of the ANTHOCYANIN FRUIT (AFT) genotype originating from S. chilense. Anthocyanins 179-190 transcription factor MYB75 Solanum lycopersicum 78-81 21947299-9 2012 In addition, a segregating population obtained from a recombinant genotype revealed that the native ANT1, and not AN2, is fully associated with the AFT phenotype and that ANT1 alone can generate the characteristic phenotype of anthocyanin accumulation in AFT fruits. Anthocyanins 227-238 anthocyanin 1 Solanum lycopersicum 100-104 21947299-9 2012 In addition, a segregating population obtained from a recombinant genotype revealed that the native ANT1, and not AN2, is fully associated with the AFT phenotype and that ANT1 alone can generate the characteristic phenotype of anthocyanin accumulation in AFT fruits. Anthocyanins 227-238 anthocyanin 1 Solanum lycopersicum 171-175 21947299-10 2012 Our results therefore provide further support to the hypothesis that ANT1 is the gene responsible for anthocyanin accumulation in fruits of the AFT genotype. Anthocyanins 102-113 anthocyanin 1 Solanum lycopersicum 69-73 22182640-4 2012 The anthocyanin-rich extract was added to the cells later and subsequently, the supernatant of each cell culture was analysed for the production of tumour necrosis factor-alpha (TNF-alpha), interleukin 1 (IL-1), interleukin 6 (IL-6), nitric oxide, and catalase activity as indices for the activation of macrophages. Anthocyanins 4-15 interleukin 6 Homo sapiens 212-225 22182640-4 2012 The anthocyanin-rich extract was added to the cells later and subsequently, the supernatant of each cell culture was analysed for the production of tumour necrosis factor-alpha (TNF-alpha), interleukin 1 (IL-1), interleukin 6 (IL-6), nitric oxide, and catalase activity as indices for the activation of macrophages. Anthocyanins 4-15 interleukin 6 Homo sapiens 227-231 22126737-4 2012 We recently isolated PAP1-programmed anthocyanin-producing (red) and -free (white) cells from Arabidopsis thaliana; our previous studies have indicated that the PAP1 expression level is similar between these two different cell types. Anthocyanins 37-48 phosphatidic acid phosphatase 1 Arabidopsis thaliana 21-25 22126737-4 2012 We recently isolated PAP1-programmed anthocyanin-producing (red) and -free (white) cells from Arabidopsis thaliana; our previous studies have indicated that the PAP1 expression level is similar between these two different cell types. Anthocyanins 37-48 phosphatidic acid phosphatase 1 Arabidopsis thaliana 161-165 22126737-5 2012 Transcriptional analysis showed that the red cells contain the TTG1-GL3/TT8-PAP1 regulatory complex, which controls anthocyanin biosynthesis; in contrast, the white cells and the wild-type cells lack this entire complex. Anthocyanins 116-127 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 63-67 22126737-5 2012 Transcriptional analysis showed that the red cells contain the TTG1-GL3/TT8-PAP1 regulatory complex, which controls anthocyanin biosynthesis; in contrast, the white cells and the wild-type cells lack this entire complex. Anthocyanins 116-127 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 68-71 22126737-5 2012 Transcriptional analysis showed that the red cells contain the TTG1-GL3/TT8-PAP1 regulatory complex, which controls anthocyanin biosynthesis; in contrast, the white cells and the wild-type cells lack this entire complex. Anthocyanins 116-127 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 72-75 22126737-5 2012 Transcriptional analysis showed that the red cells contain the TTG1-GL3/TT8-PAP1 regulatory complex, which controls anthocyanin biosynthesis; in contrast, the white cells and the wild-type cells lack this entire complex. Anthocyanins 116-127 phosphatidic acid phosphatase 1 Arabidopsis thaliana 76-80 24116277-7 2012 The contribution of autophagy induction to the protective effects of anthocyanin was verified by the observation that silencing the Atg5 expression, an essential regulator of autophagy induction, reversed the cytoprotective effect of anthocyanin extracts against OGD stress. Anthocyanins 69-80 autophagy protein 5 Glycine max 132-136 24116277-7 2012 The contribution of autophagy induction to the protective effects of anthocyanin was verified by the observation that silencing the Atg5 expression, an essential regulator of autophagy induction, reversed the cytoprotective effect of anthocyanin extracts against OGD stress. Anthocyanins 234-245 autophagy protein 5 Glycine max 132-136 21899608-2 2012 Two glycosyltransferases, UGT79B1 and UGT84A2 were found to cluster with anthocyanin biosynthetic genes. Anthocyanins 73-84 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 26-33 21899608-2 2012 Two glycosyltransferases, UGT79B1 and UGT84A2 were found to cluster with anthocyanin biosynthetic genes. Anthocyanins 73-84 UDP-Glycosyltransferase superfamily protein Arabidopsis thaliana 38-45 21899608-3 2012 Anthocyanin was drastically reduced in ugt79b1 knockout mutants. Anthocyanins 0-11 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 39-46 21899608-7 2012 In ugt84a2 knockout mutants, a major sinapoylated anthocyanin was drastically reduced. Anthocyanins 50-61 UDP-Glycosyltransferase superfamily protein Arabidopsis thaliana 3-10 21899608-8 2012 A comparison of anthocyanin profiles in ugt84a knockout mutants indicated that UGT84A2 plays a major role in sinapoylation of anthocyanin, and that other UGT84As contribute the production of 1-O-sinapoylglucose to a lesser extent. Anthocyanins 16-27 UDP-Glycosyltransferase superfamily protein Arabidopsis thaliana 79-86 21899608-8 2012 A comparison of anthocyanin profiles in ugt84a knockout mutants indicated that UGT84A2 plays a major role in sinapoylation of anthocyanin, and that other UGT84As contribute the production of 1-O-sinapoylglucose to a lesser extent. Anthocyanins 126-137 UDP-Glycosyltransferase superfamily protein Arabidopsis thaliana 79-86 21910737-6 2012 Compared to the wild-type and the overexpressor line, the phr1 mutant has decreased levels of phosphate, anthocyanins and carbohydrates during combined P deficiency and light stress. Anthocyanins 105-117 phosphate starvation response 1 Arabidopsis thaliana 58-62 21910737-8 2012 We conclude that PHR1 is needed for the metabolic balance, for retaining P(i) levels and for inducing anthocyanin production, and during P deficiency PHR1 is vital for adaptations to avoid permanent damage to photosystems during high-light conditions. Anthocyanins 103-114 phosphate starvation response 1 Arabidopsis thaliana 17-21 23029369-7 2012 UFGT and MRP were associated with several different types of anthocyanins. Anthocyanins 61-73 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 0-4 22662141-0 2012 Chemical PARP inhibition enhances growth of Arabidopsis and reduces anthocyanin accumulation and the activation of stress protective mechanisms. Anthocyanins 68-79 poly(ADP-ribose) polymerase Arabidopsis thaliana 9-13 22662141-5 2012 The analysis revealed that PARP inhibition represses anthocyanin and ascorbate accumulation under stress conditions. Anthocyanins 53-64 poly(ADP-ribose) polymerase Arabidopsis thaliana 27-31 22662141-10 2012 PARP inhibition allows plants to reduce protection such as anthocyanin, ascorbate or Non-Photochemical-Quenching whilst maintaining high energy levels likely enabling the observed enhancement of biomass production under stress, opening interesting perspectives for increasing crop productivity. Anthocyanins 59-70 poly(ADP-ribose) polymerase Arabidopsis thaliana 0-4 22363419-1 2012 Transgenic tobacco (Nicotiana tabacum) lines were engineered to ectopically over-express AtMYB90 (PAP2), an R2-R3 Myb gene associated with regulation of anthocyanin production in Arabidopsis thaliana. Anthocyanins 153-164 myb domain protein 90 Arabidopsis thaliana 89-96 22363419-2 2012 Independently transformed transgenic lines, Myb27 and Myb237, accumulated large quantities of anthocyanin, generating a dark purple phenotype in nearly all tissues. Anthocyanins 94-105 uncharacterized protein LOC107775040 Nicotiana tabacum 44-47 22363419-5 2012 The observed reduction in anthocyanin pigmentation and AtMYB90 mRNA was phenotypically identical to the patterns seen in leaves systemically silenced for the AtMYB90 transgene, and was associated with the presence of AtMYB90-derived siRNA homologous to both strands of a portion of the AtMYB90 transcribed region. Anthocyanins 26-37 myb domain protein 90 Arabidopsis thaliana 158-165 22363419-5 2012 The observed reduction in anthocyanin pigmentation and AtMYB90 mRNA was phenotypically identical to the patterns seen in leaves systemically silenced for the AtMYB90 transgene, and was associated with the presence of AtMYB90-derived siRNA homologous to both strands of a portion of the AtMYB90 transcribed region. Anthocyanins 26-37 myb domain protein 90 Arabidopsis thaliana 158-165 22363419-5 2012 The observed reduction in anthocyanin pigmentation and AtMYB90 mRNA was phenotypically identical to the patterns seen in leaves systemically silenced for the AtMYB90 transgene, and was associated with the presence of AtMYB90-derived siRNA homologous to both strands of a portion of the AtMYB90 transcribed region. Anthocyanins 26-37 myb domain protein 90 Arabidopsis thaliana 158-165 22493802-8 2012 Anthocyanidin (100 and 50 micromol x L(-1)) obviously suppressed the degranulation from mast cells, whereas results from anthocyanidin (100 and 50 micromol x L(-1)) group indicated significant inhibitory effect on histamine, the calcium uptake, TNF-alpha, IL-6, phosphorylation of NF-kappaB, p38MAPK and Akt of mast cells induced by antigen. Anthocyanins 121-134 tumor necrosis factor Rattus norvegicus 245-254 22493802-8 2012 Anthocyanidin (100 and 50 micromol x L(-1)) obviously suppressed the degranulation from mast cells, whereas results from anthocyanidin (100 and 50 micromol x L(-1)) group indicated significant inhibitory effect on histamine, the calcium uptake, TNF-alpha, IL-6, phosphorylation of NF-kappaB, p38MAPK and Akt of mast cells induced by antigen. Anthocyanins 121-134 interleukin 6 Rattus norvegicus 256-260 22493802-8 2012 Anthocyanidin (100 and 50 micromol x L(-1)) obviously suppressed the degranulation from mast cells, whereas results from anthocyanidin (100 and 50 micromol x L(-1)) group indicated significant inhibitory effect on histamine, the calcium uptake, TNF-alpha, IL-6, phosphorylation of NF-kappaB, p38MAPK and Akt of mast cells induced by antigen. Anthocyanins 121-134 AKT serine/threonine kinase 1 Rattus norvegicus 304-307 22171701-8 2011 In a collection of 32 unrelated cultivars, MybA and AOMT expression profiles correlated with the level of methylated anthocyanin. Anthocyanins 117-128 flavonoid 3',5'-methyltransferase Vitis vinifera 52-56 22171701-12 2011 We report here the identification of novel AOMT variants likely to cause methylated anthocyanin variation. Anthocyanins 84-95 flavonoid 3',5'-methyltransferase Vitis vinifera 43-47 22153059-5 2011 During the roasting process, tree nut isoflavones, flavanols and flavonols were found to be more resistant to heat than the anthocyanins, PAC and trans-resveratrol. Anthocyanins 124-136 NUT midline carcinoma family member 1 Homo sapiens 34-37 22153515-0 2011 Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate-activated protein kinase in human HepG2 cells and obese mice. Anthocyanins 20-32 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 89-137 22153515-8 2011 Anthocyanin fraction significantly increased the phosphorylation of AMPK and acetyl-coenzyme A carboxylase (ACC) in the liver and HepG2 hepatocytes. Anthocyanins 0-11 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 68-72 21340526-1 2011 A mutant allele of the transcription factor gene MYB10 from apple induces anthocyanin production throughout the plant. Anthocyanins 74-85 transcription factor MYB113-like Malus domestica 49-54 21340526-6 2011 Strawberry plants transformed with the MYB10 gene showed anthocyanin accumulation in leaves and roots. Anthocyanins 57-68 transcription factor MYB113-like Malus domestica 39-44 21340526-8 2011 However, acid methanol extracts of potato shoots or roots carrying the MYB10 gene contained up to four times higher anthocyanin content than control plants. Anthocyanins 116-127 transcription factor MYB113-like Malus domestica 71-76 21340526-9 2011 Therefore anthocyanin production as result of the apple MYB10 gene can be used as a selectable marker for apple, strawberry and potato transformation, replacing kanamycin resistance. Anthocyanins 10-21 transcription factor MYB113-like Malus domestica 56-61 22373152-0 2011 Improvement of insulin resistance by Cyanidin 3-glucoside, anthocyanin from black beans through the up-regulation of GLUT4 gene expression. Anthocyanins 59-70 insulin Homo sapiens 15-22 22373152-0 2011 Improvement of insulin resistance by Cyanidin 3-glucoside, anthocyanin from black beans through the up-regulation of GLUT4 gene expression. Anthocyanins 59-70 solute carrier family 2 member 4 Homo sapiens 117-122 22070454-8 2011 We observed a near perfect correlation between the mRNA expression levels of the functional R gene candidate and an UDP-glucose:flavonoid 3-O-glucosyltransferase (UF3GT) gene, which is responsible for the final step in anthocyanin biosynthesis. Anthocyanins 219-230 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 116-161 30634250-4 2011 The multiple partitioning indicated a single ATPE step could isolate the majority of anthocyanins, while removing near to 90% of the free sugars. Anthocyanins 85-97 ATP synthase F1 subunit epsilon Homo sapiens 45-49 30634250-7 2011 Our results indicated that ATPE was a valuable method for the removal of the majority of free sugars, which held great promise in the purification of natural anthocyanin pigments. Anthocyanins 158-169 ATP synthase F1 subunit epsilon Homo sapiens 27-31 22070454-8 2011 We observed a near perfect correlation between the mRNA expression levels of the functional R gene candidate and an UDP-glucose:flavonoid 3-O-glucosyltransferase (UF3GT) gene, which is responsible for the final step in anthocyanin biosynthesis. Anthocyanins 219-230 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 163-168 22053756-5 2011 The effects of anthocyanin co-incubation on CGN survival were assessed. Anthocyanins 15-26 cingulin Rattus norvegicus 44-47 21923118-5 2011 Saline treatment increased the accumulation of total anthocyanins in fruits of Sun Black (2-fold increase), while it reduced it in fruits of Anthocyanin (10-fold decrease). Anthocyanins 53-65 calmodulin binding protein SUN-like Solanum lycopersicum 79-82 21831845-5 2011 Results further demonstrate that EDL3 regulates anthocyanin accumulation under drought stress. Anthocyanins 48-59 EID1-like 3 Arabidopsis thaliana 33-37 22053756-7 2011 Inhibition of Bcl-2 caused a significant reduction of mitochondrial GSH which was prevented by the anthocyanins. Anthocyanins 99-111 BCL2, apoptosis regulator Rattus norvegicus 14-19 22053756-9 2011 MOS-induced mitochondrial fragmentation and proteolytic cleavage of the optic atrophy 1 (OPA1) fusion GTPase were also attenuated by the anthocyanins. Anthocyanins 137-149 OPA1, mitochondrial dynamin like GTPase Rattus norvegicus 72-87 22053756-9 2011 MOS-induced mitochondrial fragmentation and proteolytic cleavage of the optic atrophy 1 (OPA1) fusion GTPase were also attenuated by the anthocyanins. Anthocyanins 137-149 OPA1, mitochondrial dynamin like GTPase Rattus norvegicus 89-93 21671257-6 2011 Cyanidin-3-glucoside (C3G), a member of the anthocyanin family, is a potent natural antioxidant. Anthocyanins 44-55 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 0-25 21643990-0 2011 A pomegranate (Punica granatum L.) WD40-repeat gene is a functional homologue of Arabidopsis TTG1 and is involved in the regulation of anthocyanin biosynthesis during pomegranate fruit development. Anthocyanins 135-146 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 93-97 21643990-3 2011 To identify genes involved in the regulation of anthocyanin biosynthesis pathway in the pomegranate fruit skin we have isolated, expressed and characterized the pomegranate homologue of the Arabidopsis thaliana TRANSPARENT TESTA GLABRA1 (TTG1), encoding a WD40-repeat protein. Anthocyanins 48-59 myb domain protein 0 Arabidopsis thaliana 229-236 21643990-3 2011 To identify genes involved in the regulation of anthocyanin biosynthesis pathway in the pomegranate fruit skin we have isolated, expressed and characterized the pomegranate homologue of the Arabidopsis thaliana TRANSPARENT TESTA GLABRA1 (TTG1), encoding a WD40-repeat protein. Anthocyanins 48-59 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 238-242 21643990-4 2011 The TTG1 protein is a regulator of anthocyanins and proanthocyanidins (PAs) biosynthesis in Arabidopsis, and acts by the formation of a transcriptional regulatory complex with two other regulatory proteins: bHLH and MYB. Anthocyanins 35-47 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 4-8 21643990-5 2011 Our results reveal that the pomegranate gene, designated PgWD40, recovered the anthocyanin, PAs, trichome and seed coat mucilage phenotype in Arabidopsis ttg1 mutant. Anthocyanins 79-90 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 154-158 21785847-0 2011 Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach. Anthocyanins 8-20 BCL2 associated X, apoptosis regulator Homo sapiens 113-116 21785847-6 2011 Actually, pre-incubation of cells with 25 muM anthocyanins prevented them from peroxynitrite-mediated apoptosis, which was evaluated by the loss of mitochondrial membrane potential, caspases-9 and-3 activation, the increase in cytoplasmatic Bax levels and the inactivation of the PI3 K/Akt pathway. Anthocyanins 46-58 caspase 9 Homo sapiens 182-198 21785847-6 2011 Actually, pre-incubation of cells with 25 muM anthocyanins prevented them from peroxynitrite-mediated apoptosis, which was evaluated by the loss of mitochondrial membrane potential, caspases-9 and-3 activation, the increase in cytoplasmatic Bax levels and the inactivation of the PI3 K/Akt pathway. Anthocyanins 46-58 BCL2 associated X, apoptosis regulator Homo sapiens 241-244 21785847-6 2011 Actually, pre-incubation of cells with 25 muM anthocyanins prevented them from peroxynitrite-mediated apoptosis, which was evaluated by the loss of mitochondrial membrane potential, caspases-9 and-3 activation, the increase in cytoplasmatic Bax levels and the inactivation of the PI3 K/Akt pathway. Anthocyanins 46-58 AKT serine/threonine kinase 1 Homo sapiens 286-289 21777625-3 2011 WDR68 was originally identified in petunia as AN11 that controls the pigmentation of flowers by stimulating the transcription of anthocyanin biosynthetic genes. Anthocyanins 129-140 DDB1 and CUL4 associated factor 7 Homo sapiens 0-5 21777625-3 2011 WDR68 was originally identified in petunia as AN11 that controls the pigmentation of flowers by stimulating the transcription of anthocyanin biosynthetic genes. Anthocyanins 129-140 DDB1 and CUL4 associated factor 7 Homo sapiens 46-50 21889055-2 2011 The total polyphenol and anthocyanin contents and the corresponding antioxidant activities were the highest at 13/10 C and 20/13 C, followed by 25/20 C and 30/25 C. The enzymatic activities of polyphenol oxidase (PPO) and phenylalanine ammonia-lyase (PAL) were also the highest at low day/night temperatures, but the peroxidase (POD) activity was decreased at low day/night temperatures and increased at high day/night temperatures. Anthocyanins 25-36 protoporphyrinogen oxidase Homo sapiens 193-211 21889055-2 2011 The total polyphenol and anthocyanin contents and the corresponding antioxidant activities were the highest at 13/10 C and 20/13 C, followed by 25/20 C and 30/25 C. The enzymatic activities of polyphenol oxidase (PPO) and phenylalanine ammonia-lyase (PAL) were also the highest at low day/night temperatures, but the peroxidase (POD) activity was decreased at low day/night temperatures and increased at high day/night temperatures. Anthocyanins 25-36 protoporphyrinogen oxidase Homo sapiens 213-216 21889055-3 2011 The most significant positive correlation existed between anthocyanin content and PPO activity, total polyphenols and their antioxidant activities. Anthocyanins 58-69 protoporphyrinogen oxidase Homo sapiens 82-85 21229312-2 2011 The VvMybA1 gene of grapevine (Vitis vinifera L.) regulates the last metabolic step of anthocyanin biosynthesis and its ectopic expression leads to anthocyanin production in otherwise non-pigmented cells. Anthocyanins 87-98 MYBA1 Vitis vinifera 4-11 21229312-2 2011 The VvMybA1 gene of grapevine (Vitis vinifera L.) regulates the last metabolic step of anthocyanin biosynthesis and its ectopic expression leads to anthocyanin production in otherwise non-pigmented cells. Anthocyanins 148-159 MYBA1 Vitis vinifera 4-11 21229312-3 2011 To develop an anthocyanin-based quantitative reporter system, the VvMybA1 gene was isolated from V. vinifera "Merlot" and placed under control of three promoters to test its ability to distinguish different activity levels. Anthocyanins 14-25 MYBA1 Vitis vinifera 66-73 21736853-0 2011 Strawberry anthocyanin and its association with postprandial inflammation and insulin. Anthocyanins 11-22 insulin Homo sapiens 78-85 21683773-8 2011 Experiments with single and double loss-of-function mutants identified EGL3 and TT8 as necessary regulators of anthocyanin accumulation in developing A. thaliana seedlings. Anthocyanins 111-122 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 71-75 21683773-8 2011 Experiments with single and double loss-of-function mutants identified EGL3 and TT8 as necessary regulators of anthocyanin accumulation in developing A. thaliana seedlings. Anthocyanins 111-122 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 80-83 21788573-4 2011 Dietary anthocyanins have been demonstrated to ameliorate hyperglycemia and insulin sensitivity. Anthocyanins 8-20 insulin Homo sapiens 76-83 21605207-4 2011 We used MYBA1 transformed hairy roots as a grapevine model tissue producing anthocyanins, and took advantage of the unique autofluorescence of anthocyanins to study their cellular trafficking. Anthocyanins 76-88 MYBA1 Vitis vinifera 8-13 21605207-4 2011 We used MYBA1 transformed hairy roots as a grapevine model tissue producing anthocyanins, and took advantage of the unique autofluorescence of anthocyanins to study their cellular trafficking. Anthocyanins 143-155 MYBA1 Vitis vinifera 8-13 21761876-11 2011 Assessment of individual anthocyanins also showed significant effects on p-Akt and p-eNOS. Anthocyanins 25-37 AKT serine/threonine kinase 1 Homo sapiens 75-78 21761876-11 2011 Assessment of individual anthocyanins also showed significant effects on p-Akt and p-eNOS. Anthocyanins 25-37 nitric oxide synthase 3 Homo sapiens 83-89 21484810-8 2011 CONCLUSIONS: PDOs enhanced the color and anthocyanin content of Flame Seedless grape berries possibly due by the induction of PAL mRNA expression. Anthocyanins 41-52 phenylalanine ammonia-lyase Vitis vinifera 126-129 21366597-4 2011 We synthesize current and previous results comparing the variation in dN/dS ratios among members of the MYB-bHLH-WDR complex of TFs that regulates floral anthocyanin pigmentation in Ipomoea. Anthocyanins 154-165 MYB proto-oncogene, transcription factor Homo sapiens 104-107 21586429-5 2011 Expression of the anthocyanin biosynthesis-related genes VvMybA and VvUFGT was linearly related to the decrease in solute potential. Anthocyanins 18-29 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 68-74 21545406-4 2011 It was also shown that the "late" anthocyanin biosynthesis genes including DFR, LDOX, and UF3GT, were induced slightly by JA in the BR mutants relative to wild type. Anthocyanins 34-45 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 90-95 21545406-5 2011 Furthermore, the expression level of JA-induced Myb/bHLH transcription factors such as PAP1, PAP2, and GL3, which are components of the WD-repeat/Myb/bHLH transcriptional complexes that mediate the "late" anthocyanin biosynthesis genes, was lower in the BR mutants than that in wild type. Anthocyanins 205-216 phosphatidic acid phosphatase 1 Arabidopsis thaliana 87-91 21545406-5 2011 Furthermore, the expression level of JA-induced Myb/bHLH transcription factors such as PAP1, PAP2, and GL3, which are components of the WD-repeat/Myb/bHLH transcriptional complexes that mediate the "late" anthocyanin biosynthesis genes, was lower in the BR mutants than that in wild type. Anthocyanins 205-216 Purple acid phosphatases superfamily protein Arabidopsis thaliana 93-97 21545406-5 2011 Furthermore, the expression level of JA-induced Myb/bHLH transcription factors such as PAP1, PAP2, and GL3, which are components of the WD-repeat/Myb/bHLH transcriptional complexes that mediate the "late" anthocyanin biosynthesis genes, was lower in the BR mutants than that in wild type. Anthocyanins 205-216 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 103-106 21395597-7 2011 Anthocyanin accumulation in seedlings grown under far-red light, a typical phenotype of wild-type plants, was reduced in a loss-of-function mutant of PIA2 (pia2), whereas anthocyanin accumulation was increased in an overexpressing plant (PIA2-OX). Anthocyanins 0-11 Ankyrin repeat family protein Arabidopsis thaliana 150-154 21395597-7 2011 Anthocyanin accumulation in seedlings grown under far-red light, a typical phenotype of wild-type plants, was reduced in a loss-of-function mutant of PIA2 (pia2), whereas anthocyanin accumulation was increased in an overexpressing plant (PIA2-OX). Anthocyanins 0-11 Ankyrin repeat family protein Arabidopsis thaliana 156-160 21395597-7 2011 Anthocyanin accumulation in seedlings grown under far-red light, a typical phenotype of wild-type plants, was reduced in a loss-of-function mutant of PIA2 (pia2), whereas anthocyanin accumulation was increased in an overexpressing plant (PIA2-OX). Anthocyanins 0-11 Ankyrin repeat family protein Arabidopsis thaliana 238-242 21395597-8 2011 The gene expression of UDP-flavonoid-3"-glucosyl-transferase (UF3GT), a major enzyme in the anthocyanin biosynthesis processes, was decreased in pia2 knockout plants suggesting that decreased anthocyanin was because of the decreased expression of UF3GT. Anthocyanins 92-103 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 23-60 21395597-8 2011 The gene expression of UDP-flavonoid-3"-glucosyl-transferase (UF3GT), a major enzyme in the anthocyanin biosynthesis processes, was decreased in pia2 knockout plants suggesting that decreased anthocyanin was because of the decreased expression of UF3GT. Anthocyanins 92-103 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 62-67 21395597-8 2011 The gene expression of UDP-flavonoid-3"-glucosyl-transferase (UF3GT), a major enzyme in the anthocyanin biosynthesis processes, was decreased in pia2 knockout plants suggesting that decreased anthocyanin was because of the decreased expression of UF3GT. Anthocyanins 92-103 Ankyrin repeat family protein Arabidopsis thaliana 145-149 21395597-8 2011 The gene expression of UDP-flavonoid-3"-glucosyl-transferase (UF3GT), a major enzyme in the anthocyanin biosynthesis processes, was decreased in pia2 knockout plants suggesting that decreased anthocyanin was because of the decreased expression of UF3GT. Anthocyanins 192-203 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 23-60 21395597-8 2011 The gene expression of UDP-flavonoid-3"-glucosyl-transferase (UF3GT), a major enzyme in the anthocyanin biosynthesis processes, was decreased in pia2 knockout plants suggesting that decreased anthocyanin was because of the decreased expression of UF3GT. Anthocyanins 192-203 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 62-67 21395597-8 2011 The gene expression of UDP-flavonoid-3"-glucosyl-transferase (UF3GT), a major enzyme in the anthocyanin biosynthesis processes, was decreased in pia2 knockout plants suggesting that decreased anthocyanin was because of the decreased expression of UF3GT. Anthocyanins 192-203 Ankyrin repeat family protein Arabidopsis thaliana 145-149 21395597-9 2011 Our results suggest that PIA2 plays a role in the anthocyanin biosynthesis during seedling development as a novel phytochrome-interacting protein. Anthocyanins 50-61 Ankyrin repeat family protein Arabidopsis thaliana 25-29 21484270-7 2011 Ectopic expression of NtAn1a or NtAn1b enhances anthocyanin accumulation in tobacco flowers. Anthocyanins 48-59 basic helix-loop-helix protein A-like Nicotiana tabacum 22-28 21484270-7 2011 Ectopic expression of NtAn1a or NtAn1b enhances anthocyanin accumulation in tobacco flowers. Anthocyanins 48-59 basic helix-loop-helix protein A-like Nicotiana tabacum 32-38 21484270-10 2011 The NtAn1-NtAn2 complex activated the promoters of two key anthocyanin pathway genes, dihydroflavonol reductase and chalcone synthase. Anthocyanins 59-70 annexin D1-like Nicotiana tabacum 4-9 21484270-10 2011 The NtAn1-NtAn2 complex activated the promoters of two key anthocyanin pathway genes, dihydroflavonol reductase and chalcone synthase. Anthocyanins 59-70 transcription factor MYB114-like Nicotiana tabacum 10-15 21484270-12 2011 Our results show that NtAn1 and NtAn2 act in concert to regulate the anthocyanin pathway in tobacco flowers and NtAn2 up-regulates NtAn1 gene expression. Anthocyanins 69-80 annexin D1-like Nicotiana tabacum 22-27 21484270-12 2011 Our results show that NtAn1 and NtAn2 act in concert to regulate the anthocyanin pathway in tobacco flowers and NtAn2 up-regulates NtAn1 gene expression. Anthocyanins 69-80 transcription factor MYB114-like Nicotiana tabacum 32-37 21801362-4 2011 We recently identified and characterized a UDP-glycose:flavonoid-3-O-glycosyltransferase (UGT78K1) from the seed coat of black (iRT) soybean with the aim to engineer seed coat color by suppression of an anthocyanin-specific gene. Anthocyanins 203-214 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 90-97 21801362-5 2011 However, it remained to be investigated whether UGT78K1 was overexpressed with anthocyanin biosynthesis in the black (iRT) seed coat compared to the nearly-isogenic brown (irT) tissue.In this study, we performed a combined analysis of transcriptome and metabolite data to elucidate the control of the R locus over seed coat biochemistry and to identify pigment biosynthesis genes. Anthocyanins 79-90 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 48-55 21801362-8 2011 A global analysis of gene expressions identified UGT78K1 and 19 other anthocyanin, (iso)flavonoid, and phenylpropanoid isogenes to be differentially expressed between isolines. Anthocyanins 70-81 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 49-63 21801362-12 2011 Putative anthocyanin, proanthocyanidin, (iso)flavonoid, and phenylpropanoid isogenes were differentially-expressed between black (iRT) and brown (irT) seed coats, and UGT78K2 and OMT5 were validated to code UDP-glycose:flavonoid-3-O-glycosyltransferase and anthocyanin 3"-O-methyltransferase proteins in vitro, respectively. Anthocyanins 9-20 anthocyanin 3'-O-methyltransferase Glycine max 257-291 21761876-0 2011 Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells. Anthocyanins 24-36 nitric oxide synthase 3 Homo sapiens 58-91 21761876-0 2011 Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells. Anthocyanins 24-36 nitric oxide synthase 3 Homo sapiens 93-97 20932601-0 2011 Both HY5 and HYH are necessary regulators for low temperature-induced anthocyanin accumulation in Arabidopsis seedlings. Anthocyanins 70-81 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 5-8 21599973-6 2011 Transcript levels of the major biosynthetic genes and MYB10, a transcription factor that upregulates apple anthocyanin production, correlated with increased anthocyanin concentration in stripes. Anthocyanins 107-118 transcription factor MYB113-like Malus domestica 54-59 21599973-6 2011 Transcript levels of the major biosynthetic genes and MYB10, a transcription factor that upregulates apple anthocyanin production, correlated with increased anthocyanin concentration in stripes. Anthocyanins 157-168 transcription factor MYB113-like Malus domestica 54-59 21599973-11 2011 CONCLUSIONS: Differences in anthocyanin levels between red and green stripes can be explained by differential transcript accumulation of MYB10. Anthocyanins 28-39 transcription factor MYB113-like Malus domestica 137-142 21385724-0 2011 Identification of the pr1 gene product completes the anthocyanin biosynthesis pathway of maize. Anthocyanins 53-64 pathogenesis related protein 4 Zea mays 22-25 21385724-1 2011 In maize, mutations in the pr1 locus lead to the accumulation of pelargonidin (red) rather than cyanidin (purple) pigments in aleurone cells where the anthocyanin biosynthetic pathway is active. Anthocyanins 151-162 pathogenesis related protein 4 Zea mays 27-30 21385724-7 2011 Genetic and transcription assays demonstrated that the pr1 gene is under the regulatory control of anthocyanin transcription factors red1 and colorless1. Anthocyanins 99-110 pathogenesis related protein 4 Zea mays 55-58 21385724-8 2011 The cloning and characterization of pr1 completes the molecular identification of all genes encoding structural enzymes of the anthocyanin pathway of maize. Anthocyanins 127-138 pathogenesis related protein 4 Zea mays 36-39 21551388-6 2011 Overexpression of the MYB transcription factor MYB75 and bHLH factors (GL3 and EGL3) restored anthocyanin accumulation and trichome initiation in the coi1 mutant, respectively. Anthocyanins 94-105 production of anthocyanin pigment 1 Arabidopsis thaliana 47-52 21551388-6 2011 Overexpression of the MYB transcription factor MYB75 and bHLH factors (GL3 and EGL3) restored anthocyanin accumulation and trichome initiation in the coi1 mutant, respectively. Anthocyanins 94-105 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 71-74 21551388-6 2011 Overexpression of the MYB transcription factor MYB75 and bHLH factors (GL3 and EGL3) restored anthocyanin accumulation and trichome initiation in the coi1 mutant, respectively. Anthocyanins 94-105 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 79-83 21551388-6 2011 Overexpression of the MYB transcription factor MYB75 and bHLH factors (GL3 and EGL3) restored anthocyanin accumulation and trichome initiation in the coi1 mutant, respectively. Anthocyanins 94-105 RNI-like superfamily protein Arabidopsis thaliana 150-154 21210143-8 2011 Microarray and RT-PCR analyses demonstrated that the TTG1-GL3/TT8-PAP1 complex regulated the biosynthesis of anthocyanins. Anthocyanins 109-121 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 53-57 21210143-8 2011 Microarray and RT-PCR analyses demonstrated that the TTG1-GL3/TT8-PAP1 complex regulated the biosynthesis of anthocyanins. Anthocyanins 109-121 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 58-61 21210143-8 2011 Microarray and RT-PCR analyses demonstrated that the TTG1-GL3/TT8-PAP1 complex regulated the biosynthesis of anthocyanins. Anthocyanins 109-121 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 62-65 21210143-8 2011 Microarray and RT-PCR analyses demonstrated that the TTG1-GL3/TT8-PAP1 complex regulated the biosynthesis of anthocyanins. Anthocyanins 109-121 phosphatidic acid phosphatase 1 Arabidopsis thaliana 66-70 21487097-2 2011 Anthocyanins and flavonols are derived from Phe and share common precursors, dihydroflavonols, which are substrates for both flavonol synthase and dihydroflavonol 4-reductase. Anthocyanins 0-12 dihydroflavonol 4-reductase Arabidopsis thaliana 147-174 21487097-6 2011 We further provide evidence that at least one of the miR156 targets, SPL9, negatively regulates anthocyanin accumulation by directly preventing expression of anthocyanin biosynthetic genes through destabilization of a MYB-bHLH-WD40 transcriptional activation complex. Anthocyanins 96-107 squamosa promoter binding protein-like 9 Arabidopsis thaliana 69-73 21487097-6 2011 We further provide evidence that at least one of the miR156 targets, SPL9, negatively regulates anthocyanin accumulation by directly preventing expression of anthocyanin biosynthetic genes through destabilization of a MYB-bHLH-WD40 transcriptional activation complex. Anthocyanins 158-169 squamosa promoter binding protein-like 9 Arabidopsis thaliana 69-73 21673514-4 2011 ( 1) Additionally, we demonstrated that in gun1 seedlings anthocyanin accumulation and the expression of the "early" anthocyanin-biosynthesis genes is perturbed. Anthocyanins 58-69 s uncoupled 1 Arabidopsis thaliana 43-47 21673514-4 2011 ( 1) Additionally, we demonstrated that in gun1 seedlings anthocyanin accumulation and the expression of the "early" anthocyanin-biosynthesis genes is perturbed. Anthocyanins 117-128 s uncoupled 1 Arabidopsis thaliana 43-47 21408135-6 2011 The efficacy of this system was tested using PAP1 (Production of Anthocyanin Pigment 1) transgene, a model transcription factor that regulates the anthocyanin pathway in Arabidopsis. Anthocyanins 147-158 production of anthocyanin pigment 1 Arabidopsis thaliana 45-49 21408135-6 2011 The efficacy of this system was tested using PAP1 (Production of Anthocyanin Pigment 1) transgene, a model transcription factor that regulates the anthocyanin pathway in Arabidopsis. Anthocyanins 147-158 production of anthocyanin pigment 1 Arabidopsis thaliana 51-86 21427283-12 2011 The constitutive photomorphogenic development of the cop1 mutant is enhanced in cop1BBX22ox plants, which show a short hypocotyl, high anthocyanin accumulation, and expression of light-responsive genes. Anthocyanins 135-146 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 53-57 21436041-8 2011 Functional analysis of the Arabidopsis (Arabidopsis thaliana) homologs of NtPYL4, PYL4 and PYL5, indicated that also in Arabidopsis altered PYL expression affected the JA response, both in terms of biomass and anthocyanin production. Anthocyanins 210-221 PYR1-like 4 Arabidopsis thaliana 76-80 21321051-9 2011 Although myc3 and myc4 loss-of-function mutants showed no phenotype, transgenic plants overexpressing MYC3 and MYC4 had higher levels of anthocyanin compared to the wild-type plants. Anthocyanins 137-148 Basic helix-loop-helix (bHLH) DNA-binding family protein Arabidopsis thaliana 102-106 21321051-9 2011 Although myc3 and myc4 loss-of-function mutants showed no phenotype, transgenic plants overexpressing MYC3 and MYC4 had higher levels of anthocyanin compared to the wild-type plants. Anthocyanins 137-148 Basic helix-loop-helix (bHLH) DNA-binding family protein Arabidopsis thaliana 111-115 20932601-0 2011 Both HY5 and HYH are necessary regulators for low temperature-induced anthocyanin accumulation in Arabidopsis seedlings. Anthocyanins 70-81 HY5-homolog Arabidopsis thaliana 13-16 20932601-1 2011 The roles of two bZIP transcription factors LONG HYPOCOTYL 5 (HY5) and HY5 HOMOLOG (HYH) in inducing anthocyanin accumulation during low temperature treatment were studied in Arabidopsis. Anthocyanins 101-112 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 62-65 20932601-1 2011 The roles of two bZIP transcription factors LONG HYPOCOTYL 5 (HY5) and HY5 HOMOLOG (HYH) in inducing anthocyanin accumulation during low temperature treatment were studied in Arabidopsis. Anthocyanins 101-112 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 71-74 20932601-1 2011 The roles of two bZIP transcription factors LONG HYPOCOTYL 5 (HY5) and HY5 HOMOLOG (HYH) in inducing anthocyanin accumulation during low temperature treatment were studied in Arabidopsis. Anthocyanins 101-112 HY5-homolog Arabidopsis thaliana 84-87 20932601-3 2011 In the absence of HY5 or HYH, the low temperature-induced anthocyanin accumulation was significantly impaired compared to that of the wild type. Anthocyanins 58-69 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 18-21 20932601-3 2011 In the absence of HY5 or HYH, the low temperature-induced anthocyanin accumulation was significantly impaired compared to that of the wild type. Anthocyanins 58-69 HY5-homolog Arabidopsis thaliana 25-28 20932601-6 2011 Thus, up-regulation of DFR in a HY5/HYH-dependent manner may address the question of why low temperature-induced anthocyanin accumulation relies upon light. Anthocyanins 113-124 dihydroflavonol 4-reductase Arabidopsis thaliana 23-26 20932601-6 2011 Thus, up-regulation of DFR in a HY5/HYH-dependent manner may address the question of why low temperature-induced anthocyanin accumulation relies upon light. Anthocyanins 113-124 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 32-35 20932601-6 2011 Thus, up-regulation of DFR in a HY5/HYH-dependent manner may address the question of why low temperature-induced anthocyanin accumulation relies upon light. Anthocyanins 113-124 HY5-homolog Arabidopsis thaliana 36-39 20932601-7 2011 In addition, we found that HY5/HYH expression was enhanced by low temperature in wild type Col-0, implying that low temperature induces anthocyanin accumulation, at least in part, through enhancing HY5/HYH protein levels. Anthocyanins 136-147 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 27-30 20932601-7 2011 In addition, we found that HY5/HYH expression was enhanced by low temperature in wild type Col-0, implying that low temperature induces anthocyanin accumulation, at least in part, through enhancing HY5/HYH protein levels. Anthocyanins 136-147 HY5-homolog Arabidopsis thaliana 31-34 20932601-7 2011 In addition, we found that HY5/HYH expression was enhanced by low temperature in wild type Col-0, implying that low temperature induces anthocyanin accumulation, at least in part, through enhancing HY5/HYH protein levels. Anthocyanins 136-147 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 27-34 20932601-8 2011 Collectively, our data suggest that HY5 and HYH are two necessary regulators that play a pivotal role during low temperature-induced anthocyanin accumulation in Arabidopsis seedlings. Anthocyanins 133-144 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 36-39 20932601-8 2011 Collectively, our data suggest that HY5 and HYH are two necessary regulators that play a pivotal role during low temperature-induced anthocyanin accumulation in Arabidopsis seedlings. Anthocyanins 133-144 HY5-homolog Arabidopsis thaliana 44-47 21054438-0 2011 The Arabidopsis tt19-4 mutant differentially accumulates proanthocyanidin and anthocyanin through a 3" amino acid substitution in glutathione S-transferase. Anthocyanins 78-89 glutathione S-transferase phi 12 Arabidopsis thaliana 16-20 21054438-1 2011 The Arabidopsis transparent testa (tt) mutant tt19-4 shows reduced seed coat colour, but stains darkly with DMACA and accumulates anthocyanins in aerial tissues. Anthocyanins 130-142 glutathione S-transferase phi 12 Arabidopsis thaliana 46-50 21054438-5 2011 Transformation of tt19-1 with a TT19-4 cDNA results in vegetative anthocyanins, whereas TT19-4 cDNA cannot complement the proanthocyanidin and pale seed coat phenotype of tt19-1. Anthocyanins 66-78 glutathione S-transferase phi 12 Arabidopsis thaliana 18-22 21054438-5 2011 Transformation of tt19-1 with a TT19-4 cDNA results in vegetative anthocyanins, whereas TT19-4 cDNA cannot complement the proanthocyanidin and pale seed coat phenotype of tt19-1. Anthocyanins 66-78 glutathione S-transferase phi 12 Arabidopsis thaliana 32-36 21054438-8 2011 In addition, TT19 appears to have a 5" GSH-binding domain influencing both anthocyanin and proanthocyanidin accumulation and a 3" domain affecting proanthocyanidin accumulation by a single amino acid substitution. Anthocyanins 75-86 glutathione S-transferase phi 12 Arabidopsis thaliana 13-17 21447791-1 2011 The Arabidopsis thaliana F-box protein CORONATINE INSENSITIVE1 (COI1) perceives jasmonate (JA) signals and subsequently targets the Jasmonate-ZIM domain proteins (JAZs) for degradation by the SCF(COI1)-26S proteasome pathway to mediate various jasmonate-regulated processes, including fertility, root growth, anthocyanin accumulation, senescence, and defense. Anthocyanins 309-320 RNI-like superfamily protein Arabidopsis thaliana 64-68 21235651-2 2011 DEEP PURPLE (DPL) and PURPLE HAZE (PHZ) encode members of the R2R3-MYB transcription factor family that regulate anthocyanin synthesis in petunia, and control anthocyanin production in vegetative tissues and contribute to floral pigmentation. Anthocyanins 113-124 MYB proto-oncogene, transcription factor Homo sapiens 67-70 21235651-2 2011 DEEP PURPLE (DPL) and PURPLE HAZE (PHZ) encode members of the R2R3-MYB transcription factor family that regulate anthocyanin synthesis in petunia, and control anthocyanin production in vegetative tissues and contribute to floral pigmentation. Anthocyanins 159-170 MYB proto-oncogene, transcription factor Homo sapiens 67-70 21447791-1 2011 The Arabidopsis thaliana F-box protein CORONATINE INSENSITIVE1 (COI1) perceives jasmonate (JA) signals and subsequently targets the Jasmonate-ZIM domain proteins (JAZs) for degradation by the SCF(COI1)-26S proteasome pathway to mediate various jasmonate-regulated processes, including fertility, root growth, anthocyanin accumulation, senescence, and defense. Anthocyanins 309-320 RNI-like superfamily protein Arabidopsis thaliana 196-200 21165577-7 2011 Furthermore, the activities of MMP-2 and -9 were dose-dependently suppressed by anthocyanin treatment. Anthocyanins 80-91 matrix metallopeptidase 2 Homo sapiens 31-43 22145036-9 2011 Interestingly, these FLS silenced tobacco lines also showed reduction in their anthocyanidins content. Anthocyanins 79-93 flavonol synthase/flavanone 3-hydroxylase-like Nicotiana tabacum 21-24 21785630-8 2011 Treatment with anthocyanins extract restored IL-10 excretion, as well as caused reduction in the levels of NO, MPO, IL-12, TNF-alpha and IFN-gamma. Anthocyanins 15-27 interleukin 10 Mus musculus 45-50 21785630-8 2011 Treatment with anthocyanins extract restored IL-10 excretion, as well as caused reduction in the levels of NO, MPO, IL-12, TNF-alpha and IFN-gamma. Anthocyanins 15-27 myeloperoxidase Mus musculus 111-114 21785630-8 2011 Treatment with anthocyanins extract restored IL-10 excretion, as well as caused reduction in the levels of NO, MPO, IL-12, TNF-alpha and IFN-gamma. Anthocyanins 15-27 tumor necrosis factor Mus musculus 123-132 21785630-8 2011 Treatment with anthocyanins extract restored IL-10 excretion, as well as caused reduction in the levels of NO, MPO, IL-12, TNF-alpha and IFN-gamma. Anthocyanins 15-27 interferon gamma Mus musculus 137-146 20934476-0 2011 Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression. Anthocyanins 0-12 NFE2 like bZIP transcription factor 2 Rattus norvegicus 109-113 20934476-0 2011 Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression. Anthocyanins 0-12 cytochrome c oxidase II, mitochondrial Rattus norvegicus 156-161 20934476-0 2011 Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression. Anthocyanins 0-12 nitric oxide synthase 2 Rattus norvegicus 166-170 20934476-3 2011 We examined whether an anthocyanin fraction (AF) from purple sweet potato may prevent dimethylnitrosamine (DMN)-induced liver injury by inducing antioxidants via nuclear erythroid 2-related factor 2 (Nrf2) pathways and by reducing inflammation. Anthocyanins 23-34 NFE2 like bZIP transcription factor 2 Rattus norvegicus 200-204 21977025-2 2011 Flavanone 3-hydroxylase (F3H) is a key enzyme at a diverging point of the flavonoid pathway leading to production of different pigments: phlobaphene, proanthocyanidin, and anthocyanin. Anthocyanins 172-183 flavanone 3-dioxygenase 2 Triticum aestivum 0-23 21977025-2 2011 Flavanone 3-hydroxylase (F3H) is a key enzyme at a diverging point of the flavonoid pathway leading to production of different pigments: phlobaphene, proanthocyanidin, and anthocyanin. Anthocyanins 172-183 flavanone 3-dioxygenase 2 Triticum aestivum 25-28 22096315-6 2011 Many alpha-glucosidase inhibitors that are phytoconstituents, such as flavonoids, alkaloids, terpenoids,anthocyanins, glycosides, phenolic compounds, and so on, have been isolated from plants. Anthocyanins 104-116 sucrase-isomaltase Homo sapiens 5-22 20813909-6 2010 Furthermore, fib4 KD trees produced more anthocyanins than the wild type when transferred from low to high light intensity, indicating greater sensitivity to high light stress. Anthocyanins 41-53 Plastid-lipid associated protein PAP / fibrillin family protein Arabidopsis thaliana 13-17 21042741-0 2010 Anthocyanins are novel AMPKalpha1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation. Anthocyanins 0-12 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 23-33 21042741-0 2010 Anthocyanins are novel AMPKalpha1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation. Anthocyanins 0-12 mechanistic target of rapamycin kinase Homo sapiens 87-91 21042741-5 2010 Anthocyanins are naturally-occurring mTOR inhibitor possessing Akt inhibitory activities. Anthocyanins 0-12 mechanistic target of rapamycin kinase Homo sapiens 37-41 21042741-5 2010 Anthocyanins are naturally-occurring mTOR inhibitor possessing Akt inhibitory activities. Anthocyanins 0-12 AKT serine/threonine kinase 1 Homo sapiens 63-66 21042741-6 2010 We have investigated the mTOR inhibitory effect of anthocyanins through the activation of AMPK. Anthocyanins 51-63 mechanistic target of rapamycin kinase Homo sapiens 25-29 21042741-6 2010 We have investigated the mTOR inhibitory effect of anthocyanins through the activation of AMPK. Anthocyanins 51-63 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 90-94 21042741-7 2010 In this study, anthocyanins were applied to colon cancer cells and tumor-bearing xenograft models to investigate their anti-proliferative and pro-apoptotic effects, and elucidate the mechanisms that link AMP-activated protein kinase (AMPK) alpha1 activation to the survival signal of mTOR. Anthocyanins 15-27 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 204-232 21042741-7 2010 In this study, anthocyanins were applied to colon cancer cells and tumor-bearing xenograft models to investigate their anti-proliferative and pro-apoptotic effects, and elucidate the mechanisms that link AMP-activated protein kinase (AMPK) alpha1 activation to the survival signal of mTOR. Anthocyanins 15-27 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 234-238 21042741-7 2010 In this study, anthocyanins were applied to colon cancer cells and tumor-bearing xenograft models to investigate their anti-proliferative and pro-apoptotic effects, and elucidate the mechanisms that link AMP-activated protein kinase (AMPK) alpha1 activation to the survival signal of mTOR. Anthocyanins 15-27 adrenoceptor alpha 1D Homo sapiens 240-246 21042741-7 2010 In this study, anthocyanins were applied to colon cancer cells and tumor-bearing xenograft models to investigate their anti-proliferative and pro-apoptotic effects, and elucidate the mechanisms that link AMP-activated protein kinase (AMPK) alpha1 activation to the survival signal of mTOR. Anthocyanins 15-27 mechanistic target of rapamycin kinase Homo sapiens 284-288 21042741-8 2010 Our results indicated that anthocyanins significantly decreased phospho-mTOR comparable to rapamycin, a synthetic mTOR inhibitor, and this inhibitory effect of anthocyanins on mTOR was completely abrogated by inactivating AMPKalpha1. Anthocyanins 27-39 mechanistic target of rapamycin kinase Homo sapiens 72-76 21042741-8 2010 Our results indicated that anthocyanins significantly decreased phospho-mTOR comparable to rapamycin, a synthetic mTOR inhibitor, and this inhibitory effect of anthocyanins on mTOR was completely abrogated by inactivating AMPKalpha1. Anthocyanins 27-39 mechanistic target of rapamycin kinase Homo sapiens 114-118 21042741-8 2010 Our results indicated that anthocyanins significantly decreased phospho-mTOR comparable to rapamycin, a synthetic mTOR inhibitor, and this inhibitory effect of anthocyanins on mTOR was completely abrogated by inactivating AMPKalpha1. Anthocyanins 27-39 mechanistic target of rapamycin kinase Homo sapiens 114-118 21042741-8 2010 Our results indicated that anthocyanins significantly decreased phospho-mTOR comparable to rapamycin, a synthetic mTOR inhibitor, and this inhibitory effect of anthocyanins on mTOR was completely abrogated by inactivating AMPKalpha1. Anthocyanins 27-39 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 222-232 21042741-8 2010 Our results indicated that anthocyanins significantly decreased phospho-mTOR comparable to rapamycin, a synthetic mTOR inhibitor, and this inhibitory effect of anthocyanins on mTOR was completely abrogated by inactivating AMPKalpha1. Anthocyanins 160-172 mechanistic target of rapamycin kinase Homo sapiens 72-76 21042741-8 2010 Our results indicated that anthocyanins significantly decreased phospho-mTOR comparable to rapamycin, a synthetic mTOR inhibitor, and this inhibitory effect of anthocyanins on mTOR was completely abrogated by inactivating AMPKalpha1. Anthocyanins 160-172 mechanistic target of rapamycin kinase Homo sapiens 114-118 20846146-0 2010 The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae. Anthocyanins 36-48 stress-responsive transcriptional activator MSN2 Saccharomyces cerevisiae S288C 95-99 20846146-0 2010 The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae. Anthocyanins 36-48 stress-responsive transcriptional activator MSN4 Saccharomyces cerevisiae S288C 104-108 20846146-7 2010 Above all, the anthocyanins delphinidin 3-glucoside and petunidin 3-glucoside were found to improve significantly the growth rate of S. cerevisiae in an Msn2-, Msn4-dependent manner, indicating that the stress regulators Msn2 and Msn4 participate in the xenohormetic activity of the wine polyphenols delphinidin and petunidin. Anthocyanins 15-27 stress-responsive transcriptional activator MSN2 Saccharomyces cerevisiae S288C 153-157 20846146-7 2010 Above all, the anthocyanins delphinidin 3-glucoside and petunidin 3-glucoside were found to improve significantly the growth rate of S. cerevisiae in an Msn2-, Msn4-dependent manner, indicating that the stress regulators Msn2 and Msn4 participate in the xenohormetic activity of the wine polyphenols delphinidin and petunidin. Anthocyanins 15-27 stress-responsive transcriptional activator MSN4 Saccharomyces cerevisiae S288C 160-164 20846146-7 2010 Above all, the anthocyanins delphinidin 3-glucoside and petunidin 3-glucoside were found to improve significantly the growth rate of S. cerevisiae in an Msn2-, Msn4-dependent manner, indicating that the stress regulators Msn2 and Msn4 participate in the xenohormetic activity of the wine polyphenols delphinidin and petunidin. Anthocyanins 15-27 stress-responsive transcriptional activator MSN2 Saccharomyces cerevisiae S288C 221-225 20846146-7 2010 Above all, the anthocyanins delphinidin 3-glucoside and petunidin 3-glucoside were found to improve significantly the growth rate of S. cerevisiae in an Msn2-, Msn4-dependent manner, indicating that the stress regulators Msn2 and Msn4 participate in the xenohormetic activity of the wine polyphenols delphinidin and petunidin. Anthocyanins 15-27 stress-responsive transcriptional activator MSN4 Saccharomyces cerevisiae S288C 230-234 20807862-3 2010 MYB75, also called PRODUCTION OF ANTHOCYANIN PIGMENT1, is a known regulator of the anthocyanin branch of the phenylpropanoid pathway in Arabidopsis (Arabidopsis thaliana), but how this regulation might impact other aspects of carbon metabolism is unclear. Anthocyanins 83-94 production of anthocyanin pigment 1 Arabidopsis thaliana 0-5 20876338-6 2010 Suc and light induction of anthocyanin accumulation was almost fully inhibited in wild-type Arabidopsis (Arabidopsis thaliana) ecotype Columbia and ethylene (ethylene response1 [etr1-1]) and light (long hypocotyl1 [hy1], cryptochrome1/2, and hy5) signaling mutants treated with the photosynthetic electron transport inhibitor 3-(3,4-dichlorophenyl)-1,1-dimethylurea. Anthocyanins 27-38 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 221-245 20876338-9 2010 SUC1 mutations lowered accumulations of anthocyanin pigment, soluble sugar content, and ethylene production in response to Suc and light signals. Anthocyanins 40-51 sucrose-proton symporter 1 Arabidopsis thaliana 0-4 20876338-10 2010 These data demonstrate that the suppression of SUC1 expression by ethylene inhibits Suc-induced anthocyanin accumulation in the presence of light and, hence, fine-tunes anthocyanin homeostasis. Anthocyanins 96-107 sucrose-proton symporter 1 Arabidopsis thaliana 47-51 20876338-10 2010 These data demonstrate that the suppression of SUC1 expression by ethylene inhibits Suc-induced anthocyanin accumulation in the presence of light and, hence, fine-tunes anthocyanin homeostasis. Anthocyanins 169-180 sucrose-proton symporter 1 Arabidopsis thaliana 47-51 21189870-2 2010 Supplementation with anthocyanin-rich extracts from black rice or purple sweet potato was reported to attenuate atherosclerotic lesion development in apolipoprotein E-deficient (apo E(-/-)) mice. Anthocyanins 21-32 apolipoprotein E Mus musculus 178-183 21189870-5 2010 The aim of the study was to investigate the impact of bilberry anthocyanin-rich extract (BE) supplementation on gene expression in the liver of apo E(-/-) mice, the widely used model of atherosclerosis. Anthocyanins 63-74 apolipoprotein E Mus musculus 144-149 21042741-8 2010 Our results indicated that anthocyanins significantly decreased phospho-mTOR comparable to rapamycin, a synthetic mTOR inhibitor, and this inhibitory effect of anthocyanins on mTOR was completely abrogated by inactivating AMPKalpha1. Anthocyanins 160-172 mechanistic target of rapamycin kinase Homo sapiens 114-118 21042741-8 2010 Our results indicated that anthocyanins significantly decreased phospho-mTOR comparable to rapamycin, a synthetic mTOR inhibitor, and this inhibitory effect of anthocyanins on mTOR was completely abrogated by inactivating AMPKalpha1. Anthocyanins 160-172 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 222-232 21042741-10 2010 For the first time we have found anthocyanins as novel AMPKalpha1 activators, and in conditions of AMPKalpha1 inactivation, anthocyanins lost their ability to inhibit mTOR in HT-29 colon cancer cells. Anthocyanins 33-45 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 55-65 21042741-10 2010 For the first time we have found anthocyanins as novel AMPKalpha1 activators, and in conditions of AMPKalpha1 inactivation, anthocyanins lost their ability to inhibit mTOR in HT-29 colon cancer cells. Anthocyanins 124-136 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 55-65 21042741-10 2010 For the first time we have found anthocyanins as novel AMPKalpha1 activators, and in conditions of AMPKalpha1 inactivation, anthocyanins lost their ability to inhibit mTOR in HT-29 colon cancer cells. Anthocyanins 124-136 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 99-109 21042741-10 2010 For the first time we have found anthocyanins as novel AMPKalpha1 activators, and in conditions of AMPKalpha1 inactivation, anthocyanins lost their ability to inhibit mTOR in HT-29 colon cancer cells. Anthocyanins 124-136 mechanistic target of rapamycin kinase Homo sapiens 167-171 21042741-11 2010 The activation of AMPKalpha1, and the deactivation of mTOR and Akt were observed in anthocyanins-treated tumor-bearing xenograft models. Anthocyanins 84-96 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 18-28 21042741-11 2010 The activation of AMPKalpha1, and the deactivation of mTOR and Akt were observed in anthocyanins-treated tumor-bearing xenograft models. Anthocyanins 84-96 mechanistic target of rapamycin kinase Homo sapiens 54-58 21042741-11 2010 The activation of AMPKalpha1, and the deactivation of mTOR and Akt were observed in anthocyanins-treated tumor-bearing xenograft models. Anthocyanins 84-96 AKT serine/threonine kinase 1 Homo sapiens 63-66 