PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10048159-9	1999	The strong positive association between low dietary carbohydrate, enhanced CYP2E1 induction and hepatic necrosis suggests that in the presence of low carbohydrate intake, ethanol induction of CYP2E1 is enhanced to levels sufficient to cause necrosis, possibly through reactive oxygen species and other free radicals generated by CYP2E1 metabolism of ethanol and unsaturated fatty acids.	Fatty Acids, Unsaturated	362-385	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	192-198
10048159-9	1999	The strong positive association between low dietary carbohydrate, enhanced CYP2E1 induction and hepatic necrosis suggests that in the presence of low carbohydrate intake, ethanol induction of CYP2E1 is enhanced to levels sufficient to cause necrosis, possibly through reactive oxygen species and other free radicals generated by CYP2E1 metabolism of ethanol and unsaturated fatty acids.	Fatty Acids, Unsaturated	362-385	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	192-198
9841872-0	1998	Activation of phospholipase A2 in human neutrophils by polyunsaturated fatty acids and its role in stimulation of superoxide production.	Fatty Acids, Unsaturated	55-82	phospholipase A2 group IB	Homo sapiens	14-30
9862669-6	1998	The PLD activity in lysate from control untreated cells was stimulated by unsaturated fatty acids (UFA), but not by guanosine 5"-O-(3-thiotriphosphate).	Fatty Acids, Unsaturated	74-97	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
9862669-6	1998	The PLD activity in lysate from control untreated cells was stimulated by unsaturated fatty acids (UFA), but not by guanosine 5"-O-(3-thiotriphosphate).	Fatty Acids, Unsaturated	99-102	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
9862669-7	1998	However, the PLD activity in the apoptotic cell lysate was no longer enhanced by the addition of oleate, suggesting that the increased PLD activity during apoptosis was attributed to the PLD of UFA-dependent type, but not the small G protein-dependent one.	Fatty Acids, Unsaturated	194-197	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	13-16
9862669-7	1998	However, the PLD activity in the apoptotic cell lysate was no longer enhanced by the addition of oleate, suggesting that the increased PLD activity during apoptosis was attributed to the PLD of UFA-dependent type, but not the small G protein-dependent one.	Fatty Acids, Unsaturated	194-197	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	135-138
9862669-7	1998	However, the PLD activity in the apoptotic cell lysate was no longer enhanced by the addition of oleate, suggesting that the increased PLD activity during apoptosis was attributed to the PLD of UFA-dependent type, but not the small G protein-dependent one.	Fatty Acids, Unsaturated	194-197	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	135-138
9862669-11	1998	This is the first demonstration that the PLD of UFA-dependent type would be involved in cellular responses.	Fatty Acids, Unsaturated	48-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	41-44
9888649-6	1998	Attenuated responses to high PUFA meals appear to be due to greater rates of clearance and greater activation of lipoprotein lipase (LPL).	Fatty Acids, Unsaturated	29-33	lipoprotein lipase	Homo sapiens	113-131
9888649-6	1998	Attenuated responses to high PUFA meals appear to be due to greater rates of clearance and greater activation of lipoprotein lipase (LPL).	Fatty Acids, Unsaturated	29-33	lipoprotein lipase	Homo sapiens	133-136
9876868-5	1998	Polyunsaturated fatty acids are released from membrane phospholipids by a number of enzymic mechanisms involving the receptor-mediated stimulation of phospholipase A2 and phospholipase C/diacylglycerol lipase pathways.	Fatty Acids, Unsaturated	0-27	phospholipase A2 group IB	Homo sapiens	150-166
9885775-10	1998	The potential significance of the HL pathway is that it provides the hepatocyte with a mechanism for the uptake of a subset of phospholipids enriched in unsaturated fatty acids and may allow the uptake of cholesteryl ester, free cholesterol, and phospholipid without catabolism of HDL apolipoproteins.	Fatty Acids, Unsaturated	153-176	lipase C, hepatic type	Homo sapiens	34-36
9881500-4	1998	However, glutathione transferase, glutathione reductase, glutathione peroxidase, and catalase activities were lower in the group treated with n-3 polyunsaturated fatty acids than in the groups fed with either the monounsaturated or the n-6 + n-3 polyunsaturated enriched diet.	Fatty Acids, Unsaturated	146-173	glutathione-disulfide reductase	Rattus norvegicus	34-55
9831630-0	1998	Effect of long chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine on the interaction with recombinant high density lipoprotein apolipoprotein A-I.	Fatty Acids, Unsaturated	21-48	apolipoprotein A1	Homo sapiens	154-172
9813046-0	1998	Peroxisomal Delta3-cis-Delta2-trans-enoyl-CoA isomerase encoded by ECI1 is required for growth of the yeast Saccharomyces cerevisiae on unsaturated fatty acids.	Fatty Acids, Unsaturated	136-159	dodecenoyl-CoA isomerase	Saccharomyces cerevisiae S288C	67-71
9813046-1	1998	We have identified the Saccharomyces cerevisiae gene ECI1 encoding Delta3-cis-Delta2-trans-enoyl-CoA isomerase that acts as an auxiliary enzyme in the beta-oxidation of (poly)unsaturated fatty acids.	Fatty Acids, Unsaturated	169-198	dodecenoyl-CoA isomerase	Saccharomyces cerevisiae S288C	53-57
9813046-2	1998	A mutant devoid of Eci1p was unable to grow on media containing unsaturated fatty acids such as oleic acid but was proficient for growth when a saturated fatty acid such as palmitic acid was the sole carbon source.	Fatty Acids, Unsaturated	64-87	dodecenoyl-CoA isomerase	Saccharomyces cerevisiae S288C	19-24
9840740-5	1998	However, it seems possible that in extracellular fluid, which contains a high concentration of calcium and a low concentration of albumin, hemoprotein released from damaged cells could oxidize unsaturated fatty acids derived by phospholipase-A2 from phospholipids of damaged cellular membranes.	Fatty Acids, Unsaturated	193-216	phospholipase A2 group IB	Homo sapiens	228-244
9784195-6	1998	Polyunsaturated fatty acids of each phospholipid were preferentially decreased with lipoxygenase, and degrees of the changes of the phospholipid classes corresponded to the amount of polyunsaturated fatty acids of each phospholipid.	Fatty Acids, Unsaturated	0-27	linoleate 9S-lipoxygenase-4	Glycine max	84-96
9812904-0	1998	Unsaturated fatty acids increase plasminogen activator inhibitor-1 expression in endothelial cells.	Fatty Acids, Unsaturated	0-23	serpin family E member 1	Homo sapiens	33-66
9812904-14	1998	In conclusion, the present study demonstrates that unsaturated fatty acids increase PAI-1 transcription and secretion by endothelial cells in vitro.	Fatty Acids, Unsaturated	51-74	serpin family E member 1	Homo sapiens	84-89
9867800-1	1998	Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is a key enzyme in the synthesis polyunsaturated fatty acids.	Fatty Acids, Unsaturated	77-104	stearoyl-CoA desaturase	Homo sapiens	0-23
9867800-1	1998	Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is a key enzyme in the synthesis polyunsaturated fatty acids.	Fatty Acids, Unsaturated	77-104	stearoyl-CoA desaturase	Homo sapiens	25-28
9771867-1	1998	BACKGROUND: Infusion of lipid emulsions rich in polyunsaturated fatty acids (PUFAs) may increase lipid peroxidation, which is counteracted mainly by superoxide dismutase (SOD) (a zinc-, copper-, and manganese-dependent enzyme), selenium-dependent glutathione peroxidase (Se-GSHPx), and alpha-tocopherol.	Fatty Acids, Unsaturated	48-75	superoxide dismutase 1	Homo sapiens	149-169
9771867-1	1998	BACKGROUND: Infusion of lipid emulsions rich in polyunsaturated fatty acids (PUFAs) may increase lipid peroxidation, which is counteracted mainly by superoxide dismutase (SOD) (a zinc-, copper-, and manganese-dependent enzyme), selenium-dependent glutathione peroxidase (Se-GSHPx), and alpha-tocopherol.	Fatty Acids, Unsaturated	48-75	superoxide dismutase 1	Homo sapiens	171-174
9771867-1	1998	BACKGROUND: Infusion of lipid emulsions rich in polyunsaturated fatty acids (PUFAs) may increase lipid peroxidation, which is counteracted mainly by superoxide dismutase (SOD) (a zinc-, copper-, and manganese-dependent enzyme), selenium-dependent glutathione peroxidase (Se-GSHPx), and alpha-tocopherol.	Fatty Acids, Unsaturated	77-82	superoxide dismutase 1	Homo sapiens	149-169
9771867-1	1998	BACKGROUND: Infusion of lipid emulsions rich in polyunsaturated fatty acids (PUFAs) may increase lipid peroxidation, which is counteracted mainly by superoxide dismutase (SOD) (a zinc-, copper-, and manganese-dependent enzyme), selenium-dependent glutathione peroxidase (Se-GSHPx), and alpha-tocopherol.	Fatty Acids, Unsaturated	77-82	superoxide dismutase 1	Homo sapiens	171-174
9794815-3	1998	Polyunsaturated fatty acids and eicosanoids bind and activate PPARgamma, suggesting that these lipids may serve as hormonal regulators of a variety of biological processes.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor gamma	Homo sapiens	62-71
9802534-6	1998	Ethanol induction of CYP2E1 was related to the concentration of polyunsaturated fatty acids in the diet; induction of CYP4A by ethanol was seen in all groups.	Fatty Acids, Unsaturated	64-91	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	21-27
9788241-0	1998	Polyunsaturated fatty acids inhibit the expression of the glucose-6-phosphate dehydrogenase gene in primary rat hepatocytes by a nuclear posttranscriptional mechanism.	Fatty Acids, Unsaturated	0-27	glucose-6-phosphate dehydrogenase	Rattus norvegicus	58-91
9788241-1	1998	Expression of the glucose-6-phosphate dehydrogenase (G6PD) gene is inhibited by the addition of polyunsaturated fatty acids to the medium of primary hepatocytes in culture.	Fatty Acids, Unsaturated	96-123	glucose-6-phosphate dehydrogenase	Rattus norvegicus	18-51
9788241-1	1998	Expression of the glucose-6-phosphate dehydrogenase (G6PD) gene is inhibited by the addition of polyunsaturated fatty acids to the medium of primary hepatocytes in culture.	Fatty Acids, Unsaturated	96-123	glucose-6-phosphate dehydrogenase	Rattus norvegicus	53-57
9788241-7	1998	The decrease in G6PD pre-mRNA accumulation caused by arachidonic acid was also observed with other long chain polyunsaturated fatty acids but not with monounsaturated fatty acids.	Fatty Acids, Unsaturated	110-137	glucose-6-phosphate dehydrogenase	Rattus norvegicus	16-20
9811234-3	1998	Opsin, rhodopsin and phospholipase A2 (PLA2) are located in excitable membranes of retina which are enriched with polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	114-141	rhodopsin	Rattus norvegicus	7-16
9811234-3	1998	Opsin, rhodopsin and phospholipase A2 (PLA2) are located in excitable membranes of retina which are enriched with polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	114-141	phospholipase A2 group IB	Rattus norvegicus	21-37
9811234-3	1998	Opsin, rhodopsin and phospholipase A2 (PLA2) are located in excitable membranes of retina which are enriched with polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	114-141	phospholipase A2 group IB	Rattus norvegicus	39-43
9777755-2	1998	In addition to its responsiveness to thyroid hormone, S14 gene transcription is controlled by dietary substrates, such as glucose and polyunsaturated fatty acids, and by fuel-related hormones including insulin and glucagon.	Fatty Acids, Unsaturated	134-161	thyroid hormone responsive	Homo sapiens	54-57
9811234-3	1998	Opsin, rhodopsin and phospholipase A2 (PLA2) are located in excitable membranes of retina which are enriched with polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	143-147	rhodopsin	Rattus norvegicus	7-16
9811234-3	1998	Opsin, rhodopsin and phospholipase A2 (PLA2) are located in excitable membranes of retina which are enriched with polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	143-147	phospholipase A2 group IB	Rattus norvegicus	21-37
9811234-3	1998	Opsin, rhodopsin and phospholipase A2 (PLA2) are located in excitable membranes of retina which are enriched with polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	143-147	phospholipase A2 group IB	Rattus norvegicus	39-43
9753449-7	1998	Various unsaturated fatty acids at sn-1 also were transferred by human LCAT at a higher rate (5-75% of total) than they were transferred by rat LCAT (0-21%).	Fatty Acids, Unsaturated	8-31	lecithin-cholesterol acyltransferase	Homo sapiens	71-75
9724698-3	1998	Moreover, studies of protein functionality demonstrate that the PIOX recombinant protein possesses at least one of the two enzymatic activities of PGHSs, that of catalyzing the oxygenation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	192-219	alpha-dioxygenase 1-like	Nicotiana tabacum	64-68
9719086-0	1998	Effects of monounsaturated and polyunsaturated fatty acids (omega-3 and omega-6) on Brca1 protein expression in breast cell lines.	Fatty Acids, Unsaturated	31-58	BRCA1 DNA repair associated	Homo sapiens	84-89
9703957-3	1998	Here we report the finding of four novel FAAH inhibitors, two of which, malhamensilipin A and grenadadiene, were screened out of a series of thirty-two different algal natural products, and two others, arachidonoylethylene glycol (AEG) and arachidonoyl-serotonin (AA-5-HT) were selected out of five artificially functionalized polyunsaturated fatty acids.	Fatty Acids, Unsaturated	327-354	fatty-acid amide hydrolase-like	Rattus norvegicus	41-45
9693089-1	1998	Lipoxygenase (LOX) is an enzyme that regioselectively introduces the hydroperoxide functionality into polyunsaturated fatty acids, such as linoleic acid (LA).	Fatty Acids, Unsaturated	102-129	linoleate 9S-lipoxygenase-4	Glycine max	0-12
9693089-1	1998	Lipoxygenase (LOX) is an enzyme that regioselectively introduces the hydroperoxide functionality into polyunsaturated fatty acids, such as linoleic acid (LA).	Fatty Acids, Unsaturated	102-129	linoleate 9S-lipoxygenase-4	Glycine max	14-17
9814727-0	1998	Polyunsaturated fatty acids in school children in relation to allergy and serum IgE levels.	Fatty Acids, Unsaturated	0-27	immunoglobulin heavy constant epsilon	Homo sapiens	80-83
9814727-1	1998	Altered composition of polyunsaturated fatty acids (PUFA) has been observed in allergic individuals and it has been proposed that this is due to an impairment of delta-6-desaturase activity.	Fatty Acids, Unsaturated	23-50	fatty acid desaturase 2	Homo sapiens	162-180
9814727-1	1998	Altered composition of polyunsaturated fatty acids (PUFA) has been observed in allergic individuals and it has been proposed that this is due to an impairment of delta-6-desaturase activity.	Fatty Acids, Unsaturated	52-56	fatty acid desaturase 2	Homo sapiens	162-180
9706173-7	1998	RESULTS: Both polyunsaturated fatty acids increase hepatocyte synthesis of acute phase proteins alpha 2-macroglobulin and lipopolysaccharide binding protein compared with controls; however, the response in the docosahexaenoic acid (22:6n-3) treated cultures was significant (P < .05 vs control).	Fatty Acids, Unsaturated	14-41	alpha-2-macroglobulin	Rattus norvegicus	96-117
9706173-7	1998	RESULTS: Both polyunsaturated fatty acids increase hepatocyte synthesis of acute phase proteins alpha 2-macroglobulin and lipopolysaccharide binding protein compared with controls; however, the response in the docosahexaenoic acid (22:6n-3) treated cultures was significant (P < .05 vs control).	Fatty Acids, Unsaturated	14-41	lipopolysaccharide binding protein	Rattus norvegicus	122-156
9706173-8	1998	Interleukin-6 was also increased in the polyunsaturated fatty acid cultures compared with controls (P < .05) vs control).	Fatty Acids, Unsaturated	40-66	interleukin 6	Rattus norvegicus	0-13
9628867-6	1998	A particularly salient feature of TRAAK is that they can be stimulated by arachidonic acid (AA) and other unsaturated fatty acids but not by saturated fatty acids.	Fatty Acids, Unsaturated	106-129	potassium two pore domain channel subfamily K member 4	Homo sapiens	34-39
9684268-8	1998	Monounsaturated fatty acids and omega-3 polyunsaturated fatty acids (PUFAs) suppress TNF and IL-1 production and actions, while n-6 PUFAs exert the opposite effect.	Fatty Acids, Unsaturated	69-74	tumor necrosis factor	Homo sapiens	85-88
9684268-8	1998	Monounsaturated fatty acids and omega-3 polyunsaturated fatty acids (PUFAs) suppress TNF and IL-1 production and actions, while n-6 PUFAs exert the opposite effect.	Fatty Acids, Unsaturated	69-74	interleukin 1 alpha	Homo sapiens	93-97
9630716-5	1998	In conclusion, this study demonstrates that a recombinant human FLAP can stimulate a lipoxygenase other than mammalian 5-lipoxygenase (S.t.LOX) by using different polyunsaturated fatty acids as substrates.	Fatty Acids, Unsaturated	163-190	arachidonate 5-lipoxygenase activating protein	Homo sapiens	64-68
9630716-5	1998	In conclusion, this study demonstrates that a recombinant human FLAP can stimulate a lipoxygenase other than mammalian 5-lipoxygenase (S.t.LOX) by using different polyunsaturated fatty acids as substrates.	Fatty Acids, Unsaturated	163-190	probable linoleate 9S-lipoxygenase 5	Solanum tuberosum	85-97
9630716-5	1998	In conclusion, this study demonstrates that a recombinant human FLAP can stimulate a lipoxygenase other than mammalian 5-lipoxygenase (S.t.LOX) by using different polyunsaturated fatty acids as substrates.	Fatty Acids, Unsaturated	163-190	arachidonate 5-lipoxygenase	Homo sapiens	119-133
9630716-5	1998	In conclusion, this study demonstrates that a recombinant human FLAP can stimulate a lipoxygenase other than mammalian 5-lipoxygenase (S.t.LOX) by using different polyunsaturated fatty acids as substrates.	Fatty Acids, Unsaturated	163-190	lysyl oxidase	Homo sapiens	139-142
9675816-0	1998	Transcriptional co-regulation of Saccharomyces cerevisiae alcohol acetyltransferase gene, ATF1 and delta-9 fatty acid desaturase gene, OLE1 by unsaturated fatty acids.	Fatty Acids, Unsaturated	143-166	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	90-94
9675816-0	1998	Transcriptional co-regulation of Saccharomyces cerevisiae alcohol acetyltransferase gene, ATF1 and delta-9 fatty acid desaturase gene, OLE1 by unsaturated fatty acids.	Fatty Acids, Unsaturated	143-166	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	135-139
9675816-2	1998	ATF1 expression is repressed by unsaturated fatty acids or oxygen.	Fatty Acids, Unsaturated	32-55	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	0-4
9675816-3	1998	Analysis using ATF1-lacZ fusion plasmid revealed that ATF1 gene expression is widely repressed by a variety of unsaturated fatty acids, and the degree of ATF1 transcriptional repression varies according to the structure of the unsaturated fatty acids.	Fatty Acids, Unsaturated	111-134	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	15-19
9675816-3	1998	Analysis using ATF1-lacZ fusion plasmid revealed that ATF1 gene expression is widely repressed by a variety of unsaturated fatty acids, and the degree of ATF1 transcriptional repression varies according to the structure of the unsaturated fatty acids.	Fatty Acids, Unsaturated	111-134	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	54-58
9675816-3	1998	Analysis using ATF1-lacZ fusion plasmid revealed that ATF1 gene expression is widely repressed by a variety of unsaturated fatty acids, and the degree of ATF1 transcriptional repression varies according to the structure of the unsaturated fatty acids.	Fatty Acids, Unsaturated	111-134	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	54-58
9675816-3	1998	Analysis using ATF1-lacZ fusion plasmid revealed that ATF1 gene expression is widely repressed by a variety of unsaturated fatty acids, and the degree of ATF1 transcriptional repression varies according to the structure of the unsaturated fatty acids.	Fatty Acids, Unsaturated	227-250	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	15-19
9675816-3	1998	Analysis using ATF1-lacZ fusion plasmid revealed that ATF1 gene expression is widely repressed by a variety of unsaturated fatty acids, and the degree of ATF1 transcriptional repression varies according to the structure of the unsaturated fatty acids.	Fatty Acids, Unsaturated	227-250	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	54-58
9675816-3	1998	Analysis using ATF1-lacZ fusion plasmid revealed that ATF1 gene expression is widely repressed by a variety of unsaturated fatty acids, and the degree of ATF1 transcriptional repression varies according to the structure of the unsaturated fatty acids.	Fatty Acids, Unsaturated	227-250	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	54-58
9675816-4	1998	Interestingly, it was noted that the degree of ATF1 transcriptional repression was related to the melting point of unsaturated fatty acids added to the medium.	Fatty Acids, Unsaturated	115-138	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	47-51
9675816-5	1998	The OLE1 gene, which encodes delta-9 fatty acid desaturase, has been reported to be repressed by unsaturated fatty acids.	Fatty Acids, Unsaturated	97-120	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	4-8
9675816-6	1998	Transcription of OLE1 was also repressed by a wide variety of unsaturated fatty acids under anaerobic conditions.	Fatty Acids, Unsaturated	62-85	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	17-21
9675816-7	1998	The degree of transcriptional repression of OLE1 was also related to the melting point of the added unsaturated fatty acids.	Fatty Acids, Unsaturated	100-123	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	44-48
9675816-9	1998	As has been reported for OLE1, the repression of ATF1 by unsaturated fatty acids was relieved in a disruptant carrying a faa1 and faa4 double mutation, two fatty acid activation genes.	Fatty Acids, Unsaturated	57-80	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	25-29
9675816-9	1998	As has been reported for OLE1, the repression of ATF1 by unsaturated fatty acids was relieved in a disruptant carrying a faa1 and faa4 double mutation, two fatty acid activation genes.	Fatty Acids, Unsaturated	57-80	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	49-53
9675816-9	1998	As has been reported for OLE1, the repression of ATF1 by unsaturated fatty acids was relieved in a disruptant carrying a faa1 and faa4 double mutation, two fatty acid activation genes.	Fatty Acids, Unsaturated	57-80	long-chain fatty acid-CoA ligase FAA1	Saccharomyces cerevisiae S288C	121-125
9675816-9	1998	As has been reported for OLE1, the repression of ATF1 by unsaturated fatty acids was relieved in a disruptant carrying a faa1 and faa4 double mutation, two fatty acid activation genes.	Fatty Acids, Unsaturated	57-80	long-chain fatty acid-CoA ligase FAA4	Saccharomyces cerevisiae S288C	130-134
9675816-11	1998	These results suggested that ATF1 transcription was co-regulated by the same mechanism as the OLE1 gene and that unsaturated fatty acids and oxygen repressed the ATF1 transcript by a different regulation pathway.	Fatty Acids, Unsaturated	113-136	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	94-98
9675816-11	1998	These results suggested that ATF1 transcription was co-regulated by the same mechanism as the OLE1 gene and that unsaturated fatty acids and oxygen repressed the ATF1 transcript by a different regulation pathway.	Fatty Acids, Unsaturated	113-136	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	162-166
9660301-8	1998	It is proposed that elevated production of reactive oxygen intermediates by cells expressing CYP2E1 can cause lipid peroxidation, which subsequently promotes apoptosis and cell toxicity when the cells are enriched with polyunsaturated fatty acids such as arachidonic acid.	Fatty Acids, Unsaturated	219-246	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	93-99
9689594-1	1998	The effect of phospholipase A2 (PLA2)-dependent release of unsaturated fatty acids (FA) on phospholipase D (PLD) function was examined in purified sarcolemmal (SL) membranes isolated from rat heart.	Fatty Acids, Unsaturated	59-82	phospholipase A2 group IB	Rattus norvegicus	14-30
9678254-0	1998	Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells.	Fatty Acids, Unsaturated	26-53	carnitine palmitoyltransferase 1B	Homo sapiens	103-135
9678254-6	1998	The inhibition of CPT I and subsequent fatty acid oxidation by polyunsaturated fatty acids leads to a significant increase in apoptosis, suggesting that CPT I may be involved in the processes of programmed cell death in Hep2 human tumour cells.	Fatty Acids, Unsaturated	63-90	carnitine palmitoyltransferase 1B	Homo sapiens	18-23
9689594-1	1998	The effect of phospholipase A2 (PLA2)-dependent release of unsaturated fatty acids (FA) on phospholipase D (PLD) function was examined in purified sarcolemmal (SL) membranes isolated from rat heart.	Fatty Acids, Unsaturated	59-82	phospholipase A2 group IB	Rattus norvegicus	32-36
9635881-10	1998	These results demonstrate that dietary n-6 PUFAs upregulate COX-2 and, to some extent, COX-1 expression.	Fatty Acids, Unsaturated	43-48	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	60-65
9635881-10	1998	These results demonstrate that dietary n-6 PUFAs upregulate COX-2 and, to some extent, COX-1 expression.	Fatty Acids, Unsaturated	43-48	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	87-92
9626568-12	1998	Gas chromatographic determinations of linoleic acid in LDL in presence of the MPO system showed that this polyunsaturated fatty acid (PUFA) is easily attacked by HOCl.	Fatty Acids, Unsaturated	106-132	myeloperoxidase	Homo sapiens	78-81
9626568-12	1998	Gas chromatographic determinations of linoleic acid in LDL in presence of the MPO system showed that this polyunsaturated fatty acid (PUFA) is easily attacked by HOCl.	Fatty Acids, Unsaturated	134-138	myeloperoxidase	Homo sapiens	78-81
9566998-10	1998	CLA concentration in milk fat can be enhanced by the addition of polyunsaturated fatty acids to the diet, especially oils high in linoleic acid.	Fatty Acids, Unsaturated	65-92	Weaning weight-maternal milk	Bos taurus	21-25
9626899-2	1998	A strongly oxidizing environment induces fragmentation of the polyunsaturated fatty acids of membrane phospholipids, and the resulting oxidized phospholipids are structurally similar to PAF and mimic its biologic actions.	Fatty Acids, Unsaturated	62-89	PCNA clamp associated factor	Homo sapiens	186-189
9771140-5	1998	Combination of balneofactors with diet including polyunsaturated fatty acids enhanced antioxidant blood activity and modified LPO.	Fatty Acids, Unsaturated	49-76	lactoperoxidase	Homo sapiens	126-129
9630707-0	1998	Decreased membrane fluidity and unsaturated fatty acids in Niemann-Pick disease type C fibroblasts.	Fatty Acids, Unsaturated	32-55	NPC intracellular cholesterol transporter 1	Homo sapiens	59-86
9575843-1	1998	We previously found that dietary unsaturated fatty acids increase cellular retinol-binding protein type II (CRBP II) mRNA and its protein levels in rat jejunum.	Fatty Acids, Unsaturated	33-56	retinol binding protein 2	Rattus norvegicus	66-106
9575843-1	1998	We previously found that dietary unsaturated fatty acids increase cellular retinol-binding protein type II (CRBP II) mRNA and its protein levels in rat jejunum.	Fatty Acids, Unsaturated	33-56	retinol binding protein 2	Rattus norvegicus	108-115
9512478-5	1998	Neo-epitopes were also formed by interaction of the apolipoproteins with degradation products from the lipid peroxidation of polyunsaturated fatty acids, as evidenced by an immunoreaction of oxidized Eu3+-labelled HDL3 with antibodies to 4-hydroxynonenal (4-HNE)- and malondialdehyde (MDA)-protein adducts.	Fatty Acids, Unsaturated	125-152	HDL3	Homo sapiens	214-218
9614698-9	1998	The CTP: phosphocholine cytidylyltransferase (CT) activity in the homogenate was lower in the n-3 PUFA groups, the reduction being more prominent in the eicosapentaenoic and docosahexaenoic acid groups than in the alpha-linolenic acid group.	Fatty Acids, Unsaturated	98-102	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	4-44
9592625-11	1998	The systemic defect in the phospholipid arachidonic acid level may be both of dietary or genetic origin; experimental data suggest that the increase in delta-6 desaturase activity, the limiting enzyme in the metabolic pathway of polyunsaturated fatty acids, might be relevant to the pathogenesis of lipid abnormalities observed in nephrolithiasis and to the pathogenesis of ICN and its related problems (at the kidney, intestinal, and bone level).	Fatty Acids, Unsaturated	229-256	fatty acid desaturase 2	Homo sapiens	152-170
9538254-10	1998	Among the phospholipase A2 hydrolysis products of phospholipids, unsaturated fatty acids (oleate, linoleate, and arachidonate) and lysophospholipid (lysophosphatidylcholine) by themselves broke lysosomes down directly, whereas saturated fatty acids (palmitate and stearate) had little effect.	Fatty Acids, Unsaturated	65-88	phospholipase A2 group IB	Homo sapiens	10-26
9452501-0	1998	IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	102-125	isocitrate dehydrogenase (NADP(+)) IDP3	Saccharomyces cerevisiae S288C	0-4
9536053-7	1998	Therefore, LOX-1 is also a 3Z-alkenal oxygenase, and it exerts the same stereospecificity of oxidation as it does with polyunsaturated fatty acids. Two other LOX isozymes of soybean seed were also found to oxidize NON to 4-HPNE with an excess of 4S-hydroperoxy-stereoisomer.	Fatty Acids, Unsaturated	120-147	seed linoleate 9S-lipoxygenase-3	Glycine max	12-15
9536053-7	1998	Therefore, LOX-1 is also a 3Z-alkenal oxygenase, and it exerts the same stereospecificity of oxidation as it does with polyunsaturated fatty acids. Two other LOX isozymes of soybean seed were also found to oxidize NON to 4-HPNE with an excess of 4S-hydroperoxy-stereoisomer.	Fatty Acids, Unsaturated	120-147	seed linoleate 9S-lipoxygenase-3	Glycine max	159-162
9514943-0	1998	Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	69-96	occludin	Homo sapiens	46-54
9502426-7	1998	CD14 mRNA levels were also significantly elevated in groups fed unsaturated fatty acids with dextrose.	Fatty Acids, Unsaturated	64-87	CD14 molecule	Rattus norvegicus	0-4
9502426-11	1998	Furthermore, unsaturated fatty acids may prime cells to respond to endotoxin by enhancing CD14 expression.	Fatty Acids, Unsaturated	13-36	CD14 molecule	Rattus norvegicus	90-94
9514051-1	1998	This study examined the effect of n-6 polyunsaturated fatty acids (PUFAs) on the expression of nm-23, a metastasis-suppressor gene, in two highly invasive human cancer cell lines, HT115 and MDA MB 231.	Fatty Acids, Unsaturated	67-72	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	95-100
9518257-1	1998	Phosphoenolpyruvate carboxykinase (PEPCK) exerts a glyceroneogenic function in adipocytes in which transcription of its gene is increased by unsaturated fatty acids and fibrates.	Fatty Acids, Unsaturated	141-164	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-33
9518257-1	1998	Phosphoenolpyruvate carboxykinase (PEPCK) exerts a glyceroneogenic function in adipocytes in which transcription of its gene is increased by unsaturated fatty acids and fibrates.	Fatty Acids, Unsaturated	141-164	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	35-40
9450993-7	1998	Our proposal is strongly supported by the observation that peroxisomal Idp3p is essential for growth on the unsaturated fatty acids arachidonic, linoleic and petroselinic acid, which require 2, 4-dienoyl-CoA reductase activity.	Fatty Acids, Unsaturated	108-131	isocitrate dehydrogenase (NADP(+)) IDP3	Saccharomyces cerevisiae S288C	71-76
9452501-7	1998	Yeast cells lacking Idp3p grow normally on saturated fatty acids, but growth is impaired on unsaturated fatty acids, indicating that the peroxisomal Idp3p is involved in their metabolic utilization.	Fatty Acids, Unsaturated	92-115	isocitrate dehydrogenase (NADP(+)) IDP3	Saccharomyces cerevisiae S288C	149-154
9555564-10	1998	UFA (1, 10 or 30 micrograms/ml) markedly inhibited the b-FGF-induced cell proliferation down to the basal value.	Fatty Acids, Unsaturated	0-3	fibroblast growth factor 2	Homo sapiens	55-60
9538194-6	1998	Increased NAD levels were found in both IFN gamma-treated and non-treated hepatocytes following the addition of PUFAs, but clofibrate, a peroxisome proliferator, bromophenacyl bromide (BPB), an inhibitor of phospholipase, nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, and arachidonic acid, a metabolite of linoleic acid, did not inhibit IFN gamma-induced cellular injury.	Fatty Acids, Unsaturated	112-117	interferon gamma	Homo sapiens	40-49
9699015-4	1998	In a similar manner, addition of a polyunsaturated fatty acid such as arachidonic acid produced toxicity to the cells expressing CYP2E1 but not the control cells.	Fatty Acids, Unsaturated	35-61	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	129-135
9678254-6	1998	The inhibition of CPT I and subsequent fatty acid oxidation by polyunsaturated fatty acids leads to a significant increase in apoptosis, suggesting that CPT I may be involved in the processes of programmed cell death in Hep2 human tumour cells.	Fatty Acids, Unsaturated	63-90	carnitine palmitoyltransferase 1B	Homo sapiens	153-158
9503157-3	1998	The polyunsaturated fatty acids, gamma-linolenic and arachidonic acid, caused 60-70% inhibition of tumour cell CPT I activity and 45-50% inhibition of [14C]-palmitic acid oxidation to 14CO2.	Fatty Acids, Unsaturated	4-31	carnitine palmitoyltransferase 1B	Homo sapiens	111-116
9436618-7	1998	On the other hand, the formation of 4-hydroxy-nonenal, a more specific marker of peroxidative damage to polyunsaturated fatty acids, was higher in bcl-2 transfected cells than in control cells.	Fatty Acids, Unsaturated	104-131	BCL2 apoptosis regulator	Homo sapiens	147-152
9483379-0	1997	Unsaturated fatty acids alter the insulin secretion response of the islets of Langerhans in vitro.	Fatty Acids, Unsaturated	0-23	insulin	Homo sapiens	34-41
9801932-0	1998	Effect of HMG-CoA reductase inhibitors on plasma polyunsaturated fatty acid concentrations in patients with hyperlipidemia.	Fatty Acids, Unsaturated	49-75	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	10-27
9801932-1	1998	We investigated the effect of 12 months" HMG-CoA reductase inhibitor treatment on plasma polyunsaturated fatty acid concentrations in 19 patients with hyperlipidemia.	Fatty Acids, Unsaturated	89-115	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	41-58
9680670-0	1998	[Effect of anti-atherosclerotic diet with polyunsaturated fatty acids omega-3 from linseed oil on dynamics of natural antibodies to bradykinin and angiotensin II in blood serum of patients with cardiovascular diseases].	Fatty Acids, Unsaturated	42-69	kininogen 1	Homo sapiens	132-142
9680670-0	1998	[Effect of anti-atherosclerotic diet with polyunsaturated fatty acids omega-3 from linseed oil on dynamics of natural antibodies to bradykinin and angiotensin II in blood serum of patients with cardiovascular diseases].	Fatty Acids, Unsaturated	42-69	angiotensinogen	Homo sapiens	147-161
9698032-1	1998	To elucidate further the role of placental membrane fatty acid-binding protein (p-FABPpm) in preferential transfer of maternal plasma long chain polyunsaturated fatty acids (LCPUFA) across the human placenta, direct binding of the purified protein with various radiolabelled fatty acids (docosahexaenoic, arachidonic, linoleic and oleic acids) was investigated.	Fatty Acids, Unsaturated	145-172	glutamic-oxaloacetic transaminase 2	Homo sapiens	82-88
9558724-0	1998	Polyunsaturated fatty acid inhibition of fatty acid synthase transcription is independent of PPAR activation.	Fatty Acids, Unsaturated	0-26	fatty acid synthase	Rattus norvegicus	41-60
9558724-1	1998	Polyunsaturated fatty acids (PUFA) of the (n-6) and (n-3) families inhibit the rate of gene transcription for a number of hepatic lipogenic and glycolytic genes, e.g., fatty acid synthase (FAS).	Fatty Acids, Unsaturated	0-27	fatty acid synthase	Rattus norvegicus	168-187
9558724-1	1998	Polyunsaturated fatty acids (PUFA) of the (n-6) and (n-3) families inhibit the rate of gene transcription for a number of hepatic lipogenic and glycolytic genes, e.g., fatty acid synthase (FAS).	Fatty Acids, Unsaturated	0-27	fatty acid synthase	Rattus norvegicus	189-192
9558724-1	1998	Polyunsaturated fatty acids (PUFA) of the (n-6) and (n-3) families inhibit the rate of gene transcription for a number of hepatic lipogenic and glycolytic genes, e.g., fatty acid synthase (FAS).	Fatty Acids, Unsaturated	29-33	fatty acid synthase	Rattus norvegicus	168-187
9558724-1	1998	Polyunsaturated fatty acids (PUFA) of the (n-6) and (n-3) families inhibit the rate of gene transcription for a number of hepatic lipogenic and glycolytic genes, e.g., fatty acid synthase (FAS).	Fatty Acids, Unsaturated	29-33	fatty acid synthase	Rattus norvegicus	189-192
9417812-0	1997	Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes.	Fatty Acids, Unsaturated	11-34	interleukin 1 beta	Homo sapiens	38-55
9417812-2	1997	It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide.	Fatty Acids, Unsaturated	147-174	interleukin 1 beta	Homo sapiens	25-42
9417812-2	1997	It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide.	Fatty Acids, Unsaturated	147-174	interleukin 1 beta	Homo sapiens	44-52
9483379-9	1997	In conclusion, culture of islets of Langerhans for a week with high concentrations of unsaturated fatty acids produces a hypersecretion of insulin which is not influenced by secretagogues such as glucose, arginine, or forskolin.	Fatty Acids, Unsaturated	86-109	insulin	Homo sapiens	139-146
9368040-4	1997	At molar oxidant:HDL3 ratios >/= 60:1, we have observed pronounced consumption of HDL3 unsaturated fatty acids with concomitant formation of fatty acid chlorohydrins.	Fatty Acids, Unsaturated	90-113	high density lipoprotein (HDL) level 3	Mus musculus	17-21
9405576-0	1997	Unsaturated fatty acids associated with glycogen may inhibit glucose-6 phosphatase in rat liver.	Fatty Acids, Unsaturated	0-23	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	61-82
9405576-8	1997	The glycogen-associated fractions did not contain complex lipids but contained unsaturated fatty acids, which had been shown previously to inhibit glucose-6-phosphatase in vitro.	Fatty Acids, Unsaturated	79-102	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	147-168
9405576-9	1997	Because the concentration of unsaturated fatty acids in both fractions quantitatively accounted for the inhibition of glucose-6 phosphatase observed, and because noninhibitory chromatographed glycogen reconstituted with equivalent amounts of pure unsaturated fatty acids inhibited the enzyme as glycogen did, we conclude that unsaturated fatty acids likely constitute the glycogen-associated compound that inhibits glucose-6 phosphatase activity.	Fatty Acids, Unsaturated	29-52	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	118-139
9368040-4	1997	At molar oxidant:HDL3 ratios >/= 60:1, we have observed pronounced consumption of HDL3 unsaturated fatty acids with concomitant formation of fatty acid chlorohydrins.	Fatty Acids, Unsaturated	90-113	high density lipoprotein (HDL) level 3	Mus musculus	85-89
9421194-1	1997	Polyunsaturated fatty acids (PUFA) repress stearoyl-CoA desaturase gene 1 (SCD1) expression in liver and adipose tissues.	Fatty Acids, Unsaturated	0-27	stearoyl-CoA desaturase	Homo sapiens	75-79
9421194-1	1997	Polyunsaturated fatty acids (PUFA) repress stearoyl-CoA desaturase gene 1 (SCD1) expression in liver and adipose tissues.	Fatty Acids, Unsaturated	29-33	stearoyl-CoA desaturase	Homo sapiens	75-79
9397406-3	1997	A fluorescent cis-parinaric acid displacement assay was used to show that SCP-2 optimally interacted with 14-22 carbon chain lipidic molecules: polyunsaturated fatty acids > monounsaturated, saturated > branched-chain isoprenoids > branched-chain phytol-derived fatty acids.	Fatty Acids, Unsaturated	144-171	sterol carrier protein 2	Homo sapiens	74-79
9397406-4	1997	In contrast, the other major fatty-acid binding protein in liver, fatty-acid binding protein (L-FABP), displayed a much narrower carbon chain preference in general: polyunsaturated fatty acids > branched-chain phytol-derived fatty acids > 14- and 16-carbon saturated > branched-chain isoprenoids.	Fatty Acids, Unsaturated	165-192	fatty acid binding protein 1	Homo sapiens	59-92
9397406-4	1997	In contrast, the other major fatty-acid binding protein in liver, fatty-acid binding protein (L-FABP), displayed a much narrower carbon chain preference in general: polyunsaturated fatty acids > branched-chain phytol-derived fatty acids > 14- and 16-carbon saturated > branched-chain isoprenoids.	Fatty Acids, Unsaturated	165-192	fatty acid binding protein 1	Homo sapiens	94-100
9397406-5	1997	However, both SCP-2 and L-FABP displayed a very similar unsaturated fatty-acid specificity profile.	Fatty Acids, Unsaturated	56-78	sterol carrier protein 2	Homo sapiens	14-19
9397406-5	1997	However, both SCP-2 and L-FABP displayed a very similar unsaturated fatty-acid specificity profile.	Fatty Acids, Unsaturated	56-78	fatty acid binding protein 1	Homo sapiens	24-30
9350068-1	1997	The effect of three different doses of n-3 polyunsaturated fatty acids (PUFA) on endothelin-1 (ET-1) was studied.	Fatty Acids, Unsaturated	72-76	endothelin 1	Homo sapiens	81-93
9341113-0	1997	Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha.	Fatty Acids, Unsaturated	0-26	fatty acid synthase	Mus musculus	50-69
9341113-0	1997	Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha.	Fatty Acids, Unsaturated	0-26	thyroid hormone responsive	Mus musculus	74-77
22062734-9	1997	The molar ratio of PUFA > 18:2 (polyunsaturated fatty acids with three or more double bonds) to alpha-tocopherol was significantly (p < 0.01) higher in thigh meat compared with breast meat, explaining the lower stability of the former during storage.	Fatty Acids, Unsaturated	35-62	pumilio RNA binding family member 3	Homo sapiens	19-23
9430388-5	1997	However, the situation is complicated by the fact that polyunsaturated fatty acids (PUFAs) oppose SFAs, i.e. PUFAs decrease LDL-C and increase LDL receptor (LDLr) activity, so the effect of SAT FAT intake may represent the combined influence of increased SFAs and decreased PUFAs.	Fatty Acids, Unsaturated	55-82	low density lipoprotein receptor	Homo sapiens	143-155
9430388-5	1997	However, the situation is complicated by the fact that polyunsaturated fatty acids (PUFAs) oppose SFAs, i.e. PUFAs decrease LDL-C and increase LDL receptor (LDLr) activity, so the effect of SAT FAT intake may represent the combined influence of increased SFAs and decreased PUFAs.	Fatty Acids, Unsaturated	55-82	low density lipoprotein receptor	Homo sapiens	157-161
9430388-5	1997	However, the situation is complicated by the fact that polyunsaturated fatty acids (PUFAs) oppose SFAs, i.e. PUFAs decrease LDL-C and increase LDL receptor (LDLr) activity, so the effect of SAT FAT intake may represent the combined influence of increased SFAs and decreased PUFAs.	Fatty Acids, Unsaturated	84-89	low density lipoprotein receptor	Homo sapiens	143-155
9430388-5	1997	However, the situation is complicated by the fact that polyunsaturated fatty acids (PUFAs) oppose SFAs, i.e. PUFAs decrease LDL-C and increase LDL receptor (LDLr) activity, so the effect of SAT FAT intake may represent the combined influence of increased SFAs and decreased PUFAs.	Fatty Acids, Unsaturated	84-89	low density lipoprotein receptor	Homo sapiens	157-161
9350068-1	1997	The effect of three different doses of n-3 polyunsaturated fatty acids (PUFA) on endothelin-1 (ET-1) was studied.	Fatty Acids, Unsaturated	72-76	endothelin 1	Homo sapiens	95-99
9302294-4	1997	These results extend the known chemistry of catalase-like proteins and reveal a distinct type of enzymatic construct involved in the metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	147-174	catalase	Homo sapiens	44-52
9294215-8	1997	These data suggest that the reactive groups of OxCL, such as aldehydes generated during the decomposition of oxidized polyunsaturated fatty acids, form covalent adducts with beta2GP1 (and other proteins) and that these are epitopes for aCLs.	Fatty Acids, Unsaturated	118-145	apolipoprotein H	Homo sapiens	174-182
9313156-6	1997	Medium-chain, long-chain, and unsaturated fatty acids in milk fat were increased by bST treatment.	Fatty Acids, Unsaturated	30-53	Weaning weight-maternal milk	Bos taurus	57-61
9280286-1	1997	Expression of the delta9- fatty acid desaturase gene, OLE1, of Saccharomyces cerevisiae is negatively regulated transcriptionally and post-transcriptionally by unsaturated fatty acids.	Fatty Acids, Unsaturated	160-183	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	54-58
9667857-3	1997	In addition, certain unsaturated fatty acids and eicosanoids were shown to bind the receptors, and thus represent naturally occurring PPAR ligands.	Fatty Acids, Unsaturated	21-44	peroxisome proliferator activated receptor alpha	Homo sapiens	134-138
9337873-12	1997	The activation by annexin VI of sPLA2 acting on red cell membranes results in the preferential release of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	106-133	phospholipase A2 group IIA	Homo sapiens	32-37
9337873-13	1997	It suggests that type II sPLA2, in conjunction with annexin VI, might be involved in the final step of endocytosis and/or exocytosis providing the free polyunsaturated fatty acids acting synergistically to cause membrane fusion.	Fatty Acids, Unsaturated	152-179	phospholipase A2 group IIA	Homo sapiens	25-30
9295158-0	1997	Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase.	Fatty Acids, Unsaturated	108-135	linoleate 9S-lipoxygenase-4	Glycine max	139-151
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Fatty Acids, Unsaturated	126-153	linoleate 9S-lipoxygenase-4	Glycine max	84-96
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Fatty Acids, Unsaturated	126-153	linoleate 9S-lipoxygenase-4	Glycine max	98-101
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Fatty Acids, Unsaturated	155-159	linoleate 9S-lipoxygenase-4	Glycine max	84-96
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Fatty Acids, Unsaturated	155-159	linoleate 9S-lipoxygenase-4	Glycine max	98-101
9295158-9	1997	For the oxidation of PUFA by LOX in the presence of beta-CD we propose a model in which free PUFA is the only effective substrate, thus the oxidation of the complexed substrate requires the previous dissociation of the complex.	Fatty Acids, Unsaturated	21-25	linoleate 9S-lipoxygenase-4	Glycine max	29-32
9295158-9	1997	For the oxidation of PUFA by LOX in the presence of beta-CD we propose a model in which free PUFA is the only effective substrate, thus the oxidation of the complexed substrate requires the previous dissociation of the complex.	Fatty Acids, Unsaturated	93-97	linoleate 9S-lipoxygenase-4	Glycine max	29-32
9266690-1	1997	We previously mapped the sequences responsive to insulin/glucose stimulation and polyunsaturated fatty-acid suppression in the proximal promoter region between positions -104 and -20 of the ATP citrate-lyase (ACL) gene [Fukuda, H., Iritani, N., Katsurada, A.	Fatty Acids, Unsaturated	81-107	ATP citrate lyase	Rattus norvegicus	190-207
20654323-4	1997	The unsaturated fatty acids increased both TEWL and LDV and elevated IL-1alpha and IL-8 mRNA levels, whereas their effects on protein levels were minimal.	Fatty Acids, Unsaturated	4-27	interleukin 1 alpha	Homo sapiens	69-78
20654323-4	1997	The unsaturated fatty acids increased both TEWL and LDV and elevated IL-1alpha and IL-8 mRNA levels, whereas their effects on protein levels were minimal.	Fatty Acids, Unsaturated	4-27	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
9266690-1	1997	We previously mapped the sequences responsive to insulin/glucose stimulation and polyunsaturated fatty-acid suppression in the proximal promoter region between positions -104 and -20 of the ATP citrate-lyase (ACL) gene [Fukuda, H., Iritani, N., Katsurada, A.	Fatty Acids, Unsaturated	81-107	ATP citrate lyase	Rattus norvegicus	209-212
9266690-10	1997	On the other hand, the formations of DNA-protein complexes with Sp1 binding site or ACL(-64 to -41) were decreased in rats fed a high-carbohydrate diet in comparison with those in rats fasted or fed a polyunsaturated fatty-acid-rich diet.	Fatty Acids, Unsaturated	201-227	ATP citrate lyase	Rattus norvegicus	84-87
9266690-12	1997	These results demonstrated that the region from -64 to -41 of the ACL gene was responsible for stimulation due to insulin/glucose, the stimulation was suppressed by polyunsaturated fatty acid, and Sp1 may be involved in the regulation.	Fatty Acids, Unsaturated	165-191	ATP citrate lyase	Rattus norvegicus	66-69
9250610-3	1997	The discovery of PPARs led us to hypothesize that polyunsaturated fatty acids coordinately modulated the transcription of lipogenic and oxidative genes via a PPAR mediated process.	Fatty Acids, Unsaturated	50-77	peroxisome proliferator activated receptor alpha	Rattus norvegicus	17-21
9241594-9	1997	Supplementation of the diet with an unsaturated fat source increased milk production and the proportion of unsaturated fatty acids in milk, but niacin supplementation had no substantial influence on milk production and only a minor influence on milk fatty acid content.	Fatty Acids, Unsaturated	107-130	Weaning weight-maternal milk	Bos taurus	134-138
9241594-9	1997	Supplementation of the diet with an unsaturated fat source increased milk production and the proportion of unsaturated fatty acids in milk, but niacin supplementation had no substantial influence on milk production and only a minor influence on milk fatty acid content.	Fatty Acids, Unsaturated	107-130	Weaning weight-maternal milk	Bos taurus	134-138
9241594-9	1997	Supplementation of the diet with an unsaturated fat source increased milk production and the proportion of unsaturated fatty acids in milk, but niacin supplementation had no substantial influence on milk production and only a minor influence on milk fatty acid content.	Fatty Acids, Unsaturated	107-130	Weaning weight-maternal milk	Bos taurus	134-138
9312933-6	1997	ApoA-1 transports transports polyunsaturated fatty acids directly to cells including hepatocytes.	Fatty Acids, Unsaturated	29-56	apolipoprotein A1	Homo sapiens	0-6
9312933-9	1997	For the structural function polyunsaturated fatty acids are transported by ApoA-1 high density lipoproteins in the polar phase and they penetrate into cells via phospholipid re-esterification.	Fatty Acids, Unsaturated	28-55	apolipoprotein A1	Homo sapiens	75-81
9219729-3	1997	The omega3 polyunsaturated fatty acid (PUFA)-rich diets (LIN and POL) elicited more metastases than the omega6 PUFA-rich (SAF), fat-free (TEK), or saturated fats (BT) diets.	Fatty Acids, Unsaturated	39-43	predicted gene, 42368	Mus musculus	65-68
9254057-1	1997	In the monocytic THP-1 cells, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor simvastatin (5 microM) enhances the conversion of exogenous linoleic (18:2 n-6) and eicosapentaenoic (20:5 n-3) acids to their long-chain polyunsaturated fatty acid (LC-PUFA) derivatives, and this effect is associated with changes in the desaturation steps.	Fatty Acids, Unsaturated	240-266	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	34-91
9169410-9	1997	It is proposed that elevated production of reactive oxygen intermediates by cells expressing CYP2E1 can cause lipid peroxidation, which subsequently promotes apoptosis and cell toxicity when the cells are enriched with polyunsaturated fatty acids such as arachidonic acid.	Fatty Acids, Unsaturated	219-246	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	93-99
9187620-0	1997	Dietary soybean protein increases insulin receptor gene expression in Wistar fatty rats when dietary polyunsaturated fatty acid level is low.	Fatty Acids, Unsaturated	101-127	insulin receptor	Rattus norvegicus	34-50
9227328-0	1997	Activation of neutral sphingomyelinase in human neutrophils by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	63-90	sphingomyelin phosphodiesterase 2	Homo sapiens	14-38
9157941-4	1997	Linoleic acid, which is the most abundant polyunsaturated fatty acid, was negatively associated with plasminogen and fibrinogen.	Fatty Acids, Unsaturated	42-68	fibrinogen beta chain	Homo sapiens	117-127
9215538-6	1997	PC species containing long chain, polyunsaturated fatty acids (PUFA) in the sn-2 position resulted in increased binding affinity (Kd = 75-177 nM) but reduced capacity (0.1-0.3 apoA-I/ 1000 PC) in comparison to sn-1 palmitoyl, sn-2 oleoyl PC (POPC, 750 nM and 1.4 apoA-I/1000 PC).	Fatty Acids, Unsaturated	34-61	apolipoprotein A1	Homo sapiens	176-182
9215538-6	1997	PC species containing long chain, polyunsaturated fatty acids (PUFA) in the sn-2 position resulted in increased binding affinity (Kd = 75-177 nM) but reduced capacity (0.1-0.3 apoA-I/ 1000 PC) in comparison to sn-1 palmitoyl, sn-2 oleoyl PC (POPC, 750 nM and 1.4 apoA-I/1000 PC).	Fatty Acids, Unsaturated	34-61	apolipoprotein A1	Homo sapiens	263-269
9215538-6	1997	PC species containing long chain, polyunsaturated fatty acids (PUFA) in the sn-2 position resulted in increased binding affinity (Kd = 75-177 nM) but reduced capacity (0.1-0.3 apoA-I/ 1000 PC) in comparison to sn-1 palmitoyl, sn-2 oleoyl PC (POPC, 750 nM and 1.4 apoA-I/1000 PC).	Fatty Acids, Unsaturated	63-67	apolipoprotein A1	Homo sapiens	176-182
9215538-6	1997	PC species containing long chain, polyunsaturated fatty acids (PUFA) in the sn-2 position resulted in increased binding affinity (Kd = 75-177 nM) but reduced capacity (0.1-0.3 apoA-I/ 1000 PC) in comparison to sn-1 palmitoyl, sn-2 oleoyl PC (POPC, 750 nM and 1.4 apoA-I/1000 PC).	Fatty Acids, Unsaturated	63-67	apolipoprotein A1	Homo sapiens	263-269
9099683-14	1997	DGKtheta activity in COS cell lysates is optimal toward diacylglycerols containing an unsaturated fatty acid at the sn-2 position.	Fatty Acids, Unsaturated	86-108	diacylglycerol kinase theta	Homo sapiens	0-8
9181465-1	1997	The objective of this study was to investigate the impact of feeding mice a diet rich in n-3 polyunsaturated fatty acids (PUFA) from fish oil on the interferon-gamma (IFN-gamma) response during an active infection with Listeria monocytogenes.	Fatty Acids, Unsaturated	122-126	interferon gamma	Mus musculus	167-176
9065785-1	1997	Growth of the murine B-lymphocyte cell line CC9C10 and the myeloma SP2/0 was enhanced significantly by the presence of the unsaturated fatty acids, oleic and linoleic acids in serum-free culture.	Fatty Acids, Unsaturated	123-146	Sp2 transcription factor	Mus musculus	67-72
9092545-6	1997	PAK-2/PRK2 was also activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids.	Fatty Acids, Unsaturated	123-146	p21 (RAC1) activated kinase 2	Rattus norvegicus	0-5
9092545-6	1997	PAK-2/PRK2 was also activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids.	Fatty Acids, Unsaturated	123-146	protein kinase N2	Homo sapiens	6-10
9126322-2	1997	Here we report that 1-hydroxy-2-oxo-3,3-bis(3-aminoethyl)-1-triazene (NOC-18), a compound which releases NO at low rate in aqueous solutions, powerfully inhibits the peroxidation of polyunsaturated fatty acids, tryptophan loss, the formation of fluorescent aldehydic adducts in apo B100 and the increase of electrophoretic mobility in isolated LDL undergoing oxidation.	Fatty Acids, Unsaturated	182-209	apolipoprotein B	Homo sapiens	278-286
9136894-1	1997	We previously mapped the sequences responsive to insulin/glucose stimulation and polyunsaturated fatty acid (PUFA) suppression in proximal promoter region from -57 to -35 of fatty acid synthase (FAS) gene of rat liver [Fukuda et al.	Fatty Acids, Unsaturated	81-107	fatty acid synthase	Rattus norvegicus	174-193
9136894-1	1997	We previously mapped the sequences responsive to insulin/glucose stimulation and polyunsaturated fatty acid (PUFA) suppression in proximal promoter region from -57 to -35 of fatty acid synthase (FAS) gene of rat liver [Fukuda et al.	Fatty Acids, Unsaturated	81-107	fatty acid synthase	Rattus norvegicus	195-198
9136894-1	1997	We previously mapped the sequences responsive to insulin/glucose stimulation and polyunsaturated fatty acid (PUFA) suppression in proximal promoter region from -57 to -35 of fatty acid synthase (FAS) gene of rat liver [Fukuda et al.	Fatty Acids, Unsaturated	109-113	fatty acid synthase	Rattus norvegicus	174-193
9136894-1	1997	We previously mapped the sequences responsive to insulin/glucose stimulation and polyunsaturated fatty acid (PUFA) suppression in proximal promoter region from -57 to -35 of fatty acid synthase (FAS) gene of rat liver [Fukuda et al.	Fatty Acids, Unsaturated	109-113	fatty acid synthase	Rattus norvegicus	195-198
9083074-0	1997	A heterocomplex formed by the calcium-binding proteins MRP8 (S100A8) and MRP14 (S100A9) binds unsaturated fatty acids with high affinity.	Fatty Acids, Unsaturated	94-117	S100 calcium binding protein A8	Homo sapiens	55-59
9083074-0	1997	A heterocomplex formed by the calcium-binding proteins MRP8 (S100A8) and MRP14 (S100A9) binds unsaturated fatty acids with high affinity.	Fatty Acids, Unsaturated	94-117	S100 calcium binding protein A8	Homo sapiens	61-67
9083074-0	1997	A heterocomplex formed by the calcium-binding proteins MRP8 (S100A8) and MRP14 (S100A9) binds unsaturated fatty acids with high affinity.	Fatty Acids, Unsaturated	94-117	S100 calcium binding protein A9	Homo sapiens	73-78
9083074-0	1997	A heterocomplex formed by the calcium-binding proteins MRP8 (S100A8) and MRP14 (S100A9) binds unsaturated fatty acids with high affinity.	Fatty Acids, Unsaturated	94-117	S100 calcium binding protein A9	Homo sapiens	80-86
9083074-1	1997	We show that unsaturated fatty acids (FAs) bind reversibly and with high affinity to a heterocomplex of 34 kDa (FA-p34) formed by the non-covalent association of two calcium-binding proteins of the S100 family: MRP8 (S100A8) and MRP14 (S100A9).	Fatty Acids, Unsaturated	13-36	alpha and gamma adaptin binding protein	Homo sapiens	115-118
9083074-1	1997	We show that unsaturated fatty acids (FAs) bind reversibly and with high affinity to a heterocomplex of 34 kDa (FA-p34) formed by the non-covalent association of two calcium-binding proteins of the S100 family: MRP8 (S100A8) and MRP14 (S100A9).	Fatty Acids, Unsaturated	13-36	S100 calcium binding protein A8	Homo sapiens	211-215
9083074-1	1997	We show that unsaturated fatty acids (FAs) bind reversibly and with high affinity to a heterocomplex of 34 kDa (FA-p34) formed by the non-covalent association of two calcium-binding proteins of the S100 family: MRP8 (S100A8) and MRP14 (S100A9).	Fatty Acids, Unsaturated	13-36	S100 calcium binding protein A8	Homo sapiens	217-223
9083074-1	1997	We show that unsaturated fatty acids (FAs) bind reversibly and with high affinity to a heterocomplex of 34 kDa (FA-p34) formed by the non-covalent association of two calcium-binding proteins of the S100 family: MRP8 (S100A8) and MRP14 (S100A9).	Fatty Acids, Unsaturated	13-36	S100 calcium binding protein A9	Homo sapiens	229-234
9083074-1	1997	We show that unsaturated fatty acids (FAs) bind reversibly and with high affinity to a heterocomplex of 34 kDa (FA-p34) formed by the non-covalent association of two calcium-binding proteins of the S100 family: MRP8 (S100A8) and MRP14 (S100A9).	Fatty Acids, Unsaturated	13-36	S100 calcium binding protein A9	Homo sapiens	236-242
9083074-7	1997	In abnormally differentiated keratinocytes (psoriasis) and in human polymorphonuclear leukocytes, FA-p34 is highly expressed (31.35 +/- 1.6 and 349.8 +/- 17.9 pmol of [3H]oleic acid/mg protein, respectively), pointing toward a role for this heteromer in mediating effects of unsaturated fatty acids in a calcium-dependent way during cell differentiation and/or inflammation.	Fatty Acids, Unsaturated	275-298	alpha and gamma adaptin binding protein	Homo sapiens	101-104
9215062-5	1997	CONCLUSIONS: Dense labelling for acidic GST could be linked with the previously documented presence of large quantities of polyunsaturated fatty acids in the iris and/or the presence of xenobiotic substances in the aqueous humour.	Fatty Acids, Unsaturated	123-150	glutathione S-transferase kappa 1	Homo sapiens	40-43
9085017-6	1997	With respect to fat quality, particular attention is currently directed at the optimal content of polyunsaturated fatty acids and their long-chain metabolites (LC-PUFA).	Fatty Acids, Unsaturated	98-125	pumilio RNA binding family member 3	Homo sapiens	163-167
9410415-9	1997	The mentioned data indicate that the decrease of polyunsaturated fatty acids (esp.	Fatty Acids, Unsaturated	49-76	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	78-81
9162746-5	1997	The activation energy of LCAT was lower for rHDL containing long chain polyunsaturated fatty acids (PUFA) compared to rHDL containing 100% POPC or 10% PC/90% OPPC ether.	Fatty Acids, Unsaturated	71-98	lecithin-cholesterol acyltransferase	Homo sapiens	25-29
9162746-5	1997	The activation energy of LCAT was lower for rHDL containing long chain polyunsaturated fatty acids (PUFA) compared to rHDL containing 100% POPC or 10% PC/90% OPPC ether.	Fatty Acids, Unsaturated	100-104	lecithin-cholesterol acyltransferase	Homo sapiens	25-29
9000529-0	1997	Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain.	Fatty Acids, Unsaturated	77-104	protein phosphatase 5 catalytic subunit	Homo sapiens	14-35
9000529-3	1997	Polyunsaturated fatty acids, such as arachidonic acid, and lipids containing polyunsaturated fatty acids, such as phosphatidylinositol, stimulate both bacterially expressed human and native rabbit PP5 activity > 25-fold towards casein and myelin basic protein.	Fatty Acids, Unsaturated	0-27	protein phosphatase 5 catalytic subunit	Homo sapiens	197-200
9000529-3	1997	Polyunsaturated fatty acids, such as arachidonic acid, and lipids containing polyunsaturated fatty acids, such as phosphatidylinositol, stimulate both bacterially expressed human and native rabbit PP5 activity > 25-fold towards casein and myelin basic protein.	Fatty Acids, Unsaturated	0-27	myelin basic protein	Oryctolagus cuniculus	242-262
9000529-3	1997	Polyunsaturated fatty acids, such as arachidonic acid, and lipids containing polyunsaturated fatty acids, such as phosphatidylinositol, stimulate both bacterially expressed human and native rabbit PP5 activity > 25-fold towards casein and myelin basic protein.	Fatty Acids, Unsaturated	77-104	protein phosphatase 5 catalytic subunit	Homo sapiens	197-200
9547608-3	1997	In this study, we have examined the effects of polyunsaturated fatty acids (PUFAs) on the production of IL-6 by human unstimulated EC or EC stimulated with TNF-alpha (100 U/ml); IL-4 (100 U/ml); LPS (1 ug/ml); or allogeneic peripheral blood lymphocytes (PBL).	Fatty Acids, Unsaturated	47-74	interleukin 6	Homo sapiens	104-108
9547608-3	1997	In this study, we have examined the effects of polyunsaturated fatty acids (PUFAs) on the production of IL-6 by human unstimulated EC or EC stimulated with TNF-alpha (100 U/ml); IL-4 (100 U/ml); LPS (1 ug/ml); or allogeneic peripheral blood lymphocytes (PBL).	Fatty Acids, Unsaturated	76-81	interleukin 6	Homo sapiens	104-108
9547608-3	1997	In this study, we have examined the effects of polyunsaturated fatty acids (PUFAs) on the production of IL-6 by human unstimulated EC or EC stimulated with TNF-alpha (100 U/ml); IL-4 (100 U/ml); LPS (1 ug/ml); or allogeneic peripheral blood lymphocytes (PBL).	Fatty Acids, Unsaturated	76-81	tumor necrosis factor	Homo sapiens	156-165
9285250-3	1997	The objectives of this review are two fold: to examine the data on the long chain polyunsaturated fatty acid levels (LC-PUFA) in human milk and the rationale for inclusion of these lipids in infant formulas; secondly, as a consequence of addition of highly unsaturated lipids to infant formulas, the antioxidant requirements are increased.	Fatty Acids, Unsaturated	82-108	pumilio RNA binding family member 3	Homo sapiens	120-124
9266513-6	1997	Previous studies described the enhanced sensitivity of the Q-deficient yeast strain containing a deletion in the COQ3 gene to the products of autoxidized polyunsaturated fatty acids (Do et al., 1996, Proceeding of the National Academy of Science USA, 93, 7534-7539).	Fatty Acids, Unsaturated	154-181	hexaprenyldihydroxybenzoate methyltransferase	Saccharomyces cerevisiae S288C	113-117
9055409-3	1997	In this study, ATF1 gene expression was studied by Northern analysis, and the results showed that the ATF1 gene was repressed both by aeration and by unsaturated fatty acids.	Fatty Acids, Unsaturated	150-173	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	15-19
9055409-3	1997	In this study, ATF1 gene expression was studied by Northern analysis, and the results showed that the ATF1 gene was repressed both by aeration and by unsaturated fatty acids.	Fatty Acids, Unsaturated	150-173	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	102-106
8982278-1	1996	Unsaturated fatty acids of odd carbons, 13:1(12), 17:1(10trans), 19:1(7) and 19:1(10) inhibited release of myeloperoxidase (MPO) from fMet-Leu-Phe-cytochalasin B-treated neutrophils.	Fatty Acids, Unsaturated	0-23	myeloperoxidase	Homo sapiens	107-122
8979262-0	1996	The relationship between altered membrane composition, eicosanoids and TNF-induced IL1 and IL6 production in macrophages of rats fed fats of different unsaturated fatty acid composition.	Fatty Acids, Unsaturated	151-173	tumor necrosis factor	Rattus norvegicus	71-74
8982278-1	1996	Unsaturated fatty acids of odd carbons, 13:1(12), 17:1(10trans), 19:1(7) and 19:1(10) inhibited release of myeloperoxidase (MPO) from fMet-Leu-Phe-cytochalasin B-treated neutrophils.	Fatty Acids, Unsaturated	0-23	myeloperoxidase	Homo sapiens	124-127
8933307-8	1996	Thus, the long-chain polyunsaturated fatty acids in MFGM constituted approximately 40-70 g/kg total milk fat.	Fatty Acids, Unsaturated	21-48	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	52-56
8953702-0	1996	Polyunsaturated fatty acid biosynthesis in Saccharomyces cerevisiae: expression of ethanol tolerance and the FAD2 gene from Arabidopsis thaliana.	Fatty Acids, Unsaturated	0-26	fatty acid desaturase 2	Arabidopsis thaliana	109-113
8953702-5	1996	A marked effect on the unsaturation of 16:1 and 18:1 was observed when S. cerevisiae harboring the FAD2 gene was cultured at 8 degrees C. To assess the ethanol tolerance of S. cerevisiae producing polyunsaturated fatty acids, the cell viability of this strain in the presence of ethanol was examined.	Fatty Acids, Unsaturated	197-224	fatty acid desaturase 2	Arabidopsis thaliana	99-103
8939925-0	1996	Regulation of stearoyl-CoA desaturase 1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocytes.	Fatty Acids, Unsaturated	58-85	stearoyl-CoA desaturase	Homo sapiens	14-37
8939925-6	1996	Taken together, these results suggest that polyunsaturated fatty acids repress the expression of the scd1 gene in mature adipocytes by reducing the stability of scd1 mRNA.	Fatty Acids, Unsaturated	43-70	stearoyl-CoA desaturase	Homo sapiens	101-105
8939925-6	1996	Taken together, these results suggest that polyunsaturated fatty acids repress the expression of the scd1 gene in mature adipocytes by reducing the stability of scd1 mRNA.	Fatty Acids, Unsaturated	43-70	stearoyl-CoA desaturase	Homo sapiens	161-165
8961160-4	1996	These permeation-enhancing effects by unsaturated fatty acids were affected by changes of their alkyl chain length from C14 to C22.	Fatty Acids, Unsaturated	38-61	anti-Mullerian hormone receptor type 2	Rattus norvegicus	120-123
8961160-5	1996	The lag-times on the permeation of indomethacin were shortened by unsaturated fatty acids in the following order: C20 = C18 = C22 < C16 < C14.	Fatty Acids, Unsaturated	66-89	anti-Mullerian hormone receptor type 2	Rattus norvegicus	144-147
8961160-6	1996	These fluxes were increased by unsaturated fatty acids in the following order: C20 > C22 = C18 = C16 > C14.	Fatty Acids, Unsaturated	31-54	anti-Mullerian hormone receptor type 2	Rattus norvegicus	109-112
8901621-0	1996	Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons.	Fatty Acids, Unsaturated	0-27	carbonic anhydrase 1	Rattus norvegicus	68-71
8824209-1	1996	Unsaturated fatty acid-induced degradation of the Saccharomyces OLE1 transcript.	Fatty Acids, Unsaturated	0-22	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	64-68
8824209-2	1996	The Saccharomyces cerevisiae OLE1 gene encodes the Delta-9 fatty acid desaturase, a highly regulated integral membrane enzyme involved in the formation of unsaturated fatty acids from saturated acyl-coenzyme A precursors.	Fatty Acids, Unsaturated	155-178	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	29-33
8824209-4	1996	One involves the unsaturated fatty acid repression of OLE1 transcription; the second, described in this report, involves unsaturated fatty acid-responsive changes in the half-life of the OLE1 mRNA.	Fatty Acids, Unsaturated	17-39	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	54-58
8824209-4	1996	One involves the unsaturated fatty acid repression of OLE1 transcription; the second, described in this report, involves unsaturated fatty acid-responsive changes in the half-life of the OLE1 mRNA.	Fatty Acids, Unsaturated	121-143	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	187-191
8798739-6	1996	These and other experiments establish that BLBP has a strong preference for binding long chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	95-122	fatty acid binding protein 7	Homo sapiens	43-47
9100355-1	1996	To check the proposed hypothesis that the relative content of individual polyunsaturated fatty acids (PUFAs)--substrates and inhibitors of prostanoid synthesis--in plasma can be regarded as a quantitative risk factor of blood clotting, a test was conducted on free fatty acids content in blood plasma of healthy people (group 0) and patients with heart ischemia before (group 1) and after (group 2) they were treated for a month with a food additive called "Eiconol," enriched with PUFA omega 3.	Fatty Acids, Unsaturated	73-100	pumilio RNA binding family member 3	Homo sapiens	102-106
8790349-13	1996	Our data show that hepatic SCD1 gene expression is regulated by PPARs and suggest that peroxisome proliferators and poly-unsaturated fatty acids act through distinct mechanisms.	Fatty Acids, Unsaturated	116-144	stearoyl-Coenzyme A desaturase 1	Mus musculus	27-31
8663275-1	1996	Evidence against the peroxisome proliferator-activated receptor alpha as the mediator of polyunsaturated fatty acid regulation of s14 gene transcription.	Fatty Acids, Unsaturated	89-115	peroxisome proliferator activated receptor alpha	Rattus norvegicus	21-69
8878171-11	1996	These findings were confirmed in feeding experiments, in which rs was reduced and CD44 capping increased by polyunsaturated fatty acid diets.	Fatty Acids, Unsaturated	108-134	CD44 antigen	Mus musculus	82-86
8931115-7	1996	In contrast to the cell proliferation, uPA production was inhibited by all the unsaturated fatty acids under investigation.	Fatty Acids, Unsaturated	79-102	plasminogen activator, urokinase	Homo sapiens	39-42
8702792-4	1996	The composition of fatty acids associated with IRBP in bovine retina was determined, and it was found that polyunsaturated fatty acids constitute a significant fraction of those.	Fatty Acids, Unsaturated	107-134	retinol binding protein 3	Bos taurus	47-51
8755509-9	1996	As a result of polyunsaturated fatty acid treatment, there is a marked elevation of lipid hydroperoxides in the coq3 mutant as compared with either wild-type or respiratory-deficient control strains.	Fatty Acids, Unsaturated	15-41	hexaprenyldihydroxybenzoate methyltransferase	Saccharomyces cerevisiae S288C	112-116
8760080-0	1996	Adipose tissue stearoyl-CoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	85-112	stearoyl-CoA desaturase	Rattus norvegicus	15-38
8663269-6	1996	The purified ACS3 utilizes laurate and myristate most efficiently among C8-C22 saturated fatty acids and arachidonate and eicosapentaenoate among C16-C20 unsaturated fatty acids.	Fatty Acids, Unsaturated	154-177	acyl-CoA synthetase long-chain family member 3	Rattus norvegicus	13-17
8760080-1	1996	Stearoyl-CoA desaturase (SCD) is a key regulatory enzyme in the synthesis of unsaturated fatty acids.	Fatty Acids, Unsaturated	77-100	stearoyl-CoA desaturase	Rattus norvegicus	0-23
8760080-1	1996	Stearoyl-CoA desaturase (SCD) is a key regulatory enzyme in the synthesis of unsaturated fatty acids.	Fatty Acids, Unsaturated	77-100	stearoyl-CoA desaturase	Rattus norvegicus	25-28
8760080-2	1996	Although regulation of hepatic SCD by obesity and polyunsaturated fatty acids (PUFA) has been well investigated, no studies have addressed whether similar regulation occurs in adipose tissue.	Fatty Acids, Unsaturated	50-77	stearoyl-CoA desaturase	Rattus norvegicus	31-34
8760080-2	1996	Although regulation of hepatic SCD by obesity and polyunsaturated fatty acids (PUFA) has been well investigated, no studies have addressed whether similar regulation occurs in adipose tissue.	Fatty Acids, Unsaturated	79-83	stearoyl-CoA desaturase	Rattus norvegicus	31-34
8872718-8	1996	Milk fat from cows fed soybeans or sunflower seeds contained higher concentrations of unsaturated fatty acids and long-chain fatty acids than did milk fat from cows fed the control diet.	Fatty Acids, Unsaturated	86-109	Weaning weight-maternal milk	Bos taurus	0-4
8872718-10	1996	Soybeans or sunflower seeds can be used as dietary fat supplements to increase milk yield and the proportion of unsaturated fatty acids in milk fat.	Fatty Acids, Unsaturated	112-135	Weaning weight-maternal milk	Bos taurus	139-143
8663012-11	1996	Synthetic PS with two unsaturated fatty acids, such as 1,2-dioleoyl-PS or 1,2-dilinoleoyl-PS, showed the same effect toward the Ki-Ras- and Rap1B-stimulated B-Raf activities, but synthetic PS with two saturated fatty acids, such as 1, 2-distearoyl-PS, was inactive.	Fatty Acids, Unsaturated	22-45	ras-related protein Rap-1b	Bos taurus	140-145
8663012-11	1996	Synthetic PS with two unsaturated fatty acids, such as 1,2-dioleoyl-PS or 1,2-dilinoleoyl-PS, showed the same effect toward the Ki-Ras- and Rap1B-stimulated B-Raf activities, but synthetic PS with two saturated fatty acids, such as 1, 2-distearoyl-PS, was inactive.	Fatty Acids, Unsaturated	22-45	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	157-162
8650253-8	1996	Results from a previous study demonstrated that VIT E stimulated bone formation in chicks fed unsaturated fat, and the present findings in cultures of epiphyseal chondrocytes suggest that VIT E is important for chondrocyte function in the presence of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	251-278	vitrin	Homo sapiens	188-191
8632982-1	1996	Addition of a saturated fatty acid (SFA) induced a strong increase in heat shock (HS) mRNA transcription when cells were heat-shocked at 37 degrees C, whereas treatment with an unsaturated fatty acid (UFA) reduced or eliminated the level of HS gene transcription at 37 degrees C. Transcription of the delta 9-desaturase gene (Ole1) of Histoplasma capsulatum, whose gene product is responsible for the synthesis of UFA, is up-regulated in a temperature-sensitive strain.	Fatty Acids, Unsaturated	177-199	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	326-330
8888356-7	1996	Similarly, a significant inhibitory effect by n-3 PUFA treatment on basal and LPS-stimulated IL-6 monocyte production was observed (50% and 46%, respectively, P < 0.05).	Fatty Acids, Unsaturated	50-54	interleukin 6	Homo sapiens	93-97
8632982-1	1996	Addition of a saturated fatty acid (SFA) induced a strong increase in heat shock (HS) mRNA transcription when cells were heat-shocked at 37 degrees C, whereas treatment with an unsaturated fatty acid (UFA) reduced or eliminated the level of HS gene transcription at 37 degrees C. Transcription of the delta 9-desaturase gene (Ole1) of Histoplasma capsulatum, whose gene product is responsible for the synthesis of UFA, is up-regulated in a temperature-sensitive strain.	Fatty Acids, Unsaturated	201-204	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	326-330
9132168-0	1996	Insulin/glucose-, pyruvate- and polyunsaturated fatty acid-responsive region(s) of rat fatty acid synthase gene promoter.	Fatty Acids, Unsaturated	32-58	fatty acid synthase	Rattus norvegicus	87-106
8824209-10	1996	A chimeric mRNA, produced by replacing the upstream activation and fatty acid-regulated regions of the OLE1 promoter with the GAL1 promoter sequences is destabilized by exogenous unsaturated fatty acids.	Fatty Acids, Unsaturated	179-202	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	103-107
8824209-10	1996	A chimeric mRNA, produced by replacing the upstream activation and fatty acid-regulated regions of the OLE1 promoter with the GAL1 promoter sequences is destabilized by exogenous unsaturated fatty acids.	Fatty Acids, Unsaturated	179-202	galactokinase	Saccharomyces cerevisiae S288C	126-130
8824209-14	1996	Its half-life is reduced when those cells are exposed to unsaturated fatty acids, indicating that the 5"-exoribonuclease encoded by the XRN1 gene is required for the rapid degradation of the OLE1 transcript but is not required for fatty acid-induced destabilization.	Fatty Acids, Unsaturated	57-80	chromatin-binding exonuclease XRN1	Saccharomyces cerevisiae S288C	136-140
8642441-1	1996	Polyunsaturated fatty acids (PUFA) modulate the rate of gene transcription for a number of different genes including hepatic lipogenic and glycolytic genes, adipose Glut-4 and stearoyl-CoA desaturase and interleukins.	Fatty Acids, Unsaturated	0-27	stearoyl-CoA desaturase	Homo sapiens	176-199
8642441-1	1996	Polyunsaturated fatty acids (PUFA) modulate the rate of gene transcription for a number of different genes including hepatic lipogenic and glycolytic genes, adipose Glut-4 and stearoyl-CoA desaturase and interleukins.	Fatty Acids, Unsaturated	29-33	stearoyl-CoA desaturase	Homo sapiens	176-199
8729090-0	1996	Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice.	Fatty Acids, Unsaturated	0-27	stearoyl-Coenzyme A desaturase 1	Mus musculus	44-69
27405950-6	1996	Increased oxidative stress in CCl4 treated rats was indicated by a significant decrease of liver ascorbate and a decrease in the plasma ratio of polyunsaturated fatty acids (PUFA) to total free fatty acids.	Fatty Acids, Unsaturated	145-172	C-C motif chemokine ligand 4	Rattus norvegicus	30-34
27405950-6	1996	Increased oxidative stress in CCl4 treated rats was indicated by a significant decrease of liver ascorbate and a decrease in the plasma ratio of polyunsaturated fatty acids (PUFA) to total free fatty acids.	Fatty Acids, Unsaturated	174-178	C-C motif chemokine ligand 4	Rattus norvegicus	30-34
8701605-6	1996	POX1 has been shown to be transcriptionally activated in the presence of unsaturated fatty acids.	Fatty Acids, Unsaturated	73-96	acyl-CoA oxidase	Saccharomyces cerevisiae S288C	0-4
8607881-1	1996	Insulin and polyunsaturated fatty acids (PUFAs) regulate the expression of SCD1 gene in mouse liver.	Fatty Acids, Unsaturated	12-39	stearoyl-Coenzyme A desaturase 1	Mus musculus	75-79
8607881-1	1996	Insulin and polyunsaturated fatty acids (PUFAs) regulate the expression of SCD1 gene in mouse liver.	Fatty Acids, Unsaturated	41-46	stearoyl-Coenzyme A desaturase 1	Mus musculus	75-79
8619607-2	1996	Hypochlorous acid, which is also generated by MPO, reacts with unsaturated fatty acids to form chlorohydrins.	Fatty Acids, Unsaturated	63-86	myeloperoxidase	Homo sapiens	46-49
8729087-1	1996	Polyunsaturated fatty acids (PUFA) of the n-6 and n-3 families inhibit transcription of a number of hepatic lipogenic and glycolytic genes, e.g. fatty acid synthase.	Fatty Acids, Unsaturated	0-27	fatty acid synthase	Homo sapiens	145-164
8729087-1	1996	Polyunsaturated fatty acids (PUFA) of the n-6 and n-3 families inhibit transcription of a number of hepatic lipogenic and glycolytic genes, e.g. fatty acid synthase.	Fatty Acids, Unsaturated	29-33	fatty acid synthase	Homo sapiens	145-164
8678919-4	1996	With unsaturated fatty acids, apo B containing lipoproteins were secreted at chylomicron/VLDL density (d < 1.006 g/ml).	Fatty Acids, Unsaturated	5-28	apolipoprotein B	Homo sapiens	30-35
8678919-10	1996	In conclusion, unsaturated fatty acids were most potent in stimulating the secretion of apo B by specifically increasing apo B-48 secretion.	Fatty Acids, Unsaturated	15-38	apolipoprotein B	Homo sapiens	88-93
8678919-10	1996	In conclusion, unsaturated fatty acids were most potent in stimulating the secretion of apo B by specifically increasing apo B-48 secretion.	Fatty Acids, Unsaturated	15-38	apolipoprotein B	Homo sapiens	121-126
8729130-3	1996	Work in vitro and in vivo in both rats and humans has shown that incorporation of more unsaturated fatty acids into muscle membrane phospholipid is associated with improved insulin action.	Fatty Acids, Unsaturated	87-110	insulin	Homo sapiens	173-180
8729130-7	1996	In relation to fiber type, the more highly oxidative, insulin-sensitive type 1 and type 2a fibers have a higher percentage of unsaturated fatty acids, particularly n-3, in their membrane phospholipid, compared to the insulin-resistant, glycolytic, type 2b fibers.	Fatty Acids, Unsaturated	126-149	insulin	Homo sapiens	54-61
8729091-1	1996	Effects of polyunsaturated fatty acids on expression of early-response genes c-fos and Egr-1 and induction of cell growth were assessed in Swiss 3T3 fibroblasts.	Fatty Acids, Unsaturated	11-38	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-82
8729091-1	1996	Effects of polyunsaturated fatty acids on expression of early-response genes c-fos and Egr-1 and induction of cell growth were assessed in Swiss 3T3 fibroblasts.	Fatty Acids, Unsaturated	11-38	early growth response 1	Homo sapiens	87-92
8603738-0	1996	Insulin- and polyunsaturated fatty acid-responsive region(s) of rat ATP citrate lyase gene promoter.	Fatty Acids, Unsaturated	13-39	ATP citrate lyase	Rattus norvegicus	68-85
8602457-3	1996	This inhibitory effect is PUFA dose-dependent and seems to be more potent with DHA than EPA, Pre-incubation experiments showed that lymphocytes cultured with PUFAs for 6 h then washed and exposed to PHA, still inhibited lymphocyte proliferation.	Fatty Acids, Unsaturated	158-163	pumilio RNA binding family member 3	Homo sapiens	26-30
8597582-1	1996	The objective of this experiment was to determine the effect of polyunsaturated fatty acids on gene expression for fatty acid synthase, acetyl CoA-carboxylase, malic enzyme, pyruvate kinase, and phosphoenolpyruvate carboxykinase in obese mice.	Fatty Acids, Unsaturated	64-91	fatty acid synthase	Mus musculus	115-134
8597582-7	1996	The decrease in liver fatty acid synthase mRNA level was more pronounced in lean mice compared to obese mice, suggesting that the obese mice may be more resistant to polyunsaturated fatty acid feedback control of gene expression.	Fatty Acids, Unsaturated	166-192	fatty acid synthase	Mus musculus	22-41
8851173-5	1996	The protective effects of the polyunsaturated fatty acids (PUFA) could be reversed by cell perfusion with delipidated bovine serum albumin.	Fatty Acids, Unsaturated	30-57	albumin	Rattus norvegicus	125-138
8851173-5	1996	The protective effects of the polyunsaturated fatty acids (PUFA) could be reversed by cell perfusion with delipidated bovine serum albumin.	Fatty Acids, Unsaturated	59-63	albumin	Rattus norvegicus	125-138
8631965-0	1996	Regulatory elements that control transcription activation and unsaturated fatty acid-mediated repression of the Saccharomyces cerevisiae OLE1 gene.	Fatty Acids, Unsaturated	62-84	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	137-141
8631965-1	1996	In Saccharomyces cerevisiae, unsaturated fatty acids are formed from saturated acyl-CoA precursors by Ole1p, a delta-9 fatty acid desaturase.	Fatty Acids, Unsaturated	29-52	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	102-107
8631965-4	1996	Saturated fatty acids induce a 1.6-fold increase in transcription activity, whereas a large family of unsaturated fatty acids repress OLE1 transcription as much as 60-fold.	Fatty Acids, Unsaturated	102-125	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	134-138
8631965-5	1996	A deletion analysis of OLE1 promoter::lacZ fusion reporter genes identified a 111-base pair (bp) fatty acid-regulated (FAR) region approximately 580 bp upstream of the start codon that is essential for transcription activation and unsaturated fatty acid repression.	Fatty Acids, Unsaturated	231-253	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	23-27
8631965-7	1996	The 111-bp FAR element strongly activates transcription and confers unsaturated fatty acid regulation on a heterologous CYC1 promoter test plasmid.	Fatty Acids, Unsaturated	68-90	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	120-124
8631965-8	1996	Essential elements required for unsaturated fatty acid repression of OLE1 were found in the 5 and 3 region of the 111-bp sequence.	Fatty Acids, Unsaturated	32-54	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	69-73
8631965-10	1996	Two fatty acid activation genes, FAA1 and FAA4, were found to be essential for unsaturated fatty acid repression of OLE1 through the FAR sequences.	Fatty Acids, Unsaturated	79-101	long-chain fatty acid-CoA ligase FAA1	Saccharomyces cerevisiae S288C	33-37
8631965-10	1996	Two fatty acid activation genes, FAA1 and FAA4, were found to be essential for unsaturated fatty acid repression of OLE1 through the FAR sequences.	Fatty Acids, Unsaturated	79-101	long-chain fatty acid-CoA ligase FAA4	Saccharomyces cerevisiae S288C	42-46
8631965-10	1996	Two fatty acid activation genes, FAA1 and FAA4, were found to be essential for unsaturated fatty acid repression of OLE1 through the FAR sequences.	Fatty Acids, Unsaturated	79-101	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	116-120
8631965-14	1996	Unsaturated fatty acid repression of OLE1 transcription, however, is not affected by the disrupted ACBP gene.	Fatty Acids, Unsaturated	0-22	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	37-41
8631965-15	1996	These studies show that promoter elements responsible for unsaturated fatty acid-mediated transcription repression are tightly linked to OLE1 activation sequences and that OLE1 transcription levels are closely tied to acyl-CoA metabolism.	Fatty Acids, Unsaturated	58-80	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	137-141
8808111-8	1996	PLA2 induced synergistic deacylation in hypoxic tubules, suggesting that unsaturated fatty-acid accumulation might mediate its cytoprotective effect.	Fatty Acids, Unsaturated	73-95	phospholipase A2, group IB, pancreas	Mus musculus	0-4
8835400-8	1996	We conclude that increased production of GH affects both production and organ distribution of highly unsaturated fatty acids.	Fatty Acids, Unsaturated	101-124	growth hormone	Mus musculus	41-43
8631361-10	1996	The results show that the inactivation of 5-lipoxygenase in phospholipid vesicles is dependent on the structure of the unsaturated fatty acid substrate for the reaction, on the concentration of oxygen and on a turnover-independent oxidation at the active-site leading to the sequential loss of the oxygenase and pseudoperoxidase activities of the enzyme.	Fatty Acids, Unsaturated	119-141	arachidonate 5-lipoxygenase	Homo sapiens	42-56
8820108-7	1996	These results suggest that certain unsaturated fatty acids can potentiate TNF-mediated endothelial cell dysfunction and that oxidative stress may be partially responsible for these metabolic events.	Fatty Acids, Unsaturated	35-58	tumor necrosis factor	Homo sapiens	74-77
8573129-1	1996	Linoleic acid, the predominant polyunsaturated fatty acid in the diet, can be metabolized by cyclooxygenase, lipoxygenase and P450 enzymes.	Fatty Acids, Unsaturated	31-57	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	126-130
8587990-6	1996	Thus, the FAD2-2 gene-encoded omega-6 desaturase appears to be responsible for production of polyunsaturated fatty acids within membrane lipids in both vegetative tissues and developing seeds.	Fatty Acids, Unsaturated	93-120	omega-6 fatty acid desaturase	Glycine max	10-16
8856792-5	1996	We therefore examined the effects of gamma-linolenic acid and other unsaturated fatty acids on c-myc and c-fos expression by means of the polymerase chain reaction and Northern blotting.	Fatty Acids, Unsaturated	68-91	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	95-100
8856792-5	1996	We therefore examined the effects of gamma-linolenic acid and other unsaturated fatty acids on c-myc and c-fos expression by means of the polymerase chain reaction and Northern blotting.	Fatty Acids, Unsaturated	68-91	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-110
8530368-6	1995	Unsaturated fatty acids in yeast are formed by Ole1p, an oxygen-dependent delta-9 fatty acid desaturase that is an intrinsic endoplasmic reticulum membrane protein.	Fatty Acids, Unsaturated	0-23	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	47-52
8685605-1	1996	alpha-Fetoprotein (AFP), a serum alpha-globulin mainly synthesized by the fetal liver and the yolk sac, is the major carrier of polyunsaturated fatty acids during embryo-fetal development.	Fatty Acids, Unsaturated	128-155	alpha fetoprotein	Homo sapiens	0-17
8685605-1	1996	alpha-Fetoprotein (AFP), a serum alpha-globulin mainly synthesized by the fetal liver and the yolk sac, is the major carrier of polyunsaturated fatty acids during embryo-fetal development.	Fatty Acids, Unsaturated	128-155	alpha fetoprotein	Homo sapiens	19-22
8530368-10	1995	Truncation or disruption of the desaturase cytochrome b5-like domain in cells that contain the wild type diffusible b5 produced unsaturated fatty acid auxotrophy, suggesting that the cytochrome b5-like domain of Ole1p plays an essential role in the desaturase reaction.	Fatty Acids, Unsaturated	128-150	cytochrome b5 type A	Homo sapiens	43-56
8530368-10	1995	Truncation or disruption of the desaturase cytochrome b5-like domain in cells that contain the wild type diffusible b5 produced unsaturated fatty acid auxotrophy, suggesting that the cytochrome b5-like domain of Ole1p plays an essential role in the desaturase reaction.	Fatty Acids, Unsaturated	128-150	cytochrome b5 type A	Homo sapiens	183-196
8530368-10	1995	Truncation or disruption of the desaturase cytochrome b5-like domain in cells that contain the wild type diffusible b5 produced unsaturated fatty acid auxotrophy, suggesting that the cytochrome b5-like domain of Ole1p plays an essential role in the desaturase reaction.	Fatty Acids, Unsaturated	128-150	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	212-217
9072404-2	1995	The present study was performed to determine whether chronic treatments with gamma linolenic acid (n-6, GLA) or eicosapentaenoic acid (n-3, EPA) would alter serum and red blood cell (RBC) unsaturated fatty acid composition, and to determine whether these treatments would affect blood pressure (BP), serum lipid metabolism and the development of atherosclerosis in spontaneously hypertensive rats (SHR).	Fatty Acids, Unsaturated	188-210	galactosidase, alpha	Rattus norvegicus	104-107
8845162-3	1995	The enzyme phospholipase A2 cleaves membrane phospholipids causing liberation of free unsaturated fatty acids, which in turn synergistically activate protein kinase C when present with diacylglycerol and Ca.	Fatty Acids, Unsaturated	86-109	phospholipase A2 group IB	Homo sapiens	11-27
8675650-4	1995	Insulin action (high-dose clamp; MZ) correlated with composite measures of membrane unsaturation (% C20-22 polyunsaturated fatty acids [r= 0.463, P < 0.001], unsaturation index [r= -0.369, P < 0.01]), a number of individual fatty acids and with delta5 desaturase activity (r= 0.451, P < 0.001).	Fatty Acids, Unsaturated	107-134	insulin	Homo sapiens	0-7
7500172-9	1995	L-PK mRNA induction by the CP diet was significantly reduced by dietary polyunsaturated fatty acids (CPF diet), whereas the GK mRNA induction was not significantly reduced.	Fatty Acids, Unsaturated	72-99	pyruvate kinase L/R	Rattus norvegicus	0-4
8845162-6	1995	These findings suggest a model in which liberation of unsaturated fatty acids by phospholipase A2 contributes to a synergistic activation of protein kinase C, the full activation of which results in LTD induction, and the partial activation of which results in STD induction.	Fatty Acids, Unsaturated	54-77	phospholipase A2 group IB	Homo sapiens	81-97
7488547-8	1995	The findings of this study reveal that IFN-gamma might act on the enzymes controlling the labelling of the sn2 position of phospholipids (linoleic acid) but not the sn1 position (stearic acid), and this increases the polyunsaturated fatty acid content of macrophage membranes.	Fatty Acids, Unsaturated	217-243	interferon gamma	Mus musculus	39-48
7575583-0	1995	Peroxisomes contain delta 3,5,delta 2,4-dienoyl-CoA isomerase and thus possess all enzymes required for the beta-oxidation of unsaturated fatty acids by a novel reductase-dependent pathway.	Fatty Acids, Unsaturated	126-149	delta like canonical Notch ligand 3	Rattus norvegicus	20-61
7654208-6	1995	Recently we partially purified recombinant PKN from COS7 cells transfected with the cDNA construct encoding human PKN, and demonstrated that the recombinant PKN was activated by unsaturated fatty acids and limited proteolysis [Mukai, Kitagawa, Shibata et al.	Fatty Acids, Unsaturated	178-201	protein kinase N1	Homo sapiens	114-117
7654208-6	1995	Recently we partially purified recombinant PKN from COS7 cells transfected with the cDNA construct encoding human PKN, and demonstrated that the recombinant PKN was activated by unsaturated fatty acids and limited proteolysis [Mukai, Kitagawa, Shibata et al.	Fatty Acids, Unsaturated	178-201	protein kinase N1	Rattus norvegicus	43-46
7654208-6	1995	Recently we partially purified recombinant PKN from COS7 cells transfected with the cDNA construct encoding human PKN, and demonstrated that the recombinant PKN was activated by unsaturated fatty acids and limited proteolysis [Mukai, Kitagawa, Shibata et al.	Fatty Acids, Unsaturated	178-201	protein kinase N1	Homo sapiens	114-117
7547387-6	1995	These results indicate that the modulation of ICAM-1 expression does not seem to be EPA-specific, but is presumably a consequence of increased membrane fluidity due to the increased levels of unsaturated fatty acids of both the n-3 and n-6 series in the membrane.	Fatty Acids, Unsaturated	192-215	intercellular adhesion molecule 1	Homo sapiens	46-52
8546994-1	1995	Various cell stimuli occur via activation of phospholipase A2, which hydrolyses polyunsaturated fatty acids from the sn-2 position of membrane phospholipids, resulting in the formation of polyunsaturated fatty acids and lysophospholipids.	Fatty Acids, Unsaturated	80-107	phospholipase A2 group IB	Homo sapiens	45-61
8546994-1	1995	Various cell stimuli occur via activation of phospholipase A2, which hydrolyses polyunsaturated fatty acids from the sn-2 position of membrane phospholipids, resulting in the formation of polyunsaturated fatty acids and lysophospholipids.	Fatty Acids, Unsaturated	188-215	phospholipase A2 group IB	Homo sapiens	45-61
7653552-0	1995	Polyunsaturated fatty acids recruit brown adipose tissue: increased UCP content and NST capacity.	Fatty Acids, Unsaturated	0-27	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	68-71
7627706-4	1995	Analysis of mox-LDL and SIN-1-LDL showed a small increase of dienes (E234nm from 0.28 +/- 0.04 to 0.55 +/- 0.09, mean +/- SD) and thiobarbituric acid-reactive substance (from 0 to 10.6 +/- 1.5 nmol/mg, mean +/- SEM), no change in apo B electrophoretic mobility, and a minor (12% to 30%) decrease in polyunsaturated fatty acid content.	Fatty Acids, Unsaturated	299-325	monooxygenase DBH like 1	Homo sapiens	12-15
7615823-3	1995	To assess whether oxidized lipids are indeed formed by the action of 15-lipoxygenase on polyunsaturated fatty acids (PUFAs) in vivo, we have used a sensitive and specific method (chiral phase HPLC) to analyze the lipid oxidation products present in human atherosclerotic lesions.	Fatty Acids, Unsaturated	88-115	arachidonate 15-lipoxygenase	Homo sapiens	69-84
7643237-5	1995	Among fatty acids tested, all unsaturated fatty acids (oleic, linoleic and alpha-linolenic acids) were able to enhance CRBP II mRNA levels by 54-63% within 6 h, whereas a medium-chain fatty acid (caprylic acid) and a saturated fatty acid (stearic acid) elicited little effect on the CRBP II mRNA levels; palmitic acid produced only a small elevation (16%) of the CRBP II mRNA level.	Fatty Acids, Unsaturated	30-53	retinol binding protein 2	Rattus norvegicus	119-126
7643237-5	1995	Among fatty acids tested, all unsaturated fatty acids (oleic, linoleic and alpha-linolenic acids) were able to enhance CRBP II mRNA levels by 54-63% within 6 h, whereas a medium-chain fatty acid (caprylic acid) and a saturated fatty acid (stearic acid) elicited little effect on the CRBP II mRNA levels; palmitic acid produced only a small elevation (16%) of the CRBP II mRNA level.	Fatty Acids, Unsaturated	30-53	retinol binding protein 2	Rattus norvegicus	283-290
7643237-5	1995	Among fatty acids tested, all unsaturated fatty acids (oleic, linoleic and alpha-linolenic acids) were able to enhance CRBP II mRNA levels by 54-63% within 6 h, whereas a medium-chain fatty acid (caprylic acid) and a saturated fatty acid (stearic acid) elicited little effect on the CRBP II mRNA levels; palmitic acid produced only a small elevation (16%) of the CRBP II mRNA level.	Fatty Acids, Unsaturated	30-53	retinol binding protein 2	Rattus norvegicus	283-290
7475986-6	1995	Livers of TNF-alpha infused rats contained significantly less saturated and monounsaturated fatty acids and significantly more polyunsaturated fatty acids (PUFA) of the omega 3 and omega 6 series than controls.	Fatty Acids, Unsaturated	127-154	tumor necrosis factor	Rattus norvegicus	10-19
7643237-0	1995	Unsaturated fatty acids regulate gene expression of cellular retinol-binding protein, type II in rat jejunum.	Fatty Acids, Unsaturated	0-23	retinol binding protein 2	Rattus norvegicus	52-93
7615823-3	1995	To assess whether oxidized lipids are indeed formed by the action of 15-lipoxygenase on polyunsaturated fatty acids (PUFAs) in vivo, we have used a sensitive and specific method (chiral phase HPLC) to analyze the lipid oxidation products present in human atherosclerotic lesions.	Fatty Acids, Unsaturated	117-122	arachidonate 15-lipoxygenase	Homo sapiens	69-84
7890029-0	1995	Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor-1 mRNA in cultured human endothelial cells.	Fatty Acids, Unsaturated	22-45	serpin family E member 1	Homo sapiens	62-95
7579484-1	1995	Epidemiological studies suggest a causal relationship of dietary polyunsaturated fatty acids (PUFA"s) with the morbidity and mortality from breast cancer.	Fatty Acids, Unsaturated	65-92	pumilio RNA binding family member 3	Homo sapiens	94-98
7669081-0	1995	Diets enriched in unsaturated fatty acids enhance apolipoprotein A-I catabolism but do not affect either its production or hepatic mRNA abundance in cynomolgus monkeys.	Fatty Acids, Unsaturated	18-41	apolipoprotein A-I	Macaca fascicularis	50-68
7669081-3	1995	The replacement of dietary saturated fatty acids with either monounsaturated or polyunsaturated fatty acids, respectively, resulted in significant reductions of plasma total cholesterol (-17%; -30%), HDL cholesterol (-32%; -41%), and apo A-I (-37%; -44%) concentrations, while no significant differences were noted in plasma lipid or apo A-I concentrations when the MONO and POLY phases were compared.	Fatty Acids, Unsaturated	80-107	apolipoprotein A-I	Macaca fascicularis	234-241
7669081-3	1995	The replacement of dietary saturated fatty acids with either monounsaturated or polyunsaturated fatty acids, respectively, resulted in significant reductions of plasma total cholesterol (-17%; -30%), HDL cholesterol (-32%; -41%), and apo A-I (-37%; -44%) concentrations, while no significant differences were noted in plasma lipid or apo A-I concentrations when the MONO and POLY phases were compared.	Fatty Acids, Unsaturated	80-107	apolipoprotein A-I	Macaca fascicularis	334-341
7607285-5	1995	Fat of banked human milk contained 0.9% and 0.7% polyunsaturated fatty acids with 20 and 22 carbon atoms (LCP), respectively, which is comparable to that of fresh mature human milk.	Fatty Acids, Unsaturated	49-76	kelch domain containing 2	Homo sapiens	106-109
7790852-8	1995	The fourth gene encodes the rat homologue of the stearyl-CoA-desaturase 2 (SCD2) gene, which is specifically expressed in the nervous system and involved in the synthesis and regulation of long-chain unsaturated fatty acids essential for myelination.	Fatty Acids, Unsaturated	200-223	stearoyl-Coenzyme A desaturase 2	Rattus norvegicus	49-73
7790852-8	1995	The fourth gene encodes the rat homologue of the stearyl-CoA-desaturase 2 (SCD2) gene, which is specifically expressed in the nervous system and involved in the synthesis and regulation of long-chain unsaturated fatty acids essential for myelination.	Fatty Acids, Unsaturated	200-223	stearoyl-Coenzyme A desaturase 2	Rattus norvegicus	75-79
7790873-4	1995	The relative amount of polyunsaturated fatty acids (as determined with soybean lipoxygenase) was increased in whole brains and crude synaptosomal membranes of the type II diabetic mice.	Fatty Acids, Unsaturated	23-50	linoleate 9S-lipoxygenase-4	Glycine max	79-91
8521454-13	1995	Consistent with this finding, we found that a large number of unsaturated fatty acids could reproduce the effect of arachidonate on [Ca2+]i and beta-glucuronidase release.	Fatty Acids, Unsaturated	62-85	glucuronidase beta	Homo sapiens	144-162
7890029-1	1995	To determine whether unsaturated fatty acids induce changes in the mRNA level of plasminogen activator inhibitor type-1 (PAI-1), Northern analyses were performed on human umbilical vein endothelial cells (HUVEC) and vascular smooth muscle cells that were treated with two common fatty acids.	Fatty Acids, Unsaturated	21-44	serpin family E member 1	Homo sapiens	81-119
7890029-1	1995	To determine whether unsaturated fatty acids induce changes in the mRNA level of plasminogen activator inhibitor type-1 (PAI-1), Northern analyses were performed on human umbilical vein endothelial cells (HUVEC) and vascular smooth muscle cells that were treated with two common fatty acids.	Fatty Acids, Unsaturated	21-44	serpin family E member 1	Homo sapiens	121-126
7890029-4	1995	Our results indicate that unsaturated fatty acids selectively increase PAI-1 mRNA levels in endothelial cells, the primary source of circulating PAI-1 in vivo.	Fatty Acids, Unsaturated	26-49	serpin family E member 1	Homo sapiens	71-76
7890029-4	1995	Our results indicate that unsaturated fatty acids selectively increase PAI-1 mRNA levels in endothelial cells, the primary source of circulating PAI-1 in vivo.	Fatty Acids, Unsaturated	26-49	serpin family E member 1	Homo sapiens	145-150
7784451-1	1995	Polyunsaturated fatty acids enhance the proliferation of mouse mammary epithelial cells stimulated by epidermal growth factor (EGF) by modulating the post-receptor signaling pathways.	Fatty Acids, Unsaturated	0-27	epidermal growth factor	Mus musculus	102-125
31121672-2	1995	Milk from cows fed the experimental diets contained higher levels of both long chain (C18-C18:2) and unsaturated fatty acids than the milk from cows fed the Control diet.	Fatty Acids, Unsaturated	101-124	Weaning weight-maternal milk	Bos taurus	0-4
7596352-0	1995	Influence of unsaturated fatty acids on the production of tumour necrosis factor and interleukin-6 by rat peritoneal macrophages.	Fatty Acids, Unsaturated	13-36	tumor necrosis factor	Rattus norvegicus	58-80
7596352-0	1995	Influence of unsaturated fatty acids on the production of tumour necrosis factor and interleukin-6 by rat peritoneal macrophages.	Fatty Acids, Unsaturated	13-36	interleukin 6	Rattus norvegicus	85-98
7596352-1	1995	The effect of individual unsaturated fatty acids on the release of tumour necrosis factor (TNF) and interleukin 6 (IL6) was investigated in thioglycollate-induced rat peritoneal macrophages.	Fatty Acids, Unsaturated	25-48	tumor necrosis factor	Rattus norvegicus	67-89
7596352-1	1995	The effect of individual unsaturated fatty acids on the release of tumour necrosis factor (TNF) and interleukin 6 (IL6) was investigated in thioglycollate-induced rat peritoneal macrophages.	Fatty Acids, Unsaturated	25-48	tumor necrosis factor	Rattus norvegicus	91-94
7596352-1	1995	The effect of individual unsaturated fatty acids on the release of tumour necrosis factor (TNF) and interleukin 6 (IL6) was investigated in thioglycollate-induced rat peritoneal macrophages.	Fatty Acids, Unsaturated	25-48	interleukin 6	Rattus norvegicus	100-113
7596352-1	1995	The effect of individual unsaturated fatty acids on the release of tumour necrosis factor (TNF) and interleukin 6 (IL6) was investigated in thioglycollate-induced rat peritoneal macrophages.	Fatty Acids, Unsaturated	25-48	interleukin 6	Rattus norvegicus	115-118
7596352-13	1995	These results show for the first time that unsaturated fatty acids have an effect on macrophage PLA2 activity and that PGE2 may be a potent modulator of IL6 production.	Fatty Acids, Unsaturated	43-66	phospholipase A2 group IB	Rattus norvegicus	96-100
7769968-1	1995	Soybean lipoxygenase (LOX; EC 1.12.11.12) catalyzes the oxygenation of polyunsaturated fatty acids, acylglycerols and phosphoglycerols, producing a regio- and enantiospecific hydroperoxide product.	Fatty Acids, Unsaturated	71-98	linoleate 9S-lipoxygenase-4	Glycine max	8-20
7769968-1	1995	Soybean lipoxygenase (LOX; EC 1.12.11.12) catalyzes the oxygenation of polyunsaturated fatty acids, acylglycerols and phosphoglycerols, producing a regio- and enantiospecific hydroperoxide product.	Fatty Acids, Unsaturated	71-98	linoleate 9S-lipoxygenase-4	Glycine max	22-25
7784451-1	1995	Polyunsaturated fatty acids enhance the proliferation of mouse mammary epithelial cells stimulated by epidermal growth factor (EGF) by modulating the post-receptor signaling pathways.	Fatty Acids, Unsaturated	0-27	epidermal growth factor	Mus musculus	127-130
7837930-8	1995	Decreased PPAR gene expression in ethanol-fed rats might result from a decrease in the content of polyunsaturated fatty acid in the liver.	Fatty Acids, Unsaturated	98-124	peroxisome proliferator activated receptor alpha	Rattus norvegicus	10-14
7772064-9	1995	Also, lower HDL phospholipid and PUFA content may explain a different apo A-I conformation in patients with myocardial infarction.	Fatty Acids, Unsaturated	33-37	apolipoprotein A1	Homo sapiens	70-75
7480063-1	1995	The stearoyl-CoA desaturase gene family encodes stearoyl-CoA desaturase, the key enzyme involved in the biosynthesis of unsaturated fatty acids, as well as in the regulation of this process.	Fatty Acids, Unsaturated	120-143	stearoyl-CoA desaturase	Homo sapiens	4-27
18475612-6	1995	It is concluded that IFN-gamma, IL-4 and IL-10 may differentially regulate macrophage activation via effects on the metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	130-157	interferon gamma	Mus musculus	21-30
18475612-6	1995	It is concluded that IFN-gamma, IL-4 and IL-10 may differentially regulate macrophage activation via effects on the metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	130-157	interleukin 4	Mus musculus	32-36
18475612-6	1995	It is concluded that IFN-gamma, IL-4 and IL-10 may differentially regulate macrophage activation via effects on the metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	130-157	interleukin 10	Mus musculus	41-46
8789319-4	1995	Furthermore, marine fish oil (FO) rich in n-3 polyunsaturated fatty acids (PUFA), added to the basal diet (30 wt % of n-3 PUFA) reduced the GLUT4 protein levels (B: 100 +/- 3 vs B+FO: 42 +/- 4%, p < 0.005) in control rats to values similar to those found in HTG rats (B: 46 +/- 4%).	Fatty Acids, Unsaturated	75-79	solute carrier family 2 member 4	Rattus norvegicus	140-145
7480063-1	1995	The stearoyl-CoA desaturase gene family encodes stearoyl-CoA desaturase, the key enzyme involved in the biosynthesis of unsaturated fatty acids, as well as in the regulation of this process.	Fatty Acids, Unsaturated	120-143	stearoyl-CoA desaturase	Homo sapiens	48-71
8001151-2	1994	Transcriptional activation by PPAR gamma 2 is potentiated by a variety of lipids and lipid-like compounds, including naturally occurring polyunsaturated fatty acids.	Fatty Acids, Unsaturated	137-164	peroxisome proliferator activated receptor alpha	Homo sapiens	30-34
7735895-9	1994	Substances as fibrates, retinoic acid, polyunsaturated fatty acids activate specific types of receptors-PPAR (peroxisome proliferators activated receptors) belonging to the superfamily of receptors activated by steroid hormones, thyroid hormones, and D-vitamins.	Fatty Acids, Unsaturated	39-66	peroxisome proliferator activated receptor alpha	Homo sapiens	104-108
7712594-5	1994	The implication is that during tumor promotion of liver carcinogenesis, these genotoxic and nongenotoxic carcinogens modify the normal process by which L-FABP, functioning as a specific receptor of unsaturated fatty acids or their metabolites, promotes the multiplication of hepatocytes.	Fatty Acids, Unsaturated	198-221	fatty acid binding protein 1	Rattus norvegicus	152-158
7833834-2	1994	and based on swelling, polyunsaturated fatty acids release and calcium influx, induced the activation of SDH (succinate dehydrogenase; EC 1.3.9.9.)	Fatty Acids, Unsaturated	23-50	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	105-108
7945381-0	1994	Activation of PKN, a novel 120-kDa protein kinase with leucine zipper-like sequences, by unsaturated fatty acids and by limited proteolysis.	Fatty Acids, Unsaturated	89-112	protein kinase N1	Homo sapiens	14-17
7945381-2	1994	Using serine containing synthetic peptides based on PKC pseudosubstrate sites as the phosphate acceptors, kinase activities estimated from partially purified PKN were not stimulated by Ca2+/phosphatidylserine/diolein but were activated several-fold to several tens-fold by 40 microM unsaturated fatty acids, such as arachidonic acid, linoleic acid, and oleic acid.	Fatty Acids, Unsaturated	283-306	protein kinase N1	Homo sapiens	158-161
7945381-3	1994	Autophosphorylation of the immunoprecipitates using anti-PKN antiserum was also stimulated by various unsaturated fatty acids.	Fatty Acids, Unsaturated	102-125	protein kinase N1	Homo sapiens	57-60
7833834-2	1994	and based on swelling, polyunsaturated fatty acids release and calcium influx, induced the activation of SDH (succinate dehydrogenase; EC 1.3.9.9.)	Fatty Acids, Unsaturated	23-50	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	110-133
7838147-0	1994	Dietary polyunsaturated fatty acids interfere with the insulin/glucose activation of L-type pyruvate kinase gene transcription.	Fatty Acids, Unsaturated	8-35	pyruvate kinase L/R	Rattus norvegicus	85-107
7999637-1	1994	We have previously shown that interferon-gamma (IFN-gamma) increases the polyunsaturated fatty acid content of membrane phospholipids in cells that were sensitive to endotoxin.	Fatty Acids, Unsaturated	73-99	interferon gamma	Mus musculus	30-46
7999637-1	1994	We have previously shown that interferon-gamma (IFN-gamma) increases the polyunsaturated fatty acid content of membrane phospholipids in cells that were sensitive to endotoxin.	Fatty Acids, Unsaturated	73-99	interferon gamma	Mus musculus	48-57
7829074-1	1994	A key enzyme in the mitochondrial beta-oxidation of unsaturated fatty acids is the 3,2-trans-enoyl-CoA isomerase (DCI; EC 5.3.3.8).	Fatty Acids, Unsaturated	52-75	enoyl-CoA delta isomerase 1	Homo sapiens	114-117
8068722-7	1994	L-FABP showed a preference for the binding of long-chain saturated and unsaturated fatty acids up to C24:1, whereas the M-FABP has a preference for unsaturated fatty acids, especially those with 18 C atoms.	Fatty Acids, Unsaturated	71-94	fatty acid binding protein 1	Homo sapiens	0-6
8053897-4	1994	In agreement with the mixed-vesicle models, AA was the major unsaturated fatty acid hydrolysed from membranes by the 110 kDa PLA2, suggesting that this PLA2 is selective in releasing AA from natural membranes.	Fatty Acids, Unsaturated	61-83	phospholipase A2 group IB	Homo sapiens	125-129
8053894-0	1994	Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin.	Fatty Acids, Unsaturated	109-132	coagulation factor II, thrombin	Homo sapiens	15-23
8059770-6	1994	In addition, insulin levels were inversely associated with the intake of dietary fiber and polyunsaturated fatty acids, which could not be accounted for by variables such as energy intake, body mass index, physical activity, prescribed diets, or the presence of coronary heart disease.	Fatty Acids, Unsaturated	91-118	insulin	Homo sapiens	13-20
8053894-0	1994	Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin.	Fatty Acids, Unsaturated	109-132	thrombomodulin	Homo sapiens	24-38
8053897-4	1994	In agreement with the mixed-vesicle models, AA was the major unsaturated fatty acid hydrolysed from membranes by the 110 kDa PLA2, suggesting that this PLA2 is selective in releasing AA from natural membranes.	Fatty Acids, Unsaturated	61-83	phospholipase A2 group IB	Homo sapiens	152-156
8053894-0	1994	Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin.	Fatty Acids, Unsaturated	109-132	thrombomodulin	Homo sapiens	227-241
8053897-5	1994	By contrast, Type I and Type II PLA2s were less selective in releasing AA from phospholipids and released a variety of unsaturated fatty acids at molar ratios that were proportional to the ratios of these fatty acids in U937 microsomal membranes.	Fatty Acids, Unsaturated	119-142	phospholipase A2 group IIA	Homo sapiens	32-37
8053897-10	1994	Taken together, these data indicate that the 110 kDa PLA2 selectively releases AA from U937 membranes, whereas Type I and Type II PLA2 release a variety of unsaturated fatty acids.	Fatty Acids, Unsaturated	156-179	phospholipase A2 group IB	Homo sapiens	130-134
7800118-3	1994	Two of these clones were characterized further and one clone, pC26.H2, was found to be closely related to mouse stearoyl-CoA desaturase 2 (SCD2), which catalyzes the synthesis of unsaturated fatty acid.	Fatty Acids, Unsaturated	179-201	stearoyl-Coenzyme A desaturase 2	Mus musculus	112-137
7800118-3	1994	Two of these clones were characterized further and one clone, pC26.H2, was found to be closely related to mouse stearoyl-CoA desaturase 2 (SCD2), which catalyzes the synthesis of unsaturated fatty acid.	Fatty Acids, Unsaturated	179-201	stearoyl-Coenzyme A desaturase 2	Mus musculus	139-143
8053940-0	1994	Polyunsaturated fatty acids reduce pyrogen-induced tissue factor expression in human monocytes.	Fatty Acids, Unsaturated	0-27	coagulation factor III, tissue factor	Homo sapiens	51-64
8053940-3	1994	Other polyunsaturated fatty acids such as linoleic or linolenic acid also reduced tissue factor expression whereas palmitic acid was ineffective.	Fatty Acids, Unsaturated	6-33	coagulation factor III, tissue factor	Homo sapiens	82-95
8053940-5	1994	These data therefore suggest that the well-recognized antithrombotic and antiatherogenic effect of polyunsaturated fatty acids may in part be mediated through an inhibition of tissue factor expression in monocyte/macrophages.	Fatty Acids, Unsaturated	99-126	coagulation factor III, tissue factor	Homo sapiens	176-189
8011678-1	1994	The simultaneous incorporation of a saturated fatty acid in the sn-1 position and an unsaturated fatty acid in the sn-2 position in phosphatidylcholine (PC) and ethanolamine (PE) was studied in isolated liver cells.	Fatty Acids, Unsaturated	85-107	solute carrier family 38 member 5	Homo sapiens	115-119
7920739-2	1994	Transgenic mice expressing the ovine metallothionein 1a-ovine growth hormone (oMt1a-oGH) fusion gene exhibited significantly elevated levels of a number of long chain polyunsaturated fatty acids in serum, including arachidonic acid.	Fatty Acids, Unsaturated	167-194	growth hormone	Mus musculus	62-76
7920739-2	1994	Transgenic mice expressing the ovine metallothionein 1a-ovine growth hormone (oMt1a-oGH) fusion gene exhibited significantly elevated levels of a number of long chain polyunsaturated fatty acids in serum, including arachidonic acid.	Fatty Acids, Unsaturated	167-194	glycoprotein hormone beta 5	Mus musculus	84-87
7920739-5	1994	As rare intermediate long chain polyunsaturated fatty acids such as eicosatrienoic acid (20:3n-9) were also significantly elevated, we conclude that these observations reflect increased activity of the delta-5 and delta-6 desaturase enzymes.	Fatty Acids, Unsaturated	32-59	fatty acid desaturase 2	Mus musculus	202-232
8068238-0	1994	[Selective incorporation of polyunsaturated fatty acids of the n-6 and n-3 class into phospholipid molecular species by cultured monocytes (THP-1)].	Fatty Acids, Unsaturated	28-55	GLI family zinc finger 2	Homo sapiens	140-145
8192673-11	1994	The results suggest that dietary omega-3 and polyunsaturated fatty acids increase insulin binding to sarcolemma by changing the fatty acyl composition of phospholipid surrounding the insulin receptor, and this might be the mechanism by which dietary fatty acids modify insulin action.	Fatty Acids, Unsaturated	45-72	insulin receptor	Rattus norvegicus	183-199
7980870-5	1994	Like bovine serum albumin (BSA), gizzard myoglobin has the highest affinity for unsaturated fatty acids and a lower affinity for saturated fatty acids or dyes.	Fatty Acids, Unsaturated	80-103	myoglobin	Gallus gallus	41-50
8200132-10	1994	Though constituting only 3% of dietary fatty acids, 5,11,14-ETA was the most abundant long chain polyunsaturated fatty acid in the serum phospholipids, suggesting that it very successfully competed with 20:4 as a constituent of membrane lipids.	Fatty Acids, Unsaturated	97-123	endothelin receptor type A	Mus musculus	60-63
8189063-4	1994	Mast cells incubated with groups I or II PLA2 selectively release polyunsaturated fatty acids, such as AA, into supernatant fluids.	Fatty Acids, Unsaturated	66-93	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	41-45
8069236-3	1994	Cytochrome P 450 level was decreased by n-3 PUFA (Polyunsaturated fatty acid) deficiency.	Fatty Acids, Unsaturated	50-76	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
24203271-2	1994	As PUFA inhibit testicular steroidogenesis in the rat through activation of protein kinase C (PKC), the present studies were undertaken to characterize the properties of PKC in the goldfish testis and to test the effects of selected PUFA on PKC activity.	Fatty Acids, Unsaturated	3-7	protein kinase C, gamma	Rattus norvegicus	76-92
24203271-2	1994	As PUFA inhibit testicular steroidogenesis in the rat through activation of protein kinase C (PKC), the present studies were undertaken to characterize the properties of PKC in the goldfish testis and to test the effects of selected PUFA on PKC activity.	Fatty Acids, Unsaturated	3-7	protein kinase C, gamma	Rattus norvegicus	94-97
8205390-1	1994	The cytochrome P-450-dependent monooxygenase in musk shrew (suncus; Suncus murinus) liver microsomes metabolized unsaturated fatty acids (oleic, linoleic, alpha-linolenic and arachidonic acids) to a variety of oxygenated products.	Fatty Acids, Unsaturated	113-136	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	4-20
8022751-0	1994	Regulation of polyunsaturated fatty acid-stimulated insulin release by GIP in isolated perifused islets.	Fatty Acids, Unsaturated	14-40	insulin	Homo sapiens	52-59
8022751-0	1994	Regulation of polyunsaturated fatty acid-stimulated insulin release by GIP in isolated perifused islets.	Fatty Acids, Unsaturated	14-40	gastric inhibitory polypeptide	Homo sapiens	71-74
8022751-2	1994	In the present study we examined, through the use of isolated perifused murine islets, the effect of GIP on insulin secretion that was stimulated by polyunsaturated fatty acids (PUFA) in the presence of low or high glucose concentrations.	Fatty Acids, Unsaturated	149-176	gastric inhibitory polypeptide	Mus musculus	101-104
8022751-2	1994	In the present study we examined, through the use of isolated perifused murine islets, the effect of GIP on insulin secretion that was stimulated by polyunsaturated fatty acids (PUFA) in the presence of low or high glucose concentrations.	Fatty Acids, Unsaturated	149-176	insulin	Homo sapiens	108-115
7910016-0	1994	Transcriptional control of the stearoyl-CoA desaturase-1 gene by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	65-92	stearoyl-Coenzyme A desaturase 1	Mus musculus	31-56
7910016-5	1994	The reduction of hepatic SCD1 mRNA appears to be primarily due to inhibition of SCD1 gene transcription since polyunsaturated fatty acids caused a decrease in run-on transcription of the gene comparable to the decrease in message level.	Fatty Acids, Unsaturated	110-137	stearoyl-Coenzyme A desaturase 1	Mus musculus	25-29
7910016-6	1994	Consistent with the effects observed in vivo, unsaturated fatty acids suppressed the expression of SCD1 mRNA by rat hepatocytes cultured in serum-free medium.	Fatty Acids, Unsaturated	46-69	stearoyl-CoA desaturase	Rattus norvegicus	99-103
7910016-8	1994	Thus, the SCD1 gene, like the fatty acid synthase and S14 genes, undergoes coordinate transcriptional down-regulation in response to unsaturated fatty acids.	Fatty Acids, Unsaturated	133-156	stearoyl-Coenzyme A desaturase 1	Mus musculus	10-14
7910016-8	1994	Thus, the SCD1 gene, like the fatty acid synthase and S14 genes, undergoes coordinate transcriptional down-regulation in response to unsaturated fatty acids.	Fatty Acids, Unsaturated	133-156	thyroid hormone responsive	Mus musculus	54-57
7931720-0	1994	Insulin response to glucose-6-phosphate dehydrogenase activity is elevated in rats fed diets low in polyunsaturated fatty acids.	Fatty Acids, Unsaturated	100-127	glucose-6-phosphate dehydrogenase	Rattus norvegicus	20-53
7931720-6	1994	These findings indicate that augment in insulin dose-response to G6PD and elevation of its activity shown in rats fed diets low in polyunsaturated fatty acid are associated with lowering the PUFA/SFA ratio in plasma membrane phospholipid.	Fatty Acids, Unsaturated	131-157	glucose-6-phosphate dehydrogenase	Rattus norvegicus	65-69
8125741-8	1994	Species containing polyunsaturated fatty acids in both the sn-1 and sn-2 positions (dipolyenes) were present only in the diacyl subclass and comprised 16% of the total species.	Fatty Acids, Unsaturated	19-46	solute carrier family 38 member 3	Homo sapiens	59-63
8057221-5	1994	The proportions of the major long-chain polyunsaturated fatty acids (LCP), 20:3n-6, 20:4n-6, 22:5n-3 and 22:6n-3, were highest at 1 week and decreased thereafter in both types of milk.	Fatty Acids, Unsaturated	40-67	kelch domain containing 2	Homo sapiens	69-72
8125741-8	1994	Species containing polyunsaturated fatty acids in both the sn-1 and sn-2 positions (dipolyenes) were present only in the diacyl subclass and comprised 16% of the total species.	Fatty Acids, Unsaturated	19-46	solute carrier family 38 member 5	Homo sapiens	68-72
8127910-0	1994	External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	79-106	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	69-74
8016203-1	1994	The rate constants for the reactive (kR) and unreactive (kQ) interaction of singlet molecular oxygen with three esters of polyunsaturated fatty acids (PUFA: cis-methyl oleate, MO; cis-methyl linoleate, MLA and cis-ethyl linolenate, ELN) are determined.	Fatty Acids, Unsaturated	122-149	pumilio RNA binding family member 3	Homo sapiens	151-155
8127910-4	1994	Inhibition of Kv1.5 channel activity by polyunsaturated fatty acids (acceleration of the apparent inactivation and decrease of the peak current) is similar to that produced by the class III antiarrhythmic tedisamil.	Fatty Acids, Unsaturated	40-67	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	14-19
8110809-3	1994	Evidence is presented that soybean lipoxygenase-2, at variance with the type-1 enzyme, oxygenates the esterified unsaturated fatty acid moieties in biomembranes, whereas membrane-embedded free unsaturated fatty acid moieties were not a suitable substrate for either isoenzyme.	Fatty Acids, Unsaturated	113-135	seed linoleate 9S-lipoxygenase-2	Glycine max	35-49
7508265-2	1994	Previous work in our laboratory has provided experimental support for the suggestion that the entry of unsaturated fatty acids into growing, normal and neoplastic cells may be regulated by AFP.	Fatty Acids, Unsaturated	103-126	alpha fetoprotein	Homo sapiens	189-192
8302856-6	1994	The convergence of the two types of genotoxic carcinogens with the two classes of PP nongenotoxic carcinogens, and also with unsaturated fatty acids, at L-FABP actions in inducing mitogenesis allows the following hypothesis.	Fatty Acids, Unsaturated	125-148	fatty acid binding protein 1	Rattus norvegicus	153-159
8206642-3	1994	The PLA2"s are a group of enzymes that release unsaturated fatty acids from the sn2-position of membrane phospholipids.	Fatty Acids, Unsaturated	47-70	phospholipase A2 group IB	Homo sapiens	4-8
8302856-7	1994	During tumor promotion of carcinogenesis in vivo, these groups of genotoxic and nongenotoxic carcinogens act on the normal process by which L-FABP, functioning as a specific receptor of unsaturated fatty acids or their metabolites, promotes hepatocyte proliferation.	Fatty Acids, Unsaturated	186-209	fatty acid binding protein 1	Rattus norvegicus	140-146
8300563-5	1994	The purification of delta 3,5, delta 2,4-dienoyl-CoA isomerase completes the characterization of the enzymes functioning in the NADPH-dependent pathway for the beta-oxidation of unsaturated fatty acids with double bonds extending from odd-numbered carbon atoms.	Fatty Acids, Unsaturated	178-201	delta like canonical Notch ligand 3	Rattus norvegicus	20-62
7946534-3	1994	By inhibiting fatty acid biosynthesis, dietary PUFAs reduce the availability of substrate for delta 9 desaturase (7, 22, 34, 36) and in turn reduce the availability of (n-9) fatty acids for incorporation into plasma membranes.	Fatty Acids, Unsaturated	47-52	fatty acid desaturase 3	Homo sapiens	94-112
7905448-6	1994	The decrease in the dietary supply of fat after weaning to a high-carbohydrate diet could also potentiate the accumulation of FAS and ACC mRNA in liver because long-chain poly-unsaturated fatty acids are potent inhibitors of the expression of the genes encoding liver lipogenic enzymes.	Fatty Acids, Unsaturated	171-199	fatty acid synthase	Rattus norvegicus	126-129
7905448-7	1994	A direct effect of fatty acids on a cis-acting element of the lipogenic enzyme genes could be involved, as the regulatory region of FAS gene contains a polyunsaturated fatty acid response element that shares some similarity with the peroxisome proliferator-activated receptor recently described.	Fatty Acids, Unsaturated	152-178	fatty acid synthase	Rattus norvegicus	132-135
8151138-1	1993	Interferon-gamma (IFN-gamma) specifically induced the uptake of the unsaturated fatty acid [14C]linoleic acid into membrane phospholipids of the murine macrophage-like P388D cell lineage, but did not alter the incorporation of the saturated fatty acid [14C]stearic acid.	Fatty Acids, Unsaturated	68-90	interferon gamma	Mus musculus	0-16
8022846-0	1994	Oxygenation of polyunsaturated fatty acids by cytochrome P450 monooxygenases.	Fatty Acids, Unsaturated	15-42	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	57-61
8022846-1	1994	Polyunsaturated fatty acids can be oxygenated by P450 in different ways--by epoxidation, by hydroxylation of the omega-side chain, by allylic and bis-allylic hydroxylation and by hydroxylation with double bond migration.	Fatty Acids, Unsaturated	0-27	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	49-53
8151138-1	1993	Interferon-gamma (IFN-gamma) specifically induced the uptake of the unsaturated fatty acid [14C]linoleic acid into membrane phospholipids of the murine macrophage-like P388D cell lineage, but did not alter the incorporation of the saturated fatty acid [14C]stearic acid.	Fatty Acids, Unsaturated	68-90	interferon gamma	Mus musculus	18-27
8290478-0	1993	Chemical and alpha-chymotrypsin-mediated proteolytic degradation of insulin in bile salt-unsaturated fatty acid mixed micellar systems.	Fatty Acids, Unsaturated	89-111	insulin	Homo sapiens	68-75
8123200-2	1993	By varying the dietary fatty acid composition we showed that the pathology was worsened by increasing linoleic acid or polyunsaturated fatty acids (PUFAs) in the diet where cytochrome P4502E1 (CYP2E1) was increased posttranslationally by high BAL.	Fatty Acids, Unsaturated	119-146	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	173-191
8123200-2	1993	By varying the dietary fatty acid composition we showed that the pathology was worsened by increasing linoleic acid or polyunsaturated fatty acids (PUFAs) in the diet where cytochrome P4502E1 (CYP2E1) was increased posttranslationally by high BAL.	Fatty Acids, Unsaturated	119-146	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	193-199
8123200-2	1993	By varying the dietary fatty acid composition we showed that the pathology was worsened by increasing linoleic acid or polyunsaturated fatty acids (PUFAs) in the diet where cytochrome P4502E1 (CYP2E1) was increased posttranslationally by high BAL.	Fatty Acids, Unsaturated	148-153	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	173-191
8123200-2	1993	By varying the dietary fatty acid composition we showed that the pathology was worsened by increasing linoleic acid or polyunsaturated fatty acids (PUFAs) in the diet where cytochrome P4502E1 (CYP2E1) was increased posttranslationally by high BAL.	Fatty Acids, Unsaturated	148-153	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	193-199
8263597-5	1993	Metabolic experiments suggested that the significantly reduced concentrations of apolipoprotein B observed during the monounsaturated and polyunsaturated fatty acid phases relative to the saturated fatty acid phase could not be entirely explained by changes in LDL apolipoprotein B clearance but rather were likely due to decreased LDL apolipoprotein B production rates.	Fatty Acids, Unsaturated	138-164	apolipoprotein B-100	Macaca fascicularis	81-97
8263597-6	1993	However, enhanced LDL apolipoprotein B catabolism accounted for the even greater reductions in VLDL + LDL cholesterol and apolipoprotein B concentrations observed during the polyunsaturated fatty acid phase vs. the monounsaturated fatty acid phase.	Fatty Acids, Unsaturated	174-200	apolipoprotein B-100	Macaca fascicularis	22-38
8263597-6	1993	However, enhanced LDL apolipoprotein B catabolism accounted for the even greater reductions in VLDL + LDL cholesterol and apolipoprotein B concentrations observed during the polyunsaturated fatty acid phase vs. the monounsaturated fatty acid phase.	Fatty Acids, Unsaturated	174-200	apolipoprotein B-100	Macaca fascicularis	122-138
8263597-7	1993	Our data suggest that monounsaturated and polyunsaturated fatty acids lower apolipoprotein B concentrations by distinct mechanisms, with polyunsaturated fatty acids affecting LDL apolipoprotein B catabolism as well as production.	Fatty Acids, Unsaturated	42-69	apolipoprotein B-100	Macaca fascicularis	76-92
8218304-7	1993	ATPase activation was dependent on phospholipid fatty acyl chain composition: ATPase activity increased with increasing PS acyl chain length, and the optimal fatty acid composition was one saturated and one unsaturated fatty acid.	Fatty Acids, Unsaturated	207-229	dynein axonemal heavy chain 8	Homo sapiens	0-6
8218304-7	1993	ATPase activation was dependent on phospholipid fatty acyl chain composition: ATPase activity increased with increasing PS acyl chain length, and the optimal fatty acid composition was one saturated and one unsaturated fatty acid.	Fatty Acids, Unsaturated	207-229	dynein axonemal heavy chain 8	Homo sapiens	78-84
7692957-10	1993	These findings indicated a colocalization of epitopes derived from lipid peroxidation of polyunsaturated fatty acids and epitopes specific for apoB and apo(a) during atherogenesis in humans.	Fatty Acids, Unsaturated	89-116	apolipoprotein B	Homo sapiens	143-147
8290478-4	1993	In this study, the effect of bile salt-unsaturated fatty acid mixed micelles on alpha-chymotryptic degradation of insulin was further characterized.	Fatty Acids, Unsaturated	39-61	insulin	Homo sapiens	114-121
8237254-2	1993	The present study was undertaken to localize the site of interaction of polyunsaturated fatty acids on the receptor by comparing the differential effects of docosahexaenoic acid (a 22-carbon polyunsaturated fatty acid of the series n-3) on antagonist (RU486) and agonist binding, by covalent cross-linking of the hsp 90 and other proteins to the receptor to attempt to mask the site of interaction, by limited trypsinization to cleave the site and by using antibodies against specific epitopes to prevent fatty acid access by steric hindrance.	Fatty Acids, Unsaturated	72-99	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	313-319
8218206-1	1993	During beta-oxidation of unsaturated fatty acids, mitochondrial 3,2-trans-enoyl-CoA isomerase (mECI) converts 3-cis- or 3-trans-enoyl-CoA intermediates into their 2-trans isomers.	Fatty Acids, Unsaturated	25-48	enoyl-Coenzyme A delta isomerase 1	Mus musculus	95-99
8224148-8	1993	Knowledge of the gene organization and availability of genomic clones for mouse mECI will facilitate the study of unsaturated fatty acid metabolism in normal and pathological states.	Fatty Acids, Unsaturated	114-136	enoyl-Coenzyme A delta isomerase 1	Mus musculus	80-84
