PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11846996-0	2001	Effect of dimethoate on the function and expression of nicotinic acetylcholine receptor in primary skeletal muscle cell culture.	Dimethoate	10-20	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	55-87
12020020-9	2002	The decrease in susceptibility in the O. pratensis strains exposed to bifenthrin, lambda-cyhalothrin, and dimethoate was associated with a 4.7-, 3.0-, and 3.6-fold increase in general esterase activity, respectively.	Dimethoate	106-116	acetylcholinesterase-like	Tetranychus urticae	184-192
11985885-2	2002	The results showed that the activity of AChE was significantly inhibited in a dose and time-dependent manner when cells were exposed to dimethoate for 2 h, but the expression of heat-shock protein (HSP70) in muscle cells was significantly increased in a time-dependent manner following dimethoate exposure.	Dimethoate	286-296	heat shock protein family A (Hsp70) member 4	Homo sapiens	178-203
11846996-2	2001	The results showed that the expression of nAChR on the muscle cell membrane was significantly increased after cells were exposed to dimethoate (130 microM).	Dimethoate	132-142	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	42-47
11846996-3	2001	AChR function measured by carbachol-induced (22)Na+ influx demonstrated that dimethoate may inhibit the nAChR function either by binding to a noncompetitive site and changing the conformational state of nAChR or by blocking the nAChR channel directly.	Dimethoate	77-87	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	104-109
11846996-3	2001	AChR function measured by carbachol-induced (22)Na+ influx demonstrated that dimethoate may inhibit the nAChR function either by binding to a noncompetitive site and changing the conformational state of nAChR or by blocking the nAChR channel directly.	Dimethoate	77-87	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	203-208
11846996-3	2001	AChR function measured by carbachol-induced (22)Na+ influx demonstrated that dimethoate may inhibit the nAChR function either by binding to a noncompetitive site and changing the conformational state of nAChR or by blocking the nAChR channel directly.	Dimethoate	77-87	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	203-208
11846996-4	2001	This study also demonstrated that dimethoate could rapidly induce the expression of c-fos, with a maximal effect at about 40 min, and c-fos might act as a transcriptional factor in regulating the expression of nAChR in the primary skeletal muscle cell culture following organophosphate exposure.	Dimethoate	34-44	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-89
11054639-0	2000	Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene.	Dimethoate	0-10	steroidogenic acute regulatory protein	Mus musculus	71-101
11834209-5	2001	The increase in the activities of superoxide dismutase (SOD) and catalase (CAT) and total-SH content in erythrocytes from dimethoate and/or malathion treated rats as compared to control appears to be a response towards increased oxidative stress.	Dimethoate	122-132	catalase	Rattus norvegicus	75-78
11054639-0	2000	Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene.	Dimethoate	0-10	steroidogenic acute regulatory protein	Mus musculus	103-107
11054639-6	2000	Instead, our results suggest that Dimethoate inhibited steroidogenesis primarily by blocking transcription of the steroidogenic acute regulatory (StAR) gene.	Dimethoate	34-44	steroidogenic acute regulatory protein	Mus musculus	114-144
11054639-6	2000	Instead, our results suggest that Dimethoate inhibited steroidogenesis primarily by blocking transcription of the steroidogenic acute regulatory (StAR) gene.	Dimethoate	34-44	steroidogenic acute regulatory protein	Mus musculus	146-150
10350597-4	1999	The result of Trad-MCN test on Dimethoate fumes was not significantly different between the control and treated groups.	Dimethoate	31-41	RAD51 paralog D	Homo sapiens	14-18
10964798-4	2000	We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein.	Dimethoate	101-111	steroidogenic acute regulatory protein	Mus musculus	193-223
10964798-4	2000	We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein.	Dimethoate	101-111	steroidogenic acute regulatory protein	Mus musculus	225-229
9588346-8	1998	Concentrations of insulin in serum were markedly increased in ewes given dimethoate, lindane, trifluralin, triallate, and pentachlorophenol, and concentrations of estradiol were also significantly increased in ewes given lindane and trifluralin.	Dimethoate	73-83	insulin	Homo sapiens	18-25
11939005-0	1999	[Effect of dimethoate on the expression of c-fos gene in skeletal muscle].	Dimethoate	11-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	43-48
11939005-2	1999	The result showed that c-fos mRNA and protein were significantly increased in skeletal muscle of rat after dosing with dimethoate.	Dimethoate	119-129	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-28
34624818-9	2022	The IRu(III)/IFe(III) value increased with the increase of dimethoate concentration in the linear range of 0.01-300 ng mL-1, and the detection limit was 6.3 pg mL-1.	Dimethoate	59-69	L1 cell adhesion molecule	Mus musculus	119-123
8687995-8	1996	Exposure to dimethoate caused a dose-dependent decrease in ChE activity in the brain and in serum.	Dimethoate	12-22	butyrylcholinesterase	Mus musculus	59-62