21042741-12 2010 The results from this study suggest that there is a complex interaction between AMPKalpha1 and mTOR signaling, and anthocyanins are powerful AMPKalpha1 activators that inhibit cancer cell growth by inhibiting mTOR phosphorylation. Anthocyanins 115-127 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 80-90 21042741-12 2010 The results from this study suggest that there is a complex interaction between AMPKalpha1 and mTOR signaling, and anthocyanins are powerful AMPKalpha1 activators that inhibit cancer cell growth by inhibiting mTOR phosphorylation. Anthocyanins 115-127 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 141-151 21042741-12 2010 The results from this study suggest that there is a complex interaction between AMPKalpha1 and mTOR signaling, and anthocyanins are powerful AMPKalpha1 activators that inhibit cancer cell growth by inhibiting mTOR phosphorylation. Anthocyanins 115-127 mechanistic target of rapamycin kinase Homo sapiens 209-213 20935176-4 2010 Further physiological studies indicated that AtGSTU17 participates in various aspects of seedling development, including hypocotyl elongation, anthocyanin accumulation, and far-red light-mediated inhibition of greening with a requirement of functional phyA. Anthocyanins 143-154 Glutathione S-transferase family protein Arabidopsis thaliana 45-53 20855520-6 2010 Up-regulation of Pr specifically activated a basic helix-loop-helix transcription factor and a subset of anthocyanin structural genes encoding flavonoid 3"-hydroxylase, dihydroflavonol 4-reductase, and leucoanthocyanidin dioxygenase to confer ectopic accumulation of pigments in the purple cauliflower. Anthocyanins 105-116 Cytochrome P450 superfamily protein Arabidopsis thaliana 143-167 21034468-6 2010 Cyanidin-3-glucoside (C3G), an anthocyanin present in many vegetables and fruits, is a potent natural antioxidant. Anthocyanins 31-42 Rap guanine nucleotide exchange factor 1 Homo sapiens 0-25 20699397-5 2010 In addition, SR45 is involved in the control of Glc-responsive gene expression, as the mutant displays enhanced repression of photosynthetic and nitrogen metabolism genes and overinduction of starch and anthocyanin biosynthesis genes. Anthocyanins 203-214 arginine/serine-rich 45 Arabidopsis thaliana 13-17 20801663-0 2010 Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I. Anthocyanins 23-36 glyoxalase I Homo sapiens 69-81 20801663-3 2010 Here, we examined the inhibitory abilities to the human GLO I of anthocyanidins, such as delphinidin, cyanidin and pelargonidin. Anthocyanins 65-79 glyoxalase I Homo sapiens 56-61 21103079-4 2010 However, high concentration of hydrogen peroxide (100 microM) downregulated p27 in both cell lines, but delphindin, one of antioxidative anthocyanins, enhanced the level of p27 suppressed by 100 microM hydrogen peroxide. Anthocyanins 137-149 interferon alpha inducible protein 27 Homo sapiens 173-176 20537699-6 2010 Somatic cell nuclear transfer embryos derived from anthocyanin-treated oocytes had increased (P < 0.05) expression of DNMT1, PCNA, FGFR2, and POU5F1 mRNA compared to control embryos. Anthocyanins 51-62 DNA methyltransferase 1 Sus scrofa 121-126 20537699-6 2010 Somatic cell nuclear transfer embryos derived from anthocyanin-treated oocytes had increased (P < 0.05) expression of DNMT1, PCNA, FGFR2, and POU5F1 mRNA compared to control embryos. Anthocyanins 51-62 proliferating cell nuclear antigen Sus scrofa 128-132 20537699-6 2010 Somatic cell nuclear transfer embryos derived from anthocyanin-treated oocytes had increased (P < 0.05) expression of DNMT1, PCNA, FGFR2, and POU5F1 mRNA compared to control embryos. Anthocyanins 51-62 fibroblast growth factor receptor 2 Sus scrofa 134-139 20537699-6 2010 Somatic cell nuclear transfer embryos derived from anthocyanin-treated oocytes had increased (P < 0.05) expression of DNMT1, PCNA, FGFR2, and POU5F1 mRNA compared to control embryos. Anthocyanins 51-62 POU domain, class 5, transcription factor 1 Sus scrofa 145-151 20217837-5 2010 In contrast, treatment with anthocyanins decreased this activation of ERK1/2 and JNK, as confirmed by Western blot analysis, and reduced the production of ROS, as verified by fluorescent microscopic and FACS analyses. Anthocyanins 28-40 mitogen-activated protein kinase 3 Homo sapiens 70-76 20217837-5 2010 In contrast, treatment with anthocyanins decreased this activation of ERK1/2 and JNK, as confirmed by Western blot analysis, and reduced the production of ROS, as verified by fluorescent microscopic and FACS analyses. Anthocyanins 28-40 mitogen-activated protein kinase 8 Homo sapiens 81-84 20566705-5 2010 The pal1 pal2 double mutants were also deficient in anthocyanin pigments in various plant tissues, which accumulate in wild-type plants under stress conditions. Anthocyanins 52-63 PHE ammonia lyase 1 Arabidopsis thaliana 4-8 20217837-6 2010 These findings suggest that anthocyanins, by suppressing JNK, ERK1/2, and intracellular ROS production, have a concentration-dependent antiapoptotic effect on rotator cuff tenofibroblasts exposed to an oxidative stressor, and may have therapeutic potential. Anthocyanins 28-40 mitogen-activated protein kinase 8 Homo sapiens 57-60 20217837-6 2010 These findings suggest that anthocyanins, by suppressing JNK, ERK1/2, and intracellular ROS production, have a concentration-dependent antiapoptotic effect on rotator cuff tenofibroblasts exposed to an oxidative stressor, and may have therapeutic potential. Anthocyanins 28-40 mitogen-activated protein kinase 3 Homo sapiens 62-68 20552703-6 2010 Moreover, it is also proposed that Cat-Vit A pigments arise from the cycloaddition of pyruvic acid to an anthocyanin moiety of a flavanol-anthocyanin adduct rather than by direct nucleophilic attack of a vitisin A on the carbocation C(4) of catechin. Anthocyanins 105-116 catalase Homo sapiens 35-38 20552703-6 2010 Moreover, it is also proposed that Cat-Vit A pigments arise from the cycloaddition of pyruvic acid to an anthocyanin moiety of a flavanol-anthocyanin adduct rather than by direct nucleophilic attack of a vitisin A on the carbocation C(4) of catechin. Anthocyanins 105-116 vitrin Homo sapiens 39-42 20552703-6 2010 Moreover, it is also proposed that Cat-Vit A pigments arise from the cycloaddition of pyruvic acid to an anthocyanin moiety of a flavanol-anthocyanin adduct rather than by direct nucleophilic attack of a vitisin A on the carbocation C(4) of catechin. Anthocyanins 138-149 catalase Homo sapiens 35-38 20552703-6 2010 Moreover, it is also proposed that Cat-Vit A pigments arise from the cycloaddition of pyruvic acid to an anthocyanin moiety of a flavanol-anthocyanin adduct rather than by direct nucleophilic attack of a vitisin A on the carbocation C(4) of catechin. Anthocyanins 138-149 vitrin Homo sapiens 39-42 20580386-1 2010 Cabernet Sauvignon 3",5"-O-methyltransferase showing strong preference for anthocyanins and glycosylated flavonols. Anthocyanins 75-87 O-methyltransferase Vitis vinifera 25-44 20580386-4 2010 In this study, an O-methyltransferase cDNA that showed a distinct expression pattern when compared to closely related sequences was expressed in Escherichia coli and enzyme assays were carried out with a broad array of anthocyanin and other flavonoid substrates. Anthocyanins 219-230 O-methyltransferase Vitis vinifera 18-37 20797319-0 2010 Enhancement of HIV-1 Tat fusion protein transduction efficiency by bog blueberry anthocyanins. Anthocyanins 81-93 Tat Human immunodeficiency virus 1 21-24 20605896-2 2010 gun1 seedlings accumulated less anthocyanin than wild-type seedlings when grown in the presence of 2% (w/v) sucrose, due to lower amounts of transcripts of early anthocyanin biosynthesis genes in gun1. Anthocyanins 32-43 s uncoupled 1 Arabidopsis thaliana 0-4 20605896-2 2010 gun1 seedlings accumulated less anthocyanin than wild-type seedlings when grown in the presence of 2% (w/v) sucrose, due to lower amounts of transcripts of early anthocyanin biosynthesis genes in gun1. Anthocyanins 162-173 s uncoupled 1 Arabidopsis thaliana 0-4 20605896-8 2010 These observations clearly implicate GUN1 and plastid signalling in the regulation of seedling development and anthocyanin biosynthesis, and indicate a complex interplay between sucrose and plastid signalling pathways. Anthocyanins 111-122 s uncoupled 1 Arabidopsis thaliana 37-41 20621794-3 2010 In this study, the full-length cDNA which encodes the enzyme that catalyzes the final step in anthocyanin biosynthesis, namely UDP-glucose:flavonoid 3-O-glucosyltransferase (UGT78K1), was isolated from the seed coat tissue of black soybean using rapid amplification of cDNA ends (RACE). Anthocyanins 94-105 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 127-172 20621794-3 2010 In this study, the full-length cDNA which encodes the enzyme that catalyzes the final step in anthocyanin biosynthesis, namely UDP-glucose:flavonoid 3-O-glucosyltransferase (UGT78K1), was isolated from the seed coat tissue of black soybean using rapid amplification of cDNA ends (RACE). Anthocyanins 94-105 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 174-182 20621794-8 2010 Transfer of UGT78K1 into the Arabidopsis T-DNA mutant (ugt78d2) deficient in anthocyanidin and flavonol 3-O-glucosyltransferase activity, restored the accumulation of anthocyanins and flavonols, suggesting the in vivo function of the enzyme as a flavonoid 3-O-glucosyltransferase. Anthocyanins 77-90 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 12-19 20621794-8 2010 Transfer of UGT78K1 into the Arabidopsis T-DNA mutant (ugt78d2) deficient in anthocyanidin and flavonol 3-O-glucosyltransferase activity, restored the accumulation of anthocyanins and flavonols, suggesting the in vivo function of the enzyme as a flavonoid 3-O-glucosyltransferase. Anthocyanins 167-179 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 12-19 20621794-10 2010 RT-PCR confirmed the co-expression of one of these genes (Glyma08g07130) with UGT78K1 in the seed coat of black soybean, suggesting possible functional redundancies in anthocyanin biosynthesis in this tissue. Anthocyanins 168-179 UDP-glucose:flavonoid 3-O-glucosyltransferase Glycine max 78-85 20566705-5 2010 The pal1 pal2 double mutants were also deficient in anthocyanin pigments in various plant tissues, which accumulate in wild-type plants under stress conditions. Anthocyanins 52-63 phenylalanine ammonia-lyase 2 Arabidopsis thaliana 9-13 20488895-4 2010 In the presence of arsenate, ptlpd1-1 plants exhibited reduced root and shoot growth and enhanced anthocyanin accumulation compared with wild-type plants. Anthocyanins 98-109 lipoamide dehydrogenase 1 Arabidopsis thaliana 29-35 20229526-4 2010 Our results indicate that a proanthocyanin-enriched blackcurrant extract (BC-P), but not anthocyanin-enriched blackcurrant extract suppressed both IL-4- and IL-13-stimulated CCL26 secretion in a dose-dependent manner. Anthocyanins 31-42 interleukin 4 Homo sapiens 147-162 20229526-4 2010 Our results indicate that a proanthocyanin-enriched blackcurrant extract (BC-P), but not anthocyanin-enriched blackcurrant extract suppressed both IL-4- and IL-13-stimulated CCL26 secretion in a dose-dependent manner. Anthocyanins 31-42 C-C motif chemokine ligand 26 Homo sapiens 174-179 20726236-7 2010 The activities of GSH-Px, SOD and CAT increased and MDA content decreased significantly with the increase of anthocyanins in a dose-response relationship. Anthocyanins 109-121 Catalase Drosophila melanogaster 34-37 20309578-0 2010 Features of anthocyanin biosynthesis in pap1-D and wild-type Arabidopsis thaliana plants grown in different light intensity and culture media conditions. Anthocyanins 12-23 phosphatidic acid phosphatase 1 Arabidopsis thaliana 40-44 20118183-4 2010 Transient promoter and yeast two-hybrid assays demonstrated that VvMYC1 physically interacts with MYB5a, MYB5b, MYBA1/A2, and MYBPA1 to induce promoters of flavonoid pathway genes involved in anthocyanin and/or proanthocyanidin (PA) synthesis. Anthocyanins 192-203 Basic helix-loop-helix protein A Vitis vinifera 65-71 20118183-6 2010 Transcript levels of VvMYC1 during berry development correlate with the synthesis of anthocyanins and PAs in skins and seeds of berries, suggesting that VvMYC1 is involved in the regulation of anthocyanins and PA synthesis in these organs. Anthocyanins 85-97 Basic helix-loop-helix protein A Vitis vinifera 21-27 20118183-6 2010 Transcript levels of VvMYC1 during berry development correlate with the synthesis of anthocyanins and PAs in skins and seeds of berries, suggesting that VvMYC1 is involved in the regulation of anthocyanins and PA synthesis in these organs. Anthocyanins 85-97 Basic helix-loop-helix protein A Vitis vinifera 153-159 20118183-6 2010 Transcript levels of VvMYC1 during berry development correlate with the synthesis of anthocyanins and PAs in skins and seeds of berries, suggesting that VvMYC1 is involved in the regulation of anthocyanins and PA synthesis in these organs. Anthocyanins 193-205 Basic helix-loop-helix protein A Vitis vinifera 21-27 20118183-6 2010 Transcript levels of VvMYC1 during berry development correlate with the synthesis of anthocyanins and PAs in skins and seeds of berries, suggesting that VvMYC1 is involved in the regulation of anthocyanins and PA synthesis in these organs. Anthocyanins 193-205 Basic helix-loop-helix protein A Vitis vinifera 153-159 20118183-7 2010 Likewise, transient expression of VvMYC1 and VvMYBA1 induces anthocyanin synthesis in grapevine suspension cells. Anthocyanins 61-72 Basic helix-loop-helix protein A Vitis vinifera 34-40 20118183-7 2010 Likewise, transient expression of VvMYC1 and VvMYBA1 induces anthocyanin synthesis in grapevine suspension cells. Anthocyanins 61-72 MYBA1 Vitis vinifera 45-52 20118183-8 2010 These results suggest that VvMYC1 is part of the transcriptional cascade controlling anthocyanin and PA biosynthesis in grapevine. Anthocyanins 85-96 Basic helix-loop-helix protein A Vitis vinifera 27-33 20309578-2 2010 To accelerate the understanding of these questions, we investigated anthocyanin biosynthesis in rosette leaves of both pap1-D and wild-type (WT) A. thaliana plants grown in nine growth conditions, which were composed of three light intensities (low light, middle light, and high light) and three media derived from MS medium (medium-1, 2, and 3). Anthocyanins 68-79 phosphatidic acid phosphatase 1 Arabidopsis thaliana 119-123 20309578-4 2010 The combined growth conditions of high light and either medium-2 or medium-1 induced the most molecular diversity of anthocyanin structures in rosette leaves of pap1-D plants. Anthocyanins 117-128 phosphatidic acid phosphatase 1 Arabidopsis thaliana 161-165 20309578-6 2010 We detected that the A. thaliana anthocyanin molecule A11 was most likely the first cyanin derived from the multiple modification steps of cyanidin. Anthocyanins 33-44 Chalcone-flavanone isomerase family protein Arabidopsis thaliana 54-57 20309578-10 2010 In the same light intensity condition, the responses of anthocyanin levels and profiling to medium alternation were different between pap1-D and WT plants. Anthocyanins 56-67 phosphatidic acid phosphatase 1 Arabidopsis thaliana 134-138 20302676-3 2010 In apple fruit, skin anthocyanin levels are controlled by a gene called MYBA or MYB1, while the gene determining fruit flesh and foliage anthocyanin has been termed MYB10. Anthocyanins 21-32 transcription factor MYB86-like Malus domestica 80-84 20102149-3 2010 Recent in vitro studies demonstrate that anthocyanins and other flavonoids interact directly with rhodopsin and modulate visual pigment function. Anthocyanins 41-53 rhodopsin Homo sapiens 98-107 20360951-2 2010 Specific members of the large family of plant myb transcription factors have been found to play critical roles in regulating expression of anthocyanin biosynthetic genes and these genes continue to serve as important tools in dissecting the molecular mechanisms of plant gene regulation. Anthocyanins 139-150 uncharacterized protein LOC107775040 Nicotiana tabacum 46-49 20360951-3 2010 FINDINGS: A spontaneous mutation within the coding region of an Arabidopsis 35S::AtMYB90 transgene converted the activator of plant-wide anthocyanin production to a dominant-negative allele (PG-1) that inhibits normal pigment production within tobacco petals. Anthocyanins 137-148 myb domain protein 90 Arabidopsis thaliana 81-88 20360951-8 2010 CONCLUSIONS: Messenger RNA and anthocyanin analysis of PG-1Sh transgenic lines (and PG-1Sh x purple 35S::NtAN2 seedlings) support a model in which the mutant myb transgene product acts as a competitive inhibitor of the native tobacco NtAN2 protein. Anthocyanins 31-42 uncharacterized protein LOC107775040 Nicotiana tabacum 158-161 20202836-2 2010 Additionally, the anthocyanidin, delphinidin, and the flavone, tricetinidin, possessing a pyrogallol function were also revealed to suppress expression of Fc epsilonRI. Anthocyanins 18-31 Fc epsilon receptor Ia Homo sapiens 155-167 20149112-2 2010 Notably, anthocyanins accumulate in the activation-tagging myb96-1d line, suggesting a role of MYB96 in biotic and abiotic stress responses in plants. Anthocyanins 9-21 myb domain protein 96 Arabidopsis thaliana 59-64 20149112-2 2010 Notably, anthocyanins accumulate in the activation-tagging myb96-1d line, suggesting a role of MYB96 in biotic and abiotic stress responses in plants. Anthocyanins 9-21 myb domain protein 96 Arabidopsis thaliana 95-100 20059741-5 2010 We demonstrate that ZmFLS1 is under the control of the anthocyanin (C1/PL1 + R/B) and 3-deoxy flavonoid (P1) transcriptional regulators. Anthocyanins 55-66 anthocyanin regulatory C1 protein Zea mays 68-80 20112051-5 2010 WDR1 contributed positively to the accumulation of anthocyanins when it was overexpressed in A. thaliana, although it was not possible to determine the function of WDR2 by ectopic expression. Anthocyanins 51-63 WD-repeat 1 Vitis vinifera 0-4 20112051-8 2010 In vitro grapevine plantlets grown under high salt concentrations showed a cultivar-dependent response for anthocyanin accumulation, which correlated with the expression of MYBA1-2, MYCA1 and WDR1 genes. Anthocyanins 107-118 MYBA1 Vitis vinifera 173-180 20112051-8 2010 In vitro grapevine plantlets grown under high salt concentrations showed a cultivar-dependent response for anthocyanin accumulation, which correlated with the expression of MYBA1-2, MYCA1 and WDR1 genes. Anthocyanins 107-118 myc anthocyanin regulatory protein Vitis vinifera 182-187 20112051-8 2010 In vitro grapevine plantlets grown under high salt concentrations showed a cultivar-dependent response for anthocyanin accumulation, which correlated with the expression of MYBA1-2, MYCA1 and WDR1 genes. Anthocyanins 107-118 WD-repeat 1 Vitis vinifera 192-196 20157728-3 2010 Ectopic expression in tobacco of heterologous bHLH TF genes, such as maize Lc, leads to increased anthocyanin production in the reproductive tissues, suggesting the presence of a reproductive tissue-specific MYB TF that interacts with the Lc-like bHLH TFs. Anthocyanins 98-109 myb-related protein 3R-1-like Nicotiana tabacum 208-211 20157728-6 2010 Constitutive ectopic expression of NtAn2 induces whole-plant anthocyanin production in tobacco and Arabidopsis. Anthocyanins 61-72 transcription factor MYB114-like Nicotiana tabacum 35-40 20157728-9 2010 Yeast two-hybrid assays demonstrated that NtAn2 can interact with five heterologous bHLH TFs known to induce anthocyanin synthesis in other species including maize, perilla, snapdragon and Arabidopsis. Anthocyanins 109-120 transcription factor MYB114-like Nicotiana tabacum 42-47 20157728-12 2010 These results suggest that NtAn2 is a key gene controlling anthocyanin production in reproductive tissues of tobacco. Anthocyanins 59-70 transcription factor MYB114-like Nicotiana tabacum 27-32 20191364-0 2010 The low phytic acid1-241 (lpa1-241) maize mutation alters the accumulation of anthocyanin pigment in the kernel. Anthocyanins 78-89 inositol-3-phosphate synthase Zea mays 26-30 20191364-8 2010 In fact the lpa1-241 mutant accumulates a higher level of anthocyanins as compared to wild type either in the embryo (about 3.8-fold) or in the aleurone layer (about 0.3-fold) in a genotype able to accumulate anthocyanin. Anthocyanins 58-70 inositol-3-phosphate synthase Zea mays 12-16 20191364-8 2010 In fact the lpa1-241 mutant accumulates a higher level of anthocyanins as compared to wild type either in the embryo (about 3.8-fold) or in the aleurone layer (about 0.3-fold) in a genotype able to accumulate anthocyanin. Anthocyanins 58-69 inositol-3-phosphate synthase Zea mays 12-16 21355205-3 2010 Improve visual function by increasing rhodopsin regeneration and ocular health is the earliest reported bioactivities of anthocyanin. Anthocyanins 121-132 rhodopsin Homo sapiens 38-47 20302676-3 2010 In apple fruit, skin anthocyanin levels are controlled by a gene called MYBA or MYB1, while the gene determining fruit flesh and foliage anthocyanin has been termed MYB10. Anthocyanins 137-148 transcription factor MYB113-like Malus domestica 165-170 20302676-5 2010 RESULTS: We use gene specific primers to show that the three MYB activators of apple anthocyanin (MYB10/MYB1/MYBA) are likely alleles of each other. Anthocyanins 85-96 transcription factor MYB113-like Malus domestica 98-103 20302676-5 2010 RESULTS: We use gene specific primers to show that the three MYB activators of apple anthocyanin (MYB10/MYB1/MYBA) are likely alleles of each other. Anthocyanins 85-96 transcription factor MYB86-like Malus domestica 98-102 20302676-8 2010 The expression of these MYB10 genes correlates with fruit and flower anthocyanin levels. Anthocyanins 69-80 transcription factor MYB113-like Malus domestica 24-29 20030585-1 2010 Anthocyanidin reductase (ANR) from Vitis vinifera catalyzes an NADPH-dependent double reduction of anthocyanidins producing a mixture of (2S,3R)- and (2S,3S)-flavan-3-ols. Anthocyanins 99-113 anthocyanidin reductase ((2S)-flavan-3-ol-forming) Vitis vinifera 0-23 20060287-0 2010 Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase. Anthocyanins 0-11 APC, WNT signaling pathway regulator Mus musculus 70-73 20060287-2 2010 Here the hypothesis was tested that oenocyanin added to the diet can interfere with intestinal adenoma development in the Apc(Min) mouse, a model of intestinal carcinogenesis linked to an Apc mutation. Anthocyanins 36-46 APC, WNT signaling pathway regulator Mus musculus 122-125 20060287-2 2010 Here the hypothesis was tested that oenocyanin added to the diet can interfere with intestinal adenoma development in the Apc(Min) mouse, a model of intestinal carcinogenesis linked to an Apc mutation. Anthocyanins 36-46 APC, WNT signaling pathway regulator Mus musculus 188-191 20060287-8 2010 Expression of Akt in small intestinal adenomas from Apc(Min) mice on oenocyanin was reduced by 54% (P=0.003), when compared to controls. Anthocyanins 69-79 thymoma viral proto-oncogene 1 Mus musculus 14-17 20060287-8 2010 Expression of Akt in small intestinal adenomas from Apc(Min) mice on oenocyanin was reduced by 54% (P=0.003), when compared to controls. Anthocyanins 69-79 APC, WNT signaling pathway regulator Mus musculus 52-55 20060287-11 2010 Akt and pErk might be suitable biomarkers of anthocyanin target organ efficacy. Anthocyanins 45-56 thymoma viral proto-oncogene 1 Mus musculus 0-3 20060287-11 2010 Akt and pErk might be suitable biomarkers of anthocyanin target organ efficacy. Anthocyanins 45-56 eukaryotic translation initiation factor 2 alpha kinase 3 Mus musculus 8-12 20060025-2 2010 The anthocyanins inhibited cell invasion in a dose-dependent manner, as measured by Matrigel invasion assays, by suppression of matrix metalloproteinase (MMP)-2 and MMP-9 expression. Anthocyanins 4-16 matrix metallopeptidase 2 Homo sapiens 128-160 20060025-2 2010 The anthocyanins inhibited cell invasion in a dose-dependent manner, as measured by Matrigel invasion assays, by suppression of matrix metalloproteinase (MMP)-2 and MMP-9 expression. Anthocyanins 4-16 matrix metallopeptidase 9 Homo sapiens 165-170 20060025-3 2010 The anti-invasive activity of the anthocyanins was associated with modulation of constitutive nuclear factor kappaB (NF-kappaB) activation. Anthocyanins 34-46 nuclear factor kappa B subunit 1 Homo sapiens 109-115 20060025-3 2010 The anti-invasive activity of the anthocyanins was associated with modulation of constitutive nuclear factor kappaB (NF-kappaB) activation. Anthocyanins 34-46 nuclear factor kappa B subunit 1 Homo sapiens 117-126 20060025-4 2010 The activation of NF-kappaB triggered by tumor necrosis factor-alpha was also inhibited by the anthocyanins through suppression IkappaBalpha phosphorylation. Anthocyanins 95-107 nuclear factor kappa B subunit 1 Homo sapiens 18-27 20060025-4 2010 The activation of NF-kappaB triggered by tumor necrosis factor-alpha was also inhibited by the anthocyanins through suppression IkappaBalpha phosphorylation. Anthocyanins 95-107 tumor necrosis factor Homo sapiens 41-68 20060025-6 2010 In conclusion, this study suggested that the anthocyanins isolated from fruits of V. coignetiae Pulliat should have anti-invasive activities on human colon cancer cells and the activities should be related to the inhibition of NF-kappaB-regulated proteins such as MMP-2 and MMP-9 expression through the inhibition of NF-kappaB activation. Anthocyanins 45-57 nuclear factor kappa B subunit 1 Homo sapiens 230-236 20060025-6 2010 In conclusion, this study suggested that the anthocyanins isolated from fruits of V. coignetiae Pulliat should have anti-invasive activities on human colon cancer cells and the activities should be related to the inhibition of NF-kappaB-regulated proteins such as MMP-2 and MMP-9 expression through the inhibition of NF-kappaB activation. Anthocyanins 45-57 matrix metallopeptidase 2 Homo sapiens 264-269 20060025-6 2010 In conclusion, this study suggested that the anthocyanins isolated from fruits of V. coignetiae Pulliat should have anti-invasive activities on human colon cancer cells and the activities should be related to the inhibition of NF-kappaB-regulated proteins such as MMP-2 and MMP-9 expression through the inhibition of NF-kappaB activation. Anthocyanins 45-57 matrix metallopeptidase 9 Homo sapiens 274-279 20060025-6 2010 In conclusion, this study suggested that the anthocyanins isolated from fruits of V. coignetiae Pulliat should have anti-invasive activities on human colon cancer cells and the activities should be related to the inhibition of NF-kappaB-regulated proteins such as MMP-2 and MMP-9 expression through the inhibition of NF-kappaB activation. Anthocyanins 45-57 nuclear factor kappa B subunit 1 Homo sapiens 227-236 20029381-11 2010 CONCLUSION: Moro juice anti-obesity effect on fat accumulation cannot be explained only by its anthocyanin content. Anthocyanins 95-106 aldehyde oxidase 1 Mus musculus 12-16 20107808-1 2010 The WD40 repeat protein TRANSPARENT TESTA GLABRA1 (TTG1) is involved in a multitude of developmental and biochemical reactions in Arabidopsis thaliana such as the production of seed coat colour and mucilage, pigmentation by anthocyanins as well as the formation of trichomes and root hairs. Anthocyanins 224-236 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 24-49 20107808-1 2010 The WD40 repeat protein TRANSPARENT TESTA GLABRA1 (TTG1) is involved in a multitude of developmental and biochemical reactions in Arabidopsis thaliana such as the production of seed coat colour and mucilage, pigmentation by anthocyanins as well as the formation of trichomes and root hairs. Anthocyanins 224-236 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 51-55 20107808-6 2010 When transformed into ttg1 mutants of A. thaliana, the apple sequence was able to restore trichome growth, anthocyanin production in young seedlings as well as proanthocyanidin production in seeds. Anthocyanins 107-118 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 22-26 20118109-0 2010 Two R2R3-MYB genes, homologs of Petunia AN2, regulate anthocyanin biosyntheses in flower Tepals, tepal spots and leaves of asiatic hybrid lily. Anthocyanins 54-65 paired box 6 Homo sapiens 40-43 20170107-1 2010 Anthocyanins (cyanidin-3-glucoside (Cy-3-gluc) and delphinidin-3-glucoside (Dp-3-gluc)) and their respective vinylpyranoanthocyanin-catechins (portisins) were studied in order to evaluate the cytotoxicity effect on the estrogen responsive human breast cancer cell line (ER+) MCF-7 and their effect on estrogen receptor (ER-alpha and ER-beta) expression. Anthocyanins 0-12 estrogen receptor 1 Homo sapiens 301-318 20170107-1 2010 Anthocyanins (cyanidin-3-glucoside (Cy-3-gluc) and delphinidin-3-glucoside (Dp-3-gluc)) and their respective vinylpyranoanthocyanin-catechins (portisins) were studied in order to evaluate the cytotoxicity effect on the estrogen responsive human breast cancer cell line (ER+) MCF-7 and their effect on estrogen receptor (ER-alpha and ER-beta) expression. Anthocyanins 0-12 estrogen receptor 1 Homo sapiens 320-328 20170107-1 2010 Anthocyanins (cyanidin-3-glucoside (Cy-3-gluc) and delphinidin-3-glucoside (Dp-3-gluc)) and their respective vinylpyranoanthocyanin-catechins (portisins) were studied in order to evaluate the cytotoxicity effect on the estrogen responsive human breast cancer cell line (ER+) MCF-7 and their effect on estrogen receptor (ER-alpha and ER-beta) expression. Anthocyanins 0-12 estrogen receptor 2 Homo sapiens 333-340 20041285-6 2010 This det1 ( esp1 ) mutation caused no detectable mutant phenotype in the presence of wild-type SPA1, but showed strongly synergistic genetic interaction with the spa1 mutation in the control of seedling photomorphogenesis, anthocyanin accumulation, plant size as well as flowering time. Anthocyanins 223-234 light-mediated development protein 1 / deetiolated1 (DET1) Arabidopsis thaliana 5-9 20041285-6 2010 This det1 ( esp1 ) mutation caused no detectable mutant phenotype in the presence of wild-type SPA1, but showed strongly synergistic genetic interaction with the spa1 mutation in the control of seedling photomorphogenesis, anthocyanin accumulation, plant size as well as flowering time. Anthocyanins 223-234 hydroxyproline-rich glycoprotein family protein Arabidopsis thaliana 12-16 20030585-1 2010 Anthocyanidin reductase (ANR) from Vitis vinifera catalyzes an NADPH-dependent double reduction of anthocyanidins producing a mixture of (2S,3R)- and (2S,3S)-flavan-3-ols. Anthocyanins 99-113 anthocyanidin reductase ((2S)-flavan-3-ol-forming) Vitis vinifera 25-28 20030585-5 2010 In the presence of deuterated coenzyme 4S-NADPD, ANR transforms anthocyanidins into dideuterated flavan-3-ols. Anthocyanins 64-78 anthocyanidin reductase ((2S)-flavan-3-ol-forming) Vitis vinifera 49-52 19496063-2 2010 Each of these anthocyanidins concentration-dependently inhibited vascular endothelial growth factor (VEGF)-induced tube formation in a co-culture of human umbilical vein endothelial cells (HUVECs) and fibroblasts, the effect of each anthocyanidin being significant at 3 and/or 10 microM, while NAC significantly inhibited such tube formation at 1 microM (the only concentration tested). Anthocyanins 14-27 X-linked Kx blood group Homo sapiens 294-297 19906042-5 2010 The visible phenotype of FIB1-2 RNAi lines also includes retarded shoot growth and a deficit in anthocyanin accumulation under stress. Anthocyanins 96-107 fibrillarin 1 Arabidopsis thaliana 25-29 20016937-8 2010 35S:AtMYB44 seedlings exhibited slightly elevated chlorophyll levels and less jasmonate- induced anthocyanin accumulation, demonstrating suppression of jasmonate-mediated responses and enhancement of ABA-mediated responses. Anthocyanins 97-108 myb domain protein r1 Arabidopsis thaliana 4-11 19496063-2 2010 Each of these anthocyanidins concentration-dependently inhibited vascular endothelial growth factor (VEGF)-induced tube formation in a co-culture of human umbilical vein endothelial cells (HUVECs) and fibroblasts, the effect of each anthocyanidin being significant at 3 and/or 10 microM, while NAC significantly inhibited such tube formation at 1 microM (the only concentration tested). Anthocyanins 14-28 vascular endothelial growth factor A Homo sapiens 65-99 19496063-2 2010 Each of these anthocyanidins concentration-dependently inhibited vascular endothelial growth factor (VEGF)-induced tube formation in a co-culture of human umbilical vein endothelial cells (HUVECs) and fibroblasts, the effect of each anthocyanidin being significant at 3 and/or 10 microM, while NAC significantly inhibited such tube formation at 1 microM (the only concentration tested). Anthocyanins 14-28 vascular endothelial growth factor A Homo sapiens 101-105 19496063-2 2010 Each of these anthocyanidins concentration-dependently inhibited vascular endothelial growth factor (VEGF)-induced tube formation in a co-culture of human umbilical vein endothelial cells (HUVECs) and fibroblasts, the effect of each anthocyanidin being significant at 3 and/or 10 microM, while NAC significantly inhibited such tube formation at 1 microM (the only concentration tested). Anthocyanins 14-28 X-linked Kx blood group Homo sapiens 294-297 19496063-2 2010 Each of these anthocyanidins concentration-dependently inhibited vascular endothelial growth factor (VEGF)-induced tube formation in a co-culture of human umbilical vein endothelial cells (HUVECs) and fibroblasts, the effect of each anthocyanidin being significant at 3 and/or 10 microM, while NAC significantly inhibited such tube formation at 1 microM (the only concentration tested). Anthocyanins 14-27 vascular endothelial growth factor A Homo sapiens 65-99 19496063-2 2010 Each of these anthocyanidins concentration-dependently inhibited vascular endothelial growth factor (VEGF)-induced tube formation in a co-culture of human umbilical vein endothelial cells (HUVECs) and fibroblasts, the effect of each anthocyanidin being significant at 3 and/or 10 microM, while NAC significantly inhibited such tube formation at 1 microM (the only concentration tested). Anthocyanins 14-27 vascular endothelial growth factor A Homo sapiens 101-105 19921247-8 2010 In the Myc-DET1 background, DDB1A-3HA overexpression resulted in decreased rescue of dark- and light-grown hypocotyl length, light-grown anthocyanin and chlorophyll levels, adult height and stem number phenotypes. Anthocyanins 137-148 damaged DNA binding protein 1A Arabidopsis thaliana 28-33 19921836-0 2010 Comparative study on iron release from soybean (Glycine max) seed ferritin induced by anthocyanins and ascorbate. Anthocyanins 86-98 ferritin-1, chloroplastic Glycine max 66-74 19808084-9 2010 CONCLUSIONS: The competitive ACE inhibitor activity of the anthocyanins 1 and 2 is reported for the first time. Anthocyanins 59-71 angiotensin I converting enzyme Homo sapiens 29-32 20037491-8 2010 This seems to result from the influence of anthocyanins and possibly other flavonoids on blood pressure, serum level of ET-1, lipids, and oxidative status (GSH-Px, SOD, TBARS). Anthocyanins 43-55 endothelin 1 Homo sapiens 120-124 19922539-0 2009 Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1. Anthocyanins 6-18 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 94-98 19922539-0 2009 Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1. Anthocyanins 6-18 ATP binding cassette subfamily B member 1 Homo sapiens 103-107 19922539-0 2009 Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1. Anthocyanins 23-37 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 94-98 19922539-0 2009 Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1. Anthocyanins 23-37 ATP binding cassette subfamily B member 1 Homo sapiens 103-107 19922539-3 2009 EXPERIMENTAL APPROACH: In the present study, 16 anthocyanins and anthocyanidins were exposed to the human efflux transporters multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), using dye efflux, ATPase and, for BCRP, vesicular transport assays. Anthocyanins 48-60 ATP binding cassette subfamily B member 1 Homo sapiens 158-162 19922539-3 2009 EXPERIMENTAL APPROACH: In the present study, 16 anthocyanins and anthocyanidins were exposed to the human efflux transporters multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), using dye efflux, ATPase and, for BCRP, vesicular transport assays. Anthocyanins 48-60 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 168-200 19922539-3 2009 EXPERIMENTAL APPROACH: In the present study, 16 anthocyanins and anthocyanidins were exposed to the human efflux transporters multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), using dye efflux, ATPase and, for BCRP, vesicular transport assays. Anthocyanins 48-60 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 202-206 19922539-3 2009 EXPERIMENTAL APPROACH: In the present study, 16 anthocyanins and anthocyanidins were exposed to the human efflux transporters multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), using dye efflux, ATPase and, for BCRP, vesicular transport assays. Anthocyanins 48-60 dynein axonemal heavy chain 8 Homo sapiens 227-233 19922539-3 2009 EXPERIMENTAL APPROACH: In the present study, 16 anthocyanins and anthocyanidins were exposed to the human efflux transporters multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), using dye efflux, ATPase and, for BCRP, vesicular transport assays. Anthocyanins 48-60 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 243-247 19922539-3 2009 EXPERIMENTAL APPROACH: In the present study, 16 anthocyanins and anthocyanidins were exposed to the human efflux transporters multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), using dye efflux, ATPase and, for BCRP, vesicular transport assays. Anthocyanins 65-79 ATP binding cassette subfamily B member 1 Homo sapiens 158-162 19922539-3 2009 EXPERIMENTAL APPROACH: In the present study, 16 anthocyanins and anthocyanidins were exposed to the human efflux transporters multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), using dye efflux, ATPase and, for BCRP, vesicular transport assays. Anthocyanins 65-79 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 168-200 19922539-3 2009 EXPERIMENTAL APPROACH: In the present study, 16 anthocyanins and anthocyanidins were exposed to the human efflux transporters multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), using dye efflux, ATPase and, for BCRP, vesicular transport assays. Anthocyanins 65-79 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 202-206 19922539-3 2009 EXPERIMENTAL APPROACH: In the present study, 16 anthocyanins and anthocyanidins were exposed to the human efflux transporters multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), using dye efflux, ATPase and, for BCRP, vesicular transport assays. Anthocyanins 65-79 dynein axonemal heavy chain 8 Homo sapiens 227-233 19922539-3 2009 EXPERIMENTAL APPROACH: In the present study, 16 anthocyanins and anthocyanidins were exposed to the human efflux transporters multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), using dye efflux, ATPase and, for BCRP, vesicular transport assays. Anthocyanins 65-79 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 243-247 19922539-9 2009 CONCLUSIONS AND IMPLICATIONS: Although the anthocyanidins under study may alter pharmacokinetics of drugs that are BCRP substrates, they are less likely to interfere with activities of MDR1 substrates. Anthocyanins 43-57 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 115-119 19922539-9 2009 CONCLUSIONS AND IMPLICATIONS: Although the anthocyanidins under study may alter pharmacokinetics of drugs that are BCRP substrates, they are less likely to interfere with activities of MDR1 substrates. Anthocyanins 43-57 ATP binding cassette subfamily B member 1 Homo sapiens 185-189 19885574-0 2009 Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. Anthocyanins 62-74 AKT serine/threonine kinase 1 Homo sapiens 98-101 19885574-0 2009 Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. Anthocyanins 62-74 mitogen-activated protein kinase 14 Homo sapiens 120-123 19885574-7 2009 In conclusion, this study suggests that the anthocyanins isolated from Vitis coignetiae Pulliat induce apoptosis might at least in part through activating p38-MAPK and suppressing Akt in human colon cancer HCT-116 cells. Anthocyanins 44-56 mitogen-activated protein kinase 14 Homo sapiens 155-158 19885574-7 2009 In conclusion, this study suggests that the anthocyanins isolated from Vitis coignetiae Pulliat induce apoptosis might at least in part through activating p38-MAPK and suppressing Akt in human colon cancer HCT-116 cells. Anthocyanins 44-56 AKT serine/threonine kinase 1 Homo sapiens 180-183 19887540-7 2009 Interestingly, the transcript levels of some genes related to flavonoid biosynthesis and the levels of anthocyanins were significantly increased in Ox-ANAC078 plants and reduced in knockout ANAC078 plants (KO-ANAC078) compared with wild-type plants under HL stress. Anthocyanins 103-115 NAC domain containing protein 2 Arabidopsis thaliana 151-158 19887540-7 2009 Interestingly, the transcript levels of some genes related to flavonoid biosynthesis and the levels of anthocyanins were significantly increased in Ox-ANAC078 plants and reduced in knockout ANAC078 plants (KO-ANAC078) compared with wild-type plants under HL stress. Anthocyanins 103-115 NAC domain containing protein 2 Arabidopsis thaliana 190-197 19887540-7 2009 Interestingly, the transcript levels of some genes related to flavonoid biosynthesis and the levels of anthocyanins were significantly increased in Ox-ANAC078 plants and reduced in knockout ANAC078 plants (KO-ANAC078) compared with wild-type plants under HL stress. Anthocyanins 103-115 NAC domain containing protein 2 Arabidopsis thaliana 190-197 19887540-8 2009 The present findings suggest that ANAC078 protein is associated with the induction of genes related to flavonoid biosynthesis, leading to the accumulation of anthocyanins, in response to HL stress. Anthocyanins 158-170 NAC domain containing protein 2 Arabidopsis thaliana 34-41 19854858-7 2009 Importantly, we observed an increased abundance of TAS4-derived trans-acting small interfering RNAs (ta-siRNAs) in Pi-deficient shoots and uncovered an autoregulatory mechanism of PAP1/MYB75 via miR828 and TAS4-siR81(-) that regulates the biosynthesis of anthocyanin. Anthocyanins 255-266 phosphatidic acid phosphatase 1 Arabidopsis thaliana 180-184 19854858-7 2009 Importantly, we observed an increased abundance of TAS4-derived trans-acting small interfering RNAs (ta-siRNAs) in Pi-deficient shoots and uncovered an autoregulatory mechanism of PAP1/MYB75 via miR828 and TAS4-siR81(-) that regulates the biosynthesis of anthocyanin. Anthocyanins 255-266 production of anthocyanin pigment 1 Arabidopsis thaliana 185-190 19779693-2 2009 It has previously been reported that D maps to a region of chromosome 10 that harbors one or more homologs of Petunia an2, an R2R3 MYB transcription factor that coordinately regulates the expression of multiple anthocyanin biosynthetic genes in the floral limb. Anthocyanins 211-222 AN2 Solanum tuberosum 118-121 19789176-2 2009 Plants harbouring homozygous AtSUC2 null alleles accumulate sugar, starch, and anthocyanin in mature leaves, have severely delayed development and stunted growth and, in previous studies, failed to complete their life cycle by producing viable seed. Anthocyanins 79-90 sucrose-proton symporter 2 Arabidopsis thaliana 29-35 19772852-1 2009 Anthocyanidin reductase from Vitis vinifera catalyzes an NADPH-dependent double reduction of anthocyanidins. Anthocyanins 93-107 anthocyanidin reductase ((2S)-flavan-3-ol-forming) Vitis vinifera 0-23 19785001-0 2009 Absorption of anthocyanins through intestinal epithelial cells - Putative involvement of GLUT2. Anthocyanins 14-26 solute carrier family 2 member 2 Homo sapiens 89-94 19933203-4 2009 We report that three N/NO(3)(-)-induced members of the LATERAL ORGAN BOUNDARY DOMAIN (LBD) gene family of transcription factors (LBD37, LBD38, and LBD39) act as negative regulators of anthocyanin biosynthesis in Arabidopsis thaliana. Anthocyanins 184-195 LOB domain-containing protein 37 Arabidopsis thaliana 129-134 19933203-4 2009 We report that three N/NO(3)(-)-induced members of the LATERAL ORGAN BOUNDARY DOMAIN (LBD) gene family of transcription factors (LBD37, LBD38, and LBD39) act as negative regulators of anthocyanin biosynthesis in Arabidopsis thaliana. Anthocyanins 184-195 LOB domain-containing protein 39 Arabidopsis thaliana 147-152 19933203-5 2009 Overexpression of each of the three genes in the absence of N/NO(3)(-) strongly suppresses the key regulators of anthocyanin synthesis PAP1 and PAP2, genes in the anthocyanin-specific part of flavonoid synthesis, as well as cyanidin- but not quercetin- or kaempferol-glycoside production. Anthocyanins 113-124 phosphatidic acid phosphatase 1 Arabidopsis thaliana 135-139 19933203-5 2009 Overexpression of each of the three genes in the absence of N/NO(3)(-) strongly suppresses the key regulators of anthocyanin synthesis PAP1 and PAP2, genes in the anthocyanin-specific part of flavonoid synthesis, as well as cyanidin- but not quercetin- or kaempferol-glycoside production. Anthocyanins 113-124 Purple acid phosphatases superfamily protein Arabidopsis thaliana 144-148 19933203-5 2009 Overexpression of each of the three genes in the absence of N/NO(3)(-) strongly suppresses the key regulators of anthocyanin synthesis PAP1 and PAP2, genes in the anthocyanin-specific part of flavonoid synthesis, as well as cyanidin- but not quercetin- or kaempferol-glycoside production. Anthocyanins 163-174 phosphatidic acid phosphatase 1 Arabidopsis thaliana 135-139 19933203-5 2009 Overexpression of each of the three genes in the absence of N/NO(3)(-) strongly suppresses the key regulators of anthocyanin synthesis PAP1 and PAP2, genes in the anthocyanin-specific part of flavonoid synthesis, as well as cyanidin- but not quercetin- or kaempferol-glycoside production. Anthocyanins 163-174 Purple acid phosphatases superfamily protein Arabidopsis thaliana 144-148 19933203-6 2009 Conversely, lbd37, lbd38, or lbd39 mutants accumulate anthocyanins when grown in N/NO(3)(-)-sufficient conditions and show constitutive expression of anthocyanin biosynthetic genes. Anthocyanins 54-66 LOB domain-containing protein 37 Arabidopsis thaliana 12-17 19933203-6 2009 Conversely, lbd37, lbd38, or lbd39 mutants accumulate anthocyanins when grown in N/NO(3)(-)-sufficient conditions and show constitutive expression of anthocyanin biosynthetic genes. Anthocyanins 54-66 LOB domain-containing protein 38 Arabidopsis thaliana 19-24 19933203-6 2009 Conversely, lbd37, lbd38, or lbd39 mutants accumulate anthocyanins when grown in N/NO(3)(-)-sufficient conditions and show constitutive expression of anthocyanin biosynthetic genes. Anthocyanins 54-66 LOB domain-containing protein 39 Arabidopsis thaliana 29-34 19933203-6 2009 Conversely, lbd37, lbd38, or lbd39 mutants accumulate anthocyanins when grown in N/NO(3)(-)-sufficient conditions and show constitutive expression of anthocyanin biosynthetic genes. Anthocyanins 54-65 LOB domain-containing protein 37 Arabidopsis thaliana 12-17 19933203-6 2009 Conversely, lbd37, lbd38, or lbd39 mutants accumulate anthocyanins when grown in N/NO(3)(-)-sufficient conditions and show constitutive expression of anthocyanin biosynthetic genes. Anthocyanins 54-65 LOB domain-containing protein 38 Arabidopsis thaliana 19-24 19933203-6 2009 Conversely, lbd37, lbd38, or lbd39 mutants accumulate anthocyanins when grown in N/NO(3)(-)-sufficient conditions and show constitutive expression of anthocyanin biosynthetic genes. Anthocyanins 54-65 LOB domain-containing protein 39 Arabidopsis thaliana 29-34 19933203-8 2009 The results identify LBD37 and its two close homologs as novel repressors of anthocyanin biosynthesis and N availability signals in general. Anthocyanins 77-88 LOB domain-containing protein 37 Arabidopsis thaliana 21-26 18789665-0 2009 Red wine anthocyanins are rapidly absorbed in humans and affect monocyte chemoattractant protein 1 levels and antioxidant capacity of plasma. Anthocyanins 9-21 C-C motif chemokine ligand 2 Homo sapiens 64-98 19703423-4 2009 A reduction in the level of anthocyanin was detected and the severity of abnormal flavonoid phenotype correlates well with the increased expression level of AtCPC gene. Anthocyanins 28-39 Homeodomain-like superfamily protein Arabidopsis thaliana 157-162 19703423-6 2009 Furthermore, AtCPC could interact with other known anthocyanin regulators. Anthocyanins 51-62 Homeodomain-like superfamily protein Arabidopsis thaliana 13-18 19703423-7 2009 Our data suggest that in a heterologous host, AtCPC acts as a repressor of anthocyanin production, from which a new evidence for better understanding of the transcriptional regulation of flavonoid biosynthesis and, an implication for the development of new varieties of tobacco and other commercially important ornamental plants are provided. Anthocyanins 75-86 Homeodomain-like superfamily protein Arabidopsis thaliana 46-51 19857058-4 2009 Taken together, the results of this study indicate that the anthocyanins isolated from fruits of V. coignetiae Pulliat have anti-invasive effects on human hepatoma Hep3B cells and inhibit MMP-2 and MMP-9 gene expression at least in part through the inhibition of NF-kappaB activation. Anthocyanins 60-72 matrix metallopeptidase 2 Homo sapiens 188-193 19857058-4 2009 Taken together, the results of this study indicate that the anthocyanins isolated from fruits of V. coignetiae Pulliat have anti-invasive effects on human hepatoma Hep3B cells and inhibit MMP-2 and MMP-9 gene expression at least in part through the inhibition of NF-kappaB activation. Anthocyanins 60-72 matrix metallopeptidase 9 Homo sapiens 198-203 19857058-4 2009 Taken together, the results of this study indicate that the anthocyanins isolated from fruits of V. coignetiae Pulliat have anti-invasive effects on human hepatoma Hep3B cells and inhibit MMP-2 and MMP-9 gene expression at least in part through the inhibition of NF-kappaB activation. Anthocyanins 60-72 nuclear factor kappa B subunit 1 Homo sapiens 263-272 19640950-0 2009 Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Anthocyanins 0-11 cholesteryl ester transfer protein Homo sapiens 117-151 19640950-7 2009 Anthocyanin supplementation decreased the mass and activity of plasma cholesteryl ester transfer protein (CETP) (10.4% and 6.3%, respectively, in the anthocyanin group and -3.5% and 1.1%, respectively, in the placebo group; P < 0.001). Anthocyanins 0-11 cholesteryl ester transfer protein Homo sapiens 70-104 19640950-7 2009 Anthocyanin supplementation decreased the mass and activity of plasma cholesteryl ester transfer protein (CETP) (10.4% and 6.3%, respectively, in the anthocyanin group and -3.5% and 1.1%, respectively, in the placebo group; P < 0.001). Anthocyanins 0-11 cholesteryl ester transfer protein Homo sapiens 106-110 19640950-7 2009 Anthocyanin supplementation decreased the mass and activity of plasma cholesteryl ester transfer protein (CETP) (10.4% and 6.3%, respectively, in the anthocyanin group and -3.5% and 1.1%, respectively, in the placebo group; P < 0.001). Anthocyanins 150-161 cholesteryl ester transfer protein Homo sapiens 106-110 19640950-8 2009 In the anthocyanin group, the change in HDL cholesterol was negatively correlated with the change in CETP activity (r(s) = -0.330). Anthocyanins 7-18 cholesteryl ester transfer protein Homo sapiens 101-105 19649692-3 2009 The present study addresses secretory phospholipase A(2) (sPLA(2)) as a novel candidate effector of neuroprotection conferred by anthocyanins and anthocyanidins. Anthocyanins 129-141 phospholipase A2 group X Homo sapiens 28-56 19649692-3 2009 The present study addresses secretory phospholipase A(2) (sPLA(2)) as a novel candidate effector of neuroprotection conferred by anthocyanins and anthocyanidins. Anthocyanins 129-141 phospholipase A2 group X Homo sapiens 58-65 19649692-3 2009 The present study addresses secretory phospholipase A(2) (sPLA(2)) as a novel candidate effector of neuroprotection conferred by anthocyanins and anthocyanidins. Anthocyanins 146-160 phospholipase A2 group X Homo sapiens 28-56 19649692-3 2009 The present study addresses secretory phospholipase A(2) (sPLA(2)) as a novel candidate effector of neuroprotection conferred by anthocyanins and anthocyanidins. Anthocyanins 146-160 phospholipase A2 group X Homo sapiens 58-65 19621239-0 2009 The endogenous GL3, but not EGL3, gene is necessary for anthocyanin accumulation as induced by nitrogen depletion in Arabidopsis rosette stage leaves. Anthocyanins 56-67 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 15-18 19621239-1 2009 The bHLH transcription factors EGL3 (ENHANCER OF GLABRA3) and its close homologue GL3 (GLABRA3) are important regulators of the anthocyanin pathway in Arabidopsis thaliana, and together with TTG1 (a WD40 repeat protein) and MYB transcription factors regulate specific genes in the pathway. Anthocyanins 128-139 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 31-35 19621239-1 2009 The bHLH transcription factors EGL3 (ENHANCER OF GLABRA3) and its close homologue GL3 (GLABRA3) are important regulators of the anthocyanin pathway in Arabidopsis thaliana, and together with TTG1 (a WD40 repeat protein) and MYB transcription factors regulate specific genes in the pathway. Anthocyanins 128-139 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 37-56 19621239-1 2009 The bHLH transcription factors EGL3 (ENHANCER OF GLABRA3) and its close homologue GL3 (GLABRA3) are important regulators of the anthocyanin pathway in Arabidopsis thaliana, and together with TTG1 (a WD40 repeat protein) and MYB transcription factors regulate specific genes in the pathway. Anthocyanins 128-139 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 32-35 19621239-1 2009 The bHLH transcription factors EGL3 (ENHANCER OF GLABRA3) and its close homologue GL3 (GLABRA3) are important regulators of the anthocyanin pathway in Arabidopsis thaliana, and together with TTG1 (a WD40 repeat protein) and MYB transcription factors regulate specific genes in the pathway. Anthocyanins 128-139 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 49-56 19621239-1 2009 The bHLH transcription factors EGL3 (ENHANCER OF GLABRA3) and its close homologue GL3 (GLABRA3) are important regulators of the anthocyanin pathway in Arabidopsis thaliana, and together with TTG1 (a WD40 repeat protein) and MYB transcription factors regulate specific genes in the pathway. Anthocyanins 128-139 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 191-195 19621239-2 2009 In response to nitrogen depletion, the MYB genes PAP1/PAP2 (production of anthocyanin pigment 1/2) and GL3 are strongly induced, and anthocyanin synthesis is activated in seedlings and rosette stage plants. Anthocyanins 74-85 phosphatidic acid phosphatase 1 Arabidopsis thaliana 49-53 19621239-2 2009 In response to nitrogen depletion, the MYB genes PAP1/PAP2 (production of anthocyanin pigment 1/2) and GL3 are strongly induced, and anthocyanin synthesis is activated in seedlings and rosette stage plants. Anthocyanins 74-85 Purple acid phosphatases superfamily protein Arabidopsis thaliana 54-58 19621239-3 2009 In this study we show that anthocyanins accumulate in both wild type and egl3, but not in gl3 loss-of-function mutants when depleted of nitrogen. Anthocyanins 27-39 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 73-77 19621239-3 2009 In this study we show that anthocyanins accumulate in both wild type and egl3, but not in gl3 loss-of-function mutants when depleted of nitrogen. Anthocyanins 27-39 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 74-77 19621239-6 2009 Hence, low expression of DFR appears to be the bottleneck preventing anthocyanin synthesis in the gl3 mutant. Anthocyanins 69-80 dihydroflavonol 4-reductase Arabidopsis thaliana 25-28 19621239-6 2009 Hence, low expression of DFR appears to be the bottleneck preventing anthocyanin synthesis in the gl3 mutant. Anthocyanins 69-80 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 98-101 19588118-3 2009 A related locus, P, is required for production of blue/purple anthocyanins; P is epistatic to R. We have previously reported that the dihydroflavonol 4-reductase gene (dfr) co-segregates with R. To test directly whether R corresponds to dfr, we placed the allele of dfr associated with red color under the control of the CaMV 35S promoter and introduced it into the potato cultivar Prince Hairy (genotype dddd rrrr P-), which has white tubers and pale blue flowers. Anthocyanins 62-74 dihydroflavonol-4-reductase Solanum tuberosum 168-171 19588118-8 2009 Thus, dfr can fully complement R, both in terms of tuber color and anthocyanin composition. Anthocyanins 67-78 dihydroflavonol-4-reductase Solanum tuberosum 6-9 19723048-4 2009 It was found that the anthocyanins could inhibit cell growth by 75% at the concentration of 400 microg/mL for 48 h. Flow cytometric analysis showed that the anthocyanins increased the amount of DNA fragments (sub-G1 fraction) in a dose-dependent manner, which is closely related to mitochondrial dysfunction and reduction in antiapoptotic proteins (Bcl-2, xIAP, cIAP-1, and cIAP-2). Anthocyanins 22-34 BCL2 apoptosis regulator Homo sapiens 349-354 19723048-4 2009 It was found that the anthocyanins could inhibit cell growth by 75% at the concentration of 400 microg/mL for 48 h. Flow cytometric analysis showed that the anthocyanins increased the amount of DNA fragments (sub-G1 fraction) in a dose-dependent manner, which is closely related to mitochondrial dysfunction and reduction in antiapoptotic proteins (Bcl-2, xIAP, cIAP-1, and cIAP-2). Anthocyanins 22-34 X-linked inhibitor of apoptosis Homo sapiens 356-360 19723048-4 2009 It was found that the anthocyanins could inhibit cell growth by 75% at the concentration of 400 microg/mL for 48 h. Flow cytometric analysis showed that the anthocyanins increased the amount of DNA fragments (sub-G1 fraction) in a dose-dependent manner, which is closely related to mitochondrial dysfunction and reduction in antiapoptotic proteins (Bcl-2, xIAP, cIAP-1, and cIAP-2). Anthocyanins 22-34 baculoviral IAP repeat containing 2 Homo sapiens 362-368 19723048-4 2009 It was found that the anthocyanins could inhibit cell growth by 75% at the concentration of 400 microg/mL for 48 h. Flow cytometric analysis showed that the anthocyanins increased the amount of DNA fragments (sub-G1 fraction) in a dose-dependent manner, which is closely related to mitochondrial dysfunction and reduction in antiapoptotic proteins (Bcl-2, xIAP, cIAP-1, and cIAP-2). Anthocyanins 22-34 baculoviral IAP repeat containing 3 Homo sapiens 374-380 19723048-4 2009 It was found that the anthocyanins could inhibit cell growth by 75% at the concentration of 400 microg/mL for 48 h. Flow cytometric analysis showed that the anthocyanins increased the amount of DNA fragments (sub-G1 fraction) in a dose-dependent manner, which is closely related to mitochondrial dysfunction and reduction in antiapoptotic proteins (Bcl-2, xIAP, cIAP-1, and cIAP-2). Anthocyanins 157-169 BCL2 apoptosis regulator Homo sapiens 349-354 19723048-4 2009 It was found that the anthocyanins could inhibit cell growth by 75% at the concentration of 400 microg/mL for 48 h. Flow cytometric analysis showed that the anthocyanins increased the amount of DNA fragments (sub-G1 fraction) in a dose-dependent manner, which is closely related to mitochondrial dysfunction and reduction in antiapoptotic proteins (Bcl-2, xIAP, cIAP-1, and cIAP-2). Anthocyanins 157-169 X-linked inhibitor of apoptosis Homo sapiens 356-360 19723048-4 2009 It was found that the anthocyanins could inhibit cell growth by 75% at the concentration of 400 microg/mL for 48 h. Flow cytometric