8237254-2	1993	The present study was undertaken to localize the site of interaction of polyunsaturated fatty acids on the receptor by comparing the differential effects of docosahexaenoic acid (a 22-carbon polyunsaturated fatty acid of the series n-3) on antagonist (RU486) and agonist binding, by covalent cross-linking of the hsp 90 and other proteins to the receptor to attempt to mask the site of interaction, by limited trypsinization to cleave the site and by using antibodies against specific epitopes to prevent fatty acid access by steric hindrance.	Fatty Acids, Unsaturated	72-98	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	313-319
24248580-1	1993	Several unsaturated aldehydes are produced from polyunsaturated fatty acids via the lipoxygenase pathway when soybean (Glycine max) plants are wounded mechanically or by pathogens.	Fatty Acids, Unsaturated	48-75	linoleate 9S-lipoxygenase-4	Glycine max	84-96
8408240-3	1993	The present study demonstrates the abilities of L-FABP to promote DNA synthesis and cell growth, preserve cell morphology, extend survival, and act cooperatively with unsaturated fatty acids in the transfected hepatoma cells in the absence of serum.	Fatty Acids, Unsaturated	167-190	fatty acid binding protein 1	Rattus norvegicus	48-54
8343495-7	1993	Dietary intake of n-3 polyunsaturated fatty acids (PUFAs) showed negative associations with fibrinogen, factor VIII, and vWF (blacks and whites) and a positive association with protein C (whites only).	Fatty Acids, Unsaturated	51-56	von Willebrand factor	Homo sapiens	121-124
8394629-9	1993	Animal-derived fat intake displayed an inverse association both with the P:S ratio and the C18 polyunsaturated fatty acid content of adipose tissue, lending internal validity to the dietary data.	Fatty Acids, Unsaturated	95-121	Bardet-Biedl syndrome 9	Homo sapiens	91-94
8378318-0	1993	Polyunsaturated fatty acids inhibit S14 gene transcription in rat liver and cultured hepatocytes.	Fatty Acids, Unsaturated	0-27	thyroid hormone responsive	Rattus norvegicus	36-39
8212085-0	1993	Unsaturated fatty acid modulation of glucocorticoid receptor binding in L2 cells.	Fatty Acids, Unsaturated	0-22	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	37-60
8251064-2	1993	In the case of bovine beta-lactoglobulin, the apparent binding constants for most of the saturated and unsaturated fatty acids were in the range of 10(-7) M at neutral pH.	Fatty Acids, Unsaturated	103-126	beta-lactoglobulin	Bos taurus	22-40
8212085-7	1993	This suggests that unsaturated fatty acids modulate L2 cell glucocorticoid receptor by binding to sites different from the glucocorticoid binding sites in the receptor.	Fatty Acids, Unsaturated	19-42	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	60-83
8427602-5	1993	These results indicate that unsaturated fatty acids induce alterations in rABP steroid-binding properties that could modulate the endocrine function of rABP.	Fatty Acids, Unsaturated	28-51	sex hormone binding globulin	Rattus norvegicus	74-78
8489126-2	1993	There appear to be only a few saturated fatty acids and an even lesser number of unsaturated fatty acids that significantly interact with cholesterol in the liver cell to alter hepatic LDL receptor activity.	Fatty Acids, Unsaturated	81-104	low density lipoprotein receptor	Homo sapiens	185-197
8395252-9	1993	At present it is not known if the phospholipase A2 that accumulates free polyunsaturated fatty acids is the same as the one that gives rise to PAF.	Fatty Acids, Unsaturated	73-100	phospholipase A2 group IB	Rattus norvegicus	34-50
8382052-7	1993	Substitution of an unsaturated fatty acid in the sn-2 position of distearin also dramatically increased the CDP-choline Km value as well as the Vmax.	Fatty Acids, Unsaturated	19-41	cut-like homeobox 1	Mus musculus	108-111
8232253-1	1993	The presence of fatty acid-binding protein (FABP) in the embryonic chick retina may be linked to the demand for polyunsaturated fatty acids in this developing neural tissue.	Fatty Acids, Unsaturated	112-139	fatty acid binding protein 1	Gallus gallus	16-42
8232253-1	1993	The presence of fatty acid-binding protein (FABP) in the embryonic chick retina may be linked to the demand for polyunsaturated fatty acids in this developing neural tissue.	Fatty Acids, Unsaturated	112-139	fatty acid binding protein 1	Gallus gallus	44-48
8102769-5	1993	Thus, the profile of liver delta 6 desaturase activity after puberty was not related to age only; it also depended on the polyunsaturated fatty acid (PUFA) n-6 and n-3 balance in the diet.	Fatty Acids, Unsaturated	122-148	fatty acid desaturase 2	Rattus norvegicus	27-45
8102769-5	1993	Thus, the profile of liver delta 6 desaturase activity after puberty was not related to age only; it also depended on the polyunsaturated fatty acid (PUFA) n-6 and n-3 balance in the diet.	Fatty Acids, Unsaturated	150-154	fatty acid desaturase 2	Rattus norvegicus	27-45
8489510-9	1993	These results indicate the existence of an alternative pathway, involving delta 5-desaturase, which is the only route for PUFA biosynthesis in K562 cells.	Fatty Acids, Unsaturated	122-126	fatty acid desaturase 1	Homo sapiens	74-92
7683909-10	1993	Milk fat of DSS-dosed cows had a smaller proportion of short-chain fatty acids but a greater proportion of unsaturated fatty acids.	Fatty Acids, Unsaturated	107-130	Weaning weight-maternal milk	Bos taurus	0-4
8511883-4	1993	The findings suggest that the diet enriched in polyunsaturated fatty acids and antioxidants contributed to a decrease of LPO products content in the blood serum and apoB lipoproteins as well as to the inhibition of lipoprotein oxidation during their synthesis in liver cells; the diet may be recommended for the prophylaxis and treatment of atherosclerosis.	Fatty Acids, Unsaturated	47-74	apolipoprotein B	Oryctolagus cuniculus	165-169
8427602-5	1993	These results indicate that unsaturated fatty acids induce alterations in rABP steroid-binding properties that could modulate the endocrine function of rABP.	Fatty Acids, Unsaturated	28-51	sex hormone binding globulin	Rattus norvegicus	152-156
8418404-8	1993	CONCLUSIONS: Decreased insulin sensitivity is associated with decreased concentrations of polyunsaturated fatty acids in skeletal-muscle phospholipids, raising the possibility that changes in the fatty-acid composition of muscles modulate the action of insulin.	Fatty Acids, Unsaturated	90-117	insulin	Homo sapiens	23-30
1467525-7	1992	Mouse recombinant tumor necrosis factor-alpha (mr-TNF-alpha) significantly decreased the H-1 methyl and methylene lipid linewidths, and the C-13 spectra indicated a decrease in the relative concentration of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	207-234	tumor necrosis factor	Mus musculus	18-45
8490566-8	1993	Moreover macrophages from control rats fed an enriched polyunsaturated fatty acid diet had increased hexokinase activity (21%), decreased glutaminase (48%) and citrate synthase (decreased 41%) relative to the activities of these enzymes in macrophages of animals maintained on a balanced fatty acid diet.	Fatty Acids, Unsaturated	55-81	citrate synthase	Rattus norvegicus	160-176
8390886-9	1993	Polyunsaturated fatty acids at physiological concentrations are efficient activators of PPARs, and 5,8,11,14-eicosatetraynoic acid (ETYA), which is the alkyne homolog of arachidonic acid, is the most potent activator of xPPAR alpha described to date.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha L homeolog	Xenopus laevis	220-231
18475517-1	1993	The human parathyroid hormone N-terminal fragment [hPTH-(1-34)] increases the conversion of exogenous unsaturated fatty acids to prostaglandins (PGs) in calvarial homogenates.	Fatty Acids, Unsaturated	102-125	parathyroid hormone	Homo sapiens	10-29
1467525-7	1992	Mouse recombinant tumor necrosis factor-alpha (mr-TNF-alpha) significantly decreased the H-1 methyl and methylene lipid linewidths, and the C-13 spectra indicated a decrease in the relative concentration of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	207-234	tumor necrosis factor	Homo sapiens	50-59
1358207-0	1992	Arachidonic acid regulates unsaturated fatty acid synthesis in lymphocytes by inhibiting stearoyl-CoA desaturase gene expression.	Fatty Acids, Unsaturated	27-49	stearoyl-Coenzyme A desaturase 1	Mus musculus	89-112
1493107-1	1992	Incubation of murine macrophages or the macrophage-like cell line P388D with interferon-gamma in vitro induced a significant increase in the polyunsaturated fatty acid content of phosphatidylethanolamine.	Fatty Acids, Unsaturated	141-167	interferon gamma	Mus musculus	77-93
1321625-1	1992	Phospholipase A2 (PLA2) treatment of synaptosomal membranes, which causes the release of fatty acids, particularly unsaturated fatty acids, inhibits the flux of chloride ions through the gamma-aminobutyric acid (GABA) benzodiazepine receptor ion channel in response to activation by agonists.	Fatty Acids, Unsaturated	115-138	phospholipase A2 group IB	Homo sapiens	0-16
1480148-2	1992	Experimental studies with the small non-human primate marmoset monkey have clearly demonstrated the health benefit of substituting polyunsaturated fatty acids (PUFA"s) for dietary saturated fatty acids.	Fatty Acids, Unsaturated	131-158	pumilio RNA binding family member 3	Homo sapiens	160-164
1390591-9	1992	Similarly, the tissue-type plasminogen activator (t-PA) antigen level was lower in the aspirin + PUFA-treated group.	Fatty Acids, Unsaturated	97-101	plasminogen activator, tissue type	Homo sapiens	15-48
1390591-9	1992	Similarly, the tissue-type plasminogen activator (t-PA) antigen level was lower in the aspirin + PUFA-treated group.	Fatty Acids, Unsaturated	97-101	plasminogen activator, tissue type	Homo sapiens	50-54
1525046-0	1992	Polyunsaturated fatty acids decrease the apparent affinity of vitamin D metabolites for human vitamin D-binding protein.	Fatty Acids, Unsaturated	0-27	GC vitamin D binding protein	Homo sapiens	94-119
1320939-5	1992	Translocation of PAP-1 activity in the hepatocytes is preferentially promoted by unsaturated fatty acids (C18:1, C18:2, C18:3, C20:4 and C20:5), rather than by saturated acids (C14:0, C16:0, C18:0).	Fatty Acids, Unsaturated	81-104	regenerating family member 3 beta	Rattus norvegicus	17-22
1397836-4	1992	For example, fatty acid synthase gene transcription is inhibited by specific polyunsaturated fatty acids; S14 and pyruvate kinase genes contain a specific carbohydrate response element; and editing of apo B-100 to apo B-48 is enhanced by dietary carbohydrate.	Fatty Acids, Unsaturated	77-104	fatty acid synthase	Homo sapiens	13-32
1382421-3	1992	Using three in vitro models we observed these two compounds had inhibitory effects on cytochrome C reduction by ferrous iron, by ferrous iron accelerated by an unsaturated fatty acid or by epinephrine.	Fatty Acids, Unsaturated	160-182	cytochrome c, somatic	Homo sapiens	86-98
1324773-3	1992	Arachidonic acid, the major unsaturated fatty acid released by phospholipase A2, also inhibited muscimol-induced 36Cl uptake.	Fatty Acids, Unsaturated	28-50	phospholipase A2 group IB	Rattus norvegicus	63-79
1321625-1	1992	Phospholipase A2 (PLA2) treatment of synaptosomal membranes, which causes the release of fatty acids, particularly unsaturated fatty acids, inhibits the flux of chloride ions through the gamma-aminobutyric acid (GABA) benzodiazepine receptor ion channel in response to activation by agonists.	Fatty Acids, Unsaturated	115-138	phospholipase A2 group IB	Homo sapiens	18-22
1323857-3	1992	This nutritional observation prompted us to investigate in vitro the effects of varying concentrations of polyunsaturated fatty acids (PUFAs) on rat liver microsomal chain elongation of GLA into DGLA.	Fatty Acids, Unsaturated	106-133	galactosidase, alpha	Rattus norvegicus	186-189
1500589-7	1992	Concentrations of long-chain and unsaturated fatty acids in milk were increased slightly by bST and substantially with added fat.	Fatty Acids, Unsaturated	33-56	Weaning weight-maternal milk	Bos taurus	60-64
1500589-9	1992	Added unsaturated dietary fat coupled with bST increased milk yield and produced a greater concentration of unsaturated fatty acids in milk.	Fatty Acids, Unsaturated	108-131	Weaning weight-maternal milk	Bos taurus	135-139
1320551-0	1992	Polyunsaturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production.	Fatty Acids, Unsaturated	0-27	interleukin 2	Homo sapiens	89-102
1320551-15	1992	All polyunsaturated fatty acids tested caused a decrease in the concentration of interleukin-2; the greatest decrease (approximately 90%) was caused by eicosapentaenoate.	Fatty Acids, Unsaturated	4-31	interleukin 2	Homo sapiens	81-94
1323857-3	1992	This nutritional observation prompted us to investigate in vitro the effects of varying concentrations of polyunsaturated fatty acids (PUFAs) on rat liver microsomal chain elongation of GLA into DGLA.	Fatty Acids, Unsaturated	135-140	galactosidase, alpha	Rattus norvegicus	186-189
1546963-3	1992	Unsaturated fatty acids at microM concentrations inhibited protein synthesis in intact GH2 pituitary, C6 glial tumour and HeLa cells in a manner dependent on degree of unsaturation and cell number.	Fatty Acids, Unsaturated	0-23	growth hormone 2	Homo sapiens	87-90
1350282-8	1992	Furthermore, when the fat-free diet was supplemented with triacylglycerides containing polyunsaturated fatty acids, the transcription of the SCD1 gene and the induction of the SCD1 mRNA were significantly blunted.	Fatty Acids, Unsaturated	87-114	stearoyl-Coenzyme A desaturase 1	Mus musculus	141-145
1350282-8	1992	Furthermore, when the fat-free diet was supplemented with triacylglycerides containing polyunsaturated fatty acids, the transcription of the SCD1 gene and the induction of the SCD1 mRNA were significantly blunted.	Fatty Acids, Unsaturated	87-114	stearoyl-Coenzyme A desaturase 1	Mus musculus	176-180
1350282-11	1992	These data demonstrate that both dietary carbohydrates and polyunsaturated fatty acids or their metabolites directly or indirectly regulate the expression of the SCD1 gene in mouse liver.	Fatty Acids, Unsaturated	59-86	stearoyl-Coenzyme A desaturase 1	Mus musculus	162-166
1373954-1	1992	Previous in vitro studies have shown that unsaturated fatty acids (UFA) induce conformational changes in rodent and human alpha-fetoprotein (AFP).	Fatty Acids, Unsaturated	42-65	alpha fetoprotein	Homo sapiens	122-139
1373954-1	1992	Previous in vitro studies have shown that unsaturated fatty acids (UFA) induce conformational changes in rodent and human alpha-fetoprotein (AFP).	Fatty Acids, Unsaturated	42-65	alpha fetoprotein	Homo sapiens	141-144
1373954-1	1992	Previous in vitro studies have shown that unsaturated fatty acids (UFA) induce conformational changes in rodent and human alpha-fetoprotein (AFP).	Fatty Acids, Unsaturated	67-70	alpha fetoprotein	Homo sapiens	122-139
1373954-1	1992	Previous in vitro studies have shown that unsaturated fatty acids (UFA) induce conformational changes in rodent and human alpha-fetoprotein (AFP).	Fatty Acids, Unsaturated	67-70	alpha fetoprotein	Homo sapiens	141-144
1586937-7	1992	Since not only an activation of a phospholipase C but also an activation of a phospholipase A2 with subsequent generation of lysophospholipids and free fatty acids is reported to occur in glucose-induced insulin secretion, the interaction of the phospholipase C reaction product IP3 with a lysophospholipid or an unsaturated fatty acid may affect the extent and duration of the rise in the free cytoplasmic Ca2+ concentration responsible for initiation of insulin secretion.	Fatty Acids, Unsaturated	313-335	phospholipase A2, group IB, pancreas	Mus musculus	78-94
1328428-1	1992	The cyclooxygenase and lipoxygenase enzyme systems can metabolize a number of C20 polyunsaturated fatty acids.	Fatty Acids, Unsaturated	82-109	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	23-35
1556107-0	1992	Specificity of unsaturated fatty acid-regulated expression of the Saccharomyces cerevisiae OLE1 gene.	Fatty Acids, Unsaturated	15-37	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	91-95
1576365-7	1992	In particular, an increase in the cholesterol to phospholipid molar ratio and a decrease in polyunsaturated fatty acid content of phospholipids in erythrocyte membranes of cirrhotic patients was associated with impairments in insulin receptor processing.	Fatty Acids, Unsaturated	92-118	insulin receptor	Homo sapiens	226-242
1733503-7	1992	These results suggest that IMF-1 is an unsaturated fatty acid or an isoprenoid acid.	Fatty Acids, Unsaturated	39-61	platelet derived growth factor receptor beta	Homo sapiens	27-32
1636501-5	1992	In addition, end products of catalytic activity of PLA2 such as unsaturated fatty acids (arachidonic or oleic acids) mimicked the effect of PLA2.	Fatty Acids, Unsaturated	64-87	phospholipase A2 group IB	Rattus norvegicus	51-55
1636501-5	1992	In addition, end products of catalytic activity of PLA2 such as unsaturated fatty acids (arachidonic or oleic acids) mimicked the effect of PLA2.	Fatty Acids, Unsaturated	64-87	phospholipase A2 group IB	Rattus norvegicus	140-144
1460605-4	1992	Both, modifications in binding characteristics of ER and cleavage of the native 67 KDa receptor were found to be extremely marked when unsaturated fatty acids were directly added to the high-salt cell extracts.	Fatty Acids, Unsaturated	135-158	estrogen receptor 1	Homo sapiens	50-52
1449825-0	1992	LDL receptor-dependent polyunsaturated fatty acid transport and metabolism.	Fatty Acids, Unsaturated	23-49	low density lipoprotein receptor	Homo sapiens	0-12
1431424-0	1992	Effects of polyunsaturated fatty acids on interleukin-2-dependent T cell growth.	Fatty Acids, Unsaturated	11-38	interleukin 2	Mus musculus	42-55
1431424-5	1992	In this report we study the effects of the polyunsaturated fatty acids (PUFA) on proliferation and signal transduction in the interleukin-2 (IL-2)-dependent murine T cell line CTL.L-2.	Fatty Acids, Unsaturated	43-70	interleukin 2	Mus musculus	126-139
1431424-5	1992	In this report we study the effects of the polyunsaturated fatty acids (PUFA) on proliferation and signal transduction in the interleukin-2 (IL-2)-dependent murine T cell line CTL.L-2.	Fatty Acids, Unsaturated	43-70	interleukin 2	Mus musculus	141-145
1431424-5	1992	In this report we study the effects of the polyunsaturated fatty acids (PUFA) on proliferation and signal transduction in the interleukin-2 (IL-2)-dependent murine T cell line CTL.L-2.	Fatty Acids, Unsaturated	72-76	interleukin 2	Mus musculus	126-139
1431424-5	1992	In this report we study the effects of the polyunsaturated fatty acids (PUFA) on proliferation and signal transduction in the interleukin-2 (IL-2)-dependent murine T cell line CTL.L-2.	Fatty Acids, Unsaturated	72-76	interleukin 2	Mus musculus	141-145
1530793-15	1992	Furthermore, the release of the unsaturated fatty acid linoleic acid or its metabolites may be of functional importance in IL-1-mediated IL-2 production by EL-4 cells.	Fatty Acids, Unsaturated	32-54	interleukin 1 complex	Mus musculus	123-127
1530793-15	1992	Furthermore, the release of the unsaturated fatty acid linoleic acid or its metabolites may be of functional importance in IL-1-mediated IL-2 production by EL-4 cells.	Fatty Acids, Unsaturated	32-54	interleukin 2	Mus musculus	137-141
1460605-6	1992	Our observations are discussed in terms of possible interference of unsaturated fatty acids either through transmembrane modulation of phosphokinases and/or phospholipases implicated in ER mechanism of action, or through an intracellular interaction between ER and these acids acting as second messengers in regulation of cellular functions.	Fatty Acids, Unsaturated	68-91	estrogen receptor 1	Homo sapiens	186-188
1460605-6	1992	Our observations are discussed in terms of possible interference of unsaturated fatty acids either through transmembrane modulation of phosphokinases and/or phospholipases implicated in ER mechanism of action, or through an intracellular interaction between ER and these acids acting as second messengers in regulation of cellular functions.	Fatty Acids, Unsaturated	68-91	estrogen receptor 1	Homo sapiens	258-260
18475449-0	1992	Unsaturated fatty acids suppress interleukin-2 production and transferrin receptor expression by concanavalin A-stimulated rat Iymphocytes.	Fatty Acids, Unsaturated	0-23	interleukin 2	Rattus norvegicus	33-46
18475449-0	1992	Unsaturated fatty acids suppress interleukin-2 production and transferrin receptor expression by concanavalin A-stimulated rat Iymphocytes.	Fatty Acids, Unsaturated	0-23	transferrin	Rattus norvegicus	62-73
18475449-3	1992	We now report that unsaturated fatty acids decrease the concentration of interleukin-2 in the culture medium of such cells by up to 45%.	Fatty Acids, Unsaturated	19-42	interleukin 2	Rattus norvegicus	73-86
18475449-4	1992	This suggests that unsaturated fatty acids inhibit lymphocyte proliferation by suppressing interleukin-2 production.	Fatty Acids, Unsaturated	19-42	interleukin 2	Rattus norvegicus	91-104
18475449-5	1992	However, lymphocyte proliferation was only partially restored by addition of exogenous interleukin-2 to cell culture medium in the presence of unsaturated fatty acids, indicating that these fatty acids also affect other processes involved in the control of proliferation.	Fatty Acids, Unsaturated	143-166	interleukin 2	Rattus norvegicus	87-100
18475449-8	1992	In contrast, unsaturated fatty acids decreased expression of the transferrin receptor by up to 50%.	Fatty Acids, Unsaturated	13-36	transferrin	Rattus norvegicus	65-76
18475449-9	1992	These observations suggest that the mechanism by which unsaturated fatty acids inhibit lymphocyte proliferation involves suppression of interleukin-2 production and of transferrin receptor expression.	Fatty Acids, Unsaturated	55-78	interleukin 2	Rattus norvegicus	136-149
18475449-9	1992	These observations suggest that the mechanism by which unsaturated fatty acids inhibit lymphocyte proliferation involves suppression of interleukin-2 production and of transferrin receptor expression.	Fatty Acids, Unsaturated	55-78	transferrin	Rattus norvegicus	168-179
31071808-0	1991	Influence of Milk Fat Higher in Unsaturated Fatty Acids on the Accuracy of Milk Fat Analyses by the Mid-Infrared Spectroscopic Method.	Fatty Acids, Unsaturated	32-55	Weaning weight-maternal milk	Bos taurus	13-17
1659320-0	1991	Cytochrome P450 IIIA1 (P450p) requires cytochrome b5 and phospholipid with unsaturated fatty acids.	Fatty Acids, Unsaturated	75-98	cytochrome b5 type A	Rattus norvegicus	39-52
1955472-5	1991	Unsaturated fatty acid levels are substantially decreased in mdm2 cells after a prolonged incubation at the non-permissive temperature.	Fatty Acids, Unsaturated	0-22	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	61-65
1955472-7	1991	These results indicate that mdm2 is a temperature-sensitive allele of OLE1 and demonstrate an essential role for unsaturated fatty acids in mitochondrial movement and inheritance.	Fatty Acids, Unsaturated	113-136	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	28-32
1815240-6	1991	The results indicate that PIH is associated with a relative increased unsaturation of maternal serum PL, which might facilitate the placental transfer of long-chain, polyunsaturated fatty acids.	Fatty Acids, Unsaturated	166-193	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	26-29
1668121-0	1991	Platelet-activating factor and polyunsaturated fatty acids in cerebral ischemia or convulsions: intracellular PAF-binding sites and activation of a fos/jun/AP-1 transcriptional signaling system.	Fatty Acids, Unsaturated	31-58	PCNA clamp associated factor	Rattus norvegicus	110-113
1668121-0	1991	Platelet-activating factor and polyunsaturated fatty acids in cerebral ischemia or convulsions: intracellular PAF-binding sites and activation of a fos/jun/AP-1 transcriptional signaling system.	Fatty Acids, Unsaturated	31-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	148-151
1668121-0	1991	Platelet-activating factor and polyunsaturated fatty acids in cerebral ischemia or convulsions: intracellular PAF-binding sites and activation of a fos/jun/AP-1 transcriptional signaling system.	Fatty Acids, Unsaturated	31-58	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	156-160
1668121-2	1991	Free polyunsaturated fatty acids and arachidonic and docosahexaenoic acids are accumulated along with PAF.	Fatty Acids, Unsaturated	5-32	PCNA clamp associated factor	Rattus norvegicus	102-105
31071808-0	1991	Influence of Milk Fat Higher in Unsaturated Fatty Acids on the Accuracy of Milk Fat Analyses by the Mid-Infrared Spectroscopic Method.	Fatty Acids, Unsaturated	32-55	Weaning weight-maternal milk	Bos taurus	75-79
31071808-1	1991	An experiment was conducted to investigate the reliability of milk fat measurement by the mid-infrared spectroscopic method when analyzing milk fat containing greater than normal amounts of unsaturated fatty acids.	Fatty Acids, Unsaturated	190-213	Weaning weight-maternal milk	Bos taurus	62-66
31071808-4	1991	Unsaturated fatty acid percentages in milk fat were 25.0, 28.4, 39.6, and 37.9 for C, C+, Sun+, and Saff+ treatments, respectively.	Fatty Acids, Unsaturated	0-22	Weaning weight-maternal milk	Bos taurus	38-42
31071808-6	1991	Results indicate the mid-infrared spectroscopic method underestimates the fat content in milk which is higher in unsaturated fatty acids.	Fatty Acids, Unsaturated	113-136	Weaning weight-maternal milk	Bos taurus	89-93
31071808-8	1991	A possible remedy for this problem may be to have milk plants calibrate the mid-infrared spectroscopic instrument with milk samples containing higher than normal amounts of unsaturated fatty acids in milk fat.	Fatty Acids, Unsaturated	173-196	Weaning weight-maternal milk	Bos taurus	50-54
31071808-8	1991	A possible remedy for this problem may be to have milk plants calibrate the mid-infrared spectroscopic instrument with milk samples containing higher than normal amounts of unsaturated fatty acids in milk fat.	Fatty Acids, Unsaturated	173-196	Weaning weight-maternal milk	Bos taurus	119-123
31071808-8	1991	A possible remedy for this problem may be to have milk plants calibrate the mid-infrared spectroscopic instrument with milk samples containing higher than normal amounts of unsaturated fatty acids in milk fat.	Fatty Acids, Unsaturated	173-196	Weaning weight-maternal milk	Bos taurus	119-123
1807856-0	1991	Differential effects of unsaturated fatty acids on modulation of endotoxin-induced tissue factor activation in cultured human leukemia U937 cells.	Fatty Acids, Unsaturated	24-47	coagulation factor III, tissue factor	Homo sapiens	83-96
1720022-0	1991	Effect of alpha-fetoprotein and albumin on the uptake of polyunsaturated fatty acids by rat hepatoma cells and fetal rat hepatocytes.	Fatty Acids, Unsaturated	57-84	alpha-fetoprotein	Rattus norvegicus	10-27
1720022-1	1991	The uptake of polyunsaturated fatty acids by rat hepatoma cells and fetal hepatocytes has been studied using albumin and alpha-fetoprotein (AFP) as carrier proteins.	Fatty Acids, Unsaturated	14-41	alpha-fetoprotein	Rattus norvegicus	121-138
1720022-1	1991	The uptake of polyunsaturated fatty acids by rat hepatoma cells and fetal hepatocytes has been studied using albumin and alpha-fetoprotein (AFP) as carrier proteins.	Fatty Acids, Unsaturated	14-41	alpha-fetoprotein	Rattus norvegicus	140-143
1807856-7	1991	The results suggest that chronic exposure of U937 cells to unsaturated fatty acids leads to modulation of the TF-activation in response to LPS.	Fatty Acids, Unsaturated	59-82	coagulation factor III, tissue factor	Homo sapiens	110-112
1949072-1	1991	Micromolar concentrations of polyunsaturated fatty acids and ascorbate esters of saturated fatty acids were found to cause a marked inhibition of rat and mouse hepatic glutathione-S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene.	Fatty Acids, Unsaturated	29-56	hematopoietic prostaglandin D synthase	Mus musculus	168-193
1949072-1	1991	Micromolar concentrations of polyunsaturated fatty acids and ascorbate esters of saturated fatty acids were found to cause a marked inhibition of rat and mouse hepatic glutathione-S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene.	Fatty Acids, Unsaturated	29-56	hematopoietic prostaglandin D synthase	Mus musculus	195-198
1892890-7	1991	At low concentrations, unsaturated fatty acids also stimulated the CETP-mediated redistribution of radiolabeled cholesteryl esters from HDL3 to LDL.	Fatty Acids, Unsaturated	23-46	cholesteryl ester transfer protein	Homo sapiens	67-71
1716990-2	1991	They had differential inhibitory effects (NDGA greater than equol greater than enterolactone greater than enterodiol) on the binding of estrone and estradiol to rat AFP and the binding of unsaturated fatty acid to both rat and human AFP.	Fatty Acids, Unsaturated	188-210	alpha fetoprotein	Homo sapiens	233-236
1892890-7	1991	At low concentrations, unsaturated fatty acids also stimulated the CETP-mediated redistribution of radiolabeled cholesteryl esters from HDL3 to LDL.	Fatty Acids, Unsaturated	23-46	HDL3	Homo sapiens	136-140
2039470-2	1991	Addition of BSA or Ca2- to the incubation medium decreased the stimulating effects of the unsaturated fatty acids.	Fatty Acids, Unsaturated	90-113	carbonic anhydrase 2	Rattus norvegicus	19-22
1659156-2	1991	Enzymatic transformation of the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid (AA) by the 5-lipoxygenase (LO) enzyme results in the formation of leukotrienes (LTs) including leukotriene B4 (LTB4), which is a potent mediator of inflammation.	Fatty Acids, Unsaturated	64-68	arachidonate 5-lipoxygenase	Homo sapiens	99-113
1905534-5	1991	It would appear that the in vivo inhibition of fatty acid synthase gene expression by dietary polyunsaturated fatty acids is a specific hepatocelluar event.	Fatty Acids, Unsaturated	94-121	fatty acid synthase	Rattus norvegicus	47-66
1943494-0	1991	Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	68-94	fatty acid desaturase 1	Rattus norvegicus	46-64
1943494-10	1991	These results demonstrate that (+)-sesamin and related lignan compounds present in sesame seeds or its oil are specific inhibitors of delta 5 desaturase in polyunsaturated fatty acid biosynthesis in both microorganisms and animals.	Fatty Acids, Unsaturated	156-182	fatty acid desaturase 1	Rattus norvegicus	134-152
1903659-0	1991	Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin.	Fatty Acids, Unsaturated	46-68	linoleate 9S-lipoxygenase-4	Glycine max	8-20
31051561-3	1991	Utilization of feeding, genetic variation, and bovine somatotropin should produce a milk fat lower in saturated and higher in unsaturated fatty acids.	Fatty Acids, Unsaturated	126-149	somatotropin	Bos taurus	54-66
31051561-3	1991	Utilization of feeding, genetic variation, and bovine somatotropin should produce a milk fat lower in saturated and higher in unsaturated fatty acids.	Fatty Acids, Unsaturated	126-149	Weaning weight-maternal milk	Bos taurus	84-88
1709334-11	1991	The most notable difference is the strong preferential binding of polyunsaturated fatty acids by AFP.	Fatty Acids, Unsaturated	66-93	alpha fetoprotein	Homo sapiens	97-100
1900474-5	1991	It is possible that unsaturated fatty acids may take part in the activation of alpha- and beta-subspecies of PKC which are present in the presynaptic nerve endings terminating at the hippocampal pyramidal cells.	Fatty Acids, Unsaturated	20-43	protein kinase C, gamma	Rattus norvegicus	109-112
2010582-5	1991	Rats maintained on PUFA diets showed a marked increase in their adipose tissue lipoprotein lipase activity.	Fatty Acids, Unsaturated	19-23	lipoprotein lipase	Rattus norvegicus	79-97
2010582-6	1991	The fast removal of large chylomicrons and increased tissue lipoprotein lipase activity, together with suppression of hepatic lipogenesis on this diet, apparently explains the low plasma triglyceride level in rats maintained on diets rich in PUFAs.	Fatty Acids, Unsaturated	242-247	lipoprotein lipase	Rattus norvegicus	60-78
1904970-4	1991	The influence of these two diets on the delta 6 desaturase activity was investigated in the present study because the hepatic desaturase system is a source of unsaturated fatty acids.	Fatty Acids, Unsaturated	159-182	fatty acid desaturase 2	Rattus norvegicus	40-58
2013970-5	1991	Because these sites have different properties, PC-TP can discriminate between positional isomers of PC and displays a distinct preference for those molecular species that carry a polyunsaturated fatty acid chain at the sn-2-position.	Fatty Acids, Unsaturated	179-205	phosphatidylcholine transfer protein	Bos taurus	47-52
1843205-0	1991	Insulin sensitivity is increased in Friend erythroleukemia cells enriched in polyunsaturated fatty acid.	Fatty Acids, Unsaturated	77-103	insulin	Homo sapiens	0-7
1843205-6	1991	The affinity for insulin in the polyunsaturated fatty acid treated cells decreased, however, resulting in similar amounts of insulin binding at low insulin concentrations but more binding at high insulin concentrations when compared to control cells.	Fatty Acids, Unsaturated	32-58	insulin	Homo sapiens	17-24
1843205-6	1991	The affinity for insulin in the polyunsaturated fatty acid treated cells decreased, however, resulting in similar amounts of insulin binding at low insulin concentrations but more binding at high insulin concentrations when compared to control cells.	Fatty Acids, Unsaturated	32-58	insulin	Homo sapiens	125-132
1843205-6	1991	The affinity for insulin in the polyunsaturated fatty acid treated cells decreased, however, resulting in similar amounts of insulin binding at low insulin concentrations but more binding at high insulin concentrations when compared to control cells.	Fatty Acids, Unsaturated	32-58	insulin	Homo sapiens	125-132
1843205-6	1991	The affinity for insulin in the polyunsaturated fatty acid treated cells decreased, however, resulting in similar amounts of insulin binding at low insulin concentrations but more binding at high insulin concentrations when compared to control cells.	Fatty Acids, Unsaturated	32-58	insulin	Homo sapiens	125-132
2175783-1	1990	The objective of this research was to determine whether dietary polyunsaturated fatty acids suppress hepatic fatty acid synthase (FAS) mRNA levels by altering FAS gene transcription.	Fatty Acids, Unsaturated	64-91	fatty acid synthase	Rattus norvegicus	109-128
2175783-1	1990	The objective of this research was to determine whether dietary polyunsaturated fatty acids suppress hepatic fatty acid synthase (FAS) mRNA levels by altering FAS gene transcription.	Fatty Acids, Unsaturated	64-91	fatty acid synthase	Rattus norvegicus	130-133
2175783-1	1990	The objective of this research was to determine whether dietary polyunsaturated fatty acids suppress hepatic fatty acid synthase (FAS) mRNA levels by altering FAS gene transcription.	Fatty Acids, Unsaturated	64-91	fatty acid synthase	Rattus norvegicus	159-162
1978720-1	1990	Strains of Saccharomyces cerevisiae bearing the ole1 mutation are defective in unsaturated fatty acid (UFA) synthesis and require UFAs for growth.	Fatty Acids, Unsaturated	79-101	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	48-52
1978720-1	1990	Strains of Saccharomyces cerevisiae bearing the ole1 mutation are defective in unsaturated fatty acid (UFA) synthesis and require UFAs for growth.	Fatty Acids, Unsaturated	103-106	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	48-52
2271633-1	1990	Human neutrophil elastase (HNE) can be inhibited by unsaturated fatty acids, including oleic acid [Ashe, B. M., & Zimmerman, M. (1977) Biochem.	Fatty Acids, Unsaturated	52-75	elastase, neutrophil expressed	Homo sapiens	6-25
2118348-6	1990	These results show that SMLCK is directly inhibited by unsaturated fatty acids including AA.	Fatty Acids, Unsaturated	55-78	myosin light chain kinase	Homo sapiens	24-29
2371287-3	1990	In contrast, in the presence of micrograms/ml concentrations of polyunsaturated fatty acids (PUFAs), picomolar concentrations of TGF-beta 1 irreversibly inhibited the serum-free growth of A549 or B16 cells by 90-100%.	Fatty Acids, Unsaturated	64-91	transforming growth factor beta 1	Homo sapiens	129-139
2371287-3	1990	In contrast, in the presence of micrograms/ml concentrations of polyunsaturated fatty acids (PUFAs), picomolar concentrations of TGF-beta 1 irreversibly inhibited the serum-free growth of A549 or B16 cells by 90-100%.	Fatty Acids, Unsaturated	93-98	transforming growth factor beta 1	Homo sapiens	129-139
2371287-6	1990	Inhibition of A549 or B16 cell growth by TGF-beta 1 in the presence of PUFAs was almost completely reversed by the antioxidant vitamin E, suggesting a role for lipid peroxidation in this process.	Fatty Acids, Unsaturated	71-76	transforming growth factor beta 1	Homo sapiens	41-51
1693077-11	1990	These data indicate a strong influence on PAF biosynthesis of the products of the phospholipase A2 reaction, with lyso-PAF disposal being a critical event for PAF formation, and unsaturated fatty acids acting as feed-back inhibitors.	Fatty Acids, Unsaturated	178-201	phospholipase A2 group IB	Homo sapiens	82-98
1983460-4	1990	It is postulated that the increase of polyunsaturated fatty acids, stimulated the GGTP activity as a way of increasing substrate bioavailability for synthesis de novo of liver GSH, necessary for the protection of the hydroperoxides formation, attributed to the increment of polyunsaturated acids at cellular level.	Fatty Acids, Unsaturated	38-65	gamma-glutamyltransferase 1	Rattus norvegicus	82-86
2366627-0	1990	Phospholipase A activity of cultured rat ventricular myocyte is affected by the nature of cellular polyunsaturated fatty acids.	Fatty Acids, Unsaturated	99-126	phospholipase A and acyltransferase 1	Rattus norvegicus	0-15
1965301-1	1990	It is shown that the interaction of Ca precipitate of double stranded RNA, DNA, including the reconstructed in nucleosome structures DNA with L-cells plasmatic membrane surface induced the increase of cyclic AMP content, stimulates calcium ion input as well the activity of phospholipase A2, resulting in increase of the phospholipid lysoform and unsaturated fatty acid level in membrane, providing the possibility of nucleic acid biopolymer translocation into cell.	Fatty Acids, Unsaturated	347-369	phospholipase A2 group IB	Homo sapiens	274-290
2303061-3	1990	S-thiolation of L-FABP by glutathione decreased the affinity of the protein for unsaturated fatty acids without changing the equimolar maximum binding.	Fatty Acids, Unsaturated	80-103	fatty acid binding protein 1	Rattus norvegicus	16-22
2303061-6	1990	The binding affinity of L-FABP for unsaturated fatty acid may be regulated by redox state of the liver.	Fatty Acids, Unsaturated	35-57	fatty acid binding protein 1	Rattus norvegicus	24-30
2159804-0	1990	Binding of unsaturated fatty acids to Na+, K(+)-ATPase leading to inhibition and inactivation.	Fatty Acids, Unsaturated	11-34	dynein axonemal heavy chain 8	Homo sapiens	48-54
2334442-1	1990	Dietary polyunsaturated fatty acid is needed for optimal induction of cytochrome P450.	Fatty Acids, Unsaturated	8-34	hydroperoxide lyase 1	Zea mays	81-85
33774033-0	2021	Can polyunsaturated fatty acids regulate Polycystic Ovary Syndrome via TGF-beta signalling?	Fatty Acids, Unsaturated	4-31	transforming growth factor alpha	Homo sapiens	71-79
33774033-5	2021	Studies show that the consumption of polyunsaturated fatty acids (PUFAs) regulates menstrual cycle, decrease testosterone and insulin levels, and improve metabolic health.	Fatty Acids, Unsaturated	37-64	insulin	Homo sapiens	126-133
33774033-5	2021	Studies show that the consumption of polyunsaturated fatty acids (PUFAs) regulates menstrual cycle, decrease testosterone and insulin levels, and improve metabolic health.	Fatty Acids, Unsaturated	66-71	insulin	Homo sapiens	126-133
33804804-6	2021	In the last section, we introduce the association of polyunsaturated fatty acids and cellular chaperones of fatty acid-binding protein 3 in the context of nicotine-induced addiction in the mouse nucleus accumbens and provide a novel target for the treatment of drug abuse affecting dopaminergic systems.	Fatty Acids, Unsaturated	53-80	fatty acid binding protein 3, muscle and heart	Mus musculus	108-136
33939797-1	2021	Polyunsaturated fatty acids (PUFAs), but not saturated fatty acids, modulate ion channels such as the cardiac KCNQ1 channel, although the mechanism is not completely understood.	Fatty Acids, Unsaturated	0-27	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	110-115
33939797-1	2021	Polyunsaturated fatty acids (PUFAs), but not saturated fatty acids, modulate ion channels such as the cardiac KCNQ1 channel, although the mechanism is not completely understood.	Fatty Acids, Unsaturated	29-34	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	110-115
33805987-0	2021	Interaction of Lactoferrin with Unsaturated Fatty Acids: In Vitro and In Vivo Study of Human Lactoferrin/Oleic Acid Complex Cytotoxicity.	Fatty Acids, Unsaturated	32-55	lactotransferrin	Mus musculus	15-26
33805987-0	2021	Interaction of Lactoferrin with Unsaturated Fatty Acids: In Vitro and In Vivo Study of Human Lactoferrin/Oleic Acid Complex Cytotoxicity.	Fatty Acids, Unsaturated	32-55	lactotransferrin	Mus musculus	93-104
23213321-2	2012	PPARgamma can be activated by a diverse group of agents, such as endogenous polyunsaturated fatty acids, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), and thiazolidinedione (TZD) drugs.	Fatty Acids, Unsaturated	76-103	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
33801246-8	2021	In addition, the knockdown of HPS/FGL1 in SUIT-2 cells significantly increased omega-3 polyunsaturated fatty acids (PUFAs) and EPA production but not docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	116-121	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	Homo sapiens	30-33
33801246-8	2021	In addition, the knockdown of HPS/FGL1 in SUIT-2 cells significantly increased omega-3 polyunsaturated fatty acids (PUFAs) and EPA production but not docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	116-121	fibrinogen like 1	Homo sapiens	34-38
32860273-1	2020	Interphotoreceptor retinoid-binding protein (IRBP) is a highly expressed protein secreted by rod and cone photoreceptors that has major roles in photoreceptor homeostasis as well as retinoid and polyunsaturated fatty acid transport between the neural retina and retinal pigment epithelium.	Fatty Acids, Unsaturated	195-221	retinol binding protein 3	Bos taurus	0-43
32860273-1	2020	Interphotoreceptor retinoid-binding protein (IRBP) is a highly expressed protein secreted by rod and cone photoreceptors that has major roles in photoreceptor homeostasis as well as retinoid and polyunsaturated fatty acid transport between the neural retina and retinal pigment epithelium.	Fatty Acids, Unsaturated	195-221	retinol binding protein 3	Bos taurus	45-49
33034612-1	2020	Bovine alpha-lactalbumin (BLA) and beta-lactoglobulin (BLG) are the most common and severe food allergens in milk and they can bind C18 unsaturated fatty acids (UFAs) and their bioactivities were changed.	Fatty Acids, Unsaturated	161-165	lactalbumin alpha	Bos taurus	7-24
33034612-1	2020	Bovine alpha-lactalbumin (BLA) and beta-lactoglobulin (BLG) are the most common and severe food allergens in milk and they can bind C18 unsaturated fatty acids (UFAs) and their bioactivities were changed.	Fatty Acids, Unsaturated	161-165	beta-lactoglobulin	Bos taurus	35-53
33034612-1	2020	Bovine alpha-lactalbumin (BLA) and beta-lactoglobulin (BLG) are the most common and severe food allergens in milk and they can bind C18 unsaturated fatty acids (UFAs) and their bioactivities were changed.	Fatty Acids, Unsaturated	161-165	beta-lactoglobulin	Bos taurus	55-58
33034612-2	2020	This study aims to determine the effects of C18 UFAs on the structures of BLA and BLG and their allergic properties, such as antigenicity and allergenicity.	Fatty Acids, Unsaturated	48-52	beta-lactoglobulin	Bos taurus	82-85
23304111-2	2012	Liver PPAR-alpha downregulation with parallel PPAR-gamma and SREBP-1c up-regulation may trigger major metabolic disturbances between de novo lipogenesis and fatty acid oxidation favouring the former, in association with the onset of steatosis in obesity-induced oxidative stress and related long-chain polyunsaturated fatty acid n-3 (LCPUFA n-3) depletion, insulin resistance, hypoadiponectinemia, and endoplasmic reticulum stress.	Fatty Acids, Unsaturated	302-328	peroxisome proliferator activated receptor alpha	Homo sapiens	6-16
23214138-1	2012	Polyunsaturated fatty acids omega-3 (PUFA omega-3), in particular eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), are bioactive lipids that positively impact signaling pathways involved in the development of cardiovascular diseases.	Fatty Acids, Unsaturated	0-27	pumilio RNA binding family member 3	Homo sapiens	37-41
34455321-5	2022	Besides, fish oil constituents, such as polyunsaturated fatty acids (PUFAs), regulate various signaling pathways, such as nuclear factor kappa B pathway, Toll-like receptor pathway, transforming growth factor-beta (TGF-beta) pathway, and peroxisome proliferators activated receptor (PPAR) pathways.	Fatty Acids, Unsaturated	40-67	tumor necrosis factor	Homo sapiens	182-213
21549173-1	2011	Long chain polyunsaturated fatty acids (LC-PUFA), ARA (arachidonic acid, 20:4n-6) and DHA (docosahexaenoic acid, 22:6n-3) have positive effects and environment pollutants, polychlorinated dibenzo-p-dioxins/dibenzofurans(PCDD/F) and polychlorinated biphenyls (PCB) have negative effects on neural development during early life.	Fatty Acids, Unsaturated	11-38	pumilio RNA binding family member 3	Homo sapiens	43-47
14558821-8	2003	On the other hand, from the (13)C-T(1) measurements for trehalose, the T(1) values of the C-3 (C-3") and C-6" (C-6) are found to change remarkably by addition of UFA.	Fatty Acids, Unsaturated	162-165	complement C3	Homo sapiens	90-93
14558821-8	2003	On the other hand, from the (13)C-T(1) measurements for trehalose, the T(1) values of the C-3 (C-3") and C-6" (C-6) are found to change remarkably by addition of UFA.	Fatty Acids, Unsaturated	162-165	complement C3	Homo sapiens	95-98
14558821-8	2003	On the other hand, from the (13)C-T(1) measurements for trehalose, the T(1) values of the C-3 (C-3") and C-6" (C-6) are found to change remarkably by addition of UFA.	Fatty Acids, Unsaturated	162-165	complement C6	Homo sapiens	105-114
34902567-0	2022	Regioselectivity of an arachidonate 9S-lipoxygenase from Sphingopyxis macrogoltabida that biosynthesizes 9S,15S- and 11S,17S-dihydroxy fatty acids from C20 and C22 polyunsaturated fatty acids.	Fatty Acids, Unsaturated	164-191	Sp7 transcription factor 7	Mus musculus	160-163
34902567-4	2022	The enzyme catalyzed oxygenation at the n-12 position of C20 and C22 polyunsaturated fatty acids (PUFAs) to form 9S- and 11S-hydroperoxy fatty acids, which were reduced to 9S- and 11S-hydroxy fatty acids (HFAs) by cysteine, respectively, and it catalyzed again oxygenation at the n-6 position of HFAs to form 9S,15S- and 11S,17S-DiHFAs, respectively.	Fatty Acids, Unsaturated	69-96	Sp7 transcription factor 7	Mus musculus	65-68
34902567-4	2022	The enzyme catalyzed oxygenation at the n-12 position of C20 and C22 polyunsaturated fatty acids (PUFAs) to form 9S- and 11S-hydroperoxy fatty acids, which were reduced to 9S- and 11S-hydroxy fatty acids (HFAs) by cysteine, respectively, and it catalyzed again oxygenation at the n-6 position of HFAs to form 9S,15S- and 11S,17S-DiHFAs, respectively.	Fatty Acids, Unsaturated	98-103	Sp7 transcription factor 7	Mus musculus	65-68
34455321-5	2022	Besides, fish oil constituents, such as polyunsaturated fatty acids (PUFAs), regulate various signaling pathways, such as nuclear factor kappa B pathway, Toll-like receptor pathway, transforming growth factor-beta (TGF-beta) pathway, and peroxisome proliferators activated receptor (PPAR) pathways.	Fatty Acids, Unsaturated	40-67	transforming growth factor alpha	Homo sapiens	215-223
34455321-5	2022	Besides, fish oil constituents, such as polyunsaturated fatty acids (PUFAs), regulate various signaling pathways, such as nuclear factor kappa B pathway, Toll-like receptor pathway, transforming growth factor-beta (TGF-beta) pathway, and peroxisome proliferators activated receptor (PPAR) pathways.	Fatty Acids, Unsaturated	40-67	peroxisome proliferator activated receptor alpha	Homo sapiens	238-281
34455321-5	2022	Besides, fish oil constituents, such as polyunsaturated fatty acids (PUFAs), regulate various signaling pathways, such as nuclear factor kappa B pathway, Toll-like receptor pathway, transforming growth factor-beta (TGF-beta) pathway, and peroxisome proliferators activated receptor (PPAR) pathways.	Fatty Acids, Unsaturated	40-67	peroxisome proliferator activated receptor alpha	Homo sapiens	283-287
34455321-5	2022	Besides, fish oil constituents, such as polyunsaturated fatty acids (PUFAs), regulate various signaling pathways, such as nuclear factor kappa B pathway, Toll-like receptor pathway, transforming growth factor-beta (TGF-beta) pathway, and peroxisome proliferators activated receptor (PPAR) pathways.	Fatty Acids, Unsaturated	69-74	tumor necrosis factor	Homo sapiens	182-213
34455321-5	2022	Besides, fish oil constituents, such as polyunsaturated fatty acids (PUFAs), regulate various signaling pathways, such as nuclear factor kappa B pathway, Toll-like receptor pathway, transforming growth factor-beta (TGF-beta) pathway, and peroxisome proliferators activated receptor (PPAR) pathways.	Fatty Acids, Unsaturated	69-74	transforming growth factor alpha	Homo sapiens	215-223
34455321-5	2022	Besides, fish oil constituents, such as polyunsaturated fatty acids (PUFAs), regulate various signaling pathways, such as nuclear factor kappa B pathway, Toll-like receptor pathway, transforming growth factor-beta (TGF-beta) pathway, and peroxisome proliferators activated receptor (PPAR) pathways.	Fatty Acids, Unsaturated	69-74	peroxisome proliferator activated receptor alpha	Homo sapiens	238-281
34455321-5	2022	Besides, fish oil constituents, such as polyunsaturated fatty acids (PUFAs), regulate various signaling pathways, such as nuclear factor kappa B pathway, Toll-like receptor pathway, transforming growth factor-beta (TGF-beta) pathway, and peroxisome proliferators activated receptor (PPAR) pathways.	Fatty Acids, Unsaturated	69-74	peroxisome proliferator activated receptor alpha	Homo sapiens	283-287
34732836-1	2022	BACKGROUND/OBJECTIVES: Oxylipins are polyunsaturated fatty acid derivatives involved in the regulation of various processes, including chronic inflammation, insulin resistance and hepatic steatosis.	Fatty Acids, Unsaturated	37-63	insulin	Homo sapiens	157-164
34972124-7	2021	This was accompanied by reduced accumulation of SCD1-produced unsaturated fatty acids.	Fatty Acids, Unsaturated	62-85	stearoyl-Coenzyme A desaturase 1	Mus musculus	48-52
34951653-10	2022	Adipocyte Angptl3 (but not Angptl4) mRNA expression was inhibited by the polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid, whereas nine types of dietary fatty acids remained without any effect.	Fatty Acids, Unsaturated	73-100	angiopoietin-like 3	Mus musculus	10-17
34961526-3	2021	We also reported that a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could be activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon-like peptide-1 (GLP-1).	Fatty Acids, Unsaturated	129-156	free fatty acid receptor 4	Mus musculus	37-43
34961526-3	2021	We also reported that a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could be activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon-like peptide-1 (GLP-1).	Fatty Acids, Unsaturated	129-156	free fatty acid receptor 4	Mus musculus	45-71
34961526-3	2021	We also reported that a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could be activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon-like peptide-1 (GLP-1).	Fatty Acids, Unsaturated	129-156	glucagon	Mus musculus	196-219
34961526-3	2021	We also reported that a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could be activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon-like peptide-1 (GLP-1).	Fatty Acids, Unsaturated	129-156	glucagon	Mus musculus	221-226
34961526-3	2021	We also reported that a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could be activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon-like peptide-1 (GLP-1).	Fatty Acids, Unsaturated	158-162	free fatty acid receptor 4	Mus musculus	37-43
34961526-3	2021	We also reported that a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could be activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon-like peptide-1 (GLP-1).	Fatty Acids, Unsaturated	158-162	free fatty acid receptor 4	Mus musculus	45-71
34961526-3	2021	We also reported that a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could be activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon-like peptide-1 (GLP-1).	Fatty Acids, Unsaturated	158-162	glucagon	Mus musculus	196-219
34961526-3	2021	We also reported that a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could be activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon-like peptide-1 (GLP-1).	Fatty Acids, Unsaturated	158-162	glucagon	Mus musculus	221-226
34817231-6	2021	IMPORTANCE The oleate hydratase protein family was discovered in commensal bacteria that utilize host unsaturated fatty acids as the substrates to produce a spectrum of hydroxylated products.	Fatty Acids, Unsaturated	102-125	AT695_RS03350	Staphylococcus aureus	15-31
34817231-9	2021	S. aureus expresses an OhyA that produces at least three 10-hydroxy fatty acids from host unsaturated fatty acids at the infection site, and an S. aureus strain lacking the ohyA gene has compromised virulence in an immunocompetent infection model.	Fatty Acids, Unsaturated	90-113	AT695_RS03350	Staphylococcus aureus	23-27
34871448-14	2022	Supplementation with omega-3 polyunsaturated fatty acids (PUFAs) resulted in decreased concentrations of fluorescent AGEs and decreased expression of RAGE as well as increased expression of AGER1.	Fatty Acids, Unsaturated	58-63	advanced glycosylation end-product specific receptor	Homo sapiens	150-154
34977220-0	2021	Interference With ACSL1 Gene in Bovine Adipocytes: Transcriptome Profiling of mRNA and lncRNA Related to Unsaturated Fatty Acid Synthesis.	Fatty Acids, Unsaturated	105-127	fatty-acid-Coenzyme A ligase long chain 2	Bos taurus	18-23
34977220-2	2021	The ACSL1 gene controls unsaturated fatty acid (UFA) synthesis as well as the formation of lipid droplets in bovine adipocytes.	Fatty Acids, Unsaturated	24-46	fatty-acid-Coenzyme A ligase long chain 2	Bos taurus	4-9
34977220-2	2021	The ACSL1 gene controls unsaturated fatty acid (UFA) synthesis as well as the formation of lipid droplets in bovine adipocytes.	Fatty Acids, Unsaturated	48-51	fatty-acid-Coenzyme A ligase long chain 2	Bos taurus	4-9
34948014-0	2021	Salt-Sensitive Hypertension in GR+/- Rats Is Accompanied with Dysregulation in Adrenal Soluble Epoxide Hydrolase and Polyunsaturated Fatty Acid Pathways.	Fatty Acids, Unsaturated	117-143	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	31-33
34871448-14	2022	Supplementation with omega-3 polyunsaturated fatty acids (PUFAs) resulted in decreased concentrations of fluorescent AGEs and decreased expression of RAGE as well as increased expression of AGER1.	Fatty Acids, Unsaturated	58-63	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	190-195
34856889-2	2021	The natural compounds such as omega-3 (omega-3) polyunsaturated fatty acids (PUFAs), which can access blood-brain barrier, are believed to be potential disruptors of preformed Abeta fibrils to cure AD with unknown mechanism.	Fatty Acids, Unsaturated	77-82	amyloid beta precursor protein	Homo sapiens	176-181
34476741-13	2021	During cell reprogramming, c-MYC-dependent lipid remodelling leads to Polyunsaturated Fatty Acid (PUFA) downregulation and Monounsaturated Fatty Acid (MUFA) upregulation, which may play critical roles in cytoarchitectural remodelling of cell membrane or non-canonical autophagy, respectively.	Fatty Acids, Unsaturated	70-96	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	27-32
34719812-4	2021	In contrast, Ca+2 -independent PLA2 (iPLA2) and anti-inflammatory omega-3 docosahexaenoic acid (DHA), a polyunsaturated fatty acid believed to be primarily regulated by iPLA2, are diminished.	Fatty Acids, Unsaturated	104-130	phospholipase A2 group VI	Rattus norvegicus	169-174
34876760-4	2022	Polyunsaturated fatty acids control protein complex formation in lipid rafts associated with the function of two SARS-CoV-2 entry gateways: angiotensin-converting enzyme-2 and cellular protease transmembrane protease serine-2.	Fatty Acids, Unsaturated	0-27	angiotensin converting enzyme 2	Homo sapiens	140-171
34876760-4	2022	Polyunsaturated fatty acids control protein complex formation in lipid rafts associated with the function of two SARS-CoV-2 entry gateways: angiotensin-converting enzyme-2 and cellular protease transmembrane protease serine-2.	Fatty Acids, Unsaturated	0-27	transmembrane serine protease 2	Homo sapiens	194-225
33682565-1	2021	Human Cytochrome P450 2J2 (CYP2J2) as an important metabolic enzyme, plays a crucial role in metabolism of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	107-134	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	6-25
33682565-1	2021	Human Cytochrome P450 2J2 (CYP2J2) as an important metabolic enzyme, plays a crucial role in metabolism of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	107-134	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	27-33
33682565-1	2021	Human Cytochrome P450 2J2 (CYP2J2) as an important metabolic enzyme, plays a crucial role in metabolism of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	136-141	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	6-25
33682565-1	2021	Human Cytochrome P450 2J2 (CYP2J2) as an important metabolic enzyme, plays a crucial role in metabolism of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	136-141	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	27-33
34731738-7	2021	The estimated activity of Delta9-desaturase (C16:0), Delta5+Delta6-desaturase on both polyunsaturated fatty acid n-6 and n-3 linearly increased (P < 0.05) as affected by dietary TML.	Fatty Acids, Unsaturated	86-112	acyl-CoA 6-desaturase	Coturnix japonica	66-77
34476741-13	2021	During cell reprogramming, c-MYC-dependent lipid remodelling leads to Polyunsaturated Fatty Acid (PUFA) downregulation and Monounsaturated Fatty Acid (MUFA) upregulation, which may play critical roles in cytoarchitectural remodelling of cell membrane or non-canonical autophagy, respectively.	Fatty Acids, Unsaturated	98-102	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	27-32
34831370-10	2021	Our data support the neuroprotective role of PUFA n3 by targeting the NLRP3 inflammasome.	Fatty Acids, Unsaturated	45-49	NLR family, pyrin domain containing 3	Rattus norvegicus	70-75
34838055-1	2021	15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been proposed recently as a new molecular target for regulating cancer cell growth.	Fatty Acids, Unsaturated	64-87	arachidonate 15-lipoxygenase	Homo sapiens	0-15
34834018-9	2021	Moreover, consistent results from in vitro as well as in vivo experiments suggest that the inhibition of fat accumulation by miR-370-3p may result from the inhibition of saturated fatty acids that promote the accumulation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	225-252	CD36 molecule	Mus musculus	105-108
34813379-1	2022	It is well established that diets containing an increased omega-6 polyunsaturated fatty acid (n-6 PUFA) to omega-3 polyunsaturated fatty acid (n-3 PUFA) ratios are linked to inflammation and chronic diseases such as nonalcoholic fatty liver disease (NAFLD).	Fatty Acids, Unsaturated	115-141	pumilio RNA binding family member 3	Homo sapiens	98-102
34813379-1	2022	It is well established that diets containing an increased omega-6 polyunsaturated fatty acid (n-6 PUFA) to omega-3 polyunsaturated fatty acid (n-3 PUFA) ratios are linked to inflammation and chronic diseases such as nonalcoholic fatty liver disease (NAFLD).	Fatty Acids, Unsaturated	115-141	pumilio RNA binding family member 3	Homo sapiens	147-151
34801692-2	2022	Omega-3 polyunsaturated fatty acids (PUFAs) are key ingredients for maintaining cellular functions and improving insulin sensitivity.	Fatty Acids, Unsaturated	37-42	insulin	Homo sapiens	113-120
34741281-4	2022	Results indicated that leptin ( +) pigs had elevated leptin protein and mRNA expression levels and exhibited sluggish growth and development followed by decreased subcutaneous fat thickness, low serum triglycerides, saturated, unsaturated fatty acids and high cholesterol esters (p < 0.05).	Fatty Acids, Unsaturated	227-250	leptin	Sus scrofa	23-29
34557909-2	2021	Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain.	Fatty Acids, Unsaturated	67-94	sortilin 1	Homo sapiens	0-8
34322908-8	2021	Fascinatingly, the peroxisome elongation caused either due to silencing of DRP1 or by addition of polyunsaturated fatty acid, docosahexaenoic acid was blocked by overexpressing MAPL in mammalian cell lines.	Fatty Acids, Unsaturated	98-124	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	177-181
34298481-1	2021	OBJECTIVES: Chronic low-grade inflammation in obesity is partly driven by inflammatory cross talk between adipocytes and interferon-gamma-secreting CD4+ T-helper (Th)1 cells, a process we have shown may be mitigated by long-chain (LC) omega-3 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	272-277	interferon gamma	Mus musculus	121-137
34298481-1	2021	OBJECTIVES: Chronic low-grade inflammation in obesity is partly driven by inflammatory cross talk between adipocytes and interferon-gamma-secreting CD4+ T-helper (Th)1 cells, a process we have shown may be mitigated by long-chain (LC) omega-3 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	272-277	CD4 antigen	Mus musculus	148-151
34827853-5	2021	The lambs fed the SS diet showed a higher polyunsaturated fatty acid (PUFA) content than the lambs fed the WS diet (p < 0.01); there was no significant difference in growth performance and carcass characteristics between DP and TH lambs (p > 0.05).	Fatty Acids, Unsaturated	42-68	PUFA	Ovis aries	70-74
34831185-4	2021	The high levels of polyunsaturated fatty acids (PUFA) in the central nervous system (CNS) have led to studies centered on phospholipases A2 (PLA2s), enzymes responsible for cleaving the acyl groups at the sn-2 position of the phospholipids and resulting in production of PUFA and lysophospholipids.	Fatty Acids, Unsaturated	19-46	phospholipase A2 group IIA	Homo sapiens	141-146
34831185-4	2021	The high levels of polyunsaturated fatty acids (PUFA) in the central nervous system (CNS) have led to studies centered on phospholipases A2 (PLA2s), enzymes responsible for cleaving the acyl groups at the sn-2 position of the phospholipids and resulting in production of PUFA and lysophospholipids.	Fatty Acids, Unsaturated	48-52	phospholipase A2 group IIA	Homo sapiens	141-146
34670012-2	2022	We have found that polyunsaturated fatty acid eicosapentaenoic acid (EPA) downregulates Selenop expression by inactivating SREBP-1c.	Fatty Acids, Unsaturated	19-45	sterol regulatory element binding transcription factor 1	Homo sapiens	123-131
34665617-0	2021	alphaS Oligomers Generated from Interactions with a Polyunsaturated Fatty Acid and a Dopamine Metabolite Differentially Interact with Abeta to Enhance Neurotoxicity.	Fatty Acids, Unsaturated	52-78	amyloid beta precursor protein	Homo sapiens	134-139
34601049-2	2021	We have previously shown that the ACSL1 gene regulates the composition of unsaturated fatty acids (UFAs) in bovine skeletal muscle, which in turn regulates the fatty acid synthesis and the generation of lipid droplets.	Fatty Acids, Unsaturated	74-97	fatty-acid-Coenzyme A ligase long chain 2	Bos taurus	34-39
34601049-2	2021	We have previously shown that the ACSL1 gene regulates the composition of unsaturated fatty acids (UFAs) in bovine skeletal muscle, which in turn regulates the fatty acid synthesis and the generation of lipid droplets.	Fatty Acids, Unsaturated	99-103	fatty-acid-Coenzyme A ligase long chain 2	Bos taurus	34-39
34655995-1	2021	12/15-lipoxygenase (12/15-LOX) plays an essential role in oxidative conversion of polyunsaturated fatty acids into various bioactive lipid molecules.	Fatty Acids, Unsaturated	82-109	arachidonate 15-lipoxygenase	Homo sapiens	0-18
34655995-1	2021	12/15-lipoxygenase (12/15-LOX) plays an essential role in oxidative conversion of polyunsaturated fatty acids into various bioactive lipid molecules.	Fatty Acids, Unsaturated	82-109	arachidonate 15-lipoxygenase	Homo sapiens	20-29
34438249-1	2021	Delta-5 desaturase (D5D) is a rate-limiting enzyme that introduces double-bonds to the delta-5 position of the n-3 and n-6 polyunsaturated fatty acid chain.	Fatty Acids, Unsaturated	123-149	fatty acid desaturase 1	Homo sapiens	0-18
34682732-0	2021	Partial Replacement of Dietary Fat with Polyunsaturated Fatty Acids Attenuates the Lipopolysaccharide-Induced Hepatic Inflammation in Sprague-Dawley Rats Fed a High-Fat Diet.	Fatty Acids, Unsaturated	40-67	FAT atypical cadherin 1	Rattus norvegicus	165-168
34557909-2	2021	Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain.	Fatty Acids, Unsaturated	67-94	apolipoprotein E	Homo sapiens	39-43
34557909-2	2021	Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain.	Fatty Acids, Unsaturated	96-100	sortilin 1	Homo sapiens	0-8
34557909-2	2021	Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain.	Fatty Acids, Unsaturated	96-100	apolipoprotein E	Homo sapiens	39-43
34387861-0	2021	The SAC1 phosphatase domain of synaptojanin-1 is activated by interacting with polyunsaturated fatty acid-containing phosphatidic acids.	Fatty Acids, Unsaturated	79-105	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	4-8
34346724-3	2021	This study complements the previous study by examining the effects of fasting duration and insulin infusion on circulating levels of oxylipins, bioactive metabolites derived from the oxygenation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	198-225	insulin	Homo sapiens	91-98
34174394-1	2021	The arachidonate 12-lipoxygenase (ALOX12) enzyme catalyzes polyunsaturated fatty acids and facilitates generation of bioactive lipid mediators associated with various biological processes and disease pathologies.	Fatty Acids, Unsaturated	59-86	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	4-32
34174394-1	2021	The arachidonate 12-lipoxygenase (ALOX12) enzyme catalyzes polyunsaturated fatty acids and facilitates generation of bioactive lipid mediators associated with various biological processes and disease pathologies.	Fatty Acids, Unsaturated	59-86	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	34-40
34387861-0	2021	The SAC1 phosphatase domain of synaptojanin-1 is activated by interacting with polyunsaturated fatty acid-containing phosphatidic acids.	Fatty Acids, Unsaturated	79-105	synaptojanin 1	Homo sapiens	31-45
34227061-3	2021	SCA type 34 (SCA34) is caused by mutations in ELOVL4 (ELOngation of Very Long-chain fatty acids 4), a fatty acid elongase essential for biosynthesis of Very Long Chain Saturated and Polyunsaturated Fatty Acids (VLC-SFA and VLC-PUFA, resp., >=28 carbons), which have important functions in the brain, skin, retina, Meibomian glands, testes, and sperm.	Fatty Acids, Unsaturated	182-209	ELOVL fatty acid elongase 4	Homo sapiens	13-18
34139039-7	2021	Since Elovl5 is important in attaining normal amounts of polyunsaturated fatty acids, which are the principal component of myelin, we performed a lipidomic analysis of peripheral nerves of Elovl5-deficient mice.	Fatty Acids, Unsaturated	57-84	ELOVL family member 5, elongation of long chain fatty acids (yeast)	Mus musculus	6-12
34227061-3	2021	SCA type 34 (SCA34) is caused by mutations in ELOVL4 (ELOngation of Very Long-chain fatty acids 4), a fatty acid elongase essential for biosynthesis of Very Long Chain Saturated and Polyunsaturated Fatty Acids (VLC-SFA and VLC-PUFA, resp., >=28 carbons), which have important functions in the brain, skin, retina, Meibomian glands, testes, and sperm.	Fatty Acids, Unsaturated	182-209	ELOVL fatty acid elongase 4	Rattus norvegicus	46-52
34129179-10	2021	Our results describe a new LPCAT enzyme that can be used to biotechnologically alter oilseed crops to incorporate more PUFA in its seed oil.	Fatty Acids, Unsaturated	119-123	lysophosphatidylcholine acyltransferase	Saccharomyces cerevisiae S288C	27-32
34638573-1	2021	13-lipoxygenases (13-LOX) catalyze the dioxygenation of various polyunsaturated fatty acids (PUFAs), of which alpha-linolenic acid (LeA) is converted to 13-S-hydroperoxyoctadeca-9, 11, 15-trienoic acid (13-HPOT), the precursor for the prostaglandin-like plant hormones cis-(+)-12-oxophytodienoic acid (12-OPDA) and methyl jasmonate (MJ).	Fatty Acids, Unsaturated	64-91	lysyl oxidase	Homo sapiens	21-24
34505434-15	2021	Alterations in polyunsaturated fatty acids, such as EPA and DHA, link LAMTOR1 to inflammatory and immune processes, which are known to play important roles in NASH pathogenesis.	Fatty Acids, Unsaturated	15-42	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	Mus musculus	70-77
34638763-6	2021	However, n-3 polyunsaturated fatty acids (PUFA) were decreased in the category with the highest C-peptide concentration (n-3 PUFA: CI -35.82--6.28, p < 0.006) and in the lowest ISHOMA category (n-3 PUFA: CI -36.48--5.61, p < 0.008).	Fatty Acids, Unsaturated	42-46	insulin	Homo sapiens	96-105
34658895-1	2021	Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH.	Fatty Acids, Unsaturated	134-161	potassium two pore domain channel subfamily K member 2	Homo sapiens	37-42
34658895-1	2021	Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH.	Fatty Acids, Unsaturated	134-161	potassium two pore domain channel subfamily K member 4	Homo sapiens	43-48
34638573-1	2021	13-lipoxygenases (13-LOX) catalyze the dioxygenation of various polyunsaturated fatty acids (PUFAs), of which alpha-linolenic acid (LeA) is converted to 13-S-hydroperoxyoctadeca-9, 11, 15-trienoic acid (13-HPOT), the precursor for the prostaglandin-like plant hormones cis-(+)-12-oxophytodienoic acid (12-OPDA) and methyl jasmonate (MJ).	Fatty Acids, Unsaturated	93-98	lysyl oxidase	Homo sapiens	21-24
34543263-8	2021	Lipidomic analyses of postprandial plasma from high-fat fed Lipg-/- mice demonstrated accumulation of phospholipids and TGs harboring long-chain polyunsaturated fatty acids (PUFAs), known substrates for EL lipolysis.	Fatty Acids, Unsaturated	174-179	lipase, endothelial	Mus musculus	60-64
34684338-6	2021	In CHC subjects, polyunsaturated fatty acid intake (PUFA >= 4.9%) was negatively associated, and fiber intake (>=21.5 g/day) was positively associated with a high viral load (p < 0.036).	Fatty Acids, Unsaturated	17-43	pumilio RNA binding family member 3	Homo sapiens	52-56
34525866-0	2021	Trewioidesine A, an unsaturated fatty acid from rhizomes of Alchornea trewioides, shows synergy with NGF in inducing differentiation of pheochromocytoma PC12 cells.	Fatty Acids, Unsaturated	20-42	nerve growth factor	Rattus norvegicus	101-104
34229049-4	2021	Docosahexaenoic acid (DHA), the primary omega-3 long-chain polyunsaturated fatty acid (LC-PUFA), reduces abnormal neovascularization and alleviates neovascular eye diseases.	Fatty Acids, Unsaturated	59-85	pumilio RNA binding family member 3	Homo sapiens	90-94
34496007-7	2021	In contrast, infection of TLR2-deficient mice restored inflammatory cytokines and bacterial burden to wildtype levels, linking the shift in acyl chain composition toward UFA to detrimental immune activation in vivo.	Fatty Acids, Unsaturated	170-173	toll-like receptor 2	Mus musculus	26-30
34496007-8	2021	In in vitro studies, bacterial lipoproteins isolated from UFA-supplemented cultures were resistant to lipase-mediated ester hydrolysis and exhibited heightened TLR2-dependent innate cell activation, whereas lipoproteins with BCFA esters were completely inactivated after lipase treatment.	Fatty Acids, Unsaturated	58-61	toll-like receptor 2	Mus musculus	160-164
34499923-5	2022	Recent reports indicate that HO-1 with its antioxidants via the effect of bilirubin increases formation of biologically active lipid metabolites such as epoxyeicosatrienoic acid (EET), omega-3 and other polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	203-230	heme oxygenase 1	Homo sapiens	29-33
34499923-5	2022	Recent reports indicate that HO-1 with its antioxidants via the effect of bilirubin increases formation of biologically active lipid metabolites such as epoxyeicosatrienoic acid (EET), omega-3 and other polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	232-237	heme oxygenase 1	Homo sapiens	29-33
34486255-1	2021	Arachidonic acid 15-lipoxygenase (ALOX15) is an enzyme that can oxidize polyunsaturated fatty acids.	Fatty Acids, Unsaturated	72-99	arachidonate 15-lipoxygenase	Homo sapiens	34-40
34271000-1	2021	Mixed chain phospholipids containing a saturated fatty acid at sn1 and a polyunsaturated fatty acid in sn2 are common in the specialized biological membranes prevalent in neural, retinal and organ tissues.	Fatty Acids, Unsaturated	73-99	solute carrier family 38 member 5	Homo sapiens	103-106
34355478-2	2021	The high moisture content, high-quality protein with all essential amino acids and unsaturated fatty acids makes AFP more susceptible to microbial spoilage and oxidation of lipids and proteins.	Fatty Acids, Unsaturated	83-106	alpha fetoprotein	Homo sapiens	113-116
34474906-2	2021	12-lipoxygenase (12-LOX) is expressed in several cell types, including macrophages, and oxidizes polyunsaturated fatty acids (PUFAs) to generate both pro- and anti-inflammatory lipid mediators, of which the n-3 PUFAs play an important part in tissue homeostasis/fibrosis.	Fatty Acids, Unsaturated	97-124	arachidonate 15-lipoxygenase	Rattus norvegicus	0-15
34474906-2	2021	12-lipoxygenase (12-LOX) is expressed in several cell types, including macrophages, and oxidizes polyunsaturated fatty acids (PUFAs) to generate both pro- and anti-inflammatory lipid mediators, of which the n-3 PUFAs play an important part in tissue homeostasis/fibrosis.	Fatty Acids, Unsaturated	97-124	arachidonate 15-lipoxygenase	Rattus norvegicus	17-23
34474906-2	2021	12-lipoxygenase (12-LOX) is expressed in several cell types, including macrophages, and oxidizes polyunsaturated fatty acids (PUFAs) to generate both pro- and anti-inflammatory lipid mediators, of which the n-3 PUFAs play an important part in tissue homeostasis/fibrosis.	Fatty Acids, Unsaturated	126-131	arachidonate 15-lipoxygenase	Rattus norvegicus	0-15
34474906-2	2021	12-lipoxygenase (12-LOX) is expressed in several cell types, including macrophages, and oxidizes polyunsaturated fatty acids (PUFAs) to generate both pro- and anti-inflammatory lipid mediators, of which the n-3 PUFAs play an important part in tissue homeostasis/fibrosis.	Fatty Acids, Unsaturated	126-131	arachidonate 15-lipoxygenase	Rattus norvegicus	17-23
34516363-3	2021	Due to its composition, rich in selenium and unsaturated fatty acids, Brazil nuts have been related to reduced oxidative stress and inflammation in chronic non-communicable diseases and could regulate PPARbeta/delta.	Fatty Acids, Unsaturated	45-68	peroxisome proliferator activated receptor alpha	Homo sapiens	201-215
34520742-2	2022	Here we show that HCV is restricted by an iron-dependent mechanism resembling the one triggering ferroptosis, an iron-dependent form of non-apoptotic cell death, and mediated by the non-canonical desaturation of oleate to Mead acid and other highly unsaturated fatty acids by fatty acid desaturase 2 (FADS2).	Fatty Acids, Unsaturated	249-272	fatty acid desaturase 2	Homo sapiens	276-299
34520742-2	2022	Here we show that HCV is restricted by an iron-dependent mechanism resembling the one triggering ferroptosis, an iron-dependent form of non-apoptotic cell death, and mediated by the non-canonical desaturation of oleate to Mead acid and other highly unsaturated fatty acids by fatty acid desaturase 2 (FADS2).	Fatty Acids, Unsaturated	249-272	fatty acid desaturase 2	Homo sapiens	301-306
34247449-6	2021	Notably, the immune pathway up-regulation is probably induced by accumulated unsaturated fatty acids which are predicted to interact with multiple immune regulators like SRC and TGFB1.	Fatty Acids, Unsaturated	77-100	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	170-173
34247449-6	2021	Notably, the immune pathway up-regulation is probably induced by accumulated unsaturated fatty acids which are predicted to interact with multiple immune regulators like SRC and TGFB1.	Fatty Acids, Unsaturated	77-100	transforming growth factor beta 1	Homo sapiens	178-183
34333551-2	2021	Here, we show that ELOngation of Very Long chain fatty acids protein 4 (ELOVL4), a rate-limiting enzyme in the biosynthesis of very-long polyunsaturated fatty acids (n-3, >=28 C), is expressed and transcriptionally repressed by the oncogene MYCN in neuroblastoma cells.	Fatty Acids, Unsaturated	137-164	ELOVL fatty acid elongase 4	Homo sapiens	72-78
34333551-2	2021	Here, we show that ELOngation of Very Long chain fatty acids protein 4 (ELOVL4), a rate-limiting enzyme in the biosynthesis of very-long polyunsaturated fatty acids (n-3, >=28 C), is expressed and transcriptionally repressed by the oncogene MYCN in neuroblastoma cells.	Fatty Acids, Unsaturated	137-164	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	241-245
34514442-6	2021	In this review, the author discusses the role of sEH in the metabolism of omega-3 PUFAs in the context of depression, and the clinical value of sEH inhibitors as alternative therapeutic strategies for patients suffering from this condition.	Fatty Acids, Unsaturated	82-87	epoxide hydrolase 2	Homo sapiens	49-52
34502126-0	2021	Study on the Introduction of Solid Fat with a High Content of Unsaturated Fatty Acids to Gluten-Free Muffins as a Basis for Designing Food with Higher Health Value.	Fatty Acids, Unsaturated	62-85	FAT atypical cadherin 1	Homo sapiens	35-38
34440461-7	2021	Zebrafish Elovl8a could elongate the polyunsaturated fatty acids (PUFAs) C18:2n-6 and C18:3n-3 to C20:2n-6 and C20:3n-3, respectively.	Fatty Acids, Unsaturated	37-64	ELOVL fatty acid elongase 8a	Danio rerio	10-17
34440461-7	2021	Zebrafish Elovl8a could elongate the polyunsaturated fatty acids (PUFAs) C18:2n-6 and C18:3n-3 to C20:2n-6 and C20:3n-3, respectively.	Fatty Acids, Unsaturated	66-71	ELOVL fatty acid elongase 8a	Danio rerio	10-17
34102280-2	2021	The rationale of the COX-2 inhibitor lies in suppressing COX-2 catalyzed peroxidation of omega-6 polyunsaturated fatty acids (PUFAs), which are essential and pervasive in our daily diet.	Fatty Acids, Unsaturated	126-131	prostaglandin-endoperoxide synthase 2	Mus musculus	21-26
34102280-2	2021	The rationale of the COX-2 inhibitor lies in suppressing COX-2 catalyzed peroxidation of omega-6 polyunsaturated fatty acids (PUFAs), which are essential and pervasive in our daily diet.	Fatty Acids, Unsaturated	126-131	prostaglandin-endoperoxide synthase 2	Mus musculus	57-62
34440853-5	2021	The increased activity of enzymes related to the pentose-phosphate route and lipid anabolism and elevated polyunsaturated fatty acid levels were found in the hypothalamus of ND IRS2-/- mice.	Fatty Acids, Unsaturated	106-132	insulin receptor substrate 2	Mus musculus	177-181
34229160-1	2021	Ferroptosis is primarily triggered by a failure of the glutathione (GSH)-glutathione peroxidase 4 (GPX4) reductive system and associated overwhelming lipid peroxidation, in which enzymes regulating polyunsaturated fatty acid (PUFA) metabolism, and in particular acyl-CoA synthetase long chain family member 4 (ACSL4), are central.	Fatty Acids, Unsaturated	198-224	glutathione peroxidase 4	Mus musculus	73-97
34229160-1	2021	Ferroptosis is primarily triggered by a failure of the glutathione (GSH)-glutathione peroxidase 4 (GPX4) reductive system and associated overwhelming lipid peroxidation, in which enzymes regulating polyunsaturated fatty acid (PUFA) metabolism, and in particular acyl-CoA synthetase long chain family member 4 (ACSL4), are central.	Fatty Acids, Unsaturated	198-224	glutathione peroxidase 4	Mus musculus	99-103
34229160-1	2021	Ferroptosis is primarily triggered by a failure of the glutathione (GSH)-glutathione peroxidase 4 (GPX4) reductive system and associated overwhelming lipid peroxidation, in which enzymes regulating polyunsaturated fatty acid (PUFA) metabolism, and in particular acyl-CoA synthetase long chain family member 4 (ACSL4), are central.	Fatty Acids, Unsaturated	226-230	glutathione peroxidase 4	Mus musculus	73-97
34229160-1	2021	Ferroptosis is primarily triggered by a failure of the glutathione (GSH)-glutathione peroxidase 4 (GPX4) reductive system and associated overwhelming lipid peroxidation, in which enzymes regulating polyunsaturated fatty acid (PUFA) metabolism, and in particular acyl-CoA synthetase long chain family member 4 (ACSL4), are central.	Fatty Acids, Unsaturated	226-230	glutathione peroxidase 4	Mus musculus	99-103
34439324-1	2021	The polyunsaturated fatty acid (PUFA) elongase, ELOVL5, is upregulated in breast cancer (BC) vs. adjacent normal tissue.	Fatty Acids, Unsaturated	4-30	ELOVL fatty acid elongase 5	Homo sapiens	48-54
34439324-1	2021	The polyunsaturated fatty acid (PUFA) elongase, ELOVL5, is upregulated in breast cancer (BC) vs. adjacent normal tissue.	Fatty Acids, Unsaturated	32-36	ELOVL fatty acid elongase 5	Homo sapiens	48-54
34444824-3	2021	GBM neural stem-like cells express high levels of brain fatty acid-binding protein (FABP7), which binds to polyunsaturated fatty acids (PUFAs) omega-6 arachidonic acid (AA) and omega-3 docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	107-134	glutamic-oxaloacetic transaminase 2	Homo sapiens	56-82
34348139-4	2021	Examining mitochondrial function in brown adipose tissue, we find that TXNIP KO mice have a lower content of polyunsaturated fatty acids (PUFAs) in their membrane lipids, which affects mitochondrial integrity and electron transport chain efficiency and ultimately results in lower mitochondrial heat output.	Fatty Acids, Unsaturated	109-136	thioredoxin interacting protein	Mus musculus	71-76
34348139-4	2021	Examining mitochondrial function in brown adipose tissue, we find that TXNIP KO mice have a lower content of polyunsaturated fatty acids (PUFAs) in their membrane lipids, which affects mitochondrial integrity and electron transport chain efficiency and ultimately results in lower mitochondrial heat output.	Fatty Acids, Unsaturated	138-143	thioredoxin interacting protein	Mus musculus	71-76
34350478-3	2021	A wide range of unsaturated fatty acids can be hydrated at the C10 and in some cases the C13 position.	Fatty Acids, Unsaturated	16-39	homeobox C10	Homo sapiens	63-66
34350478-3	2021	A wide range of unsaturated fatty acids can be hydrated at the C10 and in some cases the C13 position.	Fatty Acids, Unsaturated	16-39	homeobox C13	Homo sapiens	89-92
34444824-3	2021	GBM neural stem-like cells express high levels of brain fatty acid-binding protein (FABP7), which binds to polyunsaturated fatty acids (PUFAs) omega-6 arachidonic acid (AA) and omega-3 docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	107-134	fatty acid binding protein 7	Homo sapiens	84-89
34444824-3	2021	GBM neural stem-like cells express high levels of brain fatty acid-binding protein (FABP7), which binds to polyunsaturated fatty acids (PUFAs) omega-6 arachidonic acid (AA) and omega-3 docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	136-141	glutamic-oxaloacetic transaminase 2	Homo sapiens	56-82
34444824-3	2021	GBM neural stem-like cells express high levels of brain fatty acid-binding protein (FABP7), which binds to polyunsaturated fatty acids (PUFAs) omega-6 arachidonic acid (AA) and omega-3 docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	136-141	fatty acid binding protein 7	Homo sapiens	84-89
34196621-3	2021	Structures of unsaturated fatty acids, such as oleic acid (OA) and docosahexaenoic acid (DHA), bound to FABP7 have been elucidated; however, structures of saturated fatty acids bound to FABP7 remain unknown.	Fatty Acids, Unsaturated	14-37	fatty acid binding protein 7	Homo sapiens	104-109
34167916-2	2021	Two recent studies (Zou et al., 2020; Cui et al., 2021) not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid (plasmalogen) synthesis in ferroptosis.	Fatty Acids, Unsaturated	155-181	plasmanylethanolamine desaturase 1	Homo sapiens	275-282
34227403-4	2021	LXR activation has been shown to endogenously reprogram cellular lipid profiles toward increased polyunsaturated fatty acids levels.	Fatty Acids, Unsaturated	97-124	nuclear receptor subfamily 1, group H, member 3	Mus musculus	0-3
34227403-11	2021	Conclusions The present study provides evidence that the LXR agonist AZ876 prevents subendocardial damage, improves global longitudinal strain and E/e" in a mouse model of isoproterenol-induced cardiac damage, accompanied by an upregulation of cardiac polyunsaturated fatty acids levels.	Fatty Acids, Unsaturated	252-279	nuclear receptor subfamily 1, group H, member 3	Mus musculus	57-60
34394165-7	2021	The FAD2, LOC10515945, LOC105161564, and LOC105162196 genes were clustered into groups that regulate the accumulation of unsaturated fatty acid (UFA) biosynthesis.	Fatty Acids, Unsaturated	121-143	omega-6 fatty acid desaturase, endoplasmic reticulum isozyme 2	Sesamum indicum	4-8
34394165-7	2021	The FAD2, LOC10515945, LOC105161564, and LOC105162196 genes were clustered into groups that regulate the accumulation of unsaturated fatty acid (UFA) biosynthesis.	Fatty Acids, Unsaturated	145-148	omega-6 fatty acid desaturase, endoplasmic reticulum isozyme 2	Sesamum indicum	4-8
34196621-3	2021	Structures of unsaturated fatty acids, such as oleic acid (OA) and docosahexaenoic acid (DHA), bound to FABP7 have been elucidated; however, structures of saturated fatty acids bound to FABP7 remain unknown.	Fatty Acids, Unsaturated	14-37	fatty acid binding protein 7	Homo sapiens	186-191
34143495-5	2021	Hepatic gene expression of key enzymes of desaturation (Fads1/Fads2) of n-6 and n-3 polyunsaturated fatty acids (PUFAs), of phosphatidylethanolamine (PE) N-methyltransferase (Pemt), of fatty acid translocase Cd36, and of glucose-6-phosphate isomerase (Gpi) were quantified by Real Time-PCR.	Fatty Acids, Unsaturated	113-118	fatty acid desaturase 1	Homo sapiens	56-61
34090092-8	2021	In addition, KEGG enrichment analysis showed that there were not only pathways which were directly related to metabolisms such as protein digestion and absorption pathway, fatty acid metabolism pathway, and biosynthesis pathway of unsaturated fatty acids, but also PI3K-AKT pathway, AMPK pathway, MAPK pathway, and FoxO pathway which were important to metabolism among the top 20 pathways with the lowest significant Q value.	Fatty Acids, Unsaturated	231-254	RAC-alpha serine/threonine-protein kinase	Ovis aries	270-273
34143495-5	2021	Hepatic gene expression of key enzymes of desaturation (Fads1/Fads2) of n-6 and n-3 polyunsaturated fatty acids (PUFAs), of phosphatidylethanolamine (PE) N-methyltransferase (Pemt), of fatty acid translocase Cd36, and of glucose-6-phosphate isomerase (Gpi) were quantified by Real Time-PCR.	Fatty Acids, Unsaturated	113-118	fatty acid desaturase 2	Homo sapiens	62-67
34092035-3	2021	Polyunsaturated fatty acid-containing phospholipids are the main substrates of lipid peroxidation in ferroptosis, which is positively regulated by enzymes, such as ACSL4, LPCAT3, ALOXs, or POR.	Fatty Acids, Unsaturated	0-26	acyl-CoA synthetase long chain family member 4	Homo sapiens	164-169
34155967-0	2021	Caveolin-1 Genetic Polymorphism Interact with Polyunsaturated Fatty Acids to Modulate Metabolic Syndrome Risk.	Fatty Acids, Unsaturated	46-73	caveolin 1	Homo sapiens	0-10
34199164-3	2021	Previous studies have demonstrated the overexpression of enzymes associated with lipid metabolism, including stearoyl-CoA desaturase-1 (SCD-1), which increases the concentration of unsaturated fatty acids in tumor cells.	Fatty Acids, Unsaturated	181-204	stearoyl-CoA desaturase	Homo sapiens	109-134
34199164-3	2021	Previous studies have demonstrated the overexpression of enzymes associated with lipid metabolism, including stearoyl-CoA desaturase-1 (SCD-1), which increases the concentration of unsaturated fatty acids in tumor cells.	Fatty Acids, Unsaturated	181-204	stearoyl-CoA desaturase	Homo sapiens	136-141
34207160-3	2021	Thus, the modification of the FA profile-especially an increase in the concentration of polyunsaturated FAs and n-3 FAs in bovine milk fat-is desirable.	Fatty Acids, Unsaturated	88-107	FAT atypical cadherin 1	Bos taurus	135-138
34208689-11	2021	The metabolic cascade of polyunsaturated fatty acids (n3 PUFA) and the synthesis of (AA) can be involved in pathogenesis of stroke-related cognitive impairment.	Fatty Acids, Unsaturated	25-52	pumilio RNA binding family member 3	Homo sapiens	57-61
34092035-3	2021	Polyunsaturated fatty acid-containing phospholipids are the main substrates of lipid peroxidation in ferroptosis, which is positively regulated by enzymes, such as ACSL4, LPCAT3, ALOXs, or POR.	Fatty Acids, Unsaturated	0-26	cytochrome p450 oxidoreductase	Homo sapiens	189-192
34092035-3	2021	Polyunsaturated fatty acid-containing phospholipids are the main substrates of lipid peroxidation in ferroptosis, which is positively regulated by enzymes, such as ACSL4, LPCAT3, ALOXs, or POR.	Fatty Acids, Unsaturated	0-26	lysophosphatidylcholine acyltransferase 3	Homo sapiens	171-177
34370287-3	2021	Given this role of ferritinophagy in regulating iron homeostasis, modulating NCOA4-mediated ferritinophagic flux alters sensitivity to ferroptosis, a non-apoptotic iron-dependent form of cell death triggered by peroxidation of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	227-254	nuclear receptor coactivator 4	Homo sapiens	77-82
34072555-7	2021	DGAT1 genotype influenced the fatty acid composition: milk from AA cows had a more favorable fatty acid composition due to lower total saturated fatty acids, saturated to unsaturated ratio, atherogenic index, and higher levels of oleic acid and total unsaturated fatty acids.	Fatty Acids, Unsaturated	251-274	diacylglycerol O-acyltransferase 1	Bos taurus	0-5
33960023-3	2021	Hallmarks of ferroptosis, including peroxidation of polyunsaturated fatty acids, are conserved among animals and plants, however, early divergence of an ancestral mammalian GPX4 (mGPX4) has complicated our understanding of mechanistic similarities between species.	Fatty Acids, Unsaturated	52-79	glutathione peroxidase 4	Homo sapiens	173-177
34176006-1	2021	Long-chain (>= C20) polyunsaturated fatty acids (LC-PUFA), such as eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA), are necessary for human health and are obtained from marine fish-derived oils.	Fatty Acids, Unsaturated	20-47	pumilio RNA binding family member 3	Homo sapiens	52-56
34370287-3	2021	Given this role of ferritinophagy in regulating iron homeostasis, modulating NCOA4-mediated ferritinophagic flux alters sensitivity to ferroptosis, a non-apoptotic iron-dependent form of cell death triggered by peroxidation of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	256-261	nuclear receptor coactivator 4	Homo sapiens	77-82
34825869-1	2021	The N-3 polyunsaturated fatty acids (PUFAs) have a wide range of health benefits, including anti-inflammatory effects, improvements in lipids metabolism and promoting insulin secretion, as well as reduction of cancer risk.	Fatty Acids, Unsaturated	37-42	insulin	Homo sapiens	167-174
34474084-3	2021	Among the PLA2 superfamily, the cytosolic cPLA2 enzymes, calcium-independent iPLA2 enzymes, and secreted sPLA2 enzymes are implicated in many diseases, but a central issue is the preference for double-bond positions in polyunsaturated fatty acids (PUFAs) occupying the sn-2 position of membrane phospholipids.	Fatty Acids, Unsaturated	219-246	phospholipase A2 group VI	Homo sapiens	10-14
34105707-1	2021	Polyunsaturated fatty acids help maintain insulin sensitivity, mitochondrial function, and anti-inflammation.	Fatty Acids, Unsaturated	0-27	insulin	Homo sapiens	42-49
34585216-4	2021	DESIGN: The Multidomain Alzheimer Preventive Trial (MAPT) study was a multicenter, randomized, placebo-controlled superiority trial with four parallel groups, including three intervention groups (one group with Multidomain Intervention (MI) plus a placebo, one group with Polyunsaturated Fatty Acids (PFA), one group with a combination of PFA and MI) and one placebo group.	Fatty Acids, Unsaturated	301-304	microtubule associated protein tau	Homo sapiens	52-56
34585216-7	2021	INTERVENTIONS: We used data from the MAPT study which aims to test the efficacy of a MI along PFA, the MI plus a placebo, PFA alone, or a placebo alone.	Fatty Acids, Unsaturated	94-97	microtubule associated protein tau	Homo sapiens	37-41
35417841-7	2022	This work provided theoretical basis for the development of nutritional supplements containing unsaturated fatty acids encapsulated by beta-CD.	Fatty Acids, Unsaturated	95-118	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	135-142
34478876-4	2021	Interestingly, downregulation of MALAT1 reduced the abundances of multiple genes in the AMP-activated protein kinase (AMPK) signaling and biosynthesis of unsaturated fatty acids pathways.	Fatty Acids, Unsaturated	154-177	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	33-39
34474084-3	2021	Among the PLA2 superfamily, the cytosolic cPLA2 enzymes, calcium-independent iPLA2 enzymes, and secreted sPLA2 enzymes are implicated in many diseases, but a central issue is the preference for double-bond positions in polyunsaturated fatty acids (PUFAs) occupying the sn-2 position of membrane phospholipids.	Fatty Acids, Unsaturated	219-246	phospholipase A2 group IVA	Homo sapiens	42-47
34474084-3	2021	Among the PLA2 superfamily, the cytosolic cPLA2 enzymes, calcium-independent iPLA2 enzymes, and secreted sPLA2 enzymes are implicated in many diseases, but a central issue is the preference for double-bond positions in polyunsaturated fatty acids (PUFAs) occupying the sn-2 position of membrane phospholipids.	Fatty Acids, Unsaturated	219-246	phospholipase A2 group VI	Homo sapiens	77-82
34474084-3	2021	Among the PLA2 superfamily, the cytosolic cPLA2 enzymes, calcium-independent iPLA2 enzymes, and secreted sPLA2 enzymes are implicated in many diseases, but a central issue is the preference for double-bond positions in polyunsaturated fatty acids (PUFAs) occupying the sn-2 position of membrane phospholipids.	Fatty Acids, Unsaturated	219-246	phospholipase A2 group IIA	Homo sapiens	105-110
34474084-3	2021	Among the PLA2 superfamily, the cytosolic cPLA2 enzymes, calcium-independent iPLA2 enzymes, and secreted sPLA2 enzymes are implicated in many diseases, but a central issue is the preference for double-bond positions in polyunsaturated fatty acids (PUFAs) occupying the sn-2 position of membrane phospholipids.	Fatty Acids, Unsaturated	248-253	phospholipase A2 group VI	Homo sapiens	10-14
34474084-3	2021	Among the PLA2 superfamily, the cytosolic cPLA2 enzymes, calcium-independent iPLA2 enzymes, and secreted sPLA2 enzymes are implicated in many diseases, but a central issue is the preference for double-bond positions in polyunsaturated fatty acids (PUFAs) occupying the sn-2 position of membrane phospholipids.	Fatty Acids, Unsaturated	248-253	phospholipase A2 group IVA	Homo sapiens	42-47
34474084-3	2021	Among the PLA2 superfamily, the cytosolic cPLA2 enzymes, calcium-independent iPLA2 enzymes, and secreted sPLA2 enzymes are implicated in many diseases, but a central issue is the preference for double-bond positions in polyunsaturated fatty acids (PUFAs) occupying the sn-2 position of membrane phospholipids.	Fatty Acids, Unsaturated	248-253	phospholipase A2 group VI	Homo sapiens	77-82
34474084-3	2021	Among the PLA2 superfamily, the cytosolic cPLA2 enzymes, calcium-independent iPLA2 enzymes, and secreted sPLA2 enzymes are implicated in many diseases, but a central issue is the preference for double-bond positions in polyunsaturated fatty acids (PUFAs) occupying the sn-2 position of membrane phospholipids.	Fatty Acids, Unsaturated	248-253	phospholipase A2 group IIA	Homo sapiens	105-110
35473971-4	2022	Following exposure to salt stress, Lactiplantibacillus plantarum LIP-1 cells exuded excessive Na+ out of the cell and transported extracellular K+ into the cell, resulting in upregulation of the trkA gene, which is related to K+ transport, thereby significantly upregulating the expression of a lysR-type transcription factor, which increased the cell membrane unsaturated fatty acid content, reducing the degree of cell membrane damage and improving the freeze-drying survival rate.	Fatty Acids, Unsaturated	361-383	PTPRF interacting protein alpha 1	Homo sapiens	65-70
35473971-4	2022	Following exposure to salt stress, Lactiplantibacillus plantarum LIP-1 cells exuded excessive Na+ out of the cell and transported extracellular K+ into the cell, resulting in upregulation of the trkA gene, which is related to K+ transport, thereby significantly upregulating the expression of a lysR-type transcription factor, which increased the cell membrane unsaturated fatty acid content, reducing the degree of cell membrane damage and improving the freeze-drying survival rate.	Fatty Acids, Unsaturated	361-383	neurotrophic receptor tyrosine kinase 1	Homo sapiens	195-199
35551368-3	2022	Patients and Gimap6-/- mice show defects in autophagy, redox regulation, and polyunsaturated fatty acid (PUFA)-containing lipids.	Fatty Acids, Unsaturated	77-103	GTPase, IMAP family member 6	Homo sapiens	13-19
35367352-1	2022	Oxylipins are oxygenated derivatives of polyunsaturated fatty acids, generated by COX, LOX and CYP enzymes, that regulate various aspects of endothelial cell physiology.	Fatty Acids, Unsaturated	40-67	cytochrome c oxidase subunit 8A	Homo sapiens	82-85
35367352-1	2022	Oxylipins are oxygenated derivatives of polyunsaturated fatty acids, generated by COX, LOX and CYP enzymes, that regulate various aspects of endothelial cell physiology.	Fatty Acids, Unsaturated	40-67	lysyl oxidase	Homo sapiens	87-90
35489698-1	2022	The risk of chronic hepatitis B (CHB) infection is often affected by polyunsaturated fatty acids (PUFAs) metabolism which is strongly influenced by single nucleotide polymorphisms (SNPs) within the PUFA metabolic pathway.	Fatty Acids, Unsaturated	69-96	pumilio RNA binding family member 3	Homo sapiens	198-202
35489698-1	2022	The risk of chronic hepatitis B (CHB) infection is often affected by polyunsaturated fatty acids (PUFAs) metabolism which is strongly influenced by single nucleotide polymorphisms (SNPs) within the PUFA metabolic pathway.	Fatty Acids, Unsaturated	98-103	pumilio RNA binding family member 3	Homo sapiens	198-202
35238901-9	2022	The decreased oocyte LD content is likely related to an altered serum lipidome, with Gclm-/- serum having relatively lower unsaturated fatty acids and triglycerides than that of Gclm+/+ and Gclm+/- females.	Fatty Acids, Unsaturated	123-146	glutamate-cysteine ligase modifier subunit	Homo sapiens	85-89
35577309-3	2022	15-lipoxygenase accounts as a key enzyme in metabolizing polyunsaturated fatty acids that generate various inflammatory lipid metabolites.	Fatty Acids, Unsaturated	57-84	arachidonate 15-lipoxygenase	Homo sapiens	0-15
35551368-3	2022	Patients and Gimap6-/- mice show defects in autophagy, redox regulation, and polyunsaturated fatty acid (PUFA)-containing lipids.	Fatty Acids, Unsaturated	105-109	GTPase, IMAP family member 6	Homo sapiens	13-19
35292995-1	2022	As a member of the fatty acid desaturase family, fatty acid desaturase 2 (FADS2) gene is a rate-limiting enzyme in the synthesis of unsaturated fatty acids and within/near to the reported QTL regions for milk-production traits.	Fatty Acids, Unsaturated	132-155	fatty acid desaturase 2	Bos taurus	49-72
35292995-1	2022	As a member of the fatty acid desaturase family, fatty acid desaturase 2 (FADS2) gene is a rate-limiting enzyme in the synthesis of unsaturated fatty acids and within/near to the reported QTL regions for milk-production traits.	Fatty Acids, Unsaturated	132-155	fatty acid desaturase 2	Bos taurus	74-79
35283177-6	2022	Importantly, Piezo1 function is regulated via force-from-lipids through the lipid composition of the membrane and membranous incorporation of polyunsaturated fatty acids (PUFAs) can affect the function of Piezo1 altering mechanosensitive properties of the cell.	Fatty Acids, Unsaturated	142-169	piezo type mechanosensitive ion channel component 1	Homo sapiens	13-19
35411365-7	2022	Otherwise, our data suggested significant positive relationships between polyunsaturated fatty acids (ARA, EPA, ALA) and nhr-80, fat-5, fat-6 and fat-7.	Fatty Acids, Unsaturated	73-100	Nuclear Hormone Receptor family	Caenorhabditis elegans	121-127
35411365-7	2022	Otherwise, our data suggested significant positive relationships between polyunsaturated fatty acids (ARA, EPA, ALA) and nhr-80, fat-5, fat-6 and fat-7.	Fatty Acids, Unsaturated	73-100	Delta(9)-fatty-acid desaturase fat-7	Caenorhabditis elegans	146-151
35548952-1	2022	Delta-5 desaturase (D5D), encoded by the fatty acid desaturase 1 (FADS1) gene, is a rate-limiting enzyme in polyunsaturated fatty acid (PUFA) synthesis that influences the PUFA levels in milk fat.	Fatty Acids, Unsaturated	136-140	fatty acid desaturase 1	Homo sapiens	41-64
35548952-1	2022	Delta-5 desaturase (D5D), encoded by the fatty acid desaturase 1 (FADS1) gene, is a rate-limiting enzyme in polyunsaturated fatty acid (PUFA) synthesis that influences the PUFA levels in milk fat.	Fatty Acids, Unsaturated	136-140	fatty acid desaturase 1	Homo sapiens	66-71
35605262-8	2022	We proposed 12 genomic regions under selection pressure involving CNVs which were previously reported to be associated with metabolism energy (SLC5A8), champagne dilution in horses (SLC36A1), and synthesis of polyunsaturated fatty acids (FAT2).	Fatty Acids, Unsaturated	209-236	FAT atypical cadherin 2	Equus caballus	238-242
35631303-0	2022	Investigation of Maternal Diet and FADS1 Polymorphism Associated with Long-Chain Polyunsaturated Fatty Acid Compositions in Human Milk.	Fatty Acids, Unsaturated	81-107	fatty acid desaturase 1	Homo sapiens	35-40
35605891-7	2022	These findings provided direct evidence that SNEs containing PUFAs can upregulate insulin-pAKT pathway, facilitate insulin trafficking at the BBB, and thereby address cerebrovascular dysfunction in metabolic and neurodegenerative diseases.	Fatty Acids, Unsaturated	61-66	insulin	Homo sapiens	82-89
35605891-7	2022	These findings provided direct evidence that SNEs containing PUFAs can upregulate insulin-pAKT pathway, facilitate insulin trafficking at the BBB, and thereby address cerebrovascular dysfunction in metabolic and neurodegenerative diseases.	Fatty Acids, Unsaturated	61-66	insulin	Homo sapiens	115-122
35597366-11	2022	Interestingly, the interactions of adenosine receptors (A2AAR, A1AR) with CYP450-epoxygenases, omega-hydroxylases, sEH, and their derived metabolites or oxygenated polyunsaturated fatty acids (PUFAs or oxylipins) is shown in the regulation of the cardiovascular functions.	Fatty Acids, Unsaturated	164-191	adenosine A2a receptor	Mus musculus	56-61
35597366-11	2022	Interestingly, the interactions of adenosine receptors (A2AAR, A1AR) with CYP450-epoxygenases, omega-hydroxylases, sEH, and their derived metabolites or oxygenated polyunsaturated fatty acids (PUFAs or oxylipins) is shown in the regulation of the cardiovascular functions.	Fatty Acids, Unsaturated	164-191	adenosine A1 receptor	Mus musculus	63-67
35597366-11	2022	Interestingly, the interactions of adenosine receptors (A2AAR, A1AR) with CYP450-epoxygenases, omega-hydroxylases, sEH, and their derived metabolites or oxygenated polyunsaturated fatty acids (PUFAs or oxylipins) is shown in the regulation of the cardiovascular functions.	Fatty Acids, Unsaturated	164-191	epoxide hydrolase 2, cytoplasmic	Mus musculus	115-118
35597366-11	2022	Interestingly, the interactions of adenosine receptors (A2AAR, A1AR) with CYP450-epoxygenases, omega-hydroxylases, sEH, and their derived metabolites or oxygenated polyunsaturated fatty acids (PUFAs or oxylipins) is shown in the regulation of the cardiovascular functions.	Fatty Acids, Unsaturated	193-198	adenosine A2a receptor	Mus musculus	56-61
35597366-11	2022	Interestingly, the interactions of adenosine receptors (A2AAR, A1AR) with CYP450-epoxygenases, omega-hydroxylases, sEH, and their derived metabolites or oxygenated polyunsaturated fatty acids (PUFAs or oxylipins) is shown in the regulation of the cardiovascular functions.	Fatty Acids, Unsaturated	193-198	adenosine A1 receptor	Mus musculus	63-67
35597366-11	2022	Interestingly, the interactions of adenosine receptors (A2AAR, A1AR) with CYP450-epoxygenases, omega-hydroxylases, sEH, and their derived metabolites or oxygenated polyunsaturated fatty acids (PUFAs or oxylipins) is shown in the regulation of the cardiovascular functions.	Fatty Acids, Unsaturated	193-198	epoxide hydrolase 2, cytoplasmic	Mus musculus	115-118
35165232-2	2022	LPCAT3, a major LPLAT isoform, exhibits a strong specificity for polyunsaturated FAs s (PUFAs).	Fatty Acids, Unsaturated	65-86	lysophosphatidylcholine acyltransferase 3	Homo sapiens	0-6
35165232-2	2022	LPCAT3, a major LPLAT isoform, exhibits a strong specificity for polyunsaturated FAs s (PUFAs).	Fatty Acids, Unsaturated	65-86	membrane bound O-acyltransferase domain containing 1	Homo sapiens	16-21
35165232-2	2022	LPCAT3, a major LPLAT isoform, exhibits a strong specificity for polyunsaturated FAs s (PUFAs).	Fatty Acids, Unsaturated	88-93	lysophosphatidylcholine acyltransferase 3	Homo sapiens	0-6
35165232-2	2022	LPCAT3, a major LPLAT isoform, exhibits a strong specificity for polyunsaturated FAs s (PUFAs).	Fatty Acids, Unsaturated	88-93	membrane bound O-acyltransferase domain containing 1	Homo sapiens	16-21
35543349-7	2022	Furthermore, liver metabolomics based on UPLC-QTOF/MS demonstrated that oral administration of GAA had a significant regulatory effect on the composition of liver metabolites in mice exposed to alcohol intake, especially the levels of the biomarkers involved in the metabolic pathways of riboflavin metabolism, glycine, serine and threonine metabolism, pyruvate metabolism, glycolysis/gluconeogenesis, biosynthesis of unsaturated fatty acids, synthesis and degradation of ketone bodies, fructose and mannose metabolism.	Fatty Acids, Unsaturated	418-441	glucosidase, alpha, acid	Mus musculus	95-98
35548952-1	2022	Delta-5 desaturase (D5D), encoded by the fatty acid desaturase 1 (FADS1) gene, is a rate-limiting enzyme in polyunsaturated fatty acid (PUFA) synthesis that influences the PUFA levels in milk fat.	Fatty Acids, Unsaturated	108-134	fatty acid desaturase 1	Homo sapiens	0-18
35548952-1	2022	Delta-5 desaturase (D5D), encoded by the fatty acid desaturase 1 (FADS1) gene, is a rate-limiting enzyme in polyunsaturated fatty acid (PUFA) synthesis that influences the PUFA levels in milk fat.	Fatty Acids, Unsaturated	108-134	fatty acid desaturase 1	Homo sapiens	20-23
35548952-1	2022	Delta-5 desaturase (D5D), encoded by the fatty acid desaturase 1 (FADS1) gene, is a rate-limiting enzyme in polyunsaturated fatty acid (PUFA) synthesis that influences the PUFA levels in milk fat.	Fatty Acids, Unsaturated	108-134	fatty acid desaturase 1	Homo sapiens	41-64
35548952-1	2022	Delta-5 desaturase (D5D), encoded by the fatty acid desaturase 1 (FADS1) gene, is a rate-limiting enzyme in polyunsaturated fatty acid (PUFA) synthesis that influences the PUFA levels in milk fat.	Fatty Acids, Unsaturated	108-134	fatty acid desaturase 1	Homo sapiens	66-71
35548952-1	2022	Delta-5 desaturase (D5D), encoded by the fatty acid desaturase 1 (FADS1) gene, is a rate-limiting enzyme in polyunsaturated fatty acid (PUFA) synthesis that influences the PUFA levels in milk fat.	Fatty Acids, Unsaturated	136-140	fatty acid desaturase 1	Homo sapiens	0-18
35548952-1	2022	Delta-5 desaturase (D5D), encoded by the fatty acid desaturase 1 (FADS1) gene, is a rate-limiting enzyme in polyunsaturated fatty acid (PUFA) synthesis that influences the PUFA levels in milk fat.	Fatty Acids, Unsaturated	136-140	fatty acid desaturase 1	Homo sapiens	20-23
35605891-5	2022	Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers.	Fatty Acids, Unsaturated	79-106	AKT serine/threonine kinase 1	Homo sapiens	132-135
35605891-5	2022	Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers.	Fatty Acids, Unsaturated	79-106	AKT serine/threonine kinase 1	Homo sapiens	139-142
35605891-5	2022	Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers.	Fatty Acids, Unsaturated	79-106	insulin	Homo sapiens	209-216
35605891-5	2022	Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers.	Fatty Acids, Unsaturated	79-106	insulin	Homo sapiens	232-239
35605891-5	2022	Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers.	Fatty Acids, Unsaturated	108-113	AKT serine/threonine kinase 1	Homo sapiens	132-135
35605891-5	2022	Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers.	Fatty Acids, Unsaturated	108-113	AKT serine/threonine kinase 1	Homo sapiens	139-142
35605891-5	2022	Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers.	Fatty Acids, Unsaturated	108-113	insulin	Homo sapiens	209-216
35605891-5	2022	Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers.	Fatty Acids, Unsaturated	108-113	insulin	Homo sapiens	232-239
35283177-6	2022	Importantly, Piezo1 function is regulated via force-from-lipids through the lipid composition of the membrane and membranous incorporation of polyunsaturated fatty acids (PUFAs) can affect the function of Piezo1 altering mechanosensitive properties of the cell.	Fatty Acids, Unsaturated	142-169	piezo type mechanosensitive ion channel component 1	Homo sapiens	205-211
35283177-6	2022	Importantly, Piezo1 function is regulated via force-from-lipids through the lipid composition of the membrane and membranous incorporation of polyunsaturated fatty acids (PUFAs) can affect the function of Piezo1 altering mechanosensitive properties of the cell.	Fatty Acids, Unsaturated	171-176	piezo type mechanosensitive ion channel component 1	Homo sapiens	13-19
35283177-6	2022	Importantly, Piezo1 function is regulated via force-from-lipids through the lipid composition of the membrane and membranous incorporation of polyunsaturated fatty acids (PUFAs) can affect the function of Piezo1 altering mechanosensitive properties of the cell.	Fatty Acids, Unsaturated	171-176	piezo type mechanosensitive ion channel component 1	Homo sapiens	205-211
35321995-1	2022	Polyunsaturated fatty acids, including arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), are converted to hundreds of lipid mediators by cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 (CYP), or through non-enzymatic processes, and they reflect inflammatory states of the body.	Fatty Acids, Unsaturated	0-27	Cytochrome P450 1A1	Canis lupus familiaris	219-234
35571243-7	2022	Diets rich in n-3 polyunsaturated fatty acids (PUFAs) attenuated OA and inhibited the TLR4/NF-kappaB and NLRP3/caspase-1/GSDMD signaling pathways, whereas diets rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or n-6 PUFAs increased OA severity and activated these pathways.	Fatty Acids, Unsaturated	47-52	toll-like receptor 4	Mus musculus	86-90
35571243-7	2022	Diets rich in n-3 polyunsaturated fatty acids (PUFAs) attenuated OA and inhibited the TLR4/NF-kappaB and NLRP3/caspase-1/GSDMD signaling pathways, whereas diets rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or n-6 PUFAs increased OA severity and activated these pathways.	Fatty Acids, Unsaturated	47-52	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	91-100
35571243-7	2022	Diets rich in n-3 polyunsaturated fatty acids (PUFAs) attenuated OA and inhibited the TLR4/NF-kappaB and NLRP3/caspase-1/GSDMD signaling pathways, whereas diets rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or n-6 PUFAs increased OA severity and activated these pathways.	Fatty Acids, Unsaturated	47-52	NLR family, pyrin domain containing 3	Mus musculus	105-110
35571243-7	2022	Diets rich in n-3 polyunsaturated fatty acids (PUFAs) attenuated OA and inhibited the TLR4/NF-kappaB and NLRP3/caspase-1/GSDMD signaling pathways, whereas diets rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or n-6 PUFAs increased OA severity and activated these pathways.	Fatty Acids, Unsaturated	47-52	caspase 1	Mus musculus	111-120
35571243-7	2022	Diets rich in n-3 polyunsaturated fatty acids (PUFAs) attenuated OA and inhibited the TLR4/NF-kappaB and NLRP3/caspase-1/GSDMD signaling pathways, whereas diets rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or n-6 PUFAs increased OA severity and activated these pathways.	Fatty Acids, Unsaturated	47-52	gasdermin D	Mus musculus	121-126
35321995-1	2022	Polyunsaturated fatty acids, including arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), are converted to hundreds of lipid mediators by cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 (CYP), or through non-enzymatic processes, and they reflect inflammatory states of the body.	Fatty Acids, Unsaturated	0-27	Cytochrome P450 1A1	Canis lupus familiaris	236-239
35476941-1	2022	Three new very long chain polyunsaturated fatty acids (VLC PUFA) belonging to the omega-3 family have been identified in meibum samples collected by Schirmer strips.	Fatty Acids, Unsaturated	26-53	pumilio RNA binding family member 3	Homo sapiens	59-63
35467977-0	2022	FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	54-81	Fas-associated factor 1	Mus musculus	0-4
35467977-1	2022	SignificanceThe current study reveals the functions of FAF1 in protecting cells from ferroptosis, a novel cell death pathway triggered by PUFA peroxidation.	Fatty Acids, Unsaturated	138-142	Fas-associated factor 1	Mus musculus	55-59
35290903-10	2022	Besides, PCBP1 knockdown promoted polyunsaturated fatty acid peroxidation by increasing ALOX15 expression.	Fatty Acids, Unsaturated	34-60	poly(rC) binding protein 1	Mus musculus	9-14
35290903-10	2022	Besides, PCBP1 knockdown promoted polyunsaturated fatty acid peroxidation by increasing ALOX15 expression.	Fatty Acids, Unsaturated	34-60	arachidonate 15-lipoxygenase	Mus musculus	88-94
35563342-1	2022	It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders.	Fatty Acids, Unsaturated	103-130	epoxide hydrolase 2, cytoplasmic	Mus musculus	23-48
35563342-1	2022	It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders.	Fatty Acids, Unsaturated	103-130	epoxide hydrolase 2, cytoplasmic	Mus musculus	50-53
35563342-1	2022	It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders.	Fatty Acids, Unsaturated	103-130	epoxide hydrolase 2, cytoplasmic	Mus musculus	70-75
35563342-1	2022	It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders.	Fatty Acids, Unsaturated	132-137	epoxide hydrolase 2, cytoplasmic	Mus musculus	23-48
35563342-1	2022	It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders.	Fatty Acids, Unsaturated	132-137	epoxide hydrolase 2, cytoplasmic	Mus musculus	50-53
35563342-1	2022	It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders.	Fatty Acids, Unsaturated	132-137	epoxide hydrolase 2, cytoplasmic	Mus musculus	70-75
35564009-0	2022	Myostatin Alteration in Pigs Enhances the Deposition of Long-Chain Unsaturated Fatty Acids in Subcutaneous Fat.	Fatty Acids, Unsaturated	67-90	myostatin	Sus scrofa	0-9
35457027-9	2022	Compositional analysis of seed oil revealed that all fatty acids except 22:0 were significantly increased in the mature seeds of JcFATA-transgenic Arabidopsis lines, especially unsaturated fatty acids, such as the predominant fatty acids of seed oil, 18:1, 18:2, and 18:3.	Fatty Acids, Unsaturated	177-200	oleoyl-acyl carrier protein thioesterase 1, chloroplastic	Jatropha curcas	129-135
35565240-6	2022	We also report that BRAF V600E mutation promoted accumulation of long chain polyunsaturated fatty acids (PUFAs) and rewired metabolic flux for non-Warburg behavior.	Fatty Acids, Unsaturated	76-103	Braf transforming gene	Mus musculus	20-24
35565240-6	2022	We also report that BRAF V600E mutation promoted accumulation of long chain polyunsaturated fatty acids (PUFAs) and rewired metabolic flux for non-Warburg behavior.	Fatty Acids, Unsaturated	105-110	Braf transforming gene	Mus musculus	20-24
35120941-0	2022	Environmental adaptation in fish induced changes in the regulatory region of fatty acid elongase gene, elovl5, involved in long-chain polyunsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	134-160	elongation of very long chain fatty acids protein 5	Larimichthys crocea	103-109
35468731-8	2022	A10-FMT improved T1D-disturbed gut microbiota, especially the increase in small intestinal lactobacillus, and blood and testicular metabolome to produce n-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) to ameliorate spermatogenesis and semen quality.	Fatty Acids, Unsaturated	185-189	UDP glucuronosyltransferase 1 family, polypeptide A7C	Mus musculus	0-3
35547771-9	2022	Lipidomic analysis revealed that the elevation of unsaturated fatty acids (UFAs) was positively associated with SCD1/FADS2 levels and the oncogenic capacities of OvCa cells.	Fatty Acids, Unsaturated	50-73	stearoyl-Coenzyme A desaturase 1	Mus musculus	112-116
35547771-9	2022	Lipidomic analysis revealed that the elevation of unsaturated fatty acids (UFAs) was positively associated with SCD1/FADS2 levels and the oncogenic capacities of OvCa cells.	Fatty Acids, Unsaturated	50-73	fatty acid desaturase 2	Mus musculus	117-122
35547771-9	2022	Lipidomic analysis revealed that the elevation of unsaturated fatty acids (UFAs) was positively associated with SCD1/FADS2 levels and the oncogenic capacities of OvCa cells.	Fatty Acids, Unsaturated	75-79	stearoyl-Coenzyme A desaturase 1	Mus musculus	112-116
35547771-9	2022	Lipidomic analysis revealed that the elevation of unsaturated fatty acids (UFAs) was positively associated with SCD1/FADS2 levels and the oncogenic capacities of OvCa cells.	Fatty Acids, Unsaturated	75-79	fatty acid desaturase 2	Mus musculus	117-122
35460727-7	2022	Eosinophilic CRSwNP had profoundly enhanced unsaturated fatty acid oxidization, which correlated with mucosal eosinophil numbers and IL-5 mRNA levels.	Fatty Acids, Unsaturated	44-66	interleukin 5	Homo sapiens	133-137
35531577-3	2022	However, evidence linking UFA and WM microstructure in CHR is quite sparse.	Fatty Acids, Unsaturated	26-29	chromate resistance; sulfate transport	Homo sapiens	55-58
35531577-4	2022	Aims: We investigated the relationship between the plasma UFA level and WM microstructure in CHR participants and healthy controls (HC).	Fatty Acids, Unsaturated	58-61	chromate resistance; sulfate transport	Homo sapiens	93-96
35531577-10	2022	Conclusions: Compared with the HC group, CHR subjects exhibited a different pattern of association between WM microstructure and plasma UFA, with a neuroprotective effect found in the HC group but not in the CHR group.	Fatty Acids, Unsaturated	136-139	chromate resistance; sulfate transport	Homo sapiens	41-44
35531577-10	2022	Conclusions: Compared with the HC group, CHR subjects exhibited a different pattern of association between WM microstructure and plasma UFA, with a neuroprotective effect found in the HC group but not in the CHR group.	Fatty Acids, Unsaturated	136-139	chromate resistance; sulfate transport	Homo sapiens	208-211
35531577-11	2022	Such discrepancy could be due to the excessively upregulated UFAs accumulated in the plasma of the CHR group, highlighting the role of balanced plasma-membrane fatty acids homeostasis in WM development.	Fatty Acids, Unsaturated	61-65	chromate resistance; sulfate transport	Homo sapiens	99-102
35173101-6	2022	Conversely, unsaturated fatty acids decreased with stress treatment, which appeared to be a result of these fatty acids being the substrate of Delta-6 desaturase.	Fatty Acids, Unsaturated	12-35	fatty acid desaturase 2	Mus musculus	143-161
34997498-11	2022	The expression of stearoyl-CoA desaturase (SCD), ELOVL fatty acid elongase 1 (ELOVL1) promoted, and fatty acid desaturase 1 (FADS1) inhibited the key fatty acids of unsaturated fatty acids metabolism compared to the control cell group.	Fatty Acids, Unsaturated	165-188	stearoyl-CoA desaturase	Homo sapiens	18-41
35343224-8	2022	In SCD1-knockout goats, milk fat percentage and unsaturated fatty acid levels were reduced but other milk components were unchanged.	Fatty Acids, Unsaturated	48-70	stearoyl-CoA desaturase	Capra hircus	3-7
35343224-13	2022	Our observations indicated that SCD1 regulated the synthesis of milk fat and unsaturated fatty acid in goat by affecting lipid metabolism gene expression and lipid metabolic pathways.	Fatty Acids, Unsaturated	77-99	stearoyl-CoA desaturase	Capra hircus	32-36
34997498-11	2022	The expression of stearoyl-CoA desaturase (SCD), ELOVL fatty acid elongase 1 (ELOVL1) promoted, and fatty acid desaturase 1 (FADS1) inhibited the key fatty acids of unsaturated fatty acids metabolism compared to the control cell group.	Fatty Acids, Unsaturated	165-188	stearoyl-CoA desaturase	Homo sapiens	43-46
35409428-0	2022	Circ003429 Regulates Unsaturated Fatty Acid Synthesis in the Dairy Goat Mammary Gland by Interacting with miR-199a-3p, Targeting the YAP1 Gene.	Fatty Acids, Unsaturated	21-43	transcriptional coactivator YAP1	Capra hircus	133-137
35409428-10	2022	These results indicate that circ003429 alleviates the inhibitory effect of miR-199a-3p on the mRNA abundance of YAP1 by binding miR-199a-3p, resulting in subsequent regulation of the synthesis of TAG and unsaturated fatty acids.	Fatty Acids, Unsaturated	204-227	transcriptional coactivator YAP1	Capra hircus	112-116
35380736-0	2022	NMR and computational studies reveal novel aspects in molecular recognition of unsaturated fatty acids with non-labeled serum albumin.	Fatty Acids, Unsaturated	79-102	albumin	Homo sapiens	126-133
35263694-0	2022	Maternal polyunsaturated fatty acid concentrations during pregnancy and childhood liver fat accumulation.	Fatty Acids, Unsaturated	9-35	FAT atypical cadherin 1	Homo sapiens	88-91
35263694-7	2022	RESULTS: We observed that 1-Standard deviation (SD) higher maternal n-3 PUFA concentrations, especially DHA, was associated with a lower childhood liver fat fraction (-0.07 SD-score (95% CI -0.11 to -0.02, p-value = 0.001) for both total n-3 PUFA and DHA concentrations).	Fatty Acids, Unsaturated	72-76	FAT atypical cadherin 1	Homo sapiens	153-156
35149342-7	2022	High-throughput metabolomics showed that EVs derived from PKM2-activated T lymphocytes contained increased levels of polyunsaturated fatty acid (PUFA)-containing phospholipids, which may provide abundant substrates for lipid peroxidation in target macrophages.	Fatty Acids, Unsaturated	117-143	pyruvate kinase, muscle	Mus musculus	58-62
34997498-11	2022	The expression of stearoyl-CoA desaturase (SCD), ELOVL fatty acid elongase 1 (ELOVL1) promoted, and fatty acid desaturase 1 (FADS1) inhibited the key fatty acids of unsaturated fatty acids metabolism compared to the control cell group.	Fatty Acids, Unsaturated	165-188	ELOVL fatty acid elongase 1	Homo sapiens	49-76
34997498-11	2022	The expression of stearoyl-CoA desaturase (SCD), ELOVL fatty acid elongase 1 (ELOVL1) promoted, and fatty acid desaturase 1 (FADS1) inhibited the key fatty acids of unsaturated fatty acids metabolism compared to the control cell group.	Fatty Acids, Unsaturated	165-188	ELOVL fatty acid elongase 1	Homo sapiens	78-84
34997498-11	2022	The expression of stearoyl-CoA desaturase (SCD), ELOVL fatty acid elongase 1 (ELOVL1) promoted, and fatty acid desaturase 1 (FADS1) inhibited the key fatty acids of unsaturated fatty acids metabolism compared to the control cell group.	Fatty Acids, Unsaturated	165-188	fatty acid desaturase 1	Homo sapiens	100-123
34997498-11	2022	The expression of stearoyl-CoA desaturase (SCD), ELOVL fatty acid elongase 1 (ELOVL1) promoted, and fatty acid desaturase 1 (FADS1) inhibited the key fatty acids of unsaturated fatty acids metabolism compared to the control cell group.	Fatty Acids, Unsaturated	165-188	fatty acid desaturase 1	Homo sapiens	125-130
35149342-7	2022	High-throughput metabolomics showed that EVs derived from PKM2-activated T lymphocytes contained increased levels of polyunsaturated fatty acid (PUFA)-containing phospholipids, which may provide abundant substrates for lipid peroxidation in target macrophages.	Fatty Acids, Unsaturated	145-149	pyruvate kinase, muscle	Mus musculus	58-62
35105676-3	2022	Soluble epoxide hydrolase (sEH) is a key enzyme in the metabolism of polyunsaturated fatty acids, and has been shown to play a role in psychiatric disorders.	Fatty Acids, Unsaturated	69-96	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
35409000-4	2022	In addition, knockout of miR-130b promoted triacylglycerol (TAG) and cholesterol accumulation, and decreased the proportion of monounsaturated fatty acids (MUFA) C16:1, C18:1 and polyunsaturated fatty acids (PUFA) C18:2, C20:3, C20:4, C20:5, C22:6.	Fatty Acids, Unsaturated	179-206	microRNA 130b	Sus scrofa	25-33
35409000-4	2022	In addition, knockout of miR-130b promoted triacylglycerol (TAG) and cholesterol accumulation, and decreased the proportion of monounsaturated fatty acids (MUFA) C16:1, C18:1 and polyunsaturated fatty acids (PUFA) C18:2, C20:3, C20:4, C20:5, C22:6.	Fatty Acids, Unsaturated	208-212	microRNA 130b	Sus scrofa	25-33
35105676-3	2022	Soluble epoxide hydrolase (sEH) is a key enzyme in the metabolism of polyunsaturated fatty acids, and has been shown to play a role in psychiatric disorders.	Fatty Acids, Unsaturated	69-96	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
35103282-1	2022	Acyl-CoA synthetase long-chain family member 4 (ACSL4) activates polyunsaturated fatty acids (PUFAs) to produce PUFA-derived acyl-CoAs, which are utilised for the synthesis of various biological components, including phospholipids (PL).	Fatty Acids, Unsaturated	65-92	acyl-CoA synthetase long chain family member 4	Homo sapiens	0-46
35360063-8	2022	TRPC1-dependent decreases in cholesterol ester concentration with concomitant increases in long-chain polyunsaturated fatty acid -containing triacylglycerols indicate a disruption of neutral lipid homeostasis that may be tied to Ca2+ regulation.	Fatty Acids, Unsaturated	102-128	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	0-5
35129022-2	2022	12-lipoxygenase (12-LOX) is a member of lipoxygenase family responsible for the oxygenation of cellular polyunsaturated fatty acids to produce lipid mediators which modulate cell inflammation.	Fatty Acids, Unsaturated	104-131	arachidonate 15-lipoxygenase	Mus musculus	0-15
35129022-2	2022	12-lipoxygenase (12-LOX) is a member of lipoxygenase family responsible for the oxygenation of cellular polyunsaturated fatty acids to produce lipid mediators which modulate cell inflammation.	Fatty Acids, Unsaturated	104-131	arachidonate 15-lipoxygenase	Mus musculus	17-23
35090101-1	2022	AIMS: Fatty acid-binding protein (FABP) regulates polyunsaturated fatty acid (PUFA) intracellular trafficking and signal transduction.	Fatty Acids, Unsaturated	50-76	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	6-32
35090101-1	2022	AIMS: Fatty acid-binding protein (FABP) regulates polyunsaturated fatty acid (PUFA) intracellular trafficking and signal transduction.	Fatty Acids, Unsaturated	50-76	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	34-38
35090101-1	2022	AIMS: Fatty acid-binding protein (FABP) regulates polyunsaturated fatty acid (PUFA) intracellular trafficking and signal transduction.	Fatty Acids, Unsaturated	78-82	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	6-32
35090101-1	2022	AIMS: Fatty acid-binding protein (FABP) regulates polyunsaturated fatty acid (PUFA) intracellular trafficking and signal transduction.	Fatty Acids, Unsaturated	78-82	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	34-38
35327573-7	2022	Exogeneous application of poly unsaturated fatty acids (PUFAs), a product of DAG hydrolysis was demonstrated as an efficient way to activate the Drosophila TRP/TRPL channels.	Fatty Acids, Unsaturated	26-54	transient receptor potential-like	Drosophila melanogaster	160-164
35327573-7	2022	Exogeneous application of poly unsaturated fatty acids (PUFAs), a product of DAG hydrolysis was demonstrated as an efficient way to activate the Drosophila TRP/TRPL channels.	Fatty Acids, Unsaturated	56-61	transient receptor potential-like	Drosophila melanogaster	160-164
35103282-1	2022	Acyl-CoA synthetase long-chain family member 4 (ACSL4) activates polyunsaturated fatty acids (PUFAs) to produce PUFA-derived acyl-CoAs, which are utilised for the synthesis of various biological components, including phospholipids (PL).	Fatty Acids, Unsaturated	65-92	acyl-CoA synthetase long chain family member 4	Homo sapiens	48-53
35103282-1	2022	Acyl-CoA synthetase long-chain family member 4 (ACSL4) activates polyunsaturated fatty acids (PUFAs) to produce PUFA-derived acyl-CoAs, which are utilised for the synthesis of various biological components, including phospholipids (PL).	Fatty Acids, Unsaturated	65-92	pumilio RNA binding family member 3	Homo sapiens	112-116
35103282-1	2022	Acyl-CoA synthetase long-chain family member 4 (ACSL4) activates polyunsaturated fatty acids (PUFAs) to produce PUFA-derived acyl-CoAs, which are utilised for the synthesis of various biological components, including phospholipids (PL).	Fatty Acids, Unsaturated	94-99	acyl-CoA synthetase long chain family member 4	Homo sapiens	0-46
35103282-1	2022	Acyl-CoA synthetase long-chain family member 4 (ACSL4) activates polyunsaturated fatty acids (PUFAs) to produce PUFA-derived acyl-CoAs, which are utilised for the synthesis of various biological components, including phospholipids (PL).	Fatty Acids, Unsaturated	94-99	acyl-CoA synthetase long chain family member 4	Homo sapiens	48-53
35103282-1	2022	Acyl-CoA synthetase long-chain family member 4 (ACSL4) activates polyunsaturated fatty acids (PUFAs) to produce PUFA-derived acyl-CoAs, which are utilised for the synthesis of various biological components, including phospholipids (PL).	Fatty Acids, Unsaturated	94-99	pumilio RNA binding family member 3	Homo sapiens	112-116
35171671-6	2022	We show that in response to DNA damage, polyunsaturated fatty acids, especially arachidonic acid (AA) and AA-related lipid mediators, are elevated and this is dependent on mys-1.	Fatty Acids, Unsaturated	40-67	Histone acetyltransferase Tip60 homolog	Caenorhabditis elegans	172-177
35157107-6	2022	Both concentration and composition of the SFA and SFA plus n-3 polyunsaturated fatty acids (PUFA) mixtures had significant effects on genes involved in the PI3K/Akt pathway.	Fatty Acids, Unsaturated	92-96	AKT serine/threonine kinase 1	Homo sapiens	161-164
35169201-8	2022	Finally, lipidomic analysis revealed that loss of Pxmp4 decreased hepatic levels of the alkyldiacylglycerol class of neutral ether lipids, particularly those containing polyunsaturated fatty acids.	Fatty Acids, Unsaturated	169-196	peroxisomal membrane protein 4	Mus musculus	50-55
35173269-2	2022	Linoleic and alpha-linolenic acids need to be provided in the diet and they are converted into long chain polyunsaturated fatty acids by steps of elongation and desaturation, exerted by elongases 2 (ELOVL2) and 5 (ELOVL5) and Delta5- (FADS1) and Delta6-desaturase (FADS2).	Fatty Acids, Unsaturated	106-133	elongation of very long chain fatty acids protein 2	Oryctolagus cuniculus	199-205
35173269-2	2022	Linoleic and alpha-linolenic acids need to be provided in the diet and they are converted into long chain polyunsaturated fatty acids by steps of elongation and desaturation, exerted by elongases 2 (ELOVL2) and 5 (ELOVL5) and Delta5- (FADS1) and Delta6-desaturase (FADS2).	Fatty Acids, Unsaturated	106-133	elongation of very long chain fatty acids protein 5	Oryctolagus cuniculus	214-220
35173269-2	2022	Linoleic and alpha-linolenic acids need to be provided in the diet and they are converted into long chain polyunsaturated fatty acids by steps of elongation and desaturation, exerted by elongases 2 (ELOVL2) and 5 (ELOVL5) and Delta5- (FADS1) and Delta6-desaturase (FADS2).	Fatty Acids, Unsaturated	106-133	LOW QUALITY PROTEIN: fatty acid desaturase 1	Oryctolagus cuniculus	235-240
35173269-2	2022	Linoleic and alpha-linolenic acids need to be provided in the diet and they are converted into long chain polyunsaturated fatty acids by steps of elongation and desaturation, exerted by elongases 2 (ELOVL2) and 5 (ELOVL5) and Delta5- (FADS1) and Delta6-desaturase (FADS2).	Fatty Acids, Unsaturated	106-133	acyl-CoA 6-desaturase	Oryctolagus cuniculus	265-270
35135573-12	2022	Abnormal lipid accumulation, changes of gene expression profile and upregulation of multi-component mechanistic target of rapamycin complex 1 (mTOR)/Peroxisome proliferator-activated receptor-gamma pathway was observed in liver, accompanied with decreased bile acids level, unsaturated fatty acids androgens and prostaglandins in serum.	Fatty Acids, Unsaturated	274-297	mechanistic target of rapamycin kinase	Mus musculus	143-147
35222477-4	2022	Next, the remodeling enzyme Per1p (Post-Glycosylphosphatidylinositol Attachment to Proteins phospholipase 3 -PGAP3- in mammals) removes a short, unsaturated fatty acid of phosphatidylinositol (PI) that is replaced with a very long-chain saturated fatty acid or ceramide to complete lipid remodeling.	Fatty Acids, Unsaturated	145-167	1-cysteine peroxiredoxin 1	Arabidopsis thaliana	28-33