8687995-10	1996	Recovery of ChE activity lagged behind that of behavioral impairment and started 3-6 h after dimethoate administration.	Dimethoate	93-103	butyrylcholinesterase	Mus musculus	12-15
23902326-0	1996	The relationships between brain, serum, and whole blood ChE activity in the wood mouse (Apodemus sylvaticus) and the common shrew (Sorex araneus) after acute sublethal exposure to dimethoate.	Dimethoate	180-190	butyrylcholinesterase	Mus musculus	56-59
23902326-1	1996	Abstract Inhibition of cholinesterase (ChE) activity produced by a single acute intraperitoneal administration of dimethoate was studied in the wood mouse, Apodemus sylvaticus, and the common shrew, Sorex araneus, under laboratory conditions.	Dimethoate	114-124	butyrylcholinesterase	Mus musculus	23-37
23902326-1	1996	Abstract Inhibition of cholinesterase (ChE) activity produced by a single acute intraperitoneal administration of dimethoate was studied in the wood mouse, Apodemus sylvaticus, and the common shrew, Sorex araneus, under laboratory conditions.	Dimethoate	114-124	butyrylcholinesterase	Mus musculus	39-42
23902326-6	1996	Exposure to dimethoate caused a dose-dependent reduction in ChE activity and there was a significant recovery in activity with increasing time after administration.	Dimethoate	12-22	butyrylcholinesterase	Mus musculus	60-63
1459616-4	1992	A significant increase in the rate of release of beta-glucuronidase was found in the liver and kidney of higher concentration of dimethoate treated rats compared to controls.	Dimethoate	129-139	glucuronidase, beta	Rattus norvegicus	49-67
1816087-0	1991	Effect of dimethoate on hepatic cytochrome P-450 and glutathione S-transferase activity in pigeon and rat.	Dimethoate	10-20	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	32-48
1816087-0	1991	Effect of dimethoate on hepatic cytochrome P-450 and glutathione S-transferase activity in pigeon and rat.	Dimethoate	10-20	hematopoietic prostaglandin D synthase	Rattus norvegicus	53-78
1816087-1	1991	Effect of acute exposure (24 hr) to different oral doses of dimethoate on hepatic microsomal cytochrome P-450 (Cyt.	Dimethoate	60-70	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	93-109
1816087-7	1991	P-450 decrease and a differed response of GST activity against dimethoate exposure in pigeon and rat may be one of the possible causes for relatively higher toxicity of dimethoate in birds.	Dimethoate	63-73	hematopoietic prostaglandin D synthase	Rattus norvegicus	42-45
1816087-7	1991	P-450 decrease and a differed response of GST activity against dimethoate exposure in pigeon and rat may be one of the possible causes for relatively higher toxicity of dimethoate in birds.	Dimethoate	169-179	hematopoietic prostaglandin D synthase	Rattus norvegicus	42-45
22844700-1	2012	This study presents the results of research concerning the effect of single and combined application of pyrantel tartrate and dimethoate on selected antioxidative enzymes: catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx), in rat erythrocytes.	Dimethoate	126-136	catalase	Rattus norvegicus	172-180
22844700-1	2012	This study presents the results of research concerning the effect of single and combined application of pyrantel tartrate and dimethoate on selected antioxidative enzymes: catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx), in rat erythrocytes.	Dimethoate	126-136	catalase	Rattus norvegicus	182-185
22844700-5	2012	Subchronic exposure of rats to dimethoate caused a significant increase in the activity of CAT, SOD and GPx in erythrocytes, indicating the existence of strong oxidative stress.	Dimethoate	31-41	catalase	Rattus norvegicus	91-94
9490325-8	1998	Serum and erythrocyte cholinesterase activities in workers formulating dimethoate products were not significantly different before and after exposure.	Dimethoate	71-81	butyrylcholinesterase	Homo sapiens	22-36
8975827-2	1996	Male mice were radio-tagged at night and followed during 2-3-d periods, before and after an intraperitoneal injection of 50 mg/kg dimethoate which previous laboratory studies had demonstrated causes a maximum depression in brain acetylcholinesterase (AChE) activity of 75% relative to non-exposed mice.	Dimethoate	130-140	acetylcholinesterase	Mus musculus	229-249
8975827-2	1996	Male mice were radio-tagged at night and followed during 2-3-d periods, before and after an intraperitoneal injection of 50 mg/kg dimethoate which previous laboratory studies had demonstrated causes a maximum depression in brain acetylcholinesterase (AChE) activity of 75% relative to non-exposed mice.	Dimethoate	130-140	acetylcholinesterase	Mus musculus	251-255
1459616-3	1992	The activity of beta-glucuronidase, beta-N-acetylglucosaminidase, cathepsin D was found to increase in serum and tissues in higher concentration (2.25 mg/100 g body weight) of dimethoate treated rats.	Dimethoate	176-186	glucuronidase, beta	Rattus norvegicus	16-34
1459616-3	1992	The activity of beta-glucuronidase, beta-N-acetylglucosaminidase, cathepsin D was found to increase in serum and tissues in higher concentration (2.25 mg/100 g body weight) of dimethoate treated rats.	Dimethoate	176-186	cathepsin D	Rattus norvegicus	66-77
34624818-9	2022	The IRu(III)/IFe(III) value increased with the increase of dimethoate concentration in the linear range of 0.01-300 ng mL-1, and the detection limit was 6.3 pg mL-1.	Dimethoate	59-69	L1 cell adhesion molecule	Mus musculus	160-164