analysis showed that the anthocyanins increased the amount of DNA fragments (sub-G1 fraction) in a dose-dependent manner, which is closely related to mitochondrial dysfunction and reduction in antiapoptotic proteins (Bcl-2, xIAP, cIAP-1, and cIAP-2). Anthocyanins 157-169 baculoviral IAP repeat containing 2 Homo sapiens 362-368 19723048-4 2009 It was found that the anthocyanins could inhibit cell growth by 75% at the concentration of 400 microg/mL for 48 h. Flow cytometric analysis showed that the anthocyanins increased the amount of DNA fragments (sub-G1 fraction) in a dose-dependent manner, which is closely related to mitochondrial dysfunction and reduction in antiapoptotic proteins (Bcl-2, xIAP, cIAP-1, and cIAP-2). Anthocyanins 157-169 baculoviral IAP repeat containing 3 Homo sapiens 374-380 18789665-10 2009 Total urinary excretion of red wine anthocyanins was 0.05+/-0.01% of the administered dose within 24 h. About 94% of the excreted anthocyanins was found in urine within 6 h. In spite of the low concentration of anthocyanins found in plasma, an increase in the antioxidant capacity and a decrease in MCP-1 circulating levels in plasma were observed. Anthocyanins 36-48 C-C motif chemokine ligand 2 Homo sapiens 299-304 19825656-0 2009 CPC, a single-repeat R3 MYB, is a negative regulator of anthocyanin biosynthesis in Arabidopsis. Anthocyanins 56-67 Homeodomain-like superfamily protein Arabidopsis thaliana 0-3 19825656-3 2009 We show here that CPC is a negative regulator of anthocyanin biosynthesis. Anthocyanins 49-60 Homeodomain-like superfamily protein Arabidopsis thaliana 18-21 19825656-4 2009 In the process of using CPC to test GAL4-dependent driver lines, we observed a repression of anthocyanin synthesis upon GAL4-mediated CPC overexpression. Anthocyanins 93-104 Homeodomain-like superfamily protein Arabidopsis thaliana 24-27 19825656-4 2009 In the process of using CPC to test GAL4-dependent driver lines, we observed a repression of anthocyanin synthesis upon GAL4-mediated CPC overexpression. Anthocyanins 93-104 Homeodomain-like superfamily protein Arabidopsis thaliana 134-137 19825656-6 2009 Rather, CPC expression level tightly controls anthocyanin accumulation. Anthocyanins 46-57 Homeodomain-like superfamily protein Arabidopsis thaliana 8-11 19825656-9 2009 Also, anthocyanin synthesis genes were shown to be down-regulated in 35S::CPC overexpression plants. Anthocyanins 6-17 Homeodomain-like superfamily protein Arabidopsis thaliana 74-77 19825656-10 2009 Transient expression results suggest that CPC competes with the R2R3-MYB transcription factor PAP1/2, which is an activator of anthocyanin biosynthesis genes. Anthocyanins 127-138 Homeodomain-like superfamily protein Arabidopsis thaliana 42-45 19825656-10 2009 Transient expression results suggest that CPC competes with the R2R3-MYB transcription factor PAP1/2, which is an activator of anthocyanin biosynthesis genes. Anthocyanins 127-138 purple acid phosphatase 12 Arabidopsis thaliana 94-100 19825656-11 2009 This report adds anthocyanin biosynthesis to the set of programs that are under CPC control, indicating that this regulator is not only for developmental programs (e.g. root hairs, trichomes), but can influence anthocyanin pigment synthesis. Anthocyanins 17-28 Homeodomain-like superfamily protein Arabidopsis thaliana 80-83 19825656-11 2009 This report adds anthocyanin biosynthesis to the set of programs that are under CPC control, indicating that this regulator is not only for developmental programs (e.g. root hairs, trichomes), but can influence anthocyanin pigment synthesis. Anthocyanins 211-222 Homeodomain-like superfamily protein Arabidopsis thaliana 80-83 19363602-6 2009 The potato homolog of Petunia an1, a basic helix-loop-helix (bHLH) transcriptional regulator of anthocyanin biosynthesis, was found to co-localize with the QTL on chromosome 9. Anthocyanins 96-107 transcription factor TT8-like Solanum tuberosum 61-65 19415657-2 2009 We conducted intestinal epithelial cell (Caco-2 cells) culture experiments, which indicated that after a 4 h incubation of anthocyanins in cell-free culture media (DMEM), 57% of the initial cyanidin-3-glucoside (C3G) and 96% of cyanidin had degraded. Anthocyanins 123-135 Rap guanine nucleotide exchange factor 1 Homo sapiens 190-215 19156716-11 2009 Other candidate genes including basic-helix-loop-helix (bHLH), NAM/CUC2-like protein and bZIP transcription factor underlying the mapped anthocyanins were identified. Anthocyanins 137-149 SH3 and cysteine rich domain 3 Homo sapiens 63-66 19416630-0 2009 Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B. Anthocyanins 6-18 monoamine oxidase A Homo sapiens 46-72 19384566-7 2009 Cyanidin-3-glucoside (C3G), a member of the anthocyanin family rich in many edible berries and other pigmented fruits, enhanced neurite outgrowth by promoting p-GSK3beta(Ser9). Anthocyanins 44-55 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 0-25 19384566-7 2009 Cyanidin-3-glucoside (C3G), a member of the anthocyanin family rich in many edible berries and other pigmented fruits, enhanced neurite outgrowth by promoting p-GSK3beta(Ser9). Anthocyanins 44-55 glycogen synthase kinase 3 beta Mus musculus 161-169 19416630-5 2009 For MAO A and B, IC(50) values in the low micromolar range were reached by anthocyanidins and anthocyanidin-3-glycosides, as opposed to values in the low millimolar range for phenolic acids. Anthocyanins 75-89 monoamine oxidase A Homo sapiens 4-9 19323506-1 2009 Two standardized anthocyanin-rich mixtures were investigated for their ability to inhibit the receptor tyrosine kinases (RTKs) EGFR, ErbB2, ErbB3, VEGFR-2, and VEGFR-3. Anthocyanins 17-28 epidermal growth factor receptor Homo sapiens 127-131 19323506-1 2009 Two standardized anthocyanin-rich mixtures were investigated for their ability to inhibit the receptor tyrosine kinases (RTKs) EGFR, ErbB2, ErbB3, VEGFR-2, and VEGFR-3. Anthocyanins 17-28 erb-b2 receptor tyrosine kinase 2 Homo sapiens 133-138 19323506-1 2009 Two standardized anthocyanin-rich mixtures were investigated for their ability to inhibit the receptor tyrosine kinases (RTKs) EGFR, ErbB2, ErbB3, VEGFR-2, and VEGFR-3. Anthocyanins 17-28 erb-b2 receptor tyrosine kinase 3 Homo sapiens 140-145 19323506-1 2009 Two standardized anthocyanin-rich mixtures were investigated for their ability to inhibit the receptor tyrosine kinases (RTKs) EGFR, ErbB2, ErbB3, VEGFR-2, and VEGFR-3. Anthocyanins 17-28 kinase insert domain receptor Homo sapiens 147-154 19323506-1 2009 Two standardized anthocyanin-rich mixtures were investigated for their ability to inhibit the receptor tyrosine kinases (RTKs) EGFR, ErbB2, ErbB3, VEGFR-2, and VEGFR-3. Anthocyanins 17-28 fms related receptor tyrosine kinase 4 Homo sapiens 160-167 19323506-4 2009 Anthocyanin-rich extracts completely abrogated VEGFR-3 phosphorylation at concentrations of >or=50 microg/mL. Anthocyanins 0-11 fms related receptor tyrosine kinase 4 Homo sapiens 47-54 19132683-7 2009 Throughout the observation period the upregulation of phenylalanine ammonia lyase, chalcone synthase, chalcone-flavanone isomerase (CHI) transcript expression levels well correlated with CHI protein amount and with the accumulation of anthocyanins. Anthocyanins 235-247 chalcone--flavonone isomerase 2 Vitis vinifera 102-130 19174152-2 2009 Here we report that Fyn kinase - one of the members of the nonreceptor protein tyrosine kinase family - is involved in TNF-alpha-induced COX-2 expression, and that delphinidin - a major anthocyanidin present in red wine and berries - inhibits these effects by directly inhibiting Fyn kinase activity. Anthocyanins 186-199 FYN proto-oncogene, Src family tyrosine kinase Homo sapiens 20-23 19287965-0 2009 Induction of apoptosis in human leukemia U937 cells by anthocyanins through down-regulation of Bcl-2 and activation of caspases. Anthocyanins 55-67 BCL2 apoptosis regulator Homo sapiens 95-100 19287965-0 2009 Induction of apoptosis in human leukemia U937 cells by anthocyanins through down-regulation of Bcl-2 and activation of caspases. Anthocyanins 55-67 caspase 8 Homo sapiens 119-127 19287965-5 2009 Apoptosis of U937 cells by anthocyanins was associated with modulation of expression of Bcl-2 and IAP family members. Anthocyanins 27-39 BCL2 apoptosis regulator Homo sapiens 88-93 19287965-6 2009 Consequently, anthocyanin treatment induced proteolytic activation of caspase-3, -8 and -9, and a concomitant degradation of poly(ADP-ribose) polymerase. Anthocyanins 14-25 caspase 3 Homo sapiens 70-90 19287965-7 2009 However, anthocyanin-induced growth inhibition and apoptosis were significantly attenuated in Bcl-2 overexpressing U937 cells. Anthocyanins 9-20 BCL2 apoptosis regulator Homo sapiens 94-99 19287965-9 2009 Taken together, these results show that Bcl-2 and caspases are key regulators of apoptosis in response to anthocyanins in human leukemia U937 cells. Anthocyanins 106-118 BCL2 apoptosis regulator Homo sapiens 40-45 19287965-9 2009 Taken together, these results show that Bcl-2 and caspases are key regulators of apoptosis in response to anthocyanins in human leukemia U937 cells. Anthocyanins 106-118 caspase 8 Homo sapiens 50-58 19082600-6 2009 PAL activities in the root tissues of young seedlings of another corn variety that lacked root anthocyanins (Indian Blue corn) were generally 30-50% lower than those of Japanese Striped corn seedlings at equivalent growth stages. Anthocyanins 95-107 phenylalanine ammonia-lyase Zea mays 0-3 19228327-2 2009 TTG1 (Transparent Testa Glabra 1), a WD-40 repeat protein, is involved in regulation of flavonoid/anthocyanin biosynthesis, seed coat (mucilage) development/pigmentation and trichome formation in leaves. Anthocyanins 98-109 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 0-4 19132683-7 2009 Throughout the observation period the upregulation of phenylalanine ammonia lyase, chalcone synthase, chalcone-flavanone isomerase (CHI) transcript expression levels well correlated with CHI protein amount and with the accumulation of anthocyanins. Anthocyanins 235-247 chalcone--flavonone isomerase 2 Vitis vinifera 132-135 18623129-0 2008 Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetables. Anthocyanins 84-97 epidermal growth factor receptor Homo sapiens 14-46 19349419-7 2009 Loss of SPPA appears to affect photoprotective mechanisms during high light acclimation: mutant plants maintained a higher level of non-photochemical quenching of Photosystem II chlorophyll (NPQ) than the wild type, while wild-type plants accumulated more anthocyanin than the mutants. Anthocyanins 256-267 signal peptide peptidase Arabidopsis thaliana 8-12 19291067-0 2009 Pigment loss in response to the environment: a new role for the WD/bHLH/MYB anthocyanin regulatory complex. Anthocyanins 76-87 MYB proto-oncogene, transcription factor Homo sapiens 72-75 19151225-9 2009 Taken together, these results indicate that an allelic rearrangement in the promoter of MYB10 has generated an autoregulatory locus, and this autoregulation is sufficient to account for the increase in MYB10 transcript levels and subsequent ectopic accumulation of anthocyanins throughout the plant. Anthocyanins 265-277 transcription factor MYB113-like Malus domestica 88-93 19151225-9 2009 Taken together, these results indicate that an allelic rearrangement in the promoter of MYB10 has generated an autoregulatory locus, and this autoregulation is sufficient to account for the increase in MYB10 transcript levels and subsequent ectopic accumulation of anthocyanins throughout the plant. Anthocyanins 265-277 transcription factor MYB113-like Malus domestica 202-207 18986148-0 2008 Anthocyanins from purple sweet potato Ipomoea batatas cultivar Ayamurasaki suppress the development of atherosclerotic lesions and both enhancements of oxidative stress and soluble vascular cell adhesion molecule-1 in apolipoprotein E-deficient mice. Anthocyanins 0-12 vascular cell adhesion molecule 1 Mus musculus 181-214 18766373-1 2008 The Arabidopsis PAP1 gene (At1g56650) encodes the MYB75 transcription factor, which has been demonstrated to essentially regulate the biosynthesis of anthocyanins. Anthocyanins 150-162 phosphatidic acid phosphatase 1 Arabidopsis thaliana 16-20 18766373-1 2008 The Arabidopsis PAP1 gene (At1g56650) encodes the MYB75 transcription factor, which has been demonstrated to essentially regulate the biosynthesis of anthocyanins. Anthocyanins 150-162 production of anthocyanin pigment 1 Arabidopsis thaliana 50-55 18766373-2 2008 Our previous study showed that ectopic expression of the PAP1 gene led to high pigmentation of anthocyanins in all tissues of transgenic tobacco plants. Anthocyanins 95-107 phosphatidic acid phosphatase 1 Arabidopsis thaliana 57-61 18766373-3 2008 In order to understand the mechanisms of how PAP1 regulates anthocyanin biosynthesis and what can regulate the function of PAP1, we have established PAP1 transgenic tobacco callus cultures. Anthocyanins 60-71 phosphatidic acid phosphatase 1 Arabidopsis thaliana 45-49 18766373-4 2008 Phenotypically different calli including anthocyanin-producing red and anthocyanin-free white calli lines were differentially induced from the same genotype of PAP1 transgenic plants. Anthocyanins 41-52 phosphatidic acid phosphatase 1 Arabidopsis thaliana 160-164 18766373-4 2008 Phenotypically different calli including anthocyanin-producing red and anthocyanin-free white calli lines were differentially induced from the same genotype of PAP1 transgenic plants. Anthocyanins 71-82 phosphatidic acid phosphatase 1 Arabidopsis thaliana 160-164 18766373-9 2008 We have demonstrated that dark, nitrogen nutrients, and auxin apparently affect the anthocyanin profiles in PAP1 transgenic callus cultures; and suggest that these cell cultures are an appropriate system to study the regulatory function of PAP1 on the anthocyanin biosynthesis at post-transcriptional level in vivo. Anthocyanins 84-95 phosphatidic acid phosphatase 1 Arabidopsis thaliana 108-112 18766373-9 2008 We have demonstrated that dark, nitrogen nutrients, and auxin apparently affect the anthocyanin profiles in PAP1 transgenic callus cultures; and suggest that these cell cultures are an appropriate system to study the regulatory function of PAP1 on the anthocyanin biosynthesis at post-transcriptional level in vivo. Anthocyanins 252-263 phosphatidic acid phosphatase 1 Arabidopsis thaliana 240-244 18495129-0 2009 Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation. Anthocyanins 0-11 CD40 molecule Homo sapiens 23-27 18495129-0 2009 Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation. Anthocyanins 0-11 CD40 molecule Homo sapiens 93-97 18495129-3 2009 Here we chose cultured human umbilical vein endothelial cells (HUVECs) to explore the influence of anthocyanin on CD40-mediated endothelial activation and apoptosis and the underlying mechanism. Anthocyanins 99-110 CD40 molecule Homo sapiens 114-118 18495129-6 2009 In addition, exposure to anthocyanins inhibits CD40-induced endothelial apoptosis. Anthocyanins 25-37 CD40 molecule Homo sapiens 47-51 18495129-7 2009 Anthocyanins also decreased activation of JNK and p38 induced by CD40. Anthocyanins 0-12 mitogen-activated protein kinase 14 Homo sapiens 50-53 18495129-7 2009 Anthocyanins also decreased activation of JNK and p38 induced by CD40. Anthocyanins 0-12 CD40 molecule Homo sapiens 65-69 18495129-8 2009 Collectively, our findings suggested that the inhibition of JNK and p38 activation interrupts CD40 induced endothelial cell activation and apoptosis, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin and its athero-protective function. Anthocyanins 243-254 mitogen-activated protein kinase 14 Homo sapiens 68-71 18495129-8 2009 Collectively, our findings suggested that the inhibition of JNK and p38 activation interrupts CD40 induced endothelial cell activation and apoptosis, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin and its athero-protective function. Anthocyanins 243-254 CD40 molecule Homo sapiens 94-98 19596700-5 2009 It was found that the F-box protein COI1 was required for JA-specific induced expression of the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT. Anthocyanins 103-114 RNI-like superfamily protein Arabidopsis thaliana 36-40 19596700-5 2009 It was found that the F-box protein COI1 was required for JA-specific induced expression of the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT. Anthocyanins 103-114 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 149-154 19596700-7 2009 It is speculated that COI1 regulates the expression of the transcription factors, including PAP1, PAP2, and GL3, which mediates the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT, thereby modulating JA-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 139-150 RNI-like superfamily protein Arabidopsis thaliana 22-26 19596700-7 2009 It is speculated that COI1 regulates the expression of the transcription factors, including PAP1, PAP2, and GL3, which mediates the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT, thereby modulating JA-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 139-150 phosphatidic acid phosphatase 1 Arabidopsis thaliana 92-96 19596700-7 2009 It is speculated that COI1 regulates the expression of the transcription factors, including PAP1, PAP2, and GL3, which mediates the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT, thereby modulating JA-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 139-150 Purple acid phosphatases superfamily protein Arabidopsis thaliana 98-102 19596700-7 2009 It is speculated that COI1 regulates the expression of the transcription factors, including PAP1, PAP2, and GL3, which mediates the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT, thereby modulating JA-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 139-150 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 108-111 19596700-7 2009 It is speculated that COI1 regulates the expression of the transcription factors, including PAP1, PAP2, and GL3, which mediates the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT, thereby modulating JA-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 139-150 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 185-190 19596700-7 2009 It is speculated that COI1 regulates the expression of the transcription factors, including PAP1, PAP2, and GL3, which mediates the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT, thereby modulating JA-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 222-233 RNI-like superfamily protein Arabidopsis thaliana 22-26 19596700-7 2009 It is speculated that COI1 regulates the expression of the transcription factors, including PAP1, PAP2, and GL3, which mediates the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT, thereby modulating JA-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 222-233 phosphatidic acid phosphatase 1 Arabidopsis thaliana 92-96 19596700-7 2009 It is speculated that COI1 regulates the expression of the transcription factors, including PAP1, PAP2, and GL3, which mediates the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT, thereby modulating JA-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 222-233 Purple acid phosphatases superfamily protein Arabidopsis thaliana 98-102 19596700-7 2009 It is speculated that COI1 regulates the expression of the transcription factors, including PAP1, PAP2, and GL3, which mediates the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT, thereby modulating JA-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 222-233 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 108-111 19596700-7 2009 It is speculated that COI1 regulates the expression of the transcription factors, including PAP1, PAP2, and GL3, which mediates the "late" anthocyanin biosynthetic genes DFR, LDOX, and UF3GT, thereby modulating JA-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 222-233 UDP-glucose:flavonoid 3-o-glucosyltransferase Arabidopsis thaliana 185-190 19140931-5 2009 It was found that plastid signals that depend on GUN1 can affect cotyledon opening and expansion, anthocyanin biosynthesis, and hypocotyl elongation. Anthocyanins 98-109 s uncoupled 1 Arabidopsis thaliana 49-53 19192188-1 2009 * High-temperature, low-light (HTLL) treatment of 35S:PAP1 Arabidopsis thaliana over-expressing the PAP1 (Production of Anthocyanin Pigment 1) gene results in reversible reduction of red colouration, suggesting the action of additional anthocyanin regulators. Anthocyanins 236-247 production of anthocyanin pigment 1 Arabidopsis thaliana 54-58 19192188-1 2009 * High-temperature, low-light (HTLL) treatment of 35S:PAP1 Arabidopsis thaliana over-expressing the PAP1 (Production of Anthocyanin Pigment 1) gene results in reversible reduction of red colouration, suggesting the action of additional anthocyanin regulators. Anthocyanins 236-247 production of anthocyanin pigment 1 Arabidopsis thaliana 100-104 19192188-1 2009 * High-temperature, low-light (HTLL) treatment of 35S:PAP1 Arabidopsis thaliana over-expressing the PAP1 (Production of Anthocyanin Pigment 1) gene results in reversible reduction of red colouration, suggesting the action of additional anthocyanin regulators. Anthocyanins 236-247 production of anthocyanin pigment 1 Arabidopsis thaliana 106-141 19192188-3 2009 * HTLL treatment of control and 35S:PAP1 A. thaliana resulted in a reversible reduction in the concentrations of major anthocyanins despite ongoing over-expression of the PAP1 MYB transcription factor. Anthocyanins 119-131 production of anthocyanin pigment 1 Arabidopsis thaliana 36-40 18998159-6 2009 Seedlings of an A. thaliana fls1 null mutant (fls1-2) show enhanced anthocyanin levels, drastic reduction in flavonol glycoside content and concomitant accumulation of glycosylated forms of dihydroflavonols, the substrate of the FLS reaction. Anthocyanins 68-79 flavonol synthase 1 Arabidopsis thaliana 28-32 18998159-6 2009 Seedlings of an A. thaliana fls1 null mutant (fls1-2) show enhanced anthocyanin levels, drastic reduction in flavonol glycoside content and concomitant accumulation of glycosylated forms of dihydroflavonols, the substrate of the FLS reaction. Anthocyanins 68-79 flavonol synthase 1 Arabidopsis thaliana 46-50 19053224-11 2008 These results suggested association between anthocyanin levels and CAT and a good correlation between antioxidant capacity and ascorbic acid in the human plasma after intake of BJs. Anthocyanins 44-55 catalase Homo sapiens 67-70 18643996-8 2008 Arabidopsis mutants lacking both TIP1;1 and TIP1;2 showed a minor increase in anthocyanin content, and a reduction in catalase activity, but showed no changes in water status. Anthocyanins 78-89 gamma tonoplast intrinsic protein Arabidopsis thaliana 33-39 18643996-8 2008 Arabidopsis mutants lacking both TIP1;1 and TIP1;2 showed a minor increase in anthocyanin content, and a reduction in catalase activity, but showed no changes in water status. Anthocyanins 78-89 tonoplast intrinsic protein 2 Arabidopsis thaliana 44-50 18953354-5 2008 In a pilot test, cancer-susceptible Trp53(-/-) mice fed a diet supplemented with the high-anthocyanin tomatoes showed a significant extension of life span. Anthocyanins 90-101 transformation related protein 53 Mus musculus 36-41 18655007-7 2008 Since the transport activity of the bilitranslocase in kidney basolateral membrane vesicles was competitively inhibited by malvidin 3-glucoside (K(i) = 4.8 +/- 0.2 microM), the anthocyanin uptake from blood into kidney tubular cells is likely to be mediated by the kidney isoform of this organic anion membrane transporter. Anthocyanins 177-188 ceruloplasmin Rattus norvegicus 36-51 18778065-0 2008 Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway. Anthocyanins 0-12 AKT serine/threonine kinase 1 Homo sapiens 210-213 18778065-5 2008 Anthocyanins inhibited UVB-induced cylooxygenase-2 (COX-2) and PGE 2 production through a nuclear factor-kappaB-dependent pathway and regulation of the PI3 kinase/Akt pathway activated by UVB in a human keratinocyte cell line, HaCaT. Anthocyanins 0-12 AKT serine/threonine kinase 1 Homo sapiens 163-166 19924259-5 2008 The anthocyanins inhibited topoisomerase relaxation activity only at high concentrations (> 50 muM) and we could find no evidence of topoisomerase I cleavable complex stabilization by these compounds. Anthocyanins 4-16 latexin Homo sapiens 98-101 18657430-1 2008 Flavanone 3beta-hydroxylase (F3H; EC 1.14.11.9) is a 2-oxoglutarate dependent dioxygenase that catalyzes the synthesis of dihydrokaempferol, the common precursor for three major classes of 3-hydroxy flavonoids, the flavonols, anthocyanins, and proanthocyanidins. Anthocyanins 226-238 flavanone 3-hydroxylase Arabidopsis thaliana 0-27 18657430-1 2008 Flavanone 3beta-hydroxylase (F3H; EC 1.14.11.9) is a 2-oxoglutarate dependent dioxygenase that catalyzes the synthesis of dihydrokaempferol, the common precursor for three major classes of 3-hydroxy flavonoids, the flavonols, anthocyanins, and proanthocyanidins. Anthocyanins 226-238 flavanone 3-hydroxylase Arabidopsis thaliana 29-32 18710248-4 2008 Anthocyanidins suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) mRNAs in TPA-stimulated HT-29 cells. Anthocyanins 0-14 prostaglandin-endoperoxide synthase 2 Homo sapiens 26-42 18710248-4 2008 Anthocyanidins suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) mRNAs in TPA-stimulated HT-29 cells. Anthocyanins 0-14 prostaglandin-endoperoxide synthase 2 Homo sapiens 44-49 18710248-4 2008 Anthocyanidins suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) mRNAs in TPA-stimulated HT-29 cells. Anthocyanins 0-14 nitric oxide synthase 2 Homo sapiens 55-86 18710248-4 2008 Anthocyanidins suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) mRNAs in TPA-stimulated HT-29 cells. Anthocyanins 0-14 nitric oxide synthase 2 Homo sapiens 88-92 18532977-0 2008 AtMYBL2, a protein with a single MYB domain, acts as a negative regulator of anthocyanin biosynthesis in Arabidopsis. Anthocyanins 77-88 MYB-like 2 Arabidopsis thaliana 0-7 18690680-3 2008 Bilberry extract (containing 42.04% anthocyanins) was oral administrated to mice at 50, 100, and 200 mg/(kg x day) for five days, which remarkably decreased plasma ALT level to 17.23 +/- 2.49 U/L at the dose of 200 mg/(kg x day) and thus alleviated stress-induced liver damage. Anthocyanins 36-48 glutamic pyruvic transaminase, soluble Mus musculus 164-167 18616524-4 2008 The major anthocyanin in PCC is cyanidin 3-O-beta-D-glucoside (C3-G). Anthocyanins 10-21 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 63-67 32688816-0 2008 Arabidopsis thaliana MYB75/PAP1 transcription factor induces anthocyanin production in transgenic tomato plants. Anthocyanins 61-72 production of anthocyanin pigment 1 Arabidopsis thaliana 21-26 32688816-0 2008 Arabidopsis thaliana MYB75/PAP1 transcription factor induces anthocyanin production in transgenic tomato plants. Anthocyanins 61-72 purple acid phosphatase 2 Solanum lycopersicum 27-31 32688816-5 2008 Transgenic tomato plants expressing AtMYB75 were characterised by a significantly higher anthocyanin production in leaves, stems, roots and flowers under normal growth conditions. Anthocyanins 89-100 production of anthocyanin pigment 1 Arabidopsis thaliana 36-43 32688816-9 2008 The expression of the tomato MYB-gene ANT1 (ANTHOCYANIN1), which had previously been identified as a transcriptional endogenous regulator of anthocyanin biosynthesis, was not altered. Anthocyanins 141-152 anthocyanin 1 Solanum lycopersicum 38-42 18532977-4 2008 We show here that an R3-MYB protein, AtMYBL2, acts as a transcriptional repressor and negatively regulates the biosynthesis of anthocyanin in Arabidopsis. Anthocyanins 127-138 MYB-like 2 Arabidopsis thaliana 37-44 18532977-5 2008 In an AtMYBL2 knockout line (mybl2), the expression of the DFR and TT8 genes was enhanced and resulted in the ectopic accumulation of anthocyanin, while ectopic expression of AtMYBL2 or of a chimeric repressor that is a dominant negative form of AtMYBL2 suppressed the expression of DFR and TT8, and the biosynthesis of anthocyanin. Anthocyanins 134-145 MYB-like 2 Arabidopsis thaliana 6-13 18532977-5 2008 In an AtMYBL2 knockout line (mybl2), the expression of the DFR and TT8 genes was enhanced and resulted in the ectopic accumulation of anthocyanin, while ectopic expression of AtMYBL2 or of a chimeric repressor that is a dominant negative form of AtMYBL2 suppressed the expression of DFR and TT8, and the biosynthesis of anthocyanin. Anthocyanins 134-145 MYB-like 2 Arabidopsis thaliana 29-34 18532977-5 2008 In an AtMYBL2 knockout line (mybl2), the expression of the DFR and TT8 genes was enhanced and resulted in the ectopic accumulation of anthocyanin, while ectopic expression of AtMYBL2 or of a chimeric repressor that is a dominant negative form of AtMYBL2 suppressed the expression of DFR and TT8, and the biosynthesis of anthocyanin. Anthocyanins 134-145 dihydroflavonol 4-reductase Arabidopsis thaliana 59-62 18532977-5 2008 In an AtMYBL2 knockout line (mybl2), the expression of the DFR and TT8 genes was enhanced and resulted in the ectopic accumulation of anthocyanin, while ectopic expression of AtMYBL2 or of a chimeric repressor that is a dominant negative form of AtMYBL2 suppressed the expression of DFR and TT8, and the biosynthesis of anthocyanin. Anthocyanins 134-145 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 67-70 18532977-5 2008 In an AtMYBL2 knockout line (mybl2), the expression of the DFR and TT8 genes was enhanced and resulted in the ectopic accumulation of anthocyanin, while ectopic expression of AtMYBL2 or of a chimeric repressor that is a dominant negative form of AtMYBL2 suppressed the expression of DFR and TT8, and the biosynthesis of anthocyanin. Anthocyanins 320-331 dihydroflavonol 4-reductase Arabidopsis thaliana 59-62 18532977-10 2008 The repression activity of AtMYBL2 appears to play a critical role in the regulation of anthocyanin biosynthesis. Anthocyanins 88-99 MYB-like 2 Arabidopsis thaliana 27-34 18532978-1 2008 SUMMARY: In Arabidopsis thaliana, several MYB and basic helix-loop-helix (BHLH) proteins form ternary complexes with TTG1 (WD-Repeats) and regulate the transcription of genes involved in anthocyanin and proanthocyanidin (PA) biosynthesis. Anthocyanins 187-198 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 117-121 18532978-6 2008 The loss of MYBL2 activity in the seedlings of two independent T-DNA insertion mutants led to a dramatic increase in the accumulation of anthocyanin. Anthocyanins 137-148 MYB-like 2 Arabidopsis thaliana 12-17 18594508-9 2008 Using both tests for positive selection and assays of enzyme function, we then demonstrate that adaptive evolutionary change in a duplicated gene of the anthocyanin biosynthetic pathway in morning glories (Ipomoea) is best interpreted as EAC. Anthocyanins 153-164 CYLD lysine 63 deubiquitinase Homo sapiens 238-241 18796637-7 2008 Furthermore, sth3 suppresses the cop1 hypocotyl phenotype in the dark as well as the anthocyanin accumulation in the light. Anthocyanins 85-96 light-regulated zinc finger protein 1 Arabidopsis thaliana 13-17 18539781-0 2008 The transcription factor VvMYB5b contributes to the regulation of anthocyanin and proanthocyanidin biosynthesis in developing grape berries. Anthocyanins 66-77 MYB5b Vitis vinifera 25-32 18645237-1 2008 Dihydroflavonol 4-reductase (DFR) is a key enzyme of the flavonoid biosynthesis pathway which catalyses the NADPH-dependent reduction of 2R,3R-trans-dihydroflavonols to leucoanthocyanidins. Anthocyanins 169-188 dihydroflavonol 4-reductase Vitis vinifera 0-27 18645237-1 2008 Dihydroflavonol 4-reductase (DFR) is a key enzyme of the flavonoid biosynthesis pathway which catalyses the NADPH-dependent reduction of 2R,3R-trans-dihydroflavonols to leucoanthocyanidins. Anthocyanins 169-188 dihydroflavonol 4-reductase Vitis vinifera 29-32 18539781-6 2008 Overexpression of VvMYB5b in tobacco (Nicotiana tabacum) leads to an up-regulation of genes encoding enzymes of the flavonoid pathway and results in the accumulation of anthocyanin- and proanthocyanidin-derived compounds. Anthocyanins 169-180 MYB5b Vitis vinifera 18-25 18539781-7 2008 The ability of VvMYB5b to regulate particularly the anthocyanin and the proanthocyanidin pathways is discussed in relation to other recently characterized MYB transcription factors in grapevine. Anthocyanins 52-63 MYB5b Vitis vinifera 15-22 18539781-7 2008 The ability of VvMYB5b to regulate particularly the anthocyanin and the proanthocyanidin pathways is discussed in relation to other recently characterized MYB transcription factors in grapevine. Anthocyanins 52-63 uncharacterized protein LOC107775040 Nicotiana tabacum 17-20 18601751-3 2008 While much is known about the families of transcription factors that regulate gene expression in plants, there are few well characterised cis-regulatory motifs.In Arabidopsis, over-expression of the MYB transcription factor PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT 1) leads to transgenic plants with elevated anthocyanin levels due to the co-ordinated up-regulation of genes in the anthocyanin biosynthetic pathway. Anthocyanins 308-319 production of anthocyanin pigment 1 Arabidopsis thaliana 224-228 18601751-3 2008 While much is known about the families of transcription factors that regulate gene expression in plants, there are few well characterised cis-regulatory motifs.In Arabidopsis, over-expression of the MYB transcription factor PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT 1) leads to transgenic plants with elevated anthocyanin levels due to the co-ordinated up-regulation of genes in the anthocyanin biosynthetic pathway. Anthocyanins 308-319 production of anthocyanin pigment 1 Arabidopsis thaliana 230-265 18601751-3 2008 While much is known about the families of transcription factors that regulate gene expression in plants, there are few well characterised cis-regulatory motifs.In Arabidopsis, over-expression of the MYB transcription factor PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT 1) leads to transgenic plants with elevated anthocyanin levels due to the co-ordinated up-regulation of genes in the anthocyanin biosynthetic pathway. Anthocyanins 381-392 production of anthocyanin pigment 1 Arabidopsis thaliana 224-228 18601751-3 2008 While much is known about the families of transcription factors that regulate gene expression in plants, there are few well characterised cis-regulatory motifs.In Arabidopsis, over-expression of the MYB transcription factor PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT 1) leads to transgenic plants with elevated anthocyanin levels due to the co-ordinated up-regulation of genes in the anthocyanin biosynthetic pathway. Anthocyanins 381-392 production of anthocyanin pigment 1 Arabidopsis thaliana 230-265 18424626-1 2008 Treatment of Arabidopsis (Arabidopsis thaliana) alternative oxidase1a (aox1a) mutant plants with moderate light under drought conditions resulted in a phenotypic difference compared with ecotype Columbia (Col-0), as evidenced by a 10-fold increase in the accumulation of anthocyanins in leaves, alterations in photosynthetic efficiency, and increased superoxide radical and reduced root growth at the early stages of seedling growth. Anthocyanins 271-283 alternative oxidase 1A Arabidopsis thaliana 48-69 18549488-11 2008 The mRNA levels of phenylalanine ammonia-lyase (PAL), the enzyme catalysing the first step of anthocyanin synthesis, were decreased. Anthocyanins 94-105 phenylalanine ammonia-lyase Solanum tuberosum 19-46 18549488-11 2008 The mRNA levels of phenylalanine ammonia-lyase (PAL), the enzyme catalysing the first step of anthocyanin synthesis, were decreased. Anthocyanins 94-105 phenylalanine ammonia-lyase Solanum tuberosum 48-51 18549488-14 2008 The level of PAL mRNA and consequently the amount of anthocyanin pigments are reduced in the CgSDelta90 transgenic tubers suggesting that methionine synthesis and production of anthocyanins is linked. Anthocyanins 177-189 phenylalanine ammonia-lyase Solanum tuberosum 13-16 18317777-0 2008 Arabidopsis R2R3-MYB transcription factor AtMYB60 functions as a transcriptional repressor of anthocyanin biosynthesis in lettuce (Lactuca sativa). Anthocyanins 94-105 myb domain protein 60 Arabidopsis thaliana 42-49 18317777-4 2008 We found that one member of this protein family, AtMYB60, inhibits anthocyanin biosynthesis in the lettuce plant. Anthocyanins 67-78 myb domain protein 60 Arabidopsis thaliana 49-56 18317777-6 2008 However, the production and accumulation of anthocyanin pigments in AtMYB60-overexpressing lettuce was inhibited. Anthocyanins 44-55 myb domain protein 60 Arabidopsis thaliana 68-75 18317777-8 2008 The correlation between the overexpression of AtMYB60 and the inhibition of anthocyanin accumulation suggests that the transcription factorAtMYB60 controls anthocyanin biosynthesis in the lettuce leaf. Anthocyanins 76-87 myb domain protein 60 Arabidopsis thaliana 46-53 18317777-8 2008 The correlation between the overexpression of AtMYB60 and the inhibition of anthocyanin accumulation suggests that the transcription factorAtMYB60 controls anthocyanin biosynthesis in the lettuce leaf. Anthocyanins 156-167 myb domain protein 60 Arabidopsis thaliana 46-53 18424626-1 2008 Treatment of Arabidopsis (Arabidopsis thaliana) alternative oxidase1a (aox1a) mutant plants with moderate light under drought conditions resulted in a phenotypic difference compared with ecotype Columbia (Col-0), as evidenced by a 10-fold increase in the accumulation of anthocyanins in leaves, alterations in photosynthetic efficiency, and increased superoxide radical and reduced root growth at the early stages of seedling growth. Anthocyanins 271-283 alternative oxidase 1A Arabidopsis thaliana 71-76 17766004-1 2008 In this work we analysed, at the transcript level, the response of Arabidopsis anthocyanin regulatory genes of the MYB (PAP1 and PAP2), bHLH (TT8, EGL3 and GL3) and WD40 (TTG1) families to white light in seedlings and to different light qualities in rosette leaves. Anthocyanins 79-90 phosphatidic acid phosphatase 1 Arabidopsis thaliana 120-124 17766004-1 2008 In this work we analysed, at the transcript level, the response of Arabidopsis anthocyanin regulatory genes of the MYB (PAP1 and PAP2), bHLH (TT8, EGL3 and GL3) and WD40 (TTG1) families to white light in seedlings and to different light qualities in rosette leaves. Anthocyanins 79-90 Purple acid phosphatases superfamily protein Arabidopsis thaliana 129-133 17766004-1 2008 In this work we analysed, at the transcript level, the response of Arabidopsis anthocyanin regulatory genes of the MYB (PAP1 and PAP2), bHLH (TT8, EGL3 and GL3) and WD40 (TTG1) families to white light in seedlings and to different light qualities in rosette leaves. Anthocyanins 79-90 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 142-145 17766004-1 2008 In this work we analysed, at the transcript level, the response of Arabidopsis anthocyanin regulatory genes of the MYB (PAP1 and PAP2), bHLH (TT8, EGL3 and GL3) and WD40 (TTG1) families to white light in seedlings and to different light qualities in rosette leaves. Anthocyanins 79-90 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 147-151 17766004-1 2008 In this work we analysed, at the transcript level, the response of Arabidopsis anthocyanin regulatory genes of the MYB (PAP1 and PAP2), bHLH (TT8, EGL3 and GL3) and WD40 (TTG1) families to white light in seedlings and to different light qualities in rosette leaves. Anthocyanins 79-90 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 148-151 17766004-1 2008 In this work we analysed, at the transcript level, the response of Arabidopsis anthocyanin regulatory genes of the MYB (PAP1 and PAP2), bHLH (TT8, EGL3 and GL3) and WD40 (TTG1) families to white light in seedlings and to different light qualities in rosette leaves. Anthocyanins 79-90 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 171-175 17766004-3 2008 In particular, the kinetics of PAP1 expression preceded those of PAP2 and all of the structural genes (CHS, DFR, F3H, LDOX), consistent with the hypothesis that it has a key role in light induction of anthocyanin biosynthesis. Anthocyanins 201-212 phosphatidic acid phosphatase 1 Arabidopsis thaliana 31-35 17766004-6 2008 Experiments with transgenic lines over-expressing the MYB factors show that PAP1, but not PAP2, strongly stimulates expression of the anthocyanin structural gene encoding dihydroflavonol reductase, but neither factor affected expression of the early flavonoid biosynthesis gene encoding chalcone synthase. Anthocyanins 134-145 phosphatidic acid phosphatase 1 Arabidopsis thaliana 76-80 17766004-7 2008 Consistent with these findings, PAP1, but not PAP2, stimulated light induction of anthocyanin biosynthesis in seedlings. Anthocyanins 82-93 phosphatidic acid phosphatase 1 Arabidopsis thaliana 32-36 18343361-1 2008 A T-DNA insertion mutant of FUSCA3 (fus3-T) in Arabidopsis thaliana exhibits several of the expected deleterious effects on seed development, but not the formation of brown seeds, a colouration which results from the accumulation of large amounts of anthocyanin. Anthocyanins 250-261 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 28-34 18339683-0 2008 Delphinidin, a dietary anthocyanidin, inhibits platelet-derived growth factor ligand/receptor (PDGF/PDGFR) signaling. Anthocyanins 23-36 platelet derived growth factor receptor, beta polypeptide Mus musculus 100-105 18343361-1 2008 A T-DNA insertion mutant of FUSCA3 (fus3-T) in Arabidopsis thaliana exhibits several of the expected deleterious effects on seed development, but not the formation of brown seeds, a colouration which results from the accumulation of large amounts of anthocyanin. Anthocyanins 250-261 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 36-40 18346094-4 2008 In this study, the Production of Anthocyanin Pigment1 (Pap1) Myb transcription factor from Arabidopsis thaliana, known to regulate the production of non-volatile phenylpropanoids, including anthocyanins, was stably introduced into Petunia hybrida. Anthocyanins 190-202 production of anthocyanin pigment 1 Arabidopsis thaliana 19-53 18346094-4 2008 In this study, the Production of Anthocyanin Pigment1 (Pap1) Myb transcription factor from Arabidopsis thaliana, known to regulate the production of non-volatile phenylpropanoids, including anthocyanins, was stably introduced into Petunia hybrida. Anthocyanins 190-202 production of anthocyanin pigment 1 Arabidopsis thaliana 55-59 18356331-9 2008 Total flavonoid and also individual flavonol, anthocyanidin, and isoflavone intakes were inversely associated with serum CRP concentration after adjusting for the covariates (P < 0.05). Anthocyanins 46-59 C-reactive protein Homo sapiens 121-124 18359840-0 2008 Arabidopsis sucrose transporter AtSUC1 is important for pollen germination and sucrose-induced anthocyanin accumulation. Anthocyanins 95-106 sucrose-proton symporter 1 Arabidopsis thaliana 32-38 18359840-5 2008 AtSUC1 is important for sucrose-dependent signaling leading to anthocyanin accumulation in seedlings. Anthocyanins 63-74 sucrose-proton symporter 1 Arabidopsis thaliana 0-6 18359840-6 2008 suc1 mutants accumulated less anthocyanins in response to exogenous sucrose or maltose and microarray analysis revealed reduced expression of many genes important for anthocyanin biosynthesis. Anthocyanins 30-42 sucrose-proton symporter 1 Arabidopsis thaliana 0-4 18359840-6 2008 suc1 mutants accumulated less anthocyanins in response to exogenous sucrose or maltose and microarray analysis revealed reduced expression of many genes important for anthocyanin biosynthesis. Anthocyanins 30-41 sucrose-proton symporter 1 Arabidopsis thaliana 0-4 18287490-5 2008 Overexpression of STF1 in the hy5 mutant of Arabidopsis restored wild-type photomorphogenic and root development phenotypes of short hypocotyl, accumulation of chlorophyll, and root gravitropism with partial restoration of anthocyanin accumulation. Anthocyanins 223-234 phosphoglucomutase Arabidopsis thaliana 18-22 18182030-5 2008 Anthocyanin content is significantly diminished in lzf1 under far red, which is the most efficient light for the induction of LZF1. Anthocyanins 0-11 light-regulated zinc finger protein 1 Arabidopsis thaliana 51-55 18182030-5 2008 Anthocyanin content is significantly diminished in lzf1 under far red, which is the most efficient light for the induction of LZF1. Anthocyanins 0-11 light-regulated zinc finger protein 1 Arabidopsis thaliana 126-130 18182030-6 2008 The expression of PAP1/MYB75 is elevated in plants overexpressing LZF1, which leads to the hyperaccumulation of anthocyanin in transgenic Arabidopsis. Anthocyanins 112-123 phosphatidic acid phosphatase 1 Arabidopsis thaliana 18-22 18182030-6 2008 The expression of PAP1/MYB75 is elevated in plants overexpressing LZF1, which leads to the hyperaccumulation of anthocyanin in transgenic Arabidopsis. Anthocyanins 112-123 production of anthocyanin pigment 1 Arabidopsis thaliana 23-28 18182030-6 2008 The expression of PAP1/MYB75 is elevated in plants overexpressing LZF1, which leads to the hyperaccumulation of anthocyanin in transgenic Arabidopsis. Anthocyanins 112-123 light-regulated zinc finger protein 1 Arabidopsis thaliana 66-70 18182030-9 2008 In the absence of HY5, mutation of LZF1 leads to further reduced light sensitivity for light-regulated inhibition of hypocotyl elongation and anthocyanin and chlorophyll accumulation. Anthocyanins 142-153 light-regulated zinc finger protein 1 Arabidopsis thaliana 35-39 18321380-3 2008 RESULTS: Transgenic plants over-expressing dihydroflavonol reductase (DFR) were subsequently transformed with the cDNA coding for the glycosyltransferase (UGT) of Solanum sogarandinum in order to obtain plants with a high anthocyanin content without reducing tuber yield and quality. Anthocyanins 222-233 hydroquinone glucosyltransferase-like Solanum tuberosum 134-153 18321380-4 2008 Based on enzyme studies, the recombinant UGT is a 7-O-glycosyltransferase whose natural substrates include both anthocyanidins and flavonols such as kaempferol and quercetin. Anthocyanins 112-126 hydroquinone glucosyltransferase-like Solanum tuberosum 54-73 18321380-8 2008 CONCLUSION: In plants over-expressing both the transgene for DFR and the transgene for UGT, the synthesis of phenolic acids was diverted away from the anthocyanin branch. Anthocyanins 151-162 dihydroflavonol-4-reductase Solanum tuberosum 61-64 18047557-5 2008 Our results show that both the barley and Arabidopsis FUS3 genes maintain a conserved functionality for the regulation of SSP genes and anthocyanin biosynthesis in these two distantly related phylogenetic groups. Anthocyanins 136-147 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 54-58 18036197-0 2008 Regulation of the anthocyanin biosynthetic pathway by the TTG1/bHLH/Myb transcriptional complex in Arabidopsis seedlings. Anthocyanins 18-29 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 58-62 18036197-5 2008 Also, plants harboring an RNAi construct targeting PAP1 and three Myb candidates (PAP2, Myb113 and Myb114) showed downregulated Myb gene expression and obvious anthocyanin deficiencies. Anthocyanins 160-171 phosphatidic acid phosphatase 1 Arabidopsis thaliana 51-55 18036197-5 2008 Also, plants harboring an RNAi construct targeting PAP1 and three Myb candidates (PAP2, Myb113 and Myb114) showed downregulated Myb gene expression and obvious anthocyanin deficiencies. Anthocyanins 160-171 Purple acid phosphatases superfamily protein Arabidopsis thaliana 82-86 18036197-5 2008 Also, plants harboring an RNAi construct targeting PAP1 and three Myb candidates (PAP2, Myb113 and Myb114) showed downregulated Myb gene expression and obvious anthocyanin deficiencies. Anthocyanins 160-171 myb domain protein 113 Arabidopsis thaliana 88-94 18036197-5 2008 Also, plants harboring an RNAi construct targeting PAP1 and three Myb candidates (PAP2, Myb113 and Myb114) showed downregulated Myb gene expression and obvious anthocyanin deficiencies. Anthocyanins 160-171 myb domain protein 114 Arabidopsis thaliana 99-105 18036197-6 2008 Correlated with these anthocyanin deficiencies is downregulation of the same late anthocyanin structural genes that are downregulated in ttg1 and bHLH anthocyanin mutants. Anthocyanins 22-33 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 137-141 18036197-6 2008 Correlated with these anthocyanin deficiencies is downregulation of the same late anthocyanin structural genes that are downregulated in ttg1 and bHLH anthocyanin mutants. Anthocyanins 82-93 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 137-141 18036197-6 2008 Correlated with these anthocyanin deficiencies is downregulation of the same late anthocyanin structural genes that are downregulated in ttg1 and bHLH anthocyanin mutants. Anthocyanins 82-93 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 137-141 18047557-6 2008 Complementation of the loss-of-function mutant fus3 in Arabidopsis by the barley HvFus3 gene resulted in restored transcription from the At2S3 gene promoter and normal accumulation of anthocyanins in the seed. Anthocyanins 184-196 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 47-51 18167546-6 2008 Furthermore, the enhanced sensitivity of osu1-1 to high C/low N with respect to anthocyanin accumulation but not root growth inhibition can be suppressed by co-suppression of MYB75, indicating that MYB75 acts downstream of OSU1 in the high C/low N imbalance response. Anthocyanins 80-91 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Arabidopsis thaliana 41-47 18167546-6 2008 Furthermore, the enhanced sensitivity of osu1-1 to high C/low N with respect to anthocyanin accumulation but not root growth inhibition can be suppressed by co-suppression of MYB75, indicating that MYB75 acts downstream of OSU1 in the high C/low N imbalance response. Anthocyanins 80-91 production of anthocyanin pigment 1 Arabidopsis thaliana 198-203 17973529-0 2007 TFA-mediated tandem Friedel-Crafts alkylation/cyclization/hydrogen transfer process for the synthesis of flavylium compounds. Anthocyanins 105-114 coagulation factor III, tissue factor Homo sapiens 0-3 18167546-4 2008 Using the cotyledon anthocyanin accumulation and root growth inhibition assays, we show that the osu1 mutants are more sensitive than wild-type to both of the imbalanced C/N conditions, high C/low N and low C/high N. However, under the balanced C/N conditions (low C/low N or high C/high N), the osu1 mutants have similar anthocyanin levels and root lengths as wild-type. Anthocyanins 20-31 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Arabidopsis thaliana 97-101 18167546-4 2008 Using the cotyledon anthocyanin accumulation and root growth inhibition assays, we show that the osu1 mutants are more sensitive than wild-type to both of the imbalanced C/N conditions, high C/low N and low C/high N. However, under the balanced C/N conditions (low C/low N or high C/high N), the osu1 mutants have similar anthocyanin levels and root lengths as wild-type. Anthocyanins 322-333 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Arabidopsis thaliana 97-101 18552353-0 2008 Adaptation of Arabidopsis to nitrogen limitation involves induction of anthocyanin synthesis which is controlled by the NLA gene. Anthocyanins 71-82 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 120-123 18552353-4 2008 Grown with limiting N, the nla mutant could not accumulate anthocyanins and instead produced an N limitation-induced early senescence phenotype. Anthocyanins 59-71 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 27-30 18552353-5 2008 In contrast, when supplied with limiting N and limiting phosphorus (Pi), the nla mutants accumulated abundant anthocyanins and did not show the N limitation-induced early senescence phenotype. Anthocyanins 110-122 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 77-80 18552353-6 2008 These results support the hypothesis that Arabidopsis has a specific pathway to control N limitation-induced anthocyanin synthesis, and the nla mutation disrupts this pathway. Anthocyanins 109-120 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 140-143 18552353-8 2008 Therefore, Pi limitation induced the nla mutant to accumulate anthocyanins under N limitation and allowed this mutant to adapt to N limitation. Anthocyanins 62-74 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 37-40 18552353-9 2008 Under N limitation, the nla mutant had a significantly down-regulated expression of many genes functioning in anthocyanin synthesis, and an enhanced expression of genes involved in lignin production. Anthocyanins 110-121 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 24-27 18552353-10 2008 Correspondingly, the nla mutant grown with limiting N showed a significantly lower production of anthocyanins (particularly cyanidins) and an increase in lignin contents compared with wild-type plants. Anthocyanins 97-109 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 21-24 18552353-11 2008 These data suggest that NLA controls Arabidopsis adaptability to N limitation by channelling the phenylpropanoid metabolic flux to the induced anthocyanin synthesis, which is important for Arabidopsis to adapt to N limitation. Anthocyanins 143-154 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 24-27 17570561-3 2008 We isolated partial cDNAs that codified for enzymes implicated in the anthocyanin biosynthesis such as l-phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS), and an antioxidant enzyme such as ascorbate peroxidase (APX). Anthocyanins 70-81 type III polyketide synthase B Vitis vinifera 143-160 17570561-3 2008 We isolated partial cDNAs that codified for enzymes implicated in the anthocyanin biosynthesis such as l-phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS), and an antioxidant enzyme such as ascorbate peroxidase (APX). Anthocyanins 70-81 cytosolic ascorbate peroxidase Vitis vinifera 224-227 17869225-3 2007 In this study, we have demonstrated that anthocyanin (cyanidin 3-glucoside; C3G) which is a pigment widespread in the plant kingdom, ameliorates hyperglycemia and insulin sensitivity due to the reduction of retinol binding protein 4 (RBP4) expression in type 2 diabetic mice. Anthocyanins 41-52 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 76-79 17869225-3 2007 In this study, we have demonstrated that anthocyanin (cyanidin 3-glucoside; C3G) which is a pigment widespread in the plant kingdom, ameliorates hyperglycemia and insulin sensitivity due to the reduction of retinol binding protein 4 (RBP4) expression in type 2 diabetic mice. Anthocyanins 41-52 retinol binding protein 4, plasma Mus musculus 207-232 17869225-3 2007 In this study, we have demonstrated that anthocyanin (cyanidin 3-glucoside; C3G) which is a pigment widespread in the plant kingdom, ameliorates hyperglycemia and insulin sensitivity due to the reduction of retinol binding protein 4 (RBP4) expression in type 2 diabetic mice. Anthocyanins 41-52 retinol binding protein 4, plasma Mus musculus 234-238 17694320-6 2007 Expression profiling revealed that the increased anthocyanin accumulation resulted from earlier and greater expression of the genes controlling flux through the anthocyanin biosynthetic pathway, including F3H, DFR, UFGT and GST. Anthocyanins 49-60 naringenin,2-oxoglutarate 3-dioxygenase Vitis vinifera 205-208 17694320-6 2007 Expression profiling revealed that the increased anthocyanin accumulation resulted from earlier and greater expression of the genes controlling flux through the anthocyanin biosynthetic pathway, including F3H, DFR, UFGT and GST. Anthocyanins 49-60 dihydroflavonol 4-reductase Vitis vinifera 210-213 17694320-6 2007 Expression profiling revealed that the increased anthocyanin accumulation resulted from earlier and greater expression of the genes controlling flux through the anthocyanin biosynthetic pathway, including F3H, DFR, UFGT and GST. Anthocyanins 161-172 naringenin,2-oxoglutarate 3-dioxygenase Vitis vinifera 205-208 17694320-6 2007 Expression profiling revealed that the increased anthocyanin accumulation resulted from earlier and greater expression of the genes controlling flux through the anthocyanin biosynthetic pathway, including F3H, DFR, UFGT and GST. Anthocyanins 161-172 dihydroflavonol 4-reductase Vitis vinifera 210-213 18836188-6 2008 Transcriptional profiling of these candidate GST genes and key anthocyanin biosynthetic pathway genes (PAL, CHS, DFR, and UFGT) in cell suspensions and grape berries against anthocyanin accumulation demonstrated strong positive correlation with two sequences, VvGST1 and VvGST4, respectively. Anthocyanins 63-74 glutathione S-transferase Vitis vinifera 260-266 18836188-6 2008 Transcriptional profiling of these candidate GST genes and key anthocyanin biosynthetic pathway genes (PAL, CHS, DFR, and UFGT) in cell suspensions and grape berries against anthocyanin accumulation demonstrated strong positive correlation with two sequences, VvGST1 and VvGST4, respectively. Anthocyanins 63-74 glutathione S-transferase Vitis vinifera 271-277 18836188-6 2008 Transcriptional profiling of these candidate GST genes and key anthocyanin biosynthetic pathway genes (PAL, CHS, DFR, and UFGT) in cell suspensions and grape berries against anthocyanin accumulation demonstrated strong positive correlation with two sequences, VvGST1 and VvGST4, respectively. Anthocyanins 174-185 dihydroflavonol 4-reductase Vitis vinifera 113-116 18836188-6 2008 Transcriptional profiling of these candidate GST genes and key anthocyanin biosynthetic pathway genes (PAL, CHS, DFR, and UFGT) in cell suspensions and grape berries against anthocyanin accumulation demonstrated strong positive correlation with two sequences, VvGST1 and VvGST4, respectively. Anthocyanins 174-185 glutathione S-transferase Vitis vinifera 260-266 18836188-6 2008 Transcriptional profiling of these candidate GST genes and key anthocyanin biosynthetic pathway genes (PAL, CHS, DFR, and UFGT) in cell suspensions and grape berries against anthocyanin accumulation demonstrated strong positive correlation with two sequences, VvGST1 and VvGST4, respectively. Anthocyanins 174-185 glutathione S-transferase Vitis vinifera 271-277 18836188-7 2008 The ability of VvGST1 and VvGST4 to transport anthocyanins was confirmed in the heterologous maize bronze-2 complementation model, providing further evidence for their function as anthocyanin transport proteins in grape cells. Anthocyanins 46-58 glutathione S-transferase Vitis vinifera 15-21 18836188-7 2008 The ability of VvGST1 and VvGST4 to transport anthocyanins was confirmed in the heterologous maize bronze-2 complementation model, providing further evidence for their function as anthocyanin transport proteins in grape cells. Anthocyanins 46-58 glutathione S-transferase Vitis vinifera 26-32 18836188-7 2008 The ability of VvGST1 and VvGST4 to transport anthocyanins was confirmed in the heterologous maize bronze-2 complementation model, providing further evidence for their function as anthocyanin transport proteins in grape cells. Anthocyanins 46-57 glutathione S-transferase Vitis vinifera 15-21 18836188-7 2008 The ability of VvGST1 and VvGST4 to transport anthocyanins was confirmed in the heterologous maize bronze-2 complementation model, providing further evidence for their function as anthocyanin transport proteins in grape cells. Anthocyanins 46-57 glutathione S-transferase Vitis vinifera 26-32 18537890-4 2008 The expression pattern of 14 genes involved in the anthocyanin biosynthetic pathway, including two transcription factors (PAP1, PAP2), was analysed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in Arabidopsis seedlings treated with sucrose and plant hormones. Anthocyanins 51-62 