35173457-0	2022	Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration.	Fatty Acids, Unsaturated	11-38	renin binding protein	Homo sapiens	86-89
35211495-3	2021	Interactions are particularly relevant with the FADS1 and FADS2 genes, which encode key fatty acid desaturases in the pathway that converts LA and ALA to their long chain (>=20 carbons), highly unsaturated fatty acid (HUFA) counterparts.	Fatty Acids, Unsaturated	194-216	fatty acid desaturase 1	Homo sapiens	48-53
35211495-3	2021	Interactions are particularly relevant with the FADS1 and FADS2 genes, which encode key fatty acid desaturases in the pathway that converts LA and ALA to their long chain (>=20 carbons), highly unsaturated fatty acid (HUFA) counterparts.	Fatty Acids, Unsaturated	194-216	fatty acid desaturase 2	Homo sapiens	58-63
35208997-4	2022	The valuable biological properties of chia seeds are related to their rich chemical composition, with particularly high content of polyunsaturated fatty acids, essential amino acids, polyphenols, as well as vitamins and bioelements.	Fatty Acids, Unsaturated	131-158	chitinase acidic	Homo sapiens	38-42
35135573-12	2022	Abnormal lipid accumulation, changes of gene expression profile and upregulation of multi-component mechanistic target of rapamycin complex 1 (mTOR)/Peroxisome proliferator-activated receptor-gamma pathway was observed in liver, accompanied with decreased bile acids level, unsaturated fatty acids androgens and prostaglandins in serum.	Fatty Acids, Unsaturated	274-297	peroxisome proliferator activated receptor gamma	Mus musculus	149-197
35040258-2	2022	The Fat-1 gene can express the n-3 fatty acid desaturase, which converts n-6 polyunsaturated fatty acids (PUFA) to n-3 PUFAs.	Fatty Acids, Unsaturated	106-110	LOW QUALITY PROTEIN: protocadherin Fat 1	Oryctolagus cuniculus	4-9
35276915-1	2022	The fatty acid elongase elongation of very long-chain fatty acids protein 2 (ELOVL2) controls the elongation of polyunsaturated fatty acids (PUFA) producing precursors for omega-3, docosahexaenoic acid (DHA), and omega-6, docosapentaenoic acid (DPAn-6) in vivo.	Fatty Acids, Unsaturated	112-139	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	Mus musculus	77-83
35159548-0	2022	Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile.	Fatty Acids, Unsaturated	28-55	CD36 molecule	Mus musculus	121-124
35276915-1	2022	The fatty acid elongase elongation of very long-chain fatty acids protein 2 (ELOVL2) controls the elongation of polyunsaturated fatty acids (PUFA) producing precursors for omega-3, docosahexaenoic acid (DHA), and omega-6, docosapentaenoic acid (DPAn-6) in vivo.	Fatty Acids, Unsaturated	141-145	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	Mus musculus	77-83
35276817-0	2022	Association between FADS Gene Expression and Polyunsaturated Fatty Acids in Breast Milk.	Fatty Acids, Unsaturated	45-72	stearoyl-CoA desaturase	Homo sapiens	20-24
35057499-7	2022	Compared to low levels of consumption, a positive association was observed between high polyunsaturated fatty acids (PUFA) consumption (>16.9 g/day) and prevalence of KRAS mutations (OR = 2.15, 95% CI = 1.01-4.59).	Fatty Acids, Unsaturated	88-115	KRAS proto-oncogene, GTPase	Homo sapiens	167-171
35057499-7	2022	Compared to low levels of consumption, a positive association was observed between high polyunsaturated fatty acids (PUFA) consumption (>16.9 g/day) and prevalence of KRAS mutations (OR = 2.15, 95% CI = 1.01-4.59).	Fatty Acids, Unsaturated	117-121	KRAS proto-oncogene, GTPase	Homo sapiens	167-171
35082691-11	2021	In huCETP females, CETP in the circulation decreased HDL-cholesterol content and increased liver cholesterol uptake and liver cholesterol and oxysterol contents, which was associated with the upregulation of LXR target genes in long-chain polyunsaturated fatty acid biosynthesis and PPARalpha target genes in fatty acid beta-oxidation in the liver.	Fatty Acids, Unsaturated	239-265	cholesteryl ester transfer protein	Homo sapiens	19-23
35082691-11	2021	In huCETP females, CETP in the circulation decreased HDL-cholesterol content and increased liver cholesterol uptake and liver cholesterol and oxysterol contents, which was associated with the upregulation of LXR target genes in long-chain polyunsaturated fatty acid biosynthesis and PPARalpha target genes in fatty acid beta-oxidation in the liver.	Fatty Acids, Unsaturated	239-265	nuclear receptor subfamily 1, group H, member 3	Mus musculus	208-211
35013389-1	2022	GPR120 (encoded by FFAR4 gene) is a receptor for long chain fatty acids, activated by omega-3 Polyunsaturated Fatty Acids (PUFAs), and expressed in many cell types.	Fatty Acids, Unsaturated	123-128	free fatty acid receptor 4	Mus musculus	19-24
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Fatty Acids, Unsaturated	522-545	glutathione peroxidase 4	Homo sapiens	134-158
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Fatty Acids, Unsaturated	522-545	glutathione peroxidase 4	Homo sapiens	159-163
35013389-1	2022	GPR120 (encoded by FFAR4 gene) is a receptor for long chain fatty acids, activated by omega-3 Polyunsaturated Fatty Acids (PUFAs), and expressed in many cell types.	Fatty Acids, Unsaturated	123-128	free fatty acid receptor 4	Mus musculus	0-6
34986331-3	2022	We reveal that the STING (stimulator of interferon genes) protein regulates metabolic homeostasis through inhibition of the fatty acid desaturase 2 (FADS2) rate-limiting enzyme in polyunsaturated fatty acid (PUFA) desaturation.	Fatty Acids, Unsaturated	180-206	fatty acid desaturase 2	Homo sapiens	124-147
35071379-8	2021	ACSF3 played a pivotal role in the regulation of cellular triacylglycerol and long-chain polyunsaturated fatty acid levels, and polymorphism could serve as a useful molecular marker for future marker-assisted selection in the breeding of intramuscular fat deposition traits in beef cattle.	Fatty Acids, Unsaturated	89-115	acyl-CoA synthetase family member 3	Bos taurus	0-5
34986331-3	2022	We reveal that the STING (stimulator of interferon genes) protein regulates metabolic homeostasis through inhibition of the fatty acid desaturase 2 (FADS2) rate-limiting enzyme in polyunsaturated fatty acid (PUFA) desaturation.	Fatty Acids, Unsaturated	180-206	fatty acid desaturase 2	Homo sapiens	149-154
34986331-3	2022	We reveal that the STING (stimulator of interferon genes) protein regulates metabolic homeostasis through inhibition of the fatty acid desaturase 2 (FADS2) rate-limiting enzyme in polyunsaturated fatty acid (PUFA) desaturation.	Fatty Acids, Unsaturated	208-212	fatty acid desaturase 2	Homo sapiens	124-147
34986331-3	2022	We reveal that the STING (stimulator of interferon genes) protein regulates metabolic homeostasis through inhibition of the fatty acid desaturase 2 (FADS2) rate-limiting enzyme in polyunsaturated fatty acid (PUFA) desaturation.	Fatty Acids, Unsaturated	208-212	fatty acid desaturase 2	Homo sapiens	149-154
34986331-4	2022	STING ablation and agonist-mediated degradation increased FADS2-associated desaturase activity and led to accumulation of PUFA derivatives that drive thermogenesis.	Fatty Acids, Unsaturated	122-126	fatty acid desaturase 2	Homo sapiens	58-63
2674136-1	1989	The unsaturated fatty acid (ufa) requiring ole1 mutant of Saccharomyces cerevisiae appears to produce a defective delta-9 fatty acid desaturase.	Fatty Acids, Unsaturated	4-26	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	43-47
2556389-0	1989	Lipid peroxyl radical intermediates in the peroxidation of polyunsaturated fatty acids by lipoxygenase.	Fatty Acids, Unsaturated	59-86	linoleate 9S-lipoxygenase-4	Glycine max	90-102
2556389-2	1989	Lipid peroxyl radicals resulting from the peroxidation of polyunsaturated fatty acids by soybean lipoxygenase were directly detected by the method of rapid mixing, continuous-flow electron spin resonance spectroscopy.	Fatty Acids, Unsaturated	58-85	linoleate 9S-lipoxygenase-4	Glycine max	97-109
2530278-7	1989	The results suggest that elevated incorporation of polyunsaturated fatty acids and thus continuous activation and translocation of PKC represents a necessary early signal for IL-2 synthesis and proliferation in human lymphocytes.	Fatty Acids, Unsaturated	51-78	interleukin 2	Homo sapiens	175-179
2530278-1	1989	Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C. Human PBL activated with anti-TCR/CD3 mAb express high affinity receptors for IL-2, synthesize IL-2, and subsequently proliferate.	Fatty Acids, Unsaturated	17-44	interleukin 2	Homo sapiens	90-94
2530278-1	1989	Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C. Human PBL activated with anti-TCR/CD3 mAb express high affinity receptors for IL-2, synthesize IL-2, and subsequently proliferate.	Fatty Acids, Unsaturated	17-44	interleukin 2	Homo sapiens	229-233
2530278-1	1989	Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C. Human PBL activated with anti-TCR/CD3 mAb express high affinity receptors for IL-2, synthesize IL-2, and subsequently proliferate.	Fatty Acids, Unsaturated	17-44	interleukin 2	Homo sapiens	229-233
2530278-5	1989	In lymphocytes activated by antiTCR/CD3 mAb translocation of PKC is detectable after 15 min, then it declines to control levels, followed by a second, long lasting activation of the enzyme up to 4 h. Addition of polyunsaturated fatty acids to DiC8 + ionomycin-treated cells leads to IL-2 synthesis and proliferation.	Fatty Acids, Unsaturated	212-239	interleukin 2	Homo sapiens	283-287
2674136-1	1989	The unsaturated fatty acid (ufa) requiring ole1 mutant of Saccharomyces cerevisiae appears to produce a defective delta-9 fatty acid desaturase.	Fatty Acids, Unsaturated	28-31	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	43-47
2674136-3	1989	A DNA fragment isolated by complementation of an ole1 strain repairs the ufa requirement in mutant cells.	Fatty Acids, Unsaturated	73-76	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	49-53
2774564-4	1989	In the absence of ascorbate, myoglobin and H2O2 promote the peroxidation of unsaturated fatty acids and, thus, may cause damage to cellular constituents.	Fatty Acids, Unsaturated	76-99	myoglobin	Homo sapiens	29-38
2505853-0	1989	Metabolism of unsaturated fatty acids by RBL-1 5-lipoxygenase: influence of substrate solubility and product inactivation.	Fatty Acids, Unsaturated	14-37	RB transcriptional corepressor like 1	Rattus norvegicus	41-46
2505853-0	1989	Metabolism of unsaturated fatty acids by RBL-1 5-lipoxygenase: influence of substrate solubility and product inactivation.	Fatty Acids, Unsaturated	14-37	arachidonate 5-lipoxygenase	Rattus norvegicus	47-61
2505852-5	1989	These findings suggest that liberation of unsaturated fatty acids from membrane phospholipids, as a consequence of phospholipase A2 activation, would modulate PAF formation via inhibition of the acetyltransferase.	Fatty Acids, Unsaturated	42-65	LOC104974671	Bos taurus	115-131
2570068-9	1989	SCD2 mRNA is expressed constitutively at a high level in brain, is not expressed in liver, and its expression in kidney, adipose, and lung tissue is increased greatly by shifting mice from a diet containing unsaturated fatty acids to a diet devoid of fat.	Fatty Acids, Unsaturated	207-230	stearoyl-Coenzyme A desaturase 2	Mus musculus	0-4
2570068-10	1989	The tissue distribution and the dietary alteration of SCD1 mRNA expression differs markedly from that of SCD2 mRNA being absent from brain, constitutive in adipose tissue, and subject to negative control in liver by feeding a diet containing unsaturated fatty acids.	Fatty Acids, Unsaturated	242-265	stearoyl-Coenzyme A desaturase 1	Mus musculus	54-58
2475177-2	1989	Scatchard analysis of estradiol (E2) binding to purified rat AFP indicated that unsaturated fatty acids changed the number of binding E2 sites and the apparent E2 equilibrium dissociation constant which varied non-linearly with docosahexaenoic acid concentration.	Fatty Acids, Unsaturated	80-103	alpha-fetoprotein	Rattus norvegicus	61-64
2606905-6	1989	External addition of the ATP-analog, EGTA, and inhibitors of phospholipase A2 suppressed the liberation of non-esterified polyunsaturated fatty acids.	Fatty Acids, Unsaturated	122-149	phospholipase A2 group IB	Homo sapiens	61-77
2475177-3	1989	UV spectral analysis of rodent and human AFPs showed that the absorbance minimum of AFP incubated with unsaturated fatty acid (L-AFP) was red-shifted, broadened and less pronounced than that of purified native AFP (N-AFP).	Fatty Acids, Unsaturated	103-125	alpha fetoprotein	Homo sapiens	41-44
2475177-3	1989	UV spectral analysis of rodent and human AFPs showed that the absorbance minimum of AFP incubated with unsaturated fatty acid (L-AFP) was red-shifted, broadened and less pronounced than that of purified native AFP (N-AFP).	Fatty Acids, Unsaturated	103-125	alpha fetoprotein	Homo sapiens	84-87
2617942-4	1989	The diet of coast Chuchkchee land inhabitants, involving the higher level of unsaturated fatty acids n-3, resulted in the higher ratio between HDL cholesterol and apoA-I, in the higher part of unsaturated fatty acids n-3 in blood plasma lipids (phospholipids and cholesterol esters) and erythrocytes; it led to a relative increase of sphingomyelin and phosphatidyl-ethanolamine and to a decrease of phosphatidylcholine in HDL subfractions.	Fatty Acids, Unsaturated	77-100	apolipoprotein A1	Homo sapiens	163-169
2475177-3	1989	UV spectral analysis of rodent and human AFPs showed that the absorbance minimum of AFP incubated with unsaturated fatty acid (L-AFP) was red-shifted, broadened and less pronounced than that of purified native AFP (N-AFP).	Fatty Acids, Unsaturated	103-125	alpha fetoprotein	Homo sapiens	84-87
2475177-3	1989	UV spectral analysis of rodent and human AFPs showed that the absorbance minimum of AFP incubated with unsaturated fatty acid (L-AFP) was red-shifted, broadened and less pronounced than that of purified native AFP (N-AFP).	Fatty Acids, Unsaturated	103-125	alpha fetoprotein	Homo sapiens	84-87
2475177-4	1989	Immunochemical studies with specific polyclonal antibodies to purified rodent and human AFPs (N-AFP antibodies) showed that these proteins lost immunoreactivity after incubation with unsaturated fatty acid.	Fatty Acids, Unsaturated	183-205	alpha fetoprotein	Homo sapiens	88-91
2475177-9	1989	RIA or ELISA values for human AFP from fetal serum, hepatoma serum, and cord serum, were reduced 80, 50 and 5%, respectively, by unsaturated fatty acids.	Fatty Acids, Unsaturated	129-152	alpha fetoprotein	Homo sapiens	30-33
2475177-11	1989	Such results indicate that an unsaturated fatty acid environment induces conformational changes in AFP which may modulate the endocrine and immune functions of this protein.	Fatty Acids, Unsaturated	30-52	alpha fetoprotein	Homo sapiens	99-102
2787317-5	1989	alpha 1-PI in solutions containing phosphate buffer (control), 0.1 mM stearic acid (saturated fatty acid, 18:0), or 0.1 mM linoleic acid (polyunsaturated fatty acid, 18:2) was exposed to either N2 or NO2 (50 ppm for 4 h).	Fatty Acids, Unsaturated	138-164	serpin family A member 1	Homo sapiens	0-10
2498379-7	1989	The binding of T4 to apoA-I was reduced by known inhibitors of T4 binding to serum proteins (diclofenac = mefenamic acid = furosemide = 8-anilinonaphthalene sulfonic acid much greater than dilantin greater than heparin greater than barbital) and by lipids (unsaturated fatty acids greater than cholesterol = cholesterol esters = phospholipids greater than saturated fatty acids = diglycerides = triglycerides).	Fatty Acids, Unsaturated	257-280	apolipoprotein A1	Homo sapiens	21-27
2766482-2	1989	Recently, a new extracellular pool of unsaturated fatty acids including arachidonate has been found in relation to group-specific component (Gc), a vitamin D-binding plasma protein that sequesters monomeric G-actin.	Fatty Acids, Unsaturated	38-61	GC, vitamin D binding protein	Rattus norvegicus	115-147
2502779-2	1989	During the aerobic reaction of soybean lipoxygenase with polyunsaturated fatty acids (linoleic, linolenic, and arachidonic acid) oxygen uptake is followed by excited carbonyl photoemission.	Fatty Acids, Unsaturated	57-84	linoleate 9S-lipoxygenase-4	Glycine max	39-51
2778805-8	1989	Similarity of the FFA induced effects on 3H-QNB binding to sarcolemmal muscarinic receptors to those induced by PLA2 suggest that membrane accumulation of unsaturated fatty acids underlies in part the effect of PLA2.	Fatty Acids, Unsaturated	155-178	phospholipase A2 group IB	Canis lupus familiaris	112-116
2778805-8	1989	Similarity of the FFA induced effects on 3H-QNB binding to sarcolemmal muscarinic receptors to those induced by PLA2 suggest that membrane accumulation of unsaturated fatty acids underlies in part the effect of PLA2.	Fatty Acids, Unsaturated	155-178	phospholipase A2 group IB	Canis lupus familiaris	211-215
2786546-7	1989	Significant correlations were obtained between the polyunsaturated fatty acids and the high density lipoprotein cholesterol or apolipoprotein A-I in the control subjects but most of these correlations were absent in the patients.	Fatty Acids, Unsaturated	51-78	apolipoprotein A1	Homo sapiens	127-145
2907482-8	1988	The individual components of serum-free medium which proved to support vimentin induction by TPA were insulin and the unsaturated fatty acids oleic acid and linoleic acid.	Fatty Acids, Unsaturated	118-141	vimentin	Mus musculus	71-79
2482082-11	1989	These results agree with recent experimental data suggesting that the major physiological role of AFP is the transport and delivery of polyunsaturated fatty acids to developing tissues.	Fatty Acids, Unsaturated	135-162	alpha fetoprotein	Mus musculus	98-101
2494162-5	1989	LDL also has a phospholipase A2 activity that is specific for oxidized polyunsaturated fatty acids, which may be important in determining how LDL is recognized by cellular receptors.	Fatty Acids, Unsaturated	71-98	phospholipase A2 group IB	Homo sapiens	15-31
2466459-8	1989	The possible role of AFP synthesis in lymphocyte blastogenesis and in lymphoma growth is discussed in relation with the strong binding affinity of this protein for polyunsaturated fatty acids.	Fatty Acids, Unsaturated	164-191	alpha fetoprotein	Homo sapiens	21-24
2537393-1	1989	The effects of incorporation of dietary n-3 polyunsaturated fatty acids (PUFA) into rat liver plasma membrane on the activity of 5"-nucleotidase (EC 3.1.3.5) was studied.	Fatty Acids, Unsaturated	73-77	5' nucleotidase, ecto	Rattus norvegicus	129-144
2541151-1	1989	In the reaction of soybean lipoxygenase (EC 1.13.11.12) with polyunsaturated fatty acids such as linoleic, linolenic and arachidonic acids, some radical species were detected using the electron spin resonance (ESR) spin-trapping technique.	Fatty Acids, Unsaturated	61-88	linoleate 9S-lipoxygenase-4	Glycine max	27-39
2653575-1	1989	The 5-lipoxygenase pathway for the oxidative metabolism of unsaturated fatty acids was first recognized less than 10 years ago with the definition of 5-S hydroxy eicosatetraenoic acid (5-HETE) as a product, and its potential biological relevance to inflammation was suggested solely by the modest chemotactic activity of this compound.	Fatty Acids, Unsaturated	59-82	arachidonate 5-lipoxygenase	Homo sapiens	4-18
3148797-8	1988	These results thus support the hypothesis that the acyl specificity of polyunsaturated fatty acid release is provided by the agonist-stimulated phospholipase A2 rather than the composition of the alkylacyl-GPC.	Fatty Acids, Unsaturated	71-97	phospholipase A2 group IB	Homo sapiens	144-160
3142242-0	1988	Reduction in plasminogen activator inhibitor-1 (PAI-1) with omega-3 polyunsaturated fatty acid (PUFA) intake.	Fatty Acids, Unsaturated	96-100	serpin family E member 1	Homo sapiens	13-46
3142242-0	1988	Reduction in plasminogen activator inhibitor-1 (PAI-1) with omega-3 polyunsaturated fatty acid (PUFA) intake.	Fatty Acids, Unsaturated	96-100	serpin family E member 1	Homo sapiens	48-53
3142242-8	1988	This study shows that omega-3 PUFA intake reduces PAI-1 levels without change in TPA antigen.	Fatty Acids, Unsaturated	30-34	serpin family E member 1	Homo sapiens	50-55
3060987-1	1988	The effect on plasma antithrombin III (AT III) and protein C on a supplement with polyunsaturated fatty acids (PUFA"s) was investigated in a double-blind study in 36 patients with stable angina pectoris.	Fatty Acids, Unsaturated	82-109	serpin family C member 1	Homo sapiens	21-37
3173114-6	1988	Evaporated ether extracts of rat liver homogenate pretreated with phospholipase A2 for five to 20 minutes (that liberates unsaturated fatty acids from phospholipids) demonstrated a progressive inhibition of nuclear T3 binding with time when compared with ether extracts of untreated rat liver homogenate (F = 16.1; P less than .01).	Fatty Acids, Unsaturated	122-145	phospholipase A2 group IB	Rattus norvegicus	66-82
3221873-0	1988	Calcium-independent activation of hypothalamic type I protein kinase C by unsaturated fatty acids.	Fatty Acids, Unsaturated	74-97	proline rich transmembrane protein 2	Homo sapiens	54-70
3138949-1	1988	The rabbit reticulocyte lipoxygenase is known to display an unusual facility for oxygenation of esterified polyunsaturated fatty acids, yet the precise structures of the products are not known.	Fatty Acids, Unsaturated	107-134	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	24-36
3178736-9	1988	The albumin-released lysophosphatidylcholine was enriched in unsaturated fatty acids.	Fatty Acids, Unsaturated	61-84	albumin	Rattus norvegicus	4-11
3135173-4	1988	Unsaturated fatty acids (UFA) had a dose-dependent inhibitory effect (P less than 0.001) on steroid binding to CBG which was offset by saturated fatty acid-induced potentiation of binding (P less than 0.01) when both were present with CBG.	Fatty Acids, Unsaturated	0-23	serpin family A member 6	Homo sapiens	111-114
3142479-6	1988	The possibility discussed here is that two distinct peroxidative mechanisms (of which one, NADPH-cytochrome P-450 reductase-dependent, is influenced by the thyroid hormone) can compete with each other for the substrate polyunsaturated fatty acids.	Fatty Acids, Unsaturated	219-246	cytochrome p450 oxidoreductase	Rattus norvegicus	91-123
3135173-4	1988	Unsaturated fatty acids (UFA) had a dose-dependent inhibitory effect (P less than 0.001) on steroid binding to CBG which was offset by saturated fatty acid-induced potentiation of binding (P less than 0.01) when both were present with CBG.	Fatty Acids, Unsaturated	0-23	serpin family A member 6	Homo sapiens	235-238
3135173-4	1988	Unsaturated fatty acids (UFA) had a dose-dependent inhibitory effect (P less than 0.001) on steroid binding to CBG which was offset by saturated fatty acid-induced potentiation of binding (P less than 0.01) when both were present with CBG.	Fatty Acids, Unsaturated	25-28	serpin family A member 6	Homo sapiens	111-114
3135173-4	1988	Unsaturated fatty acids (UFA) had a dose-dependent inhibitory effect (P less than 0.001) on steroid binding to CBG which was offset by saturated fatty acid-induced potentiation of binding (P less than 0.01) when both were present with CBG.	Fatty Acids, Unsaturated	25-28	serpin family A member 6	Homo sapiens	235-238
3135173-12	1988	Immunoelectrophoresis and immunoautoradiography showed a reduction, or loss, of CBG immunoreactivity in the presence of UFA.	Fatty Acids, Unsaturated	120-123	serpin family A member 6	Homo sapiens	80-83
3137235-2	1988	Previous work in our laboratory has demonstrated that the thrombin-stimulated deacylation is specific for arachidonate and structurally similar polyunsaturated fatty acids that contain a delta-5 double bond.	Fatty Acids, Unsaturated	144-171	coagulation factor II, thrombin	Homo sapiens	58-66
2451542-8	1988	These results support a specialized role of AFP in the plasma transport and tissue delivery of polyunsaturated fatty acids, and mainly docosahexaenoic acid.	Fatty Acids, Unsaturated	95-122	alpha-fetoprotein	Rattus norvegicus	44-47
3360811-12	1988	The present findings suggested that lyso-PC, likely derived from membrane PC by the action of phospholipase A2, might play a role in signal transduction via a dual regulation of protein kinase C, and that it could further modulate the enzyme and hence the cellular activity by interplaying with diacylglycerol and unsaturated fatty acid, the two other classes of cellular mediators also shown to be activators of protein kinase C.	Fatty Acids, Unsaturated	314-336	phospholipase A2 group IB	Rattus norvegicus	94-110
3232343-1	1988	Polyunsaturated fatty acids included into animals" ration (10% of linethol) intensified lipid peroxidation and increased the activity of cathepsin D, an enzyme responsible for protein and lipid degradation in the cell.	Fatty Acids, Unsaturated	0-27	cathepsin D	Homo sapiens	137-148
3397422-7	1988	Milk fat from cows fed regular sunflower seeds contained the highest proportions of unsaturated fatty acids with the lowest proportions from cows fed the control diet.	Fatty Acids, Unsaturated	84-107	Weaning weight-maternal milk	Bos taurus	0-4
3126237-7	1988	These data suggest that the relative lack of synthesis of LT from exogenous AA is related to the ability of this unsaturated fatty acid to function as an inhibitor, as well as a substrate, of 5-lipoxygenase.	Fatty Acids, Unsaturated	113-135	arachidonate 5-lipoxygenase	Rattus norvegicus	192-206
3349456-1	1988	The primary autoxidation products of polyunsaturated fatty acids are known to stimulate DNA synthesis and induce ornithine decarboxylase activity in colonic mucosa.	Fatty Acids, Unsaturated	37-64	ornithine decarboxylase 1	Homo sapiens	113-136
2833268-9	1988	These data demonstrate that in our experiments PBR binding was inhibited by specific lipids and that binding of proposed agonist (RO 5-4864) and antagonist (PK 11195) ligands was differentially affected by unsaturated fatty acids.	Fatty Acids, Unsaturated	206-229	translocator protein	Rattus norvegicus	47-50
2853315-2	1988	mu CANP, low calcium ion (microM concentration)-requiring CANP is more strongly inhibited by unsaturated fatty acids than is mCANP--the high calcium ion (mM concentration)-requiring form.	Fatty Acids, Unsaturated	93-116	calpain 1	Homo sapiens	3-7
2853315-2	1988	mu CANP, low calcium ion (microM concentration)-requiring CANP is more strongly inhibited by unsaturated fatty acids than is mCANP--the high calcium ion (mM concentration)-requiring form.	Fatty Acids, Unsaturated	93-116	calpain 1	Homo sapiens	58-62
3360876-6	1988	This approach makes possible the analysis of various derivatives generated by thrombin-stimulated platelets (10(9) cells) pre-enriched with minor polyunsaturated fatty acids, even when these derivatives co-elute from the column (e.g., 12-HETE and 14-OH-22:6).	Fatty Acids, Unsaturated	146-173	coagulation factor II, thrombin	Homo sapiens	78-86
3351636-1	1988	We have studied the effects of polyunsaturated fatty acid and its metabolism on the activity, relative synthesis and mRNA levels for rat hepatic glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD).	Fatty Acids, Unsaturated	31-57	glucose-6-phosphate dehydrogenase	Rattus norvegicus	145-178
3351636-1	1988	We have studied the effects of polyunsaturated fatty acid and its metabolism on the activity, relative synthesis and mRNA levels for rat hepatic glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD).	Fatty Acids, Unsaturated	31-57	glucose-6-phosphate dehydrogenase	Rattus norvegicus	180-184
3260860-4	1988	But unsaturated fatty acids such as oleic acid (18:1), arachidonic acid (20:4) and docosahexaenoic acid (22:6) inhibited the binding between androgen receptor and 3H-R1881.	Fatty Acids, Unsaturated	4-27	androgen receptor	Rattus norvegicus	141-158
3337815-5	1988	The effects of phospholipase A2 on receptor structure can be (i) reversed by using bovine serum albumin as a scavenger of phospholipase hydrolysis products of membrane phospholipids, and (ii) stimulated by incorporation into the membranes of free, polyunsaturated fatty acids.	Fatty Acids, Unsaturated	248-275	phospholipase A2 group IB	Homo sapiens	15-31
3333530-6	1987	For both systolic (SBP) and diastolic (DBP) blood pressure, change in polyunsaturated fatty acid intake was the strongest dietary predictor of BP change.	Fatty Acids, Unsaturated	70-96	selenium binding protein 1	Homo sapiens	19-22
3238172-6	1988	Polyunsaturated fatty acids in PLm (18:2 (n-6), 20:4 (n-6), 22:6 (n-3) acids) decreased abruptly during the first 3 days of fat deficiency and then remained rather stable till day 7.	Fatty Acids, Unsaturated	0-27	phospholamban	Rattus norvegicus	31-34
3333530-6	1987	For both systolic (SBP) and diastolic (DBP) blood pressure, change in polyunsaturated fatty acid intake was the strongest dietary predictor of BP change.	Fatty Acids, Unsaturated	70-96	D-box binding PAR bZIP transcription factor	Homo sapiens	39-42
3122822-1	1987	Lipoxygenase, a nonheme iron dioxygenase, catalyzes the oxygenation of 1,4-diene units in polyunsaturated fatty acids, forming conjugated diene hydroperoxides as the primary products.	Fatty Acids, Unsaturated	90-117	linoleate 9S-lipoxygenase-4	Glycine max	0-12
3431018-11	1987	We conclude from this study that in obese adolescents a hypocaloric diet enriched with polyunsaturated fatty acids is associated with a reduction of total-, LDL-C and Apo B concentrations, but with no major changes of HDL-C levels.	Fatty Acids, Unsaturated	87-114	apolipoprotein B	Homo sapiens	167-172
3663714-6	1987	All the unsaturated fatty acids only slightly inhibited the arachidonic acid liberation by phospholipase A2 in platelet lysate.	Fatty Acids, Unsaturated	8-31	phospholipase A2	Oryctolagus cuniculus	91-107
3553183-16	1987	L-FABP exhibited a relatively higher affinity for unsaturated fatty acids (oleate, arachidonate) than for saturated fatty acid (palmitate).	Fatty Acids, Unsaturated	50-73	fatty acid binding protein 1	Rattus norvegicus	0-6
2829281-1	1987	Arachidonic Acid (AA) released from membrane phospholipids by phospholipase A2 during cell activation is the major polyunsaturated fatty acid precursor in mammals for the cyclooxygenase and lipoxygenase pathways.	Fatty Acids, Unsaturated	115-141	phospholipase A2 group IB	Rattus norvegicus	62-78
2439321-7	1987	Similarly, E2 bound to rat alpha-fetoprotein (AFP) and unsaturated fatty acids bound to both human and rat AFP, but none of the E2 esters bound to AFP of either species.	Fatty Acids, Unsaturated	55-78	alpha-fetoprotein	Rattus norvegicus	107-110
2439321-7	1987	Similarly, E2 bound to rat alpha-fetoprotein (AFP) and unsaturated fatty acids bound to both human and rat AFP, but none of the E2 esters bound to AFP of either species.	Fatty Acids, Unsaturated	55-78	alpha-fetoprotein	Rattus norvegicus	107-110
3801503-0	1987	Apparent specificity of the thrombin-stimulated deacylation of endothelial glycerolipids for polyunsaturated fatty acids with a delta-5 desaturation.	Fatty Acids, Unsaturated	93-120	coagulation factor II, thrombin	Homo sapiens	28-36
3592634-2	1987	The saturated (18:0) and monounsaturated (cis C18:1n-9) fatty acids exhibited no cytotoxic effects, while cis polyunsaturated fatty acids (C18:2n-6, C18:3n-6, C18:3n-3, C20:4n-6, C20:5n-3 and C22:6n-3) were cytotoxic dose-dependently.	Fatty Acids, Unsaturated	110-137	Bardet-Biedl syndrome 9	Homo sapiens	139-142
3592634-2	1987	The saturated (18:0) and monounsaturated (cis C18:1n-9) fatty acids exhibited no cytotoxic effects, while cis polyunsaturated fatty acids (C18:2n-6, C18:3n-6, C18:3n-3, C20:4n-6, C20:5n-3 and C22:6n-3) were cytotoxic dose-dependently.	Fatty Acids, Unsaturated	110-137	Bardet-Biedl syndrome 9	Homo sapiens	139-142
3592634-2	1987	The saturated (18:0) and monounsaturated (cis C18:1n-9) fatty acids exhibited no cytotoxic effects, while cis polyunsaturated fatty acids (C18:2n-6, C18:3n-6, C18:3n-3, C20:4n-6, C20:5n-3 and C22:6n-3) were cytotoxic dose-dependently.	Fatty Acids, Unsaturated	110-137	Bardet-Biedl syndrome 9	Homo sapiens	139-142
3577767-5	1987	Addition of either of the unsaturated fatty acids 18:2 or 20:5 together with 18:0 eliminated the potentiating effect 18:0 by itself had on TNF-induced cytolysis.	Fatty Acids, Unsaturated	26-49	tumor necrosis factor	Mus musculus	139-142
3131072-11	1987	A possible mechanism of action of TNF is the release and metabolism of polyunsaturated fatty acids, which would explain the synthesis of prostaglandins and leukotrienes by many cell types after TNF treatment.	Fatty Acids, Unsaturated	71-98	tumor necrosis factor	Mus musculus	34-37
3799504-3	1987	PUFA was increased in polyunsaturated fatty acids but fat level remained the same.	Fatty Acids, Unsaturated	22-49	pumilio RNA binding family member 3	Homo sapiens	0-4
3131072-11	1987	A possible mechanism of action of TNF is the release and metabolism of polyunsaturated fatty acids, which would explain the synthesis of prostaglandins and leukotrienes by many cell types after TNF treatment.	Fatty Acids, Unsaturated	71-98	tumor necrosis factor	Mus musculus	194-197
3769049-3	1986	Within a few minutes after administering CCl4 to a rat there is a pronounced signal in microsomal lipid extracts that is ascribed to the cis-trans diene conjugates of microsomal polyunsaturated fatty acids.	Fatty Acids, Unsaturated	178-205	C-C motif chemokine ligand 4	Rattus norvegicus	41-45
3101541-1	1986	High-performance liquid chromatography has been found to be an effective method for the determination of absolute configuration in the products of the lipoxygenase-catalyzed oxygenation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	189-216	linoleate 9S-lipoxygenase-4	Glycine max	151-163
3095627-9	1986	Although these specific oxidized fatty acids are unlikely to be ionophores, the ionophoretic properties of certain other oxygenated polyunsaturated fatty acids suggest a mechanism whereby accumulation of lipid oxidation products may be responsible for the altered membrane permeability we have observed after CCl4, and perhaps ultimately for cell death in CCl4-induced hepatic necrosis.	Fatty Acids, Unsaturated	132-159	C-C motif chemokine ligand 4	Rattus norvegicus	309-313
2438210-1	1987	Alpha-fetoprotein (AFP), an onco-fetal protein which binds specifically polyunsaturated fatty acids, has been shown to modulate arachidonic acid metabolism in a human T-cell line.	Fatty Acids, Unsaturated	72-99	alpha fetoprotein	Homo sapiens	0-17
2438210-1	1987	Alpha-fetoprotein (AFP), an onco-fetal protein which binds specifically polyunsaturated fatty acids, has been shown to modulate arachidonic acid metabolism in a human T-cell line.	Fatty Acids, Unsaturated	72-99	alpha fetoprotein	Homo sapiens	19-22
2975049-5	1987	The Ca-ATPase is a single polypeptide of Mr 138 kD, which is activated by calmodulin or, in its absence, by acidic phospholipids, polyunsaturated fatty acids, and limited proteolytic treatments.	Fatty Acids, Unsaturated	130-157	dynein axonemal heavy chain 8	Homo sapiens	7-13
3096987-4	1986	We have reported that unsaturated fatty acids (oleic acid and arachidonic acid) can activate protein kinase C independently of Ca2+ and phospholipid (Murakami, K., and Routtenberg, A.	Fatty Acids, Unsaturated	22-45	carbonic anhydrase 2	Homo sapiens	127-130
3768394-9	1986	All unsaturated fatty acids tested were potent inhibitors of phospholipase A2 activity (IC50 3-10 microM).	Fatty Acids, Unsaturated	4-27	phospholipase A2 group IB	Homo sapiens	61-77
3768394-11	1986	These in vitro data indicate that neutral-active and calcium-dependent phospholipase A2 in human polymorphonuclear leukocytes is largely suppressed by endogenous inhibitors and suggest that unsaturated fatty acids and some of their metabolites may partly account for this suppressor activity.	Fatty Acids, Unsaturated	190-213	phospholipase A2 group IB	Homo sapiens	71-87
3642201-4	1986	This imbalance is brought about by competitive inhibition of the enzyme delta-6-desaturase by unnatural trans and cis unsaturated fatty acids.	Fatty Acids, Unsaturated	118-141	fatty acid desaturase 2	Homo sapiens	72-90
3021238-5	1986	Incorporation of unsaturated fatty acids into macrophage phospholipids leads to an increase of O2- production as measured by lucigenin-dependent chemiluminescence and to an increased phospholipase A2 activity after challenge with phorbol ester or zymosan.	Fatty Acids, Unsaturated	17-40	phospholipase A2, group IB, pancreas	Mus musculus	183-199
2427529-6	1986	The cytoplasmic labeling, very low after an incubation in the presence of [3H-(20:4)]-AFP for 2 hours at 4 degrees C, increased rapidly after transfer of the cells for 5 minutes to 37 degrees C. These observations support the hypothesis that AFP plays a role in the intracellular delivery of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	292-319	alpha-fetoprotein	Rattus norvegicus	86-89
2428516-1	1986	Alpha-fetoprotein (AFP) is able to bind specifically polyunsaturated fatty acids, especially arachidonic acid, the major precursor for prostaglandin and leukotriene synthesis.	Fatty Acids, Unsaturated	53-80	alpha fetoprotein	Homo sapiens	0-17
2428516-1	1986	Alpha-fetoprotein (AFP) is able to bind specifically polyunsaturated fatty acids, especially arachidonic acid, the major precursor for prostaglandin and leukotriene synthesis.	Fatty Acids, Unsaturated	53-80	alpha fetoprotein	Homo sapiens	19-22
3719006-1	1986	Several polyunsaturated fatty acids (C18-C22 acids) have been compared in their uptake by human platelets and their acylation into glycerophospholipid subclasses.	Fatty Acids, Unsaturated	8-35	Bardet-Biedl syndrome 9	Homo sapiens	37-40
3086649-4	1986	It is proposed that the islet lipoxygenase directly peroxidizes unsaturated fatty acids esterified within membrane phospholipids, leading to changes in ion flux and enzyme activity (particularly phospholipase A2) at the membrane level.	Fatty Acids, Unsaturated	64-87	phospholipase A2 group IB	Homo sapiens	195-211
3002485-1	1986	This study has examined the thrombin-stimulated release of polyunsaturated fatty acids from endothelial glycerolipids.	Fatty Acids, Unsaturated	59-86	coagulation factor II, thrombin	Homo sapiens	28-36
3718540-9	1986	Hepatic epoxide hydratase activity was found to be positively correlated to the proportion of polyunsaturated fatty acids in the microsomal fractions of the liver.	Fatty Acids, Unsaturated	94-121	epoxide hydrolase 2	Rattus norvegicus	8-25
3707134-8	1986	All data together lead to the conclusion that the mitochondrial oxidation of highly polyunsaturated fatty acids is limited by the availability of NADPH and the activity of 2,4-dienoyl-CoA reductase which is induced by growth hormone treatment.	Fatty Acids, Unsaturated	84-111	gonadotropin releasing hormone receptor	Rattus norvegicus	218-232
3091009-4	1986	Contributory factors to the lower rates of lipid peroxidation observed include: a significant decrease in the polyunsaturated fatty acid content of Novikoff cells or Novikoff microsomes; the decreases are especially marked for the C20:4 and C22:6 fatty acids; a very marked reduction in NADPH-cytochrome c reductase; and no detectable content of cytochrome P-450.	Fatty Acids, Unsaturated	110-136	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	346-362
3485095-6	1986	Arrhenius plots of mIg capping were linear, with activation energies ranging from 14 to 23 kcal/mol depending on the saturated/unsaturated fatty acid ratio of B cell phospholipids.	Fatty Acids, Unsaturated	127-149	chemokine (C-X-C motif) ligand 9	Mus musculus	19-22
2417630-4	1986	The results confirm the binding specificity of alpha-fetoprotein for polyunsaturated fatty acids and also show that alpha-fetoprotein binds diethylstilbestrol much more strongly than albumin does.	Fatty Acids, Unsaturated	69-96	alpha fetoprotein	Homo sapiens	47-64
3002485-8	1986	Thus, the thrombin-stimulated release of polyunsaturated fatty acids from vascular endothelial cells is highly selective for arachidonate and eicosapentaenoate.	Fatty Acids, Unsaturated	41-68	coagulation factor II, thrombin	Homo sapiens	10-18
3012424-13	1986	In the premyelin fraction, polyunsaturated fatty acids were increased in shi and mld, but decreased in qk.	Fatty Acids, Unsaturated	27-54	myelin basic protein	Mus musculus	73-76
2883557-9	1986	The data are consistent with a release of unsaturated fatty acids by phospholipase A2 rendering the transport particles both leakier and the membranes less fluid than controls.	Fatty Acids, Unsaturated	42-65	phospholipase A2 group IB	Homo sapiens	69-85
2419923-1	1986	Previous work has shown that alpha-fetoprotein (AFP) is able to bind specifically polyunsaturated fatty acids, one of the major ligands being arachidonic acid (C20:4).	Fatty Acids, Unsaturated	82-109	alpha-fetoprotein	Rattus norvegicus	29-46
2419923-1	1986	Previous work has shown that alpha-fetoprotein (AFP) is able to bind specifically polyunsaturated fatty acids, one of the major ligands being arachidonic acid (C20:4).	Fatty Acids, Unsaturated	82-109	alpha-fetoprotein	Rattus norvegicus	48-51
25290781-1	1985	The leukotrienes are a group of biologically active molecules derived from the oxidative metabolism of unsaturated fatty acids via the 5-lipoxygenase pathway.	Fatty Acids, Unsaturated	103-126	arachidonate 5-lipoxygenase	Homo sapiens	135-149
4090406-2	1985	The level of very low density lipoproteins (VLDLP) grows, and suppression of lecithin-cholesteryl-acyltransferase (LCAT) activity is accompanied by reduction of the share of cholesterol derivatives with polyunsaturated fatty acids.	Fatty Acids, Unsaturated	203-230	lecithin-cholesterol acyltransferase	Homo sapiens	77-113
4090406-2	1985	The level of very low density lipoproteins (VLDLP) grows, and suppression of lecithin-cholesteryl-acyltransferase (LCAT) activity is accompanied by reduction of the share of cholesterol derivatives with polyunsaturated fatty acids.	Fatty Acids, Unsaturated	203-230	lecithin-cholesterol acyltransferase	Homo sapiens	115-119
3159012-3	1985	However, further investigation revealed, among other things, that polyunsaturated fatty acids (e.g., arachidonic acid) were as effective as Ca2+/phospholipid in promoting translational inhibition and phosphorylation of the alpha subunit of the chain-initiation factor eIF-2 and, moreover, HCI activation could be prevented or reversed in either case by NADPH-generating systems or by dithiols.	Fatty Acids, Unsaturated	66-93	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	268-273
2408770-2	1985	We have examined the effects of Ca2+ ionophore and long-chain unsaturated fatty acids on the translocation of Ca2+ across the liposomal membrane by using Quin II-entrapped liposomes, a sensitive assay system for ionophoresis of Ca2+.	Fatty Acids, Unsaturated	62-85	carbonic anhydrase 2	Homo sapiens	110-113
2408770-2	1985	We have examined the effects of Ca2+ ionophore and long-chain unsaturated fatty acids on the translocation of Ca2+ across the liposomal membrane by using Quin II-entrapped liposomes, a sensitive assay system for ionophoresis of Ca2+.	Fatty Acids, Unsaturated	62-85	carbonic anhydrase 2	Homo sapiens	110-113
2418133-8	1985	This time-dependent development of IFN inducibility was abrogated almost completely when "aging" was carried out in the presence of drugs that inhibited the synthesis of cyclic derivatives of C20 oxygenated unsaturated fatty acids, i.e., inhibitors of prostaglandin/leukotriene synthesis and the arachidonic acid cascade.	Fatty Acids, Unsaturated	207-230	interferon	Gallus gallus	35-38
3925796-4	1985	In the present study we demonstrate that endothelium-dependent relaxation of rabbit aorta was induced by melittin, a polypeptide toxin that activates phospholipase A2 to liberate polyunsaturated fatty acids (especially arachidonic acid) from membrane phospholipids.	Fatty Acids, Unsaturated	179-206	phospholipase A2	Oryctolagus cuniculus	150-166
3997883-4	1985	The major oxygenated polyunsaturated fatty acid metabolite formed by rat and bovine blood vessels was 6-oxo-PGF1 alpha.	Fatty Acids, Unsaturated	21-47	prostaglandin F synthase 2	Bos taurus	108-112
4067666-6	1985	Unsaturated fatty acids, however, were shown to be suppressive and polyunsaturated fatty acid such as linoleic and linolenic acids more effective than oleic acid in suppressing liver ACMSD activity.	Fatty Acids, Unsaturated	67-93	aminocarboxymuconate semialdehyde decarboxylase	Rattus norvegicus	183-188
4067666-7	1985	These suppressive effects of dietary unsaturated fatty acids on the liver ACMSD activity were not considered to be caused by their direct effect on the enzyme protein.	Fatty Acids, Unsaturated	37-60	aminocarboxymuconate semialdehyde decarboxylase	Rattus norvegicus	74-79
2580485-5	1985	AFP has high affinity to unsaturated fatty acids (UFA) such as arachidonic acid (C20:4) and so on.	Fatty Acids, Unsaturated	25-48	alpha-fetoprotein	Rattus norvegicus	0-3
2988221-2	1985	The formation of these compounds takes place from poly-unsaturated fatty acids and is regulated: here the phospholipase A2 plays a role.	Fatty Acids, Unsaturated	50-78	phospholipase A2 group IB	Homo sapiens	106-122
3986373-4	1985	It has been shown in model experiments with incorporation into the tumor cell membrane of brain ganglioside GD3 combined with thymic LacCer or with egg phosphatidylcholine that the increase in the sensitivity of the tumor cell membrane to spleen effectors is linked with a change in the properties of the lipid membrane matrix under the effect of unsaturated fatty acids (e.g. in experiments with phosphatidylcholine).	Fatty Acids, Unsaturated	347-370	GRDX	Homo sapiens	108-111
3918577-4	1985	Polyunsaturated fatty acid derivatives, prepared by incubation with lipoxygenase (linoleate: oxygen oxidoreductase; EC 1.13.11.12) or by autoxidation in air, showed a markedly increased potency over the parent compounds.	Fatty Acids, Unsaturated	0-26	thioredoxin reductase 1	Homo sapiens	100-114
2580485-5	1985	AFP has high affinity to unsaturated fatty acids (UFA) such as arachidonic acid (C20:4) and so on.	Fatty Acids, Unsaturated	50-53	alpha-fetoprotein	Rattus norvegicus	0-3
3918999-5	1985	Apo-A-I was a more potent activator than apo-A-IV with egg yolk lecithin, L-alpha-dioleoylphosphatidylcholine, and L-alpha-phosphatidylcholine substituted with one saturated and one unsaturated fatty acid regardless of the substitution position.	Fatty Acids, Unsaturated	182-204	apolipoprotein A1	Homo sapiens	0-7
3918999-5	1985	Apo-A-I was a more potent activator than apo-A-IV with egg yolk lecithin, L-alpha-dioleoylphosphatidylcholine, and L-alpha-phosphatidylcholine substituted with one saturated and one unsaturated fatty acid regardless of the substitution position.	Fatty Acids, Unsaturated	182-204	apolipoprotein A4	Homo sapiens	41-49
3975871-1	1985	A study was made of the inhibition of antithrombin III (At III) activity by lipid peroxides prepared from autoxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	122-145	serpin family C member 1	Homo sapiens	38-54
3975871-1	1985	A study was made of the inhibition of antithrombin III (At III) activity by lipid peroxides prepared from autoxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	122-145	serpin family C member 1	Homo sapiens	56-62
3157775-0	1985	Does an increase in membrane unsaturated fatty acids account for Tween 80 stimulation of glucosyltransferase secretion by Streptococcus salivarius?	Fatty Acids, Unsaturated	29-52	SSAL8618_RS07090	Streptococcus salivarius	89-108
3157775-3	1985	The possibility that an increase in membrane unsaturated fatty acids promoted extracellular glucosyltransferase production was examined by growing cells at different temperatures in the presence or absence of Tween 80.	Fatty Acids, Unsaturated	45-68	SSAL8618_RS07090	Streptococcus salivarius	92-111
3939140-3	1985	To understand fully the interaction between reactive oxygen metabolites, myoglobin and lipid, we investigate the possibility that myoglobin may use xanthine oxidase-generated superoxide and/or hydrogen peroxide to catalyze peroxidation of a polyunsaturated fatty acid.	Fatty Acids, Unsaturated	241-267	myoglobin	Homo sapiens	130-139
6390059-8	1984	Since microsomal 1-acyl-GPAT and GPCAT are known to have higher activity toward unsaturated fatty acyl-CoA donors, the increased GPCAT activity coupled with the decreased lysophospholipase activity and the increased 1-acyl-GPAT activity in diabetes would tend to increase the formation of newly synthesized phospholipids containing unsaturated fatty acids.	Fatty Acids, Unsaturated	332-355	glycerol-3-phosphate acyltransferase, mitochondrial	Rattus norvegicus	24-28
3855556-0	1985	Inhibition of human platelet phospholipase A2 activity by unsaturated fatty acids.	Fatty Acids, Unsaturated	58-81	phospholipase A2 group IB	Homo sapiens	29-45
3855556-7	1985	Inhibition of PLA2 by unsaturated fatty acids appeared to be noncompetitive.	Fatty Acids, Unsaturated	22-45	phospholipase A2 group IB	Homo sapiens	14-18
3855556-8	1985	PLA2 absolutely required Ca2+ for activity; the inhibition by unsaturated fatty acids was not reversed by Ca2+.	Fatty Acids, Unsaturated	62-85	phospholipase A2 group IB	Homo sapiens	0-4
3855556-9	1985	The finding that unsaturated fatty acids are potent inhibitors of PLA2 would explain its generally low activity in human platelet extracts and its marked increase of activity during the course of enzyme purification.	Fatty Acids, Unsaturated	17-40	phospholipase A2 group IB	Homo sapiens	66-70
6529855-2	1984	Improvement of diabetic control, achieved by treatment with continuous subcutaneous insulin infusion coincided with an increase of arachidonic acid and a normalization of total polyunsaturated fatty acids, with a concomitant decrease of total saturated fatty acids and total monounsaturated fatty acids, especially 18:1c, omega 9.	Fatty Acids, Unsaturated	177-204	insulin	Homo sapiens	84-91
6488154-0	1984	In vivo stimulation of DNA synthesis and induction of ornithine decarboxylase in rat colon by fatty acid hydroperoxides, autoxidation products of unsaturated fatty acids.	Fatty Acids, Unsaturated	146-169	ornithine decarboxylase 1	Rattus norvegicus	54-77
6497946-11	1984	The major phospholipids in plasma are identical in both groups and there is an identical change under the PUFA diet, sphingomyelin is increased and phosphatidylcholine is decreased, which may be related to an increase of the HDL2/HDL3 ratio.	Fatty Acids, Unsaturated	106-110	junctophilin 3	Homo sapiens	225-229
6497946-11	1984	The major phospholipids in plasma are identical in both groups and there is an identical change under the PUFA diet, sphingomyelin is increased and phosphatidylcholine is decreased, which may be related to an increase of the HDL2/HDL3 ratio.	Fatty Acids, Unsaturated	106-110	HDL3	Homo sapiens	230-234
6585201-4	1984	Phospholipase A2 enhanced the release only of unsaturated fatty acids, whereas phospholipase C stimulated the release of individual free fatty acids (C 16:0, C 18:0, C 18:1, C 18:2 and C 20:4).	Fatty Acids, Unsaturated	46-69	phospholipase A2	Oryctolagus cuniculus	0-16
6470514-6	1984	This and other features of the composition of the unsaturated fatty acids indicate that the delta 6-desaturase that produces the monounsaturated fatty acids of human sebum requires a substrate having a straight chain of at least 12 carbon atoms extending from the carboxyl group.	Fatty Acids, Unsaturated	50-73	fatty acid desaturase 2	Homo sapiens	92-110
6397528-0	1984	An inhibitory effect of dietary polyunsaturated fatty acids on renin secretion in the isolated perfused rat kidney.	Fatty Acids, Unsaturated	32-59	renin	Rattus norvegicus	63-68
6397528-1	1984	The influence of dietary modification of polyunsaturated fatty acids (PUFA) on renin secretion, renal vascular tone and prostanoid excretion was studied in isolated perfused rat kidneys under basal conditions and in response to angiotensin II.	Fatty Acids, Unsaturated	70-74	renin	Rattus norvegicus	79-84
6201166-1	1984	Human alpha-fetoprotein (HAFP) has three binding sites for polyunsaturated fatty acids with association constant Ka = 1.8 X 10(7) M-1.	Fatty Acids, Unsaturated	59-86	alpha fetoprotein	Homo sapiens	6-23
6204605-4	1983	These results contribute to explain, to some extent, the important catabolism of polyunsaturated fatty acids in the diabetic rat, as they may reveal an increased activity of phospholipase A2 in this kind of animal.	Fatty Acids, Unsaturated	81-108	phospholipase A2 group IB	Rattus norvegicus	174-190
6525977-1	1984	The kinetics of cytochrome P-450 content in endoplasmic reticulum membranes at different stages of hepatocarcinogenesis was studied under the influence of unsaturated fatty acids by the EPR method.	Fatty Acids, Unsaturated	155-178	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	16-32
6525977-3	1984	The diet containing unsaturated fatty acids has a stabilizing effect revealed by the similar changes in the content of cytochrome P-450, phosphatidyl choline and fatty acids composition and also in the level of organization of the endoplasmic reticulum membrane lipid bilayer.	Fatty Acids, Unsaturated	20-43	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	119-135
6506461-3	1984	It was found that with the increase in the bacterial protein content of the feed mixtures there was a rising trend in the sum total of the unsaturated fatty acids (C16:1, C18:1, C18:2) and a lowering one of the saturated fatty acids (C14, C16, C18) as against their content in the meat of the control group.	Fatty Acids, Unsaturated	139-162	galectin 1B	Gallus gallus	164-167
6197732-3	1983	Rat AFP was shown to possess one high affinity binding site and several (12-13) low affinity sites while human AFP presented three equivalent binding sites for polyunsaturated fatty acids.	Fatty Acids, Unsaturated	160-187	alpha fetoprotein	Homo sapiens	111-114
6661463-5	1983	It was assumed that unsaturated fatty acids may prevent the interaction of adenylate cyclase with calmodulin.	Fatty Acids, Unsaturated	20-43	calmodulin 1	Homo sapiens	98-108
6874684-7	1983	It is concluded that the bile salt-activated lipase may possess a special potential for a rapid release of short chain and polyunsaturated fatty acids from dietary triacylglycerols in the intestinal lumen of infants.	Fatty Acids, Unsaturated	123-150	carboxyl ester lipase	Homo sapiens	25-51
6833274-0	1983	A study of the reactivity of HO2/O2- with unsaturated fatty acids.	Fatty Acids, Unsaturated	42-65	heme oxygenase 2	Homo sapiens	29-32
6193343-1	1983	Thin layer chromatography with four different solvent systems enabled us to show that ovarian extracts contained nonesterified unsaturated fatty acids able to compete with estradiol on the alpha-fetoprotein binding site.	Fatty Acids, Unsaturated	127-150	alpha-fetoprotein	Rattus norvegicus	189-206
6314064-7	1983	The results of these experiments suggest that the increase in Km in sarcolemma 5"-nucleotidase could be due to the reduction of the sarcolemmal polyunsaturated fatty acid concentration, the only lipid alteration observed.	Fatty Acids, Unsaturated	144-170	5' nucleotidase, ecto	Rattus norvegicus	79-94
6833274-3	1983	While kinetic results suggest that the HO2 radical reacts with the double allylic H atom of the polyunsaturated fatty acids, thermodynamic approximations indicate that the reaction is exothermic by approximately 10 kcal/mol.	Fatty Acids, Unsaturated	96-123	heme oxygenase 2	Homo sapiens	39-42
6200043-0	1983	Some biological roles for alpha-fetoprotein-unsaturated fatty acid complexes.	Fatty Acids, Unsaturated	44-66	alpha fetoprotein	Homo sapiens	26-43
6823207-1	1983	Liver microsomal concentration of cytochrome P.450 is increased in animals which are fed diets rich in polyunsaturated fatty acids.	Fatty Acids, Unsaturated	103-130	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	34-50
6751393-4	1982	Insulin receptors were present in the normal cells at 180,000 sites/cell but this fell to 125000 (P less than 0.001) in cells enriched in monounsaturated fatty acids and rose to 386,000 (P less than 0.001) in cells enriched in polyunsaturated fatty acids.	Fatty Acids, Unsaturated	227-254	insulin	Homo sapiens	0-7
7126629-1	1982	Since the peroxidative cleavage of unsaturated fatty acids can result in either the release of carbonyl compounds or the formation of carbonyl functions in the acyl residues, evidence for the presence of carbonyl groups in liver microsomal phospholipids was searched for in in vivo conditions (CCl4 and BrCCl3 intoxications) in which peroxidation of lipids of hepatic endoplasmic reticulum had been previously demonstrated.	Fatty Acids, Unsaturated	35-58	C-C motif chemokine ligand 4	Rattus norvegicus	294-298
6835034-3	1983	A rapid increase in C-9 fatty acid desaturase activity seen at the approximate time of weaning may be related to a decrease in the polyunsaturated fatty acid (PUFA) content of the diet as the rat begins to consume laboratory chow instead of mother"s milk.	Fatty Acids, Unsaturated	131-157	complement C9	Rattus norvegicus	20-23
6835034-3	1983	A rapid increase in C-9 fatty acid desaturase activity seen at the approximate time of weaning may be related to a decrease in the polyunsaturated fatty acid (PUFA) content of the diet as the rat begins to consume laboratory chow instead of mother"s milk.	Fatty Acids, Unsaturated	159-163	complement C9	Rattus norvegicus	20-23
6299272-1	1982	Acidic phospholipids, unsaturated fatty acids and limited proteolysis mimic the activating effect of calmodulin on erythrocyte Ca2+-transport ATPase and on brain cyclic nucleotide phosphodiesterase, as has been reported previously in several studies.	Fatty Acids, Unsaturated	22-45	calmodulin 1	Homo sapiens	101-111
6952288-4	1982	With intact platelet preparations it was found that (i) all unsaturated fatty acids enhanced the biosynthesis of TxB2, PGE2, PGD2 and PGF2 alpha, (ii) unsaturated fatty acids reduced the formation of HHT and HETE with the exception of oleic acid which showed very little effect, (iii) unsaturated fatty acids reduced the formation of MDA, whereas palmitic and stearic acids increased its formation and (iv) all unsaturated fatty acids reduced the synthesis of prostaglandin endoperoxides.	Fatty Acids, Unsaturated	60-83	prostaglandin D2 synthase	Homo sapiens	125-129
6281246-1	1982	CDP-diglyceride : inositol transferase was inhibited by unsaturated fatty acids.	Fatty Acids, Unsaturated	56-79	cut-like homeobox 1	Rattus norvegicus	0-3
7061456-8	1982	In particular, the ratio of released saturated to unsaturated fatty acids was significantly higher with the acidic enzyme as compared with the basic phospholipase A2.	Fatty Acids, Unsaturated	50-73	phospholipase A2 group IB	Homo sapiens	149-165
6952288-4	1982	With intact platelet preparations it was found that (i) all unsaturated fatty acids enhanced the biosynthesis of TxB2, PGE2, PGD2 and PGF2 alpha, (ii) unsaturated fatty acids reduced the formation of HHT and HETE with the exception of oleic acid which showed very little effect, (iii) unsaturated fatty acids reduced the formation of MDA, whereas palmitic and stearic acids increased its formation and (iv) all unsaturated fatty acids reduced the synthesis of prostaglandin endoperoxides.	Fatty Acids, Unsaturated	151-174	prostaglandin D2 synthase	Homo sapiens	125-129
6952288-4	1982	With intact platelet preparations it was found that (i) all unsaturated fatty acids enhanced the biosynthesis of TxB2, PGE2, PGD2 and PGF2 alpha, (ii) unsaturated fatty acids reduced the formation of HHT and HETE with the exception of oleic acid which showed very little effect, (iii) unsaturated fatty acids reduced the formation of MDA, whereas palmitic and stearic acids increased its formation and (iv) all unsaturated fatty acids reduced the synthesis of prostaglandin endoperoxides.	Fatty Acids, Unsaturated	151-174	prostaglandin D2 synthase	Homo sapiens	125-129
6952288-4	1982	With intact platelet preparations it was found that (i) all unsaturated fatty acids enhanced the biosynthesis of TxB2, PGE2, PGD2 and PGF2 alpha, (ii) unsaturated fatty acids reduced the formation of HHT and HETE with the exception of oleic acid which showed very little effect, (iii) unsaturated fatty acids reduced the formation of MDA, whereas palmitic and stearic acids increased its formation and (iv) all unsaturated fatty acids reduced the synthesis of prostaglandin endoperoxides.	Fatty Acids, Unsaturated	151-174	prostaglandin D2 synthase	Homo sapiens	125-129
6801662-6	1982	THe isolation of these isomeric HETEs suggests that cytochrome P-450 may play a role in the oxidative metabolism of arachidonic acid to physiologically and pharmacologically important hydroxylated unsaturated fatty acids.	Fatty Acids, Unsaturated	197-220	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	52-68
7036731-2	1982	Synthesis of these unsaturated fatty acids from arachidonate precursors is closely regulated by intrarenal factors, and circulating angiotensin II, catecholamines, arginine vasopressin and bradykinin.	Fatty Acids, Unsaturated	19-42	angiotensinogen	Homo sapiens	132-146
7036731-2	1982	Synthesis of these unsaturated fatty acids from arachidonate precursors is closely regulated by intrarenal factors, and circulating angiotensin II, catecholamines, arginine vasopressin and bradykinin.	Fatty Acids, Unsaturated	19-42	arginine vasopressin	Homo sapiens	173-184
7036731-2	1982	Synthesis of these unsaturated fatty acids from arachidonate precursors is closely regulated by intrarenal factors, and circulating angiotensin II, catecholamines, arginine vasopressin and bradykinin.	Fatty Acids, Unsaturated	19-42	kininogen 1	Homo sapiens	189-199
6461644-3	1982	Diacylglycerols containing at least one unsaturated fatty acid at either position 1 or 2 are fully active in this capacity, irrespective of the chain length of the other fatty acyl moiety in the range tested, C2 to C18.	Fatty Acids, Unsaturated	40-62	Bardet-Biedl syndrome 9	Homo sapiens	215-218
6178072-8	1982	Attention is brought to the binding and transport of polyunsaturated fatty acids by AFP and albumin as a possible explanation for the transitory presence of these proteins in the developing nervous system.	Fatty Acids, Unsaturated	53-80	alpha-fetoprotein	Papio anubis	84-87
6779154-1	1980	The Effect of Various Alimentary Fats, Especially "Diet" Fats With High Proportions of Polyene Acids on the Blood Count, Cholesterol Levels and Organ Systems: This paper describes our observations on the possible toxicity of highly unsaturated fatty acids on the cell systems of the red blood, the liver and kidney.	Fatty Acids, Unsaturated	232-255	chromosome 10 open reading frame 90	Homo sapiens	33-37
7055601-2	1982	The induction of ATP-citrate lyase activity in mouse liver dietary carbohydrate (glucose) in markedly reduced by including in the diet a source of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	147-174	ATP citrate lyase	Mus musculus	17-34
7055601-6	1982	Elevated levels of enzyme activity in the hydrogenated cottonseed oil-fed livers were not accompanied by a similar increase in the amount of enzyme protein., To explain such findings, we propose that the activity of hepatic ATP-citrate lyase is regulated by dietary polyunsaturated fatty acids through a mechanism involving the conversion of a catalytically active form of the enzyme to a catalytically inactive form.	Fatty Acids, Unsaturated	266-293	ATP citrate lyase	Mus musculus	224-241
7035304-3	1982	LYN did not alter the IVGTT or plasma insulin but decreased the proportion of polyunsaturated fatty acids (PUFA) in serum lecithin (p less than 0.01) and cholesterol esters (p less than 0.01) where oleic acid was reciprocally increased (p less than 0.05).	Fatty Acids, Unsaturated	78-105	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
7035304-3	1982	LYN did not alter the IVGTT or plasma insulin but decreased the proportion of polyunsaturated fatty acids (PUFA) in serum lecithin (p less than 0.01) and cholesterol esters (p less than 0.01) where oleic acid was reciprocally increased (p less than 0.05).	Fatty Acids, Unsaturated	107-111	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
7035304-7	1982	EE + LYN also increased (p less than 0.05) lecithin palmitate and decreased stearate (p less than 0.05) and had a concomitant tendency to lower PUFA and increase oleic acid in both lecithin and cholesterol esters.	Fatty Acids, Unsaturated	144-148	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-8
6101134-1	1982	Relatively high proportions of long-chain, polyunsaturated fatty acids seem to be required in rod photoreceptor membranes in order to provide the precise microenvironment for the proper function of the visual pigment rhodopsin.	Fatty Acids, Unsaturated	43-70	rhodopsin	Homo sapiens	217-226
7213781-9	1981	The phospholipase A2 exhibits a degree of specificity for substrate lipids containing polyunsaturated fatty acid residues which can serve as precursors for prostaglandin formation.	Fatty Acids, Unsaturated	86-112	phospholipase A2, group IB, pancreas	Mus musculus	4-20
7134791-4	1982	The high antithrombin III level in the Eskimos may at least partly be a consequence of a high dietary intake of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	112-139	serpin family C member 1	Homo sapiens	9-25
6126596-1	1982	The artificial insertion of increasing amounts of unsaturated fatty acids into human erythrocyte membranes modulated ATPase activities in a biphasic manner, depending on the number and position of double bonds, their configuration, and the chain length.	Fatty Acids, Unsaturated	50-73	dynein axonemal heavy chain 8	Homo sapiens	117-123
6126596-9	1982	Unsaturated fatty acids simulated the effects of calmodulin on Ca2+-ATPase of native erythrocyte membranes (i.e., increase of Vmax from 1.6 to 5 mumol PO43- .	Fatty Acids, Unsaturated	0-23	dynein axonemal heavy chain 8	Homo sapiens	68-74
7195802-0	1981	Dietary vitamin E and polyunsaturated fatty acid (PUFA) in newborn babies with physiological jaundice.	Fatty Acids, Unsaturated	50-54	PUFA	Bos taurus	22-48
6783456-0	1981	Electrophoretically homogeneous cytochrome P-450: influence of a series of unsaturated fatty acids on the reconstituted hydroxylase activity.	Fatty Acids, Unsaturated	75-98	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	32-48
7342823-6	1981	The omega 3 polyunsaturated fatty acids are known to be inhibitors of the synthesis of PgF2 alpha which is involved in ovulation and luteolysis.	Fatty Acids, Unsaturated	12-39	prostaglandin F synthase 2	Bos taurus	87-91
6779154-1	1980	The Effect of Various Alimentary Fats, Especially "Diet" Fats With High Proportions of Polyene Acids on the Blood Count, Cholesterol Levels and Organ Systems: This paper describes our observations on the possible toxicity of highly unsaturated fatty acids on the cell systems of the red blood, the liver and kidney.	Fatty Acids, Unsaturated	232-255	chromosome 10 open reading frame 90	Homo sapiens	57-61
6779154-5	1980	Further, it could be shown that highly unsaturated fatty acids (polyene acids) of the C189:2 cis ("curved fats") type such as occur in diet margarines, thistle oil and other vegetable oils in high concentrations, can cause damage to cell membranes and the cell systems of the red blood, the liver and kidney by excessive ingestion in the food.	Fatty Acids, Unsaturated	39-62	chromosome 10 open reading frame 90	Homo sapiens	106-110
6169054-0	1980	High affinity of nonesterified polyunsaturated fatty acids for rat alpha-fetoprotein (AFP).	Fatty Acids, Unsaturated	31-58	alpha-fetoprotein	Rattus norvegicus	67-84
6169054-0	1980	High affinity of nonesterified polyunsaturated fatty acids for rat alpha-fetoprotein (AFP).	Fatty Acids, Unsaturated	31-58	alpha-fetoprotein	Rattus norvegicus	86-89
543508-2	1979	Iron-supplemented, "tocopherol-sufficient," low-birth-weight premature infants fed (selenium-poor) formulas rich in polyunsaturated fatty acid (greater than 35% of fat as PUFA) develop severe hemolysis secondary to erythrocyte phosphatidyl ethanolamine loss.	Fatty Acids, Unsaturated	116-142	pumilio RNA binding family member 3	Homo sapiens	171-175
6251349-3	1980	Unsaturated fatty acids markedly enhanced the reduction of ferric cytochrome c by ferrous iron.	Fatty Acids, Unsaturated	0-23	cytochrome c, somatic	Homo sapiens	66-78
95001-7	1979	These results suggest that AFP and SA play an important role in the transport and the incorporation of polyunsaturated fatty acids in the developing brain.	Fatty Acids, Unsaturated	103-130	alpha-fetoprotein	Rattus norvegicus	27-30
6154708-8	1980	We propose that the function of this anionic ligand binding site on AFP is for the transport of bilirubin and polyunsaturated fatty acids in fetal serum, as well as for the cross-placental transfer of this metabolite and of essential fatty acids.	Fatty Acids, Unsaturated	110-137	alpha fetoprotein	Bos taurus	68-71
288052-5	1979	These findings suggested the activation by chemoattractants of phospholipase A2, an enzyme that removes an unsaturated fatty acid from phospholipids.	Fatty Acids, Unsaturated	107-129	phospholipase A2	Oryctolagus cuniculus	63-79
753289-0	1978	[Effect of unsaturated fatty acids on basal plasma renin activity and after postural stimulation].	Fatty Acids, Unsaturated	11-34	renin	Homo sapiens	51-56
583227-0	1979	Effects of unsaturated fatty acids in phospholipids on the in vitro activation of the lipoprotein lipase and the triglyceride lipase.	Fatty Acids, Unsaturated	11-34	lipoprotein lipase	Homo sapiens	86-104
318410-2	1979	The cholesterol esterifying activity in mouse plasma has been identified as lecithin:cholesterol acyltransferase (LCAT) on the basis of stoichiometric data, predominant transfer of polyunsaturated fatty acids, wide pH optimum and inhibition of esterification by phospholipase A2 and sulphydryl blocking agents.	Fatty Acids, Unsaturated	181-208	lecithin cholesterol acyltransferase	Mus musculus	76-112
318410-2	1979	The cholesterol esterifying activity in mouse plasma has been identified as lecithin:cholesterol acyltransferase (LCAT) on the basis of stoichiometric data, predominant transfer of polyunsaturated fatty acids, wide pH optimum and inhibition of esterification by phospholipase A2 and sulphydryl blocking agents.	Fatty Acids, Unsaturated	181-208	lecithin cholesterol acyltransferase	Mus musculus	114-118
345274-1	1978	Several fluorinated fatty acids of the general structure CH3(CH2)13--mCF2(CH2)m--2COOH are incorporated biosynthetically as unsaturated fatty acid analogues into the phospholipids of Escherichia coli.	Fatty Acids, Unsaturated	124-146	coagulation factor II	Mus musculus	69-73
208191-0	1978	Effect of unsaturated fatty acids on separated form of human platelet cyclic nucleotide phosphodiesterase.	Fatty Acids, Unsaturated	10-33	phosphodiesterase 3B	Homo sapiens	70-105
197573-2	1977	The existence of marked differences in the degradation rate for each phospholipid suggests a relationship between the alteration of phosphatidylcholine containing one saturated and one unsaturated fatty acid and the decrease in activity of glucose-6-phosphatase; the inactivation of this enzyme was unrelated to the alteration of other phospholipids.	Fatty Acids, Unsaturated	185-207	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	240-261
389585-9	1978	Highly reactive electrophilic radicals (e.g. CCl3) can initiate lipid peroxidation in biomembranes and this is associated with changes in polyunsaturated fatty acids and in membrane fluidity.	Fatty Acids, Unsaturated	138-165	C-C motif chemokine ligand 3	Homo sapiens	45-49
685583-0	1978	[Combined effect of peroxidated unsaturated fatty acids and vitamin E on the activity of rat liver tryptophan pyrrolase].	Fatty Acids, Unsaturated	32-55	tryptophan 2,3-dioxygenase	Rattus norvegicus	99-119
197573-3	1977	These results support the idea that glucose-6-phosphatase and molecules of phosphatidylcholine having one saturated and one unsaturated fatty acid are in close apposition within the microsomal membrane.	Fatty Acids, Unsaturated	124-146	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	36-57
18647-7	1977	From the data presented, the magnitude of the controlling effect of polyunsaturated fatty acids on fatty acid synthetase and stearoyl-CoA desaturase activity is determined and its relevance to lipogenesis in man based on daily intake of carbohydrate and linoleic acid is discussed.	Fatty Acids, Unsaturated	68-95	stearoyl-CoA desaturase	Homo sapiens	125-148
191010-0	1977	Photosensitization by hematoporphyrin: ESP evidence for free radical induction in unsaturated fatty acids and for singlet oxygen production.	Fatty Acids, Unsaturated	82-105	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	39-42
416939-2	1977	The mechanism by which this procedure provokes abortion may be through the release of lysosomal phospholipase A2 (EC 3.1.1.4), an enzyme thought to regulate the formation of polyunsaturated fatty acids utilized for prostaglandin synthesis.	Fatty Acids, Unsaturated	174-201	phospholipase A2 group XV	Homo sapiens	86-112
822867-0	1976	Steady-state kinetics of lipoxygenase oxygenation of unsaturated fatty acids.	Fatty Acids, Unsaturated	53-76	linoleate 9S-lipoxygenase-4	Glycine max	25-37
9149-10	1976	Furthermore, these observations suggest a role for unsaturated fatty acids in the control of intracellular cyclic GMP levels.	Fatty Acids, Unsaturated	51-74	5'-nucleotidase, cytosolic II	Homo sapiens	114-117
776622-10	1976	Treatment of the diglyceride with pancreatic lipase showed CDP-diglyceride with the asymmetric distribution of fatty acids characteristic of most mammalian phospholipids, saturated fatty acids being found mostly at position 1 and polyunsaturated fatty acids at position 2.	Fatty Acids, Unsaturated	230-257	cut like homeobox 1	Homo sapiens	59-62
1270652-8	1976	Oleic acid and total unsaturated fatty acids were lowest in milk fat from cows fed hay while palmitic acid was highest from cows fed hay and haylage.	Fatty Acids, Unsaturated	21-44	Weaning weight-maternal milk	Bos taurus	60-64
1155030-0	1975	Inhibitory effect of unsaturated fatty acids on lymphocyte-antigen interaction with special reference to multiple sclerosis.	Fatty Acids, Unsaturated	21-44	major histocompatibility complex, class II, DO alpha	Homo sapiens	48-66
766924-3	1975	The Saccharomyces cerevisiae mutant KD46 (ole 2), which is unable to synthesize unsaturated fatty acids, was grown on limiting amounts of different added unsaturated fatty acids.	Fatty Acids, Unsaturated	154-177	hydroxymethylbilane synthase	Saccharomyces cerevisiae S288C	42-47
240188-2	1975	Phospholipase A2, an enzyme which may regulate the formation of polyunsaturated fatty acids utilized for prostaglandin synthesis, was found to have significant higher activity in decidual than in myometrial tissue.	Fatty Acids, Unsaturated	64-91	phospholipase A2 group IB	Homo sapiens	0-16
4659256-0	1972	The effect of unsaturated fatty acids on the rate of synthesis of rat liver glucose-6-phosphate dehydrogenase.	Fatty Acids, Unsaturated	14-37	glucose-6-phosphate dehydrogenase	Rattus norvegicus	76-109
1116880-0	1975	Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA and PPD.	Fatty Acids, Unsaturated	30-57	lamin B receptor	Homo sapiens	98-101
1116880-1	1975	Both saturated (SFA) and unsaturated fatty acids (UFS) inhibited PHA- and PPD-induced lymphocyte transformation.	Fatty Acids, Unsaturated	25-48	lamin B receptor	Homo sapiens	65-68
1116880-2	1975	The degree of inhibition varied with the nature of the fatty acid (FA) and further comparison with their effect on unstimulated lymphocyte cultures suggests a specific action of polyunsaturated fatty acid (PUFA) on the lymphocyte PHA- and -PPD interaction.	Fatty Acids, Unsaturated	178-204	lamin B receptor	Homo sapiens	230-233
1116880-2	1975	The degree of inhibition varied with the nature of the fatty acid (FA) and further comparison with their effect on unstimulated lymphocyte cultures suggests a specific action of polyunsaturated fatty acid (PUFA) on the lymphocyte PHA- and -PPD interaction.	Fatty Acids, Unsaturated	206-210	lamin B receptor	Homo sapiens	230-233
4456929-0	1974	[Joint effect of insulin, hydrocortisone and peroxidized unsaturated fatty acids on urokinase and histidase activity].	Fatty Acids, Unsaturated	57-80	histidine ammonia-lyase	Homo sapiens	98-107
4572732-0	1973	Synthesis of unsaturated fatty acids and the lesion in fab B mutants.	Fatty Acids, Unsaturated	13-36	FA complementation group B	Homo sapiens	55-58
1199556-0	1975	[Effect of unsaturated fatty acids on the activity of transketolase and transaldolase in rat liver].	Fatty Acids, Unsaturated	11-34	transketolase	Rattus norvegicus	54-67
1199556-0	1975	[Effect of unsaturated fatty acids on the activity of transketolase and transaldolase in rat liver].	Fatty Acids, Unsaturated	11-34	transaldolase 1	Rattus norvegicus	72-85
34059134-8	2021	CSCs had decreased levels of major classes of neutral lipids compared to non-CSCs, but had significantly increased polyunsaturated fatty acid production due to high fatty acid desaturase (FADS1/2) expression which was essential to maintain CSC viability and self-renewal.	Fatty Acids, Unsaturated	115-141	stearoyl-CoA desaturase	Homo sapiens	165-186
13951587-0	1962	The site of action of phosphatide acyl-hydrolase (phospholipase A) on mixed-acid phosphatides containing a poly-unsaturated fatty acid.	Fatty Acids, Unsaturated	107-134	phospholipase A and acyltransferase 1	Homo sapiens	50-65
13492085-0	1957	Effect of fat in diet on unsaturated fatty acids in phospholipid, cholesterol ester and glyceride fractions in serum of dogs.	Fatty Acids, Unsaturated	25-48	FAT atypical cadherin 1	Canis lupus familiaris	10-13
13319128-0	1956	A note on the effect of vitamin B12 on the unsaturated fatty acid content of castor oil.	Fatty Acids, Unsaturated	43-65	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	32-35
33604770-7	2021	The authors previously reported that FABP3, which preferentially binds to n-6 PUFAs, is strongly expressed in the gamma-aminobutyric acid (GABAergic) inhibitory interneurons of the adult mouse anterior cingulate cortex (ACC), which is a component of the limbic cortex and is important for the coordination of cognitive and emotional behaviors.	Fatty Acids, Unsaturated	78-83	fatty acid binding protein 3, muscle and heart	Mus musculus	37-42
33737181-1	2021	Fatty acid desaturase catalyzes the desaturation reactions by insertion of double bonds into the fatty acyl chain, producing unsaturated fatty acids.	Fatty Acids, Unsaturated	125-148	omega-6 fatty acid desaturase, endoplasmic reticulum	Brassica napus	0-21
5700018-7	1968	It is postulated that serum albumin affects chloroplast photoreactions by binding endogenously released unsaturated fatty acids.	Fatty Acids, Unsaturated	104-127	albumin	Homo sapiens	22-35
34059134-8	2021	CSCs had decreased levels of major classes of neutral lipids compared to non-CSCs, but had significantly increased polyunsaturated fatty acid production due to high fatty acid desaturase (FADS1/2) expression which was essential to maintain CSC viability and self-renewal.	Fatty Acids, Unsaturated	115-141	fatty acid desaturase 1	Homo sapiens	188-195
34008174-0	2021	Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice.	Fatty Acids, Unsaturated	112-138	fatty acid desaturase 2	Mus musculus	12-35
34008174-0	2021	Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice.	Fatty Acids, Unsaturated	112-138	fatty acid desaturase 2	Mus musculus	37-42
33991295-7	2021	Using analysis of variance, the monoacylglycerol factor, cholesterol ester factor, the factor for triacylglycerols that consist mostly of polyunsaturated fatty acids, sphingosine, and free carnitine significantly differed by APOE (p < 0.05, false discovery rate < 0.30).	Fatty Acids, Unsaturated	138-165	apolipoprotein E	Homo sapiens	225-229
33969684-0	2021	Characteristics of Metabolites by Seed-Specific Inhibition of FAD2 in Brassica napus L. Fatty acid desaturase-2 (FAD2) is a key enzyme in the production of polyunsaturated fatty acids in plants.	Fatty Acids, Unsaturated	156-183	omega-6 fatty acid desaturase, endoplasmic reticulum	Brassica napus	62-66
33969684-0	2021	Characteristics of Metabolites by Seed-Specific Inhibition of FAD2 in Brassica napus L. Fatty acid desaturase-2 (FAD2) is a key enzyme in the production of polyunsaturated fatty acids in plants.	Fatty Acids, Unsaturated	156-183	omega-6 fatty acid desaturase, endoplasmic reticulum	Brassica napus	88-111
33969684-0	2021	Characteristics of Metabolites by Seed-Specific Inhibition of FAD2 in Brassica napus L. Fatty acid desaturase-2 (FAD2) is a key enzyme in the production of polyunsaturated fatty acids in plants.	Fatty Acids, Unsaturated	156-183	omega-6 fatty acid desaturase, endoplasmic reticulum	Brassica napus	113-117
33963532-1	2021	The objective of the present study was to increase by dietary means the long-chain polyunsaturated fatty acid (LC-PUFA) n-3 content in selected meat products.	Fatty Acids, Unsaturated	83-109	Polyunsaturated fatty acid percentage	Sus scrofa	114-118
33990936-0	2021	Biocatalytic synthesis of dihydroxy fatty acids as lipid mediators from polyunsaturated fatty acids by double dioxygenation of the microbial 12S-lipoxygenase.	Fatty Acids, Unsaturated	72-99	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	141-157
33990936-5	2021	Here, we discovered a wild-type 12S-LOX with double dioxygenating activity from the bacterium Endozoicomonas numazuensis, which produced dihydroxy fatty acids (DiHFAs) as LMs from polyunsaturated fatty acids via double dioxygenation.	Fatty Acids, Unsaturated	180-207	lysyl oxidase	Homo sapiens	36-39
33982092-1	2021	PURPOSE: Although the role of n-6 polyunsaturated fatty acids (PUFAs) in age-related macular degeneration (AMD) has been studied in previous observational studies, the precise manner in which one or more n-6 PUFAs account for this relationship remains unclear.	Fatty Acids, Unsaturated	63-68	renin binding protein	Homo sapiens	73-76
34004336-1	2021	The aim of this study was to investigate the in vivo and in vitro effects of dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) and their derivatives on the expression of TP53 and their relationship with cellular proliferation and death in a murine mammary adenocarcinoma model.	Fatty Acids, Unsaturated	134-139	transformation related protein 53	Mus musculus	184-188
34016526-3	2021	By comprehensive analysis of the fatty acid profile, we found organ-specific accumulation and reduction of distinct fatty acid species, such as an accumulation of ultra-very-long-chain polyunsaturated fatty acids (ultra-VLC-PUFAs) in the brains of pex2 mutant fish.	Fatty Acids, Unsaturated	185-212	peroxisomal biogenesis factor 2	Homo sapiens	248-252
33871589-7	2021	Furthermore, we found that CDF-1/SUR-7 may functionally bypass SBP-1 to directly affect the conversion activity of SCD in the biosynthesis of unsaturated fatty acids and lipid accumulation.	Fatty Acids, Unsaturated	142-165	Cation diffusion facilitator family protein 1	Caenorhabditis elegans	27-32
33513444-0	2021	LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol.	Fatty Acids, Unsaturated	53-80	membrane bound O-acyltransferase domain containing 7	Homo sapiens	7-13
33513444-5	2021	MBOAT7 preferentially transferred 20:4 and 20:5 polyunsaturated fatty acids (PUFAs) to lysophosphatidylinositol (LPI).	Fatty Acids, Unsaturated	48-75	membrane bound O-acyltransferase domain containing 7	Homo sapiens	0-6
33513444-5	2021	MBOAT7 preferentially transferred 20:4 and 20:5 polyunsaturated fatty acids (PUFAs) to lysophosphatidylinositol (LPI).	Fatty Acids, Unsaturated	77-82	membrane bound O-acyltransferase domain containing 7	Homo sapiens	0-6
33513444-8	2021	Thus, MBOAT7 catalyzes the transfer of PUFAs to lipid acceptors.	Fatty Acids, Unsaturated	39-44	membrane bound O-acyltransferase domain containing 7	Homo sapiens	6-12
33947752-7	2021	Additionally, we found that increases in the elongation of polyunsaturated fatty acids (PUFAs) associated with HCMV infection were independent of PERK and that lipids with PUFA tails accumulated in HCMV-infected PERK knockout cells.	Fatty Acids, Unsaturated	59-86	pumilio RNA binding family member 3	Homo sapiens	88-92
33925035-2	2021	Cytochrome P450 oxygenates PUFAs to produce anti-inflammatory and pain-resolving epoxy fatty acids (EpFAs) and other oxylipins whose epoxide ring is opened by the soluble epoxide hydrolase (sEH/Ephx2), resulting in the formation of toxic and pro-inflammatory vicinal diols (dihydroxy-FAs).	Fatty Acids, Unsaturated	27-32	epoxide hydrolase 2	Homo sapiens	190-193
33925035-2	2021	Cytochrome P450 oxygenates PUFAs to produce anti-inflammatory and pain-resolving epoxy fatty acids (EpFAs) and other oxylipins whose epoxide ring is opened by the soluble epoxide hydrolase (sEH/Ephx2), resulting in the formation of toxic and pro-inflammatory vicinal diols (dihydroxy-FAs).	Fatty Acids, Unsaturated	27-32	epoxide hydrolase 2	Homo sapiens	194-199
33871589-7	2021	Furthermore, we found that CDF-1/SUR-7 may functionally bypass SBP-1 to directly affect the conversion activity of SCD in the biosynthesis of unsaturated fatty acids and lipid accumulation.	Fatty Acids, Unsaturated	142-165	SUppressor of activated let-60 Ras	Caenorhabditis elegans	33-38
33871589-7	2021	Furthermore, we found that CDF-1/SUR-7 may functionally bypass SBP-1 to directly affect the conversion activity of SCD in the biosynthesis of unsaturated fatty acids and lipid accumulation.	Fatty Acids, Unsaturated	142-165	BHLH domain-containing protein	Caenorhabditis elegans	63-68
33917814-1	2021	Polyunsaturated fatty acids (PUFA) are involved in brain disorders associated to amyloid beta (Abeta) toxicity for which oxidative stress, neurochemical dysfunctions, and neuroinflammation are underlying mechanisms.	Fatty Acids, Unsaturated	0-27	amyloid beta precursor protein	Rattus norvegicus	95-100
33917814-1	2021	Polyunsaturated fatty acids (PUFA) are involved in brain disorders associated to amyloid beta (Abeta) toxicity for which oxidative stress, neurochemical dysfunctions, and neuroinflammation are underlying mechanisms.	Fatty Acids, Unsaturated	29-33	amyloid beta precursor protein	Rattus norvegicus	95-100
33170092-10	2021	Nondiabetic patients with metabolic syndrome with higher PUFA consumption, including higher omega-3/omega-6 ratio, were characterized by higher circulating adiponectin level and more favorable biochemical profile.	Fatty Acids, Unsaturated	57-61	adiponectin, C1Q and collagen domain containing	Homo sapiens	156-167
33023764-9	2021	Unsaturated fatty acids including omega-3-PUFA and MUFA are considered as protective biomarkers in PC prevention.	Fatty Acids, Unsaturated	0-23	pumilio RNA binding family member 3	Homo sapiens	34-46
33676096-9	2021	Owing to the upregulated expression of acyl-CoA synthetase long-chain family member 4 detected in the yolk sac, we assumed that the ferroptosis of the yolk sac was perhaps caused by the accumulation of reactive oxygen species, which was induced by the large amount of polyunsaturated fatty acids and influx of iron in the yolk.	Fatty Acids, Unsaturated	268-295	acyl-CoA synthetase long chain family member 4	Gallus gallus	39-85
33502893-1	2021	Evidence suggests that n-3 polyunsaturated fatty acids (PUFA) may act as activators of the Nrf2 antioxidant pathway.	Fatty Acids, Unsaturated	56-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	91-95
33655337-12	2021	The findings suggested that a correlation between the HMGB1/RAGE pathway and biosynthesis of unsaturated fatty acids may contribute to the progression of HS-related AKI.	Fatty Acids, Unsaturated	93-116	high mobility group box 1	Mus musculus	54-59
33655337-12	2021	The findings suggested that a correlation between the HMGB1/RAGE pathway and biosynthesis of unsaturated fatty acids may contribute to the progression of HS-related AKI.	Fatty Acids, Unsaturated	93-116	advanced glycosylation end product-specific receptor	Mus musculus	60-64
33205365-2	2021	Rice bran is very rich in polyunsaturated fatty acids, which are reported to act as PPAR-gamma partial agonists.	Fatty Acids, Unsaturated	26-53	peroxisome proliferator activated receptor gamma	Mus musculus	84-94
33785360-6	2021	Accordingly, serum metabolomics of Oat1 knockout mice revealed increased polyunsaturated fatty acids, diacylglycerols, and long chain fatty acids, and decreased ceramides and bile acids when compared to wild type controls.	Fatty Acids, Unsaturated	73-100	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	35-39
33753501-7	2021	We showed that S. aureus instead scavenges host-derived unsaturated fatty acids from the skin using the secreted lipase, Geh, and the unsaturated fatty acid-binding protein, FakB2.	Fatty Acids, Unsaturated	56-79	lipase	Staphylococcus aureus	113-119
33753501-7	2021	We showed that S. aureus instead scavenges host-derived unsaturated fatty acids from the skin using the secreted lipase, Geh, and the unsaturated fatty acid-binding protein, FakB2.	Fatty Acids, Unsaturated	56-78	lipase	Staphylococcus aureus	113-119
32931040-11	2021	We speculate that polyunsaturated fatty acids of krill oil may dampen ERK activation by decreasing the phospholipid saturation of cell membrane.	Fatty Acids, Unsaturated	18-45	mitogen-activated protein kinase 1	Mus musculus	70-73
33664446-4	2021	In performing target-based ligand screening utilizing the RBD-SARS-CoV-2 sequence, we observed that polyunsaturated fatty acids most effectively interfere with binding to hACE2, the receptor for SARS-CoV-2.	Fatty Acids, Unsaturated	100-127	angiotensin converting enzyme 2	Homo sapiens	171-176
33444733-1	2021	s Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme for polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity.	Fatty Acids, Unsaturated	85-112	acyl-CoA synthetase long-chain family member 4	Mus musculus	2-48
33444733-1	2021	s Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme for polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity.	Fatty Acids, Unsaturated	85-112	acyl-CoA synthetase long-chain family member 4	Mus musculus	50-55
33444733-1	2021	s Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme for polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity.	Fatty Acids, Unsaturated	114-119	acyl-CoA synthetase long-chain family member 4	Mus musculus	2-48
33444733-1	2021	s Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme for polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity.	Fatty Acids, Unsaturated	114-119	acyl-CoA synthetase long-chain family member 4	Mus musculus	50-55
33444290-4	2021	Here we demonstrate that CoQ depletion caused by Pdss2 enzyme deficiency in podocytes results in perturbations in polyunsaturated fatty acid (PUFA) metabolism and the Braf/Mapk pathway, rather than ETC dysfunction.	Fatty Acids, Unsaturated	114-140	decaprenyl diphosphate synthase subunit 2	Homo sapiens	49-54
33444290-4	2021	Here we demonstrate that CoQ depletion caused by Pdss2 enzyme deficiency in podocytes results in perturbations in polyunsaturated fatty acid (PUFA) metabolism and the Braf/Mapk pathway, rather than ETC dysfunction.	Fatty Acids, Unsaturated	142-146	decaprenyl diphosphate synthase subunit 2	Homo sapiens	49-54
33430700-4	2021	However, the different effects of saturated fatty acids and unsaturated fatty acids on skeletal muscle are not fully differentiative capacity of C2C12 myoblasts by affecting Pax7, MyoD and MyoG, which are master regulators of lineage specification and the myogenic program.	Fatty Acids, Unsaturated	60-83	paired box 7	Mus musculus	174-178
33430700-4	2021	However, the different effects of saturated fatty acids and unsaturated fatty acids on skeletal muscle are not fully differentiative capacity of C2C12 myoblasts by affecting Pax7, MyoD and MyoG, which are master regulators of lineage specification and the myogenic program.	Fatty Acids, Unsaturated	60-83	myogenin	Mus musculus	189-193
33567271-4	2021	Gene silencing and stable isotope tracing demonstrate that direct Delta6 and Delta8 desaturation of 14:0 (myristic), 16:0 (palmitic), and 18:0 (stearic) acids by FADS2 generate new families of unsaturated fatty acids (including n-8, n-10, and n-12) that have rarely-if ever-been reported in human-derived cells.	Fatty Acids, Unsaturated	193-216	fatty acid desaturase 2	Homo sapiens	162-167
33639958-6	2021	The genome-wide alteration of gene expression was studied by high throughput sequencing analysis, where 75 genes were found to be dysregulated after SiNP exposure, among which ACOT2, SCD1, and CPT1A were demonstrated to regulate the biosynthesis of unsaturated fatty acids.	Fatty Acids, Unsaturated	249-272	acyl-CoA thioesterase 2	Mus musculus	176-181
33639958-6	2021	The genome-wide alteration of gene expression was studied by high throughput sequencing analysis, where 75 genes were found to be dysregulated after SiNP exposure, among which ACOT2, SCD1, and CPT1A were demonstrated to regulate the biosynthesis of unsaturated fatty acids.	Fatty Acids, Unsaturated	249-272	stearoyl-Coenzyme A desaturase 1	Mus musculus	183-187
33639958-6	2021	The genome-wide alteration of gene expression was studied by high throughput sequencing analysis, where 75 genes were found to be dysregulated after SiNP exposure, among which ACOT2, SCD1, and CPT1A were demonstrated to regulate the biosynthesis of unsaturated fatty acids.	Fatty Acids, Unsaturated	249-272	carnitine palmitoyltransferase 1a, liver	Mus musculus	193-198
33585963-1	2021	PURPOSE: Soluble epoxide hydrolase (sEH) is an enzyme with putative effect on neuroinflammation through its influence on the homeostasis of polyunsaturated fatty acids and related byproducts.	Fatty Acids, Unsaturated	140-167	epoxide hydrolase 2	Homo sapiens	9-34
33585963-1	2021	PURPOSE: Soluble epoxide hydrolase (sEH) is an enzyme with putative effect on neuroinflammation through its influence on the homeostasis of polyunsaturated fatty acids and related byproducts.	Fatty Acids, Unsaturated	140-167	epoxide hydrolase 2	Homo sapiens	36-39
33538574-0	2021	Polyunsaturated Fatty Acid Modulates Membrane-Bound Monomeric alpha-Synuclein by Modulating Membrane Microenvironment through Preferential Interactions.	Fatty Acids, Unsaturated	0-26	synuclein alpha	Homo sapiens	62-77
33538574-4	2021	DHA is a polyunsaturated fatty acid abundantly found in the brain and known to promote the oligomerization of alpha-synuclein.	Fatty Acids, Unsaturated	9-35	synuclein alpha	Homo sapiens	110-125
33567578-3	2021	Cytochrome (CYP) 450 metabolizes N-3 and N-6 polyunsaturated fatty acids (PUFA) into numerous lipid mediators, oxylipids, which are further metabolised by soluble epoxide hydrolase (sEH), reducing their activity.	Fatty Acids, Unsaturated	74-78	peptidylprolyl isomerase G	Homo sapiens	12-15
33567578-3	2021	Cytochrome (CYP) 450 metabolizes N-3 and N-6 polyunsaturated fatty acids (PUFA) into numerous lipid mediators, oxylipids, which are further metabolised by soluble epoxide hydrolase (sEH), reducing their activity.	Fatty Acids, Unsaturated	74-78	epoxide hydrolase 2	Homo sapiens	155-180
33567578-3	2021	Cytochrome (CYP) 450 metabolizes N-3 and N-6 polyunsaturated fatty acids (PUFA) into numerous lipid mediators, oxylipids, which are further metabolised by soluble epoxide hydrolase (sEH), reducing their activity.	Fatty Acids, Unsaturated	74-78	epoxide hydrolase 2	Homo sapiens	182-185
33549051-8	2021	Combined analyses of the transcriptome and metabolome revealed that glycolysis/gluconeogenesis and the insulin signaling pathway were down-regulated, the pentose phosphate pathway was activated, and the biosynthesis of unsaturated fatty acids and fatty acid metabolism were up-regulated in GIFT under hypoxia stress.	Fatty Acids, Unsaturated	219-242	insulin	Oreochromis niloticus	103-110
32578350-3	2021	Fatty acid-binding protein 3 (FABP3) is a carrier protein of polyunsaturated fatty acids (PUFAs) and participates in multiple cellular functions.	Fatty Acids, Unsaturated	61-88	fatty acid binding protein 3	Homo sapiens	0-28
33028621-3	2021	Specifically, the liver microenvironment induces metabolic adaptations via up-regulating expression of endothelial lipase (LIPG) in leukemia cells, which not only stimulates tumor cell proliferation through polyunsaturated fatty acid (PUFA) mediated pathways, but also promotes survival by stabilizing anti-apoptotic proteins.	Fatty Acids, Unsaturated	207-233	lipase G, endothelial type	Homo sapiens	103-121
33028621-3	2021	Specifically, the liver microenvironment induces metabolic adaptations via up-regulating expression of endothelial lipase (LIPG) in leukemia cells, which not only stimulates tumor cell proliferation through polyunsaturated fatty acid (PUFA) mediated pathways, but also promotes survival by stabilizing anti-apoptotic proteins.	Fatty Acids, Unsaturated	207-233	lipase G, endothelial type	Homo sapiens	123-127
33028621-3	2021	Specifically, the liver microenvironment induces metabolic adaptations via up-regulating expression of endothelial lipase (LIPG) in leukemia cells, which not only stimulates tumor cell proliferation through polyunsaturated fatty acid (PUFA) mediated pathways, but also promotes survival by stabilizing anti-apoptotic proteins.	Fatty Acids, Unsaturated	235-239	lipase G, endothelial type	Homo sapiens	103-121
33028621-3	2021	Specifically, the liver microenvironment induces metabolic adaptations via up-regulating expression of endothelial lipase (LIPG) in leukemia cells, which not only stimulates tumor cell proliferation through polyunsaturated fatty acid (PUFA) mediated pathways, but also promotes survival by stabilizing anti-apoptotic proteins.	Fatty Acids, Unsaturated	235-239	lipase G, endothelial type	Homo sapiens	123-127
32578350-3	2021	Fatty acid-binding protein 3 (FABP3) is a carrier protein of polyunsaturated fatty acids (PUFAs) and participates in multiple cellular functions.	Fatty Acids, Unsaturated	61-88	fatty acid binding protein 3	Homo sapiens	30-35
32578350-3	2021	Fatty acid-binding protein 3 (FABP3) is a carrier protein of polyunsaturated fatty acids (PUFAs) and participates in multiple cellular functions.	Fatty Acids, Unsaturated	90-95	fatty acid binding protein 3	Homo sapiens	0-28
32578350-3	2021	Fatty acid-binding protein 3 (FABP3) is a carrier protein of polyunsaturated fatty acids (PUFAs) and participates in multiple cellular functions.	Fatty Acids, Unsaturated	90-95	fatty acid binding protein 3	Homo sapiens	30-35
33309342-12	2021	Pyruvate carboxylase promoter 1 activity that is mediated by unsaturated fatty acids acting through elements within -1002 and -222 bp of bovine PCPI may determine PC response during periods of negative energy balance in dairy cows.	Fatty Acids, Unsaturated	61-84	pyruvate carboxylase	Bos taurus	0-20
33309342-0	2021	Bovine pyruvate carboxylase gene proximal promoter activity is regulated by saturated and unsaturated fatty acids in Madin-Darby bovine kidney cells.	Fatty Acids, Unsaturated	90-113	pyruvate carboxylase	Bos taurus	7-27
33303636-2	2021	We investigated whether there was an interaction between dietary fish intake or plasma phospholipid n-3 polyunsaturated fatty acid (PUFA) concentration with the 65-kDa isoform of GAD (GAD65) antibody positivity on the risk of developing adult-onset diabetes.	Fatty Acids, Unsaturated	132-136	glutamate decarboxylase 2	Homo sapiens	179-182
33309342-12	2021	Pyruvate carboxylase promoter 1 activity that is mediated by unsaturated fatty acids acting through elements within -1002 and -222 bp of bovine PCPI may determine PC response during periods of negative energy balance in dairy cows.	Fatty Acids, Unsaturated	61-84	pyruvate carboxylase	Bos taurus	144-146
33573124-5	2021	Interestingly, the production of ethyl esters showed opposite profiles in different strains due to the distinct expression of EEB1, indicating that the effect of UFAs on ethyl esters syntheses is strain-specificity.	Fatty Acids, Unsaturated	162-166	medium-chain fatty acid ethyl ester synthase/esterase	Saccharomyces cerevisiae S288C	126-130
33530607-2	2021	The research aimed at achieving an increase of protein and unsaturated fatty acid contents, making innovative and healthy pasta products that are able to step up fish consumption.	Fatty Acids, Unsaturated	59-81	solute carrier family 45 member 1	Homo sapiens	122-127
33525599-5	2021	PUFA treatment increased mRNA level of myogenic factor 5 (Myf5), which is involved in early stage of myoblast proliferation.	Fatty Acids, Unsaturated	0-4	myogenic factor 5	Mus musculus	39-56
33525599-5	2021	PUFA treatment increased mRNA level of myogenic factor 5 (Myf5), which is involved in early stage of myoblast proliferation.	Fatty Acids, Unsaturated	0-4	myogenic factor 5	Mus musculus	58-62
33573088-0	2021	In Silico Study of Polyunsaturated Fatty Acids as Potential SARS-CoV-2 Spike Protein Closed Conformation Stabilizers: Epidemiological and Computational Approaches.	Fatty Acids, Unsaturated	19-46	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	71-76
33515553-2	2021	Docosahexaenoic acid (DHA, 22:6Delta4,7,10,13,16,19), a chemoprotective long chain n-3 polyunsaturated fatty acid (PUFA) suppresses EGFR signaling.	Fatty Acids, Unsaturated	115-119	epidermal growth factor receptor	Mus musculus	132-136
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Fatty Acids, Unsaturated	304-330	cytochrome p450 oxidoreductase	Mus musculus	47-78
33497399-10	2021	Lastly, positive and negative correlations between miR-33a/b expression and saturated fatty acid (SFA) and polyunsaturated fatty acid (PUFA) content, respectively, were identified.	Fatty Acids, Unsaturated	107-133	Polyunsaturated fatty acid percentage	Sus scrofa	135-139
33504005-0	2021	MicroRNA-193a-5p Regulates the Synthesis of Polyunsaturated Fatty Acids by Targeting Fatty Acid Desaturase 1 (FADS1) in Bovine Mammary Epithelial Cells.	Fatty Acids, Unsaturated	44-71	microRNA 193a	Bos taurus	0-13
33504005-0	2021	MicroRNA-193a-5p Regulates the Synthesis of Polyunsaturated Fatty Acids by Targeting Fatty Acid Desaturase 1 (FADS1) in Bovine Mammary Epithelial Cells.	Fatty Acids, Unsaturated	44-71	fatty acid desaturase 1	Bos taurus	85-108
33504005-0	2021	MicroRNA-193a-5p Regulates the Synthesis of Polyunsaturated Fatty Acids by Targeting Fatty Acid Desaturase 1 (FADS1) in Bovine Mammary Epithelial Cells.	Fatty Acids, Unsaturated	44-71	fatty acid desaturase 1	Bos taurus	110-115
33483840-9	2021	Ether extract (EE) ratios increased (P < 0.01) and polyunsaturated fatty acid (PUFA)/saturated fatty acid (SFA) proportions decreased (P > 0.05) with increasing SWs.	Fatty Acids, Unsaturated	51-77	PUFA	Bos taurus	79-83
33494132-0	2021	Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?	Fatty Acids, Unsaturated	51-78	fatty acid desaturase 2	Homo sapiens	11-16
33494132-1	2021	Dietary polyphenols promote cardiometabolic health and are linked with long-chain polyunsaturated fatty acids in plasma phospholipids (LC-PUFA).	Fatty Acids, Unsaturated	82-109	pumilio RNA binding family member 3	Homo sapiens	138-142
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Fatty Acids, Unsaturated	304-330	cytochrome p450 oxidoreductase	Mus musculus	80-83
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Fatty Acids, Unsaturated	304-330	cytochrome b5 reductase 1	Mus musculus	119-125
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Fatty Acids, Unsaturated	332-336	cytochrome p450 oxidoreductase	Mus musculus	47-78
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Fatty Acids, Unsaturated	332-336	cytochrome p450 oxidoreductase	Mus musculus	80-83
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Fatty Acids, Unsaturated	332-336	cytochrome b5 reductase 1	Mus musculus	119-125
33203703-9	2021	Lipidomics analysis revealed an accumulation of polyunsaturated fatty acids (PUFA) in cells with FA2H overexpression, which may contribute to the observed nutrient deficiency and AMPK activation.	Fatty Acids, Unsaturated	48-75	fatty acid 2-hydroxylase	Homo sapiens	97-101
33465374-7	2021	The mRNA levels of Elovl2 and Elovl4, genes encoding enzymes essential for the synthesis of VLC polyunsaturated fatty acids, increased in developing photoreceptors.	Fatty Acids, Unsaturated	96-123	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	Mus musculus	19-25
33465374-7	2021	The mRNA levels of Elovl2 and Elovl4, genes encoding enzymes essential for the synthesis of VLC polyunsaturated fatty acids, increased in developing photoreceptors.	Fatty Acids, Unsaturated	96-123	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	30-36
33203703-9	2021	Lipidomics analysis revealed an accumulation of polyunsaturated fatty acids (PUFA) in cells with FA2H overexpression, which may contribute to the observed nutrient deficiency and AMPK activation.	Fatty Acids, Unsaturated	48-75	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	179-183
33203703-9	2021	Lipidomics analysis revealed an accumulation of polyunsaturated fatty acids (PUFA) in cells with FA2H overexpression, which may contribute to the observed nutrient deficiency and AMPK activation.	Fatty Acids, Unsaturated	77-81	fatty acid 2-hydroxylase	Homo sapiens	97-101
33203703-9	2021	Lipidomics analysis revealed an accumulation of polyunsaturated fatty acids (PUFA) in cells with FA2H overexpression, which may contribute to the observed nutrient deficiency and AMPK activation.	Fatty Acids, Unsaturated	77-81	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	179-183
33169127-0	2021	Quantitative Polyunsaturated Fatty Acid Analysis of Chia Seed Oil by High-Performance Liquid Chromatography.	Fatty Acids, Unsaturated	13-39	chitinase acidic	Homo sapiens	52-56
33169127-1	2021	Alpha-linolenic acid (ALA) and linoleic acid (LA), abundant in chia seed oil, are useful polyunsaturated fatty acids (PUFA) with numerous health benefits.	Fatty Acids, Unsaturated	89-116	chitinase acidic	Homo sapiens	63-67
33169127-1	2021	Alpha-linolenic acid (ALA) and linoleic acid (LA), abundant in chia seed oil, are useful polyunsaturated fatty acids (PUFA) with numerous health benefits.	Fatty Acids, Unsaturated	118-122	chitinase acidic	Homo sapiens	63-67
33376139-2	2021	Staphylococcus aureus uses OhyA to counteract the host innate immune response by inactivating antimicrobial unsaturated fatty acids.	Fatty Acids, Unsaturated	108-131	AT695_RS03350	Staphylococcus aureus	27-31
33451004-5	2021	The obtained coefficients (R2) for some FA, such as alpha-linolenic acid with a R2 = 0.96 or n-3 polyunsaturated fatty acids (n-3 PUFA) with R2 = 0.93, demonstrate that FT-MIR spectroscopy is a valid technique to estimate the content of FA.	Fatty Acids, Unsaturated	97-124	membrane associated ring-CH-type finger 8	Homo sapiens	172-175
33446880-7	2021	Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r =  - 0.168) and interleukin-6 concentrations (r =  - 0.115).	Fatty Acids, Unsaturated	53-58	interleukin 6	Homo sapiens	110-123
33419037-5	2021	Among these, the rs110817643C>T, located in the seed sequence of the bta-miR-1291, was associated with different omega6 FAs, polyunsaturated FA, and polyunsaturated:saturated FA ratios.	Fatty Acids, Unsaturated	125-143	microRNA 1291	Bos taurus	69-81
33397237-0	2021	Distinct Modulation of Wild-Type and Selective Gene Mutated Vitamin D Receptor by Essential Poly Unsaturated Fatty Acids.	Fatty Acids, Unsaturated	92-120	vitamin D receptor	Homo sapiens	60-78
33397237-4	2021	A plethora of evidence report that selective long chain polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) bind to the ligand-binding domain of VDR and lead to transcriptional activation.	Fatty Acids, Unsaturated	85-90	vitamin D receptor	Homo sapiens	221-224
33553325-6	2021	Changes in the gut microbiota of IgAN affected the metabolism and absorbance of microbiota-associated metabolites, in particular polyunsaturated fatty acids, free amino acid, and oligopeptides, and activated the phenylalanine metabolism pathway, thereby constructing a unique metabolic system of IgAN.	Fatty Acids, Unsaturated	129-156	IGAN1	Homo sapiens	33-37
33372166-3	2021	Among the GPCRs for free fatty acids, free fatty acid receptor 4 (FFA4, also known as GPR120) recognizes long-chain polyunsaturated fatty acids such as DHA and EPA.	Fatty Acids, Unsaturated	116-143	free fatty acid receptor 4	Homo sapiens	38-64
32979157-5	2021	Notably, lipids (cholesterol, plasmalogens, squalene, and unsaturated fatty acids) can act as cellular signals that either promote or reduce SM degradation.	Fatty Acids, Unsaturated	58-81	squalene epoxidase	Homo sapiens	141-143
33372166-3	2021	Among the GPCRs for free fatty acids, free fatty acid receptor 4 (FFA4, also known as GPR120) recognizes long-chain polyunsaturated fatty acids such as DHA and EPA.	Fatty Acids, Unsaturated	116-143	free fatty acid receptor 4	Homo sapiens	66-70
33372166-3	2021	Among the GPCRs for free fatty acids, free fatty acid receptor 4 (FFA4, also known as GPR120) recognizes long-chain polyunsaturated fatty acids such as DHA and EPA.	Fatty Acids, Unsaturated	116-143	free fatty acid receptor 4	Homo sapiens	86-92
33310680-1	2021	Numerous studies have reported an association between genetic variants in fatty acid desaturases (FADS1 and FADS2) and plasma or erythrocyte long chain polyunsaturated fatty acid (PUFA) levels.	Fatty Acids, Unsaturated	180-184	fatty acid desaturase 1	Homo sapiens	98-103
33530084-7	2021	In addition, genetic variants in FADS1, FADS2, ELOV-2, and ELOV-5 lead to a more efficient biosynthesis of long-chain polyunsaturated fatty acids (PUFAs), e.g., of linoleic acid (LA) to arachidonic acid (ARA), and (alpha-linolenic acid) (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), leading to higher ARA levels.	Fatty Acids, Unsaturated	147-152	fatty acid desaturase 1	Homo sapiens	33-38
33530084-7	2021	In addition, genetic variants in FADS1, FADS2, ELOV-2, and ELOV-5 lead to a more efficient biosynthesis of long-chain polyunsaturated fatty acids (PUFAs), e.g., of linoleic acid (LA) to arachidonic acid (ARA), and (alpha-linolenic acid) (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), leading to higher ARA levels.	Fatty Acids, Unsaturated	147-152	fatty acid desaturase 2	Homo sapiens	40-45
33310680-1	2021	Numerous studies have reported an association between genetic variants in fatty acid desaturases (FADS1 and FADS2) and plasma or erythrocyte long chain polyunsaturated fatty acid (PUFA) levels.	Fatty Acids, Unsaturated	180-184	fatty acid desaturase 2	Homo sapiens	108-113
33302552-7	2020	Unlike SFAs, unsaturated fatty acids do not promote GDF15 expression and rather inhibit both SFA-induced GDF15 expression and ER stress.	Fatty Acids, Unsaturated	13-36	growth differentiation factor 15	Homo sapiens	105-110
33681679-1	2021	The fatty acid desaturase 1 (FADS1), also known as delta-5 desaturase (D5D), is one of the rate-limiting enzymes involved in the desaturation and elongation cascade of polyunsaturated fatty acids (PUFAs) to generate long-chain PUFAs (LC-PUFAs).	Fatty Acids, Unsaturated	168-195	fatty acid desaturase 1	Mus musculus	51-69
33681679-1	2021	The fatty acid desaturase 1 (FADS1), also known as delta-5 desaturase (D5D), is one of the rate-limiting enzymes involved in the desaturation and elongation cascade of polyunsaturated fatty acids (PUFAs) to generate long-chain PUFAs (LC-PUFAs).	Fatty Acids, Unsaturated	168-195	fatty acid desaturase 1	Mus musculus	71-74
33339154-3	2020	We investigated the potency of peroxisome proliferator-activated receptor (PPAR) ligands to modulate the stimulating effect of lipopolysaccharide (LPS) in the primary rat astrocytes on (1) polyunsaturated fatty acid (PUFAs) derivative (oxylipins) synthesis; (2) cytokines TNFalpha and interleukin-10 (IL-10) release; (3) p38, JNK, ERK mitogen-activated protein kinase (MAPKs) phosphorylation.	Fatty Acids, Unsaturated	189-215	peroxisome proliferator activated receptor alpha	Rattus norvegicus	75-79
33339154-3	2020	We investigated the potency of peroxisome proliferator-activated receptor (PPAR) ligands to modulate the stimulating effect of lipopolysaccharide (LPS) in the primary rat astrocytes on (1) polyunsaturated fatty acid (PUFAs) derivative (oxylipins) synthesis; (2) cytokines TNFalpha and interleukin-10 (IL-10) release; (3) p38, JNK, ERK mitogen-activated protein kinase (MAPKs) phosphorylation.	Fatty Acids, Unsaturated	217-222	peroxisome proliferator activated receptor alpha	Rattus norvegicus	31-73
33339154-3	2020	We investigated the potency of peroxisome proliferator-activated receptor (PPAR) ligands to modulate the stimulating effect of lipopolysaccharide (LPS) in the primary rat astrocytes on (1) polyunsaturated fatty acid (PUFAs) derivative (oxylipins) synthesis; (2) cytokines TNFalpha and interleukin-10 (IL-10) release; (3) p38, JNK, ERK mitogen-activated protein kinase (MAPKs) phosphorylation.	Fatty Acids, Unsaturated	217-222	peroxisome proliferator activated receptor alpha	Rattus norvegicus	75-79
33396527-5	2020	Our results also revealed that arachidonic acid, linoleic acid and docosahexanoic acid are key polyunsaturated fatty acid substrates for ALOX15.	Fatty Acids, Unsaturated	95-121	arachidonate 15-lipoxygenase	Homo sapiens	137-143
33681679-1	2021	The fatty acid desaturase 1 (FADS1), also known as delta-5 desaturase (D5D), is one of the rate-limiting enzymes involved in the desaturation and elongation cascade of polyunsaturated fatty acids (PUFAs) to generate long-chain PUFAs (LC-PUFAs).	Fatty Acids, Unsaturated	168-195	fatty acid desaturase 1	Mus musculus	4-27
33681679-1	2021	The fatty acid desaturase 1 (FADS1), also known as delta-5 desaturase (D5D), is one of the rate-limiting enzymes involved in the desaturation and elongation cascade of polyunsaturated fatty acids (PUFAs) to generate long-chain PUFAs (LC-PUFAs).	Fatty Acids, Unsaturated	168-195	fatty acid desaturase 1	Mus musculus	29-34
33331250-0	2021	Association between FADS1 rs174547 and levels of long-chain polyunsaturated fatty acids: a meta-analysis.	Fatty Acids, Unsaturated	60-87	fatty acid desaturase 1	Homo sapiens	20-25
33331250-1	2021	In this study, we analysed the effects of single nucleotide polymorphism (SNP) rs174547 (T/C) in the fatty acid desaturase 1 (FADS1) gene on long-chain polyunsaturated fatty acid levels.	Fatty Acids, Unsaturated	152-178	fatty acid desaturase 1	Homo sapiens	101-124
33331250-1	2021	In this study, we analysed the effects of single nucleotide polymorphism (SNP) rs174547 (T/C) in the fatty acid desaturase 1 (FADS1) gene on long-chain polyunsaturated fatty acid levels.	Fatty Acids, Unsaturated	152-178	fatty acid desaturase 1	Homo sapiens	126-131
33308320-0	2020	Isotope-reinforced polyunsaturated fatty acids improve Parkinson"s disease-like phenotype in rats overexpressing alpha-synuclein.	Fatty Acids, Unsaturated	19-46	synuclein alpha	Rattus norvegicus	113-128
33094384-1	2020	Delta6 fatty acid desaturases (FADS6) have different substrate specificities that impact the ratio of omega-6/omega-3 polyunsaturated fatty acids, which are involved in regulating multiple signalling pathways associated with various diseases.	Fatty Acids, Unsaturated	118-145	fatty acid desaturase 6	Homo sapiens	31-36
33273482-4	2020	Obese NLRP3 deficient mice had lower systemic ceramide levels, potentially resulting attenuating inflammation, altered hepatic expression of fatty acids (FA) with lower mono-saturated FA and higher polyunsaturated FA levels, potentially counteracting development of liver steatosis, downregulated myocardial energy metabolism as assessed by proteomic analyses of LV heart tissue, and different levels of bile acids as compared with WT mice.	Fatty Acids, Unsaturated	198-216	NLR family, pyrin domain containing 3	Mus musculus	6-11
32755565-4	2020	In this study, using CYP4V2 mutant pluripotent stem cells as disease models, we demonstrated that RPE cells with CYP4V2 mutations presented a disrupted fatty acid homeostasis, which were characterized with excessive accumulation of poly-unsaturated fatty acid (PUFA), including arachidonic acid (AA) and eicosapentaenoic acid (EPA).	Fatty Acids, Unsaturated	232-259	cytochrome P450 family 4 subfamily V member 2	Homo sapiens	113-119
32755565-4	2020	In this study, using CYP4V2 mutant pluripotent stem cells as disease models, we demonstrated that RPE cells with CYP4V2 mutations presented a disrupted fatty acid homeostasis, which were characterized with excessive accumulation of poly-unsaturated fatty acid (PUFA), including arachidonic acid (AA) and eicosapentaenoic acid (EPA).	Fatty Acids, Unsaturated	261-265	cytochrome P450 family 4 subfamily V member 2	Homo sapiens	113-119
32755565-5	2020	The PUFA overload increased mitochondrial reactive oxygen species, impaired mitochondrial respiratory functions, and triggered mitochondrial stress-activated p53-independent apoptosis in CYP4V2 mutant RPE cells.	Fatty Acids, Unsaturated	4-8	tumor protein p53	Homo sapiens	158-161
32755565-5	2020	The PUFA overload increased mitochondrial reactive oxygen species, impaired mitochondrial respiratory functions, and triggered mitochondrial stress-activated p53-independent apoptosis in CYP4V2 mutant RPE cells.	Fatty Acids, Unsaturated	4-8	cytochrome P450 family 4 subfamily V member 2	Homo sapiens	187-193
33414988-2	2020	In recent years, more and more studies have been conducted on fatty acid desaturase 2 (FADS2), the first rate-limiting enzyme for the biosynthesis of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	150-177	fatty acid desaturase 2	Homo sapiens	62-85
33414988-2	2020	In recent years, more and more studies have been conducted on fatty acid desaturase 2 (FADS2), the first rate-limiting enzyme for the biosynthesis of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	150-177	fatty acid desaturase 2	Homo sapiens	87-92
32985761-10	2020	Treatment with both TCDD and PUFAs collaboratively enhanced the levels of AHR, CYP1A1, p53, p21, Rb and regucalcin.	Fatty Acids, Unsaturated	29-34	aryl hydrocarbon receptor	Homo sapiens	74-77
32985761-0	2020	An aryl hydrocarbon receptor agonist suppresses the growth of human umbilical vein endothelial cells in vitro: Potent effect with polyunsaturated fatty acids.	Fatty Acids, Unsaturated	130-157	aryl hydrocarbon receptor	Homo sapiens	3-28
32985761-10	2020	Treatment with both TCDD and PUFAs collaboratively enhanced the levels of AHR, CYP1A1, p53, p21, Rb and regucalcin.	Fatty Acids, Unsaturated	29-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-85
32985761-7	2020	Treatment with polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid, suppressed the proliferation and stimulated the death of HUVEC in vitro, and decreased the levels of Stat3, MAPK/Erk1/2 and phospho-MAPK/Erk1/2 and increased caspase-3.	Fatty Acids, Unsaturated	15-42	signal transducer and activator of transcription 3	Homo sapiens	229-234
32985761-7	2020	Treatment with polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid, suppressed the proliferation and stimulated the death of HUVEC in vitro, and decreased the levels of Stat3, MAPK/Erk1/2 and phospho-MAPK/Erk1/2 and increased caspase-3.	Fatty Acids, Unsaturated	15-42	mitogen-activated protein kinase 3	Homo sapiens	241-247
32985761-10	2020	Treatment with both TCDD and PUFAs collaboratively enhanced the levels of AHR, CYP1A1, p53, p21, Rb and regucalcin.	Fatty Acids, Unsaturated	29-34	tumor protein p53	Homo sapiens	87-90
32985761-7	2020	Treatment with polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid, suppressed the proliferation and stimulated the death of HUVEC in vitro, and decreased the levels of Stat3, MAPK/Erk1/2 and phospho-MAPK/Erk1/2 and increased caspase-3.	Fatty Acids, Unsaturated	15-42	mitogen-activated protein kinase 3	Homo sapiens	265-271
32985761-7	2020	Treatment with polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid, suppressed the proliferation and stimulated the death of HUVEC in vitro, and decreased the levels of Stat3, MAPK/Erk1/2 and phospho-MAPK/Erk1/2 and increased caspase-3.	Fatty Acids, Unsaturated	15-42	caspase 3	Homo sapiens	286-295
32985761-10	2020	Treatment with both TCDD and PUFAs collaboratively enhanced the levels of AHR, CYP1A1, p53, p21, Rb and regucalcin.	Fatty Acids, Unsaturated	29-34	H3 histone pseudogene 16	Homo sapiens	92-95
32985761-7	2020	Treatment with polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid, suppressed the proliferation and stimulated the death of HUVEC in vitro, and decreased the levels of Stat3, MAPK/Erk1/2 and phospho-MAPK/Erk1/2 and increased caspase-3.	Fatty Acids, Unsaturated	44-49	signal transducer and activator of transcription 3	Homo sapiens	229-234
32985761-7	2020	Treatment with polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid, suppressed the proliferation and stimulated the death of HUVEC in vitro, and decreased the levels of Stat3, MAPK/Erk1/2 and phospho-MAPK/Erk1/2 and increased caspase-3.	Fatty Acids, Unsaturated	44-49	mitogen-activated protein kinase 3	Homo sapiens	241-247
32985761-10	2020	Treatment with both TCDD and PUFAs collaboratively enhanced the levels of AHR, CYP1A1, p53, p21, Rb and regucalcin.	Fatty Acids, Unsaturated	29-34	regucalcin	Homo sapiens	104-114
32985761-7	2020	Treatment with polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid, suppressed the proliferation and stimulated the death of HUVEC in vitro, and decreased the levels of Stat3, MAPK/Erk1/2 and phospho-MAPK/Erk1/2 and increased caspase-3.	Fatty Acids, Unsaturated	44-49	mitogen-activated protein kinase 3	Homo sapiens	265-271
32985761-7	2020	Treatment with polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid, suppressed the proliferation and stimulated the death of HUVEC in vitro, and decreased the levels of Stat3, MAPK/Erk1/2 and phospho-MAPK/Erk1/2 and increased caspase-3.	Fatty Acids, Unsaturated	44-49	caspase 3	Homo sapiens	286-295
32896112-2	2020	Since soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids plays a key role in the pain, sEH inhibitors would be promising new therapeutic drugs for neuropathic pain.	Fatty Acids, Unsaturated	59-86	epoxide hydrolase 2, cytoplasmic	Mus musculus	6-31
32534376-2	2020	As a cofactor of delta-5 desaturase (D5D) and delta-6 desaturase (D6D), and gene expression regulator, zinc may play a role modulating membrane flexibility by increasing membrane polyunsaturated fatty acids (PUFA) abundance.	Fatty Acids, Unsaturated	179-206	fatty acid desaturase 1	Homo sapiens	17-35
32534376-2	2020	As a cofactor of delta-5 desaturase (D5D) and delta-6 desaturase (D6D), and gene expression regulator, zinc may play a role modulating membrane flexibility by increasing membrane polyunsaturated fatty acids (PUFA) abundance.	Fatty Acids, Unsaturated	208-212	fatty acid desaturase 1	Homo sapiens	17-35
32534376-2	2020	As a cofactor of delta-5 desaturase (D5D) and delta-6 desaturase (D6D), and gene expression regulator, zinc may play a role modulating membrane flexibility by increasing membrane polyunsaturated fatty acids (PUFA) abundance.	Fatty Acids, Unsaturated	208-212	fatty acid desaturase 2	Homo sapiens	46-64
32534376-2	2020	As a cofactor of delta-5 desaturase (D5D) and delta-6 desaturase (D6D), and gene expression regulator, zinc may play a role modulating membrane flexibility by increasing membrane polyunsaturated fatty acids (PUFA) abundance.	Fatty Acids, Unsaturated	208-212	fatty acid desaturase 2	Homo sapiens	66-69
32896112-2	2020	Since soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids plays a key role in the pain, sEH inhibitors would be promising new therapeutic drugs for neuropathic pain.	Fatty Acids, Unsaturated	59-86	epoxide hydrolase 2	Homo sapiens	33-36
32896112-2	2020	Since soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids plays a key role in the pain, sEH inhibitors would be promising new therapeutic drugs for neuropathic pain.	Fatty Acids, Unsaturated	59-86	epoxide hydrolase 2	Homo sapiens	117-120
33207662-0	2020	Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.	Fatty Acids, Unsaturated	30-57	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
33098867-0	2020	Effects of overexpression of ACSL1 gene on the synthesis of unsaturated fatty acids in adipocytes of bovine.	Fatty Acids, Unsaturated	60-83	fatty-acid-Coenzyme A ligase long chain 2	Bos taurus	29-34
33791028-0	2020	Increased quality of in natura and cryopreserved semen of water buffaloes supplemented with saturated and unsaturated fatty acids from the palm oil industry.	Fatty Acids, Unsaturated	106-129	paralemmin-1	Bubalus bubalis	139-143
33098867-9	2020	Furthermore, the overexpression of ACSL1 enhanced the proportion of eicosapentaenoic acid (EPA), decreased the proportion of C22:4, and significantly upregulated polyunsaturated fatty acid (PUFA) content.	Fatty Acids, Unsaturated	162-188	fatty-acid-Coenzyme A ligase long chain 2	Bos taurus	35-40
33098867-9	2020	Furthermore, the overexpression of ACSL1 enhanced the proportion of eicosapentaenoic acid (EPA), decreased the proportion of C22:4, and significantly upregulated polyunsaturated fatty acid (PUFA) content.	Fatty Acids, Unsaturated	190-194	fatty-acid-Coenzyme A ligase long chain 2	Bos taurus	35-40
32846215-2	2020	For the first time, strong inverse relations of c-Rel with apolipoprotein B were observed across the cycle, while those with LDL cholesterol, triglycerides as well as saturated (SFA), particularly C14-C22 SFA, monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) clustered at T2.	Fatty Acids, Unsaturated	238-265	REL proto-oncogene, NF-kB subunit	Homo sapiens	48-53
33207662-4	2020	Recent research demonstrated that the oxidized metabolites, particularly the cytochrome P450 (CYP) metabolites, of PUFAs are beneficial to several neurodegenerative diseases, including Alzheimer"s disease and Parkinson"s disease; however, their mechanism(s) remains unclear.	Fatty Acids, Unsaturated	115-120	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	77-92
33207662-4	2020	Recent research demonstrated that the oxidized metabolites, particularly the cytochrome P450 (CYP) metabolites, of PUFAs are beneficial to several neurodegenerative diseases, including Alzheimer"s disease and Parkinson"s disease; however, their mechanism(s) remains unclear.	Fatty Acids, Unsaturated	115-120	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	94-97
33207662-8	2020	We will also discuss the potential mechanism(s) of CYP PUFA metabolites in neurodegeneration, which will ultimately improve our understanding of how PUFAs affect neurodegeneration and may identify potential drug targets for neurodegenerative diseases.	Fatty Acids, Unsaturated	55-59	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	51-54
33204880-2	2020	They are characterized by producing and accumulating great amount of lipids in their cells, especially long chain polyunsaturated fatty acids (LC-PUFA), highlighting the docosahexaenoic acid (DHA, 22:6, n-3), eicosapentaenoic acid (EPA, 20:5, n-3) and arachidonic acid (ARA, 20:4, n-6), as well as pigments of interest for human health and animal nutrition, such as carotenoids.	Fatty Acids, Unsaturated	114-141	pumilio RNA binding family member 3	Homo sapiens	146-150
32883522-0	2020	Polyunsaturated fatty acids synthesized by freshwater fish: A new insight to the roles of elovl2 and elovl5 in vivo.	Fatty Acids, Unsaturated	0-27	ELOVL fatty acid elongase 2	Danio rerio	90-96
32883522-0	2020	Polyunsaturated fatty acids synthesized by freshwater fish: A new insight to the roles of elovl2 and elovl5 in vivo.	Fatty Acids, Unsaturated	0-27	ELOVL fatty acid elongase 5	Danio rerio	101-107
33312521-6	2020	Furthermore, mixtures of these unsaturated fatty acids (UFAs) at the natural ratio (1:8:16) significantly induced neurite outgrowth and gene expression of NGF, NF160, and NPY in a dose-dependent manner.	Fatty Acids, Unsaturated	31-54	nerve growth factor	Homo sapiens	155-158
33312521-6	2020	Furthermore, mixtures of these unsaturated fatty acids (UFAs) at the natural ratio (1:8:16) significantly induced neurite outgrowth and gene expression of NGF, NF160, and NPY in a dose-dependent manner.	Fatty Acids, Unsaturated	31-54	neuropeptide Y	Homo sapiens	171-174
33312521-6	2020	Furthermore, mixtures of these unsaturated fatty acids (UFAs) at the natural ratio (1:8:16) significantly induced neurite outgrowth and gene expression of NGF, NF160, and NPY in a dose-dependent manner.	Fatty Acids, Unsaturated	56-60	nerve growth factor	Homo sapiens	155-158
33312521-6	2020	Furthermore, mixtures of these unsaturated fatty acids (UFAs) at the natural ratio (1:8:16) significantly induced neurite outgrowth and gene expression of NGF, NF160, and NPY in a dose-dependent manner.	Fatty Acids, Unsaturated	56-60	neuropeptide Y	Homo sapiens	171-174
33159224-9	2021	Dietary intake of monounsaturated fatty acid (MUFA) and polyunsaturated fatty acids (PUFA) had positive significant associations with the expression of FTO in visceral (STZbeta = 0.227, P = 0.023; STZbeta = 0.346, P < 0.001, respectively) and subcutaneous (STZbeta = 0.227, P = 0.026; STZbeta = 0.274, P = 0.006, respectively) adipose tissues.	Fatty Acids, Unsaturated	56-83	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	152-155
33159224-9	2021	Dietary intake of monounsaturated fatty acid (MUFA) and polyunsaturated fatty acids (PUFA) had positive significant associations with the expression of FTO in visceral (STZbeta = 0.227, P = 0.023; STZbeta = 0.346, P < 0.001, respectively) and subcutaneous (STZbeta = 0.227, P = 0.026; STZbeta = 0.274, P = 0.006, respectively) adipose tissues.	Fatty Acids, Unsaturated	85-89	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	152-155
32394023-3	2020	One of the first documented biochemical defects in CF, which predates the cloning of CFTR gene for almost three decades, is an imbalance in the levels of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	154-181	CF transmembrane conductance regulator	Homo sapiens	85-89
32394023-3	2020	One of the first documented biochemical defects in CF, which predates the cloning of CFTR gene for almost three decades, is an imbalance in the levels of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	183-188	CF transmembrane conductance regulator	Homo sapiens	85-89
32931072-3	2020	In particular, alpha-synuclein can interact with arachidonic acid (AA), a polyunsaturated fatty acid, in a manner that promotes the formation of alpha-helix enriched assemblies.	Fatty Acids, Unsaturated	74-100	synuclein alpha	Homo sapiens	15-30
33038834-3	2020	SARS-CoV (2003) induces Cox-2, catalyzing the synthesis, from highly unsaturated fatty acids (HUFA), of eicosanoids and docosanoids that mediate both inflammation and thrombosis.	Fatty Acids, Unsaturated	69-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
32885854-5	2020	Following verification study using mutants confirmed that the daf-2 gene rather than the daf-16 gene was required in LFBE and main components regulating lipid metabolism, which also involved in the process of fatty acid beta-oxidation and unsaturated fatty acid synthesis.	Fatty Acids, Unsaturated	239-261	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	62-67
32979455-0	2020	Modulatory role of dietary polyunsaturated fatty acids in Nrf2-mediated redox homeostasis.	Fatty Acids, Unsaturated	27-54	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
33038835-1	2020	Double lipoxygenation of polyunsaturated fatty acids having at least three methylene-interrupted double bonds can be made by two lipoxygenases, e.g. 5- and 12-LOX, or 15-LOX only, followed by reduction of the hydroperoxide products through the glutathione peroxidase action.	Fatty Acids, Unsaturated	25-52	arachidonate 15-lipoxygenase	Homo sapiens	156-162
33038835-1	2020	Double lipoxygenation of polyunsaturated fatty acids having at least three methylene-interrupted double bonds can be made by two lipoxygenases, e.g. 5- and 12-LOX, or 15-LOX only, followed by reduction of the hydroperoxide products through the glutathione peroxidase action.	Fatty Acids, Unsaturated	25-52	arachidonate 15-lipoxygenase	Homo sapiens	167-173
33114125-2	2020	They are a good source of long chain-polyunsaturated fatty acids (n-3 LC PUFA).	Fatty Acids, Unsaturated	37-64	pumilio RNA binding family member 3	Homo sapiens	73-77
33169581-1	2020	In most insects, polyunsaturated fatty acids (PUFAs) are mainly polyunsaturated fatty acids with a carbon-chain length less than 18 carbon atoms, hardly any long-chain polyunsaturated fatty acids such as C20 and C22 that are more valuable and bioactive.	Fatty Acids, Unsaturated	17-44	glaikit	Drosophila melanogaster	212-215
33169581-1	2020	In most insects, polyunsaturated fatty acids (PUFAs) are mainly polyunsaturated fatty acids with a carbon-chain length less than 18 carbon atoms, hardly any long-chain polyunsaturated fatty acids such as C20 and C22 that are more valuable and bioactive.	Fatty Acids, Unsaturated	46-51	glaikit	Drosophila melanogaster	212-215
33169581-5	2020	At the same time, expression of Elovl5 gene significantly contributed to the transformation of fruit flies C18-polyunsaturated fatty acids in the body towards the biosynthesis of longer-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	111-138	l(3)C18	Drosophila melanogaster	107-110
33169581-6	2020	The transgenic fruit fly model rich in long-chain polyunsaturated fatty acids such as C20 and C22 were obtained, providing a basis for further research on biosynthesis of polyunsaturated fatty acids in fruit flies.	Fatty Acids, Unsaturated	50-77	glaikit	Drosophila melanogaster	94-97
33169581-6	2020	The transgenic fruit fly model rich in long-chain polyunsaturated fatty acids such as C20 and C22 were obtained, providing a basis for further research on biosynthesis of polyunsaturated fatty acids in fruit flies.	Fatty Acids, Unsaturated	171-198	glaikit	Drosophila melanogaster	94-97
32270281-0	2020	Associations of whole blood polyunsaturated fatty acids and insulin resistance among European children and adolescents.	Fatty Acids, Unsaturated	28-55	insulin	Homo sapiens	60-67