33705722-2	2021	A simple, accurate, and sensitive gas chromatography-ion trap mass spectrometry-based method for the quantification of 12 anticholinesterase pesticides (monocrotophos, dimethoate, dichlorvos, azinphos-methyl, carbofuran, chlorpyrifos, dialifos, diazinon, malathion, parathion, methidathion, and terbufos) in serum was developed, and its utility in patients with alleged pesticides poisoning was assessed.	Dimethoate	168-178	gastrin	Homo sapiens	34-37
34395382-4	2021	Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl.	Dimethoate	289-299	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-126
34395382-4	2021	Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl.	Dimethoate	289-299	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
2588727-0	1989	[Behavior of serum cholinesterase and acetylcholinesterase activity in acute dimethoate poisoning].	Dimethoate	77-87	butyrylcholinesterase	Homo sapiens	19-33
2588727-0	1989	[Behavior of serum cholinesterase and acetylcholinesterase activity in acute dimethoate poisoning].	Dimethoate	77-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-58
2588727-1	1989	With a patient who in suicidal intention had orally taken a larger quantity of Bi 58 EC (dimethoate) especially the behaviour of the serum cholinesterase activity and the whole blood acetylcholinesterase activity was observed over a period of 38 days and it was compared with the clinical appearance.	Dimethoate	79-87	butyrylcholinesterase	Homo sapiens	139-153
2588727-1	1989	With a patient who in suicidal intention had orally taken a larger quantity of Bi 58 EC (dimethoate) especially the behaviour of the serum cholinesterase activity and the whole blood acetylcholinesterase activity was observed over a period of 38 days and it was compared with the clinical appearance.	Dimethoate	79-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	183-203
2588727-1	1989	With a patient who in suicidal intention had orally taken a larger quantity of Bi 58 EC (dimethoate) especially the behaviour of the serum cholinesterase activity and the whole blood acetylcholinesterase activity was observed over a period of 38 days and it was compared with the clinical appearance.	Dimethoate	89-99	butyrylcholinesterase	Homo sapiens	139-153
2588727-1	1989	With a patient who in suicidal intention had orally taken a larger quantity of Bi 58 EC (dimethoate) especially the behaviour of the serum cholinesterase activity and the whole blood acetylcholinesterase activity was observed over a period of 38 days and it was compared with the clinical appearance.	Dimethoate	89-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	183-203
719292-0	1978	Motor output to flight muscles and inhibition of acetylcholinesterase after injection of dimethoate into locusts [proceedings].	Dimethoate	89-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-69
34199875-2	2021	In Italy, the fruit fly infestation is traditionally countered by spraying chemical insecticides (e.g., dimethoate), but due to the recent ban of dimethoate by the Reg EU2019/1090 and the increasing awareness of consumers of food sustainability, the interest in developing chemical-free alternatives to pesticides, such as the use of particle-films, is rising.	Dimethoate	146-156	Proteasome regulator gamma	Drosophila melanogaster	164-167
2973491-4	1988	AChE activity was increased (P less than 0.01) after 1 month of treatment with the two doses of dimethoate and deltamethrin; thereafter, AChE activity showed 40% inhibition of the control level.	Dimethoate	96-106	ACE-1	Oryctolagus cuniculus	0-4
2973491-4	1988	AChE activity was increased (P less than 0.01) after 1 month of treatment with the two doses of dimethoate and deltamethrin; thereafter, AChE activity showed 40% inhibition of the control level.	Dimethoate	96-106	ACE-1	Oryctolagus cuniculus	137-141
3775801-2	1986	CS2 pretreatment potentiated the anticholinesterase action of parathion and EPN, but suppressed that of dimethoate and diazinon.	Dimethoate	104-114	calsyntenin 2	Mus musculus	0-3
32408495-5	2020	Further, the trace analysis of dimethoate in spiked olive oil samples was validated and successfully implemented using smart-MIPs as sorbents in the sample preparation step, with high recoveries (83.5 +- 0.3%) and low detection limit (0.03microg mL-1).	Dimethoate	31-41	L1 cell adhesion molecule	Mus musculus	246-250
33916863-2	2021	The principle of the sensing platform is based on the inhibition of dimethoate (DMT), a typical OP that specifically inhibits acetylcholinesterase (AChE) activity.	Dimethoate	68-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-146
33916863-2	2021	The principle of the sensing platform is based on the inhibition of dimethoate (DMT), a typical OP that specifically inhibits acetylcholinesterase (AChE) activity.	Dimethoate	68-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	148-152
33916863-2	2021	The principle of the sensing platform is based on the inhibition of dimethoate (DMT), a typical OP that specifically inhibits acetylcholinesterase (AChE) activity.	Dimethoate	80-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-146
33916863-2	2021	The principle of the sensing platform is based on the inhibition of dimethoate (DMT), a typical OP that specifically inhibits acetylcholinesterase (AChE) activity.	Dimethoate	80-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	148-152