phosphatidic acid phosphatase 1 Arabidopsis thaliana 122-126 18537890-4 2008 The expression pattern of 14 genes involved in the anthocyanin biosynthetic pathway, including two transcription factors (PAP1, PAP2), was analysed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in Arabidopsis seedlings treated with sucrose and plant hormones. Anthocyanins 51-62 Purple acid phosphatases superfamily protein Arabidopsis thaliana 128-132 18537890-9 2008 Sucrose induction of anthocyanin genes required the COI1 gene, but not JAR1, which suggests a possible convergence of the jasmonate- and sucrose-signalling pathways. Anthocyanins 21-32 RNI-like superfamily protein Arabidopsis thaliana 52-56 17973529-1 2007 The tandem reaction of phenols and chalcones in refluxing TFA gave the flavylium species of 2-hydroxy-2-phenyl-2H-chromenes in moderate to good isolated yields. Anthocyanins 71-80 coagulation factor III, tissue factor Homo sapiens 58-61 18003924-10 2007 Anthocyanin production in response to blue light was strongly stimulated by nuclear cry1 and, to a lesser extent, by cytoplasmic cry1. Anthocyanins 0-11 cryptochrome 1 Arabidopsis thaliana 84-88 18003924-10 2007 Anthocyanin production in response to blue light was strongly stimulated by nuclear cry1 and, to a lesser extent, by cytoplasmic cry1. Anthocyanins 0-11 cryptochrome 1 Arabidopsis thaliana 129-133 17935293-5 2007 Our results obtained in rat liver Clone 9 cells showed that treatment of anthocyanins leads to positive effects on elevating the antioxidant capacity, including activated expression of glutathione-related enzymes (glutathione reductase, glutathione peroxidase, and glutathione S-transferase) and recruited GSH content. Anthocyanins 73-85 glutathione-disulfide reductase Rattus norvegicus 214-235 17935293-5 2007 Our results obtained in rat liver Clone 9 cells showed that treatment of anthocyanins leads to positive effects on elevating the antioxidant capacity, including activated expression of glutathione-related enzymes (glutathione reductase, glutathione peroxidase, and glutathione S-transferase) and recruited GSH content. Anthocyanins 73-85 hematopoietic prostaglandin D synthase Rattus norvegicus 265-290 17935293-6 2007 In addition, the activity of NAD(P)H: quinone oxidoreductase (NQO1) was also promoted under the treatment of anthocyanin. Anthocyanins 109-120 crystallin zeta Rattus norvegicus 38-60 17935293-6 2007 In addition, the activity of NAD(P)H: quinone oxidoreductase (NQO1) was also promoted under the treatment of anthocyanin. Anthocyanins 109-120 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 62-66 17935293-8 2007 The capacity for induction of luciferase expression by anthocyanins in cells transfected with rat nqo1-promoter constructed plasmid was further investigated; we found that the molecular mechanism is related to the activation of antioxidant response element (ARE) upstream of genes that are involved in antioxidation and detoxification. Anthocyanins 55-67 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 98-102 17764520-4 2007 It has been demonstrated that the yellow seed coat phenotype of various cultivated soybean lines that lack anthocyanin pigmentation is induced by natural degradation of chalcone synthase (CHS) mRNA. Anthocyanins 107-118 chalcone synthase 3 Glycine max 188-191 17885080-6 2007 Antisense down-regulation of ANS in M. truncatula resulted in reduced anthocyanin and PA levels, but had no impact on flavonol levels. Anthocyanins 70-81 leucoanthocyanidin dioxygenase-like Nicotiana tabacum 29-32 17991994-3 2007 Four independent Mu-induced mutable alleles of the anthocyanin pigment pathway Bronze2 (Bz2) locus have been sequenced; bz2-mu1, bz2-mu2, and bz2-mu3 contain Mu1 element insertions while bz2-mu4 contains a MuDR insertion. Anthocyanins 51-62 glutathione S-transferase Zea mays 79-86 17965270-7 2007 The sth2 mutant, like hy5, shows an enhanced number of lateral roots and accumulates less anthocyanin. Anthocyanins 90-101 salt tolerance homolog2 Arabidopsis thaliana 4-8 17965270-7 2007 The sth2 mutant, like hy5, shows an enhanced number of lateral roots and accumulates less anthocyanin. Anthocyanins 90-101 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 22-25 17965270-9 2007 Furthermore, besides partially suppressing the hypocotyl phenotype of dark-grown cop1 alleles, sth2 also suppresses the reduced number of lateral roots and high anthocyanin levels in light-grown cop1 alleles. Anthocyanins 161-172 salt tolerance homolog2 Arabidopsis thaliana 95-99 17965270-9 2007 Furthermore, besides partially suppressing the hypocotyl phenotype of dark-grown cop1 alleles, sth2 also suppresses the reduced number of lateral roots and high anthocyanin levels in light-grown cop1 alleles. Anthocyanins 161-172 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 195-199 17556505-5 2007 When the two signals are coactivated in cells (i.e. tylapx/apx1), a new response is detected, suggesting that the integration of the two different signals results in a new signal that manifests in late flowering, low protein oxidation during light stress, and enhanced accumulation of anthocyanins. Anthocyanins 285-297 ascorbate peroxidase 1 Arabidopsis thaliana 52-63 17905899-9 2007 SIZ1-dependent, drought-responsive genes include those encoding enzymes of the anthocyanin synthesis pathway and jasmonate response. Anthocyanins 79-90 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 0-4 17760970-4 2007 RESULTS: Total anthocyanin content at full maturity correlated well with the cumulative expression of F3H, UFGT and GST throughout ripening. Anthocyanins 15-26 glutathione S-transferase kappa 1 Homo sapiens 116-119 17512652-6 2007 These results suggest that anthocyanins may attenuate the development of asthma by downregulating Th2 cytokines, proinflammatory cytokines, and COX-2. Anthocyanins 27-39 heart and neural crest derivatives expressed 2 Mus musculus 98-101 17512652-6 2007 These results suggest that anthocyanins may attenuate the development of asthma by downregulating Th2 cytokines, proinflammatory cytokines, and COX-2. Anthocyanins 27-39 cytochrome c oxidase II, mitochondrial Mus musculus 144-149 17634269-0 2007 Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. Anthocyanins 0-12 nuclear factor kappa B subunit 1 Homo sapiens 21-42 17634269-3 2007 In cultured monocytes, anthocyanins isolated from bilberries and black currants (Medox) efficiently suppressed LPS-induced activation of NF-kappaB. Anthocyanins 23-35 nuclear factor kappa B subunit 1 Homo sapiens 137-146 17634269-8 2007 These data suggest that anthocyanin supplementation may have a role in the prevention or treatment of chronic inflammatory diseases by inhibition of NF-kappaB transactivation and deceased plasma concentrations of pro-inflammatory chemokines, cytokines, and inflammatory mediators. Anthocyanins 24-35 nuclear factor kappa B subunit 1 Homo sapiens 149-158 17693536-3 2007 Light-grown hsr8 plants exhibited increased starch and anthocyanin and reduced chlorophyll content in response to glucose treatment. Anthocyanins 55-66 NAD(P)-binding Rossmann-fold superfamily protein Arabidopsis thaliana 12-16 17766401-5 2007 Transgenic plants expressing a chimeric repressor version of the TTG2 protein (TTG2:SRDX) showed defects in trichome formation, anthocyanin accumulation, seed color pigmentation, and differentiation of root hairless cells. Anthocyanins 128-139 WRKY family transcription factor family protein Arabidopsis thaliana 65-69 17766401-5 2007 Transgenic plants expressing a chimeric repressor version of the TTG2 protein (TTG2:SRDX) showed defects in trichome formation, anthocyanin accumulation, seed color pigmentation, and differentiation of root hairless cells. Anthocyanins 128-139 WRKY family transcription factor family protein Arabidopsis thaliana 79-83 18044341-0 2007 [Effect of anthocyanins from Aronia melanocarpa on blood pressure, concentration of endothelin-1 and lipids in patients with metabolic syndrome]. Anthocyanins 11-23 endothelin 1 Homo sapiens 84-96 18044341-6 2007 It seems to result from anthocyanins influence on blood pressure, serum lipid and endothelin-1 level. Anthocyanins 24-36 endothelin 1 Homo sapiens 82-94 17526919-6 2007 These results suggest that MdMYBA is a key regulatory gene in anthocyanin biosynthesis in apple skin. Anthocyanins 62-73 transcription factor MYB113-like Malus domestica 27-33 17376028-5 2007 In bhlh32 mutant plants in P(i)-sufficient conditions, expression of several P(i) starvation-induced genes, formation of anthocyanins, total P(i) content and root hair formation were all significantly increased compared with the wild-type. Anthocyanins 121-133 basic helix-loop-helix 32 Arabidopsis thaliana 3-9 17511019-0 2007 Identification of dimeric anthocyanins and new oligomeric pigments in red wine by means of HPLC-DAD-ESI/MSn. Anthocyanins 26-38 moesin Homo sapiens 104-107 17601828-8 2007 However, catechin-3-O-glucoside inhibited TT12-mediated transport of cyanidin-3-O-glucoside in a dose-dependent manner, while flavan-3-ol aglycones and glycosylated flavonols had no effect on anthocyanin transport. Anthocyanins 192-203 MATE efflux family protein Arabidopsis thaliana 42-46 17434986-1 2007 The tie-dyed1 (tdy1) mutant of maize (Zea mays) produces chlorotic, anthocyanin-accumulating regions in leaves due to the hyperaccumulation of carbohydrates. Anthocyanins 68-79 predicted GPI-anchored protein 58 Zea mays 4-13 17434986-1 2007 The tie-dyed1 (tdy1) mutant of maize (Zea mays) produces chlorotic, anthocyanin-accumulating regions in leaves due to the hyperaccumulation of carbohydrates. Anthocyanins 68-79 predicted GPI-anchored protein 58 Zea mays 15-19 17601828-10 2007 Mutant banyuls (ban) seeds accumulate anthocyanins instead of proanthocyanidins, yet the ban tt12 double mutant exhibits reduced anthocyanin accumulation, which supports the transport data suggesting that TT12 mediates anthocyanin transport in vitro. Anthocyanins 38-49 MATE efflux family protein Arabidopsis thaliana 205-209 17601828-10 2007 Mutant banyuls (ban) seeds accumulate anthocyanins instead of proanthocyanidins, yet the ban tt12 double mutant exhibits reduced anthocyanin accumulation, which supports the transport data suggesting that TT12 mediates anthocyanin transport in vitro. Anthocyanins 129-140 MATE efflux family protein Arabidopsis thaliana 93-97 17053893-7 2007 At least three different bHLH domain transcription factors promote anthocyanin synthesis, and transcripts for one of these, i.e. GL3 were found to be sixfold enhanced by nitrogen deficiency in rosette leaves. Anthocyanins 67-78 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 129-132 17601828-10 2007 Mutant banyuls (ban) seeds accumulate anthocyanins instead of proanthocyanidins, yet the ban tt12 double mutant exhibits reduced anthocyanin accumulation, which supports the transport data suggesting that TT12 mediates anthocyanin transport in vitro. Anthocyanins 129-140 MATE efflux family protein Arabidopsis thaliana 205-209 17711725-6 2007 ABCA1 expressions at mRNA and protein levels were also significantly enhanced after anthocyanins treatment in these cells and these effects could be blocked by co-treatment with DIDS, an inhibitor of the transport activities of ABCA1 and blocker of apoAI-mediated cholesterol efflux. Anthocyanins 84-96 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 0-5 17711725-6 2007 ABCA1 expressions at mRNA and protein levels were also significantly enhanced after anthocyanins treatment in these cells and these effects could be blocked by co-treatment with DIDS, an inhibitor of the transport activities of ABCA1 and blocker of apoAI-mediated cholesterol efflux. Anthocyanins 84-96 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 228-233 17711725-7 2007 CONCLUSION: These data demonstrate that anthocyanins induce cholesterol efflux from mouse peritoneal macrophage-derived foam cells via regulating ABCA1 expression. Anthocyanins 40-52 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 146-151 17395203-1 2007 The nicotinamide adenine dinucleotide phosphate (NADPH)-dependent enzyme dihydroflavonol 4-reductase (DFR) catalyzes a late step in the biosynthesis of anthocyanins and condensed tannins, two flavonoid classes of importance to plant survival and human nutrition. Anthocyanins 152-164 dihydroflavonol 4-reductase Vitis vinifera 102-105 17409070-7 2007 det1 ddb2 partially enhances the short hypocotyl and suppresses the high anthocyanin content of dark-grown det1 and suppresses the low chlorophyll content, early flowering time (days), and small rosette diameter of light-grown det1. Anthocyanins 73-84 light-mediated development protein 1 / deetiolated1 (DET1) Arabidopsis thaliana 0-4 17409070-7 2007 det1 ddb2 partially enhances the short hypocotyl and suppresses the high anthocyanin content of dark-grown det1 and suppresses the low chlorophyll content, early flowering time (days), and small rosette diameter of light-grown det1. Anthocyanins 73-84 damaged DNA binding 2 Arabidopsis thaliana 5-9 17409070-7 2007 det1 ddb2 partially enhances the short hypocotyl and suppresses the high anthocyanin content of dark-grown det1 and suppresses the low chlorophyll content, early flowering time (days), and small rosette diameter of light-grown det1. Anthocyanins 73-84 light-mediated development protein 1 / deetiolated1 (DET1) Arabidopsis thaliana 107-111 17409070-7 2007 det1 ddb2 partially enhances the short hypocotyl and suppresses the high anthocyanin content of dark-grown det1 and suppresses the low chlorophyll content, early flowering time (days), and small rosette diameter of light-grown det1. Anthocyanins 73-84 light-mediated development protein 1 / deetiolated1 (DET1) Arabidopsis thaliana 107-111 17420179-8 2007 Amount of flavonols and dihydroflavonol in NILs with w1 or w4 were largely similar to the NILs with purple flower suggesting that W1 and W4 affect only anthocyanin biosynthesis. Anthocyanins 152-163 flavonoid 3', 5'-hydroxylase Glycine max 130-139 17381106-2 2007 The regulations of apoptosis and the phase II enzymes glutathione-S-transferase (GST) and quinone reductase (QR) are other potential mechanisms through which flavonoids such as anthocyanins may prevent cancer. Anthocyanins 177-189 glutathione S-transferase kappa 1 Homo sapiens 54-79 17381106-2 2007 The regulations of apoptosis and the phase II enzymes glutathione-S-transferase (GST) and quinone reductase (QR) are other potential mechanisms through which flavonoids such as anthocyanins may prevent cancer. Anthocyanins 177-189 glutathione S-transferase kappa 1 Homo sapiens 81-84 17381106-3 2007 Our study confirmed that anthocyanin fractions from high bush blueberry cultivars increased apoptosis using two different methods: DNA fragmentation and caspase-3 activity. Anthocyanins 25-36 caspase 3 Homo sapiens 153-162 17381106-4 2007 The effect of anthocyanins on the activity of the detoxifying enzymes GST and QR was also determined. Anthocyanins 14-26 glutathione S-transferase kappa 1 Homo sapiens 70-73 17381106-7 2007 There was a significant difference in the caspase-3 activity (P < 0.05) between the control cells and the cells treated with anthocyanins from all of the cultivars. Anthocyanins 128-140 caspase 3 Homo sapiens 42-51 17381106-11 2007 The GST activity was lower (P < 0.05) in cells treated with anthocyanin fractions from all of the cultivars and at all concentrations. Anthocyanins 63-74 glutathione S-transferase kappa 1 Homo sapiens 4-7 17381106-12 2007 These results indicated that apoptosis was confirmed in HT-29 cells when treated with anthocyanins from blueberry cultivars at 50-150 microg/mL concentrations, but these same concentrations decrease QR and GST activities rather than induce them. Anthocyanins 86-98 glutathione S-transferase kappa 1 Homo sapiens 206-209 17053893-10 2007 Together with MYB factors, especially PAP2, GL3 appears to be the BHLH partner for anthocyanin accumulation in response to nitrogen deficiency. Anthocyanins 83-94 Purple acid phosphatases superfamily protein Arabidopsis thaliana 38-42 17053893-10 2007 Together with MYB factors, especially PAP2, GL3 appears to be the BHLH partner for anthocyanin accumulation in response to nitrogen deficiency. Anthocyanins 83-94 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 44-47 17322336-6 2007 Suppression of WRKY75 expression through RNAi silencing resulted in early accumulation of anthocyanin, indicating that the RNAi plants were more susceptible to Pi stress. Anthocyanins 90-101 WRKY DNA-binding protein 75 Arabidopsis thaliana 15-21 17208963-6 2007 VvMYBPA1 did not activate the promoter of VvUFGT, which encodes the anthocyanin-specific enzyme UDP-glucose:flavonoid-3-O-glucosyltransferase, suggesting VvMYBPA1 is specific to regulation of PA biosynthesis in grapes. Anthocyanins 68-79 MYBPA1 protein Vitis vinifera 0-8 17158355-0 2007 Anthocyanin prevents CD40-activated proinflammatory signaling in endothelial cells by regulating cholesterol distribution. Anthocyanins 0-11 CD40 molecule Homo sapiens 21-25 17158355-2 2007 The purpose of this study was to investigate the influence of anthocyanin on CD40-mediated proinflammatory events in human endothelial cells and the underlying possible molecular mechanism. Anthocyanins 62-73 CD40 molecule Homo sapiens 77-81 17158355-3 2007 METHODS AND RESULTS: Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6, IL-8, and monocyte chemoattractant protein-1 through inhibiting CD40-induced nuclear factor-kappaB (NF-kappaB) activation. Anthocyanins 57-68 CD40 molecule Homo sapiens 84-88 17158355-3 2007 METHODS AND RESULTS: Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6, IL-8, and monocyte chemoattractant protein-1 through inhibiting CD40-induced nuclear factor-kappaB (NF-kappaB) activation. Anthocyanins 57-68 interleukin 6 Homo sapiens 147-151 17158355-3 2007 METHODS AND RESULTS: Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6, IL-8, and monocyte chemoattractant protein-1 through inhibiting CD40-induced nuclear factor-kappaB (NF-kappaB) activation. Anthocyanins 57-68 C-X-C motif chemokine ligand 8 Homo sapiens 153-157 17158355-3 2007 METHODS AND RESULTS: Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6, IL-8, and monocyte chemoattractant protein-1 through inhibiting CD40-induced nuclear factor-kappaB (NF-kappaB) activation. Anthocyanins 57-68 C-C motif chemokine ligand 2 Homo sapiens 163-197 17158355-3 2007 METHODS AND RESULTS: Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6, IL-8, and monocyte chemoattractant protein-1 through inhibiting CD40-induced nuclear factor-kappaB (NF-kappaB) activation. Anthocyanins 57-68 CD40 molecule Homo sapiens 217-221 17158355-7 2007 Exposure to anthocyanin not only interrupted TRAF-2 recruitment to lipid rafts but also decreased cholesterol content in Triton X-100 insoluble lipid rafts. Anthocyanins 12-23 TNF receptor associated factor 2 Homo sapiens 45-51 17158355-9 2007 CONCLUSIONS: Our findings suggest that anthocyanin protects from CD40-induced proinflammatory signaling by preventing TRAF-2 translocation to lipid rafts through regulation of cholesterol distribution, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin. Anthocyanins 39-50 CD40 molecule Homo sapiens 65-69 17158355-9 2007 CONCLUSIONS: Our findings suggest that anthocyanin protects from CD40-induced proinflammatory signaling by preventing TRAF-2 translocation to lipid rafts through regulation of cholesterol distribution, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin. Anthocyanins 39-50 TNF receptor associated factor 2 Homo sapiens 118-124 17158355-9 2007 CONCLUSIONS: Our findings suggest that anthocyanin protects from CD40-induced proinflammatory signaling by preventing TRAF-2 translocation to lipid rafts through regulation of cholesterol distribution, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin. Anthocyanins 295-306 CD40 molecule Homo sapiens 65-69 17158355-9 2007 CONCLUSIONS: Our findings suggest that anthocyanin protects from CD40-induced proinflammatory signaling by preventing TRAF-2 translocation to lipid rafts through regulation of cholesterol distribution, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin. Anthocyanins 295-306 TNF receptor associated factor 2 Homo sapiens 118-124 17316172-2 2007 A regulatory gene, VvMYBA1, which could activate anthocyanin biosynthesis in a transient assay, was recently shown not to be transcribed in white berries due to the presence of a retrotransposon in the promoter. Anthocyanins 49-60 MYBA1 Vitis vinifera 19-26 17319847-0 2007 PIF3 regulates anthocyanin biosynthesis in an HY5-dependent manner with both factors directly binding anthocyanin biosynthetic gene promoters in Arabidopsis. Anthocyanins 15-26 phytochrome interacting factor 3 Arabidopsis thaliana 0-4 17319847-0 2007 PIF3 regulates anthocyanin biosynthesis in an HY5-dependent manner with both factors directly binding anthocyanin biosynthetic gene promoters in Arabidopsis. Anthocyanins 15-26 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 46-49 17319847-0 2007 PIF3 regulates anthocyanin biosynthesis in an HY5-dependent manner with both factors directly binding anthocyanin biosynthetic gene promoters in Arabidopsis. Anthocyanins 102-113 phytochrome interacting factor 3 Arabidopsis thaliana 0-4 17319847-0 2007 PIF3 regulates anthocyanin biosynthesis in an HY5-dependent manner with both factors directly binding anthocyanin biosynthetic gene promoters in Arabidopsis. Anthocyanins 102-113 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 46-49 17319847-3 2007 Here we investigated the functional relationship between two such transcription factors, PIF3 and HY5, and their effects on anthocyanin biosynthesis. Anthocyanins 124-135 phytochrome interacting factor 3 Arabidopsis thaliana 89-93 17319847-3 2007 Here we investigated the functional relationship between two such transcription factors, PIF3 and HY5, and their effects on anthocyanin biosynthesis. Anthocyanins 124-135 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 98-101 17319847-5 2007 We found that both PIF3 and HY5 positively regulate anthocyanin biosynthesis by activating the transcription of the same anthocyanin biosynthetic genes, but the positive effects of PIF3 required functional HY5. Anthocyanins 52-63 phytochrome interacting factor 3 Arabidopsis thaliana 19-23 17319847-5 2007 We found that both PIF3 and HY5 positively regulate anthocyanin biosynthesis by activating the transcription of the same anthocyanin biosynthetic genes, but the positive effects of PIF3 required functional HY5. Anthocyanins 52-63 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 28-31 17319847-5 2007 We found that both PIF3 and HY5 positively regulate anthocyanin biosynthesis by activating the transcription of the same anthocyanin biosynthetic genes, but the positive effects of PIF3 required functional HY5. Anthocyanins 121-132 phytochrome interacting factor 3 Arabidopsis thaliana 19-23 17319847-5 2007 We found that both PIF3 and HY5 positively regulate anthocyanin biosynthesis by activating the transcription of the same anthocyanin biosynthetic genes, but the positive effects of PIF3 required functional HY5. Anthocyanins 121-132 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 28-31 17319847-6 2007 Chromatin immunoprecipitation analyses indicated that both PIF3 and HY5 regulate anthocyanin biosynthetic gene expression by directly binding to different regions of the gene promoters in vivo. Anthocyanins 81-92 phytochrome interacting factor 3 Arabidopsis thaliana 59-63 17319847-6 2007 Chromatin immunoprecipitation analyses indicated that both PIF3 and HY5 regulate anthocyanin biosynthetic gene expression by directly binding to different regions of the gene promoters in vivo. Anthocyanins 81-92 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 68-71 17319847-8 2007 Collectively, these data show that PIF3 and HY5 regulate anthocyanin biosynthesis by simultaneously binding anthocyanin biosynthetic gene promoters at separate sequence elements. Anthocyanins 57-68 phytochrome interacting factor 3 Arabidopsis thaliana 35-39 17319847-8 2007 Collectively, these data show that PIF3 and HY5 regulate anthocyanin biosynthesis by simultaneously binding anthocyanin biosynthetic gene promoters at separate sequence elements. Anthocyanins 57-68 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 44-47 17319847-8 2007 Collectively, these data show that PIF3 and HY5 regulate anthocyanin biosynthesis by simultaneously binding anthocyanin biosynthetic gene promoters at separate sequence elements. Anthocyanins 108-119 phytochrome interacting factor 3 Arabidopsis thaliana 35-39 17319847-8 2007 Collectively, these data show that PIF3 and HY5 regulate anthocyanin biosynthesis by simultaneously binding anthocyanin biosynthetic gene promoters at separate sequence elements. Anthocyanins 108-119 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 44-47 17083738-9 2006 Most interestingly was the opposite temporal fluctuation in transcript abundance between early responsive genes in defense (CHS and IFS1) and F3H, the gene encoding a pivotal enzyme in the synthesis of anthocyanins, proanthocyanidins and flavonols. Anthocyanins 202-214 isoflavone synthase 1 Glycine max 132-136 17217468-5 2007 By contrast, cytokinin-dependent stimulation of anthocyanin accumulation occurs only in light, and interacts with the signalling pathway downstream of cryptochrome 1 (CRY1) at the level of transcript accumulation of anthocyanin biosynthetic genes. Anthocyanins 48-59 cryptochrome 1 Arabidopsis thaliana 151-165 17217468-5 2007 By contrast, cytokinin-dependent stimulation of anthocyanin accumulation occurs only in light, and interacts with the signalling pathway downstream of cryptochrome 1 (CRY1) at the level of transcript accumulation of anthocyanin biosynthetic genes. Anthocyanins 48-59 cryptochrome 1 Arabidopsis thaliana 167-171 17217468-5 2007 By contrast, cytokinin-dependent stimulation of anthocyanin accumulation occurs only in light, and interacts with the signalling pathway downstream of cryptochrome 1 (CRY1) at the level of transcript accumulation of anthocyanin biosynthetic genes. Anthocyanins 216-227 cryptochrome 1 Arabidopsis thaliana 151-165 17217468-5 2007 By contrast, cytokinin-dependent stimulation of anthocyanin accumulation occurs only in light, and interacts with the signalling pathway downstream of cryptochrome 1 (CRY1) at the level of transcript accumulation of anthocyanin biosynthetic genes. Anthocyanins 216-227 cryptochrome 1 Arabidopsis thaliana 167-171 17217468-6 2007 Mutants in elongated hypocotyl 5 (hy5), a downstream intermediate in the CRY1 signalling pathway, show a reduced induction of anthocyanin accumulation in blue light by cytokinins, similar to that observed for cryptochrome (cry1) mutants. Anthocyanins 126-137 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 34-37 17217468-6 2007 Mutants in elongated hypocotyl 5 (hy5), a downstream intermediate in the CRY1 signalling pathway, show a reduced induction of anthocyanin accumulation in blue light by cytokinins, similar to that observed for cryptochrome (cry1) mutants. Anthocyanins 126-137 cryptochrome 1 Arabidopsis thaliana 73-77 17217468-8 2007 As both cryptochrome and cytokinin signalling pathways increase HY5 protein levels, and as HY5 binds to the promoters of anthocyanin biosynthetic enzymes to stimulate gene expression, it is concluded that the regulation of HY5 protein stability represents a point of convergence between cryptochrome and cytokinin signalling pathways. Anthocyanins 121-132 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 91-94 17217468-8 2007 As both cryptochrome and cytokinin signalling pathways increase HY5 protein levels, and as HY5 binds to the promoters of anthocyanin biosynthetic enzymes to stimulate gene expression, it is concluded that the regulation of HY5 protein stability represents a point of convergence between cryptochrome and cytokinin signalling pathways. Anthocyanins 121-132 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 91-94 17251177-8 2007 The PHYB1OE lines showed mild effects on the inhibition of stem elongation and anthocyanin accumulation and little or no effect on the red light high irradiance response. Anthocyanins 79-90 phytochrome B1 Solanum lycopersicum 4-9 17251177-9 2007 By contrast, the PHYB2OE lines showed a strong inhibition of elongation, enhancement of anthocyanin accumulation, and a strong amplification of the red light high irradiance response. Anthocyanins 88-99 phytochrome B2 Solanum lycopersicum 17-22 17221259-3 2007 This report examines the effect of human selection on variable skin color by examining the variation present in the gene VvmybA1, a transcriptional regulator of anthocyanin biosynthesis. Anthocyanins 161-172 transcription factor MYB90 Vitis vinifera 121-128 17404384-6 2007 Further analysis demonstrated that UGE enzymatic activity was positively correlated with anthocyanin accumulation in apple skin. Anthocyanins 89-100 bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 1 Malus domestica 35-38 17083738-9 2006 Most interestingly was the opposite temporal fluctuation in transcript abundance between early responsive genes in defense (CHS and IFS1) and F3H, the gene encoding a pivotal enzyme in the synthesis of anthocyanins, proanthocyanidins and flavonols. Anthocyanins 202-214 flavanone 3-hydroxylase Glycine max 142-145 16924546-4 2006 Berry colour results from the synthesis and accumulation of anthocyanins in the berry skin, which in plants is commonly regulated by transcription factors belonging to the MYB and bHLH families. Anthocyanins 60-72 MYB proto-oncogene, transcription factor Homo sapiens 172-175 16857844-10 2006 These results suggest that chronic diet intake of anthocyanin-rich extract from black rice may enhance plaque stabilization in old apoE-deficient mice. Anthocyanins 50-61 apolipoprotein E Mus musculus 131-135 17002429-8 2006 Transgenic lines of P. hybrida expressing the pap1 gene showed unusual patterns of UV-A-inducible pigmentation and anthocyanin accumulation in parenchymatic and medulla cells. Anthocyanins 115-126 phosphatidic acid phosphatase 1 Arabidopsis thaliana 46-50 16921400-10 2006 CONCLUSIONS AND IMPLICATIONS: Anthocyanins presenting a hydroxyl residue at position 3" are able to inhibit PDGF(AB)-induced VEGF expression by preventing activation of p38 MAPK and JNK in VSMCs. Anthocyanins 30-42 vascular endothelial growth factor A Homo sapiens 125-129 16921400-10 2006 CONCLUSIONS AND IMPLICATIONS: Anthocyanins presenting a hydroxyl residue at position 3" are able to inhibit PDGF(AB)-induced VEGF expression by preventing activation of p38 MAPK and JNK in VSMCs. Anthocyanins 30-42 mitogen-activated protein kinase 1 Homo sapiens 169-172 16921400-10 2006 CONCLUSIONS AND IMPLICATIONS: Anthocyanins presenting a hydroxyl residue at position 3" are able to inhibit PDGF(AB)-induced VEGF expression by preventing activation of p38 MAPK and JNK in VSMCs. Anthocyanins 30-42 mitogen-activated protein kinase 3 Homo sapiens 173-177 16921400-10 2006 CONCLUSIONS AND IMPLICATIONS: Anthocyanins presenting a hydroxyl residue at position 3" are able to inhibit PDGF(AB)-induced VEGF expression by preventing activation of p38 MAPK and JNK in VSMCs. Anthocyanins 30-42 mitogen-activated protein kinase 8 Homo sapiens 182-185 17012603-3 2006 However, vte2, and to a lesser extent vte1, exhibited dramatic phenotypes under low temperature (i.e., increased anthocyanin levels and reduced growth and seed production). Anthocyanins 113-124 homogentisate phytyltransferase 1 Arabidopsis thaliana 9-13 16829586-10 2006 Based on pigment analysis, measurements of PSII activity, and assays of the oxidation status of proteins we propose that the discrepancy between amounts of Elip transcripts and proteins in light stress-preadapted or senescent leaves is related to a presence of photoprotective anthocyanins or to lower chlorophyll availability, respectively. Anthocyanins 277-289 Chlorophyll A-B binding family protein Arabidopsis thaliana 156-160 17062434-5 2006 RESULTS: Anthocyanins at 40 mg/kg significantly decreased the levels of TNFalpha in serum and PGE2 in paws, simultaneously improving the anti-oxidative status of AIA. Anthocyanins 9-21 tumor necrosis factor Rattus norvegicus 72-80 16787048-9 2006 Our results show that in the mouse small intestine, ACN absorption is not solely dependent on the activity of the SGLT1 transporter, as d-glucose and phloridzin had only a slight effect on uptake. Anthocyanins 52-55 solute carrier family 5 (sodium/glucose cotransporter), member 1 Mus musculus 114-119 16770836-0 2006 Simultaneous separation and identification of oligomeric procyanidins and anthocyanin-derived pigments in raw red wine by HPLC-UV-ESI-MSn. Anthocyanins 74-85 moesin Homo sapiens 134-137 16442129-6 2006 In the immunohistochemical observation, anthocyanins remarkably reduced a number of phospho-c-Jun N-terminal kinase (p-JNK) and p53 immunopositive cells in the infarct area. Anthocyanins 40-52 mitogen-activated protein kinase 8 Rattus norvegicus 119-122 16648217-5 2006 After 5 d of HL, both wild-type and vtc2-2 plants accumulated anthocyanins, increased their total ascorbate content, and lost 10% of photosystem II efficiency, but showed no bleaching. Anthocyanins 62-74 GDP-L-galactose phosphorylase 1 Arabidopsis thaliana 36-40 16648217-6 2006 Anthocyanin and total ascorbate concentrations in vtc2-2 were respectively 34% and 20% of wild type, potentially leading to enhanced oxidative stress in vtc2-2. Anthocyanins 0-11 GDP-L-galactose phosphorylase 1 Arabidopsis thaliana 50-54 16648217-6 2006 Anthocyanin and total ascorbate concentrations in vtc2-2 were respectively 34% and 20% of wild type, potentially leading to enhanced oxidative stress in vtc2-2. Anthocyanins 0-11 GDP-L-galactose phosphorylase 1 Arabidopsis thaliana 153-157 16709193-2 2006 First, the GUS activity generated in planta from a TT8::uidA construct revealed cell-specific activation of the TT8 promoter consistent with the known involvement of the TT8 bHLH factor in proanthocyanidin, anthocyanin and mucilage biosynthesis. Anthocyanins 207-218 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 112-115 16709193-2 2006 First, the GUS activity generated in planta from a TT8::uidA construct revealed cell-specific activation of the TT8 promoter consistent with the known involvement of the TT8 bHLH factor in proanthocyanidin, anthocyanin and mucilage biosynthesis. Anthocyanins 207-218 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 112-115 16308314-0 2006 Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation. Anthocyanins 23-36 kinase insert domain receptor Homo sapiens 47-92 16442129-6 2006 In the immunohistochemical observation, anthocyanins remarkably reduced a number of phospho-c-Jun N-terminal kinase (p-JNK) and p53 immunopositive cells in the infarct area. Anthocyanins 40-52 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 128-131 16442129-7 2006 Moreover, Western blotting analysis indicated that anthocyanins suppressed the activation of JNK and up-regulation of p53. Anthocyanins 51-63 mitogen-activated protein kinase 8 Rattus norvegicus 93-96 16442129-7 2006 Moreover, Western blotting analysis indicated that anthocyanins suppressed the activation of JNK and up-regulation of p53. Anthocyanins 51-63 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 118-121 16442129-8 2006 Thus, our data suggested that anthocyanins reduced neuronal damage induced by focal cerebral ischemia through blocking the JNK and p53 signaling pathway. Anthocyanins 30-42 mitogen-activated protein kinase 8 Rattus norvegicus 123-126 16442129-8 2006 Thus, our data suggested that anthocyanins reduced neuronal damage induced by focal cerebral ischemia through blocking the JNK and p53 signaling pathway. Anthocyanins 30-42 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 131-134 16531484-0 2006 Cryptochrome 1 from Brassica napus is up-regulated by blue light and controls hypocotyl/stem growth and anthocyanin accumulation. Anthocyanins 104-115 cryptochrome-1 Brassica napus 0-14 16531484-8 2006 The antisense-BnCRY1 Brassica transgenic seedlings accumulated negligible levels of CRY1 protein and displayed an elongated hypocotyl when grown under continuous white or blue light (but not under red or far-red light); the accumulation of anthocyanins was also reduced significantly. Anthocyanins 240-252 cryptochrome-1-like Brassica napus 14-20 16531484-8 2006 The antisense-BnCRY1 Brassica transgenic seedlings accumulated negligible levels of CRY1 protein and displayed an elongated hypocotyl when grown under continuous white or blue light (but not under red or far-red light); the accumulation of anthocyanins was also reduced significantly. Anthocyanins 240-252 cryptochrome-1-like Brassica napus 16-20 16483547-4 2006 In this study, we have shown the gene expression profile in human adipocytes treated with anthocyanins (cyanidin 3-glucoside; C3G or cyanidin; Cy). Anthocyanins 90-102 Rap guanine nucleotide exchange factor 1 Homo sapiens 126-129 16534575-0 2006 Characterization and quantification of anthocyanins in selected artichoke (Cynara scolymus L.) cultivars by HPLC-DAD-ESI-MSn. Anthocyanins 39-51 moesin Homo sapiens 121-124 16457818-0 2006 Anthocyanins from soybean seed coat inhibit the expression of TNF-alpha-induced genes associated with ischemia/reperfusion in endothelial cell by NF-kappaB-dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivo. Anthocyanins 0-12 tumor necrosis factor Rattus norvegicus 62-71 16524606-1 2006 Dihydroflavonol 4-reductase (DFR, EC 1.1.1.219) catalyzes the reduction of dihydroflavonols to leucoanthocyanins, a key "late" step in the biosynthesis of anthocyanins. Anthocyanins 100-112 putative anthocyanidin reductase Citrus sinensis 0-27 16524606-1 2006 Dihydroflavonol 4-reductase (DFR, EC 1.1.1.219) catalyzes the reduction of dihydroflavonols to leucoanthocyanins, a key "late" step in the biosynthesis of anthocyanins. Anthocyanins 100-112 putative anthocyanidin reductase Citrus sinensis 29-32 16524606-2 2006 In this study we showed that a strong reduction in DFR expression occurs in the non-red orange cultivar (Navel and Ovale) compared to that of the red orange (Tarocco) suggesting that the enzyme could be involved in the lack of production of anthocyanins. Anthocyanins 241-253 putative anthocyanidin reductase Citrus sinensis 51-54 16524606-8 2006 In addition, here we reported the successful expression of orange DFR cDNAs leading to an active DFR enzyme which converts dihydroquercetin to leucoanthocyanidin, thus confirming the involvement of the isolated genes in the biosynthesis of anthocyanins. Anthocyanins 143-161 putative anthocyanidin reductase Citrus sinensis 66-69 16524606-8 2006 In addition, here we reported the successful expression of orange DFR cDNAs leading to an active DFR enzyme which converts dihydroquercetin to leucoanthocyanidin, thus confirming the involvement of the isolated genes in the biosynthesis of anthocyanins. Anthocyanins 143-161 putative anthocyanidin reductase Citrus sinensis 97-100 16524606-8 2006 In addition, here we reported the successful expression of orange DFR cDNAs leading to an active DFR enzyme which converts dihydroquercetin to leucoanthocyanidin, thus confirming the involvement of the isolated genes in the biosynthesis of anthocyanins. Anthocyanins 240-252 putative anthocyanidin reductase Citrus sinensis 66-69 16524606-8 2006 In addition, here we reported the successful expression of orange DFR cDNAs leading to an active DFR enzyme which converts dihydroquercetin to leucoanthocyanidin, thus confirming the involvement of the isolated genes in the biosynthesis of anthocyanins. Anthocyanins 240-252 putative anthocyanidin reductase Citrus sinensis 97-100 16649106-2 2006 In contrast, trichomes were strongly induced in seedling stems and moderately induced in leaves of a hairy, purple phenotype transformed with a 2.2 kb allele of the maize anthocyanin regulator LEAF COLOUR (Lc), but only weakly induced by BOOSTER (B-Peru), the maize Lc 2.4 kb allele, or the Arabidopsis trichome MYB gene GLABRA1 (GL1). Anthocyanins 171-182 anthocyanin regulatory R-S protein-like Zea mays 238-245 16649106-2 2006 In contrast, trichomes were strongly induced in seedling stems and moderately induced in leaves of a hairy, purple phenotype transformed with a 2.2 kb allele of the maize anthocyanin regulator LEAF COLOUR (Lc), but only weakly induced by BOOSTER (B-Peru), the maize Lc 2.4 kb allele, or the Arabidopsis trichome MYB gene GLABRA1 (GL1). Anthocyanins 171-182 myb domain protein 0 Arabidopsis thaliana 321-328 16649106-2 2006 In contrast, trichomes were strongly induced in seedling stems and moderately induced in leaves of a hairy, purple phenotype transformed with a 2.2 kb allele of the maize anthocyanin regulator LEAF COLOUR (Lc), but only weakly induced by BOOSTER (B-Peru), the maize Lc 2.4 kb allele, or the Arabidopsis trichome MYB gene GLABRA1 (GL1). Anthocyanins 171-182 myb domain protein 0 Arabidopsis thaliana 330-333 16457818-1 2006 We examined the inhibition of the expression of some inflammatory genes associated with ischemia-reperfusion (I/R) injury by anthocyanins isolated from black soybean seed coat in tumor necrosis factor-alpha (TNF-alpha)-treated bovine aortic endothelial cells. Anthocyanins 125-137 tumor necrosis factor Rattus norvegicus 208-217 16457818-3 2006 Western blot analysis and luciferase activity assay showed that anthocyanins inhibited TNF-alpha-induced vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and cyclooxygenase-2 levels, which is through NF-kappaB-dependent pathway. Anthocyanins 64-76 tumor necrosis factor Rattus norvegicus 87-96 16457818-3 2006 Western blot analysis and luciferase activity assay showed that anthocyanins inhibited TNF-alpha-induced vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and cyclooxygenase-2 levels, which is through NF-kappaB-dependent pathway. Anthocyanins 64-76 vascular cell adhesion molecule 1 Rattus norvegicus 105-173 16457818-3 2006 Western blot analysis and luciferase activity assay showed that anthocyanins inhibited TNF-alpha-induced vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and cyclooxygenase-2 levels, which is through NF-kappaB-dependent pathway. Anthocyanins 64-76 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 179-195 16288501-0 2006 Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. Anthocyanins 0-14 endothelin 1 Homo sapiens 24-36 17100629-4 2006 Treatment with flavonoids such as luteolin, apigenin, quercetin, genistein, (-)-epigallocatechin gallate, and anthocyanidin resulted in significant downregulation of LPS-elicited TNF-alpha and nitric oxide (NO) production and diminished lethal shock. Anthocyanins 110-123 tumor necrosis factor Mus musculus 179-188 16288501-7 2006 In particular, we examined the effect of anthocyanidins on endothelial heme oxygenase-1 (HO-1), an inducible stress protein. Anthocyanins 41-55 heme oxygenase 1 Homo sapiens 71-87 16339850-10 2006 However, the col3 mutation exerts opposing effects on cop1 and det1 in terms of lateral roots and anthocyanin accumulation, suggesting that COL3 also has activities that are independent of COP1 and DET1. Anthocyanins 98-109 CONSTANS-like 3 Arabidopsis thaliana 13-17 16339850-10 2006 However, the col3 mutation exerts opposing effects on cop1 and det1 in terms of lateral roots and anthocyanin accumulation, suggesting that COL3 also has activities that are independent of COP1 and DET1. Anthocyanins 98-109 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 54-58 16339850-10 2006 However, the col3 mutation exerts opposing effects on cop1 and det1 in terms of lateral roots and anthocyanin accumulation, suggesting that COL3 also has activities that are independent of COP1 and DET1. Anthocyanins 98-109 light-mediated development protein 1 / deetiolated1 (DET1) Arabidopsis thaliana 63-67 16399804-7 2006 Phylogenetic analysis, supported by comparative mapping in rice and maize (Zea mays), showed that Rc, a positive regulator of proanthocyanidin, is orthologous with INTENSIFIER1, a negative regulator of anthocyanin production in maize, and is not in the same clade as rice bHLH anthocyanin regulators. Anthocyanins 202-213 transcription factor BHLH42 Zea mays 164-176 16399804-7 2006 Phylogenetic analysis, supported by comparative mapping in rice and maize (Zea mays), showed that Rc, a positive regulator of proanthocyanidin, is orthologous with INTENSIFIER1, a negative regulator of anthocyanin production in maize, and is not in the same clade as rice bHLH anthocyanin regulators. Anthocyanins 277-288 transcription factor BHLH42 Zea mays 164-176 16299170-7 2005 However, the observed phenotypes were correlated with the amount of total shoot anthocyanin at low temperature and with the transcription of the flavonoid pathway genes PAL1 and CHS. Anthocyanins 80-91 PHE ammonia lyase 1 Arabidopsis thaliana 169-173 16299184-0 2005 Sucrose-specific induction of anthocyanin biosynthesis in Arabidopsis requires the MYB75/PAP1 gene. Anthocyanins 30-41 production of anthocyanin pigment 1 Arabidopsis thaliana 83-88 16299184-0 2005 Sucrose-specific induction of anthocyanin biosynthesis in Arabidopsis requires the MYB75/PAP1 gene. Anthocyanins 30-41 phosphatidic acid phosphatase 1 Arabidopsis thaliana 89-93 16107338-0 2005 Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages: the role of the peroxisome proliferator-activated receptor {gamma}-liver X receptor {alpha}-ABCA1 pathway. Anthocyanins 0-12 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 166-171 16107338-6 2005 Addition of geranylgeranyl pyrophosphate ammonium salt or GW9662 markedly inhibited the anthocyanin-induced increase of ABCA1 gene expression and apoAI-mediated cholesterol efflux. Anthocyanins 88-99 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 120-125 16107338-7 2005 These data demonstrated that anthocyanin induces cholesterol efflux from mouse peritoneal macrophages and macrophage-derived foam cells and that stimulation of cholesterol efflux by anthocyanin is mediated, at least in part, by peroxisome proliferator-activated receptor gamma-liver X receptor alpha-ABCA1 signaling pathway activation. Anthocyanins 182-193 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 300-305 16498804-4 2005 CONCLUSION: 30 days long administration of 240 mg of anthocyanins a day, caused a substantial increase of glutathione peroxidase and catalase activities. Anthocyanins 53-65 catalase Homo sapiens 133-141 16051450-0 2005 Two novel transposable elements in a cytochrome P450 gene govern anthocyanin biosynthesis of commercial petunias. Anthocyanins 65-76 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-52 16167896-2 2005 When coupled with constitutive expression of PAP1, a positive regulator of anthocyanin biosynthesis, TT2 expression in Arabidopsis led to accumulation of proanthocyanidins, but only in a subset of cells in which the BANYULS promoter is naturally expressed. Anthocyanins 75-86 phosphatidic acid phosphatase 1 Arabidopsis thaliana 45-49 16167896-2 2005 When coupled with constitutive expression of PAP1, a positive regulator of anthocyanin biosynthesis, TT2 expression in Arabidopsis led to accumulation of proanthocyanidins, but only in a subset of cells in which the BANYULS promoter is naturally expressed. Anthocyanins 75-86 Duplicated homeodomain-like superfamily protein Arabidopsis thaliana 101-104 15963474-9 2005 These findings provide the first molecular basis that anthocyanidins with ortho-dihydroxyphenyl structure may have anti-inflammatory properties through the inhibition of MAPK-mediated COX-2 expression. Anthocyanins 54-68 mitogen-activated protein kinase 1 Mus musculus 170-174 16113228-2 2005 tan mutant embryos share many characteristics with the leafy cotyledon (lec) class of mutants in that they accumulate anthocyanin, are intolerant of desiccation, form trichomes on cotyledons, and have reduced accumulation of storage proteins and lipids. Anthocyanins 118-129 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 0-3 16834098-3 2005 It is also demonstrated, for a large series of anthocyanin-copigment pairs, that the standard Gibbs free energy of complex formation decreases linearly with EA(Anthoc) - IP(Cop), the difference between the electron affinity of the anthocyanin, EA(Anthoc), and the ionization potential of the copigment, IP(Cop). Anthocyanins 47-58 caspase recruitment domain family member 16 Homo sapiens 173-176 16834098-3 2005 It is also demonstrated, for a large series of anthocyanin-copigment pairs, that the standard Gibbs free energy of complex formation decreases linearly with EA(Anthoc) - IP(Cop), the difference between the electron affinity of the anthocyanin, EA(Anthoc), and the ionization potential of the copigment, IP(Cop). Anthocyanins 47-58 caspase recruitment domain family member 16 Homo sapiens 306-309 16834098-3 2005 It is also demonstrated, for a large series of anthocyanin-copigment pairs, that the standard Gibbs free energy of complex formation decreases linearly with EA(Anthoc) - IP(Cop), the difference between the electron affinity of the anthocyanin, EA(Anthoc), and the ionization potential of the copigment, IP(Cop). Anthocyanins 231-242 caspase recruitment domain family member 16 Homo sapiens 173-176 15963474-0 2005 Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. Anthocyanins 0-14 prostaglandin-endoperoxide synthase 2 Mus musculus 23-39 15963474-1 2005 The effects of anthocyanidins, the aglycon nucleuses of anthocyanins widely occurring in reddish fruits and vegetables, on the expression of cyclooxygenase-2 (COX-2) were investigated in lipopolysaccharide (LPS)-activated murine macrophage RAW264 cells. Anthocyanins 15-29 prostaglandin-endoperoxide synthase 2 Mus musculus 141-157 15963474-1 2005 The effects of anthocyanidins, the aglycon nucleuses of anthocyanins widely occurring in reddish fruits and vegetables, on the expression of cyclooxygenase-2 (COX-2) were investigated in lipopolysaccharide (LPS)-activated murine macrophage RAW264 cells. Anthocyanins 15-29 prostaglandin-endoperoxide synthase 2 Mus musculus 159-164 15963474-1 2005 The effects of anthocyanidins, the aglycon nucleuses of anthocyanins widely occurring in reddish fruits and vegetables, on the expression of cyclooxygenase-2 (COX-2) were investigated in lipopolysaccharide (LPS)-activated murine macrophage RAW264 cells. Anthocyanins 56-68 prostaglandin-endoperoxide synthase 2 Mus musculus 141-157 15963474-1 2005 The effects of anthocyanidins, the aglycon nucleuses of anthocyanins widely occurring in reddish fruits and vegetables, on the expression of cyclooxygenase-2 (COX-2) were investigated in lipopolysaccharide (LPS)-activated murine macrophage RAW264 cells. Anthocyanins 56-68 prostaglandin-endoperoxide synthase 2 Mus musculus 159-164 15963474-2 2005 Of five anthocyanidins, delphinidin and cyanidin inhibited LPS-induced COX-2 expression, but pelargonidin, peonidin and malvidin did not. Anthocyanins 8-22 prostaglandin-endoperoxide synthase 2 Mus musculus 71-76 16115355-3 2005 In the present study, the protective effect of cyanidin-3-O-beta-glucopyranoside (C-3-G; an anthocyanin contained in oranges, blackberries, strawberries and cranberries) against AFB1- and OTA-induced cytotoxicity was investigated in a human hepatoma-derived cell line (Hep G2) and a human colonic adenocarcinoma cell line (CaCo-2). Anthocyanins 92-103 Rap guanine nucleotide exchange factor 1 Homo sapiens 82-87 15963474-9 2005 These findings provide the first molecular basis that anthocyanidins with ortho-dihydroxyphenyl structure may have anti-inflammatory properties through the inhibition of MAPK-mediated COX-2 expression. Anthocyanins 54-68 prostaglandin-endoperoxide synthase 2 Mus musculus 184-189 16138681-0 2005 Utilization of capillary electrophoresis/mass spectrometry (CE/MSn) for the study of anthocyanin dyes. Anthocyanins 85-96 moesin Homo sapiens 63-66 15978035-4 2005 The aim of this work was to determine whether a homologue of rat liver bilitranslocase is expressed in carnation petals, where it might play a role in the membrane transport of anthocyanins. Anthocyanins 177-189 ceruloplasmin Rattus norvegicus 71-86 15923324-10 2005 The sac9 mutants have characteristics of a constitutive stress response, including dwarfism, closed stomata, and anthocyanin accumulation, and they overexpress stress-induced genes and overaccumulate reactive-oxygen species. Anthocyanins 113-124 sacI homology domain-containing protein / WW domain-containing protein Arabidopsis thaliana 4-8 15908594-3 2005 We showed that loss-of-function atmdr1 and atpgp1 mutants display hypersensitivity to far-red, red, and blue-light inhibition of hypocotyl elongation, reduced chlorophyll and anthocyanin accumulation, and abnormal expression of several light-responsive genes, including CAB3, RBCS, CHS, and PORA, under both darkness and far-red light conditions. Anthocyanins 175-186 ATP binding cassette subfamily B19 Arabidopsis thaliana 32-38 15908594-3 2005 We showed that loss-of-function atmdr1 and atpgp1 mutants display hypersensitivity to far-red, red, and blue-light inhibition of hypocotyl elongation, reduced chlorophyll and anthocyanin accumulation, and abnormal expression of several light-responsive genes, including CAB3, RBCS, CHS, and PORA, under both darkness and far-red light conditions. Anthocyanins 175-186 ATP binding cassette subfamily B1 Arabidopsis thaliana 43-49 15769121-8 2005 These results indicate that polyphenols-induced vasorelaxation may also be sustained by smooth muscle PDE inhibition by anthocyanins present in red wines and grapes. Anthocyanins 120-132 aldehyde dehydrogenase 7 family member A1 Homo sapiens 102-105 15894620-3 2005 T-DNA insertional mutated alleles of AtSIZ1 (At5g60410) cause Arabidopsis to exhibit exaggerated prototypical Pi starvation responses, including cessation of primary root growth, extensive lateral root and root hair development, increase in root/shoot mass ratio, and greater anthocyanin accumulation, even though intracellular Pi levels in siz1 plants were similar to wild type. Anthocyanins 276-287 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 37-43 15997850-5 2005 At 100 ppm, anthocyanin mixtures from the three species inhibited cyclo-oxygenase (COX)-1 and -2 enzymes at 66 and 67%, 60 and 72%, and 51 and 76%, respectively. Anthocyanins 12-23 COX1 Branta canadensis 66-96 15863361-4 2005 In this study, we have shown for the first time the gene expression profile in isolated rat adipocytes treated with anthocyanins (cyanidin 3-glucoside; C3G or cyanidin; Cy). Anthocyanins 116-128 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 152-155 15807784-4 2005 This combined analysis revealed the specific accumulation of cyanidin and quercetin derivatives, and identified eight novel anthocyanins from an array of putative 1800 metabolites in PAP1 over-expressing plants. Anthocyanins 124-136 phosphatidic acid phosphatase 1 Arabidopsis thaliana 183-187 15807784-7 2005 Two putative glycosyltransferase genes (At5g17050 and At4g14090) induced by PAP1 expression were confirmed to encode flavonoid 3-O-glucosyltransferase and anthocyanin 5-O-glucosyltransferase, respectively, from the enzymatic activity of their recombinant proteins in vitro and results of the analysis of anthocyanins in the respective T-DNA-inserted mutants. Anthocyanins 304-316 phosphatidic acid phosphatase 1 Arabidopsis thaliana 76-80 15608338-4 2005 Plants with even moderately reduced ACL activity have a complex, bonsai phenotype, with miniaturized organs, smaller cells, aberrant plastid morphology, reduced cuticular wax deposition, and hyperaccumulation of starch, anthocyanin, and stress-related mRNAs in vegetative tissue. Anthocyanins 220-231 acetone-cyanohydrin lyase Arabidopsis thaliana 36-39 15740068-0 2005 Induction of apoptosis by the Anthocyanidins through regulation of Bcl-2 gene and activation of c-Jun N-terminal kinase cascade in hepatoma cells. Anthocyanins 30-44 BCL2 apoptosis regulator Homo sapiens 67-72 15740068-0 2005 Induction of apoptosis by the Anthocyanidins through regulation of Bcl-2 gene and activation of c-Jun N-terminal kinase cascade in hepatoma cells. Anthocyanins 30-44 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 96-101 15695592-9 2005 The endothelial cells in aha10 mutants are otherwise healthy, as indicated by the lack of a significant decrease in (i) the accumulation of other flavonoid pathway end products, such as anthocyanins, and (ii) mRNA levels for two endothelium-specific transcripts (TT12 and BAN). Anthocyanins 186-198 autoinhibited H[+]-ATPase Arabidopsis thaliana 25-30 15703998-4 2005 These data point to a possible role of bilitranslocase and of its food-borne substrates (anthocyanins and nicotinic acid) in regulating the function and the permeability of the gastric mucosa. Anthocyanins 89-101 ceruloplasmin Rattus norvegicus 39-54 15455341-0 2005 Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Anthocyanins 0-11 CD1 antigen complex Mus musculus 141-145 15631504-0 2005 Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. Anthocyanins 31-43 insulin Homo sapiens 0-7 15631504-0 2005 Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. Anthocyanins 48-62 insulin Homo sapiens 0-7 15631504-5 2005 Our results indicated that 1 and 2 were the most effective insulin secretagogues among the anthocyanins and anthocyanidins tested at 4 and 10 mM glucose concentrations. Anthocyanins 91-103 insulin Homo sapiens 59-66 15631504-5 2005 Our results indicated that 1 and 2 were the most effective insulin secretagogues among the anthocyanins and anthocyanidins tested at 4 and 10 mM glucose concentrations. Anthocyanins 108-122 insulin Homo sapiens 59-66 15631504-7 2005 The rest of the anthocyanins and anthocyanidins tested in our assay had only marginal effects on insulin at 4 and 10 mM glucose concentrations. Anthocyanins 33-47 insulin Homo sapiens 97-104 15618424-5 2005 Tomato CRY2 overexpressors show phenotypes similar to but distinct from their Arabidopsis counterparts (hypocotyl and internode shortening under both low- and high-fluence blue light), but also several novel ones, including a high-pigment phenotype, resulting in overproduction of anthocyanins and chlorophyll in leaves and of flavonoids and lycopene in fruits. Anthocyanins 281-293 cryptochrome 2 Arabidopsis thaliana 7-11 15618424-8 2005 Virus-induced gene silencing of CRY2 results in a reversion of leaf anthocyanin accumulation, of internode shortening, and of late flowering in CRY2-overexpressing plants, whereas in wild-type plants it causes a minor internode elongation. Anthocyanins 68-79 cryptochrome 2 Arabidopsis thaliana 32-36 15451888-1 2004 Great attention has been recently given to a flavonoid of the anthocyanin class, cyanidin-3-O-beta-glucopyranoside (C-3-G), which is widely spread throughout the plant kingdom, and is present in both fruits and vegetables of human diets. Anthocyanins 62-73 Rap guanine nucleotide exchange factor 1 Homo sapiens 116-121 15821869-5 2005 Both these genes also complemented the anthocyanin defect in a white-flowered Matthiola incana ttg1 mutant. Anthocyanins 39-50 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 95-99 15096096-2 2004 In the present study, F3H (flavanone 3-hydroxylase), a key enzyme in the flavonoid biosynthetic pathway that participates in the formation of red-coloured anthocyanins, was used as a target for RNase P-mediated gene disruption in maize cells. Anthocyanins 155-167 Flavanone 3-dioxygenase 1 Zea mays 22-50 17147621-2 2004 PAP1, a member of the family of MYB domain transcription factors in Arabidopsis, is a positive regulator of the biosynthesis of anthocyanin. Anthocyanins 128-139 phosphatidic acid