33090507-1	2021	BACKGROUND: Fatty acid-binding protein 3 (FABP3) is a cytosolic carrier protein of polyunsaturated fatty acids (PUFAs) and regulates cellular metabolism.	Fatty Acids, Unsaturated	83-110	fatty acid binding protein 3, muscle and heart	Mus musculus	12-40
33090507-1	2021	BACKGROUND: Fatty acid-binding protein 3 (FABP3) is a cytosolic carrier protein of polyunsaturated fatty acids (PUFAs) and regulates cellular metabolism.	Fatty Acids, Unsaturated	83-110	fatty acid binding protein 3, muscle and heart	Mus musculus	42-47
33090507-1	2021	BACKGROUND: Fatty acid-binding protein 3 (FABP3) is a cytosolic carrier protein of polyunsaturated fatty acids (PUFAs) and regulates cellular metabolism.	Fatty Acids, Unsaturated	112-117	fatty acid binding protein 3, muscle and heart	Mus musculus	12-40
33090507-1	2021	BACKGROUND: Fatty acid-binding protein 3 (FABP3) is a cytosolic carrier protein of polyunsaturated fatty acids (PUFAs) and regulates cellular metabolism.	Fatty Acids, Unsaturated	112-117	fatty acid binding protein 3, muscle and heart	Mus musculus	42-47
32935676-7	2020	The results indicated that miR-497 could inhibit the production of triglycerides (TAG) and unsaturated fatty acids in bovine mammary epithelial cells (BMECs).	Fatty Acids, Unsaturated	91-114	microRNA 497	Bos taurus	27-34
32935676-8	2020	In contrast, LATS2 can promote the production of TAG and unsaturated fatty acids.	Fatty Acids, Unsaturated	57-80	large tumor suppressor kinase 2	Bos taurus	13-18
33081100-7	2020	Further analysis of fatty acid composition revealed that pigs with high expression of ssc-miR-451 had higher monounsaturated fatty acid (MUFA) and lower polyunsaturated fatty acid (PUFA).	Fatty Acids, Unsaturated	153-179	microRNA 451	Sus scrofa	86-97
33081100-7	2020	Further analysis of fatty acid composition revealed that pigs with high expression of ssc-miR-451 had higher monounsaturated fatty acid (MUFA) and lower polyunsaturated fatty acid (PUFA).	Fatty Acids, Unsaturated	181-185	microRNA 451	Sus scrofa	86-97
33123132-0	2020	Polyunsaturated Fatty Acids Influence LPS-Induced Inflammation of Fish Macrophages Through Differential Modulation of Pathogen Recognition and p38 MAPK/NF-kappaB Signaling.	Fatty Acids, Unsaturated	0-27	nuclear factor kappa B subunit 1	Homo sapiens	152-161
33568263-3	2020	Ferroptosis is stimulated in tumours with inherently high levels of ferrous ions by a reaction with abundant polyunsaturated fatty acids and the inhibition of antioxidant enzymes, which can overcome treatment resistance in cancers mainly through GPX4.	Fatty Acids, Unsaturated	109-136	glutathione peroxidase 4	Homo sapiens	246-250
32008872-1	2020	BACKGROUND & AIMS: Omega-6 polyunsaturated fatty acids (PUFAs) have been shown to relate to insulin resistance and type 2 diabetes (T2D), but influence of race/ethnicity has not been investigated.	Fatty Acids, Unsaturated	56-61	insulin	Homo sapiens	92-99
32270281-1	2020	This study aims to examine the association of whole blood n-3 and n-6 polyunsaturated fatty acids (PUFA) with insulin resistance (IR) in children.	Fatty Acids, Unsaturated	99-103	insulin	Homo sapiens	110-117
32020589-7	2020	PUFAs stimulated AMP activated protein kinase-alpha (AMPK-alpha) as well as peroxisome proliferator-activated receptor-alpha (PPAR-alpha).	Fatty Acids, Unsaturated	0-5	peroxisome proliferator activated receptor alpha	Mus musculus	76-124
32020589-7	2020	PUFAs stimulated AMP activated protein kinase-alpha (AMPK-alpha) as well as peroxisome proliferator-activated receptor-alpha (PPAR-alpha).	Fatty Acids, Unsaturated	0-5	peroxisome proliferator activated receptor alpha	Mus musculus	126-136
32020589-10	2020	In conclusion, omega-3 and omega-6 PUFAs stimulate vascular differentiation of ES cells via mechanisms involving calcium, ROS and NO, which regulate function of the energy sensors AMPK and PPAR-alpha and determine the metabolic signature of vascular cell differentiation.	Fatty Acids, Unsaturated	35-40	peroxisome proliferator activated receptor alpha	Mus musculus	189-199
32755819-1	2020	Conjugated linoleic and linolenic acids (CLA and CLnA) can be found in dairy, ruminant meat and oilseeds, these types of unsaturated fatty acids consist of various positional and geometrical isomers, and have demonstrated health-promoting potential for human beings.	Fatty Acids, Unsaturated	121-144	selectin P ligand	Homo sapiens	41-44
32808658-2	2020	Eicosanoids are oxidised derivatives of 20-carbon polyunsaturated fatty acids (PUFAs) formed by the cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (cytP450) pathways.	Fatty Acids, Unsaturated	79-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	145-160
32808658-2	2020	Eicosanoids are oxidised derivatives of 20-carbon polyunsaturated fatty acids (PUFAs) formed by the cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (cytP450) pathways.	Fatty Acids, Unsaturated	79-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	162-169
32963690-8	2020	HO2   specifically reacts with the double bonds of polyunsaturated fatty acids (PUFA) initiating the isoprostane pathway of lipid peroxidation.	Fatty Acids, Unsaturated	51-78	heme oxygenase 2	Homo sapiens	0-3
32828309-1	2020	We evaluated the effect of gut bacterial metabolites of polyunsaturated fatty acids on inflammation and found that 10-oxo-cis-6,trans-11-octadecadienoic acid (gammaKetoC) strikingly suppressed LPS-induced IL-6 release from bone marrow-derived macrophages (BMMs), which was accompanied by reduced mRNA expression of Il6, TNF, and Il1b.	Fatty Acids, Unsaturated	56-83	suppressor of cytokine signaling 5	Homo sapiens	122-127
32963690-8	2020	HO2   specifically reacts with the double bonds of polyunsaturated fatty acids (PUFA) initiating the isoprostane pathway of lipid peroxidation.	Fatty Acids, Unsaturated	80-84	heme oxygenase 2	Homo sapiens	0-3
32588544-5	2020	RESULTS: Sortilin directs the uptake and conversion of polyunsaturated fatty acids into endocannabinoids, lipid-based neurotransmitters that act through nuclear receptors to sustain neuroprotective gene expression in the brain.	Fatty Acids, Unsaturated	55-82	sortilin 1	Mus musculus	9-17
32540644-1	2020	ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated fatty acid substrates to produce biologically active lipid mediators including eicosanes and lipoxins.	Fatty Acids, Unsaturated	71-97	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	0-6
32652311-1	2020	In contrast to other drug-metabolizing cytochrome P450 (CYP) oxygenases, CYP2J2 shows considerable extrahepatic activity and is responsible for the olefin epoxidation of several polyunsaturated fatty acid (PUFA) precursors.	Fatty Acids, Unsaturated	178-204	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	73-79
32652311-1	2020	In contrast to other drug-metabolizing cytochrome P450 (CYP) oxygenases, CYP2J2 shows considerable extrahepatic activity and is responsible for the olefin epoxidation of several polyunsaturated fatty acid (PUFA) precursors.	Fatty Acids, Unsaturated	206-210	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	73-79
32766764-2	2020	PPARgamma binds to DNA as a heterodimer with retinoid X receptor and it is activated by polyunsaturated fatty acids and fatty acid derivatives, such as prostaglandins.	Fatty Acids, Unsaturated	88-115	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
32824948-6	2020	These associations in NZ HF x J cross cows are novel, and they suggest that this variation in bovine MSTN could be explored for increasing the amount of milk unsaturated fatty acid and decreasing the amount of saturated fatty acid.	Fatty Acids, Unsaturated	158-180	myostatin	Bos taurus	101-105
32684465-7	2020	Specifically, various stronger positive correlations were noted for anthocyanin composition and UFA (pelargonidin and petunidin with C14:1n-5, C17:1n-7, C18:2n-6, C20:2n-6, C20:3n-3, and C20:4n-6; and cyanidin and total anthocyanins with C14:1n-5, C16:1n-7, C17:1n-7).	Fatty Acids, Unsaturated	96-99	cytokine like 1	Homo sapiens	143-146
32684465-7	2020	Specifically, various stronger positive correlations were noted for anthocyanin composition and UFA (pelargonidin and petunidin with C14:1n-5, C17:1n-7, C18:2n-6, C20:2n-6, C20:3n-3, and C20:4n-6; and cyanidin and total anthocyanins with C14:1n-5, C16:1n-7, C17:1n-7).	Fatty Acids, Unsaturated	96-99	Bardet-Biedl syndrome 9	Homo sapiens	153-156
32923723-8	2020	Nutritional status and diet contributed to the levels of IGFBP-1, demonstrated as an inverse correlation with maternal weight (Spearman r = -0.205, P = 0.04) and dietary intake of vitamin A (r = -0.253, P = 0.014) and a direct correlation with dietary intake of polyunsaturated fatty acids (Spearman r = 0.222, P = 0.03).	Fatty Acids, Unsaturated	262-289	insulin like growth factor binding protein 1	Homo sapiens	57-64
32891885-0	2020	Hepatic Levels of DHA-Containing Phospholipids Instruct SREBP1-Mediated Synthesis and Systemic Delivery of Polyunsaturated Fatty Acids.	Fatty Acids, Unsaturated	107-134	sterol regulatory element binding transcription factor 1	Homo sapiens	56-62
32251724-6	2020	Subcellular localization studies reveal that low UFAs cause a mislocalization of Aft1 protein to the vacuole upon iron deprivation that prevents its nuclear accumulation.	Fatty Acids, Unsaturated	49-53	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	81-85
32778150-1	2020	OBJECTIVE: The sulfur amino acid (SAA) cysteine is positively related, whereas polyunsaturated fatty acids (PUFAs) are inversely related to activity of the lipogenic enzyme stearoyl-CoA desaturase (SCD).	Fatty Acids, Unsaturated	79-106	stearoyl-CoA desaturase	Homo sapiens	173-196
32778150-1	2020	OBJECTIVE: The sulfur amino acid (SAA) cysteine is positively related, whereas polyunsaturated fatty acids (PUFAs) are inversely related to activity of the lipogenic enzyme stearoyl-CoA desaturase (SCD).	Fatty Acids, Unsaturated	108-113	stearoyl-CoA desaturase	Homo sapiens	173-196
32582958-8	2020	Supplementation of polyunsaturated fatty acids appeared to sensitize the PIEZO1-GFP response to applied pressure.	Fatty Acids, Unsaturated	19-46	piezo-type mechanosensitive ion channel component 1	Mus musculus	73-79
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Fatty Acids, Unsaturated	72-75	Mga2p	Saccharomyces cerevisiae S288C	28-32
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Fatty Acids, Unsaturated	72-75	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	37-41
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Fatty Acids, Unsaturated	72-75	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	96-100
32722083-1	2020	Polyunsaturated fatty acids of the n-3 series (n-3 PUFA) exhibit a number of favorable effects on the human organism and it is desirable to increase their intake in the diet.	Fatty Acids, Unsaturated	0-27	pumilio RNA binding family member 3	Homo sapiens	51-55
32732901-1	2020	omega-6 Polyunsaturated fatty acids (PUFAs) are essential fatty acids that participate in macroautophagy (hereafter referred to as autophagy) and the Kelch ECH-associating protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant system in organisms.	Fatty Acids, Unsaturated	37-42	kelch like ECH associated protein 1	Homo sapiens	150-181
32732901-1	2020	omega-6 Polyunsaturated fatty acids (PUFAs) are essential fatty acids that participate in macroautophagy (hereafter referred to as autophagy) and the Kelch ECH-associating protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant system in organisms.	Fatty Acids, Unsaturated	37-42	kelch like ECH associated protein 1	Homo sapiens	183-188
32732901-1	2020	omega-6 Polyunsaturated fatty acids (PUFAs) are essential fatty acids that participate in macroautophagy (hereafter referred to as autophagy) and the Kelch ECH-associating protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant system in organisms.	Fatty Acids, Unsaturated	37-42	NFE2 like bZIP transcription factor 2	Homo sapiens	190-233
32732901-1	2020	omega-6 Polyunsaturated fatty acids (PUFAs) are essential fatty acids that participate in macroautophagy (hereafter referred to as autophagy) and the Kelch ECH-associating protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant system in organisms.	Fatty Acids, Unsaturated	37-42	NFE2 like bZIP transcription factor 2	Homo sapiens	235-239
32731631-1	2020	Estimated Delta5-desaturase (D5D) and Delta6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified.	Fatty Acids, Unsaturated	95-122	fatty acid desaturase 1	Homo sapiens	10-27
32731631-1	2020	Estimated Delta5-desaturase (D5D) and Delta6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified.	Fatty Acids, Unsaturated	95-122	fatty acid desaturase 1	Homo sapiens	29-32
32731631-1	2020	Estimated Delta5-desaturase (D5D) and Delta6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified.	Fatty Acids, Unsaturated	95-122	fatty acid desaturase 2	Homo sapiens	38-55
32731631-1	2020	Estimated Delta5-desaturase (D5D) and Delta6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified.	Fatty Acids, Unsaturated	95-122	fatty acid desaturase 2	Homo sapiens	57-60
32731631-1	2020	Estimated Delta5-desaturase (D5D) and Delta6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified.	Fatty Acids, Unsaturated	124-128	fatty acid desaturase 1	Homo sapiens	10-27
32731631-1	2020	Estimated Delta5-desaturase (D5D) and Delta6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified.	Fatty Acids, Unsaturated	124-128	fatty acid desaturase 1	Homo sapiens	29-32
32731631-1	2020	Estimated Delta5-desaturase (D5D) and Delta6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified.	Fatty Acids, Unsaturated	124-128	fatty acid desaturase 2	Homo sapiens	38-55
32731631-1	2020	Estimated Delta5-desaturase (D5D) and Delta6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified.	Fatty Acids, Unsaturated	124-128	fatty acid desaturase 2	Homo sapiens	57-60
31943072-0	2020	Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.	Fatty Acids, Unsaturated	73-100	stearoyl-CoA desaturase	Homo sapiens	13-34
31943072-0	2020	Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.	Fatty Acids, Unsaturated	73-100	stearoyl-CoA desaturase	Homo sapiens	36-40
31943072-0	2020	Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.	Fatty Acids, Unsaturated	102-106	stearoyl-CoA desaturase	Homo sapiens	13-34
31943072-0	2020	Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.	Fatty Acids, Unsaturated	102-106	stearoyl-CoA desaturase	Homo sapiens	36-40
32698885-10	2020	However, n-3 polyunsaturated fatty acids (PUFAs) were inversely associated with CD8low but not CD8high cancers (CD8low ORT3 vs T1 = 0.45, 95% CI 0.23-0.87, Ptrend = 0.02; CD8high ORT3 vs T1 = 1.19, 95% CI 0.62-2.26, Ptrend = 0.62; Phet = 0.04).	Fatty Acids, Unsaturated	42-47	CD8a molecule	Homo sapiens	80-83
32501606-4	2020	A PUFA-deficient diet for over 5 weeks significantly reduced the sulfatide expression by increasing the sulfatide degradative enzymes arylsulfatase A and galactosylceramidase in brain and kidney.	Fatty Acids, Unsaturated	2-6	arylsulfatase A	Mus musculus	134-149
32686647-2	2020	Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and identify DECR1, encoding the rate-limiting enzyme for oxidation of polyunsaturated fatty acids (PUFAs), as robustly overexpressed in PCa tissues and associated with shorter relapse-free survival.	Fatty Acids, Unsaturated	175-202	2,4-dienoyl-CoA reductase 1	Homo sapiens	117-122
32686647-2	2020	Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and identify DECR1, encoding the rate-limiting enzyme for oxidation of polyunsaturated fatty acids (PUFAs), as robustly overexpressed in PCa tissues and associated with shorter relapse-free survival.	Fatty Acids, Unsaturated	204-209	2,4-dienoyl-CoA reductase 1	Homo sapiens	117-122
32686647-4	2020	DECR1 knockdown selectively inhibited beta-oxidation of PUFAs, inhibited proliferation and migration of PCa cells, including treatment resistant lines, and suppressed tumor cell proliferation and metastasis in mouse xenograft models.	Fatty Acids, Unsaturated	56-61	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	0-5
32294601-3	2020	We aimed to develop an analytical method to determine the production rates of polyunsaturated fatty acids (PUFAs), PUFA-oxylipin, and saturated-oxylipins by stimulated PBMCs and neutrophils based on solid phase extraction and HPLC-MS/MS technology.	Fatty Acids, Unsaturated	78-105	pumilio RNA binding family member 3	Homo sapiens	107-111
32632088-3	2020	Here, we hypothesized that GPR40 (FFAR1), the receptor for medium and long chain unsaturated fatty acids, could mediate at least part of the neurogenic activity in the hypothalamus.	Fatty Acids, Unsaturated	81-104	free fatty acid receptor 1	Mus musculus	27-32
32632088-3	2020	Here, we hypothesized that GPR40 (FFAR1), the receptor for medium and long chain unsaturated fatty acids, could mediate at least part of the neurogenic activity in the hypothalamus.	Fatty Acids, Unsaturated	81-104	free fatty acid receptor 1	Mus musculus	34-39
32727647-0	2020	[Unsaturated fatty acid of Actinidia chinesis planch seed oil (kiwi fruit essence) inhibits growth and metastasis of transplanted tumor in lung adenocarcinoma mice by up-regulating EHD2 expression].	Fatty Acids, Unsaturated	1-23	EH-domain containing 2	Mus musculus	181-185
31991038-5	2020	AtROD1 encodes phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT), the enzyme that catalyzes a major flux of polyunsaturated fatty acids (PUFA) in oil synthesis.	Fatty Acids, Unsaturated	126-153	phosphatidic acid phosphatase-related / PAP2-like protein	Arabidopsis thaliana	0-6
31991038-5	2020	AtROD1 encodes phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT), the enzyme that catalyzes a major flux of polyunsaturated fatty acids (PUFA) in oil synthesis.	Fatty Acids, Unsaturated	155-159	phosphatidic acid phosphatase-related / PAP2-like protein	Arabidopsis thaliana	0-6
31991038-8	2020	These results indicate that ROD1 isozymes in canola are responsible for less than 20% of the PUFA that accumulate in the seed oil, compared with 40% in Arabidopsis.	Fatty Acids, Unsaturated	93-97	phosphatidic acid phosphatase-related / PAP2-like protein	Arabidopsis thaliana	28-32
32727647-1	2020	Objective To observe the role of Eps15 homology domain containing protein 2 (EHD2) in the inhibitive effects of unsaturated fatty acid of Actinidia chinesis planch seed oil (kiwi fruit essence) on the growth and metastasis of transplanted tumor in lung adenocarcinoma mice.	Fatty Acids, Unsaturated	112-134	epidermal growth factor receptor pathway substrate 15	Mus musculus	33-38
32727647-1	2020	Objective To observe the role of Eps15 homology domain containing protein 2 (EHD2) in the inhibitive effects of unsaturated fatty acid of Actinidia chinesis planch seed oil (kiwi fruit essence) on the growth and metastasis of transplanted tumor in lung adenocarcinoma mice.	Fatty Acids, Unsaturated	112-134	EH-domain containing 2	Mus musculus	77-81
32553105-0	2020	Correction: Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms.	Fatty Acids, Unsaturated	12-38	caveolin 2	Homo sapiens	84-87
32676090-1	2020	Fatty Acid Desaturase 7 (FAD7) generates polyunsaturated fatty acids, promoting the desaturation of chloroplast membranes; it also provides an essential precursor for the synthesis of jasmonic acid (JA), a phytohormone that can influence plant growth, development, and primary metabolism.	Fatty Acids, Unsaturated	41-68	omega-3 fatty acid desaturase	Solanum lycopersicum	0-23
32676090-1	2020	Fatty Acid Desaturase 7 (FAD7) generates polyunsaturated fatty acids, promoting the desaturation of chloroplast membranes; it also provides an essential precursor for the synthesis of jasmonic acid (JA), a phytohormone that can influence plant growth, development, and primary metabolism.	Fatty Acids, Unsaturated	41-68	omega-3 fatty acid desaturase	Solanum lycopersicum	25-29
32521814-4	2020	Saturated fatty acid and polyunsaturated fatty acid content significantly decreased with pressure increase from 200 to 600 MPa for shank and shoulder cuts, and 300 to 600 MPa for loin cut.	Fatty Acids, Unsaturated	25-51	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	131-136
32487758-5	2020	Here, we have investigated the function of one of these enzymes, a putative 2,4-dienoyl-coenzyme A (CoA) reductase (DECR), which is specifically required for the beta-oxidation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	180-207	2,4-dienoyl-CoA reductase 1	Homo sapiens	116-120
31899373-5	2020	PUFA epoxides are, however, further metabolized by the soluble epoxide hydrolase (sEH) to fatty acid diols.	Fatty Acids, Unsaturated	0-4	epoxide hydrolase 2	Homo sapiens	55-80
32339103-1	2020	BACKGROUND: Soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids might play a role in the pathogenesis of major psychiatric disorders.	Fatty Acids, Unsaturated	65-92	epoxide hydrolase 2	Homo sapiens	12-37
32339103-1	2020	BACKGROUND: Soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids might play a role in the pathogenesis of major psychiatric disorders.	Fatty Acids, Unsaturated	65-92	epoxide hydrolase 2	Homo sapiens	39-42
32186652-0	2020	Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.	Fatty Acids, Unsaturated	42-69	fatty acid desaturase 1	Homo sapiens	15-22
32452400-1	2020	The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP).	Fatty Acids, Unsaturated	45-72	stearoyl-CoA desaturase	Homo sapiens	106-127
32475074-5	2020	In particular, the levels of two omega-6 polyunsaturated fatty acids (PUFAs), linoleic acid and arachidonic acid, were increased by knockdown of lpin-1 but decreased by glucose feeding.	Fatty Acids, Unsaturated	70-75	LNS2 domain-containing protein	Caenorhabditis elegans	145-151
31899373-5	2020	PUFA epoxides are, however, further metabolized by the soluble epoxide hydrolase (sEH) to fatty acid diols.	Fatty Acids, Unsaturated	0-4	epoxide hydrolase 2	Homo sapiens	82-85
32398692-0	2020	Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression.	Fatty Acids, Unsaturated	70-96	aryl-hydrocarbon receptor	Mus musculus	0-25
32486008-8	2020	Our results showed that unsaturated FAs, especially long-chain unsaturated FAs, inhibited URAT1 more strongly than saturated FAs.	Fatty Acids, Unsaturated	24-39	solute carrier family 22 member 12	Homo sapiens	90-95
32486008-8	2020	Our results showed that unsaturated FAs, especially long-chain unsaturated FAs, inhibited URAT1 more strongly than saturated FAs.	Fatty Acids, Unsaturated	63-78	solute carrier family 22 member 12	Homo sapiens	90-95
32944623-3	2020	Mechanistically, AMPK regulates ferroptosis through acetyl-CoA carboxylase (ACC) and polyunsaturated fatty acid (PUFA) biosynthesis.	Fatty Acids, Unsaturated	85-111	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	17-21
32944623-3	2020	Mechanistically, AMPK regulates ferroptosis through acetyl-CoA carboxylase (ACC) and polyunsaturated fatty acid (PUFA) biosynthesis.	Fatty Acids, Unsaturated	113-117	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	17-21
32398374-3	2020	Soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids is shown to play a key role in the development of ASD in offspring after maternal immune activation.	Fatty Acids, Unsaturated	53-80	epoxide hydrolase 2	Homo sapiens	0-25
32398374-3	2020	Soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids is shown to play a key role in the development of ASD in offspring after maternal immune activation.	Fatty Acids, Unsaturated	53-80	epoxide hydrolase 2	Homo sapiens	27-30
32329491-6	2020	The results showed that polyunsaturated fatty acids (PUFA) and PUFA acyl-phospholipids (PFA-PLs) were down-regulated and the levels of saturated fatty acyl-phospholipids (SFA-PLs) and EAs were up-regulated in both the liver tissue and plasma of the CCl4-injury group.	Fatty Acids, Unsaturated	53-57	chemokine (C-C motif) ligand 4	Mus musculus	249-253
32398692-5	2020	These responses were likely attributable to the corresponding PUFA epoxides generated in tumor cells and/or host, since many depended upon co-administration of a soluble epoxide hydrolase (EPHX2) inhibitor in males, and/or were associated with increases in epoxide levels in tumors and sites of metastasis.	Fatty Acids, Unsaturated	62-66	epoxide hydrolase 2, cytoplasmic	Mus musculus	189-194
32398692-2	2020	The prototypical aryl hydrocarbon receptor (AHR) ligand, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), induces CYP1 family enzymes, which can metabolize PUFA to epoxides.	Fatty Acids, Unsaturated	151-155	aryl-hydrocarbon receptor	Mus musculus	17-42
32398692-2	2020	The prototypical aryl hydrocarbon receptor (AHR) ligand, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), induces CYP1 family enzymes, which can metabolize PUFA to epoxides.	Fatty Acids, Unsaturated	151-155	aryl-hydrocarbon receptor	Mus musculus	44-47
32332698-2	2020	Fatty acid desaturase 1 (FADS1), as the key rate-limiting enzyme of polyunsaturated fatty acids (PUFAs), catalyzes dihomo-gamma-linolenic acid (DGLA) to arachidonic acid (AA).	Fatty Acids, Unsaturated	68-95	fatty acid desaturase 1	Homo sapiens	0-23
31753522-1	2020	OBJECTIVE: Oxylipins are biologically active signaling molecules that initiate and resolve inflammation; they are synthesized by oxidation of polyunsaturated fatty acids (PUFAs) and reflect PUFA intake and status.	Fatty Acids, Unsaturated	142-169	pumilio RNA binding family member 3	Homo sapiens	171-175
32332698-2	2020	Fatty acid desaturase 1 (FADS1), as the key rate-limiting enzyme of polyunsaturated fatty acids (PUFAs), catalyzes dihomo-gamma-linolenic acid (DGLA) to arachidonic acid (AA).	Fatty Acids, Unsaturated	68-95	fatty acid desaturase 1	Homo sapiens	25-30
32332698-2	2020	Fatty acid desaturase 1 (FADS1), as the key rate-limiting enzyme of polyunsaturated fatty acids (PUFAs), catalyzes dihomo-gamma-linolenic acid (DGLA) to arachidonic acid (AA).	Fatty Acids, Unsaturated	97-102	fatty acid desaturase 1	Homo sapiens	0-23
32332698-2	2020	Fatty acid desaturase 1 (FADS1), as the key rate-limiting enzyme of polyunsaturated fatty acids (PUFAs), catalyzes dihomo-gamma-linolenic acid (DGLA) to arachidonic acid (AA).	Fatty Acids, Unsaturated	97-102	fatty acid desaturase 1	Homo sapiens	25-30
32316553-5	2020	Distributions of two monounsaturated fatty acids and three polyunsaturated fatty acids were observed in the human lip tissue: palmitoleic acid (POA) and oleic acid (OA) and linoleic acid (LA), arachidonic acid (AA), and docosahexaenoic acid (DHA), respectively.	Fatty Acids, Unsaturated	59-86	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	114-117
32161117-2	2020	However, recent work has demonstrated that the major phospholipase in mitochondria, iPLA2gamma (patatin-like phospholipase domain containing 8 (PNPLA8)), possesses sn-1 specificity, with polyunsaturated fatty acids at the sn-2 position generating polyunsaturated sn-2-acyl lysophospholipids.	Fatty Acids, Unsaturated	187-214	patatin like phospholipase domain containing 8	Homo sapiens	84-94
32161117-2	2020	However, recent work has demonstrated that the major phospholipase in mitochondria, iPLA2gamma (patatin-like phospholipase domain containing 8 (PNPLA8)), possesses sn-1 specificity, with polyunsaturated fatty acids at the sn-2 position generating polyunsaturated sn-2-acyl lysophospholipids.	Fatty Acids, Unsaturated	187-214	patatin-like phospholipase domain containing 8	Mus musculus	96-142
32290535-4	2020	Also, recent studies in either experimental animal models or in humans, have shown encouraging results for insulin-sensitizing nutritional supplements derived from MedDiet food sources in the modulation of pathognomonic traits of certain IR-related conditions, including polyunsaturated fatty acids from olive oil and seeds, anthocyanins from purple vegetables and fruits, resveratrol from grapes, and the EVOO-derived, oleacein.	Fatty Acids, Unsaturated	271-298	insulin	Homo sapiens	107-114
32161117-2	2020	However, recent work has demonstrated that the major phospholipase in mitochondria, iPLA2gamma (patatin-like phospholipase domain containing 8 (PNPLA8)), possesses sn-1 specificity, with polyunsaturated fatty acids at the sn-2 position generating polyunsaturated sn-2-acyl lysophospholipids.	Fatty Acids, Unsaturated	187-214	patatin-like phospholipase domain containing 8	Mus musculus	144-150
32071081-9	2020	Metabolic labeling with alkyne-oleic acid (100 muM for 15 h) revealed that oleic acid attaches to ASBT, suggesting that unsaturated fatty acids may decrease ASBT"s function via a direct covalent interaction with ASBT.	Fatty Acids, Unsaturated	120-143	solute carrier family 10 member 2	Homo sapiens	98-102
32054635-5	2020	Because GstS1 is a fly ortholog of mammalian hematopoietic prostaglandin D synthase, and in mammals CYPs are involved in the oxygenation of polyunsaturated fatty acids including prostaglandins, our results raise the intriguing possibility that bioactive lipids play a role in GstS1-mediated suppression of paraShu phenotypes.	Fatty Acids, Unsaturated	140-167	Glutathione S transferase S1	Drosophila melanogaster	8-13
32071081-9	2020	Metabolic labeling with alkyne-oleic acid (100 muM for 15 h) revealed that oleic acid attaches to ASBT, suggesting that unsaturated fatty acids may decrease ASBT"s function via a direct covalent interaction with ASBT.	Fatty Acids, Unsaturated	120-143	solute carrier family 10 member 2	Homo sapiens	157-161
32071081-9	2020	Metabolic labeling with alkyne-oleic acid (100 muM for 15 h) revealed that oleic acid attaches to ASBT, suggesting that unsaturated fatty acids may decrease ASBT"s function via a direct covalent interaction with ASBT.	Fatty Acids, Unsaturated	120-143	solute carrier family 10 member 2	Homo sapiens	157-161
32215565-9	2020	Dietary manipulation of the lactating sow influences the transfer of the n-3 and n-6 polyunsaturated fatty acids (PUFA) from the sow milk to the piglet and the incorporation of the FA into piglet enteric tissues and cell membranes, which exerts bioactivity of importance for immune responses and the epithelial barrier function.	Fatty Acids, Unsaturated	114-118	Polyunsaturated fatty acid percentage	Sus scrofa	85-112
31248967-1	2020	Glutathione peroxidase 4 (GPX4) is unique as it is the only enzyme that can prevent detrimental lipid peroxidation in vivo by reducing lipid peroxides to the respective alcohols thereby stabilizing oxidation products of unsaturated fatty acids.	Fatty Acids, Unsaturated	220-243	glutathione peroxidase 4	Mus musculus	0-24
31248967-1	2020	Glutathione peroxidase 4 (GPX4) is unique as it is the only enzyme that can prevent detrimental lipid peroxidation in vivo by reducing lipid peroxides to the respective alcohols thereby stabilizing oxidation products of unsaturated fatty acids.	Fatty Acids, Unsaturated	220-243	glutathione peroxidase 4	Mus musculus	26-30
32241511-9	2020	The yolks in the eggs from hens receiving the APC addition were characterized by distinctly higher content of polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	110-137	APC, WNT signaling pathway regulator	Gallus gallus	46-49
32146252-4	2020	3T3-L1 pre- and mature adipocytes were found to express Ang-1, Ang-2, and Tie-2, which decrease upon polyunsaturated fatty acid treatment.	Fatty Acids, Unsaturated	101-127	angiopoietin 1	Mus musculus	56-61
32146252-4	2020	3T3-L1 pre- and mature adipocytes were found to express Ang-1, Ang-2, and Tie-2, which decrease upon polyunsaturated fatty acid treatment.	Fatty Acids, Unsaturated	101-127	angiogenin, ribonuclease A family, member 2	Mus musculus	63-68
32146252-4	2020	3T3-L1 pre- and mature adipocytes were found to express Ang-1, Ang-2, and Tie-2, which decrease upon polyunsaturated fatty acid treatment.	Fatty Acids, Unsaturated	101-127	TEK receptor tyrosine kinase	Mus musculus	74-79
31733338-5	2020	Members of omega-3 as well as omega-6 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid and arachidonic acid, respectively, can be metabolized by CYP isoforms leading to the production of biologically active lipid mediators called eicosanoids.	Fatty Acids, Unsaturated	30-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	162-165
32044546-3	2020	In particular, omega-3 polyunsaturated fatty acids are able to activate nuclear factor erythroid 2-related factor 2 (Nrf-2) to prevent diabetes mellitus-related complications by mitigating oxidative stress.	Fatty Acids, Unsaturated	15-50	NFE2 like bZIP transcription factor 2	Rattus norvegicus	72-115
32044546-3	2020	In particular, omega-3 polyunsaturated fatty acids are able to activate nuclear factor erythroid 2-related factor 2 (Nrf-2) to prevent diabetes mellitus-related complications by mitigating oxidative stress.	Fatty Acids, Unsaturated	15-50	NFE2 like bZIP transcription factor 2	Homo sapiens	117-122
32126480-7	2020	Lower (10 muM) and higher (50 muM) exogenous PUFA concentrations also had different impacts on the expression of PUFA metabolizing enzymes.	Fatty Acids, Unsaturated	45-49	latexin	Homo sapiens	10-13
32126480-7	2020	Lower (10 muM) and higher (50 muM) exogenous PUFA concentrations also had different impacts on the expression of PUFA metabolizing enzymes.	Fatty Acids, Unsaturated	45-49	latexin	Homo sapiens	30-33
32224946-7	2020	On the other hand, long chain fatty acids (LCFA) were more abundant in P and A cheeses than in S. In general, MUFA, PUFA and, consequently, total unsaturated FA (UFA), were significantly higher in the P and A cheeses than S (UFA: 36.55 and 38.34, respectively, vs 31.13; p < 0.001), while SFA showed higher values in S (68.85 vs 63.41 and 61.68 in P and A, respectively; p < 0.001).	Fatty Acids, Unsaturated	117-120	MUFA	Bos taurus	110-114
32207683-0	2020	Polyunsaturated fatty acid analogues differentially affect cardiac Nav, Cav, and Kv channels through unique mechanisms.	Fatty Acids, Unsaturated	0-26	caveolin 2	Homo sapiens	72-75
32214349-12	2020	Our findings indicated that binding of unsaturated fatty acids to Calprotectin leads to structural changes of the S100A8/A9 subunits which could be beneficial to play a biological role in inflammation process.	Fatty Acids, Unsaturated	39-62	S100 calcium binding protein A8	Homo sapiens	114-123
31991095-0	2020	DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in Macrophages.	Fatty Acids, Unsaturated	25-29	diacylglycerol lipase beta	Homo sapiens	0-9
32198481-5	2020	hNM dynamics was determined by solid-state NMR and revealed that the lamellar gel-to-fluid phase transition occurs below 0  C, reflecting the presence of elevated amounts of unsaturated fatty acid chains.	Fatty Acids, Unsaturated	174-196	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
31991095-1	2020	Here, we apply quantitative chemical proteomics and untargeted lipidomics to assign a polyunsaturated fatty acid (PUFA)-specific triacylglycerol (TAG) lipase activity for diacylglycerol lipase-beta (DAGLbeta) in macrophages.	Fatty Acids, Unsaturated	86-112	diacylglycerol lipase beta	Homo sapiens	171-197
31991095-1	2020	Here, we apply quantitative chemical proteomics and untargeted lipidomics to assign a polyunsaturated fatty acid (PUFA)-specific triacylglycerol (TAG) lipase activity for diacylglycerol lipase-beta (DAGLbeta) in macrophages.	Fatty Acids, Unsaturated	86-112	diacylglycerol lipase alpha	Homo sapiens	199-207
31991095-1	2020	Here, we apply quantitative chemical proteomics and untargeted lipidomics to assign a polyunsaturated fatty acid (PUFA)-specific triacylglycerol (TAG) lipase activity for diacylglycerol lipase-beta (DAGLbeta) in macrophages.	Fatty Acids, Unsaturated	114-118	diacylglycerol lipase beta	Homo sapiens	171-197
31991095-1	2020	Here, we apply quantitative chemical proteomics and untargeted lipidomics to assign a polyunsaturated fatty acid (PUFA)-specific triacylglycerol (TAG) lipase activity for diacylglycerol lipase-beta (DAGLbeta) in macrophages.	Fatty Acids, Unsaturated	114-118	diacylglycerol lipase alpha	Homo sapiens	199-207
31991095-3	2020	Genetic disruption of DAGLbeta resulted in accumulation of cellular TAGs composed of PUFA but not saturated/low unsaturated fatty acid counterparts, which is recapitulated in wild-type macrophages treated with a DAGLbeta-selective inhibitor.	Fatty Acids, Unsaturated	85-89	diacylglycerol lipase alpha	Homo sapiens	22-30
31991095-3	2020	Genetic disruption of DAGLbeta resulted in accumulation of cellular TAGs composed of PUFA but not saturated/low unsaturated fatty acid counterparts, which is recapitulated in wild-type macrophages treated with a DAGLbeta-selective inhibitor.	Fatty Acids, Unsaturated	112-134	diacylglycerol lipase alpha	Homo sapiens	22-30
31991095-4	2020	Biochemical assays with synthetic substrates confirm PUFA-TAGs as authentic DAGLbeta substrates.	Fatty Acids, Unsaturated	53-57	diacylglycerol lipase alpha	Homo sapiens	76-84
31991095-5	2020	In summary, our findings identify DAGLbeta as a PUFA-specific TAG lipase in primary macrophages.	Fatty Acids, Unsaturated	48-52	diacylglycerol lipase alpha	Homo sapiens	34-42
32182938-3	2020	Sorafenib might affect epoxyeicosanoids, as it is also a potent inhibitor of the soluble epoxide hydrolase (sEH), which catalyzes the conversion of epoxides derived from long-chain polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA) and omega-3 docosahexaenoic acid (DHA), into their corresponding diols.	Fatty Acids, Unsaturated	210-215	epoxide hydrolase 2	Homo sapiens	81-106
31831363-1	2020	BACKGROUND AND AIMS: Omega-3 polyunsaturated fatty acids (PUFAs) are natural peroxisome proliferator-activated receptor gamma (PPAR-gamma) ligands.	Fatty Acids, Unsaturated	58-63	peroxisome proliferator activated receptor gamma	Homo sapiens	77-125
32182938-3	2020	Sorafenib might affect epoxyeicosanoids, as it is also a potent inhibitor of the soluble epoxide hydrolase (sEH), which catalyzes the conversion of epoxides derived from long-chain polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA) and omega-3 docosahexaenoic acid (DHA), into their corresponding diols.	Fatty Acids, Unsaturated	210-215	epoxide hydrolase 2	Homo sapiens	108-111
31831363-1	2020	BACKGROUND AND AIMS: Omega-3 polyunsaturated fatty acids (PUFAs) are natural peroxisome proliferator-activated receptor gamma (PPAR-gamma) ligands.	Fatty Acids, Unsaturated	58-63	peroxisome proliferator activated receptor gamma	Homo sapiens	127-137
31751799-3	2020	Fatty acid desaturase 2 (FADS2) codes for a multifunctional enzyme that catalyzes Delta4-, Delta6- and Delta8-desaturation towards ten unsaturated fatty acids but only one saturate, palmitic acid, converting it to 16:1n-10; FADS2 is not active towards 14:0 or 18:0.	Fatty Acids, Unsaturated	135-158	fatty acid desaturase 2	Homo sapiens	25-30
31996026-8	2020	The effect of miR-210 was due to targeting 2,4-dienoyl-CoA reductase, which is essential in the beta oxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	114-137	microRNA 210	Mus musculus	14-21
31751799-3	2020	Fatty acid desaturase 2 (FADS2) codes for a multifunctional enzyme that catalyzes Delta4-, Delta6- and Delta8-desaturation towards ten unsaturated fatty acids but only one saturate, palmitic acid, converting it to 16:1n-10; FADS2 is not active towards 14:0 or 18:0.	Fatty Acids, Unsaturated	135-158	delta like canonical Notch ligand 4	Homo sapiens	97-103
31751799-3	2020	Fatty acid desaturase 2 (FADS2) codes for a multifunctional enzyme that catalyzes Delta4-, Delta6- and Delta8-desaturation towards ten unsaturated fatty acids but only one saturate, palmitic acid, converting it to 16:1n-10; FADS2 is not active towards 14:0 or 18:0.	Fatty Acids, Unsaturated	135-158	fatty acid desaturase 2	Homo sapiens	0-23
31751799-3	2020	Fatty acid desaturase 2 (FADS2) codes for a multifunctional enzyme that catalyzes Delta4-, Delta6- and Delta8-desaturation towards ten unsaturated fatty acids but only one saturate, palmitic acid, converting it to 16:1n-10; FADS2 is not active towards 14:0 or 18:0.	Fatty Acids, Unsaturated	135-158	fatty acid desaturase 2	Homo sapiens	224-229
32042421-1	2020	The interaction between human serum albumin (HSA) and arachidonic acid (AA) as an unsaturated fatty acid were investigated in the present study using methods including UV-VIS spectrophotometry, fluorescence and circular dichroism (CD) spectroscopy, lifetime measurements, fluorescence anisotropy measurements and visual molecular dynamics (MD).	Fatty Acids, Unsaturated	82-104	albumin	Homo sapiens	30-43
32042421-1	2020	The interaction between human serum albumin (HSA) and arachidonic acid (AA) as an unsaturated fatty acid were investigated in the present study using methods including UV-VIS spectrophotometry, fluorescence and circular dichroism (CD) spectroscopy, lifetime measurements, fluorescence anisotropy measurements and visual molecular dynamics (MD).	Fatty Acids, Unsaturated	82-104	albumin	Homo sapiens	45-48
32062066-1	2020	Cyclooxygenase-2 and several lipoxygenases convert polyunsaturated fatty acids into a large variety of products.	Fatty Acids, Unsaturated	51-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
31132459-6	2020	Interestingly, supplementing with fish oil which is rich in omega-3 polyunsaturated fatty acids (PUFAs) significantly enhanced the expression level of LRP-1 and promoted Abeta clearance from the bran to circulation, as revealed by reduced soluble/insoluble Abeta levels and senile plaques in the brain parenchyma and a corresponding increase of Abeta levels in plasma.	Fatty Acids, Unsaturated	97-102	low density lipoprotein receptor-related protein 1	Mus musculus	151-156
31433904-2	2020	Some studies have reported an association between self-reported intake of n-3 polyunsaturated fatty acids (PUFAs) and serum resistin levels.	Fatty Acids, Unsaturated	107-112	resistin	Homo sapiens	124-132
32001573-0	2020	Correction to "A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid omega-1 Hydroxylation Using an Untargeted Metabolomic Approach".	Fatty Acids, Unsaturated	66-92	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	43-62
32006211-4	2020	Furthermore, work from our group suggests that the combined effects of butyrate and omega-3 polyunsaturated fatty acids (n-3 PUFA) may enhance the chemopreventive potential of these dietary constituents.	Fatty Acids, Unsaturated	84-119	pumilio RNA binding family member 3	Homo sapiens	125-129
32074977-1	2020	We investigated changes in functional fitness after an exercise program in combination with Calanus oil supplementation, a novel source of bioactive lipids rich in wax esters with omega-3 polyunsaturated fatty acid (n-3 PUFA).	Fatty Acids, Unsaturated	180-214	pumilio RNA binding family member 3	Homo sapiens	220-224
31928966-0	2020	rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression.	Fatty Acids, Unsaturated	19-45	ELOVL fatty acid elongase 2	Homo sapiens	71-77
31882213-6	2020	Adding SCD1 genotypes to the milk IR spectra resulted in a considerable improvement of the prediction accuracy for the unsaturated fatty acids C10:1, C12:1, C14:1 cis-9, and C16:1 cis-9 and their corresponding unsaturation indices.	Fatty Acids, Unsaturated	119-142	stearoyl-CoA desaturase	Bos taurus	7-11
32046209-6	2020	Fat-1 expression down-regulated the genes related to the cell cycle; the NF-kappaB signaling pathway and the PI3K/Akt signaling pathway were down-regulated, and the PUFAs (polyunsaturated fatty acids) biosynthesis pathway was shifted toward the biosynthesis of high-level n-3 LC-PUFAs (long-chain PUFAs).	Fatty Acids, Unsaturated	165-170	protocadherin Fat 1	Ovis aries	0-5
32052201-2	2020	It can manifest in the aqueous humor (AH) and tear fluid (TF) as alterations in polyunsaturated fatty acids (PUFAs) and their metabolites, oxylipins, lipid mediators, which are biosynthesized via enzymatic pathways involving lipoxygenase, cyclooxygenase or cytochrome P450 monooxygenase and specifically regulate inflammation and resolution pathways.	Fatty Acids, Unsaturated	80-107	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	257-286
32046209-7	2020	Four key node genes, FADS2, PPARA, PRKACA, and ACACA, were found to be responsible for the gene expression profile shift from the Fat-1 transgenic 100-day fetus to postnatal lamb, and FADS2 may play a key role in the accumulation of n-3 LC-PUFAs in Fat-1 transgenic sheep muscle.	Fatty Acids, Unsaturated	240-245	acyl-CoA 6-desaturase	Ovis aries	21-26
32046209-6	2020	Fat-1 expression down-regulated the genes related to the cell cycle; the NF-kappaB signaling pathway and the PI3K/Akt signaling pathway were down-regulated, and the PUFAs (polyunsaturated fatty acids) biosynthesis pathway was shifted toward the biosynthesis of high-level n-3 LC-PUFAs (long-chain PUFAs).	Fatty Acids, Unsaturated	172-199	protocadherin Fat 1	Ovis aries	0-5
32046209-6	2020	Fat-1 expression down-regulated the genes related to the cell cycle; the NF-kappaB signaling pathway and the PI3K/Akt signaling pathway were down-regulated, and the PUFAs (polyunsaturated fatty acids) biosynthesis pathway was shifted toward the biosynthesis of high-level n-3 LC-PUFAs (long-chain PUFAs).	Fatty Acids, Unsaturated	279-284	protocadherin Fat 1	Ovis aries	0-5
32046209-7	2020	Four key node genes, FADS2, PPARA, PRKACA, and ACACA, were found to be responsible for the gene expression profile shift from the Fat-1 transgenic 100-day fetus to postnatal lamb, and FADS2 may play a key role in the accumulation of n-3 LC-PUFAs in Fat-1 transgenic sheep muscle.	Fatty Acids, Unsaturated	240-245	PPARA	Ovis aries	28-33
32046209-6	2020	Fat-1 expression down-regulated the genes related to the cell cycle; the NF-kappaB signaling pathway and the PI3K/Akt signaling pathway were down-regulated, and the PUFAs (polyunsaturated fatty acids) biosynthesis pathway was shifted toward the biosynthesis of high-level n-3 LC-PUFAs (long-chain PUFAs).	Fatty Acids, Unsaturated	279-284	protocadherin Fat 1	Ovis aries	0-5
32046209-7	2020	Four key node genes, FADS2, PPARA, PRKACA, and ACACA, were found to be responsible for the gene expression profile shift from the Fat-1 transgenic 100-day fetus to postnatal lamb, and FADS2 may play a key role in the accumulation of n-3 LC-PUFAs in Fat-1 transgenic sheep muscle.	Fatty Acids, Unsaturated	240-245	acetyl-CoA carboxylase 1	Ovis aries	47-52
32046209-7	2020	Four key node genes, FADS2, PPARA, PRKACA, and ACACA, were found to be responsible for the gene expression profile shift from the Fat-1 transgenic 100-day fetus to postnatal lamb, and FADS2 may play a key role in the accumulation of n-3 LC-PUFAs in Fat-1 transgenic sheep muscle.	Fatty Acids, Unsaturated	240-245	protocadherin Fat 1	Ovis aries	130-135
32046209-7	2020	Four key node genes, FADS2, PPARA, PRKACA, and ACACA, were found to be responsible for the gene expression profile shift from the Fat-1 transgenic 100-day fetus to postnatal lamb, and FADS2 may play a key role in the accumulation of n-3 LC-PUFAs in Fat-1 transgenic sheep muscle.	Fatty Acids, Unsaturated	240-245	acyl-CoA 6-desaturase	Ovis aries	184-189
31678511-7	2020	We further demonstrate that reduced production of unsaturated fatty acids (FAs) by blocking SCD-1 activity is beneficial for the anti-invasion effect of TCN.	Fatty Acids, Unsaturated	50-73	stearoyl-CoA desaturase	Homo sapiens	92-97
31989025-3	2020	Synthesis of BH4/BH2 by GCH1-expressing cells caused lipid remodeling, suppressing ferroptosis by selectively preventing depletion of phospholipids with two polyunsaturated fatty acyl tails.	Fatty Acids, Unsaturated	157-183	GTP cyclohydrolase 1	Homo sapiens	24-28
31943697-1	2020	Methylation of the regulatory region of the elongation of very-long-chain fatty acids-like 2 (ELOVL2) gene, an enzyme involved in elongation of long-chain polyunsaturated fatty acids, is one of the most robust biomarkers of human age, but the critical question of whether ELOVL2 plays a functional role in molecular aging has not been resolved.	Fatty Acids, Unsaturated	155-182	ELOVL fatty acid elongase 2	Homo sapiens	44-92
31943697-1	2020	Methylation of the regulatory region of the elongation of very-long-chain fatty acids-like 2 (ELOVL2) gene, an enzyme involved in elongation of long-chain polyunsaturated fatty acids, is one of the most robust biomarkers of human age, but the critical question of whether ELOVL2 plays a functional role in molecular aging has not been resolved.	Fatty Acids, Unsaturated	155-182	ELOVL fatty acid elongase 2	Homo sapiens	94-100
31943697-1	2020	Methylation of the regulatory region of the elongation of very-long-chain fatty acids-like 2 (ELOVL2) gene, an enzyme involved in elongation of long-chain polyunsaturated fatty acids, is one of the most robust biomarkers of human age, but the critical question of whether ELOVL2 plays a functional role in molecular aging has not been resolved.	Fatty Acids, Unsaturated	155-182	ELOVL fatty acid elongase 2	Homo sapiens	272-278
31943697-7	2020	These findings indicate that ELOVL2 activity regulates aging in mouse retina, provide a molecular link between polyunsaturated fatty acids elongation and visual function, and suggest novel therapeutic strategies for the treatment of age-related eye diseases.	Fatty Acids, Unsaturated	111-138	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	Mus musculus	29-35
31988297-4	2020	Liquid chromatograph time-of-flight mass spectrometry-based metabolome analysis demonstrated that the content of unsaturated fatty acids was increased in MYCN high expression (MYCNhigh) CSC-like HCC cells.	Fatty Acids, Unsaturated	113-136	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	154-158
31676440-5	2020	In comparison with wild type worms, animals lacking LIPL-5 were enriched in cardiolipins linked to polyunsaturated C20 fatty acids and coenzyme Q-9.	Fatty Acids, Unsaturated	99-130	Lipase lipl-5	Caenorhabditis elegans	52-58
31913753-7	2020	The increases in some unsaturated fatty acids are probably related to the upregulation of stearoyl-coenzyme A desaturase-1 and fatty acid desaturase-1.	Fatty Acids, Unsaturated	22-45	stearoyl-CoA desaturase	Rattus norvegicus	90-150
32029897-6	2020	Functional and lipidomic analyses further link AMPK regulation of ferroptosis to AMPK-mediated phosphorylation of acetyl-CoA carboxylase and polyunsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	141-167	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	47-51
32029897-6	2020	Functional and lipidomic analyses further link AMPK regulation of ferroptosis to AMPK-mediated phosphorylation of acetyl-CoA carboxylase and polyunsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	141-167	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	81-85
31989025-5	2020	The GCH1-BH4-phospholipid axis acts as a master regulator of ferroptosis resistance, controlling endogenous production of the antioxidant BH4, abundance of CoQ10, and peroxidation of unusual phospholipids with two polyunsaturated fatty acyl tails.	Fatty Acids, Unsaturated	214-240	GTP cyclohydrolase 1	Homo sapiens	4-8
31963810-6	2020	Milk from cows grazing chicory contained greater concentrations of polyunsaturated FA (PUFA) such as C18:3 c9, 12, 15 and C18:2 c9, 12 than those on RGWC.	Fatty Acids, Unsaturated	67-85	Weaning weight-maternal milk	Bos taurus	0-4
32064024-5	2020	Moreover, the TLR4 signalling pathway could be modulated by long-chain polyunsaturated fatty acids (LC-PUFA).	Fatty Acids, Unsaturated	71-98	toll like receptor 4	Homo sapiens	14-18
32064024-5	2020	Moreover, the TLR4 signalling pathway could be modulated by long-chain polyunsaturated fatty acids (LC-PUFA).	Fatty Acids, Unsaturated	71-98	pumilio RNA binding family member 3	Homo sapiens	103-107
31963810-6	2020	Milk from cows grazing chicory contained greater concentrations of polyunsaturated FA (PUFA) such as C18:3 c9, 12, 15 and C18:2 c9, 12 than those on RGWC.	Fatty Acids, Unsaturated	67-85	PUFA	Bos taurus	87-91
31233612-0	2020	Polyunsaturated fatty acids in cod evoke chemotaxis and mobilize intracellular calcium in human eosinophils in part via FFAR4.	Fatty Acids, Unsaturated	0-27	free fatty acid receptor 4	Homo sapiens	120-125
31801692-5	2020	These findings prompted us to re-investigate oxidation of unsaturated fatty acids and fatty alcohols with C9-C16 carbon chain length by CYP4B1.	Fatty Acids, Unsaturated	58-81	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	136-142
32290920-1	2020	OBJECTIVE: To investigate effects of different ratios of n-6/n-3 Polyunsaturated fatty acid(PUFA) on adiponectin, glycolipid metabolism and antioxidant capacity in high fat-diet fed rats.	Fatty Acids, Unsaturated	92-96	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	101-112
31785494-3	2020	Overall, data from clinical studies and meta-analyses suggest an association between high dietary intakes or tissue levels of n-6 PUFA, and specifically LA, and the improvement of cardiovascular risk (mainly of the plasma lipid profile), as well as long-term glycaemic control and insulin resistance.	Fatty Acids, Unsaturated	130-134	insulin	Homo sapiens	281-288
31691133-0	2020	Impact of a Formulation Containing Unusual Polyunsaturated Fatty Acids, Trace Elements, Polyphenols and Plant Sterols on Insulin Resistance and Associated Disturbances.	Fatty Acids, Unsaturated	43-70	insulin	Homo sapiens	121-128
31691133-1	2020	INTRODUCTION: To evaluate the effect of a lipid-based formulation containing unusual polyunsaturated fatty acids, trace elements, polyphenols and plant sterols on insulin resistance and its associated disturbances among adults at risk of diabetes.	Fatty Acids, Unsaturated	85-112	insulin	Homo sapiens	163-170
28583708-13	2020	Reelin expression in this brain region is associated with polyunsaturated fatty acids and ApoE, suggesting further study of potential physiological interactions between these substrates is warranted.	Fatty Acids, Unsaturated	58-85	reelin	Homo sapiens	0-6
33043173-2	2020	ELOVL2 encodes a transmembrane protein involved in the synthesis of very long polyunsaturated fatty acids (VLC-PUFAs).	Fatty Acids, Unsaturated	78-105	ELOVL fatty acid elongase 2	Homo sapiens	0-6
31914617-3	2020	Untargeted imaging mass spectrometry demonstrates cell-specific reduction of phospholipids containing 22:6 and very long-chain polyunsaturated fatty acids (VLC-PUFAs) in Adipor1-/- and Mfrprd6 retinas.	Fatty Acids, Unsaturated	127-154	adiponectin receptor 1	Mus musculus	170-177
31888468-9	2019	Both mechanisms are associated to genes related polyunsaturated fatty acids synthesis (FADS1, ELOVL5 and FADS2), like the arachidonic acid, a precursor of anandamide, a key endocannabinoid, and of prostaglandins, that mediate the regulatory effects of the complement system.	Fatty Acids, Unsaturated	48-75	fatty acid desaturase 1	Gallus gallus	87-92
31888468-9	2019	Both mechanisms are associated to genes related polyunsaturated fatty acids synthesis (FADS1, ELOVL5 and FADS2), like the arachidonic acid, a precursor of anandamide, a key endocannabinoid, and of prostaglandins, that mediate the regulatory effects of the complement system.	Fatty Acids, Unsaturated	48-75	ELOVL fatty acid elongase 5	Gallus gallus	94-100
31888468-9	2019	Both mechanisms are associated to genes related polyunsaturated fatty acids synthesis (FADS1, ELOVL5 and FADS2), like the arachidonic acid, a precursor of anandamide, a key endocannabinoid, and of prostaglandins, that mediate the regulatory effects of the complement system.	Fatty Acids, Unsaturated	48-75	fatty acid desaturase 2	Gallus gallus	105-110
31817645-2	2019	There is increasing evidence that some polyunsaturated fatty acids (PUFAs) exercise specific inhibitory actions on cancer cells through different mechanisms, as a previous study on CRC cells demonstrated for two very long-chain PUFA.	Fatty Acids, Unsaturated	39-66	pumilio RNA binding family member 3	Homo sapiens	68-72
31740932-2	2019	Corn oil (CO) is rich in unsaturated fatty acid with >50% PUFA, which may enhance ruminal biohydrogenation of unsaturated fatty acids, leading to changes in ruminal H2 metabolism and methanogenesis.	Fatty Acids, Unsaturated	25-47	anon-H2	Drosophila melanogaster	165-167
31648559-9	2019	The results of this study indicate that ACSL6 contributes to the local accumulation of DHA- and DPA-containing phospholipids in spermatids to support normal spermatogenesis.-Shishikura, K., Kuroha, S., Matsueda, S., Iseki, H., Matsui, T., Inoue, A., Arita, M. Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice.	Fatty Acids, Unsaturated	303-329	acyl-CoA synthetase long-chain family member 6	Mus musculus	40-45
31810259-1	2019	A retrospective data analysis suggested that the levels of boar taint compounds depend on the polyunsaturated fatty acid (PUFA) level of the adipose tissue (AT) being significantly greater in the unsaturated AT.	Fatty Acids, Unsaturated	122-126	Polyunsaturated fatty acid percentage	Sus scrofa	94-120
31885824-2	2019	The enzyme ALCAT1 catalyzes the conversion of cardiolipin by incorporating polyunsaturated fatty acids into cardiolipin.	Fatty Acids, Unsaturated	75-102	lysocardiolipin acyltransferase 1	Homo sapiens	11-17
31717983-3	2019	Arachidonate 15-lipoxygenase (15-LOX-1) enzyme is involved in polyunsaturated fatty acid metabolism.	Fatty Acids, Unsaturated	62-88	arachidonate 15-lipoxygenase	Homo sapiens	0-28
31455870-8	2019	Further mechanistic study identified that specific unsaturated fatty acid, the oleic acid (C18:1 n-9), incorporated DAGs produced by hepatic lipogenesis are the key molecules to enhance the AR activity, through activation of Akt kinase, and this novel mechanism is targeted by metformin.	Fatty Acids, Unsaturated	51-73	androgen receptor	Mus musculus	190-192
31871543-1	2019	5-Lipoxygenase (ALOX5) is an iron-containing and nonheme dioxygenase that catalyzes the peroxidation of polyunsaturated fatty acids such as arachidonic acid.	Fatty Acids, Unsaturated	104-131	arachidonate 5-lipoxygenase	Homo sapiens	0-14
31871543-1	2019	5-Lipoxygenase (ALOX5) is an iron-containing and nonheme dioxygenase that catalyzes the peroxidation of polyunsaturated fatty acids such as arachidonic acid.	Fatty Acids, Unsaturated	104-131	arachidonate 5-lipoxygenase	Homo sapiens	16-21
31769755-5	2019	We conclude that acs-13 mutations in C. elegans and ACSL1 knockdown in human cells prevent lipotoxicity by promoting increased levels of polyunsaturated fatty acid-containing phospholipids.	Fatty Acids, Unsaturated	137-163	AMP-binding domain-containing protein	Caenorhabditis elegans	17-23
31769755-5	2019	We conclude that acs-13 mutations in C. elegans and ACSL1 knockdown in human cells prevent lipotoxicity by promoting increased levels of polyunsaturated fatty acid-containing phospholipids.	Fatty Acids, Unsaturated	137-163	acyl-CoA synthetase long chain family member 1	Homo sapiens	52-57
31753010-0	2019	Molecular dynamics simulations of the interaction of wild type and mutant human CYP2J2 with polyunsaturated fatty acids.	Fatty Acids, Unsaturated	92-119	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	80-86
31753010-1	2019	OBJECTIVES: The data presented here is part of a study that was aimed at characterizing the molecular mechanisms of polyunsaturated fatty acid metabolism by CYP2J2, the main cytochrome P450 enzyme active in the human cardiovasculature.	Fatty Acids, Unsaturated	116-142	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	157-163
31717983-3	2019	Arachidonate 15-lipoxygenase (15-LOX-1) enzyme is involved in polyunsaturated fatty acid metabolism.	Fatty Acids, Unsaturated	62-88	arachidonate 15-lipoxygenase	Homo sapiens	30-38
31657414-9	2019	To investigate whether PUFAs regulate the expression of enzymes related to hormone synthesis, western blotting was used to determine the protein levels of CYP51, CYP19, StAR and 3beta-HSD.	Fatty Acids, Unsaturated	23-28	cytochrome P450, family 51	Rattus norvegicus	155-160
31349026-2	2019	The current study was designed to determine the profiling activities of various polyunsaturated fatty acid (PUFA) metabolizing enzymes, including lipoxygenases (LO), cyclooxygenase, and cytochrome P450 in the plasma of LPS-injected mice using LC-MS. Heat map analysis revealed that out of 126 bioactive lipids screened, only the 12/15-LO metabolite, 12-HETE, had a significant (2.24 +- 0.4) fold increase relative to control (P = 0.0001) after Bonferroni Correction (BCF alpha = 0.003).	Fatty Acids, Unsaturated	80-106	toll-like receptor 4	Mus musculus	219-222
31349026-2	2019	The current study was designed to determine the profiling activities of various polyunsaturated fatty acid (PUFA) metabolizing enzymes, including lipoxygenases (LO), cyclooxygenase, and cytochrome P450 in the plasma of LPS-injected mice using LC-MS. Heat map analysis revealed that out of 126 bioactive lipids screened, only the 12/15-LO metabolite, 12-HETE, had a significant (2.24 +- 0.4) fold increase relative to control (P = 0.0001) after Bonferroni Correction (BCF alpha = 0.003).	Fatty Acids, Unsaturated	108-112	toll-like receptor 4	Mus musculus	219-222
31376475-0	2019	Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages.	Fatty Acids, Unsaturated	73-95	acyl-CoA synthetase long-chain family member 4	Mus musculus	0-32
31376475-5	2019	Liquid chromatography-tandem mass spectrometry analysis revealed that various highly unsaturated fatty acid (HUFA)-derived fatty acyl-CoA species were markedly decreased in the BMDMs obtained from ACSL4-deficient mice compared with those in the BMDMs obtained from wild-type mice.	Fatty Acids, Unsaturated	85-107	acyl-CoA synthetase long-chain family member 4	Mus musculus	197-202
31511258-0	2019	A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid omega-1 Hydroxylation Using an Untargeted Metabolomic Approach.	Fatty Acids, Unsaturated	51-77	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	28-47
31455615-1	2019	Cyclooxygenase 2 (COX-2) plays a key role in the regulation of inflammation by catalysing the oxygenation of polyunsaturated fatty acids (PUFAs) to prostaglandins and hydroperoxides.	Fatty Acids, Unsaturated	109-136	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
31839812-14	2019	ccRCC samples with higher expression of hub genes were enriched in gene sets correlated with signaling like biosynthesis of unsaturated fatty acids, butanoate metabolism, and PPAR signaling pathway.	Fatty Acids, Unsaturated	124-147	peroxisome proliferator activated receptor alpha	Homo sapiens	175-179
31455615-1	2019	Cyclooxygenase 2 (COX-2) plays a key role in the regulation of inflammation by catalysing the oxygenation of polyunsaturated fatty acids (PUFAs) to prostaglandins and hydroperoxides.	Fatty Acids, Unsaturated	109-136	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
31455615-1	2019	Cyclooxygenase 2 (COX-2) plays a key role in the regulation of inflammation by catalysing the oxygenation of polyunsaturated fatty acids (PUFAs) to prostaglandins and hydroperoxides.	Fatty Acids, Unsaturated	138-143	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
31455615-1	2019	Cyclooxygenase 2 (COX-2) plays a key role in the regulation of inflammation by catalysing the oxygenation of polyunsaturated fatty acids (PUFAs) to prostaglandins and hydroperoxides.	Fatty Acids, Unsaturated	138-143	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
31542928-9	2019	In summary, data suggest that miR-16a regulates biological processes associated with intracellular TAG, cholesterol, and unsaturated fatty acid synthesis through LATS1.	Fatty Acids, Unsaturated	121-143	microRNA 16a	Bos taurus	30-37
31492735-4	2019	However, several more recent studies indicate that small synthetic molecules and unsaturated fatty acids can bind to Nur77.	Fatty Acids, Unsaturated	81-104	nuclear receptor subfamily 4 group A member 1	Homo sapiens	117-122
31506272-2	2019	ZAG belongs to the major histocompatibility complex class I protein family and binds long chain polyunsaturated fatty acids in its groove formed from the alpha1 and alpha2 domains.	Fatty Acids, Unsaturated	96-123	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	0-3
31661783-9	2019	NASH markers of inflammation and fibrosis were inversely associated with hepatic C20-22 omega3 PUFA-derived Cyp2C- and Cyp2J-generated anti-inflammatory oxylipins (false discovery rate adjusted p-value; q &lt;= 0.026).	Fatty Acids, Unsaturated	95-99	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	108-113
31542928-9	2019	In summary, data suggest that miR-16a regulates biological processes associated with intracellular TAG, cholesterol, and unsaturated fatty acid synthesis through LATS1.	Fatty Acids, Unsaturated	121-143	large tumor suppressor kinase 1	Bos taurus	162-167
31616255-2	2019	ELOVL4 is the only family member that catalyzes production of Very Long Chain Saturated Fatty Acids (VLC-SFA) and Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFA) with chain lengths >=28 carbons.	Fatty Acids, Unsaturated	130-157	ELOVL fatty acid elongase 4	Homo sapiens	0-6
31379107-2	2019	Here, we show that both human homologs of Lin28 accelerate de novo fatty acid synthesis and promote the conversion from saturated to unsaturated fatty acids via the regulation of SREBP-1.	Fatty Acids, Unsaturated	133-156	lin-28 homolog A	Homo sapiens	42-47
31379107-2	2019	Here, we show that both human homologs of Lin28 accelerate de novo fatty acid synthesis and promote the conversion from saturated to unsaturated fatty acids via the regulation of SREBP-1.	Fatty Acids, Unsaturated	133-156	sterol regulatory element binding transcription factor 1	Homo sapiens	179-186
31306767-3	2019	Among them, ACSL4 is a unique isozyme that preferentially catalyzes several polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), and ACSL4 is thought to be an important isozyme for PUFA metabolism.	Fatty Acids, Unsaturated	76-103	acyl-CoA synthetase long chain family member 4	Homo sapiens	12-17
31306767-3	2019	Among them, ACSL4 is a unique isozyme that preferentially catalyzes several polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), and ACSL4 is thought to be an important isozyme for PUFA metabolism.	Fatty Acids, Unsaturated	76-103	acyl-CoA synthetase long chain family member 4	Homo sapiens	147-152
31306767-3	2019	Among them, ACSL4 is a unique isozyme that preferentially catalyzes several polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), and ACSL4 is thought to be an important isozyme for PUFA metabolism.	Fatty Acids, Unsaturated	76-103	pumilio RNA binding family member 3	Homo sapiens	105-109
31306767-3	2019	Among them, ACSL4 is a unique isozyme that preferentially catalyzes several polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), and ACSL4 is thought to be an important isozyme for PUFA metabolism.	Fatty Acids, Unsaturated	105-110	acyl-CoA synthetase long chain family member 4	Homo sapiens	12-17
31306767-3	2019	Among them, ACSL4 is a unique isozyme that preferentially catalyzes several polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), and ACSL4 is thought to be an important isozyme for PUFA metabolism.	Fatty Acids, Unsaturated	105-110	acyl-CoA synthetase long chain family member 4	Homo sapiens	147-152
31554167-3	2019	When compared to cow milk, goat milk demonstrated nutritionally desirable traits, such as lower concentrations of C12:0, C14:0, C16:0 and Na: K ratio, and the higher concentrations of cis polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), isoflavones, B, Cu, Mg, Mn, P and I, although the latter may be less desirable in cases of high milk intakes.	Fatty Acids, Unsaturated	184-215	Weaning weight-maternal milk	Bos taurus	32-36
31554167-3	2019	When compared to cow milk, goat milk demonstrated nutritionally desirable traits, such as lower concentrations of C12:0, C14:0, C16:0 and Na: K ratio, and the higher concentrations of cis polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), isoflavones, B, Cu, Mg, Mn, P and I, although the latter may be less desirable in cases of high milk intakes.	Fatty Acids, Unsaturated	184-215	Weaning weight-maternal milk	Bos taurus	32-36
31616255-2	2019	ELOVL4 is the only family member that catalyzes production of Very Long Chain Saturated Fatty Acids (VLC-SFA) and Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFA) with chain lengths >=28 carbons.	Fatty Acids, Unsaturated	130-157	pumilio RNA binding family member 3	Homo sapiens	163-167
30234553-3	2019	In the present study, we quantified the dose-dependent synergistic properties of dietary n-3 polyunsaturated fatty acids (PUFA) and curcumin (Cur) to promote targeted apoptotic deletion of damaged colonic Lgr5 stem cells.	Fatty Acids, Unsaturated	122-126	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	205-209
31500565-2	2019	FAD2 catalyzes the first step, in the biosynthesis of the polyunsaturated fatty acids (PUFAs) found in the cell membrane and cell wall, and it is thus of great importance to investigate the regulatory role of FAD2 in anther development.	Fatty Acids, Unsaturated	58-85	delta(12)-fatty-acid desaturase FAD2	Gossypium hirsutum	0-4
31500565-2	2019	FAD2 catalyzes the first step, in the biosynthesis of the polyunsaturated fatty acids (PUFAs) found in the cell membrane and cell wall, and it is thus of great importance to investigate the regulatory role of FAD2 in anther development.	Fatty Acids, Unsaturated	58-85	delta(12)-fatty-acid desaturase FAD2	Gossypium hirsutum	209-213
31500565-2	2019	FAD2 catalyzes the first step, in the biosynthesis of the polyunsaturated fatty acids (PUFAs) found in the cell membrane and cell wall, and it is thus of great importance to investigate the regulatory role of FAD2 in anther development.	Fatty Acids, Unsaturated	87-92	delta(12)-fatty-acid desaturase FAD2	Gossypium hirsutum	0-4
31500565-2	2019	FAD2 catalyzes the first step, in the biosynthesis of the polyunsaturated fatty acids (PUFAs) found in the cell membrane and cell wall, and it is thus of great importance to investigate the regulatory role of FAD2 in anther development.	Fatty Acids, Unsaturated	87-92	delta(12)-fatty-acid desaturase FAD2	Gossypium hirsutum	209-213
31500565-9	2019	Moreover, the ratio of monounsaturated to polyunsaturated fatty acid was 5.43 in fad2-3 anther, which was much higher than that of the WT (only 0.39).	Fatty Acids, Unsaturated	42-68	delta(12)-fatty-acid desaturase FAD2	Gossypium hirsutum	81-85
31903039-3	2019	The 12/15-lipoxygenase (LOX) is special in that it can directly oxidize lipid membranes containing polyunsaturated fatty acids, without the preceding action of a phospholipase, leading to the direct attack on membranous organelles, such as mitochondria.	Fatty Acids, Unsaturated	99-126	arachidonate 15-lipoxygenase	Homo sapiens	4-22
31903039-3	2019	The 12/15-lipoxygenase (LOX) is special in that it can directly oxidize lipid membranes containing polyunsaturated fatty acids, without the preceding action of a phospholipase, leading to the direct attack on membranous organelles, such as mitochondria.	Fatty Acids, Unsaturated	99-126	arachidonate 15-lipoxygenase	Homo sapiens	24-27
31201181-0	2019	Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling.	Fatty Acids, Unsaturated	49-75	epidermal growth factor receptor	Homo sapiens	97-101
31201181-4	2019	GSCs epigenetically upregulated ELOVL2, a key polyunsaturated fatty-acid synthesis enzyme.	Fatty Acids, Unsaturated	46-72	ELOVL fatty acid elongase 2	Homo sapiens	32-38
31201181-10	2019	GSCs utilize polyunsaturated fatty-acid synthesis to support membrane architecture, inhibition of which impairs EGFR signaling and GSC proliferation.	Fatty Acids, Unsaturated	13-39	epidermal growth factor receptor	Homo sapiens	112-116
31481405-1	2019	In this issue of Cancer Discovery, Gimple and colleagues examine superenhancers in glioblastoma and glioma stem cells (GSC), identifying one which promotes expression of ELOVL2, an enzyme in polyunsaturated fatty acid (PUFA) synthesis.	Fatty Acids, Unsaturated	191-217	ELOVL fatty acid elongase 2	Homo sapiens	170-176
31481405-1	2019	In this issue of Cancer Discovery, Gimple and colleagues examine superenhancers in glioblastoma and glioma stem cells (GSC), identifying one which promotes expression of ELOVL2, an enzyme in polyunsaturated fatty acid (PUFA) synthesis.	Fatty Acids, Unsaturated	219-223	ELOVL fatty acid elongase 2	Homo sapiens	170-176
31418690-7	2019	Instead, CCTalpha-null macrophages had lower membrane PC turnover, leading to elevated membrane polyunsaturated fatty acid levels that negated the pro-inflammatory effects of palmitate.	Fatty Acids, Unsaturated	96-122	phosphate cytidylyltransferase 1A, choline	Homo sapiens	9-17
31455761-0	2019	Altered polyunsaturated fatty acid levels in relation to proinflammatory cytokines, fatty acid desaturase genotype, and diet in bipolar disorder.	Fatty Acids, Unsaturated	8-34	stearoyl-CoA desaturase	Homo sapiens	84-105
31073775-9	2019	However, consistently downregulated genes during early postpartum showed immunosuppression, the downregulation of gluconeogenesis from amino acids (e.g., DDO), and the biosynthesis of taurine (e.g., CSAD) and unsaturated fatty acids (e.g., SCD).	Fatty Acids, Unsaturated	209-232	D-aspartate oxidase	Homo sapiens	154-157
31073775-9	2019	However, consistently downregulated genes during early postpartum showed immunosuppression, the downregulation of gluconeogenesis from amino acids (e.g., DDO), and the biosynthesis of taurine (e.g., CSAD) and unsaturated fatty acids (e.g., SCD).	Fatty Acids, Unsaturated	209-232	cysteine sulfinic acid decarboxylase	Homo sapiens	199-203
31069808-7	2019	The phyB mutant showed reduced expression of several fatty acid desaturase (FAD) genes and less proportion of fully unsaturated fatty acids and electrolyte leakage of membranes exposed to heat shocks.	Fatty Acids, Unsaturated	116-139	phytochrome B	Arabidopsis thaliana	4-8
31413283-1	2019	The role of marine lipids as modulators of ruminal biohydrogenation of dietary unsaturated fatty acids may be explained by the effects of their n-3 polyunsaturated fatty acids (PUFA) on the bacterial community.	Fatty Acids, Unsaturated	79-102	PUFA	Bos taurus	148-175
31434800-0	2019	Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	58-85	patatin like phospholipase domain containing 3	Homo sapiens	6-12
31413283-1	2019	The role of marine lipids as modulators of ruminal biohydrogenation of dietary unsaturated fatty acids may be explained by the effects of their n-3 polyunsaturated fatty acids (PUFA) on the bacterial community.	Fatty Acids, Unsaturated	79-102	PUFA	Bos taurus	177-181
31382500-5	2019	Thus, LXRs activate the production of polyunsaturated fatty acids (PUFAs) and their distribution into phospholipids via the control of FA desaturases, FA elongases, lysophosphatidylcholine acyltransferase (LPCAT3), and phospholipid transfer protein (PLTP).	Fatty Acids, Unsaturated	38-65	lysophosphatidylcholine acyltransferase 3	Homo sapiens	206-212
31408455-5	2019	We show that MDT-15 up-regulates fat-7, a fatty acid desaturase that converts saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), at low temperatures.	Fatty Acids, Unsaturated	110-133	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	13-19
31408455-5	2019	We show that MDT-15 up-regulates fat-7, a fatty acid desaturase that converts saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), at low temperatures.	Fatty Acids, Unsaturated	135-139	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	13-19
31406145-5	2019	In contrast, drastic changes were observed in spinal cord of SOD1-G93A 120d group, including decreased levels of cardiolipin and a 6-fold increase in several cholesteryl esters linked to polyunsaturated fatty acids.	Fatty Acids, Unsaturated	187-214	superoxide dismutase 1	Rattus norvegicus	61-65
31382500-5	2019	Thus, LXRs activate the production of polyunsaturated fatty acids (PUFAs) and their distribution into phospholipids via the control of FA desaturases, FA elongases, lysophosphatidylcholine acyltransferase (LPCAT3), and phospholipid transfer protein (PLTP).	Fatty Acids, Unsaturated	38-65	phospholipid transfer protein	Homo sapiens	219-248
31382500-5	2019	Thus, LXRs activate the production of polyunsaturated fatty acids (PUFAs) and their distribution into phospholipids via the control of FA desaturases, FA elongases, lysophosphatidylcholine acyltransferase (LPCAT3), and phospholipid transfer protein (PLTP).	Fatty Acids, Unsaturated	38-65	phospholipid transfer protein	Homo sapiens	250-254
31382500-5	2019	Thus, LXRs activate the production of polyunsaturated fatty acids (PUFAs) and their distribution into phospholipids via the control of FA desaturases, FA elongases, lysophosphatidylcholine acyltransferase (LPCAT3), and phospholipid transfer protein (PLTP).	Fatty Acids, Unsaturated	67-72	lysophosphatidylcholine acyltransferase 3	Homo sapiens	206-212
31382500-5	2019	Thus, LXRs activate the production of polyunsaturated fatty acids (PUFAs) and their distribution into phospholipids via the control of FA desaturases, FA elongases, lysophosphatidylcholine acyltransferase (LPCAT3), and phospholipid transfer protein (PLTP).	Fatty Acids, Unsaturated	67-72	phospholipid transfer protein	Homo sapiens	219-248
31382500-5	2019	Thus, LXRs activate the production of polyunsaturated fatty acids (PUFAs) and their distribution into phospholipids via the control of FA desaturases, FA elongases, lysophosphatidylcholine acyltransferase (LPCAT3), and phospholipid transfer protein (PLTP).	Fatty Acids, Unsaturated	67-72	phospholipid transfer protein	Homo sapiens	250-254
31677539-6	2019	Studies showed that IL-6 and TNF-alpha activate phospholipases to induce the release of polyunsaturated fatty acids (PUFAs) from the cell membrane phospholipid pool.	Fatty Acids, Unsaturated	88-115	interleukin 6	Homo sapiens	20-24
31677539-6	2019	Studies showed that IL-6 and TNF-alpha activate phospholipases to induce the release of polyunsaturated fatty acids (PUFAs) from the cell membrane phospholipid pool.	Fatty Acids, Unsaturated	88-115	tumor necrosis factor	Homo sapiens	29-38
31677539-6	2019	Studies showed that IL-6 and TNF-alpha activate phospholipases to induce the release of polyunsaturated fatty acids (PUFAs) from the cell membrane phospholipid pool.	Fatty Acids, Unsaturated	117-122	interleukin 6	Homo sapiens	20-24
31677539-6	2019	Studies showed that IL-6 and TNF-alpha activate phospholipases to induce the release of polyunsaturated fatty acids (PUFAs) from the cell membrane phospholipid pool.	Fatty Acids, Unsaturated	117-122	tumor necrosis factor	Homo sapiens	29-38
31677539-7	2019	PUFAs form precursors to pro- and anti-inflammatory eicosanoids and are capable of suppressing IL-6 and TNF-alpha excess production.	Fatty Acids, Unsaturated	0-5	interleukin 6	Homo sapiens	95-99
31677539-7	2019	PUFAs form precursors to pro- and anti-inflammatory eicosanoids and are capable of suppressing IL-6 and TNF-alpha excess production.	Fatty Acids, Unsaturated	0-5	tumor necrosis factor	Homo sapiens	104-113
30082751-1	2019	BACKGROUND: Single nucleotide polymorphisms (SNPs) in FADS1/FADS2 genes are associated with changes in serum and tissue polyunsaturated fatty acid (PUFA) content.	Fatty Acids, Unsaturated	120-146	fatty acid desaturase 1	Homo sapiens	54-59
31129422-2	2019	Pharmacological stimulation of G-protein coupled receptor (GPR) 40, a receptor of polyunsaturated fatty acids, have recently been shown to promote tight junction assembly in airway epithelial cells under non-inflammatory conditions.	Fatty Acids, Unsaturated	82-109	free fatty acid receptor 1	Homo sapiens	31-66
31144304-13	2019	Importantly, DHFR expression was suppressed by palmitic acid (PA, a saturated fatty acid) but increased by docosahexaenoic acid (DHA, a polyunsaturated fatty acid).	Fatty Acids, Unsaturated	136-162	dihydrofolate reductase	Mus musculus	13-17
30082751-1	2019	BACKGROUND: Single nucleotide polymorphisms (SNPs) in FADS1/FADS2 genes are associated with changes in serum and tissue polyunsaturated fatty acid (PUFA) content.	Fatty Acids, Unsaturated	120-146	fatty acid desaturase 2	Homo sapiens	60-65
30082751-1	2019	BACKGROUND: Single nucleotide polymorphisms (SNPs) in FADS1/FADS2 genes are associated with changes in serum and tissue polyunsaturated fatty acid (PUFA) content.	Fatty Acids, Unsaturated	148-152	fatty acid desaturase 1	Homo sapiens	54-59
30082751-1	2019	BACKGROUND: Single nucleotide polymorphisms (SNPs) in FADS1/FADS2 genes are associated with changes in serum and tissue polyunsaturated fatty acid (PUFA) content.	Fatty Acids, Unsaturated	148-152	fatty acid desaturase 2	Homo sapiens	60-65
31221730-11	2019	The synthetic lethal phenotype of dgat1 with plip1 indicates an important role for PLIP1 in the absence of DGAT1 activity, likely by supplying polyunsaturated fatty acid substrates for PDAT1.	Fatty Acids, Unsaturated	143-169	membrane bound O-acyl transferase (MBOAT) family protein	Arabidopsis thaliana	34-39
31167809-3	2019	EFAs and long-chain (LC)-PUFAs are precursors in the synthesis of endocannabinoid ligands of Gi/o protein-coupled cannabinoid receptor (CB)1 and CB2 in the endocannabinoid system, which critically regulate energy homeostasis as the metabolic signaling system in hypothalamic neuronal circuits and behavioral parameters.	Fatty Acids, Unsaturated	25-30	cannabinoid receptor 1	Homo sapiens	93-140
31167809-3	2019	EFAs and long-chain (LC)-PUFAs are precursors in the synthesis of endocannabinoid ligands of Gi/o protein-coupled cannabinoid receptor (CB)1 and CB2 in the endocannabinoid system, which critically regulate energy homeostasis as the metabolic signaling system in hypothalamic neuronal circuits and behavioral parameters.	Fatty Acids, Unsaturated	25-30	cannabinoid receptor 2	Homo sapiens	145-148
31221730-11	2019	The synthetic lethal phenotype of dgat1 with plip1 indicates an important role for PLIP1 in the absence of DGAT1 activity, likely by supplying polyunsaturated fatty acid substrates for PDAT1.	Fatty Acids, Unsaturated	143-169	phospholipid:diacylglycerol acyltransferase	Arabidopsis thaliana	185-190
31467878-7	2019	Further, bta-mir-124a regulates the expression of PECR and the downstream gene extension of very long chain fatty acid protein 2 (ELOVL2) through an unsaturated fatty acid biosynthesis signaling pathway.	Fatty Acids, Unsaturated	149-171	microRNA 124A	Bos taurus	9-21
31037571-0	2019	Co-expression of fat1 and fat2 in transgenic pigs promotes synthesis of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	72-99	protocadherin Fat 1	Sus scrofa	17-21
31037571-0	2019	Co-expression of fat1 and fat2 in transgenic pigs promotes synthesis of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	72-99	FAT atypical cadherin 2	Sus scrofa	26-30
31467878-7	2019	Further, bta-mir-124a regulates the expression of PECR and the downstream gene extension of very long chain fatty acid protein 2 (ELOVL2) through an unsaturated fatty acid biosynthesis signaling pathway.	Fatty Acids, Unsaturated	149-171	peroxisomal trans-2-enoyl-CoA reductase	Bos taurus	50-54
31467878-7	2019	Further, bta-mir-124a regulates the expression of PECR and the downstream gene extension of very long chain fatty acid protein 2 (ELOVL2) through an unsaturated fatty acid biosynthesis signaling pathway.	Fatty Acids, Unsaturated	149-171	ELOVL fatty acid elongase 2	Bos taurus	130-136
31333461-4	2019	Cytochrome P450 enzymes metabolize endogenous substrates (polyunsaturated fatty acids) to bioactive fatty acid epoxides that demonstrate biological activity with generally protective/anti-inflammatory and insulin-sensitizing effects.	Fatty Acids, Unsaturated	58-85	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
31349671-4	2019	The result showed that with placebo as the reference, PUFAs was the only treatment showing significantly lower CRP (weighted mean difference (WMD): -0.37, 95% confidence interval (CI): -0.07 to -0.68), but the CRP in PUFAs group was not significantly lower than vitamin E, PUFAs plus vitamin E, or medium-chain triglyceride.	Fatty Acids, Unsaturated	54-59	C-reactive protein	Homo sapiens	111-114
31349671-4	2019	The result showed that with placebo as the reference, PUFAs was the only treatment showing significantly lower CRP (weighted mean difference (WMD): -0.37, 95% confidence interval (CI): -0.07 to -0.68), but the CRP in PUFAs group was not significantly lower than vitamin E, PUFAs plus vitamin E, or medium-chain triglyceride.	Fatty Acids, Unsaturated	54-59	C-reactive protein	Homo sapiens	210-213
31108791-4	2019	In this way, chia seeds (Salvia hispanica L.), rich in polyunsaturated fatty acids, may present an anti-inflammatory role.	Fatty Acids, Unsaturated	55-82	chitinase, acidic 1	Mus musculus	13-17
30488812-2	2019	We hypothesize that nature of energy (starch v. lipids) and lipid supplement types (monounsaturated fatty acid (MUFA) v. polyunsaturated fatty acid (PUFA) mitigate CH4 emissions and can induce low milk fat content via different pathways.	Fatty Acids, Unsaturated	121-147	PUFA	Bos taurus	149-153
30918020-8	2019	We also identified increases in polyunsaturated fatty acids (PUFA) and thioredoxin-interacting protein (TXNIP) as potential pharmacodynamics biomarkers for targeting BET proteins.	Fatty Acids, Unsaturated	32-59	delta/notch like EGF repeat containing	Homo sapiens	166-169
30918020-8	2019	We also identified increases in polyunsaturated fatty acids (PUFA) and thioredoxin-interacting protein (TXNIP) as potential pharmacodynamics biomarkers for targeting BET proteins.	Fatty Acids, Unsaturated	61-65	delta/notch like EGF repeat containing	Homo sapiens	166-169
30981081-4	2019	produced endogenously by the non-enzymatic reaction of NO with unsaturated fatty acids, are found to be potent activators of the transcription factor, peroxisome proliferator-activated receptor gamma (PPARgamma).	Fatty Acids, Unsaturated	63-86	peroxisome proliferator activated receptor gamma	Mus musculus	151-199
31320765-1	2019	Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the most important long-chain polyunsaturated fatty acids of the n-3 series (n-3 PUFA).	Fatty Acids, Unsaturated	93-120	pumilio RNA binding family member 3	Homo sapiens	144-148
30981081-4	2019	produced endogenously by the non-enzymatic reaction of NO with unsaturated fatty acids, are found to be potent activators of the transcription factor, peroxisome proliferator-activated receptor gamma (PPARgamma).	Fatty Acids, Unsaturated	63-86	peroxisome proliferator activated receptor gamma	Mus musculus	201-210
31085629-6	2019	These results suggest that PUFA-containing phospholipids and C14 fatty-acid-containing DAGs in lipophorin could be transferred to different sites by different mechanisms to selectively transport fatty acids using a single class of lipoproteins.	Fatty Acids, Unsaturated	27-31	apolipophorin	Drosophila melanogaster	95-105
31073727-1	2019	PURPOSE: To determine if levels of very long chain polyunsaturated fatty acids (VLC-PUFA; &gt;= 28 carbons;4-6 double bonds) in human sperm correlate with sperm quantity and quality as determined by a complete semen analysis.	Fatty Acids, Unsaturated	51-78	pumilio RNA binding family member 3	Homo sapiens	84-88
31139819-9	2019	The portion of palmitoleic acid and oleic acid were increased in SCD-overexpressing parasites, compared with the RH parental strain, indicating that T. gondii indeed is competent for unsaturated fatty acid synthesis.	Fatty Acids, Unsaturated	183-205	stearoyl-CoA desaturase	Homo sapiens	65-68
31528014-9	2019	Results: We found that enhanced lipid peroxidation of unsaturated fatty acids of membrane structures stimulates the generalization of inflammatory process, as evidenced by the significant deviation from the physiologically normal values of lipid peroxidation, C-reactive protein, blood cell count, etc.	Fatty Acids, Unsaturated	54-77	C-reactive protein	Canis lupus familiaris	260-278
31242694-12	2019	Collectively, our data highlighted a role of ELOVL7 in long-chain unsaturated fatty acid elongation in goat mammary epithelial cells.	Fatty Acids, Unsaturated	66-88	elongation of very long chain fatty acids protein 7	Capra hircus	45-51
30977236-1	2019	Polyunsaturated fatty acid consumption has been shown to improve insulin sensitivity.	Fatty Acids, Unsaturated	0-26	insulin	Bos taurus	65-72
31086922-4	2019	Concerning their nutritional aspects, chia seeds are an excellent source of fat (20% to 34%), particularly polyunsaturated fatty acids such as alpha-linolenic (60%) and linoleic (20%) acids.	Fatty Acids, Unsaturated	107-134	chitinase acidic	Homo sapiens	38-42
31117349-3	2019	We have investigated the reactivity of mitoNEET toward the reactive electrophiles 4-hydroxynonenal (HNE) and 4-oxononenal (ONE) that are produced from the oxidation of polyunsaturated fatty acid during oxidative stress.	Fatty Acids, Unsaturated	168-194	CDGSH iron sulfur domain 1	Homo sapiens	39-47
31209255-2	2019	TGRL from subjects consuming a high saturated fat test meal elicited a variable inflammatory response in TNFalpha-stimulated endothelial cells (EC) that correlated strongly with the polyunsaturated fatty acid (PUFA) content.	Fatty Acids, Unsaturated	182-208	tumor necrosis factor	Homo sapiens	105-113
31209255-2	2019	TGRL from subjects consuming a high saturated fat test meal elicited a variable inflammatory response in TNFalpha-stimulated endothelial cells (EC) that correlated strongly with the polyunsaturated fatty acid (PUFA) content.	Fatty Acids, Unsaturated	210-214	tumor necrosis factor	Homo sapiens	105-113
31239715-10	2019	Function analysis demonstrated that FLJ33360 can act as a molecular sponge of miR-30b-3p to regulate the expression of target genes that are mainly involved in positive regulation of smooth muscle cell migration, the unsaturated fatty acid metabolic process, and positive regulation of the epithelial to mesenchymal transition.	Fatty Acids, Unsaturated	217-239	long intergenic non-protein coding RNA 2145	Homo sapiens	36-44
31239715-10	2019	Function analysis demonstrated that FLJ33360 can act as a molecular sponge of miR-30b-3p to regulate the expression of target genes that are mainly involved in positive regulation of smooth muscle cell migration, the unsaturated fatty acid metabolic process, and positive regulation of the epithelial to mesenchymal transition.	Fatty Acids, Unsaturated	217-239	microRNA 30b	Homo sapiens	78-85
31281828-9	2019	And LPGAT1, PDK4, ACAA1, and ADIPOQ were associated with the content of stearic acid, octadecadienoic acid, and polyunsaturated fatty acid.	Fatty Acids, Unsaturated	112-138	LPGAT1	Sus scrofa	4-10
31281828-9	2019	And LPGAT1, PDK4, ACAA1, and ADIPOQ were associated with the content of stearic acid, octadecadienoic acid, and polyunsaturated fatty acid.	Fatty Acids, Unsaturated	112-138	pyruvate dehydrogenase kinase 4	Sus scrofa	12-16
31281828-9	2019	And LPGAT1, PDK4, ACAA1, and ADIPOQ were associated with the content of stearic acid, octadecadienoic acid, and polyunsaturated fatty acid.	Fatty Acids, Unsaturated	112-138	acetyl-CoA acyltransferase 1	Sus scrofa	18-23
31281828-9	2019	And LPGAT1, PDK4, ACAA1, and ADIPOQ were associated with the content of stearic acid, octadecadienoic acid, and polyunsaturated fatty acid.	Fatty Acids, Unsaturated	112-138	adiponectin, C1Q and collagen domain containing	Sus scrofa	29-35
30977236-2	2019	We studied if administration of broth with beef meat enriched with polyunsaturated fatty acids influenced glucose-stimulated insulin release in healthy male volunteers.	Fatty Acids, Unsaturated	67-94	insulin	Bos taurus	125-132
30010011-0	2019	Selectivity of phospholipid hydrolysis by phospholipase A2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization.	Fatty Acids, Unsaturated	97-123	phospholipase A2 group IB	Homo sapiens	42-58
31068339-4	2019	MDGI silencing impaired trafficking of polyunsaturated fatty acids into cells resulting in significant alterations in the lipid composition of lysosomal membranes, and subsequent death of the patient-derived glioma cells via lysosomal membrane permeabilization (LMP).	Fatty Acids, Unsaturated	39-66	fatty acid binding protein 3	Homo sapiens	0-4
30945068-11	2019	The novel targets revealed that the metabolism of the vitamin B group, the synthesis of unsaturated fatty acids and glycosphingolipids are involved in the Ang II-related cognitive impairment.	Fatty Acids, Unsaturated	88-111	angiotensinogen	Homo sapiens	155-161
29675558-0	2019	Dietary polyunsaturated fatty acids mediate the inverse association of stearoyl-CoA desaturase activity with the risk of fatty liver in dyslipidaemic individuals.	Fatty Acids, Unsaturated	8-35	stearoyl-CoA desaturase	Homo sapiens	71-94
29675558-2	2019	Polyunsaturated fatty acids (PUFA) inhibit SCD1, but clinical studies on whether all dietary PUFA species are equal in SCD1 inhibition are scarce.	Fatty Acids, Unsaturated	0-27	stearoyl-CoA desaturase	Homo sapiens	43-47
29675558-2	2019	Polyunsaturated fatty acids (PUFA) inhibit SCD1, but clinical studies on whether all dietary PUFA species are equal in SCD1 inhibition are scarce.	Fatty Acids, Unsaturated	29-33	stearoyl-CoA desaturase	Homo sapiens	43-47
31253430-4	2019	Meanwhile, compared to the controls, H007 significantly inhibited sterol-regulatory element binding protein (SREBP)-1c and acetyl CoA carboxylase (ACC) expression by upregulating the AMPK activity, suppressing the saturated fatty acid accumulation and increasing polyunsaturated fatty acid synthesis in the liver.	Fatty Acids, Unsaturated	263-289	sterol regulatory element binding transcription factor 1	Homo sapiens	109-118
30981483-2	2019	Feeding high amounts of starch and unsaturated fatty acids has been shown to reduce milk fat yield and composition, as well as alter ruminal biohydrogenation patterns.	Fatty Acids, Unsaturated	35-58	Weaning weight-maternal milk	Bos taurus	84-88
31091801-2	2019	The TWIK-related potassium channel-1 (TREK-1) is inhibited by BPV and activated by polyunsaturated fatty acids, which are the main component in LE.	Fatty Acids, Unsaturated	83-110	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	38-44
31101849-0	2019	CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes.	Fatty Acids, Unsaturated	99-126	elongation of very long chain fatty acids protein 2	Salmo salar	33-39
30954631-0	2019	Serelaxin (recombinant human relaxin-2) treatment affects the endogenous synthesis of long chain poly-unsaturated fatty acids and induces substantial alterations of lipidome and metabolome profiles in rat cardiac tissue.	Fatty Acids, Unsaturated	97-125	relaxin 2	Homo sapiens	29-38
31214021-3	2019	Epoxides of polyunsaturated fatty acids (PUFAs) are anti-inflammatory lipid mediators that are rapidly metabolized by the soluble epoxide hydrolase (sEH) into corresponding vicinal diols.	Fatty Acids, Unsaturated	12-39	epoxide hydrolase 2	Homo sapiens	149-152
31214021-3	2019	Epoxides of polyunsaturated fatty acids (PUFAs) are anti-inflammatory lipid mediators that are rapidly metabolized by the soluble epoxide hydrolase (sEH) into corresponding vicinal diols.	Fatty Acids, Unsaturated	41-46	epoxide hydrolase 2	Homo sapiens	149-152
30914501-0	2019	DHA intake interacts with ELOVL2 and ELOVL5 genetic variants to influence polyunsaturated fatty acids in human milk.	Fatty Acids, Unsaturated	74-101	ELOVL fatty acid elongase 5	Homo sapiens	37-43
31074378-9	2019	In the study of the effects of polyunsaturated fatty acids (PUFA), namely, docosahexaenoic (DHA) and eicosapentaenoic (EPA) diets on mouse small intestine cells, the inferences of regulations are consistent with those reported in the literature, including PPARalpha and NFkappaB, respectively corresponding to enhanced adipogenesis and reduced inflammation.	Fatty Acids, Unsaturated	31-58	peroxisome proliferator activated receptor alpha	Mus musculus	256-265
31074378-9	2019	In the study of the effects of polyunsaturated fatty acids (PUFA), namely, docosahexaenoic (DHA) and eicosapentaenoic (EPA) diets on mouse small intestine cells, the inferences of regulations are consistent with those reported in the literature, including PPARalpha and NFkappaB, respectively corresponding to enhanced adipogenesis and reduced inflammation.	Fatty Acids, Unsaturated	31-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	270-278
31231138-1	2019	Human 15-lipoxygenase-1 (15-LOX-1) belongs to the class of lipoxygenases, which catalyze oxygenation of polyunsaturated fatty acids, such as arachidonic and linoleic acid.	Fatty Acids, Unsaturated	104-131	arachidonate 15-lipoxygenase	Homo sapiens	6-23
31231138-1	2019	Human 15-lipoxygenase-1 (15-LOX-1) belongs to the class of lipoxygenases, which catalyze oxygenation of polyunsaturated fatty acids, such as arachidonic and linoleic acid.	Fatty Acids, Unsaturated	104-131	arachidonate 15-lipoxygenase	Homo sapiens	25-33
30914501-0	2019	DHA intake interacts with ELOVL2 and ELOVL5 genetic variants to influence polyunsaturated fatty acids in human milk.	Fatty Acids, Unsaturated	74-101	ELOVL fatty acid elongase 2	Homo sapiens	26-32
30825045-1	2019	OBJECTIVE: To quantitatively hydroxylate 8S- and 10S-positions on polyunsaturated fatty acids by recombinant Escherichia coli cells expressing mouse arachidonate 8S-lipoxygenase (8S-LOX).	Fatty Acids, Unsaturated	66-93	arachidonate 8-lipoxygenase	Mus musculus	149-177
30825045-1	2019	OBJECTIVE: To quantitatively hydroxylate 8S- and 10S-positions on polyunsaturated fatty acids by recombinant Escherichia coli cells expressing mouse arachidonate 8S-lipoxygenase (8S-LOX).	Fatty Acids, Unsaturated	66-93	arachidonate 8-lipoxygenase	Mus musculus	179-185
30914501-1	2019	Endogenous synthesis of PUFAs is mediated by genes controlling fatty acid elongases 2 and 5 (ELOVL2 and ELOVL5) and by exogenous DHA intake.	Fatty Acids, Unsaturated	24-29	ELOVL fatty acid elongase 2	Homo sapiens	93-99
30914501-1	2019	Endogenous synthesis of PUFAs is mediated by genes controlling fatty acid elongases 2 and 5 (ELOVL2 and ELOVL5) and by exogenous DHA intake.	Fatty Acids, Unsaturated	24-29	ELOVL fatty acid elongase 5	Homo sapiens	104-110
29758301-5	2019	Specifically, lipids and lipid derivatives such as polyunsaturated fatty acids (PUFAs), ceramides and steroids have been shown to directly interact with the lipid facing amino acids in various Kv channels including hERG.	Fatty Acids, Unsaturated	51-78	ETS transcription factor ERG	Homo sapiens	215-219
30620245-6	2019	Plasma polyunsaturated fatty acid (PUFA) levels were negatively associated with weight (p = 0.046), systolic blood pressure (p = 0.035), fasting glucose (p = 0.000), triglyceride-glucose index (p = 0.023), and IL-1beta (p = 0.037).	Fatty Acids, Unsaturated	7-33	interleukin 1 alpha	Homo sapiens	210-218
30620245-6	2019	Plasma polyunsaturated fatty acid (PUFA) levels were negatively associated with weight (p = 0.046), systolic blood pressure (p = 0.035), fasting glucose (p = 0.000), triglyceride-glucose index (p = 0.023), and IL-1beta (p = 0.037).	Fatty Acids, Unsaturated	35-39	interleukin 1 alpha	Homo sapiens	210-218
29758301-5	2019	Specifically, lipids and lipid derivatives such as polyunsaturated fatty acids (PUFAs), ceramides and steroids have been shown to directly interact with the lipid facing amino acids in various Kv channels including hERG.	Fatty Acids, Unsaturated	80-85	ETS transcription factor ERG	Homo sapiens	215-219
30979019-3	2019	Unsaturated fatty acids (UFA) are known to inhibit osteoclastogenesis by targeting RANKL signalling.	Fatty Acids, Unsaturated	0-23	TNF superfamily member 11	Homo sapiens	83-88
30708259-11	2019	The fast food-type pattern was further associated with higher levels of C-reactive protein and uric acid and the unsaturated fatty acid pattern with reduced levels of insulin and homeostatic model assessment of insulin resistance (P &lt; 0.05).	Fatty Acids, Unsaturated	113-135	insulin	Homo sapiens	167-174
30660714-7	2019	The milk polyunsaturated fatty acid content was increased in Azgp1-/- mice.	Fatty Acids, Unsaturated	9-35	alpha-2-glycoprotein 1, zinc	Mus musculus	61-66
30962574-6	2019	Moreover, ALOX12 missense mutations from human cancers abrogate its ability to oxygenate polyunsaturated fatty acids and to induce p53-mediated ferroptosis.	Fatty Acids, Unsaturated	89-116	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	10-16
30979019-3	2019	Unsaturated fatty acids (UFA) are known to inhibit osteoclastogenesis by targeting RANKL signalling.	Fatty Acids, Unsaturated	25-28	TNF superfamily member 11	Homo sapiens	83-88
30979019-9	2019	Polyunsaturated fatty acids increased PPAR-alpha to a greater extent than monounsaturated fatty acids (MUFAs), which favoured PPAR-beta/delta activation.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Homo sapiens	38-48
30979019-9	2019	Polyunsaturated fatty acids increased PPAR-alpha to a greater extent than monounsaturated fatty acids (MUFAs), which favoured PPAR-beta/delta activation.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor delta	Homo sapiens	126-135
30943390-1	2019	delta-5 desaturase and delta-6 desaturase are enzymes known to be involved in the synthesis of highly unsaturated fatty acids.	Fatty Acids, Unsaturated	102-125	fatty acid desaturase 1	Homo sapiens	0-18
30943390-1	2019	delta-5 desaturase and delta-6 desaturase are enzymes known to be involved in the synthesis of highly unsaturated fatty acids.	Fatty Acids, Unsaturated	102-125	fatty acid desaturase 2	Homo sapiens	23-41
30871233-14	2019	Our findings demonstrate that, in the context of a low-fat vegan diet, decreased intake of saturated and trans fats and increased relative content of polyunsaturated fatty acids, particularly linoleic and alpha-linolenic acids, are associated with decreased fat mass and insulin resistance, and enhanced insulin secretion.	Fatty Acids, Unsaturated	150-177	insulin	Homo sapiens	271-278
29520627-1	2019	PURPOSE: Our aim was to evaluate the postprandial effect of an oral fat load test (OFLT) rich in unsaturated fatty acids on gene expression profile in peripheral blood mononuclear cells (PBMC) from subjects with abdominal obesity as an insulin resistance model and controls.	Fatty Acids, Unsaturated	97-120	insulin	Homo sapiens	236-243
29520627-8	2019	CONCLUSIONS: Our results suggest that an OFLT rich in unsaturated fatty acids downregulates the expression of FKBP5, coding for the glucocorticoid receptor pathway, and that of DDIT4, involved in the oxidative stress response.	Fatty Acids, Unsaturated	54-77	FKBP prolyl isomerase 5	Homo sapiens	110-115
29520627-8	2019	CONCLUSIONS: Our results suggest that an OFLT rich in unsaturated fatty acids downregulates the expression of FKBP5, coding for the glucocorticoid receptor pathway, and that of DDIT4, involved in the oxidative stress response.	Fatty Acids, Unsaturated	54-77	DNA damage inducible transcript 4	Homo sapiens	177-182
29795460-2	2019	Our objectives were to systematically assess whether dietary polyunsaturated fatty acid (PUFA) intake modifies the associations between genetic variants in the FADS gene cluster and cardiometabolic traits, and to functionally annotate top-ranking candidates to estimate their regulatory potential.	Fatty Acids, Unsaturated	61-87	muscle associated receptor tyrosine kinase	Homo sapiens	160-164
29795460-2	2019	Our objectives were to systematically assess whether dietary polyunsaturated fatty acid (PUFA) intake modifies the associations between genetic variants in the FADS gene cluster and cardiometabolic traits, and to functionally annotate top-ranking candidates to estimate their regulatory potential.	Fatty Acids, Unsaturated	89-93	muscle associated receptor tyrosine kinase	Homo sapiens	160-164
30771734-0	2019	Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach.	Fatty Acids, Unsaturated	0-23	free fatty acid receptor 4	Mus musculus	64-70
31007954-8	2019	Moreover, the carriers of GG genotype with high polyunsaturated fatty acid intake (&gt;=6% of TE/day) had significantly lower HOMA-IR (1.5 +- 0.3 vs 3.0 +- 0.7, p=0.026) and fasting insulin levels (6.8 +- 1.6 microU/mL vs 11.4 +- 2.1 microU/mL, p=0.036).	Fatty Acids, Unsaturated	48-74	insulin	Homo sapiens	182-189
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Fatty Acids, Unsaturated	3-8	latexin	Homo sapiens	18-21
30851732-22	2019	CONCLUSION: Low melting point fractions of buffalo milk fat had higher concentration of unsaturated fatty acids and more antioxidant capacity than unmodified milk fat with reasonable storage stability.	Fatty Acids, Unsaturated	88-111	Weaning weight-maternal milk	Bos taurus	51-55
30685090-0	2019	The binding of monomeric amyloid beta peptide to serum albumin is affected by major plasma unsaturated fatty acids.	Fatty Acids, Unsaturated	91-114	albumin	Homo sapiens	55-62
30685090-6	2019	The parameters of the HSA-Abeta interaction are selectively sensitive to HSA binding of major plasma unsaturated fatty acids and Cu2+.	Fatty Acids, Unsaturated	101-124	amyloid beta precursor protein	Homo sapiens	26-31
30832586-6	2019	By performing a GWAS for IMF content and composition traits recorded in the LD and GM muscles of 350 Duroc pigs, we identified the existence of one region on SSC14 (110-114 Mb) displaying significant associations with C18:0, C18:1(n-7), saturated and unsaturated fatty acid contents in both GM and LD muscles.	Fatty Acids, Unsaturated	251-273	IMF	Sus scrofa	25-28
30677594-2	2019	There is some evidence that supplemental omega-3 dietary polyunsaturated fatty acids (n-3 PUFA) can exert positive effects on fertility.	Fatty Acids, Unsaturated	57-84	PUFA	Bos taurus	90-94
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Fatty Acids, Unsaturated	3-8	latexin	Homo sapiens	31-34
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Fatty Acids, Unsaturated	3-8	latexin	Homo sapiens	31-34
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Fatty Acids, Unsaturated	3-8	inositol-3-phosphate synthase 1	Homo sapiens	108-112
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Fatty Acids, Unsaturated	3-8	nuclear factor kappa B subunit 1	Homo sapiens	114-123
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Fatty Acids, Unsaturated	3-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	124-127
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Fatty Acids, Unsaturated	3-8	interleukin 6	Homo sapiens	130-134
30520776-1	2019	G-protein-coupled receptor 120 (GPR120) plays an important role in regulating lipid and glucose metabolism as a long-chain unsaturated fatty acid receptor.	Fatty Acids, Unsaturated	123-145	free fatty acid receptor 4	Homo sapiens	0-30
30520776-1	2019	G-protein-coupled receptor 120 (GPR120) plays an important role in regulating lipid and glucose metabolism as a long-chain unsaturated fatty acid receptor.	Fatty Acids, Unsaturated	123-145	free fatty acid receptor 4	Homo sapiens	32-38
30578965-0	2019	Free fatty acid receptor 4-beta-arrestin 2 pathway mediates the effects of different classes of unsaturated fatty acids in osteoclasts and osteoblasts.	Fatty Acids, Unsaturated	96-119	arrestin, beta 2	Mus musculus	27-42
30578965-12	2019	This study reveals that FFAR4/betaarr2 signalling may mediate the bone protective effects of different classes of UFAs in osteoclasts and osteoblasts.	Fatty Acids, Unsaturated	114-118	free fatty acid receptor 4	Mus musculus	24-29
31353554-1	2019	The estreification of chrysin with alpha-Linolenic acid (complex I) and linoleic acid (complex II) poly unsaturated fatty acids resulted to design of new mushroom tyrosinase (MT) inhibitors.	Fatty Acids, Unsaturated	99-127	tyrosinase	Homo sapiens	163-173
30578965-12	2019	This study reveals that FFAR4/betaarr2 signalling may mediate the bone protective effects of different classes of UFAs in osteoclasts and osteoblasts.	Fatty Acids, Unsaturated	114-118	arrestin, beta 2	Mus musculus	30-38
29983135-1	2019	Diet supplementation with oilseeds is known to improve the fatty acid profile of meat, but few studies have been carried out to determine the time required for the incorporation of a significant quantity of n-3 polyunsaturated fatty acids (PUFA) into meat from steers.	Fatty Acids, Unsaturated	240-244	PUFA	Bos taurus	211-238
30899527-1	2019	The objective of this meta-analysis was to investigate the effects of plant-derived polyunsaturated fatty acids (PUFAs) on glucose metabolism and insulin resistance.	Fatty Acids, Unsaturated	84-111	insulin	Homo sapiens	146-153
30371807-0	2019	Strong co-suppression impedes an increase in polyunsaturated fatty acids in seeds overexpressing FAD2.	Fatty Acids, Unsaturated	45-72	fatty acid desaturase 2	Arabidopsis thaliana	97-101
30371807-1	2019	Fatty acid desaturase2 (FAD2) catalyses the conversion of oleic acid to linoleic acid and is the main determinant of the levels of essential poly-unsaturated fatty acids (PUFAs) in seed oils.	Fatty Acids, Unsaturated	171-176	fatty acid desaturase 2	Arabidopsis thaliana	0-22
30371807-1	2019	Fatty acid desaturase2 (FAD2) catalyses the conversion of oleic acid to linoleic acid and is the main determinant of the levels of essential poly-unsaturated fatty acids (PUFAs) in seed oils.	Fatty Acids, Unsaturated	171-176	fatty acid desaturase 2	Arabidopsis thaliana	24-28
30511431-2	2019	The major effects were muscle-specific increases in n-3 and n-6 polyunsaturated fatty acids (PUFA) concentrations, resulting in increased accumulation of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).	Fatty Acids, Unsaturated	93-97	Polyunsaturated fatty acid percentage	Sus scrofa	64-91
30347209-1	2019	12-lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of arachidonic acid and other poly-unsaturated fatty acids to both pro- and anti-inflammatory lipid mediators.	Fatty Acids, Unsaturated	120-148	arachidonate 15-lipoxygenase	Homo sapiens	0-15
30347209-1	2019	12-lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of arachidonic acid and other poly-unsaturated fatty acids to both pro- and anti-inflammatory lipid mediators.	Fatty Acids, Unsaturated	120-148	arachidonate 15-lipoxygenase	Homo sapiens	17-23
30818386-3	2019	We describe a novel single nucleotide polymorphism in the Fads2 gene encoding Delta6-desaturase, a key enzyme in the metabolic pathways of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	139-166	fatty acid desaturase 2	Mus musculus	58-63
30818386-3	2019	We describe a novel single nucleotide polymorphism in the Fads2 gene encoding Delta6-desaturase, a key enzyme in the metabolic pathways of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	139-166	fatty acid desaturase 2	Mus musculus	84-95
30813440-2	2019	Omega-3 polyunsaturated fatty acid (PUFA) supplementation is recommended for prevention of chronic disease, and is thought to reduce raised liver fat, yet there have been few randomized controlled trials with accurate measurement of liver fat.	Fatty Acids, Unsaturated	8-34	FAT atypical cadherin 1	Homo sapiens	146-149
30813440-2	2019	Omega-3 polyunsaturated fatty acid (PUFA) supplementation is recommended for prevention of chronic disease, and is thought to reduce raised liver fat, yet there have been few randomized controlled trials with accurate measurement of liver fat.	Fatty Acids, Unsaturated	36-40	FAT atypical cadherin 1	Homo sapiens	24-27
30813440-2	2019	Omega-3 polyunsaturated fatty acid (PUFA) supplementation is recommended for prevention of chronic disease, and is thought to reduce raised liver fat, yet there have been few randomized controlled trials with accurate measurement of liver fat.	Fatty Acids, Unsaturated	36-40	FAT atypical cadherin 1	Homo sapiens	146-149
30343427-7	2019	To relieve lycopene toxicity by increasing unsaturated fatty acid content in cell membranes, the OLE1 gene encoding stearoyl-CoA 9-desaturase was overexpressed.	Fatty Acids, Unsaturated	43-65	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	97-101
30511301-1	2019	The aim of this study was to determine if the dietary pattern of pregnant women has any compensatory effect on the fatty acid desaturase (FADS) gene expression, thus enhancing the conversion of precursors to long chain polyunsaturated fatty acids (LCPUFA) to spare the overall LCPUFA levels.	Fatty Acids, Unsaturated	219-246	stearoyl-CoA desaturase	Homo sapiens	138-142
30761004-3	2019	Accumulating evidence suggests that sEH in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation.	Fatty Acids, Unsaturated	61-88	epoxide hydrolase 2, cytoplasmic	Mus musculus	36-39
30761004-3	2019	Accumulating evidence suggests that sEH in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation.	Fatty Acids, Unsaturated	90-95	epoxide hydrolase 2, cytoplasmic	Mus musculus	36-39
30416039-3	2019	Using solution nuclear magnetic resonance spectroscopy, hydrogen/deuterium exchange mass spectrometry, and molecular dynamics simulations, we show that the putative canonical Nurr1 LBP is dynamic with high solvent accessibility, exchanges between two or more conformations on the microsecond-to-millisecond timescale, and can expand from the collapsed crystallized conformation to allow binding of unsaturated fatty acids.	Fatty Acids, Unsaturated	398-421	nuclear receptor subfamily 4 group A member 2	Homo sapiens	175-180
30416039-3	2019	Using solution nuclear magnetic resonance spectroscopy, hydrogen/deuterium exchange mass spectrometry, and molecular dynamics simulations, we show that the putative canonical Nurr1 LBP is dynamic with high solvent accessibility, exchanges between two or more conformations on the microsecond-to-millisecond timescale, and can expand from the collapsed crystallized conformation to allow binding of unsaturated fatty acids.	Fatty Acids, Unsaturated	398-421	lipopolysaccharide binding protein	Homo sapiens	181-184
30572064-7	2019	Both PUFAs inhibited induction of CYP1 activity in colon cells determined as 7-ethoxyresorufin-O-deethylase (EROD); this was at least partly linked with inhibition of induction of CYP1A1, 1A2 and 1B1 mRNAs.	Fatty Acids, Unsaturated	5-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-38
30572064-7	2019	Both PUFAs inhibited induction of CYP1 activity in colon cells determined as 7-ethoxyresorufin-O-deethylase (EROD); this was at least partly linked with inhibition of induction of CYP1A1, 1A2 and 1B1 mRNAs.	Fatty Acids, Unsaturated	5-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	180-186
30511301-1	2019	The aim of this study was to determine if the dietary pattern of pregnant women has any compensatory effect on the fatty acid desaturase (FADS) gene expression, thus enhancing the conversion of precursors to long chain polyunsaturated fatty acids (LCPUFA) to spare the overall LCPUFA levels.	Fatty Acids, Unsaturated	219-246	stearoyl-CoA desaturase	Homo sapiens	115-136
30761004-0	2019	Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders.	Fatty Acids, Unsaturated	51-56	epoxide hydrolase 2, cytoplasmic	Mus musculus	8-33
30719285-1	2019	Background: Previous research in both calves and other species has suggested n-3 polyunsaturated fatty acids (PUFA) and beta-glucans may have positive effects on immune function.	Fatty Acids, Unsaturated	110-114	PUFA	Bos taurus	81-108
32153916-1	2019	Background: Polyunsaturated fatty acids (PUFAs) have beneficial effects on hypertriglyceridemia although their effect on angiopoietin-like proteins (ANGPTLs), specifically ANGPTL3, ANGPTL4 and ANGPTL8 is unknown.	Fatty Acids, Unsaturated	12-39	angiopoietin like 3	Homo sapiens	172-179
32153916-1	2019	Background: Polyunsaturated fatty acids (PUFAs) have beneficial effects on hypertriglyceridemia although their effect on angiopoietin-like proteins (ANGPTLs), specifically ANGPTL3, ANGPTL4 and ANGPTL8 is unknown.	Fatty Acids, Unsaturated	12-39	angiopoietin like 4	Homo sapiens	181-188
32153916-1	2019	Background: Polyunsaturated fatty acids (PUFAs) have beneficial effects on hypertriglyceridemia although their effect on angiopoietin-like proteins (ANGPTLs), specifically ANGPTL3, ANGPTL4 and ANGPTL8 is unknown.	Fatty Acids, Unsaturated	12-39	angiopoietin like 8	Homo sapiens	193-200
32153916-1	2019	Background: Polyunsaturated fatty acids (PUFAs) have beneficial effects on hypertriglyceridemia although their effect on angiopoietin-like proteins (ANGPTLs), specifically ANGPTL3, ANGPTL4 and ANGPTL8 is unknown.	Fatty Acids, Unsaturated	41-46	angiopoietin like 3	Homo sapiens	172-179
32153916-1	2019	Background: Polyunsaturated fatty acids (PUFAs) have beneficial effects on hypertriglyceridemia although their effect on angiopoietin-like proteins (ANGPTLs), specifically ANGPTL3, ANGPTL4 and ANGPTL8 is unknown.	Fatty Acids, Unsaturated	41-46	angiopoietin like 4	Homo sapiens	181-188
32153916-1	2019	Background: Polyunsaturated fatty acids (PUFAs) have beneficial effects on hypertriglyceridemia although their effect on angiopoietin-like proteins (ANGPTLs), specifically ANGPTL3, ANGPTL4 and ANGPTL8 is unknown.	Fatty Acids, Unsaturated	41-46	angiopoietin like 8	Homo sapiens	193-200
31140173-1	2019	Arachidonic acid (AA) is a polyunsaturated fatty acid that participates in the inflammatory response mainly through bioactive-lipids formation in macrophages and also in the phagocytic NADPH oxidase 2 (NOX2) activation.	Fatty Acids, Unsaturated	27-53	cytochrome b-245 beta chain	Homo sapiens	185-200
31140173-1	2019	Arachidonic acid (AA) is a polyunsaturated fatty acid that participates in the inflammatory response mainly through bioactive-lipids formation in macrophages and also in the phagocytic NADPH oxidase 2 (NOX2) activation.	Fatty Acids, Unsaturated	27-53	cytochrome b-245 beta chain	Homo sapiens	202-206
30563719-0	2019	Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice.	Fatty Acids, Unsaturated	35-61	notch 3	Mus musculus	31-34
31061331-6	2019	The results showed that both ACSL4 variants preferred various kinds of highly unsaturated fatty acids (HUFAs), including docosahexaenoic acid (DHA), adrenic acid (docosatetraenoic acid) and eicosapentaenoic acid (EPA), as well as AA as a substrate.	Fatty Acids, Unsaturated	78-101	acyl-CoA synthetase long chain family member 4	Homo sapiens	29-34
30399404-15	2019	Finally, exploratory analyses suggested that high ACE women with high dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) had a dampened inflammatory response to acute stress, suggesting potentially protective effects of omega-3s in this high-risk population.	Fatty Acids, Unsaturated	125-130	angiotensin I converting enzyme	Homo sapiens	50-53
31984379-2	2019	We hypothesized that saturated fatty acid (SFA) intake, monounsaturated fatty acid (MUFA) and low intake of polyunsaturated fatty acids (PUFA) would be associated with markers of insulin resistance, hyperlipidemia, and hypertriglyceridemia.	Fatty Acids, Unsaturated	108-135	insulin	Homo sapiens	179-186
31984379-2	2019	We hypothesized that saturated fatty acid (SFA) intake, monounsaturated fatty acid (MUFA) and low intake of polyunsaturated fatty acids (PUFA) would be associated with markers of insulin resistance, hyperlipidemia, and hypertriglyceridemia.	Fatty Acids, Unsaturated	137-141	insulin	Homo sapiens	179-186
30535058-0	2019	The Association of Polyunsaturated Fatty Acid delta-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults.	Fatty Acids, Unsaturated	19-45	fatty acid desaturase 1	Homo sapiens	46-64
31543373-1	2019	BACKGROUND: Prestatin trials reported positive effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) in cardiovascular disease, whereas recent studies and meta-analyses have not reproduced these results.	Fatty Acids, Unsaturated	58-93	pumilio RNA binding family member 3	Homo sapiens	99-103
30368227-7	2019	Fads2-/- mice fed an ALA-enriched diet had reduced body weight, little-to-no omega-3 LC-PUFA and a near complete loss of all omega-3 derived oxylipins in both epididymal and inguinal WAT (P&lt;.05) compared to their WT counterparts, as well as altered expression of key regulators of the fatty acid desaturase pathway.	Fatty Acids, Unsaturated	88-92	fatty acid desaturase 2	Mus musculus	0-5
30202902-1	2019	Background: GPR120, a G protein-coupled receptor for long-chain polyunsaturated fatty acids (FAs), mediates the anti-inflammatory effects of omega-3 (omega-3) FAs.	Fatty Acids, Unsaturated	64-91	free fatty acid receptor 4	Mus musculus	12-18
30535058-0	2019	The Association of Polyunsaturated Fatty Acid delta-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults.	Fatty Acids, Unsaturated	19-45	apolipoprotein B	Homo sapiens	135-139
30598703-0	2018	The effects of dietary polyunsaturated fatty acids on miR-126 promoter DNA methylation status and VEGF protein expression in the colorectal cancer cells.	Fatty Acids, Unsaturated	23-50	microRNA 126	Homo sapiens	54-61
29286871-9	2019	This impaired thrombin production paralleled a reduced platelet accumulation within thrombi formed in either small arterioles or larger arteries of mice fed an n-3 PUFA-enriched diet, without impacting P-selectin exposure.	Fatty Acids, Unsaturated	164-168	coagulation factor II	Mus musculus	14-22
30472260-1	2019	12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites.	Fatty Acids, Unsaturated	60-87	arachidonate 15-lipoxygenase	Homo sapiens	0-18
30472260-1	2019	12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites.	Fatty Acids, Unsaturated	60-87	arachidonate 15-lipoxygenase	Homo sapiens	20-29
30391825-7	2019	Unsaturated fatty acid oxidation, insulin response, and oxidative respiration were highly enhanced in Bhlhe40 knockdown or VBH135 over-expressed cells, suggesting the importance of Bhlhe40 in the regulation of unsaturated fatty acid and glucose oxidative metabolism.	Fatty Acids, Unsaturated	0-22	basic helix-loop-helix family member e40	Homo sapiens	102-109
30391825-7	2019	Unsaturated fatty acid oxidation, insulin response, and oxidative respiration were highly enhanced in Bhlhe40 knockdown or VBH135 over-expressed cells, suggesting the importance of Bhlhe40 in the regulation of unsaturated fatty acid and glucose oxidative metabolism.	Fatty Acids, Unsaturated	210-232	basic helix-loop-helix family member e40	Homo sapiens	102-109
30391825-7	2019	Unsaturated fatty acid oxidation, insulin response, and oxidative respiration were highly enhanced in Bhlhe40 knockdown or VBH135 over-expressed cells, suggesting the importance of Bhlhe40 in the regulation of unsaturated fatty acid and glucose oxidative metabolism.	Fatty Acids, Unsaturated	210-232	basic helix-loop-helix family member e40	Homo sapiens	181-188
31454802-2	2019	The PNPLA3 protein functions as an intracellular lipase in the liver, with a greater activity on unsaturated fatty acids.	Fatty Acids, Unsaturated	97-120	patatin like phospholipase domain containing 3	Homo sapiens	4-10
30712664-0	2019	Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array: Induction of xCT/SLC7A11 in human placental BeWo cells.	Fatty Acids, Unsaturated	27-54	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	114-117
30712664-0	2019	Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array: Induction of xCT/SLC7A11 in human placental BeWo cells.	Fatty Acids, Unsaturated	27-54	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	118-125
30712664-7	2019	RESULTS: PUFAs (AA, EPA, and DHA) increased cystine/glutamate transporter xCT/SLC7A11, which mediates the cellular uptake of cystine coupled with the efflux of glutamate in human placental choriocarcinoma BeWo cells.	Fatty Acids, Unsaturated	9-14	solute carrier family 7 member 11	Homo sapiens	74-77
30712664-7	2019	RESULTS: PUFAs (AA, EPA, and DHA) increased cystine/glutamate transporter xCT/SLC7A11, which mediates the cellular uptake of cystine coupled with the efflux of glutamate in human placental choriocarcinoma BeWo cells.	Fatty Acids, Unsaturated	9-14	solute carrier family 7 member 11	Homo sapiens	78-85
30509349-4	2018	Human TLCD1/2 also regulate membrane fluidity by limiting the levels of polyunsaturated fatty acid-containing membrane phospholipids.	Fatty Acids, Unsaturated	72-98	TLC domain containing 1	Homo sapiens	6-13
30558276-1	2018	The enhancement of health-beneficial omega-3 long-chain (&gt;=C20) polyunsaturated fatty acid (n-3 LC-PUFA) contents in the muscle, liver, heart, and kidney of Australian prime lambs through pasture grazing and supplementation with oil infused pellets was investigated.	Fatty Acids, Unsaturated	67-93	PUFA	Ovis aries	102-106
30517876-3	2018	To better address this problem, we developed Fatty Acid Source Analysis (FASA), a model that defines the contribution of synthesis, import, and elongation pathways to fatty acid homeostasis in saturated, monounsaturated, and polyunsaturated fatty acid pools.	Fatty Acids, Unsaturated	225-251	FASA	Homo sapiens	73-77
30184109-0	2018	An omega-3 polyunsaturated fatty acid derivative, 18-HEPE, protects against CXCR4-associated melanoma metastasis.	Fatty Acids, Unsaturated	11-37	chemokine (C-X-C motif) receptor 4	Mus musculus	76-81
30293059-0	2018	Polyunsaturated fatty acid elongation and desaturation in activated human T-cells: ELOVL5 is the key elongase.	Fatty Acids, Unsaturated	0-26	ELOVL fatty acid elongase 5	Homo sapiens	83-89
29547375-1	2018	Previously, polyunsaturated fatty acids (PUFA) from linseed oil were effectively protected (&gt;80%) against biohydrogenation through polyphenol-oxidase-mediated protein crosslinking of an emulsion, prepared with polyphenol oxidase (PPO) extract from potato tuber peelings.	Fatty Acids, Unsaturated	12-39	catechol oxidase B, chloroplastic	Solanum tuberosum	213-231
29547375-1	2018	Previously, polyunsaturated fatty acids (PUFA) from linseed oil were effectively protected (&gt;80%) against biohydrogenation through polyphenol-oxidase-mediated protein crosslinking of an emulsion, prepared with polyphenol oxidase (PPO) extract from potato tuber peelings.	Fatty Acids, Unsaturated	12-39	catechol oxidase B, chloroplastic	Solanum tuberosum	233-236
29547375-1	2018	Previously, polyunsaturated fatty acids (PUFA) from linseed oil were effectively protected (&gt;80%) against biohydrogenation through polyphenol-oxidase-mediated protein crosslinking of an emulsion, prepared with polyphenol oxidase (PPO) extract from potato tuber peelings.	Fatty Acids, Unsaturated	41-45	catechol oxidase B, chloroplastic	Solanum tuberosum	213-231
29547375-1	2018	Previously, polyunsaturated fatty acids (PUFA) from linseed oil were effectively protected (&gt;80%) against biohydrogenation through polyphenol-oxidase-mediated protein crosslinking of an emulsion, prepared with polyphenol oxidase (PPO) extract from potato tuber peelings.	Fatty Acids, Unsaturated	41-45	catechol oxidase B, chloroplastic	Solanum tuberosum	233-236
30453627-1	2018	Fatty acid desaturases (FADS) catalyze the formation of unsaturated fatty acids and have been related to insulin sensitivity (IS).	Fatty Acids, Unsaturated	56-79	insulin	Homo sapiens	105-112
28835115-2	2018	Among them are well-studied eicosanoids and docosanoids that are generated via phospholipase A2 hydrolysis of membrane phospholipids and subsequent oxygenation of free polyunsaturated fatty acids (PUFA) by cyclooxygenases and lipoxygenases.	Fatty Acids, Unsaturated	197-201	phospholipase A2 group IB	Homo sapiens	79-95
30145362-0	2018	miR-146a is involved in the regulation of vertebrate LC-PUFA biosynthesis by targeting elovl5 as demonstrated in rabbitfish Siganus canaliculatus.	Fatty Acids, Unsaturated	56-60	microRNA 146a	Homo sapiens	0-8
30145362-0	2018	miR-146a is involved in the regulation of vertebrate LC-PUFA biosynthesis by targeting elovl5 as demonstrated in rabbitfish Siganus canaliculatus.	Fatty Acids, Unsaturated	56-60	ELOVL fatty acid elongase 5	Homo sapiens	87-93
30475967-11	2018	Participants in the nut group showed an increase in the consumption of total fat, monounsaturated fatty acids, polyunsaturated fatty acids, magnesium, vitamin E, alpha-linolenic acid, total omega-3 (n-3) and omega-3:omega-6 ratio intake during the intervention.	Fatty Acids, Unsaturated	111-138	NUT midline carcinoma family member 1	Homo sapiens	20-23
30400035-2	2018	Fatty acid desaturase 3 (Fads3) belongs to the fatty acid desaturase family, which is a crucial enzyme for highly unsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	114-136	fatty acid desaturase 3	Mus musculus	0-23
30417304-0	2018	Polyunsaturated Fatty Acids and Their Correlations with Parameters of Oxidative/Antioxidant Potential of the Blood and Lipoprotein-Associated Phospholipase A2 in Coronary Atherosclerosis.	Fatty Acids, Unsaturated	0-27	phospholipase A2 group VII	Homo sapiens	119-158
30102092-2	2018	The aim of this meta-analysis was to assess the effect of fish omega-3 polyunsaturated fatty acids (PUFAs) on apo C-III levels.	Fatty Acids, Unsaturated	100-105	apolipoprotein C3	Homo sapiens	110-119
29450735-9	2018	Furthermore, NAC treatment significantly changed fatty acid composition of cells, reducing levels of oleic acid and monounsaturated fatty acids and increasing linoleic acid, n-6, and total polyunsaturated fatty acid (PUFA) proportions.	Fatty Acids, Unsaturated	189-215	X-linked Kx blood group	Homo sapiens	13-16
29450735-9	2018	Furthermore, NAC treatment significantly changed fatty acid composition of cells, reducing levels of oleic acid and monounsaturated fatty acids and increasing linoleic acid, n-6, and total polyunsaturated fatty acid (PUFA) proportions.	Fatty Acids, Unsaturated	217-221	X-linked Kx blood group	Homo sapiens	13-16
30396559-12	2018	In analyses of dietary fat subtypes, AMH decreased with increasing monounsaturated fatty acids (P trend = .082) and polyunsaturated fatty acids (P trend = .043), particularly omega-6 fatty acids (P trend = .044), whereas no strong trend was observed for saturated fatty acids.	Fatty Acids, Unsaturated	116-143	anti-Mullerian hormone	Homo sapiens	37-40
30400035-2	2018	Fatty acid desaturase 3 (Fads3) belongs to the fatty acid desaturase family, which is a crucial enzyme for highly unsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	114-136	fatty acid desaturase 3	Mus musculus	25-30
30555653-0	2018	Effects of Dietary Polyunsaturated Fatty Acids on DNA Methylation and the Expression of DNMT3b and PPARalpha Genes in Rats.	Fatty Acids, Unsaturated	19-46	DNA methyltransferase 3 beta	Rattus norvegicus	88-94
30157033-9	2018	A negative correlation was found between the leptin level and intake of unsaturated fatty acids, protein NAR and meat, poultry and fish consumption in preterm mothers (p&lt;0.05).	Fatty Acids, Unsaturated	72-95	leptin	Homo sapiens	45-51
30333618-9	2018	Electrophysiological analysis of both zebrafish Kcnk2 orthologs shows that, like their human counterparts, they are activated by different physiological stimuli such as mechanical stretch, polyunsaturated fatty acids and intracellular acidification.	Fatty Acids, Unsaturated	189-216	potassium channel, subfamily K, member 2a	Danio rerio	48-53
30241938-8	2018	As the increase of MA is seen as an index of polyunsaturated FA (PUFA) deficiency, and the expression of SCD-1 is suppressed by PUFA, these results strongly suggest that the loss of Reelin leads to PUFA deficiency.	Fatty Acids, Unsaturated	45-63	reelin	Mus musculus	182-188
30241945-12	2018	The findings provide further insight into the structural requirements for PONs substrates and support the hypothesis that PONs, particularly PON1 and PON3, evolved to hydrolyze and regulate a class of lactone lipid mediators derived from polyunsaturated fatty acids.	Fatty Acids, Unsaturated	238-265	paraoxonase 1	Homo sapiens	141-145
30241945-12	2018	The findings provide further insight into the structural requirements for PONs substrates and support the hypothesis that PONs, particularly PON1 and PON3, evolved to hydrolyze and regulate a class of lactone lipid mediators derived from polyunsaturated fatty acids.	Fatty Acids, Unsaturated	238-265	paraoxonase 3	Homo sapiens	150-154
30347644-4	2018	The PUFAs and fish oil formulation completely mitigated or diminished the DEP-induced release of IL-6, IL-8, and ET-1 by 14-78%.	Fatty Acids, Unsaturated	4-9	interleukin 6	Homo sapiens	97-101
30308051-13	2018	In contrast the observed changes in the saturated to mono-unsaturated fatty acid (SFA to MUFA) and saturated to poly-unsaturated fatty acid (SFA to PUFA) ratios in PE P could represent a cellular reaction to counteract this effect by producing more fluid membranes.	Fatty Acids, Unsaturated	112-139	prolyl endopeptidase	Homo sapiens	164-168
28774683-1	2018	BACKGROUND &amp; AIMS: Blood levels of polyunsaturated fatty acids (PUFAs) are under control of endogenous synthesis via Delta5- and Delta6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet.	Fatty Acids, Unsaturated	39-66	fatty acid desaturase 1	Homo sapiens	139-151
28774683-1	2018	BACKGROUND &amp; AIMS: Blood levels of polyunsaturated fatty acids (PUFAs) are under control of endogenous synthesis via Delta5- and Delta6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet.	Fatty Acids, Unsaturated	39-66	fatty acid desaturase 1	Homo sapiens	168-173
30555653-0	2018	Effects of Dietary Polyunsaturated Fatty Acids on DNA Methylation and the Expression of DNMT3b and PPARalpha Genes in Rats.	Fatty Acids, Unsaturated	19-46	peroxisome proliferator activated receptor alpha	Rattus norvegicus	99-108
28774683-1	2018	BACKGROUND &amp; AIMS: Blood levels of polyunsaturated fatty acids (PUFAs) are under control of endogenous synthesis via Delta5- and Delta6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet.	Fatty Acids, Unsaturated	39-66	fatty acid desaturase 2	Homo sapiens	178-183
28774683-1	2018	BACKGROUND &amp; AIMS: Blood levels of polyunsaturated fatty acids (PUFAs) are under control of endogenous synthesis via Delta5- and Delta6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet.	Fatty Acids, Unsaturated	68-73	fatty acid desaturase 1	Homo sapiens	139-151
30208316-0	2018	Mechanisms Underlying the Dual Effect of Polyunsaturated Fatty Acid Analogs on Kv7.1.	Fatty Acids, Unsaturated	41-67	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	79-84
28774683-1	2018	BACKGROUND &amp; AIMS: Blood levels of polyunsaturated fatty acids (PUFAs) are under control of endogenous synthesis via Delta5- and Delta6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet.	Fatty Acids, Unsaturated	68-73	fatty acid desaturase 1	Homo sapiens	168-173