33916863-5	2021	The total amount of AChE was quantified, whose activity inhibition was highly linear with respect to DMT concentration.	Dimethoate	101-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
32521445-1	2020	In this article, a modified paper separation channel SERS substrate was fabricated by a pen writing method for the simultaneous separation and detection of thiuram and dimethoate.	Dimethoate	168-178	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	53-57
31606569-6	2020	Dimethoate did not influence Leydig cell number but reduced Leydig cell size and down-regulated Star, Cyp11a1, and Hsd3b1 in Leydig cells as well as their protein expression.	Dimethoate	0-10	steroidogenic acute regulatory protein	Rattus norvegicus	96-100
31606569-6	2020	Dimethoate did not influence Leydig cell number but reduced Leydig cell size and down-regulated Star, Cyp11a1, and Hsd3b1 in Leydig cells as well as their protein expression.	Dimethoate	0-10	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	102-109
31606569-6	2020	Dimethoate did not influence Leydig cell number but reduced Leydig cell size and down-regulated Star, Cyp11a1, and Hsd3b1 in Leydig cells as well as their protein expression.	Dimethoate	0-10	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	115-121
31606569-10	2020	Further study demonstrated that dimethoate also down-regulated the expression of Star, Cyp11a1, and Hsd3b1 at 5 or 50 muM in vitro.	Dimethoate	32-42	steroidogenic acute regulatory protein	Rattus norvegicus	81-85
31606569-10	2020	Further study demonstrated that dimethoate also down-regulated the expression of Star, Cyp11a1, and Hsd3b1 at 5 or 50 muM in vitro.	Dimethoate	32-42	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	87-94
31606569-10	2020	Further study demonstrated that dimethoate also down-regulated the expression of Star, Cyp11a1, and Hsd3b1 at 5 or 50 muM in vitro.	Dimethoate	32-42	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	100-106
31606569-12	2020	In conclusion, dimethoate targets Star, Cyp11a1, and Hsd3b1 transcription, thus blocking Leydig cell differentiation during puberty.	Dimethoate	15-25	steroidogenic acute regulatory protein	Rattus norvegicus	34-38
31606569-12	2020	In conclusion, dimethoate targets Star, Cyp11a1, and Hsd3b1 transcription, thus blocking Leydig cell differentiation during puberty.	Dimethoate	15-25	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	40-47
31606569-12	2020	In conclusion, dimethoate targets Star, Cyp11a1, and Hsd3b1 transcription, thus blocking Leydig cell differentiation during puberty.	Dimethoate	15-25	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	53-59
30340169-5	2019	In addition, expression of vitellogenin protein and activity of acetylcholinesterase were assessed upon dimethoate exposure to assess physiological effects.	Dimethoate	104-114	vitellogenin	Apis mellifera	27-39
30678826-9	2019	Interestingly, several metabolites including the 4-hydroxyl form of CPA (4-OH-CPA) and phosphamide mustard were detected in the CYP2B6, CYP2C19, and CYP3A4 expression systems, but not in the CYP2C9 and CYP2D6 system.	Dimethoate	87-98	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	128-134
30678826-9	2019	Interestingly, several metabolites including the 4-hydroxyl form of CPA (4-OH-CPA) and phosphamide mustard were detected in the CYP2B6, CYP2C19, and CYP3A4 expression systems, but not in the CYP2C9 and CYP2D6 system.	Dimethoate	87-98	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	136-143
30678826-9	2019	Interestingly, several metabolites including the 4-hydroxyl form of CPA (4-OH-CPA) and phosphamide mustard were detected in the CYP2B6, CYP2C19, and CYP3A4 expression systems, but not in the CYP2C9 and CYP2D6 system.	Dimethoate	87-98	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	149-155
30678826-9	2019	Interestingly, several metabolites including the 4-hydroxyl form of CPA (4-OH-CPA) and phosphamide mustard were detected in the CYP2B6, CYP2C19, and CYP3A4 expression systems, but not in the CYP2C9 and CYP2D6 system.	Dimethoate	87-98	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	191-197
30678826-9	2019	Interestingly, several metabolites including the 4-hydroxyl form of CPA (4-OH-CPA) and phosphamide mustard were detected in the CYP2B6, CYP2C19, and CYP3A4 expression systems, but not in the CYP2C9 and CYP2D6 system.	Dimethoate	87-98	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	202-208
30678826-13	2019	Additionally, CPA metabolites like 4-OH-CPA and phosphamide mustard produced by human CYP2B6, CYP2C9, CYP2C19, and CYP3A4 are suggested to be major determinants of micronucleus induction by CPA.	Dimethoate	48-59	carboxypeptidase A1	Homo sapiens	14-17
30678826-13	2019	Additionally, CPA metabolites like 4-OH-CPA and phosphamide mustard produced by human CYP2B6, CYP2C9, CYP2C19, and CYP3A4 are suggested to be major determinants of micronucleus induction by CPA.	Dimethoate	48-59	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	86-92
30678826-13	2019	Additionally, CPA metabolites like 4-OH-CPA and phosphamide mustard produced by human CYP2B6, CYP2C9, CYP2C19, and CYP3A4 are suggested to be major determinants of micronucleus induction by CPA.	Dimethoate	48-59	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	94-100
30678826-13	2019	Additionally, CPA metabolites like 4-OH-CPA and phosphamide mustard produced by human CYP2B6, CYP2C9, CYP2C19, and CYP3A4 are suggested to be major determinants of micronucleus induction by CPA.	Dimethoate	48-59	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	102-109