phosphatase 1 Arabidopsis thaliana 0-4 17147621-5 2004 Our results indicate that PAP1 has the potential ability to regulate the biosynthesis not only of anthocyanin but also of proanthocyanidin. Anthocyanins 98-109 phosphatidic acid phosphatase 1 Arabidopsis thaliana 26-30 15497183-1 2004 The aglycons of the most abundant anthocyanins in food, cyanidin (cy) and delphinidin (del), represent potent inhibitors of the epidermal growth factor receptor (EGFR). Anthocyanins 34-46 epidermal growth factor receptor Homo sapiens 128-160 15497183-1 2004 The aglycons of the most abundant anthocyanins in food, cyanidin (cy) and delphinidin (del), represent potent inhibitors of the epidermal growth factor receptor (EGFR). Anthocyanins 34-46 epidermal growth factor receptor Homo sapiens 162-166 15497183-9 2004 This is consistent with the finding that efficient reduction of cell growth is limited to anthocyanidins that are potent EGFR- or PDE-inhibitors including cy and del or malvidin (mv), respectively. Anthocyanins 90-104 epidermal growth factor receptor Homo sapiens 121-125 15497183-9 2004 This is consistent with the finding that efficient reduction of cell growth is limited to anthocyanidins that are potent EGFR- or PDE-inhibitors including cy and del or malvidin (mv), respectively. Anthocyanins 90-104 aldehyde dehydrogenase 7 family member A1 Homo sapiens 130-133 15368665-3 2004 Here we have investigated the therapeutic efficacy of anthocyanins contained in a blackberry extract on (i) circulatory failure, (ii), multiple organ dysfunction and (iii) activity of the inducible isoforms of nitric oxide (NO) synthase (iNOS) and cyclooxygenase (COX-2) in anaesthetised rats with endotoxic shock. Anthocyanins 54-66 nitric oxide synthase 2 Rattus norvegicus 238-242 15368665-3 2004 Here we have investigated the therapeutic efficacy of anthocyanins contained in a blackberry extract on (i) circulatory failure, (ii), multiple organ dysfunction and (iii) activity of the inducible isoforms of nitric oxide (NO) synthase (iNOS) and cyclooxygenase (COX-2) in anaesthetised rats with endotoxic shock. Anthocyanins 54-66 cytochrome c oxidase II, mitochondrial Rattus norvegicus 264-269 15368665-8 2004 Endotoxaemia for 6 h resulted in a substantial increase in iNOS and COX activity in rat lung, which was attenuated in rats pretreated with anthocyanins. Anthocyanins 139-151 nitric oxide synthase 2 Rattus norvegicus 59-63 15368665-9 2004 Moreover, anthocyanins (0.02 - 0.32 mg/mL) inhibited in vitro iNOS and COX activity from lung of LPS-treated rats. Anthocyanins 10-22 nitric oxide synthase 2 Rattus norvegicus 62-66 15208386-7 2004 This appears to reflect the presence of a second, highly homologous gene, ZmMrp4, that is also coregulated with the anthocyanin pathway but is expressed exclusively in aleurone tissue. Anthocyanins 116-127 ABC transporter C family MRP4 Zea mays 74-80 15096096-3 2004 Transient expression of an EGS complementary to the F3H mRNA resulted in suppression of F3H to 29% of the control, as indicated by a reduced number of anthocyanin-accumulating cells. Anthocyanins 151-162 Flavanone 3-dioxygenase 1 Zea mays 52-55 15030206-3 2004 The single-gene overexpression or simultaneous expression of genes encoding chalcone synthase (CHS), chalcone isomerase (CHI), and dihydroflavonol reductase (DFR) resulted in a significant increase of measured phenolic acids and anthocyanins. Anthocyanins 229-241 dihydroflavonol-4-reductase Solanum tuberosum 131-156 15161201-6 2004 However, anthocyanins and to a lesser extent vitisins exhibited protective effects against TNF-alpha-induced monocyte chemoattractant protein production in primary human endothelial cells. Anthocyanins 9-21 tumor necrosis factor Homo sapiens 91-100 15003523-4 2004 Treated adipocytes with anthocyanins enhanced adipocytokine (adiponectin and leptin) secretion and up-regulated the adipocyte specific gene expression without activation of PPARgamma in isolated rat adipocytes. Anthocyanins 24-36 adiponectin, C1Q and collagen domain containing Rattus norvegicus 61-72 15003523-4 2004 Treated adipocytes with anthocyanins enhanced adipocytokine (adiponectin and leptin) secretion and up-regulated the adipocyte specific gene expression without activation of PPARgamma in isolated rat adipocytes. Anthocyanins 24-36 leptin Rattus norvegicus 77-83 15003523-5 2004 The gene expression of adiponectin was also up-regulated in white adipose tissue in mice fed an anthocyanin supplemented diet. Anthocyanins 96-107 adiponectin, C1Q and collagen domain containing Mus musculus 23-34 15030206-3 2004 The single-gene overexpression or simultaneous expression of genes encoding chalcone synthase (CHS), chalcone isomerase (CHI), and dihydroflavonol reductase (DFR) resulted in a significant increase of measured phenolic acids and anthocyanins. Anthocyanins 229-241 dihydroflavonol-4-reductase Solanum tuberosum 158-161 15004287-1 2004 MYB-related proteins play a key role in regulating the biosynthesis of anthocyanins in plants at the transcriptional level. Anthocyanins 71-83 myb-related protein 3R-1-like Nicotiana tabacum 0-3 14996215-5 2004 The sensitivity and amplitude of metabolic Pi-starvation responses, such as Pi-responsive gene expression or accumulation of anthocyanins and starch, are enhanced in pdr2 seedlings. Anthocyanins 125-137 phosphate deficiency response 2 Arabidopsis thaliana 166-170 14718498-1 2004 DFR is involved in an important step in the flavonoid biosynthesis pathway upstream of anthocyanin, proanthocyanidin, and phlobaphene production, which contributes to the pigmentation of various plant tissues. Anthocyanins 87-98 DFR Triticum aestivum 0-3 14976232-1 2004 Dihydroflavonol-4-reductase (DFR; EC1.1.1.219) catalyzes a key step late in the biosynthesis of anthocyanins, condensed tannins (proanthocyanidins), and other flavonoids important to plant survival and human nutrition. Anthocyanins 96-108 dihydroflavonol 4-reductase Medicago truncatula 0-27 14742877-6 2004 Subsequent duplications within each clade have led to additional WD40 repeat proteins in particular species, with all mutants defective in anthocyanin expression contained in the PAC1 clade. Anthocyanins 139-150 pale aleurone color 1 Zea mays 179-183 15015712-11 2003 Furthermore, the inhibition by apyrase and the increase by ecto-ATPase inhibition of the GSP- and anthocyanin-induced relaxation suggest that these substances could act via an initial release of nucleotides, which in turn could activate P2Y1 and/or P2Y2 purinoceptors of endothelial cells, trigger the synthesis and release of NO and then lead to relaxation. Anthocyanins 98-109 CEA cell adhesion molecule 1 Rattus norvegicus 59-70 14675436-0 2004 TRANSPARENT TESTA 19 is involved in the accumulation of both anthocyanins and proanthocyanidins in Arabidopsis. Anthocyanins 61-73 glutathione S-transferase phi 12 Arabidopsis thaliana 12-20 14675436-4 2004 Novel Arabidopsis mutants, transparent testa 19 (tt19), which were induced by ion beam irradiation, showed a great reduction of anthocyanin pigments in the vegetative parts as well as brown pigments in the seed coat. Anthocyanins 128-139 glutathione S-transferase phi 12 Arabidopsis thaliana 39-47 14675436-4 2004 Novel Arabidopsis mutants, transparent testa 19 (tt19), which were induced by ion beam irradiation, showed a great reduction of anthocyanin pigments in the vegetative parts as well as brown pigments in the seed coat. Anthocyanins 128-139 glutathione S-transferase phi 12 Arabidopsis thaliana 49-53 14675436-6 2004 Heterologous expression of a putative ortholog, petunia anthocyanin 9 (AN9), in tt19 complemented the anthocyanin accumulation but not the brown pigmentation in the seed coat. Anthocyanins 56-67 glutathione S-transferase phi 12 Arabidopsis thaliana 80-84 14675436-7 2004 This suggests that the TT19 gene is required for vacuolar uptake of anthocyanins into vacuoles, but that it has also a function different from that of AN9. Anthocyanins 68-80 glutathione S-transferase phi 12 Arabidopsis thaliana 23-27 14690384-3 2003 In matured wine, anthocyanins are transformed to anthocyanin-vinyl derivatives, ethyl bridged anthocyanin-flavanol adducts, and anthocyanin-flavanol adducts. Anthocyanins 17-29 DDB1 and CUL4 associated factor 7 Homo sapiens 49-60 14690384-3 2003 In matured wine, anthocyanins are transformed to anthocyanin-vinyl derivatives, ethyl bridged anthocyanin-flavanol adducts, and anthocyanin-flavanol adducts. Anthocyanins 17-29 DDB1 and CUL4 associated factor 7 Homo sapiens 49-60 14745173-3 2004 Lipopolysaccharide (LPS)-induced TNF-alpha production from macrophages was inhibited by treatment with flavone (luteolin, apigenin, and chrysin), flavonol (quercetin and myricetin), flavanonol (taxifolin), and anthocyanidin (cyanidin chloride) in vitro. Anthocyanins 210-223 tumor necrosis factor Mus musculus 33-42 14514663-8 2004 Those results demonstrate that anthocyanidins contribute to the inhibition of tumorigenesis by blocking activation of the MAPK pathway. Anthocyanins 31-45 mitogen-activated protein kinase 1 Homo sapiens 122-126 15015712-11 2003 Furthermore, the inhibition by apyrase and the increase by ecto-ATPase inhibition of the GSP- and anthocyanin-induced relaxation suggest that these substances could act via an initial release of nucleotides, which in turn could activate P2Y1 and/or P2Y2 purinoceptors of endothelial cells, trigger the synthesis and release of NO and then lead to relaxation. Anthocyanins 98-109 purinergic receptor P2Y1 Rattus norvegicus 237-241 15015712-11 2003 Furthermore, the inhibition by apyrase and the increase by ecto-ATPase inhibition of the GSP- and anthocyanin-induced relaxation suggest that these substances could act via an initial release of nucleotides, which in turn could activate P2Y1 and/or P2Y2 purinoceptors of endothelial cells, trigger the synthesis and release of NO and then lead to relaxation. Anthocyanins 98-109 purinergic receptor P2Y2 Rattus norvegicus 249-253 13679981-1 2003 We have recently identified an allele of dihydroflavonol 4-reductase ( dfr) that cosegregates with the ability of potato ( Solanum tuberosum L) to produce red pelargonidin-based anthocyanin pigments. Anthocyanins 178-189 dihydroflavonol 4-reductase Solanum tuberosum 41-68 13679981-1 2003 We have recently identified an allele of dihydroflavonol 4-reductase ( dfr) that cosegregates with the ability of potato ( Solanum tuberosum L) to produce red pelargonidin-based anthocyanin pigments. Anthocyanins 178-189 dihydroflavonol 4-reductase Solanum tuberosum 71-74 12940955-1 2003 The anthocyanin and proanthocyanidin (PA) biosynthetic pathways share common intermediates until leucocyanidin, which may be used by leucoanthocyanidin dioxygenase (LDOX) to produce anthocyanin, or the enzyme leucoanthocyanidin reductase (LAR) to produce catechin, a precursor of PA. Anthocyanins 4-15 leucoanthocyanidin dioxygenase Arabidopsis thaliana 133-163 12917293-6 2003 The double bHLH mutant, gl3 egl3, has a pleiotropic phenotype like ttg1 having defective anthocyanin production, seed coat mucilage production, and position-dependent root hair spacing. Anthocyanins 89-100 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 24-27 12917293-6 2003 The double bHLH mutant, gl3 egl3, has a pleiotropic phenotype like ttg1 having defective anthocyanin production, seed coat mucilage production, and position-dependent root hair spacing. Anthocyanins 89-100 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 67-71 12888907-8 2003 Thus, anthocyanidins may trigger an apoptotic death program through an oxidative stress-involved JNK signaling pathway. Anthocyanins 6-20 mitogen-activated protein kinase 8 Homo sapiens 97-100 12940955-1 2003 The anthocyanin and proanthocyanidin (PA) biosynthetic pathways share common intermediates until leucocyanidin, which may be used by leucoanthocyanidin dioxygenase (LDOX) to produce anthocyanin, or the enzyme leucoanthocyanidin reductase (LAR) to produce catechin, a precursor of PA. Anthocyanins 4-15 leucoanthocyanidin dioxygenase Arabidopsis thaliana 165-169 12940955-1 2003 The anthocyanin and proanthocyanidin (PA) biosynthetic pathways share common intermediates until leucocyanidin, which may be used by leucoanthocyanidin dioxygenase (LDOX) to produce anthocyanin, or the enzyme leucoanthocyanidin reductase (LAR) to produce catechin, a precursor of PA. Anthocyanins 182-193 leucoanthocyanidin dioxygenase Arabidopsis thaliana 133-163 12940955-1 2003 The anthocyanin and proanthocyanidin (PA) biosynthetic pathways share common intermediates until leucocyanidin, which may be used by leucoanthocyanidin dioxygenase (LDOX) to produce anthocyanin, or the enzyme leucoanthocyanidin reductase (LAR) to produce catechin, a precursor of PA. Anthocyanins 182-193 leucoanthocyanidin dioxygenase Arabidopsis thaliana 165-169 12940955-11 2003 These results show that in addition to its established role in the formation of anthocyanin, LDOX is also part of the PA biosynthesis pathway. Anthocyanins 80-91 leucoanthocyanidin dioxygenase Arabidopsis thaliana 93-97 14756308-0 2003 Post-transcriptional regulation of expression of the Bronze2 gene of Zea mays L. The glutathione S-transferase encoded by Bronze2 performs the last genetically defined step in maize anthocyanin biosynthesis, being required for pigment sequestration into vacuoles. Anthocyanins 182-193 glutathione S-transferase Zea mays 53-60 14756308-0 2003 Post-transcriptional regulation of expression of the Bronze2 gene of Zea mays L. The glutathione S-transferase encoded by Bronze2 performs the last genetically defined step in maize anthocyanin biosynthesis, being required for pigment sequestration into vacuoles. Anthocyanins 182-193 glutathione S-transferase Zea mays 122-129 12897245-2 2003 One of the activation-tagged insertion lines (ant1) showed intense purple pigmentation from the very early stage of shoot formation in culture, reflecting activation of the biosynthetic pathway leading to anthocyanin accumulation. Anthocyanins 205-216 anthocyanin 1 Solanum lycopersicum 46-50 12897245-6 2003 Suppression subtractive hybridization and RNA hybridization analysis of the purple tomato plants indicated that the overexpression of ANT1 caused the upregulation of genes that encode proteins in both the early and later steps of anthocyanidin biosynthesis as well as genes involved in the glycosylation and transport of anthocyanins into the vacuole. Anthocyanins 230-243 anthocyanin 1 Solanum lycopersicum 134-138 12897245-6 2003 Suppression subtractive hybridization and RNA hybridization analysis of the purple tomato plants indicated that the overexpression of ANT1 caused the upregulation of genes that encode proteins in both the early and later steps of anthocyanidin biosynthesis as well as genes involved in the glycosylation and transport of anthocyanins into the vacuole. Anthocyanins 321-333 anthocyanin 1 Solanum lycopersicum 134-138 12769524-2 2003 This study examined the effect of four anthocyanins in black currant fruits on the regeneration of rhodopsin using frog rod outer segment (ROS) membranes. Anthocyanins 39-51 rhodopsin Homo sapiens 99-108 12769524-6 2003 It was concluded that the major effect of anthocyanins in rod photoreceptors is on the regeneration of rhodopsin. Anthocyanins 42-54 rhodopsin Homo sapiens 103-112 12956536-0 2003 Two basic-helix-loop-helix genes (MYC-146 and GL3) from Arabidopsis can activate anthocyanin biosynthesis in a white-flowered Matthiola incana mutant. Anthocyanins 81-92 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 34-49 12956536-1 2003 Basic helix-loop-helix (bHLH) proteins, similar to mammalian Myc transcription factors, regulate the anthocyanin biosynthetic pathway in both monocots and dicots. Anthocyanins 101-112 MYC proto-oncogene, bHLH transcription factor Homo sapiens 61-64 12956536-2 2003 Two Arabidopsis bHLH genes, GLABRA3 (GL3) and MYC-146, encode proteins that are similar throughout the predicted amino acid sequence to R and DELILA, which regulate anthocyanin production in maize and snapdragon, respectively. Anthocyanins 165-176 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 28-35 12956536-2 2003 Two Arabidopsis bHLH genes, GLABRA3 (GL3) and MYC-146, encode proteins that are similar throughout the predicted amino acid sequence to R and DELILA, which regulate anthocyanin production in maize and snapdragon, respectively. Anthocyanins 165-176 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 37-40 12956536-2 2003 Two Arabidopsis bHLH genes, GLABRA3 (GL3) and MYC-146, encode proteins that are similar throughout the predicted amino acid sequence to R and DELILA, which regulate anthocyanin production in maize and snapdragon, respectively. Anthocyanins 165-176 MYC proto-oncogene, bHLH transcription factor Homo sapiens 46-49 12956536-6 2003 The lack of anthocyanin-deficient Arabidopsis mutants mapping to the locations of GL3 and MYC-146 suggests that the two bHLH proteins may be partially redundant and overlap in function. Anthocyanins 12-23 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 82-85 12956536-6 2003 The lack of anthocyanin-deficient Arabidopsis mutants mapping to the locations of GL3 and MYC-146 suggests that the two bHLH proteins may be partially redundant and overlap in function. Anthocyanins 12-23 MYC proto-oncogene, bHLH transcription factor Homo sapiens 90-93 12532018-3 2003 We show that the BANYULS (BAN) genes from Arabidopsis thaliana and Medicago truncatula encode anthocyanidin reductase, which converts anthocyanidins to their corresponding 2,3-cis-flavan-3-ols. Anthocyanins 134-148 NAD(P)-binding Rossmann-fold superfamily protein Arabidopsis thaliana 17-24 12643652-1 2003 Two newly formed anthocyanin-derived pigments that revealed unique spectroscopic features, showing maximum absorption in their UV-vis spectra at 575 nm, were isolated by TSK Toyopearl HW-40 (S) gel column chromatography and semipreparative HPLC from an aged Port red wine. Anthocyanins 17-28 tsukushi, small leucine rich proteoglycan Homo sapiens 170-173 12532018-3 2003 We show that the BANYULS (BAN) genes from Arabidopsis thaliana and Medicago truncatula encode anthocyanidin reductase, which converts anthocyanidins to their corresponding 2,3-cis-flavan-3-ols. Anthocyanins 134-148 NAD(P)-binding Rossmann-fold superfamily protein Arabidopsis thaliana 17-20 12532018-4 2003 Ectopic expression of BAN in tobacco flower petals and Arabidopsis leaves results in loss of anthocyanins and accumulation of CTs. Anthocyanins 93-105 NAD(P)-binding Rossmann-fold superfamily protein Arabidopsis thaliana 22-25 12833179-6 2003 Administering anthocyanins with cadmium chloride resulted in a statistically significant decrease of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, concentration of bilirubin and urea in blood serum and decreased cadmium cumulation in liver and kidneys in relation to animals receiving cadmium chloride only. Anthocyanins 14-26 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 101-127 12833179-6 2003 Administering anthocyanins with cadmium chloride resulted in a statistically significant decrease of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, concentration of bilirubin and urea in blood serum and decreased cadmium cumulation in liver and kidneys in relation to animals receiving cadmium chloride only. Anthocyanins 14-26 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 129-132 12384577-6 2002 Introduction of IFS into the tt6/tt3 double mutant blocked in flavonol, and anthocyanin synthesis resulted in high levels of genistein. Anthocyanins 76-87 isoflavone synthase 1 Glycine max 16-19 11553733-2 2001 The TT4, TT5, and TT3 loci encode chalcone synthase, chalcone isomerase, and dihydroflavonol 4-reductase, respectively, which are essential for anthocyanin accumulation and may form a macromolecular complex. Anthocyanins 144-155 Chalcone and stilbene synthase family protein Arabidopsis thaliana 4-7 12489822-2 2002 We have demonstrated that a typical anthocyanin, cyanidin 3-O-beta-D-glucoside (C3G), suppressed the zymosan-induced inflammatory response in rats when it was orally administered. Anthocyanins 36-47 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 80-83 12015158-3 2002 In this regard we investigated the putative antioxidant and anti-inflammatory effects of blueberry and cranberry anthocyanins and hydroxycinnamic acids against H(2)O(2) and TNFalpha induced damage to human microvascular endothelial cells. Anthocyanins 113-125 tumor necrosis factor Homo sapiens 173-181 11796114-2 2002 Anthocyanidin synthase (ANS), a 2-oxoglutarate iron-dependent oxygenase, catalyzes the penultimate step in the biosynthesis of the anthocyanin class of flavonoids. Anthocyanins 131-142 leucoanthocyanidin dioxygenase Arabidopsis thaliana 0-22 11743123-8 2001 The leaves of ram1 plants accumulate wild-type levels of starch, soluble sugars, anthocyanin, and chlorophyll. Anthocyanins 81-92 beta-amylase 5 Arabidopsis thaliana 14-18 11675493-3 2001 The starting point for this study was P instability factor (PIF), an active DNA transposable element family from maize that was first identified following multiple mutagenic insertions into exactly the same site in intron 2 of the maize anthocyanin regulatory gene R. In this study we report the isolation of a maize Tourist-like MITE family called miniature PIF (mPIF) that shares several features with PIF elements, including identical terminal inverted repeats, similar subterminal sequences, and an unusual but striking preference for an extended 9-bp target site. Anthocyanins 237-248 Pif Mus musculus 60-63 12244439-9 2002 spa1 mutations also enhanced the HIRs of anthocyanin accumulation and of phyA-mediated responsivity amplification towards phyB. Anthocyanins 41-52 SPA (suppressor of phyA-105) protein family Arabidopsis thaliana 0-4 12188603-1 2002 The antioxidant activity of nine anthocyanin glycosides was measured in a neutral pH region using a chemiluminescence (CL) emission system in the presence of an H(2)O(2)-acetaldehyde system, and the intensities were found to be affected by three factors, pH value and both moieties of the aglycon and C-3 sugar. Anthocyanins 33-55 complement C3 Homo sapiens 301-304 12105943-0 2002 Effects of anthocyanins and other phenolic compounds on the production of tumor necrosis factor alpha in LPS/IFN-gamma-activated RAW 264.7 macrophages. Anthocyanins 11-23 tumor necrosis factor Homo sapiens 74-101 12105943-0 2002 Effects of anthocyanins and other phenolic compounds on the production of tumor necrosis factor alpha in LPS/IFN-gamma-activated RAW 264.7 macrophages. Anthocyanins 11-23 interferon gamma Homo sapiens 109-118 12105943-2 2002 Common phenolic compounds, including phenolic acids, flavonols, isoflavones, and anthocyanins, present in fruits, vegetables, and grains were investigated for their effects on the production of tumor necrosis factor alpha (TNF-alpha) in LPS/IFN-gamma-activated RAW 264.7 macrophages. Anthocyanins 81-93 tumor necrosis factor Homo sapiens 194-221 12105943-2 2002 Common phenolic compounds, including phenolic acids, flavonols, isoflavones, and anthocyanins, present in fruits, vegetables, and grains were investigated for their effects on the production of tumor necrosis factor alpha (TNF-alpha) in LPS/IFN-gamma-activated RAW 264.7 macrophages. Anthocyanins 81-93 tumor necrosis factor Homo sapiens 223-232 12105943-7 2002 Anthocyanidins/anthocyanins and anthocyanin-rich extracts induced TNF-alpha production and acted as modulators of the immune response in activated macrophages. Anthocyanins 0-14 tumor necrosis factor Homo sapiens 66-75 12105943-7 2002 Anthocyanidins/anthocyanins and anthocyanin-rich extracts induced TNF-alpha production and acted as modulators of the immune response in activated macrophages. Anthocyanins 15-27 tumor necrosis factor Homo sapiens 66-75 12105943-7 2002 Anthocyanidins/anthocyanins and anthocyanin-rich extracts induced TNF-alpha production and acted as modulators of the immune response in activated macrophages. Anthocyanins 15-26 tumor necrosis factor Homo sapiens 66-75 12105943-8 2002 This is the first study to report the effects of anthocyanins and berry extracts on TNF-alpha production. Anthocyanins 49-61 tumor necrosis factor Homo sapiens 84-93 11975729-5 2002 Anthocyanin concentration of aster "Sungal" flowers grown at 29 degrees C/21 degrees C day/night, respectively, was about half that of flowers grown at 17 degrees C/9 degrees C. The activity of phenylalanine ammonia-lyase (PAL) and chalcone isomerase (CHI) decreased as the temperature increased. Anthocyanins 0-11 peptidylglycine alpha-amidating monooxygenase Homo sapiens 194-221 11829656-0 2002 Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW 264.7 macrophages. Anthocyanins 22-34 interferon gamma Homo sapiens 98-107 12240335-0 2001 Evidence for oxidation at C-3 of the flavonoid C-ring during anthocyanin biosynthesis. Anthocyanins 61-72 complement C3 Homo sapiens 26-29 11834210-4 2001 Subsequently, we demonstrate that fractions containing anthocyanins lower ROS (reactive oxygen species) and methemoglobin production in human erythrocytes treated with H(2)O(2.) Anthocyanins 55-67 hemoglobin subunit gamma 2 Homo sapiens 108-121 11834210-5 2001 Finally, we reported that the protective effects of anthocyanins were also confirmed in an experimental model in which RBCs were deprived of catalase activity by treatment with 4 mM sodium azide. Anthocyanins 52-64 catalase Homo sapiens 141-149 11553733-2 2001 The TT4, TT5, and TT3 loci encode chalcone synthase, chalcone isomerase, and dihydroflavonol 4-reductase, respectively, which are essential for anthocyanin accumulation and may form a macromolecular complex. Anthocyanins 144-155 Chalcone-flavanone isomerase family protein Arabidopsis thaliana 9-12 11553733-2 2001 The TT4, TT5, and TT3 loci encode chalcone synthase, chalcone isomerase, and dihydroflavonol 4-reductase, respectively, which are essential for anthocyanin accumulation and may form a macromolecular complex. Anthocyanins 144-155 dihydroflavonol 4-reductase Arabidopsis thaliana 18-21 11553733-2 2001 The TT4, TT5, and TT3 loci encode chalcone synthase, chalcone isomerase, and dihydroflavonol 4-reductase, respectively, which are essential for anthocyanin accumulation and may form a macromolecular complex. Anthocyanins 144-155 dihydroflavonol 4-reductase Arabidopsis thaliana 77-104 11511543-3 2001 One of the mutants, phr1 (phosphate starvation response 1), displayed reduced response of AtIPS1::GUS to Pi starvation, and also had a broad range of Pi starvation responses impaired, including the responsiveness of various other Pi starvation-induced genes and metabolic responses, such as the increase in anthocyanin accumulation. Anthocyanins 307-318 uncharacterized protein Chlamydomonas reinhardtii 20-24 11532176-5 2001 In addition, AtGSK1 transgenic plants in the absence of NaCl stress showed phenotypic changes, such as accumulation of anthocyanin, that were similar to those observed in wild-type plants under NaCl stress. Anthocyanins 119-130 GSK3/SHAGGY-like protein kinase 1 Arabidopsis thaliana 13-19 11316805-1 2001 In the conversion from colorless leucoanthocyanidin to colored anthocyanidin 3-glucoside, at least two enzymes, anthocyanidin synthase (ANS) and UDP-glucose:flavonoid 3-O-glucosyltransferase (3-GT), are postulated to be involved. Anthocyanins 33-51 anthocyanidin 3-O-glucosyltransferase Zea mays 145-190 11312894-2 2001 In a rat study, following oral administration of purified D3R, C3R, and C3G (800 micromol/kg of body weight), the anthocyanins were detected in the plasma and the C(max) values were 580 +/- 410, 850 +/- 120, and 840 +/- 190 nmol/L, respectively, 0.5-2.0 h after administration. Anthocyanins 114-126 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 72-75 11340179-3 2001 One mutant, named constitutive expression of VSP1 (cev1), produced plants that were smaller than wild type, had stunted roots with long root hairs, accumulated anthocyanin, had constitutive expression of the defense-related genes VSP1, VSP2, Thi2.1, PDF1.2, and CHI-B, and had enhanced resistance to powdery mildew diseases. Anthocyanins 160-171 vegetative storage protein 1 Arabidopsis thaliana 45-49 11340179-3 2001 One mutant, named constitutive expression of VSP1 (cev1), produced plants that were smaller than wild type, had stunted roots with long root hairs, accumulated anthocyanin, had constitutive expression of the defense-related genes VSP1, VSP2, Thi2.1, PDF1.2, and CHI-B, and had enhanced resistance to powdery mildew diseases. Anthocyanins 160-171 Cellulose synthase family protein Arabidopsis thaliana 51-55 11340186-9 2001 These results are consistent with photosynthate being trapped within anthocyanin-accumulating regions of sxd1 leaves due to plasmodesmal occlusion at the bundle sheath-vascular parenchyma boundary of the minor veins. Anthocyanins 69-80 tocopherol cyclase, chloroplastic Zea mays 105-109 11166442-1 2001 The expression of the UDP-glucose:flavonoid 3-O-glucosyltransferase (UFGT) gene has been shown to be critical for anthocyanin biosynthesis in the grape berry. Anthocyanins 114-125 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 22-67 11166442-1 2001 The expression of the UDP-glucose:flavonoid 3-O-glucosyltransferase (UFGT) gene has been shown to be critical for anthocyanin biosynthesis in the grape berry. Anthocyanins 114-125 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 69-73 12094617-4 2001 In the estrogen receptor-positive cell line MCF-7, the anthocyanidins induced expression of a reporter gene. Anthocyanins 55-69 estrogen receptor 1 Homo sapiens 7-24 11262056-6 2001 In intact cells the influence of anthocyanin treatment on downstream signaling cascades was investigated by measuring the phosphorylation of the transcription factor Elk-1. Anthocyanins 33-44 ETS transcription factor ELK1 Homo sapiens 166-171 11262056-9 2001 Thus, the anthocyanidins cy and del are potent inhibitors of the EGFR, shutting off downstream signaling cascades. Anthocyanins 10-24 epidermal growth factor receptor Homo sapiens 65-69 11161059-7 2001 In addition to seedling growth, accumulation of anthocyanins in FR, another manifestation of the high irradiance response, was strongly influenced by phyB holoprotein. Anthocyanins 48-60 phytochrome B Arabidopsis thaliana 150-154 12094622-2 2001 Very few data are available concerning the effects of anthocyanidins/anthocyanins on cellular processes induced by growth factors such as neurotensin and epidermal growth factor (EGF), which are implicated in the pathophysiology of colon cancer. Anthocyanins 54-68 neurotensin Homo sapiens 138-149 12094622-2 2001 Very few data are available concerning the effects of anthocyanidins/anthocyanins on cellular processes induced by growth factors such as neurotensin and epidermal growth factor (EGF), which are implicated in the pathophysiology of colon cancer. Anthocyanins 54-68 epidermal growth factor Homo sapiens 154-177 12094622-2 2001 Very few data are available concerning the effects of anthocyanidins/anthocyanins on cellular processes induced by growth factors such as neurotensin and epidermal growth factor (EGF), which are implicated in the pathophysiology of colon cancer. Anthocyanins 54-68 epidermal growth factor Homo sapiens 179-182 12094622-2 2001 Very few data are available concerning the effects of anthocyanidins/anthocyanins on cellular processes induced by growth factors such as neurotensin and epidermal growth factor (EGF), which are implicated in the pathophysiology of colon cancer. Anthocyanins 69-81 neurotensin Homo sapiens 138-149 12094622-2 2001 Very few data are available concerning the effects of anthocyanidins/anthocyanins on cellular processes induced by growth factors such as neurotensin and epidermal growth factor (EGF), which are implicated in the pathophysiology of colon cancer. Anthocyanins 69-81 epidermal growth factor Homo sapiens 154-177 12094622-2 2001 Very few data are available concerning the effects of anthocyanidins/anthocyanins on cellular processes induced by growth factors such as neurotensin and epidermal growth factor (EGF), which are implicated in the pathophysiology of colon cancer. Anthocyanins 69-81 epidermal growth factor Homo sapiens 179-182 11154335-2 2001 Comparative phenotypic and photobiological analyses of plastid- and cytosol-targeted BVR lines showed that multiple phytochrome-regulated processes, such as hypocotyl and internode elongation, anthocyanin synthesis, and photoperiodic regulation of flowering, were altered in all lines examined. Anthocyanins 193-204 biliverdin reductase A Homo sapiens 85-88 11135122-6 2000 Dihydroflavonol-4-reductase is an essential enzyme of the anthocyanin biosynthetic pathway in maize and barley. Anthocyanins 58-69 dihydroflavonol-4-reductase Zea mays 0-27 11135122-8 2000 In the presence of dsRNA corresponding to the dihydroflavonol-4-reductase gene, C1- and b-Peru-dependent, cell-autonomous accumulation of red anthocyanin pigments in bombarded cells of maize and barley was reduced. Anthocyanins 142-153 dihydroflavonol-4-reductase Zea mays 46-73 11063707-3 2000 The complex phenotype caused by ttg1 mutations is suppressed by ectopic expression of the maize anthocyanin regulator R. Here it is demonstrated that the Arabidopsis trichome development locus GLABRA3 (GL3) encodes an R homolog. Anthocyanins 96-107 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 32-36 11063707-3 2000 The complex phenotype caused by ttg1 mutations is suppressed by ectopic expression of the maize anthocyanin regulator R. Here it is demonstrated that the Arabidopsis trichome development locus GLABRA3 (GL3) encodes an R homolog. Anthocyanins 96-107 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 193-200 11063707-3 2000 The complex phenotype caused by ttg1 mutations is suppressed by ectopic expression of the maize anthocyanin regulator R. Here it is demonstrated that the Arabidopsis trichome development locus GLABRA3 (GL3) encodes an R homolog. Anthocyanins 96-107 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 202-205 11069708-6 2000 Irradiance response curves for anthocyanin synthesis revealed that phyB1 and phyB2 together mediate all the detectable response to high-irradiance R, and, surprisingly, that the phyA-dependent low-irradiance component is also strongly reduced in the phyB1 phyB2 double mutant. Anthocyanins 31-42 phytochrome B1 Solanum lycopersicum 67-72 11069708-6 2000 Irradiance response curves for anthocyanin synthesis revealed that phyB1 and phyB2 together mediate all the detectable response to high-irradiance R, and, surprisingly, that the phyA-dependent low-irradiance component is also strongly reduced in the phyB1 phyB2 double mutant. Anthocyanins 31-42 phytochrome B2 Solanum lycopersicum 77-82 10967916-1 2000 The administration of anthocyanin dyes from Aronia melanocarpa in the rats before the intraperitoneal injections of PAF and ceruleine have a beneficial effect on the development of the acute experimental pancreatitis. Anthocyanins 22-33 PCNA clamp associated factor Rattus norvegicus 116-119 11027726-7 2000 In a monocot cell system, introduced expression of a transcription factor regulating genes of the anthocyanin pathway was effective in conferring the ability to produce genistein in the presence of the IFS gene. Anthocyanins 98-109 isoflavone synthase 1 Glycine max 202-205 10993144-6 2000 An increase in the NADPH-cytochrome-P450-reductase activity in the liver microsome fraction by paraquat was suppressed by supplementing the paraquat diet with acylated anthocyanins. Anthocyanins 168-180 cytochrome p450 oxidoreductase Rattus norvegicus 19-50 11006336-1 2000 The petunia loci anthocyanin1 (an1), an2, an4, and an11 are required for the transcription of anthocyanin biosynthetic genes in floral organs. Anthocyanins 17-28 ent-copalyl diphosphate synthase 2, chloroplastic Zea mays 37-40 29345778-3 2000 On one hand, detection of malvidin-3-glucoside (Mv3g) among thiolysis products revealed the presence of anthocyanin-derived pigments in which Mv3g is linked by its C-6 or C-8 top. Anthocyanins 104-115 complement C6 Homo sapiens 164-167 29345778-3 2000 On one hand, detection of malvidin-3-glucoside (Mv3g) among thiolysis products revealed the presence of anthocyanin-derived pigments in which Mv3g is linked by its C-6 or C-8 top. Anthocyanins 104-115 homeobox C8 Homo sapiens 171-174 11237172-1 2000 Cyanidin 3-O-beta-D-glucoside (C3G) is included in anthocyanins, and expected to have a potency to scavenge active oxygen species in vivo. Anthocyanins 51-63 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 31-34 10746878-3 2000 We found that the phosphorylation of hexose by hexokinase, but not its transport, has to be taken into account for the sucrose signal transduction leading to anthocyanin accumulation. Anthocyanins 158-169 hexokinase Vitis vinifera 47-57 10746878-5 2000 Mannose mimics the effect of sucrose in grape cells, and mannoheptulose, a specific inhibitor of hexokinase, reduces the accumulation of anthocyanins in response to sucrose. Anthocyanins 137-149 hexokinase Vitis vinifera 97-107 30845571-8 1999 A single sh-2 hybrid exhibited red-purple leaf symptoms, probably as a result of a crossover between the anthocyanin production (a1) and sh-2 genes, which are linked about 0.25 map units apart on chromosome 3 (2). Anthocyanins 105-116 glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic/amyloplastic Zea mays 9-13 10504559-2 1999 Vp1 activation of the anthocyanin pathway exhibits strict cell autonomy in aleurone. Anthocyanins 22-33 regulatory protein viviparous-1 Zea mays 0-3 10552867-2 1999 Anthocyanins were semipurified by using a C-18 resin, washed with acidified water followed by ethyl acetate, and recovered with acidified methanol. Anthocyanins 0-12 Bardet-Biedl syndrome 9 Homo sapiens 42-46 10517855-3 1999 Regardless of its cellular localization, BVR suppresses the phytochrome-modulated responses of hypocotyl growth inhibition, sucrose-stimulated anthocyanin accumulation, and inhibition of floral initiation. Anthocyanins 143-154 biliverdin reductase A Homo sapiens 41-44 10338127-1 1999 We have clarified for the first time how cyanidin 3-O-beta-D-glucoside (C3G), which is a potent antioxidant anthocyanin, is absorbed and metabolized in vivo. Anthocyanins 108-119 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 72-75 10504561-1 1999 Mutations in the BANYULS (BAN) gene lead to precocious accumulation of anthocyanins in immature seed coat in Arabidopsis. Anthocyanins 71-83 NAD(P)-binding Rossmann-fold superfamily protein Arabidopsis thaliana 17-24 10402424-0 1999 ANTHOCYANINLESS2, a homeobox gene affecting anthocyanin distribution and root development in Arabidopsis. Anthocyanins 44-55 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein Arabidopsis thaliana 0-16 10402424-4 1999 Histological observations of the anl2 mutant revealed that the accumulation of anthocyanin was greatly suppressed in subepidermal cells but only slightly reduced in epidermal cells. Anthocyanins 79-90 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein Arabidopsis thaliana 33-37 10402424-6 1999 We discuss a possible role of ANL2 in the accumulation of anthocyanin and cellular organization of the primary root. Anthocyanins 58-69 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein Arabidopsis thaliana 30-34 10402433-0 1999 The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein. Anthocyanins 82-93 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 4-29 10402433-1 1999 The TRANSPARENT TESTA GLABRA1 (TTG1) locus regulates several developmental and biochemical pathways in Arabidopsis, including the formation of hairs on leaves, stems, and roots, and the production of seed mucilage and anthocyanin pigments. Anthocyanins 218-229 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 4-29 10402433-1 1999 The TRANSPARENT TESTA GLABRA1 (TTG1) locus regulates several developmental and biochemical pathways in Arabidopsis, including the formation of hairs on leaves, stems, and roots, and the production of seed mucilage and anthocyanin pigments. Anthocyanins 218-229 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 31-35 10402433-4 1999 The protein is similar to AN11, a regulator of anthocyanin biosynthesis in petunia, and more distantly related to those of the beta subunits of heterotrimeric G proteins, which suggests a role for TTG1 in signal transduction to downstream transcription factors. Anthocyanins 47-58 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 197-201 10101180-5 1999 Mutations in TTG are pleiotropic, affecting anthocyanins, root hairs, and seed coat mucilage in addition to trichomes. Anthocyanins 44-56 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 13-16 9489009-7 1998 This is in contrast to the reduced anthocyanin accumulation displayed by a mutant lacking the HY4 blue-light receptor, as hy4 displayed reduced expression of the above enzymes. Anthocyanins 35-46 cryptochrome 1 Arabidopsis thaliana 94-97 9878628-0 1999 A mutation in the pale aleurone color1 gene identifies a novel regulator of the maize anthocyanin pathway. Anthocyanins 86-97 pale aleurone color 1 Zea mays 18-38 9878628-1 1999 By screening for new seed color mutations, we have identified a new gene, pale aleurone color1 (pac1), which when mutated causes a reduction in anthocyanin pigmentation. Anthocyanins 144-155 pale aleurone color 1 Zea mays 74-94 9878628-1 1999 By screening for new seed color mutations, we have identified a new gene, pale aleurone color1 (pac1), which when mutated causes a reduction in anthocyanin pigmentation. Anthocyanins 144-155 pale aleurone color 1 Zea mays 96-100 9878628-6 1999 Introduction of an anthocyanin structural gene promoter (a1) driving a reporter gene into maize aleurones shows that pac1-ref kernels have reduced expression resulting from the action of the a1 promoter. Anthocyanins 19-30 pale aleurone color 1 Zea mays 117-121 9878628-8 1999 Our results imply that pac1 is required for either b/c1 or p activation of anthocyanin biosynthetic gene expression and that pac1 acts independently of these regulatory genes. Anthocyanins 75-86 pale aleurone color 1 Zea mays 23-27 9880376-1 1999 Antisense inhibition of RNS1 or RNS2 elevates anthocyanin accumulation. Anthocyanins 46-57 ribonuclease 1 Arabidopsis thaliana 24-28 9880376-1 1999 Antisense inhibition of RNS1 or RNS2 elevates anthocyanin accumulation. Anthocyanins 46-57 ribonuclease 2 Arabidopsis thaliana 32-36 9733523-3 1998 phyA was the major photoreceptor/effector for most far-red-light responses, although phyB and cry1 modulated anthocyanin accumulation in a phyA-dependent manner. Anthocyanins 109-120 phytochrome B Arabidopsis thaliana 85-89 9733523-3 1998 phyA was the major photoreceptor/effector for most far-red-light responses, although phyB and cry1 modulated anthocyanin accumulation in a phyA-dependent manner. Anthocyanins 109-120 cryptochrome 1 Arabidopsis thaliana 94-98 9668133-3 1998 The Bronze2 (Bz2) gene encodes a type III GST and performs the last genetically defined step of the maize anthocyanin pigment pathway. Anthocyanins 106-117 glutathione S-transferase Zea mays 4-11 9668133-3 1998 The Bronze2 (Bz2) gene encodes a type III GST and performs the last genetically defined step of the maize anthocyanin pigment pathway. Anthocyanins 106-117 glutathione S-transferase Zea mays 13-16 9668133-8 1998 Bz2 and An9 have evolved independently from distinct types of GSTs, but each is regulated by the conserved transcriptional activators of the anthocyanin pathway. Anthocyanins 141-152 glutathione S-transferase Zea mays 0-3 9668129-6 1998 Decreasing CIP7 expression by introducing antisense CIP7 RNA resulted in defects in light-dependent anthocyanin and chlorophyll accumulation. Anthocyanins 100-111 COP1-interacting protein 7 Arabidopsis thaliana 11-15 9668129-6 1998 Decreasing CIP7 expression by introducing antisense CIP7 RNA resulted in defects in light-dependent anthocyanin and chlorophyll accumulation. Anthocyanins 100-111 COP1-interacting protein 7 Arabidopsis thaliana 52-56 9535914-0 1998 Cloning and characterization of Vitis vinifera UDP-glucose:flavonoid 3-O-glucosyltransferase, a homologue of the enzyme encoded by the maize Bronze-1 locus that may primarily serve to glucosylate anthocyanidins in vivo. Anthocyanins 196-210 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 47-92 9535914-0 1998 Cloning and characterization of Vitis vinifera UDP-glucose:flavonoid 3-O-glucosyltransferase, a homologue of the enzyme encoded by the maize Bronze-1 locus that may primarily serve to glucosylate anthocyanidins in vivo. Anthocyanins 196-210 anthocyanidin 3-O-glucosyltransferase Zea mays 141-149 9535914-1 1998 We report here the cloning and optimized expression at 16 degrees C and the characterization of a Vitis vinifera UDP-glucose:flavonoid 3-O-glucosyltransferase, an enzyme responsible for a late step in grapevine anthocyanin biosynthesis. Anthocyanins 211-222 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 113-158 9717435-1 1998 Three new dominant suppressor mutations of the C1 transcription regulator gene in maize--C1-I delta 1, C1-I delta 2 and C1-I delta 3--are described that suppress anthocyanin colouration in kernels similar to the function of the C1-I standard inhibitor. Anthocyanins 162-173 anthocyanin regulatory C1 protein Zea mays 89-93 9717435-1 1998 Three new dominant suppressor mutations of the C1 transcription regulator gene in maize--C1-I delta 1, C1-I delta 2 and C1-I delta 3--are described that suppress anthocyanin colouration in kernels similar to the function of the C1-I standard inhibitor. Anthocyanins 162-173 anthocyanin regulatory C1 protein Zea mays 103-107 9717435-1 1998 Three new dominant suppressor mutations of the C1 transcription regulator gene in maize--C1-I delta 1, C1-I delta 2 and C1-I delta 3--are described that suppress anthocyanin colouration in kernels similar to the function of the C1-I standard inhibitor. Anthocyanins 162-173 anthocyanin regulatory C1 protein Zea mays 103-107 9717435-1 1998 Three new dominant suppressor mutations of the C1 transcription regulator gene in maize--C1-I delta 1, C1-I delta 2 and C1-I delta 3--are described that suppress anthocyanin colouration in kernels similar to the function of the C1-I standard inhibitor. Anthocyanins 162-173 anthocyanin regulatory C1 protein Zea mays 103-107 9490743-5 1998 Hybrid receptor proteins mediate functions similar to cry1 and include inhibition of hypocotyl elongation and blue light-dependent anthocyanin accumulation; differences in activity appear to be correlated with differing protein stability. Anthocyanins 131-142 cryptochrome 1 Arabidopsis thaliana 54-58 9680994-1 1998 The regulatory anthocyanin loci, an1, an2, an4 and an11 of Petunia hybrida, and r and c1 from Zea mays, control transcription of different sets of target genes. Anthocyanins 15-26 ent-copalyl diphosphate synthase 2, chloroplastic Zea mays 38-41 9177323-6 1997 Rap-1 does not correspond to one of the known loci involved in anthocyanin biosynthesis, since it is located at a different map position. Anthocyanins 63-74 Retinoblastoma-related protein 1 Zea mays 0-5 9393451-1 1997 The duplicated R and Sn genes are involved in the regulation of the maize anthocyanin biosynthetic pathway, encoding tissue-specific products that are homologous to the helix-loop-helix transcriptional activators. Anthocyanins 74-85 CAP-GLY domain containing linker protein 1 Rattus norvegicus 21-23 9286105-4 1997 Our data indicate that ABI3 interacts genetically with both FUS3 and LEC1 in controlling each of the elementary processes analyzed, namely, accumulation of chlorophyll and anthocyanins, sensitivity to abscisic acid, and expression of individual members of the 12S storage protein gene family. Anthocyanins 172-184 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 23-27 9286105-4 1997 Our data indicate that ABI3 interacts genetically with both FUS3 and LEC1 in controlling each of the elementary processes analyzed, namely, accumulation of chlorophyll and anthocyanins, sensitivity to abscisic acid, and expression of individual members of the 12S storage protein gene family. Anthocyanins 172-184 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 60-64 9286105-4 1997 Our data indicate that ABI3 interacts genetically with both FUS3 and LEC1 in controlling each of the elementary processes analyzed, namely, accumulation of chlorophyll and anthocyanins, sensitivity to abscisic acid, and expression of individual members of the 12S storage protein gene family. Anthocyanins 172-184 Histone superfamily protein Arabidopsis thaliana 69-73 9223346-4 1997 The sequence of AtMRP1 and the transport capabilities of membranes prepared from yeast cells transformed with plasmid-borne AtMRP1 demonstrate that this gene encodes an ATP-binding cassette transporter competent in the transport of glutathione S-conjugates of xenobiotics and endogenous substances, including herbicides and anthocyanins. Anthocyanins 324-336 multidrug resistance-associated protein 1 Arabidopsis thaliana 16-22 9223346-4 1997 The sequence of AtMRP1 and the transport capabilities of membranes prepared from yeast cells transformed with plasmid-borne AtMRP1 demonstrate that this gene encodes an ATP-binding cassette transporter competent in the transport of glutathione S-conjugates of xenobiotics and endogenous substances, including herbicides and anthocyanins. Anthocyanins 324-336 multidrug resistance-associated protein 1 Arabidopsis thaliana 124-130 9477570-3 1998 spa1 phyA-105 double mutants exhibit restoration of several responses to limiting fluence rates of continuous far-red light that are absent in the parental phyA-105 mutant, such as deetiolation, anthocyanin accumulation, and a far-red light-induced inability of seedlings to green upon subsequent transfer to continuous white light. Anthocyanins 195-206 SPA (suppressor of phyA-105) protein family Arabidopsis thaliana 0-4 9477570-3 1998 spa1 phyA-105 double mutants exhibit restoration of several responses to limiting fluence rates of continuous far-red light that are absent in the parental phyA-105 mutant, such as deetiolation, anthocyanin accumulation, and a far-red light-induced inability of seedlings to green upon subsequent transfer to continuous white light. Anthocyanins 195-206 phytochrome A Arabidopsis thaliana 5-9 12223864-7 1997 These included chalcone synthase and UDP-glucose-flavonoid 3-O-glucosyl transferase, both of which are involved in anthocyanin synthesis, a chitinase, and a ripening-related gene of an unknown function. Anthocyanins 115-126 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 37-83 9192870-1 1997 In petunia flowers, the loci an1, an2, and an11 control the pigmentation of the flower by stimulating the transcription of anthocyanin biosynthetic genes. Anthocyanins 123-134 DDB1 and CUL4 associated factor 7 Homo sapiens 43-47 9192870-4 1997 RNA gel blot experiments show that an11 is expressed independently from an1 and an2 throughout plant development, as well as in tissues that do not express the anthocyanin pathway. Anthocyanins 160-171 DDB1 and CUL4 associated factor 7 Homo sapiens 35-39 9192870-7 1997 Overexpression of an2 in an11- petals restored the activity of a structural anthocyanin gene in transient assays, indicating that AN11 acts upstream of AN2. Anthocyanins 76-87 DDB1 and CUL4 associated factor 7 Homo sapiens 25-29 9192870-7 1997 Overexpression of an2 in an11- petals restored the activity of a structural anthocyanin gene in transient assays, indicating that AN11 acts upstream of AN2. Anthocyanins 76-87 DDB1 and CUL4 associated factor 7 Homo sapiens 130-134 8953250-7 1996 In addition, transgenic plants overexpressing CRY1 showed increased anthocyanin accumulation in response to blue, UV-A, and green light in a fluence rate-dependent manner. Anthocyanins 68-79 cryptochrome 1 Arabidopsis thaliana 46-50 9008391-1 1997 The Bronze2 (Bz2) gene in maize (Zea mays) encodes a glutathione S-transferase that performs the last genetically defined step in anthocyanin biosynthesis--tagging anthocyanin precursors with glutathione, allowing for recognition and entry of anthocyanins into the vacuole. Anthocyanins 130-141 glutathione S-transferase Zea mays 4-11 9008391-1 1997 The Bronze2 (Bz2) gene in maize (Zea mays) encodes a glutathione S-transferase that performs the last genetically defined step in anthocyanin biosynthesis--tagging anthocyanin precursors with glutathione, allowing for recognition and entry of anthocyanins into the vacuole. Anthocyanins 130-141 glutathione S-transferase Zea mays 13-16 9008391-1 1997 The Bronze2 (Bz2) gene in maize (Zea mays) encodes a glutathione S-transferase that performs the last genetically defined step in anthocyanin biosynthesis--tagging anthocyanin precursors with glutathione, allowing for recognition and entry of anthocyanins into the vacuole. Anthocyanins 164-175 glutathione S-transferase Zea mays 4-11 9008391-1 1997 The Bronze2 (Bz2) gene in maize (Zea mays) encodes a glutathione S-transferase that performs the last genetically defined step in anthocyanin biosynthesis--tagging anthocyanin precursors with glutathione, allowing for recognition and entry of anthocyanins into the vacuole. Anthocyanins 164-175 glutathione S-transferase Zea mays 13-16 9008391-1 1997 The Bronze2 (Bz2) gene in maize (Zea mays) encodes a glutathione S-transferase that performs the last genetically defined step in anthocyanin biosynthesis--tagging anthocyanin precursors with glutathione, allowing for recognition and entry of anthocyanins into the vacuole. Anthocyanins 243-255 glutathione S-transferase Zea mays 4-11 9008391-1 1997 The Bronze2 (Bz2) gene in maize (Zea mays) encodes a glutathione S-transferase that performs the last genetically defined step in anthocyanin biosynthesis--tagging anthocyanin precursors with glutathione, allowing for recognition and entry of anthocyanins into the vacuole. Anthocyanins 243-255 glutathione S-transferase Zea mays 13-16 8980509-6 1996 Restriction fragment length polymorphism mapping demonstrated that Atmyc1 is located on the upper region of chromosome 4, which clearly indicates that Atmyc1 is distinct from the ttg (transparent testa glabrous) locus that affects both trichome development and anthocyanin biosynthesis. Anthocyanins 261-272 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 67-73 8980509-6 1996 Restriction fragment length polymorphism mapping demonstrated that Atmyc1 is located on the upper region of chromosome 4, which clearly indicates that Atmyc1 is distinct from the ttg (transparent testa glabrous) locus that affects both trichome development and anthocyanin biosynthesis. Anthocyanins 261-272 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 151-157 9107032-1 1997 Blue-light responses in higher plants are mediated by specific photoreceptors, which are thought to be flavoproteins; one such flavin-type blue-light receptor, CRY1 (for cryptochrome), which mediates inhibition of hypocotyl elongation and anthocyanin biosynthesis, has recently been characterized. Anthocyanins 239-250 cryptochrome 1 Arabidopsis thaliana 160-164 9107032-5 1997 It was concluded that CRY1-mediated inhibition of hypocotyl elongation and anthocyanin production requires active phytochrome for full expression, and that this requirement can be supplied by low levels of either phyA or phyB. Anthocyanins 75-86 cryptochrome 1 Arabidopsis thaliana 22-26 8953250-8 1996 This increase in anthocyanin accumulation in transgenic plants was shown to be concomitant with increased blue light-induction of CHS gene expression. Anthocyanins 17-28 Chalcone and stilbene synthase family protein Arabidopsis thaliana 130-133 8588509-2 1995 The intensity of the CL of the anthocyanins was in the order of nasunin > rubrobrassicin > delphinidin > malvin = cyanidin > malvidin, indicating that glucosylation at C-3 and C-5 of the anthocyanin skeleton enhances the CL of the parent compound. Anthocyanins 31-43 complement C3 Homo sapiens 180-183 8653115-3 1996 cla1-1 plants behave like wild-type in their capacity to etiolate and produce anthocyanins indicating that the light signal transduction pathway seems to be unaffected. Anthocyanins 78-90 Deoxyxylulose-5-phosphate synthase Arabidopsis thaliana 0-4 9109497-4 1996 Plant nuclear protooncogene homologs, such as myb and myc have multiple regulatory functions in metabolic pathways not existing in mammalian cells; they are involved in the complex regulation of anthocyanin (purple pigment) and phlobaphene (red pigment) biosynthesis, lignin production, trichome differentiation, dehydration stress gene expression and seed development. Anthocyanins 195-206 MYB proto-oncogene, transcription factor Homo sapiens 46-49 8588509-2 1995 The intensity of the CL of the anthocyanins was in the order of nasunin > rubrobrassicin > delphinidin > malvin = cyanidin > malvidin, indicating that glucosylation at C-3 and C-5 of the anthocyanin skeleton enhances the CL of the parent compound. Anthocyanins 31-42 complement C3 Homo sapiens 180-183 8588509-2 1995 The intensity of the CL of the anthocyanins was in the order of nasunin > rubrobrassicin > delphinidin > malvin = cyanidin > malvidin, indicating that glucosylation at C-3 and C-5 of the anthocyanin skeleton enhances the CL of the parent compound. Anthocyanins 31-42 complement C5 Homo sapiens 188-191 8528277-5 1995 CRY1 was originally defined as the photoreceptor responsible for blue-light-mediated inhibition of hypocotyl elongation and we now report that anthocyanin accumulation in germinating seedlings is an additional phenotype under the control of this photoreceptor--this is shown to be mediated in part by modulation of mRNA levels of chalcone synthase, one of the anthocyanin biosynthetic enzymes. Anthocyanins 143-154 cryptochrome 1 Arabidopsis thaliana 0-4 8528277-5 1995 CRY1 was originally defined as the photoreceptor responsible for blue-light-mediated inhibition of hypocotyl elongation and we now report that anthocyanin accumulation in germinating seedlings is an additional phenotype under the control of this photoreceptor--this is shown to be mediated in part by modulation of mRNA levels of chalcone synthase, one of the anthocyanin biosynthetic enzymes. Anthocyanins 360-371 cryptochrome 1 Arabidopsis thaliana 0-4 8528278-3 1995 Several of these loci (tt3, tt4, tt5 and ttg) are also required for the accumulation of purple anthocyanins in leaves and stems and one locus (ttg) plays additional roles in trichome and root hair development. Anthocyanins 95-107 dihydroflavonol 4-reductase Arabidopsis thaliana 23-26 8528278-3 1995 Several of these loci (tt3, tt4, tt5 and ttg) are also required for the accumulation of purple anthocyanins in leaves and stems and one locus (ttg) plays additional roles in trichome and root hair development. Anthocyanins 95-107 Chalcone and stilbene synthase family protein Arabidopsis thaliana 28-31 8528278-3 1995 Several of these loci (tt3, tt4, tt5 and ttg) are also required for the accumulation of purple anthocyanins in leaves and stems and one locus (ttg) plays additional roles in trichome and root hair development. Anthocyanins 95-107 Chalcone-flavanone isomerase family protein Arabidopsis thaliana 33-36 8893541-1 1996 Investigations of phytochrome mutants of Arabidopsis suggested that the expression of chalcone synthase (chs) and anthocyanin accumulation is predominantly controlled by phytochrome A. Anthocyanins 114-125 phytochrome A Arabidopsis thaliana 170-183 8776895-3 1996 We have succeeded in cloning the intensifier1 gene by transposon tagging with Suppressor-mutator and found, by sequence analyses, that it shares homology with known transcription factors in the anthocyanin pathway, in particular the r1/b1 multigene