28774683-1	2018	BACKGROUND &amp; AIMS: Blood levels of polyunsaturated fatty acids (PUFAs) are under control of endogenous synthesis via Delta5- and Delta6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet.	Fatty Acids, Unsaturated	68-73	fatty acid desaturase 2	Homo sapiens	178-183
28774683-2	2018	Genome-wide associations studies (GWAS) reported associations between polymorphisms in FADS1-FADS2 and variations in plasma concentrations of PUFAs, HDL- and LDL-cholesterol and triglycerides.	Fatty Acids, Unsaturated	142-147	fatty acid desaturase 1	Homo sapiens	87-92
28774683-2	2018	Genome-wide associations studies (GWAS) reported associations between polymorphisms in FADS1-FADS2 and variations in plasma concentrations of PUFAs, HDL- and LDL-cholesterol and triglycerides.	Fatty Acids, Unsaturated	142-147	fatty acid desaturase 2	Homo sapiens	93-98
30230828-3	2018	In the present study, four CA-4-PUFA conjugates were synthesized by coupling combretastatin A-4 (1) with several polyunsaturated fatty acids.	Fatty Acids, Unsaturated	113-140	carbonic anhydrase 4	Homo sapiens	27-36
30230828-3	2018	In the present study, four CA-4-PUFA conjugates were synthesized by coupling combretastatin A-4 (1) with several polyunsaturated fatty acids.	Fatty Acids, Unsaturated	113-140	carbonic anhydrase 4	Homo sapiens	77-95
30213790-8	2018	CYP77A4 intracellularly localised to the endoplasmic reticulum, which is consistent with the notion that this enzyme acts as an epoxidase of unsaturated fatty acids in the microsomal fraction.	Fatty Acids, Unsaturated	141-164	cytochrome P450, family 77, subfamily A, polypeptide 4	Arabidopsis thaliana	0-7
30213124-2	2018	Endocannabinoids and endocannabinoid-like compounds (endocannabinoid metabolome, ECM) are endogenous lipid mediators derived from long-chain polyunsaturated fatty acids that have been identified in HM.	Fatty Acids, Unsaturated	141-168	multimerin 1	Homo sapiens	81-84
30208316-1	2018	Polyunsaturated fatty acid (PUFA) analogs represent a new class of potential anti-arrhythmic KV7.1 and KV7.1+KCNE1 channel activators.	Fatty Acids, Unsaturated	0-26	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	93-98
30208316-1	2018	Polyunsaturated fatty acid (PUFA) analogs represent a new class of potential anti-arrhythmic KV7.1 and KV7.1+KCNE1 channel activators.	Fatty Acids, Unsaturated	0-26	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	103-108
30208316-1	2018	Polyunsaturated fatty acid (PUFA) analogs represent a new class of potential anti-arrhythmic KV7.1 and KV7.1+KCNE1 channel activators.	Fatty Acids, Unsaturated	0-26	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	109-114
30208316-1	2018	Polyunsaturated fatty acid (PUFA) analogs represent a new class of potential anti-arrhythmic KV7.1 and KV7.1+KCNE1 channel activators.	Fatty Acids, Unsaturated	28-32	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	93-98
30208316-1	2018	Polyunsaturated fatty acid (PUFA) analogs represent a new class of potential anti-arrhythmic KV7.1 and KV7.1+KCNE1 channel activators.	Fatty Acids, Unsaturated	28-32	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	103-108
30208316-1	2018	Polyunsaturated fatty acid (PUFA) analogs represent a new class of potential anti-arrhythmic KV7.1 and KV7.1+KCNE1 channel activators.	Fatty Acids, Unsaturated	28-32	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	109-114
28981381-5	2018	This study aimed to determine the effects of polyunsaturated fatty acid n-3 (PUFA n-3) supplementation on serum leptin levels, appetite sensations, and dietary intakes in obese people.	Fatty Acids, Unsaturated	45-71	pumilio RNA binding family member 3	Homo sapiens	77-81
28981381-5	2018	This study aimed to determine the effects of polyunsaturated fatty acid n-3 (PUFA n-3) supplementation on serum leptin levels, appetite sensations, and dietary intakes in obese people.	Fatty Acids, Unsaturated	45-71	leptin	Homo sapiens	112-118
29858741-3	2018	Eicosanoids, which are metabolites of polyunsaturated fatty acids produced by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes, are important lipid-signaling molecules involved in the regulation of inflammation and tumorigenesis.	Fatty Acids, Unsaturated	38-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	124-139
29858741-3	2018	Eicosanoids, which are metabolites of polyunsaturated fatty acids produced by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes, are important lipid-signaling molecules involved in the regulation of inflammation and tumorigenesis.	Fatty Acids, Unsaturated	38-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	141-144
29882120-3	2018	15-Lipoxygenase (15-LOX) is an enzyme which reacts with polyunsaturated fatty acids and produces metabolites that are implicated in many important human diseases, such as cancer.	Fatty Acids, Unsaturated	56-83	arachidonate 15-lipoxygenase	Homo sapiens	0-15
29702135-11	2018	Taken together, these data suggest that HSWE induces an intrinsic apoptosis, and reduced unsaturated fatty acids by blocking SREBP1 in hepatocellular carcinoma cells.	Fatty Acids, Unsaturated	89-112	sterol regulatory element binding transcription factor 1	Homo sapiens	125-131
29882120-3	2018	15-Lipoxygenase (15-LOX) is an enzyme which reacts with polyunsaturated fatty acids and produces metabolites that are implicated in many important human diseases, such as cancer.	Fatty Acids, Unsaturated	56-83	arachidonate 15-lipoxygenase	Homo sapiens	17-23
29947780-11	2018	Conclusions: Targeted metabolomics identified four plasma amino acids and 16 plasma lipid species, primarily containing polyunsaturated fatty acids, that were associated with abnormal glucose metabolism and insulin resistance in older adults.	Fatty Acids, Unsaturated	120-147	insulin	Homo sapiens	207-214
29702135-0	2018	Zhiheshouwu ethanol extract induces intrinsic apoptosis and reduces unsaturated fatty acids via SREBP1 pathway in hepatocellular carcinoma cells.	Fatty Acids, Unsaturated	68-91	sterol regulatory element binding transcription factor 1	Homo sapiens	96-102
30085078-2	2018	Our previous studies have shown that the regulation of OLE1 in the synthesis of unsaturated fatty acids may act as a positive feedback mechanism to help yeast cells counter the lipid peroxidation and cytoplasmic membrane damage induced by cadmium.	Fatty Acids, Unsaturated	80-103	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	55-59
29627380-1	2018	The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders.	Fatty Acids, Unsaturated	54-81	arachidonate 15-lipoxygenase	Homo sapiens	4-22
30460699-0	2018	Unsaturated Fatty Acids Increase the Expression of Hepassocin through a Signal Transducer and Activator of Transcription 3-Dependent Pathway in HepG2 Cells.	Fatty Acids, Unsaturated	0-23	fibrinogen like 1	Homo sapiens	51-61
30460699-0	2018	Unsaturated Fatty Acids Increase the Expression of Hepassocin through a Signal Transducer and Activator of Transcription 3-Dependent Pathway in HepG2 Cells.	Fatty Acids, Unsaturated	0-23	signal transducer and activator of transcription 3	Homo sapiens	72-122
30007811-14	2018	Concentration and yield of polyunsaturated FA increased and decreased in response to PT and FT, respectively.	Fatty Acids, Unsaturated	27-45	FAT atypical cadherin 1	Bos taurus	92-94
30421529-2	2018	Further studies reported here indicate a role for Cyp2b in unsaturated fatty-acid (UFA) metabolism and in turn obesity.	Fatty Acids, Unsaturated	59-81	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	50-55
30421529-2	2018	Further studies reported here indicate a role for Cyp2b in unsaturated fatty-acid (UFA) metabolism and in turn obesity.	Fatty Acids, Unsaturated	83-86	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	50-55
30421529-12	2018	This suggests that Cyp2b is more than a detoxification enzyme, but also involved in the metabolism of UFA, as Cyp2b-KD mice have increased the body weight, fat deposition, and serum lipids.	Fatty Acids, Unsaturated	102-105	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	19-24
30421529-12	2018	This suggests that Cyp2b is more than a detoxification enzyme, but also involved in the metabolism of UFA, as Cyp2b-KD mice have increased the body weight, fat deposition, and serum lipids.	Fatty Acids, Unsaturated	102-105	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	110-115
29627380-1	2018	The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders.	Fatty Acids, Unsaturated	54-81	arachidonate 15-lipoxygenase	Homo sapiens	24-33
29904174-7	2018	LXR activation preferentially drives the incorporation of polyunsaturated fatty acids into phospholipids by inducing transcription of the remodelling enzyme lysophosphatidylcholine acyltransferase 3.	Fatty Acids, Unsaturated	58-85	lysophosphatidylcholine acyltransferase 3	Homo sapiens	157-198
30197642-1	2018	Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13.	Fatty Acids, Unsaturated	119-146	arachidonate 15-lipoxygenase	Homo sapiens	0-28
30197642-1	2018	Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13.	Fatty Acids, Unsaturated	119-146	arachidonate 15-lipoxygenase	Homo sapiens	30-36
30197642-1	2018	Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13.	Fatty Acids, Unsaturated	119-146	arachidonate 15-lipoxygenase type B	Homo sapiens	42-78
30197642-1	2018	Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13.	Fatty Acids, Unsaturated	119-146	arachidonate 15-lipoxygenase type B	Homo sapiens	80-87
30197642-1	2018	Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13.	Fatty Acids, Unsaturated	119-146	interleukin 4	Homo sapiens	243-256
30197642-1	2018	Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13.	Fatty Acids, Unsaturated	119-146	interleukin 4	Homo sapiens	258-262
30197642-1	2018	Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13.	Fatty Acids, Unsaturated	119-146	interleukin 13	Homo sapiens	271-285
29860127-4	2018	ERCC1-XPF hypomorphic mice were hypersensitive to CCl4 and a diet rich in polyunsaturated fatty acids, two potent inducers of endogenous LPO.	Fatty Acids, Unsaturated	74-101	excision repair cross-complementing rodent repair deficiency, complementation group 1	Mus musculus	0-5
29860127-4	2018	ERCC1-XPF hypomorphic mice were hypersensitive to CCl4 and a diet rich in polyunsaturated fatty acids, two potent inducers of endogenous LPO.	Fatty Acids, Unsaturated	74-101	excision repair cross-complementing rodent repair deficiency, complementation group 4	Mus musculus	6-9
30089836-1	2018	The potential of omega-3 poly-unsaturated fatty acids (PUFAs) as a therapeutic target for psoriasis, a chronic inflammatory skin disease of IL-23/IL-17 axis, is a long-disputed question, since various epidemiological studies have suggested the association between high-intake of omega-3 PUFAs and the reduced frequency and severity of psoriasis.	Fatty Acids, Unsaturated	55-60	interleukin 23, alpha subunit p19	Mus musculus	140-145
30089836-1	2018	The potential of omega-3 poly-unsaturated fatty acids (PUFAs) as a therapeutic target for psoriasis, a chronic inflammatory skin disease of IL-23/IL-17 axis, is a long-disputed question, since various epidemiological studies have suggested the association between high-intake of omega-3 PUFAs and the reduced frequency and severity of psoriasis.	Fatty Acids, Unsaturated	55-60	interleukin 17A	Mus musculus	146-151
32734050-1	2018	In this report, an overview of the health benefits of omega-3 long-chain (>=C20) polyunsaturated fatty acids (n-3 LC-PUFA) and recent progress in using alpha linolenic acid (ALA) rich sources derived from oilseeds to enhance productive performance, n-3 PUFA profiles and sensory properties of lamb for human consumption is reviewed.	Fatty Acids, Unsaturated	81-108	pumilio RNA binding family member 3	Homo sapiens	117-121
28108057-2	2018	Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression.	Fatty Acids, Unsaturated	106-133	phospholipase A2 group IVA	Homo sapiens	0-26
28108057-2	2018	Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression.	Fatty Acids, Unsaturated	106-133	phospholipase A2 group IVA	Homo sapiens	28-33
28108057-2	2018	Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression.	Fatty Acids, Unsaturated	135-140	phospholipase A2 group IVA	Homo sapiens	0-26
28108057-2	2018	Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression.	Fatty Acids, Unsaturated	135-140	phospholipase A2 group IVA	Homo sapiens	28-33
30157936-4	2018	RESULTS: We identified strong associations between single-nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) region and multiple polyunsaturated fatty acids.	Fatty Acids, Unsaturated	146-173	stearoyl-CoA desaturase	Homo sapiens	97-118
30157936-4	2018	RESULTS: We identified strong associations between single-nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) region and multiple polyunsaturated fatty acids.	Fatty Acids, Unsaturated	146-173	stearoyl-CoA desaturase	Homo sapiens	120-124
30118512-6	2018	In this study we screened enzymes in the unsaturated fatty acid (UFA) biosynthetic pathway and found that the rate-limiting enzyme in monounsaturated fatty acid biosynthesis, stearoyl-CoA desaturase 1 (SCD1), is indispensable for DENV2 replication.	Fatty Acids, Unsaturated	41-63	stearoyl-CoA desaturase	Homo sapiens	202-206
30118512-6	2018	In this study we screened enzymes in the unsaturated fatty acid (UFA) biosynthetic pathway and found that the rate-limiting enzyme in monounsaturated fatty acid biosynthesis, stearoyl-CoA desaturase 1 (SCD1), is indispensable for DENV2 replication.	Fatty Acids, Unsaturated	65-68	stearoyl-CoA desaturase	Homo sapiens	202-206
30074985-3	2018	Mfsd2a transports DHA and other polyunsaturated fatty acids (PUFAs) esterified to lysophosphatidylcholine (LPC-DHA).	Fatty Acids, Unsaturated	32-59	major facilitator superfamily domain containing 2A	Mus musculus	0-6
30074985-3	2018	Mfsd2a transports DHA and other polyunsaturated fatty acids (PUFAs) esterified to lysophosphatidylcholine (LPC-DHA).	Fatty Acids, Unsaturated	61-66	major facilitator superfamily domain containing 2A	Mus musculus	0-6
29673706-3	2018	The reacylation is catalyzed by lysophosphatidylcholine acyltransferase (LPCAT), which adds a polyunsaturated fatty acid at the sn-2 position.	Fatty Acids, Unsaturated	94-120	lysophosphatidylcholine acyltransferase 3	Mus musculus	32-71
29673706-3	2018	The reacylation is catalyzed by lysophosphatidylcholine acyltransferase (LPCAT), which adds a polyunsaturated fatty acid at the sn-2 position.	Fatty Acids, Unsaturated	94-120	lysophosphatidylcholine acyltransferase 3	Mus musculus	73-78
29933522-3	2018	In contrast with traditional antioxidants, substituting hydrogen with deuterium at bis-allylic sites in polyunsaturated fatty acids (D-PUFA) decreases the rate-limiting initiation step of PUFA autoxidation, a strategy that has shown benefits in other neurodegenerative diseases.	Fatty Acids, Unsaturated	104-131	pumilio RNA binding family member 3	Homo sapiens	135-139
29933522-3	2018	In contrast with traditional antioxidants, substituting hydrogen with deuterium at bis-allylic sites in polyunsaturated fatty acids (D-PUFA) decreases the rate-limiting initiation step of PUFA autoxidation, a strategy that has shown benefits in other neurodegenerative diseases.	Fatty Acids, Unsaturated	104-131	pumilio RNA binding family member 3	Homo sapiens	188-192
29508404-8	2018	Milk polyunsaturated FA concentrations (total n-3, total n-6, LA and ALNA) and transfer efficiency of LA and ALNA were increased with increasing dietary WC supply.	Fatty Acids, Unsaturated	5-23	Weaning weight-maternal milk	Bos taurus	0-4
30258600-2	2018	The use of very long-chain polyunsaturated fatty acids (VLC PUFA) could potentially benefit individuals with MetS.	Fatty Acids, Unsaturated	27-54	pumilio RNA binding family member 3	Homo sapiens	60-64
29605251-7	2018	Various regulatory aspects of SCD are reviewed in four subsections, i.e., (1) hormonal regulation, (2) regulation by dietary carbohydrates, (3) regulation by green tea, and (4) regulation via polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	192-219	stearoyl-CoA desaturase	Homo sapiens	30-33
29605251-7	2018	Various regulatory aspects of SCD are reviewed in four subsections, i.e., (1) hormonal regulation, (2) regulation by dietary carbohydrates, (3) regulation by green tea, and (4) regulation via polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	221-226	stearoyl-CoA desaturase	Homo sapiens	30-33
30014849-0	2018	KCNE1 tunes the sensitivity of KV7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site.	Fatty Acids, Unsaturated	40-67	potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog	Xenopus laevis	0-5
30014849-0	2018	KCNE1 tunes the sensitivity of KV7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site.	Fatty Acids, Unsaturated	40-67	potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog	Xenopus laevis	31-36
30014849-2	2018	We previously showed that polyunsaturated fatty acids (PUFAs) activate KV7.1 via an electrostatic mechanism.	Fatty Acids, Unsaturated	26-53	potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog	Xenopus laevis	71-76
30014849-2	2018	We previously showed that polyunsaturated fatty acids (PUFAs) activate KV7.1 via an electrostatic mechanism.	Fatty Acids, Unsaturated	55-60	potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog	Xenopus laevis	71-76
30014849-7	2018	We propose that KCNE1 moves the S5-P-helix loop of KV7.1 towards the PUFA-binding site, which indirectly causes PUFA protonation, thereby reducing the effect of PUFAs on KV7.1.	Fatty Acids, Unsaturated	69-73	potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog	Xenopus laevis	16-21
30014849-7	2018	We propose that KCNE1 moves the S5-P-helix loop of KV7.1 towards the PUFA-binding site, which indirectly causes PUFA protonation, thereby reducing the effect of PUFAs on KV7.1.	Fatty Acids, Unsaturated	69-73	potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog	Xenopus laevis	51-56
30014849-7	2018	We propose that KCNE1 moves the S5-P-helix loop of KV7.1 towards the PUFA-binding site, which indirectly causes PUFA protonation, thereby reducing the effect of PUFAs on KV7.1.	Fatty Acids, Unsaturated	69-73	potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog	Xenopus laevis	170-175
28657495-2	2018	The fatty acyl delta6-desaturase (Delta6 desaturase) is a rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids (HUFA) that converts polyunsaturated fatty acids (PUFA) such as linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids into HUFA.	Fatty Acids, Unsaturated	117-140	fatty acid desaturase 2	Homo sapiens	15-32
28657495-2	2018	The fatty acyl delta6-desaturase (Delta6 desaturase) is a rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids (HUFA) that converts polyunsaturated fatty acids (PUFA) such as linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids into HUFA.	Fatty Acids, Unsaturated	117-140	fatty acid desaturase 2	Homo sapiens	40-51
28657495-2	2018	The fatty acyl delta6-desaturase (Delta6 desaturase) is a rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids (HUFA) that converts polyunsaturated fatty acids (PUFA) such as linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids into HUFA.	Fatty Acids, Unsaturated	162-189	fatty acid desaturase 2	Homo sapiens	15-32
28657495-2	2018	The fatty acyl delta6-desaturase (Delta6 desaturase) is a rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids (HUFA) that converts polyunsaturated fatty acids (PUFA) such as linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids into HUFA.	Fatty Acids, Unsaturated	162-189	fatty acid desaturase 2	Homo sapiens	40-51
28657495-2	2018	The fatty acyl delta6-desaturase (Delta6 desaturase) is a rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids (HUFA) that converts polyunsaturated fatty acids (PUFA) such as linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids into HUFA.	Fatty Acids, Unsaturated	191-195	fatty acid desaturase 2	Homo sapiens	15-32
28657495-2	2018	The fatty acyl delta6-desaturase (Delta6 desaturase) is a rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids (HUFA) that converts polyunsaturated fatty acids (PUFA) such as linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids into HUFA.	Fatty Acids, Unsaturated	191-195	fatty acid desaturase 2	Homo sapiens	40-51
30050886-2	2018	Due to a key role in the metabolism of unsaturated fatty acids such as arachidonic acid, one of the most important precursors of immunity mediators, fatty acid desaturase (FADS) genes could have an important impact in the development of type 2 diabetes.	Fatty Acids, Unsaturated	39-62	stearoyl-CoA desaturase	Homo sapiens	149-170
29777706-2	2018	N-3 polyunsaturated fatty acids (PUFAs) have been used to improve clinical outcomes of patients receiving PN; however, the mechanisms by which n-3 PUFAs ameliorate hepatic steatosis remain unclear.	Fatty Acids, Unsaturated	33-38	notch 3	Mus musculus	0-3
29749565-6	2018	Recent developments in the area with a focus on the production of polyunsaturated fatty acids from marine bacteria as well as the metabolic engineering strategies for the improvement of PUFA production are discussed.	Fatty Acids, Unsaturated	66-93	pumilio RNA binding family member 3	Homo sapiens	186-190
29514873-8	2018	We also found novel significant experiment-wise SNP associations with: polyunsaturated fatty acid (PUFA) 6/PUFA3 ratio (sorting nexin 29), eicosenoic (intergenic) and capric (component of oligomeric Golgi complex 3) acids; and six additional loci at genomewide significance (&lt;5x10-8).	Fatty Acids, Unsaturated	71-97	sorting nexin 29	Homo sapiens	120-136
29514873-8	2018	We also found novel significant experiment-wise SNP associations with: polyunsaturated fatty acid (PUFA) 6/PUFA3 ratio (sorting nexin 29), eicosenoic (intergenic) and capric (component of oligomeric Golgi complex 3) acids; and six additional loci at genomewide significance (&lt;5x10-8).	Fatty Acids, Unsaturated	99-103	sorting nexin 29	Homo sapiens	120-136
29869888-1	2018	Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids.	Fatty Acids, Unsaturated	101-124	stearoyl-CoA desaturase	Homo sapiens	0-23
29869888-1	2018	Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids.	Fatty Acids, Unsaturated	101-124	stearoyl-CoA desaturase	Homo sapiens	25-28
30050886-2	2018	Due to a key role in the metabolism of unsaturated fatty acids such as arachidonic acid, one of the most important precursors of immunity mediators, fatty acid desaturase (FADS) genes could have an important impact in the development of type 2 diabetes.	Fatty Acids, Unsaturated	39-62	stearoyl-CoA desaturase	Homo sapiens	172-176
30123865-12	2018	Conclusion: Higher spermatozoa G6PD activity in October, where the level of polyunsaturated fatty acids is suggested to be increased, may reflect the increased need of nicotinamide adenine dinucleotide phosphate and thus higher G6PD activity for the oxidative balance.	Fatty Acids, Unsaturated	76-103	glucose-6-phosphate dehydrogenase	Homo sapiens	31-35
29546268-3	2018	One of the key enzymes involved in the metabolism of polyunsaturated fatty acids to 4HNE in somatic cells is arachidonate 15-lipoxygenase (ALOX15).	Fatty Acids, Unsaturated	53-80	arachidonate 15-lipoxygenase	Homo sapiens	109-137
29546268-3	2018	One of the key enzymes involved in the metabolism of polyunsaturated fatty acids to 4HNE in somatic cells is arachidonate 15-lipoxygenase (ALOX15).	Fatty Acids, Unsaturated	53-80	arachidonate 15-lipoxygenase	Homo sapiens	139-145
29627385-3	2018	OLE1 expression is tightly regulated to adapt UFA biosynthesis and lipid bilayer properties to changes in temperature, and in UFA or oxygen availability.	Fatty Acids, Unsaturated	46-49	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
29627385-3	2018	OLE1 expression is tightly regulated to adapt UFA biosynthesis and lipid bilayer properties to changes in temperature, and in UFA or oxygen availability.	Fatty Acids, Unsaturated	126-129	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
29627385-6	2018	Cells lacking MGA2 display low UFA levels and do not grow under iron-limited conditions, unless UFAs are supplemented or OLE1 is overexpressed.	Fatty Acids, Unsaturated	31-34	Mga2p	Saccharomyces cerevisiae S288C	14-18
29899324-2	2018	Recently, we reported that fat-1 mice, which can convert n-6 to n-3 polyunsaturated fatty acids (PUFAs), are protected against allergic airway inflammation because their Th2 immune responses are suppressed.	Fatty Acids, Unsaturated	97-102	FAT atypical cadherin 1	Mus musculus	27-32
29899324-2	2018	Recently, we reported that fat-1 mice, which can convert n-6 to n-3 polyunsaturated fatty acids (PUFAs), are protected against allergic airway inflammation because their Th2 immune responses are suppressed.	Fatty Acids, Unsaturated	97-102	heart and neural crest derivatives expressed 2	Mus musculus	170-173
29704509-6	2018	Thus it responds to endogenous medium and long chain unsaturated fatty acids, resulting in enhancement of insulin secretion during increased glucose levels.	Fatty Acids, Unsaturated	53-76	insulin	Homo sapiens	106-113
30123865-12	2018	Conclusion: Higher spermatozoa G6PD activity in October, where the level of polyunsaturated fatty acids is suggested to be increased, may reflect the increased need of nicotinamide adenine dinucleotide phosphate and thus higher G6PD activity for the oxidative balance.	Fatty Acids, Unsaturated	76-103	glucose-6-phosphate dehydrogenase	Homo sapiens	228-232
29546329-15	2018	Assessment of the hyperbolic relationship between insulin sensitivity and secretion through the disposition index revealed a distinctive signature of polyunsaturated fatty acids (P = 1.55 x 10-12 to 5.81 x 10-6; R2adj = 3.8%) beyond that of its component measures.	Fatty Acids, Unsaturated	150-177	insulin	Homo sapiens	50-57
29682966-5	2018	The percentages of C18:1omega-9c, C18:2omega-6c, C18:3omega-3, and polyunsaturated fatty acid (PUFA) in the longissimus thoracis muscle were increased in the PGZ + CrMet group.	Fatty Acids, Unsaturated	67-93	Polyunsaturated fatty acid percentage	Sus scrofa	95-99
29623357-10	2018	Furthermore, enrichment of lipid raft entities with poly-unsaturated fatty acids (PUFA) rescued A549 cells from CSE-mediated membrane recruitment of NLRP10 and NLRP12, and also from inflammatory responses and inflammasome activation.	Fatty Acids, Unsaturated	52-80	NLR family pyrin domain containing 10	Homo sapiens	149-155
29623357-10	2018	Furthermore, enrichment of lipid raft entities with poly-unsaturated fatty acids (PUFA) rescued A549 cells from CSE-mediated membrane recruitment of NLRP10 and NLRP12, and also from inflammatory responses and inflammasome activation.	Fatty Acids, Unsaturated	52-80	NLR family pyrin domain containing 12	Homo sapiens	160-166
29623357-10	2018	Furthermore, enrichment of lipid raft entities with poly-unsaturated fatty acids (PUFA) rescued A549 cells from CSE-mediated membrane recruitment of NLRP10 and NLRP12, and also from inflammatory responses and inflammasome activation.	Fatty Acids, Unsaturated	82-86	NLR family pyrin domain containing 10	Homo sapiens	149-155
29623357-10	2018	Furthermore, enrichment of lipid raft entities with poly-unsaturated fatty acids (PUFA) rescued A549 cells from CSE-mediated membrane recruitment of NLRP10 and NLRP12, and also from inflammatory responses and inflammasome activation.	Fatty Acids, Unsaturated	82-86	NLR family pyrin domain containing 12	Homo sapiens	160-166
29477476-7	2018	Cell-type specific differences in expression of DNMT1, DNMT3a, and 3b genes were also observed between PUFA-treated and control cells (p &lt; 0.05).	Fatty Acids, Unsaturated	103-107	DNA methyltransferase 3 alpha	Homo sapiens	55-61
29477476-7	2018	Cell-type specific differences in expression of DNMT1, DNMT3a, and 3b genes were also observed between PUFA-treated and control cells (p &lt; 0.05).	Fatty Acids, Unsaturated	103-107	DNA methyltransferase 1	Homo sapiens	48-53
29477537-2	2018	Contents of short-chain, medium-chain, long-chain, saturated, and unsaturated fatty acid groupings in milk samples can be predicted using mid-infrared spectral data for cows enrolled in milk recording programs.	Fatty Acids, Unsaturated	66-88	Weaning weight-maternal milk	Bos taurus	102-106
29892158-0	2018	Modification of alpha-synuclein by lipid peroxidation products derived from polyunsaturated fatty acids promotes toxic oligomerization: its relevance to Parkinson disease.	Fatty Acids, Unsaturated	76-103	synuclein alpha	Homo sapiens	16-31
29892158-2	2018	alpha-Synuclein interacts with membrane lipids especially polyunsaturated fatty acids to stabilize its three-dementional structure.	Fatty Acids, Unsaturated	58-85	synuclein alpha	Homo sapiens	0-15
29892158-3	2018	Peroxidation of polyunsaturated fatty acids may reduce their affinity to alpha-synuclein and peroxidation byproducts might modify alpha-synuclein.	Fatty Acids, Unsaturated	16-43	synuclein alpha	Homo sapiens	73-88
29892158-10	2018	Accumulation of abnormal alpha-synuclein modified by lipid radicals derived from polyunsaturated fatty acids may be not only an indicator of brain oxidative stress but also causative of neurodegeneration such as Parkinson disease by impairing mitochondrial function.	Fatty Acids, Unsaturated	81-108	synuclein alpha	Homo sapiens	25-40
29477537-2	2018	Contents of short-chain, medium-chain, long-chain, saturated, and unsaturated fatty acid groupings in milk samples can be predicted using mid-infrared spectral data for cows enrolled in milk recording programs.	Fatty Acids, Unsaturated	66-88	Weaning weight-maternal milk	Bos taurus	186-190
29461797-1	2018	The 12/15-lipoxygenase (12/15-LOX) enzyme introduces peroxyl groups, in a position-specific manner, into polyunsaturated fatty acids to form various kinds of bioactive lipid metabolites, including lipid-derived electrophiles (LDE).	Fatty Acids, Unsaturated	105-132	arachidonate 15-lipoxygenase	Mus musculus	4-22
30053283-0	2018	Diets Low in Saturated Fat with Different Unsaturated Fatty Acid Profiles Similarly Increase Serum-Mediated Cholesterol Efflux from THP-1 Macrophages in a Population with or at Risk for Metabolic Syndrome: The Canola Oil Multicenter Intervention Trial.	Fatty Acids, Unsaturated	42-64	GLI family zinc finger 2	Homo sapiens	132-137
29543379-10	2018	A lipidomics analysis revealed that HDL2 from ACS patients had more oxidized polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	77-104	junctophilin 3	Homo sapiens	36-40
29552684-11	2018	n-3 PUFA-rich oil diets, particularly the fish oil diet, reduced the plasma levels of nonesterified fatty acids, tumor necrosis factor-alpha, and brain dopamine and RAGE expression but not glycemic status, resulting in an improvement in the time of escape latency and the time spent in the target quadrant in the MWM test.	Fatty Acids, Unsaturated	4-8	advanced glycosylation end product-specific receptor	Rattus norvegicus	165-169
29461797-1	2018	The 12/15-lipoxygenase (12/15-LOX) enzyme introduces peroxyl groups, in a position-specific manner, into polyunsaturated fatty acids to form various kinds of bioactive lipid metabolites, including lipid-derived electrophiles (LDE).	Fatty Acids, Unsaturated	105-132	arachidonate 15-lipoxygenase	Mus musculus	24-33
29636834-1	2018	Background: Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels.	Fatty Acids, Unsaturated	140-166	stearoyl-CoA desaturase	Homo sapiens	40-61
29636834-1	2018	Background: Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels.	Fatty Acids, Unsaturated	140-166	stearoyl-CoA desaturase	Homo sapiens	63-67
29636834-1	2018	Background: Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels.	Fatty Acids, Unsaturated	168-172	stearoyl-CoA desaturase	Homo sapiens	40-61
29636834-1	2018	Background: Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels.	Fatty Acids, Unsaturated	168-172	stearoyl-CoA desaturase	Homo sapiens	63-67
29636834-1	2018	Background: Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels.	Fatty Acids, Unsaturated	258-262	stearoyl-CoA desaturase	Homo sapiens	40-61
29636834-1	2018	Background: Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels.	Fatty Acids, Unsaturated	258-262	stearoyl-CoA desaturase	Homo sapiens	63-67
29615666-5	2018	Notably, significant upregulation of genes involved in unsaturated fatty acid metabolism [stearoyl-CoA desaturase (SCD)] and cholesterol biosynthesis [3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)], were associated with atorvastatin insensitivity.	Fatty Acids, Unsaturated	55-77	stearoyl-CoA desaturase	Homo sapiens	90-113
29615666-5	2018	Notably, significant upregulation of genes involved in unsaturated fatty acid metabolism [stearoyl-CoA desaturase (SCD)] and cholesterol biosynthesis [3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)], were associated with atorvastatin insensitivity.	Fatty Acids, Unsaturated	55-77	stearoyl-CoA desaturase	Homo sapiens	115-118
29615666-5	2018	Notably, significant upregulation of genes involved in unsaturated fatty acid metabolism [stearoyl-CoA desaturase (SCD)] and cholesterol biosynthesis [3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)], were associated with atorvastatin insensitivity.	Fatty Acids, Unsaturated	55-77	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	151-191
29615666-5	2018	Notably, significant upregulation of genes involved in unsaturated fatty acid metabolism [stearoyl-CoA desaturase (SCD)] and cholesterol biosynthesis [3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)], were associated with atorvastatin insensitivity.	Fatty Acids, Unsaturated	55-77	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	193-198
28793941-6	2018	The contents of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) were 41.64%, 56.24% and 2.10%, respectively, and the MUFA/SFA ratio, PUFA/SFA ratio, desaturation index (DI) and elongation index (EI) were 1.36, 0.05, 0.59 and 0.66, respectively.	Fatty Acids, Unsaturated	86-113	PUFA	Bos taurus	115-119
29381485-4	2018	Pharmacological and genetic XBP1 inhibition induces Myc-dependent apoptosis, which is alleviated by exogenous unsaturated fatty acids.	Fatty Acids, Unsaturated	110-133	X-box binding protein 1	Homo sapiens	28-32
29381485-4	2018	Pharmacological and genetic XBP1 inhibition induces Myc-dependent apoptosis, which is alleviated by exogenous unsaturated fatty acids.	Fatty Acids, Unsaturated	110-133	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	52-55
29358223-1	2018	Background: Marine omega-3 polyunsaturated fatty acids (PUFAs), primarily found in dark fish, may prevent colorectal cancer progression, in part through inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2).	Fatty Acids, Unsaturated	56-61	prostaglandin-endoperoxide synthase 2	Homo sapiens	206-211
29383568-8	2018	However, the cellular lipid constitution of Deltasso2 was richer in unsaturated fatty acids than the wild type, indicating that Sso2p is associated with lipid homeostasis of the plasma membrane.	Fatty Acids, Unsaturated	68-91	syntaxin	Saccharomyces cerevisiae S288C	128-133
29556240-0	2018	Polyunsaturated Fatty Acid Biosynthesis Involving Delta8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells.	Fatty Acids, Unsaturated	0-26	fatty acid desaturase 2	Homo sapiens	106-111
29481633-7	2018	SLP1 cells supplemented with polyunsaturated fatty acids decreased cell thermotolerance and increased the degree of lipoperoxidation, while arachidic acid addition exhibited a tendency to increase yeast thermotolerance.	Fatty Acids, Unsaturated	29-56	Slp1p	Saccharomyces cerevisiae S288C	0-4
29998870-7	2018	Results: In men, IL-6 had a significant (P &lt;0.05) positive association with total omega-3 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	122-127	interleukin 6	Homo sapiens	17-21
29998870-8	2018	In women, TNF-alpha had a significant positive association with total omega-3 (P &lt;0.05) and omega-6 (P &lt;0.01) PUFAs, IL-6 had a significant (P &lt;0.05) positive association with total monounsaturated fatty acids and MCP-1 had a significant positive association with total trans-fatty acids (P &lt;0.05).	Fatty Acids, Unsaturated	116-121	tumor necrosis factor	Homo sapiens	10-19
29978130-8	2018	A positive correlation was found between the contents of SigmaDDT and saturated and polyunsaturated fatty acids and SigmaSFA and SigmaPUFA in cow milk fat, and C18:2c9c12 in mare milk fat.	Fatty Acids, Unsaturated	84-111	Weaning weight-maternal milk	Bos taurus	146-150
29538286-6	2018	Dietary omega 3 polyunsaturated fatty acids (PUFA) have been suggested to counteract insulin resistance development by modulating mitochondrial bioenergetics and ER stress.	Fatty Acids, Unsaturated	16-43	insulin	Homo sapiens	85-92
29538286-6	2018	Dietary omega 3 polyunsaturated fatty acids (PUFA) have been suggested to counteract insulin resistance development by modulating mitochondrial bioenergetics and ER stress.	Fatty Acids, Unsaturated	45-49	insulin	Homo sapiens	85-92
29436695-11	2018	high-n-3 PUFA diet promoted autophagy ability and inhibited activity of the mTORC1 signaling pathway compared with the low-n-3 PUFA diet group or the control group (P&lt;0.05).	Fatty Acids, Unsaturated	9-13	CREB regulated transcription coactivator 1	Mus musculus	76-82
29534042-5	2018	Changes in polyunsaturated fatty acids in milk and cheese due to pasture diets has been suggested may increase susceptibility to lipid oxidation but does not seem to be an issue to due increased antioxidants and the reducing environment of cheese.	Fatty Acids, Unsaturated	11-38	Weaning weight-maternal milk	Bos taurus	42-46
29237573-11	2018	Collectively, these findings for the first time reveal the differential regulation of various SCDs by distinct cytochrome b5 CYTB-5.1 and CYTB-5.2 in the biosynthesis of UFAs in C. elegans.	Fatty Acids, Unsaturated	170-174	Cytochrome b5 heme-binding domain-containing protein	Caenorhabditis elegans	125-133
29229414-4	2018	We found that hGX sPLA2 releases a mixture of unsaturated FAs, including omega-3 and omega-6 polyunsaturated FAs (PUFAs), from TNBC cells.	Fatty Acids, Unsaturated	46-61	phospholipase A2 group X	Homo sapiens	18-23
29237573-11	2018	Collectively, these findings for the first time reveal the differential regulation of various SCDs by distinct cytochrome b5 CYTB-5.1 and CYTB-5.2 in the biosynthesis of UFAs in C. elegans.	Fatty Acids, Unsaturated	170-174	Cytochrome b5 heme-binding domain-containing protein	Caenorhabditis elegans	138-146
29458553-10	2018	A change in lipid composition was confirmed using Raman spectroscopy, which showed that the ppm1- mutant had a greater relative proportion of unsaturated fatty acids compared to the parent or the complemented mutant.	Fatty Acids, Unsaturated	142-165	leucine carboxy methyltransferase	Saccharomyces cerevisiae S288C	92-96
28649761-4	2018	Expression of DGAT1 from Arabidopsis thaliana effectively increased total fatty acids by 1.81-fold above control, and ROD1 led to increased unsaturated fatty acid content of yeast lipid.	Fatty Acids, Unsaturated	140-162	membrane bound O-acyl transferase (MBOAT) family protein	Arabidopsis thaliana	14-19
28649761-4	2018	Expression of DGAT1 from Arabidopsis thaliana effectively increased total fatty acids by 1.81-fold above control, and ROD1 led to increased unsaturated fatty acid content of yeast lipid.	Fatty Acids, Unsaturated	140-162	phosphatidic acid phosphatase-related / PAP2-like protein	Arabidopsis thaliana	118-122
29229294-1	2018	Polyunsaturated fatty acids omega-3 (n-3 PUFA), such as docosahexaenoic acid (DHA), have been shown to prevent, and partially reverse, neurotoxin-induced nigrostriatal denervation in animal models of Parkinson"s disease (PD).	Fatty Acids, Unsaturated	0-27	pumilio RNA binding family member 3	Homo sapiens	41-45
29190548-0	2018	Supplementation with polyunsaturated fatty acids in pregnant rats with mild diabetes normalizes placental PPARgamma and mTOR signaling in female offspring developing gestational diabetes.	Fatty Acids, Unsaturated	21-48	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	106-115
29190548-0	2018	Supplementation with polyunsaturated fatty acids in pregnant rats with mild diabetes normalizes placental PPARgamma and mTOR signaling in female offspring developing gestational diabetes.	Fatty Acids, Unsaturated	21-48	mechanistic target of rapamycin kinase	Rattus norvegicus	120-124
29663401-10	2018	The current study revealed that, after adjustment for energy intake, the AA genotype of PPARGC1A (rs11290186) had a direct association with polyunsaturated fatty acids and linoleic acid intakes.	Fatty Acids, Unsaturated	140-167	PPARG coactivator 1 alpha	Homo sapiens	88-96
29398618-2	2018	Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (AA), but the in vivo actions of ACSL4 are unknown.	Fatty Acids, Unsaturated	98-116	acyl-CoA synthetase long-chain family member 4	Mus musculus	0-32
29398618-2	2018	Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (AA), but the in vivo actions of ACSL4 are unknown.	Fatty Acids, Unsaturated	98-116	acyl-CoA synthetase long-chain family member 4	Mus musculus	34-39
29398618-2	2018	Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (AA), but the in vivo actions of ACSL4 are unknown.	Fatty Acids, Unsaturated	98-116	acyl-CoA synthetase long-chain family member 4	Mus musculus	185-190
29398618-2	2018	Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (AA), but the in vivo actions of ACSL4 are unknown.	Fatty Acids, Unsaturated	118-122	acyl-CoA synthetase long-chain family member 4	Mus musculus	0-32
29398618-2	2018	Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (AA), but the in vivo actions of ACSL4 are unknown.	Fatty Acids, Unsaturated	118-122	acyl-CoA synthetase long-chain family member 4	Mus musculus	34-39
29398618-2	2018	Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (AA), but the in vivo actions of ACSL4 are unknown.	Fatty Acids, Unsaturated	118-122	acyl-CoA synthetase long-chain family member 4	Mus musculus	185-190
29521623-1	2018	The thermal hydrolysis of saturated (C16:0 and C18:0) and unsaturated fatty acids (C16:1, C18:1, and C18:2) was investigated at 90  C to 160  C for 30 min and 8 h durations.	Fatty Acids, Unsaturated	58-81	Bardet-Biedl syndrome 9	Homo sapiens	90-93
29235036-1	2018	The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) is enriched in neural membranes of the CNS, and recent studies have shown a role of DHA metabolism by 15-lipoxygenase-1 (Alox15) in prefrontal cortex resolvin D1 formation, hippocampo-prefrontal cortical long-term-potentiation, spatial working memory, and anti-nociception/anxiety.	Fatty Acids, Unsaturated	12-38	arachidonate 15-lipoxygenase	Homo sapiens	188-194
29080699-3	2018	CYP enzymes, previously identified as arachidonic acid (20:4n-6; AA) epoxygenases, accept eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA), the major fish oil n-3 LC-PUFAs, as efficient alternative substrates.	Fatty Acids, Unsaturated	194-199	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
29452256-1	2018	Polyunsaturated fatty acids (PUFA"s) are majorly classified as omega-3 and omega-6 fatty acids.	Fatty Acids, Unsaturated	0-27	pumilio RNA binding family member 3	Homo sapiens	29-33
29521623-1	2018	The thermal hydrolysis of saturated (C16:0 and C18:0) and unsaturated fatty acids (C16:1, C18:1, and C18:2) was investigated at 90  C to 160  C for 30 min and 8 h durations.	Fatty Acids, Unsaturated	58-81	Bardet-Biedl syndrome 9	Homo sapiens	90-93
28462631-11	2018	KEY MESSAGES Serum high-sensitivity C-reactive protein (hsCRP) concentration is positively associated with sugar intake, and negatively with the consumption of minerals, vitamins and polyunsaturated fatty-acids (fruit and vegetables).	Fatty Acids, Unsaturated	183-210	C-reactive protein	Homo sapiens	36-54
29353041-1	2018	Fatty acid desaturase 2 (FADS2) is responsible for the first desaturation reaction in the synthesis of highly unsaturated fatty acids (HUFAs), such as arachidonic acid (20:4n-6) and eicosapentaenoic acid (20:5n-3), and is involved in Mead acid (20:3n-9) production during essential fatty acid deficiency (EFAD).	Fatty Acids, Unsaturated	110-133	fatty acid desaturase 2	Mus musculus	0-23
29353041-1	2018	Fatty acid desaturase 2 (FADS2) is responsible for the first desaturation reaction in the synthesis of highly unsaturated fatty acids (HUFAs), such as arachidonic acid (20:4n-6) and eicosapentaenoic acid (20:5n-3), and is involved in Mead acid (20:3n-9) production during essential fatty acid deficiency (EFAD).	Fatty Acids, Unsaturated	110-133	fatty acid desaturase 2	Mus musculus	25-30
29549917-1	2018	We aimed to evaluate the longitudinal interaction effects between the minor allele of FADS1 rs174547 and overweight on n-3 and n-6 long-chain polyunsaturated fatty acid (PUFA) levels and pulse wave velocity (PWV).	Fatty Acids, Unsaturated	170-174	fatty acid desaturase 1	Homo sapiens	86-91
29466985-9	2018	Among those with insulin resistance there was a positive association between monounsaturated fatty acids and arachidonic fatty acid and adiponectin (p &lt; 0.05), and a negative association between monounsaturated and polyunsaturated fatty acids and pro-inflammatory biomarkers (p &lt; 0.05), as well as a negative association between polyunsaturated fatty acids and adiponectin (p &lt; 0.05).	Fatty Acids, Unsaturated	218-245	insulin	Homo sapiens	17-24
29466985-11	2018	CONCLUSIONS: Subjects in secondary prevention for cardiovascular disease with insulin resistance have a higher concentration of hs-CRP and IL-6 than individuals without insulin resistance, and these inflammatory biomarkers are positively associated with saturated fatty acids and negatively associated with unsaturated fatty acids.	Fatty Acids, Unsaturated	307-330	insulin	Homo sapiens	78-85
29330355-3	2018	The essential fatty acid linoleic acid is crucial for the structure of the epidermal barrier, while polyunsaturated fatty acids act as precursors to eicosanoids, octadecanoids and docosanoids through cyclooxygenase, lipoxygenase and cytochrome P450 monooxygenase-mediated reactions, and endocannabinoids and N-acyl ethanolamines.	Fatty Acids, Unsaturated	100-127	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	233-262
28161092-2	2018	In addition, the results of randomized controlled trials (RCTs) in relation to the effects of n-3 polyunsaturated fatty acid (PUFA) supplementation on alanine aminotransferase (ALT), aspartate aminotransferase (AST), liver fat, triglyceride (TAG) and fasting glucose levels are inconsistent.	Fatty Acids, Unsaturated	126-130	glutamic--pyruvic transaminase	Homo sapiens	151-175
29087622-10	2018	Polyunsaturated fatty acids and dietary fiber inversely correlate with insulin, HOMA-IR, and triglycerides.	Fatty Acids, Unsaturated	0-27	insulin	Homo sapiens	71-78
29417145-5	2018	STGD occurs due to altered synthesis of very long-chain polyunsaturated fatty acids (VLC-PUFA).	Fatty Acids, Unsaturated	56-83	pumilio RNA binding family member 3	Homo sapiens	89-93
29573267-1	2018	The aim of this study was to determine the effect of n3 polyunsaturated fatty acids (PUFA) on canine adipose tissue secretion of adiponectin, interleukin-6 (IL6), and tumor necrosis factor-alpha (TNFalpha).	Fatty Acids, Unsaturated	85-89	adiponectin, C1Q and collagen domain containing	Canis lupus familiaris	129-140
29573267-1	2018	The aim of this study was to determine the effect of n3 polyunsaturated fatty acids (PUFA) on canine adipose tissue secretion of adiponectin, interleukin-6 (IL6), and tumor necrosis factor-alpha (TNFalpha).	Fatty Acids, Unsaturated	85-89	interleukin 6	Canis lupus familiaris	142-155
29876402-3	2018	We have also discovered EPHX2-associated eicosanoids derived from polyunsaturated fatty acids to be aberrant in patients with anorexia nervosa, suggesting that genetically moderated lipid metabolism may be an underlying factor in AN pathogenesis.	Fatty Acids, Unsaturated	66-93	epoxide hydrolase 2	Homo sapiens	24-29
28986132-3	2018	Inflammation resolution is an active process controlled by lipidic specialized pro-resolving mediators (SPMs), derived from omega-3 or omega-6 essential polyunsaturated fatty acids (PUFA) through the activity of lipoxygenases (ALOX5 and 15).	Fatty Acids, Unsaturated	182-186	arachidonate 5-lipoxygenase	Homo sapiens	227-232
28962890-14	2018	The GC-MS analysis results showed that RhA contained a large number of unsaturated fatty acids, such as octadecadienoic acid (linoleic acid), octadecatrienoic acid (linolenic acid), and oleate, which might represent the anticancer components of the extract.	Fatty Acids, Unsaturated	71-94	HCL2	Homo sapiens	39-42
29293603-5	2018	We observed a reduction of total phosphatidylcholine-containing very long chain-polyunsaturated fatty acids (PC-VLC-PUFAs) by 39% in the R91W;Nrl-/-;Elovl4 mice already at 6 weeks of age with a pronounced decline of the longest forms of PC-VLC-PUFAs.	Fatty Acids, Unsaturated	80-107	neural retina leucine zipper gene	Mus musculus	142-145
28775155-7	2018	The generated NADPH is also an essential cofactor across other peroxisomal pathways, including the antioxidant ascorbate-glutathione cycle and unsaturated fatty acid beta-oxidation, the latter being a source of powerful signaling molecules such as JA and NO2-FA.	Fatty Acids, Unsaturated	143-165	2,4-dienoyl-CoA reductase 1	Homo sapiens	14-19
29287723-6	2018	Functional characterizations of loach elovl4a and elovl4b on synthesis of fatty acids, especially elongating C18 polyunsaturated fatty acids (PUFAs) to longer-chain fatty acids, were studied by heterologous expression in Saccharomyces cerevisiae.	Fatty Acids, Unsaturated	142-147	ELOVL fatty acid elongase 4a	Danio rerio	38-45
29287723-6	2018	Functional characterizations of loach elovl4a and elovl4b on synthesis of fatty acids, especially elongating C18 polyunsaturated fatty acids (PUFAs) to longer-chain fatty acids, were studied by heterologous expression in Saccharomyces cerevisiae.	Fatty Acids, Unsaturated	142-147	ELOVL fatty acid elongase 4b	Danio rerio	50-57
29158261-9	2018	However, BPL-1 disruption strongly decreased levels of polyunsaturated fatty acids in embryos produced by bpl-1 mutant hermaphrodites, revealing a critical role for BPL-1 in lipid biosynthesis during embryogenesis and demonstrating that dietary fatty acids and lipid precursors are not adequate to support early embryogenesis in the absence of BPL-1.	Fatty Acids, Unsaturated	55-82	BPL/LPL catalytic domain-containing protein	Caenorhabditis elegans	9-14
29158261-9	2018	However, BPL-1 disruption strongly decreased levels of polyunsaturated fatty acids in embryos produced by bpl-1 mutant hermaphrodites, revealing a critical role for BPL-1 in lipid biosynthesis during embryogenesis and demonstrating that dietary fatty acids and lipid precursors are not adequate to support early embryogenesis in the absence of BPL-1.	Fatty Acids, Unsaturated	55-82	BPL/LPL catalytic domain-containing protein	Caenorhabditis elegans	106-111
29188717-7	2018	Because membrane-residing PUFA phospholipids can undergo oxidation and form reactive species under increased levels of oxidative stress, we hypothesized that incorporation of PUFAs into PUFA-TAGs and their localization within lipid droplets during apoptosis limit the toxicity during this process.	Fatty Acids, Unsaturated	175-180	pumilio RNA binding family member 3	Homo sapiens	26-30
29188717-8	2018	Indeed, exogenous delivery of a polyunsaturated fatty acid resulted in a profound accumulation of PUFA phospholipids and rendered cells more sensitive to oxidative stress, causing reduced viability.	Fatty Acids, Unsaturated	32-58	pumilio RNA binding family member 3	Homo sapiens	98-102
30034876-6	2018	Previously, it was suggested that polyunsaturated fatty acids (PUFAs): linoleic, alpha-linolenic, gamma-linolenic (GLA), dihomo-GLA (DGLA), arachidonic (AA), eicosapentaenoic (EPA), and docosahexaenoic acids (DHA) function as endogenous anti-bacterial, anti-fungal, anti-viral, anti-parasitic, and immunomodulating agents.	Fatty Acids, Unsaturated	34-61	galactosidase alpha	Homo sapiens	81-119
30034876-6	2018	Previously, it was suggested that polyunsaturated fatty acids (PUFAs): linoleic, alpha-linolenic, gamma-linolenic (GLA), dihomo-GLA (DGLA), arachidonic (AA), eicosapentaenoic (EPA), and docosahexaenoic acids (DHA) function as endogenous anti-bacterial, anti-fungal, anti-viral, anti-parasitic, and immunomodulating agents.	Fatty Acids, Unsaturated	63-68	galactosidase alpha	Homo sapiens	81-119
29293603-5	2018	We observed a reduction of total phosphatidylcholine-containing very long chain-polyunsaturated fatty acids (PC-VLC-PUFAs) by 39% in the R91W;Nrl-/-;Elovl4 mice already at 6 weeks of age with a pronounced decline of the longest forms of PC-VLC-PUFAs.	Fatty Acids, Unsaturated	80-107	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	149-155
30092569-1	2018	OBJECTIVE: The aim of this study was to analyze dietary omega-6:omega-3 polyunsaturated fatty acid (PUFA) ratio and its association with adiposity and serum adiponectin levels in a Mexican population.	Fatty Acids, Unsaturated	100-104	adiponectin, C1Q and collagen domain containing	Homo sapiens	157-168
29044636-10	2018	Serum resistin was inversely associated with n-3 polyunsaturated fatty acids (PUFA) intake after adjustment for age, sex, BMI and energy intake (Q1 12.5, Q2 12.5, Q3 12.2, Q4 11.5 ng/mL; P for trend = .007).	Fatty Acids, Unsaturated	78-82	resistin	Homo sapiens	6-14
30170993-1	2018	BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Delta5- and Delta6-desaturases (encoded by the FADS1 and FADS2 genes, respectively).	Fatty Acids, Unsaturated	18-44	fatty acid desaturase 1	Homo sapiens	132-144
30170993-1	2018	BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Delta5- and Delta6-desaturases (encoded by the FADS1 and FADS2 genes, respectively).	Fatty Acids, Unsaturated	18-44	fatty acid desaturase 1	Homo sapiens	161-166
30170993-1	2018	BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Delta5- and Delta6-desaturases (encoded by the FADS1 and FADS2 genes, respectively).	Fatty Acids, Unsaturated	18-44	fatty acid desaturase 2	Homo sapiens	171-176
30170993-1	2018	BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Delta5- and Delta6-desaturases (encoded by the FADS1 and FADS2 genes, respectively).	Fatty Acids, Unsaturated	46-50	fatty acid desaturase 1	Homo sapiens	132-144
30170993-1	2018	BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Delta5- and Delta6-desaturases (encoded by the FADS1 and FADS2 genes, respectively).	Fatty Acids, Unsaturated	46-50	fatty acid desaturase 1	Homo sapiens	161-166
30170993-1	2018	BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Delta5- and Delta6-desaturases (encoded by the FADS1 and FADS2 genes, respectively).	Fatty Acids, Unsaturated	46-50	fatty acid desaturase 2	Homo sapiens	171-176
28985138-1	2018	OBJECTIVE: Soy milk is enriched with nutritive elements such as proteins, unsaturated fatty acids, lecithins, isoflavones, mineral substances, free amino acids, and polypeptides.	Fatty Acids, Unsaturated	74-97	Weaning weight-maternal milk	Bos taurus	15-19
29129703-3	2018	The recessive, X-linked TAZ gene encodes a mitochondrial membrane-associated phospholipid modifying enzyme, which adds unsaturated fatty acid species to monolysocardiolipin to generate mature cardiolipin in the mitochondrial membrane that is essential for mitochondrial morphology and function.	Fatty Acids, Unsaturated	119-141	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	24-27
28723414-6	2018	We also provide an in-depth rationale for the use of dietary omega3 polyunsaturated fatty acid (omega3 PUFA) supplements as a treatment option for NAFLD.	Fatty Acids, Unsaturated	68-94	pumilio RNA binding family member 3	Homo sapiens	103-107
29913106-2	2018	G-protein coupled receptor (GPR) 40 has been identified as a receptor of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	73-100	free fatty acid receptor 1	Homo sapiens	0-35
29577851-2	2018	In vitro observations have shown that specific brain-enriched polyunsaturated fatty acids, such as arachidonic acid, can give rise to a conformational change in alpha-synuclein and ultimately induce its fibrillation.	Fatty Acids, Unsaturated	62-89	synuclein alpha	Homo sapiens	161-176
29800597-7	2018	Nut components, such as unsaturated fatty acids, l-arginine, beneficial minerals, phenolic compounds and phytosterols, appear to be of paramount importance for their health effects.	Fatty Acids, Unsaturated	24-47	NUT midline carcinoma family member 1	Homo sapiens	0-3
29282029-1	2017	BACKGROUND: Fatty acid synthase (FASN), the major enzyme in de novo fatty acid synthesis, is highly expressed in breast cancer and its expression is reduced by polyunsaturated fatty acids (PUFAs) in liver.	Fatty Acids, Unsaturated	160-187	fatty acid synthase	Homo sapiens	12-31
29282129-8	2017	PCA uncovered three DPs which accounted for 56.8% of the variance in dietary nutrients consumption including DP1 (fatty acids and cholesterol), DP2 (minerals, vitamins and fiber), and DP3 (polyunsaturated fatty acids [PUFA]).	Fatty Acids, Unsaturated	189-216	APC regulator of WNT signaling pathway	Homo sapiens	184-187
29282029-1	2017	BACKGROUND: Fatty acid synthase (FASN), the major enzyme in de novo fatty acid synthesis, is highly expressed in breast cancer and its expression is reduced by polyunsaturated fatty acids (PUFAs) in liver.	Fatty Acids, Unsaturated	160-187	fatty acid synthase	Homo sapiens	33-37
29282029-1	2017	BACKGROUND: Fatty acid synthase (FASN), the major enzyme in de novo fatty acid synthesis, is highly expressed in breast cancer and its expression is reduced by polyunsaturated fatty acids (PUFAs) in liver.	Fatty Acids, Unsaturated	189-194	fatty acid synthase	Homo sapiens	12-31
29282029-1	2017	BACKGROUND: Fatty acid synthase (FASN), the major enzyme in de novo fatty acid synthesis, is highly expressed in breast cancer and its expression is reduced by polyunsaturated fatty acids (PUFAs) in liver.	Fatty Acids, Unsaturated	189-194	fatty acid synthase	Homo sapiens	33-37
28972163-7	2017	Although degradation of mouse stearoyl-CoA desaturase 1 (SCD1) was unaffected by changes in fatty acid unsaturation, introduction of the N-terminal sequential proline residues into SCD1 conferred responsiveness to unsaturated fatty acid-dependent degradation.	Fatty Acids, Unsaturated	214-236	stearoyl-Coenzyme A desaturase 1	Mus musculus	30-55
29228005-9	2017	At the transcriptome level, we found substantial changes in genes involved in fatty acid metabolism and the biosynthesis of unsaturated fatty acids, such as stearoyl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydratase 2, ELOVL fatty acid elongase 6 and fatty acid synthase, suggesting that the expression levels of these genes may be directly regulated by MSTN and that these genes are likely downstream targets of MSTN with potential roles in lipid metabolism in goats.	Fatty Acids, Unsaturated	124-147	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2	Capra hircus	185-216
29228005-9	2017	At the transcriptome level, we found substantial changes in genes involved in fatty acid metabolism and the biosynthesis of unsaturated fatty acids, such as stearoyl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydratase 2, ELOVL fatty acid elongase 6 and fatty acid synthase, suggesting that the expression levels of these genes may be directly regulated by MSTN and that these genes are likely downstream targets of MSTN with potential roles in lipid metabolism in goats.	Fatty Acids, Unsaturated	124-147	growth/differentiation factor 8	Capra hircus	353-357
29228005-9	2017	At the transcriptome level, we found substantial changes in genes involved in fatty acid metabolism and the biosynthesis of unsaturated fatty acids, such as stearoyl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydratase 2, ELOVL fatty acid elongase 6 and fatty acid synthase, suggesting that the expression levels of these genes may be directly regulated by MSTN and that these genes are likely downstream targets of MSTN with potential roles in lipid metabolism in goats.	Fatty Acids, Unsaturated	124-147	growth/differentiation factor 8	Capra hircus	412-416
28972163-7	2017	Although degradation of mouse stearoyl-CoA desaturase 1 (SCD1) was unaffected by changes in fatty acid unsaturation, introduction of the N-terminal sequential proline residues into SCD1 conferred responsiveness to unsaturated fatty acid-dependent degradation.	Fatty Acids, Unsaturated	214-236	stearoyl-Coenzyme A desaturase 1	Mus musculus	181-185
28972163-3	2017	In this study, we found that the degradation of DESAT1, the sole Delta9-desaturase in the Drosophila cell line S2, was significantly enhanced when the amounts of unsaturated acyl chains of membrane phospholipids were increased by supplementation with unsaturated fatty acids, such as oleic and linoleic acids.	Fatty Acids, Unsaturated	251-274	Desaturase 1	Drosophila melanogaster	48-54
28972163-9	2017	In light of these findings, we designated the sequential prolines at the second and third positions of DESAT1 as a "di-proline motif," which plays a crucial role in the regulation of Delta9-desaturase expression in response to changes in the level of cellular unsaturated fatty acids.	Fatty Acids, Unsaturated	260-283	Desaturase 1	Drosophila melanogaster	103-109
28972163-6	2017	Further truncation and amino acid replacement analyses revealed that two sequential prolines, the second and third residues of DESAT1, were responsible for the unsaturated fatty acid-dependent degradation.	Fatty Acids, Unsaturated	160-182	Desaturase 1	Drosophila melanogaster	127-133
28847514-4	2017	In this study, the fat-1 transgenic mice that synthesizes endogenous n-3 from n-6 PUFA and their wild type littermates with an exogenous n-3 PUFA enriched diet were subjected to a chronic ethanol feeding plus a single binge as model to induce liver injury with adipose lipolysis.	Fatty Acids, Unsaturated	82-86	FAT atypical cadherin 1	Mus musculus	19-24
28972104-5	2017	Specifically, alpha6beta4-mediated activation of Src and STAT3 suppresses expression of ACSL4, an enzyme that enriches membranes with long polyunsaturated fatty acids and is required for ferroptosis.	Fatty Acids, Unsaturated	139-166	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-52
28972104-5	2017	Specifically, alpha6beta4-mediated activation of Src and STAT3 suppresses expression of ACSL4, an enzyme that enriches membranes with long polyunsaturated fatty acids and is required for ferroptosis.	Fatty Acids, Unsaturated	139-166	signal transducer and activator of transcription 3	Homo sapiens	57-62
28972104-5	2017	Specifically, alpha6beta4-mediated activation of Src and STAT3 suppresses expression of ACSL4, an enzyme that enriches membranes with long polyunsaturated fatty acids and is required for ferroptosis.	Fatty Acids, Unsaturated	139-166	acyl-CoA synthetase long chain family member 4	Homo sapiens	88-93
29285172-5	2017	Furthermore, n-3 PUFA treatment effectively reversed the cardiac dysfunction and dilatation observed in symptomatic H/M-Sod2-/- mice.	Fatty Acids, Unsaturated	17-21	superoxide dismutase 2, mitochondrial	Mus musculus	120-124
29285172-6	2017	Notably, n-3 PUFA treatment ameliorated a molecular defect in connexin 43.	Fatty Acids, Unsaturated	13-17	gap junction protein, alpha 1	Mus musculus	62-73
28551025-2	2017	CYP isoforms metabolize a number of n-3 and n-6 polyunsaturated fatty acids (PUFA), including linoleic acid (18:2n6, LA), arachidonic acid (20:4n6, AA), ecosapentaenoic acid (20:5n3, EPA) and docosahexaenoic acid (22:6n3, DHA) into bioactive lipid mediators, termed eicosanoids.	Fatty Acids, Unsaturated	77-81	peptidylprolyl isomerase G	Homo sapiens	0-3
29156156-1	2017	This study focused on the effect of polyunsaturated fatty acids (PUFAs) during the lactation period of delta-6-desaturase knockout (D6D-KO) mice using an artificial rearing method.	Fatty Acids, Unsaturated	36-63	fatty acid desaturase 2	Mus musculus	103-121
29156156-1	2017	This study focused on the effect of polyunsaturated fatty acids (PUFAs) during the lactation period of delta-6-desaturase knockout (D6D-KO) mice using an artificial rearing method.	Fatty Acids, Unsaturated	65-70	fatty acid desaturase 2	Mus musculus	103-121
28891336-3	2017	Folic acid (FA)-conjugated PUFA-based lipid nanoparticles (FA-PLN/DTX) was developed.	Fatty Acids, Unsaturated	27-31	phospholamban	Homo sapiens	62-65
28918153-7	2017	The DGAT1 KK genotype was associated with a lower proportion of polyunsaturated fatty acids in milk fat, and with a higher milk fat and protein content, and proportion of saturated fatty acids in milk fat compared with the DGAT1 AA genotype, whereas the fat- and protein-corrected milk yield was unaffected by DGAT1.	Fatty Acids, Unsaturated	64-91	diacylglycerol O-acyltransferase 1	Bos taurus	4-9
28946784-7	2017	At both baseline and week 8, brain-derived neurotrophic factor level had a negative association with polyunsaturated fatty acids and a positive association with saturated fatty acids and monounsaturated fatty acids.	Fatty Acids, Unsaturated	101-128	brain derived neurotrophic factor	Homo sapiens	29-62
28972610-2	2017	This study aimed to investigate whether fat-1 transgenic mice with a higher tissue content of n-3 polyunsaturated fatty acids (PUFAs) could prevent HFS diet-induced NAFLD, compared with wild-type mice.	Fatty Acids, Unsaturated	127-132	FAT atypical cadherin 1	Mus musculus	40-45
28402022-10	2017	In addition, StAR overexpression increased serum unsaturated fatty acids (UFAs) and PPARgamma expression in muscle and adipose tissue of obese mice.	Fatty Acids, Unsaturated	49-72	steroidogenic acute regulatory protein	Mus musculus	13-17
28402022-10	2017	In addition, StAR overexpression increased serum unsaturated fatty acids (UFAs) and PPARgamma expression in muscle and adipose tissue of obese mice.	Fatty Acids, Unsaturated	74-78	steroidogenic acute regulatory protein	Mus musculus	13-17
28402022-11	2017	In conclusion, StAR may activate PPARgamma by increasing UFAs, which leads to a protective role in systemic inflammation and insulin resistance in obese mice.	Fatty Acids, Unsaturated	57-61	steroidogenic acute regulatory protein	Mus musculus	15-19
28402022-11	2017	In conclusion, StAR may activate PPARgamma by increasing UFAs, which leads to a protective role in systemic inflammation and insulin resistance in obese mice.	Fatty Acids, Unsaturated	57-61	peroxisome proliferator activated receptor gamma	Mus musculus	33-42
29031395-6	2017	Besides, a significant negative association of PUFA, n-6, and n-9 fatty acids with leptin mRNA from visceral adipose tissue were observed.	Fatty Acids, Unsaturated	47-51	leptin	Homo sapiens	83-89
28442442-1	2017	Polyunsaturated fatty acids (PUFA) and their cytochrome P450 (CYP450) metabolites have been linked to angiogenesis and vessel homeostasis.	Fatty Acids, Unsaturated	0-27	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	62-68
28442442-1	2017	Polyunsaturated fatty acids (PUFA) and their cytochrome P450 (CYP450) metabolites have been linked to angiogenesis and vessel homeostasis.	Fatty Acids, Unsaturated	29-33	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	62-68
29079824-0	2017	WRKY43 regulates polyunsaturated fatty acid content and seed germination under unfavourable growth conditions.	Fatty Acids, Unsaturated	17-43	WRKY DNA-binding protein 43	Arabidopsis thaliana	0-6
29079824-4	2017	Biochemical analysis of fatty acid composition revealed that loss of WRKY43 increased polyunsaturated fatty acid content in seeds, particularly 18:2Delta9,12 and 18:3Delta9,12,15 in triacylglycerols and phospholipids, indicating an important physiological effect on fatty acid desaturation with ramifications for the tolerance of plants to cold and osmotic stress and possibly, for oilseed engineering.	Fatty Acids, Unsaturated	86-112	WRKY DNA-binding protein 43	Arabidopsis thaliana	69-75
28984836-5	2017	Fat-1 transgenic mice had a decrease in the omega-6/omega-3 polyunsaturated fatty acids (PUFAs) ratio as compared with C57BL/6 wild-type mice (56%, p &lt; 0.001).	Fatty Acids, Unsaturated	89-94	FAT atypical cadherin 1	Mus musculus	0-5
29065507-6	2017	Moreover, polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) are effective at limiting the hepatic steatosis process through a series of biochemical events, such as reducing the markers of non-alcoholic hepatic steatosis, increasing the gene expression of lipid metabolism, decreasing lipogenic activity, and releasing adiponectin.	Fatty Acids, Unsaturated	10-37	adiponectin, C1Q and collagen domain containing	Homo sapiens	344-355
29065507-6	2017	Moreover, polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) are effective at limiting the hepatic steatosis process through a series of biochemical events, such as reducing the markers of non-alcoholic hepatic steatosis, increasing the gene expression of lipid metabolism, decreasing lipogenic activity, and releasing adiponectin.	Fatty Acids, Unsaturated	39-44	adiponectin, C1Q and collagen domain containing	Homo sapiens	344-355
29065507-7	2017	This current review shows that the consumption of unsaturated fatty acids, MUFA, and PUFA, and especially EPA and DHA, which can be applied as food supplements, may promote effects on glucose and lipid metabolism, as well as on metabolic inflammation, gut microbiota, and hepatic metabolism.	Fatty Acids, Unsaturated	50-73	pumilio RNA binding family member 3	Homo sapiens	85-89
29048366-8	2017	The highest incorporation of PUFA was 45.6%; including 36.8% DHA and 5.8% EPA at the following reaction conditions: hexane; 55  C; PUFA-EF/PC acyl ratio of 10; 48 h of reaction time and lipase B from Candida antarctica as a biocatalyst (20% of enzyme load).	Fatty Acids, Unsaturated	29-33	PAN0_003d1715	Moesziomyces antarcticus	186-192
28803985-9	2017	Moreover, miR-199a-3p regulates fatty acid composition by decreasing the ratio of unsaturated fatty acids (UFAs) in adipocytes transfected with miR-199a-3p mimics.	Fatty Acids, Unsaturated	82-105	microRNA 615	Mus musculus	10-13
28803985-9	2017	Moreover, miR-199a-3p regulates fatty acid composition by decreasing the ratio of unsaturated fatty acids (UFAs) in adipocytes transfected with miR-199a-3p mimics.	Fatty Acids, Unsaturated	82-105	microRNA 615	Mus musculus	144-147
28803985-9	2017	Moreover, miR-199a-3p regulates fatty acid composition by decreasing the ratio of unsaturated fatty acids (UFAs) in adipocytes transfected with miR-199a-3p mimics.	Fatty Acids, Unsaturated	107-111	microRNA 615	Mus musculus	10-13
28803985-9	2017	Moreover, miR-199a-3p regulates fatty acid composition by decreasing the ratio of unsaturated fatty acids (UFAs) in adipocytes transfected with miR-199a-3p mimics.	Fatty Acids, Unsaturated	107-111	microRNA 615	Mus musculus	144-147
28846071-6	2017	Furthermore, induction of the phospholipid-remodeling enzyme LPCAT3 in response to liver X receptor (LXR) activation promoted SREBP-1c processing by driving the incorporation of polyunsaturated fatty acids into ER.	Fatty Acids, Unsaturated	178-205	lysophosphatidylcholine acyltransferase 3	Homo sapiens	61-67
28846071-6	2017	Furthermore, induction of the phospholipid-remodeling enzyme LPCAT3 in response to liver X receptor (LXR) activation promoted SREBP-1c processing by driving the incorporation of polyunsaturated fatty acids into ER.	Fatty Acids, Unsaturated	178-205	sterol regulatory element binding transcription factor 1	Homo sapiens	126-134
28976605-1	2017	OBJECTIVE: Spinocerebellar ataxia 38 (SCA38) is caused by mutations in the ELOVL5 gene, which encodes an elongase involved in the synthesis of polyunsaturated fatty acids, including docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	143-170	ELOVL fatty acid elongase 5	Homo sapiens	11-36
29078847-2	2017	We investigated the effect of resveratrol and omega-3-line polyunsaturated fatty acid on surtuin 1 (SIRT1) gene expression in human monocytes (THP1) cells.	Fatty Acids, Unsaturated	59-85	sirtuin 1	Homo sapiens	100-105
28976605-1	2017	OBJECTIVE: Spinocerebellar ataxia 38 (SCA38) is caused by mutations in the ELOVL5 gene, which encodes an elongase involved in the synthesis of polyunsaturated fatty acids, including docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	143-170	ELOVL fatty acid elongase 5	Homo sapiens	38-43
28976605-1	2017	OBJECTIVE: Spinocerebellar ataxia 38 (SCA38) is caused by mutations in the ELOVL5 gene, which encodes an elongase involved in the synthesis of polyunsaturated fatty acids, including docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	143-170	ELOVL fatty acid elongase 5	Homo sapiens	75-81
28687611-3	2017	A screening campaign revealed retinol (vitamin A alcohol) and all-trans retinoic acid (vitamin A acid) (RA) as hits that time-dependently (&gt;=24 h) deplete phosphatidylcholine-bound polyunsaturated fatty acids (PUFA-PCs) from NIH-3T3 mouse fibroblasts while inducing Akt activation (EC50   0.1-1 microM).	Fatty Acids, Unsaturated	184-211	thymoma viral proto-oncogene 1	Mus musculus	269-272
28739279-7	2017	The other tested PUFAs, DPA, docosahexaenoic acid (DHA) (C22:6 n-3), and AA, were also able to reduce ABCA1 functionality while the monounsaturated oleic FA slightly decreased efflux and the saturated palmitic FA had no impact.	Fatty Acids, Unsaturated	17-22	ATP binding cassette subfamily A member 1	Homo sapiens	102-107
28688796-7	2017	Both apoE3 and apoE4 increased saturated and monounsaturated fatty acids (SFA and MUFA), omega-6/omega-3 ratio and decreased total polyunsaturated fatty acid (PUFA) amount, but with various intensities.	Fatty Acids, Unsaturated	131-157	apolipoprotein E	Homo sapiens	5-10
28688796-7	2017	Both apoE3 and apoE4 increased saturated and monounsaturated fatty acids (SFA and MUFA), omega-6/omega-3 ratio and decreased total polyunsaturated fatty acid (PUFA) amount, but with various intensities.	Fatty Acids, Unsaturated	131-157	apolipoprotein E	Homo sapiens	15-20
28688796-7	2017	Both apoE3 and apoE4 increased saturated and monounsaturated fatty acids (SFA and MUFA), omega-6/omega-3 ratio and decreased total polyunsaturated fatty acid (PUFA) amount, but with various intensities.	Fatty Acids, Unsaturated	159-163	apolipoprotein E	Homo sapiens	5-10
28688796-7	2017	Both apoE3 and apoE4 increased saturated and monounsaturated fatty acids (SFA and MUFA), omega-6/omega-3 ratio and decreased total polyunsaturated fatty acid (PUFA) amount, but with various intensities.	Fatty Acids, Unsaturated	159-163	apolipoprotein E	Homo sapiens	15-20
28411302-6	2017	Chloroplast C-16 and C-18 polyunsaturated FA were more affected by phosphate than C-20 and C-22 highly unsaturated FA (HUFA).	Fatty Acids, Unsaturated	26-44	Bardet-Biedl syndrome 9	Homo sapiens	21-25
28411302-6	2017	Chloroplast C-16 and C-18 polyunsaturated FA were more affected by phosphate than C-20 and C-22 highly unsaturated FA (HUFA).	Fatty Acids, Unsaturated	30-44	Bardet-Biedl syndrome 9	Homo sapiens	21-25
28987722-1	2017	The aim of this work was: to assess the impact of diets enriched in polyunsaturated fatty acids omega-3 and omega-6 families on the lipid profile of cell membrane and their effect on cycle regulation and apoptosis, evaluated by TP53 and Ki-67 expression in 9,10-dimethyl-1,2-benzanthracene (DMBA) induced tumor development in submandibular glands (SMG) in murine models.	Fatty Acids, Unsaturated	68-95	transformation related protein 53	Mus musculus	228-232
28912452-5	2017	Topical application of docosahexaenoic acid (DHA), a representative omega-3 PUFA, in wild type hairless mice induced expression of the Nrf2 target protein, heme oxygenase-1 in the skin and protected against UVB-induced oxidative stress, inflammation and papillomagenesis.	Fatty Acids, Unsaturated	76-80	nuclear factor, erythroid derived 2, like 2	Mus musculus	135-139
28912452-5	2017	Topical application of docosahexaenoic acid (DHA), a representative omega-3 PUFA, in wild type hairless mice induced expression of the Nrf2 target protein, heme oxygenase-1 in the skin and protected against UVB-induced oxidative stress, inflammation and papillomagenesis.	Fatty Acids, Unsaturated	76-80	heme oxygenase 1	Mus musculus	156-172
28894242-5	2017	Acylcarnitines elevation, polyunsaturated fatty acids (PUFA) lower levels, and monounsaturated fatty acids (MUFA) upregulation characterize the individual overexpression of ACSL1, ACSL4 and SCD, respectively.	Fatty Acids, Unsaturated	26-53	acyl-CoA synthetase long chain family member 1	Homo sapiens	173-178
29037332-2	2017	We hypothesized that increasing PUFA intake in mice would increase peroxisome proliferator activated receptor delta (PPARdelta) expression and activity, and we sought to examine the effect of different PUFA-enriched oils on muscle PPARdelta expression.	Fatty Acids, Unsaturated	32-36	peroxisome proliferator activator receptor delta	Mus musculus	117-126
28717005-6	2017	Oxidized vesicles containing both phosphatidylserine and polyunsaturated fatty acids were required to promote inactivation of the ZPI-PZ complex or free ZPI, indicating that binding of the PZ-complexed or free ZPI to peroxide-modified phospholipid vesicles mediates the inactivation.	Fatty Acids, Unsaturated	57-84	serpin family A member 10	Homo sapiens	130-133
28717005-6	2017	Oxidized vesicles containing both phosphatidylserine and polyunsaturated fatty acids were required to promote inactivation of the ZPI-PZ complex or free ZPI, indicating that binding of the PZ-complexed or free ZPI to peroxide-modified phospholipid vesicles mediates the inactivation.	Fatty Acids, Unsaturated	57-84	serpin family A member 10	Homo sapiens	153-156
28717005-6	2017	Oxidized vesicles containing both phosphatidylserine and polyunsaturated fatty acids were required to promote inactivation of the ZPI-PZ complex or free ZPI, indicating that binding of the PZ-complexed or free ZPI to peroxide-modified phospholipid vesicles mediates the inactivation.	Fatty Acids, Unsaturated	57-84	serpin family A member 10	Homo sapiens	153-156
28729463-1	2017	Dietary PUFAs reduce atherosclerosis and macrophage inflammation, but how nucleotide-binding oligomerization domain leucine-rich repeat-containing receptor protein (NLRP3) inflammasome activation and autophagy influence PUFA-mediated atheroprotection is poorly understood.	Fatty Acids, Unsaturated	8-13	NLR family, pyrin domain containing 3	Mus musculus	165-170
28729463-1	2017	Dietary PUFAs reduce atherosclerosis and macrophage inflammation, but how nucleotide-binding oligomerization domain leucine-rich repeat-containing receptor protein (NLRP3) inflammasome activation and autophagy influence PUFA-mediated atheroprotection is poorly understood.	Fatty Acids, Unsaturated	8-12	NLR family, pyrin domain containing 3	Mus musculus	165-170
28894242-5	2017	Acylcarnitines elevation, polyunsaturated fatty acids (PUFA) lower levels, and monounsaturated fatty acids (MUFA) upregulation characterize the individual overexpression of ACSL1, ACSL4 and SCD, respectively.	Fatty Acids, Unsaturated	55-59	acyl-CoA synthetase long chain family member 1	Homo sapiens	173-178
28251657-8	2017	Capsaicin and unsaturated fatty acid PSO can activate and improve the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and peroxisome proliferators-activated receptors (PPARalpha).	Fatty Acids, Unsaturated	14-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	89-134
28251657-8	2017	Capsaicin and unsaturated fatty acid PSO can activate and improve the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and peroxisome proliferators-activated receptors (PPARalpha).	Fatty Acids, Unsaturated	14-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	136-141
28251657-8	2017	Capsaicin and unsaturated fatty acid PSO can activate and improve the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and peroxisome proliferators-activated receptors (PPARalpha).	Fatty Acids, Unsaturated	14-36	peroxisome proliferator activated receptor alpha	Rattus norvegicus	193-202
28827783-6	2017	Interestingly, CCDC3, as a secreted protein, targets liver cancer cells and increases long chain polyunsaturated fatty acids, but decreases ceramide in the cells.	Fatty Acids, Unsaturated	97-124	coiled-coil domain containing 3	Mus musculus	15-20
28919798-0	2017	Comparative effects of the omega3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain.	Fatty Acids, Unsaturated	34-60	carboxylesterase 1C	Rattus norvegicus	83-92
28826373-6	2017	Specifically, although saturated fatty acids may promote NLRP3 inflammasome activation, monounsaturated fatty acids and polyunsaturated fatty acids have recently been shown to impede NLRP3 activity.	Fatty Acids, Unsaturated	120-147	NLR family pyrin domain containing 3	Homo sapiens	183-188
28835852-1	2017	BACKGROUND: Omega-3 long-chain (&gt;=C20) polyunsaturated fatty acids (omega3 LC-PUFA) confer important attributes to health-conscious meat consumers due to the significant role they play in brain development, prevention of coronary heart disease, obesity and hypertension.	Fatty Acids, Unsaturated	42-69	PUFA	Ovis aries	81-85
28450226-5	2017	Unsaturated fatty acids (oleic, elaidic, gamma-linolenic and docosahexaenoic acids) and acyl-CoAs (palmitoyl-, stearoyl- and oleoyl-CoAs) were more potent inhibitors (IC50 1.0-2.5microM), and showed high inhibitory selectivity to CBR1 over its isozyme CBR3 and other SDR superfamily enzymes (DCXR and DHRS4) with CBR activity.	Fatty Acids, Unsaturated	0-23	carbonyl reductase 1	Homo sapiens	230-234
28817082-1	2017	The objective of the study was to ascertain whether human health beneficial omega-3 long-chain (&gt;=C20) polyunsaturated fatty acid (n-3 LC-PUFA) content in heart, kidney and liver can be enhanced by supplementing prime lambs with graded levels of canola and flaxseed oil.	Fatty Acids, Unsaturated	106-132	pumilio RNA binding family member 3	Homo sapiens	141-145
28450226-5	2017	Unsaturated fatty acids (oleic, elaidic, gamma-linolenic and docosahexaenoic acids) and acyl-CoAs (palmitoyl-, stearoyl- and oleoyl-CoAs) were more potent inhibitors (IC50 1.0-2.5microM), and showed high inhibitory selectivity to CBR1 over its isozyme CBR3 and other SDR superfamily enzymes (DCXR and DHRS4) with CBR activity.	Fatty Acids, Unsaturated	0-23	carbonyl reductase 3	Homo sapiens	252-256
28450226-5	2017	Unsaturated fatty acids (oleic, elaidic, gamma-linolenic and docosahexaenoic acids) and acyl-CoAs (palmitoyl-, stearoyl- and oleoyl-CoAs) were more potent inhibitors (IC50 1.0-2.5microM), and showed high inhibitory selectivity to CBR1 over its isozyme CBR3 and other SDR superfamily enzymes (DCXR and DHRS4) with CBR activity.	Fatty Acids, Unsaturated	0-23	dicarbonyl and L-xylulose reductase	Homo sapiens	292-296
28450226-5	2017	Unsaturated fatty acids (oleic, elaidic, gamma-linolenic and docosahexaenoic acids) and acyl-CoAs (palmitoyl-, stearoyl- and oleoyl-CoAs) were more potent inhibitors (IC50 1.0-2.5microM), and showed high inhibitory selectivity to CBR1 over its isozyme CBR3 and other SDR superfamily enzymes (DCXR and DHRS4) with CBR activity.	Fatty Acids, Unsaturated	0-23	dehydrogenase/reductase 4	Homo sapiens	301-306
28601449-13	2017	In conclusion, the addition of chia seeds at the CHigh level in dairy goat diets negatively affected in vitro rumen fermentation, but increased the milk fatty acid profile of C18:0, C18:1n-9 cis, and C:20, monounsaturated fatty acids, and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	239-266	acidic mammalian chitinase	Capra hircus	31-35
28576465-5	2017	Met/CA treatment impaired expression of Sterol Regulatory Element-Binding Protein 1 (SREBP1c) which resulted in alleviation of de novo synthesis of unsaturated fatty acid.	Fatty Acids, Unsaturated	148-170	sterol regulatory element binding transcription factor 1	Homo sapiens	40-83
28576465-5	2017	Met/CA treatment impaired expression of Sterol Regulatory Element-Binding Protein 1 (SREBP1c) which resulted in alleviation of de novo synthesis of unsaturated fatty acid.	Fatty Acids, Unsaturated	148-170	sterol regulatory element binding transcription factor 1	Homo sapiens	85-92
28646265-1	2017	Polyunsaturated fatty acids have been reported to play a protective role in a wide range of diseases characterized by an increased metalloproteinases (MMPs) activity.	Fatty Acids, Unsaturated	0-27	matrix metallopeptidase 2	Homo sapiens	151-155
28838557-2	2017	FADS1 and FADS2 code for enzymes required for highly unsaturated fatty acid (HUFA) biosynthesis, but FADS3 function remains elusive.	Fatty Acids, Unsaturated	53-75	fatty acid desaturase 1	Mus musculus	0-5
28738820-0	2017	Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-kappaB pathway following experimental traumatic brain injury.	Fatty Acids, Unsaturated	8-34	high mobility group box 1	Rattus norvegicus	112-117
28838557-2	2017	FADS1 and FADS2 code for enzymes required for highly unsaturated fatty acid (HUFA) biosynthesis, but FADS3 function remains elusive.	Fatty Acids, Unsaturated	53-75	fatty acid desaturase 2	Mus musculus	10-15
28738820-0	2017	Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-kappaB pathway following experimental traumatic brain injury.	Fatty Acids, Unsaturated	8-34	toll-like receptor 4	Rattus norvegicus	118-122
28706274-2	2017	The DHA- or eicosapentaenoic acid (EPA)-derived 26 carbon fatty acid is a substrate of elongase ELOVL4, which is expressed in photoreceptor cells and generates very long chain (&gt;=C28) polyunsaturated fatty acids including n-3 (VLC-PUFAs,n-3).	Fatty Acids, Unsaturated	187-214	ELOVL fatty acid elongase 4	Homo sapiens	96-102
28237650-2	2017	CYP2J2 is a major cardiac CYP450 and primarily metabolizes polyunsaturated fatty acids such as arachidonic acid to cardioactive epoxyeicosatrienoic acids.	Fatty Acids, Unsaturated	59-86	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
28411230-9	2017	Deletion of 12/15-LOX in mice led to increased cytochrome P-450-derived bioactive lipid mediator epoxyeicosatrienoic acids (EETs), i.e., 11,12-EpETrE and 14,15-EpETrE, which were further enhanced by acute PUFA intake post-MI.	Fatty Acids, Unsaturated	205-209	arachidonate 15-lipoxygenase	Mus musculus	18-21
28225172-8	2017	It indicated that miR-144 could regulate some saturated fatty acids elongated to longer unsaturated fatty acids through controlling ELOVL6 expression.	Fatty Acids, Unsaturated	88-111	microRNA 144	Homo sapiens	18-25
28570057-5	2017	Results showed significantly lower concentrations of both milk polyunsaturated fatty acid content and total oxylipid biosynthesis during early lactation when compared to mid- or late-lactation.	Fatty Acids, Unsaturated	63-89	Weaning weight-maternal milk	Bos taurus	58-62
28587203-9	2017	CONCLUSIONS: We found a beneficial effect of n-3 PUFA supplementation on waist circumference, glucose, Hb1Ac, leptin, leptin/adiponectin ratio, and lipid profile, without significant changes in adiponectin, and increases in resistin, insulin, and HOMA-IR in both groups.	Fatty Acids, Unsaturated	49-53	leptin	Homo sapiens	110-116
28587203-9	2017	CONCLUSIONS: We found a beneficial effect of n-3 PUFA supplementation on waist circumference, glucose, Hb1Ac, leptin, leptin/adiponectin ratio, and lipid profile, without significant changes in adiponectin, and increases in resistin, insulin, and HOMA-IR in both groups.	Fatty Acids, Unsaturated	49-53	leptin	Homo sapiens	118-124
28587203-9	2017	CONCLUSIONS: We found a beneficial effect of n-3 PUFA supplementation on waist circumference, glucose, Hb1Ac, leptin, leptin/adiponectin ratio, and lipid profile, without significant changes in adiponectin, and increases in resistin, insulin, and HOMA-IR in both groups.	Fatty Acids, Unsaturated	49-53	adiponectin, C1Q and collagen domain containing	Homo sapiens	125-136
28400162-3	2017	Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	231-258	arachidonate 15-lipoxygenase	Homo sapiens	22-28
28400162-3	2017	Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	231-258	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	93-99
28400162-3	2017	Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	231-258	arachidonate 15-lipoxygenase type B	Homo sapiens	104-111
28400162-3	2017	Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	260-265	arachidonate 15-lipoxygenase	Homo sapiens	22-28
28400162-3	2017	Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	260-265	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	93-99
28235613-0	2017	Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD.	Fatty Acids, Unsaturated	38-65	transmembrane 6 superfamily member 2	Homo sapiens	69-75
28235613-11	2017	Incorporation of PUFA into TGs and PCs in TM6SF2 knockdown hepatocytes was decreased (p&lt;0.05).	Fatty Acids, Unsaturated	17-21	transmembrane 6 superfamily member 2	Homo sapiens	42-48
28665359-3	2017	In this study, we detected that ELOVL5, which plays a key role in the biosynthesis of omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA), was highly expressed in the liver of laying hens and increased rapidly after sexual maturity.	Fatty Acids, Unsaturated	147-151	ELOVL fatty acid elongase 5	Gallus gallus	32-38
28225172-8	2017	It indicated that miR-144 could regulate some saturated fatty acids elongated to longer unsaturated fatty acids through controlling ELOVL6 expression.	Fatty Acids, Unsaturated	88-111	ELOVL fatty acid elongase 6	Homo sapiens	132-138
27448180-8	2017	Overexpression of miR-145 increased transcription of genes associated with milk fat synthesis resulting in greater fat droplet formation, triacylglycerol accumulation, and proportion of unsaturated fatty acids.	Fatty Acids, Unsaturated	186-209	microRNA 145	Capra hircus	18-25
28611031-3	2017	METHODS AND RESULTS: Using array-based and targeted genotyping, we found that rs80356779, a p.Pro479Leu variant in CPT1A, was strongly associated with markers of n-3 fatty acid metabolism, including degree of unsaturation (P=1.16x10-34), levels of polyunsaturated fatty acids, n-3 fatty acids, and docosahexaoenic acid relative to total fatty acid levels (P=2.35x10-15, P=4.02x10-19, and P=7.92x10-27).	Fatty Acids, Unsaturated	248-275	carnitine palmitoyltransferase 1A	Homo sapiens	115-120
28555039-2	2017	Fatty acid desaturase (FADS) single nucleotide polymorphisms (SNPs) modulate circulating PUFA concentrations.	Fatty Acids, Unsaturated	89-93	stearoyl-CoA desaturase	Homo sapiens	0-21
28555039-2	2017	Fatty acid desaturase (FADS) single nucleotide polymorphisms (SNPs) modulate circulating PUFA concentrations.	Fatty Acids, Unsaturated	89-93	stearoyl-CoA desaturase	Homo sapiens	23-27
28388313-5	2017	We have earlier reported that the N-6 and N-3 poly-unsaturated fatty acids (PUFAs), Arachidonic acid (AA)/Docosahexanoic acid (DHA) have beneficial effect on the generation of MKs and PLTs from umbilical cord blood derived CD34+ cells.	Fatty Acids, Unsaturated	76-81	CD34 molecule	Homo sapiens	223-227
31740640-5	2017	P2X7 receptor antagonists, such as divalent cations and Brilliant Blue G (BBG) could be used to target either the ocular surface or the retina, as long as polyunsaturated fatty acids may exert their effects through the disruption of plasma membrane lipid rafts or saffron that reduces the response evoked by P2X7 receptor stimulation.	Fatty Acids, Unsaturated	155-182	purinergic receptor P2X 7	Homo sapiens	0-13
28503188-1	2017	BACKGROUND: No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A2 (Lp-PLA2), which is a risk factor for cardiovascular disease (CVD).	Fatty Acids, Unsaturated	121-126	phospholipase A2 group VII	Homo sapiens	132-171
28503189-1	2017	BACKGROUND: Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrophages.	Fatty Acids, Unsaturated	122-145	free fatty acid receptor 4	Mus musculus	172-202
28503189-1	2017	BACKGROUND: Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrophages.	Fatty Acids, Unsaturated	122-145	free fatty acid receptor 4	Mus musculus	204-210
27768859-5	2017	We have found that 4-hydroxyalkenals, non-enzymatic peroxidation products of polyunsaturated fatty acids (PUFA), namely, 4-hydroxy-2E,6Z-dodecadienal (4-HDDE) and 4-hydroxy-2E-nonenal (4-HNE), activate PPARdelta in vascular endothelial cells and insulin-secreting beta cells, respectively.	Fatty Acids, Unsaturated	77-104	peroxisome proliferator activated receptor delta	Homo sapiens	202-211
27768859-5	2017	We have found that 4-hydroxyalkenals, non-enzymatic peroxidation products of polyunsaturated fatty acids (PUFA), namely, 4-hydroxy-2E,6Z-dodecadienal (4-HDDE) and 4-hydroxy-2E-nonenal (4-HNE), activate PPARdelta in vascular endothelial cells and insulin-secreting beta cells, respectively.	Fatty Acids, Unsaturated	106-110	peroxisome proliferator activated receptor delta	Homo sapiens	202-211
28520810-11	2017	Further, unsaturated fatty acids confer lipoprotection, enhancing viability and function of GLP-1-secreting cells.	Fatty Acids, Unsaturated	9-32	glucagon	Mus musculus	92-97
27190274-0	2017	Polyunsaturated fatty acid induces cardioprotection against ischemia-reperfusion through the inhibition of NF-kappaB and induction of Nrf2.	Fatty Acids, Unsaturated	0-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
27190274-8	2017	Hearts in the group supplemented with PUFA showed lower levels of oxidative stress markers and higher antioxidant activity, decreased MPO activity and NF-kappaB and Nrf2 activation compared with the nonsupplemented group.	Fatty Acids, Unsaturated	38-42	myeloperoxidase	Rattus norvegicus	134-137
27190274-8	2017	Hearts in the group supplemented with PUFA showed lower levels of oxidative stress markers and higher antioxidant activity, decreased MPO activity and NF-kappaB and Nrf2 activation compared with the nonsupplemented group.	Fatty Acids, Unsaturated	38-42	NFE2 like bZIP transcription factor 2	Rattus norvegicus	165-169
28294699-7	2017	CHIA, despite high polyunsaturated fatty acids (PUFA) content, reduced thiobarbituric acid reactive substances (TBARS) and induced the lowest SOD protein synthesis but not a reduction on its activity.	Fatty Acids, Unsaturated	19-46	chitinase, acidic	Rattus norvegicus	0-4
28524009-9	2017	The OXTR CC genotype was found significantly associated with higher contents of odd branched-chain fatty acids (OBCFA) (P &lt; 0 0006), polyunsaturated FA (PUFA n 3 and n 6) (P &lt; 0 0032 and P &lt; 0 0006, respectively), stearic acid (C18) (P &lt; 0 02) and lower level of palmitic acid (C16) (P &lt; 0 02).	Fatty Acids, Unsaturated	156-160	oxytocin receptor	Bubalus bubalis	4-8
28294699-7	2017	CHIA, despite high polyunsaturated fatty acids (PUFA) content, reduced thiobarbituric acid reactive substances (TBARS) and induced the lowest SOD protein synthesis but not a reduction on its activity.	Fatty Acids, Unsaturated	48-52	chitinase, acidic	Rattus norvegicus	0-4
28359359-8	2017	The increase of 1 g/1000 kcal in PUFAs, omega-3, and omega-6 reduces, on average, 6%, 48%, and 8% respectively, the mean concentration of IL-1 beta.	Fatty Acids, Unsaturated	33-38	interleukin 1 beta	Homo sapiens	138-147
27838193-9	2017	RESULTS: Plasma marine n-3 PUFA levels were inversely associated with plasma levels of proinflammatory biomarkers soluble tumor necrosis factor receptor 1 (standardized regression coefficient -0.11, P &lt; .001) and interleukin-6 (standardized regression coefficient -0.09, P = .01).	Fatty Acids, Unsaturated	27-31	interleukin 6	Homo sapiens	216-229
28351093-6	2017	Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=-0.53, p=0.004).	Fatty Acids, Unsaturated	187-214	angiopoietin like 8	Homo sapiens	12-19
28579896-3	2017	In humans, stearoyl-CoA desaturase 1 (SCD-1) is a restriction step to saturation to unsaturated fatty acid desaturation, which plays a beneficial role protecting endothelial cells against lipotoxicity.	Fatty Acids, Unsaturated	84-106	stearoyl-CoA desaturase	Homo sapiens	11-36
28515017-2	2017	FABP3 was shown to be involved in long chain polyunsaturated fatty acids (LCPUFA) uptake in human trophoblastic choriocarcinoma cells, BeWo as the uptake of arachidonic acid,20:4n-6 (ARA) was decreased in FABP3-knockdown BeWo cells.	Fatty Acids, Unsaturated	45-72	fatty acid binding protein 3	Homo sapiens	0-5
28579896-3	2017	In humans, stearoyl-CoA desaturase 1 (SCD-1) is a restriction step to saturation to unsaturated fatty acid desaturation, which plays a beneficial role protecting endothelial cells against lipotoxicity.	Fatty Acids, Unsaturated	84-106	stearoyl-CoA desaturase	Homo sapiens	38-43
28232489-0	2017	alpha-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection.	Fatty Acids, Unsaturated	52-78	synuclein alpha	Homo sapiens	0-15
28422962-8	2017	METHODS: Ldlr -/- mice fed the WD for 22 wks developed metabolic syndrome (MetS) and a severe NASH phenotype, including obesity, dyslipidemia, hyperglycemia, hepatic steatosis, inflammation, fibrosis and low hepatic polyunsaturated fatty acid (PUFA) content.	Fatty Acids, Unsaturated	216-242	low density lipoprotein receptor	Mus musculus	9-13
28258215-7	2017	By using quantitative co-immunoprecipitation assays coupled with tandem mass spectrometry, we identified potential binding partners of ABCD2 involved in polyunsaturated fatty-acid metabolism.	Fatty Acids, Unsaturated	153-179	ATP binding cassette subfamily D member 2	Homo sapiens	135-140
28422962-8	2017	METHODS: Ldlr -/- mice fed the WD for 22 wks developed metabolic syndrome (MetS) and a severe NASH phenotype, including obesity, dyslipidemia, hyperglycemia, hepatic steatosis, inflammation, fibrosis and low hepatic polyunsaturated fatty acid (PUFA) content.	Fatty Acids, Unsaturated	244-248	low density lipoprotein receptor	Mus musculus	9-13
27480217-1	2017	12/15-Lipoxygenase (12/15-LOX) mediates the enzymatic oxidation of polyunsaturated fatty acids, thereby contributing to the generation of various bioactive lipid mediators.	Fatty Acids, Unsaturated	67-94	arachidonate 15-lipoxygenase	Homo sapiens	0-18
28275132-2	2017	Diets that are high in saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs) have different metabolic responses.Objective: We investigated whether the epigenome of human adipose tissue is affected differently by dietary fat composition and general overfeeding in a randomized trial.Design: We studied the effects of 7 wk of excessive SFA (n = 17) or PUFA (n = 14) intake (+750 kcal/d) on the DNA methylation of ~450,000 sites in human subcutaneous adipose tissue.	Fatty Acids, Unsaturated	55-82	pumilio RNA binding family member 3	Homo sapiens	84-88
27480217-1	2017	12/15-Lipoxygenase (12/15-LOX) mediates the enzymatic oxidation of polyunsaturated fatty acids, thereby contributing to the generation of various bioactive lipid mediators.	Fatty Acids, Unsaturated	67-94	arachidonate 15-lipoxygenase	Homo sapiens	20-29
28202541-6	2017	Previously, we showed that Sre1 cleavage is defective in the absence of mga2 Here, we report that this defect is due to deficient unsaturated fatty acid synthesis, resulting in aberrant membrane transport.	Fatty Acids, Unsaturated	130-152	Mga2p	Saccharomyces cerevisiae S288C	72-76
28334272-2	2017	ACSL4 prefers 20-carbon polyunsaturated fatty acid (PUFA) substrates, and along with other ACSLs has been associated with cellular uptake of exogenous fatty acids.	Fatty Acids, Unsaturated	52-56	acyl-CoA synthetase long chain family member 4	Homo sapiens	0-5
28334272-4	2017	In this study, treatment of steroid-starved ERalpha-positive MCF-7 and T47D mammary carcinoma cells with 17beta-estradiol resulted in increased cellular uptake of the PUFA arachidonic acid (AA) and eicosapentaenoic acid (EPA), important building blocks for cellular membranes, and increased ACSL4 protein levels.	Fatty Acids, Unsaturated	167-171	estrogen receptor 1	Homo sapiens	44-51
28334272-4	2017	In this study, treatment of steroid-starved ERalpha-positive MCF-7 and T47D mammary carcinoma cells with 17beta-estradiol resulted in increased cellular uptake of the PUFA arachidonic acid (AA) and eicosapentaenoic acid (EPA), important building blocks for cellular membranes, and increased ACSL4 protein levels.	Fatty Acids, Unsaturated	167-171	acyl-CoA synthetase long chain family member 4	Homo sapiens	291-296
26926575-8	2017	Habitual polyunsaturated fatty acid (PUFA) consumption was negatively associated with basal GPR119 expression.	Fatty Acids, Unsaturated	9-35	G protein-coupled receptor 119	Homo sapiens	92-98
26926575-8	2017	Habitual polyunsaturated fatty acid (PUFA) consumption was negatively associated with basal GPR119 expression.	Fatty Acids, Unsaturated	37-41	G protein-coupled receptor 119	Homo sapiens	92-98
27665576-5	2017	The LPL-induced hepatic PPARalpha activation was weakened by blocking the LPL enzymatic activity, and by preventing the cellular uptake of free unsaturated fatty acids with either albumin chelator or silencing of CD36 translocase.	Fatty Acids, Unsaturated	144-167	lipoprotein lipase	Mus musculus	4-7
27665576-5	2017	The LPL-induced hepatic PPARalpha activation was weakened by blocking the LPL enzymatic activity, and by preventing the cellular uptake of free unsaturated fatty acids with either albumin chelator or silencing of CD36 translocase.	Fatty Acids, Unsaturated	144-167	peroxisome proliferator activated receptor alpha	Mus musculus	24-33
28179134-3	2017	The results demonstrate that most of the unsaturated fatty acids showed marked inhibition towards CYP2C8 mediated amodiaquine N-deethylation followed by inhibition of CYP2C9 and CYP2B6 mediated activities.	Fatty Acids, Unsaturated	41-64	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	98-104
28179134-3	2017	The results demonstrate that most of the unsaturated fatty acids showed marked inhibition towards CYP2C8 mediated amodiaquine N-deethylation followed by inhibition of CYP2C9 and CYP2B6 mediated activities.	Fatty Acids, Unsaturated	41-64	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	167-173
28179134-3	2017	The results demonstrate that most of the unsaturated fatty acids showed marked inhibition towards CYP2C8 mediated amodiaquine N-deethylation followed by inhibition of CYP2C9 and CYP2B6 mediated activities.	Fatty Acids, Unsaturated	41-64	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	178-184
28386235-5	2017	Results: Rats refed the PUFA diet gained less lipids and more proteins compared to rats refed SFA-MUFA diet and showed lower amount of visceral and epididymal white adipose tissue, but increased depots of interscapular brown adipose tissue, with higher expression of the uncoupling protein 1.	Fatty Acids, Unsaturated	24-28	uncoupling protein 1	Rattus norvegicus	271-291
28087695-9	2017	Furthermore, triacylglycerols from HepG2-SMS1 cells are enriched in polyunsaturated fatty acids, which is indicative of active remodeling.	Fatty Acids, Unsaturated	68-95	sphingomyelin synthase 1	Homo sapiens	35-45
28356106-10	2017	These effects of n-3 polyunsaturated fatty acids (PUFA) on lipid metabolism may be linked to the upregulation of Fra1 and attenuated activity of c-Jun and c-Fos, thus ultimately reducing the severity of the lipid metabolism disorder and liver damage to some extent.	Fatty Acids, Unsaturated	50-54	fos-like antigen 1	Mus musculus	113-117
28356106-10	2017	These effects of n-3 polyunsaturated fatty acids (PUFA) on lipid metabolism may be linked to the upregulation of Fra1 and attenuated activity of c-Jun and c-Fos, thus ultimately reducing the severity of the lipid metabolism disorder and liver damage to some extent.	Fatty Acids, Unsaturated	50-54	jun proto-oncogene	Mus musculus	145-150
28356106-10	2017	These effects of n-3 polyunsaturated fatty acids (PUFA) on lipid metabolism may be linked to the upregulation of Fra1 and attenuated activity of c-Jun and c-Fos, thus ultimately reducing the severity of the lipid metabolism disorder and liver damage to some extent.	Fatty Acids, Unsaturated	50-54	FBJ osteosarcoma oncogene	Mus musculus	155-160
28119456-8	2017	An extensive lipidomic screen of choline derivatives showed that total phosphatidylcholine and phosphatidylinositol (but not diacylglycerol or sphingomyelin) are significantly elevated in NECL4-deficient Schwann cells, particularly specific subspecies of phosphatidylcholine carrying very long polyunsaturated fatty acid chains.	Fatty Acids, Unsaturated	294-320	cell adhesion molecule 4	Homo sapiens	188-193
28252054-4	2017	Using qRT-PCR and Western blot analysis, we demonstrated that PEPCK-C was functionally expressed and had a significant effect on total fatty acid content in the skeletal muscle of the transgenic pigs, while the n-6/n-3 polyunsaturated fatty acid (PUFA) ratio showed no difference between transgenic and control pigs.	Fatty Acids, Unsaturated	219-245	phosphoenolpyruvate carboxykinase 2, mitochondrial	Sus scrofa	62-67
28193492-9	2017	ACSL4 and ACSL3 knockdown cells showed inhibition of ACSL enzyme activity more with arachidonate than with palmitate as a substrate, consistent with their preference for unsaturated fatty acids as substrates.	Fatty Acids, Unsaturated	170-193	acyl-CoA synthetase long-chain family member 4	Rattus norvegicus	0-5
28193492-9	2017	ACSL4 and ACSL3 knockdown cells showed inhibition of ACSL enzyme activity more with arachidonate than with palmitate as a substrate, consistent with their preference for unsaturated fatty acids as substrates.	Fatty Acids, Unsaturated	170-193	acyl-CoA synthetase long-chain family member 3	Rattus norvegicus	10-15
28272345-1	2017	BACKGROUND: The transport of polyunsaturated fatty acids (PUFAs), such as arachidonic acid (ARA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), to the fetus from maternal stores increases depending on the fetal requirements for PUFA during the last trimester of pregnancy.	Fatty Acids, Unsaturated	29-56	pumilio RNA binding family member 3	Homo sapiens	58-62
28267800-1	2017	This study investigated whether intake of cow milk, naturally enriched with polyunsaturated fatty acids (PUFA, omega-3) and polyphenols (from propolis extract and vitamin E), from manipulation of cow"s diet, would result in positive metabolic effects in rats from weaning until adulthood.	Fatty Acids, Unsaturated	76-103	PUFA	Bos taurus	105-109
27913949-1	2017	Astaxanthin (AST), a red dietary carotenoid, has synergistic antioxidant effects with polyunsaturated fatty acids at low concentrations via Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or Nrf2)/antioxidant response element (ARE) signaling.	Fatty Acids, Unsaturated	86-113	NFE2 like bZIP transcription factor 2	Homo sapiens	140-183
27913949-1	2017	Astaxanthin (AST), a red dietary carotenoid, has synergistic antioxidant effects with polyunsaturated fatty acids at low concentrations via Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or Nrf2)/antioxidant response element (ARE) signaling.	Fatty Acids, Unsaturated	86-113	NFE2 like bZIP transcription factor 2	Homo sapiens	185-191
28252054-4	2017	Using qRT-PCR and Western blot analysis, we demonstrated that PEPCK-C was functionally expressed and had a significant effect on total fatty acid content in the skeletal muscle of the transgenic pigs, while the n-6/n-3 polyunsaturated fatty acid (PUFA) ratio showed no difference between transgenic and control pigs.	Fatty Acids, Unsaturated	247-251	phosphoenolpyruvate carboxykinase 2, mitochondrial	Sus scrofa	62-67
27596631-1	2017	OLE1 of Saccharomyces cerevisiae encodes the sole and essential Delta-9 desaturase catalyzing the conversion of saturated to unsaturated fatty acids.	Fatty Acids, Unsaturated	125-148	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
30615382-7	2017	To synthesize endogenous oleic mono unsaturated fatty acid the late in phylogenesis insulin expresses two enzymes of coupled biochemical reactions: palmitoyl-KoA-elongase andstearyl-KoA-desaturase, activating synthesis of fatty acids following the path glucose-endogenous palmitic unsaturated fatty acid-stearic unsaturated fatty acid-oleic mono unsaturated fatty acid.	Fatty Acids, Unsaturated	281-304	insulin	Homo sapiens	84-91
28039586-4	2017	In both SP and NSP, lower n-6 polyunsaturated FA (PUFA) accompanied by higher proportions of monounsaturated FA (MUFA) in plasma phospholipids (PPL) was observed relative to HC.	Fatty Acids, Unsaturated	50-54	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	15-18
28507800-1	2017	Chronic inflammation can result from inadequate engagement of resolution mechanisms, mainly accomplished by specialized pro-resolving mediators (SPMs) arising from the metabolic activity of lipoxygenases (ALOX5/15) on omega-6 or omega-3 essential polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	276-280	arachidonate 5-lipoxygenase	Mus musculus	205-236
28086243-6	2017	Thin-layer chromatography and MALDI-MS/MS reveals that FASN-inhibitors (C75, G28UCM) augment polyunsaturated fatty acids and diminish signaling lipids diacylglycerol (DAG) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) in OC cells (SKOV3, OVCAR-3, A2780, HOC-7).	Fatty Acids, Unsaturated	93-120	fatty acid synthase	Homo sapiens	55-59
27787227-6	2017	OLE1 encodes for the essential Delta9-fatty acid desaturase Ole1 and is crucial for de novo biosynthesis of unsaturated fatty acids (UFAs) that are used as lipid building blocks.	Fatty Acids, Unsaturated	108-131	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
27787227-6	2017	OLE1 encodes for the essential Delta9-fatty acid desaturase Ole1 and is crucial for de novo biosynthesis of unsaturated fatty acids (UFAs) that are used as lipid building blocks.	Fatty Acids, Unsaturated	108-131	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	60-64
27787227-6	2017	OLE1 encodes for the essential Delta9-fatty acid desaturase Ole1 and is crucial for de novo biosynthesis of unsaturated fatty acids (UFAs) that are used as lipid building blocks.	Fatty Acids, Unsaturated	133-137	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
27787227-6	2017	OLE1 encodes for the essential Delta9-fatty acid desaturase Ole1 and is crucial for de novo biosynthesis of unsaturated fatty acids (UFAs) that are used as lipid building blocks.	Fatty Acids, Unsaturated	133-137	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	60-64
26005184-4	2017	GPR40, when binding with polyunsaturated fatty acids (PUFAs) has shown promising therapeutic potential.	Fatty Acids, Unsaturated	25-52	free fatty acid receptor 1	Homo sapiens	0-5
26005184-4	2017	GPR40, when binding with polyunsaturated fatty acids (PUFAs) has shown promising therapeutic potential.	Fatty Acids, Unsaturated	54-59	free fatty acid receptor 1	Homo sapiens	0-5
28218036-2	2017	Omega-3 polyunsaturated fatty acids and atorvastatin proved anti-inflammatory effects through peroxisome proliferator-activated receptor gamma mechanism.	Fatty Acids, Unsaturated	8-35	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	94-142
28012856-7	2017	Further, in HCC patients, FNDC5/Irisin mRNA tended to correlate to plasma lipid profile namely triglycerides, palmitic/linoleic acid and polyunsaturated fatty acid/saturated fatty acid ratios.	Fatty Acids, Unsaturated	137-163	fibronectin type III domain containing 5	Homo sapiens	26-31
28012856-7	2017	Further, in HCC patients, FNDC5/Irisin mRNA tended to correlate to plasma lipid profile namely triglycerides, palmitic/linoleic acid and polyunsaturated fatty acid/saturated fatty acid ratios.	Fatty Acids, Unsaturated	137-163	fibronectin type III domain containing 5	Homo sapiens	32-38
27913621-2	2017	Hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in triglycerides transport and endoplasmic reticulum stress response due to its unique ability to catalyze the incorporation of polyunsaturated fatty acids into phospholipids.	Fatty Acids, Unsaturated	210-237	lysophosphatidylcholine acyltransferase 3	Mus musculus	8-49
28109294-0	2017	Probing the intermolecular interactions of PPARgamma-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties.	Fatty Acids, Unsaturated	62-89	peroxisome proliferator activated receptor gamma	Homo sapiens	43-52
28109294-5	2017	Polyunsaturated fatty acids (PUFAs) and their metabolites (henceforth referred to as bioactive lipids) are known to function as agonists of PPARgamma.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor gamma	Homo sapiens	140-149
28109294-5	2017	Polyunsaturated fatty acids (PUFAs) and their metabolites (henceforth referred to as bioactive lipids) are known to function as agonists of PPARgamma.	Fatty Acids, Unsaturated	29-34	peroxisome proliferator activated receptor gamma	Homo sapiens	140-149
27913621-2	2017	Hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in triglycerides transport and endoplasmic reticulum stress response due to its unique ability to catalyze the incorporation of polyunsaturated fatty acids into phospholipids.	Fatty Acids, Unsaturated	210-237	lysophosphatidylcholine acyltransferase 3	Mus musculus	51-57
27062905-5	2017	MAJOR CONCLUSIONS: Excessive nSMase activation by polyunsaturated fatty acids (PUFA), such as arachidonic acid (ARA) leads to disruption of the SM molecules and associated hydrogen bond network, with subsequent access of host antibodies and immune effectors to the outer membrane and eventual parasite death.	Fatty Acids, Unsaturated	50-77	sphingomyelin phosphodiesterase 2	Homo sapiens	29-35
27198984-0	2017	Effect of PUFAs Oral Administration on the Amount of Apoptotic Caspases Enzymes in Gastric Cancer Patients Undergoing Chemotherapy.	Fatty Acids, Unsaturated	10-15	caspase 8	Homo sapiens	63-71
27198984-12	2017	RESULTS: In the case group, caspase 3 showed a significant increase in both gene and protein expression levels after administration of PUFAs supplement in comparison with those of the control group (p=0.006 for gene, p=0.001 for protein).	Fatty Acids, Unsaturated	135-140	caspase 3	Homo sapiens	28-37
27062905-5	2017	MAJOR CONCLUSIONS: Excessive nSMase activation by polyunsaturated fatty acids (PUFA), such as arachidonic acid (ARA) leads to disruption of the SM molecules and associated hydrogen bond network, with subsequent access of host antibodies and immune effectors to the outer membrane and eventual parasite death.	Fatty Acids, Unsaturated	79-83	sphingomyelin phosphodiesterase 2	Homo sapiens	29-35
28769007-1	2017	The free fatty acid receptor 1 (GPR40/FFAR1) is activated by polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acids (DHA).	Fatty Acids, Unsaturated	61-88	free fatty acid receptor 1	Mus musculus	32-37
28245901-0	2017	Genetic Variants in the ELOVL5 but not ELOVL2 Gene Associated with Polyunsaturated Fatty Acids in Han Chinese Breast Milk.	Fatty Acids, Unsaturated	67-94	ELOVL fatty acid elongase 5	Homo sapiens	24-30
28769007-1	2017	The free fatty acid receptor 1 (GPR40/FFAR1) is activated by polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acids (DHA).	Fatty Acids, Unsaturated	61-88	free fatty acid receptor 1	Mus musculus	38-43
28769007-1	2017	The free fatty acid receptor 1 (GPR40/FFAR1) is activated by polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acids (DHA).	Fatty Acids, Unsaturated	90-95	free fatty acid receptor 1	Mus musculus	32-37
28769007-1	2017	The free fatty acid receptor 1 (GPR40/FFAR1) is activated by polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acids (DHA).	Fatty Acids, Unsaturated	90-95	free fatty acid receptor 1	Mus musculus	38-43
27475923-2	2017	However, production of isoamyl acetate by Saccharomyces cerevisiae is significantly reduced during sake brewing with rice that has a high polishing ratio, because unsaturated fatty acids derived from the outer layer of rice repress the expression of ATF1, which encodes an alcohol acetyl transferase.	Fatty Acids, Unsaturated	163-186	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	250-254
28034286-4	2017	METHOD: We examined the effects of glucose, saturated fatty acids, and unsaturated fatty acids on PRCP expression in cultured H9c2 cells as an in-vitro model for pharmacological studies.	Fatty Acids, Unsaturated	71-94	prolylcarboxypeptidase	Rattus norvegicus	98-102
29083445-7	2017	The analysis of the same polymorphisms showed association at the P value &lt;0.05 with nutrients (fat, SFA, and polyunsaturated fatty acid - PUFA and saccharose) and elevated LDL level.	Fatty Acids, Unsaturated	112-138	pumilio RNA binding family member 3	Homo sapiens	141-145
27484441-1	2017	BACKGROUND: Several studies have shown that omega-3 polyunsaturated fatty acids (PUFA) may improve insulin resistance in various diseases.	Fatty Acids, Unsaturated	81-85	insulin	Homo sapiens	99-106
27789520-3	2017	Here, we show that n-3 polyunsaturated fatty acids (PUFAs), by use of fat-1 transgenic mice and oral administration of fish oil, significantly promote interstitial Abeta clearance from the brain and resist Abeta injury.	Fatty Acids, Unsaturated	52-57	FAT atypical cadherin 1	Mus musculus	70-75
27475923-7	2017	ATF1 was expressed constitutively in the hia1 mutant during brewing and remained derepressed upon the addition of unsaturated fatty acids.	Fatty Acids, Unsaturated	114-137	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	0-4
27475923-10	2017	The expression of ATF1 was elevated in BY4743 Deltamga2 cells complemented with MGA2 (Ser706*), and this was not completely inhibited by the addition of unsaturated fatty acids.	Fatty Acids, Unsaturated	153-176	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	18-22
27980502-7	2017	The major changes of the metabolite profiles following G-CSF administration included alteration of several fatty acids, including increased levels of several medium and long-chain fatty acids, as well as polyunsaturated fatty acids; while there were lower levels of other lipid metabolites such as phospholipids, lysolipids, sphingolipids.	Fatty Acids, Unsaturated	204-231	colony stimulating factor 3	Homo sapiens	55-60
29017158-1	2017	OBJECTIVE: To determine the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on circulatory resistin and monocyte chemoattractant protein 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients.	Fatty Acids, Unsaturated	92-97	C-C motif chemokine ligand 2	Homo sapiens	127-161
29017158-1	2017	OBJECTIVE: To determine the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on circulatory resistin and monocyte chemoattractant protein 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients.	Fatty Acids, Unsaturated	92-97	C-C motif chemokine ligand 2	Homo sapiens	163-168
27992998-0	2016	Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase.	Fatty Acids, Unsaturated	37-64	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	76-82
27919543-1	2017	BACKGROUND AND AIMS: Maternal polyunsaturated fatty acid (PUFA) levels are associated with cord blood lipid and insulin levels.	Fatty Acids, Unsaturated	30-56	insulin	Homo sapiens	112-119
27919543-1	2017	BACKGROUND AND AIMS: Maternal polyunsaturated fatty acid (PUFA) levels are associated with cord blood lipid and insulin levels.	Fatty Acids, Unsaturated	58-62	insulin	Homo sapiens	112-119
27919543-10	2017	CONCLUSIONS: Higher maternal total n-3 PUFAs and specifically DHA levels during pregnancy are associated with higher childhood total-cholesterol, HDL-cholesterol and insulin levels.	Fatty Acids, Unsaturated	39-44	insulin	Homo sapiens	166-173
27891824-6	2017	Among the three major polyunsaturated fatty acid metabolizing pathways (cyclooxygenase, lipoxygenase, and CYP), CYP-derived fatty acid epoxides were the most dramatically altered LMs.	Fatty Acids, Unsaturated	22-48	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	106-109
27891824-6	2017	Among the three major polyunsaturated fatty acid metabolizing pathways (cyclooxygenase, lipoxygenase, and CYP), CYP-derived fatty acid epoxides were the most dramatically altered LMs.	Fatty Acids, Unsaturated	22-48	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	112-115
28018975-4	2016	These orally bioavailable compounds consist of a polyunsaturated fatty acid conjugated to salicylic acid and potently suppress the pathogenic NF-kappaB subunit p65/RelA in vitro.	Fatty Acids, Unsaturated	49-75	nuclear factor kappa B subunit 1	Homo sapiens	142-151
28018975-4	2016	These orally bioavailable compounds consist of a polyunsaturated fatty acid conjugated to salicylic acid and potently suppress the pathogenic NF-kappaB subunit p65/RelA in vitro.	Fatty Acids, Unsaturated	49-75	RELA proto-oncogene, NF-kB subunit	Canis lupus familiaris	164-168
27992998-0	2016	Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase.	Fatty Acids, Unsaturated	66-71	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	76-82
27992998-1	2016	Cytochrome P450 (CYP) 2J2 is the primary epoxygenase in the heart and is responsible for the epoxidation of arachidonic acid (AA), an omega-6 polyunsaturated fatty acid (PUFA), into anti-inflammatory epoxide metabolites.	Fatty Acids, Unsaturated	170-174	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-25
27663184-2	2016	Dietary fat, especially polyunsaturated fatty acids (PUFA), regulate pancreatic lipase (PNLIP); however, the molecular mechanism underlying this regulation is mostly unknown.	Fatty Acids, Unsaturated	24-51	pancreatic lipase	Rattus norvegicus	69-86
27793829-7	2017	The addition of exogenous unsaturated fatty acids simulated overexpression of OLE1, leading to cadmium resistance.	Fatty Acids, Unsaturated	26-49	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	78-82
27793829-8	2017	Such regulation of OLE1 in the synthesis of unsaturated fatty acids may serve as a positive feedback mechanism to help cells counter the lipid peroxidation and cytoplasmic membrane damage caused by cadmium.	Fatty Acids, Unsaturated	44-67	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	19-23
27793829-10	2017	The data suggest that the regulation of OLE1 in the synthesis of unsaturated fatty acids may serve as a positive feedback mechanism to help yeast cells counter the lipid peroxidation and cytoplasmic membrane damage caused by cadmium.	Fatty Acids, Unsaturated	65-88	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	40-44
27663184-2	2016	Dietary fat, especially polyunsaturated fatty acids (PUFA), regulate pancreatic lipase (PNLIP); however, the molecular mechanism underlying this regulation is mostly unknown.	Fatty Acids, Unsaturated	24-51	pancreatic lipase	Rattus norvegicus	88-93
27663184-2	2016	Dietary fat, especially polyunsaturated fatty acids (PUFA), regulate pancreatic lipase (PNLIP); however, the molecular mechanism underlying this regulation is mostly unknown.	Fatty Acids, Unsaturated	53-57	pancreatic lipase	Rattus norvegicus	69-86
27663184-2	2016	Dietary fat, especially polyunsaturated fatty acids (PUFA), regulate pancreatic lipase (PNLIP); however, the molecular mechanism underlying this regulation is mostly unknown.	Fatty Acids, Unsaturated	53-57	pancreatic lipase	Rattus norvegicus	88-93
27796616-1	2016	Accurate assessment of the long chain polyunsaturated fatty acid (LC-PUFA) content of human milk (HM) provides a powerful means to evaluate the FA nutrient status of breastfed infants.	Fatty Acids, Unsaturated	38-64	pumilio RNA binding family member 3	Homo sapiens	69-73
27588389-1	2016	BACKGROUND: The goal of present investigation is to check the hypothesis that cardioprotective effect of polyunsaturated fatty acids (PUFAs) is mediated by influence on mRNA expression level of the FATP, IL-1ra and GJP43 through stimulation of PPARgamma.	Fatty Acids, Unsaturated	105-132	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	244-253
27452044-2	2016	Since the anti-inflammatory properties of A1AT are influenced by the presence of polyunsaturated fatty acids, we compared effects of fatty acid-free (A1AT-0) and alpha-linoleic acid bound (A1AT-LA) forms of A1AT on lipopolysaccharide (LPS)-induced synthesis of IL-1beta precursor and the release of IL-1beta from human blood neutrophils.	Fatty Acids, Unsaturated	81-108	serpin family A member 1	Homo sapiens	42-46
27588389-1	2016	BACKGROUND: The goal of present investigation is to check the hypothesis that cardioprotective effect of polyunsaturated fatty acids (PUFAs) is mediated by influence on mRNA expression level of the FATP, IL-1ra and GJP43 through stimulation of PPARgamma.	Fatty Acids, Unsaturated	105-132	solute carrier family 27 member 1	Rattus norvegicus	198-202
27588389-1	2016	BACKGROUND: The goal of present investigation is to check the hypothesis that cardioprotective effect of polyunsaturated fatty acids (PUFAs) is mediated by influence on mRNA expression level of the FATP, IL-1ra and GJP43 through stimulation of PPARgamma.	Fatty Acids, Unsaturated	134-139	solute carrier family 27 member 1	Rattus norvegicus	198-202
27588389-1	2016	BACKGROUND: The goal of present investigation is to check the hypothesis that cardioprotective effect of polyunsaturated fatty acids (PUFAs) is mediated by influence on mRNA expression level of the FATP, IL-1ra and GJP43 through stimulation of PPARgamma.	Fatty Acids, Unsaturated	105-132	interleukin 1 receptor antagonist	Rattus norvegicus	204-210
27588389-1	2016	BACKGROUND: The goal of present investigation is to check the hypothesis that cardioprotective effect of polyunsaturated fatty acids (PUFAs) is mediated by influence on mRNA expression level of the FATP, IL-1ra and GJP43 through stimulation of PPARgamma.	Fatty Acids, Unsaturated	134-139	interleukin 1 receptor antagonist	Rattus norvegicus	204-210
27588389-1	2016	BACKGROUND: The goal of present investigation is to check the hypothesis that cardioprotective effect of polyunsaturated fatty acids (PUFAs) is mediated by influence on mRNA expression level of the FATP, IL-1ra and GJP43 through stimulation of PPARgamma.	Fatty Acids, Unsaturated	134-139	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	244-253
27647374-1	2016	Human 15-lipoxygenase-1 (h15-LOX-1 or h12/15-LOX) reacts with polyunsaturated fatty acids and produces bioactive lipid derivatives that are implicated in many important human diseases.	Fatty Acids, Unsaturated	62-89	arachidonate 15-lipoxygenase	Homo sapiens	26-34
27914518-1	2016	Term neonates have high delta-6 desaturase (D6D) activity, which is important for regulating polyunsaturated fatty acid"s (PUFA) nutritional status.	Fatty Acids, Unsaturated	93-119	fatty acid desaturase 2	Homo sapiens	24-42
27914518-1	2016	Term neonates have high delta-6 desaturase (D6D) activity, which is important for regulating polyunsaturated fatty acid"s (PUFA) nutritional status.	Fatty Acids, Unsaturated	93-119	fatty acid desaturase 2	Homo sapiens	44-47
27914518-1	2016	Term neonates have high delta-6 desaturase (D6D) activity, which is important for regulating polyunsaturated fatty acid"s (PUFA) nutritional status.	Fatty Acids, Unsaturated	123-127	fatty acid desaturase 2	Homo sapiens	24-42
27914518-1	2016	Term neonates have high delta-6 desaturase (D6D) activity, which is important for regulating polyunsaturated fatty acid"s (PUFA) nutritional status.	Fatty Acids, Unsaturated	123-127	fatty acid desaturase 2	Homo sapiens	44-47
27852782-1	2016	Fatty acid-binding protein 5 (FABP5) at the blood-brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function.	Fatty Acids, Unsaturated	143-169	fatty acid binding protein 5, epidermal	Mus musculus	0-28
27852782-1	2016	Fatty acid-binding protein 5 (FABP5) at the blood-brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function.	Fatty Acids, Unsaturated	143-169	fatty acid binding protein 5, epidermal	Mus musculus	30-35
27831561-8	2016	n-3 PUFA+curcumin synergistically increased targeted apoptosis in DNA-damaged Lgr5+ stem cells by 4.5-fold compared with control at 12 h and maximally reduced damaged Lgr5+ stem cells at 24 h, down to the level observed in saline-treated mice.	Fatty Acids, Unsaturated	4-8	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	78-82
27831561-8	2016	n-3 PUFA+curcumin synergistically increased targeted apoptosis in DNA-damaged Lgr5+ stem cells by 4.5-fold compared with control at 12 h and maximally reduced damaged Lgr5+ stem cells at 24 h, down to the level observed in saline-treated mice.	Fatty Acids, Unsaturated	4-8	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	167-171
27899364-4	2016	Fatty acid desaturases (FADS) and elongation of very long chain fatty acid protein 5 (ELOVL5) activities were estimated by calculating product to precursor ratios of polyunsaturated fatty acids in complex lipids.	Fatty Acids, Unsaturated	166-193	ELOVL fatty acid elongase 5	Homo sapiens	86-92
27853148-2	2016	Here we show that GPR120, a receptor for polyunsaturated fatty acids, promotes brown fat activation.	Fatty Acids, Unsaturated	41-68	free fatty acid receptor 4	Mus musculus	18-24
27867498-7	2016	These considerations lead us to propose that Dmp1-Cre Mbtps1 cKO osteocytes activate myogenesis by increased release of an activator of muscle PPAR-gamma, for example, PGE2 or sphingosine-1-P, or, by diminished release of an inhibitor of LXR, for example, long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	267-294	dentin matrix protein 1	Mus musculus	45-49
27867498-7	2016	These considerations lead us to propose that Dmp1-Cre Mbtps1 cKO osteocytes activate myogenesis by increased release of an activator of muscle PPAR-gamma, for example, PGE2 or sphingosine-1-P, or, by diminished release of an inhibitor of LXR, for example, long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	267-294	membrane-bound transcription factor peptidase, site 1	Mus musculus	54-60
27867498-7	2016	These considerations lead us to propose that Dmp1-Cre Mbtps1 cKO osteocytes activate myogenesis by increased release of an activator of muscle PPAR-gamma, for example, PGE2 or sphingosine-1-P, or, by diminished release of an inhibitor of LXR, for example, long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	267-294	peroxisome proliferator activated receptor gamma	Mus musculus	143-153
27665999-0	2016	Inhibition of aldo-keto reductase family 1 member B10 by unsaturated fatty acids.	Fatty Acids, Unsaturated	57-80	aldo-keto reductase family 1 member B10	Homo sapiens	14-53
27788154-0	2016	Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERalpha in Breast Cancer Cells.	Fatty Acids, Unsaturated	40-66	estrogen receptor 1	Homo sapiens	87-94
27837747-2	2016	Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays unique properties, thus making their role in inflammation distinct from that of other lipids derived from the same PUFA.	Fatty Acids, Unsaturated	13-40	pumilio RNA binding family member 3	Homo sapiens	42-46
27198176-6	2016	In addition, rDDHD2 was highly specific to DG substrates with a polyunsaturated fatty acid at their sn-2 position.	Fatty Acids, Unsaturated	64-90	DDHD domain containing 2	Rattus norvegicus	13-19
26975734-3	2016	In addition to arachidonic acid, the CYP epoxygenases also metabolize the Omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid and docosahexaenoic acid, to generate bioactive lipid epoxide mediators.	Fatty Acids, Unsaturated	111-116	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	37-40
27788151-7	2016	Our findings indicate that SMS1 has a wider than anticipated role in testis polyunsaturated fatty acid homeostasis and for male fertility.	Fatty Acids, Unsaturated	76-102	sphingomyelin synthase 1	Mus musculus	27-31
27739449-6	2016	Additionally, several 20- and 22- carbon polyunsaturated fatty acids and phospholipid species were significantly elevated in the EGFR mutants compared to non-EGFR mutants.	Fatty Acids, Unsaturated	41-68	epidermal growth factor receptor	Homo sapiens	129-133
27788154-0	2016	Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERalpha in Breast Cancer Cells.	Fatty Acids, Unsaturated	40-66	ELOVL fatty acid elongase 2	Homo sapiens	76-82
27877090-10	2016	LXR pathway and polyunsaturated fatty acid metabolism are two possible mechanisms of FMO3 action in response to dietary TMA precursor.	Fatty Acids, Unsaturated	16-42	flavin containing monooxygenase 3	Gallus gallus	85-89
27752094-1	2016	In some microorganisms, polyunsaturated fatty acids (PUFAs) are biosynthesized by PUFA synthases characterized by tandem acyl carrier proteins (ACPs) in subunit A.	Fatty Acids, Unsaturated	24-51	pumilio RNA binding family member 3	Homo sapiens	53-57
27573698-3	2016	In the present study, endogenously increased levels of n-3 PUFAs in the tumor tissues of omega-3 fatty acid desaturase (fat-1) transgenic mice was associated with a reduction in the growth rate of melanoma xenografts.	Fatty Acids, Unsaturated	59-64	FAT atypical cadherin 1	Mus musculus	120-125
28533737-0	2016	The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo.	Fatty Acids, Unsaturated	64-90	adrenergic receptor, alpha 1d	Mus musculus	4-32
28533737-8	2016	RESULTS: We identified previously unrecognized metabolic responses to alpha1A activation, most notably broad reduction in the abundance of polyunsaturated fatty acids (PUFAs) and endocannabinoids (ECs).	Fatty Acids, Unsaturated	139-166	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	70-77
28533737-8	2016	RESULTS: We identified previously unrecognized metabolic responses to alpha1A activation, most notably broad reduction in the abundance of polyunsaturated fatty acids (PUFAs) and endocannabinoids (ECs).	Fatty Acids, Unsaturated	168-173	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	70-77
26335394-9	2016	PUFAs: arachidonic acid (AA), EPA and DHA and their various products modulate not only inflammation and immune response but also possess actions on various genes, nuclear factors, cyclic AMP and GMP, G-protein coupled receptors (GPRs), hypothalamic neurotransmitters, hormones, cytokines and enzymes, and interact with nitric oxide, carbon monoxide, and hydrogen sulfide to regulate their formation and action and to form new compounds that have several biological actions.	Fatty Acids, Unsaturated	0-5	5'-nucleotidase, cytosolic II	Homo sapiens	195-198
27210509-1	2016	OBJECTIVES: The goal of the study described here was to determine whether dietary omega-3 polyunsaturated fatty acid (PUFA) intake modulates the association between ApoB Ins/Del polymorphism and obesity in type 2 diabetic patients.	Fatty Acids, Unsaturated	118-122	apolipoprotein B	Homo sapiens	165-169