30678826-13	2019	Additionally, CPA metabolites like 4-OH-CPA and phosphamide mustard produced by human CYP2B6, CYP2C9, CYP2C19, and CYP3A4 are suggested to be major determinants of micronucleus induction by CPA.	Dimethoate	48-59	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	115-121
30243730-3	2019	Our results show that dimethoate (0.1, 1 and 10 muM) induced a concentration-dependent inhibition of cholinesterase enzymatic activity at all concentrations tested.	Dimethoate	22-32	butyrylcholinesterase	Rattus norvegicus	101-115
30672607-8	2019	Enzyme stability was also studied, which exhibited that immobilized AChE retained its catalytic activity up to 60 days and retained 80% of the hydrolytic activity even at 37 C. On the basis of the success of immobilized enzyme (covalent) being inhibited by acetylthiocholine, the sensor was administered for the inhibition by monocrotophos and dimethoate that are used widely as pesticides in agricultural.	Dimethoate	344-354	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
30672607-9	2019	The inhibitory concentration (IC50 ) value was found to be 2.5 ppb for monocrotophos and 1.5 ppb for dimethoate inhibiting immobilized AChE.	Dimethoate	101-111	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
30340169-6	2019	Deltamethrin resulted in induction of the cyp9q2 transcript at 0.53 ng/bee, while dimethoate led to induction of vitellogenin on the mRNA and protein level at 2 ng/bee.	Dimethoate	82-92	vitellogenin	Apis mellifera	113-125
29102081-0	2017	Phosphamide-containing diphenylpyrimidine analogues (PA-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with enhanced activity against pancreatic cancer cell lines.	Dimethoate	0-11	protein tyrosine kinase 2	Homo sapiens	73-94
29965672-5	2018	Among the OPPs, there were o, o-dimethyl-o-2,2-dichlorovinylphosphate and o,o-dimethyl methylcarbamoylmethyl phosphorodithioate, with maximum values of 7.1 ng L-1 and 17.7 ng L-1, respectively.	Dimethoate	74-127	immunoglobulin kappa variable 1-16	Homo sapiens	159-162
29965672-5	2018	Among the OPPs, there were o, o-dimethyl-o-2,2-dichlorovinylphosphate and o,o-dimethyl methylcarbamoylmethyl phosphorodithioate, with maximum values of 7.1 ng L-1 and 17.7 ng L-1, respectively.	Dimethoate	74-127	immunoglobulin kappa variable 1-16	Homo sapiens	175-178
29102081-0	2017	Phosphamide-containing diphenylpyrimidine analogues (PA-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with enhanced activity against pancreatic cancer cell lines.	Dimethoate	0-11	protein tyrosine kinase 2	Homo sapiens	96-99
29102081-1	2017	A family of phosphamide-containing diphenylpyrimidine analogues (PA-DPPYs) were synthesized as potent focal adhesion kinase (FAK) inhibitors.	Dimethoate	12-23	protein tyrosine kinase 2	Homo sapiens	102-123
29102081-1	2017	A family of phosphamide-containing diphenylpyrimidine analogues (PA-DPPYs) were synthesized as potent focal adhesion kinase (FAK) inhibitors.	Dimethoate	12-23	protein tyrosine kinase 2	Homo sapiens	125-128
28264041-9	2017	CONCLUSION: Bans of paraquat, dimethoate and fenthion in Sri Lanka were associated with a reduction in pesticide suicide mortality and in overall suicide mortality despite a small rise in other methods.	Dimethoate	30-40	sorcin	Homo sapiens	57-60
27441385-0	2017	Synergistic toxicity of zno nanoparticles and dimethoate in mice: Enhancing their biodistribution by synergistic binding of serum albumin and dimethoate to zno nanoparticles.	Dimethoate	46-56	albumin	Mus musculus	130-137
25082528-1	2015	Combined in vivo and in silico studies were undertaken to gain insights into the change in mammalian brain acetylcholinesterase (AChE) activity under acute toxicity conditions in response to two representatives of organophosphates (OPs)--dichlorvos (DCV) and dimethoate (DM).	Dimethoate	259-269	acetylcholinesterase	Rattus norvegicus	107-127
26335275-7	2015	The increased accumulations of dimethoate and Zn in the liver reduced its cholinesterase activity from 5.64 +- 0.45 U/mg protein to 4.67 +- 0.42 U/mg protein or 4.76 +- 0.45 U/mg protein for nano or bulk ZnO, respectively.	Dimethoate	31-41	butyrylcholinesterase	Mus musculus	74-88
27260432-5	2016	The detection limits of paraoxon and dimethoate were 0.7nM and 3.9nM, which were lower than the reported AChE biosensor.	Dimethoate	37-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109
26041283-8	2015	The covalent linking between nsP1 and m(7)GMP involves a phosphamide bond between the nucleotide and a histidine residue.	Dimethoate	57-68	SH2 domain containing 3A	Homo sapiens	29-33
26041283-8	2015	The covalent linking between nsP1 and m(7)GMP involves a phosphamide bond between the nucleotide and a histidine residue.	Dimethoate	57-68	5'-nucleotidase, cytosolic II	Homo sapiens	42-45
25082528-1	2015	Combined in vivo and in silico studies were undertaken to gain insights into the change in mammalian brain acetylcholinesterase (AChE) activity under acute toxicity conditions in response to two representatives of organophosphates (OPs)--dichlorvos (DCV) and dimethoate (DM).	Dimethoate	259-269	acetylcholinesterase (Cartwright blood group)	Homo sapiens	129-133
24875908-3	2014	The binding abilities of pesticides to CAT followed the order: fenvalerate>deltamethrin>disulfoton>isofenphos-methyl>carbaryl>malathion>isocarbophos>dimethoate>dipterex>acephate>methomyl>methamidophos, which was generally similar to the order of determination sensitivity of pesticides.	Dimethoate	170-180	catalase	Homo sapiens	39-42