family in maize. Anthocyanins 194-205 transcription factor BHLH42 Zea mays 33-45 8776895-3 1996 We have succeeded in cloning the intensifier1 gene by transposon tagging with Suppressor-mutator and found, by sequence analyses, that it shares homology with known transcription factors in the anthocyanin pathway, in particular the r1/b1 multigene family in maize. Anthocyanins 194-205 Retinoblastoma-related protein 1 Zea mays 233-238 8768375-1 1996 The C1 regulatory gene of the maize anthocyanin pathway is regulated by a combination of developmental and environmental signals that include the Viviparous1 (Vp1) gene, abscisic acid (ABA), and light. Anthocyanins 36-47 regulatory protein viviparous-1 Zea mays 146-157 8768375-1 1996 The C1 regulatory gene of the maize anthocyanin pathway is regulated by a combination of developmental and environmental signals that include the Viviparous1 (Vp1) gene, abscisic acid (ABA), and light. Anthocyanins 36-47 regulatory protein viviparous-1 Zea mays 159-162 8676869-4 1996 The fb seedlings produced high anthocyanin levels, developed into small fragile plants, and were insensitive to the herbicide phosphinothricin. Anthocyanins 31-42 alpha-dioxygenase 2 Solanum lycopersicum 4-6 15012285-3 1996 In addition, plant GSTs play a role in the cellular response to auxins and during the normal metabolism of plant secondary products like anthocyanins and cinnamic acid. Anthocyanins 137-149 glutathione S-transferase kappa 1 Homo sapiens 19-23 8722798-3 1996 Combining the Mutator (Mu) suppressible Lg3-Or211 and a1-mum2 alleles in a Mu-active background generated a stock wherein somatic loss of Mu activity resulted in anthocyanin-marked clonal sectors expressing Lg3 in the leaf. Anthocyanins 162-173 liguleless 3 Zea mays 207-210 8588509-2 1995 The intensity of the CL of the anthocyanins was in the order of nasunin > rubrobrassicin > delphinidin > malvin = cyanidin > malvidin, indicating that glucosylation at C-3 and C-5 of the anthocyanin skeleton enhances the CL of the parent compound. Anthocyanins 31-43 complement C5 Homo sapiens 188-191 7939683-1 1994 The Arabidopsis mutant ttg lacks both trichomes (epidermal hairs) and anthocyanin pigments. Anthocyanins 70-81 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 23-26 7760932-3 1995 The protein encoded by the Bronze-2 gene in maize performs the last genetically defined step in anthocyanin biosynthesis, resulting in the deposition of red and purple pigments in the vacuoles of maize tissues. Anthocyanins 96-107 glutathione S-transferase Zea mays 27-35 7599651-6 1995 There is also a CATGCATG sequence, which is known as the Sph box and is shown to be essential for the regulation by VP1 of the maize anthocyanin regulatory gene C1. Anthocyanins 133-144 regulatory protein viviparous-1 Zea mays 116-119 8820861-3 1995 The types of anthocyanins synthesised in plants are controlled by the cytochrome P450 enzymes flavonoid 3"-hydroxylase and flavonoid 3",5"-hydroxylase. Anthocyanins 13-25 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 81-85 8547814-5 1995 Anthocyanin formation and the expression of several flavonoid biosynthesis genes is stimulated by blue light in the wild type but to a much lower extent in hy4. Anthocyanins 0-11 cryptochrome 1 Arabidopsis thaliana 156-159 7813791-4 1994 This normal positional relationship was absent in ttg (transparent testa glabrous) mutants (lacking trichomes, anthocyanins, and seed coat mucilage); epidermal cells in all positions differentiate into root-hair cells. Anthocyanins 111-123 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 50-53 7773305-1 1995 Flavanone 3-hydroxylase (F3H) activity is necessary for the production of both flavonols and anthocyanins. Anthocyanins 93-105 Flavanone 3-dioxygenase 1 Zea mays 0-23 7773305-1 1995 Flavanone 3-hydroxylase (F3H) activity is necessary for the production of both flavonols and anthocyanins. Anthocyanins 93-105 Flavanone 3-dioxygenase 1 Zea mays 25-28 7773305-7 1995 Slot blot analysis showed that F3H transcript levels in young seedlings are increased by high fluence-rate white light treatment in the presence of the anthocyanin regulatory gene -r. HPLC analysis of extracts from developmentally staged anthers showed that flavonol accumulation begins at the uninucleate microspore stage, continues until maturity, and is not controlled by -r. When the expression pattern of several flavonoid biosynthetic genes was analyzed during microsporogenesis, only F3H transcript accumulation was coordinate with the appearance of flavonols in anthers. Anthocyanins 152-163 Flavanone 3-dioxygenase 1 Zea mays 31-34 7773305-7 1995 Slot blot analysis showed that F3H transcript levels in young seedlings are increased by high fluence-rate white light treatment in the presence of the anthocyanin regulatory gene -r. HPLC analysis of extracts from developmentally staged anthers showed that flavonol accumulation begins at the uninucleate microspore stage, continues until maturity, and is not controlled by -r. When the expression pattern of several flavonoid biosynthetic genes was analyzed during microsporogenesis, only F3H transcript accumulation was coordinate with the appearance of flavonols in anthers. Anthocyanins 152-163 Flavanone 3-dioxygenase 1 Zea mays 491-494 12228452-1 1995 Anthocyanins, which accumulate in leaves and stems in response to low temperature and changes in light intensity, are synthesized through the phenylpropanoid pathway that is controlled by key enzymes that include phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS). Anthocyanins 0-12 Chalcone and stilbene synthase family protein Arabidopsis thaliana 251-268 12228452-1 1995 Anthocyanins, which accumulate in leaves and stems in response to low temperature and changes in light intensity, are synthesized through the phenylpropanoid pathway that is controlled by key enzymes that include phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS). Anthocyanins 0-12 Chalcone and stilbene synthase family protein Arabidopsis thaliana 270-273 12228452-6 1995 Histochemical staining for [beta]-glucuronidase activity showed that the PAL1 promoter is preferentially activated in photosynthetically active cells, paralleling anthocyanin accumulation. Anthocyanins 163-174 PHE ammonia lyase 1 Arabidopsis thaliana 73-77 7766046-9 1995 The phenotype of the cyr1 shoot includes abbreviated development with reduction in cotyledon and leaf expansion, limited leaf production, reduced chlorophyll accumulation, failure to accumulate anthocyanins in response to cytokinins, and the formation of a single infertile flower. Anthocyanins 194-206 VEFS-Box of polycomb protein Arabidopsis thaliana 21-25 7907304-3 1994 In tomato, the DFR sequence appeared to be present as a single gene and mapped to a region on chromosome 2 near two loci affecting anthocyanin pigmentation, are and aw. Anthocyanins 131-142 dihydroflavonol 4-reductase Solanum lycopersicum 15-18 8066134-9 1994 It appears that the dominant I allele results in reduction of CHS mRNA, leading to reduction of CHS activity as the basis for inhibition of anthocyanin and proanthocyanin synthesis in soybean seed coats. Anthocyanins 140-151 chalcone synthase Glycine max 62-65 8066134-9 1994 It appears that the dominant I allele results in reduction of CHS mRNA, leading to reduction of CHS activity as the basis for inhibition of anthocyanin and proanthocyanin synthesis in soybean seed coats. Anthocyanins 140-151 chalcone synthase Glycine max 96-99 12232217-0 1994 Complementation of the Tomato anthocyanin without (aw) Mutant Using the Dihydroflavonol 4-Reductase Gene. Anthocyanins 30-41 uncharacterized protein LOC101264803 Solanum lycopersicum 72-99 12232217-2 1994 Earlier studies had indicated that the DFR gene is present in tomato as a single gene located on chromosome 2 near the locus anthocyanin without (aw). Anthocyanins 125-136 uncharacterized protein LOC101264803 Solanum lycopersicum 39-42 12232217-4 1994 When the genomic DFR clone was introduced by Agrobacterium-mediated transformation into plants bearing the aw mutation, primary transgenic seedlings accumulated anthocyanins that could be observed while the plants were still in tissue culture and which continued to be observed as the plants matured. Anthocyanins 161-173 uncharacterized protein LOC101264803 Solanum lycopersicum 17-20 8156599-3 1994 We now report that cyclic GMP is able to trigger the production of anthocyanins, and that a combination of cyclic GMP with calcium can induce the development of fully mature chloroplasts containing all the photosynthetic machinery. Anthocyanins 67-79 GDP-mannose pyrophosphorylase Solanum lycopersicum 26-29 7827497-6 1994 The -98 to -88 region is more important for B/C1 transactivation and shows a strong homology with the region of the Bz1 anthocyanin structural gene promoter shown to be activated by B/C1 and not by P. We identified a 14-bp consensus sequence that is also present in the promoters of three other genes in the anthocyanin pathway, and we propose a model for how the flavonoid regulatory proteins interact with the promoters of the structural genes. Anthocyanins 120-131 anthocyanidin 3-O-glucosyltransferase Zea mays 116-119 7827497-6 1994 The -98 to -88 region is more important for B/C1 transactivation and shows a strong homology with the region of the Bz1 anthocyanin structural gene promoter shown to be activated by B/C1 and not by P. We identified a 14-bp consensus sequence that is also present in the promoters of three other genes in the anthocyanin pathway, and we propose a model for how the flavonoid regulatory proteins interact with the promoters of the structural genes. Anthocyanins 308-319 anthocyanidin 3-O-glucosyltransferase Zea mays 116-119 7920701-1 1994 Two maize genes, Zm 1 and Zm 38, related to the regulatory anthocyanin gene C1 were analyzed molecularly and used for fusion constructs in transient domain swapping experiments with the C1 wild-type gene. Anthocyanins 59-70 myb2 Zea mays 17-21 24190183-0 1993 Light and developmental regulation of the Anp-controlled anthocyanin phenotype of bean pods. Anthocyanins 57-68 natriuretic peptide A Homo sapiens 42-45 24190183-0 1993 Light and developmental regulation of the Anp-controlled anthocyanin phenotype of bean pods. Anthocyanins 57-68 brain expressed associated with NEDD4 1 Homo sapiens 82-86 1620095-1 1992 The putative maize transcription factor genes R and C1 are required for expression of reporter genes with promoters from the Bz1 and A1 genes, which encode enzymes required for anthocyanin biosynthesis in maize. Anthocyanins 177-188 anthocyanidin 3-O-glucosyltransferase Zea mays 125-128 8425044-12 1993 In summary, some of the anthocyanin mutations affect the quantity of soluble PRP1 polypeptides. Anthocyanins 24-35 repetitive proline-rich cell wall protein 1 Glycine max 77-81 8358035-3 1993 This protein may therefore be involved in the synthesis of anthocyanins in the steps after the action of dihydroflavonol 4-reductase. Anthocyanins 59-71 dihydroflavonol-4-reductase Zea mays 105-132 1329770-3 1992 By comparing the I50 values of flavonoids from different classes possessing an identical hydroxyl configuration, we determined the following order of potency for inhibition of GR: anthocyanidin > dihydroflavonol = chalcone > flavonol > catechin. Anthocyanins 180-193 glutathione-disulfide reductase Homo sapiens 176-178 1620095-4 1992 Electroporation of R and C1 expression plasmids also induces the endogenous genes required for anthocyanin synthesis, resulting in pink protoplasts within 24 h. RNase protection analysis demonstrates that accumulation of mRNA from the endogenous Bz1 and Bz2 genes absolutely requires introduced R and C1. Anthocyanins 95-106 anthocyanidin 3-O-glucosyltransferase Zea mays 246-249 12324600-3 1991 det2 mutations result in dark-grown Arabidopsis thaliana seedlings with many characteristics of light-grown plants, including hypocotyl growth inhibition, cotyledon expansion, primary leaf initiation, anthocyanin accumulation, and derepression of light-regulated gene expression. Anthocyanins 201-212 3-oxo-5-alpha-steroid 4-dehydrogenase family protein Arabidopsis thaliana 0-4 1532784-0 1992 The Viviparous-1 gene and abscisic acid activate the C1 regulatory gene for anthocyanin biosynthesis during seed maturation in maize. Anthocyanins 76-87 regulatory protein viviparous-1 Zea mays 4-16 1532784-1 1992 The Viviparous-1 (Vp1) gene is required for expression of the C1 regulatory gene of the anthocyanin pathway in the developing maize seed. Anthocyanins 88-99 regulatory protein viviparous-1 Zea mays 4-16 1532784-1 1992 The Viviparous-1 (Vp1) gene is required for expression of the C1 regulatory gene of the anthocyanin pathway in the developing maize seed. Anthocyanins 88-99 regulatory protein viviparous-1 Zea mays 18-21 1868212-0 1991 Cloning and nucleotide sequence of a cDNA encoding B-Peru, a regulatory protein of the anthocyanin pathway in maize. Anthocyanins 87-98 anthocyanin regulatory R-S protein-like Zea mays 51-57 2369901-1 1990 The C1, B and R genes regulating the maize anthocyanin biosynthetic pathway encode tissue-specific regulatory proteins with similarities to transcriptional activators. Anthocyanins 43-54 anthocyanin regulatory C1 protein Zea mays 4-15 1995419-2 1991 The putative DNA-binding region of C1 fused to the transcriptional activation domain of GAL4 activated transcription of anthocyanin structural gene promoters in c1 aleurones, c1 Rscm2 embryos, and c1 r embryogenic callus. Anthocyanins 120-131 galactose-responsive transcription factor GAL4 Saccharomyces cerevisiae S288C 88-92 1967051-1 1990 The maize Bronze-2 (Bz2) gene, whose product acts late in the anthocyanin biosynthetic pathway, has been cloned and its transcript has been mapped. Anthocyanins 62-73 glutathione S-transferase Zea mays 10-18 1967051-1 1990 The maize Bronze-2 (Bz2) gene, whose product acts late in the anthocyanin biosynthetic pathway, has been cloned and its transcript has been mapped. Anthocyanins 62-73 glutathione S-transferase Zea mays 20-23 2247447-5 1990 We show that the three red-light-regulated chlorophyll a/b binding protein promoters are inappropriately expressed in the roots of det1 seedlings and the blue-light-controlled anthocyanin biosynthetic gene, chalcone synthase, is expressed ectopically in leaf mesophyll cells. Anthocyanins 176-187 light-mediated development protein 1 / deetiolated1 (DET1) Arabidopsis thaliana 131-135 1980524-2 1990 In order to obtain molecular probes for tomato anthocyanin biosynthesis genes, we isolated two cDNAs which encode chalcone synthase (CHS), one of the key enzymes in anthocyanin biosynthesis, from a tomato hypocotyl cDNA library. Anthocyanins 47-58 chalcone synthase 1 Solanum lycopersicum 114-131 1980524-2 1990 In order to obtain molecular probes for tomato anthocyanin biosynthesis genes, we isolated two cDNAs which encode chalcone synthase (CHS), one of the key enzymes in anthocyanin biosynthesis, from a tomato hypocotyl cDNA library. Anthocyanins 47-58 chalcone synthase 1 Solanum lycopersicum 133-136 1980524-2 1990 In order to obtain molecular probes for tomato anthocyanin biosynthesis genes, we isolated two cDNAs which encode chalcone synthase (CHS), one of the key enzymes in anthocyanin biosynthesis, from a tomato hypocotyl cDNA library. Anthocyanins 165-176 chalcone synthase 1 Solanum lycopersicum 114-131 1980524-2 1990 In order to obtain molecular probes for tomato anthocyanin biosynthesis genes, we isolated two cDNAs which encode chalcone synthase (CHS), one of the key enzymes in anthocyanin biosynthesis, from a tomato hypocotyl cDNA library. Anthocyanins 165-176 chalcone synthase 1 Solanum lycopersicum 133-136 1980524-7 1990 We also assayed the activity of CHS and another enzyme in the anthocyanin pathway, flavone 3-hydroxylase, in hypocotyl extracts of wild-type tomato and a number of anthocyanin-deficient mutants. Anthocyanins 164-175 chalcone synthase 1 Solanum lycopersicum 32-35 2369901-5 1990 Luciferase produced from the Bronze1 anthocyanin structural gene promoter was induced 100-fold when co-introduced with the expressed B-Peru or B-I cDNAs. Anthocyanins 37-48 anthocyanidin 3-O-glucosyltransferase Zea mays 29-36 33233708-4 2020 First, the primary mode of intestinal absorption of anthocyanins is through both sGLT1 and GLUT2 glucose transporters. Anthocyanins 52-64 solute carrier family 2 member 2 Homo sapiens 91-96 33808270-7 2021 Anthocyanins degradation followed first-order reaction kinetics (C3G half-life at 25 C = 21.7 days) and was associated with color changes during storage. Anthocyanins 0-12 Rap guanine nucleotide exchange factor 1 Homo sapiens 65-68 33803587-0 2021 MYB-Mediated Regulation of Anthocyanin Biosynthesis. Anthocyanins 27-38 MYB proto-oncogene, transcription factor Homo sapiens 0-3 33803587-5 2021 MYB transcription factors (TFs) occupy a dominant position in the regulatory network of anthocyanin biosynthesis. Anthocyanins 88-99 MYB proto-oncogene, transcription factor Homo sapiens 0-3 33803587-7 2021 In this study, the regulation of anthocyanin biosynthetic mechanisms of MYB-TFs are discussed. Anthocyanins 33-44 MYB proto-oncogene, transcription factor Homo sapiens 72-75 33809701-0 2021 Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells. Anthocyanins 21-33 ERH mRNA splicing and mitosis factor Homo sapiens 127-130 33809701-2 2021 Here, we tested whether the high expression of enhancer of the rudimentary homolog (ERH), which serves as a prognostic factor in some cancers, can influence the efficacy of anthocyanins isolated from fruits of Vitis coignetiae Pulliat, Meoru in Korea (AIMs) on human gastric cancer cells. Anthocyanins 173-185 ERH mRNA splicing and mitosis factor Homo sapiens 84-87 33233701-0 2020 Anthocyanins Derived from Vitis coignetiae Pulliat Contributes Anti-Cancer Effects by Suppressing NF-kappaB Pathways in Hep3B Human Hepatocellular Carcinoma Cells and In Vivo. Anthocyanins 0-12 nuclear factor kappa B subunit 1 Homo sapiens 98-107 33233708-4 2020 First, the primary mode of intestinal absorption of anthocyanins is through both sGLT1 and GLUT2 glucose transporters. Anthocyanins 52-64 solute carrier family 5 member 1 Homo sapiens 81-86 33233081-4 2020 Consumption of anthocyanins for >8 weeks and at doses >300 mg/day significantly reduced levels of FBS, 2-h PPG, HbA1c, and HOMA-IR. Anthocyanins 15-27 serglycin Homo sapiens 107-110 33233081-5 2020 Moreover, anthocyanins administration reduced the levels of FBS, 2-h PPG, HbA1c, and HOMA-IR in type 2 diabetic subjects and HOMA-IR in overweight/obese individuals. Anthocyanins 10-22 serglycin Homo sapiens 69-72 33233226-2 2020 In the present study, predominant anthocyanin compounds in free anthocyanin compounds from purple sweet potato (FAC-PSP) were identified and protein in protein-bound anthocyanin compounds from purple sweet potato (p-BAC-PSP) were assayed. Anthocyanins 34-45 persephin Mus musculus 116-119 33233226-2 2020 In the present study, predominant anthocyanin compounds in free anthocyanin compounds from purple sweet potato (FAC-PSP) were identified and protein in protein-bound anthocyanin compounds from purple sweet potato (p-BAC-PSP) were assayed. Anthocyanins 64-75 persephin Mus musculus 116-119 33233226-2 2020 In the present study, predominant anthocyanin compounds in free anthocyanin compounds from purple sweet potato (FAC-PSP) were identified and protein in protein-bound anthocyanin compounds from purple sweet potato (p-BAC-PSP) were assayed. Anthocyanins 64-75 persephin Mus musculus 116-119 23944713-7 2013 Anthocyanin accumulation defect persists in npr1x exo70B1 double mutants with SA signaling compromised, while ectopic HR is suppressed. Anthocyanins 0-11 regulatory protein (NPR1) Arabidopsis thaliana 44-48 23944713-7 2013 Anthocyanin accumulation defect persists in npr1x exo70B1 double mutants with SA signaling compromised, while ectopic HR is suppressed. Anthocyanins 0-11 exocyst subunit exo70 family protein B1 Arabidopsis thaliana 50-57 33233708-5 2020 Stronger binding affinities may allow anthocyanins to be more inhibitive to glucose absorption compared to the reverse, where GLUT2 expression may also be affected. Anthocyanins 38-50 solute carrier family 2 member 2 Homo sapiens 126-131 33233708-6 2020 Genetic or chemical inhibition of sGLT1 or GLUT2 demonstrate their essential function in anthocyanin absorption across the enterocyte, where the former interacts with a greater variety of anthocyanins but the latter is the major transporter for specific anthocyanin-glycosides. Anthocyanins 89-100 solute carrier family 5 member 1 Homo sapiens 34-39 33233708-6 2020 Genetic or chemical inhibition of sGLT1 or GLUT2 demonstrate their essential function in anthocyanin absorption across the enterocyte, where the former interacts with a greater variety of anthocyanins but the latter is the major transporter for specific anthocyanin-glycosides. Anthocyanins 89-100 solute carrier family 2 member 2 Homo sapiens 43-48 33233708-6 2020 Genetic or chemical inhibition of sGLT1 or GLUT2 demonstrate their essential function in anthocyanin absorption across the enterocyte, where the former interacts with a greater variety of anthocyanins but the latter is the major transporter for specific anthocyanin-glycosides. Anthocyanins 188-200 solute carrier family 5 member 1 Homo sapiens 34-39 33233708-6 2020 Genetic or chemical inhibition of sGLT1 or GLUT2 demonstrate their essential function in anthocyanin absorption across the enterocyte, where the former interacts with a greater variety of anthocyanins but the latter is the major transporter for specific anthocyanin-glycosides. Anthocyanins 188-200 solute carrier family 2 member 2 Homo sapiens 43-48 33233708-6 2020 Genetic or chemical inhibition of sGLT1 or GLUT2 demonstrate their essential function in anthocyanin absorption across the enterocyte, where the former interacts with a greater variety of anthocyanins but the latter is the major transporter for specific anthocyanin-glycosides. Anthocyanins 254-276 solute carrier family 5 member 1 Homo sapiens 34-39 33233708-6 2020 Genetic or chemical inhibition of sGLT1 or GLUT2 demonstrate their essential function in anthocyanin absorption across the enterocyte, where the former interacts with a greater variety of anthocyanins but the latter is the major transporter for specific anthocyanin-glycosides. Anthocyanins 254-276 solute carrier family 2 member 2 Homo sapiens 43-48 33233708-7 2020 Once absorbed, anthocyanins positively modulate GLUT4 density and function in both skeletal muscle and adipose tissues via the upregulation of AMPK and restoration of insulin sensitivity. Anthocyanins 15-27 solute carrier family 2 member 4 Homo sapiens 48-53 33233708-7 2020 Once absorbed, anthocyanins positively modulate GLUT4 density and function in both skeletal muscle and adipose tissues via the upregulation of AMPK and restoration of insulin sensitivity. Anthocyanins 15-27 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 143-147 33233708-7 2020 Once absorbed, anthocyanins positively modulate GLUT4 density and function in both skeletal muscle and adipose tissues via the upregulation of AMPK and restoration of insulin sensitivity. Anthocyanins 15-27 insulin Homo sapiens 167-174 34836668-0 2022 Effect of bovine serum albumin on the stability and antioxidant activity of blueberry anthocyanins during processing and in vitro simulated digestion. Anthocyanins 86-98 albumin Homo sapiens 17-30 34600197-4 2022 The results showed that cyanindin-3-O-glucoside (C3G) was the primary anthocyanin in raspberry, and the binding site of acylation was on the glucoside C-6, and the product was cyanidin-3-(6-salicyloyl) glucoside (C3-6(S) G). Anthocyanins 70-81 Rap guanine nucleotide exchange factor 1 Homo sapiens 24-47 34600197-4 2022 The results showed that cyanindin-3-O-glucoside (C3G) was the primary anthocyanin in raspberry, and the binding site of acylation was on the glucoside C-6, and the product was cyanidin-3-(6-salicyloyl) glucoside (C3-6(S) G). Anthocyanins 70-81 Rap guanine nucleotide exchange factor 1 Homo sapiens 49-52 34861463-1 2022 OBJECTIVE: Cyanidin-3-O-glucoside (C3G), a dietary anthocyanin, possesses various biological properties, including alleviating endoplasmic reticulum (ER) stress. Anthocyanins 51-62 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 35-38 34896231-0 2022 R3-MYB transcription factor LcMYBx from Litchi chinensis negatively regulates anthocyanin biosynthesis by ectopic expression in tobacco. Anthocyanins 78-89 myb-related protein 3R-1-like Nicotiana tabacum 3-6 34896231-2 2022 In plants, anthocyanin synthesis is regulated by MYB activators, but the MYB repressors has been recognized recently. Anthocyanins 11-22 myb-related protein 3R-1-like Nicotiana tabacum 49-52 34798465-0 2022 PIF4-PAP1 interaction affects MYB-bHLH-WD40 complex formation and anthocyanin accumulation in Arabidopsis. Anthocyanins 66-77 phytochrome interacting factor 4 Arabidopsis thaliana 0-4 34893211-2 2022 Herein, we present a unique biobased photonics film with multi-stimuli responsive behavior based on cellulose nanocrystals (CNCs), sorbitol (S) and anthocyanin (Anth). Anthocyanins 161-165 DDB1 and CUL4 associated factor 7 Homo sapiens 148-159 34655725-3 2022 In Arabidopsis, AtCPC (AtCAPRICE) is known to play a negative role in anthocyanin accumulation. Anthocyanins 70-81 Homeodomain-like superfamily protein Arabidopsis thaliana 16-21 34655725-3 2022 In Arabidopsis, AtCPC (AtCAPRICE) is known to play a negative role in anthocyanin accumulation. Anthocyanins 70-81 Homeodomain-like superfamily protein Arabidopsis thaliana 23-32 34798465-4 2022 The present study demonstrated that PIF3 and PIF5 can slightly repress anthocyanin accumulation under NaCl, low nitrogen (-N), or 6-BA treatments; in contrast, PIF4 can significantly repress anthocyanin accumulation. Anthocyanins 71-82 phytochrome interacting factor 3 Arabidopsis thaliana 36-40 34798465-4 2022 The present study demonstrated that PIF3 and PIF5 can slightly repress anthocyanin accumulation under NaCl, low nitrogen (-N), or 6-BA treatments; in contrast, PIF4 can significantly repress anthocyanin accumulation. Anthocyanins 71-82 phytochrome interacting factor 3-like 6 Arabidopsis thaliana 45-49 34798465-4 2022 The present study demonstrated that PIF3 and PIF5 can slightly repress anthocyanin accumulation under NaCl, low nitrogen (-N), or 6-BA treatments; in contrast, PIF4 can significantly repress anthocyanin accumulation. Anthocyanins 191-202 phytochrome interacting factor 4 Arabidopsis thaliana 160-164 34798465-7 2022 Yeast three-hybrid analysis showed that PIF4 competes with TRANSPARENT TESTA 8 (TT8) to bind PAP1, thereby interfering with the regulation of the MBW protein complex in anthocyanin synthesis. Anthocyanins 169-180 phytochrome interacting factor 4 Arabidopsis thaliana 40-44 34798465-8 2022 Consistently, the anthocyanin content in pap1-D/35S::PIF4 and 35S::PAP1/35S::PIF4 seedlings was markedly lower than that in pap1-D and 35S::PAP1 under 6-BA, MeJA, -N, and NaCl stresses, implying that overexpression of PIF4 suppresses anthocyanin accumulation in pap1-D and 35S::PAP1. Anthocyanins 18-29 phytochrome interacting factor 4 Arabidopsis thaliana 53-57 34798465-8 2022 Consistently, the anthocyanin content in pap1-D/35S::PIF4 and 35S::PAP1/35S::PIF4 seedlings was markedly lower than that in pap1-D and 35S::PAP1 under 6-BA, MeJA, -N, and NaCl stresses, implying that overexpression of PIF4 suppresses anthocyanin accumulation in pap1-D and 35S::PAP1. Anthocyanins 18-29 phytochrome interacting factor 4 Arabidopsis thaliana 77-81 34798465-8 2022 Consistently, the anthocyanin content in pap1-D/35S::PIF4 and 35S::PAP1/35S::PIF4 seedlings was markedly lower than that in pap1-D and 35S::PAP1 under 6-BA, MeJA, -N, and NaCl stresses, implying that overexpression of PIF4 suppresses anthocyanin accumulation in pap1-D and 35S::PAP1. Anthocyanins 18-29 phytochrome interacting factor 4 Arabidopsis thaliana 218-222 34798465-8 2022 Consistently, the anthocyanin content in pap1-D/35S::PIF4 and 35S::PAP1/35S::PIF4 seedlings was markedly lower than that in pap1-D and 35S::PAP1 under 6-BA, MeJA, -N, and NaCl stresses, implying that overexpression of PIF4 suppresses anthocyanin accumulation in pap1-D and 35S::PAP1. Anthocyanins 234-245 phytochrome interacting factor 4 Arabidopsis thaliana 53-57 34798465-8 2022 Consistently, the anthocyanin content in pap1-D/35S::PIF4 and 35S::PAP1/35S::PIF4 seedlings was markedly lower than that in pap1-D and 35S::PAP1 under 6-BA, MeJA, -N, and NaCl stresses, implying that overexpression of PIF4 suppresses anthocyanin accumulation in pap1-D and 35S::PAP1. Anthocyanins 234-245 phytochrome interacting factor 4 Arabidopsis thaliana 77-81 34798465-8 2022 Consistently, the anthocyanin content in pap1-D/35S::PIF4 and 35S::PAP1/35S::PIF4 seedlings was markedly lower than that in pap1-D and 35S::PAP1 under 6-BA, MeJA, -N, and NaCl stresses, implying that overexpression of PIF4 suppresses anthocyanin accumulation in pap1-D and 35S::PAP1. Anthocyanins 234-245 phytochrome interacting factor 4 Arabidopsis thaliana 218-222 34798465-10 2022 Taken together, PIF4 plays a negative role in modulating anthocyanin biosynthesis in Arabidopsis under different stress environments, and PIF4 interacts with PAP1 to affect the integrity of the MBW complex. Anthocyanins 57-68 phytochrome interacting factor 4 Arabidopsis thaliana 16-20 34798465-10 2022 Taken together, PIF4 plays a negative role in modulating anthocyanin biosynthesis in Arabidopsis under different stress environments, and PIF4 interacts with PAP1 to affect the integrity of the MBW complex. Anthocyanins 57-68 phytochrome interacting factor 4 Arabidopsis thaliana 138-142 34510592-2 2022 Online databases including PubMed/Medline, Scopus, ISI Web of Science, and Cochrane Library were searched up to June 2020 for randomized controlled trials (RCTs) that examined the effect of anthocyanin supplementation on serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) among patients with metabolic disorders. Anthocyanins 190-201 glutamic--pyruvic transaminase Homo sapiens 237-261 34510592-2 2022 Online databases including PubMed/Medline, Scopus, ISI Web of Science, and Cochrane Library were searched up to June 2020 for randomized controlled trials (RCTs) that examined the effect of anthocyanin supplementation on serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) among patients with metabolic disorders. Anthocyanins 190-201 solute carrier family 17 member 5 Homo sapiens 272-298 34510592-2 2022 Online databases including PubMed/Medline, Scopus, ISI Web of Science, and Cochrane Library were searched up to June 2020 for randomized controlled trials (RCTs) that examined the effect of anthocyanin supplementation on serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) among patients with metabolic disorders. Anthocyanins 190-201 solute carrier family 17 member 5 Homo sapiens 300-303 34856476-6 2022 RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA. Anthocyanins 91-103 NFE2 like bZIP transcription factor 2 Homo sapiens 279-283 34856476-6 2022 RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA. Anthocyanins 91-103 AKT serine/threonine kinase 1 Homo sapiens 292-295 34856476-6 2022 RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA. Anthocyanins 91-103 NLR family pyrin domain containing 3 Homo sapiens 319-324 34856476-6 2022 RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA. Anthocyanins 91-103 tumor necrosis factor Homo sapiens 326-335 34942029-4 2022 ECAP, JAZ6/8, and TPR2 are known to form a transcriptional repressor complex, negatively regulate jasmonate (JA)-responsive anthocyanin accumulation. Anthocyanins 124-135 jasmonate-zim-domain protein 6 Arabidopsis thaliana 6-12 34942029-4 2022 ECAP, JAZ6/8, and TPR2 are known to form a transcriptional repressor complex, negatively regulate jasmonate (JA)-responsive anthocyanin accumulation. Anthocyanins 124-135 Tetratricopeptide repeat (TPR)-like superfamily protein Arabidopsis thaliana 18-22 34942029-7 2022 Further analysis revealed that ECAP interacts with MYB75 (a transcription factor activating anthocyanin biosynthetic genes) and represses its transcriptional activity in the absence of high salinity. Anthocyanins 92-103 production of anthocyanin pigment 1 Arabidopsis thaliana 51-56 34730670-3 2021 There was an increase in the content of dietary fiber, anthocyanins and antioxidant activity with GBF addition, but no changes occurred in the soluble solids, total phenolic compounds, and ascorbic acid content. Anthocyanins 55-67 Kruppel like factor 6 Homo sapiens 98-101 34977111-6 2021 Purified anthocyanins also markedly decreased circulating tumor necrosis factor alpha (WMD: -1.62 pg/mL, 95% CI: -2.76, -0.48 pg/mL; p = 0.005) and C-reactive protein (WMD: -0.028 mg/dL, 95% CI: -0.050, -0.005 mg/dL; p = 0.014). Anthocyanins 9-21 tumor necrosis factor Homo sapiens 58-85 34977111-6 2021 Purified anthocyanins also markedly decreased circulating tumor necrosis factor alpha (WMD: -1.62 pg/mL, 95% CI: -2.76, -0.48 pg/mL; p = 0.005) and C-reactive protein (WMD: -0.028 mg/dL, 95% CI: -0.050, -0.005 mg/dL; p = 0.014). Anthocyanins 9-21 C-reactive protein Homo sapiens 148-166 34977111-7 2021 Besides, administration of anthocyanin-rich berries could significantly lower blood total cholesterol (WMD: -4.48 mg/dL, 95% CI: -8.94, -0.02 mg/dL; p = 0.049) and C-reactive protein (WMD: -0.046 mg/dL, 95% CI: -0.070, -0.022 mg/dL; p < 0.001). Anthocyanins 27-38 C-reactive protein Homo sapiens 164-182 34857851-6 2021 We did a proof of principle of LEDitSHAKE using the system to optimize anthocyanin production in grapevine cell suspension cultures. Anthocyanins 71-82 small integral membrane protein 10 like 2A Homo sapiens 31-41 34281481-4 2021 Delphinidin-3-sambubioside (Dp3-Sam) is an anthocyanin, was extracted from Hibiscus sabdariffa L. The present research aimed to investigate the role of Dp3-Sam in the prevention of hyperlipidemia in vivo and in vitro. Anthocyanins 43-54 APC regulator of WNT signaling pathway Homo sapiens 28-31 34794538-4 2021 Transient activation assays showed that StWRKY13 could enhance the role of StAN2 in promoting anthocyanin biosynthesis in tobacco (Nicotiana tabacum L.). Anthocyanins 94-105 AN2 Solanum tuberosum 75-80 34794538-7 2021 Our findings showed that StWRKY13 could promote anthocyanin biosynthesis by activating StCHS, StF3H, StDFR, and StANS transcription in potato tubers, thereby supporting the theoretical basis for anthocyanins formation in coloured potato tubers. Anthocyanins 48-59 chalcone synthase 1A Solanum tuberosum 87-92 34794538-7 2021 Our findings showed that StWRKY13 could promote anthocyanin biosynthesis by activating StCHS, StF3H, StDFR, and StANS transcription in potato tubers, thereby supporting the theoretical basis for anthocyanins formation in coloured potato tubers. Anthocyanins 48-59 dihydroflavonol-4-reductase Solanum tuberosum 101-106 34794538-7 2021 Our findings showed that StWRKY13 could promote anthocyanin biosynthesis by activating StCHS, StF3H, StDFR, and StANS transcription in potato tubers, thereby supporting the theoretical basis for anthocyanins formation in coloured potato tubers. Anthocyanins 48-59 anthocyanidin synthase Solanum tuberosum 112-117 34632666-0 2021 Light- and pH-regulated Water-soluble Pseudorotaxanes Comprising a Cucurbit(7)uril and a Flavylium-based Axle. Anthocyanins 89-98 phenylalanine hydroxylase Homo sapiens 11-13 34793267-6 2021 We review the BR and light signaling pathways and highlight the important transcription factors that are associated with the synthesis of anthocyanins, such as BZR1 (brassinazole-resistant 1, BR signaling pathway), HY5 (elongated hypocotyl 5) and COP1 (constitutively photomorphogenic 1, light signal transduction pathway), which bind with the target genes involved in anthocyanin synthesis. Anthocyanins 138-150 COP1 E3 ubiquitin ligase Homo sapiens 247-251 34793267-6 2021 We review the BR and light signaling pathways and highlight the important transcription factors that are associated with the synthesis of anthocyanins, such as BZR1 (brassinazole-resistant 1, BR signaling pathway), HY5 (elongated hypocotyl 5) and COP1 (constitutively photomorphogenic 1, light signal transduction pathway), which bind with the target genes involved in anthocyanin synthesis. Anthocyanins 138-150 COP1 E3 ubiquitin ligase Homo sapiens 253-286 34793267-6 2021 We review the BR and light signaling pathways and highlight the important transcription factors that are associated with the synthesis of anthocyanins, such as BZR1 (brassinazole-resistant 1, BR signaling pathway), HY5 (elongated hypocotyl 5) and COP1 (constitutively photomorphogenic 1, light signal transduction pathway), which bind with the target genes involved in anthocyanin synthesis. Anthocyanins 369-380 COP1 E3 ubiquitin ligase Homo sapiens 247-251 34793267-6 2021 We review the BR and light signaling pathways and highlight the important transcription factors that are associated with the synthesis of anthocyanins, such as BZR1 (brassinazole-resistant 1, BR signaling pathway), HY5 (elongated hypocotyl 5) and COP1 (constitutively photomorphogenic 1, light signal transduction pathway), which bind with the target genes involved in anthocyanin synthesis. Anthocyanins 369-380 COP1 E3 ubiquitin ligase Homo sapiens 253-286 34868247-7 2021 The comparative expression analysis of these ABGs indicated that the upregulation of TT8 together with its target genes (such as DFR, ANS, UFGT, and TT19) might promote the anthocyanin accumulation in PL at the early developmental stage (41-91 days). Anthocyanins 173-184 dihydroflavonol-4-reductase Brassica napus 129-132 34730960-0 2021 Dietary Antioxidant Anthocyanins Mitigate Type II Diabetes through Improving the Disorder of Glycometabolism and Insulin Resistance. Anthocyanins 20-32 insulin Homo sapiens 113-120 34735147-0 2021 Lingonberry Anthocyanins Inhibit Hepatic Stellate Cell Activation and Liver Fibrosis via TGFbeta/Smad/ERK Signaling Pathway. Anthocyanins 12-24 Eph receptor B1 Rattus norvegicus 102-105 34091173-1 2021 To enhance the stability of anthocyanin, an amphiphilic peptide C6 with tryptophan amino acid was used to co-assemble with anthocyanin C3G. Anthocyanins 28-39 Rap guanine nucleotide exchange factor 1 Homo sapiens 135-138 34713882-3 2021 In the present study, cyanidin-3-O-glucoside (C3G), a typical anthocyanin with various widely accepted health benefits, was applied to alleviate oxidative stress in pancreas islets under the conditions of hyperglycemia. Anthocyanins 62-73 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 46-49 34868172-5 2021 The identified differentially expressed genes included MdBBX21, which is homologous to Arabidopsis BBX21, suggesting it may be involved in light-induced anthocyanin biosynthesis. Anthocyanins 153-164 salt tolerance homolog2 Arabidopsis thaliana 99-104 34477986-3 2021 The isolation and characterization of functional dihydroflavonol 4-reductase (DFR) and anthocyanidin synthase (ANS) from Caryophyllales plants has indicated a lack of anthocyanins due to suppression of DFR and ANS. Anthocyanins 167-179 dihydroflavonol 4-reductase Arabidopsis thaliana 49-76 34523169-0 2021 Anthocyanin oligomers stimulate browning in 3T3-L1 white adipocytes via activation of the beta3-adrenergic receptor and ERK signaling pathway. Anthocyanins 0-11 adrenoceptor beta 3 Homo sapiens 90-115 34523169-0 2021 Anthocyanin oligomers stimulate browning in 3T3-L1 white adipocytes via activation of the beta3-adrenergic receptor and ERK signaling pathway. Anthocyanins 0-11 mitogen-activated protein kinase 1 Homo sapiens 120-123 34704297-3 2021 In addition, treatment of serum starvation of hFOB osteoblasts with anthocyanins and resveratrol at 1.0 mug/ml reduced apoptosis, the Bax/Bcl-2 ratio, p53, and HDAC1 expression, but increased SIRT1/3 and PGC1alpha mRNA expression, suggesting mitochondrial and epigenetic regulation. Anthocyanins 68-80 apoptosis regulator Bcl-2 Oryzias latipes 138-143 34704297-3 2021 In addition, treatment of serum starvation of hFOB osteoblasts with anthocyanins and resveratrol at 1.0 mug/ml reduced apoptosis, the Bax/Bcl-2 ratio, p53, and HDAC1 expression, but increased SIRT1/3 and PGC1alpha mRNA expression, suggesting mitochondrial and epigenetic regulation. Anthocyanins 68-80 cellular tumor antigen p53 Oryzias latipes 151-154 34704297-3 2021 In addition, treatment of serum starvation of hFOB osteoblasts with anthocyanins and resveratrol at 1.0 mug/ml reduced apoptosis, the Bax/Bcl-2 ratio, p53, and HDAC1 expression, but increased SIRT1/3 and PGC1alpha mRNA expression, suggesting mitochondrial and epigenetic regulation. Anthocyanins 68-80 histone deacetylase 1 Oryzias latipes 160-165 34704297-3 2021 In addition, treatment of serum starvation of hFOB osteoblasts with anthocyanins and resveratrol at 1.0 mug/ml reduced apoptosis, the Bax/Bcl-2 ratio, p53, and HDAC1 expression, but increased SIRT1/3 and PGC1alpha mRNA expression, suggesting mitochondrial and epigenetic regulation. Anthocyanins 68-80 NAD-dependent protein deacetylase sirtuin-1 Oryzias latipes 192-199 34922061-0 2021 Upregulated NLRP3 inflammasome activation is attenuated by anthocyanins in patients with nonalcoholic fatty liver disease: A case-control and an intervention study. Anthocyanins 59-71 NLR family pyrin domain containing 3 Homo sapiens 12-17 34922061-9 2021 After anthocyanin administration, both mRNA expression of NLRP3 inflammasome components (caspase-1, IL-1beta, and IL-18) in PBMCs and plasma levels of IL-1beta and IL-18 decreased dramatically in NAFLD patients compared with controls. Anthocyanins 6-17 NLR family pyrin domain containing 3 Homo sapiens 58-63 34922061-9 2021 After anthocyanin administration, both mRNA expression of NLRP3 inflammasome components (caspase-1, IL-1beta, and IL-18) in PBMCs and plasma levels of IL-1beta and IL-18 decreased dramatically in NAFLD patients compared with controls. Anthocyanins 6-17 caspase 1 Homo sapiens 89-98 34922061-9 2021 After anthocyanin administration, both mRNA expression of NLRP3 inflammasome components (caspase-1, IL-1beta, and IL-18) in PBMCs and plasma levels of IL-1beta and IL-18 decreased dramatically in NAFLD patients compared with controls. Anthocyanins 6-17 interleukin 1 alpha Homo sapiens 100-108 34922061-9 2021 After anthocyanin administration, both mRNA expression of NLRP3 inflammasome components (caspase-1, IL-1beta, and IL-18) in PBMCs and plasma levels of IL-1beta and IL-18 decreased dramatically in NAFLD patients compared with controls. Anthocyanins 6-17 interleukin 18 Homo sapiens 114-119 34922061-9 2021 After anthocyanin administration, both mRNA expression of NLRP3 inflammasome components (caspase-1, IL-1beta, and IL-18) in PBMCs and plasma levels of IL-1beta and IL-18 decreased dramatically in NAFLD patients compared with controls. Anthocyanins 6-17 interleukin 1 alpha Homo sapiens 151-159 34922061-9 2021 After anthocyanin administration, both mRNA expression of NLRP3 inflammasome components (caspase-1, IL-1beta, and IL-18) in PBMCs and plasma levels of IL-1beta and IL-18 decreased dramatically in NAFLD patients compared with controls. Anthocyanins 6-17 interleukin 18 Homo sapiens 164-169 34922061-10 2021 CONCLUSIONS: This study has demonstrated that the activation of NLRP3 inflammasome is highly increased in NAFLD patients, but it can be markedly suppressed by anthocyanins, which provides a rationale for the development of anti-inflammatory therapies in NAFLD. Anthocyanins 159-171 NLR family pyrin domain containing 3 Homo sapiens 64-69 34944868-0 2021 Anthocyanidins Inhibit Growth and Chemosensitize Triple-Negative Breast Cancer via the NF-kappaB Signaling Pathway. Anthocyanins 0-14 nuclear factor kappa B subunit 1 Homo sapiens 87-96 34944868-5 2021 In this study, we show that bilberry-derived anthocyanidins (Anthos) can inhibit the growth and metastasis of TNBC and chemosensitize paclitaxel (PAC)-resistant TNBC cells by modulating the NF-kappaB signaling pathway, as well as metastatic and angiogenic mediators. Anthocyanins 45-59 nuclear factor kappa B subunit 1 Homo sapiens 190-199 34944868-5 2021 In this study, we show that bilberry-derived anthocyanidins (Anthos) can inhibit the growth and metastasis of TNBC and chemosensitize paclitaxel (PAC)-resistant TNBC cells by modulating the NF-kappaB signaling pathway, as well as metastatic and angiogenic mediators. Anthocyanins 61-67 nuclear factor kappa B subunit 1 Homo sapiens 190-199 34699316-1 2021 Cyanidin-3-O-glucoside (C3G) is a kind of anthocyanin which shows strong anti-inflammation, anti-tumor and anti-oxidant properties. Anthocyanins 42-53 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 24-27 34776632-0 2021 Black carrot anthocyanins exhibit neuroprotective effects against MPP+ induced cell death and cytotoxicity via inhibition of oxidative stress mediated apoptosis. Anthocyanins 13-25 M-phase phosphoprotein 6 Homo sapiens 66-69 34418106-3 2021 In this study, we found a WRKY family gene, Pyrus bretschneideri WRKY75, that may be involved in anthocyanin synthesis in pear. Anthocyanins 97-108 WRKY DNA-binding protein 75 Arabidopsis thaliana 65-71 34829542-1 2021 Cyanidin-3-O-glucoside (C3G) is a widespread anthocyanin derivative, which has been reported in vitro to exert potent antioxidant, antiglycation and alpha-glucosidase inhibition effects. Anthocyanins 45-56 Rap guanine nucleotide exchange factor 1 Homo sapiens 24-27 34829542-1 2021 Cyanidin-3-O-glucoside (C3G) is a widespread anthocyanin derivative, which has been reported in vitro to exert potent antioxidant, antiglycation and alpha-glucosidase inhibition effects. Anthocyanins 45-56 sucrase-isomaltase Homo sapiens 149-166 34768843-4 2021 NUC overexpression increased resistance to nitrogen (N) deficiency stress by increasing the chlorophyll content, suppressing anthocyanin accumulation, and increasing the biomass under N deficiency. Anthocyanins 125-136 C2H2-like zinc finger protein Arabidopsis thaliana 0-3 34668550-3 2022 Although these classes of specialized metabolites are derived from distinct metabolic pathways, previous studies with a chalcone isomerase 1 (CHI1)-deficient mutant called anthocyanin free (af) showed that flavonoids are required for terpenoid accumulation in tVI-GTs. Anthocyanins 172-183 chalcone--flavonone isomerase Solanum lycopersicum 120-140 34668550-3 2022 Although these classes of specialized metabolites are derived from distinct metabolic pathways, previous studies with a chalcone isomerase 1 (CHI1)-deficient mutant called anthocyanin free (af) showed that flavonoids are required for terpenoid accumulation in tVI-GTs. Anthocyanins 172-183 chalcone--flavonone isomerase Solanum lycopersicum 142-146 34721993-1 2021 Dihydroflavonol 4-reductase (DFR), a key regulatory enzyme, participated in the biosynthesis of anthocyanins, proanthocyanidins and other flavonoids that essential for plant survival and human health. Anthocyanins 96-108 dihydroflavonol 4-reductase Arabidopsis thaliana 29-32 34721993-7 2021 Subsequently, all three clones were functionally expressed in Escherichia coli, but confirming that only OjDFR1 encode active DFR proteins that catalyzed the reduction of dihydroflavonols to leucoanthocyanidin. Anthocyanins 191-209 dihydroflavonol 4-reductase Arabidopsis thaliana 126-129 34721993-8 2021 Consistant with the biochemical assay results, overexpressing OjDFR1 in Arabidopsis tt3-1 mutant successfully restored the deficiency of anthocyanin and proanthocyanidin, hinting its function as DFR in planta. Anthocyanins 137-148 dihydroflavonol 4-reductase Arabidopsis thaliana 195-198 34685779-4 2021 The transcription of UFGT and ACO2, which encode the key enzymes in anthocyanin and ethylene biosynthesis, respectively, was upregulated in grape cultured cells exposed to sound stimulation. Anthocyanins 68-79 aconitase 2 Homo sapiens 30-34 34681733-6 2021 Moreover, the anti-inflammatory mechanism of anthocyanins is elaborated from the aspects of NF-kappaB, toll like receptor, MAPKs, NO, and ROS and the main efficacy of anthocyanins in inflammation and related diseases is determined. Anthocyanins 45-57 nuclear factor kappa B subunit 1 Homo sapiens 92-101 34805653-7 2021 They are based on direct pH jumps (addition of a base to the flavylium cation) and reverse pH jumps (addition of an acid to equilibrated solutions at higher pH values). Anthocyanins 61-70 phenylalanine hydroxylase Homo sapiens 25-27 34681684-7 2021 The combination of anthocyanins and curcumin resulted in a significant borderline reduction of NF-kappaB immunohistochemistry (IHC) expression in adenoma tissue (geometric mean ratio (GMR): 0.72; 95% confidence interval (CI): 0.51-1.00; p-value: 0.05) and a trend to a reduction of Ki-67 (GMR: 0.73; 95% CI: 0.50-1.08; p-value: 0.11). Anthocyanins 19-31 nuclear factor kappa B subunit 1 Homo sapiens 95-104 34684731-2 2021 Anthocyanins from berries display potent antioxidants and protect against weight gain and insulin resistance in different models of diet-induced metabolic syndrome. Anthocyanins 0-12 insulin Homo sapiens 90-97 34270784-3 2021 Here, we identified an ERF (ethylene response factor) protein, ERF109, involved in light-induced anthocyanin biosynthesis and found that it promotes coloration by directly binding to anthocyanin-related gene promoters. Anthocyanins 97-108 ethylene-responsive transcription factor 2-like Malus domestica 23-26 34270784-3 2021 Here, we identified an ERF (ethylene response factor) protein, ERF109, involved in light-induced anthocyanin biosynthesis and found that it promotes coloration by directly binding to anthocyanin-related gene promoters. Anthocyanins 97-108 ethylene-responsive transcription factor 2-like Malus domestica 28-52 34270784-3 2021 Here, we identified an ERF (ethylene response factor) protein, ERF109, involved in light-induced anthocyanin biosynthesis and found that it promotes coloration by directly binding to anthocyanin-related gene promoters. Anthocyanins 183-194 ethylene-responsive transcription factor 2-like Malus domestica 23-26 34270784-3 2021 Here, we identified an ERF (ethylene response factor) protein, ERF109, involved in light-induced anthocyanin biosynthesis and found that it promotes coloration by directly binding to anthocyanin-related gene promoters. Anthocyanins 183-194 ethylene-responsive transcription factor 2-like Malus domestica 28-52 34633541-3 2021 Functional characterization revealed BoMYB113.1 as positive and BoMYBL2.1 as negative regulators responsible for anthocyanin accumulation. Anthocyanins 113-124 myb-related protein 308 Brassica oleracea 64-73 34633541-9 2021 Additional expression analysis and functional characterization revealed that the positive regulator BoMYB113.1 and negative regulator BoMYBL2.1 may be key genes responsible for anthocyanin accumulation in red cabbage and ornamental kale by upregulating the expression of structural genes. Anthocyanins 177-188 myb-related protein 308 Brassica oleracea 134-143 34091210-8 2021 Annotated transcription factors (TFs), including MYB activators, MYB repressors and bHLHs, that putatively inhibit or enhance the expression of anthocyanin-related genes were identified. Anthocyanins 144-155 MYB proto-oncogene, transcription factor Homo sapiens 49-52 34675946-4 2021 Here, we identified a miPEP encoded in non-mature miR164c putatively targeting grapevine transcription factor VvMYBPA1 (miPEP164c/miPEP-MYBPA1), a positive regulator of key genes in the proanthocyanidin (PA)-biosynthetic pathway, a pathway that competes directly for substrate with the anthocyanin-biosynthetic pathway. Anthocyanins 286-297 mitochondrial intermediate peptidase Homo sapiens 22-27 34224307-4 2021 In this study, we found that the ABA receptor mutants, pyr1pyl1pyl2pyl4 (1124) and pyr1pyl1ply2pyl4pyl5pyl8 (112458) showed less level of chlorophyll and anthocyanin than the wild-type plants, while gain-of-function of RCAR13 transgenic lines inhibited chlorophyll degradation and enhanced anthocyanin accumulation after MeJA treatment. Anthocyanins 154-165 Polyketide cyclase/dehydrase and lipid transport superfamily protein Arabidopsis thaliana 55-59 34224307-4 2021 In this study, we found that the ABA receptor mutants, pyr1pyl1pyl2pyl4 (1124) and pyr1pyl1ply2pyl4pyl5pyl8 (112458) showed less level of chlorophyll and anthocyanin than the wild-type plants, while gain-of-function of RCAR13 transgenic lines inhibited chlorophyll degradation and enhanced anthocyanin accumulation after MeJA treatment. Anthocyanins 290-301 Polyketide cyclase/dehydrase and lipid transport superfamily protein Arabidopsis thaliana 55-59 34224307-4 2021 In this study, we found that the ABA receptor mutants, pyr1pyl1pyl2pyl4 (1124) and pyr1pyl1ply2pyl4pyl5pyl8 (112458) showed less level of chlorophyll and anthocyanin than the wild-type plants, while gain-of-function of RCAR13 transgenic lines inhibited chlorophyll degradation and enhanced anthocyanin accumulation after MeJA treatment. Anthocyanins 290-301 PYR1-like 3 Arabidopsis thaliana 219-225 34224307-6 2021 While transcripts of the enzymes for activation of anthocyanin biosynthesis pathway were analyzed, the results indicating that JA biosynthetic genes, including allene oxide synthase (AOS), LOX3 and LOX4 were enhanced by the link of JAs and ABA receptors. Anthocyanins 51-62 allene oxide synthase Arabidopsis thaliana 160-181 34224307-6 2021 While transcripts of the enzymes for activation of anthocyanin biosynthesis pathway were analyzed, the results indicating that JA biosynthetic genes, including allene oxide synthase (AOS), LOX3 and LOX4 were enhanced by the link of JAs and ABA receptors. Anthocyanins 51-62 allene oxide synthase Arabidopsis thaliana 183-186 34224307-6 2021 While transcripts of the enzymes for activation of anthocyanin biosynthesis pathway were analyzed, the results indicating that JA biosynthetic genes, including allene oxide synthase (AOS), LOX3 and LOX4 were enhanced by the link of JAs and ABA receptors. Anthocyanins 51-62 lipoxygenase 3 Arabidopsis thaliana 189-193 34820310-8 2021 This investigation found that, in the molecular docking simulation, the anthocyanin and ternatin showed producing the negative binding affinity to the ACE2 domain which interacted with RBD glycoprotein SARS-CoV-2. Anthocyanins 72-83 angiotensin converting enzyme 2 Homo sapiens 151-155 34820310-9 2021 Anthocyanin and ternatin were then predicted to be able to influence any inhibitory activity of TNF-alphaR, MMP-9, and IL-6; increase IL-10; and increase HBD2 binding affinity values negatively. Anthocyanins 0-11 matrix metallopeptidase 9 Homo sapiens 108-113 34820310-9 2021 Anthocyanin and ternatin were then predicted to be able to influence any inhibitory activity of TNF-alphaR, MMP-9, and IL-6; increase IL-10; and increase HBD2 binding affinity values negatively. Anthocyanins 0-11 interleukin 6 Homo sapiens 119-123 34820310-9 2021 Anthocyanin and ternatin were then predicted to be able to influence any inhibitory activity of TNF-alphaR, MMP-9, and IL-6; increase IL-10; and increase HBD2 binding affinity values negatively. Anthocyanins 0-11 interleukin 10 Homo sapiens 134-139 34288396-3 2021 Here, we identified that the rop6 mutant exhibited a dramatic tolerant phenotype under Pi-deficient conditions, with higher phosphate accumulation and lower anthocyanin content. Anthocyanins 157-168 RAC-like 3 Arabidopsis thaliana 29-33 34461423-0 2021 Anthocyanin-enriched polyphenols from Hibiscus syriacus L. (Malvaceae) exert anti-osteoporosis effects by inhibiting GSK-3beta and subsequently activating beta-catenin. Anthocyanins 0-11 glycogen synthase kinase 3 alpha b Danio rerio 117-126 34461423-0 2021 Anthocyanin-enriched polyphenols from Hibiscus syriacus L. (Malvaceae) exert anti-osteoporosis effects by inhibiting GSK-3beta and subsequently activating beta-catenin. Anthocyanins 0-11 catenin (cadherin-associated protein), beta 1 Danio rerio 155-167 34416477-0 2021 Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies. Anthocyanins 52-64 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 68-72 34529412-6 2021 Transcriptome analysis revealed that the nine differentially expressed genes related to anthocyanin biosynthesis belonged to the BZ1 group, the homologous enzyme encoded by the maize Bronze-1 locus, which may primarily serve to glucosylate anthocyanidins. Anthocyanins 88-99 anthocyanidin 3-O-glucosyltransferase Zea mays 129-132 34529412-6 2021 Transcriptome analysis revealed that the nine differentially expressed genes related to anthocyanin biosynthesis belonged to the BZ1 group, the homologous enzyme encoded by the maize Bronze-1 locus, which may primarily serve to glucosylate anthocyanidins. Anthocyanins 240-254 anthocyanidin 3-O-glucosyltransferase Zea mays 129-132 34638824-5 2021 Cyanidin-3O-glucoside (Cy3glc), the main constituent of blackberry anthocyanins, diminished TNF-alpha levels at a concentration of 0.02 microg/mL, indicating protective effects as measured with quantitative RT-PCR and multiplex cytokine assays. Anthocyanins 67-79 tumor necrosis factor Homo sapiens 92-101 34556053-1 2021 BACKGROUND: MYB transcription factors, comprising one of the largest transcription factor families in plants, play many roles in secondary metabolism, especially in anthocyanin biosynthesis. Anthocyanins 165-176 MYB proto-oncogene, transcription factor Homo sapiens 12-15 34684313-6 2021 Moreover, the anthocyanidin accelerated the healing of acetic acid-induced ulcer, increased the gene expression of EGF and COX-1, and downregulated MMP-9. Anthocyanins 14-27 epidermal growth factor Mus musculus 115-118 34684313-6 2021 Moreover, the anthocyanidin accelerated the healing of acetic acid-induced ulcer, increased the gene expression of EGF and COX-1, and downregulated MMP-9. Anthocyanins 14-27 cytochrome c oxidase I, mitochondrial Mus musculus 123-128 34684313-6 2021 Moreover, the anthocyanidin accelerated the healing of acetic acid-induced ulcer, increased the gene expression of EGF and COX-1, and downregulated MMP-9. Anthocyanins 14-27 matrix metallopeptidase 9 Mus musculus 148-153 34573067-1 2021 Cyanidin 3-O-glucoside (C3G) is a well-known antioxidant found as a dietary anthocyanin in different fruits and vegetables. Anthocyanins 76-87 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 24-27 34250535-0 2021 Correction: Bilberry anthocyanin improves the serum cholesterol in aging perimenopausal rats via the estrogen receptor signaling pathway. Anthocyanins 21-32 estrogen receptor 1 Rattus norvegicus 101-118 34250535-1 2021 Correction for "Bilberry anthocyanin improves the serum cholesterol in aging perimenopausal rats via the estrogen receptor signaling pathway" by Na Li et al., Food Funct., 2019, 10, 3430-3438, DOI: 10.1039/C9FO00639G. Anthocyanins 25-36 estrogen receptor 1 Rattus norvegicus 105-122 34564416-6 2021 Specifically, we demonstrate that under Pi-limiting conditions, the vip1/vip2 mutants have shorter root hairs and lateral roots, less accumulation of anthocyanin and less accumulation of sulfolipids and galactolipids. Anthocyanins 150-161 VIRE2-interacting protein 1 Arabidopsis thaliana 68-72 34564416-6 2021 Specifically, we demonstrate that under Pi-limiting conditions, the vip1/vip2 mutants have shorter root hairs and lateral roots, less accumulation of anthocyanin and less accumulation of sulfolipids and galactolipids. Anthocyanins 150-161 VIRE2 interacting protein 2 Arabidopsis thaliana 73-77 34091210-8 2021 Annotated transcription factors (TFs), including MYB activators, MYB repressors and bHLHs, that putatively inhibit or enhance the expression of anthocyanin-related genes were identified. Anthocyanins 144-155 MYB proto-oncogene, transcription factor Homo sapiens 65-68 34160854-0 2021 Karrikins