27685528-2	2016	Activation of PPARgamma by polyunsaturated fatty acids (PUFAs) inhibits growth and proliferationof tumor cells.	Fatty Acids, Unsaturated	27-54	peroxisome proliferator activated receptor gamma	Homo sapiens	14-23
27685528-2	2016	Activation of PPARgamma by polyunsaturated fatty acids (PUFAs) inhibits growth and proliferationof tumor cells.	Fatty Acids, Unsaturated	56-61	peroxisome proliferator activated receptor gamma	Homo sapiens	14-23
27312217-5	2016	After 1-day HFD administration UFA, when compared to SFA, reduced plasma triacylglycerol (TAG) level and the activities of the lipogenic enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), a decreased activity of the citrate carrier (CIC), a mitochondrial protein linked to lipogenesis, was also detected.	Fatty Acids, Unsaturated	31-34	fatty acid synthase	Rattus norvegicus	178-197
27312217-5	2016	After 1-day HFD administration UFA, when compared to SFA, reduced plasma triacylglycerol (TAG) level and the activities of the lipogenic enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), a decreased activity of the citrate carrier (CIC), a mitochondrial protein linked to lipogenesis, was also detected.	Fatty Acids, Unsaturated	31-34	fatty acid synthase	Rattus norvegicus	199-202
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Fatty Acids, Unsaturated	231-258	phosphorylase kinase catalytic subunit gamma 2	Homo sapiens	86-109
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Fatty Acids, Unsaturated	231-258	phosphorylase kinase catalytic subunit gamma 2	Homo sapiens	111-116
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Fatty Acids, Unsaturated	231-258	pumilio RNA binding family member 3	Homo sapiens	260-264
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Fatty Acids, Unsaturated	231-258	pumilio RNA binding family member 3	Homo sapiens	327-331
26914447-6	2016	The polyunsaturated fatty acids docosahexaenoic acid, alpha-linolenic acid and eicosapentaenoic acid facilitated opening of the human M-channel, comprised of the heteromeric human KV 7.2/3 channel expressed in Xenopus oocytes, by shifting the conductance-vs.-voltage curve towards more negative voltages (by -7.4 to -11.3 mV by 70 mum).	Fatty Acids, Unsaturated	4-31	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	180-188
26286349-9	2016	CONCLUSION: This is the first study that demonstrates the ability of the human fecal microbiota to convert polyunsaturated fatty acids from walnuts to c9,t11 CLA as a potential chemopreventive metabolite.	Fatty Acids, Unsaturated	107-134	complement C9	Homo sapiens	151-161
27197070-0	2016	Impact of Genetic and Epigenetic Variations Within the FADS Cluster on the Composition and Metabolism of Polyunsaturated Fatty Acids in Prostate Cancer.	Fatty Acids, Unsaturated	105-132	stearoyl-CoA desaturase	Homo sapiens	55-59
27601985-9	2016	In both electrophysiological and behavioral experiments, the effect of a diet with a high omega3 to omega6 PUFA diet ratio was completely blocked by treatment with a CB1 receptor antagonist.	Fatty Acids, Unsaturated	107-111	cannabinoid receptor 1 (brain)	Mus musculus	166-169
27372435-0	2016	Radical formation in the FMN-photosensitized reactions of unsaturated fatty acids bearing double bonds at different positions.	Fatty Acids, Unsaturated	58-81	formin 1	Homo sapiens	25-28
27286171-1	2016	Polyunsaturated fatty acids (PUFAs) undergo cytochrome P450 (CYP)-dependent oxidation to epoxides that modulate important physiological functions, including vasoactivity, inflammation, nociception, proliferation and viability.	Fatty Acids, Unsaturated	0-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	44-59
26970560-0	2016	A post-GWAS confirming the SCD gene associated with milk medium- and long-chain unsaturated fatty acids in Chinese Holstein population.	Fatty Acids, Unsaturated	80-103	stearoyl-CoA desaturase	Bos taurus	27-30
26995463-4	2016	We summarize evidence for cholesterol-dependent ordered lipids serving to regulate the store-operated Ca(2+) channel, Orai1, and we describe the sensitivity of Orai1 coupling to the ER Ca(2+) sensor, STIM1, to inhibition by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	224-251	ORAI calcium release-activated calcium modulator 1	Homo sapiens	160-165
27853717-12	2016	Donkey milk was characterised by high lactose content, low caseins, low fat, higher levels of unsaturated fatty acids compared to ruminant milks.	Fatty Acids, Unsaturated	94-117	Weaning weight-maternal milk	Bos taurus	7-11
27281482-0	2016	Polyunsaturated fatty acids inhibit Kv1.4 by interacting with positively charged extracellular pore residues.	Fatty Acids, Unsaturated	0-27	potassium voltage-gated channel subfamily A member 4	Homo sapiens	36-41
27281482-1	2016	Polyunsaturated fatty acids (PUFAs) modulate voltage-gated K(+) channel inactivation by an unknown site and mechanism.	Fatty Acids, Unsaturated	0-27	potassium voltage-gated channel subfamily D member 3	Homo sapiens	45-71
27281482-1	2016	Polyunsaturated fatty acids (PUFAs) modulate voltage-gated K(+) channel inactivation by an unknown site and mechanism.	Fatty Acids, Unsaturated	29-34	potassium voltage-gated channel subfamily D member 3	Homo sapiens	45-71
27464460-0	2016	The effects of trans-fatty acids on TAG regulation in mice depend on dietary unsaturated fatty acids.	Fatty Acids, Unsaturated	77-100	temporal alpha-galactosidase	Mus musculus	36-39
27464460-8	2016	In brief, the effects of low levels of TFA on liver and serum TAG regulation in mice depend on the dietary proportions of n-3, n-6 and n-9 UFA.	Fatty Acids, Unsaturated	139-142	temporal alpha-galactosidase	Mus musculus	62-65
27286171-1	2016	Polyunsaturated fatty acids (PUFAs) undergo cytochrome P450 (CYP)-dependent oxidation to epoxides that modulate important physiological functions, including vasoactivity, inflammation, nociception, proliferation and viability.	Fatty Acids, Unsaturated	0-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	61-64
27472366-2	2016	In this regard, the central role of polyunsaturated fatty acids (PUFAs), and particularly n-3 PUFAs, is emerging considering that epidemiological evidences have established a negative correlation between n-3 PUFA consumption and development of mood disorders.	Fatty Acids, Unsaturated	36-63	pumilio RNA binding family member 3	Homo sapiens	65-69
27050409-6	2016	Moreover, the NLK g.630426A&gt;G SNP was significantly associated with IMF content and the fatty composition of arachidic, linoleic, as well as polyunsaturated FA and omega6 FA levels.	Fatty Acids, Unsaturated	144-162	nemo like kinase	Sus scrofa	14-17
27358009-0	2016	The role of AHR-inducible cytochrome P450s in metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	60-87	aryl hydrocarbon receptor	Homo sapiens	12-15
27358009-3	2016	We demonstrated that TCDD treatment markedly increases the levels of several epoxides and diol metabolites of the epoxides of both omega-6 and omega-3 polyunsaturated fatty acids (PUFA) in the liver and lungs of mice, in an aryl hydrocarbon receptor-dependent fashion, and most likely via the activities of the CYP1 family members.	Fatty Acids, Unsaturated	180-184	aryl-hydrocarbon receptor	Mus musculus	224-249
27358009-7	2016	This is of potential relevance to carcinogenesis by AHR agonists in the human, since the human population is exposed to widely varying omega-6: omega-3 PUFA ratios in the diet.	Fatty Acids, Unsaturated	152-156	aryl hydrocarbon receptor	Homo sapiens	52-55
27208083-0	2016	3,3",4,4",5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats.	Fatty Acids, Unsaturated	114-137	pyruvate carboxylase	Rattus norvegicus	33-36
27208083-7	2016	The ratios of several epoxides to diol metabolites formed via the cytochrome P450 (P450) monooxygenase/soluble epoxide hydrolase (sEH) pathway from polyunsaturated fatty acids displayed a dose-dependent decrease in the liver and plasma, whereas levels of oxylipins formed by other metabolic pathways were generally not altered by PCB 126 treatment.	Fatty Acids, Unsaturated	148-175	epoxide hydrolase 2	Rattus norvegicus	130-133
27208083-7	2016	The ratios of several epoxides to diol metabolites formed via the cytochrome P450 (P450) monooxygenase/soluble epoxide hydrolase (sEH) pathway from polyunsaturated fatty acids displayed a dose-dependent decrease in the liver and plasma, whereas levels of oxylipins formed by other metabolic pathways were generally not altered by PCB 126 treatment.	Fatty Acids, Unsaturated	148-175	pyruvate carboxylase	Rattus norvegicus	330-333
27128111-0	2016	Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1.	Fatty Acids, Unsaturated	37-60	nuclear receptor subfamily 4 group A member 2	Homo sapiens	92-97
27226632-4	2016	These phenotypes were associated with concomitant alterations in the tissue levels of omega3 polyunsaturated fatty acid (PUFA) metabolites, which had the capacity to reduce the expression of pro-inflammatory and Th1/Th17-type cytokines in dendritic cells or lymph node cells.	Fatty Acids, Unsaturated	93-119	negative elongation factor complex member C/D, Th1l	Mus musculus	212-215
27226632-4	2016	These phenotypes were associated with concomitant alterations in the tissue levels of omega3 polyunsaturated fatty acid (PUFA) metabolites, which had the capacity to reduce the expression of pro-inflammatory and Th1/Th17-type cytokines in dendritic cells or lymph node cells.	Fatty Acids, Unsaturated	121-125	negative elongation factor complex member C/D, Th1l	Mus musculus	212-215
27128111-2	2016	A recent metabolomics study identified unsaturated fatty acids, including arachidonic acid and docosahexaenoic acid (DHA), that interact with the ligand-binding domain (LBD) of a related orphan receptor, Nur77/NR4A1.	Fatty Acids, Unsaturated	39-62	nuclear receptor subfamily 4 group A member 1	Homo sapiens	204-209
27128111-2	2016	A recent metabolomics study identified unsaturated fatty acids, including arachidonic acid and docosahexaenoic acid (DHA), that interact with the ligand-binding domain (LBD) of a related orphan receptor, Nur77/NR4A1.	Fatty Acids, Unsaturated	39-62	nuclear receptor subfamily 4 group A member 1	Homo sapiens	210-215
27128111-4	2016	Here, we show that unsaturated fatty acids also interact with the Nurr1 LBD, and solution NMR spectroscopy reveals the binding epitope of DHA at its putative ligand-binding pocket.	Fatty Acids, Unsaturated	19-42	nuclear receptor subfamily 4 group A member 2	Homo sapiens	66-71
27391332-8	2016	RESULTS: the treatment of preadipocytes with unsaturated fatty acids significantly reduced the expression of the BSCL2 transcript without exon 7 by 34 to 63%.	Fatty Acids, Unsaturated	45-68	BSCL2 lipid droplet biogenesis associated, seipin	Homo sapiens	113-118
27383786-8	2016	This is explained by an increase in microsomal phospholipids containing polyunsaturated fatty acids, linked to an LXRalpha-dependent increase in expression of enzymes mediating phosphatidylcholine biosynthesis and incorporation of polyunsaturated fatty acids into phospholipids.	Fatty Acids, Unsaturated	72-99	nuclear receptor subfamily 1, group H, member 3	Mus musculus	114-122
27383786-8	2016	This is explained by an increase in microsomal phospholipids containing polyunsaturated fatty acids, linked to an LXRalpha-dependent increase in expression of enzymes mediating phosphatidylcholine biosynthesis and incorporation of polyunsaturated fatty acids into phospholipids.	Fatty Acids, Unsaturated	231-258	nuclear receptor subfamily 1, group H, member 3	Mus musculus	114-122
27403993-5	2016	Gclm KO mice also exhibit constitutive activation of liver AMP-activated protein kinase (AMPK) pathway and nuclear factor-erythroid 2-related factor 2 target genes, and show enhanced ethanol clearance, altered hepatic lipid profiles in favor of increased levels of polyunsaturated fatty acids and concordant changes in expression of genes associated with lipogenesis and fatty acid oxidation.	Fatty Acids, Unsaturated	265-292	glutamate-cysteine ligase, modifier subunit	Mus musculus	0-4
27072368-0	2016	Beef Fat Enriched with Polyunsaturated Fatty Acid Biohydrogenation Products Improves Insulin Sensitivity Without Altering Dyslipidemia in Insulin Resistant JCR:LA-cp Rats.	Fatty Acids, Unsaturated	23-49	insulin	Bos taurus	85-92
29648713-1	2016	Study results indicate that a diet rich in polyunsaturated fatty acids omega-3 (PUFA n-3) exerts favorable effect on human health, accounting for reduced cardiovascular morbidity and mortality.	Fatty Acids, Unsaturated	43-70	pumilio RNA binding family member 3	Homo sapiens	80-84
27197628-2	2016	Thus, our objective was to evaluate the effect of long-term consumption of weakly oxidised PUFA from flaxseed oil on oxidative stress biomarkers of LDL-receptor(-/-) mice.	Fatty Acids, Unsaturated	91-95	low density lipoprotein receptor	Mus musculus	148-160
26967968-3	2016	For example, a direct interaction between membrane phospholipids and the pore-forming protein mixed lineage kinase domain-like (MLKL) is needed for the execution of necroptosis, while the oxidative destruction of membrane polyunsaturated fatty acids (PUFAs), following the inactivation of glutathione peroxidase 4 (GPX4), is a requisite gateway to ferroptosis.	Fatty Acids, Unsaturated	222-249	mixed lineage kinase domain like pseudokinase	Homo sapiens	128-132
26967968-3	2016	For example, a direct interaction between membrane phospholipids and the pore-forming protein mixed lineage kinase domain-like (MLKL) is needed for the execution of necroptosis, while the oxidative destruction of membrane polyunsaturated fatty acids (PUFAs), following the inactivation of glutathione peroxidase 4 (GPX4), is a requisite gateway to ferroptosis.	Fatty Acids, Unsaturated	222-249	glutathione peroxidase 4	Homo sapiens	289-313
26967968-3	2016	For example, a direct interaction between membrane phospholipids and the pore-forming protein mixed lineage kinase domain-like (MLKL) is needed for the execution of necroptosis, while the oxidative destruction of membrane polyunsaturated fatty acids (PUFAs), following the inactivation of glutathione peroxidase 4 (GPX4), is a requisite gateway to ferroptosis.	Fatty Acids, Unsaturated	222-249	glutathione peroxidase 4	Homo sapiens	315-319
27179851-11	2016	Compared with the CON, the milk fat from cows fed any of the dietary supplements had a higher concentration of unsaturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids; conversely, the saturated fatty acids levels in milk fat were 30.5% lower.	Fatty Acids, Unsaturated	111-134	Weaning weight-maternal milk	Bos taurus	27-31
27179851-11	2016	Compared with the CON, the milk fat from cows fed any of the dietary supplements had a higher concentration of unsaturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids; conversely, the saturated fatty acids levels in milk fat were 30.5% lower.	Fatty Acids, Unsaturated	169-196	Weaning weight-maternal milk	Bos taurus	27-31
26888796-1	2016	BACKGROUND: GPR120 (FFAR4) is a G-protein coupled receptor implicated in the development of obesity and the antiinflammatory and insulin-sensitizing effects of omega-3 (omega-3) polyunsaturated fatty acids.	Fatty Acids, Unsaturated	178-205	free fatty acid receptor 4	Mus musculus	12-18
26888796-1	2016	BACKGROUND: GPR120 (FFAR4) is a G-protein coupled receptor implicated in the development of obesity and the antiinflammatory and insulin-sensitizing effects of omega-3 (omega-3) polyunsaturated fatty acids.	Fatty Acids, Unsaturated	178-205	free fatty acid receptor 4	Mus musculus	20-25
27297560-4	2016	RESULTS: Under seed-specific overexpression of ZmSAD1 in Arabidopsis, the stearic acid content and the ratio of saturated to unsaturated fatty acids in the seeds were significantly decreased relative to those in the control.	Fatty Acids, Unsaturated	125-148	shikimate dehydrogenase 1	Zea mays	47-53
27282869-8	2016	Our findings suggest that neuronal LPL is involved in the regulation of body weight and composition in response to either the change in quantity (HF feeding) or quality (n-3 PUFA-enriched) of dietary fat.	Fatty Acids, Unsaturated	174-178	lipoprotein lipase	Mus musculus	35-38
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	227-232	fatty acid desaturase 1	Mus musculus	66-89
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	227-232	fatty acid desaturase 1	Mus musculus	91-96
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	227-232	fatty acid desaturase 2	Mus musculus	102-107
27382320-8	2016	Importantly, PUFA levels measured in brain and liver phospholipid fractions of Fads1 KO mice were consistent with decreased D5D activity and normal D6D activity.	Fatty Acids, Unsaturated	13-17	fatty acid desaturase 1	Mus musculus	79-84
27036610-10	2016	Total PUFA omega-6 (beta = 28.961; P = 0.002) and 18:2 omega-6 (beta = 0.259, P = 0.006) were positively associated with the adiponectin.	Fatty Acids, Unsaturated	6-10	adiponectin, C1Q and collagen domain containing	Homo sapiens	125-136
27223066-5	2016	In this study, we have identified Sterol-CoA desaturase-1 (SCD1) which is the rate-limiting enzyme of unsaturated fatty acid synthesis, universally and highly expressed in lung adenocarcinoma and was required for the cell proliferation, migration and invasion.	Fatty Acids, Unsaturated	102-124	stearoyl-CoA desaturase	Homo sapiens	34-57
27223066-5	2016	In this study, we have identified Sterol-CoA desaturase-1 (SCD1) which is the rate-limiting enzyme of unsaturated fatty acid synthesis, universally and highly expressed in lung adenocarcinoma and was required for the cell proliferation, migration and invasion.	Fatty Acids, Unsaturated	102-124	stearoyl-CoA desaturase	Homo sapiens	59-63
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	198-225	fatty acid desaturase 1	Mus musculus	0-18
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	198-225	fatty acid desaturase 2	Mus musculus	29-47
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	198-225	fatty acid desaturase 2	Mus musculus	49-52
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	198-225	fatty acid desaturase 1	Mus musculus	66-89
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	198-225	fatty acid desaturase 1	Mus musculus	91-96
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	198-225	fatty acid desaturase 2	Mus musculus	102-107
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	227-232	fatty acid desaturase 1	Mus musculus	0-18
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	227-232	fatty acid desaturase 2	Mus musculus	29-47
27382320-1	2016	Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for omega3, omega6, and omega9 polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	227-232	fatty acid desaturase 2	Mus musculus	49-52
27297560-5	2016	Conversely, in transgenic ZmSAD1 RNAi Arabidopsis seeds, the contents of stearic acid and long-chain saturated acids and the ratio of saturated to unsaturated fatty acids were significantly increased; in addition, the oleic acid content was significantly decreased.	Fatty Acids, Unsaturated	147-170	shikimate dehydrogenase 1	Zea mays	26-32
27297560-6	2016	More importantly, transgenic ZmSAD1 maize that expressed high levels of ZmSAD1 in its mature seeds showed reduced stearic acid content (1.57 %) and a lower saturated to unsaturated fatty acid ratio (20.40 %) relative to those (1.64 % and 20.61 %, respectively) of the control.	Fatty Acids, Unsaturated	169-191	shikimate dehydrogenase 1	Zea mays	29-35
27297560-6	2016	More importantly, transgenic ZmSAD1 maize that expressed high levels of ZmSAD1 in its mature seeds showed reduced stearic acid content (1.57 %) and a lower saturated to unsaturated fatty acid ratio (20.40 %) relative to those (1.64 % and 20.61 %, respectively) of the control.	Fatty Acids, Unsaturated	169-191	shikimate dehydrogenase 1	Zea mays	72-78
27297560-7	2016	Conversely, down-regulation of ZmSAD1 in maize resulted in increased levels of stearic acid (1.78 %), long-chain saturated acids (0.85 %) and the ratio of saturated to unsaturated fatty acids (21.54 %) relative to those (1.64 %, 0.74 %, and 20.61 %, respectively) of the control, whereas the oleic acid (32.01 %) level was significantly decreased relative to that (32.68 %) of the control.	Fatty Acids, Unsaturated	168-191	shikimate dehydrogenase 1	Zea mays	31-37
27375435-9	2016	In conclusion, our data indicate that the substitution of saturated by unsaturated fatty acids in the diet has beneficial effects on modulation of hypothalamic inflammation and function in obesity, underlying, at hypothalamic level, the interaction among insulin and/or leptin resistance, AMPK activation and hyperphagia.	Fatty Acids, Unsaturated	71-94	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	289-293
27184288-10	2016	Partially substituting UFA for carbohydrate has been associated with improved insulin sensitivity, lipoprotein lipids, and blood pressure.	Fatty Acids, Unsaturated	23-26	insulin	Homo sapiens	78-85
27321337-10	2016	Even after adjustment for age, SBP or DBP, UAE, and WHR in all models, inverse associations between adiponectin levels and intake of total SFA and MUFA and polyunsaturated fatty acid fractions were observed.	Fatty Acids, Unsaturated	156-182	adiponectin, C1Q and collagen domain containing	Homo sapiens	100-111
27269715-0	2016	Association of polyunsaturated fatty acids in breast milk with fatty acid desaturase gene polymorphisms among Chinese lactating mothers.	Fatty Acids, Unsaturated	15-42	stearoyl-CoA desaturase	Homo sapiens	63-84
27269715-1	2016	BACKGROUND: The fatty acid desaturase (FADS) controls polyunsaturated fatty acid (PUFA) synthesis in human tissues and breast milk.	Fatty Acids, Unsaturated	54-80	stearoyl-CoA desaturase	Homo sapiens	16-37
27269715-1	2016	BACKGROUND: The fatty acid desaturase (FADS) controls polyunsaturated fatty acid (PUFA) synthesis in human tissues and breast milk.	Fatty Acids, Unsaturated	54-80	stearoyl-CoA desaturase	Homo sapiens	39-43
27269715-1	2016	BACKGROUND: The fatty acid desaturase (FADS) controls polyunsaturated fatty acid (PUFA) synthesis in human tissues and breast milk.	Fatty Acids, Unsaturated	82-86	stearoyl-CoA desaturase	Homo sapiens	16-37
27269715-1	2016	BACKGROUND: The fatty acid desaturase (FADS) controls polyunsaturated fatty acid (PUFA) synthesis in human tissues and breast milk.	Fatty Acids, Unsaturated	82-86	stearoyl-CoA desaturase	Homo sapiens	39-43
27279075-4	2016	Lipid accumulation induced by unsaturated fatty acid (UFA; arachidonic acid:oleic acid = 1:1) in hepatocytes, was attenuated in TLR7 and autophagy activation.	Fatty Acids, Unsaturated	30-52	toll-like receptor 7	Mus musculus	128-132
27279075-4	2016	Lipid accumulation induced by unsaturated fatty acid (UFA; arachidonic acid:oleic acid = 1:1) in hepatocytes, was attenuated in TLR7 and autophagy activation.	Fatty Acids, Unsaturated	54-57	toll-like receptor 7	Mus musculus	128-132
27279075-5	2016	Interestingly, TLR7 activation attenuated UFA-induced lipid peroxidation products, such as malondialdehyde (MDA) and 4-Hydroxy-2-Nonenal (4-HNE).	Fatty Acids, Unsaturated	42-45	toll-like receptor 7	Mus musculus	15-19
27279075-7	2016	MDA and 4-HNE induced 2-folds lipid accumulation in UFA-treated hepatocytes via blockade of the TLR7 signaling pathway"s IGF-1 release compared to only UFA-treated hepatocytes.	Fatty Acids, Unsaturated	52-55	toll-like receptor 7	Mus musculus	96-100
27279075-7	2016	MDA and 4-HNE induced 2-folds lipid accumulation in UFA-treated hepatocytes via blockade of the TLR7 signaling pathway"s IGF-1 release compared to only UFA-treated hepatocytes.	Fatty Acids, Unsaturated	52-55	insulin-like growth factor 1	Mus musculus	121-126
27279075-7	2016	MDA and 4-HNE induced 2-folds lipid accumulation in UFA-treated hepatocytes via blockade of the TLR7 signaling pathway"s IGF-1 release compared to only UFA-treated hepatocytes.	Fatty Acids, Unsaturated	152-155	toll-like receptor 7	Mus musculus	96-100
26774606-3	2016	Understanding the interactions of PLA2s is crucial since these enzymes are the upstream regulators of the eicosanoid pathway liberating free arachidonic acid (AA) and other polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	173-200	phospholipase A2 group IIA	Homo sapiens	34-39
27002347-5	2016	Downregulation of miR-26a/b and their host genes in GMEC decreased the expression of genes relate to fatty acid synthesis (PPARG, LXRA, SREBF1, FASN, ACACA, GPAM, LPIN1, DGAT1 and SCD1), triacylglycerol accumulation and unsaturated fatty acid synthesis.	Fatty Acids, Unsaturated	220-242	microRNA 26a	Capra hircus	18-25
26774606-3	2016	Understanding the interactions of PLA2s is crucial since these enzymes are the upstream regulators of the eicosanoid pathway liberating free arachidonic acid (AA) and other polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	202-206	phospholipase A2 group IIA	Homo sapiens	34-39
26887439-7	2016	PUFA-induced cytotoxicity was dependent on caspase and unfolded protein response (UPR) sensor proteins inositol requiring 1alpha and protein kinase R-like endoplasmic reticulum kinase, suggesting that excess PUFAs trigger UPR-mediated apoptosis.	Fatty Acids, Unsaturated	0-4	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	103-128
26947306-2	2016	Although the transcriptional regulatory mechanism of SCD1 via polyunsaturated fatty acids (PUFA) has been extensively explored in nonruminants, the existence of such mechanism in ruminant mammary gland remains unknown.	Fatty Acids, Unsaturated	62-89	stearoyl-CoA desaturase	Capra hircus	53-57
26887439-0	2016	Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	83-110	lysophosphatidylcholine acyltransferase 1	Mus musculus	0-41
26947306-2	2016	Although the transcriptional regulatory mechanism of SCD1 via polyunsaturated fatty acids (PUFA) has been extensively explored in nonruminants, the existence of such mechanism in ruminant mammary gland remains unknown.	Fatty Acids, Unsaturated	91-95	stearoyl-CoA desaturase	Capra hircus	53-57
27035965-3	2016	TREK/TRAAK KO mice display altered phenotypes related to nociception, neuroprotection afforded by polyunsaturated fatty acids, learning and memory, mood control, and sensitivity to general anesthetics.	Fatty Acids, Unsaturated	98-125	potassium channel, subfamily K, member 4	Mus musculus	5-10
27021137-8	2016	These results suggest that the increased saturated LPC/unsaturated LPC (and saturated fatty acid/unsaturated fatty acid) ratios associated with SCD1 down-regulation could be regarded as biomarkers of colitis, and celastrol alleviates DSS-induced colitis partially via up-regulation of SCD1, restoring the altered balance between stearic acid- and oleic acid-derived lipid species, which plays an important role in alleviating colitis.	Fatty Acids, Unsaturated	97-119	stearoyl-Coenzyme A desaturase 1	Mus musculus	144-148
26912491-1	2016	BACKGROUND: Specific single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficiency of enzymes that are responsible for the conversion of polyunsaturated fatty acids (PUFAs) into their long-chain active form.	Fatty Acids, Unsaturated	190-217	stearoyl-CoA desaturase	Homo sapiens	67-88
26712506-4	2016	Here, we present evidence that cytochrome b5 reductase 1 (CBR1) increases the levels of unsaturated fatty acids, which stimulate PM H(+)-ATPase activity and thus lead to rhizosphere acidification.	Fatty Acids, Unsaturated	88-111	NADH:cytochrome B5 reductase 1	Arabidopsis thaliana	31-56
26712506-4	2016	Here, we present evidence that cytochrome b5 reductase 1 (CBR1) increases the levels of unsaturated fatty acids, which stimulate PM H(+)-ATPase activity and thus lead to rhizosphere acidification.	Fatty Acids, Unsaturated	88-111	NADH:cytochrome B5 reductase 1	Arabidopsis thaliana	58-62
26712506-5	2016	CBR1-overexpressing (CBR1-OX) Arabidopsis thaliana plants had higher levels of unsaturated fatty acids (18:2 and 18:3), higher PM H(+)-ATPase activity, and lower rhizosphere pH than wild-type plants.	Fatty Acids, Unsaturated	79-102	NADH:cytochrome B5 reductase 1	Arabidopsis thaliana	0-4
26712506-5	2016	CBR1-overexpressing (CBR1-OX) Arabidopsis thaliana plants had higher levels of unsaturated fatty acids (18:2 and 18:3), higher PM H(+)-ATPase activity, and lower rhizosphere pH than wild-type plants.	Fatty Acids, Unsaturated	79-102	NADH:cytochrome B5 reductase 1	Arabidopsis thaliana	21-25
26712506-6	2016	By contrast, cbr1 loss-of-function mutant plants showed lower levels of unsaturated fatty acids and lower PM H(+)-ATPase activity but higher rhizosphere pH.	Fatty Acids, Unsaturated	72-95	NADH:cytochrome B5 reductase 1	Arabidopsis thaliana	13-17
26712506-7	2016	Reduced PM H(+)-ATPase activity in cbr1 could be restored in vitro by addition of unsaturated fatty acids.	Fatty Acids, Unsaturated	82-105	NADH:cytochrome B5 reductase 1	Arabidopsis thaliana	35-39
26712506-9	2016	We propose that CBR1 has a crucial role in increasing the levels of unsaturated fatty acids, which activate the PM H(+)-ATPase and thus reduce rhizosphere pH.	Fatty Acids, Unsaturated	68-91	NADH:cytochrome B5 reductase 1	Arabidopsis thaliana	16-20
28071002-3	2016	It represents an oxidative degradation of polyunsaturated fatty acids incorporated in cell membrane lipids or in lipoproteins, but also in vegetables and food oils rich in PUFA n-3.	Fatty Acids, Unsaturated	42-69	pumilio RNA binding family member 3	Homo sapiens	172-176
26912491-1	2016	BACKGROUND: Specific single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficiency of enzymes that are responsible for the conversion of polyunsaturated fatty acids (PUFAs) into their long-chain active form.	Fatty Acids, Unsaturated	190-217	stearoyl-CoA desaturase	Homo sapiens	90-94
26912491-1	2016	BACKGROUND: Specific single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficiency of enzymes that are responsible for the conversion of polyunsaturated fatty acids (PUFAs) into their long-chain active form.	Fatty Acids, Unsaturated	219-224	stearoyl-CoA desaturase	Homo sapiens	67-88
26912491-1	2016	BACKGROUND: Specific single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficiency of enzymes that are responsible for the conversion of polyunsaturated fatty acids (PUFAs) into their long-chain active form.	Fatty Acids, Unsaturated	219-224	stearoyl-CoA desaturase	Homo sapiens	90-94
26806391-0	2016	The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans.	Fatty Acids, Unsaturated	67-94	NADH-cytochrome b5 reductase	Caenorhabditis elegans	28-34
26791484-1	2016	GPR120 (free fatty acid receptor-4) is a G protein-coupled receptor for medium- and long-chain unsaturated fatty acids, including omega-3 fatty acids.	Fatty Acids, Unsaturated	95-118	free fatty acid receptor 4	Homo sapiens	0-6
25824304-3	2016	Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN.	Fatty Acids, Unsaturated	183-209	epoxide hydrolase 2	Homo sapiens	8-27
27042297-4	2016	RESULTS: Using functional genomics, we identified stearoyl-CoA desaturase (SCD), an enzyme that controls synthesis of unsaturated fatty acids, as essential in breast and prostate cancer cells.	Fatty Acids, Unsaturated	118-141	stearoyl-CoA desaturase	Homo sapiens	50-73
27042297-4	2016	RESULTS: Using functional genomics, we identified stearoyl-CoA desaturase (SCD), an enzyme that controls synthesis of unsaturated fatty acids, as essential in breast and prostate cancer cells.	Fatty Acids, Unsaturated	118-141	stearoyl-CoA desaturase	Homo sapiens	75-78
26868492-2	2016	12-Lipoxygenase (12-LO, gene expressed as ALOX12 in humans and 12-Lo in rodents in this manuscript) produces proinflammatory metabolites such as 12(S)-hydroxyeicosatetraenoic acids through dioxygenation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	206-233	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	42-48
26850107-5	2016	PlsX is an acyl-ACP : phosphate transacylase that links the fatty acid synthase II (FASII) pathway to the phospholipid synthesis pathway, and is therefore central to the movement of unsaturated fatty acids into the membrane.	Fatty Acids, Unsaturated	182-205	phosphate acyltransferase PlsX	Streptococcus mutans UA159	0-4
25824304-3	2016	Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN.	Fatty Acids, Unsaturated	183-209	epoxide hydrolase 2	Homo sapiens	29-34
25824304-3	2016	Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN.	Fatty Acids, Unsaturated	183-209	epoxide hydrolase 2	Homo sapiens	119-144
25824304-3	2016	Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN.	Fatty Acids, Unsaturated	183-209	epoxide hydrolase 2	Homo sapiens	146-149
25824304-3	2016	Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN.	Fatty Acids, Unsaturated	211-215	epoxide hydrolase 2	Homo sapiens	8-27
25824304-3	2016	Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN.	Fatty Acids, Unsaturated	211-215	epoxide hydrolase 2	Homo sapiens	29-34
25824304-3	2016	Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN.	Fatty Acids, Unsaturated	211-215	epoxide hydrolase 2	Homo sapiens	119-144
25824304-3	2016	Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN.	Fatty Acids, Unsaturated	211-215	epoxide hydrolase 2	Homo sapiens	146-149
26828067-2	2016	Unexpectedly, we found that transgenic mice globally overexpressing human sPLA2-X (PLA2G10-Tg) displayed striking immunosuppressive and lean phenotypes with lymphopenia and increased M2-like macrophages, accompanied by marked elevation of free omega3 polyunsaturated fatty acids (PUFAs) and their metabolites.	Fatty Acids, Unsaturated	251-278	phospholipase A2 group X	Homo sapiens	74-81
27053614-0	2016	[Unsaturated fatty acid of Actinidia chinesis Planch seed oil enhances the antioxidative stress ability of rats with pulmonary fibrosis through activating Keap 1/Nrf 2 signaling pathway].	Fatty Acids, Unsaturated	1-23	Kelch-like ECH-associated protein 1	Rattus norvegicus	155-161
27053614-0	2016	[Unsaturated fatty acid of Actinidia chinesis Planch seed oil enhances the antioxidative stress ability of rats with pulmonary fibrosis through activating Keap 1/Nrf 2 signaling pathway].	Fatty Acids, Unsaturated	1-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	162-167
26828067-2	2016	Unexpectedly, we found that transgenic mice globally overexpressing human sPLA2-X (PLA2G10-Tg) displayed striking immunosuppressive and lean phenotypes with lymphopenia and increased M2-like macrophages, accompanied by marked elevation of free omega3 polyunsaturated fatty acids (PUFAs) and their metabolites.	Fatty Acids, Unsaturated	280-285	phospholipase A2 group X	Homo sapiens	74-81
26833026-4	2016	Lpcat3-dependent incorporation of polyunsaturated fatty acids into phospholipids is required for the efficient transport of dietary lipids into enterocytes.	Fatty Acids, Unsaturated	34-61	lysophosphatidylcholine acyltransferase 3	Mus musculus	0-6
26960694-7	2016	Forty genomic regions explained more than 1 % of the additive variance for the polyunsaturated fatty acids group, which are related to the total polyunsaturated fatty acids, C20:4 n-6, C18:2 cis-9 cis12 n-6, C18:3 n-3, C18:3 n-6, C22:6 n-3 and C20:3 n-6 cis-8 cis-11 cis-14.	Fatty Acids, Unsaturated	79-106	complement C9	Homo sapiens	185-196
26856322-3	2016	The aim of this study is to determine whether n-3 PUFA may improve inflammatory responses by neutralizing SphK1 signaling.	Fatty Acids, Unsaturated	50-54	sphingosine kinase 1	Rattus norvegicus	106-111
26937141-0	2016	Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation.	Fatty Acids, Unsaturated	33-59	NLR family, pyrin domain containing 3	Mus musculus	86-113
26937141-0	2016	Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation.	Fatty Acids, Unsaturated	33-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-168
26937141-8	2016	In contrast, PUFA docosahexaenoic acid (DHA) had the potential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation.	Fatty Acids, Unsaturated	13-17	NLR family, pyrin domain containing 3	Mus musculus	74-79
26937141-8	2016	In contrast, PUFA docosahexaenoic acid (DHA) had the potential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation.	Fatty Acids, Unsaturated	13-17	NLR family, pyrin domain containing 3	Mus musculus	152-157
26937141-9	2016	Furthermore, a high-fat diet increased but PUFA-enriched diet decreased sensitization to LPS-induced hepatic NLRP3 inflammasome activation in vivo.	Fatty Acids, Unsaturated	43-47	NLR family, pyrin domain containing 3	Mus musculus	109-114
26657880-16	2016	This suggested the Rep protein of BFDV should be classified as an F-type ATPase and polyunsaturated fatty acid-sensitive GTPase.	Fatty Acids, Unsaturated	84-110	replication-associated protein	Beak and feather disease virus	19-22
26597785-3	2016	Our aim was to characterize the competition for accessing FADS2 mediated Delta6 desaturation between 16:0 and the most abundant polyunsaturated fatty acids (PUFA) in the human diet, 18:2n-6 and 18:3n-3, to evaluate whether competition may be relevant in other tissues and thus linked to metabolic abnormalities associated with FADS2 or fatty acid levels.	Fatty Acids, Unsaturated	128-155	fatty acid desaturase 2	Homo sapiens	58-63
26597785-3	2016	Our aim was to characterize the competition for accessing FADS2 mediated Delta6 desaturation between 16:0 and the most abundant polyunsaturated fatty acids (PUFA) in the human diet, 18:2n-6 and 18:3n-3, to evaluate whether competition may be relevant in other tissues and thus linked to metabolic abnormalities associated with FADS2 or fatty acid levels.	Fatty Acids, Unsaturated	157-161	fatty acid desaturase 2	Homo sapiens	58-63
26597785-3	2016	Our aim was to characterize the competition for accessing FADS2 mediated Delta6 desaturation between 16:0 and the most abundant polyunsaturated fatty acids (PUFA) in the human diet, 18:2n-6 and 18:3n-3, to evaluate whether competition may be relevant in other tissues and thus linked to metabolic abnormalities associated with FADS2 or fatty acid levels.	Fatty Acids, Unsaturated	157-161	fatty acid desaturase 2	Homo sapiens	327-332
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Fatty Acids, Unsaturated	0-27	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	75-80
26878780-0	2016	Short-term consumption of n-3 PUFAs increases murine IL-5 levels, but IL-5 is not the mechanistic link between n-3 fatty acids and changes in B-cell populations.	Fatty Acids, Unsaturated	30-35	interleukin 5	Mus musculus	53-57
26501394-0	2016	Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men.	Fatty Acids, Unsaturated	60-87	fatty acid desaturase 1	Homo sapiens	34-39
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Fatty Acids, Unsaturated	0-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Fatty Acids, Unsaturated	29-33	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	75-80
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Fatty Acids, Unsaturated	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Fatty Acids, Unsaturated	289-293	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	75-80
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Fatty Acids, Unsaturated	289-293	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26808997-9	2016	Many other differentially expressed genes were associated with metabolic pathways (including "Fatty acid metabolism", "Alanine, aspartate, and glutamate metabolism", and "Biosynthesis of unsaturated fatty acids") and cell signaling pathways (including "PPAR signaling pathway", "Adipocytokine signaling pathway", "TGF-beta signaling pathway", "MAPK signaling pathway", and "p53 signaling pathway").	Fatty Acids, Unsaturated	187-210	peroxisome proliferator activated receptor alpha	Gallus gallus	253-257
26666454-5	2016	Fatty acid composition of triacylglycerols synthesized by MtDGAT1 was compared to that of DGAT1 enzymes from Arabidopsis and Echium, with the results suggesting a substrate preference for monounsaturated over polyunsaturated fatty acids.	Fatty Acids, Unsaturated	209-236	membrane bound O-acyl transferase (MBOAT) family protein	Arabidopsis thaliana	60-65
26476938-4	2015	Overexpression or downregulation of miR-24 in goat mammary epithelial cells (GMEC) strongly affected fatty acid profiles; in particular, miR-24 enhanced unsaturated fatty acid concentration.	Fatty Acids, Unsaturated	153-175	microRNA 24	Capra hircus	36-42
26913550-1	2016	Fatty acid binding protein 4 (FABP4) I74 V, a gene polymorphism associated with unsaturated fatty acid contents, was discovered in Japanese Black cattle.	Fatty Acids, Unsaturated	80-102	fatty acid-binding protein, adipocyte	Bos taurus	0-28
26913550-1	2016	Fatty acid binding protein 4 (FABP4) I74 V, a gene polymorphism associated with unsaturated fatty acid contents, was discovered in Japanese Black cattle.	Fatty Acids, Unsaturated	80-102	fatty acid-binding protein, adipocyte	Bos taurus	30-35
27088787-1	2016	States associated with insulin resistance, as overweight/obesity, type 2 diabetes mellitus (DM2), cardiovascular diseases (CVD), some cancers and neuropsychiatric diseases are characterized with a decrease of long-chain polyunsaturated fatty acids (LC-PUFA) levels.	Fatty Acids, Unsaturated	220-247	pumilio RNA binding family member 3	Homo sapiens	252-256
26728928-0	2016	The Associations of C-Reactive Protein with Serum Levels of Polyunsaturated Fatty Acids and Trans Fatty Acids Among Middle-Aged Men from Three Populations.	Fatty Acids, Unsaturated	60-87	C-reactive protein	Homo sapiens	20-38
27818678-4	2016	The data highlights the central role of PPARG in milk fatty acid metabolism via controlling fatty acid elongation, biosynthesis of unsaturated fatty acid, lipid formation, and lipid secretion; furthermore, its role related to carbohydrate metabolism promotes the production of intermediates required for milk fat synthesis.	Fatty Acids, Unsaturated	131-153	peroxisome proliferator-activated receptor gamma	Capra hircus	40-45
26143741-1	2016	OBJECTIVE: To investigate whether a supplement of 2.2g of marine n-3 polyunsaturated fatty acids (PUFA) influences plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels in pre- and postmenopausal women.	Fatty Acids, Unsaturated	98-102	proprotein convertase subtilisin/kexin type 9	Homo sapiens	122-167
26143741-1	2016	OBJECTIVE: To investigate whether a supplement of 2.2g of marine n-3 polyunsaturated fatty acids (PUFA) influences plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels in pre- and postmenopausal women.	Fatty Acids, Unsaturated	98-102	proprotein convertase subtilisin/kexin type 9	Homo sapiens	169-174
26633493-0	2015	Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort).	Fatty Acids, Unsaturated	107-133	muscle associated receptor tyrosine kinase	Homo sapiens	39-43
26637528-5	2015	Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15.	Fatty Acids, Unsaturated	81-104	BHLH domain-containing protein	Caenorhabditis elegans	136-141
26637528-5	2015	Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15.	Fatty Acids, Unsaturated	81-104	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	146-152
26637528-5	2015	Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15.	Fatty Acids, Unsaturated	106-110	BHLH domain-containing protein	Caenorhabditis elegans	136-141
26637528-5	2015	Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15.	Fatty Acids, Unsaturated	106-110	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	146-152
26427404-2	2016	The encoded enzyme, ELOVL4, is required for the synthesis of very long chain polyunsaturated fatty acids (VLC-PUFAs), a rare class of &gt; C24 lipids.	Fatty Acids, Unsaturated	77-104	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	20-26
27313878-5	2016	Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert a beneficial effect by shifting Th1/Th2 balance to a Th2 phenotype and increasing insulin sensitivity.	Fatty Acids, Unsaturated	45-50	negative elongation factor complex member C/D	Homo sapiens	94-97
27313878-5	2016	Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert a beneficial effect by shifting Th1/Th2 balance to a Th2 phenotype and increasing insulin sensitivity.	Fatty Acids, Unsaturated	45-50	insulin	Homo sapiens	144-151
26773776-8	2016	Overall, there was a difference (P &lt; .05) in serum PON1 activity between the CC and TT genotypes in women ingesting either above or below the median total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, omega 3 (n-3) and omega 6 (n-6; P &lt; .05).	Fatty Acids, Unsaturated	215-242	paraoxonase 1	Homo sapiens	54-58
26827953-6	2016	In addition to the high-affinity 1,25D hormone, low-affinity nutritional VDR ligands including curcumin, polyunsaturated fatty acids, and anthocyanidins initiate VDR signaling, whereas the longevity principles resveratrol and SIRT1 potentiate VDR signaling.	Fatty Acids, Unsaturated	105-132	vitamin D receptor	Homo sapiens	73-76
26827953-6	2016	In addition to the high-affinity 1,25D hormone, low-affinity nutritional VDR ligands including curcumin, polyunsaturated fatty acids, and anthocyanidins initiate VDR signaling, whereas the longevity principles resveratrol and SIRT1 potentiate VDR signaling.	Fatty Acids, Unsaturated	105-132	vitamin D receptor	Homo sapiens	162-165
26827953-6	2016	In addition to the high-affinity 1,25D hormone, low-affinity nutritional VDR ligands including curcumin, polyunsaturated fatty acids, and anthocyanidins initiate VDR signaling, whereas the longevity principles resveratrol and SIRT1 potentiate VDR signaling.	Fatty Acids, Unsaturated	105-132	vitamin D receptor	Homo sapiens	162-165
26684003-8	2015	Based on the changes in fatty acid levels observed in seeds and leaves, we hypothesize that aphids potentially induce interference in the fatty acid desaturation pathway, likely reducing FAD2 and FAD6 activity that leads to a reduction in polyunsaturated fatty acids.	Fatty Acids, Unsaturated	239-266	omega-6 fatty acid desaturase	Glycine max	187-191
26643045-4	2015	Results show that, the major TAG species that comprised APA-HMFAs were rich in ALA and palmitic acid, which contained 64.52% total unsaturated fatty acids (UFAs) and 97.05% PA at the sn-2 position.	Fatty Acids, Unsaturated	131-154	glutamyl aminopeptidase	Homo sapiens	56-59
26643045-4	2015	Results show that, the major TAG species that comprised APA-HMFAs were rich in ALA and palmitic acid, which contained 64.52% total unsaturated fatty acids (UFAs) and 97.05% PA at the sn-2 position.	Fatty Acids, Unsaturated	156-160	glutamyl aminopeptidase	Homo sapiens	56-59
26327595-4	2015	Polyunsaturated fatty acids of marine origin (n-3 PUFA) prevent induction of SREBP-1c by insulin thereby reducing plasma and hepatic triglycerides.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Rattus norvegicus	77-85
26476938-4	2015	Overexpression or downregulation of miR-24 in goat mammary epithelial cells (GMEC) strongly affected fatty acid profiles; in particular, miR-24 enhanced unsaturated fatty acid concentration.	Fatty Acids, Unsaturated	153-175	microRNA 24	Capra hircus	137-143
26332891-1	2015	Ingestion of a high-fat diet composed mainly of the saturated fatty acid, palmitic (PA), and the unsaturated fatty acid, oleic (OA), stimulates transcription in the brain of the opioid neuropeptide, enkephalin (ENK), which promotes intake of substances of abuse.	Fatty Acids, Unsaturated	97-119	pyroglutamylated RFamide peptide	Rattus norvegicus	185-197
26332891-1	2015	Ingestion of a high-fat diet composed mainly of the saturated fatty acid, palmitic (PA), and the unsaturated fatty acid, oleic (OA), stimulates transcription in the brain of the opioid neuropeptide, enkephalin (ENK), which promotes intake of substances of abuse.	Fatty Acids, Unsaturated	97-119	proenkephalin	Rattus norvegicus	199-209
26347035-1	2015	The objective of the study was to characterize the immune profile of dairy ewes fed flaxseed, rich in polyunsaturated fatty acids (PUFA), around parturition.	Fatty Acids, Unsaturated	102-129	PUFA	Ovis aries	131-135
26332891-1	2015	Ingestion of a high-fat diet composed mainly of the saturated fatty acid, palmitic (PA), and the unsaturated fatty acid, oleic (OA), stimulates transcription in the brain of the opioid neuropeptide, enkephalin (ENK), which promotes intake of substances of abuse.	Fatty Acids, Unsaturated	97-119	proenkephalin	Rattus norvegicus	211-214
26675329-2	2015	The hypothesis of this study was that diet with a low ratio of n-6/n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced MMP13 expression in inflammatory chondrocytes in vitro and in vivo.	Fatty Acids, Unsaturated	71-98	matrix metallopeptidase 13	Rattus norvegicus	134-139
26675329-2	2015	The hypothesis of this study was that diet with a low ratio of n-6/n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced MMP13 expression in inflammatory chondrocytes in vitro and in vivo.	Fatty Acids, Unsaturated	100-105	matrix metallopeptidase 13	Rattus norvegicus	134-139
26226572-2	2015	The activity of acyltransferase (lysophosphatidylcholine acyltransferase [LPCAT]) is required for addition of polyunsaturated fatty acids to the sn-2 position of PCs and is therefore required to maintain cell membrane structure and function.	Fatty Acids, Unsaturated	110-137	lysophosphatidylcholine acyltransferase 3	Mus musculus	33-72
26280128-10	2015	Thus, our data indicate that GPR120 and GPR40 play a critical role as mediators of the beneficial effects of dietary unsaturated fatty acids in the context of obesity-induced insulin resistance.	Fatty Acids, Unsaturated	117-140	free fatty acid receptor 4	Mus musculus	29-35
26280128-10	2015	Thus, our data indicate that GPR120 and GPR40 play a critical role as mediators of the beneficial effects of dietary unsaturated fatty acids in the context of obesity-induced insulin resistance.	Fatty Acids, Unsaturated	117-140	free fatty acid receptor 1	Mus musculus	40-45
26446033-7	2015	On the other hand, PUFA diet resulted in lower levels of fasting glucose, total cholesterol, total triglycerides, and apolipoprotein B (P &lt; 0.05, FDR &lt; 0.1) but did not affect PPARG2 mRNA expression in adipose tissue.	Fatty Acids, Unsaturated	19-23	apolipoprotein B	Homo sapiens	118-134
26446033-7	2015	On the other hand, PUFA diet resulted in lower levels of fasting glucose, total cholesterol, total triglycerides, and apolipoprotein B (P &lt; 0.05, FDR &lt; 0.1) but did not affect PPARG2 mRNA expression in adipose tissue.	Fatty Acids, Unsaturated	19-23	peroxisome proliferator activated receptor gamma	Homo sapiens	182-188
26226572-2	2015	The activity of acyltransferase (lysophosphatidylcholine acyltransferase [LPCAT]) is required for addition of polyunsaturated fatty acids to the sn-2 position of PCs and is therefore required to maintain cell membrane structure and function.	Fatty Acids, Unsaturated	110-137	lysophosphatidylcholine acyltransferase 3	Mus musculus	74-79
26439440-1	2015	Part I: maternal FADS2 genotype and DNA methylation correlate with polyunsaturated fatty acid status in toddlers: an exploratory analysis.	Fatty Acids, Unsaturated	67-93	fatty acid desaturase 2	Homo sapiens	17-22
25132099-2	2015	The aim of our study was to investigate the influence of Lys656Asn polymorphism in the leptin receptor gene on cardiovascular risk factors, weight loss, and serum leptin levels to a high polyunsaturated fatty acid (PUFA) hypocaloric diet in obese patients.	Fatty Acids, Unsaturated	187-213	leptin	Homo sapiens	87-93
25132099-2	2015	The aim of our study was to investigate the influence of Lys656Asn polymorphism in the leptin receptor gene on cardiovascular risk factors, weight loss, and serum leptin levels to a high polyunsaturated fatty acid (PUFA) hypocaloric diet in obese patients.	Fatty Acids, Unsaturated	187-213	leptin	Homo sapiens	163-169
25132099-2	2015	The aim of our study was to investigate the influence of Lys656Asn polymorphism in the leptin receptor gene on cardiovascular risk factors, weight loss, and serum leptin levels to a high polyunsaturated fatty acid (PUFA) hypocaloric diet in obese patients.	Fatty Acids, Unsaturated	215-219	leptin	Homo sapiens	87-93
25132099-2	2015	The aim of our study was to investigate the influence of Lys656Asn polymorphism in the leptin receptor gene on cardiovascular risk factors, weight loss, and serum leptin levels to a high polyunsaturated fatty acid (PUFA) hypocaloric diet in obese patients.	Fatty Acids, Unsaturated	215-219	leptin	Homo sapiens	163-169
26439440-10	2015	This exploratory study suggests that maternal FADS2 genetic and epigenetic status could be related to toddlers" polyunsaturated fatty acid metabolism.	Fatty Acids, Unsaturated	112-138	fatty acid desaturase 2	Homo sapiens	46-51
26519053-1	2015	BACKGROUND: Bovine milk fat composition is responsive to dietary manipulation providing an avenue to modify the content of fatty acids and especially some specific unsaturated fatty acid (USFA) isomers of benefit to human health.	Fatty Acids, Unsaturated	164-186	Weaning weight-maternal milk	Bos taurus	19-23
26456834-0	2015	Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of beta-Catenin.	Fatty Acids, Unsaturated	0-23	catenin beta 1	Homo sapiens	72-84
26456834-3	2015	Unsaturated FAs bind to the UAS domain of Fas-associated factor 1 (FAF1), a protein known to bind beta-catenin, accelerating its degradation.	Fatty Acids, Unsaturated	0-15	Fas associated factor 1	Homo sapiens	42-65
26456834-3	2015	Unsaturated FAs bind to the UAS domain of Fas-associated factor 1 (FAF1), a protein known to bind beta-catenin, accelerating its degradation.	Fatty Acids, Unsaturated	0-15	Fas associated factor 1	Homo sapiens	67-71
26456834-3	2015	Unsaturated FAs bind to the UAS domain of Fas-associated factor 1 (FAF1), a protein known to bind beta-catenin, accelerating its degradation.	Fatty Acids, Unsaturated	0-15	catenin beta 1	Homo sapiens	98-110
26456834-6	2015	In clear cell renal cell carcinoma (ccRCC) cells, unsaturated FAs stimulated cell proliferation through stabilization of beta-catenin.	Fatty Acids, Unsaturated	50-65	catenin beta 1	Homo sapiens	121-133
26456834-7	2015	In tissues from biopsies of human ccRCC, elevated levels of unsaturated FAs correlated with increased levels of beta-catenin.	Fatty Acids, Unsaturated	60-75	catenin beta 1	Homo sapiens	112-124
26452545-7	2015	Gene ontology (GO) enrichment and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis showed that the SDE genes were most enrichment in steroid biosynthesis, PPAR signaling pathway, biosynthesis of unsaturated fatty acids, glycerophospholipid metabolism, three amino acid pathways, and pyruvate metabolism (P &lt;= 0.05).	Fatty Acids, Unsaturated	210-233	peroxisome proliferator activated receptor alpha	Gallus gallus	170-174
26240151-3	2015	We hypothesized that n-6 PUFA like linoleic acid (LA) or other downstream PUFAs like gamma-linolenic acid or arachidonic acid alter the transforming growth factor-beta (TGFbeta)-collagen axis in the heart.	Fatty Acids, Unsaturated	74-79	transforming growth factor, beta 1	Mus musculus	169-176
26321664-1	2015	Fatty acid elongase 5 (ELOVL5) is an enzyme involved in the synthesis of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	73-100	ELOVL fatty acid elongase 5	Homo sapiens	23-29
26321664-2	2015	Sterol Regulatory Element-binding Protein (SREBP)-1 activates ELOVL5 and increases polyunsaturated fatty acid synthesis, which in turn negatively affects SREBP-1 expression.	Fatty Acids, Unsaturated	83-109	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	0-41
26321664-2	2015	Sterol Regulatory Element-binding Protein (SREBP)-1 activates ELOVL5 and increases polyunsaturated fatty acid synthesis, which in turn negatively affects SREBP-1 expression.	Fatty Acids, Unsaturated	83-109	sterol regulatory element binding transcription factor 1	Homo sapiens	43-51
26321664-2	2015	Sterol Regulatory Element-binding Protein (SREBP)-1 activates ELOVL5 and increases polyunsaturated fatty acid synthesis, which in turn negatively affects SREBP-1 expression.	Fatty Acids, Unsaturated	83-109	sterol regulatory element binding transcription factor 1	Homo sapiens	154-161
26386665-1	2015	Microsomal omega-6 fatty acid desaturase (FAD2-1B) is an enzyme that regulates the polyunsaturated fatty acid content in soybeans (Glycine max).	Fatty Acids, Unsaturated	83-109	omega-6 fatty acid desaturase	Glycine max	0-40
26386665-1	2015	Microsomal omega-6 fatty acid desaturase (FAD2-1B) is an enzyme that regulates the polyunsaturated fatty acid content in soybeans (Glycine max).	Fatty Acids, Unsaturated	83-109	omega-6 fatty acid desaturase	Glycine max	42-49
26193433-7	2015	In the native lipoproteins, HL showed specificity for PC species containing polyunsaturated fatty acids at sn-2 position, and produced more unsaturated lyso PC species.	Fatty Acids, Unsaturated	76-103	lipase C, hepatic type	Homo sapiens	28-30
26401073-14	2015	Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1a and PC.	Fatty Acids, Unsaturated	103-129	GRDX	Homo sapiens	146-149
26240151-6	2015	Overexpression of fatty acid desaturase 2 (fads2), which metabolizes LA to downstream PUFAs, reduced collagen deposits, LOX maturation, and activity with LA, whereas overexpressing fads1, unrelated to LA desaturation, did not.	Fatty Acids, Unsaturated	86-91	fatty acid desaturase 2	Mus musculus	18-41
26240151-6	2015	Overexpression of fatty acid desaturase 2 (fads2), which metabolizes LA to downstream PUFAs, reduced collagen deposits, LOX maturation, and activity with LA, whereas overexpressing fads1, unrelated to LA desaturation, did not.	Fatty Acids, Unsaturated	86-91	fatty acid desaturase 2	Mus musculus	43-48
26233865-7	2015	VEGF, an angiogenic factor, is necessary for the transport of polyunsaturated fatty acids (PUFAs) to endothelial cells.	Fatty Acids, Unsaturated	62-89	vascular endothelial growth factor A	Homo sapiens	0-4
26374175-1	2015	Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA effects in the body.	Fatty Acids, Unsaturated	22-49	pumilio RNA binding family member 3	Homo sapiens	51-55
26233865-7	2015	VEGF, an angiogenic factor, is necessary for the transport of polyunsaturated fatty acids (PUFAs) to endothelial cells.	Fatty Acids, Unsaturated	91-96	vascular endothelial growth factor A	Homo sapiens	0-4
26233865-12	2015	PUFAs also augment the production of NO and inhibit the activity of angiotensin-converting enzyme and antagonize the actions of angiotensin II.	Fatty Acids, Unsaturated	0-5	angiotensinogen	Homo sapiens	128-142
26233865-13	2015	Thus, PUFAs can prevent activation of angiotensin II receptor type 1 a (AT1 receptor).	Fatty Acids, Unsaturated	6-11	angiotensinogen	Homo sapiens	38-52
26262701-9	2015	A lower consumption of fat, especially of polyunsaturated fatty acids, was observed in the patients that achieved the nutritional recommendations and in the super-obese patients.	Fatty Acids, Unsaturated	42-69	FAT atypical cadherin 1	Homo sapiens	23-26
26327761-5	2015	Unsaturated fatty acids at high concentrations but not saturated fatty acids induced intra-acinar cell trypsin activation and cell damage and increased PKC expression.	Fatty Acids, Unsaturated	0-23	proline rich transmembrane protein 2	Homo sapiens	152-155
26327761-7	2015	Unsaturated fatty acids may play a distinctive role in the pathogenesis of pancreatitis through the activation of PKC family members.	Fatty Acids, Unsaturated	0-23	proline rich transmembrane protein 2	Homo sapiens	114-117
26098646-3	2015	Conversely, unsaturated fatty acids like oleate (OL) promote non-canonical, PIK3C3- and BECN1-independent autophagy.	Fatty Acids, Unsaturated	12-35	phosphatidylinositol 3-kinase catalytic subunit type 3	Mus musculus	76-82
26098646-3	2015	Conversely, unsaturated fatty acids like oleate (OL) promote non-canonical, PIK3C3- and BECN1-independent autophagy.	Fatty Acids, Unsaturated	12-35	beclin 1, autophagy related	Mus musculus	88-93
25754996-3	2015	The key enzymes fatty acid desaturase (FAD) and diacylglycerol acyltransferase (DGAT) are responsible for UFA biosynthesis (a push process) and assembling fatty acids into lipids (a pull process) in plants, respectively.	Fatty Acids, Unsaturated	106-109	diacylglycerol acyltransferase	Arabidopsis thaliana	48-78
25754996-3	2015	The key enzymes fatty acid desaturase (FAD) and diacylglycerol acyltransferase (DGAT) are responsible for UFA biosynthesis (a push process) and assembling fatty acids into lipids (a pull process) in plants, respectively.	Fatty Acids, Unsaturated	106-109	diacylglycerol acyltransferase	Arabidopsis thaliana	80-84
26237540-0	2015	Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3alpha.	Fatty Acids, Unsaturated	0-23	hypoxia inducible factor 3 subunit alpha	Homo sapiens	96-127
26237540-3	2015	Here we report novel evidence showing that unsaturated fatty acids are naturally occurring, non-covalent structural ligands of HIF-3alpha, thus providing the initial framework for exploring its exceptional role as a lipid sensor under hypoxia.	Fatty Acids, Unsaturated	43-66	hypoxia inducible factor 3 subunit alpha	Homo sapiens	127-137
25911511-13	2015	PUFA metabolites extracted from IBS biopsies or colons of mice with visceral hypersensitivity activated mouse sensory neurons in vitro, by activating TRPV4.	Fatty Acids, Unsaturated	0-4	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	150-155
26596040-8	2015	The biological role of leptin is in preventing a) deposition of surplus amount of non-polar triglycerides in fatty cells; b) formation of endoplasmic "stress"; c) death of fatty cells in apoptosis way, formation of corpuscles of apoptosis and failure of biological function of endoecology; d) formation of biological reaction of inflammation in visceral fatty tissue; e) high level of unsaturated fatty acids in intercellular medium and f) development of metabolic syndrome.	Fatty Acids, Unsaturated	385-408	leptin	Homo sapiens	23-29
26177196-9	2015	In addition, the expression of peroxisome proliferator activated receptor gamma (PPAR-gamma), transforming growth factor beta (TGF-beta) and interleukin (IL)-10 were significantly up-regulated in n-3 PUFA-enriched diet-fed mice.	Fatty Acids, Unsaturated	200-204	peroxisome proliferator activated receptor gamma	Mus musculus	31-79
26177196-9	2015	In addition, the expression of peroxisome proliferator activated receptor gamma (PPAR-gamma), transforming growth factor beta (TGF-beta) and interleukin (IL)-10 were significantly up-regulated in n-3 PUFA-enriched diet-fed mice.	Fatty Acids, Unsaturated	200-204	peroxisome proliferator activated receptor gamma	Mus musculus	81-91
26177196-9	2015	In addition, the expression of peroxisome proliferator activated receptor gamma (PPAR-gamma), transforming growth factor beta (TGF-beta) and interleukin (IL)-10 were significantly up-regulated in n-3 PUFA-enriched diet-fed mice.	Fatty Acids, Unsaturated	200-204	transforming growth factor, beta 1	Mus musculus	127-135
26177196-9	2015	In addition, the expression of peroxisome proliferator activated receptor gamma (PPAR-gamma), transforming growth factor beta (TGF-beta) and interleukin (IL)-10 were significantly up-regulated in n-3 PUFA-enriched diet-fed mice.	Fatty Acids, Unsaturated	200-204	interleukin 10	Mus musculus	141-160
25881896-3	2015	However, the role of polyunsaturated fatty acids in Abeta metabolism remains unknown.	Fatty Acids, Unsaturated	21-48	amyloid beta (A4) precursor protein	Mus musculus	52-57
26109183-6	2015	There were interactions between n-3 PUFA consumption and E2 injection on hepatic expression of FAS and DGAT2.	Fatty Acids, Unsaturated	36-40	fatty acid synthase	Rattus norvegicus	95-98
26109183-6	2015	There were interactions between n-3 PUFA consumption and E2 injection on hepatic expression of FAS and DGAT2.	Fatty Acids, Unsaturated	36-40	diacylglycerol O-acyltransferase 2	Rattus norvegicus	103-108
25838428-7	2015	Subsequently, pharmacological LXR agonist increased long chain PUFA synthesis and enhanced arachidonic acid content in the phospholipids of human macrophages.	Fatty Acids, Unsaturated	63-67	nuclear receptor subfamily 1, group H, member 3	Mus musculus	30-33
25959085-10	2015	The levels of other FAs, including polyunsaturated FAs, were also changed in SCD1-inhibited adipocytes.	Fatty Acids, Unsaturated	35-54	stearoyl-Coenzyme A desaturase 1	Mus musculus	77-81
26123542-7	2015	Complementation studies with the A. thaliana rod1 mutant demonstrated that the flax PDCTs were capable of restoring PUFA levels in planta.	Fatty Acids, Unsaturated	116-120	phosphatidic acid phosphatase-related / PAP2-like protein	Arabidopsis thaliana	45-49
26110756-2	2015	These products often contain milk fat and/or vegetable oils, and are supplemented or not supplemented with oils rich in long chain polyunsaturated fatty acids (LC-PUFA).	Fatty Acids, Unsaturated	131-158	pumilio RNA binding family member 3	Homo sapiens	163-167
25899092-1	2015	We aimed to investigate whether dietary intake of total or individual (n-3, n-6, and n-3:n-6 ratio) polyunsaturated fatty acids (PUFAs) was prospectively associated with serum levels of C-reactive protein (CRP), a marker of inflammation.	Fatty Acids, Unsaturated	100-127	C-reactive protein	Homo sapiens	186-204
25899092-1	2015	We aimed to investigate whether dietary intake of total or individual (n-3, n-6, and n-3:n-6 ratio) polyunsaturated fatty acids (PUFAs) was prospectively associated with serum levels of C-reactive protein (CRP), a marker of inflammation.	Fatty Acids, Unsaturated	100-127	C-reactive protein	Homo sapiens	206-209
26074075-5	2015	Dbc1 deficiency promoted SirT1-dependent gain of function of stearoyl-coenzyme A desaturase 1 (Scd1), increasing plasma and tissue levels of unsaturated fatty acids.	Fatty Acids, Unsaturated	141-164	cell cycle activator and apoptosis regulator 2	Mus musculus	0-4
25691235-6	2015	Milk fatty acid composition was associated primarily with estrous-cycle day: polyunsaturated fatty acids increased by 16%, n-6 by 15% and n-3 by 1% from day 1 to 8 post-estrus.	Fatty Acids, Unsaturated	77-104	Weaning weight-maternal milk	Bos taurus	0-4
25838428-11	2015	Moreover, we demonstrate here that LXR agonist treatment modulates PUFA metabolism in atherosclerotic arteries.	Fatty Acids, Unsaturated	67-71	nuclear receptor subfamily 1, group H, member 3	Mus musculus	35-38
25824843-10	2015	Lipidomic analyses of released NEFAs from lipoproteins demonstrate that sPLA2s with anti-Plasmodium properties are those that release polyunsaturated fatty acids (PUFAs), with hGIIF being the most selective enzyme.	Fatty Acids, Unsaturated	134-161	phospholipase A2 group IID	Homo sapiens	72-78
25824843-10	2015	Lipidomic analyses of released NEFAs from lipoproteins demonstrate that sPLA2s with anti-Plasmodium properties are those that release polyunsaturated fatty acids (PUFAs), with hGIIF being the most selective enzyme.	Fatty Acids, Unsaturated	163-168	phospholipase A2 group IID	Homo sapiens	72-78
26466444-12	2015	The absorption of poly-unsaturated fatty acids by cells with apoB-100 = endocytosis form sensitivity of animals to exogenous hyper spirit cholesterol and absorption of poly-unsaturated fatty acids by apoE/A-I = receptors form corresponding resistance.	Fatty Acids, Unsaturated	18-46	apolipoprotein B	Homo sapiens	61-69
26466444-12	2015	The absorption of poly-unsaturated fatty acids by cells with apoB-100 = endocytosis form sensitivity of animals to exogenous hyper spirit cholesterol and absorption of poly-unsaturated fatty acids by apoE/A-I = receptors form corresponding resistance.	Fatty Acids, Unsaturated	18-46	apolipoprotein E	Homo sapiens	200-204
26466444-12	2015	The absorption of poly-unsaturated fatty acids by cells with apoB-100 = endocytosis form sensitivity of animals to exogenous hyper spirit cholesterol and absorption of poly-unsaturated fatty acids by apoE/A-I = receptors form corresponding resistance.	Fatty Acids, Unsaturated	168-196	apolipoprotein B	Homo sapiens	61-69
26466444-12	2015	The absorption of poly-unsaturated fatty acids by cells with apoB-100 = endocytosis form sensitivity of animals to exogenous hyper spirit cholesterol and absorption of poly-unsaturated fatty acids by apoE/A-I = receptors form corresponding resistance.	Fatty Acids, Unsaturated	168-196	apolipoprotein E	Homo sapiens	200-204
25497832-0	2015	Three unsaturated fatty acid biosynthesis-related genes in yellow catfish Pelteobagrus fulvidraco: Molecular characterization, tissue expression and transcriptional regulation by leptin.	Fatty Acids, Unsaturated	6-28	leptin	Homo sapiens	179-185
25968567-7	2015	Instead, lipidomic analysis of malignancy-associated ascites revealed high concentrations of polyunsaturated fatty acids, in particular linoleic acid, acting as potent PPARbeta/delta agonists in macrophages.	Fatty Acids, Unsaturated	93-120	peroxisome proliferator activated receptor delta	Homo sapiens	168-176
25603423-3	2015	In addition, many tumors over-express cyclooxygenase, lipoxygenase or cytochrome P450 enzymes that mediate the biotransformation of omega-6 polyunsaturated fatty acids (PUFAs) to potent eicosanoid regulators of tumor cell proliferation and cell death.	Fatty Acids, Unsaturated	169-174	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-85
25816805-2	2015	n-3 polyunsaturated fatty acids (PUFA) from seafood have several beneficial effects in patients with endstage renal disease (ESRD) and the aim of the present study was to assess the effect of n-3 PUFA supplementation on plasma adiponectin levels in ESRD patients.	Fatty Acids, Unsaturated	33-37	adiponectin, C1Q and collagen domain containing	Homo sapiens	227-238
26925376-2	2015	The aim of this study was to assess the influence of a low calorie diet with or without n-3 PUFA supplementation on glucose dependent insulinotropic polypeptide (GIP) output and insulin sensitivity markers in obese subjects.	Fatty Acids, Unsaturated	92-96	gastric inhibitory polypeptide	Homo sapiens	116-160
26925376-2	2015	The aim of this study was to assess the influence of a low calorie diet with or without n-3 PUFA supplementation on glucose dependent insulinotropic polypeptide (GIP) output and insulin sensitivity markers in obese subjects.	Fatty Acids, Unsaturated	92-96	insulin	Homo sapiens	134-141
25936805-5	2015	Our mass spectrometry analysis has independently identified DEPTOR as an mTOR binding partner dissociated by PA. Interestingly, only PA species with unsaturated fatty acid chains, such as those produced by PLD, are capable of displacing DEPTOR and activating mTORC1, with high affinity for the FRB domain of mTOR.	Fatty Acids, Unsaturated	149-171	DEP domain containing MTOR interacting protein	Homo sapiens	60-66
25936805-5	2015	Our mass spectrometry analysis has independently identified DEPTOR as an mTOR binding partner dissociated by PA. Interestingly, only PA species with unsaturated fatty acid chains, such as those produced by PLD, are capable of displacing DEPTOR and activating mTORC1, with high affinity for the FRB domain of mTOR.	Fatty Acids, Unsaturated	149-171	mechanistic target of rapamycin kinase	Homo sapiens	73-77
25936805-5	2015	Our mass spectrometry analysis has independently identified DEPTOR as an mTOR binding partner dissociated by PA. Interestingly, only PA species with unsaturated fatty acid chains, such as those produced by PLD, are capable of displacing DEPTOR and activating mTORC1, with high affinity for the FRB domain of mTOR.	Fatty Acids, Unsaturated	149-171	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	206-209
25936805-5	2015	Our mass spectrometry analysis has independently identified DEPTOR as an mTOR binding partner dissociated by PA. Interestingly, only PA species with unsaturated fatty acid chains, such as those produced by PLD, are capable of displacing DEPTOR and activating mTORC1, with high affinity for the FRB domain of mTOR.	Fatty Acids, Unsaturated	149-171	DEP domain containing MTOR interacting protein	Homo sapiens	237-243
25936805-5	2015	Our mass spectrometry analysis has independently identified DEPTOR as an mTOR binding partner dissociated by PA. Interestingly, only PA species with unsaturated fatty acid chains, such as those produced by PLD, are capable of displacing DEPTOR and activating mTORC1, with high affinity for the FRB domain of mTOR.	Fatty Acids, Unsaturated	149-171	CREB regulated transcription coactivator 1	Mus musculus	259-265
25936805-5	2015	Our mass spectrometry analysis has independently identified DEPTOR as an mTOR binding partner dissociated by PA. Interestingly, only PA species with unsaturated fatty acid chains, such as those produced by PLD, are capable of displacing DEPTOR and activating mTORC1, with high affinity for the FRB domain of mTOR.	Fatty Acids, Unsaturated	149-171	mechanistic target of rapamycin kinase	Homo sapiens	259-263
25893499-2	2015	PLA2 enzymes are key players in inflammation regulating the release of unsaturated fatty acids such as arachidonic acid (AA), a precursor of pro-inflammatory eicosanoids.	Fatty Acids, Unsaturated	71-94	phospholipase A2 group VI	Homo sapiens	0-4
25529698-1	2015	Lipoxygenase (LOX)-catalysed degradation of polyunsaturated fatty acids is supposed to be a major cause of undesirable off-flavour development in legumes.	Fatty Acids, Unsaturated	44-71	linoleate 9S-lipoxygenase-4	Glycine max	0-12
25529698-1	2015	Lipoxygenase (LOX)-catalysed degradation of polyunsaturated fatty acids is supposed to be a major cause of undesirable off-flavour development in legumes.	Fatty Acids, Unsaturated	44-71	linoleate 9S-lipoxygenase-4	Glycine max	14-17
25995742-0	2015	Polyunsaturated fatty acids augment tumoricidal action of 5-fluorouracil on gastric cancer cells by their action on vascular endothelial growth factor, tumor necrosis factor-alpha and lipid metabolism related factors.	Fatty Acids, Unsaturated	0-27	vascular endothelial growth factor A	Homo sapiens	116-150
25995742-0	2015	Polyunsaturated fatty acids augment tumoricidal action of 5-fluorouracil on gastric cancer cells by their action on vascular endothelial growth factor, tumor necrosis factor-alpha and lipid metabolism related factors.	Fatty Acids, Unsaturated	0-27	tumor necrosis factor	Homo sapiens	152-179
25580849-5	2015	Pre-incubation of cells with isotope-reinforced polyunsaturated fatty acids (D-PUFAs) completely prevented the effect of oligomeric alpha-Syn on lipid peroxidation.	Fatty Acids, Unsaturated	48-75	synuclein alpha	Homo sapiens	132-141
25580849-9	2015	Specific inhibition of lipid peroxidation by incubation with reinforced polyunsaturated fatty acids (D-PUFAs) completely prevented the effect of alpha-synuclein on lipid peroxidation and cell death.	Fatty Acids, Unsaturated	72-99	synuclein alpha	Homo sapiens	145-160
25218301-1	2015	The synthesis of oxygenated eicosanoids is the result of the coordinated action of several enzymatic activities, from phospholipase A2 that releases the polyunsaturated fatty acids from membrane phospholipids, to primary oxidative enzymes, such as cyclooxygenases and lipoxygenases, to isomerases, synthases and hydrolases that carry out the final synthesis of the biologically active metabolites.	Fatty Acids, Unsaturated	153-180	phospholipase A2 group IB	Homo sapiens	118-134
25845931-5	2015	omega3 PUFAs endogenously generated in fat-1 mice (n=9), but not in compound Ffar4(-/-)/fat-1 mice (n=9), attenuated femoral arterial thrombosis induced by FeCl3.	Fatty Acids, Unsaturated	7-12	FAT atypical cadherin 1	Mus musculus	39-44
25512019-7	2015	MMP-9 immunoreactive stain intensity was lower in mice fed the high, compared to the low n-3 PUFA diet in endothelial cells (suprarenal aorta), and inflammatory cells (suprarenal and infrarenal aorta).	Fatty Acids, Unsaturated	93-97	matrix metallopeptidase 9	Mus musculus	0-5
25688091-2	2015	Tafazzin is a transacylase that transfers acyl chains with unsaturated fatty acids from phospholipids to monolysocardiolipin to generate cardiolipin with unsaturated fatty acids.	Fatty Acids, Unsaturated	59-82	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	0-8
25688091-2	2015	Tafazzin is a transacylase that transfers acyl chains with unsaturated fatty acids from phospholipids to monolysocardiolipin to generate cardiolipin with unsaturated fatty acids.	Fatty Acids, Unsaturated	154-177	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	0-8
25325736-4	2015	Calcium imaging of primary L cells and the model cell line GLUTag revealed responses triggered by the TRPA1 agonists allyl-isothiocyanate (mustard oil), carvacrol, and polyunsaturated fatty acids, which were blocked by TRPA1 antagonists.	Fatty Acids, Unsaturated	168-195	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	102-107
25325736-4	2015	Calcium imaging of primary L cells and the model cell line GLUTag revealed responses triggered by the TRPA1 agonists allyl-isothiocyanate (mustard oil), carvacrol, and polyunsaturated fatty acids, which were blocked by TRPA1 antagonists.	Fatty Acids, Unsaturated	168-195	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	219-224
25482287-3	2015	The aim of the present study was to investigate the effects of the deletion of PARP-1 expression on polyunsaturated fatty acids (PUFA), and PUFA metabolite composition, in mice under control conditions or undergoing an oxazolone (OXA)-induced contact hypersensitivity reaction (CHS).	Fatty Acids, Unsaturated	100-127	poly (ADP-ribose) polymerase family, member 1	Mus musculus	79-85
25592082-8	2015	The expression levels of PPARG, SPEBF1, CSN1S1, and CSN3 mRNA in the BMECs were affected significantly after adding different ratios of UFAs.	Fatty Acids, Unsaturated	136-140	peroxisome proliferator activated receptor gamma	Bos taurus	25-30
25592082-8	2015	The expression levels of PPARG, SPEBF1, CSN1S1, and CSN3 mRNA in the BMECs were affected significantly after adding different ratios of UFAs.	Fatty Acids, Unsaturated	136-140	casein alpha s1	Bos taurus	40-46
25592082-8	2015	The expression levels of PPARG, SPEBF1, CSN1S1, and CSN3 mRNA in the BMECs were affected significantly after adding different ratios of UFAs.	Fatty Acids, Unsaturated	136-140	casein kappa	Bos taurus	52-56
25534488-1	2015	To explore the effect and mechanism of action of different omega-6/omega-3 polyunsaturated fatty acids (PUFAs) ratio on the expression of AKT and mTOR in mice bearing endometrial carcinoma.	Fatty Acids, Unsaturated	104-109	thymoma viral proto-oncogene 1	Mus musculus	138-141
25534488-1	2015	To explore the effect and mechanism of action of different omega-6/omega-3 polyunsaturated fatty acids (PUFAs) ratio on the expression of AKT and mTOR in mice bearing endometrial carcinoma.	Fatty Acids, Unsaturated	104-109	mechanistic target of rapamycin kinase	Mus musculus	146-150
25482287-3	2015	The aim of the present study was to investigate the effects of the deletion of PARP-1 expression on polyunsaturated fatty acids (PUFA), and PUFA metabolite composition, in mice under control conditions or undergoing an oxazolone (OXA)-induced contact hypersensitivity reaction (CHS).	Fatty Acids, Unsaturated	129-133	poly (ADP-ribose) polymerase family, member 1	Mus musculus	79-85
25482287-9	2015	The results of the present study suggest that the genetic deletion of PARP-1 may affect the PUFA-homeostasis of the skin, resulting in an anti-inflammatory milieu, including increased DHA and EPA levels, and DHA and EPA metabolite levels.	Fatty Acids, Unsaturated	92-96	poly (ADP-ribose) polymerase family, member 1	Mus musculus	70-76
25755223-0	2015	Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function.	Fatty Acids, Unsaturated	0-26	fatty acid desaturase 1	Homo sapiens	51-56
25755223-0	2015	Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function.	Fatty Acids, Unsaturated	0-26	fatty acid desaturase 2	Homo sapiens	61-66
25755223-1	2015	OBJECTIVE: Polyunsaturated fatty acids (PUFAs) regulate fatty acid desaturase (FADS1, FADS2) expression in the liver; however, it is unknown whether PUFAs regulate FADS in adipocytes.	Fatty Acids, Unsaturated	11-38	fatty acid desaturase 1	Homo sapiens	79-84
25755223-1	2015	OBJECTIVE: Polyunsaturated fatty acids (PUFAs) regulate fatty acid desaturase (FADS1, FADS2) expression in the liver; however, it is unknown whether PUFAs regulate FADS in adipocytes.	Fatty Acids, Unsaturated	11-38	fatty acid desaturase 2	Homo sapiens	86-91
25755223-1	2015	OBJECTIVE: Polyunsaturated fatty acids (PUFAs) regulate fatty acid desaturase (FADS1, FADS2) expression in the liver; however, it is unknown whether PUFAs regulate FADS in adipocytes.	Fatty Acids, Unsaturated	40-45	fatty acid desaturase 1	Homo sapiens	79-84
25755223-1	2015	OBJECTIVE: Polyunsaturated fatty acids (PUFAs) regulate fatty acid desaturase (FADS1, FADS2) expression in the liver; however, it is unknown whether PUFAs regulate FADS in adipocytes.	Fatty Acids, Unsaturated	40-45	fatty acid desaturase 2	Homo sapiens	86-91
25653282-6	2015	Collectively, our findings indicate that increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression and function by promoting its degradation via the ubiquitin-proteasome system.	Fatty Acids, Unsaturated	67-90	solute carrier family 38 member 2	Homo sapiens	149-154
25366546-4	2015	RESULTS: The levels of unsaturated fatty acid moieties of PS80 were negatively correlated to RCP of [(18)F]Flutemetamol after synthesis.	Fatty Acids, Unsaturated	23-45	CGRP receptor component	Homo sapiens	93-96
25366546-8	2015	CONCLUSIONS: The presence of unsaturated fatty acid moieties in PS80 was found to be one of the most important factors responsible for the reduction in RCP of [(18)F]Flutemetamol after synthesis.	Fatty Acids, Unsaturated	29-51	CGRP receptor component	Homo sapiens	152-155
25825911-2	2015	SAD catalyzes desaturation of stearoyl-ACP to oleyl-ACP and plays a key role in determining the homeostasis between saturated fatty acids and unsaturated fatty acids, which is an important player in cold acclimation in plants.	Fatty Acids, Unsaturated	142-165	stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic	Solanum tuberosum	0-3
25653282-0	2015	Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability.	Fatty Acids, Unsaturated	77-99	solute carrier family 38 member 2	Homo sapiens	35-40
25653282-0	2015	Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability.	Fatty Acids, Unsaturated	77-99	solute carrier family 38 member 2	Homo sapiens	42-49
25881314-0	2015	Differential regulation of protein expression in response to polyunsaturated fatty acids in the liver of apoE-knockout mice and in HepG2 cells.	Fatty Acids, Unsaturated	61-88	apolipoprotein E	Mus musculus	105-109
25888880-9	2015	Thus, the present study indicates that activation of PPARalpha induced either by native agonists such as dietary polyunsaturated fatty acids or a by negative energy balance might be largely uncritical in lactating sows with respect to milk production and litter gains in lactating sows.	Fatty Acids, Unsaturated	113-140	peroxisome proliferator activated receptor alpha	Rattus norvegicus	53-62
25201247-6	2015	UFAs dose-dependently inhibited the increase in IL-1beta secretion and decrease in IL-1Ra secretion induced by Pal.	Fatty Acids, Unsaturated	0-4	interleukin 1 beta	Homo sapiens	48-56
25201247-6	2015	UFAs dose-dependently inhibited the increase in IL-1beta secretion and decrease in IL-1Ra secretion induced by Pal.	Fatty Acids, Unsaturated	0-4	interleukin 1 receptor antagonist	Homo sapiens	83-89
25579844-7	2015	Lipase inhibition reduced fat necrosis, UFAs, organ failure, and mortality but not the parameters of AP induction.	Fatty Acids, Unsaturated	40-44	lipase, endothelial	Mus musculus	0-6
25500141-9	2015	Our combined data show that upregulation of ACSL4 is responsible for the increase in PUFA-TAG species during activation of HSCs, which may serve to protect cells against a shortage of PUFAs required for eicosanoid secretion.	Fatty Acids, Unsaturated	184-189	acyl-CoA synthetase long chain family member 4	Homo sapiens	44-49
25500141-9	2015	Our combined data show that upregulation of ACSL4 is responsible for the increase in PUFA-TAG species during activation of HSCs, which may serve to protect cells against a shortage of PUFAs required for eicosanoid secretion.	Fatty Acids, Unsaturated	184-189	pumilio RNA binding family member 3	Homo sapiens	85-89
25449400-7	2015	N-3 polyunsaturated fatty acids (PUFAs) or sertraline administration reversed the changes in behavioral test and induced the expression of tPA in certain brain areas, but failed to restore the CUMS-induced PAI-1 expression.	Fatty Acids, Unsaturated	33-38	plasminogen activator, tissue type	Rattus norvegicus	139-142
25646338-6	2015	RESULTS: Among European-ancestry participants, 31 SNPs in or near the fatty acid desaturase (FADS) 1 and 2 cluster were associated with cis/trans-18:2; a top hit was rs174548 (beta = 0.0035, P = 4.90 x 10(-15)), an SNP previously associated with circulating n-3 and n-6 polyunsaturated fatty acid concentrations.	Fatty Acids, Unsaturated	270-296	stearoyl-CoA desaturase	Homo sapiens	70-91
25646338-6	2015	RESULTS: Among European-ancestry participants, 31 SNPs in or near the fatty acid desaturase (FADS) 1 and 2 cluster were associated with cis/trans-18:2; a top hit was rs174548 (beta = 0.0035, P = 4.90 x 10(-15)), an SNP previously associated with circulating n-3 and n-6 polyunsaturated fatty acid concentrations.	Fatty Acids, Unsaturated	270-296	fatty acid desaturase 1	Homo sapiens	93-106
25551801-5	2015	n-3 polyunsaturated fatty acids (PUFAs) intake reduces the production of apoB-48-containing lipoproteins as well as of VLDL apoB-100 and increases their conversion into smaller lipoproteins.	Fatty Acids, Unsaturated	33-38	apolipoprotein B	Homo sapiens	124-132
25459884-7	2015	The polyunsaturated fatty acids (PUFAs), particularly long-chain PUFAs (long-chain PUFA-arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid), play an important and beneficial physiologic role in the offspring who receive this fatty acid during critical periods of development.	Fatty Acids, Unsaturated	4-31	pumilio RNA binding family member 3	Homo sapiens	33-37
25366345-4	2015	The Dicer1 cKO epididymis displayed an altered lipid homeostasis associated with a 0.6-fold reduction in the expression of the gene elongation of very long chain fatty acids-like 2, an enzyme needed for production of long-chain polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	257-262	dicer 1, ribonuclease type III	Mus musculus	4-10
25387853-8	2015	An UFA- and cornstarch-deficient diet caused severe AD-like pruritus comparable to HR-AD, despite weak Th2 immune responses and absence of immunoglobulin E production.	Fatty Acids, Unsaturated	3-6	heart and neural crest derivatives expressed 2	Mus musculus	103-106
25266238-5	2015	With increase in severity of CS especially in non-acclimated plants, LOX activity decreased along with an increase in MDA and other responses helped increase or maintaine unsaturated fatty acids (FAs) whereas in acclimated plants (moderate CS), increasing of LOX activity along with a decrease in MDA indicates probably its role in secondary metabolites like jasmonic acid signaling pathway.	Fatty Acids, Unsaturated	171-194	LOC543232	Triticum aestivum	69-72
25449400-9	2015	Our results firstly showed the synchronously altered balance of tPA/PAI-1 system in the prefrontal cortex and hippocampus of CUMS rats, which was partly ameliorated by PUFAs and sertraline medication, providing new evidence for the involvement of tPA/PAI-1 system in the progression and treatment of depression.	Fatty Acids, Unsaturated	168-173	plasminogen activator, tissue type	Rattus norvegicus	64-67
25449400-9	2015	Our results firstly showed the synchronously altered balance of tPA/PAI-1 system in the prefrontal cortex and hippocampus of CUMS rats, which was partly ameliorated by PUFAs and sertraline medication, providing new evidence for the involvement of tPA/PAI-1 system in the progression and treatment of depression.	Fatty Acids, Unsaturated	168-173	serpin family E member 1	Rattus norvegicus	68-73
25557464-0	2015	The TOC159 mutant of Arabidopsis thaliana accumulates altered levels of saturated and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	86-113	translocon at the outer envelope membrane of chloroplasts 159	Arabidopsis thaliana	4-10
25449400-9	2015	Our results firstly showed the synchronously altered balance of tPA/PAI-1 system in the prefrontal cortex and hippocampus of CUMS rats, which was partly ameliorated by PUFAs and sertraline medication, providing new evidence for the involvement of tPA/PAI-1 system in the progression and treatment of depression.	Fatty Acids, Unsaturated	168-173	plasminogen activator, tissue type	Rattus norvegicus	247-250
25449400-9	2015	Our results firstly showed the synchronously altered balance of tPA/PAI-1 system in the prefrontal cortex and hippocampus of CUMS rats, which was partly ameliorated by PUFAs and sertraline medication, providing new evidence for the involvement of tPA/PAI-1 system in the progression and treatment of depression.	Fatty Acids, Unsaturated	168-173	serpin family E member 1	Rattus norvegicus	251-256
26002735-0	2015	Cytochrome p450 enzymes in the bioactivation of polyunsaturated Fatty acids and their role in cardiovascular disease.	Fatty Acids, Unsaturated	48-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
25550510-2	2015	sEH limits tissue levels of cytochrome P450 (CYP) epoxides derived from omega-6 and omega-3 polyunsaturated fatty acids (PUFA) by converting these antiinflammatory mediators into their less active diols.	Fatty Acids, Unsaturated	121-125	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
25791258-4	2015	VLDL-PC in particular contributes to the organism"s supply with polyunsaturated fatty acids (LC-PUFA), namely arachidonic (C20:4) and docosahexaenoic acid (C22:6).	Fatty Acids, Unsaturated	64-91	pumilio RNA binding family member 3	Homo sapiens	96-100
26700591-3	2015	Here, we show that a branched-chain C-20 polyunsaturated fatty acid, geranylgeranoic acid (GGA), induces upregulation of the cellular protein levels of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2) in human hepatoma-derived HuH-7cells harboring the mutant TP53 gene, suggesting that GGA may shift an energetic state of the tumor cells from aerobic glycolysis to mitochondrial respiration.	Fatty Acids, Unsaturated	41-67	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	152-199
26700591-3	2015	Here, we show that a branched-chain C-20 polyunsaturated fatty acid, geranylgeranoic acid (GGA), induces upregulation of the cellular protein levels of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2) in human hepatoma-derived HuH-7cells harboring the mutant TP53 gene, suggesting that GGA may shift an energetic state of the tumor cells from aerobic glycolysis to mitochondrial respiration.	Fatty Acids, Unsaturated	41-67	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	201-206
26700591-3	2015	Here, we show that a branched-chain C-20 polyunsaturated fatty acid, geranylgeranoic acid (GGA), induces upregulation of the cellular protein levels of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2) in human hepatoma-derived HuH-7cells harboring the mutant TP53 gene, suggesting that GGA may shift an energetic state of the tumor cells from aerobic glycolysis to mitochondrial respiration.	Fatty Acids, Unsaturated	41-67	synthesis of cytochrome C oxidase 2	Homo sapiens	249-253
26700591-3	2015	Here, we show that a branched-chain C-20 polyunsaturated fatty acid, geranylgeranoic acid (GGA), induces upregulation of the cellular protein levels of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2) in human hepatoma-derived HuH-7cells harboring the mutant TP53 gene, suggesting that GGA may shift an energetic state of the tumor cells from aerobic glycolysis to mitochondrial respiration.	Fatty Acids, Unsaturated	41-67	tumor protein p53	Homo sapiens	152-156
25572553-1	2015	Phospholipase A2s (PLA2s) are a group of enzymes that hydrolyze the sn-2 position of phospholipids to release (typically unsaturated) fatty acids and lysophospholipids, which serve as precursors for a variety of bioactive lipid mediators.	Fatty Acids, Unsaturated	121-145	phospholipase A2, group IB, pancreas	Mus musculus	0-16
25975007-1	2015	BACKGROUND: We hypothesized that dietary polyunsaturated fatty acids (PUFA) could affect the expression of serum fatty acid binding protein 5 (FABP5) and CD36 levels and also fatty acid synthase (FAS), and estrogen receptor (ER) expressions in breast cancer cells.	Fatty Acids, Unsaturated	41-68	estrogen receptor 1	Rattus norvegicus	206-223
25975007-1	2015	BACKGROUND: We hypothesized that dietary polyunsaturated fatty acids (PUFA) could affect the expression of serum fatty acid binding protein 5 (FABP5) and CD36 levels and also fatty acid synthase (FAS), and estrogen receptor (ER) expressions in breast cancer cells.	Fatty Acids, Unsaturated	70-74	estrogen receptor 1	Rattus norvegicus	206-223
25975008-1	2015	BACKGROUND: To investigate the effect of different ratios of n-6/n-3 polyunsaturated fatty acids (PUFAs) on the expression of lipid metabolic genes and estrogen receptor (ER).	Fatty Acids, Unsaturated	98-103	estrogen receptor 1	Homo sapiens	152-169
25975008-1	2015	BACKGROUND: To investigate the effect of different ratios of n-6/n-3 polyunsaturated fatty acids (PUFAs) on the expression of lipid metabolic genes and estrogen receptor (ER).	Fatty Acids, Unsaturated	98-103	estrogen receptor 1	Homo sapiens	171-173
25700720-9	2015	FGF23 levels showed a strong positive correlation with age, indicators of dyslipidaemia (LDL cholesterol, polyunsaturated fatty acids and monounsaturated fatty acids), HALS parameters (trunk/appendicular fat ratio), insulin resistance (fasting insulin and homeostasis model assessment of insulin resistance) and C-reactive protein.	Fatty Acids, Unsaturated	106-133	fibroblast growth factor 23	Homo sapiens	0-5
25147112-8	2015	These observations strengthens the hypothesis that physical properties of these microdomains modulate the convergence of amyloidogenic machinery toward lipid rafts, and also points to a critical role of polyunsaturated fatty acids in amyloidogenic processing of AbetaPP.	Fatty Acids, Unsaturated	203-230	amyloid beta precursor protein	Homo sapiens	262-269
25465571-4	2015	Milk from organically managed cows contains higher levels of vitamins, antioxidants, and unsaturated fatty acids than conventionally produced milk, but we know of no study with analogous comparisons of major phospholipid contents.	Fatty Acids, Unsaturated	89-112	Weaning weight-maternal milk	Bos taurus	0-4
25448610-0	2015	Polyunsaturated fatty acid supplementation reverses cystic fibrosis-related fatty acid abnormalities in CFTR-/- mice by suppressing fatty acid desaturases.	Fatty Acids, Unsaturated	0-26	cystic fibrosis transmembrane conductance regulator	Mus musculus	104-108
25763508-0	2015	Combined Sepiapterin Reductase and Methylmalonyl-CoA Epimerase Deficiency in a Second Patient: Cerebrospinal Fluid Polyunsaturated Fatty Acid Level and Follow-Up Under L-DOPA, 5-HTP and BH4 Trials.	Fatty Acids, Unsaturated	115-141	sepiapterin reductase	Homo sapiens	9-30
25264165-0	2014	Binding of polyunsaturated fatty acids to LXRalpha and modulation of SREBP-1 interaction with a specific SCD1 promoter element.	Fatty Acids, Unsaturated	11-38	nuclear receptor subfamily 1 group H member 3	Homo sapiens	42-50
26591564-4	2015	Active uptake of polyenoic FA (PUFA) required the following: a) PUFA re-esterified from polar phospholipids into nonpolar cholesteryl polyesters (poly-CLE), b) a novel protein, cholesteryl ester transfer protein (CETP), initiated poly-CLE transformation from HDL to LDL.	Fatty Acids, Unsaturated	31-35	cholesteryl ester transfer protein	Oryctolagus cuniculus	213-217
25281202-4	2014	We also examined the role of astrocytes in CPSP due to their effects in mediating the release of polyunsaturated fatty acids, which act as potential GPR40 ligands.	Fatty Acids, Unsaturated	97-124	free fatty acid receptor 1	Mus musculus	149-154
25914592-6	2014	Microsomal omega-3-fatty acid desaturase (FAD3) is responsible for the synthesis of alpha-linolenic acid in the polyunsaturated fatty acid pathway.	Fatty Acids, Unsaturated	112-138	microsomal omega-3-fatty acid desaturase	Glycine max	0-40
25914592-6	2014	Microsomal omega-3-fatty acid desaturase (FAD3) is responsible for the synthesis of alpha-linolenic acid in the polyunsaturated fatty acid pathway.	Fatty Acids, Unsaturated	112-138	omega-3 fatty acid desaturase, endoplasmic reticulum	Glycine max	42-46
25541716-1	2014	GPR120 (Ffar4) has been postulated to represent an important receptor mediating the improved metabolic profile seen upon ingestion of a diet enriched in polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	153-180	free fatty acid receptor 4	Mus musculus	0-6
25541716-1	2014	GPR120 (Ffar4) has been postulated to represent an important receptor mediating the improved metabolic profile seen upon ingestion of a diet enriched in polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	153-180	free fatty acid receptor 4	Mus musculus	8-13
25264165-0	2014	Binding of polyunsaturated fatty acids to LXRalpha and modulation of SREBP-1 interaction with a specific SCD1 promoter element.	Fatty Acids, Unsaturated	11-38	stearoyl-CoA desaturase	Homo sapiens	105-109
25264165-1	2014	Stearoyl-CoA desaturase 1 (SCD1) is the rate limiting enzyme in unsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	64-86	stearoyl-CoA desaturase	Homo sapiens	0-25
25264165-1	2014	Stearoyl-CoA desaturase 1 (SCD1) is the rate limiting enzyme in unsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	64-86	stearoyl-CoA desaturase	Homo sapiens	27-31
25351954-3	2014	METHODS: Therefore, we analysed the effects of PCSK5 on HDL-C and investigated the association between genetic variation in PCSK5 and dietary polyunsaturated fatty acids (PUFAs) intakes in Korean adults and children.	Fatty Acids, Unsaturated	142-169	proprotein convertase subtilisin/kexin type 5	Homo sapiens	124-129
25218830-0	2014	Enhanced reduction in oxidative stress and altered glutathione and thioredoxin system response to unsaturated fatty acid load in familial hypercholesterolemia.	Fatty Acids, Unsaturated	98-120	thioredoxin	Homo sapiens	67-78
25218830-0	2014	Enhanced reduction in oxidative stress and altered glutathione and thioredoxin system response to unsaturated fatty acid load in familial hypercholesterolemia.	Fatty Acids, Unsaturated	98-120	low density lipoprotein receptor	Homo sapiens	129-158
25459902-1	2014	Interest has been increasing to enhance the contents of healthy polyunsaturated fatty acid (PUFA) in milk.	Fatty Acids, Unsaturated	92-96	PUFA	Bos taurus	64-90
25351954-0	2014	Intake levels of dietary polyunsaturated fatty acids modify the association between the genetic variation in PCSK5 and HDL cholesterol.	Fatty Acids, Unsaturated	25-52	proprotein convertase subtilisin/kexin type 5	Homo sapiens	109-114
25351954-7	2014	Additionally, the interaction between the PCSK5 rs1029035 genotype and dietary polyunsaturated fatty acids intake influenced serum HDL-C concentrations in men (adults, p=0.001; children, p=0.008).	Fatty Acids, Unsaturated	79-106	proprotein convertase subtilisin/kexin type 5	Homo sapiens	42-47
25156894-0	2014	Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: replication in two populations.	Fatty Acids, Unsaturated	42-69	lipoprotein lipase	Homo sapiens	0-18
25293351-0	2014	Dietary supplementation with polyunsaturated fatty acid during pregnancy modulates DNA methylation at IGF2/H19 imprinted genes and growth of infants.	Fatty Acids, Unsaturated	29-55	insulin like growth factor 2	Homo sapiens	102-106
25293351-0	2014	Dietary supplementation with polyunsaturated fatty acid during pregnancy modulates DNA methylation at IGF2/H19 imprinted genes and growth of infants.	Fatty Acids, Unsaturated	29-55	H19 imprinted maternally expressed transcript	Homo sapiens	107-110
25138176-5	2014	Locomotion assays showed that the defective O2-ON response of C20-PUFA (polyunsaturated fatty acid)-deficient, Delta-12 and Delta-6 fatty acid desaturase mutants (fat-2 and fat-3 respectively) can be restored by feeding the nematodes AA or EPA, but not ETYA (eicosatetraynoic acid), a non-metabolizable AA analogue.	Fatty Acids, Unsaturated	66-70	Delta(12) fatty acid desaturase fat-2	Caenorhabditis elegans	163-168
25301203-3	2014	Linoleic acid (LA) is an essential polyunsaturated fatty acid that induces expression of plasminogen activator inhibitor-1, proliferation, migration and invasion in breast cancer cells.	Fatty Acids, Unsaturated	35-61	serpin family E member 1	Homo sapiens	89-122
25484856-6	2014	Our results show that a higher Omega-3:Omega-6 PUFA diet ratio increased hippocampal PUFA, increased anxiety, improved hippocampal dependent spatial memory and reduced hippocampal TNF-alpha levels compared to a low Omega-3:Omega-6 diet.	Fatty Acids, Unsaturated	47-51	tumor necrosis factor	Mus musculus	180-189
25138176-5	2014	Locomotion assays showed that the defective O2-ON response of C20-PUFA (polyunsaturated fatty acid)-deficient, Delta-12 and Delta-6 fatty acid desaturase mutants (fat-2 and fat-3 respectively) can be restored by feeding the nematodes AA or EPA, but not ETYA (eicosatetraynoic acid), a non-metabolizable AA analogue.	Fatty Acids, Unsaturated	72-98	Delta(12) fatty acid desaturase fat-2	Caenorhabditis elegans	163-168
25175736-6	2014	Interestingly, UFAs, especially omega-3 FAs, inhibit NLRP3 inflammasome activation in various settings.	Fatty Acids, Unsaturated	15-19	NLR family pyrin domain containing 3	Homo sapiens	53-58
25398022-6	2014	The plasma concentration of the n-3 PUFA metabolite, resolvin D1 was higher in angiotensin II-infused ApoE-/- mice fed the high, compared to the low n-3 PUFA diet.	Fatty Acids, Unsaturated	36-40	apolipoprotein E	Mus musculus	102-106
24607879-0	2014	Association between neurotrophin 4 and long-chain polyunsaturated fatty acid levels in mid-trimester amniotic fluid.	Fatty Acids, Unsaturated	50-76	neurotrophin 4	Homo sapiens	20-34
25173718-1	2014	OBJECTIVE: The association between imbalance of polyunsaturated fatty acids (PUFAs), especially low plasma n-3 to n-6 PUFA ratio, and risk of cardiovascular diseases is well known.	Fatty Acids, Unsaturated	48-75	pumilio RNA binding family member 3	Homo sapiens	77-81
25280414-9	2014	The association with 1-y mortality was significant for both polyunsaturated fatty acids (PUFA; adjusted hazard ratio [HR], 0.67; 95% confidence interval [CI].	Fatty Acids, Unsaturated	60-87	pumilio RNA binding family member 3	Homo sapiens	89-93
25359512-1	2014	BACKGROUND: The polyunsaturated fatty acid, docosahexaenoic acid (DHA), participates in neurotransmission involving activation of calcium-independent phospholipase A2 (iPLA2), which is coupled to muscarinic, cholinergic and serotonergic neuroreceptors.	Fatty Acids, Unsaturated	16-42	phospholipase A2 group VI	Rattus norvegicus	130-166
25247845-1	2014	Protectin D1 (PD1 (3)), a C22-dihydroxylated polyunsaturated fatty acid biosynthesized from all-Z-docosahexaenoic acid, belongs to the new family of endogenous mediators referred to as specialized pro-resolving lipid mediators.	Fatty Acids, Unsaturated	45-71	programmed cell death 1	Homo sapiens	14-17
25359512-1	2014	BACKGROUND: The polyunsaturated fatty acid, docosahexaenoic acid (DHA), participates in neurotransmission involving activation of calcium-independent phospholipase A2 (iPLA2), which is coupled to muscarinic, cholinergic and serotonergic neuroreceptors.	Fatty Acids, Unsaturated	16-42	phospholipase A2 group VI	Rattus norvegicus	168-173
26461321-5	2014	It was also revealed that the sera from the MFG-E8(-/-) mice exclusively cross-reacted with the protein-bound 4-oxo-2-nonenal (ONE), a highly reactive aldehyde originating from the peroxidation of ?6 polyunsaturated fatty acids.	Fatty Acids, Unsaturated	200-227	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	44-50
24972532-5	2014	PNPLA3 (I148M) minor allele carriers had an increased n-3 polyunsaturated fatty acid (PUFA) alpha-linolenic acid content and reductions in several n-6 PUFAs in the liver TAG fraction.	Fatty Acids, Unsaturated	86-90	patatin like phospholipase domain containing 3	Homo sapiens	0-6
25178286-4	2014	The GG and CC genotypes of g.78 G&gt;A and g.184 C&gt;T had higher unsaturated fatty acid (UFA) and monounsaturated fatty acid (MUFA) content (p&lt;0.05).	Fatty Acids, Unsaturated	91-94	MUFA	Bos taurus	128-132
24138546-3	2014	The present study aimed to investigate the effect of two plant oils rich in polyunsaturated fatty acids (PUFA), with different content of omega-3 fatty acids, on adiponectin levels, glucose and lipid metabolism in T2DM individuals treated either with insulin or oral anti-diabetics (OAD).	Fatty Acids, Unsaturated	76-103	adiponectin, C1Q and collagen domain containing	Homo sapiens	162-173
25046614-1	2014	During pregnancy and lactation, metabolic adaptations involve changes in expression of desaturases and elongases (Elovl2 and Elovl5) in the mammary gland and liver for the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic acid (AA) required for fetal and postnatal growth.	Fatty Acids, Unsaturated	196-223	ELOVL fatty acid elongase 2	Rattus norvegicus	114-120
25046614-1	2014	During pregnancy and lactation, metabolic adaptations involve changes in expression of desaturases and elongases (Elovl2 and Elovl5) in the mammary gland and liver for the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic acid (AA) required for fetal and postnatal growth.	Fatty Acids, Unsaturated	196-223	ELOVL fatty acid elongase 5	Rattus norvegicus	125-131
26461420-3	2014	Notably, electrophilic products of unsaturated fatty acid oxidation and nitration can elicit cytoprotective responses such as those regulated by the Keap1-Nrf2-ARE pathway.	Fatty Acids, Unsaturated	35-57	kelch like ECH associated protein 1	Homo sapiens	149-154
26461420-3	2014	Notably, electrophilic products of unsaturated fatty acid oxidation and nitration can elicit cytoprotective responses such as those regulated by the Keap1-Nrf2-ARE pathway.	Fatty Acids, Unsaturated	35-57	NFE2 like bZIP transcription factor 2	Homo sapiens	155-159
24138546-3	2014	The present study aimed to investigate the effect of two plant oils rich in polyunsaturated fatty acids (PUFA), with different content of omega-3 fatty acids, on adiponectin levels, glucose and lipid metabolism in T2DM individuals treated either with insulin or oral anti-diabetics (OAD).	Fatty Acids, Unsaturated	105-109	adiponectin, C1Q and collagen domain containing	Homo sapiens	162-173
25167836-6	2014	Analysis of molecular species of PtdCho hydrolyzed by EL in the lipoproteins showed that the enzyme preferentially hydrolyzed PtdCho containing polyunsaturated fatty acids (PUFA) such as 22:6, 20:5, 20:4 at the sn-2 position, generating the corresponding PUFA-lyso PtdCho.	Fatty Acids, Unsaturated	144-171	lipase G, endothelial type	Homo sapiens	54-56
25250621-1	2014	The G-protein-coupled receptor 120 (GPR120) is a receptor for polyunsaturated fatty acids with anti-inflammatory activity.	Fatty Acids, Unsaturated	62-89	free fatty acid receptor 4	Homo sapiens	4-34
25250621-1	2014	The G-protein-coupled receptor 120 (GPR120) is a receptor for polyunsaturated fatty acids with anti-inflammatory activity.	Fatty Acids, Unsaturated	62-89	free fatty acid receptor 4	Homo sapiens	36-42
25236365-2	2014	Polyunsaturated fatty acids (PUFAs) have been used to treat DES; however, randomized controlled trials (RCTs) of PUFA therapy yield discordant results.	Fatty Acids, Unsaturated	0-27	pumilio RNA binding family member 3	Homo sapiens	29-33
25060692-9	2014	Several unsaturated fatty acids each significantly decreased Pnpla3 mRNA, similar to lipid emulsion in vivo.	Fatty Acids, Unsaturated	8-31	patatin like phospholipase domain containing 3	Homo sapiens	61-67
25060692-12	2014	Under lipogenic conditions due to high-carbohydrate feeding, certain unsaturated fatty acids can effectively suppress both lipogenesis and PNPLA3 expression, both in vivo and in a hepatocyte cell line.	Fatty Acids, Unsaturated	69-92	patatin like phospholipase domain containing 3	Homo sapiens	139-145
24847004-1	2014	Dienoyl-CoA reductase (DECR) deficiency with hyperlysinemia is a rare disorder affecting the metabolism of polyunsaturated fatty acids and lysine.	Fatty Acids, Unsaturated	107-134	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-21
24847004-1	2014	Dienoyl-CoA reductase (DECR) deficiency with hyperlysinemia is a rare disorder affecting the metabolism of polyunsaturated fatty acids and lysine.	Fatty Acids, Unsaturated	107-134	2,4-dienoyl-CoA reductase 1	Homo sapiens	23-27
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	early growth response 1	Homo sapiens	122-126
25203168-3	2014	Here we report that nutritional n-3 polyunsaturated fatty acids (PUFA) deficiency induces a chronic stress state reflected by disrupted glucocorticoid receptor (GR)-mediated signalling pathway along with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity.	Fatty Acids, Unsaturated	65-69	nuclear receptor subfamily 3, group C, member 1	Mus musculus	136-159
25203168-3	2014	Here we report that nutritional n-3 polyunsaturated fatty acids (PUFA) deficiency induces a chronic stress state reflected by disrupted glucocorticoid receptor (GR)-mediated signalling pathway along with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity.	Fatty Acids, Unsaturated	65-69	nuclear receptor subfamily 3, group C, member 1	Mus musculus	161-163
25203508-6	2014	The intrinsic NAD(+)- and CoA-dependent activity of the HSD17B8 subunit on the 3R-hydroxyacyl-CoA intermediates may indicate a role for this subunit in routing 3R-hydroxyacyl-CoA esters, potentially arising from the metabolism of unsaturated fatty acids, into the mitochondrial beta-oxidation pathway.	Fatty Acids, Unsaturated	230-253	hydroxysteroid 17-beta dehydrogenase 8	Homo sapiens	56-63
25058871-0	2014	Interferon-alpha2b against microbes through promoting biosynthesis of unsaturated fatty acids.	Fatty Acids, Unsaturated	70-93	interferon phi 1	Danio rerio	0-10
25058871-6	2014	Further dose-related metabolites indicate that biosynthesis of unsaturated fatty acids is enriched only in IFN-M and IFN-H, which is related to high protection against bacterial infection.	Fatty Acids, Unsaturated	63-86	interferon phi 1	Danio rerio	107-110
25058871-6	2014	Further dose-related metabolites indicate that biosynthesis of unsaturated fatty acids is enriched only in IFN-M and IFN-H, which is related to high protection against bacterial infection.	Fatty Acids, Unsaturated	63-86	interferon phi 1	Danio rerio	117-120
25222270-1	2014	Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	159-186	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
25222270-1	2014	Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	159-186	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	tumor necrosis factor	Homo sapiens	128-137
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	notch receptor 1	Homo sapiens	139-145
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	147-152
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	tumor protein p53	Homo sapiens	154-158
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	heme oxygenase 1	Homo sapiens	160-165
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	aldo-keto reductase family 1 member C1	Homo sapiens	167-173
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	NAD(P)H quinone dehydrogenase 1	Homo sapiens	175-179
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	growth arrest and DNA damage inducible alpha	Homo sapiens	204-211
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	early growth response 1	Homo sapiens	213-217
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	heat shock protein family A (Hsp70) member 5	Homo sapiens	219-224
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	DNA damage inducible transcript 3	Homo sapiens	226-231
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	233-238
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	240-245
25182732-5	2014	The collective application of polyunsaturated fatty acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-alpha, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA treatment or irradiation alone.	Fatty Acids, Unsaturated	30-57	pumilio RNA binding family member 3	Homo sapiens	59-63
25065913-8	2014	ELOVL5 encodes an elongase involved in the synthesis of polyunsaturated fatty acids of the omega3 and omega6 series.	Fatty Acids, Unsaturated	56-83	ELOVL fatty acid elongase 5	Homo sapiens	0-6
24839911-6	2014	The most active PUFAs, docosahexaenoic acid (DHA) and arachidonic acid (AA) reduced the level of active RhoA and increased the G/F-actin ratio.	Fatty Acids, Unsaturated	16-21	ras homolog family member A	Homo sapiens	104-108
25056921-2	2014	By expressing the caleosin RESPONSIVE TO DESSICATION20 (RD20) in Saccharomyces cerevisiae, we show that the recombinant protein possesses an unusual peroxygenase activity with restricted specificity toward hydroperoxides of unsaturated fatty acid.	Fatty Acids, Unsaturated	224-246	Caleosin-related family protein	Arabidopsis thaliana	56-60
25043761-11	2014	Interestingly, the role of ABCD2 (in homo- and heterodimeric forms) in the metabolism of polyunsaturated fatty acids is clearly evidenced, and the chimeric dimers provide a novel tool to study substrate specificity of peroxisomal ATP-binding cassette transporters.	Fatty Acids, Unsaturated	89-116	ATP binding cassette subfamily D member 2	Homo sapiens	27-32
24904960-1	2014	Stearoyl-CoA desaturase 1 (SCD1) greatly contributes to the unsaturated fatty acids present in milk and meat of cattle.	Fatty Acids, Unsaturated	60-83	stearoyl-CoA desaturase	Bos taurus	0-25
24769339-0	2014	Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca(2+) sensor STIM1 and the Ca(2+) channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization.	Fatty Acids, Unsaturated	0-27	stromal interaction molecule 1	Homo sapiens	187-192
24769339-1	2014	Polyunsaturated fatty acids (PUFAs) have been found to be effective inhibitors of cell signaling in numerous contexts, and we find that acute addition of micromolar PUFAs such as linoleic acid effectively inhibit of Ca(2+) responses in mast cells stimulated by antigen-mediated crosslinking of FcepsilonRI or by the SERCA pump inhibitor, thapsigargin.	Fatty Acids, Unsaturated	0-27	Fc epsilon receptor Ia	Homo sapiens	294-305
24769339-1	2014	Polyunsaturated fatty acids (PUFAs) have been found to be effective inhibitors of cell signaling in numerous contexts, and we find that acute addition of micromolar PUFAs such as linoleic acid effectively inhibit of Ca(2+) responses in mast cells stimulated by antigen-mediated crosslinking of FcepsilonRI or by the SERCA pump inhibitor, thapsigargin.	Fatty Acids, Unsaturated	29-34	Fc epsilon receptor Ia	Homo sapiens	294-305
24769339-7	2014	We hypothesize that linoleic acid and related PUFAs inhibit STIM1-Orai1 coupling by a mechanism that involves perturbation of ER membrane structure, possibly by disrupting electrostatic interactions important in STIM1 oligomerization.	Fatty Acids, Unsaturated	46-51	stromal interaction molecule 1	Homo sapiens	60-65
24769339-7	2014	We hypothesize that linoleic acid and related PUFAs inhibit STIM1-Orai1 coupling by a mechanism that involves perturbation of ER membrane structure, possibly by disrupting electrostatic interactions important in STIM1 oligomerization.	Fatty Acids, Unsaturated	46-51	ORAI calcium release-activated calcium modulator 1	Homo sapiens	66-71
24769339-7	2014	We hypothesize that linoleic acid and related PUFAs inhibit STIM1-Orai1 coupling by a mechanism that involves perturbation of ER membrane structure, possibly by disrupting electrostatic interactions important in STIM1 oligomerization.	Fatty Acids, Unsaturated	46-51	stromal interaction molecule 1	Homo sapiens	212-217
24448975-1	2014	BACKGROUND: Long-chain polyunsaturated fatty acids (LC-PUFA), particularly docosahexaenoic acid (DHA) and arachidonic acid, are, respectively, n-3 and n-6 family members and play an important role in fetal and infant growth and development.	Fatty Acids, Unsaturated	23-50	pumilio RNA binding family member 3	Homo sapiens	55-59
25100256-2	2014	It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to form hydroperoxides.	Fatty Acids, Unsaturated	103-126	linoleate 9S-lipoxygenase-4	Glycine max	17-20
24769906-6	2014	The resulting strain  faa1 faa4 [Acot5s] accumulated more extracellular FFA with higher unsaturated fatty acid (UFA) ratio as compared to the wild-type strain and double deletion strain  faa1 faa4.	Fatty Acids, Unsaturated	88-110	long-chain fatty acid-CoA ligase FAA1	Saccharomyces cerevisiae S288C	22-31
24769906-6	2014	The resulting strain  faa1 faa4 [Acot5s] accumulated more extracellular FFA with higher unsaturated fatty acid (UFA) ratio as compared to the wild-type strain and double deletion strain  faa1 faa4.	Fatty Acids, Unsaturated	88-110	acyl-CoA thioesterase 5	Mus musculus	33-39
24769906-6	2014	The resulting strain  faa1 faa4 [Acot5s] accumulated more extracellular FFA with higher unsaturated fatty acid (UFA) ratio as compared to the wild-type strain and double deletion strain  faa1 faa4.	Fatty Acids, Unsaturated	112-115	long-chain fatty acid-CoA ligase FAA1	Saccharomyces cerevisiae S288C	22-31
24769906-6	2014	The resulting strain  faa1 faa4 [Acot5s] accumulated more extracellular FFA with higher unsaturated fatty acid (UFA) ratio as compared to the wild-type strain and double deletion strain  faa1 faa4.	Fatty Acids, Unsaturated	112-115	acyl-CoA thioesterase 5	Mus musculus	33-39
24769906-8	2014	UFA accounted for 42 % of TFA in the strain  faa1 faa4 [Acot5s], while no UFA was detected in the wild-type strain.	Fatty Acids, Unsaturated	0-3	long-chain fatty acid-CoA ligase FAA1	Saccharomyces cerevisiae S288C	45-54
24769906-8	2014	UFA accounted for 42 % of TFA in the strain  faa1 faa4 [Acot5s], while no UFA was detected in the wild-type strain.	Fatty Acids, Unsaturated	0-3	acyl-CoA thioesterase 5	Mus musculus	56-62
24769339-0	2014	Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca(2+) sensor STIM1 and the Ca(2+) channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization.	Fatty Acids, Unsaturated	0-27	stromal interaction molecule 1	Homo sapiens	85-90
24769339-0	2014	Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca(2+) sensor STIM1 and the Ca(2+) channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization.	Fatty Acids, Unsaturated	0-27	ORAI calcium release-activated calcium modulator 1	Homo sapiens	122-127
24904960-1	2014	Stearoyl-CoA desaturase 1 (SCD1) greatly contributes to the unsaturated fatty acids present in milk and meat of cattle.	Fatty Acids, Unsaturated	60-83	stearoyl-CoA desaturase	Bos taurus	27-31
24814604-1	2014	Because scavenger receptor class B type 1 is the cholesterol uptake liver receptor, whereas peroxisome proliferator-activated receptor gamma coactivator-1beta (PGC-1beta) and PGC-1alpha are critical for lipid synthesis and degradation, we investigated the roles of these signaling molecules in the actions of ethanol-polyunsaturated fatty acids and betaine on hepatosteatosis and steatohepatitis.	Fatty Acids, Unsaturated	317-344	PPARG coactivator 1 beta	Rattus norvegicus	160-169
24944284-3	2014	Previously, we demonstrated that n-3 (omega-3) polyunsaturated fatty acids (PUFAs) reduce CD4(+) T-cell activation and differentiation into pathogenic Th17 cells by 25-30%.	Fatty Acids, Unsaturated	76-81	CD4 antigen	Mus musculus	90-93
24794156-7	2014	Mechanistically, n-3 PUFAs induced upregulation of angiopoietin 2 (Ang 2) in astrocytes after tFCI and stimulated extracellular Ang 2 release from cultured astrocytes after oxygen and glucose deprivation.	Fatty Acids, Unsaturated	21-26	angiopoietin 2	Mus musculus	51-65
24794156-7	2014	Mechanistically, n-3 PUFAs induced upregulation of angiopoietin 2 (Ang 2) in astrocytes after tFCI and stimulated extracellular Ang 2 release from cultured astrocytes after oxygen and glucose deprivation.	Fatty Acids, Unsaturated	21-26	angiopoietin 2	Mus musculus	67-72
24794156-7	2014	Mechanistically, n-3 PUFAs induced upregulation of angiopoietin 2 (Ang 2) in astrocytes after tFCI and stimulated extracellular Ang 2 release from cultured astrocytes after oxygen and glucose deprivation.	Fatty Acids, Unsaturated	21-26	angiopoietin 2	Mus musculus	128-133
24893149-1	2014	5-Lipoxygenase (5-LOX) reacts with arachidonic acid (AA) to first generate 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid [5(S)-HpETE] and then an epoxide from 5(S)-HpETE to form leukotriene A4, from a single polyunsaturated fatty acid.	Fatty Acids, Unsaturated	223-249	arachidonate 5-lipoxygenase	Homo sapiens	0-14
24893149-1	2014	5-Lipoxygenase (5-LOX) reacts with arachidonic acid (AA) to first generate 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid [5(S)-HpETE] and then an epoxide from 5(S)-HpETE to form leukotriene A4, from a single polyunsaturated fatty acid.	Fatty Acids, Unsaturated	223-249	arachidonate 5-lipoxygenase	Homo sapiens	16-21
24814604-1	2014	Because scavenger receptor class B type 1 is the cholesterol uptake liver receptor, whereas peroxisome proliferator-activated receptor gamma coactivator-1beta (PGC-1beta) and PGC-1alpha are critical for lipid synthesis and degradation, we investigated the roles of these signaling molecules in the actions of ethanol-polyunsaturated fatty acids and betaine on hepatosteatosis and steatohepatitis.	Fatty Acids, Unsaturated	317-344	PPARG coactivator 1 alpha	Rattus norvegicus	175-185
24910243-4	2014	PLA2G5 hydrolyzed phosphatidylcholine in fat-overladen low-density lipoprotein to release unsaturated fatty acids, which prevented palmitate-induced M1 macrophage polarization.	Fatty Acids, Unsaturated	90-113	phospholipase A2, group V	Mus musculus	0-6
33412696-3	2014	To date, many applications related to the design and development of functional ice cream have been documented, including products containing probiotics, prebiotics, synbiotics, dietary fibers, natural antioxidants such as polyphenols, essential and polyunsaturated fatty acids, and low glycemic index blends and blends fortified with mineral or trace elements.	Fatty Acids, Unsaturated	249-276	carboxylesterase 2	Homo sapiens	79-82
24961717-6	2014	RESULTS: Controlling for age and total caloric intake, higher intake of vitamin B12, vitamin D and omega-3 polyunsaturated fatty acid (PUFA) was associated with lower Abeta load in AD regions on PiB-PET, while higher intake of beta-carotene and folate was associated with higher glucose metabolism on FDG-PET.	Fatty Acids, Unsaturated	135-139	amyloid beta precursor protein	Homo sapiens	167-172
24550191-3	2014	We investigated liver fat accumulation and body composition during overfeeding saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	111-138	FAT atypical cadherin 1	Homo sapiens	22-25
24697921-1	2014	This paper focuses on dietary approaches to control intramuscular fat deposition to increase beneficial omega-3 polyunsaturated fatty acids (PUFA) and conjugated linoleic acid content and reduce saturated fatty acids in beef.	Fatty Acids, Unsaturated	141-145	PUFA	Bos taurus	112-139
24703705-0	2014	Polyunsaturated fatty acids balance affects platelet NOX2 activity in patients with liver cirrhosis.	Fatty Acids, Unsaturated	0-27	cytochrome b-245 beta chain	Homo sapiens	53-57
24561579-4	2014	We hypothesized that 4-hydroxynonenal (4-HNE), a highly reactive alpha,beta-aldehydic product generated from polyunsaturated fatty acid peroxidation, could contribute to inhibiting elastin repair by antagonizing the elastogenic signaling of transforming growth factor-beta1 (TGF-beta1) in skin fibroblasts.	Fatty Acids, Unsaturated	109-135	elastin	Mus musculus	181-188
24623743-1	2014	Peroxisome proliferator-activated receptor gamma (PPARgamma, NR1C3) and testicular receptor 4 nuclear receptor (TR4, NR2C2) are two members of the nuclear receptor (NR) superfamily that can be activated by several similar ligands/activators including polyunsaturated fatty acid metabolites, such as 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatetraenoic acid, as well as some anti-diabetic drugs such as thiazolidinediones (TZDs).	Fatty Acids, Unsaturated	251-277	peroxisome proliferator activated receptor gamma	Homo sapiens	0-48
24623743-1	2014	Peroxisome proliferator-activated receptor gamma (PPARgamma, NR1C3) and testicular receptor 4 nuclear receptor (TR4, NR2C2) are two members of the nuclear receptor (NR) superfamily that can be activated by several similar ligands/activators including polyunsaturated fatty acid metabolites, such as 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatetraenoic acid, as well as some anti-diabetic drugs such as thiazolidinediones (TZDs).	Fatty Acids, Unsaturated	251-277	peroxisome proliferator activated receptor gamma	Homo sapiens	50-59
24623743-1	2014	Peroxisome proliferator-activated receptor gamma (PPARgamma, NR1C3) and testicular receptor 4 nuclear receptor (TR4, NR2C2) are two members of the nuclear receptor (NR) superfamily that can be activated by several similar ligands/activators including polyunsaturated fatty acid metabolites, such as 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatetraenoic acid, as well as some anti-diabetic drugs such as thiazolidinediones (TZDs).	Fatty Acids, Unsaturated	251-277	peroxisome proliferator activated receptor gamma	Homo sapiens	61-66
24623743-1	2014	Peroxisome proliferator-activated receptor gamma (PPARgamma, NR1C3) and testicular receptor 4 nuclear receptor (TR4, NR2C2) are two members of the nuclear receptor (NR) superfamily that can be activated by several similar ligands/activators including polyunsaturated fatty acid metabolites, such as 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatetraenoic acid, as well as some anti-diabetic drugs such as thiazolidinediones (TZDs).	Fatty Acids, Unsaturated	251-277	nuclear receptor subfamily 2 group C member 2	Homo sapiens	112-115
24623743-1	2014	Peroxisome proliferator-activated receptor gamma (PPARgamma, NR1C3) and testicular receptor 4 nuclear receptor (TR4, NR2C2) are two members of the nuclear receptor (NR) superfamily that can be activated by several similar ligands/activators including polyunsaturated fatty acid metabolites, such as 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatetraenoic acid, as well as some anti-diabetic drugs such as thiazolidinediones (TZDs).	Fatty Acids, Unsaturated	251-277	nuclear receptor subfamily 2 group C member 2	Homo sapiens	117-122
24628888-6	2014	Finally, the T94A substitution markedly decreased the levels of induction of peroxisome proliferator-activated receptor alpha-regulated proteins such as L-FABP, fatty acid transport protein 5 and peroxisome proliferator-activated receptor alpha itself meditated by the polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid in cultured primary human hepatocytes.	Fatty Acids, Unsaturated	269-296	fatty acid binding protein 1	Homo sapiens	153-159
24356795-0	2014	Effects of n-3 polyunsaturated fatty acids (PUFAs) on circulating adiponectin and leptin in subjects with type 2 diabetes mellitus.	Fatty Acids, Unsaturated	44-49	adiponectin, C1Q and collagen domain containing	Homo sapiens	66-77
24356795-0	2014	Effects of n-3 polyunsaturated fatty acids (PUFAs) on circulating adiponectin and leptin in subjects with type 2 diabetes mellitus.	Fatty Acids, Unsaturated	44-49	leptin	Homo sapiens	82-88
24702179-2	2014	The natural ligands of TR4 remained unclear until the recent discoveries of several energy/lipid sensors including the polyunsaturated fatty acid metabolites, 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatetraenoic acid, and their synthetic ligands, thiazolidinediones, used for treatment of diabetes.	Fatty Acids, Unsaturated	119-145	nuclear receptor subfamily 2, group C, member 2	Mus musculus	23-26
24819575-4	2014	RESULTS: Carriage of the minor allele at rs2518824 in the armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF) gene, which has been linked to neuronal migration and schizophrenia, and rs174576 in the fatty acid desaturase 2 gene, which encodes a rate-limiting enzyme for endogenous long chain polyunsaturated fatty acid synthesis and has been linked to intelligence, was associated with white matter abnormality measured in vivo using diffusion tensor imaging (P = .0009 and P = .0019, respectively).	Fatty Acids, Unsaturated	307-333	ARVCF delta catenin family member	Homo sapiens	118-123
24692551-6	2014	Furthermore, we show that more saturated, nonactivating fatty acids inhibit nuclear localization signal formation by destabilizing this activation loop, thus implicating FABP5 specifically in cis-bonded, polyunsaturated fatty acid signaling.	Fatty Acids, Unsaturated	204-230	fatty acid binding protein 5	Homo sapiens	170-175
25598698-0	2014	Polyunsaturated fatty acids modify expression of TGF-beta in a co-culture model ultilising human colorectal cells and human peripheral blood mononuclear cells exposed to Lactobacillus gasseri, Escherichia coli and Staphylococcus aureus.	Fatty Acids, Unsaturated	0-27	transforming growth factor beta 1	Homo sapiens	49-57
24628888-6	2014	Finally, the T94A substitution markedly decreased the levels of induction of peroxisome proliferator-activated receptor alpha-regulated proteins such as L-FABP, fatty acid transport protein 5 and peroxisome proliferator-activated receptor alpha itself meditated by the polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid in cultured primary human hepatocytes.	Fatty Acids, Unsaturated	269-296	solute carrier family 27 member 5	Homo sapiens	161-244
24353137-8	2014	Total fatty acids and unsaturated fatty acids such as oleic acid and linoleic acid showed an inverse significant correlation with insulin resistance.	Fatty Acids, Unsaturated	22-45	insulin	Homo sapiens	130-137
24729033-2	2014	Proteolysis of SREBP-2 is strictly regulated by sterols, but that of SREBP-1c was not strongly sterol-regulated, but inhibited by polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	130-157	sterol regulatory element binding transcription factor 1	Mus musculus	69-77
24729033-2	2014	Proteolysis of SREBP-2 is strictly regulated by sterols, but that of SREBP-1c was not strongly sterol-regulated, but inhibited by polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	159-164	sterol regulatory element binding transcription factor 1	Mus musculus	69-77
24362075-7	2014	In two NAFLD mouse models, treatment with rCT-1 for 10days induced a marked decrease in liver triglyceride content with augmented proportion of poly-unsaturated FA and reduction of monounsaturated species.	Fatty Acids, Unsaturated	144-163	cardiotrophin 1	Rattus norvegicus	42-47
24353137-9	2014	Children with high insulin resistance (HOMA-IR &gt;2.5) showed a decrease in unsaturated fatty acids compared with children having a HOMA-IR of &lt;2.5.	Fatty Acids, Unsaturated	77-100	insulin	Homo sapiens	19-26
24353137-11	2014	CONCLUSIONS: A decrease in unsaturated fatty acids was correlated with insulin resistance in childhood obesity.	Fatty Acids, Unsaturated	27-50	insulin	Homo sapiens	71-78
24644051-3	2014	Here we analyzed quantitatively the ELOVL4 protein and its enzymatic products (very long chain saturated fatty acid [VLC-FA] and VLC-polyunsaturated fatty acid [VLC-PUFA]) in the retinas of 8 to 10-week-old TG1(+), TG2(+), and Elovl4(+/mut) mice that harbor the mutant ELOVL4 and compared them to their wild-type littermates and Elovl4(+/-) that do not express the mutant protein.	Fatty Acids, Unsaturated	133-159	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	36-42
24716602-5	2014	The fatty acyl-ACP thioesterase (AtFatA) and fatty acid desaturase (SSI2) from Arabidopsis thaliana were heterologously expressed in E. coli BL21 star(DE3) to specifically release free unsaturated fatty acids (UFAs) and convert SFAs to UFAs.	Fatty Acids, Unsaturated	185-208	Acyl-ACP thioesterase	Arabidopsis thaliana	10-31
24531201-5	2014	Incorporation of the complexes within bovine beta-lactoglobulin (betaLG) as the protein host was studied by circular dichroism and fluorescence spectroscopy and again noticeable differences were observed between the saturated and unsaturated fatty acid derivatives.	Fatty Acids, Unsaturated	230-252	beta-lactoglobulin	Bos taurus	45-63
24716602-5	2014	The fatty acyl-ACP thioesterase (AtFatA) and fatty acid desaturase (SSI2) from Arabidopsis thaliana were heterologously expressed in E. coli BL21 star(DE3) to specifically release free unsaturated fatty acids (UFAs) and convert SFAs to UFAs.	Fatty Acids, Unsaturated	185-208	fatA acyl-ACP thioesterase	Arabidopsis thaliana	33-39
24716602-5	2014	The fatty acyl-ACP thioesterase (AtFatA) and fatty acid desaturase (SSI2) from Arabidopsis thaliana were heterologously expressed in E. coli BL21 star(DE3) to specifically release free unsaturated fatty acids (UFAs) and convert SFAs to UFAs.	Fatty Acids, Unsaturated	185-208	Plant stearoyl-acyl-carrier-protein desaturase family protein	Arabidopsis thaliana	68-72
24716602-5	2014	The fatty acyl-ACP thioesterase (AtFatA) and fatty acid desaturase (SSI2) from Arabidopsis thaliana were heterologously expressed in E. coli BL21 star(DE3) to specifically release free unsaturated fatty acids (UFAs) and convert SFAs to UFAs.	Fatty Acids, Unsaturated	210-214	Acyl-ACP thioesterase	Arabidopsis thaliana	10-31
24716602-5	2014	The fatty acyl-ACP thioesterase (AtFatA) and fatty acid desaturase (SSI2) from Arabidopsis thaliana were heterologously expressed in E. coli BL21 star(DE3) to specifically release free unsaturated fatty acids (UFAs) and convert SFAs to UFAs.	Fatty Acids, Unsaturated	210-214	fatA acyl-ACP thioesterase	Arabidopsis thaliana	33-39
24716602-5	2014	The fatty acyl-ACP thioesterase (AtFatA) and fatty acid desaturase (SSI2) from Arabidopsis thaliana were heterologously expressed in E. coli BL21 star(DE3) to specifically release free unsaturated fatty acids (UFAs) and convert SFAs to UFAs.	Fatty Acids, Unsaturated	210-214	Plant stearoyl-acyl-carrier-protein desaturase family protein	Arabidopsis thaliana	68-72