23891859-4	2013	Dimethoate increased mRNA levels of tumor necrosis factor alpha (TNFalpha) and interleukin (IL) 6 in the hippocampus, and increased the proportion of Iba1 immunoreactive cells with reactive phenotype in dentate gyrus and striatum.	Dimethoate	0-10	tumor necrosis factor	Mus musculus	36-63
24084001-5	2013	On the basis of the AChE inhibition principle, a novel on-chip enzymatic microreactor was constructed for analyzing dimethoate which is usually used as a model of organophosphorus pesticides.	Dimethoate	116-126	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
24084001-6	2013	Under optimal conditions, a linear relationship between the inhibition rates of AChE and the concentration of dimethoate from 1 to 20 mugL(-1) with a detection limit of 0.18 mugL(-1) (S/N=3) was obtained.	Dimethoate	110-120	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
23943137-5	2014	Estradiol decreased the mRNA levels of IL6, IP10, TNFalpha, and IL1beta in male but not in female cultures treated with DMT.	Dimethoate	120-123	interleukin 1 beta	Rattus norvegicus	64-71
24724477-1	2014	The study was undertaken to examine the effect of single and combined administration of dimethoate (an OP insecticide) and pyrantel embonate (an anthelmintic agent) on the concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx) and glutathione reductase (GR) in rats.	Dimethoate	88-98	glutathione-disulfide reductase	Rattus norvegicus	268-289
24724477-1	2014	The study was undertaken to examine the effect of single and combined administration of dimethoate (an OP insecticide) and pyrantel embonate (an anthelmintic agent) on the concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx) and glutathione reductase (GR) in rats.	Dimethoate	88-98	glutathione-disulfide reductase	Rattus norvegicus	291-293
24724477-6	2014	Dimethoate administration caused disturbances in the antioxidative system manifested as a decrease in GSH concentration in the liver (max.--37.7% after 6 hours) and an increase of GPx and GR activities in erythrocytes (max.--21.7% and 29.6% after 3 hours, respectively), compared to the control group.	Dimethoate	0-10	glutathione-disulfide reductase	Rattus norvegicus	188-190
24459918-0	2013	[Impacts that dimethoate inhibited the benchmark dose of acetylcholinesterase based on experimental designs].	Dimethoate	14-24	acetylcholinesterase	Rattus norvegicus	57-77
24459918-3	2013	Rats were sacrificed, and acetylcholinesterase (AChE) activity in the hippocampus, cerebral cortex and serum of rats was determined after dimethoate was ig given to rats for 21 d. And then, the software package PROAST28.1 was applied to calculate the BMD.	Dimethoate	138-148	acetylcholinesterase	Rattus norvegicus	48-52
23891859-4	2013	Dimethoate increased mRNA levels of tumor necrosis factor alpha (TNFalpha) and interleukin (IL) 6 in the hippocampus, and increased the proportion of Iba1 immunoreactive cells with reactive phenotype in dentate gyrus and striatum.	Dimethoate	0-10	tumor necrosis factor	Mus musculus	65-73
23891859-4	2013	Dimethoate increased mRNA levels of tumor necrosis factor alpha (TNFalpha) and interleukin (IL) 6 in the hippocampus, and increased the proportion of Iba1 immunoreactive cells with reactive phenotype in dentate gyrus and striatum.	Dimethoate	0-10	interleukin 6	Mus musculus	79-97
23891859-4	2013	Dimethoate increased mRNA levels of tumor necrosis factor alpha (TNFalpha) and interleukin (IL) 6 in the hippocampus, and increased the proportion of Iba1 immunoreactive cells with reactive phenotype in dentate gyrus and striatum.	Dimethoate	0-10	induction of brown adipocytes 1	Mus musculus	150-154
23891859-6	2013	Some of the effects of lipopolysaccharide (proportion of Iba1 immunoreactive cells with reactive phenotype and IL6 mRNA levels) were amplified in the animals treated with dimethoate, but only in the striatum.	Dimethoate	171-181	induction of brown adipocytes 1	Mus musculus	57-61
23891859-6	2013	Some of the effects of lipopolysaccharide (proportion of Iba1 immunoreactive cells with reactive phenotype and IL6 mRNA levels) were amplified in the animals treated with dimethoate, but only in the striatum.	Dimethoate	171-181	interleukin 6	Mus musculus	111-114
21861917-4	2011	The second group was preincubated with quercetin for 30 min and followed by Dim incubation for 4 h at 37 C. RESULTS: Following in vitro incubation, Dimethoate caused a significant increase in malondialdehyde levels, a significant decrease in thiol levels, as well as a significant increase in superoxide dismutase, and catalase activities in lymphocytes at different concentrations.	Dimethoate	148-158	catalase	Homo sapiens	319-327
22043703-12	2011	Transcription level of NR2B increased to 1.59 and 2.22 folds of 100 micromol/L dimethoate group (P < 0.01) and had big differences with control group (P < 0.01).	Dimethoate	79-89	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	23-27
23599799-5	2013	Different doses of dimethoate all upregulated the expression of p16, Bcl-2 and c-myc genes in mouse gastric tissue.	Dimethoate	19-29	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	64-67
23599799-5	2013	Different doses of dimethoate all upregulated the expression of p16, Bcl-2 and c-myc genes in mouse gastric tissue.	Dimethoate	19-29	B cell leukemia/lymphoma 2	Mus musculus	69-74