control seedling photomorphogenesis and anthocyanin biosynthesis through a HY5-BBX transcriptional module. Anthocyanins 50-61 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 85-88 34160854-6 2021 The bbx20 bbx21 mutant is largely insensitive to treatment with KAR2 , like a hy5 mutant, with regards to inhibition of hypocotyl elongation and anthocyanin accumulation. Anthocyanins 145-156 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 78-81 34160854-7 2021 Detailed analysis of higher order mutants in combination with RNA-seq analysis revealed that anthocyanin accumulation downstream of SMAX1 and SMXL2 is fully dependent on the HY5-BBX module. Anthocyanins 93-104 Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein Arabidopsis thaliana 132-137 34160854-7 2021 Detailed analysis of higher order mutants in combination with RNA-seq analysis revealed that anthocyanin accumulation downstream of SMAX1 and SMXL2 is fully dependent on the HY5-BBX module. Anthocyanins 93-104 Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein Arabidopsis thaliana 142-147 34160854-7 2021 Detailed analysis of higher order mutants in combination with RNA-seq analysis revealed that anthocyanin accumulation downstream of SMAX1 and SMXL2 is fully dependent on the HY5-BBX module. Anthocyanins 93-104 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 174-177 34308490-9 2021 Compared with RsMYB1, the overexpression of RsMYB1-IRs in Arabidopsis pap1 mutant increased anthocyanin accumulation by > sevenfold and upregulated the expression of Arabidopsis flavonoid biosynthesis genes including AtTT8. Anthocyanins 92-103 phosphatidic acid phosphatase 1 Arabidopsis thaliana 70-74 34484410-0 2021 Identification of Stabilization of Malvid Anthocyanins and Antioxidant Stress Activation via the AMPK/SIRT1 Signaling Pathway. Anthocyanins 42-54 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 97-101 34484410-0 2021 Identification of Stabilization of Malvid Anthocyanins and Antioxidant Stress Activation via the AMPK/SIRT1 Signaling Pathway. Anthocyanins 42-54 sirtuin 1 Homo sapiens 102-107 34484410-14 2021 These results indicate that stabilization malvid anthocyanins exerts an antioxidant activity via the AMPK/SIRT1 signaling pathway. Anthocyanins 49-61 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 101-105 34484410-14 2021 These results indicate that stabilization malvid anthocyanins exerts an antioxidant activity via the AMPK/SIRT1 signaling pathway. Anthocyanins 49-61 sirtuin 1 Homo sapiens 106-111 34438266-0 2021 Anthocyanin from purple sweet potato attenuates lead-induced reproductive toxicity mediated by JNK signaling pathway in male mice. Anthocyanins 0-11 mitogen-activated protein kinase 8 Mus musculus 95-98 34423750-6 2021 After adjusting for demographic and lifestyle confounders, each standard deviation (SD)/day higher intake of anthocyanins (SD=44.3 mg/day) was associated with significantly lower cDBP (-1.56 mmHg, 95% CI: -2.65, -0.48) and cMAP (-1.62 mmHg, 95% CI: -2.82, -0.41). Anthocyanins 109-121 cystatin F Homo sapiens 223-227 34087429-6 2021 Anthocyanins appear to impart antioxidant actions via direct antioxidant properties, as well as indirectly via inducing intracellular Nrf2 activation and antioxidant gene expression. Anthocyanins 0-12 NFE2 like bZIP transcription factor 2 Homo sapiens 134-138 34484275-8 2021 The lower level of anthocyanin was associated with lower expression of critical genes involved in anthocyanin biosynthesis, such as flavonoid-3-O-glucosyltransferase (UFGT), myb-related regulatory gene (R2R3-MYB) (MYBA1), basic helix-loop-helix (bHLH) (MYCA1) and the tryptophan-aspartic acid repeat (WDR or WD40) proteins (WDR1). Anthocyanins 19-30 anthocyanidin 3-O-glucosyltransferase UFGT Vitis vinifera 167-171 34484275-8 2021 The lower level of anthocyanin was associated with lower expression of critical genes involved in anthocyanin biosynthesis, such as flavonoid-3-O-glucosyltransferase (UFGT), myb-related regulatory gene (R2R3-MYB) (MYBA1), basic helix-loop-helix (bHLH) (MYCA1) and the tryptophan-aspartic acid repeat (WDR or WD40) proteins (WDR1). Anthocyanins 19-30 myc anthocyanin regulatory protein Vitis vinifera 253-258 34484275-8 2021 The lower level of anthocyanin was associated with lower expression of critical genes involved in anthocyanin biosynthesis, such as flavonoid-3-O-glucosyltransferase (UFGT), myb-related regulatory gene (R2R3-MYB) (MYBA1), basic helix-loop-helix (bHLH) (MYCA1) and the tryptophan-aspartic acid repeat (WDR or WD40) proteins (WDR1). Anthocyanins 19-30 WD-repeat 1 Vitis vinifera 324-328 34351734-0 2021 Disaggregation Behavior of Amyloid beta Fibrils by Anthocyanins Studied by Total-Internal-Reflection-Fluorescence Microscopy Coupled with a Wireless Quartz-Crystal Microbalance Biosensor. Anthocyanins 51-63 amyloid beta precursor protein Homo sapiens 27-39 34351734-5 2021 Here, we succeeded in the direct monitoring of the disaggregation reaction of single amyloid beta (Abeta) fibrils by anthocyanins using total-internal-reflection-fluorescence microscopy with a quartz-crystal microbalance (TIRFM-QCM). Anthocyanins 117-129 amyloid beta precursor protein Homo sapiens 85-97 34351734-5 2021 Here, we succeeded in the direct monitoring of the disaggregation reaction of single amyloid beta (Abeta) fibrils by anthocyanins using total-internal-reflection-fluorescence microscopy with a quartz-crystal microbalance (TIRFM-QCM). Anthocyanins 117-129 amyloid beta precursor protein Homo sapiens 99-104 34351734-6 2021 It is found that the disassembly activity to the Abeta fibrils depends on the number of hydroxyl groups in six-membered ring B of anthocyanin, and only delphinidin-3-galactoside, possessing three hydroxyl groups there, shows high disassembly activity. Anthocyanins 130-141 amyloid beta precursor protein Homo sapiens 49-54 34200683-10 2021 The LR8-treated grapes had higher titratable acidity, while those in the LR4 treatment had higher Brix and extractable anthocyanin and polyphenol content. Anthocyanins 120-131 transmembrane protein 176B Homo sapiens 4-7 34276717-0 2021 Growth Performance Can Be Increased Under High Nitrate and High Salt Stress Through Enhanced Nitrate Reductase Activity in Arabidopsis Anthocyanin Over-Producing Mutant Plants. Anthocyanins 135-146 nitrate reductase 1 Arabidopsis thaliana 93-110 34276717-7 2021 In addition, since anthocyanin functions as a reactive oxygen species (ROS) scavenger under abiotic stress conditions, we investigated whether enhanced anthocyanin content helps Arabidopsis to withstand higher salt stress levels under high NO3 - concentrations by using pap1-D/fls1ko double mutant plants, which accumulate excessive amount of anthocyanin. Anthocyanins 343-354 phosphatidic acid phosphatase 1 Arabidopsis thaliana 270-274 34276717-9 2021 Although both the pap1-D/fls1ko and fls1ko plants accumulated higher anthocyanin levels and radical scavenging activities than Col-0 plants under both normal and salt stress conditions, the fls1ko plants exhibited much better growth than the pap1-D/fls1ko plants. Anthocyanins 69-80 phosphatidic acid phosphatase 1 Arabidopsis thaliana 18-22 34276717-11 2021 Our results demonstrate that optimal levels of anthocyanin accumulation can enhance growth performance of plants under high NO3 - and salt stress conditions. Anthocyanins 47-58 NBL1, DAN family BMP antagonist Homo sapiens 124-127 34193855-4 2021 Here, we showed that SlBBX20 promotes anthocyanin biosynthesis by binding the promoter of the anthocyanin biosynthesis gene SlDFR, suggesting that SlBBX20 directly activates anthocyanin biosynthesis genes. Anthocyanins 38-49 dihydroflavonol 4-reductase Solanum lycopersicum 124-129 34193855-4 2021 Here, we showed that SlBBX20 promotes anthocyanin biosynthesis by binding the promoter of the anthocyanin biosynthesis gene SlDFR, suggesting that SlBBX20 directly activates anthocyanin biosynthesis genes. Anthocyanins 94-105 dihydroflavonol 4-reductase Solanum lycopersicum 124-129 34193855-4 2021 Here, we showed that SlBBX20 promotes anthocyanin biosynthesis by binding the promoter of the anthocyanin biosynthesis gene SlDFR, suggesting that SlBBX20 directly activates anthocyanin biosynthesis genes. Anthocyanins 174-185 dihydroflavonol 4-reductase Solanum lycopersicum 124-129 34193855-6 2021 SlCSN5 gene silencing led to anthocyanin hyperaccumulation in the transgenic tomato calli and shoots, and SlCSN5-2 overexpression decreased anthocyanin accumulation, suggesting thSlCSN5-2 enhanced the ubiquitination of SlBBX20 and promoted the degradation of SlBBX20 in vivo. Anthocyanins 29-40 COP9 signalosome complex subunit CSN5 Solanum lycopersicum 0-6 34201713-3 2021 In this study, we targeted the genes of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, and two transcriptional factors, MYBL2 and ANAC032, negatively regulating anthocyanin biosynthesis in Arabidopsis. Anthocyanins 97-108 Chalcone and stilbene synthase family protein Arabidopsis thaliana 40-57 34201713-3 2021 In this study, we targeted the genes of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, and two transcriptional factors, MYBL2 and ANAC032, negatively regulating anthocyanin biosynthesis in Arabidopsis. Anthocyanins 97-108 Chalcone and stilbene synthase family protein Arabidopsis thaliana 59-62 34201713-3 2021 In this study, we targeted the genes of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, and two transcriptional factors, MYBL2 and ANAC032, negatively regulating anthocyanin biosynthesis in Arabidopsis. Anthocyanins 205-216 MYB-like 2 Arabidopsis thaliana 164-169 34201713-3 2021 In this study, we targeted the genes of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, and two transcriptional factors, MYBL2 and ANAC032, negatively regulating anthocyanin biosynthesis in Arabidopsis. Anthocyanins 205-216 NAC domain containing protein 32 Arabidopsis thaliana 174-181 34201713-4 2021 Direct foliar application of AtCHS-specific dsRNAs and siRNAs resulted in an efficient downregulation of the AtCHS gene and suppressed anthocyanin accumulation in A. thaliana under anthocyanin biosynthesis-modulating conditions. Anthocyanins 135-146 Chalcone and stilbene synthase family protein Arabidopsis thaliana 29-34 34201713-4 2021 Direct foliar application of AtCHS-specific dsRNAs and siRNAs resulted in an efficient downregulation of the AtCHS gene and suppressed anthocyanin accumulation in A. thaliana under anthocyanin biosynthesis-modulating conditions. Anthocyanins 181-192 Chalcone and stilbene synthase family protein Arabidopsis thaliana 29-34 34201713-6 2021 The content of anthocyanins was increased after treatment with AtMYBL2-dsRNA. Anthocyanins 15-27 MYB-like 2 Arabidopsis thaliana 63-70 34392146-8 2021 FINDINGS: Compared to placebo group, anthocyanins at 80 mg/day for 12 weeks reduced collagen-induced platelet aggregation (-3.39+-2.36%) and activated GPIIbIIIa (-8.25+-2.45%) (P < 0.05). Anthocyanins 37-49 integrin alpha 2b Mus musculus 151-160 34333541-6 2021 In flowers, the overexpression of MYB10 in Malus domestica enhanced the accumulation of anthocyanin, but decreased that of kaempferol 3-O-glycosides. Anthocyanins 88-99 transcription factor MYB113-like Malus domestica 34-39 34247029-5 2021 Furthermore, RsGST1 was able to restore anthocyanin accumulation in Arabidopsis tt19 mutants, indicating that RsGST1 has a similar function as AtTT19, a gene responsible for the transport of anthocyanins in Arabidopsis. Anthocyanins 191-203 glutathione S-transferase phi 12 Arabidopsis thaliana 143-149 34439483-6 2021 Separate immunoblot analysis supported these observations, indicating increased activation of extracellular signal-related kinase (ERK1), Akt Ser473, mammalian target of rapamycin (mTOR) Ser2448, activity-regulated cytoskeleton-associated protein (Arc/Arg 3.1) and brain-derived neurotrophic factor (BDNF) in response to anthocyanin treatment, whilst alpha-E-catenin, c-Jun N-terminal kinase (JNK1) and p38 protein levels decreased. Anthocyanins 321-332 mitogen-activated protein kinase 3 Homo sapiens 131-135 34439483-6 2021 Separate immunoblot analysis supported these observations, indicating increased activation of extracellular signal-related kinase (ERK1), Akt Ser473, mammalian target of rapamycin (mTOR) Ser2448, activity-regulated cytoskeleton-associated protein (Arc/Arg 3.1) and brain-derived neurotrophic factor (BDNF) in response to anthocyanin treatment, whilst alpha-E-catenin, c-Jun N-terminal kinase (JNK1) and p38 protein levels decreased. Anthocyanins 321-332 AKT serine/threonine kinase 1 Homo sapiens 138-141 34439483-6 2021 Separate immunoblot analysis supported these observations, indicating increased activation of extracellular signal-related kinase (ERK1), Akt Ser473, mammalian target of rapamycin (mTOR) Ser2448, activity-regulated cytoskeleton-associated protein (Arc/Arg 3.1) and brain-derived neurotrophic factor (BDNF) in response to anthocyanin treatment, whilst alpha-E-catenin, c-Jun N-terminal kinase (JNK1) and p38 protein levels decreased. Anthocyanins 321-332 mechanistic target of rapamycin kinase Homo sapiens 150-179 34439483-6 2021 Separate immunoblot analysis supported these observations, indicating increased activation of extracellular signal-related kinase (ERK1), Akt Ser473, mammalian target of rapamycin (mTOR) Ser2448, activity-regulated cytoskeleton-associated protein (Arc/Arg 3.1) and brain-derived neurotrophic factor (BDNF) in response to anthocyanin treatment, whilst alpha-E-catenin, c-Jun N-terminal kinase (JNK1) and p38 protein levels decreased. Anthocyanins 321-332 mechanistic target of rapamycin kinase Homo sapiens 181-185 34439483-6 2021 Separate immunoblot analysis supported these observations, indicating increased activation of extracellular signal-related kinase (ERK1), Akt Ser473, mammalian target of rapamycin (mTOR) Ser2448, activity-regulated cytoskeleton-associated protein (Arc/Arg 3.1) and brain-derived neurotrophic factor (BDNF) in response to anthocyanin treatment, whilst alpha-E-catenin, c-Jun N-terminal kinase (JNK1) and p38 protein levels decreased. Anthocyanins 321-332 activity regulated cytoskeleton associated protein Homo sapiens 215-259 34439483-6 2021 Separate immunoblot analysis supported these observations, indicating increased activation of extracellular signal-related kinase (ERK1), Akt Ser473, mammalian target of rapamycin (mTOR) Ser2448, activity-regulated cytoskeleton-associated protein (Arc/Arg 3.1) and brain-derived neurotrophic factor (BDNF) in response to anthocyanin treatment, whilst alpha-E-catenin, c-Jun N-terminal kinase (JNK1) and p38 protein levels decreased. Anthocyanins 321-332 brain derived neurotrophic factor Homo sapiens 265-298 34439483-6 2021 Separate immunoblot analysis supported these observations, indicating increased activation of extracellular signal-related kinase (ERK1), Akt Ser473, mammalian target of rapamycin (mTOR) Ser2448, activity-regulated cytoskeleton-associated protein (Arc/Arg 3.1) and brain-derived neurotrophic factor (BDNF) in response to anthocyanin treatment, whilst alpha-E-catenin, c-Jun N-terminal kinase (JNK1) and p38 protein levels decreased. Anthocyanins 321-332 brain derived neurotrophic factor Homo sapiens 300-304 34439483-6 2021 Separate immunoblot analysis supported these observations, indicating increased activation of extracellular signal-related kinase (ERK1), Akt Ser473, mammalian target of rapamycin (mTOR) Ser2448, activity-regulated cytoskeleton-associated protein (Arc/Arg 3.1) and brain-derived neurotrophic factor (BDNF) in response to anthocyanin treatment, whilst alpha-E-catenin, c-Jun N-terminal kinase (JNK1) and p38 protein levels decreased. Anthocyanins 321-332 catenin alpha 1 Homo sapiens 351-366 34439483-6 2021 Separate immunoblot analysis supported these observations, indicating increased activation of extracellular signal-related kinase (ERK1), Akt Ser473, mammalian target of rapamycin (mTOR) Ser2448, activity-regulated cytoskeleton-associated protein (Arc/Arg 3.1) and brain-derived neurotrophic factor (BDNF) in response to anthocyanin treatment, whilst alpha-E-catenin, c-Jun N-terminal kinase (JNK1) and p38 protein levels decreased. Anthocyanins 321-332 mitogen-activated protein kinase 8 Homo sapiens 393-397 34439483-6 2021 Separate immunoblot analysis supported these observations, indicating increased activation of extracellular signal-related kinase (ERK1), Akt Ser473, mammalian target of rapamycin (mTOR) Ser2448, activity-regulated cytoskeleton-associated protein (Arc/Arg 3.1) and brain-derived neurotrophic factor (BDNF) in response to anthocyanin treatment, whilst alpha-E-catenin, c-Jun N-terminal kinase (JNK1) and p38 protein levels decreased. Anthocyanins 321-332 mitogen-activated protein kinase 14 Homo sapiens 403-406 34367217-4 2021 UDP-glucose flavonoid-3-O-glucosyltransferase (UFGT) activity was positively associated with anthocyanin enrichment. Anthocyanins 93-104 anthocyanidin 3-O-glucosyltransferase 2-like Malus domestica 0-45 34367217-4 2021 UDP-glucose flavonoid-3-O-glucosyltransferase (UFGT) activity was positively associated with anthocyanin enrichment. Anthocyanins 93-104 anthocyanidin 3-O-glucosyltransferase 2-like Malus domestica 47-51 34200816-6 2021 We could not confirm the significant effects of each main anthocyanin on glucose metabolism; however, insulin resistance index changed positively and negatively with cyanidin- and delphinidin-based anthocyanins, respectively. Anthocyanins 58-69 insulin Homo sapiens 102-109 34200816-6 2021 We could not confirm the significant effects of each main anthocyanin on glucose metabolism; however, insulin resistance index changed positively and negatively with cyanidin- and delphinidin-based anthocyanins, respectively. Anthocyanins 198-210 insulin Homo sapiens 102-109 34201208-0 2021 The Role of Anthocyanins, Deoxyanthocyanins and Pyranoanthocyanins on the Modulation of Tyrosinase Activity: An In Vitro and In Silico Approach. Anthocyanins 12-24 tyrosinase Homo sapiens 88-98 34201208-3 2021 Numerous phenolic-based structures from natural sources have been pointed out as potential tyrosinase inhibitors, including anthocyanins. Anthocyanins 124-136 tyrosinase Homo sapiens 91-101 34082675-0 2021 Protective effect of Anthocyanins on Radiation-induced Hippocampal Injury through Activation of SIRT3. Anthocyanins 21-33 sirtuin 3 Rattus norvegicus 96-101 34082675-7 2021 RESULTS: Anthocyanins inhibit radiation-induced apoptosis by activating SIRT3. Anthocyanins 9-21 sirtuin 3 Rattus norvegicus 72-77 34082675-8 2021 SIRT3 mRNA increased 24 hours after anthocyanin performed, accompanied by an increase in SIRT3 protein and activity. Anthocyanins 36-47 sirtuin 3 Rattus norvegicus 0-5 34082675-8 2021 SIRT3 mRNA increased 24 hours after anthocyanin performed, accompanied by an increase in SIRT3 protein and activity. Anthocyanins 36-47 sirtuin 3 Rattus norvegicus 89-94 34082675-10 2021 The results showed that anthocyanin protected hippocampal neurons from apoptosis through the activity of SIRT3 after irradiation. Anthocyanins 24-35 sirtuin 3 Rattus norvegicus 105-110 34070757-5 2021 Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness. Anthocyanins 0-12 mitochondrially encoded cytochrome c oxidase I Homo sapiens 202-207 34070757-5 2021 Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness. Anthocyanins 0-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 213-218 34073767-6 2021 The cultivation method strongly influences anthocyanin content in rice plants; water conditions, light quantity and quality, and available nutrients in the soil are important factors, while the low stability of anthocyanins means that they can be dramatically degraded under high-temperature conditions. Anthocyanins 211-223 DDB1 and CUL4 associated factor 7 Homo sapiens 43-54 34262751-1 2021 This systematic review and meta-analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Anthocyanins 77-89 glutamic--pyruvic transaminase Homo sapiens 170-194 34262751-1 2021 This systematic review and meta-analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Anthocyanins 77-89 solute carrier family 17 member 5 Homo sapiens 202-228 34262751-1 2021 This systematic review and meta-analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Anthocyanins 77-89 solute carrier family 17 member 5 Homo sapiens 230-233 34262751-1 2021 This systematic review and meta-analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Anthocyanins 77-89 gamma-glutamyltransferase 1 Homo sapiens 240-266 34262751-1 2021 This systematic review and meta-analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Anthocyanins 77-89 gamma-glutamyltransferase 1 Homo sapiens 268-271 34262751-1 2021 This systematic review and meta-analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Anthocyanins 91-95 glutamic--pyruvic transaminase Homo sapiens 170-194 34262751-1 2021 This systematic review and meta-analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Anthocyanins 91-95 solute carrier family 17 member 5 Homo sapiens 202-228 34262751-1 2021 This systematic review and meta-analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Anthocyanins 91-95 solute carrier family 17 member 5 Homo sapiens 230-233 34262751-1 2021 This systematic review and meta-analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Anthocyanins 91-95 gamma-glutamyltransferase 1 Homo sapiens 240-266 34262751-1 2021 This systematic review and meta-analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Anthocyanins 91-95 gamma-glutamyltransferase 1 Homo sapiens 268-271 34262751-3 2021 A significant decrease was found on AST among the healthy subjects (WMD = -4.325 U/L, 95% CI = -8.516 to -0.134, p = .043) and in the studies that used products containing ACNs as intervention (WMD = -2.201 U/L, 95% CI = -4.275 to -0.127, p = .037). Anthocyanins 172-176 solute carrier family 17 member 5 Homo sapiens 36-39 34262751-4 2021 Although no significant relation was detected between ACNs dosage and the liver enzymes, significant associations were found between the duration of trial with ALT (ALT: slope: 0.09, 95% CI = 0.040 to 0.139, p = .0003) and AST (slope: 0.076, 95% CI = 0.037 to 0.115, p = .0001). Anthocyanins 54-58 solute carrier family 17 member 5 Homo sapiens 223-226 34262751-5 2021 In conclusion, although ACNs had no significant effect on the liver enzymes, a significant decrease was discovered on ALT and AST in the studies that evaluated them as primary outcomes. Anthocyanins 24-28 solute carrier family 17 member 5 Homo sapiens 126-129 34262751-6 2021 A significant reduction was observed in AST in the healthy individuals and in the studies used products containing ACNs as intervention. Anthocyanins 115-119 solute carrier family 17 member 5 Homo sapiens 40-43 34981470-11 2021 It can be concluded that medicinal plants, and herbal bioactive compounds, particularly curcumin, anthocyanins, resveratrol, soy, walnut, and dihydromyricetin can be used as adjunct or complementary therapeutic agents to increase plasma adiponectin, which could potentially prevent and treat NCDs. Anthocyanins 98-110 adiponectin, C1Q and collagen domain containing Homo sapiens 237-248 35631301-6 2022 Anthocyanins exert their beneficial effects through improvements in gut microbiota, oxidative stress and inflammation, and modulation of neuropeptides such as insulin-like growth factor-1. Anthocyanins 0-12 insulin like growth factor 1 Homo sapiens 159-187 35609368-2 2022 Cyanidin-3-O-glucoside (C3G) is the most abundant anthocyanin in haskap berries, and C3G induces antiproliferative pharmacological activity in various cancer cells. Anthocyanins 50-61 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 24-27 35609368-2 2022 Cyanidin-3-O-glucoside (C3G) is the most abundant anthocyanin in haskap berries, and C3G induces antiproliferative pharmacological activity in various cancer cells. Anthocyanins 50-61 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 85-88 35357518-6 2022 The findings of this review confirm that polyphenols, flavonoids, alkaloids, terpenoids, and anthocyanins are capable of modulating FOXO1 and associated signaling pathways, and they are potential therapeutic agents for NAFLD and related complications. Anthocyanins 93-105 forkhead box O1 Homo sapiens 132-137 35182426-0 2022 Nitrogen deficiency- and sucrose-induced anthocyanin biosynthesis is modulated by HISTONE DEACETYLASE15 in Arabidopsis. Anthocyanins 41-52 histone deacetylase 15 Arabidopsis thaliana 82-103 35182426-3 2022 N deficiency-induced anthocyanin accumulation is modulated by HISTONE DEACETYLASE15 (HDA15) in Arabidopsis seedlings. Anthocyanins 21-32 histone deacetylase 15 Arabidopsis thaliana 62-83 35182426-3 2022 N deficiency-induced anthocyanin accumulation is modulated by HISTONE DEACETYLASE15 (HDA15) in Arabidopsis seedlings. Anthocyanins 21-32 histone deacetylase 15 Arabidopsis thaliana 85-90 35182426-7 2022 The accumulation of anthocyanins induced by sucrose and methyl jasmonate, but not that induced by H2O2 and phosphate starvation, was also further enhanced in the hda15-1 mutant. Anthocyanins 20-32 histone deacetylase 15 Arabidopsis thaliana 162-167 35182426-8 2022 While sucrose increases histone acetylation in genes in a similar manner to that caused by N deficiency, methyl jasmonate only enhances histone acetylation in genes involved in anthocyanin biosynthesis in the hda15-1 mutant. Anthocyanins 177-188 histone deacetylase 15 Arabidopsis thaliana 209-214 35182426-9 2022 These results suggest that different stresses act through distinct regulatory modules to activate anthocyanin biosynthesis and that HDA15-mediated histone modification modulates the expression of anthocyanin biosynthetic and regulatory genes to avoid anthocyanin over-accumulation in response to N deficiency and other stresses. Anthocyanins 196-207 histone deacetylase 15 Arabidopsis thaliana 132-137 35630816-0 2022 Functional Characterization of Flavanone 3-Hydroxylase (F3H) and Its Role in Anthocyanin and Flavonoid Biosynthesis in Mulberry. Anthocyanins 77-88 flavanone 3-hydroxylase Nicotiana tabacum 31-54 35630816-0 2022 Functional Characterization of Flavanone 3-Hydroxylase (F3H) and Its Role in Anthocyanin and Flavonoid Biosynthesis in Mulberry. Anthocyanins 77-88 flavanone 3-hydroxylase Nicotiana tabacum 56-59 35630816-3 2022 Flavanone 3-hydroxylase (F3H) catalyzes the conversion of naringenin into dihydroflavonols and is responsible for the biosynthesis of flavonols and anthocyanidins. Anthocyanins 148-162 flavanone 3-hydroxylase Nicotiana tabacum 0-23 35630816-3 2022 Flavanone 3-hydroxylase (F3H) catalyzes the conversion of naringenin into dihydroflavonols and is responsible for the biosynthesis of flavonols and anthocyanidins. Anthocyanins 148-162 flavanone 3-hydroxylase Nicotiana tabacum 25-28 35630816-9 2022 F3H expression levels showed a positive and close relationship with anthocyanin content during the anthocyanin-rich fruit ripening process, while it showed a negative correlation with anthocyanin content in LvShenZi, whose fruits are white and would not experience anthocyanin accumulation during fruit ripening. Anthocyanins 68-79 flavanone 3-hydroxylase Nicotiana tabacum 0-3 35630816-9 2022 F3H expression levels showed a positive and close relationship with anthocyanin content during the anthocyanin-rich fruit ripening process, while it showed a negative correlation with anthocyanin content in LvShenZi, whose fruits are white and would not experience anthocyanin accumulation during fruit ripening. Anthocyanins 99-110 flavanone 3-hydroxylase Nicotiana tabacum 0-3 35630816-9 2022 F3H expression levels showed a positive and close relationship with anthocyanin content during the anthocyanin-rich fruit ripening process, while it showed a negative correlation with anthocyanin content in LvShenZi, whose fruits are white and would not experience anthocyanin accumulation during fruit ripening. Anthocyanins 184-195 flavanone 3-hydroxylase Nicotiana tabacum 0-3 35630816-9 2022 F3H expression levels showed a positive and close relationship with anthocyanin content during the anthocyanin-rich fruit ripening process, while it showed a negative correlation with anthocyanin content in LvShenZi, whose fruits are white and would not experience anthocyanin accumulation during fruit ripening. Anthocyanins 265-276 flavanone 3-hydroxylase Nicotiana tabacum 0-3 35630816-10 2022 Significantly different F3H expression levels were also found in different mulberry varieties that have quite different anthocyanin contents in ripe fruits. Anthocyanins 120-131 flavanone 3-hydroxylase Nicotiana tabacum 24-27 35630816-12 2022 Down-regulation of F3H expression levels resulted in co-expression of the genes involved in anthocyanin biosynthesis and a significant decrease in anthocyanin content, but the change in total flavonoid content was subtle. Anthocyanins 92-103 flavanone 3-hydroxylase Nicotiana tabacum 19-22 35630816-12 2022 Down-regulation of F3H expression levels resulted in co-expression of the genes involved in anthocyanin biosynthesis and a significant decrease in anthocyanin content, but the change in total flavonoid content was subtle. Anthocyanins 147-158 flavanone 3-hydroxylase Nicotiana tabacum 19-22 35552695-9 2022 Mechanistically, SlJAF13 interacts with SlMYC2 and inhibiting SlMYC2 activation of SlJAZ2 transcription, thus constituting a negative feedback loop governing anthocyanin accumulation. Anthocyanins 158-169 transcription factor MYC2 Solanum lycopersicum 40-46 35325659-8 2022 Noticeably, anthocyanin content was significantly reduced in Oe1 and Oe2 compared with the Wt and atl8 under P- condition. Anthocyanins 12-23 RING/U-box superfamily protein Arabidopsis thaliana 98-102 35562569-0 2022 MYB3 plays an important role in lignin and anthocyanin biosynthesis under salt stress condition in Arabidopsis. Anthocyanins 43-54 myb domain protein 3 Arabidopsis thaliana 0-4 35562569-1 2022 KEY MESSAGE: Nuclear-localized Arabidopsis MYB3 functions as a transcriptional repressor for regulation of lignin and anthocyanin biosynthesis under high salt conditions. Anthocyanins 118-129 myb domain protein 3 Arabidopsis thaliana 43-47 35562569-4 2022 Here, to further understand the regulation of plant responses under high salinity conditions, the function of the MYB3 transcription factor was studied as a repressor to control accumulation of lignin and anthocyanin under salt stress conditions. Anthocyanins 205-216 myb domain protein 3 Arabidopsis thaliana 114-118 35562569-12 2022 Overall, these results suggest that nuclear-localized MYB3 functions as a transcriptional repressor to control lignin and anthocyanin accumulation under salinity stress conditions. Anthocyanins 122-133 myb domain protein 3 Arabidopsis thaliana 54-58 35552695-9 2022 Mechanistically, SlJAF13 interacts with SlMYC2 and inhibiting SlMYC2 activation of SlJAZ2 transcription, thus constituting a negative feedback loop governing anthocyanin accumulation. Anthocyanins 158-169 transcription factor MYC2 Solanum lycopersicum 62-68 35628133-5 2022 In this study, we used exogenous gene-specific dsRNA to downregulate the gene of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, in Arabidopsis. Anthocyanins 138-149 Chalcone and stilbene synthase family protein Arabidopsis thaliana 81-98 35628133-5 2022 In this study, we used exogenous gene-specific dsRNA to downregulate the gene of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, in Arabidopsis. Anthocyanins 138-149 Chalcone and stilbene synthase family protein Arabidopsis thaliana 100-103 35634383-5 2022 Colored wheat exists in three forms, purple, blue, and black, depending upon the types and position of the anthocyanins in wheat layers, regulated by the bHLH-MYC transcription factor. Anthocyanins 107-119 MYC proto-oncogene, bHLH transcription factor Homo sapiens 159-162 35615132-0 2022 MdJa2 Participates in the Brassinosteroid Signaling Pathway to Regulate the Synthesis of Anthocyanin and Proanthocyanidin in Red-Fleshed Apple. Anthocyanins 89-100 MADS-box protein JOINTLESS Malus domestica 0-5 35615132-5 2022 Additionally, MdJa2 was responsive to BR signal, and the overexpression of MdJa2 inhibited the synthesis of anthocyanin and proanthocyanidin. Anthocyanins 108-119 MADS-box protein JOINTLESS Malus domestica 14-19 35527510-12 2022 Under light stress, MdBBX22 induced mdm-miR858 expression to inhibit PA accumulation and thereby indirectly enhanced anthocyanin synthesis in the peel. Anthocyanins 117-128 MIR858 Malus domestica 36-46 35615132-5 2022 Additionally, MdJa2 was responsive to BR signal, and the overexpression of MdJa2 inhibited the synthesis of anthocyanin and proanthocyanidin. Anthocyanins 108-119 MADS-box protein JOINTLESS Malus domestica 75-80 35615132-6 2022 The silencing of MdJa2 in "Orin" calli promoted anthocyanin and proanthocyanidin accumulations. Anthocyanins 48-59 MADS-box protein JOINTLESS Malus domestica 17-22 35615132-8 2022 MdJa2 was revealed to independently regulate anthocyanin and proanthocyanidin synthesis pathways. Anthocyanins 45-56 MADS-box protein JOINTLESS Malus domestica 0-5 35508980-0 2022 Anthocyanin regulatory networks in Solanum tuberosum L. leaves elucidated via integrated metabolomics, transcriptomics, and StAN1 overexpression. Anthocyanins 0-11 transcription factor R2R3-MYB Solanum tuberosum 124-129 35513806-7 2022 Poly(adenosine diphosphate (ADP)-ribose) polymerase activity was high, and glutathione S-transferase activity was low in the tumors treated with anthocyanin, methotrexate, or both, compared with that of the untreated tumor. Anthocyanins 145-156 hematopoietic prostaglandin D synthase Mus musculus 75-100 35508980-8 2022 We selected an MYB family transcription factor to construct overexpression tobacco plants; overexpression of this factor promoted anthocyanin accumulation, turning the leaves purple and increasing their malvidin 3-o-glucoside and petunidin 3-o-glucoside content. Anthocyanins 130-141 uncharacterized protein LOC107775040 Nicotiana tabacum 15-18 35340035-2 2022 Cyanidin-3-O-glucoside (C3G) is the most abundant anthocyanin widely distributed in plants. Anthocyanins 50-61 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 24-27 35491658-2 2022 This browning may be due to the degradation of anthocyanin (AC) in the berries. Anthocyanins 60-62 DDB1 and CUL4 associated factor 7 Homo sapiens 47-58 35467722-0 2022 Thermostability and catechol-O-methyltransferase inhibitory activity of acylated anthocyanins from purple yam. Anthocyanins 81-93 catechol-O-methyltransferase Homo sapiens 20-48 35467722-2 2022 In addition, the inhibitory properties of purple yam and its isolated anthocyanins toward human catechol-O-methyltransferase (COMT), a key neurotransmitter involved in Parkinson"s disease and depression, were also investigated. Anthocyanins 70-82 catechol-O-methyltransferase Homo sapiens 126-130 35216479-6 2022 The ZmARF4 overexpression promoted Pi remobilization and up-regulated AtRNS1, under Pi limitation while it down-regulated the expression of the anthocyanin biosynthesis genes AtDFR and AtANS. Anthocyanins 144-155 Auxin response factor 11 Zea mays 4-10 35408540-0 2022 Preventive Effects of Anthocyanins from Lyciumruthenicum Murray in High-Fat Diet-Induced Obese Mice Are Related to the Regulation of Intestinal Microbiota and Inhibition of Pancreatic Lipase Activity. Anthocyanins 22-34 lipase, endothelial Mus musculus 184-190 35408540-8 2022 The results showed that ACN has a high affinity for pancreatic lipase and inhibits the activity of pancreatic lipase, with IC50 values of 1.80 (main compound anthocyanin) and 3.03 mg/mL (crude extract), in a competitive way. Anthocyanins 158-169 lipase, endothelial Mus musculus 110-116 35408540-10 2022 Taken together, these findings suggest that the anthocyanins from L. ruthenicum fruits could have preventive effects in high-fat-diet induced obese mice by regulating the intestinal microbiota and inhibiting the pancreatic lipase activity. Anthocyanins 48-60 lipase, endothelial Mus musculus 223-229 35406652-0 2022 Overexpression of HLH4 Inhibits Cell Elongation and Anthocyanin Biosynthesis in Arabidopsis thaliana. Anthocyanins 52-63 syntaxin 11 Homo sapiens 18-22 35406652-4 2022 Overexpression of HLH4 causes dwarf and dark green phenotypes and results in the downregulation of many key regulatory and enzymatic genes that participate in the anthocyanin biosynthetic pathway. Anthocyanins 163-174 syntaxin 11 Homo sapiens 18-22 35328800-0 2022 The R3-Type MYB Transcription Factor BrMYBL2.1 Negatively Regulates Anthocyanin Biosynthesis in Chinese Cabbage (Brassica rapa L.) by Repressing MYB-bHLH-WD40 Complex Activity. Anthocyanins 68-79 transcription factor MYB78 Brassica rapa 12-15 35328800-0 2022 The R3-Type MYB Transcription Factor BrMYBL2.1 Negatively Regulates Anthocyanin Biosynthesis in Chinese Cabbage (Brassica rapa L.) by Repressing MYB-bHLH-WD40 Complex Activity. Anthocyanins 68-79 transcription factor MYB78 Brassica rapa 145-148 35328800-2 2022 Here, we identified the R3 MYB transcription factor BrMYBL2.1 as a key negative regulator of anthocyanin biosynthesis. Anthocyanins 93-104 transcription factor MYB78 Brassica rapa 27-30 35294003-0 2022 MtGSTF7, activated by the MYB transcription factor LAP1, specifically participates in anthocyanin accumulation in Medicago truncatula. Anthocyanins 86-97 metallo-aminopeptidase Saccharomyces cerevisiae S288C 51-55 35294003-3 2022 In Arabidopsis thaliana, AtTT19 is necessary for both anthocyanin and PA accumulation. Anthocyanins 54-65 glutathione S-transferase phi 12 Arabidopsis thaliana 25-31 35294003-4 2022 Here, we found that MtGSTF7, a homolog of AtTT19, is essential for anthocyanin accumulation but not required for PA accumulation in Medicago truncatula. Anthocyanins 67-78 glutathione S-transferase phi 12 Arabidopsis thaliana 42-48 35294003-5 2022 MtGSTF7 was induced by the anthocyanin regulator LAP1 and its tissue expression pattern was correlated with anthocyanin deposition in M. truncatula. Anthocyanins 27-38 metallo-aminopeptidase Saccharomyces cerevisiae S288C 49-53 35294003-7 2022 Additionally, the accumulation of anthocyanins induced by LAP1 was significantly blocked in mtgstf7 mutants. Anthocyanins 34-46 metallo-aminopeptidase Saccharomyces cerevisiae S288C 58-62 35288783-0 2022 Blueberry anthocyanin extracts protect against Helicobacter pylori-induced peptic epithelium injuries both in vitro and in vivo: the key role of MAPK/NF-kappaB pathway. Anthocyanins 10-21 nuclear factor kappa B subunit 1 Homo sapiens 150-159 35258172-7 2022 These included MYB110a that encodes a transcription factor regulating anthocyanin biosynthesis. Anthocyanins 70-81 transcription factor MYB114-like Malus domestica 15-22 35212724-9 2022 Intensely pigmented species express all three main MYB anthocyanin activators in petals, whereas pale or white species express few or none. Anthocyanins 55-66 R2R3MYB transcription factor 14 Solanum lycopersicum 51-54 35357376-0 2022 Antihyperglycemic effect of an anthocyanin, cyanidin-3-O-glucoside, is achieved by regulating GLUT-1 via the Wnt/beta-catenin-WISP1 signaling pathway. Anthocyanins 31-42 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 94-100 35357376-0 2022 Antihyperglycemic effect of an anthocyanin, cyanidin-3-O-glucoside, is achieved by regulating GLUT-1 via the Wnt/beta-catenin-WISP1 signaling pathway. Anthocyanins 31-42 catenin (cadherin associated protein), beta 1 Mus musculus 113-125 35357376-0 2022 Antihyperglycemic effect of an anthocyanin, cyanidin-3-O-glucoside, is achieved by regulating GLUT-1 via the Wnt/beta-catenin-WISP1 signaling pathway. Anthocyanins 31-42 cellular communication network factor 4 Mus musculus 126-131 35357376-1 2022 Cyanidin-3-O-glucoside (C3G), an essential representative of anthocyanins, has been proved to possess a myriad of biological activities. Anthocyanins 61-73 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 24-27 35380573-7 2022 Cross-sectionally, significant beneficial associations were observed for intakes of total flavonoids and the flavan-3-ol-monomer, proanthocyanidin, flavonol and anthocyanidin subclasses with measures of glucose tolerance and insulin sensitivity (P < 0.05 for all), except fasting plasma glucose. Anthocyanins 161-174 insulin Homo sapiens 225-232 35436372-2 2022 Here, we identified a T-DNA insertion mutant of Sorting Nexin1 (SNX1), which had more Pi content and less anthocyanin accumulation than the wild-type under deficient Pi. Anthocyanins 106-117 sorting nexin 1 Arabidopsis thaliana 48-62 35436372-2 2022 Here, we identified a T-DNA insertion mutant of Sorting Nexin1 (SNX1), which had more Pi content and less anthocyanin accumulation than the wild-type under deficient Pi. Anthocyanins 106-117 sorting nexin 1 Arabidopsis thaliana 64-68 35395726-10 2022 NsMYB1 was close to the AtMYB114, AtMYB113 and AtPAP1, regulating anthocyanin biosynthesis, in phylogenetic relationship. Anthocyanins 66-77 phosphatidic acid phosphatase 1 Arabidopsis thaliana 47-53 35453434-1 2022 Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin abundant in fruits and vegetables that interacts and possibly modulates energy metabolism and oxidative stress. Anthocyanins 42-53 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 24-27 35398515-0 2022 Systems biology-based analysis indicates that PHO1;H10 positively modulates high light-induced anthocyanin biosynthesis in Arabidopsis leaves. Anthocyanins 95-106 phosphate 1 Arabidopsis thaliana 46-50 35398515-4 2022 We did wet-lab experiments, and found that the detached leaves of PHO1;H10 overexpression lines accumulated more anthocyanin than WT and mutant under high light treatment. Anthocyanins 113-124 phosphate 1 Arabidopsis thaliana 66-70 35398515-5 2022 RNA-seq results showed overexpression of PHO1;H10 up-regulated many anthocyanin biosynthetic genes. Anthocyanins 68-79 phosphate 1 Arabidopsis thaliana 41-45 35398515-7 2022 In summary, we conducted systems biology approach, combining dry- and wet-lab analyses, and discovered that PHO1;H10 plays essential role during modulating high light-induced anthocyanin accumulation in the Arabidopsis detached leaves. Anthocyanins 175-186 phosphate 1 Arabidopsis thaliana 108-112 35418273-0 2022 Statement of Retraction: Role of Blueberry Anthocyanin Extract in the Expression of SIRT1 and NF-kappaB in Rat Lens Epithelial Cells in Experimentally Induced DM. Anthocyanins 43-54 sirtuin 1 Rattus norvegicus 84-89 35337572-3 2022 The highest contents of ascorbic acid and anthocyanins were recorded in blue LED light treated broccoli sprouts. Anthocyanins 42-54 small integral membrane protein 10 like 2A Homo sapiens 77-80 35397147-0 2022 Inhibition of alpha-amylase and alpha-glucosidase by Morus australis fruit extract and its components iminosugar, anthocyanin, and glucose. Anthocyanins 114-125 sucrase-isomaltase Homo sapiens 32-49 35397147-10 2022 Our results that 1-DNJ and anthocyanin are present in Morus australis fruit and are involved in the inhibition of alpha-amylase and alpha-glucosidase suggest that M. australis fruit is a healthy sweetener. Anthocyanins 27-38 sucrase-isomaltase Homo sapiens 132-149 35406945-6 2022 ABCC transporters and to a lower extend MATE transporters sequester anthocyanins into the vacuole. Anthocyanins 68-80 ATP binding cassette subfamily C member 1 Homo sapiens 0-4 35184755-2 2022 Glutathione S-transferases (GSTs), such as the TT19 protein in Arabidopsis, have been implicated in the transport of anthocyanidins during the synthesis of the brown proanthocyanidins. Anthocyanins 117-131 glutathione S-transferase phi 12 Arabidopsis thaliana 47-51 35163816-0 2022 Overexpression of MdZAT5, an C2H2-Type Zinc Finger Protein, Regulates Anthocyanin Accumulation and Salt Stress Response in Apple Calli and Arabidopsis. Anthocyanins 70-81 C2H2-type zinc finger protein Arabidopsis thaliana 29-58 35048920-3 2022 Cyanidin-3-O-glucoside (C3G), a bioactive compound of the anthocyanin family, possesses a variety of functional effects including anti-oxidant and anti-inflammatory, as well as gut microbiota modulation. Anthocyanins 58-69 Rap guanine nucleotide exchange factor 1 Homo sapiens 24-27 35414860-8 2022 Transcriptome analysis showed that the anthocyanin metabolism-related structural genes DFR, ANS and UGT and the transcription factor genes PAP2, TT8, GL3, EGL3 and TTG1 were upregulated in purplish versus white curds. Anthocyanins 39-50 dihydroflavonol-4-reductase Brassica oleracea 87-90 35414860-8 2022 Transcriptome analysis showed that the anthocyanin metabolism-related structural genes DFR, ANS and UGT and the transcription factor genes PAP2, TT8, GL3, EGL3 and TTG1 were upregulated in purplish versus white curds. Anthocyanins 39-50 transcription factor TT8 Brassica oleracea 145-148 35414860-8 2022 Transcriptome analysis showed that the anthocyanin metabolism-related structural genes DFR, ANS and UGT and the transcription factor genes PAP2, TT8, GL3, EGL3 and TTG1 were upregulated in purplish versus white curds. Anthocyanins 39-50 protein TRANSPARENT TESTA GLABRA 1 Brassica oleracea 164-168 17246338-1 1986 The bronze (bz) locus in maize, located in the short arm of chromosome 9 (9S), is the structural gene for the anthocyanin biosynthetic enzyme UFGT. Anthocyanins 110-121 anthocyanidin 3-O-glucosyltransferase Zea mays 4-10 35044756-4 2022 In the mouse model, combined treatment (50 and 100 mg/kg metformin + anthocyanin groups) demonstrated synergistic restorative effects on the blood glucose level, insulin resistance, and organ damage in the liver, pancreas, and ileum. Anthocyanins 69-80 insulin Homo sapiens 162-169 35044756-5 2022 Additionally, combined metformin and anthocyanin treatment suppressed protein tyrosine phosphatase 1B expression and regulated the PI3K/AKT/GSK3beta pathway. Anthocyanins 37-48 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 70-101 35044756-5 2022 Additionally, combined metformin and anthocyanin treatment suppressed protein tyrosine phosphatase 1B expression and regulated the PI3K/AKT/GSK3beta pathway. Anthocyanins 37-48 AKT serine/threonine kinase 1 Homo sapiens 136-139 35044756-5 2022 Additionally, combined metformin and anthocyanin treatment suppressed protein tyrosine phosphatase 1B expression and regulated the PI3K/AKT/GSK3beta pathway. Anthocyanins 37-48 glycogen synthase kinase 3 alpha Homo sapiens 140-148 35067314-2 2022 WRKY41 has been shown to repress anthocyanins synthesis in Arabidopsis, but its full roles in regulating plant phenylpropanoids metabolism still remains to be further studied. Anthocyanins 33-45 WRKY family transcription factor Arabidopsis thaliana 0-6 34651644-5 2022 Both FBN2 and FBN1s interact with allene oxide synthase (AOS), and the elimination of any of these FBNs results in a delay in jasmonate-mediated anthocyanin accumulation in response to a combination of moderate high light and low temperature. Anthocyanins 145-156 allene oxide synthase Arabidopsis thaliana 57-60 35039839-3 2022 In this study, we show that transgenic apple plants over-expressing miR172 show a reduction in red coloration and anthocyanin accumulation in various tissue types. Anthocyanins 114-125 MIR172a Arabidopsis thaliana 68-74 35039839-7 2022 In Arabidopsis, over-expression of miR172 reduced flavonoid (including anthocyanins and flavonols) concentration and RNA transcript abundance of flavonoid genes in plantlets cultured on medium containing 7% sucrose. Anthocyanins 71-83 MIR172a Arabidopsis thaliana 35-41 35056697-6 2022 A RT-qPCR analysis revealed higher transcriptions of key genes related to anthocyanin biosynthesis in Urumqi grape berries, which was consistent with the more abundant phenolic substances, especially anthocyanins. Anthocyanins 200-212 DDB1 and CUL4 associated factor 7 Homo sapiens 74-85 34974624-5 2022 Eight-day-old aox1a/ucp1 seedlings were more sensitive to low N than Col-0 and single mutants, exhibiting lower primary root length and higher anthocyanin accumulation. Anthocyanins 143-154 alternative oxidase 1A Arabidopsis thaliana 14-19 34974624-5 2022 Eight-day-old aox1a/ucp1 seedlings were more sensitive to low N than Col-0 and single mutants, exhibiting lower primary root length and higher anthocyanin accumulation. Anthocyanins 143-154 plant uncoupling mitochondrial protein 1 Arabidopsis thaliana 20-24 2828160-1 1987 Sequences of Bronze2 (Bz2), a maize gene which is required for the synthesis of the purple pigment anthocyanin, have been cloned by combining the techniques of transposon tagging and differential hybridization. Anthocyanins 99-110 glutathione S-transferase Zea mays 13-20 2828160-1 1987 Sequences of Bronze2 (Bz2), a maize gene which is required for the synthesis of the purple pigment anthocyanin, have been cloned by combining the techniques of transposon tagging and differential hybridization. Anthocyanins 99-110 glutathione S-transferase Zea mays 22-25 2828160-5 1987 Because much is known about the genetic requirements for the synthesis of anthocyanin in different tissues, we were able to identify the bz2 clone based on its hybridization to RNA isolated from different bz2 mutants. Anthocyanins 74-85 glutathione S-transferase Zea mays 137-140 3475069-2 1987 Cyanidin 3-rutinoside, a simple anthocyanin, (+)-catechin, a flavanol, and carmoisine, a synthetic food colorant, were found to be particularly potent, reversible inhibitors of PST P. All inhibited this enzyme by 100% at a concentration of 5 microM and had an IC50 in the microM range. Anthocyanins 32-43 sulfotransferase family 1A member 1 Homo sapiens 177-180 3475069-4 1987 There was a considerable difference in the inhibitory ability of different purified anthocyanins but all were selective for PST P. Several other phenolic food colorants were also found to be specific inhibitors of PST P, though less potent in their actions. Anthocyanins 84-96 sulfotransferase family 1A member 1 Homo sapiens 214-217 3025847-9 1986 RNA blot hybridization analysis of three C1 alleles indicates that C1 regulation of the Bz1 and A1 structural genes in the anthocyanin biosynthetic pathway is at the transcriptional level. Anthocyanins 123-134 anthocyanidin 3-O-glucosyltransferase Zea mays 88-91 35142137-0 2022 (Cloning, structure analysis and functional verification of MYB10 in Ribes L.) This study aims to investigate the molecular mechanism of the transcription factor MYB10, which is involved in anthocyanin biosynthesis, in different colors of Ribes L. fruitification. Anthocyanins 190-201 myb domain protein 10 Arabidopsis thaliana 162-167 35093693-9 2022 We further demonstrated the transcriptional regulation of VvCCoAOMT4 by VvMYBA1, a master regulator of grape berry anthocyanin, and verified the protein localization of VvCCoAOMT4 in membrane and nucleus. Anthocyanins 115-126 MYBA1 Vitis vinifera 72-79 35047628-3 2022 As a key enzyme in the biosynthesis of anthocyanidins, dihydroflavonol 4-reductase (DFR) catalyzes the reduction of dihydroflavonols to generate the precursors for anthocyanidins (i.e., leucoanthocyanidins) and anthocyanins. Anthocyanins 39-53 dihydroflavonol-4-reductase Nicotiana tabacum 55-82 35047628-3 2022 As a key enzyme in the biosynthesis of anthocyanidins, dihydroflavonol 4-reductase (DFR) catalyzes the reduction of dihydroflavonols to generate the precursors for anthocyanidins (i.e., leucoanthocyanidins) and anthocyanins. Anthocyanins 39-53 dihydroflavonol-4-reductase Nicotiana tabacum 84-87 35047628-3 2022 As a key enzyme in the biosynthesis of anthocyanidins, dihydroflavonol 4-reductase (DFR) catalyzes the reduction of dihydroflavonols to generate the precursors for anthocyanidins (i.e., leucoanthocyanidins) and anthocyanins. Anthocyanins 164-178 dihydroflavonol-4-reductase Nicotiana tabacum 55-82 35047628-3 2022 As a key enzyme in the biosynthesis of anthocyanidins, dihydroflavonol 4-reductase (DFR) catalyzes the reduction of dihydroflavonols to generate the precursors for anthocyanidins (i.e., leucoanthocyanidins) and anthocyanins. Anthocyanins 164-178 dihydroflavonol-4-reductase Nicotiana tabacum 84-87 35047628-3 2022 As a key enzyme in the biosynthesis of anthocyanidins, dihydroflavonol 4-reductase (DFR) catalyzes the reduction of dihydroflavonols to generate the precursors for anthocyanidins (i.e., leucoanthocyanidins) and anthocyanins. Anthocyanins 186-205 dihydroflavonol-4-reductase Nicotiana tabacum 55-82 35047628-3 2022 As a key enzyme in the biosynthesis of anthocyanidins, dihydroflavonol 4-reductase (DFR) catalyzes the reduction of dihydroflavonols to generate the precursors for anthocyanidins (i.e., leucoanthocyanidins) and anthocyanins. Anthocyanins 186-205 dihydroflavonol-4-reductase Nicotiana tabacum 84-87 35047628-3 2022 As a key enzyme in the biosynthesis of anthocyanidins, dihydroflavonol 4-reductase (DFR) catalyzes the reduction of dihydroflavonols to generate the precursors for anthocyanidins (i.e., leucoanthocyanidins) and anthocyanins. Anthocyanins 211-223 dihydroflavonol-4-reductase Nicotiana tabacum 55-82 35047628-3 2022 As a key enzyme in the biosynthesis of anthocyanidins, dihydroflavonol 4-reductase (DFR) catalyzes the reduction of dihydroflavonols to generate the precursors for anthocyanidins (i.e., leucoanthocyanidins) and anthocyanins. Anthocyanins 211-223 dihydroflavonol-4-reductase Nicotiana tabacum 84-87 35066501-0 2022 Anthocyanins Inhibit Airway Inflammation by Downregulating the NF-kappaB Pathway via the miR-138-5p/SIRT1 Axis in Asthmatic Mice. Anthocyanins 0-12 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 63-72 35066501-0 2022 Anthocyanins Inhibit Airway Inflammation by Downregulating the NF-kappaB Pathway via the miR-138-5p/SIRT1 Axis in Asthmatic Mice. Anthocyanins 0-12 sirtuin 1 Mus musculus 100-105 35066501-3 2022 This study explored the mechanism of anthocyanins on airway inflammation in asthmatic mice by regulating nuclear factor-kappaB (NF-kappaB) via the miR-138-5p/sirtuin-1 (SIRT1) axis. Anthocyanins 37-49 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 105-126 35066501-3 2022 This study explored the mechanism of anthocyanins on airway inflammation in asthmatic mice by regulating nuclear factor-kappaB (NF-kappaB) via the miR-138-5p/sirtuin-1 (SIRT1) axis. Anthocyanins 37-49 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 128-137 35066501-3 2022 This study explored the mechanism of anthocyanins on airway inflammation in asthmatic mice by regulating nuclear factor-kappaB (NF-kappaB) via the miR-138-5p/sirtuin-1 (SIRT1) axis. Anthocyanins 37-49 sirtuin 1 Mus musculus 147-167 35066501-3 2022 This study explored the mechanism of anthocyanins on airway inflammation in asthmatic mice by regulating nuclear factor-kappaB (NF-kappaB) via the miR-138-5p/sirtuin-1 (SIRT1) axis. Anthocyanins 37-49 sirtuin 1 Mus musculus 169-174 35066501-7 2022 RESULTS: In vivo experiments showed that anthocyanins could reduce the OVA-induced airway hyperresponsiveness and airway inflammation, improve the inflammatory infiltration and mucus in lung tissues, and diminish the miR-138-5p level in asthmatic mice. Anthocyanins 41-53 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 71-74 35066501-9 2022 In vitro experiments showed that in HBE cells exposed to OVA, anthocyanins reduced the miR-138-5p level, increased the SIRT1 level, inhibited the release of inflammatory factors, and reduced the nuclear translocation of NF-kappaB p65. Anthocyanins 62-74 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 57-60 35066501-9 2022 In vitro experiments showed that in HBE cells exposed to OVA, anthocyanins reduced the miR-138-5p level, increased the SIRT1 level, inhibited the release of inflammatory factors, and reduced the nuclear translocation of NF-kappaB p65. Anthocyanins 62-74 sirtuin 1 Mus musculus 119-124 35066501-12 2022 CONCLUSION: Anthocyanins inhibited the NF-kappaB pathway by regulating the miR-138-5p/SIRT1 axis, thus inhibiting airway inflammation in asthmatic mice. Anthocyanins 12-24 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 39-48 35066501-12 2022 CONCLUSION: Anthocyanins inhibited the NF-kappaB pathway by regulating the miR-138-5p/SIRT1 axis, thus inhibiting airway inflammation in asthmatic mice. Anthocyanins 12-24 sirtuin 1 Mus musculus 86-91 2776216-3 1989 In the absence of light, these Arabidopsis thaliana mutants, designated det1 (de-etiolated 1), constitutively display many characteristics that are light-dependent in wild-type plants, including leaf and chloroplast development, anthocyanin accumulation, and accumulation of mRNAs for several light-regulated nuclear and chloroplast genes. Anthocyanins 229-240 light-mediated development protein 1 / deetiolated1 (DET1) Arabidopsis thaliana 72-76 2776216-3 1989 In the absence of light, these Arabidopsis thaliana mutants, designated det1 (de-etiolated 1), constitutively display many characteristics that are light-dependent in wild-type plants, including leaf and chloroplast development, anthocyanin accumulation, and accumulation of mRNAs for several light-regulated nuclear and chloroplast genes. Anthocyanins 229-240 light-mediated development protein 1 / deetiolated1 (DET1) Arabidopsis thaliana 78-92 16594066-5 1989 These constructs were introduced into aleurones of genotypes carrying either dominant or recessive alleles of the C1 and R genes, which are known to regulate anthocyanin production. Anthocyanins 158-169 anthocyanin regulatory C1 protein Zea mays 114-122 12359900-7 1989 Expression of C1, a regulatory gene for the anthocyanin pathway, is selectively blocked at the mRNA level in vp1 mutant seed tissues, indicating the Vp1 may control the anthocyanin pathway by regulating C1. Anthocyanins 44-55 regulatory protein viviparous-1 Zea mays 109-112 12359900-7 1989 Expression of C1, a regulatory gene for the anthocyanin pathway, is selectively blocked at the mRNA level in vp1 mutant seed tissues, indicating the Vp1 may control the anthocyanin pathway by regulating C1. Anthocyanins 44-55 regulatory protein viviparous-1 Zea mays 149-152 12359900-7 1989 Expression of C1, a regulatory gene for the anthocyanin pathway, is selectively blocked at the mRNA level in vp1 mutant seed tissues, indicating the Vp1 may control the anthocyanin pathway by regulating C1. Anthocyanins 169-180 regulatory protein viviparous-1 Zea mays 109-112 12359900-7 1989 Expression of C1, a regulatory gene for the anthocyanin pathway, is selectively blocked at the mRNA level in vp1 mutant seed tissues, indicating the Vp1 may control the anthocyanin pathway by regulating C1. Anthocyanins 169-180 regulatory protein viviparous-1 Zea mays 149-152 17248729-2 1976 Phenotypic expression in the plant material involves distinctive variegation patterns of anthocyanin distribution in floral tissues.