24716602-5	2014	The fatty acyl-ACP thioesterase (AtFatA) and fatty acid desaturase (SSI2) from Arabidopsis thaliana were heterologously expressed in E. coli BL21 star(DE3) to specifically release free unsaturated fatty acids (UFAs) and convert SFAs to UFAs.	Fatty Acids, Unsaturated	236-240	Acyl-ACP thioesterase	Arabidopsis thaliana	10-31
24716602-5	2014	The fatty acyl-ACP thioesterase (AtFatA) and fatty acid desaturase (SSI2) from Arabidopsis thaliana were heterologously expressed in E. coli BL21 star(DE3) to specifically release free unsaturated fatty acids (UFAs) and convert SFAs to UFAs.	Fatty Acids, Unsaturated	236-240	fatA acyl-ACP thioesterase	Arabidopsis thaliana	33-39
24716602-5	2014	The fatty acyl-ACP thioesterase (AtFatA) and fatty acid desaturase (SSI2) from Arabidopsis thaliana were heterologously expressed in E. coli BL21 star(DE3) to specifically release free unsaturated fatty acids (UFAs) and convert SFAs to UFAs.	Fatty Acids, Unsaturated	236-240	Plant stearoyl-acyl-carrier-protein desaturase family protein	Arabidopsis thaliana	68-72
24445605-3	2014	METHODS AND RESULTS: Here, we report a novel molecular pathway for membrane targeting of TREK-1, a mechano-sensitive K(2P) channel regulated by environmental and physical factors including membrane stretch, pH, and polyunsaturated fatty acids (e.g. arachidonic acid).	Fatty Acids, Unsaturated	215-242	potassium two pore domain channel subfamily K member 2	Homo sapiens	89-95
24437974-1	2014	The intake of polyunsaturated fatty acids (PUFAs) is generally linked with a reduced cardiovascular disease (CVD) risk, but an elevated n6PUFA intake, without simultaneous n3PUFA supply, may elevate the risk.	Fatty Acids, Unsaturated	14-41	pumilio RNA binding family member 3	Homo sapiens	43-47
24344334-8	2014	In vitro, Eci3 catalyzed the isomerization of trans-3-nonenoyl-CoA to trans-2-nonenoyl-CoA equally efficient as Eci2, suggesting a role in oxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	152-175	enoyl-Coenzyme A delta isomerase 3	Mus musculus	10-14
24489111-5	2014	The impaired PUFA levels positively influenced hepatic levels of the key lipogenic transcriptional regulator sterol-regulatory element binding protein 1c (SREBP-1c), as well as its downstream target genes.	Fatty Acids, Unsaturated	13-17	sterol regulatory element binding transcription factor 1	Mus musculus	109-153
24489111-5	2014	The impaired PUFA levels positively influenced hepatic levels of the key lipogenic transcriptional regulator sterol-regulatory element binding protein 1c (SREBP-1c), as well as its downstream target genes.	Fatty Acids, Unsaturated	13-17	sterol regulatory element binding transcription factor 1	Mus musculus	155-163
24176359-1	2014	Lipoxygenase (Lox) mediated oxidation of polyunsaturated fatty acids (PUFA) in mature soya seeds results in objectionable flavour.	Fatty Acids, Unsaturated	41-68	linoleate 9S-lipoxygenase-4	Glycine max	0-12
24176359-1	2014	Lipoxygenase (Lox) mediated oxidation of polyunsaturated fatty acids (PUFA) in mature soya seeds results in objectionable flavour.	Fatty Acids, Unsaturated	41-68	linoleate 9S-lipoxygenase-4	Glycine max	14-17
24176359-1	2014	Lipoxygenase (Lox) mediated oxidation of polyunsaturated fatty acids (PUFA) in mature soya seeds results in objectionable flavour.	Fatty Acids, Unsaturated	70-74	linoleate 9S-lipoxygenase-4	Glycine max	0-12
24176359-1	2014	Lipoxygenase (Lox) mediated oxidation of polyunsaturated fatty acids (PUFA) in mature soya seeds results in objectionable flavour.	Fatty Acids, Unsaturated	70-74	linoleate 9S-lipoxygenase-4	Glycine max	14-17
24632852-9	2014	CONCLUSIONS/INTERPRETATION: Beneficial gains in insulin sensitivity and the ability of unsaturated fatty acids to oppose palmitate-induced insulin resistance in muscle cells may partly be accounted for by counter-modulation of PP2A.	Fatty Acids, Unsaturated	87-110	insulin	Homo sapiens	139-146
24632852-9	2014	CONCLUSIONS/INTERPRETATION: Beneficial gains in insulin sensitivity and the ability of unsaturated fatty acids to oppose palmitate-induced insulin resistance in muscle cells may partly be accounted for by counter-modulation of PP2A.	Fatty Acids, Unsaturated	87-110	protein phosphatase 2 phosphatase activator	Homo sapiens	227-231
23957350-11	2014	Lastly, the role of MDT-15 in oxidative stress defense is functionally separable from its function in fatty acid metabolism, as exogenous polyunsaturated fatty acid complementation rescues developmental, but not stress sensitivity phenotypes of mdt-15 worms.	Fatty Acids, Unsaturated	138-164	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	20-26
24868910-2	2014	The pttg gene knockout causes a significant modification of fatty acids composition of erythrocyte membrane lipids by reducing the content of palmitic acid and increasing of polyunsaturated fatty acids amount by 18%.	Fatty Acids, Unsaturated	174-201	pituitary tumor-transforming gene 1	Mus musculus	4-8
24412271-1	2014	Free fatty acid receptor 4 (FFA4), previously known as GPR120, is a G protein-coupled receptor that promotes numerous anti-inflammatory and antidiabetic effects upon its agonism by long chained unsaturated fatty acids.	Fatty Acids, Unsaturated	194-217	free fatty acid receptor 4	Homo sapiens	0-26
24412271-1	2014	Free fatty acid receptor 4 (FFA4), previously known as GPR120, is a G protein-coupled receptor that promotes numerous anti-inflammatory and antidiabetic effects upon its agonism by long chained unsaturated fatty acids.	Fatty Acids, Unsaturated	194-217	free fatty acid receptor 4	Homo sapiens	28-32
24412271-1	2014	Free fatty acid receptor 4 (FFA4), previously known as GPR120, is a G protein-coupled receptor that promotes numerous anti-inflammatory and antidiabetic effects upon its agonism by long chained unsaturated fatty acids.	Fatty Acids, Unsaturated	194-217	free fatty acid receptor 4	Homo sapiens	55-61
23957350-11	2014	Lastly, the role of MDT-15 in oxidative stress defense is functionally separable from its function in fatty acid metabolism, as exogenous polyunsaturated fatty acid complementation rescues developmental, but not stress sensitivity phenotypes of mdt-15 worms.	Fatty Acids, Unsaturated	138-164	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	245-251
24460221-3	2014	The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain.	Fatty Acids, Unsaturated	20-43	fatty acid desaturase 1	Homo sapiens	120-125
24286221-2	2014	Consequently, ndg-4 mutants lay eggs with a pale appearance due to lack of yolk, and they are resistant to sterility caused by dietary supplementation with the long-chain omega-6 polyunsaturated fatty acid dihommogamma-linolenic acid (DGLA).	Fatty Acids, Unsaturated	179-205	NRF domain-containing protein	Caenorhabditis elegans	14-19
24554513-12	2014	Both of the poly-unsaturated fatty acids linoleic acid and arachidonic acid decreased visfatin release.Oral lipid ingestion is a physiological regulator of systemic visfatin release.	Fatty Acids, Unsaturated	12-40	nicotinamide phosphoribosyltransferase	Homo sapiens	86-94
24554513-12	2014	Both of the poly-unsaturated fatty acids linoleic acid and arachidonic acid decreased visfatin release.Oral lipid ingestion is a physiological regulator of systemic visfatin release.	Fatty Acids, Unsaturated	12-40	nicotinamide phosphoribosyltransferase	Homo sapiens	165-173
24248462-0	2014	Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHbeta gene expression.	Fatty Acids, Unsaturated	0-23	follicle stimulating hormone subunit beta	Rattus norvegicus	93-100
24460221-3	2014	The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain.	Fatty Acids, Unsaturated	20-43	fatty acid desaturase 2	Homo sapiens	127-132
24460221-3	2014	The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain.	Fatty Acids, Unsaturated	20-43	fatty acid desaturase 3	Homo sapiens	138-143
24460221-3	2014	The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain.	Fatty Acids, Unsaturated	45-48	fatty acid desaturase 1	Homo sapiens	120-125
24460221-3	2014	The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain.	Fatty Acids, Unsaturated	45-48	fatty acid desaturase 2	Homo sapiens	127-132
24460221-3	2014	The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain.	Fatty Acids, Unsaturated	45-48	fatty acid desaturase 3	Homo sapiens	138-143
24411721-7	2014	These findings show that progesterone increases n-3 PUFA biosynthesis by up-regulating the mRNA expression of genes involved in this pathway, possibly via changes in the epigenetic regulation of FADS2.	Fatty Acids, Unsaturated	52-56	fatty acid desaturase 2	Homo sapiens	195-200
24622833-2	2014	We investigated the anti-inflammatory effect of 10-day n-3 PUFA intake (30 mg/kg/day for 10 days) on expression of Cx40 isoform in the aorta of Wistar rats injected with a single dose of lipopolysaccharide (LPS, 1 mg/kg, i.p.).	Fatty Acids, Unsaturated	59-63	gap junction protein, alpha 5	Rattus norvegicus	115-119
24368335-11	2014	Thus, our findings suggest that SAD6 functions as a Delta9-desaturase, and together with FAD3 it increases the levels of unsaturated fatty acids in crown galls under hypoxia and drought stress conditions.	Fatty Acids, Unsaturated	121-144	Plant stearoyl-acyl-carrier-protein desaturase family protein	Arabidopsis thaliana	32-36
24368335-11	2014	Thus, our findings suggest that SAD6 functions as a Delta9-desaturase, and together with FAD3 it increases the levels of unsaturated fatty acids in crown galls under hypoxia and drought stress conditions.	Fatty Acids, Unsaturated	121-144	16:0delta9 desaturase 2	Arabidopsis thaliana	52-69
24368335-11	2014	Thus, our findings suggest that SAD6 functions as a Delta9-desaturase, and together with FAD3 it increases the levels of unsaturated fatty acids in crown galls under hypoxia and drought stress conditions.	Fatty Acids, Unsaturated	121-144	fatty acid desaturase 3	Arabidopsis thaliana	89-93
24454781-11	2014	Our results provide the first evidence that an endogenous polyunsaturated fatty acid (PUFA) promotes a DNA demethylation process responsible for the activation of RAS/ERK/C/EBPbeta pathway during the monocyte differentiation commitment.	Fatty Acids, Unsaturated	58-84	mitogen-activated protein kinase 1	Homo sapiens	167-170
24465480-1	2014	Arachidonate 15-lipoxygenase-1 (ALOX15) oxygenates polyunsaturated fatty acids and bio-membranes, generating multiple lipid signalling mediators involved in inflammation.	Fatty Acids, Unsaturated	51-78	arachidonate 15-lipoxygenase	Homo sapiens	32-38
24454781-11	2014	Our results provide the first evidence that an endogenous polyunsaturated fatty acid (PUFA) promotes a DNA demethylation process responsible for the activation of RAS/ERK/C/EBPbeta pathway during the monocyte differentiation commitment.	Fatty Acids, Unsaturated	58-84	CCAAT enhancer binding protein beta	Homo sapiens	171-180
24454781-11	2014	Our results provide the first evidence that an endogenous polyunsaturated fatty acid (PUFA) promotes a DNA demethylation process responsible for the activation of RAS/ERK/C/EBPbeta pathway during the monocyte differentiation commitment.	Fatty Acids, Unsaturated	86-90	mitogen-activated protein kinase 1	Homo sapiens	167-170
24454781-11	2014	Our results provide the first evidence that an endogenous polyunsaturated fatty acid (PUFA) promotes a DNA demethylation process responsible for the activation of RAS/ERK/C/EBPbeta pathway during the monocyte differentiation commitment.	Fatty Acids, Unsaturated	86-90	CCAAT enhancer binding protein beta	Homo sapiens	171-180
24454790-1	2014	BACKGROUND: Arachidonic acid (AA; C20:4 n-6) and docosahexaenoic acid (DHA; C22:6 n-3) are important long-chain polyunsaturated fatty acids (LC-PUFA) in maintaining pancreatic beta-cell structure and function.	Fatty Acids, Unsaturated	112-139	pumilio RNA binding family member 3	Homo sapiens	144-148
24422608-8	2014	The ratio of total unsaturated fatty acids in milk fat to its daily intake was substantially lower for Diet MF compared with Diet CS, suggesting that the high proportion of roughage resulted in a high rate of biohydrogenation in the rumen.	Fatty Acids, Unsaturated	19-42	Weaning weight-maternal milk	Bos taurus	46-50
24901717-11	2014	These results suggest that polyunsaturated fatty acids (PUFAs) such as EPA have an effect on the cholesterol homeostasis in macrophages, and they can change the expression of ABCG1 gene.	Fatty Acids, Unsaturated	27-54	ATP binding cassette subfamily G member 1	Homo sapiens	175-180
24901717-11	2014	These results suggest that polyunsaturated fatty acids (PUFAs) such as EPA have an effect on the cholesterol homeostasis in macrophages, and they can change the expression of ABCG1 gene.	Fatty Acids, Unsaturated	56-61	ATP binding cassette subfamily G member 1	Homo sapiens	175-180
24664752-0	2014	Biosynthesis of very long-chain polyunsaturated fatty acids in hepatocytes expressing ELOVL4.	Fatty Acids, Unsaturated	32-59	ELOVL fatty acid elongase 4	Homo sapiens	86-92
24664752-1	2014	Elongation of Very Long chain fatty acids-4 (ELOVL4) is a fatty acid condensing enzyme that mediates biosynthesis of very long chain polyunsaturated fatty acids (VLC-PUFA; &gt;= C28) in a limited number of tissues.	Fatty Acids, Unsaturated	133-160	ELOVL fatty acid elongase 4	Homo sapiens	45-51
24664752-1	2014	Elongation of Very Long chain fatty acids-4 (ELOVL4) is a fatty acid condensing enzyme that mediates biosynthesis of very long chain polyunsaturated fatty acids (VLC-PUFA; &gt;= C28) in a limited number of tissues.	Fatty Acids, Unsaturated	133-160	pumilio RNA binding family member 3	Homo sapiens	166-170
24664753-2	2014	ELOVL4 catalyzes the initial condensation step in the elongation of polyunsaturated fatty acids (PUFA) containing more than 26 carbons (26C) to very long chain PUFA (VLC-PUFA; C28 and greater).	Fatty Acids, Unsaturated	68-95	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	0-6
24664753-2	2014	ELOVL4 catalyzes the initial condensation step in the elongation of polyunsaturated fatty acids (PUFA) containing more than 26 carbons (26C) to very long chain PUFA (VLC-PUFA; C28 and greater).	Fatty Acids, Unsaturated	97-101	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	0-6
24392920-5	2014	Both (E)-2-octenal and oct-1-en-3-ol exposure caused a shift to unsaturated fatty acids and lower cholesterol levels in the membrane.	Fatty Acids, Unsaturated	64-87	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	23-28
24561973-10	2014	Dietary unsaturated fatty acids is possibly associated with the production of a pro-coagulation factor without enhancing the secretion of pro-inflammatory molecules, while saturated fatty acids have no effect on activated plasminogen activator inhibitor 1, but their level is negatively associated with the inflammatory factor C-reactive protein.	Fatty Acids, Unsaturated	8-31	C-reactive protein	Homo sapiens	327-345
24401211-11	2014	Moreover, PUFAs treatment, compared to placebo, decreased IL-6 levels (p = 0.03) and increased PAI-1 levels (p = 0.03).	Fatty Acids, Unsaturated	10-15	interleukin 6	Homo sapiens	58-62
24401211-11	2014	Moreover, PUFAs treatment, compared to placebo, decreased IL-6 levels (p = 0.03) and increased PAI-1 levels (p = 0.03).	Fatty Acids, Unsaturated	10-15	serpin family E member 1	Homo sapiens	95-100
24771368-0	2014	Effect of polyunsaturated fatty acids omega-3 on the induction of activity and expression of CYP1A1 and CYP1A2 genes in the liver of rats under the influence of indole-3-carbinol.	Fatty Acids, Unsaturated	10-37	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	93-99
24284026-0	2014	Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure.	Fatty Acids, Unsaturated	25-51	fatty acid desaturase 2	Homo sapiens	0-18
24771368-0	2014	Effect of polyunsaturated fatty acids omega-3 on the induction of activity and expression of CYP1A1 and CYP1A2 genes in the liver of rats under the influence of indole-3-carbinol.	Fatty Acids, Unsaturated	10-37	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	104-110
24284026-5	2014	Chronic inhibition of D6D in vivo reversed similar patterns of myocardial polyunsaturated fatty acid redistribution in rat models of pressure overload and hypertensive heart disease and significantly attenuated cardiac hypertrophy, fibrosis, and contractile dysfunction in both models.	Fatty Acids, Unsaturated	74-100	fatty acid desaturase 2	Rattus norvegicus	22-25
24378641-1	2014	Delta-6-fatty acid desaturase (FADS2) is the key enzyme in the biosynthesis of polyunsaturated fatty acids (PUFAs), the essential structural determinants of mammalian membrane lipid-bilayers.	Fatty Acids, Unsaturated	79-106	fatty acid desaturase 2	Homo sapiens	0-29
24378641-1	2014	Delta-6-fatty acid desaturase (FADS2) is the key enzyme in the biosynthesis of polyunsaturated fatty acids (PUFAs), the essential structural determinants of mammalian membrane lipid-bilayers.	Fatty Acids, Unsaturated	79-106	fatty acid desaturase 2	Homo sapiens	31-36
24378641-1	2014	Delta-6-fatty acid desaturase (FADS2) is the key enzyme in the biosynthesis of polyunsaturated fatty acids (PUFAs), the essential structural determinants of mammalian membrane lipid-bilayers.	Fatty Acids, Unsaturated	108-113	fatty acid desaturase 2	Homo sapiens	0-29
24378641-1	2014	Delta-6-fatty acid desaturase (FADS2) is the key enzyme in the biosynthesis of polyunsaturated fatty acids (PUFAs), the essential structural determinants of mammalian membrane lipid-bilayers.	Fatty Acids, Unsaturated	108-113	fatty acid desaturase 2	Homo sapiens	31-36
24756710-5	2014	Together with the use of genetic mouse models, applications of these compounds have revealed not only the physiological functions but also regulatory mechanisms of TRPV3 channel by extracellular Ca(2+), Mg(2+), and protons as well as intracellular Ca(2+)-calmodulin, ATP, phosphatidylinositol 4,5-bisphosphate, polyunsaturated fatty acids, protons, and Mg(2+).	Fatty Acids, Unsaturated	311-338	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	164-169
24211519-2	2014	The results showed that Akt phosphorylation was increased in SK-Hep-1 cells treated with insulin in a time- and concentration-dependent manner, which was inhibited by saturated fatty acids, but not by unsaturated fatty acids.	Fatty Acids, Unsaturated	201-224	insulin	Homo sapiens	89-96
24919478-6	2014	The highest polyunsaturated fatty acids (PUFA) were found to be 67.14 % at the first stage of maturity (St1).	Fatty Acids, Unsaturated	12-39	syndecan binding protein	Homo sapiens	104-107
24919478-6	2014	The highest polyunsaturated fatty acids (PUFA) were found to be 67.14 % at the first stage of maturity (St1).	Fatty Acids, Unsaturated	41-45	syndecan binding protein	Homo sapiens	104-107
24489479-2	2014	Although the principal locus controlling the proportion of polyunsaturated fatty acids (PUFAs) in seeds of Arabidopsis thaliana is known (fatty acid desaturase 2; FAD2), commercial cultivars of a related crop, oilseed rape (Brassica napus), with very low PUFA content have yet to be developed.	Fatty Acids, Unsaturated	59-86	fatty acid desaturase 2	Arabidopsis thaliana	138-161
24489479-2	2014	Although the principal locus controlling the proportion of polyunsaturated fatty acids (PUFAs) in seeds of Arabidopsis thaliana is known (fatty acid desaturase 2; FAD2), commercial cultivars of a related crop, oilseed rape (Brassica napus), with very low PUFA content have yet to be developed.	Fatty Acids, Unsaturated	59-86	fatty acid desaturase 2	Arabidopsis thaliana	163-167
25059053-0	2014	[The effect of diet ratio of polyunsaturated fatty acids of omega-3 and omega-6 families on activity of aminotransferases and gamma-glutamyltransferase in rat blood serum].	Fatty Acids, Unsaturated	29-56	gamma-glutamyltransferase 1	Rattus norvegicus	126-151
24381500-8	2013	In 253J cells, the TREK2 channel was activated by polyunsaturated fatty acids, intracellular acidosis at -60 mV and mechanical stretch at -40 mV or 40 mV.	Fatty Acids, Unsaturated	50-77	potassium two pore domain channel subfamily K member 10	Homo sapiens	19-24
24128189-6	2013	Furthermore, in the presence of the very-long-chain polyunsaturated fatty acids (VLCPUFA) EPA and DHA, TAG formed by TpDGAT2 displayed three- to six-fold increases in the percentage of VLCPUFA relative to that of AtDGAT1 even though TpDGAT2 conferred much lower TAG-synthetic activities than Arabidopsis DGAT1.	Fatty Acids, Unsaturated	52-79	membrane bound O-acyl transferase (MBOAT) family protein	Arabidopsis thaliana	213-220
24128189-6	2013	Furthermore, in the presence of the very-long-chain polyunsaturated fatty acids (VLCPUFA) EPA and DHA, TAG formed by TpDGAT2 displayed three- to six-fold increases in the percentage of VLCPUFA relative to that of AtDGAT1 even though TpDGAT2 conferred much lower TAG-synthetic activities than Arabidopsis DGAT1.	Fatty Acids, Unsaturated	52-79	membrane bound O-acyl transferase (MBOAT) family protein	Arabidopsis thaliana	215-220
24029080-2	2013	FAD2 catalyzes the first step needed for the production of polyunsaturated fatty acids found in the glycerolipids of cell membranes and the triacylglycerols in seeds.	Fatty Acids, Unsaturated	59-86	omega-6 fatty acid desaturase, endoplasmic reticulum	Brassica napus	0-4
24358199-5	2013	Analysis of total saponified fatty acids revealed that the residual EWAT of Bscl2(-/-) mice contained a much higher proportion of oleic 18:1n9 acid concomitant with a lower proportion of palmitic 16:0 acid, as well as increased n3- polyunsaturated fatty acids (PUFA) remodeling.	Fatty Acids, Unsaturated	261-265	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	Mus musculus	76-81
23954331-7	2013	Hitherto, fatty acids (i.e., lipokines) and the oxidation by-products of cholesterol and polyunsaturated fatty acids, such as nonenzymatic oxysterols and reactive aldehyde species, respectively, emerge as key modulators of (pre)adipocyte signaling through Wnt/beta-catenin and MAPK pathways and potential regulators of glucose homeostasis.	Fatty Acids, Unsaturated	89-116	catenin beta 1	Homo sapiens	260-272
24244462-3	2013	In comparison to cow milk, goat milk contains greater amounts of total fat, including much higher levels of the beneficial unsaturated fatty acids.	Fatty Acids, Unsaturated	123-146	Weaning weight-maternal milk	Bos taurus	32-36
24388885-4	2013	The ratio of plasma saturated fatty acid to monounsaturated fatty acid increased, whereas the ratio of polyunsaturated fatty acids to saturated fatty acids was reduced in Apo-E4 carriers.	Fatty Acids, Unsaturated	103-130	apolipoprotein E	Homo sapiens	171-177
24307768-4	2013	In our study we performed docking studies on PUFAs and their metabolites with BDNF using MVD (Molegro Virtual Docker), this has shown that the metabolites of the PUFAs mainly LXA_4, NPD1, HDHA have shown more binding affinity towards BDNF.	Fatty Acids, Unsaturated	45-50	brain derived neurotrophic factor	Homo sapiens	78-82
24307768-4	2013	In our study we performed docking studies on PUFAs and their metabolites with BDNF using MVD (Molegro Virtual Docker), this has shown that the metabolites of the PUFAs mainly LXA_4, NPD1, HDHA have shown more binding affinity towards BDNF.	Fatty Acids, Unsaturated	45-50	brain derived neurotrophic factor	Homo sapiens	234-238
24244462-9	2013	Further functional analysis showed that over-expression of miR-103 in mammary gland epithelial cells increases transcription of genes associated with milk fat synthesis, resulting in an up-regulation of fat droplet formation, triglyceride accumulation, and the proportion of unsaturated fatty acids.	Fatty Acids, Unsaturated	275-298	microRNA 103	Capra hircus	59-66
24244462-9	2013	Further functional analysis showed that over-expression of miR-103 in mammary gland epithelial cells increases transcription of genes associated with milk fat synthesis, resulting in an up-regulation of fat droplet formation, triglyceride accumulation, and the proportion of unsaturated fatty acids.	Fatty Acids, Unsaturated	275-298	Weaning weight-maternal milk	Bos taurus	150-154
24206663-3	2013	Ligand activation of liver X receptors (LXRs) preferentially drives the incorporation of polyunsaturated fatty acids into phospholipids through induction of the remodeling enzyme Lpcat3.	Fatty Acids, Unsaturated	89-116	lysophosphatidylcholine acyltransferase 3	Homo sapiens	179-185
24195588-0	2013	LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy.	Fatty Acids, Unsaturated	28-55	insulin	Homo sapiens	90-97
24188280-12	2013	In the Nrf2-null mice the PUFA/TFA ratio decreased; conversely, the MUFA/TFA ratio increased.	Fatty Acids, Unsaturated	26-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	7-11
24273738-5	2013	The agents used to promote CYP2E1 -dependent toxicity were a polyunsaturated fatty acid, arachidonic acid (AA), buthionine sulfoximine (BSO), which depletes GSH, and CCl4, which is metabolized to the CCl3 radical.	Fatty Acids, Unsaturated	61-87	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	27-33
23971733-5	2013	Using transgenic (Tg) mice over-expressing the C. elegans fat-1 gene encoding an enzyme that converts endogenous omega-6 to omega-3 polyunsaturated fatty acids (n-3 PUFAs), we showed that fat-1 Tg mice with chronically elevated brain levels of n-3 PUFAs exhibited less brain damage and significantly improved long-term neurological performance compared to wild type littermates.	Fatty Acids, Unsaturated	165-170	Omega-3 fatty acid desaturase fat-1	Caenorhabditis elegans	58-63
23897117-0	2013	Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway.	Fatty Acids, Unsaturated	0-27	signal transducer and activator of transcription 3	Mus musculus	108-113
23897117-6	2013	The enhanced suppressive activity of MDSCs by PUFAs administration was coupled with a dramatic induction of nicotinamide adenine dinucleo- tide phosphate oxidase subunit p47(phox) and was dependent on reactive oxygen species (ROS) production.	Fatty Acids, Unsaturated	46-51	NSFL1 (p97) cofactor (p47)	Mus musculus	170-173
24057001-8	2013	First, we found that mutant livers accumulate multiple polyunsaturated fatty acids (PUFAs) and PUFA-CoAs, and we showed that human HMGCR is inhibited by PUFA-CoAs in vitro.	Fatty Acids, Unsaturated	55-82	pumilio RNA binding family member 3	Homo sapiens	84-88
24057001-8	2013	First, we found that mutant livers accumulate multiple polyunsaturated fatty acids (PUFAs) and PUFA-CoAs, and we showed that human HMGCR is inhibited by PUFA-CoAs in vitro.	Fatty Acids, Unsaturated	55-82	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	131-136
24167612-0	2013	Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children.	Fatty Acids, Unsaturated	116-142	fatty acid desaturase 1	Homo sapiens	31-36
24006511-0	2013	Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages.	Fatty Acids, Unsaturated	0-23	NLR family pyrin domain containing 3	Homo sapiens	46-51
24006511-3	2013	Here we reported opposite effects of saturated fatty acids (SFAs) compared with unsaturated fatty acids (UFAs) on NLRP3 inflammasome in human monocytes/macrophages.	Fatty Acids, Unsaturated	80-103	NLR family pyrin domain containing 3	Homo sapiens	114-119
24006511-3	2013	Here we reported opposite effects of saturated fatty acids (SFAs) compared with unsaturated fatty acids (UFAs) on NLRP3 inflammasome in human monocytes/macrophages.	Fatty Acids, Unsaturated	105-109	NLR family pyrin domain containing 3	Homo sapiens	114-119
24006511-8	2013	These results provide a new anti-inflammatory mechanism of UFAs by preventing the activation of the NLRP3 inflammasome and, therefore, IL-1beta processing.	Fatty Acids, Unsaturated	59-63	NLR family pyrin domain containing 3	Homo sapiens	100-105
24006511-8	2013	These results provide a new anti-inflammatory mechanism of UFAs by preventing the activation of the NLRP3 inflammasome and, therefore, IL-1beta processing.	Fatty Acids, Unsaturated	59-63	interleukin 1 beta	Homo sapiens	135-143
24006511-9	2013	By this way, UFAs might play a protective role in NLRP3-associated diseases.	Fatty Acids, Unsaturated	13-17	NLR family pyrin domain containing 3	Homo sapiens	50-55
24167612-0	2013	Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children.	Fatty Acids, Unsaturated	116-142	fatty acid desaturase 2	Homo sapiens	41-46
24167612-0	2013	Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children.	Fatty Acids, Unsaturated	116-142	ELOVL fatty acid elongase 5	Homo sapiens	62-68
23633519-0	2013	Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells.	Fatty Acids, Unsaturated	0-27	AKT serine/threonine kinase 1	Homo sapiens	74-77
24012277-10	2013	In conclusion, the present study demonstrates that increasing the UFA content of milk should not be a goal as such when supplementing UFA to dairy cows as higher bulk tank UFA are associated with worsened fertility results.	Fatty Acids, Unsaturated	66-69	Weaning weight-maternal milk	Bos taurus	81-85
24075747-3	2013	We investigated the involvement of the Nrf2 signaling pathway in FABP4-upregulation in response to aldehydes that are derived from polyunsaturated fatty acid (PUFA) oxidation.	Fatty Acids, Unsaturated	131-157	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
24075747-3	2013	We investigated the involvement of the Nrf2 signaling pathway in FABP4-upregulation in response to aldehydes that are derived from polyunsaturated fatty acid (PUFA) oxidation.	Fatty Acids, Unsaturated	131-157	fatty acid binding protein 4	Homo sapiens	65-70
24075747-3	2013	We investigated the involvement of the Nrf2 signaling pathway in FABP4-upregulation in response to aldehydes that are derived from polyunsaturated fatty acid (PUFA) oxidation.	Fatty Acids, Unsaturated	159-163	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
24075747-3	2013	We investigated the involvement of the Nrf2 signaling pathway in FABP4-upregulation in response to aldehydes that are derived from polyunsaturated fatty acid (PUFA) oxidation.	Fatty Acids, Unsaturated	159-163	fatty acid binding protein 4	Homo sapiens	65-70
23918045-0	2013	SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARdelta expression in mice.	Fatty Acids, Unsaturated	47-51	stearoyl-Coenzyme A desaturase 1	Mus musculus	0-4
23182924-9	2013	Children"s monounsaturated fatty acid intake (E%) correlated with apoA-I (p = 0.048) and, furthermore, there was a negative correlation between polyunsaturated fatty acid intake (E%) and apoB (p = 0.046).	Fatty Acids, Unsaturated	144-170	apolipoprotein B	Homo sapiens	187-191
24075244-1	2013	Molecular regulation of fatty acid desaturase (Fads) gene expression by dietary arachidonic acid (ARA) and docosahexaenoic acid (DHA) during early post-natal period, when the demand for long chain polyunsaturated fatty acids (LC-PUFA) is very high, has not been well defined.	Fatty Acids, Unsaturated	197-224	stearoyl-CoA desaturase	Homo sapiens	47-51
23638692-2	2013	PURPOSE: In a previous paper, we showed that chemiluminescence from radical recombination (initiated by lipid peroxidation and propagated by polyunsaturated fatty acids [PUFA]) has a bleaching effect comparable to that caused by light on the rhodopsin of retinal rod outer segment (RdOS) prepared from bovine eyes.	Fatty Acids, Unsaturated	141-168	rhodopsin	Bos taurus	242-251
23962454-10	2013	These results correlated with polyunsaturated fatty acid-rich TAG levels also increasing with mouse germ cell differentiation highest in RB, connecting DGAT2 with the biosynthesis of such TAGs.	Fatty Acids, Unsaturated	30-56	diacylglycerol O-acyltransferase 2	Mus musculus	152-157
23856367-2	2013	Lipoxygenase activity has been known to be affected by unsaturated fatty acids or phenolic compounds.	Fatty Acids, Unsaturated	55-78	linoleate 9S-lipoxygenase-4	Glycine max	0-12
23820633-1	2013	AIMS/HYPOTHESIS: Previous studies have shown that saturated fatty acids cause insulin resistance (IR) that is prevented by unsaturated fatty acids.	Fatty Acids, Unsaturated	123-146	insulin	Homo sapiens	78-85
23831098-6	2013	Pairwise comparisons between FABP4 haplotypes for significantly associated traits showed that haplotype H3 was significantly associated with 1.04 wt% lower SFA concentration, 0.079 lower SFA:UFA ratio, 0.15 wt% lower lauric acid (12:0), and 0.27 wt% lower myristic acid (14:0) concentrations, but 1.04 wt% higher UFA and 0.91 wt% higher MUFA concentrations compared with haplotype H1 during the first 3 mo of lactation.	Fatty Acids, Unsaturated	191-194	fatty acid-binding protein, adipocyte	Bos taurus	29-34
23831098-6	2013	Pairwise comparisons between FABP4 haplotypes for significantly associated traits showed that haplotype H3 was significantly associated with 1.04 wt% lower SFA concentration, 0.079 lower SFA:UFA ratio, 0.15 wt% lower lauric acid (12:0), and 0.27 wt% lower myristic acid (14:0) concentrations, but 1.04 wt% higher UFA and 0.91 wt% higher MUFA concentrations compared with haplotype H1 during the first 3 mo of lactation.	Fatty Acids, Unsaturated	313-316	fatty acid-binding protein, adipocyte	Bos taurus	29-34
23831098-10	2013	In conclusion, polymorphisms in FABP4 and SLC27A6 can be used to select for cattle producing milk with lower concentrations of SFA and higher concentrations of UFA.	Fatty Acids, Unsaturated	160-163	fatty acid-binding protein, adipocyte	Bos taurus	32-37
23831098-10	2013	In conclusion, polymorphisms in FABP4 and SLC27A6 can be used to select for cattle producing milk with lower concentrations of SFA and higher concentrations of UFA.	Fatty Acids, Unsaturated	160-163	solute carrier family 27 member 6	Bos taurus	42-49
23512934-2	2013	Both n-3 and n-6 polyunsaturated fatty acids (PUFA) regulate expression of the SCD enzymes.	Fatty Acids, Unsaturated	46-50	stearoyl-CoA desaturase	Homo sapiens	79-82
23811225-4	2013	CYP-13A12 promotes oxidation of polyunsaturated fatty acids into eicosanoids, signaling molecules that can strongly affect inflammatory pain and ischemia-reperfusion injury responses in mammals.	Fatty Acids, Unsaturated	32-59	CYtochrome P450 family	Caenorhabditis elegans	0-9
23584593-0	2013	Omega-3 polyunsaturated fatty acids increase plasma adiponectin to leptin ratio in stable coronary artery disease.	Fatty Acids, Unsaturated	8-35	adiponectin, C1Q and collagen domain containing	Homo sapiens	52-63
23584593-0	2013	Omega-3 polyunsaturated fatty acids increase plasma adiponectin to leptin ratio in stable coronary artery disease.	Fatty Acids, Unsaturated	8-35	leptin	Homo sapiens	67-73
23438101-3	2013	OBJECTIVE: To assess the effect of metformin (Met) or omega-3 (omega-3) polyunsaturated fatty acids (PUFA) on the homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, lipid profile, and body mass index (BMI) of obese children.	Fatty Acids, Unsaturated	101-105	insulin	Homo sapiens	153-160
23845737-3	2013	Before and concurrent with the onset of PAMP-triggered immunity, there are alterations in plant membrane lipid composition, modification of membrane fluidity through desaturase-mediated changes in unsaturated fatty acid levels, and enzymatic and non-enzymatic genesis of bioactive lipid mediators such as oxylipins.	Fatty Acids, Unsaturated	197-219	adrenomedullin	Homo sapiens	40-44
23720822-0	2013	UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids.	Fatty Acids, Unsaturated	74-97	Fas associated factor family member 2	Homo sapiens	14-19
23720822-0	2013	UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids.	Fatty Acids, Unsaturated	74-97	Fas associated factor 1	Homo sapiens	24-28
23720822-2	2013	Ubxd8 polymerizes upon interaction with long-chain unsaturated FAs, but the molecular mechanism involved in this polymerization remains unclear.	Fatty Acids, Unsaturated	51-66	Fas associated factor family member 2	Homo sapiens	0-5
23720822-7	2013	Long-chain unsaturated FAs also induced polymerization of Fas-associated factor 1 (FAF1), the only other mammalian protein that contains a UAS domain homologous to that of Ubxd8.	Fatty Acids, Unsaturated	11-26	Fas associated factor 1	Homo sapiens	58-81
23720822-7	2013	Long-chain unsaturated FAs also induced polymerization of Fas-associated factor 1 (FAF1), the only other mammalian protein that contains a UAS domain homologous to that of Ubxd8.	Fatty Acids, Unsaturated	11-26	Fas associated factor 1	Homo sapiens	83-87
23720822-7	2013	Long-chain unsaturated FAs also induced polymerization of Fas-associated factor 1 (FAF1), the only other mammalian protein that contains a UAS domain homologous to that of Ubxd8.	Fatty Acids, Unsaturated	11-26	Fas associated factor family member 2	Homo sapiens	172-177
23858092-2	2013	One type of PPAR, PPAR-alpha, is a transcription factor that regulates the metabolism of lipids, carbohydrates, and amino acids and is activated by ligands such as polyunsaturated fatty acids and drugs used to treat dyslipidemias.	Fatty Acids, Unsaturated	164-191	peroxisome proliferator activated receptor alpha	Homo sapiens	12-16
23685806-6	2013	Detection of a PTP1b-dependent, but functionally uncharacterized, set of phosphosites on lipid-metabolic proteins motivated global lipidomic analyses that revealed altered polyunsaturated-fatty-acid (PUFA) and triglyceride metabolism in L-PTP1b(-/-) mice.	Fatty Acids, Unsaturated	200-204	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	15-20
23886338-3	2013	This study was conducted to examine the effects of PUFA and specifically different dietary n-6: n-3 fatty acid ratios (FAR) on the number and size of hippocampal neurons and the expression of synaptophysin protein in the hippocampus of rats.	Fatty Acids, Unsaturated	51-55	synaptophysin	Rattus norvegicus	192-205
23879935-0	2013	Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members.	Fatty Acids, Unsaturated	0-26	GLI family zinc finger 2	Homo sapiens	71-76
23858092-2	2013	One type of PPAR, PPAR-alpha, is a transcription factor that regulates the metabolism of lipids, carbohydrates, and amino acids and is activated by ligands such as polyunsaturated fatty acids and drugs used to treat dyslipidemias.	Fatty Acids, Unsaturated	164-191	peroxisome proliferator activated receptor alpha	Homo sapiens	18-28
24396573-0	2013	The Effect of Unsaturated Fatty Acids on Molecular Markers of Cholesterol Homeostasis in THP-1 Macrophages.	Fatty Acids, Unsaturated	14-37	GLI family zinc finger 2	Homo sapiens	89-94
22927668-2	2013	Several lines of evidence suggest that polyunsaturated fatty acids (PUFAs) play a role in myelination, and there is substantial evidence documenting decreased PUFA concentrations in schizophrenia.	Fatty Acids, Unsaturated	39-66	pumilio RNA binding family member 3	Homo sapiens	68-72
23658423-1	2013	Marine n3 polyunsaturated fatty acids (PUFAs) activate the transcription factor peroxisome proliferator-activated receptor (PPARgamma), which modulates the expression of adiponectin.	Fatty Acids, Unsaturated	10-37	peroxisome proliferator activated receptor gamma	Homo sapiens	124-133
23658423-1	2013	Marine n3 polyunsaturated fatty acids (PUFAs) activate the transcription factor peroxisome proliferator-activated receptor (PPARgamma), which modulates the expression of adiponectin.	Fatty Acids, Unsaturated	10-37	adiponectin, C1Q and collagen domain containing	Homo sapiens	170-181
23658423-1	2013	Marine n3 polyunsaturated fatty acids (PUFAs) activate the transcription factor peroxisome proliferator-activated receptor (PPARgamma), which modulates the expression of adiponectin.	Fatty Acids, Unsaturated	39-44	peroxisome proliferator activated receptor gamma	Homo sapiens	124-133
23658423-1	2013	Marine n3 polyunsaturated fatty acids (PUFAs) activate the transcription factor peroxisome proliferator-activated receptor (PPARgamma), which modulates the expression of adiponectin.	Fatty Acids, Unsaturated	39-44	adiponectin, C1Q and collagen domain containing	Homo sapiens	170-181
23558010-7	2013	DGAT1 inhibition causes an enrichment of polyunsaturated fatty acids within the TG class of lipids.	Fatty Acids, Unsaturated	41-68	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
23826284-0	2013	Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance.	Fatty Acids, Unsaturated	0-27	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	61-67
23826284-0	2013	Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance.	Fatty Acids, Unsaturated	0-27	potassium calcium-activated channel subfamily M regulatory beta subunit 3	Homo sapiens	68-74
23826284-0	2013	Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance.	Fatty Acids, Unsaturated	0-27	insulin	Homo sapiens	96-103
23843691-0	2013	Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice.	Fatty Acids, Unsaturated	44-49	FAT atypical cadherin 1	Mus musculus	133-137
23618969-2	2013	Recent studies show that the unsaturated fatty acids can promote GLP-1 secretion from intestinal L-cells.	Fatty Acids, Unsaturated	29-52	glucagon	Mus musculus	65-70
22841393-2	2013	Recent in vitro studies suggested that curcumin and polyunsaturated fatty acids (PUFAs) also bind to VDR with low affinity.	Fatty Acids, Unsaturated	52-79	vitamin D receptor	Homo sapiens	101-104
23690440-6	2013	Lipidomics analysis revealed that PLA2G2D in the LNs contributed to mobilization of a pool of polyunsaturated fatty acids that could serve as precursors for antiinflammatory/pro-resolving lipid mediators such as resolvin D1 and 15-deoxy-Delta(12,14)-prostaglandin J2, which reduced Th1 cytokine production and surface MHC class II expression in LN cells or DCs.	Fatty Acids, Unsaturated	94-121	phospholipase A2, group IID	Mus musculus	34-41
23690440-6	2013	Lipidomics analysis revealed that PLA2G2D in the LNs contributed to mobilization of a pool of polyunsaturated fatty acids that could serve as precursors for antiinflammatory/pro-resolving lipid mediators such as resolvin D1 and 15-deoxy-Delta(12,14)-prostaglandin J2, which reduced Th1 cytokine production and surface MHC class II expression in LN cells or DCs.	Fatty Acids, Unsaturated	94-121	negative elongation factor complex member C/D, Th1l	Mus musculus	282-285
22769444-1	2013	BACKGROUND: Long-chain polyunsaturated fatty acids omega-3 and omega-6 (LC-PUFA n-3 and n-6) can function as important inflammatory modulators and also have a strong effect in the proresolving inflammatory processes.	Fatty Acids, Unsaturated	23-50	pumilio RNA binding family member 3	Homo sapiens	75-79
23524242-6	2013	Lro1p which has low fatty acid substrate specificity in vivo is the major TG synthase in this yeast, whereas Dga1p contributes less to TG synthesis although with some preference to utilize polyunsaturated fatty acids as substrates.	Fatty Acids, Unsaturated	189-216	phospholipid:diacylglycerol acyltransferase	Saccharomyces cerevisiae S288C	0-5
23524242-6	2013	Lro1p which has low fatty acid substrate specificity in vivo is the major TG synthase in this yeast, whereas Dga1p contributes less to TG synthesis although with some preference to utilize polyunsaturated fatty acids as substrates.	Fatty Acids, Unsaturated	189-216	diacylglycerol O-acyltransferase	Saccharomyces cerevisiae S288C	109-114
23434712-1	2013	Phosphatidylserine (PS) rich in polyunsaturated fatty acids of the n-3 series was obtained by enzymatic synthesis with phospholipase D (PLD) and a marine lipid extract as substrate.	Fatty Acids, Unsaturated	32-59	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-134
23434712-1	2013	Phosphatidylserine (PS) rich in polyunsaturated fatty acids of the n-3 series was obtained by enzymatic synthesis with phospholipase D (PLD) and a marine lipid extract as substrate.	Fatty Acids, Unsaturated	32-59	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	136-139
23583568-0	2013	Peroxidized unsaturated fatty acids stimulate Toll-like receptor 4 signaling in endothelial cells.	Fatty Acids, Unsaturated	12-35	toll like receptor 4	Bos taurus	46-66
23583568-1	2013	AIM: Although unsaturated fatty acids are assumed to be protective against inflammatory disorders that include a pathway involving Toll-like receptor 4 (TLR4) activation, they might actually be toxic because of their high susceptibility to lipid peroxidation.	Fatty Acids, Unsaturated	14-37	toll like receptor 4	Bos taurus	131-151
23583568-1	2013	AIM: Although unsaturated fatty acids are assumed to be protective against inflammatory disorders that include a pathway involving Toll-like receptor 4 (TLR4) activation, they might actually be toxic because of their high susceptibility to lipid peroxidation.	Fatty Acids, Unsaturated	14-37	toll like receptor 4	Bos taurus	153-157
23583568-2	2013	Here we studied the effects of peroxidized unsaturated fatty acids on the TLR4-nuclear factor (NF)-kappaB pathway in endothelial cells.	Fatty Acids, Unsaturated	43-66	toll like receptor 4	Bos taurus	74-78
23583568-6	2013	KEY FINDINGS: In the same way as LPS, application of sufficiently peroxidized unsaturated fatty acids like oleic acid or docosahexaenoic acid, acutely caused TLR4 translocation to caveolae/raft membranes, leading to activation of NF-kappaB signaling in endothelial cells.	Fatty Acids, Unsaturated	78-101	toll like receptor 4	Bos taurus	158-162
23583568-8	2013	Applying well-peroxidized unsaturated fatty acids, but not saturated fatty acids, acutely activates the TLR4/NF-kappaB pathway.	Fatty Acids, Unsaturated	26-49	toll like receptor 4	Bos taurus	104-108
23583568-9	2013	SIGNIFICANCE: Peroxidation of unsaturated fatty acid is essential for the acute activation of TLR4 by the fatty acids that follow the same pathway as the activation by LPS.	Fatty Acids, Unsaturated	30-52	toll like receptor 4	Bos taurus	94-98
23583568-11	2013	Our result suggests that, for inflammatory disorders involving TLR4 signaling, using unsaturated fatty acids as anti-inflammatory drugs may cause contrary effects.	Fatty Acids, Unsaturated	85-108	toll like receptor 4	Bos taurus	63-67
23699409-3	2013	Here we report that constitutive mammalian target of rapamycin complex 1 (mTORC1) activity renders hypoxic cells dependent on exogenous desaturated lipids, as levels of de novo synthesized unsaturated fatty acids are reduced under low O2.	Fatty Acids, Unsaturated	189-212	CREB regulated transcription coactivator 1	Mus musculus	74-80
23671633-1	2013	BACKGROUND: Combined treatment (CT) with statins and polyunsaturated fatty acids (n-3 PUFA) resulted in a reduction of death and major cardiovascular events when administered after a myocardial infarction (MI).	Fatty Acids, Unsaturated	53-80	pumilio RNA binding family member 3	Homo sapiens	86-90
23426968-2	2013	Since n-3 polyunsaturated fatty acids (PUFA), specifically docosahexaenoic acid (DHA), alter EGFR signaling and suppress downstream activation of key signaling pathways, we hypothesized that DHA would be detrimental to the process of intestinal wound healing.	Fatty Acids, Unsaturated	39-43	epidermal growth factor receptor	Mus musculus	93-97
22841393-2	2013	Recent in vitro studies suggested that curcumin and polyunsaturated fatty acids (PUFAs) also bind to VDR with low affinity.	Fatty Acids, Unsaturated	81-86	vitamin D receptor	Homo sapiens	101-104
23614006-10	2013	Interactions between early life stress and n-3 PUFAs deficiency were found in plasma insulin (p = 0.033), HOMA index (p = 0.049), leptin (p = 0.010) and liver PEPCK expression (p = 0.050), in which the metabolic vulnerability in the MS group was aggravated by the n-3 PUFAs deficient diet exposure.	Fatty Acids, Unsaturated	47-52	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	159-164
23698760-0	2013	The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells.	Fatty Acids, Unsaturated	17-44	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	52-67
23698760-1	2013	The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD) trafficking and activity in mast cells was investigated.	Fatty Acids, Unsaturated	42-46	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	67-82
23698760-1	2013	The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD) trafficking and activity in mast cells was investigated.	Fatty Acids, Unsaturated	42-46	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-87
23031353-10	2013	Increased proportions of C18:2 n-6 and polyunsaturated FA (PUFA) were found in LR x LW pigs, irrespective of the stage of growth and back-fat layer (P&lt;=0.02).	Fatty Acids, Unsaturated	39-57	Polyunsaturated fatty acid percentage	Sus scrofa	59-63
23370677-7	2013	GLP-2 secretion was enhanced by polyunsaturated fatty acid- and monounsaturated fatty acid-rich dietary oils, dietary carbohydrates, and some kinds of sweeteners in rats; this effect was reproduced in NCI-H716 cells using alpha-linolenic acid (alphaLA), glucose, and sweeteners.	Fatty Acids, Unsaturated	32-58	mast cell protease 10	Rattus norvegicus	0-5
23559003-1	2013	12/15-Lipoxygenase (12/15-LO) is an enzyme that converts polyunsaturated fatty acids into bioactive lipid derivatives.	Fatty Acids, Unsaturated	57-84	arachidonate 15-lipoxygenase	Mus musculus	0-18
23594480-3	2013	Long-chain omega-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects, and the G protein-coupled receptor GPR120 was reported to mediate the anti-inflammatory effects of omega-3 PUFAs.	Fatty Acids, Unsaturated	48-52	free fatty acid receptor 4	Homo sapiens	121-127
23270816-2	2013	Saccharomyces cerevisiae coq1-coq9 mutants have defects in Q biosynthesis, lack Q6, are respiratory defective, and sensitive to stress imposed by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	146-173	trans-hexaprenyltranstransferase	Saccharomyces cerevisiae S288C	25-29
23270816-2	2013	Saccharomyces cerevisiae coq1-coq9 mutants have defects in Q biosynthesis, lack Q6, are respiratory defective, and sensitive to stress imposed by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	146-173	ubiquinone biosynthesis protein COQ9	Saccharomyces cerevisiae S288C	30-34
23479632-2	2013	Its protein product, ELOVL4, is an elongase required for the biosynthesis of very long-chain polyunsaturated fatty acids (VLC-PUFAs).	Fatty Acids, Unsaturated	93-120	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	21-27
23403031-9	2013	The ERAD of Insig-1 in S2 cells mimics the reaction that occurs in mammalian cells with regard to its inhibition by either sterols or unsaturated fatty acids.	Fatty Acids, Unsaturated	134-157	insulin induced gene 1	Homo sapiens	12-19
23395327-8	2013	Also, selective activation of phospholipase A2, which primarily releases polyunsaturated fatty acids, might not be characteristic to cell death in CA1.	Fatty Acids, Unsaturated	73-100	phospholipase A2 group IB	Rattus norvegicus	30-46
22903185-7	2013	In the nervous system, iPLA2beta is especially important for the turnover of polyunsaturated fatty acid-associated phospholipid at synapses.	Fatty Acids, Unsaturated	77-103	phospholipase A2 group VI	Homo sapiens	23-32
23319744-9	2013	In accordance, incubation of rat hepatoma cells with the polyunsaturated fatty acid C22:6 increased ANGPTL4 expression by 70-fold, compared with 27-fold by the polyunsaturated fatty acid C18:2, and 15-fold by the monounsaturated fatty acid C18:1.	Fatty Acids, Unsaturated	57-83	angiopoietin-like 4	Rattus norvegicus	100-107
23463959-4	2013	Unsaturated fatty acids and their anti-inflammatory products, such as lipoxins, resolvins, and protectins, may suppress A-FABP expression, inhibit macrophage and COX-2 activation, and decrease production of pro-inflammatory cytokines and ultimately could lead to a decrease in insulin resistance and resolution of inflammation and recovery from sepsis.	Fatty Acids, Unsaturated	0-23	fatty acid binding protein 4	Homo sapiens	120-126
23463959-4	2013	Unsaturated fatty acids and their anti-inflammatory products, such as lipoxins, resolvins, and protectins, may suppress A-FABP expression, inhibit macrophage and COX-2 activation, and decrease production of pro-inflammatory cytokines and ultimately could lead to a decrease in insulin resistance and resolution of inflammation and recovery from sepsis.	Fatty Acids, Unsaturated	0-23	prostaglandin-endoperoxide synthase 2	Homo sapiens	162-167
23261534-5	2013	There was a trend towards a positive relationship between FAS and Delta6d protein expression and saturated and polyunsaturated fatty acids content respectively, in subcutaneous fat but not in muscle.	Fatty Acids, Unsaturated	111-138	fatty acid synthase	Sus scrofa	58-61
26064833-5	2013	Recently, the fat-1 transgenic mice capable of converting n-6 to n-3 polyunsaturated fatty acids (PUFAs) have been used to examine the effects of endogenous n-3 PUFAs on NAFLD.	Fatty Acids, Unsaturated	98-103	FAT atypical cadherin 1	Mus musculus	14-19
23404690-7	2013	Intake of polyunsaturated fatty acids were negatively associated with SCD-16 (partial r = -0.30) and SCD-18 (partial r = -0.24) (P &lt; 0.001 for both).	Fatty Acids, Unsaturated	10-37	stearoyl-CoA desaturase	Homo sapiens	70-73
23353549-7	2013	Additionally, the idh1,2 disrupted strains expressing acl mainly accumulated unsaturated fatty acids.	Fatty Acids, Unsaturated	77-100	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	18-22
23404690-7	2013	Intake of polyunsaturated fatty acids were negatively associated with SCD-16 (partial r = -0.30) and SCD-18 (partial r = -0.24) (P &lt; 0.001 for both).	Fatty Acids, Unsaturated	10-37	stearoyl-CoA desaturase	Homo sapiens	101-104
23079583-7	2013	PUFA supplementation of L6 cells led to an increase in myogenic differentiation correlated to an incorporation of added PUFAs in TM and DRM glycerophospholipids.	Fatty Acids, Unsaturated	120-125	pumilio RNA binding family member 3	Homo sapiens	0-4
23357423-1	2013	Delta6-fatty acid desaturase is an important enzyme in the catalytic synthesis of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	82-109	fatty acid desaturase 2	Homo sapiens	0-28
23238934-0	2013	Impact of L-FABP and glucose on polyunsaturated fatty acid induction of PPARalpha-regulated beta-oxidative enzymes.	Fatty Acids, Unsaturated	32-58	peroxisome proliferator activated receptor alpha	Mus musculus	72-81
23055198-1	2013	15-Lipoxygenase-1 (15-Lox-1) is a key enzyme mediating oxidative metabolism of polyunsaturated fatty acids and has attracted considerable interest as a potential target for the induction of apoptosis in cancer cells.	Fatty Acids, Unsaturated	79-106	arachidonate 15-lipoxygenase	Homo sapiens	0-17
23055198-1	2013	15-Lipoxygenase-1 (15-Lox-1) is a key enzyme mediating oxidative metabolism of polyunsaturated fatty acids and has attracted considerable interest as a potential target for the induction of apoptosis in cancer cells.	Fatty Acids, Unsaturated	79-106	arachidonate 15-lipoxygenase	Homo sapiens	19-27
23265344-1	2013	OBJECTIVES: The aim of this study was to evaluate the efficacy of polyunsaturated fatty acids (n-3 PUFA) for the prevention of recurrent atrial fibrillation (AF) in patients with normal sinus rhythm.	Fatty Acids, Unsaturated	66-93	pumilio RNA binding family member 3	Homo sapiens	99-103
23297776-3	2013	Among the most predominant sources of off-flavors in SPI is the residual amount of phospholipids that contain polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	110-137	chromogranin A	Homo sapiens	53-56
23302442-1	2013	Epidemiological studies have demonstrated the benefits of nut consumption on cardiovascular risk factors and CHD, attributed to their fatty acid profile, rich in unsaturated fatty acids, and also to other nutrients.	Fatty Acids, Unsaturated	162-185	NUT midline carcinoma, family member 1	Mus musculus	58-61
22997156-10	2013	CONCLUSION: Some oxidized derivatives of polyunsaturated fatty acids contained in TANC of human carotid plaques are strong inducers of Adam17, which in turn leads to the generation of sMer, which can inhibit efferocytosis.	Fatty Acids, Unsaturated	41-68	ADAM metallopeptidase domain 17	Homo sapiens	135-141
24469870-1	2013	BACKGROUND: We aimed to prospectively assess the influence of the recommended dose, 1.0 g of polyunsaturated fatty acids (N-3 PUFA) daily, on platelet reactivity in patients with stable angina pectoris (SAP) after elective percutaneous coronary intervention (PCI).	Fatty Acids, Unsaturated	93-120	pumilio RNA binding family member 3	Homo sapiens	126-130
23224081-1	2013	Cytochrome P450 (CYP) epoxygenases metabolize endogenous polyunsaturated fatty acids to their corresponding epoxides, generating bioactive lipid mediators.	Fatty Acids, Unsaturated	57-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
23224081-1	2013	Cytochrome P450 (CYP) epoxygenases metabolize endogenous polyunsaturated fatty acids to their corresponding epoxides, generating bioactive lipid mediators.	Fatty Acids, Unsaturated	57-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
23691291-4	2013	Palmitate and stearate increased the expression of PTEN, whereas the unsaturated fatty acids, oleate and linoleate, reduced PTEN expression in both cell types.	Fatty Acids, Unsaturated	69-92	phosphatase and tensin homolog	Homo sapiens	124-128
23159066-9	2013	In ovariectomized rats, treatment with n-3 PUFA increased n-3 PUFA total content and omega-3 index and decreased n-6:n-3 PUFA ratio in erythrocyte membrane, reversed vascular oxidative stress, endothelial dysfunction, aortic 3-nitrotyrosine and markedly lowered NOX-4 protein expression; eNOS protein expression also increased, paralleled by reversal of inhibitory binding to Caveolin-1, while ex-vivo functional inhibition and NOS synthesis were unchanged.	Fatty Acids, Unsaturated	43-47	NADPH oxidase 4	Rattus norvegicus	262-267
23159066-9	2013	In ovariectomized rats, treatment with n-3 PUFA increased n-3 PUFA total content and omega-3 index and decreased n-6:n-3 PUFA ratio in erythrocyte membrane, reversed vascular oxidative stress, endothelial dysfunction, aortic 3-nitrotyrosine and markedly lowered NOX-4 protein expression; eNOS protein expression also increased, paralleled by reversal of inhibitory binding to Caveolin-1, while ex-vivo functional inhibition and NOS synthesis were unchanged.	Fatty Acids, Unsaturated	43-47	caveolin 1	Rattus norvegicus	376-386
24008613-0	2013	The generation of transgenic mice with fat1 and fad2 genes that have their own polyunsaturated fatty acid biosynthetic pathway.	Fatty Acids, Unsaturated	79-105	FAT atypical cadherin 1	Mus musculus	39-43
23818766-1	2013	BACKGROUND: To investigate the association of FADS gene polymorphisms with age-related changes in polyunsaturated fatty acids (PUFAs) in serum phospholipids and oxidative stress markers.	Fatty Acids, Unsaturated	98-125	muscle associated receptor tyrosine kinase	Homo sapiens	46-50
23818766-1	2013	BACKGROUND: To investigate the association of FADS gene polymorphisms with age-related changes in polyunsaturated fatty acids (PUFAs) in serum phospholipids and oxidative stress markers.	Fatty Acids, Unsaturated	127-132	muscle associated receptor tyrosine kinase	Homo sapiens	46-50
22806626-5	2012	Ces1/Es-x deficiency prevents the release of polyunsaturated fatty acids from triacylglycerol stores, leading to an up-regulation of sterol regulatory element binding protein 1c-mediated lipogenesis, which can be reversed with dietary omega-3 fatty acids.	Fatty Acids, Unsaturated	45-72	carboxylesterase 1G	Mus musculus	0-4
23234408-5	2013	The switch from SAFA diet to PUFA diet produced a significant change of CRP (C-reactive protein) concentration (p&lt;0.01) whereas similar trend of IL-18 did not reach statistical significance.	Fatty Acids, Unsaturated	29-33	C-reactive protein	Homo sapiens	72-75
23234408-5	2013	The switch from SAFA diet to PUFA diet produced a significant change of CRP (C-reactive protein) concentration (p&lt;0.01) whereas similar trend of IL-18 did not reach statistical significance.	Fatty Acids, Unsaturated	29-33	C-reactive protein	Homo sapiens	77-95
24068966-3	2013	We then show genetic evidence that paqr-2, phosphatidylcholines, sbp-1 and Delta9-desaturases form a cold adaptation pathway that regulates the increase in unsaturated fatty acids necessary to retain membrane fluidity at low temperatures.	Fatty Acids, Unsaturated	156-179	Progestin and AdipoQ Receptor family	Caenorhabditis elegans	35-41
24068966-3	2013	We then show genetic evidence that paqr-2, phosphatidylcholines, sbp-1 and Delta9-desaturases form a cold adaptation pathway that regulates the increase in unsaturated fatty acids necessary to retain membrane fluidity at low temperatures.	Fatty Acids, Unsaturated	156-179	BHLH domain-containing protein	Caenorhabditis elegans	65-70
22377337-2	2012	Rumen protozoa are rich in unsaturated fatty acids due to engulfment of PUFA-rich chloroplasts.	Fatty Acids, Unsaturated	27-50	pumilio RNA binding family member 3	Homo sapiens	72-76
22677359-6	2013	Lipoxins, resolvins, and protectins derived from various polyunsaturated fatty acids possess anti-inflammatory actions and suppress the production of interleukin-6, and TNF-alpha and VEGF have antiangiogenic actions.	Fatty Acids, Unsaturated	57-84	interleukin 6	Homo sapiens	150-163
22677359-6	2013	Lipoxins, resolvins, and protectins derived from various polyunsaturated fatty acids possess anti-inflammatory actions and suppress the production of interleukin-6, and TNF-alpha and VEGF have antiangiogenic actions.	Fatty Acids, Unsaturated	57-84	vascular endothelial growth factor A	Homo sapiens	183-187
23555925-1	2013	Brain fatty acid-binding protein (B-FABP) interacts with biological membranes and delivers polyunsaturated fatty acids (FAs) via a collisional mechanism.	Fatty Acids, Unsaturated	91-118	fatty acid binding protein 7	Homo sapiens	0-32
23555925-1	2013	Brain fatty acid-binding protein (B-FABP) interacts with biological membranes and delivers polyunsaturated fatty acids (FAs) via a collisional mechanism.	Fatty Acids, Unsaturated	91-118	fatty acid binding protein 7	Homo sapiens	34-40
23400918-6	2013	Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells which express CYP2E1 (E47 cells) but not control C34HepG2 cells which do not express CYP2E1.Toxicity was associated with enhanced oxidant stress and could be prevented by antioxidants and potentiated if glutathione (GSH) was removed.	Fatty Acids, Unsaturated	9-36	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	90-96
23258338-5	2012	Polyunsaturated fatty acids down-regulates NPC1L1 expression by the way of sterol regulatory element binding protein 2 (SREBP2).	Fatty Acids, Unsaturated	0-27	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	43-49
23258338-5	2012	Polyunsaturated fatty acids down-regulates NPC1L1 expression by the way of sterol regulatory element binding protein 2 (SREBP2).	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 2	Homo sapiens	75-118
23258338-5	2012	Polyunsaturated fatty acids down-regulates NPC1L1 expression by the way of sterol regulatory element binding protein 2 (SREBP2).	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 2	Homo sapiens	120-126
22921758-5	2012	The gas-chromatographic (GC) analysis of saturated/unsaturated fatty acids" release patterns from intact mitochondrial and erythrocyte membranes after the addition of RVVA-PLA2-I showed a distinctly different result.	Fatty Acids, Unsaturated	51-74	phospholipase A2, group V	Mus musculus	172-176
22932756-5	2012	The lpcat1/lpcat2 mutant showed increased contents of very-long-chain fatty acids and decreased PUFA in TAG and the accumulation of small amounts of lysophosphatidylcholine in developing seeds revealed by [14C]acetate-labeling experiments.	Fatty Acids, Unsaturated	96-100	MBOAT (membrane bound O-acyl transferase) family protein	Arabidopsis thaliana	4-10
22475809-3	2012	Here, we determined differential effects of eicosapentaenoic acid (EPA, n-3 PUFA) vs. arachidonic acid (AA, n-6 PUFA) on expression and secretion of angiotensinogen (Agt), interleukin 6 (IL-6) and monocyte chemotactic protein (MCP-1) in 3T3-L1 adipocytes.	Fatty Acids, Unsaturated	76-80	angiotensinogen	Homo sapiens	149-164
22955034-1	2012	The synthesis of polyunsaturated fatty acids (PUFAs), the most abundant fatty acids in plants, begins with a reaction catalyzed by fatty acid desaturase 2 (FAD2; EC 1.3.1.35), also called microsomal oleate Delta12-desaturase.	Fatty Acids, Unsaturated	17-44	fatty acid desaturase 2	Arabidopsis thaliana	156-160
22955034-1	2012	The synthesis of polyunsaturated fatty acids (PUFAs), the most abundant fatty acids in plants, begins with a reaction catalyzed by fatty acid desaturase 2 (FAD2; EC 1.3.1.35), also called microsomal oleate Delta12-desaturase.	Fatty Acids, Unsaturated	46-51	fatty acid desaturase 2	Arabidopsis thaliana	156-160
22932756-5	2012	The lpcat1/lpcat2 mutant showed increased contents of very-long-chain fatty acids and decreased PUFA in TAG and the accumulation of small amounts of lysophosphatidylcholine in developing seeds revealed by [14C]acetate-labeling experiments.	Fatty Acids, Unsaturated	96-100	MBOAT (membrane bound O-acyl transferase) family protein	Arabidopsis thaliana	11-17
23961369-4	2012	We showed the loss of pigmentation in MALME-3M cells treated with albumin-associated lipids, based on electron microscopic analysis, and the overexpression of perilipin 2 (PLIN2) by western blotting in MALME-3M and MCF-7 cells treated with unsaturated fatty acids.	Fatty Acids, Unsaturated	240-263	perilipin 2	Homo sapiens	159-170
23039070-1	2012	The aim was to determine the relative role of each of the lactogenic hormones (insulin, prolactin and hydrocortisol) and their combinations in regulating elongation and desaturation of polyunsaturated fatty acids and subsequently on composition of cellular lipid compartments in mammary epithelia.	Fatty Acids, Unsaturated	185-212	insulin	Homo sapiens	79-86
23961369-4	2012	We showed the loss of pigmentation in MALME-3M cells treated with albumin-associated lipids, based on electron microscopic analysis, and the overexpression of perilipin 2 (PLIN2) by western blotting in MALME-3M and MCF-7 cells treated with unsaturated fatty acids.	Fatty Acids, Unsaturated	240-263	perilipin 2	Homo sapiens	172-177
22913587-7	2012	Moreover, we show here that purified recombinant PXG4 is an efficient fatty acid epoxygenase, catalyzing the oxidation of cis double bonds of unsaturated fatty acids.	Fatty Acids, Unsaturated	142-165	Caleosin-related family protein	Arabidopsis thaliana	49-53
22314192-5	2012	Various treatments successful at improving insulin response (thiazolidinediones (TZDs), n-3 polyunsaturated fatty acid (PUFA) supplementation) also stimulate adiponectin production.	Fatty Acids, Unsaturated	120-124	insulin	Homo sapiens	43-50
22314192-5	2012	Various treatments successful at improving insulin response (thiazolidinediones (TZDs), n-3 polyunsaturated fatty acid (PUFA) supplementation) also stimulate adiponectin production.	Fatty Acids, Unsaturated	120-124	adiponectin, C1Q and collagen domain containing	Homo sapiens	158-169
22782973-1	2012	Mitochondrial enoyl-CoA isomerase (ECI1) is an auxiliary enzyme involved in unsaturated fatty acid oxidation.	Fatty Acids, Unsaturated	76-98	enoyl-Coenzyme A delta isomerase 1	Mus musculus	35-39
22782973-7	2012	Knockdown of Eci2 in Eci1-deficient fibroblasts caused a more pronounced accumulation of C12:1 acylcarnitine on incubation with unsaturated fatty acids (12-fold, P&lt;0.05).	Fatty Acids, Unsaturated	128-151	enoyl-Coenzyme A delta isomerase 2	Mus musculus	13-17
22913587-9	2012	An important regioselectivity was observed; the C-12,13 double bond of these unsaturated fatty acids being the least favored unsaturation epoxidized by PXG4, linolenic acid preferentially yielded the 9,10-15,16-diepoxide.	Fatty Acids, Unsaturated	77-100	Caleosin-related family protein	Arabidopsis thaliana	152-156
22209005-5	2012	Unsaturated FA, but not saturated FA, significantly reduced ABCA1 and ABCG1 mRNA without the agonist.	Fatty Acids, Unsaturated	0-14	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	60-65
22209005-5	2012	Unsaturated FA, but not saturated FA, significantly reduced ABCA1 and ABCG1 mRNA without the agonist.	Fatty Acids, Unsaturated	0-14	ATP binding cassette subfamily G member 1	Mus musculus	70-75
22690709-7	2012	Increased expression of ERLIN2 promotes the accumulation of cytosolic lipid droplets in breast cancer cells or hepatoma cells in response to insulin or overload of unsaturated fatty acids.	Fatty Acids, Unsaturated	164-187	ER lipid raft associated 2	Homo sapiens	24-30
22772592-6	2012	Recombinant reconstituted CYP4V2 protein metabolized eicosapentaenoic acid and docosahexaenoic acid (an important constituent of the retina) to their respective omega-hydroxylated products at rates similar to those observed with purified CYP4F2, which is an established hepatic polyunsaturated fatty acid (PUFA) hydroxylase.	Fatty Acids, Unsaturated	278-304	cytochrome P450 family 4 subfamily V member 2	Homo sapiens	26-32
22943296-4	2012	RESULTS: Inferring from molecular docking studies, lipoxin A4 (LXA4), and a known anti-inflammatory bioactive metabolite derived from PUFAs, with a binding energy of -3.98 Kcal/mol and dissociation constant of 1.2 mM showed highest binding affinity for BDNF in comparison to other PUFAs and metabolites considered in the study.	Fatty Acids, Unsaturated	134-139	brain derived neurotrophic factor	Homo sapiens	253-257
22989138-5	2012	RESULTS: Decreasing dietary n-6: n-3 PUFA ratios improved the cognitive performance of animals in the Morris water maze test along with the upregulation of PPARalpha and PPARgamma gene expression.	Fatty Acids, Unsaturated	37-41	peroxisome proliferator activated receptor alpha	Rattus norvegicus	156-165
22989138-5	2012	RESULTS: Decreasing dietary n-6: n-3 PUFA ratios improved the cognitive performance of animals in the Morris water maze test along with the upregulation of PPARalpha and PPARgamma gene expression.	Fatty Acids, Unsaturated	37-41	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	170-179
22943296-0	2012	Agonistic effect of polyunsaturated fatty acids (PUFAs) and its metabolites on brain-derived neurotrophic factor (BDNF) through molecular docking simulation.	Fatty Acids, Unsaturated	20-47	brain derived neurotrophic factor	Homo sapiens	79-112
22105830-9	2012	Both unsaturated fatty acids induced MSC to increase secretion of interleukin-6, VEGF and nitric oxide.	Fatty Acids, Unsaturated	5-28	interleukin 6	Homo sapiens	66-79
22943296-0	2012	Agonistic effect of polyunsaturated fatty acids (PUFAs) and its metabolites on brain-derived neurotrophic factor (BDNF) through molecular docking simulation.	Fatty Acids, Unsaturated	20-47	brain derived neurotrophic factor	Homo sapiens	114-118
22943296-0	2012	Agonistic effect of polyunsaturated fatty acids (PUFAs) and its metabolites on brain-derived neurotrophic factor (BDNF) through molecular docking simulation.	Fatty Acids, Unsaturated	49-54	brain derived neurotrophic factor	Homo sapiens	79-112
22943296-0	2012	Agonistic effect of polyunsaturated fatty acids (PUFAs) and its metabolites on brain-derived neurotrophic factor (BDNF) through molecular docking simulation.	Fatty Acids, Unsaturated	49-54	brain derived neurotrophic factor	Homo sapiens	114-118
22943296-2	2012	Polyunsaturated fatty acids (PUFAs) localised in cell membranes have been shown to alter the levels of BDNF in the brain, suggesting that PUFAs and BDNF could have physical interaction with each other.	Fatty Acids, Unsaturated	0-27	brain derived neurotrophic factor	Homo sapiens	103-107
22943296-2	2012	Polyunsaturated fatty acids (PUFAs) localised in cell membranes have been shown to alter the levels of BDNF in the brain, suggesting that PUFAs and BDNF could have physical interaction with each other.	Fatty Acids, Unsaturated	0-27	brain derived neurotrophic factor	Homo sapiens	148-152
22943296-3	2012	To decipher the molecular mechanism through which PUFAs modulates BDNF"s activity, molecular docking was performed for BDNF with PUFAs and its metabolites, with 4-Methyl Catechol as a control.	Fatty Acids, Unsaturated	50-55	brain derived neurotrophic factor	Homo sapiens	66-70
22943296-3	2012	To decipher the molecular mechanism through which PUFAs modulates BDNF"s activity, molecular docking was performed for BDNF with PUFAs and its metabolites, with 4-Methyl Catechol as a control.	Fatty Acids, Unsaturated	50-55	brain derived neurotrophic factor	Homo sapiens	119-123
22943296-3	2012	To decipher the molecular mechanism through which PUFAs modulates BDNF"s activity, molecular docking was performed for BDNF with PUFAs and its metabolites, with 4-Methyl Catechol as a control.	Fatty Acids, Unsaturated	129-134	brain derived neurotrophic factor	Homo sapiens	66-70
22943296-3	2012	To decipher the molecular mechanism through which PUFAs modulates BDNF"s activity, molecular docking was performed for BDNF with PUFAs and its metabolites, with 4-Methyl Catechol as a control.	Fatty Acids, Unsaturated	129-134	brain derived neurotrophic factor	Homo sapiens	119-123
22626869-8	2012	LXR mRNA expression was regulated by unsaturated fatty acids, insulin, TNFalpha and GH in isolated adipocytes.	Fatty Acids, Unsaturated	37-60	oxysterols receptor LXR-alpha	Oncorhynchus mykiss	0-3
22809447-11	2012	The PUFA group showed the lowest amount of the anti-inflammatory marker IL-10 compared to TRANS and SAFA groups.	Fatty Acids, Unsaturated	4-8	interleukin 10	Mus musculus	72-77
22862955-0	2012	Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans.	Fatty Acids, Unsaturated	49-76	Lysophospholipid acyltransferase 7	Caenorhabditis elegans	13-19
22105830-9	2012	Both unsaturated fatty acids induced MSC to increase secretion of interleukin-6, VEGF and nitric oxide.	Fatty Acids, Unsaturated	5-28	vascular endothelial growth factor A	Homo sapiens	81-85
22683933-5	2012	PA augmented TNF-alpha-induced cytotoxicity, while the unsaturated fatty acids attenuated TNF-alpha-induced cytotoxicity.	Fatty Acids, Unsaturated	55-78	tumor necrosis factor	Homo sapiens	90-99
22745130-10	2012	Unlike mDCR, hinge movements permit pDCR to process very long chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	68-95	2,4-dienoyl-CoA reductase 2	Homo sapiens	36-40
22822908-1	2012	Cyclooxygenase-2 (COX-2) is overexpressed in many human cancers and converts the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid to prostaglandin E(2) (PGE(2)), which drives tumorigenesis; in contrast, n-3 PUFA inhibit tumorigenesis.	Fatty Acids, Unsaturated	113-117	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
22822908-1	2012	Cyclooxygenase-2 (COX-2) is overexpressed in many human cancers and converts the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid to prostaglandin E(2) (PGE(2)), which drives tumorigenesis; in contrast, n-3 PUFA inhibit tumorigenesis.	Fatty Acids, Unsaturated	113-117	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
22634102-12	2012	These discoveries are consistent with the notion that LXRalpha plays a key role in controlling lipogenesis and regulating synthesis of unsaturated fatty acids (UFA) in the mammary gland of goats, which may prove useful in regulation of milk fat production.	Fatty Acids, Unsaturated	135-158	nuclear receptor subfamily 1 group H member 3	Homo sapiens	54-62
22634102-12	2012	These discoveries are consistent with the notion that LXRalpha plays a key role in controlling lipogenesis and regulating synthesis of unsaturated fatty acids (UFA) in the mammary gland of goats, which may prove useful in regulation of milk fat production.	Fatty Acids, Unsaturated	160-163	nuclear receptor subfamily 1 group H member 3	Homo sapiens	54-62
22051448-9	2012	The high n-3 PUFA diet resulted in greater mRNA levels of EC synthesis enzymes, and CB1 and CB2.	Fatty Acids, Unsaturated	13-17	cannabinoid receptor 1 (brain)	Mus musculus	84-87
22803604-3	2012	Recently, polymorphisms of the human Delta-5 (fatty acid desaturase, FADS1) and Delta-6 (FADS2) desaturase genes have been described as being associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.	Fatty Acids, Unsaturated	202-229	stearoyl-CoA desaturase	Homo sapiens	37-67
22803604-3	2012	Recently, polymorphisms of the human Delta-5 (fatty acid desaturase, FADS1) and Delta-6 (FADS2) desaturase genes have been described as being associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.	Fatty Acids, Unsaturated	202-229	fatty acid desaturase 1	Homo sapiens	69-74
22803604-3	2012	Recently, polymorphisms of the human Delta-5 (fatty acid desaturase, FADS1) and Delta-6 (FADS2) desaturase genes have been described as being associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.	Fatty Acids, Unsaturated	202-229	fatty acid desaturase 2	Homo sapiens	89-94
22803604-3	2012	Recently, polymorphisms of the human Delta-5 (fatty acid desaturase, FADS1) and Delta-6 (FADS2) desaturase genes have been described as being associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.	Fatty Acids, Unsaturated	231-236	stearoyl-CoA desaturase	Homo sapiens	37-67
22803604-3	2012	Recently, polymorphisms of the human Delta-5 (fatty acid desaturase, FADS1) and Delta-6 (FADS2) desaturase genes have been described as being associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.	Fatty Acids, Unsaturated	231-236	fatty acid desaturase 1	Homo sapiens	69-74
22803604-3	2012	Recently, polymorphisms of the human Delta-5 (fatty acid desaturase, FADS1) and Delta-6 (FADS2) desaturase genes have been described as being associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.	Fatty Acids, Unsaturated	231-236	fatty acid desaturase 2	Homo sapiens	89-94
22634396-3	2012	Rod outer segments of photoreceptors are characterized by rhodopsin, a membrane protein surrounded by phospholipids containing a very high concentration of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	156-183	rhodopsin	Bos taurus	58-67
22051448-9	2012	The high n-3 PUFA diet resulted in greater mRNA levels of EC synthesis enzymes, and CB1 and CB2.	Fatty Acids, Unsaturated	13-17	cannabinoid receptor 2 (macrophage)	Mus musculus	92-95
22538404-2	2012	Since diets rich in polyunsaturated fatty acids are a requirement for the development of alcoholic liver disease, we hypothesized that polyunsaturated fatty acids could synergize with ethanol to promote Kupffer cell activation and TNFalpha production, hence, contributing to liver injury.	Fatty Acids, Unsaturated	135-162	tumor necrosis factor	Rattus norvegicus	231-239
22661717-4	2012	The effects of bile acids were additive with the effects of nonesterified unsaturated fatty acids in regulating FGF21 expression.	Fatty Acids, Unsaturated	74-97	fibroblast growth factor 21	Mus musculus	112-117
22866055-5	2012	The down-regulation of the AtFAD-2 gene substantially increased oleic acid from the normal levels of ~15% to as high as 63.3 and reduced total PUFA content (18:2(Delta9,12) + 18:3(Delta9,12,15) + 20:2(Delta11,14) + 20:3(Delta11,14,17)) from 46.8 to 4.8%.	Fatty Acids, Unsaturated	143-147	fatty acid desaturase 2	Arabidopsis thaliana	27-34
22466357-10	2012	Interestingly, unsaturated fatty acids were common activators or inhibitors of HR96 activity, indicating a link between diet and toxicant response.	Fatty Acids, Unsaturated	15-38	Hormone receptor-like in 96	Drosophila melanogaster	79-83
22720915-5	2012	The milk fatty acid composition showed higher concentrations of saturated fatty acids and lower concentrations of unsaturated fatty acids in milk fat from Danish Jerseys compared with Danish Holsteins.	Fatty Acids, Unsaturated	114-137	Weaning weight-maternal milk	Bos taurus	4-8
22720915-5	2012	The milk fatty acid composition showed higher concentrations of saturated fatty acids and lower concentrations of unsaturated fatty acids in milk fat from Danish Jerseys compared with Danish Holsteins.	Fatty Acids, Unsaturated	114-137	Weaning weight-maternal milk	Bos taurus	141-145
22647268-3	2012	It has been suggested that PC synthesis by PEMT plays an important role in the transport of polyunsaturated fatty acids (PUFAs) like docosahexaenoic acid (DHA) from the liver to plasma and possibly other tissues.	Fatty Acids, Unsaturated	92-119	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	43-47
22390974-4	2012	Diverse PUFA including docosahexaenoic acid (DHA) are in vitro ligands for GPR40, but nobody knows its downstream pathway.	Fatty Acids, Unsaturated	8-12	free fatty acid receptor 1	Homo sapiens	75-80
22124782-1	2012	Linoleic acid (LA), a dietary unsaturated fatty acid, has been known to increase the expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) through the activation of nuclear factor-kappa B. Rho/Rho-kinase (ROCK) pathway mediates various cellular functions related to cardiovascular disease and affects the expression of ICAM-1.	Fatty Acids, Unsaturated	30-52	intercellular adhesion molecule 1	Homo sapiens	126-159
22124782-1	2012	Linoleic acid (LA), a dietary unsaturated fatty acid, has been known to increase the expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) through the activation of nuclear factor-kappa B. Rho/Rho-kinase (ROCK) pathway mediates various cellular functions related to cardiovascular disease and affects the expression of ICAM-1.	Fatty Acids, Unsaturated	30-52	intercellular adhesion molecule 1	Homo sapiens	161-167
22415588-5	2012	The unsaturated fatty acid eicosapentaenoic acid and the dominant negative sterol regulatory element binding protein 1c (SREBP1c) were used to inhibit endogenous SREBP1c and evaluate the involvement of SREBP1c in beta cell dysfunction induced by LXR activation.	Fatty Acids, Unsaturated	4-26	sterol regulatory element binding transcription factor 1	Mus musculus	162-169
22415588-5	2012	The unsaturated fatty acid eicosapentaenoic acid and the dominant negative sterol regulatory element binding protein 1c (SREBP1c) were used to inhibit endogenous SREBP1c and evaluate the involvement of SREBP1c in beta cell dysfunction induced by LXR activation.	Fatty Acids, Unsaturated	4-26	sterol regulatory element binding transcription factor 1	Mus musculus	162-169
22647268-3	2012	It has been suggested that PC synthesis by PEMT plays an important role in the transport of polyunsaturated fatty acids (PUFAs) like docosahexaenoic acid (DHA) from the liver to plasma and possibly other tissues.	Fatty Acids, Unsaturated	121-126	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	43-47
22499883-8	2012	Mos breed showed a higher percentage of polyunsaturated fatty acids (25.90 vs. 22.74; P &lt; 0.001) and a lower percentage of monounsaturated fatty acids (35.14 vs. 38.95; P &lt; 0.001) than Sasso T-44 chicken muscles.	Fatty Acids, Unsaturated	40-67	v-mos Moloney murine sarcoma viral oncogene homolog	Gallus gallus	0-3
25049605-1	2012	The FAT-1 protein is an n-3 fatty acid desaturase, which can recognize a range of 18- and 20-carbon n-6 substrates and transform n-6 polyunsaturated fatty acids (PUFAs) into n-3 PUFAs while n-3 PUFAs have beneficial effect on human health.	Fatty Acids, Unsaturated	162-167	FAT atypical cadherin 1	Homo sapiens	4-9
21929559-2	2012	Attempting to identify cellular factors that affect alpha-Syn neuropathology, we previously reported that polyunsaturated fatty acids (PUFAs) promote alpha-Syn oligomerization and aggregation in cultured cells.	Fatty Acids, Unsaturated	106-133	synuclein, alpha	Mus musculus	52-61
21929559-2	2012	Attempting to identify cellular factors that affect alpha-Syn neuropathology, we previously reported that polyunsaturated fatty acids (PUFAs) promote alpha-Syn oligomerization and aggregation in cultured cells.	Fatty Acids, Unsaturated	106-133	joined toes	Mus musculus	58-61
21929559-2	2012	Attempting to identify cellular factors that affect alpha-Syn neuropathology, we previously reported that polyunsaturated fatty acids (PUFAs) promote alpha-Syn oligomerization and aggregation in cultured cells.	Fatty Acids, Unsaturated	135-140	synuclein, alpha	Mus musculus	52-61
21929559-2	2012	Attempting to identify cellular factors that affect alpha-Syn neuropathology, we previously reported that polyunsaturated fatty acids (PUFAs) promote alpha-Syn oligomerization and aggregation in cultured cells.	Fatty Acids, Unsaturated	135-140	joined toes	Mus musculus	58-61
22338035-0	2012	PUFAs acutely affect triacylglycerol-derived skeletal muscle fatty acid uptake and increase postprandial insulin sensitivity.	Fatty Acids, Unsaturated	0-5	insulin	Homo sapiens	105-112
22338035-11	2012	CONCLUSION: PUFAs reduced triacylglycerol-derived skeletal muscle FA uptake, which was accompanied by higher postprandial insulin sensitivity, a more transcriptional oxidative phenotype, and altered intramyocellular lipid partitioning and may therefore be protective against the development of insulin resistance.	Fatty Acids, Unsaturated	12-17	insulin	Homo sapiens	122-129
22338035-11	2012	CONCLUSION: PUFAs reduced triacylglycerol-derived skeletal muscle FA uptake, which was accompanied by higher postprandial insulin sensitivity, a more transcriptional oxidative phenotype, and altered intramyocellular lipid partitioning and may therefore be protective against the development of insulin resistance.	Fatty Acids, Unsaturated	12-17	insulin	Homo sapiens	294-301
22342273-8	2012	Also in biological membranes from the hem1  mutant strain the effect of squalene per se is difficult to pinpoint because multiple effects such as levels of sterols and unsaturated fatty acids contribute to physical membrane properties.	Fatty Acids, Unsaturated	168-191	5-aminolevulinate synthase	Saccharomyces cerevisiae S288C	38-42
22378731-2	2012	We previously reported that an A G variant (rs12746200) of the cytosolic phospholipase A2 group IVA gene (PLA2G4A), which encodes the enzyme that liberates PUFAs from cellular membranes for leukotriene synthesis, decreases the risk of CVD.	Fatty Acids, Unsaturated	156-161	phospholipase A2 group IVA	Homo sapiens	106-113
22575042-0	2012	A lower proportion of dietary saturated/monounsaturated/polyunsaturated fatty acids reduces the expression of adiponectin in rats fed a high-fat diet.	Fatty Acids, Unsaturated	56-83	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	110-121
22211244-3	2012	Gene expression correlation analysis showed that genes involved in the mevalonate pathway and unsaturated fatty acid synthesis were negatively correlated with the expression of EGFR, MET and other growth factor receptor genes, as well as with the expression of genes involved in cell migration and adhesion.	Fatty Acids, Unsaturated	94-116	epidermal growth factor receptor	Homo sapiens	177-181
22279185-1	2012	12/15 lipoxygenase (12/15LO) oxidizes polyunsaturated fatty acids (PUFAs) to form bioactive lipid mediators.	Fatty Acids, Unsaturated	38-65	arachidonate 15-lipoxygenase	Mus musculus	0-18
22279185-1	2012	12/15 lipoxygenase (12/15LO) oxidizes polyunsaturated fatty acids (PUFAs) to form bioactive lipid mediators.	Fatty Acids, Unsaturated	67-72	arachidonate 15-lipoxygenase	Mus musculus	0-18
22279185-4	2012	Compared with SK controls, DK mice fed a PUFA-enriched diet had decreased plasma and liver lipid levels, hepatic lipogenic gene expression, VLDL secretion, and aortic atherosclerosis and increased VLDL turnover.	Fatty Acids, Unsaturated	41-45	CD320 antigen	Mus musculus	140-144
22279185-4	2012	Compared with SK controls, DK mice fed a PUFA-enriched diet had decreased plasma and liver lipid levels, hepatic lipogenic gene expression, VLDL secretion, and aortic atherosclerosis and increased VLDL turnover.	Fatty Acids, Unsaturated	41-45	CD320 antigen	Mus musculus	197-201
22194195-0	2012	Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms.	Fatty Acids, Unsaturated	0-26	fatty acid desaturase 2	Homo sapiens	121-126
22194195-1	2012	Minor alleles of polymorphisms in the fatty acid desaturase (FADS) gene cluster have been associated with reduced desaturation of the precursor polyunsaturated fatty acids (FAs) in small studies.	Fatty Acids, Unsaturated	144-171	stearoyl-CoA desaturase	Homo sapiens	38-59
22194195-1	2012	Minor alleles of polymorphisms in the fatty acid desaturase (FADS) gene cluster have been associated with reduced desaturation of the precursor polyunsaturated fatty acids (FAs) in small studies.	Fatty Acids, Unsaturated	144-171	stearoyl-CoA desaturase	Homo sapiens	61-65
22198184-4	2012	Herein, we review the stress signaling pathways elicited by electrophiles derived from unsaturated fatty acids, focusing on the Keap1-Nrf2 pathway, the heat shock response pathway (HSR), and the unfolded protein response pathway (UPR).	Fatty Acids, Unsaturated	87-110	kelch like ECH associated protein 1	Homo sapiens	128-133
22267742-8	2012	Yeast lacking Gat1p (but not Gat2p) were sensitive to oleate and failed to accumulate LPs induced by this unsaturated fatty acid.	Fatty Acids, Unsaturated	106-128	Gat1p	Saccharomyces cerevisiae S288C	14-19
22198184-4	2012	Herein, we review the stress signaling pathways elicited by electrophiles derived from unsaturated fatty acids, focusing on the Keap1-Nrf2 pathway, the heat shock response pathway (HSR), and the unfolded protein response pathway (UPR).	Fatty Acids, Unsaturated	87-110	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
22020260-4	2012	Furthermore, we and others have shown that unsaturated fatty acids reduce ABCA1-mediated cholesterol efflux, and that this effect is mediated by the acyl-CoA derivatives of the fatty acids.	Fatty Acids, Unsaturated	43-66	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	74-79
22020260-7	2012	Conversely, overexpression of ACSL1 resulted in reduced ABCA1 levels and reduced cholesterol efflux in the presence of unsaturated fatty acids.	Fatty Acids, Unsaturated	119-142	acyl-CoA synthetase long-chain family member 1	Mus musculus	30-35
22106967-0	2012	Proteomic analysis of colon tissue from interleukin-10 gene-deficient mice fed polyunsaturated Fatty acids with comparison to transcriptomic analysis.	Fatty Acids, Unsaturated	79-106	interleukin 10	Mus musculus	40-54
22293571-1	2012	BACKGROUND/OBJECTIVES: Elongases 2, 4 and 5, encoded by genes ELOVL2, ELOVL4 and ELOVL5, have a key role in the biosynthesis of very long chain polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	144-171	ELOVL fatty acid elongase 2	Homo sapiens	62-68
22293571-1	2012	BACKGROUND/OBJECTIVES: Elongases 2, 4 and 5, encoded by genes ELOVL2, ELOVL4 and ELOVL5, have a key role in the biosynthesis of very long chain polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	144-171	ELOVL fatty acid elongase 4	Homo sapiens	70-76
22293571-1	2012	BACKGROUND/OBJECTIVES: Elongases 2, 4 and 5, encoded by genes ELOVL2, ELOVL4 and ELOVL5, have a key role in the biosynthesis of very long chain polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	144-171	ELOVL fatty acid elongase 5	Homo sapiens	81-87
22178644-1	2012	The polyunsaturated fatty acids (PUFAs), arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), important second messengers in brain, are released from membrane phospholipid following receptor-mediated activation of specific phospholipase A(2) (PLA(2)) enzymes.	Fatty Acids, Unsaturated	4-31	phospholipase A2 group IB	Homo sapiens	242-260
22178644-1	2012	The polyunsaturated fatty acids (PUFAs), arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), important second messengers in brain, are released from membrane phospholipid following receptor-mediated activation of specific phospholipase A(2) (PLA(2)) enzymes.	Fatty Acids, Unsaturated	4-31	phospholipase A2 group IB	Homo sapiens	262-268
22178644-1	2012	The polyunsaturated fatty acids (PUFAs), arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), important second messengers in brain, are released from membrane phospholipid following receptor-mediated activation of specific phospholipase A(2) (PLA(2)) enzymes.	Fatty Acids, Unsaturated	33-38	phospholipase A2 group IB	Homo sapiens	242-260
22178644-1	2012	The polyunsaturated fatty acids (PUFAs), arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), important second messengers in brain, are released from membrane phospholipid following receptor-mediated activation of specific phospholipase A(2) (PLA(2)) enzymes.	Fatty Acids, Unsaturated	33-38	phospholipase A2 group IB	Homo sapiens	262-268
22206977-16	2012	A reduction in cell proliferation can be observed when the enzyme is directly inhibited by the administration of synthetic specific inhibitors, antisense oligonucleotides, or siRNA or indirectly inhibited by the induction of peroxisome proliferator-activated receptor gamma (PPARgamma) with polyunsaturated fatty acids or PPARgamma transfection.	Fatty Acids, Unsaturated	291-318	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	225-273
22206977-16	2012	A reduction in cell proliferation can be observed when the enzyme is directly inhibited by the administration of synthetic specific inhibitors, antisense oligonucleotides, or siRNA or indirectly inhibited by the induction of peroxisome proliferator-activated receptor gamma (PPARgamma) with polyunsaturated fatty acids or PPARgamma transfection.	Fatty Acids, Unsaturated	291-318	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	275-284
22106967-4	2012	Both PUFA treatments showed anti-inflammatory activity; EPA appeared to act via the PPARalpha pathway, whereas AA appeared to increase energy metabolism and cytoskeletal organization and reduce cellular stress responses, possibly enabling a more robust response to inflammation.	Fatty Acids, Unsaturated	5-9	peroxisome proliferator activated receptor alpha	Mus musculus	84-93
22221030-3	2012	The "AA" genotype of the FASN SNP was significantly associated with higher concentrations of SFAs of 10:0, 12:0, 13:0, 14:0 and 15:0, lower concentrations of unsaturated fatty acids of 9c-18:1 and 20:3n-6, and higher concentrations of unsaturated fatty acids of 9c-14:1 and 12c-16:1 (P &lt; 0.05).	Fatty Acids, Unsaturated	158-181	fatty acid synthase	Bos taurus	25-29
22221030-3	2012	The "AA" genotype of the FASN SNP was significantly associated with higher concentrations of SFAs of 10:0, 12:0, 13:0, 14:0 and 15:0, lower concentrations of unsaturated fatty acids of 9c-18:1 and 20:3n-6, and higher concentrations of unsaturated fatty acids of 9c-14:1 and 12c-16:1 (P &lt; 0.05).	Fatty Acids, Unsaturated	235-258	fatty acid synthase	Bos taurus	25-29
22040870-1	2012	Unsaturated fatty acids are ligands of PPAR-gamma, which up-regulates genes involved in fatty acid transport and TAG synthesis and the insulin-sensitising adipokine adiponectin, which activates fatty acid beta-oxidation via PPAR-alpha action in liver.	Fatty Acids, Unsaturated	0-23	peroxisome proliferator activated receptor gamma	Homo sapiens	39-49
20946320-6	2012	TREK-1 channel activity is tightly regulated by intracellular and extracellular pH, membrane stretch, polyunsaturated fatty acids (PUFAs), temperature, and receptor-coupled second messenger systems.	Fatty Acids, Unsaturated	102-129	potassium two pore domain channel subfamily K member 2	Homo sapiens	0-6
22114848-7	2012	Polymorphisms in the SCD5 and INSIG2 genes were the most representative markers associated with SFA/unsaturated fatty acid (UFA) ratio in milk.	Fatty Acids, Unsaturated	100-122	stearoyl-CoA desaturase 5	Bos taurus	21-25
22114848-7	2012	Polymorphisms in the SCD5 and INSIG2 genes were the most representative markers associated with SFA/unsaturated fatty acid (UFA) ratio in milk.	Fatty Acids, Unsaturated	100-122	insulin induced gene 2	Bos taurus	30-36
22159221-0	2012	Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer.	Fatty Acids, Unsaturated	18-45	phosphatase and tensin homolog	Homo sapiens	70-74
22123669-1	2012	PURPOSE OF REVIEW: The Delta5 desaturase (D5D) and Delta6 desaturase (D6D) are key enzymes in the metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	112-139	fatty acid desaturase 1	Homo sapiens	29-40
22123669-1	2012	PURPOSE OF REVIEW: The Delta5 desaturase (D5D) and Delta6 desaturase (D6D) are key enzymes in the metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	112-139	fatty acid desaturase 1	Homo sapiens	42-45
22123669-1	2012	PURPOSE OF REVIEW: The Delta5 desaturase (D5D) and Delta6 desaturase (D6D) are key enzymes in the metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	112-139	fatty acid desaturase 2	Homo sapiens	57-68
22123669-1	2012	PURPOSE OF REVIEW: The Delta5 desaturase (D5D) and Delta6 desaturase (D6D) are key enzymes in the metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	112-139	fatty acid desaturase 2	Homo sapiens	70-73
22040870-1	2012	Unsaturated fatty acids are ligands of PPAR-gamma, which up-regulates genes involved in fatty acid transport and TAG synthesis and the insulin-sensitising adipokine adiponectin, which activates fatty acid beta-oxidation via PPAR-alpha action in liver.	Fatty Acids, Unsaturated	0-23	adiponectin, C1Q and collagen domain containing	Homo sapiens	165-176
22040870-1	2012	Unsaturated fatty acids are ligands of PPAR-gamma, which up-regulates genes involved in fatty acid transport and TAG synthesis and the insulin-sensitising adipokine adiponectin, which activates fatty acid beta-oxidation via PPAR-alpha action in liver.	Fatty Acids, Unsaturated	0-23	peroxisome proliferator activated receptor alpha	Homo sapiens	224-234
22257447-9	2012	CONCLUSIONS: Our findings may be of pathophysiological relevance since lysophosphatidylcholines, byproducts of phospholipase A2-catalyzed phospholipid hydrolysis, are preferred carriers of polyunsaturated fatty acids across the blood-brain barrier.	Fatty Acids, Unsaturated	189-216	phospholipase A2 group IB	Homo sapiens	111-127
22227195-3	2012	Fatty acid remodeling of GPI-APs in the Golgi apparatus is required for their efficient association with lipid rafts, i.e., the unsaturated fatty acid at the sn-2 position of the PI moiety is exchanged for the saturated fatty acid by PGAP2 and PGAP3.	Fatty Acids, Unsaturated	128-150	post-GPI attachment to proteins 2	Mus musculus	234-239
22227195-3	2012	Fatty acid remodeling of GPI-APs in the Golgi apparatus is required for their efficient association with lipid rafts, i.e., the unsaturated fatty acid at the sn-2 position of the PI moiety is exchanged for the saturated fatty acid by PGAP2 and PGAP3.	Fatty Acids, Unsaturated	128-150	post-GPI attachment to proteins 3	Mus musculus	244-249
22371399-6	2012	Polyunsaturated fatty acids supplied in the diet did affect the development of insulin-sensitive tissues during both the fetal and postnatal period.	Fatty Acids, Unsaturated	0-27	insulin	Homo sapiens	79-86
21903140-7	2012	These findings substantiate the importance of the fat composition in a diet, indicating that those rich in saturated compared to unsaturated fatty acids may promote overeating by increasing circulating lipids and specific hypothalamic peptides, GAL and OX, known to preferentially stimulate the consumption of a fat-rich diet.	Fatty Acids, Unsaturated	129-152	galanin and GMAP prepropeptide	Rattus norvegicus	245-248
21903140-7	2012	These findings substantiate the importance of the fat composition in a diet, indicating that those rich in saturated compared to unsaturated fatty acids may promote overeating by increasing circulating lipids and specific hypothalamic peptides, GAL and OX, known to preferentially stimulate the consumption of a fat-rich diet.	Fatty Acids, Unsaturated	129-152	hypocretin neuropeptide precursor	Rattus norvegicus	253-255
22065576-2	2012	A lipid product of PLC, diacylglycerol (DAG), and its metabolites, polyunsaturated fatty acids (PUFAs) may function as second messengers of channel activation.	Fatty Acids, Unsaturated	67-94	Phospholipase C at 21C	Drosophila melanogaster	19-22
22065576-2	2012	A lipid product of PLC, diacylglycerol (DAG), and its metabolites, polyunsaturated fatty acids (PUFAs) may function as second messengers of channel activation.	Fatty Acids, Unsaturated	96-101	Phospholipase C at 21C	Drosophila melanogaster	19-22
22110477-6	2012	In addition, ROS oxidize polyunsaturated fatty acids in mitochondrial cardiolipin and other phospholipids, and this impairs membrane integrity and leads to cytochrome c release into cytosol and apoptosis.	Fatty Acids, Unsaturated	25-52	cytochrome c, somatic	Homo sapiens	156-168
23678452-5	2012	RESULTS: Exposure of cells to the ERK1/2 pathway inhibitor induced an increase in monounsaturated fatty acids and the fatty acid desaturation index and a decrease in polyunsaturated fatty acid content.	Fatty Acids, Unsaturated	166-192	mitogen-activated protein kinase 3	Homo sapiens	34-40
21940900-2	2012	Recent evidence suggests that the anti-inflammatory/chemoprotective properties of fish oil (FO)-derived n-3 polyunsaturated fatty acids (PUFAs) may be partly mediated by PPARdelta.	Fatty Acids, Unsaturated	137-142	peroxisome proliferator activator receptor delta	Mus musculus	170-179
21968070-0	2012	Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3.	Fatty Acids, Unsaturated	0-27	1-acylglycerol-3-phosphate O-acyltransferase 3	Mus musculus	86-125
22487606-1	2012	BACKGROUND: Despite the fact that previous studies have indicated the significant roles of polyunsaturated fatty acids (PUFAs) in the immune system through peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma, the biological functions and the mechanisms of action in eosinophils are poorly understood.	Fatty Acids, Unsaturated	120-125	peroxisome proliferator activated receptor alpha	Homo sapiens	206-215
22487606-1	2012	BACKGROUND: Despite the fact that previous studies have indicated the significant roles of polyunsaturated fatty acids (PUFAs) in the immune system through peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma, the biological functions and the mechanisms of action in eosinophils are poorly understood.	Fatty Acids, Unsaturated	120-125	peroxisome proliferator activated receptor gamma	Homo sapiens	221-230
22487606-1	2012	BACKGROUND: Despite the fact that previous studies have indicated the significant roles of polyunsaturated fatty acids (PUFAs) in the immune system through peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma, the biological functions and the mechanisms of action in eosinophils are poorly understood.	Fatty Acids, Unsaturated	91-118	peroxisome proliferator activated receptor alpha	Homo sapiens	156-204
22442634-11	2012	Niacin and/or omega-3 PUFAs minimally affected cyclooxygenase-1 activity and had no effect on cyclooxygenase -2 activity.	Fatty Acids, Unsaturated	22-27	prostaglandin-endoperoxide synthase 1	Homo sapiens	47-63
22487606-1	2012	BACKGROUND: Despite the fact that previous studies have indicated the significant roles of polyunsaturated fatty acids (PUFAs) in the immune system through peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma, the biological functions and the mechanisms of action in eosinophils are poorly understood.	Fatty Acids, Unsaturated	91-118	peroxisome proliferator activated receptor alpha	Homo sapiens	206-215
22487606-1	2012	BACKGROUND: Despite the fact that previous studies have indicated the significant roles of polyunsaturated fatty acids (PUFAs) in the immune system through peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma, the biological functions and the mechanisms of action in eosinophils are poorly understood.	Fatty Acids, Unsaturated	91-118	peroxisome proliferator activated receptor gamma	Homo sapiens	221-230
22487606-1	2012	BACKGROUND: Despite the fact that previous studies have indicated the significant roles of polyunsaturated fatty acids (PUFAs) in the immune system through peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma, the biological functions and the mechanisms of action in eosinophils are poorly understood.	Fatty Acids, Unsaturated	120-125	peroxisome proliferator activated receptor alpha	Homo sapiens	156-204
22121489-4	2012	This study investigated in wild-type mice if a PUFA diet enriched in docosahexanoic acid (DHA) restored blood-brain barrier integrity and attenuated parenchymal apo B abundance induced by chronic ingestion of SFA.	Fatty Acids, Unsaturated	47-51	apolipoprotein B	Mus musculus	161-166
21684139-5	2012	Studies have shown that unsaturated fatty acids, but not saturated fatty acids, repress the expression of ABCA1 in vitro.	Fatty Acids, Unsaturated	24-47	ATP binding cassette subfamily A member 1	Homo sapiens	106-111
22045927-3	2012	The objective of this study was to test the association of CPT1A variants with body composition and lipids, mediated by consumption of polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	135-162	carnitine palmitoyltransferase 1A	Homo sapiens	59-64
22045927-3	2012	The objective of this study was to test the association of CPT1A variants with body composition and lipids, mediated by consumption of polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	164-168	carnitine palmitoyltransferase 1A	Homo sapiens	59-64
21684139-6	2012	Although information on mechanisms for the fatty-acid-mediated regulation of ABCA1 expression is still limited and controversial, recent evidence suggests that unsaturated fatty acids inhibit the expression of ABCA1 at the transcriptional and posttranscriptional levels.	Fatty Acids, Unsaturated	160-183	ATP binding cassette subfamily A member 1	Homo sapiens	210-215
21684139-7	2012	The transcriptional repression of ABCA1 expression by unsaturated fatty acids is likely liver X receptor dependent.	Fatty Acids, Unsaturated	54-77	ATP binding cassette subfamily A member 1	Homo sapiens	34-39
21684139-9	2012	Posttranscriptionally, unsaturated fatty acids may facilitate ABCA1 protein degradation, which may involve phosphorylation of ABCA1 by protein kinases.	Fatty Acids, Unsaturated	23-46	ATP binding cassette subfamily A member 1	Homo sapiens	62-67
21684139-9	2012	Posttranscriptionally, unsaturated fatty acids may facilitate ABCA1 protein degradation, which may involve phosphorylation of ABCA1 by protein kinases.	Fatty Acids, Unsaturated	23-46	ATP binding cassette subfamily A member 1	Homo sapiens	126-131
23049748-0	2012	Dampening of hyperexcitability in CA1 pyramidal neurons by polyunsaturated fatty acids acting on voltage-gated ion channels.	Fatty Acids, Unsaturated	59-86	carbonic anhydrase 1	Homo sapiens	34-37
22584290-7	2012	Comparison of the effects of Fabp2 loss in individual sexes revealed a male-specific upregulation of 5 pathways involved in the production of unsaturated fatty acids, and a female-specific downregulation of pathways involved in xenobiotic metabolism.	Fatty Acids, Unsaturated	142-165	fatty acid binding protein 2, intestinal	Mus musculus	29-34
23077527-9	2012	Utilizing the demonstrated effect of polyunsaturated fatty acids (PUFA) to enhance alpha-Syn neuropathology, we show an in vivo effect for brain docosahexaenoic acid (DHA) levels on alpha-Syn localization to oligodendrocytes in brains of a mouse model for synucleinopathies, expressing human A53T alpha-Syn cDNA under the PrP promoter.	Fatty Acids, Unsaturated	37-64	synuclein, alpha	Mus musculus	83-92
23077527-9	2012	Utilizing the demonstrated effect of polyunsaturated fatty acids (PUFA) to enhance alpha-Syn neuropathology, we show an in vivo effect for brain docosahexaenoic acid (DHA) levels on alpha-Syn localization to oligodendrocytes in brains of a mouse model for synucleinopathies, expressing human A53T alpha-Syn cDNA under the PrP promoter.	Fatty Acids, Unsaturated	37-64	synuclein, alpha	Mus musculus	182-191
23077527-9	2012	Utilizing the demonstrated effect of polyunsaturated fatty acids (PUFA) to enhance alpha-Syn neuropathology, we show an in vivo effect for brain docosahexaenoic acid (DHA) levels on alpha-Syn localization to oligodendrocytes in brains of a mouse model for synucleinopathies, expressing human A53T alpha-Syn cDNA under the PrP promoter.	Fatty Acids, Unsaturated	37-64	synemin	Homo sapiens	89-92
23077527-9	2012	Utilizing the demonstrated effect of polyunsaturated fatty acids (PUFA) to enhance alpha-Syn neuropathology, we show an in vivo effect for brain docosahexaenoic acid (DHA) levels on alpha-Syn localization to oligodendrocytes in brains of a mouse model for synucleinopathies, expressing human A53T alpha-Syn cDNA under the PrP promoter.	Fatty Acids, Unsaturated	66-70	synuclein, alpha	Mus musculus	83-92
23077527-9	2012	Utilizing the demonstrated effect of polyunsaturated fatty acids (PUFA) to enhance alpha-Syn neuropathology, we show an in vivo effect for brain docosahexaenoic acid (DHA) levels on alpha-Syn localization to oligodendrocytes in brains of a mouse model for synucleinopathies, expressing human A53T alpha-Syn cDNA under the PrP promoter.	Fatty Acids, Unsaturated	66-70	synuclein, alpha	Mus musculus	182-191
23077527-9	2012	Utilizing the demonstrated effect of polyunsaturated fatty acids (PUFA) to enhance alpha-Syn neuropathology, we show an in vivo effect for brain docosahexaenoic acid (DHA) levels on alpha-Syn localization to oligodendrocytes in brains of a mouse model for synucleinopathies, expressing human A53T alpha-Syn cDNA under the PrP promoter.	Fatty Acids, Unsaturated	66-70	synemin	Homo sapiens	89-92
21927955-3	2012	Based on our experimental results as well as increased knowledge about the pro-neuroinflammatory potential of glial water channels, we propose that induction of aquaporin-4 can be a critical initiating factor in alcohol"s neurotoxic effects, through the instigation of cellular edema-based neuroinflammatory cascades involving increased phospholipase A2 activities, polyunsaturated fatty acid release/membrane depletion, decreased prosurvival signaling, and oxidative stress.	Fatty Acids, Unsaturated	366-392	aquaporin 4	Rattus norvegicus	161-172
23285160-1	2012	15-Lipoxygenase-1 (15-LOX-1) oxidizes polyunsaturated fatty acids to a rich spectrum of biologically active metabolites and is implicated in physiological membrane remodelling, inflammation and apoptosis.	Fatty Acids, Unsaturated	38-65	arachidonate 15-lipoxygenase	Homo sapiens	0-17
23285160-1	2012	15-Lipoxygenase-1 (15-LOX-1) oxidizes polyunsaturated fatty acids to a rich spectrum of biologically active metabolites and is implicated in physiological membrane remodelling, inflammation and apoptosis.	Fatty Acids, Unsaturated	38-65	arachidonate 15-lipoxygenase	Homo sapiens	19-27
22048864-2	2011	Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the omega-3 and omega-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death.	Fatty Acids, Unsaturated	49-76	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	183-199
22723860-0	2012	TRPA1 is a polyunsaturated fatty acid sensor in mammals.	Fatty Acids, Unsaturated	11-37	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
22723860-3	2012	Here we show that Transient Receptor Potential Ankyrin 1 (TRPA1), a cation channel expressed in sensory neurons and gut tissues, functions as a sensor of polyunsaturated fatty acids (PUFAs) in vitro and in vivo.	Fatty Acids, Unsaturated	154-181	transient receptor potential cation channel subfamily A member 1	Homo sapiens	18-56
22723860-3	2012	Here we show that Transient Receptor Potential Ankyrin 1 (TRPA1), a cation channel expressed in sensory neurons and gut tissues, functions as a sensor of polyunsaturated fatty acids (PUFAs) in vitro and in vivo.	Fatty Acids, Unsaturated	154-181	transient receptor potential cation channel subfamily A member 1	Homo sapiens	58-63
22723860-3	2012	Here we show that Transient Receptor Potential Ankyrin 1 (TRPA1), a cation channel expressed in sensory neurons and gut tissues, functions as a sensor of polyunsaturated fatty acids (PUFAs) in vitro and in vivo.	Fatty Acids, Unsaturated	183-188	transient receptor potential cation channel subfamily A member 1	Homo sapiens	18-56
22723860-3	2012	Here we show that Transient Receptor Potential Ankyrin 1 (TRPA1), a cation channel expressed in sensory neurons and gut tissues, functions as a sensor of polyunsaturated fatty acids (PUFAs) in vitro and in vivo.	Fatty Acids, Unsaturated	183-188	transient receptor potential cation channel subfamily A member 1	Homo sapiens	58-63
22723860-4	2012	PUFAs, containing at least 18 carbon atoms and three unsaturated bonds, activate TRPA1 to excite primary sensory neurons and enteroendocrine cells.	Fatty Acids, Unsaturated	0-5	transient receptor potential cation channel subfamily A member 1	Homo sapiens	81-86
22629460-0	2012	Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake.	Fatty Acids, Unsaturated	135-139	patatin like phospholipase domain containing 3	Homo sapiens	93-99
22384013-1	2012	BACKGROUND: Synthesis of polyunsaturated fatty acids (PUFAs) in the endoplasmic reticulum of plants typically involves the fatty acid desaturases FAD2 and FAD3, which use cytochrome b(5) (Cb5) as an electron donor.	Fatty Acids, Unsaturated	25-52	omega-6 fatty acid desaturase	Glycine max	146-150
22384013-1	2012	BACKGROUND: Synthesis of polyunsaturated fatty acids (PUFAs) in the endoplasmic reticulum of plants typically involves the fatty acid desaturases FAD2 and FAD3, which use cytochrome b(5) (Cb5) as an electron donor.	Fatty Acids, Unsaturated	25-52	fatty acid desaturase 3	Arabidopsis thaliana	155-159
22384013-1	2012	BACKGROUND: Synthesis of polyunsaturated fatty acids (PUFAs) in the endoplasmic reticulum of plants typically involves the fatty acid desaturases FAD2 and FAD3, which use cytochrome b(5) (Cb5) as an electron donor.	Fatty Acids, Unsaturated	25-52	cytochrome b5 type A	Homo sapiens	171-186
22093549-6	2012	RESULTS: From 25 to 40 weeks gestation, saturated-FA (SAFA) increased from 83 to 298 mg/g WAT and monounsaturated-FA (MUFA) from 83 to 226 mg/g WAT, while polyunsaturated-FA (PUFA) increased insignificantly from 18.0 to 23.2 mg/g WAT.	Fatty Acids, Unsaturated	155-173	heterogeneous nuclear ribonucleoprotein U	Homo sapiens	54-58
22093549-6	2012	RESULTS: From 25 to 40 weeks gestation, saturated-FA (SAFA) increased from 83 to 298 mg/g WAT and monounsaturated-FA (MUFA) from 83 to 226 mg/g WAT, while polyunsaturated-FA (PUFA) increased insignificantly from 18.0 to 23.2 mg/g WAT.	Fatty Acids, Unsaturated	175-179	heterogeneous nuclear ribonucleoprotein U	Homo sapiens	54-58
21978921-0	2011	Dietary polyunsaturated fatty acids may increase plasma LDL-cholesterol and plasma cholesterol concentrations in carriers of an ABCG1 gene single nucleotide polymorphism: study in two Spanish populations.	Fatty Acids, Unsaturated	8-35	ATP binding cassette subfamily G member 1	Homo sapiens	128-133
22005953-6	2011	Polyunsaturated fatty acids and their products seem to modulate the expression of ephrin Bs and reelin and several adhesion molecules and microRNAs suggesting that bioactive lipids participate in neuronal regeneration and stem cell proliferation, migration, and cancer cell metastasis.	Fatty Acids, Unsaturated	0-27	reelin	Homo sapiens	96-102
22384013-1	2012	BACKGROUND: Synthesis of polyunsaturated fatty acids (PUFAs) in the endoplasmic reticulum of plants typically involves the fatty acid desaturases FAD2 and FAD3, which use cytochrome b(5) (Cb5) as an electron donor.	Fatty Acids, Unsaturated	25-52	cytochrome b5 type A	Homo sapiens	188-191
22384013-1	2012	BACKGROUND: Synthesis of polyunsaturated fatty acids (PUFAs) in the endoplasmic reticulum of plants typically involves the fatty acid desaturases FAD2 and FAD3, which use cytochrome b(5) (Cb5) as an electron donor.	Fatty Acids, Unsaturated	54-59	omega-6 fatty acid desaturase	Glycine max	146-150
22384013-1	2012	BACKGROUND: Synthesis of polyunsaturated fatty acids (PUFAs) in the endoplasmic reticulum of plants typically involves the fatty acid desaturases FAD2 and FAD3, which use cytochrome b(5) (Cb5) as an electron donor.	Fatty Acids, Unsaturated	54-59	fatty acid desaturase 3	Arabidopsis thaliana	155-159
22384013-1	2012	BACKGROUND: Synthesis of polyunsaturated fatty acids (PUFAs) in the endoplasmic reticulum of plants typically involves the fatty acid desaturases FAD2 and FAD3, which use cytochrome b(5) (Cb5) as an electron donor.	Fatty Acids, Unsaturated	54-59	cytochrome b5 type A	Homo sapiens	171-186
22384013-1	2012	BACKGROUND: Synthesis of polyunsaturated fatty acids (PUFAs) in the endoplasmic reticulum of plants typically involves the fatty acid desaturases FAD2 and FAD3, which use cytochrome b(5) (Cb5) as an electron donor.	Fatty Acids, Unsaturated	54-59	cytochrome b5 type A	Homo sapiens	188-191
21301856-0	2011	Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men.	Fatty Acids, Unsaturated	34-61	C-reactive protein	Homo sapiens	84-102
21301856-0	2011	Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men.	Fatty Acids, Unsaturated	34-61	adiponectin, C1Q and collagen domain containing	Homo sapiens	107-118
22080018-19	2011	These results suggest that dietary and management strategies directed at modulating tissue polyunsaturated fatty acid status may offer the promise of modulating lipid metabolism and COX-2 expression in commercial poultry.	Fatty Acids, Unsaturated	91-117	prostaglandin-endoperoxide synthase 2	Homo sapiens	182-187
21688154-1	2011	Eicosadienoic acid (Delta11,14-20:2; EDA) is a rare, naturally occurring n-6 polyunsaturated fatty acid (PUFA) found mainly in animal tissues.	Fatty Acids, Unsaturated	105-109	ectodysplasin-A	Mus musculus	37-40
21897942-0	2011	Reactive uptake of NO3 radicals by unsaturated fatty acid particles.	Fatty Acids, Unsaturated	35-57	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
21962577-7	2011	After treatment of HepG2 cells with the compounds, only compound 5, a polyunsaturated fatty acid, strongly induced poly (ADP-ribose) polymerase (PARP) cleavage in a dose- and time-dependent manner and increased the activities of caspase-3, caspase-8, and caspase-9 at 100 muM.	Fatty Acids, Unsaturated	70-96	poly(ADP-ribose) polymerase 1	Homo sapiens	115-143
21962577-7	2011	After treatment of HepG2 cells with the compounds, only compound 5, a polyunsaturated fatty acid, strongly induced poly (ADP-ribose) polymerase (PARP) cleavage in a dose- and time-dependent manner and increased the activities of caspase-3, caspase-8, and caspase-9 at 100 muM.	Fatty Acids, Unsaturated	70-96	poly(ADP-ribose) polymerase 1	Homo sapiens	145-149
21962577-7	2011	After treatment of HepG2 cells with the compounds, only compound 5, a polyunsaturated fatty acid, strongly induced poly (ADP-ribose) polymerase (PARP) cleavage in a dose- and time-dependent manner and increased the activities of caspase-3, caspase-8, and caspase-9 at 100 muM.	Fatty Acids, Unsaturated	70-96	caspase 3	Homo sapiens	229-238
22031739-3	2011	We hypothesized that (1) GPx4 is enhanced in species that contain elevated levels of highly oxidizable polyunsaturated fatty acids (PUFA) and (2) activities of antioxidant enzymes are prioritized to meet species-specific oxidative stresses.	Fatty Acids, Unsaturated	103-130	glutathione peroxidase 4a	Fundulus heteroclitus	25-29
22031739-3	2011	We hypothesized that (1) GPx4 is enhanced in species that contain elevated levels of highly oxidizable polyunsaturated fatty acids (PUFA) and (2) activities of antioxidant enzymes are prioritized to meet species-specific oxidative stresses.	Fatty Acids, Unsaturated	132-136	glutathione peroxidase 4a	Fundulus heteroclitus	25-29
22468134-6	2011	As such, the relative effects of PUFAs and prostaglandins on PMPMEase could explain the association between cyclooxygenase-2 (COX-2) expression in tumors, the chemopreventive effects of the non-steroidal anti-inflammatory (NSAIDs) COX-2 inhibitors and PUFAs.	Fatty Acids, Unsaturated	33-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	108-124
22468134-6	2011	As such, the relative effects of PUFAs and prostaglandins on PMPMEase could explain the association between cyclooxygenase-2 (COX-2) expression in tumors, the chemopreventive effects of the non-steroidal anti-inflammatory (NSAIDs) COX-2 inhibitors and PUFAs.	Fatty Acids, Unsaturated	33-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	126-131
22468134-6	2011	As such, the relative effects of PUFAs and prostaglandins on PMPMEase could explain the association between cyclooxygenase-2 (COX-2) expression in tumors, the chemopreventive effects of the non-steroidal anti-inflammatory (NSAIDs) COX-2 inhibitors and PUFAs.	Fatty Acids, Unsaturated	33-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	231-236
22468134-6	2011	As such, the relative effects of PUFAs and prostaglandins on PMPMEase could explain the association between cyclooxygenase-2 (COX-2) expression in tumors, the chemopreventive effects of the non-steroidal anti-inflammatory (NSAIDs) COX-2 inhibitors and PUFAs.	Fatty Acids, Unsaturated	252-257	prostaglandin-endoperoxide synthase 2	Homo sapiens	126-131
22416705-0	2011	Two unsaturated fatty acids with potent alpha-glucosidase inhibitory activity purified from the body wall of sea cucumber (Stichopus japonicus).	Fatty Acids, Unsaturated	4-27	alpha-glucosidase	Cucumis sativus	40-57
22416705-2	2011	Two unsaturated fatty acids with strong alpha-glucosidase inhibitory activity, 7(Z)-octadecenoic acid (1) and 7(Z),10(Z)-octadecadienoic acid (2), were purified from the body wall of Stichopus japonicus.	Fatty Acids, Unsaturated	4-27	alpha-glucosidase	Cucumis sativus	40-57
21954435-7	2011	Both induction of SCD1 protein and sensitivity to growth inhibition by SCD1 inhibition could be reversed by supplementing growth media with unsaturated fatty acids, the product of the enzymatic reaction catalyzed by SCD1.	Fatty Acids, Unsaturated	140-163	stearoyl-CoA desaturase	Homo sapiens	18-22
21954435-7	2011	Both induction of SCD1 protein and sensitivity to growth inhibition by SCD1 inhibition could be reversed by supplementing growth media with unsaturated fatty acids, the product of the enzymatic reaction catalyzed by SCD1.	Fatty Acids, Unsaturated	140-163	stearoyl-CoA desaturase	Homo sapiens	71-75
21954435-7	2011	Both induction of SCD1 protein and sensitivity to growth inhibition by SCD1 inhibition could be reversed by supplementing growth media with unsaturated fatty acids, the product of the enzymatic reaction catalyzed by SCD1.	Fatty Acids, Unsaturated	140-163	stearoyl-CoA desaturase	Homo sapiens	71-75
22078495-0	2011	Association of an ACSL1 gene variant with polyunsaturated fatty acids in bovine skeletal muscle.	Fatty Acids, Unsaturated	42-69	fatty-acid-Coenzyme A ligase long chain 2	Bos taurus	18-23
21459495-0	2011	Brain histological changes in young mice submitted to diets with different ratios of n-6/n-3 polyunsaturated fatty acids during maternal pregnancy and lactation.	Fatty Acids, Unsaturated	93-120	notch 3	Mus musculus	89-92
21635958-5	2011	In addition, we studied the transcriptional regulation of LXR by hormones, a pro-inflammatory mediator and unsaturated fatty acids.	Fatty Acids, Unsaturated	107-130	oxysterols receptor LXR-alpha	Oncorhynchus mykiss	58-61
21459495-6	2011	As compared with the n-3 PUFA-deficient diet, both the flaxseed oil n-3 PUFA diets and the flaxseed/fish oil n-3 PUFA diets significantly increased the expression levels of brain neuron-specific enolase, glial fibrillary acidic protein and myelin basic protein, somewhat dose-dependently, in new pup mice at 21 d and 42 d of age.	Fatty Acids, Unsaturated	72-76	notch 3	Mus musculus	68-71
21459495-6	2011	As compared with the n-3 PUFA-deficient diet, both the flaxseed oil n-3 PUFA diets and the flaxseed/fish oil n-3 PUFA diets significantly increased the expression levels of brain neuron-specific enolase, glial fibrillary acidic protein and myelin basic protein, somewhat dose-dependently, in new pup mice at 21 d and 42 d of age.	Fatty Acids, Unsaturated	72-76	notch 3	Mus musculus	68-71
21459495-7	2011	The expression of PPAR-gamma in the brains of pup mice was increased only at 7 d of age with the n-3 PUFA diet, and no changes in the expression of PPAR-alpha and PPAR-beta were found among all the diet groups.	Fatty Acids, Unsaturated	101-105	peroxisome proliferator activated receptor gamma	Mus musculus	18-28
21635958-11	2011	Unsaturated fatty acids downregulated LXR gene expression.	Fatty Acids, Unsaturated	0-23	oxysterols receptor LXR-alpha	Oncorhynchus mykiss	38-41
21862612-0	2011	Unsaturated fatty acids stimulate LH secretion via novel PKCepsilon and -theta in gonadotrope cells and inhibit GnRH-induced LH release.	Fatty Acids, Unsaturated	0-23	protein kinase C, theta	Mus musculus	57-78
21778351-8	2011	A 24-h exposure of differentiated HepaRG cells to various polyunsaturated fatty acids and derivatives induced microvesicular steatosis; down-regulation of lipid metabolism gene regulators such as sterol regulatory element-binding protein-1c, fatty acid synthase, peroxisome proliferator-activated receptor gamma (PPARgamma), PPARalpha, and decreased expression of glucose-dependent metabolism genes, which could limit de novo lipogenesis.	Fatty Acids, Unsaturated	58-85	peroxisome proliferator activated receptor gamma	Homo sapiens	263-311
21778351-8	2011	A 24-h exposure of differentiated HepaRG cells to various polyunsaturated fatty acids and derivatives induced microvesicular steatosis; down-regulation of lipid metabolism gene regulators such as sterol regulatory element-binding protein-1c, fatty acid synthase, peroxisome proliferator-activated receptor gamma (PPARgamma), PPARalpha, and decreased expression of glucose-dependent metabolism genes, which could limit de novo lipogenesis.	Fatty Acids, Unsaturated	58-85	peroxisome proliferator activated receptor gamma	Homo sapiens	313-322
21778351-8	2011	A 24-h exposure of differentiated HepaRG cells to various polyunsaturated fatty acids and derivatives induced microvesicular steatosis; down-regulation of lipid metabolism gene regulators such as sterol regulatory element-binding protein-1c, fatty acid synthase, peroxisome proliferator-activated receptor gamma (PPARgamma), PPARalpha, and decreased expression of glucose-dependent metabolism genes, which could limit de novo lipogenesis.	Fatty Acids, Unsaturated	58-85	peroxisome proliferator activated receptor alpha	Homo sapiens	325-334
21862612-0	2011	Unsaturated fatty acids stimulate LH secretion via novel PKCepsilon and -theta in gonadotrope cells and inhibit GnRH-induced LH release.	Fatty Acids, Unsaturated	0-23	gonadotropin releasing hormone 1	Rattus norvegicus	112-116
21862612-11	2011	Altogether, these results suggest that the pituitary is a relevant site of FA action and that UFA may influence reproduction by directly interfering with basal and GnRH-dependent gonadotrope activity.	Fatty Acids, Unsaturated	94-97	gonadotropin releasing hormone 1	Rattus norvegicus	164-168
21703303-5	2011	Degradation of GPs by phospholipase A(2) can release two important brain polyunsaturated fatty acids (PUFAs), e.g., arachidonic acid and docosahexaenoic acid, linked together by a delicate equilibrium.	Fatty Acids, Unsaturated	73-100	phospholipase A2 group IB	Homo sapiens	22-39
21647637-1	2011	Microsomal delta-12 fatty acid desaturase (FAD2) functions in the first committed step of the biosynthesis of polyunsaturated fatty acids via the desaturation of oleic acid to linoleic acid.	Fatty Acids, Unsaturated	110-137	omega-6 fatty acid desaturase, endoplasmic reticulum	Brassica rapa	43-47
21703303-5	2011	Degradation of GPs by phospholipase A(2) can release two important brain polyunsaturated fatty acids (PUFAs), e.g., arachidonic acid and docosahexaenoic acid, linked together by a delicate equilibrium.	Fatty Acids, Unsaturated	102-107	phospholipase A2 group IB	Homo sapiens	22-39
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-246
22224257-11	2011	CONCLUSIONS: Omega-3 PUFA can effectively reduce serum level of TNF-alpha and levels of MIP-1alpha, NF-kappaBp65, and MIF in lung tissue of rats with severe scald, showing that it has a protective effect against injury of lung tissue.	Fatty Acids, Unsaturated	21-25	tumor necrosis factor	Rattus norvegicus	64-73
22224257-11	2011	CONCLUSIONS: Omega-3 PUFA can effectively reduce serum level of TNF-alpha and levels of MIP-1alpha, NF-kappaBp65, and MIF in lung tissue of rats with severe scald, showing that it has a protective effect against injury of lung tissue.	Fatty Acids, Unsaturated	21-25	C-C motif chemokine ligand 3	Rattus norvegicus	88-98
22224257-11	2011	CONCLUSIONS: Omega-3 PUFA can effectively reduce serum level of TNF-alpha and levels of MIP-1alpha, NF-kappaBp65, and MIF in lung tissue of rats with severe scald, showing that it has a protective effect against injury of lung tissue.	Fatty Acids, Unsaturated	21-25	macrophage migration inhibitory factor	Rattus norvegicus	118-121
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	insulin receptor substrate 1	Homo sapiens	248-252
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	insulin receptor substrate 2	Homo sapiens	254-258
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	cyclin D1	Homo sapiens	260-265
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	integrin subunit beta 3	Homo sapiens	267-272
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	BCL2 apoptosis regulator	Homo sapiens	274-278
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	sirtuin 1	Homo sapiens	280-285
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	tumor protein p53 inducible nuclear protein 1	Homo sapiens	287-295
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	KRAS proto-oncogene, GTPase	Homo sapiens	300-305
21562092-1	2011	BACKGROUND: Adiponectin gene expression is modulated by peroxisome proliferator-activated receptor gamma, which is a transcription factor activated by unsaturated fatty acids.	Fatty Acids, Unsaturated	151-174	adiponectin, C1Q and collagen domain containing	Homo sapiens	12-23
21308896-5	2011	Long-chain polyunsaturated fatty acids (PUFA) profiles were significantly altered in fat-3 mutants compared to wild type but were not altered after exposure to dietary cis- or trans-18:1n9.	Fatty Acids, Unsaturated	40-44	Delta(6)-fatty-acid desaturase fat-3;FA_desaturase domain-containing protein	Caenorhabditis elegans	85-90
21046125-0	2011	Unsaturated fatty acids repress the expression of adipocyte fatty acid binding protein via the modulation of histone deacetylation in RAW 264.7 macrophages.	Fatty Acids, Unsaturated	0-23	fatty acid binding protein 4, adipocyte	Mus musculus	50-86
21046125-7	2011	Unsaturated fatty acids (100 mumol/l in complexed with BSA) such as palmitoleic acid, oleic acid, linoleic acid, linolenic acid, and eicosapentaenoic acid, significantly repressed the basal as well as LPS-induced A-FABP expression, whereas palmitic acid did not elicit the same effect.	Fatty Acids, Unsaturated	0-23	fatty acid binding protein 4, adipocyte	Mus musculus	213-219
21046125-10	2011	CONCLUSION: Unsaturated fatty acids inhibited the basal as well as LPS-induced A-FABP expression.	Fatty Acids, Unsaturated	12-35	fatty acid binding protein 4, adipocyte	Mus musculus	79-85
21046125-11	2011	The mechanism may involve histone deacetylation and anti-inflammatory effect of unsaturated fatty acids may be at least in part attributed to their repression of A-FABP expression in RAW 264.7 macrophages.	Fatty Acids, Unsaturated	80-103	fatty acid binding protein 4, adipocyte	Mus musculus	162-168
21917707-9	2011	RESULTS: Both classes of PUFAs, omega-3 (omega-3) and omega-6 (omega-6), can cause a modest but very reproducible reduction of gene expression, protein production, and pump activity of MDR1.	Fatty Acids, Unsaturated	25-30	ATP binding cassette subfamily B member 1	Homo sapiens	185-189
21917707-12	2011	CONCLUSIONS: Our results suggest that inhibition of the multidrug resistance MDR1/P-gp is one mechanism through which dietary polyunsaturated fatty acids exert a synergetic effect on the response of tumor cells to anticancer drugs.	Fatty Acids, Unsaturated	126-153	ATP binding cassette subfamily B member 1	Homo sapiens	77-81
21917707-12	2011	CONCLUSIONS: Our results suggest that inhibition of the multidrug resistance MDR1/P-gp is one mechanism through which dietary polyunsaturated fatty acids exert a synergetic effect on the response of tumor cells to anticancer drugs.	Fatty Acids, Unsaturated	126-153	ATP binding cassette subfamily B member 1	Homo sapiens	82-86
21925348-4	2011	Our hypothesis was that THP-1 macrophages pretreated with omega-3 polyunsaturated fatty acids (PUFA) or fatty acid containing a cis double bond would accumulate less lipid, particularly cholesteryl ester, compared with omega-6 polyunsaturated fatty acids or a fatty acid containing a trans double bond, respectively.	Fatty Acids, Unsaturated	95-99	GLI family zinc finger 2	Homo sapiens	24-29
22440357-5	2011	Increasing the finishing time on concentrate significantly increased the saturated and monounsaturated fatty acids, whereas polyunsaturated fatty acids (PUFAs) tended to decrease and it was not possible to increase the long-chain PUFA content in muscle tissue of this breed.	Fatty Acids, Unsaturated	124-151	pumilio RNA binding family member 3	Homo sapiens	153-157
21544602-1	2011	Patients with cystic fibrosis, caused by mutations in CFTR, exhibit specific and consistent alterations in the levels of particular unsaturated fatty acids compared with healthy controls.	Fatty Acids, Unsaturated	132-155	CF transmembrane conductance regulator	Homo sapiens	54-58
21493730-2	2011	Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable channel that is activated by extracellular hypotonicity, polyunsaturated fatty acids, phorbol esters, and elevated temperature.	Fatty Acids, Unsaturated	128-155	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-40
21493730-2	2011	Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable channel that is activated by extracellular hypotonicity, polyunsaturated fatty acids, phorbol esters, and elevated temperature.	Fatty Acids, Unsaturated	128-155	transient receptor potential cation channel subfamily V member 4	Homo sapiens	42-47
21562092-1	2011	BACKGROUND: Adiponectin gene expression is modulated by peroxisome proliferator-activated receptor gamma, which is a transcription factor activated by unsaturated fatty acids.	Fatty Acids, Unsaturated	151-174	peroxisome proliferator activated receptor gamma	Homo sapiens	56-104
21570480-11	2011	PUFAs promote pathways, at a transcriptional level, that increase fat oxidation and synergize with factors from SC fat to abrogate PA-induced insulin resistance.	Fatty Acids, Unsaturated	0-5	insulin	Homo sapiens	142-149