21861917-6	2011	CONCLUSION: In conclusion, antioxidant quercetin could protect against Dimethoate-induced oxidative stress by decreasing lipid peroxidation, protein oxidation and increasing superoxide dismutase and catalase activities in human lymphocytes.	Dimethoate	71-81	catalase	Homo sapiens	199-207
18625401-6	2008	In addition, remaining activity of acetylcholinesterase enzyme (AChE) after dimethoate inhibition was higher in genotypes carrying the mutation.	Dimethoate	76-86	acetylcholinesterase	Bactrocera oleae	35-55
19917271-6	2010	In the present study, in vitro enzyme-kinetic and pharmacokinetic data from a minipig model of dimethoate poisoning and oxime treatment were used to calculate dynamic changes of AChE activities.	Dimethoate	95-105	acetylcholinesterase (Cartwright blood group)	Homo sapiens	178-182
17897769-0	2007	Evidences for CYP3A4 autoactivation in the desulfuration of dimethoate by the human liver.	Dimethoate	60-70	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	14-20
17587496-10	2008	Of all four membranes, NF90 showed the best performance in retention of dimethoate and atrazine in water.	Dimethoate	72-82	interleukin enhancer binding factor 3	Homo sapiens	23-27
18055106-7	2008	Thus, NF90 is deemed the more suitable nanofiltration membrane for atrazine and dimethoate retention from aqueous solution compared to NF200, NF270 and DK.	Dimethoate	80-90	interleukin enhancer binding factor 3	Homo sapiens	6-10
18763491-2	2008	It was found that the dimethoate degradations under the individual ultrasonic radiation treatment without O3 (US), the oxidation of O3 gas (O3) and the synergetic effect of UALR and O3 (UALR/O3) were all consonant with the apparent first-order reaction by the kinetics investigations.	Dimethoate	22-32	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	173-184
18763491-2	2008	It was found that the dimethoate degradations under the individual ultrasonic radiation treatment without O3 (US), the oxidation of O3 gas (O3) and the synergetic effect of UALR and O3 (UALR/O3) were all consonant with the apparent first-order reaction by the kinetics investigations.	Dimethoate	22-32	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	186-193
18763491-3	2008	The dimethoate removal rates of US, O3 and UALR/O3 methodologies under the conditions of dimethoate initial concentration of 50 mg/L, initial solution pH of 6.0, dimethoate solution volume of 80 mL, ultrasonic intensity of 0.5 W/cm2, O3 flow of 200 L/h, temperature of 20 degrees C and the treatment time of 4 h were 27%, 15% and 90%, respectively.	Dimethoate	4-14	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	43-50
18384757-3	2008	Isodimethoate shows an inhibition rate constant towards human red blood cell acetylcholinesterase (AChE) of 2.3x10(3) M(-1) min(-1) (pH 7.4, 37 degrees C), indicating a somewhat higher potency than found with omethoate, the CYP450-mediated active metabolite of pure dimethoate.	Dimethoate	3-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-97
18384757-3	2008	Isodimethoate shows an inhibition rate constant towards human red blood cell acetylcholinesterase (AChE) of 2.3x10(3) M(-1) min(-1) (pH 7.4, 37 degrees C), indicating a somewhat higher potency than found with omethoate, the CYP450-mediated active metabolite of pure dimethoate.	Dimethoate	3-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
18384757-9	2008	The clinical consequences of exposure to or intentional ingestion of isodimethoate-containing dimethoate formulations are a partly untractable AChE shortly after incorporation.	Dimethoate	72-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	143-147
18384757-10	2008	In fact, aging of AChE in dimethoate-poisoned patients on admission was much more advanced than expected from the reaction with omethoate.	Dimethoate	26-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-22
16708891-3	2006	Purified and lyophilized AChE from different (NH4)2SO4 precipitated fractions of three brain parts were utilized for in vitro enzyme kinetics using Dimethoate (Dmt) as inhibitor.	Dimethoate	148-158	acetylcholinesterase	Rattus norvegicus	25-29
18070496-8	2007	CONCLUSION: After the treatment of PAM-Cl, the AChE activities of the patients with acute methamidophos poisoning could be continuously reactivated, the AChE activities of the patients with acute DDV/DEP poisoning could also be reactivated in 12 hours, and then keep stable, but the AChE activities of the patients with acute omethoate/dimethoate poisoning could not be reactivated.	Dimethoate	336-346	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	35-38
17997881-8	2007	AChE activity was significantly reduced 42% approximately 78% by all three doses of dimethoate (P < 0.05).	Dimethoate	84-94	acetylcholinesterase	Rattus norvegicus	0-4
16833148-3	2006	We compared the effects of single or repeated (hourly and daily) exposure to dimethoate on acetylcholinesterase (AChE) activity in laboratory mice to assess the suitability of standard laboratory tests for assessing risk.	Dimethoate	77-87	acetylcholinesterase	Mus musculus	91-111
16833148-3	2006	We compared the effects of single or repeated (hourly and daily) exposure to dimethoate on acetylcholinesterase (AChE) activity in laboratory mice to assess the suitability of standard laboratory tests for assessing risk.	Dimethoate	77-87	acetylcholinesterase	Mus musculus	113-117