-The data are consistent with the hypothesis that the genetic constitution of variegated-3 includes a unique and independently segregating regulator component, Flt(3), in addition to the v locus element held in common with variegated-1. Anthocyanins 89-100 fms related receptor tyrosine kinase 1 Homo sapiens 292-295 16664081-1 1985 The viviparous-1 (vp1) mutation in maize (Zea mays L.) conditions a unique pleiotropic phenotype: premature germination of the embryo and failure to synthesize anthocyanin (flavonoid) pigments in the aleurone. Anthocyanins 160-171 regulatory protein viviparous-1 Zea mays 4-16 16664081-1 1985 The viviparous-1 (vp1) mutation in maize (Zea mays L.) conditions a unique pleiotropic phenotype: premature germination of the embryo and failure to synthesize anthocyanin (flavonoid) pigments in the aleurone. Anthocyanins 160-171 regulatory protein viviparous-1 Zea mays 18-21 33873144-6 2021 This may be a result of the MYB and bHLH co-regulate anthocyanins biosynthesis and Se metabolism at the transcriptional level. Anthocyanins 53-65 MYB proto-oncogene, transcription factor Homo sapiens 28-31 24424981-3 1973 Dt causes the inherited change from the recessive a 1 (colorless) to its dominant allele, A 1 (anthocyanin production), during the development of the stalk, leaves, and endosperm. Anthocyanins 95-106 dihydroflavonol 4-reductase Zea mays 90-93 33714113-4 2021 Nine anthocyanins were identified from the ANF using UPLC-Triple-TOF/MS analysis, and cyanidin-3-[2""-(6"""-coumaroyl)-glucosyl]-glucoside (C3G) is the most abundant anthocyanin (87.06%). Anthocyanins 5-17 natriuretic peptide A Rattus norvegicus 43-46 33714113-4 2021 Nine anthocyanins were identified from the ANF using UPLC-Triple-TOF/MS analysis, and cyanidin-3-[2""-(6"""-coumaroyl)-glucosyl]-glucoside (C3G) is the most abundant anthocyanin (87.06%). Anthocyanins 5-16 natriuretic peptide A Rattus norvegicus 43-46 33502632-0 2021 Genome-Wide Mining of MYB Transcription Factors in the Anthocyanin Biosynthesis Pathway of Gossypium Hirsutum. Anthocyanins 55-66 uncharacterized protein LOC107909337 Gossypium hirsutum 22-25 33502632-3 2021 In this study, using a hidden Markov model search and co-expression regulatory network analysis, we demonstrated a process to screen and identify potential MYB TFs in the anthocyanin biosynthesis pathway of Gossypium hirsutum. Anthocyanins 171-182 uncharacterized protein LOC107909337 Gossypium hirsutum 156-159 33502632-5 2021 Using 126 structural genes involved in the anthocyanin biosynthesis pathway as targets for several co-expression network analyses, we sorted out 31 R2R3-MYB genes, which are potential regulators in the specific pathway. Anthocyanins 43-54 uncharacterized protein LOC107909337 Gossypium hirsutum 153-156 32930848-0 2021 Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: a randomized controlled trial. Anthocyanins 0-12 complement factor D Homo sapiens 28-35 32930848-0 2021 Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: a randomized controlled trial. Anthocyanins 0-12 nicotinamide phosphoribosyltransferase Homo sapiens 40-48 32930848-2 2021 This is the first study to investigate the effects of supplementation with purified anthocyanins on serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes. Anthocyanins 84-96 complement factor D Homo sapiens 106-113 32930848-2 2021 This is the first study to investigate the effects of supplementation with purified anthocyanins on serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes. Anthocyanins 84-96 nicotinamide phosphoribosyltransferase Homo sapiens 118-126 32930848-8 2021 CONCLUSION: Purified anthocyanins supplementation for 12 weeks increased serum adipsin and decreased serum visfatin in patients with prediabetes or newly diagnosed diabetes. Anthocyanins 21-33 complement factor D Homo sapiens 79-86 32930848-8 2021 CONCLUSION: Purified anthocyanins supplementation for 12 weeks increased serum adipsin and decreased serum visfatin in patients with prediabetes or newly diagnosed diabetes. Anthocyanins 21-33 nicotinamide phosphoribosyltransferase Homo sapiens 107-115 33837934-12 2021 CONCLUSION: Difference in the C-terminal region of BoLBD37L-G and BolBD37L-P may affect the expression of downstream genes, BoMYB114L and BoTT8, resulting in differential anthocyanin accumulation. Anthocyanins 171-182 transcription factor TT8 Brassica oleracea 138-143 34052932-0 2021 High promoter sequence variation in subgroup 6 members of R2R3-MYB genes is involved in different floral anthocyanin color patterns in Lilium spp. Anthocyanins 105-116 uncharacterized protein LOC107775040 Nicotiana tabacum 63-66 33316711-5 2021 The addition of vitamin C into the protein-anthocyanin solutions accelerated the color loss of C3G, whereas EGCG and gallic acid improved its thermal stability. Anthocyanins 43-54 Rap guanine nucleotide exchange factor 1 Homo sapiens 95-98 34052932-1 2021 The spatially and temporally distinct expression of R2R3-MYB positive regulators is among the major mechanisms that create various anthocyanin color patterns in many flowers. Anthocyanins 131-142 uncharacterized protein LOC107775040 Nicotiana tabacum 57-60 34049482-0 2021 The transcription factor AtGLK1 acts upstream of MYBL2 to genetically regulate sucrose-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 95-106 GBF's pro-rich region-interacting factor 1 Arabidopsis thaliana 25-31 34049482-0 2021 The transcription factor AtGLK1 acts upstream of MYBL2 to genetically regulate sucrose-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 95-106 MYB-like 2 Arabidopsis thaliana 49-54 34049482-2 2021 Here experimental evidence was provided in order to demonstrate that the nuclear GARP transcription factor AtGLK1 plays an important role in regulating sucrose-induced anthocyanin biosynthesis in Arabidopsis. Anthocyanins 168-179 GBF's pro-rich region-interacting factor 1 Arabidopsis thaliana 107-113 34049482-4 2021 The loss-of-function glk1 glk2 double mutant has lower anthocyanin levels than the glk2 single mutant, although it has been determined that loss of AtGLK1 alone does not affect anthocyanin accumulation. Anthocyanins 55-66 GBF's pro-rich region-interacting factor 1 Arabidopsis thaliana 21-25 34049482-4 2021 The loss-of-function glk1 glk2 double mutant has lower anthocyanin levels than the glk2 single mutant, although it has been determined that loss of AtGLK1 alone does not affect anthocyanin accumulation. Anthocyanins 55-66 GOLDEN2-like 2 Arabidopsis thaliana 26-30 34049482-5 2021 Overexpression of AtGLK1 enhances the accumulation of anthocyanin in transgenic Arabidopsis seedlings accompanied by increased expression of anthocyanin biosynthetic and regulatory genes. Anthocyanins 54-65 GBF's pro-rich region-interacting factor 1 Arabidopsis thaliana 18-24 34049482-5 2021 Overexpression of AtGLK1 enhances the accumulation of anthocyanin in transgenic Arabidopsis seedlings accompanied by increased expression of anthocyanin biosynthetic and regulatory genes. Anthocyanins 141-152 GBF's pro-rich region-interacting factor 1 Arabidopsis thaliana 18-24 34049482-6 2021 Moreover, we found that AtGLK1 also participates in plastid-signaling mediated anthocyanin accumulations. Anthocyanins 79-90 GBF's pro-rich region-interacting factor 1 Arabidopsis thaliana 24-30 34049482-7 2021 Genetic, physiological, and molecular biological approaches demonstrated that AtGLK1 acts upstream of MYBL2, which is a key negative regulator of anthocyanin biosynthesis, to genetically regulate sucrose-induced anthocyanin biosynthesis. Anthocyanins 146-157 GBF's pro-rich region-interacting factor 1 Arabidopsis thaliana 78-84 34049482-7 2021 Genetic, physiological, and molecular biological approaches demonstrated that AtGLK1 acts upstream of MYBL2, which is a key negative regulator of anthocyanin biosynthesis, to genetically regulate sucrose-induced anthocyanin biosynthesis. Anthocyanins 146-157 MYB-like 2 Arabidopsis thaliana 102-107 34049482-7 2021 Genetic, physiological, and molecular biological approaches demonstrated that AtGLK1 acts upstream of MYBL2, which is a key negative regulator of anthocyanin biosynthesis, to genetically regulate sucrose-induced anthocyanin biosynthesis. Anthocyanins 212-223 GBF's pro-rich region-interacting factor 1 Arabidopsis thaliana 78-84 34049482-7 2021 Genetic, physiological, and molecular biological approaches demonstrated that AtGLK1 acts upstream of MYBL2, which is a key negative regulator of anthocyanin biosynthesis, to genetically regulate sucrose-induced anthocyanin biosynthesis. Anthocyanins 212-223 MYB-like 2 Arabidopsis thaliana 102-107 34049482-8 2021 CONCLUSION: Our results indicated that AtGLK1 positively regulates sucrose-induced anthocyanin biosynthesis in Arabidopsis via MYBL2. Anthocyanins 83-94 GBF's pro-rich region-interacting factor 1 Arabidopsis thaliana 39-45 34049482-8 2021 CONCLUSION: Our results indicated that AtGLK1 positively regulates sucrose-induced anthocyanin biosynthesis in Arabidopsis via MYBL2. Anthocyanins 83-94 MYB-like 2 Arabidopsis thaliana 127-132 34044544-0 2021 Effects of alpha-Casein on the Absorption of Blueberry Anthocyanins and Metabolites in Rat Plasma Based on Pharmacokinetic Analysis. Anthocyanins 55-67 casein alpha s1 Rattus norvegicus 11-23 34044544-3 2021 Our current study aimed to detect the effects of alpha-casein on the absorption of blueberry anthocyanins and their metabolites in rats. Anthocyanins 93-105 casein alpha s1 Rattus norvegicus 49-61 34044544-5 2021 With the complexation of alpha-casein, the maximum concentration (Cmax) of bioavailable anthocyanins and metabolites could increase by 1.5-10.1 times (P < 0.05 or P < 0.01). Anthocyanins 88-100 casein alpha s1 Rattus norvegicus 25-37 34044544-7 2021 Besides, the molecular docking models presented that anthocyanins could enter the structural cavity and interact with amino acid residues of alpha-casein, which was in accordance with the improved bioavailability of anthocyanins. Anthocyanins 53-65 casein alpha s1 Rattus norvegicus 141-153 34044544-7 2021 Besides, the molecular docking models presented that anthocyanins could enter the structural cavity and interact with amino acid residues of alpha-casein, which was in accordance with the improved bioavailability of anthocyanins. Anthocyanins 216-228 casein alpha s1 Rattus norvegicus 141-153 34044544-8 2021 Therefore, alpha-casein could assist more blueberry anthocyanins and their metabolites to enter blood circulation. Anthocyanins 52-64 casein alpha s1 Rattus norvegicus 11-23 34034660-7 2021 Furthermore, our results show that expression of OsTTG1A in the ttg1 mutant restored the phenotypes including alternations in trichome and root hair formation, seed color, mucilage production and anthocyanin biosynthesis, indicating that OsTTG1A and TTG1 may have similar functions. Anthocyanins 196-207 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 51-55 33171489-8 2021 Yeast one-hybrid assays revealed that MdLUX and MdPCL-like may bind to the promoter region of the anthocyanin biosynthesis gene MdF3H. Anthocyanins 98-109 naringenin,2-oxoglutarate 3-dioxygenase-like Malus domestica 128-133 33652057-11 2021 Specifically, numerous NPs including flavonoids, gingerols, tannins, anthocyanins, triterpenes and alkaloids have been shown anti-inflammatory, antioxidant, anti-amyloidogenic, and anti-choLinesterase properties. Anthocyanins 69-81 butyrylcholinesterase Homo sapiens 186-200 34046684-2 2021 In Arabidopsis (Arabidopsis thaliana), cryptochrome 1 (CRY1) mediates blue light-induced photomorphogenesis, which is characterized by reduced hypocotyl elongation and enhanced anthocyanin production, whereas gibberellin (GA) signaling mediated by the GA receptor GA-INSENSITIVE DWARF1 (GID1) and DELLA proteins promotes hypocotyl elongation and inhibits anthocyanin accumulation. Anthocyanins 177-188 cryptochrome 1 Arabidopsis thaliana 39-53 34046684-2 2021 In Arabidopsis (Arabidopsis thaliana), cryptochrome 1 (CRY1) mediates blue light-induced photomorphogenesis, which is characterized by reduced hypocotyl elongation and enhanced anthocyanin production, whereas gibberellin (GA) signaling mediated by the GA receptor GA-INSENSITIVE DWARF1 (GID1) and DELLA proteins promotes hypocotyl elongation and inhibits anthocyanin accumulation. Anthocyanins 177-188 cryptochrome 1 Arabidopsis thaliana 55-59 34046684-2 2021 In Arabidopsis (Arabidopsis thaliana), cryptochrome 1 (CRY1) mediates blue light-induced photomorphogenesis, which is characterized by reduced hypocotyl elongation and enhanced anthocyanin production, whereas gibberellin (GA) signaling mediated by the GA receptor GA-INSENSITIVE DWARF1 (GID1) and DELLA proteins promotes hypocotyl elongation and inhibits anthocyanin accumulation. Anthocyanins 355-366 cryptochrome 1 Arabidopsis thaliana 39-53 34046684-2 2021 In Arabidopsis (Arabidopsis thaliana), cryptochrome 1 (CRY1) mediates blue light-induced photomorphogenesis, which is characterized by reduced hypocotyl elongation and enhanced anthocyanin production, whereas gibberellin (GA) signaling mediated by the GA receptor GA-INSENSITIVE DWARF1 (GID1) and DELLA proteins promotes hypocotyl elongation and inhibits anthocyanin accumulation. Anthocyanins 355-366 cryptochrome 1 Arabidopsis thaliana 55-59 33676299-4 2021 Here, we identified the R2R3 MYB transcription factor gene PRODUCTION OF ANTHOCYANIN PIGMENT1 (BrPAP1a) as the critical gene in the anthocyanin-defective mutant w68. Anthocyanins 132-143 transcription factor MYB78 Brassica rapa 29-32 33955484-9 2021 dhs1 and dhs3 also had reduced anthocyanin accumulation under high light stress. Anthocyanins 31-42 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 1 Arabidopsis thaliana 0-4 33934247-8 2021 Furthermore, overexpression of VvBBX44 decreased the expression of LONG HYPOCOTYL 5 (VvHY5) and UDP-glucose flavonoid 3-O-glucosyltransferase (VvUFGT), and reduced the anthocyanin content in grape calli. Anthocyanins 168-179 transcription factor HY5 Vitis vinifera 85-90 33787249-6 2021 Further studies unveiled that the representative anthocyanin M3G-upregulated transcription factor EB (TFEB)-mediated lysosomal function possibly interacted with TFEB and activated the Nrf2/ARE (antioxidant responsive element) signaling pathway. Anthocyanins 49-60 transcription factor EB Homo sapiens 102-106 33787249-6 2021 Further studies unveiled that the representative anthocyanin M3G-upregulated transcription factor EB (TFEB)-mediated lysosomal function possibly interacted with TFEB and activated the Nrf2/ARE (antioxidant responsive element) signaling pathway. Anthocyanins 49-60 transcription factor EB Homo sapiens 161-165 33787249-6 2021 Further studies unveiled that the representative anthocyanin M3G-upregulated transcription factor EB (TFEB)-mediated lysosomal function possibly interacted with TFEB and activated the Nrf2/ARE (antioxidant responsive element) signaling pathway. Anthocyanins 49-60 NFE2 like bZIP transcription factor 2 Homo sapiens 184-188 33908060-0 2021 The MdMYB16/MdMYB1-miR7125-MdCCR module regulates the homeostasis between anthocyanin and lignin biosynthesis during light induction in apple. Anthocyanins 74-85 MIR7125 Malus domestica 19-26 33908060-4 2021 In this study, we identified and functionally elucidated the roles of miR7125 and its target, cinnamoyl-coenzyme A reductase gene (CCR), in regulating the homeostasis between anthocyanin and lignin biosynthesis during light induction. Anthocyanins 175-186 MIR7125 Malus domestica 70-77 33908060-5 2021 Overexpressing miR7125 or inhibiting CCR transiently in apple fruit promoted anthocyanin biosynthesis but reduced lignin production under light-induced conditions. Anthocyanins 77-88 MIR7125 Malus domestica 15-22 33908060-10 2021 The results reveal a novel mechanism by which the MdMYB16/MdMYB1-miR7125-MdCCR module collaboratively regulates homeostasis between anthocyanin and lignin biosynthesis under light induction in apple. Anthocyanins 132-143 MIR7125 Malus domestica 65-72 33835816-5 2021 Both anthocyanin extracts restored the levels of multiple metabolites (glucose, lactate, alanine, and pyruvate) and expression of genes (G6pac, Pck1, Pklr, and Gck) involved in glycolysis and gluconeogenesis. Anthocyanins 5-16 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 144-148 33835816-5 2021 Both anthocyanin extracts restored the levels of multiple metabolites (glucose, lactate, alanine, and pyruvate) and expression of genes (G6pac, Pck1, Pklr, and Gck) involved in glycolysis and gluconeogenesis. Anthocyanins 5-16 pyruvate kinase L/R Rattus norvegicus 150-154 33835816-5 2021 Both anthocyanin extracts restored the levels of multiple metabolites (glucose, lactate, alanine, and pyruvate) and expression of genes (G6pac, Pck1, Pklr, and Gck) involved in glycolysis and gluconeogenesis. Anthocyanins 5-16 glucokinase Rattus norvegicus 160-163 33676299-10 2021 Collectively, our data indicate the importance of the highly conserved amino acids within R2R3 MYB proteins in regulating anthocyanin biosynthesis and could aid programs to increase anthocyanins in turnip roots. Anthocyanins 122-133 transcription factor MYB78 Brassica rapa 95-98 33676299-10 2021 Collectively, our data indicate the importance of the highly conserved amino acids within R2R3 MYB proteins in regulating anthocyanin biosynthesis and could aid programs to increase anthocyanins in turnip roots. Anthocyanins 182-194 transcription factor MYB78 Brassica rapa 95-98 33835607-0 2021 Apple MPK4 Mediates Phosphorylation of MYB1 to Enhance Light-Induced Anthocyanin Accumulation. Anthocyanins 69-80 transcription factor MYB86-like Malus domestica 39-43 33834197-0 2021 Experimental Evidence that (-)-Epicatechin and Anthocyanins Modulate Glucagon-Like Peptide-1 Metabolism: Relevant For Humans? Anthocyanins 47-59 glucagon Homo sapiens 69-92 32648022-8 2021 Continuous glucose monitoring enabled an effect of NZBC extract to be observed under free-living conditions and highlights the potential of anthocyanin-rich supplements as a viable strategy to reduce insulin resistance. Anthocyanins 140-151 insulin Homo sapiens 200-207 33790254-0 2021 Genomic analysis uncovers functional variation in the C-terminus of anthocyanin-activating MYB transcription factors. Anthocyanins 68-79 uncharacterized protein LOC107775040 Nicotiana tabacum 91-94 33790254-2 2021 Here, we harness genomic resources to identify novel MYBs, thereby producing an updated eudicot MYB phylogeny with revised relationships among subgroups as well as new information on sequence variation in the disordered C-terminus of anthocyanin-activating MYBs. Anthocyanins 234-245 uncharacterized protein LOC107775040 Nicotiana tabacum 53-56 33790264-5 2021 In addition, genes involved in carotenoid and anthocyanin biosynthesis and ethylene signaling were revealed as direct targets of SlHY5 by chromatin immunoprecipitation. Anthocyanins 46-57 transcription factor HY5 Solanum lycopersicum 129-134 32155282-0 2021 The dietary anthocyanin delphinidin prevents bone resorption by inhibiting Rankl-induced differentiation of osteoclasts in a medaka (Oryzias latipes) model of osteoporosis. Anthocyanins 12-23 tumor necrosis factor ligand superfamily member 11 Oryzias latipes 75-80 32492761-0 2021 Blue and UV-B light synergistically induce anthocyanin accumulation by co-activating nitrate reductase gene expression in Anthocyanin fruit (Aft) tomato. Anthocyanins 43-54 nitrate reductase [NADH] Solanum lycopersicum 85-102 32492761-0 2021 Blue and UV-B light synergistically induce anthocyanin accumulation by co-activating nitrate reductase gene expression in Anthocyanin fruit (Aft) tomato. Anthocyanins 122-133 nitrate reductase [NADH] Solanum lycopersicum 85-102 32492761-6 2021 The functions of NR mediated anthocyanin induction by blue + UV-B were confirmed by a series of chemical treatments, followed with NR activity and nitric oxide (NO) detection. Anthocyanins 29-40 nitrate reductase [NADH] Solanum lycopersicum 17-19 32492761-6 2021 The functions of NR mediated anthocyanin induction by blue + UV-B were confirmed by a series of chemical treatments, followed with NR activity and nitric oxide (NO) detection. Anthocyanins 29-40 nitrate reductase [NADH] Solanum lycopersicum 131-133 32492761-8 2021 NR inhibitors, which diminish NO generation, suppressed the expression of anthocyanin genes and decreased anthocyanin accumulation in LA1996. Anthocyanins 74-85 nitrate reductase [NADH] Solanum lycopersicum 0-2 32492761-8 2021 NR inhibitors, which diminish NO generation, suppressed the expression of anthocyanin genes and decreased anthocyanin accumulation in LA1996. Anthocyanins 106-117 nitrate reductase [NADH] Solanum lycopersicum 0-2 32492761-9 2021 Our results suggest NR plays a key role in blue + UV-B mediated anthocyanin accumulation in LA1996 fruits. Anthocyanins 64-75 nitrate reductase [NADH] Solanum lycopersicum 20-22 33789251-9 2022 Flow cytometric analysis showed a significant effect of AC on the expression of P-selectin as measured by the platelet surface expression of CD62p. Anthocyanins 56-58 selectin P Homo sapiens 80-90 33617039-0 2021 SPX4 interacts with both PHR1 and PAP1 to regulate critical steps in phosphorus-status-dependent anthocyanin biosynthesis. Anthocyanins 97-108 SPX domain-containing protein 4 Arabidopsis thaliana 0-4 33617039-0 2021 SPX4 interacts with both PHR1 and PAP1 to regulate critical steps in phosphorus-status-dependent anthocyanin biosynthesis. Anthocyanins 97-108 photolyase 1 Arabidopsis thaliana 25-29 33617039-0 2021 SPX4 interacts with both PHR1 and PAP1 to regulate critical steps in phosphorus-status-dependent anthocyanin biosynthesis. Anthocyanins 97-108 phosphatidic acid phosphatase 1 Arabidopsis thaliana 34-38 33617039-4 2021 Here, we demonstrate that SPX4, a conserved regulator of the Pi response, transduces the Pi starvation signal to anthocyanin biosynthesis in Arabidopsis. Anthocyanins 113-124 SPX domain-containing protein 4 Arabidopsis thaliana 26-30 33617039-5 2021 When phr1spx4 plants were grown under low Pi conditions, DFR expression and anthocyanin biosynthesis were induced, which distinguished the plant from the behavior reported in the phr1 mutant. Anthocyanins 76-87 photolyase 1 Arabidopsis thaliana 5-13 33617039-5 2021 When phr1spx4 plants were grown under low Pi conditions, DFR expression and anthocyanin biosynthesis were induced, which distinguished the plant from the behavior reported in the phr1 mutant. Anthocyanins 76-87 photolyase 1 Arabidopsis thaliana 5-9 33617039-6 2021 We also provide evidence that SPX4 interacts with PAP1, an MYB transcription factor that controls the anthocyanin biosynthetic pathway, in an inositol polyphosphate-dependent manner. Anthocyanins 102-113 SPX domain-containing protein 4 Arabidopsis thaliana 30-34 33617039-6 2021 We also provide evidence that SPX4 interacts with PAP1, an MYB transcription factor that controls the anthocyanin biosynthetic pathway, in an inositol polyphosphate-dependent manner. Anthocyanins 102-113 phosphatidic acid phosphatase 1 Arabidopsis thaliana 50-54 33617039-7 2021 Through a physical interaction, SPX4 prevented PAP1 from binding to its target gene promoter; by contrast, during Pi-deficient conditions, in the absence of inositol polyphosphates, PAP1 was released from SPX to activate anthocyanin biosynthesis. Anthocyanins 221-232 SPX domain-containing protein 4 Arabidopsis thaliana 32-36 33617039-7 2021 Through a physical interaction, SPX4 prevented PAP1 from binding to its target gene promoter; by contrast, during Pi-deficient conditions, in the absence of inositol polyphosphates, PAP1 was released from SPX to activate anthocyanin biosynthesis. Anthocyanins 221-232 phosphatidic acid phosphatase 1 Arabidopsis thaliana 182-186 33691969-2 2021 Malonyl CoA is an important intermediate in anthocyanin synthesis, and citrate, formed by citrate synthase (CS) catalysing oxaloacetate, is the precursor for the formation of malonyl-CoA. Anthocyanins 44-55 sperm mitochondria-associated cysteine-rich protein Mus musculus 108-110 33789251-9 2022 Flow cytometric analysis showed a significant effect of AC on the expression of P-selectin as measured by the platelet surface expression of CD62p. Anthocyanins 56-58 selectin P Homo sapiens 141-146 33759251-0 2021 Jasmonate induces anthocyanin and proanthocyanidin biosynthesis in apple by mediating the JAZ1-TRB1-MYB9 complex. Anthocyanins 18-29 myb-related protein 308-like Malus domestica 100-104 33759251-7 2021 These results show that the JAZ1-TRB1-MYB9 module dynamically modulates JA-mediated anthocyanin and proanthocyanidin accumulation. Anthocyanins 84-95 myb-related protein 308-like Malus domestica 38-42 33751905-0 2021 Anthocyanin-Rich Aronia Berry Extract Mitigates High-Fat and High-Sucrose Diet-Induced Adipose Tissue Inflammation by Inhibiting Nuclear Factor-kappaB Activation. Anthocyanins 0-11 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 129-150 33757424-9 2021 Moreover, overexpression of Bract1 wild-type allele in Arabidopsis tt19 mutants restored the anthocyanin phenotype, while the Bract1 mutated allele showed to be non-functional. Anthocyanins 93-104 glutathione S-transferase phi 12 Arabidopsis thaliana 67-71 33071012-9 2021 C-reactive protein was lower 4 h postprandially in the anthocyanins (1.80 mg/L, IQR 0.90) vs control arm (2.30 mg/L, IQR 1.95) (P = 0.026), accompanied by a trend for lower concentrations of interleukin-6 (P = 0.075). Anthocyanins 55-67 C-reactive protein Homo sapiens 0-18 33546942-0 2021 Food anthocyanins decrease concentrations of TNF-alpha in older adults with mild cognitive impairment: A randomized, controlled, double blind clinical trial. Anthocyanins 5-17 tumor necrosis factor Homo sapiens 45-54 33546942-6 2021 RESULTS: Participants in the high anthocyanins group had a reduction in serum tumor necrosis factor alpha (TNF-alpha) (P = 0.002) compared to controls and the low anthocyanins group (all P"s > 0.05). Anthocyanins 34-46 tumor necrosis factor Homo sapiens 78-105 33546942-6 2021 RESULTS: Participants in the high anthocyanins group had a reduction in serum tumor necrosis factor alpha (TNF-alpha) (P = 0.002) compared to controls and the low anthocyanins group (all P"s > 0.05). Anthocyanins 34-46 tumor necrosis factor Homo sapiens 107-116 33546942-8 2021 CONCLUSION: A daily high dose of fruit-based anthocyanins for 8 weeks reduced concentrations of TNF-alpha in older adults with MCI. Anthocyanins 45-57 tumor necrosis factor Homo sapiens 96-105 33666540-7 2021 Thyroxine and 3-methyladenine give stability to human transthyretin (TTR) and activate autophagy, respectively, which are associated with the pathogenesis of Alzheimer"s disease.Conclusion: The result shows the potential of TP 3-in-1 juice which is rich in anthocyanins in improving cognitive function, particularly learning, memory, processing speed, sequencing, mental flexibility and visual-motor skills domains, among middle-aged women. Anthocyanins 258-270 transthyretin Homo sapiens 54-67 33693759-0 2021 (-)-Epicatechin and Anthocyanins Modulate GLP-1 Metabolism: Evidence from C57BL/6J Mice and GLUTag Cells. Anthocyanins 20-32 glucagon Mus musculus 42-47 33071012-9 2021 C-reactive protein was lower 4 h postprandially in the anthocyanins (1.80 mg/L, IQR 0.90) vs control arm (2.30 mg/L, IQR 1.95) (P = 0.026), accompanied by a trend for lower concentrations of interleukin-6 (P = 0.075). Anthocyanins 55-67 interleukin 6 Homo sapiens 191-204 33559031-4 2021 Lactate dehydrogenase (LDH) was similarly related to protein concentration although also dependent on both dietary anthocyanins and flight training. Anthocyanins 115-127 L-lactate dehydrogenase B chain Sturnus vulgaris 0-21 33559031-4 2021 Lactate dehydrogenase (LDH) was similarly related to protein concentration although also dependent on both dietary anthocyanins and flight training. Anthocyanins 115-127 L-lactate dehydrogenase B chain Sturnus vulgaris 23-26 32614624-6 2021 Combination of ACNs:PAs decreased gene expression of AKT1 and eNOS, while protein levels of AKT1 increased. Anthocyanins 15-19 nitric oxide synthase 3 Homo sapiens 62-66 33644583-4 2021 Cyanidin-3-O-glucoside (C3G), the most common type of anthocyanin in nature, widely exists in a variety of vegetables and fruits. Anthocyanins 54-65 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 24-27 32614624-5 2021 Endothelial cells exposed to ACNs downregulated gene expression of AKT1 and endothelial nitric oxide synthase (eNOS), while PAs upregulated AKT1 and vascular endothelial growth factor (VEGF) gene expression. Anthocyanins 29-33 AKT serine/threonine kinase 1 Homo sapiens 67-71 32614624-5 2021 Endothelial cells exposed to ACNs downregulated gene expression of AKT1 and endothelial nitric oxide synthase (eNOS), while PAs upregulated AKT1 and vascular endothelial growth factor (VEGF) gene expression. Anthocyanins 29-33 nitric oxide synthase 3 Homo sapiens 76-109 32614624-5 2021 Endothelial cells exposed to ACNs downregulated gene expression of AKT1 and endothelial nitric oxide synthase (eNOS), while PAs upregulated AKT1 and vascular endothelial growth factor (VEGF) gene expression. Anthocyanins 29-33 nitric oxide synthase 3 Homo sapiens 111-115 32614624-5 2021 Endothelial cells exposed to ACNs downregulated gene expression of AKT1 and endothelial nitric oxide synthase (eNOS), while PAs upregulated AKT1 and vascular endothelial growth factor (VEGF) gene expression. Anthocyanins 29-33 vascular endothelial growth factor A Homo sapiens 149-183 32614624-5 2021 Endothelial cells exposed to ACNs downregulated gene expression of AKT1 and endothelial nitric oxide synthase (eNOS), while PAs upregulated AKT1 and vascular endothelial growth factor (VEGF) gene expression. Anthocyanins 29-33 vascular endothelial growth factor A Homo sapiens 185-189 33728019-5 2021 The natural dietary polyflavonoid anthocyanin enhances insulin sensitivity, attenuates insulin resistance at the level of the target tissues, inhibits free fatty acid oxidation, and abrogates the release of peripheral inflammatory cytokines in obese (prediabetic) individuals, which are responsible for insulin resistance, systemic hyperglycemia, systemic inflammation, brain metabolism dyshomeostasis, amyloid-beta accumulation, and neuroinflammatory responses. Anthocyanins 34-45 insulin Homo sapiens 55-62 33728019-5 2021 The natural dietary polyflavonoid anthocyanin enhances insulin sensitivity, attenuates insulin resistance at the level of the target tissues, inhibits free fatty acid oxidation, and abrogates the release of peripheral inflammatory cytokines in obese (prediabetic) individuals, which are responsible for insulin resistance, systemic hyperglycemia, systemic inflammation, brain metabolism dyshomeostasis, amyloid-beta accumulation, and neuroinflammatory responses. Anthocyanins 34-45 insulin Homo sapiens 87-94 33728019-5 2021 The natural dietary polyflavonoid anthocyanin enhances insulin sensitivity, attenuates insulin resistance at the level of the target tissues, inhibits free fatty acid oxidation, and abrogates the release of peripheral inflammatory cytokines in obese (prediabetic) individuals, which are responsible for insulin resistance, systemic hyperglycemia, systemic inflammation, brain metabolism dyshomeostasis, amyloid-beta accumulation, and neuroinflammatory responses. Anthocyanins 34-45 insulin Homo sapiens 87-94 33728019-5 2021 The natural dietary polyflavonoid anthocyanin enhances insulin sensitivity, attenuates insulin resistance at the level of the target tissues, inhibits free fatty acid oxidation, and abrogates the release of peripheral inflammatory cytokines in obese (prediabetic) individuals, which are responsible for insulin resistance, systemic hyperglycemia, systemic inflammation, brain metabolism dyshomeostasis, amyloid-beta accumulation, and neuroinflammatory responses. Anthocyanins 34-45 amyloid beta precursor protein Homo sapiens 403-415 33638982-6 2021 Two classes of LigB homologs have been reported: those found in anthocyanin-producing species and those found in betalain-producing species, which contain DOD. Anthocyanins 64-75 catalytic LigB subunit of aromatic ring-opening dioxygenase family Arabidopsis thaliana 15-19 33638982-7 2021 To gain insight into the evolution of specialized metabolic enzymes involved in betalain biosynthesis, we performed a comparative biochemical analysis of Arabidopsis LigB, an extradiol ring-cleavage dioxygenase in anthocyanin-producing Arabidopsis, and Phytolacca DOD1 of betalain-producing Phytolacca americana. Anthocyanins 214-225 catalytic LigB subunit of aromatic ring-opening dioxygenase family Arabidopsis thaliana 166-170 33159793-0 2021 ABI5 regulates ABA-induced anthocyanin biosynthesis by modulating the MYB1-bHLH3 complex in apple. Anthocyanins 27-38 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 0-4 33159793-0 2021 ABI5 regulates ABA-induced anthocyanin biosynthesis by modulating the MYB1-bHLH3 complex in apple. Anthocyanins 27-38 transcription factor MYB86-like Malus domestica 70-74 33159793-0 2021 ABI5 regulates ABA-induced anthocyanin biosynthesis by modulating the MYB1-bHLH3 complex in apple. Anthocyanins 27-38 basic helix-loop-helix protein A Malus domestica 75-80 33159793-4 2021 Nevertheless, whether ABI5 regulates anthocyanin biosynthesis has not been reported. Anthocyanins 37-48 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 22-26 33159793-5 2021 In this study, we found that MdABI5, the homolog of Arabidopsis ABI5, positively regulated ABA-induced anthocyanin biosynthesis in apple. Anthocyanins 103-114 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 31-35 33159793-12 2021 Our work enriches the functional studies of ABI5 and further broadens the regulatory network of ABA-mediated anthocyanin biosynthesis, providing new insights for further study of the transcriptional regulatory mechanisms of anthocyanin biosynthesis. Anthocyanins 109-120 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 44-48 33159793-12 2021 Our work enriches the functional studies of ABI5 and further broadens the regulatory network of ABA-mediated anthocyanin biosynthesis, providing new insights for further study of the transcriptional regulatory mechanisms of anthocyanin biosynthesis. Anthocyanins 224-235 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 44-48 33527955-0 2021 The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells. Anthocyanins 9-20 phosphatase and tensin homolog Homo sapiens 91-95 33527955-0 2021 The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells. Anthocyanins 9-20 AKT serine/threonine kinase 1 Homo sapiens 101-104 33527955-0 2021 The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells. Anthocyanins 9-20 caspase 3 Homo sapiens 105-114 33669590-0 2021 Ratiometric Fluorescence Assay for Nitroreductase Activity: Locked-Flavylium Fluorophore as a NTR-Sensitive Molecular Probe. Anthocyanins 67-76 neurotensin receptor 1 Homo sapiens 94-97 32317748-6 2021 Compared with placebo, 320 mg/day anthocyanin significantly increased CEC (35.8%, 95% CI: 11.5-60.2%; P = 0.004), HDL-C (0.07 mmol/L, 95% CI: 0.01-0.14; P = 0.003), and ApoA-I (0.07 g/L, 95% CI: 0.01-0.12; P = 0.008). Anthocyanins 34-45 apolipoprotein A1 Homo sapiens 169-175 33578910-6 2021 To better understand the effects of anthocyanins on plant physiology and morphogenesis, and their implications on drought stress tolerance, we used transgenic tobacco plants (AN1), which over-accumulated anthocyanins in all tissues. Anthocyanins 204-216 annexin D1-like Nicotiana tabacum 175-178 33585872-7 2021 A QTL near P1 (Pericarp color1) was found for both flavone content and flavanol-anthocyanin condensed forms. Anthocyanins 80-91 myb-related protein P Zea mays 11-30 33585872-9 2021 Mapping total anthocyanin content produced signals near Aat1, the aleurone-associated bHLH R1 (Colored1), the plant color-associated MYB, Pl1 (Purple plant1), the aleurone-associated recessive intensifier, In1 (Intensifier1), and several previously unidentified candidates. Anthocyanins 14-25 transcription factor BHLH42 Zea mays 206-209 33585872-9 2021 Mapping total anthocyanin content produced signals near Aat1, the aleurone-associated bHLH R1 (Colored1), the plant color-associated MYB, Pl1 (Purple plant1), the aleurone-associated recessive intensifier, In1 (Intensifier1), and several previously unidentified candidates. Anthocyanins 14-25 transcription factor BHLH42 Zea mays 211-223 33547660-0 2021 Functional analysis of MYB alleles from Solanum chilense and Solanum lycopersicum in controlling anthocyanin levels in heterologous tobacco plants. Anthocyanins 97-108 uncharacterized protein LOC107775040 Nicotiana tabacum 23-26 33547660-2 2021 Tobacco plants transformed with an MYB regulatory gene from either Solanum chilense (Sc) or S. lycopersicum (Sl) demonstrate that ScANT1 induces a higher level of anthocyanin accumulation in comparison to SlANT1 and that this gene is sufficient to promote increased anthocyanin levels. Anthocyanins 163-174 uncharacterized protein LOC107775040 Nicotiana tabacum 35-38 33547660-2 2021 Tobacco plants transformed with an MYB regulatory gene from either Solanum chilense (Sc) or S. lycopersicum (Sl) demonstrate that ScANT1 induces a higher level of anthocyanin accumulation in comparison to SlANT1 and that this gene is sufficient to promote increased anthocyanin levels. Anthocyanins 266-277 uncharacterized protein LOC107775040 Nicotiana tabacum 35-38 33547660-6 2021 Our results show that the amino acid changes that differentiate ScANT1 from SlANT1 are the main contributors to the advantage that ScANT1 has over SlANT1 in anthocyanin accumulation per transcript unit. Anthocyanins 157-168 anthocyanin 1 Solanum lycopersicum 76-82 33547660-6 2021 Our results show that the amino acid changes that differentiate ScANT1 from SlANT1 are the main contributors to the advantage that ScANT1 has over SlANT1 in anthocyanin accumulation per transcript unit. Anthocyanins 157-168 anthocyanin 1 Solanum lycopersicum 147-153 33547660-7 2021 We further demonstrated that altering the amino acid composition of SlANT1 could increase anthocyanin accumulation, while reciprocally modifying ScANT1 lowers the anthocyanin level. Anthocyanins 90-101 anthocyanin 1 Solanum lycopersicum 68-74 33547660-8 2021 These results confirm the increased anthocyanin level in tobacco is attributed to the amino acid differences between ScANT1 and SlANT1. Anthocyanins 36-47 anthocyanin 1 Solanum lycopersicum 128-134 33547660-9 2021 We also show that the co-expression of SlJAF13 with SlANT1 in tobacco plants represses the anthocyanin production. Anthocyanins 91-102 anthocyanin 1 Solanum lycopersicum 52-58 33603662-0 2020 Anthocyanin Protects Cardiac Function and Cardiac Fibroblasts From High-Glucose Induced Inflammation and Myocardial Fibrosis by Inhibiting IL-17. Anthocyanins 0-11 interleukin 17A Mus musculus 139-144 33603662-13 2020 Meanwhile, anthocyanin reduced the expression of IL-17 in high-glucose-treated cardiac fibroblasts and exhibited an anti-inflammatory effect. Anthocyanins 11-22 interleukin 17A Mus musculus 49-54 33603662-15 2020 In summary, anthocyanin could protect cardiac function and inhibit IL-17-related inflammation and fibrosis, which indicates its therapeutic potential in the treatment of diabetes mellitus-related complications. Anthocyanins 12-23 interleukin 17A Mus musculus 67-72 32317748-7 2021 Linear trend analysis showed that anthocyanin supplementation has a strong dose-response relationship with CEC (P = 0.002), HDL-C (P = 0.038), and ApoA-I (P = 0.023). Anthocyanins 34-45 apolipoprotein A1 Homo sapiens 147-153 33217069-8 2021 Thus, during the constitutive expression of ZmSRO1e, formation of the complex was compromised, leading to the repression of genes, such as ZmA4 (encoding dihydroflavonol reductase), associated with anthocyanin synthesis. Anthocyanins 198-209 glycosyltransferase Zea mays 139-143 32614624-6 2021 Combination of ACNs:PAs decreased gene expression of AKT1 and eNOS, while protein levels of AKT1 increased. Anthocyanins 15-19 AKT serine/threonine kinase 1 Homo sapiens 53-57 33487363-0 2021 PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) negatively regulates anthocyanin accumulation by inhibiting PAP1 transcription in Arabidopsis seedlings. Anthocyanins 61-72 phytochrome interacting factor 4 Arabidopsis thaliana 0-32 33487363-0 2021 PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) negatively regulates anthocyanin accumulation by inhibiting PAP1 transcription in Arabidopsis seedlings. Anthocyanins 61-72 phytochrome interacting factor 4 Arabidopsis thaliana 34-38 33487363-0 2021 PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) negatively regulates anthocyanin accumulation by inhibiting PAP1 transcription in Arabidopsis seedlings. Anthocyanins 61-72 phosphatidic acid phosphatase 1 Arabidopsis thaliana 100-104 33487363-3 2021 However, the mechanism by which PIF4 participates in the regulation of anthocyanin accumulation remains to be elucidated. Anthocyanins 71-82 phytochrome interacting factor 4 Arabidopsis thaliana 32-36 33487363-4 2021 In this study, we found that anthocyanin accumulation was effectively induced by white light in Arabidopsis Col-0, but such an effect was impaired in the overexpression line PIF4OX. Anthocyanins 29-40 phytochrome interacting factor 4 Arabidopsis thaliana 174-178 33487363-5 2021 Consistently, the transcript level of PAP1 that encodes a key transcript factor involved in regulating anthocyanin biosynthesis was significantly decreased in PIF4OX compared with Col-0. Anthocyanins 103-114 phosphatidic acid phosphatase 1 Arabidopsis thaliana 38-42 33487363-5 2021 Consistently, the transcript level of PAP1 that encodes a key transcript factor involved in regulating anthocyanin biosynthesis was significantly decreased in PIF4OX compared with Col-0. Anthocyanins 103-114 phytochrome interacting factor 4 Arabidopsis thaliana 159-165 33487363-6 2021 Moreover, the expression of PAP1 was markedly lower in pap1-D/PIF4OX than pap1-D, as a result, the phenotype that highly accumulates anthocyanins in leaves of pap1-D caused by PAP1 overexpressing was almost eliminated in pap1-D/PIF4OX. Anthocyanins 133-145 phosphatidic acid phosphatase 1 Arabidopsis thaliana 28-32 33487363-6 2021 Moreover, the expression of PAP1 was markedly lower in pap1-D/PIF4OX than pap1-D, as a result, the phenotype that highly accumulates anthocyanins in leaves of pap1-D caused by PAP1 overexpressing was almost eliminated in pap1-D/PIF4OX. Anthocyanins 133-145 phosphatidic acid phosphatase 1 Arabidopsis thaliana 55-59 33487363-6 2021 Moreover, the expression of PAP1 was markedly lower in pap1-D/PIF4OX than pap1-D, as a result, the phenotype that highly accumulates anthocyanins in leaves of pap1-D caused by PAP1 overexpressing was almost eliminated in pap1-D/PIF4OX. Anthocyanins 133-145 phytochrome interacting factor 4 Arabidopsis thaliana 62-68 33487363-6 2021 Moreover, the expression of PAP1 was markedly lower in pap1-D/PIF4OX than pap1-D, as a result, the phenotype that highly accumulates anthocyanins in leaves of pap1-D caused by PAP1 overexpressing was almost eliminated in pap1-D/PIF4OX. Anthocyanins 133-145 phosphatidic acid phosphatase 1 Arabidopsis thaliana 74-78 33487363-6 2021 Moreover, the expression of PAP1 was markedly lower in pap1-D/PIF4OX than pap1-D, as a result, the phenotype that highly accumulates anthocyanins in leaves of pap1-D caused by PAP1 overexpressing was almost eliminated in pap1-D/PIF4OX. Anthocyanins 133-145 phosphatidic acid phosphatase 1 Arabidopsis thaliana 74-78 33487363-6 2021 Moreover, the expression of PAP1 was markedly lower in pap1-D/PIF4OX than pap1-D, as a result, the phenotype that highly accumulates anthocyanins in leaves of pap1-D caused by PAP1 overexpressing was almost eliminated in pap1-D/PIF4OX. Anthocyanins 133-145 phosphatidic acid phosphatase 1 Arabidopsis thaliana 176-180 33487363-6 2021 Moreover, the expression of PAP1 was markedly lower in pap1-D/PIF4OX than pap1-D, as a result, the phenotype that highly accumulates anthocyanins in leaves of pap1-D caused by PAP1 overexpressing was almost eliminated in pap1-D/PIF4OX. Anthocyanins 133-145 phosphatidic acid phosphatase 1 Arabidopsis thaliana 74-78 33487363-6 2021 Moreover, the expression of PAP1 was markedly lower in pap1-D/PIF4OX than pap1-D, as a result, the phenotype that highly accumulates anthocyanins in leaves of pap1-D caused by PAP1 overexpressing was almost eliminated in pap1-D/PIF4OX. Anthocyanins 133-145 phytochrome interacting factor 4 Arabidopsis thaliana 228-234 33487363-9 2021 Subsequently, when the seedlings shifted from darkness to light and grew under constant red light and short-day photoperiod, it was found that the PAP1 transcription level and anthocyanin content in pif4-2/pap1-D were significantly higher than pap1-D, implying that PIF4 mutation can strengthen PAP1"s effect on anthocyanin biosynthesis under these conditions. Anthocyanins 176-187 phytochrome interacting factor 4 Arabidopsis thaliana 199-203 33487363-9 2021 Subsequently, when the seedlings shifted from darkness to light and grew under constant red light and short-day photoperiod, it was found that the PAP1 transcription level and anthocyanin content in pif4-2/pap1-D were significantly higher than pap1-D, implying that PIF4 mutation can strengthen PAP1"s effect on anthocyanin biosynthesis under these conditions. Anthocyanins 176-187 phosphatidic acid phosphatase 1 Arabidopsis thaliana 206-210 33487363-9 2021 Subsequently, when the seedlings shifted from darkness to light and grew under constant red light and short-day photoperiod, it was found that the PAP1 transcription level and anthocyanin content in pif4-2/pap1-D were significantly higher than pap1-D, implying that PIF4 mutation can strengthen PAP1"s effect on anthocyanin biosynthesis under these conditions. Anthocyanins 312-323 phosphatidic acid phosphatase 1 Arabidopsis thaliana 147-151 33487363-10 2021 Taken together, the results indicate that PIF4 negatively regulates anthocyanin accumulation in Arabidopsis through transcriptional suppression of PAP1 by directly binding to the G-box motif of the promoter. Anthocyanins 68-79 phytochrome interacting factor 4 Arabidopsis thaliana 42-46 33487363-10 2021 Taken together, the results indicate that PIF4 negatively regulates anthocyanin accumulation in Arabidopsis through transcriptional suppression of PAP1 by directly binding to the G-box motif of the promoter. Anthocyanins 68-79 phosphatidic acid phosphatase 1 Arabidopsis thaliana 147-151 32768906-2 2021 WPI was found to enhance both the stability and antioxidant activity of ANs during processing and simulated in vitro digestion, especially at a concentration of 0.15 mg mL-1. Anthocyanins 72-75 L1 cell adhesion molecule Mus musculus 169-173 33491773-3 2021 Therefore, to further expand the medicinal value of purple corncob, the purification and content of the anthocyanins of purple corncob were carried out, and the effect and mechanism of purified purple corncob anthocyanins (PPCCA) on CCl4 -induced chronic liver injury in mice was investigated. Anthocyanins 209-221 chemokine (C-C motif) ligand 4 Mus musculus 233-237 33479339-0 2021 Chondroprotective effects of purple corn anthocyanins on advanced glycation end products induction through suppression of NF-kappaB and MAPK signaling. Anthocyanins 41-53 nuclear factor kappa B subunit 1 Homo sapiens 122-131 33479339-6 2021 Investigation of the molecular mechanisms in human articular chondrocytes showed the anti-inflammatory effect of purple corn anthocyanins and the metabolite, protocatechuic acid (PCA) on AGEs induced human articular chondrocytes via inactivation of the NFkappab and MAPK signaling pathways. Anthocyanins 125-137 nuclear factor kappa B subunit 1 Homo sapiens 253-261 33564327-1 2021 Light- and pH-responsive nano-assemblies with switchable size and structure are formed by the association of a photoacid, anthocyanidin, and a linear polyelectrolyte in aqueous solution. Anthocyanins 122-135 phenylalanine hydroxylase Homo sapiens 11-13 33537042-6 2020 Arabidopsis PpHY5/hy5 transgenic lines accumulated higher amounts of anthocyanin under UV supplementation (compared with weak white light only), especially when UVA and UVB were applied together. Anthocyanins 69-80 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 18-21 33419064-3 2021 We found that cyanidin-3-glucoside (C3G), the anthocyanin with two hydroxyl groups on the B-ring, and cyanidin significantly reduce the protein level of CLDN2 in A549 cells. Anthocyanins 46-57 claudin 2 Homo sapiens 153-158 33404922-10 2021 Moreover, the loss of anthocyanin was attributed to decreased expression of dihydroflavonol reductase (DFR) and anthocyanidin synthase (ANS) genes in transgenic A. thaliana that expressed DoFLS1. Anthocyanins 22-33 dihydroflavonol 4-reductase Arabidopsis thaliana 76-101 33404922-10 2021 Moreover, the loss of anthocyanin was attributed to decreased expression of dihydroflavonol reductase (DFR) and anthocyanidin synthase (ANS) genes in transgenic A. thaliana that expressed DoFLS1. Anthocyanins 22-33 dihydroflavonol 4-reductase Arabidopsis thaliana 103-106 33404922-11 2021 DoFLS1 also complemented the deficiency in flavonol of the A. thaliana fls1-3 mutant, which had reduced anthocyanin but increased flavonol content relative to the fls1-3 mutant. Anthocyanins 104-115 flavonol synthase 1 Arabidopsis thaliana 71-77 33100126-1 2021 The Arabidopsis transcription factor Myeloblastosis protein 75 (MYB75, AT1G56650) is a well-established transcriptional activator of genes required for anthocyanin and flavonoid production, and a repressor of lignin and other secondary cell wall biosynthesis genes. Anthocyanins 152-163 production of anthocyanin pigment 1 Arabidopsis thaliana 37-62 33100126-1 2021 The Arabidopsis transcription factor Myeloblastosis protein 75 (MYB75, AT1G56650) is a well-established transcriptional activator of genes required for anthocyanin and flavonoid production, and a repressor of lignin and other secondary cell wall biosynthesis genes. Anthocyanins 152-163 production of anthocyanin pigment 1 Arabidopsis thaliana 64-69 32702589-0 2021 Effects of alpha-casein and beta-casein on the stability, antioxidant activity and bioaccessibility of blueberry anthocyanins with an in vitro simulated digestion. Anthocyanins 113-125 casein beta Homo sapiens 28-39 32478572-0 2021 Role of Blueberry Anthocyanin Extract in the Expression of SIRT1 and NF-kappaB in Rat Lens Epithelial Cells in Experimentally Induced DM. Anthocyanins 18-29 sirtuin 1 Rattus norvegicus 59-64 32702589-3 2021 The current study aimed to investigate the alteration in the stability, antioxidant capacity and bioaccessibility of blueberry anthocyanins with the addition of alpha-casein and beta-casein in a simulated digestion system using pH differential method, HPLC-MS analysis, peroxyl scavenging capacity (PSC) assay, cellular antioxidant activity (CAA) and penetration test. Anthocyanins 127-139 casein beta Homo sapiens 178-189 32702589-4 2021 The results showed that both alpha-casein and beta-casein could increase the stability of blueberry anthocyanins during intestinal digestion and protect their antioxidant capacity. Anthocyanins 100-112 casein beta Homo sapiens 46-57 32702589-5 2021 Moreover, the addition of alpha-casein or beta-casein would enhance the bioaccessibility of blueberry anthocyanins. Anthocyanins 102-114 casein beta Homo sapiens 42-53 32702589-6 2021 In conclusion, our study highlights that the interaction between alpha-casein or beta-casein with blueberry anthocyanins can protect the compounds against influences associated with the simulated digestion. Anthocyanins 108-120 casein beta Homo sapiens 81-92 32326848-0 2021 Inhibitory effects of bioaccessible anthocyanins and procyanidins from apple, red grape, cinnamon on alpha-amylase, alpha-glucosidase and lipase. Anthocyanins 36-48 sucrase-isomaltase Homo sapiens 116-133 33189294-0 2021 Effect of anthocyanin-absorbed whey protein microgels on physicochemical and textural properties of reduced-fat Cheddar cheese. Anthocyanins 10-21 solute carrier family 19 member 1 Homo sapiens 100-126 33189294-8 2021 The WPM and WPM (Ant) showed a high potential as fat substitutes and anthocyanin carriers to effectively improve the acceptance of reduced-fat foods. Anthocyanins 69-80 solute carrier family 25 member 6 Homo sapiens 17-20 33100202-9 2021 Some natural/plant derived compounds including fatty acids, sesquiterpenes, phenolic compounds, anthocyanins, isoquinoline and indole alkaloids were also reported as potent FFAR1 agonists. Anthocyanins 96-108 free fatty acid receptor 1 Homo sapiens 173-178 33272791-4 2021 In the present study, in order to further understand the regulatory mechanism underlying the anthocyanin biosynthesis, a bHLH gene NnTT8 was characterized to be phylogenetically close to AtTT8 and the bHLH proteins from other plant species that have been indicated to be involved in the positive regulation of anthocyanin biosynthesis. Anthocyanins 93-104 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 187-192 33272791-5 2021 Complementation analysis in Arabidopsis tt8 mutant showed that NnTT8 could function similarly to AtTT8 in regulating anthocyanin and proanthocyanin biosynthesis. Anthocyanins 117-128 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 40-43 33318175-4 2020 Loss of AtINO80 inhibited hypocotyl cell elongation and caused anthocyanin accumulation. Anthocyanins 63-74 DNA helicase INO80-like protein Arabidopsis thaliana 8-15 33353018-5 2020 Anthocyanins prevented deficits in working memory induced by Abeta or a long-term grain mono-diet; they partially reversed episodic memory alterations. Anthocyanins 0-12 amyloid beta (A4) precursor protein Mus musculus 61-66 33353018-8 2020 The anthocyanin-rich diet reduced alpha-synuclein accumulation and modulated microglial response in the brain of the transgenic mice including the elevated expression of arginase1 that marks M2 microglia. Anthocyanins 4-15 synuclein, alpha Mus musculus 34-49 33353018-8 2020 The anthocyanin-rich diet reduced alpha-synuclein accumulation and modulated microglial response in the brain of the transgenic mice including the elevated expression of arginase1 that marks M2 microglia. Anthocyanins 4-15 arginase, liver Mus musculus 170-179 33087416-5 2020 ELONGATED HYPOCOTYL5 (HY5) binds to the DEWAX promoter elements and represses its expression to promote the anthocyanin biosynthesis. Anthocyanins 108-119 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 10-20 32698067-1 2020 Sodium alginates with different mannuronate to guluronate units ratio ALG1 and ALG2 were employed in the formation of insoluble complexes with anthocyanins (ATC) extracted from Vaccinium myrtilus by exploiting the electrostatic interaction between carboxylate groups of sodium alginate (ALG) and flavylium cations of ATC. Anthocyanins 143-155 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase Homo sapiens 70-74 32698067-1 2020 Sodium alginates with different mannuronate to guluronate units ratio ALG1 and ALG2 were employed in the formation of insoluble complexes with anthocyanins (ATC) extracted from Vaccinium myrtilus by exploiting the electrostatic interaction between carboxylate groups of sodium alginate (ALG) and flavylium cations of ATC. Anthocyanins 143-155 ALG2 alpha-1,3/1,6-mannosyltransferase Homo sapiens 79-83 32698067-1 2020 Sodium alginates with different mannuronate to guluronate units ratio ALG1 and ALG2 were employed in the formation of insoluble complexes with anthocyanins (ATC) extracted from Vaccinium myrtilus by exploiting the electrostatic interaction between carboxylate groups of sodium alginate (ALG) and flavylium cations of ATC. Anthocyanins 296-305 ALG2 alpha-1,3/1,6-mannosyltransferase Homo sapiens 79-83 33317160-7 2020 Consistent improvements from anthocyanin intake were found in glycemic, gastric inhibitory peptide (GIP), interleukin-6 (IL-6), and oxygen radical absorbance capacity (ORAC) responses. Anthocyanins 29-40 gastric inhibitory polypeptide Homo sapiens 72-98 33317160-7 2020 Consistent improvements from anthocyanin intake were found in glycemic, gastric inhibitory peptide (GIP), interleukin-6 (IL-6), and oxygen radical absorbance capacity (ORAC) responses. Anthocyanins 29-40 gastric inhibitory polypeptide Homo sapiens 100-103 33317160-7 2020 Consistent improvements from anthocyanin intake were found in glycemic, gastric inhibitory peptide (GIP), interleukin-6 (IL-6), and oxygen radical absorbance capacity (ORAC) responses. Anthocyanins 29-40 interleukin 6 Homo sapiens 106-119 33317160-7 2020 Consistent improvements from anthocyanin intake were found in glycemic, gastric inhibitory peptide (GIP), interleukin-6 (IL-6), and oxygen radical absorbance capacity (ORAC) responses. Anthocyanins 29-40 interleukin 6 Homo sapiens 121-125 33087416-5 2020 ELONGATED HYPOCOTYL5 (HY5) binds to the DEWAX promoter elements and represses its expression to promote the anthocyanin biosynthesis. Anthocyanins 108-119 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 22-25 33087416-6 2020 The HY5-DEWAX regulatory network regulates anthocyanin content in Arabidopsis thaliana and influences the survivability of plants under UV-B irradiation stress. Anthocyanins 43-54 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 4-7 33198624-11 2020 The two endogenous bHLH genes NtAn1a and NtAn1b were also upregulated and may work in combination with PsMYB57 in regulating anthocyanin structural genes. Anthocyanins 125-136 basic helix-loop-helix protein A-like Nicotiana tabacum 30-36 33198624-11 2020 The two endogenous bHLH genes NtAn1a and NtAn1b were also upregulated and may work in combination with PsMYB57 in regulating anthocyanin structural genes. Anthocyanins 125-136 basic helix-loop-helix protein A-like Nicotiana tabacum 41-47 33204882-6 2020 The anthocyanin-rich fraction of all extracts inhibited pancreatic lipase and cholesterol esterase with the IC50 values of 90.6-181.7 mug/mL and 288.7-455.0 mug/mL, respectively. Anthocyanins 4-15 carboxyl ester lipase Homo sapiens 78-98 33152049-12 2020 The present results also showed that the synthesis and accumulation of anthocyanins in jujube fruit were positively correlated with sugar content and related enzyme activities, especially Phenylalanine Ammonia-lyase (PAL) activity. Anthocyanins 71-83 phenylalanine ammonia-lyase Ziziphus jujuba 188-215 33152049-12 2020 The present results also showed that the synthesis and accumulation of anthocyanins in jujube fruit were positively correlated with sugar content and related enzyme activities, especially Phenylalanine Ammonia-lyase (PAL) activity. Anthocyanins 71-83 phenylalanine ammonia-lyase Ziziphus jujuba 217-220 32905943-2 2020 Recently, we demonstrated that anthocyanidins in berries induce the catalytic activity of SIRT6. Anthocyanins 31-45 sirtuin 6 Homo sapiens 90-95 33274583-6 2020 Anthocyanins reversed d-gal-mediated inhibition of endothelial nitric oxide synthase (eNOS) serine phosphorylation and SIRT1 expression, recovering NO level in endothelial cells. Anthocyanins 0-12 nitric oxide synthase 3 Rattus norvegicus 51-84 33274583-6 2020 Anthocyanins reversed d-gal-mediated inhibition of endothelial nitric oxide synthase (eNOS) serine phosphorylation and SIRT1 expression, recovering NO level in endothelial cells. Anthocyanins 0-12 nitric oxide synthase 3 Rattus norvegicus 86-90 33274583-6 2020 Anthocyanins reversed d-gal-mediated inhibition of endothelial nitric oxide synthase (eNOS) serine phosphorylation and SIRT1 expression, recovering NO level in endothelial cells. Anthocyanins 0-12 sirtuin 1 Rattus norvegicus 119-124 33274583-7 2020 Also, SIRT1-mediated eNOS deacetylation was shown to be involved in anthocyanin-enhanced eNOS activity. Anthocyanins 68-79 sirtuin 1 Rattus norvegicus 6-11 33274583-7 2020 Also, SIRT1-mediated eNOS deacetylation was shown to be involved in anthocyanin-enhanced eNOS activity. Anthocyanins 68-79 nitric oxide synthase 3 Rattus norvegicus 21-25 33274583-7 2020 Also, SIRT1-mediated eNOS deacetylation was shown to be involved in anthocyanin-enhanced eNOS activity. Anthocyanins 68-79 nitric oxide synthase 3 Rattus norvegicus 89-93 33274583-13 2020 These findings indicate that anthocyanins protect against endothelial senescence through enhanced NO bioavailability by regulating ROS formation and reducing eNOS uncoupling. Anthocyanins 29-41 nitric oxide synthase 3 Rattus norvegicus 158-162 33016000-0 2020 Anthocyanins from Aronia melanocarpa Elliot induce apoptosis in Caco-2 cells through Wnt/beta-catenin signaling pathway. Anthocyanins 0-12 catenin beta 1 Homo sapiens 89-101 33016000-3 2020 The experimental results showed that the binding energy of anthocyanins on beta-Catenin was in the range of -5.92 to 4.95 kcal/mol, with good low energy parameters and binding positions. Anthocyanins 59-71 catenin beta 1 Homo sapiens 75-87