16833148-9	2006	Cytochrome P450 enzyme activity (CYP2B) was inhibited in the dimethoate-dosed mice.	Dimethoate	61-71	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	33-38
17590326-4	2007	Four pesticides of carbaryl, malathion, dimethoate and monocrotophos were selected to discuss their inhibition efficiencies to AChE.	Dimethoate	40-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
16708891-3	2006	Purified and lyophilized AChE from different (NH4)2SO4 precipitated fractions of three brain parts were utilized for in vitro enzyme kinetics using Dimethoate (Dmt) as inhibitor.	Dimethoate	160-163	acetylcholinesterase	Rattus norvegicus	25-29
16496292-8	2006	CONCLUSIONS: On the basis of the present results dimethoate can produce clinical signs of toxicity and significant inhibition of the maternal and fetal AChE activities in dose groups of 15 and 28 mg/kg/day and showed fetotoxicity without teratogenic effects at 28 mg/kg/day.	Dimethoate	49-59	acetylcholinesterase	Rattus norvegicus	152-156
16701032-0	2006	[Effect of dimethoate on the expression of heat shock protein 70 in peripheral blood lymphocytes of human beings].	Dimethoate	11-21	heat shock protein family A (Hsp70) member 4	Homo sapiens	43-64
16701032-1	2006	OBJECTIVE: To study the effect of dimethoate on the expression of heat shock protein 70 (HSP70) in peripheral blood lymphocytes of human beings and to explore the feasibility of HSP70 in biomonitoring among workers exposed to organophosphorous pesticides.	Dimethoate	34-44	heat shock protein family A (Hsp70) member 4	Homo sapiens	66-87
16701032-1	2006	OBJECTIVE: To study the effect of dimethoate on the expression of heat shock protein 70 (HSP70) in peripheral blood lymphocytes of human beings and to explore the feasibility of HSP70 in biomonitoring among workers exposed to organophosphorous pesticides.	Dimethoate	34-44	heat shock protein family A (Hsp70) member 4	Homo sapiens	89-94
16701032-3	2006	Flow cytometry was used for detecting both the basic level and the level of the dimethoate-induced expression of HSP70.	Dimethoate	80-90	heat shock protein family A (Hsp70) member 4	Homo sapiens	113-118
16701032-10	2006	The factors that had significant influence on the HSP70 basic level of the exposure group were the health condition, the environmental concentration of dimethoate and the exposure time in order, according to their significance of influence.	Dimethoate	152-162	heat shock protein family A (Hsp70) member 4	Homo sapiens	50-55
16701032-13	2006	After the treatment of dimethoate in vitro, the level of the induced expression of HSP70 in the control group was significantly higher than that of the exposure group (P < 0.01).	Dimethoate	23-33	heat shock protein family A (Hsp70) member 4	Homo sapiens	83-88
16701032-16	2006	CONCLUSION: HSP70 is a potential index that can reflect the individual and environmental conditions of workers exposed to dimethoate comprehensively.	Dimethoate	122-132	heat shock protein family A (Hsp70) member 4	Homo sapiens	12-17
16112789-11	2005	This study concludes that oxidative stress due to dimethoate may be ascribed to induction of Cytochrome P450, inhibition of AChE and disturbance in activities of GSH and GST enzymes causing lipid peroxidation and histological and electron microscopic changes in liver and brain.	Dimethoate	50-60	acetylcholinesterase	Rattus norvegicus	124-128
16573274-0	2006	Residues of dimethoate in the liver and AchE activity in blood of rats after exposure to dimethoate, and dimethoate and pyrantel embonate.	Dimethoate	89-99	acetylcholinesterase	Rattus norvegicus	40-44
16573274-0	2006	Residues of dimethoate in the liver and AchE activity in blood of rats after exposure to dimethoate, and dimethoate and pyrantel embonate.	Dimethoate	89-99	acetylcholinesterase	Rattus norvegicus	40-44
16573274-6	2006	Dimethoate in both applied doses significantly reduced AChE activity in blood.	Dimethoate	0-10	acetylcholinesterase	Rattus norvegicus	55-59
16156589-2	2005	Three laboratory strains selected by tetrachlorvinphos, lindane (gamma-HCH) and dimethoate, respectively, had significantly elevated CDNB- and DCNB-GST activities.	Dimethoate	80-90	glutathione S-transferase	Musca domestica	148-151
16243090-9	2005	Acetylcholinesterase inhibited by fenthion or dimethoate responded poorly to pralidoxime treatment compared with chlorpyrifos-inhibited acetylcholinesterase.	Dimethoate	46-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
16156589-6	2005	GST-R was likely to be involved in gamma-HCH resistance in strain 17e, tetrachlorvinphos resistance in strain 39m2b, and dimethoate resistance in strain 49r2b.	Dimethoate	121-131	glutathione S-transferase	Musca domestica	0-3
15863258-0	2005	Functional changes of nicotinic acetylcholine receptor in muscle and lymphocyte of myasthenic rats following acute dimethoate poisoning.	Dimethoate	115-125	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	22-54
15863258-5	2005	In this study, we attempted to investigate temporal and spatial changes of nAChR in the blood lymphocyte, muscle and brain of rats during the course of myasthenia after acute dimethoate poisoning by using radioligand-binding assay.	Dimethoate	175-185	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	75-80
15863258-6	2005	We found that specific nAChR binding activity in the gastrocnemius muscle and blood lymphocytes of myasthenia rats was significantly increased at 48h after dimethoate poisoning.	Dimethoate	156-166	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	23-28