21276281-10	2011	Rats fed the 5 % n-3 PUFA diet had lower (58 2 %; P &lt; 0 01) enterocytic phosphorylated JNK protein and secreted less cholesterol (30 %; P &lt; 0 05) into mesenteric lymph compared with the control.	Fatty Acids, Unsaturated	21-25	mitogen-activated protein kinase 8	Rattus norvegicus	90-93
21413848-1	2011	Increasing evidence suggests that fatty acid desaturases, rate-limiting enzymes in unsaturated fatty acid biosynthesis, are important factors in the pathogenesis of lipid-induced insulin resistance.	Fatty Acids, Unsaturated	83-105	insulin	Homo sapiens	179-186
21784308-0	2011	The relationships between erythrocyte membrane n-6 to n-3 polyunsaturated fatty acids ratio and blood lipids and C-reactive protein in Chinese adults: an observational study.	Fatty Acids, Unsaturated	58-85	C-reactive protein	Homo sapiens	113-131
21569316-7	2011	CONCLUSIONS: Medium chain and unsaturated fatty acids are strongly influenced by polymorphisms in DGAT1 and SCD1.	Fatty Acids, Unsaturated	30-53	diacylglycerol O-acyltransferase 1	Bos taurus	98-103
21421544-3	2011	Previous studies have shown that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) dampen inflammation in the liver and decrease formation of tumor necrosis factor (TNF)-alpha.	Fatty Acids, Unsaturated	76-81	tumor necrosis factor	Mus musculus	142-175
21421544-8	2011	Lipidomics analyses of lipid mediators revealed significantly increased levels of the n-3 PUFA-derived 18-hydroxyeicosapentaenoic acid (18-HEPE) and 17-hydroxydocosahexaenoic acid (17-HDHA) in the livers of fat-1 animals treated with DEN.	Fatty Acids, Unsaturated	90-94	FAT atypical cadherin 1	Mus musculus	207-212
21377536-6	2011	Additionally, salmon Elovl4 effectively converted C20 and C22 polyunsaturated fatty acids to elongated polyenoic products up to C36.	Fatty Acids, Unsaturated	62-89	elongation of very long chain fatty acids-like 4	Salmo salar	21-27
21360038-9	2011	The block by unsaturated fatty acids reported here opens the possibility that increases in the concentration of these lipids in the lens induce cataract formation by blocking Cx46 hemichannels.	Fatty Acids, Unsaturated	13-36	gap junction protein alpha 3 L homeolog	Xenopus laevis	175-179
21458237-0	2011	Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression.	Fatty Acids, Unsaturated	53-79	fatty acid desaturase 2	Rattus norvegicus	126-143
20676935-0	2011	Cytochrome b5 null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis.	Fatty Acids, Unsaturated	92-115	cytochrome b5 type A (microsomal)	Mus musculus	0-13
20676935-6	2011	In addition to these previously identified roles for this protein, cytochrome b (5) null mice displayed skin defects closely resembling those observed in autosomal recessive congenital ichthyosis and retardation of neonatal development, indicating that this protein, possibly as a consequence of its role in the de novo biosynthesis of unsaturated fatty acids, plays a central role in skin development and neonatal nutrition.	Fatty Acids, Unsaturated	336-359	cytochrome b, mitochondrial	Mus musculus	67-79
21569316-7	2011	CONCLUSIONS: Medium chain and unsaturated fatty acids are strongly influenced by polymorphisms in DGAT1 and SCD1.	Fatty Acids, Unsaturated	30-53	stearoyl-CoA desaturase	Bos taurus	108-112
21325103-12	2011	Unsaturated fatty acids induced time-dependent expression of FGF21 mRNA in human hepatocytes.	Fatty Acids, Unsaturated	0-23	fibroblast growth factor 21	Homo sapiens	61-66
21187320-3	2011	In particular, the functions of the cytochrome P450 (CYP) metabolites of n-3 PUFAs remain virtually unexplored.	Fatty Acids, Unsaturated	77-82	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-51
21187320-3	2011	In particular, the functions of the cytochrome P450 (CYP) metabolites of n-3 PUFAs remain virtually unexplored.	Fatty Acids, Unsaturated	77-82	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	53-56
21328367-13	2011	Furthermore, the snail lipidic fraction contains high proportions of polyunsaturated fatty acids benefical for human health.	Fatty Acids, Unsaturated	69-96	snail family transcriptional repressor 1	Homo sapiens	17-22
21075183-4	2011	It was found that compounds esterified with unsaturated fatty acids demonstrated significant COX-2 inhibitory effects, while in the COX-1 assay only 14-benzoylaconine-8-O-eicosapentaenoate exerted remarkable activity.	Fatty Acids, Unsaturated	44-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
21513558-0	2011	Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study.	Fatty Acids, Unsaturated	110-136	stearoyl-CoA desaturase	Homo sapiens	0-21
21513558-0	2011	Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study.	Fatty Acids, Unsaturated	110-136	stearoyl-CoA desaturase	Homo sapiens	23-27
21513558-1	2011	BACKGROUND: We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men.	Fatty Acids, Unsaturated	168-194	stearoyl-CoA desaturase	Homo sapiens	53-74
21513558-1	2011	BACKGROUND: We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men.	Fatty Acids, Unsaturated	168-194	stearoyl-CoA desaturase	Homo sapiens	76-80
21513558-1	2011	BACKGROUND: We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men.	Fatty Acids, Unsaturated	168-194	insulin	Homo sapiens	105-112
21161262-10	2011	When compared to the balanced diet, the n-3 PUFA-deficient diet induced an increase in the LG transcript levels of IL-6 for the control animals and of TNF-alpha for the control and dry eye animals as well as an increase in the conjunctival transcript levels of IL-6 for the dry eye animals.	Fatty Acids, Unsaturated	44-48	interleukin 6	Rattus norvegicus	115-119
21161262-10	2011	When compared to the balanced diet, the n-3 PUFA-deficient diet induced an increase in the LG transcript levels of IL-6 for the control animals and of TNF-alpha for the control and dry eye animals as well as an increase in the conjunctival transcript levels of IL-6 for the dry eye animals.	Fatty Acids, Unsaturated	44-48	tumor necrosis factor	Rattus norvegicus	151-160
21161262-10	2011	When compared to the balanced diet, the n-3 PUFA-deficient diet induced an increase in the LG transcript levels of IL-6 for the control animals and of TNF-alpha for the control and dry eye animals as well as an increase in the conjunctival transcript levels of IL-6 for the dry eye animals.	Fatty Acids, Unsaturated	44-48	interleukin 6	Rattus norvegicus	261-265
21270364-0	2011	Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in puerto rican adults.	Fatty Acids, Unsaturated	123-150	methylenetetrahydrofolate reductase	Homo sapiens	0-35
21266583-5	2011	Proteolytic activation of sPLA(2)-X in PLA2G10-Tg skin was accompanied by preferential hydrolysis of phosphatidylethanolamine species with polyunsaturated fatty acids as well as elevated production of some if not all eicosanoids.	Fatty Acids, Unsaturated	139-166	phospholipase A2, group X	Mus musculus	26-35
21266583-5	2011	Proteolytic activation of sPLA(2)-X in PLA2G10-Tg skin was accompanied by preferential hydrolysis of phosphatidylethanolamine species with polyunsaturated fatty acids as well as elevated production of some if not all eicosanoids.	Fatty Acids, Unsaturated	139-166	phospholipase A2, group X	Mus musculus	39-46
21530801-0	2011	Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	50-85
21366865-6	2011	Mechanisms by which FADS SNPs modulate PUFA levels in blood, breast milk and tissues should be explored further.	Fatty Acids, Unsaturated	39-43	stearoyl-CoA desaturase	Homo sapiens	20-24
21530801-7	2011	Unsaturated fatty acids decreased ABCA1 protein levels at 100 mumol/L of concentration regardless of the agonist with a minimal effect on messenger RNA abundance.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	34-39
21530801-10	2011	In conclusion, our results indicate that unsaturated fatty acids regulate ABCA1 expression in HepG2 and FHs 74 Int cells at the posttranscriptional level and PKCdelta is likely to be involved in maintaining ABCA1 protein levels.	Fatty Acids, Unsaturated	41-64	ATP binding cassette subfamily A member 1	Homo sapiens	74-79
21184048-9	2011	The QTL indicate the presence of 13 loci with novel alleles inherited from the progenitors of the resynthesised B. napus that might be useful for modulating the content or extent of desaturation of polyunsaturated fatty acids, only one of which coincides with the anticipated position of a candidate gene, an orthologue of FAD2.	Fatty Acids, Unsaturated	198-225	omega-6 fatty acid desaturase, endoplasmic reticulum	Brassica napus	323-327
20532624-2	2011	Transgenic female mice expressing the Fat-1 gene under transcriptional control of the goat beta-casein promoter produce milk phospholipids having elevated levels of n-3 polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	198-202	FAT atypical cadherin 1	Mus musculus	38-43
21209459-6	2011	We explored the consequences of the changes of ALDRP expression levels on the fatty acid content (saturated, monounsaturated, and polyunsaturated fatty acids) in phospholipids as well as on the levels of beta-oxidation of 3 suspected substrates: C26:0, C24:0, and C22:6n-3 (DHA).	Fatty Acids, Unsaturated	130-157	ATP binding cassette subfamily D member 2	Homo sapiens	47-52
21178610-6	2011	Moreover, loss-of-function and gain-of-function studies have identified fatty acid elongase (Elovl5), a key enzyme involved in PUFA synthesis, as a regulator of hepatic lipid and carbohydrate metabolism.	Fatty Acids, Unsaturated	127-131	ELOVL family member 5, elongation of long chain fatty acids (yeast)	Mus musculus	93-99
21133892-5	2011	KEY RESULTS: A variety of polyunsaturated fatty acids with chain lengths between C18-C22 attenuated the cytotoxic actions of the saturated fatty acid, palmitate (C16:0) in BRIN-BD11 and INS-1 cells.	Fatty Acids, Unsaturated	26-53	insulin 1	Rattus norvegicus	186-191
21217086-2	2011	METHODS: We investigated associations between serum polyunsaturated fatty acid concentrations and p53 expression in normal skin, as a biomarker of early UV-induced carcinogenesis, in an unselected sample of Australian adults.	Fatty Acids, Unsaturated	52-78	tumor protein p53	Homo sapiens	98-101
20697415-1	2011	OBJECTIVE: Arachidonate 12-lipoxygenase (ALOX12) is a member of the lipoxygenase superfamily, which catalyzes the incorporation of molecular oxygen into polyunsaturated fatty acids.	Fatty Acids, Unsaturated	153-180	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	11-39
20697415-1	2011	OBJECTIVE: Arachidonate 12-lipoxygenase (ALOX12) is a member of the lipoxygenase superfamily, which catalyzes the incorporation of molecular oxygen into polyunsaturated fatty acids.	Fatty Acids, Unsaturated	153-180	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	41-47
20725866-3	2011	Furthermore, alpha-syn interacts with polyunsaturated fatty acids, and this interaction may promote the oligomerization process.	Fatty Acids, Unsaturated	38-65	synuclein alpha	Homo sapiens	13-22
21093950-9	2011	CONCLUSIONS: The fatty acid enzyme, delta-9 desaturase, was activated by HCV core protein and polyunsaturated fatty acids counteracted this impact of the core protein on lipid metabolism.	Fatty Acids, Unsaturated	94-121	fatty acid desaturase 3	Homo sapiens	36-54
21149645-5	2011	The presence of PCs containing polyunsaturated fatty acids in the OS layer implied that these phospholipids form flexible lipid bilayers, which facilitate phototransduction process occurring in the rhodopsin rich OS layer.	Fatty Acids, Unsaturated	31-58	rhodopsin	Homo sapiens	198-207
21358271-5	2011	Moreover, the tgd1-1 fad6 and tgd4-3 fad6 double mutants were deficient in polyunsaturated fatty acids in chloroplast membrane lipids, and severely compromised in the biogenesis of photosynthetic membrane systems.	Fatty Acids, Unsaturated	75-102	fatty acid desaturase 6	Arabidopsis thaliana	21-25
21205621-0	2011	Nonsymbiotic hemoglobin-2 leads to an elevated energy state and to a combined increase in polyunsaturated fatty acids and total oil content when overexpressed in developing seeds of transgenic Arabidopsis plants.	Fatty Acids, Unsaturated	90-117	hemoglobin 2	Arabidopsis thaliana	13-25
21358271-5	2011	Moreover, the tgd1-1 fad6 and tgd4-3 fad6 double mutants were deficient in polyunsaturated fatty acids in chloroplast membrane lipids, and severely compromised in the biogenesis of photosynthetic membrane systems.	Fatty Acids, Unsaturated	75-102	fatty acid desaturase 6	Arabidopsis thaliana	37-41
21147856-2	2011	In addition to maternal nutrition as an important regulator of FA concentrations, first results exist on an association of breast-milk FAs with single nucleotide polymorphisms (SNPs) in the FADS gene cluster, which encodes the rate-limiting enzymes in the elongation-desaturation pathway of long-chain polyunsaturated fatty acids (LC-PUFAs).	Fatty Acids, Unsaturated	302-329	receptor associated protein of the synapse	Homo sapiens	190-194
21070866-1	2011	BACKGROUND: Dietary n-3 polyunsaturated fatty acid (PUFA) deprivation increases expression of arachidonic acid (AA 20:4n-6)-selective cytosolic phospholipase A(2) (cPLA(2)) IVA and cyclooxygenase (COX)-2 in rat brain, while decreasing expression of docosahexaenoic acid (DHA 22:6n-3)-selective calcium-independent iPLA(2) VIA.	Fatty Acids, Unsaturated	52-56	phospholipase A2 group IVA	Rattus norvegicus	134-171
21070866-1	2011	BACKGROUND: Dietary n-3 polyunsaturated fatty acid (PUFA) deprivation increases expression of arachidonic acid (AA 20:4n-6)-selective cytosolic phospholipase A(2) (cPLA(2)) IVA and cyclooxygenase (COX)-2 in rat brain, while decreasing expression of docosahexaenoic acid (DHA 22:6n-3)-selective calcium-independent iPLA(2) VIA.	Fatty Acids, Unsaturated	52-56	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	181-203
21112644-16	2011	When stepwise multiple regression analysis was performed considering each mRNA as a dependent variable and change in selected individual and summed fatty acid concentrations as independent variables, change in the ratio of saturated fatty acids (SFA) to polyunsaturated fatty acids (PUFA) was significant (P&lt;=0.05) in the mRNA regression analyses for IL-8R, ICE, MPO, and cyclooxygenase-2.	Fatty Acids, Unsaturated	254-281	caspase-1	Canis lupus familiaris	361-364
21112644-16	2011	When stepwise multiple regression analysis was performed considering each mRNA as a dependent variable and change in selected individual and summed fatty acid concentrations as independent variables, change in the ratio of saturated fatty acids (SFA) to polyunsaturated fatty acids (PUFA) was significant (P&lt;=0.05) in the mRNA regression analyses for IL-8R, ICE, MPO, and cyclooxygenase-2.	Fatty Acids, Unsaturated	254-281	myeloperoxidase	Canis lupus familiaris	366-369
21112644-16	2011	When stepwise multiple regression analysis was performed considering each mRNA as a dependent variable and change in selected individual and summed fatty acid concentrations as independent variables, change in the ratio of saturated fatty acids (SFA) to polyunsaturated fatty acids (PUFA) was significant (P&lt;=0.05) in the mRNA regression analyses for IL-8R, ICE, MPO, and cyclooxygenase-2.	Fatty Acids, Unsaturated	254-281	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	375-391
21112644-16	2011	When stepwise multiple regression analysis was performed considering each mRNA as a dependent variable and change in selected individual and summed fatty acid concentrations as independent variables, change in the ratio of saturated fatty acids (SFA) to polyunsaturated fatty acids (PUFA) was significant (P&lt;=0.05) in the mRNA regression analyses for IL-8R, ICE, MPO, and cyclooxygenase-2.	Fatty Acids, Unsaturated	283-287	caspase-1	Canis lupus familiaris	361-364
21112644-16	2011	When stepwise multiple regression analysis was performed considering each mRNA as a dependent variable and change in selected individual and summed fatty acid concentrations as independent variables, change in the ratio of saturated fatty acids (SFA) to polyunsaturated fatty acids (PUFA) was significant (P&lt;=0.05) in the mRNA regression analyses for IL-8R, ICE, MPO, and cyclooxygenase-2.	Fatty Acids, Unsaturated	283-287	myeloperoxidase	Canis lupus familiaris	366-369
21112644-16	2011	When stepwise multiple regression analysis was performed considering each mRNA as a dependent variable and change in selected individual and summed fatty acid concentrations as independent variables, change in the ratio of saturated fatty acids (SFA) to polyunsaturated fatty acids (PUFA) was significant (P&lt;=0.05) in the mRNA regression analyses for IL-8R, ICE, MPO, and cyclooxygenase-2.	Fatty Acids, Unsaturated	283-287	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	375-391
20814411-2	2011	Our objective was to investigate the effect of long-chain n-3 polyunsaturated fatty acids (PUFAs) on adiponectin in cultured human adipocytes, and to elucidate the role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in this regulation.	Fatty Acids, Unsaturated	91-96	adiponectin, C1Q and collagen domain containing	Homo sapiens	101-112
20970313-3	2011	Polyunsaturated fatty acids (PUFA) are potential ligands for PPARgamma.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor gamma	Mus musculus	61-70
20970313-3	2011	Polyunsaturated fatty acids (PUFA) are potential ligands for PPARgamma.	Fatty Acids, Unsaturated	29-33	peroxisome proliferator activated receptor gamma	Mus musculus	61-70
20970313-4	2011	The current experiment was designed to determine the potential for PUFA, particularly eicosapentaenoic acid and docosahexaenoic acid, to activate the function of porcine PPARgamma in vivo.	Fatty Acids, Unsaturated	67-71	peroxisome proliferator activated receptor gamma	Mus musculus	170-179
20615514-7	2011	These preliminary findings demonstrate that FADS2 mRNA expression is significantly and selectively elevated in the prefrontal cortex of BD patients, and may contribute to dysregulated central PUFA biosynthesis and pro-inflammatory signaling implicated in the pathophysiology of BD.	Fatty Acids, Unsaturated	192-196	fatty acid desaturase 2	Homo sapiens	44-49
21169224-5	2011	Both PUFA-enriched remnants and nonesterified PUFA inhibited the expression and maturation of sterol response element binding protein-1c (SREBP-1c) and the expression of lipogenic genes regulated by this transcription factor.	Fatty Acids, Unsaturated	5-9	sterol regulatory element binding transcription factor 1	Rattus norvegicus	94-136
21169224-5	2011	Both PUFA-enriched remnants and nonesterified PUFA inhibited the expression and maturation of sterol response element binding protein-1c (SREBP-1c) and the expression of lipogenic genes regulated by this transcription factor.	Fatty Acids, Unsaturated	5-9	sterol regulatory element binding transcription factor 1	Rattus norvegicus	138-146
21107868-7	2011	In contrast, polyunsaturated fatty acids with 16 carbon atoms, which are synthesized exclusively by phytoplankton, but are not essential for animals, had significantly lower transfer efficiency than both bulk carbon, and essential PUFA.	Fatty Acids, Unsaturated	13-40	pumilio RNA binding family member 3	Homo sapiens	231-235
20456666-5	2011	Surprisingly, the percentage of polyunsaturated fatty acids was positively correlated with sperm quality and a low propensity for LPO, probably because these particular fatty acids provide a higher fluidity of the plasma membrane.	Fatty Acids, Unsaturated	32-59	lactoperoxidase	Homo sapiens	130-133
20869469-0	2011	Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	56-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	8-23
21244676-0	2011	Polyunsaturated fatty acids reduce fatty acid synthase and hydroxy-methyl-glutaryl CoA-reductase gene expression and promote apoptosis in HepG2 cell line.	Fatty Acids, Unsaturated	0-27	fatty acid synthase	Homo sapiens	35-54
21910087-7	2011	SREBP is inhibited by its end products cholesterol and unsaturated fatty acids.	Fatty Acids, Unsaturated	55-78	Sterol regulatory element binding protein	Drosophila melanogaster	0-5
20713121-8	2011	We also describe how nutrients especially polyunsaturated fatty acids and carbohydrates modulate SCD1 gene expression.	Fatty Acids, Unsaturated	42-69	stearoyl-CoA desaturase	Homo sapiens	97-101
21040914-1	2011	OBJECTIVE: We investigated the association of polymorphisms in FADS genes with polyunsaturated fatty acids (PUFAs) in serum phospholipids, lipid peroxides, and coronary artery disease (CAD) in Koreans.	Fatty Acids, Unsaturated	79-106	muscle associated receptor tyrosine kinase	Homo sapiens	63-67
21040914-1	2011	OBJECTIVE: We investigated the association of polymorphisms in FADS genes with polyunsaturated fatty acids (PUFAs) in serum phospholipids, lipid peroxides, and coronary artery disease (CAD) in Koreans.	Fatty Acids, Unsaturated	108-113	muscle associated receptor tyrosine kinase	Homo sapiens	63-67
20869469-2	2011	As discussed in the present review, virtually all of the major AA metabolizing CYP isoforms accept a variety of other polyunsaturated fatty acids (PUFA), including linoleic, eicosapentaenoic (EPA) and docosahexaenoic acids (DHA), as efficient alternative substrates.	Fatty Acids, Unsaturated	118-145	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-82
20869469-2	2011	As discussed in the present review, virtually all of the major AA metabolizing CYP isoforms accept a variety of other polyunsaturated fatty acids (PUFA), including linoleic, eicosapentaenoic (EPA) and docosahexaenoic acids (DHA), as efficient alternative substrates.	Fatty Acids, Unsaturated	147-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-82
21691070-0	2011	Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic beta-cells: activation of caspases and ER stress induction.	Fatty Acids, Unsaturated	21-44	caspase 2	Homo sapiens	133-141
20974817-4	2011	We found that the deletion of OLE1 resulted in an auxotrophic yeast strain (designated OLE1 KO) that required unsaturated fatty acids for growth but not saturated fatty acids.	Fatty Acids, Unsaturated	110-133	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	30-34
25324899-4	2011	It is caused by a mutation in the elongation of very-long-chain fatty acids-like 4 (ELOVL4) gene, which is responsible for encoding the elongase enzyme that converts shorter chain fatty acids into C28-C38 very long-chain polyunsaturated fatty acids (VLCPUFAs, total number of carbons &gt;=24).	Fatty Acids, Unsaturated	221-248	ELOVL fatty acid elongase 4	Homo sapiens	34-82
25324899-4	2011	It is caused by a mutation in the elongation of very-long-chain fatty acids-like 4 (ELOVL4) gene, which is responsible for encoding the elongase enzyme that converts shorter chain fatty acids into C28-C38 very long-chain polyunsaturated fatty acids (VLCPUFAs, total number of carbons &gt;=24).	Fatty Acids, Unsaturated	221-248	ELOVL fatty acid elongase 4	Homo sapiens	84-90
25324899-5	2011	Diets rich in long-chain polyunsaturated fatty acids (LCPUFAs) have inverse associations with the progression of AMD and STGD3, and a deficiency in retinal LCPUFAs and VLCPUFAs has been detected in AMD retinas and STGD3 animal models.	Fatty Acids, Unsaturated	25-52	ELOVL fatty acid elongase 4	Homo sapiens	121-126
20974817-4	2011	We found that the deletion of OLE1 resulted in an auxotrophic yeast strain (designated OLE1 KO) that required unsaturated fatty acids for growth but not saturated fatty acids.	Fatty Acids, Unsaturated	110-133	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	87-91
20974817-5	2011	Additionally, the production of UFA by OLE1 KO yeast cells was markedly reduced, suggesting that Ole1 is essential for UFA production.	Fatty Acids, Unsaturated	32-35	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	39-43
20974817-5	2011	Additionally, the production of UFA by OLE1 KO yeast cells was markedly reduced, suggesting that Ole1 is essential for UFA production.	Fatty Acids, Unsaturated	32-35	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	97-101
20974817-5	2011	Additionally, the production of UFA by OLE1 KO yeast cells was markedly reduced, suggesting that Ole1 is essential for UFA production.	Fatty Acids, Unsaturated	119-122	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	39-43
20974817-5	2011	Additionally, the production of UFA by OLE1 KO yeast cells was markedly reduced, suggesting that Ole1 is essential for UFA production.	Fatty Acids, Unsaturated	119-122	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	97-101
20974817-6	2011	In contrast to wild-type C. parapsilosis, which produced pseudohyphal growth on UFA-supplemented medium agar, pseudohyphal formation in the OLE1 KO cells was severely impaired, suggesting that Ole1 regulates morphology.	Fatty Acids, Unsaturated	80-83	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	193-197
20974817-8	2011	The results indicate that OLE1 is essential for the stress response, perhaps through the production of UFA for cell membrane biosynthesis.	Fatty Acids, Unsaturated	103-106	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	26-30
20974817-12	2011	Taken together, these results demonstrate that Ole1 regulates the pathobiology of C. parapsilosis via UFA and that the OLE1 pathway is a promising antifungal target.	Fatty Acids, Unsaturated	102-105	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	47-51
21606626-0	2011	Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: implication of fatty acid-binding proteins (FABP) and G protein-coupled receptor 40 (GPR40) in adult neurogenesis.	Fatty Acids, Unsaturated	44-71	free fatty acid receptor 1	Homo sapiens	153-182
21606626-0	2011	Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: implication of fatty acid-binding proteins (FABP) and G protein-coupled receptor 40 (GPR40) in adult neurogenesis.	Fatty Acids, Unsaturated	44-71	free fatty acid receptor 1	Homo sapiens	184-189
20938723-3	2011	In control and sedentary rats, diets enriched with saturated, monounsaturated, and polyunsaturated fatty acids (PUFA) enhanced the expression of the PPARalpha target genes carnitine palmitoyltransferase 1 and acyl-CoA oxidase, the highest effect being exerted by omega-3.	Fatty Acids, Unsaturated	83-110	peroxisome proliferator activated receptor alpha	Rattus norvegicus	149-158
20648548-3	2011	DHA, EPA, and AA down-regulated mRNAs and encoded proteins of stearoyl-CoA desaturase (SCD) and sterol regulatory element binding protein (SREBP-1c), two major factors involved in unsaturated fatty acids synthesis.	Fatty Acids, Unsaturated	180-203	stearoyl-CoA desaturase	Homo sapiens	62-85
20648548-3	2011	DHA, EPA, and AA down-regulated mRNAs and encoded proteins of stearoyl-CoA desaturase (SCD) and sterol regulatory element binding protein (SREBP-1c), two major factors involved in unsaturated fatty acids synthesis.	Fatty Acids, Unsaturated	180-203	stearoyl-CoA desaturase	Homo sapiens	87-90
20648548-3	2011	DHA, EPA, and AA down-regulated mRNAs and encoded proteins of stearoyl-CoA desaturase (SCD) and sterol regulatory element binding protein (SREBP-1c), two major factors involved in unsaturated fatty acids synthesis.	Fatty Acids, Unsaturated	180-203	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	96-137
20648548-3	2011	DHA, EPA, and AA down-regulated mRNAs and encoded proteins of stearoyl-CoA desaturase (SCD) and sterol regulatory element binding protein (SREBP-1c), two major factors involved in unsaturated fatty acids synthesis.	Fatty Acids, Unsaturated	180-203	sterol regulatory element binding transcription factor 1	Homo sapiens	139-147
21175770-4	2011	The present authors have previously demonstrated that antigens chemically coupled to the surface of liposomes made using unsaturated fatty acids are cross-presented by APCs via MHC class I to CD8(+) T cells and induce antigen-specific CTLs.	Fatty Acids, Unsaturated	121-144	amyloid P component, serum	Homo sapiens	168-172
21175770-4	2011	The present authors have previously demonstrated that antigens chemically coupled to the surface of liposomes made using unsaturated fatty acids are cross-presented by APCs via MHC class I to CD8(+) T cells and induce antigen-specific CTLs.	Fatty Acids, Unsaturated	121-144	CD8a molecule	Homo sapiens	192-195
20938723-3	2011	In control and sedentary rats, diets enriched with saturated, monounsaturated, and polyunsaturated fatty acids (PUFA) enhanced the expression of the PPARalpha target genes carnitine palmitoyltransferase 1 and acyl-CoA oxidase, the highest effect being exerted by omega-3.	Fatty Acids, Unsaturated	112-116	peroxisome proliferator activated receptor alpha	Rattus norvegicus	149-158
20094820-8	2011	RESULTS: A reduction in total saturated fatty acids (SFA), the n-6 family of polyunsaturated fatty acids (PUFA) and the n-6/n-3 PUFA ratio was observed after DHEA-S treatment, whereas monounsaturated fatty acids (MUFA) increased.	Fatty Acids, Unsaturated	77-104	sulfotransferase family 2A member 1	Homo sapiens	158-164
20094820-8	2011	RESULTS: A reduction in total saturated fatty acids (SFA), the n-6 family of polyunsaturated fatty acids (PUFA) and the n-6/n-3 PUFA ratio was observed after DHEA-S treatment, whereas monounsaturated fatty acids (MUFA) increased.	Fatty Acids, Unsaturated	106-110	sulfotransferase family 2A member 1	Homo sapiens	158-164
21241168-6	2011	Among the eicosanoids and oxidized polyunsaturated fatty acids (n = 17) a pronounced increase in arachidonic acid and its metabolite 12S-HETE was observed in MDA-MB-231 and to a lesser extent in MCF-7 cells, indicating release from cell membrane phospholipids upon activation of phospholipase A2 and subsequent metabolism by 12-lipoxygenase.	Fatty Acids, Unsaturated	35-62	phospholipase A2 group IB	Homo sapiens	279-295
22216341-9	2011	Rat Elovl2 was active with C(20) and C(22) polyunsaturated fatty acids and this single enzyme catalysed the sequential elongation reactions of EPA DPA 24:5n-3.	Fatty Acids, Unsaturated	41-70	ELOVL fatty acid elongase 2	Rattus norvegicus	4-10
20655950-2	2011	Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays unique properties, thus making their role in inflammation distinct from that of other lipids derived from the same PUFA.	Fatty Acids, Unsaturated	13-40	pumilio RNA binding family member 3	Homo sapiens	42-46
22140540-1	2011	BACKGROUND: Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon polyunsaturated fatty acids (PUFA) that are direct eicosanoid precursors.	Fatty Acids, Unsaturated	198-202	fatty acid desaturase 1	Homo sapiens	57-62
22140540-6	2011	CONCLUSIONS/SIGNIFICANCE: The loss of FADS2-encoded activities in cancer cells shuts down normal PUFA biosynthesis, deleting the endogenous supply of eicosanoid and downstream docosanoid precursors, and replacing them with unusual butylene-interrupted fatty acids.	Fatty Acids, Unsaturated	97-101	fatty acid desaturase 2	Homo sapiens	38-43
21712952-6	2011	paqr-2 is the most important of the three paqr genes: mutants grow poorly, fail to adapt to growth at low temperature, and have a very high fat content with an abnormal enrichment in long (C20) poly-unsaturated fatty acids when combined with the paqr-1 mutation.	Fatty Acids, Unsaturated	194-222	Progestin and AdipoQ Receptor family	Caenorhabditis elegans	0-6
21045166-7	2011	PUFA-enriched serum and albumin increased the yield of morphologically poorer quality blastocysts with increased transcript expression for the antioxidant enzyme SOD1.	Fatty Acids, Unsaturated	0-4	superoxide dismutase 1	Homo sapiens	162-166
21516670-1	2011	Several observational and experimental studies have proved polyunsaturated fatty acids N-3 (N-3 PUFA) beneficial effects.The first to be detected was the ipolipidic effect so these drugs have been used for the treatment of dislipidemic disorders, while antinflammatory, antithrombotic and antiarrhythmogenic effects have been found later.	Fatty Acids, Unsaturated	59-86	pumilio RNA binding family member 3	Homo sapiens	96-100
22232878-5	2011	Marker of the apoB-100 receptor breach of transfer low-density lipoprotein, transporting polyunsaturated fatty acids was to increase LDL cholesterol in serum.	Fatty Acids, Unsaturated	89-116	apolipoprotein B	Rattus norvegicus	14-22
20921226-0	2010	Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.	Fatty Acids, Unsaturated	142-169	arachidonate lipoxygenase 3	Homo sapiens	24-48
21151462-0	2010	Polyunsaturated fatty acids and modulation of cholesterol homeostasis in THP-1 macrophage-derived foam cells.	Fatty Acids, Unsaturated	0-27	GLI family zinc finger 2	Homo sapiens	73-78
21075079-1	2010	The SaccharomycescerevisiaeMGA2 gene encodes an important regulator of unsaturated fatty acid production, by controlling transcription and mRNA stability of OLE1, the gene encoding the Delta9 fatty acid desaturase.	Fatty Acids, Unsaturated	71-93	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	157-161
21075079-5	2010	We report here that in addition to MGA2"s role in regulation of unsaturated fatty acids, MGA2 is required for full basal expression of ERG1.	Fatty Acids, Unsaturated	64-87	Mga2p	Saccharomyces cerevisiae S288C	35-39
21075079-5	2010	We report here that in addition to MGA2"s role in regulation of unsaturated fatty acids, MGA2 is required for full basal expression of ERG1.	Fatty Acids, Unsaturated	64-87	squalene monooxygenase	Saccharomyces cerevisiae S288C	135-139
21179411-1	2010	We have previously demonstrated that antigens chemically coupled to the surface of liposomes consisting of unsaturated fatty acids were cross-presented by antigen-presenting cells (APCs) to CD8+ T cells, and that this process resulted in the induction of antigen-specific cytotoxic T lymphocytes.	Fatty Acids, Unsaturated	107-130	CD8a molecule	Homo sapiens	190-193
21179411-8	2010	These results suggest that antigens coupled to the surface of liposomes consisting of unsaturated fatty acids might be pinocytosed by APCs, loaded onto the class I MHC processing pathway, and presented to CD8+ T cells.	Fatty Acids, Unsaturated	86-109	CD8a molecule	Homo sapiens	205-208
21115839-0	2010	Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis.	Fatty Acids, Unsaturated	48-71	Fas associated factor family member 2	Homo sapiens	18-23
20831192-0	2010	Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid.	Fatty Acids, Unsaturated	88-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	8-12
20831192-1	2010	This study is to investigate the role of Nrf2 in suppressing LPS-mediated inflammation in ex vivo macrophages by polyunsaturated fatty acids (PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).	Fatty Acids, Unsaturated	113-140	nuclear factor, erythroid derived 2, like 2	Mus musculus	41-45
20831192-1	2010	This study is to investigate the role of Nrf2 in suppressing LPS-mediated inflammation in ex vivo macrophages by polyunsaturated fatty acids (PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).	Fatty Acids, Unsaturated	142-146	nuclear factor, erythroid derived 2, like 2	Mus musculus	41-45
20705908-0	2010	Role of lysophosphatidic acid acyltransferase 3 for the supply of highly polyunsaturated fatty acids in TM4 Sertoli cells.	Fatty Acids, Unsaturated	73-100	1-acylglycerol-3-phosphate O-acyltransferase 3	Mus musculus	8-47
19819120-3	2010	Therefore, the aim of this study was to evaluate the association of six ADAM17 single nucleotide polymorphisms (SNPs) (m1254A&gt;G, i14121C&gt;A, i33708A&gt;G, i48827A&gt;C, i53440C&gt;T, and i62781G&gt;T) with insulin-resistance phenotypes and obesity risk, and their potential interactions with dietary polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	305-332	ADAM metallopeptidase domain 17	Homo sapiens	72-78
19819120-3	2010	Therefore, the aim of this study was to evaluate the association of six ADAM17 single nucleotide polymorphisms (SNPs) (m1254A&gt;G, i14121C&gt;A, i33708A&gt;G, i48827A&gt;C, i53440C&gt;T, and i62781G&gt;T) with insulin-resistance phenotypes and obesity risk, and their potential interactions with dietary polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	334-338	ADAM metallopeptidase domain 17	Homo sapiens	72-78
20570249-3	2010	12/15 Lipoxygenase (12/15LO) by oxidizing polyunsaturated fatty acids forms hydroperoxyacids, which are potent pro-oxidants and inflammatory mediators.	Fatty Acids, Unsaturated	42-69	arachidonate 15-lipoxygenase	Mus musculus	0-18
20693347-7	2010	Under hyperinsulinemic-euglycemic conditions, AMPKalpha2 was essential for preserving low levels of both hepatic and plasma triglycerides, as well as plasma free fatty acids, in response to the n-3 LC-PUFA treatment.	Fatty Acids, Unsaturated	201-205	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	46-56
21059219-0	2010	Neutrophil unsaturated fatty acid release by GM-CSF is impaired in cystic fibrosis.	Fatty Acids, Unsaturated	11-33	colony stimulating factor 2	Homo sapiens	45-51
20622181-0	2010	Regulation of the expression of angiotensin-converting enzyme 2 by polyunsaturated fatty acids in porcine adipocytes.	Fatty Acids, Unsaturated	67-94	angiotensin converting enzyme 2	Sus scrofa	32-63
20647030-2	2010	Based on our observation of aberrant myeloid cell representation in hematopoietic tissues of 12/15-lipoxygenase (12/15-LOX)-deficient (Alox15) mice, we tested the hypothesis that polyunsaturated fatty acid metabolism regulates myelopoiesis.	Fatty Acids, Unsaturated	179-205	arachidonate 15-lipoxygenase	Mus musculus	93-111
20647030-2	2010	Based on our observation of aberrant myeloid cell representation in hematopoietic tissues of 12/15-lipoxygenase (12/15-LOX)-deficient (Alox15) mice, we tested the hypothesis that polyunsaturated fatty acid metabolism regulates myelopoiesis.	Fatty Acids, Unsaturated	179-205	arachidonate 15-lipoxygenase	Mus musculus	113-122
20647030-2	2010	Based on our observation of aberrant myeloid cell representation in hematopoietic tissues of 12/15-lipoxygenase (12/15-LOX)-deficient (Alox15) mice, we tested the hypothesis that polyunsaturated fatty acid metabolism regulates myelopoiesis.	Fatty Acids, Unsaturated	179-205	arachidonate 15-lipoxygenase	Mus musculus	135-141
20659784-6	2010	The H-FABP MspI RFLP genotype affected unsaturated fatty acid content, and the ratio of polyunsaturated fatty acid to saturated fatty acid (P&lt;0.05), whereas the H-FABP HaeIII RFLP genotype had no effect on fatty acid characteristics.	Fatty Acids, Unsaturated	39-61	fatty acid-binding protein, heart	Sus scrofa	4-10
20659784-6	2010	The H-FABP MspI RFLP genotype affected unsaturated fatty acid content, and the ratio of polyunsaturated fatty acid to saturated fatty acid (P&lt;0.05), whereas the H-FABP HaeIII RFLP genotype had no effect on fatty acid characteristics.	Fatty Acids, Unsaturated	88-114	fatty acid-binding protein, heart	Sus scrofa	4-10
20798165-0	2010	Diversity of caecal bacteria is altered in interleukin-10 gene-deficient mice before and after colitis onset and when fed polyunsaturated fatty acids.	Fatty Acids, Unsaturated	122-149	interleukin 10	Mus musculus	43-57
20948998-0	2010	Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.	Fatty Acids, Unsaturated	58-85	fatty acid desaturase 1	Homo sapiens	16-21
20798165-4	2010	We have previously shown that dietary n-3 and n-6 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects and affect colonic gene expression profiles in Il10(-/-) mice; therefore, we also aimed to test the effect of the n-3 PUFA eicosapentaenoic acid (EPA) and the n-6 PUFA arachidonic acid (AA) on the bacterial community of caeca in both Il10(-/-) and C57 mice fed these diets.	Fatty Acids, Unsaturated	79-83	interleukin 10	Mus musculus	163-167
20798165-4	2010	We have previously shown that dietary n-3 and n-6 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects and affect colonic gene expression profiles in Il10(-/-) mice; therefore, we also aimed to test the effect of the n-3 PUFA eicosapentaenoic acid (EPA) and the n-6 PUFA arachidonic acid (AA) on the bacterial community of caeca in both Il10(-/-) and C57 mice fed these diets.	Fatty Acids, Unsaturated	79-83	interleukin 10	Mus musculus	350-354
20932307-4	2010	Here, we report the effects of chronic feeding of different diets containing vanaspati (TFA rich), palm oil (SFA rich) and sunflower oil (PUFA rich) at 10%level on 11beta-HSD1 gene expression in rat retroperitoneal adipose tissue.	Fatty Acids, Unsaturated	138-142	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	164-175
20932307-5	2010	11beta-HSD1 gene expression was significantly higher in TFA rich diet-fed rats compared to SFA rich diet-fed rats, which in turn was significantly higher than PUFA rich diet-fed rats.	Fatty Acids, Unsaturated	159-163	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-11
20861226-3	2010	We show now that activation of PPARgamma by unsaturated fatty acids or thiazolidinediones drastically augments the cAMP-dependent increase of renin mRNA in the human renin-producing cell line Calu-6.	Fatty Acids, Unsaturated	44-67	peroxisome proliferator activated receptor gamma	Homo sapiens	31-40
20861226-3	2010	We show now that activation of PPARgamma by unsaturated fatty acids or thiazolidinediones drastically augments the cAMP-dependent increase of renin mRNA in the human renin-producing cell line Calu-6.	Fatty Acids, Unsaturated	44-67	renin	Homo sapiens	142-147
20861226-3	2010	We show now that activation of PPARgamma by unsaturated fatty acids or thiazolidinediones drastically augments the cAMP-dependent increase of renin mRNA in the human renin-producing cell line Calu-6.	Fatty Acids, Unsaturated	44-67	renin	Homo sapiens	166-171
20587751-0	2010	Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization.	Fatty Acids, Unsaturated	0-23	growth hormone secretagogue receptor	Homo sapiens	61-97
20930595-1	2010	Recent findings that a novel polyunsaturated fatty acid, beta-oxa 23:4n-6, inhibits adhesion molecule expression on vascular endothelial cells and leukocyte adhesion led us to examine its ability to inhibit the development of atherosclerosis in the apoE-deficient (apoE) mouse.	Fatty Acids, Unsaturated	29-55	apolipoprotein E	Mus musculus	249-253
20930595-1	2010	Recent findings that a novel polyunsaturated fatty acid, beta-oxa 23:4n-6, inhibits adhesion molecule expression on vascular endothelial cells and leukocyte adhesion led us to examine its ability to inhibit the development of atherosclerosis in the apoE-deficient (apoE) mouse.	Fatty Acids, Unsaturated	29-55	apolipoprotein E	Mus musculus	265-269
20230855-5	2010	Among the LPA receptors, LPA(3) is unique in that it is activated significantly by a specific form of LPA (2-acyl LPA with unsaturated fatty acids) and is expressed in a limited number of tissues such as the reproductive organs.	Fatty Acids, Unsaturated	123-146	lysophosphatidic acid receptor 3	Mus musculus	25-30
20634487-6	2010	Inhibition of PPARgamma also reverses the omega3-PUFA-induced reduction of retinal tumor necrosis factor-alpha, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelial selectin, and angiopoietin 2 but not vascular endothelial growth factor.	Fatty Acids, Unsaturated	49-53	peroxisome proliferator activated receptor gamma	Mus musculus	14-23
20688483-0	2010	Epimorphin-derived peptide antagonists remedy epidermal parakeratosis triggered by unsaturated fatty acid.	Fatty Acids, Unsaturated	83-105	syntaxin 2	Mus musculus	0-10
20688483-8	2010	CONCLUSIONS: The effects of unsaturated fatty acid are attributed to the overstimulation of epimorphin signaling and suggest the epimorphin antagonist as a possible therapeutic agent for acne and hyperkeratotic skin disease.	Fatty Acids, Unsaturated	28-50	syntaxin 2	Mus musculus	92-102
20688483-8	2010	CONCLUSIONS: The effects of unsaturated fatty acid are attributed to the overstimulation of epimorphin signaling and suggest the epimorphin antagonist as a possible therapeutic agent for acne and hyperkeratotic skin disease.	Fatty Acids, Unsaturated	28-50	syntaxin 2	Mus musculus	129-139
20601073-10	2010	In conclusion, this study showed that a PUFA supplementation with C18:2, C18:3 or C22:6 in bovine culture development for 6 days and co-culture with Boec down-regulate mRNA expression of proteins involved in lipid metabolism in d 7-8 embryo (SCD1 and FADS2 desaturases), probably through SREBP1 mRNA regulation after 10microM C22:6 supplementation, indicating a modification of saturated/unsaturated fatty acid balance in bovine blastocyst.	Fatty Acids, Unsaturated	388-410	PUFA	Bos taurus	40-44
20634487-6	2010	Inhibition of PPARgamma also reverses the omega3-PUFA-induced reduction of retinal tumor necrosis factor-alpha, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelial selectin, and angiopoietin 2 but not vascular endothelial growth factor.	Fatty Acids, Unsaturated	49-53	intercellular adhesion molecule 1	Mus musculus	112-145
20806040-2	2010	METHODS: Female transgenic mice expressing the VPP rhodopsin mutation, known to cause a retinal degeneration, were bred to male transgenic mice expressing the fat-1 gene, which can convert n6 to n3 polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	198-225	FAT atypical cadherin 1	Mus musculus	159-164
20806040-2	2010	METHODS: Female transgenic mice expressing the VPP rhodopsin mutation, known to cause a retinal degeneration, were bred to male transgenic mice expressing the fat-1 gene, which can convert n6 to n3 polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	227-231	FAT atypical cadherin 1	Mus musculus	159-164
20634487-6	2010	Inhibition of PPARgamma also reverses the omega3-PUFA-induced reduction of retinal tumor necrosis factor-alpha, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelial selectin, and angiopoietin 2 but not vascular endothelial growth factor.	Fatty Acids, Unsaturated	49-53	vascular cell adhesion molecule 1	Mus musculus	147-180
20634487-6	2010	Inhibition of PPARgamma also reverses the omega3-PUFA-induced reduction of retinal tumor necrosis factor-alpha, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelial selectin, and angiopoietin 2 but not vascular endothelial growth factor.	Fatty Acids, Unsaturated	49-53	angiopoietin 2	Mus musculus	208-222
20385201-0	2010	Suppression of ABCA1 by unsaturated fatty acids leads to lipid accumulation in HepG2 cells.	Fatty Acids, Unsaturated	24-47	ATP binding cassette subfamily A member 1	Homo sapiens	15-20
20512324-0	2010	Improvement of polyunsaturated fatty acids synthesis by the coexpression of CYB5 with desaturase genes in Saccharomyces cerevisiae.	Fatty Acids, Unsaturated	15-42	Cyb5p	Saccharomyces cerevisiae S288C	76-80
20385201-3	2010	We previously reported that unsaturated fatty acids destabilise ABCA1 in murine macrophages and ABCA1-transfected baby hamster kidney cells by increasing its protein degradation.	Fatty Acids, Unsaturated	28-51	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	64-69
20512324-4	2010	Without extra cytochrome b5, while PUFA synthesis is significant at low temperature (20 degrees C), it was marginal at 30 degrees C. Overexpression of cytochrome b5 at 20 degrees C did not affect the fatty acid synthesis so much, but it significantly enhanced the synthesis of PUFA at 30 degrees C.	Fatty Acids, Unsaturated	277-281	Cyb5p	Saccharomyces cerevisiae S288C	151-164
20116951-9	2010	In these patients hepatic UFA (ratio 1) correlated with AST/ALT ratio (r=-0.46, p=0.02), glucose levels (r=0.46, p=0.018), HOMA-IR (r=0.59, p=0.004) and HTGC (r=0.81, p&lt;0.001).	Fatty Acids, Unsaturated	26-29	solute carrier family 17 member 5	Homo sapiens	56-59
20573490-5	2010	A low PUFA (0.4%en) reference diet stimulated the expression of delta 6 desaturase (FADS2) and elongase 2 (ELOVL2) when compared to higher PUFA diets.	Fatty Acids, Unsaturated	6-10	fatty acid desaturase 2	Rattus norvegicus	64-82
20580946-0	2010	Impairment of NFkappaB activity by unsaturated fatty acids.	Fatty Acids, Unsaturated	35-58	nuclear factor kappa B subunit 1	Homo sapiens	14-22
20580946-1	2010	Using a luciferase reporter gene assay, we identified polyunsaturated fatty acids (PUFA) to impair NF kappaB signaling.	Fatty Acids, Unsaturated	54-81	nuclear factor kappa B subunit 1	Homo sapiens	99-108
20580946-1	2010	Using a luciferase reporter gene assay, we identified polyunsaturated fatty acids (PUFA) to impair NF kappaB signaling.	Fatty Acids, Unsaturated	83-87	nuclear factor kappa B subunit 1	Homo sapiens	99-108
20382866-8	2010	Using promoter-reporter gene (luciferase) constructs transfected into both HEK 293 and McA-RH7777 cells (kidney- and liver-derived cell lines, respectively), we showed the activity of the SCD promoter from 4 different species (mouse, human, pig, and sheep) to be reduced in a dose-dependent manner by addition of unsaturated fatty acids to the media, with linoleic acid being more potent than oleic acid after a 24-h treatment at 60 microM.	Fatty Acids, Unsaturated	313-336	stearoyl-CoA desaturase	Rattus norvegicus	188-191
20416832-6	2010	Diets rich in polyunsaturated FA (PUFA) did not reduce fat deposition in separable fat depots with respect to monounsaturated FA (MUFA) and saturated FA (SFA).	Fatty Acids, Unsaturated	14-32	Polyunsaturated fatty acid percentage	Sus scrofa	34-38
20580946-6	2010	According to our data dietary supplementation with PUFA-containing oils is likely to provide an at least palliative therapy for disorders linked to inappropriate NF kappaB signaling.	Fatty Acids, Unsaturated	51-55	nuclear factor kappa B subunit 1	Homo sapiens	162-171
20429043-5	2010	Tumour cells overexpressing Akt activity, including gliomas, are sensitised to ROS damage by the Akt protein and may be good targets for chemotherapeutic agents, which produce ROS, such as PUFAs.	Fatty Acids, Unsaturated	189-194	AKT serine/threonine kinase 1	Homo sapiens	28-31
20573490-5	2010	A low PUFA (0.4%en) reference diet stimulated the expression of delta 6 desaturase (FADS2) and elongase 2 (ELOVL2) when compared to higher PUFA diets.	Fatty Acids, Unsaturated	6-10	fatty acid desaturase 2	Rattus norvegicus	84-89
20573490-5	2010	A low PUFA (0.4%en) reference diet stimulated the expression of delta 6 desaturase (FADS2) and elongase 2 (ELOVL2) when compared to higher PUFA diets.	Fatty Acids, Unsaturated	6-10	ELOVL fatty acid elongase 2	Rattus norvegicus	107-113
20226839-0	2010	Polyunsaturated fatty acids are involved in regulatory mechanism of fatty acid homeostasis via daf-2/insulin signaling in Caenorhabditis elegans.	Fatty Acids, Unsaturated	0-27	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	95-100
20226839-4	2010	FAT-2 regulates the first step of polyunsaturated fatty acid (PUFA) synthesis.	Fatty Acids, Unsaturated	34-60	Delta(12) fatty acid desaturase fat-2	Caenorhabditis elegans	0-5
20226839-11	2010	Furthermore, treatment of the fat-2-RNAi worm with PUFA--using the fatty acids from linoleic acid through eicosapentaenoic acid--suppressed nuclear localization of DAF-16.	Fatty Acids, Unsaturated	51-55	Delta(12) fatty acid desaturase fat-2	Caenorhabditis elegans	30-35
20226839-4	2010	FAT-2 regulates the first step of polyunsaturated fatty acid (PUFA) synthesis.	Fatty Acids, Unsaturated	62-66	Delta(12) fatty acid desaturase fat-2	Caenorhabditis elegans	0-5
20226839-11	2010	Furthermore, treatment of the fat-2-RNAi worm with PUFA--using the fatty acids from linoleic acid through eicosapentaenoic acid--suppressed nuclear localization of DAF-16.	Fatty Acids, Unsaturated	51-55	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	164-170
20489212-5	2010	SCD1 knockdown-induced UPR was rescued by various unsaturated fatty acids and was enhanced by saturated fatty acid.	Fatty Acids, Unsaturated	50-73	stearoyl-CoA desaturase	Homo sapiens	0-4
20452984-2	2010	In plants, the endoplasmic reticulum (ER)-localized omega-3 fatty-acid desaturases (Fad3) increase the production of polyunsaturated fatty acids at cooler temperatures, but the FAD3 genes themselves are typically not up-regulated during this adaptive response.	Fatty Acids, Unsaturated	117-144	omega-3 fatty acid desaturase, endoplasmic reticulum	Nicotiana tabacum	84-88
20452984-2	2010	In plants, the endoplasmic reticulum (ER)-localized omega-3 fatty-acid desaturases (Fad3) increase the production of polyunsaturated fatty acids at cooler temperatures, but the FAD3 genes themselves are typically not up-regulated during this adaptive response.	Fatty Acids, Unsaturated	117-144	omega-3 fatty acid desaturase, endoplasmic reticulum	Nicotiana tabacum	177-181
20615224-1	2010	It was investigated whether dietary polyunsaturated fatty acids (PUFA) could influence colonic injury, tissue DNA damage, cytokines and myeloperoxidase activity (MPO) and plasma corticosterone in DSS-induced colitis rats.	Fatty Acids, Unsaturated	65-69	myeloperoxidase	Rattus norvegicus	136-151
20489212-6	2010	Lysophosphatidylcholine acyltransferase 3 (LPCAT3), which incorporates preferentially polyunsaturated fatty acids into phosphatidylcholine, was up-regulated in SCD1 knockdown cells.	Fatty Acids, Unsaturated	86-113	lysophosphatidylcholine acyltransferase 3	Homo sapiens	0-41
20489212-6	2010	Lysophosphatidylcholine acyltransferase 3 (LPCAT3), which incorporates preferentially polyunsaturated fatty acids into phosphatidylcholine, was up-regulated in SCD1 knockdown cells.	Fatty Acids, Unsaturated	86-113	lysophosphatidylcholine acyltransferase 3	Homo sapiens	43-49
20489212-6	2010	Lysophosphatidylcholine acyltransferase 3 (LPCAT3), which incorporates preferentially polyunsaturated fatty acids into phosphatidylcholine, was up-regulated in SCD1 knockdown cells.	Fatty Acids, Unsaturated	86-113	stearoyl-CoA desaturase	Homo sapiens	160-164
20045144-0	2010	Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism.	Fatty Acids, Unsaturated	41-67	fatty acid desaturase 1	Homo sapiens	8-13
19623607-6	2010	Altogether, the present data suggest that polyunsaturated fatty acids, such as docosahexaenoic acid, may act via FABP5 or 7 to regulate adult postischemic hippocampal neuronal antiapoptosis or neurogenesis in primates.	Fatty Acids, Unsaturated	42-69	fatty acid binding protein 5	Homo sapiens	113-118
20581078-1	2010	15-Lipoxygenase-1 catalyzes the introduction of molecular oxygen into polyunsaturated fatty acids to form a lipid hydroperoxide.	Fatty Acids, Unsaturated	70-97	arachidonate 15-lipoxygenase	Homo sapiens	0-15
20484448-1	2010	BACKGROUND: The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis.	Fatty Acids, Unsaturated	116-142	fatty acid desaturase 1	Homo sapiens	64-69
20484448-1	2010	BACKGROUND: The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis.	Fatty Acids, Unsaturated	116-142	fatty acid desaturase 2	Homo sapiens	74-79
20484448-1	2010	BACKGROUND: The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis.	Fatty Acids, Unsaturated	144-148	fatty acid desaturase 1	Homo sapiens	64-69
20484448-1	2010	BACKGROUND: The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis.	Fatty Acids, Unsaturated	144-148	fatty acid desaturase 2	Homo sapiens	74-79
20668324-7	2010	CONCLUSION: A longer and/or larger intervention or docosahexaenoic acid supplementation might be necessary to identify significant preventive effects of mega-3 polyunsaturated fatty acids on PSA recurrence.	Fatty Acids, Unsaturated	160-187	kallikrein related peptidase 3	Homo sapiens	191-194
20045144-0	2010	Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism.	Fatty Acids, Unsaturated	41-67	fatty acid desaturase 2	Homo sapiens	18-23
20004083-1	2010	OBJECTIVE: Expression characteristics of C-reactive protein (CRP) for the omega-6/omega-3 polyunsaturated fatty acid (PUFA) ratios have not been evaluated in the well-qualified experimental atherosclerotic mouse model.	Fatty Acids, Unsaturated	118-122	C-reactive protein, pentraxin-related	Mus musculus	41-59
20694299-1	2010	INTRODUCTION: The peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) is an adipogenic transcription factor that influences in insulin resistance (IR) in the presence of agonists such as polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	199-226	peroxisome proliferator activated receptor gamma	Homo sapiens	18-68
20694299-1	2010	INTRODUCTION: The peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) is an adipogenic transcription factor that influences in insulin resistance (IR) in the presence of agonists such as polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	199-226	peroxisome proliferator activated receptor gamma	Homo sapiens	70-80
20694299-1	2010	INTRODUCTION: The peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) is an adipogenic transcription factor that influences in insulin resistance (IR) in the presence of agonists such as polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	199-226	insulin	Homo sapiens	139-146
20694299-1	2010	INTRODUCTION: The peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) is an adipogenic transcription factor that influences in insulin resistance (IR) in the presence of agonists such as polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	228-232	peroxisome proliferator activated receptor gamma	Homo sapiens	18-68
20478617-0	2010	A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide.	Fatty Acids, Unsaturated	40-62	toll-like receptor 2	Mus musculus	95-99
20004083-1	2010	OBJECTIVE: Expression characteristics of C-reactive protein (CRP) for the omega-6/omega-3 polyunsaturated fatty acid (PUFA) ratios have not been evaluated in the well-qualified experimental atherosclerotic mouse model.	Fatty Acids, Unsaturated	118-122	C-reactive protein, pentraxin-related	Mus musculus	61-64
20694299-1	2010	INTRODUCTION: The peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) is an adipogenic transcription factor that influences in insulin resistance (IR) in the presence of agonists such as polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	228-232	peroxisome proliferator activated receptor gamma	Homo sapiens	70-80
20694299-1	2010	INTRODUCTION: The peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) is an adipogenic transcription factor that influences in insulin resistance (IR) in the presence of agonists such as polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	228-232	insulin	Homo sapiens	139-146
20385130-3	2010	The rate-limiting enzyme in unsaturated fatty acid biosynthesis is the desaturase enzyme which in turn is regulated by the lipid transcription factor sterol regulatory element binding protein (SREBP1).	Fatty Acids, Unsaturated	28-50	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	150-191
20349267-1	2010	Microsomal oleic acid desaturase (FAD2) catalyzes the first committed step of the biosynthesis of polyunsaturated fatty acids via extra-plastidial desaturation of oleic acid to linoleic acid.	Fatty Acids, Unsaturated	98-125	omega-6 fatty acid desaturase, endoplasmic reticulum isozyme 2	Sesamum indicum	34-38
20385130-3	2010	The rate-limiting enzyme in unsaturated fatty acid biosynthesis is the desaturase enzyme which in turn is regulated by the lipid transcription factor sterol regulatory element binding protein (SREBP1).	Fatty Acids, Unsaturated	28-50	sterol regulatory element binding transcription factor 1	Homo sapiens	193-199
20592462-2	2010	Our previous studies, however, indicated an implication of both bone marrow cells as potential progenitors of hippocampal newborn neurons and polyunsaturated fatty acids as ligands of G protein-coupled receptor 40 (GPR40) signaling.	Fatty Acids, Unsaturated	142-169	free fatty acid receptor 1	Homo sapiens	184-213
20357242-2	2010	Herein, we establish a critical role for 12/15-lipoxygenase (12/15-LOX)-mediated unsaturated fatty acid metabolism in HSC function.	Fatty Acids, Unsaturated	81-103	arachidonate 15-lipoxygenase	Mus musculus	41-59
20357242-2	2010	Herein, we establish a critical role for 12/15-lipoxygenase (12/15-LOX)-mediated unsaturated fatty acid metabolism in HSC function.	Fatty Acids, Unsaturated	81-103	arachidonate 15-lipoxygenase	Mus musculus	61-70
20592462-2	2010	Our previous studies, however, indicated an implication of both bone marrow cells as potential progenitors of hippocampal newborn neurons and polyunsaturated fatty acids as ligands of G protein-coupled receptor 40 (GPR40) signaling.	Fatty Acids, Unsaturated	142-169	free fatty acid receptor 1	Homo sapiens	215-220
19965574-4	2010	Interestingly, unsaturated fatty acids mimic the effects of synthetic PPARdelta agonists.	Fatty Acids, Unsaturated	15-38	peroxisome proliferator-activated receptor delta	Rattus norvegicus	70-79
20364269-9	2010	Furthermore, the variable effects of FADS1/FADS2 on plasma lipid profiles in Asians may result from differences in the dietary intake of polyunsaturated fatty acids, which serve as substrates for enzymes encoded by FADS1/FADS2.	Fatty Acids, Unsaturated	137-164	fatty acid desaturase 1	Homo sapiens	37-42
20364269-9	2010	Furthermore, the variable effects of FADS1/FADS2 on plasma lipid profiles in Asians may result from differences in the dietary intake of polyunsaturated fatty acids, which serve as substrates for enzymes encoded by FADS1/FADS2.	Fatty Acids, Unsaturated	137-164	fatty acid desaturase 2	Homo sapiens	43-48
20364269-9	2010	Furthermore, the variable effects of FADS1/FADS2 on plasma lipid profiles in Asians may result from differences in the dietary intake of polyunsaturated fatty acids, which serve as substrates for enzymes encoded by FADS1/FADS2.	Fatty Acids, Unsaturated	137-164	fatty acid desaturase 1	Homo sapiens	215-220
20364269-9	2010	Furthermore, the variable effects of FADS1/FADS2 on plasma lipid profiles in Asians may result from differences in the dietary intake of polyunsaturated fatty acids, which serve as substrates for enzymes encoded by FADS1/FADS2.	Fatty Acids, Unsaturated	137-164	fatty acid desaturase 2	Homo sapiens	221-226
20494167-4	2010	In particular, milk from cows receiving flaxseed supplementation showed a decrease in saturated fatty acid, an increase in monounsaturated fatty acid, and, together with the milk from fish oil-supplemented cows, an increase in polyunsaturated fatty acid content compared with milk from control cows.	Fatty Acids, Unsaturated	227-253	Weaning weight-maternal milk	Bos taurus	15-19
20071694-7	2010	Unexpectedly, the n-3 PUFA diet increased B-cell CD69 surface expression, IL-6 and IFNgamma secretion, and it significantly increased body weight gain.	Fatty Acids, Unsaturated	22-26	CD69 antigen	Mus musculus	49-53
20071694-7	2010	Unexpectedly, the n-3 PUFA diet increased B-cell CD69 surface expression, IL-6 and IFNgamma secretion, and it significantly increased body weight gain.	Fatty Acids, Unsaturated	22-26	interleukin 6	Mus musculus	74-78
20071694-7	2010	Unexpectedly, the n-3 PUFA diet increased B-cell CD69 surface expression, IL-6 and IFNgamma secretion, and it significantly increased body weight gain.	Fatty Acids, Unsaturated	22-26	interferon gamma	Mus musculus	83-91
20185359-6	2010	However, it is equally clear that a holistic understanding of plant lipid metabolism is still lacking, mainly owing to the continually emerging complexity and interplay between pathways, recently exemplified by the identification of the ROD1 phosphatidylcholine:diacylglycerol cholinephosphotransferase involved in the channelling of unsaturated fatty acids into storage oil.	Fatty Acids, Unsaturated	334-357	polypyrimidine tract binding protein 3	Homo sapiens	237-241
20190170-3	2010	Polyunsaturated fatty acids are potential ligands for PPARdelta activation.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activator receptor delta	Mus musculus	54-63
19965574-5	2010	Using short hairpin RNA-mediated knockdown, we demonstrate that the ability of unsaturated fatty acids to stimulate fatty acid metabolism is dependent on PPARdelta.	Fatty Acids, Unsaturated	79-102	peroxisome proliferator-activated receptor delta	Rattus norvegicus	154-163
19965574-7	2010	The presented results indicate that the nuclear receptor PPARdelta is a fatty acid sensor that adapts beta-cell mitochondrial function to long-term changes in unsaturated fatty acid levels.	Fatty Acids, Unsaturated	159-181	peroxisome proliferator-activated receptor delta	Rattus norvegicus	57-66
19443194-9	2010	NPC1L1 mRNA levels were reduced 35-58% by the n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (P&lt;.05).	Fatty Acids, Unsaturated	50-55	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	0-6
19443194-0	2010	Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids.	Fatty Acids, Unsaturated	0-27	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	115-121
19693691-1	2010	The mammalian fatty acid desaturase 2 (FADS2) gene codes for catalytic activity considered to be the rate limited step in long chain polyunsaturated fatty acid (LCPUFA) synthesis.	Fatty Acids, Unsaturated	133-159	fatty acid desaturase 2	Homo sapiens	14-37
19443194-4	2010	We evaluate the effect of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) on the expression of NPC1L1 and others proteins associated with cholesterol absorption (SR-BI, ABCG5, ABCG8, ABCA1, CAV-1, ANX-2) in human enterocytes in vitro.	Fatty Acids, Unsaturated	96-123	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	153-159
19693691-1	2010	The mammalian fatty acid desaturase 2 (FADS2) gene codes for catalytic activity considered to be the rate limited step in long chain polyunsaturated fatty acid (LCPUFA) synthesis.	Fatty Acids, Unsaturated	133-159	fatty acid desaturase 2	Homo sapiens	39-44
20424004-1	2010	We demonstrate that the transformation of soybean (Glycine max) with sense suppression constructs using intron sequences from the fatty acid oleyl Delta12 desaturase gene FAD2-1A leads to efficient and specific reduction of FAD2-1 transcripts in developing seeds, increased oleic acid, and decreased polyunsaturated fatty acids.	Fatty Acids, Unsaturated	300-327	omega-6 fatty acid desaturase	Glycine max	171-175
20424004-1	2010	We demonstrate that the transformation of soybean (Glycine max) with sense suppression constructs using intron sequences from the fatty acid oleyl Delta12 desaturase gene FAD2-1A leads to efficient and specific reduction of FAD2-1 transcripts in developing seeds, increased oleic acid, and decreased polyunsaturated fatty acids.	Fatty Acids, Unsaturated	300-327	omega-6 fatty acid desaturase, endoplasmic reticulum isozyme 1	Glycine max	171-177
20410050-5	2010	The fad6 tgd1-1 and fad6 tgd4-3 double mutants showed drastic reductions in the relative levels of polyunsaturated fatty acids and of galactolipids.	Fatty Acids, Unsaturated	99-126	fatty acid desaturase 6	Arabidopsis thaliana	4-8
20410050-5	2010	The fad6 tgd1-1 and fad6 tgd4-3 double mutants showed drastic reductions in the relative levels of polyunsaturated fatty acids and of galactolipids.	Fatty Acids, Unsaturated	99-126	fatty acid desaturase 6	Arabidopsis thaliana	20-24
20380772-9	2010	These associations are concordant with the preference of LIPE to selectively mobilize medium-chain and unsaturated fatty acids.	Fatty Acids, Unsaturated	103-126	hormone-sensitive lipase	Capra hircus	57-61
20487553-6	2010	These PUFAs, in particular the highly unsaturated n-3 fatty acids change the gene expression of PPARa and SREBP, suppress the expression of mRNAs encoding key metabolic enzymes and hereby suppress hepatic lipogenesis and triglyceride synthesis, as well as secretion and accumulation in tissues.	Fatty Acids, Unsaturated	6-11	peroxisome proliferator activated receptor alpha	Homo sapiens	96-101
20211608-1	2010	G-protein coupled receptor 40 (GPR40), which is expressed ubiquitously in the human brain and pancreas, is a member of the large family of seven-transmembrane receptors and can be activated by polyunsaturated fatty acid (PUFA), in particular docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	193-219	free fatty acid receptor 1	Homo sapiens	0-29
20211608-1	2010	G-protein coupled receptor 40 (GPR40), which is expressed ubiquitously in the human brain and pancreas, is a member of the large family of seven-transmembrane receptors and can be activated by polyunsaturated fatty acid (PUFA), in particular docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	193-219	free fatty acid receptor 1	Homo sapiens	31-36
20211608-1	2010	G-protein coupled receptor 40 (GPR40), which is expressed ubiquitously in the human brain and pancreas, is a member of the large family of seven-transmembrane receptors and can be activated by polyunsaturated fatty acid (PUFA), in particular docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	221-225	free fatty acid receptor 1	Homo sapiens	0-29
20211608-1	2010	G-protein coupled receptor 40 (GPR40), which is expressed ubiquitously in the human brain and pancreas, is a member of the large family of seven-transmembrane receptors and can be activated by polyunsaturated fatty acid (PUFA), in particular docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	221-225	free fatty acid receptor 1	Homo sapiens	31-36
22444129-3	2010	The diet enriched with n-3 polyunsaturated fatty acids (PUFAs) significantly inhibited SCD protein expression in muscle and subcutaneous adipose tissue, and reduced the Delta6d expression in muscle.	Fatty Acids, Unsaturated	56-61	stearoyl-CoA desaturase	Bos taurus	87-90
22444129-3	2010	The diet enriched with n-3 polyunsaturated fatty acids (PUFAs) significantly inhibited SCD protein expression in muscle and subcutaneous adipose tissue, and reduced the Delta6d expression in muscle.	Fatty Acids, Unsaturated	56-61	fatty acid desaturase 2	Bos taurus	169-176
20374857-4	2010	The percentage of saturated fatty acids was also similar, but the percentage of monounsaturated was significantly higher in the group with higher IMF and the percentage of polyunsaturated fatty acids was higher in the group with lower IMF.	Fatty Acids, Unsaturated	172-199	MyoD family inhibitor	Homo sapiens	235-238
20034614-0	2010	Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels.	Fatty Acids, Unsaturated	116-143	phospholipase A2 group IB	Homo sapiens	0-16
19998382-1	2010	Increased tissue n-3 polyunsaturated fatty acid (PUFA) is associated with improved insulin sensitivity in type 2 diabetes.	Fatty Acids, Unsaturated	49-53	insulin	Homo sapiens	83-90
20177777-1	2010	Fat-1 transgenic mice endogenously convert n-6 to n-3 polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	83-87	FAT atypical cadherin 1	Mus musculus	0-5
20097754-5	2010	In contrast, nitro derivatives of unsaturated fatty acids (NO(2)-FA) are endogenous products of nitric oxide ((*)NO) and nitrite (NO(2)(-))-mediated redox reactions that activate PPARgamma at nanomolar concentrations.	Fatty Acids, Unsaturated	34-57	peroxisome proliferator activated receptor gamma	Mus musculus	179-188
20354549-1	2010	Liver fatty acid-binding protein (L-FABP) binds selectively to intracellular free unsaturated fatty acids and lipid peroxidation products during hypoxic tissue injury.	Fatty Acids, Unsaturated	82-105	fatty acid binding protein 1	Homo sapiens	0-32
20354549-1	2010	Liver fatty acid-binding protein (L-FABP) binds selectively to intracellular free unsaturated fatty acids and lipid peroxidation products during hypoxic tissue injury.	Fatty Acids, Unsaturated	82-105	fatty acid binding protein 1	Homo sapiens	34-40
20207119-1	2010	Polyunsaturated fatty acids of nutritional value may affect cell functions after their release from cell lipid storage sites, especially phospholipids, and specific oxygenation by cyclooxygenases, lipoxygenases and cytochrome P(450).	Fatty Acids, Unsaturated	0-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	215-232
20156199-9	2010	Consistent with this, although NTL6 processing was stimulated by pharmacological agents that reduce membrane fluidity and thus mimic cold, it was inhibited when plants were treated with a 18:3 unsaturated fatty acid, linolenic acid.	Fatty Acids, Unsaturated	193-215	NAC domain containing protein 62	Arabidopsis thaliana	31-35
20145241-0	2010	Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Homo sapiens	49-92
20145241-2	2010	Polyunsaturated fatty acids (PUFA) selectively suppress hepatic SREBP-1, but molecular mechanisms remain largely unknown.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Homo sapiens	64-71
20145241-2	2010	Polyunsaturated fatty acids (PUFA) selectively suppress hepatic SREBP-1, but molecular mechanisms remain largely unknown.	Fatty Acids, Unsaturated	29-33	sterol regulatory element binding transcription factor 1	Homo sapiens	64-71
20182891-4	2010	Unexpectedly, the cellular level of beta-casein, accumulated under lactogenic hormone treatment, decreases following treatment of the cells with unsaturated fatty acids.	Fatty Acids, Unsaturated	145-168	casein beta	Mus musculus	36-47
20182891-6	2010	We demonstrate that the action of unsaturated fatty acids on the level of beta-casein is post-translational and requires protein synthesis.	Fatty Acids, Unsaturated	34-57	casein beta	Mus musculus	74-85
20182891-8	2010	Finally, lysosome inhibitors block the effect of unsaturated fatty acids on the cellular level of beta-casein.	Fatty Acids, Unsaturated	49-72	casein beta	Mus musculus	98-109
20096089-0	2010	Membrane lipid modification by polyunsaturated fatty acids sensitizes oligodendroglial OLN-93 cells against oxidative stress and promotes up-regulation of heme oxygenase-1 (HSP32).	Fatty Acids, Unsaturated	31-58	heme oxygenase 1	Rattus norvegicus	155-171
20096089-0	2010	Membrane lipid modification by polyunsaturated fatty acids sensitizes oligodendroglial OLN-93 cells against oxidative stress and promotes up-regulation of heme oxygenase-1 (HSP32).	Fatty Acids, Unsaturated	31-58	heme oxygenase 1	Rattus norvegicus	173-178
20034614-0	2010	Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels.	Fatty Acids, Unsaturated	116-143	prostaglandin-endoperoxide synthase 2	Homo sapiens	21-37
20034614-1	2010	BACKGROUND: Phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2) are the two key enzymes in the metabolism of polyunsaturated fatty acids, which in turn play an important role in cytokine-induced depression and sickness behavior.	Fatty Acids, Unsaturated	109-136	phospholipase A2 group IB	Homo sapiens	12-28
20034614-1	2010	BACKGROUND: Phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2) are the two key enzymes in the metabolism of polyunsaturated fatty acids, which in turn play an important role in cytokine-induced depression and sickness behavior.	Fatty Acids, Unsaturated	109-136	phospholipase A2 group IB	Homo sapiens	30-34
20034614-1	2010	BACKGROUND: Phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2) are the two key enzymes in the metabolism of polyunsaturated fatty acids, which in turn play an important role in cytokine-induced depression and sickness behavior.	Fatty Acids, Unsaturated	109-136	prostaglandin-endoperoxide synthase 2	Homo sapiens	40-56
20034614-1	2010	BACKGROUND: Phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2) are the two key enzymes in the metabolism of polyunsaturated fatty acids, which in turn play an important role in cytokine-induced depression and sickness behavior.	Fatty Acids, Unsaturated	109-136	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-62
19782984-4	2010	Palmitic acid showed the greatest enhancement of expression of lectin-like oxidized LDL receptor (LOX-1) among 7 NEFA examined (4 saturated and 3 unsaturated fatty acids).	Fatty Acids, Unsaturated	146-169	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	98-103
20388132-4	2010	We review results demonstrating how the balance between different classes of carbohydrates and proteins modulates the obesigenic action of saturated as well as unsaturated fatty acids pointing to insulin as a key determinant in the regulation of the metabolic/regulatory action of both n-3 and n-6 polyunsaturated fatty acids.	Fatty Acids, Unsaturated	160-183	insulin	Homo sapiens	196-203
19554614-5	2010	These FABP proteins are molecular chaperons for polyunsaturated fatty acids (PUFAs) such as arachidonic and docosahexaenoic acids.	Fatty Acids, Unsaturated	48-75	glutamic-oxaloacetic transaminase 2	Homo sapiens	6-10
19554614-5	2010	These FABP proteins are molecular chaperons for polyunsaturated fatty acids (PUFAs) such as arachidonic and docosahexaenoic acids.	Fatty Acids, Unsaturated	77-82	glutamic-oxaloacetic transaminase 2	Homo sapiens	6-10
20172237-11	2010	Fatty acid content further increased to 952 mg/g when a unique unsaturated fatty acid (C13:1) was used as the internal standard.	Fatty Acids, Unsaturated	63-85	homeobox C13	Homo sapiens	87-90
19969553-4	2010	Here, we show that dietary omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) can regulate the expression of EZH2 in breast cancer cells.	Fatty Acids, Unsaturated	74-79	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	112-116
19936816-9	2010	Normal egg-laying activity and acs-2 expression were restored on exposure to a polyunsaturated fatty acid.	Fatty Acids, Unsaturated	79-105	fatty Acid CoA Synthetase family	Caenorhabditis elegans	31-36
20383947-5	2010	Taken together, these results suggest the opposite effects of saturated fatty acids and polyunsaturated fatty acids on the expression of IDE, indicating a novel mechanism underlying the pharmacological function of fatty acids in AD intervention.	Fatty Acids, Unsaturated	88-115	insulin degrading enzyme	Homo sapiens	137-140
19752397-7	2010	This cluster includes the FADS1 and FADS2 genes encoding, respectively, for the Delta 5- and Delta 6-desaturases involved in polyunsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	125-151	fatty acid desaturase 1	Homo sapiens	26-31
19752397-7	2010	This cluster includes the FADS1 and FADS2 genes encoding, respectively, for the Delta 5- and Delta 6-desaturases involved in polyunsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	125-151	fatty acid desaturase 2	Homo sapiens	36-41
19752397-7	2010	This cluster includes the FADS1 and FADS2 genes encoding, respectively, for the Delta 5- and Delta 6-desaturases involved in polyunsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	125-151	fatty acid desaturase 1	Homo sapiens	80-112
20238044-4	2010	PUFAs are membrane targets of lipid peroxidation and natural ligands for the nuclear receptors, peroxisome proliferator activated receptors (PPAR).	Fatty Acids, Unsaturated	0-5	peroxisome proliferator activated receptor alpha	Homo sapiens	96-139
19908022-2	2010	Generally, lipotoxicity is triggered by saturated fatty acids, whereas unsaturated fatty acids induce lipodysfunction, the latter being characterised by elevated basal insulin release and impaired glucose responses.	Fatty Acids, Unsaturated	71-94	insulin	Homo sapiens	168-175
19842026-1	2010	Gamma linolenic acid (GLA) is a member of the n-6 family of polyunsaturated fatty acids and can be synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase.	Fatty Acids, Unsaturated	60-87	fatty acid desaturase 2	Mus musculus	149-167
20106645-4	2010	Our study tested whether the very low density lipoprotein receptor (VLDLr) is necessary for maintaining brain PUFA and cholesterol concentrations.	Fatty Acids, Unsaturated	110-114	very low density lipoprotein receptor	Mus musculus	29-66
20106645-4	2010	Our study tested whether the very low density lipoprotein receptor (VLDLr) is necessary for maintaining brain PUFA and cholesterol concentrations.	Fatty Acids, Unsaturated	110-114	very low density lipoprotein receptor	Mus musculus	68-73
20006581-3	2010	The ratio of unsaturated fatty acids and saturated fatty acids (UFAs/SFAs) was significantly lower in CS than in CTL.	Fatty Acids, Unsaturated	13-36	ctl	Drosophila melanogaster	113-116
19917068-7	2010	RESULTS: n-3 PUFA treatment resulted in a significant improvement (i.e. decrease) in the postprandial response for triglyceride (45%) (p &lt; 0.05), apoB48 (45%) (p &lt; 0.03) and LBP (33%) (p &lt; 0.05) compared to controls (measured as area under the clearance curve).	Fatty Acids, Unsaturated	13-17	apolipoprotein B	Rattus norvegicus	149-155
19917068-7	2010	RESULTS: n-3 PUFA treatment resulted in a significant improvement (i.e. decrease) in the postprandial response for triglyceride (45%) (p &lt; 0.05), apoB48 (45%) (p &lt; 0.03) and LBP (33%) (p &lt; 0.05) compared to controls (measured as area under the clearance curve).	Fatty Acids, Unsaturated	13-17	lipopolysaccharide binding protein	Rattus norvegicus	180-183
20032477-0	2010	Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults.	Fatty Acids, Unsaturated	44-71	leptin receptor	Homo sapiens	0-15
20032477-0	2010	Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults.	Fatty Acids, Unsaturated	44-71	insulin	Homo sapiens	91-98
20061930-0	2010	Omega-3 polyunsaturated fatty acids affect sirolimus exposure in kidney transplant recipients on calcineurin inhibitor-free regimen.	Fatty Acids, Unsaturated	8-35	calcineurin binding protein 1	Homo sapiens	97-118
20238044-4	2010	PUFAs are membrane targets of lipid peroxidation and natural ligands for the nuclear receptors, peroxisome proliferator activated receptors (PPAR).	Fatty Acids, Unsaturated	0-5	peroxisome proliferator activated receptor alpha	Homo sapiens	141-145
20013191-4	2010	We successfully generated the PI peroxides with soybean type-I lipoxygenase (LOX) in the presence of deoxycholate, which facilitates the LOX-mediated peroxidation of the polyunsaturated fatty acids esterified to the PL.	Fatty Acids, Unsaturated	170-197	seed linoleate 9S-lipoxygenase-3	Glycine max	77-80
19761868-9	2010	Furthermore, unsaturated fatty acids were better inhibitors of CES1 activity than saturated fatty acids, while CES2 activity was unaffected by any fatty acid.	Fatty Acids, Unsaturated	13-36	carboxylesterase 1	Homo sapiens	63-67
19733998-8	2010	The abundance of caveolin-1, ABCA1, and SREBP-2 were altered by PUFA-enriched diets (P&lt;0.05), whereas that of NPC1L1 and SR-B1 mRNA remained unchanged.	Fatty Acids, Unsaturated	64-68	caveolin 1	Canis lupus familiaris	17-27
19733998-8	2010	The abundance of caveolin-1, ABCA1, and SREBP-2 were altered by PUFA-enriched diets (P&lt;0.05), whereas that of NPC1L1 and SR-B1 mRNA remained unchanged.	Fatty Acids, Unsaturated	64-68	ATP binding cassette subfamily A member 1	Canis lupus familiaris	29-34
19733998-8	2010	The abundance of caveolin-1, ABCA1, and SREBP-2 were altered by PUFA-enriched diets (P&lt;0.05), whereas that of NPC1L1 and SR-B1 mRNA remained unchanged.	Fatty Acids, Unsaturated	64-68	sterol regulatory element binding transcription factor 2	Canis lupus familiaris	40-47
19733998-9	2010	The gene expression of caveolin-1, ABCA1, and SREBP-2 was down-regulated (P&lt;0.05) by PUFA-enriched diets in IBD dogs only.	Fatty Acids, Unsaturated	88-92	caveolin 1	Canis lupus familiaris	23-33
19733998-9	2010	The gene expression of caveolin-1, ABCA1, and SREBP-2 was down-regulated (P&lt;0.05) by PUFA-enriched diets in IBD dogs only.	Fatty Acids, Unsaturated	88-92	ATP binding cassette subfamily A member 1	Canis lupus familiaris	35-40
19733998-9	2010	The gene expression of caveolin-1, ABCA1, and SREBP-2 was down-regulated (P&lt;0.05) by PUFA-enriched diets in IBD dogs only.	Fatty Acids, Unsaturated	88-92	sterol regulatory element binding transcription factor 2	Canis lupus familiaris	46-53
20513971-0	2010	Synthesis of phospholipids containing polyunsaturated fatty acids by phospholipase A(2)-mediated esterification with food-compatible reagents.	Fatty Acids, Unsaturated	38-65	phospholipase A2 group IB	Homo sapiens	69-87
20513971-3	2010	Phospholipase A(2) (PLA(2))-mediated ester synthesis was employed to introduce the PUFAs into the sn-2 position of lysophospholipid (LPL) to yield PUFA-containing PLs.	Fatty Acids, Unsaturated	83-88	phospholipase A2 group IB	Homo sapiens	0-18
20513971-3	2010	Phospholipase A(2) (PLA(2))-mediated ester synthesis was employed to introduce the PUFAs into the sn-2 position of lysophospholipid (LPL) to yield PUFA-containing PLs.	Fatty Acids, Unsaturated	83-88	phospholipase A2 group IB	Homo sapiens	20-26
20013191-4	2010	We successfully generated the PI peroxides with soybean type-I lipoxygenase (LOX) in the presence of deoxycholate, which facilitates the LOX-mediated peroxidation of the polyunsaturated fatty acids esterified to the PL.	Fatty Acids, Unsaturated	170-197	seed linoleate 9S-lipoxygenase-3	Glycine max	137-140
19850930-2	2009	Three new epsilon-specific PKC activators, made by cyclopropanation of polyunsaturated fatty acids, have been developed.	Fatty Acids, Unsaturated	71-98	protein kinase C epsilon	Homo sapiens	27-30
19896458-9	2009	On the other hand, polyunsaturated fatty acids (PUFAs) reduced osmotic-stress tolerance in fat-2-RNAi worms, whereas PUFAs enhanced it in nhr-49-RNAi worms.	Fatty Acids, Unsaturated	19-46	Delta(12) fatty acid desaturase fat-2	Caenorhabditis elegans	91-96
19896458-9	2009	On the other hand, polyunsaturated fatty acids (PUFAs) reduced osmotic-stress tolerance in fat-2-RNAi worms, whereas PUFAs enhanced it in nhr-49-RNAi worms.	Fatty Acids, Unsaturated	48-53	Delta(12) fatty acid desaturase fat-2	Caenorhabditis elegans	91-96
20027295-4	2009	Lipidomic analysis revealed that Fas2 KO cells were severely restricted in production of unsaturated fatty acids.	Fatty Acids, Unsaturated	89-112	trifunctional fatty acid synthase subunit FAS2	Saccharomyces cerevisiae S288C	33-37
20553076-5	2009	IGFBP-3 levels were associated with higher intakes of milk, yogurt, fruits and vitamin C, and lower intakes of rice, energy, protein, carbohydrate, sodium and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	159-186	insulin like growth factor binding protein 3	Homo sapiens	0-7
19828715-0	2009	Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome.	Fatty Acids, Unsaturated	51-78	complement C3	Homo sapiens	0-22
19625064-2	2009	Fasting concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP), key inflammatory mediators, decrease after sustained n-3 polyunsaturated fatty acid (PUFA) intake; however, the ability of n-3 PUFA to attenuate postprandial inflammatory responses is not well studied.	Fatty Acids, Unsaturated	162-166	interleukin 6	Homo sapiens	26-39
19915887-7	2009	The phosphatidylethanolamine saturated to polyunsaturated fatty acid ratio showed highly significant positive correlations with the EDSS and CRP &lt; 5 microg/ml.	Fatty Acids, Unsaturated	42-68	C-reactive protein	Homo sapiens	141-144
19716432-2	2009	Conversely, polyunsaturated fatty acids (PUFA) decrease lipogenic gene transcription via suppression of SREBP-1c.	Fatty Acids, Unsaturated	12-39	sterol regulatory element binding transcription factor 1	Rattus norvegicus	104-112
19716432-2	2009	Conversely, polyunsaturated fatty acids (PUFA) decrease lipogenic gene transcription via suppression of SREBP-1c.	Fatty Acids, Unsaturated	41-45	sterol regulatory element binding transcription factor 1	Rattus norvegicus	104-112
19860831-0	2009	Fatty aldehyde dehydrogenase is up-regulated by polyunsaturated fatty acid via peroxisome proliferator-activated receptor alpha and suppresses polyunsaturated fatty acid-induced endoplasmic reticulum stress.	Fatty Acids, Unsaturated	48-74	aldehyde dehydrogenase 3 family member A2	Homo sapiens	0-28
19860831-0	2009	Fatty aldehyde dehydrogenase is up-regulated by polyunsaturated fatty acid via peroxisome proliferator-activated receptor alpha and suppresses polyunsaturated fatty acid-induced endoplasmic reticulum stress.	Fatty Acids, Unsaturated	48-74	peroxisome proliferator activated receptor alpha	Homo sapiens	79-127
19860831-0	2009	Fatty aldehyde dehydrogenase is up-regulated by polyunsaturated fatty acid via peroxisome proliferator-activated receptor alpha and suppresses polyunsaturated fatty acid-induced endoplasmic reticulum stress.	Fatty Acids, Unsaturated	143-169	aldehyde dehydrogenase 3 family member A2	Homo sapiens	0-28
19860831-8	2009	These results suggest the autocatalytic nature of the FALDH-N system against endoplasmic reticulum stress that is induced by polyunsaturated fatty acid; polyunsaturated fatty acid binds to peroxisomal proliferator-activated receptor alpha to activate the expression of FALDH-N, which then detoxifies polyunsaturated fatty acid-derived fatty aldehydes and protects cells from endoplasmic reticulum stress.	Fatty Acids, Unsaturated	125-151	aldehyde dehydrogenase 3 family member A2	Homo sapiens	54-59
19860831-8	2009	These results suggest the autocatalytic nature of the FALDH-N system against endoplasmic reticulum stress that is induced by polyunsaturated fatty acid; polyunsaturated fatty acid binds to peroxisomal proliferator-activated receptor alpha to activate the expression of FALDH-N, which then detoxifies polyunsaturated fatty acid-derived fatty aldehydes and protects cells from endoplasmic reticulum stress.	Fatty Acids, Unsaturated	125-151	aldehyde dehydrogenase 3 family member A2	Homo sapiens	269-274
19860831-8	2009	These results suggest the autocatalytic nature of the FALDH-N system against endoplasmic reticulum stress that is induced by polyunsaturated fatty acid; polyunsaturated fatty acid binds to peroxisomal proliferator-activated receptor alpha to activate the expression of FALDH-N, which then detoxifies polyunsaturated fatty acid-derived fatty aldehydes and protects cells from endoplasmic reticulum stress.	Fatty Acids, Unsaturated	153-179	aldehyde dehydrogenase 3 family member A2	Homo sapiens	54-59
19860831-8	2009	These results suggest the autocatalytic nature of the FALDH-N system against endoplasmic reticulum stress that is induced by polyunsaturated fatty acid; polyunsaturated fatty acid binds to peroxisomal proliferator-activated receptor alpha to activate the expression of FALDH-N, which then detoxifies polyunsaturated fatty acid-derived fatty aldehydes and protects cells from endoplasmic reticulum stress.	Fatty Acids, Unsaturated	153-179	aldehyde dehydrogenase 3 family member A2	Homo sapiens	269-274
19625064-2	2009	Fasting concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP), key inflammatory mediators, decrease after sustained n-3 polyunsaturated fatty acid (PUFA) intake; however, the ability of n-3 PUFA to attenuate postprandial inflammatory responses is not well studied.	Fatty Acids, Unsaturated	162-166	interleukin 6	Homo sapiens	41-45
19625064-2	2009	Fasting concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP), key inflammatory mediators, decrease after sustained n-3 polyunsaturated fatty acid (PUFA) intake; however, the ability of n-3 PUFA to attenuate postprandial inflammatory responses is not well studied.	Fatty Acids, Unsaturated	162-166	C-reactive protein	Homo sapiens	71-74
19765573-10	2009	These results suggest that part of the mechanism of protection of the kidney by unsaturated fatty acids is through inhibition of ER stress, eIF2alpha phosphorylation and consequential reduction of CHOP protein expression and apoptotic renal cell death.	Fatty Acids, Unsaturated	80-103	eukaryotic translation initiation factor 2A	Rattus norvegicus	140-149
20011101-9	2009	We show that long-term adaptation requires polyunsaturated fatty acids (PUFAs) that may act on the transient receptor potential (TRP) channel type V OSM-9 downstream of EGL-4 nuclear entry.	Fatty Acids, Unsaturated	43-70	ANK_REP_REGION domain-containing protein	Caenorhabditis elegans	149-154
20011101-9	2009	We show that long-term adaptation requires polyunsaturated fatty acids (PUFAs) that may act on the transient receptor potential (TRP) channel type V OSM-9 downstream of EGL-4 nuclear entry.	Fatty Acids, Unsaturated	43-70	cGMP-dependent protein kinase;cGMP-dependent protein kinase egl-4	Caenorhabditis elegans	169-174
19875678-3	2009	The extent of membrane proton leak was drastically reduced in the fad2 mutant, containing low amounts of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	105-132	fatty acid desaturase 2	Arabidopsis thaliana	66-70
19875678-4	2009	Conversely, this proton leak was higher in FAD3(+) mitochondria that exhibit a higher polyunsaturated fatty acid content and high protein to lipid ratio.	Fatty Acids, Unsaturated	86-112	fatty acid desaturase 3	Arabidopsis thaliana	43-47
19765573-10	2009	These results suggest that part of the mechanism of protection of the kidney by unsaturated fatty acids is through inhibition of ER stress, eIF2alpha phosphorylation and consequential reduction of CHOP protein expression and apoptotic renal cell death.	Fatty Acids, Unsaturated	80-103	DNA-damage inducible transcript 3	Rattus norvegicus	197-201
19455584-2	2009	The lipid messenger was released upon ONOO(-)-dependent activation of cytosolic phospholipase A(2) and its pharmacological inhibition, or knock-down, was invariably associated with a prompt apoptotic response sensitive to exogenous ARA, but insensitive to other polyunsaturated fatty acids, as eicosapentaenoic or linoleic acid.	Fatty Acids, Unsaturated	262-289	phospholipase A2 group IVA	Rattus norvegicus	70-97
19747490-2	2009	Recently, the possible interaction between alpha-syn and polyunsaturated fatty acids has attracted a strong interest.	Fatty Acids, Unsaturated	57-84	synuclein alpha	Homo sapiens	43-52
19679157-1	2009	Dietary polyunsaturated fatty acids (PUFA) play a key role in regulating delta-6 desaturase (D6D), the key enzyme for long-chain PUFA biosynthesis.	Fatty Acids, Unsaturated	8-35	fatty acid desaturase 2	Rattus norvegicus	73-91
19632286-3	2009	The ten-month high n-3 PUFA treatment which preceded the MPTP exposure induced an increase of BDNF mRNA expression in the striatum, but not in the motor cortex of animals fed the high n-3 PUFA diet.	Fatty Acids, Unsaturated	23-27	brain derived neurotrophic factor	Mus musculus	94-98
19679157-1	2009	Dietary polyunsaturated fatty acids (PUFA) play a key role in regulating delta-6 desaturase (D6D), the key enzyme for long-chain PUFA biosynthesis.	Fatty Acids, Unsaturated	8-35	fatty acid desaturase 2	Rattus norvegicus	93-96
19679157-1	2009	Dietary polyunsaturated fatty acids (PUFA) play a key role in regulating delta-6 desaturase (D6D), the key enzyme for long-chain PUFA biosynthesis.	Fatty Acids, Unsaturated	37-41	fatty acid desaturase 2	Rattus norvegicus	73-91
19916943-0	2009	Preparation and characterization of Cu,Zn-superoxide dismutase covalently modified by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	86-113	superoxide dismutase 1	Homo sapiens	36-62
19679157-1	2009	Dietary polyunsaturated fatty acids (PUFA) play a key role in regulating delta-6 desaturase (D6D), the key enzyme for long-chain PUFA biosynthesis.	Fatty Acids, Unsaturated	37-41	fatty acid desaturase 2	Rattus norvegicus	93-96
19916943-4	2009	The results characterize SOD modified with polyunsaturated fatty acids as a promising pharmacological tool.	Fatty Acids, Unsaturated	43-70	superoxide dismutase 1	Homo sapiens	25-28
19679157-3	2009	It has been generally admitted that C18 unsaturated fatty acids (UFAs) regulate negatively delta-6 desaturase (D6D).	Fatty Acids, Unsaturated	65-69	fatty acid desaturase 2	Rattus norvegicus	91-109
19679157-3	2009	It has been generally admitted that C18 unsaturated fatty acids (UFAs) regulate negatively delta-6 desaturase (D6D).	Fatty Acids, Unsaturated	65-69	fatty acid desaturase 2	Rattus norvegicus	111-114
19679157-6	2009	Because the choice of the basal diet appeared to be of primary importance in such experiments, our goal was to reconsider the specific role of dietary UFAs on D6D regulation, depending on nutritional conditions.	Fatty Acids, Unsaturated	151-155	fatty acid desaturase 2	Rattus norvegicus	159-162
19679157-10	2009	In contrast, when pure UFAs were added to an HS base, D6D specific activities remained unchanged or increased.	Fatty Acids, Unsaturated	23-27	fatty acid desaturase 2	Rattus norvegicus	54-57
19679157-12	2009	Altogether, this study evidenced the importance of the nutritional status in D6D regulation by C18 UFAs: when used as control, HG/FF diet stimulates D6D compared with a standard control diet containing starch and 4% fats, leading to an overestimation of the D6D regulation by UFAs.	Fatty Acids, Unsaturated	99-103	fatty acid desaturase 2	Rattus norvegicus	77-80
19679157-12	2009	Altogether, this study evidenced the importance of the nutritional status in D6D regulation by C18 UFAs: when used as control, HG/FF diet stimulates D6D compared with a standard control diet containing starch and 4% fats, leading to an overestimation of the D6D regulation by UFAs.	Fatty Acids, Unsaturated	276-280	fatty acid desaturase 2	Rattus norvegicus	77-80
19679157-12	2009	Altogether, this study evidenced the importance of the nutritional status in D6D regulation by C18 UFAs: when used as control, HG/FF diet stimulates D6D compared with a standard control diet containing starch and 4% fats, leading to an overestimation of the D6D regulation by UFAs.	Fatty Acids, Unsaturated	276-280	fatty acid desaturase 2	Rattus norvegicus	149-152
19679157-12	2009	Altogether, this study evidenced the importance of the nutritional status in D6D regulation by C18 UFAs: when used as control, HG/FF diet stimulates D6D compared with a standard control diet containing starch and 4% fats, leading to an overestimation of the D6D regulation by UFAs.	Fatty Acids, Unsaturated	276-280	fatty acid desaturase 2	Rattus norvegicus	149-152
19814866-6	2009	The aim of this study was to investigate and compare the potential effects of peroxisome proliferator-activated receptor (PPAR)-alpha agonists fenofibrate and n-3 polyunsaturated fatty acids (PUFAs) in modulation of AMPK-alpha1 activity in liver and skeletal muscle of high-fat diet fed rats.	Fatty Acids, Unsaturated	192-197	peroxisome proliferator activated receptor alpha	Rattus norvegicus	78-133
19887546-3	2009	Here, we report that omega-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) inhibit HCC growth through simultaneously inhibition of COX-2 and beta-catenin.	Fatty Acids, Unsaturated	58-62	prostaglandin-endoperoxide synthase 2	Homo sapiens	181-186
19887546-3	2009	Here, we report that omega-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) inhibit HCC growth through simultaneously inhibition of COX-2 and beta-catenin.	Fatty Acids, Unsaturated	58-62	catenin beta 1	Homo sapiens	191-203
19646964-0	2009	A role for AMPK in the inhibition of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	74-101	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	11-15
19646964-0	2009	A role for AMPK in the inhibition of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	74-101	glucose-6-phosphate dehydrogenase	Rattus norvegicus	37-70
19646964-6	2009	These data suggest a role for AMPK in the inhibition of G6PD by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	64-91	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	30-34
19646964-6	2009	These data suggest a role for AMPK in the inhibition of G6PD by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	64-91	glucose-6-phosphate dehydrogenase	Rattus norvegicus	56-60
19671018-7	2009	Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells, which express CYP2E1 (E47 cells) but not control C34HepG2 cells, which do not express CYP2E1.	Fatty Acids, Unsaturated	9-36	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	91-97
19675224-2	2009	When ovalbumin was coupled to liposomes made by using unsaturated fatty acids, it was found to be presented not only to CD4(+) T cells but also to CD8(+) T cells and induced cytotoxic T lymphocytes (CTLs) which effectively eradicated the tumor from mice.	Fatty Acids, Unsaturated	54-77	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	5-14
19675224-2	2009	When ovalbumin was coupled to liposomes made by using unsaturated fatty acids, it was found to be presented not only to CD4(+) T cells but also to CD8(+) T cells and induced cytotoxic T lymphocytes (CTLs) which effectively eradicated the tumor from mice.	Fatty Acids, Unsaturated	54-77	CD4 antigen	Mus musculus	120-123
19725874-6	2009	CRLPs enriched in polyunsaturated fatty acids compared with saturated or monounsaturated fatty acids had a markedly greater inhibitory effect on NF-kappaB binding to DNA and the expression of phospho-p65-NF-kappaB and pIkappaB.	Fatty Acids, Unsaturated	18-45	nuclear factor kappa B subunit 1	Homo sapiens	145-154
19725874-6	2009	CRLPs enriched in polyunsaturated fatty acids compared with saturated or monounsaturated fatty acids had a markedly greater inhibitory effect on NF-kappaB binding to DNA and the expression of phospho-p65-NF-kappaB and pIkappaB.	Fatty Acids, Unsaturated	18-45	nuclear factor kappa B subunit 1	Homo sapiens	204-213
19814866-6	2009	The aim of this study was to investigate and compare the potential effects of peroxisome proliferator-activated receptor (PPAR)-alpha agonists fenofibrate and n-3 polyunsaturated fatty acids (PUFAs) in modulation of AMPK-alpha1 activity in liver and skeletal muscle of high-fat diet fed rats.	Fatty Acids, Unsaturated	192-197	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	216-227
19351970-1	2009	Delta-6 desaturase (D6D) catalyzes the first step in the synthesis of highly unsaturated fatty acids (HUFA) such as arachidonic (AA), docosapentaenoic (DPAn-6), and docosahexaenoic (DHA) acids, as well as the last desaturation of DPAn-6 and DHA.	Fatty Acids, Unsaturated	77-100	fatty acid desaturase 2	Mus musculus	0-18
19474526-7	2009	For the first time, positive relationships are reported between the proportion of n-6 polyunsaturated fatty acids (PUFA) in adipose tissue and adiponectin concentration and expression.	Fatty Acids, Unsaturated	115-119	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	143-154
19351970-1	2009	Delta-6 desaturase (D6D) catalyzes the first step in the synthesis of highly unsaturated fatty acids (HUFA) such as arachidonic (AA), docosapentaenoic (DPAn-6), and docosahexaenoic (DHA) acids, as well as the last desaturation of DPAn-6 and DHA.	Fatty Acids, Unsaturated	77-100	fatty acid desaturase 2	Mus musculus	20-23
19794119-7	2009	We conclude that the accumulation of free polyunsaturated fatty acids causes membrane damage in pxa1 and kat2 plants and propose a model in which fatty acid respiration via peroxisomal beta-oxidation plays a major role in dark-treated plants after depletion of starch reserves.	Fatty Acids, Unsaturated	42-69	peroxisomal ABC transporter 1	Arabidopsis thaliana	96-100
19184219-0	2009	Highly unsaturated fatty acid synthesis in Atlantic salmon: characterization of ELOVL5- and ELOVL2-like elongases.	Fatty Acids, Unsaturated	7-29	elongation of very long chain fatty acids protein 2	Salmo salar	92-98
19666541-4	2009	Interestingly, we found this TR4-mediated CD36 transactivation can be further enhanced by polyunsaturated fatty acids (PUFAs), such as omega-3 and -6 fatty acids, and their metabolites such as 15-hydroxyeico-satetraonic acid (15-HETE) and 13-hydroxy octa-deca dieonic acid (13-HODE) and thiazolidinedione (TZD)-rosiglitazone.	Fatty Acids, Unsaturated	90-117	nuclear receptor subfamily 2, group C, member 2	Mus musculus	29-32
19666541-4	2009	Interestingly, we found this TR4-mediated CD36 transactivation can be further enhanced by polyunsaturated fatty acids (PUFAs), such as omega-3 and -6 fatty acids, and their metabolites such as 15-hydroxyeico-satetraonic acid (15-HETE) and 13-hydroxy octa-deca dieonic acid (13-HODE) and thiazolidinedione (TZD)-rosiglitazone.	Fatty Acids, Unsaturated	119-124	nuclear receptor subfamily 2, group C, member 2	Mus musculus	29-32
19465148-7	2009	LCAD plays an essential role in the oxidation of unsaturated fatty acids such as oleic acid, but seems redundant in the oxidation of saturated fatty acids.	Fatty Acids, Unsaturated	49-72	acyl-CoA dehydrogenase long chain	Homo sapiens	0-4
22444850-1	2009	The present study investigated whether enrichment of the pig maternal diet with n-3 polyunsaturated fatty acids (PUFA) affects the fatty-acid composition of female piglets via enhancing of expression of the lipogenic enzymes Delta5-desaturase (Delta5d) and Delta6-desaturase (Delta6d).	Fatty Acids, Unsaturated	113-117	Polyunsaturated fatty acid percentage	Sus scrofa	84-111
19705039-3	2009	However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non-apolipoprotein E (APOE) epsilon4 carriers, and on cognitive symptoms only in very mild Alzheimer"s disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE epsilon4 carriers.	Fatty Acids, Unsaturated	55-59	apolipoprotein E	Homo sapiens	122-138
19705039-3	2009	However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non-apolipoprotein E (APOE) epsilon4 carriers, and on cognitive symptoms only in very mild Alzheimer"s disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE epsilon4 carriers.	Fatty Acids, Unsaturated	55-59	apolipoprotein E	Homo sapiens	140-144
19705039-3	2009	However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non-apolipoprotein E (APOE) epsilon4 carriers, and on cognitive symptoms only in very mild Alzheimer"s disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE epsilon4 carriers.	Fatty Acids, Unsaturated	55-59	apolipoprotein E	Homo sapiens	290-294
19465424-6	2009	RESULTS: The multivariate ORs were 0.65 [95% confidence interval (CI) 0.43-0.98] for the highest versus lowest tertile of vegetable fats and 0.66 (95% CI 0.44-0.97) for polyunsaturated fatty acids.	Fatty Acids, Unsaturated	169-196	chromosome 10 open reading frame 90	Homo sapiens	132-136
21291825-1	2009	BACKGROUND: Polyunsaturated fatty acids lower serum triglycerides by a mechanism that may involve the inhibition of stearoyl-CoA desaturase (SCD).	Fatty Acids, Unsaturated	12-39	stearoyl-CoA desaturase	Homo sapiens	116-139
21291825-1	2009	BACKGROUND: Polyunsaturated fatty acids lower serum triglycerides by a mechanism that may involve the inhibition of stearoyl-CoA desaturase (SCD).	Fatty Acids, Unsaturated	12-39	stearoyl-CoA desaturase	Homo sapiens	141-144
19474136-10	2009	Marine n-3 PUFAs were significantly positively associated with HDL cholesterol in Japanese (beta = 2.15, P &lt; 0.05), and eicosapentaenoic acid was significantly positively associated with HDL cholesterol in whites (beta = 2.68, P &lt; 0.01).	Fatty Acids, Unsaturated	11-16	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	92-100
19582494-3	2009	We have previously demonstrated activation of SREBP-2 by the polyunsaturated fatty acid docosahexaenoic acid (DHA) in SW620 colon cancer cells.	Fatty Acids, Unsaturated	61-87	sterol regulatory element binding transcription factor 2	Homo sapiens	46-53
19577914-1	2009	The long-chain polyunsaturated fatty acid (LC-PUFA) intake in preterm infants is crucial for normal central nervous system development and has the potential for long-lasting effects that extend beyond the period of dietary insufficiency.	Fatty Acids, Unsaturated	15-41	pumilio RNA binding family member 3	Homo sapiens	46-50
19497410-0	2009	Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells.	Fatty Acids, Unsaturated	53-75	lactalbumin alpha	Homo sapiens	24-41
19597489-5	2009	We found that yeast Pin1 (Ess1) is essential for viability because it controls the NF-kappaB-related Spt23 transcription factor involved in unsaturated fatty-acid synthesis.	Fatty Acids, Unsaturated	140-162	peptidylprolyl isomerase ESS1	Saccharomyces cerevisiae S288C	20-24
19597489-5	2009	We found that yeast Pin1 (Ess1) is essential for viability because it controls the NF-kappaB-related Spt23 transcription factor involved in unsaturated fatty-acid synthesis.	Fatty Acids, Unsaturated	140-162	peptidylprolyl isomerase ESS1	Saccharomyces cerevisiae S288C	26-30
19567784-0	2009	Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cells.	Fatty Acids, Unsaturated	8-35	C-X-C motif chemokine receptor 4	Homo sapiens	50-55
19528615-9	2009	Unsaturated fatty acids were greater in milk from cows fed FFCG than in milk from cows fed the control, WCS, or TAL.	Fatty Acids, Unsaturated	0-23	Weaning weight-maternal milk	Bos taurus	72-76
19528615-9	2009	Unsaturated fatty acids were greater in milk from cows fed FFCG than in milk from cows fed the control, WCS, or TAL.	Fatty Acids, Unsaturated	0-23	Weaning weight-maternal milk	Bos taurus	40-44
19578400-3	2009	To elucidate the role of 2,4-dienoyl-CoA reductase (DECR) as an auxiliary enzyme in the mitochondrial beta-oxidation of unsaturated fatty acids, we created a DECR-deficient mouse line.	Fatty Acids, Unsaturated	120-143	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	25-50
19578400-3	2009	To elucidate the role of 2,4-dienoyl-CoA reductase (DECR) as an auxiliary enzyme in the mitochondrial beta-oxidation of unsaturated fatty acids, we created a DECR-deficient mouse line.	Fatty Acids, Unsaturated	120-143	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	52-56
19578400-4	2009	In Decr(-/-) mice, the mitochondrial beta-oxidation of unsaturated fatty acids with double bonds is expected to halt at the level of trans-2, cis/trans-4-dienoyl-CoA intermediates.	Fatty Acids, Unsaturated	55-78	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	3-7
19578400-5	2009	In line with this expectation, fasted Decr(-/-) mice displayed increased serum acylcarnitines, especially decadienoylcarnitine, a product of the incomplete oxidation of linoleic acid (C(18:2)), urinary excretion of unsaturated dicarboxylic acids, and hepatic steatosis, wherein unsaturated fatty acids accumulate in liver triacylglycerols.	Fatty Acids, Unsaturated	278-301	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	38-42
19558671-5	2009	Based on these observations, we sought to investigate the impact of unsaturated fatty acids such as oleic acid in the presence of TNF-alpha in terms of insulin production, the molecular mechanisms involved and the in vivo effect of a diet high in oleic acid on a mouse model of type II diabetes, KKAy.	Fatty Acids, Unsaturated	68-91	tumor necrosis factor	Mus musculus	130-139
19070858-2	2009	Unsaturated fatty acids can inhibit cholesterol efflux from macrophages by increasing degradation of ABCA1.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	101-106
19536303-2	2009	Studies have suggested that patients with STGD3 have aberrant metabolism of docosahexaenoic acid (DHA, 22:6n3), the major polyunsaturated fatty acid (PUFA) in retinal rod outer segment membranes.	Fatty Acids, Unsaturated	122-148	ELOVL fatty acid elongase 4	Homo sapiens	42-47
19536303-2	2009	Studies have suggested that patients with STGD3 have aberrant metabolism of docosahexaenoic acid (DHA, 22:6n3), the major polyunsaturated fatty acid (PUFA) in retinal rod outer segment membranes.	Fatty Acids, Unsaturated	150-154	ELOVL fatty acid elongase 4	Homo sapiens	42-47
19070859-1	2009	We previously showed that polymorphisms in the tumor necrosis factor (TNF)-alpha gene, which is regulated by nuclear factor kappa B (NF-kappaB), modify the association between dietary polyunsaturated fatty acid (PUFA) intake and circulating HDL-cholesterol.	Fatty Acids, Unsaturated	212-216	nuclear factor kappa B subunit 1	Homo sapiens	133-142
19070858-3	2009	However, the detailed mechanisms of ABCA1 regulation by unsaturated fatty acids are not fully understood.	Fatty Acids, Unsaturated	56-79	ATP binding cassette subfamily A member 1	Homo sapiens	36-41
19070859-0	2009	NF-kappaB -94Ins/Del ATTG polymorphism modifies the association between dietary polyunsaturated fatty acids and HDL-cholesterol in two distinct populations.	Fatty Acids, Unsaturated	80-107	nuclear factor kappa B subunit 1	Homo sapiens	0-9
19070859-1	2009	We previously showed that polymorphisms in the tumor necrosis factor (TNF)-alpha gene, which is regulated by nuclear factor kappa B (NF-kappaB), modify the association between dietary polyunsaturated fatty acid (PUFA) intake and circulating HDL-cholesterol.	Fatty Acids, Unsaturated	184-210	tumor necrosis factor	Homo sapiens	47-80
19070859-1	2009	We previously showed that polymorphisms in the tumor necrosis factor (TNF)-alpha gene, which is regulated by nuclear factor kappa B (NF-kappaB), modify the association between dietary polyunsaturated fatty acid (PUFA) intake and circulating HDL-cholesterol.	Fatty Acids, Unsaturated	184-210	nuclear factor kappa B subunit 1	Homo sapiens	109-131
19070859-1	2009	We previously showed that polymorphisms in the tumor necrosis factor (TNF)-alpha gene, which is regulated by nuclear factor kappa B (NF-kappaB), modify the association between dietary polyunsaturated fatty acid (PUFA) intake and circulating HDL-cholesterol.	Fatty Acids, Unsaturated	184-210	nuclear factor kappa B subunit 1	Homo sapiens	133-142
19070859-1	2009	We previously showed that polymorphisms in the tumor necrosis factor (TNF)-alpha gene, which is regulated by nuclear factor kappa B (NF-kappaB), modify the association between dietary polyunsaturated fatty acid (PUFA) intake and circulating HDL-cholesterol.	Fatty Acids, Unsaturated	212-216	tumor necrosis factor	Homo sapiens	47-80
19070859-1	2009	We previously showed that polymorphisms in the tumor necrosis factor (TNF)-alpha gene, which is regulated by nuclear factor kappa B (NF-kappaB), modify the association between dietary polyunsaturated fatty acid (PUFA) intake and circulating HDL-cholesterol.	Fatty Acids, Unsaturated	212-216	nuclear factor kappa B subunit 1	Homo sapiens	109-131
19202133-1	2009	The mammalian Delta6-desaturase coded by fatty acid desaturase 2 (FADS2; HSA11q12-q13.1) catalyzes the first and rate-limiting step for the biosynthesis of long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	167-194	fatty acid desaturase 2	Homo sapiens	20-31
19202133-1	2009	The mammalian Delta6-desaturase coded by fatty acid desaturase 2 (FADS2; HSA11q12-q13.1) catalyzes the first and rate-limiting step for the biosynthesis of long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	167-194	fatty acid desaturase 2	Homo sapiens	41-64
19202133-1	2009	The mammalian Delta6-desaturase coded by fatty acid desaturase 2 (FADS2; HSA11q12-q13.1) catalyzes the first and rate-limiting step for the biosynthesis of long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	167-194	fatty acid desaturase 2	Homo sapiens	66-71
19116776-1	2009	Liver fatty acid binding protein (L-FABP) is highly expressed in both enterocytes and hepatocytes and binds multiple ligands, including saturated (SFA), unsaturated fatty acids (PUFA), and cholesterol.	Fatty Acids, Unsaturated	153-176	fatty acid binding protein 1, liver	Mus musculus	0-32
19398230-0	2009	Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN.	Fatty Acids, Unsaturated	0-23	phosphatase and tensin homolog	Mus musculus	118-122
19398230-2	2009	We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes.	Fatty Acids, Unsaturated	30-53	phosphatase and tensin homolog	Mus musculus	105-109
19398230-2	2009	We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes.	Fatty Acids, Unsaturated	30-53	mechanistic target of rapamycin kinase	Mus musculus	121-125
19398230-2	2009	We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes.	Fatty Acids, Unsaturated	30-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	126-135
19398230-3	2009	In this study, we investigated whether unsaturated fatty acids promote hepatoma progression by downregulating PTEN expression.	Fatty Acids, Unsaturated	39-62	phosphatase and tensin homolog	Mus musculus	110-114
19398230-9	2009	CONCLUSIONS: These data demonstrate that dietary unsaturated fatty acids promote hepatoma progression by reducing the expression of the tumor suppressor PTEN.	Fatty Acids, Unsaturated	49-72	phosphatase and tensin homolog	Mus musculus	153-157
19285984-1	2009	Epoxyeicosatrienoic acids (EETs) are polyunsaturated fatty acids synthesized from arachidonic acid by CYP2J2 epoxygenase and inactivated by soluble epoxide hydrolase (sEH or Ephx2) to dihydroxyeicosatrienoic acids.	Fatty Acids, Unsaturated	37-64	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	102-108
19285984-1	2009	Epoxyeicosatrienoic acids (EETs) are polyunsaturated fatty acids synthesized from arachidonic acid by CYP2J2 epoxygenase and inactivated by soluble epoxide hydrolase (sEH or Ephx2) to dihydroxyeicosatrienoic acids.	Fatty Acids, Unsaturated	37-64	epoxide hydrolase 2	Rattus norvegicus	167-170
19285984-1	2009	Epoxyeicosatrienoic acids (EETs) are polyunsaturated fatty acids synthesized from arachidonic acid by CYP2J2 epoxygenase and inactivated by soluble epoxide hydrolase (sEH or Ephx2) to dihydroxyeicosatrienoic acids.	Fatty Acids, Unsaturated	37-64	epoxide hydrolase 2	Rattus norvegicus	174-179
19116776-1	2009	Liver fatty acid binding protein (L-FABP) is highly expressed in both enterocytes and hepatocytes and binds multiple ligands, including saturated (SFA), unsaturated fatty acids (PUFA), and cholesterol.	Fatty Acids, Unsaturated	153-176	fatty acid binding protein 1, liver	Mus musculus	34-40
19116776-1	2009	Liver fatty acid binding protein (L-FABP) is highly expressed in both enterocytes and hepatocytes and binds multiple ligands, including saturated (SFA), unsaturated fatty acids (PUFA), and cholesterol.	Fatty Acids, Unsaturated	178-182	fatty acid binding protein 1, liver	Mus musculus	0-32
19116776-1	2009	Liver fatty acid binding protein (L-FABP) is highly expressed in both enterocytes and hepatocytes and binds multiple ligands, including saturated (SFA), unsaturated fatty acids (PUFA), and cholesterol.	Fatty Acids, Unsaturated	178-182	fatty acid binding protein 1, liver	Mus musculus	34-40
19628101-3	2009	This study aimed to assess the association between PUFA intake and serum C-reactive protein (CRP) concentrations in a group of Japanese employees.	Fatty Acids, Unsaturated	51-55	C-reactive protein	Homo sapiens	73-91
19628101-3	2009	This study aimed to assess the association between PUFA intake and serum C-reactive protein (CRP) concentrations in a group of Japanese employees.	Fatty Acids, Unsaturated	51-55	C-reactive protein	Homo sapiens	93-96
19538315-5	2009	Polyunsaturated fatty acids (PUFA) improve paracellular permeability after IL-4 incubation.	Fatty Acids, Unsaturated	0-27	interleukin 4	Homo sapiens	75-79
19538315-5	2009	Polyunsaturated fatty acids (PUFA) improve paracellular permeability after IL-4 incubation.	Fatty Acids, Unsaturated	29-33	interleukin 4	Homo sapiens	75-79
19675375-7	2009	Data suggest that dietary omega-3 polyunsaturated fatty acids (PUFAs) improve lipid profile and may have beneficial effect on insulin resistance.	Fatty Acids, Unsaturated	63-68	insulin	Homo sapiens	126-133
18848326-5	2009	It was observed that feeding of diets with n-6 PUFA or a combination of n-6 and n-3 PUFAs resulted in marked elevation of plasma levels of total as well as HDL cholesterol and triglycerides in obese rats (BII and BIII), as compared to the control group (BI).	Fatty Acids, Unsaturated	84-89	calcium voltage-gated channel subunit alpha1 B	Rattus norvegicus	213-217
19323467-6	2009	In particular, IL-10-/-mice were characterized by decreased levels of VLDL and increased concentrations of LDL and polyunsaturated fatty acids, which are related to the etiology of IBD.	Fatty Acids, Unsaturated	115-142	interleukin 10	Mus musculus	15-20
19017686-3	2009	A number of fatty acids such as polyunsaturated fatty acids or eicosanoids are considered as endogenous PPAR gamma activators.	Fatty Acids, Unsaturated	32-59	peroxisome proliferator activated receptor gamma	Homo sapiens	104-114
19244244-6	2009	Ygr110wp has a strong substrate preference for palmitic acid residues and functions upstream of Taz1p, to generate monolysocardiolipin for Taz1p-dependent reacylation with unsaturated fatty acids.	Fatty Acids, Unsaturated	172-195	lysophosphatidylcholine acyltransferase	Saccharomyces cerevisiae S288C	96-101
19244244-6	2009	Ygr110wp has a strong substrate preference for palmitic acid residues and functions upstream of Taz1p, to generate monolysocardiolipin for Taz1p-dependent reacylation with unsaturated fatty acids.	Fatty Acids, Unsaturated	172-195	lysophosphatidylcholine acyltransferase	Saccharomyces cerevisiae S288C	139-144
19089921-1	2009	The enzyme 15-lipoxygenase-2 (15-LOX-2) utilizes arachidonic acid, a polyunsaturated fatty acid, to synthesize 15(S)-hydroxyeicosatetraenoic acid.	Fatty Acids, Unsaturated	69-95	arachidonate 15-lipoxygenase type B	Homo sapiens	11-28
19089921-1	2009	The enzyme 15-lipoxygenase-2 (15-LOX-2) utilizes arachidonic acid, a polyunsaturated fatty acid, to synthesize 15(S)-hydroxyeicosatetraenoic acid.	Fatty Acids, Unsaturated	69-95	arachidonate 15-lipoxygenase type B	Homo sapiens	30-38
19072831-0	2009	Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes.	Fatty Acids, Unsaturated	0-23	phosphatase and tensin homolog	Homo sapiens	99-103
19072831-0	2009	Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes.	Fatty Acids, Unsaturated	0-23	microRNA 21	Homo sapiens	109-120
19072831-3	2009	We recently demonstrated that unsaturated fatty acids trigger steatosis by down-regulating PTEN expression in hepatocytes via activation of a mammalian target of rapamycin (mTOR)/nuclear factor kappa B (NF-kappaB) complex, but the molecular mechanisms implicated in this process are still unknown.	Fatty Acids, Unsaturated	30-53	phosphatase and tensin homolog	Homo sapiens	91-95
19072831-3	2009	We recently demonstrated that unsaturated fatty acids trigger steatosis by down-regulating PTEN expression in hepatocytes via activation of a mammalian target of rapamycin (mTOR)/nuclear factor kappa B (NF-kappaB) complex, but the molecular mechanisms implicated in this process are still unknown.	Fatty Acids, Unsaturated	30-53	mechanistic target of rapamycin kinase	Homo sapiens	142-171
19072831-3	2009	We recently demonstrated that unsaturated fatty acids trigger steatosis by down-regulating PTEN expression in hepatocytes via activation of a mammalian target of rapamycin (mTOR)/nuclear factor kappa B (NF-kappaB) complex, but the molecular mechanisms implicated in this process are still unknown.	Fatty Acids, Unsaturated	30-53	mechanistic target of rapamycin kinase	Homo sapiens	173-177
19072831-3	2009	We recently demonstrated that unsaturated fatty acids trigger steatosis by down-regulating PTEN expression in hepatocytes via activation of a mammalian target of rapamycin (mTOR)/nuclear factor kappa B (NF-kappaB) complex, but the molecular mechanisms implicated in this process are still unknown.	Fatty Acids, Unsaturated	30-53	nuclear factor kappa B subunit 1	Homo sapiens	203-212
19072831-5	2009	Our results indicate that unsaturated fatty acids down-regulate PTEN messenger RNA expression in hepatocytes through mechanisms unrelated to methylation of the PTEN promoter, histone deacetylase activities, or repression of the PTEN promoter activity.	Fatty Acids, Unsaturated	26-49	phosphatase and tensin homolog	Homo sapiens	64-68
19072831-6	2009	In contrast, unsaturated fatty acids up-regulate the expression of microRNA-21, which binds to PTEN messenger RNA 3"-untranslated region and induces its degradation.	Fatty Acids, Unsaturated	13-36	microRNA 21	Homo sapiens	67-78
19072831-6	2009	In contrast, unsaturated fatty acids up-regulate the expression of microRNA-21, which binds to PTEN messenger RNA 3"-untranslated region and induces its degradation.	Fatty Acids, Unsaturated	13-36	phosphatase and tensin homolog	Homo sapiens	95-99
19072831-9	2009	CONCLUSION: Unsaturated fatty acids inhibit PTEN expression in hepatocytes by up-regulating microRNA-21 synthesis via an mTOR/NF-kappaB-dependent mechanism.	Fatty Acids, Unsaturated	12-35	phosphatase and tensin homolog	Homo sapiens	44-48
19072831-9	2009	CONCLUSION: Unsaturated fatty acids inhibit PTEN expression in hepatocytes by up-regulating microRNA-21 synthesis via an mTOR/NF-kappaB-dependent mechanism.	Fatty Acids, Unsaturated	12-35	microRNA 21	Homo sapiens	92-103
19072831-9	2009	CONCLUSION: Unsaturated fatty acids inhibit PTEN expression in hepatocytes by up-regulating microRNA-21 synthesis via an mTOR/NF-kappaB-dependent mechanism.	Fatty Acids, Unsaturated	12-35	mechanistic target of rapamycin kinase	Homo sapiens	121-125
19072831-9	2009	CONCLUSION: Unsaturated fatty acids inhibit PTEN expression in hepatocytes by up-regulating microRNA-21 synthesis via an mTOR/NF-kappaB-dependent mechanism.	Fatty Acids, Unsaturated	12-35	nuclear factor kappa B subunit 1	Homo sapiens	126-135
19367763-0	2009	Cytosolic phospholipase A2-driven PGE2 synthesis within unsaturated fatty acids-induced lipid bodies of epithelial cells.	Fatty Acids, Unsaturated	56-79	phospholipase A2 group IVA	Rattus norvegicus	0-26
19367763-5	2009	Stimulation of confluent IEC-6 cells with unsaturated fatty acids, including AA or oleic acid (OA), induced rapid lipid body assembly that was independent on its metabolism to PGE(2), but dependent on G-coupled receptor-driven signaling through p38, PKC, and PI3 K. Newly formed lipid bodies compartmentalized cytosolic phospholipase (cPL)A(2)-alpha, while facilitated AA mobilization and synthesis of PGE(2) within epithelial cells.	Fatty Acids, Unsaturated	42-65	mitogen activated protein kinase 14	Rattus norvegicus	245-248
19367763-5	2009	Stimulation of confluent IEC-6 cells with unsaturated fatty acids, including AA or oleic acid (OA), induced rapid lipid body assembly that was independent on its metabolism to PGE(2), but dependent on G-coupled receptor-driven signaling through p38, PKC, and PI3 K. Newly formed lipid bodies compartmentalized cytosolic phospholipase (cPL)A(2)-alpha, while facilitated AA mobilization and synthesis of PGE(2) within epithelial cells.	Fatty Acids, Unsaturated	42-65	protein kinase C, gamma	Rattus norvegicus	250-253
19175415-6	2009	The accumulation of ergosterol and unsaturated fatty acids was accompanied by the expression of ERG1, ERG11 and OLE1.	Fatty Acids, Unsaturated	35-58	squalene monooxygenase	Saccharomyces cerevisiae S288C	96-100
19202385-1	2009	PURPOSE OF REVIEW: Review results from recent human and animal studies regarding the effects of n-3 polyunsaturated fatty acid (PUFA) in the prevention of insulin resistance.	Fatty Acids, Unsaturated	128-132	insulin	Homo sapiens	155-162
18449536-3	2009	There is clear evidence for TREK-1 and TASK-1 in the heart and these channels are likely to regulate cardiac action potential duration through their regulation by stretch, polyunsaturated fatty acids, pH, and neurotransmitters.	Fatty Acids, Unsaturated	172-199	potassium two pore domain channel subfamily K member 2	Homo sapiens	28-34
18449536-4	2009	TREK-1 may also have a critical role in mediating the vasodilator response of resistance arteries to polyunsaturated fatty acids, thus contributing to their protective effect on the cardiovascular system.	Fatty Acids, Unsaturated	101-128	potassium two pore domain channel subfamily K member 2	Homo sapiens	0-6
19056481-1	2009	Farnesyl diphosphate synthetase (FDPS) is a key enzyme in the isoprenoid pathway responsible for cholesterol biosynthesis, post-translational protein modifications and synthesis of steroid hormones, whose expression is regulated by phorbol esters and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	251-278	farnesyl diphosphate synthase	Homo sapiens	0-31
19056481-1	2009	Farnesyl diphosphate synthetase (FDPS) is a key enzyme in the isoprenoid pathway responsible for cholesterol biosynthesis, post-translational protein modifications and synthesis of steroid hormones, whose expression is regulated by phorbol esters and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	251-278	farnesyl diphosphate synthase	Homo sapiens	33-37
19175415-6	2009	The accumulation of ergosterol and unsaturated fatty acids was accompanied by the expression of ERG1, ERG11 and OLE1.	Fatty Acids, Unsaturated	35-58	sterol 14-demethylase	Saccharomyces cerevisiae S288C	102-107
19175415-6	2009	The accumulation of ergosterol and unsaturated fatty acids was accompanied by the expression of ERG1, ERG11 and OLE1.	Fatty Acids, Unsaturated	35-58	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	112-116
19141698-0	2009	Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia.	Fatty Acids, Unsaturated	0-27	transcription factor 7 like 2	Homo sapiens	51-57
19233806-1	2009	Polyphenol oxidase (PPO) in conditioned red clover (ensiled or cut and crushed) reduces both proteolysis and lipolysis in the herbage, which has led to increases in N use efficiency and polyunsaturated fatty acid (PUFA) content of milk when offered to dairy cows.	Fatty Acids, Unsaturated	186-212	protoporphyrinogen oxidase	Bos taurus	20-23
19233807-7	2009	The concentrations of protein, milk fat, and the shorter chain saturated fatty acids decreased, whereas C18 polyunsaturated fatty acids (PUFA) and long-chain PUFA (C20+) increased as the proportion of red clover in the diet increased.	Fatty Acids, Unsaturated	108-135	PUFA	Bos taurus	137-141
18848547-1	2008	Exposure of alpha-synuclein (alphaS), a major component of Lewy bodies in Parkinson"s disease, to polyunsaturated fatty acids (PUFAs) triggers the formation of soluble alphaS oligomers.	Fatty Acids, Unsaturated	98-125	synuclein alpha	Homo sapiens	12-27
19136075-2	2009	Hepatic fatty acid elongase 5 (Elovl5) elongates C18-20 polyunsaturated fatty acids (PUFAs) and is important for biosynthesis of C20-22 PUFAs.	Fatty Acids, Unsaturated	56-83	ELOVL family member 5, elongation of long chain fatty acids (yeast)	Mus musculus	31-37
19136075-2	2009	Hepatic fatty acid elongase 5 (Elovl5) elongates C18-20 polyunsaturated fatty acids (PUFAs) and is important for biosynthesis of C20-22 PUFAs.	Fatty Acids, Unsaturated	85-90	ELOVL family member 5, elongation of long chain fatty acids (yeast)	Mus musculus	31-37
19118492-7	2009	Recently, NO-derived unsaturated fatty acids were found to be potent agonists of PPARs, with preferential affinity for PPARgamma, compared with oxidized fatty acid derivatives.	Fatty Acids, Unsaturated	21-44	peroxisome proliferator activated receptor gamma	Homo sapiens	119-128
19030909-3	2009	AIM OF THE STUDY: The aim of the trial was to study the effect of marine n-3 polyunsaturated fatty acids (PUFA) on plasma Lp-PLA(2) levels in healthy subjects.	Fatty Acids, Unsaturated	106-110	phospholipase A2 group VII	Homo sapiens	122-131
18992836-1	2009	Dietary fatty acid composition, particularly polyunsaturated fatty acids, can affect both genetic and non-genetic regulatory mechanisms of carnitine palmitoyltransferase (CPT) I, the main regulatory enzyme of mitochondrial fatty acid oxidation.	Fatty Acids, Unsaturated	45-72	carnitine palmitoyl transferase I	Oncorhynchus mykiss	139-177
18992836-4	2009	We found that fish fed the high PUFA diet significantly increased CPT I mRNA expression in red muscle, liver and adipose tissue, while PPAR alpha and beta expressions were variable across tissues.	Fatty Acids, Unsaturated	32-36	carnitine palmitoyl transferase I	Oncorhynchus mykiss	66-71
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	109-136	peroxisome proliferator activated receptor alpha	Rattus norvegicus	165-207
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	109-136	peroxisome proliferator activated receptor alpha	Rattus norvegicus	209-213
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	109-136	solute carrier family 27 member 1	Rattus norvegicus	222-257
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	109-136	solute carrier family 27 member 1	Rattus norvegicus	259-263
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	109-136	interleukin 1 receptor antagonist	Rattus norvegicus	269-302
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	109-136	interleukin 1 receptor antagonist	Rattus norvegicus	304-310
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	138-142	peroxisome proliferator activated receptor alpha	Rattus norvegicus	165-207
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	138-142	peroxisome proliferator activated receptor alpha	Rattus norvegicus	209-213
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	138-142	solute carrier family 27 member 1	Rattus norvegicus	222-257
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	138-142	solute carrier family 27 member 1	Rattus norvegicus	259-263
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	138-142	interleukin 1 receptor antagonist	Rattus norvegicus	269-302
19526847-1	2009	In experiments on isolated neonatal cardiomyocytes and hearts of adult rats we investigated the influence of polyunsaturated fatty acids (PUFA) on expression of two peroxisome proliferator-activated receptor (PPAR) target genes--fatty acid transport protein (FATP) and interleukin-1 receptor antagonist (IL-1ra).	Fatty Acids, Unsaturated	138-142	interleukin 1 receptor antagonist	Rattus norvegicus	304-310
19890471-2	2009	Astrocytes express a wide variety of potassium channels to support their functions including TREK-2 channels which are regulated by polyunsaturated fatty acids, intracellular acidosis and swelling; conditions that pertain to ischemia.	Fatty Acids, Unsaturated	132-159	potassium two pore domain channel subfamily K member 10	Homo sapiens	93-99
18823665-7	2008	The heat-, stretch- and lipid-activated TREK-1 channels contribute to temperature and mechanical pain sensation, neuroprotection by polyunsaturated fatty acids and, unexpectedly, mood regulation.	Fatty Acids, Unsaturated	132-159	potassium channel, subfamily K, member 2	Mus musculus	40-46
18838740-7	2009	These studies demonstrate that reduced ELOVL5 activity leads to hepatic steatosis, and endogenously synthesized PUFAs are key regulators of SREBP-1c activation and fatty acid synthesis in livers of mice.	Fatty Acids, Unsaturated	112-117	sterol regulatory element binding transcription factor 1	Mus musculus	140-148
19174160-5	2009	Osmotic swelling is modeled to activate enzyme(s), producing polyunsaturated fatty acids (PUFAs) to open TRPV4 in mammalian cells.	Fatty Acids, Unsaturated	61-88	transient receptor potential cation channel subfamily V member 4	Homo sapiens	105-110
19174160-5	2009	Osmotic swelling is modeled to activate enzyme(s), producing polyunsaturated fatty acids (PUFAs) to open TRPV4 in mammalian cells.	Fatty Acids, Unsaturated	90-95	transient receptor potential cation channel subfamily V member 4	Homo sapiens	105-110
18778245-0	2009	Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.	Fatty Acids, Unsaturated	0-22	nuclear receptor subfamily 1 group I member 3	Homo sapiens	70-73
18778245-5	2009	To our knowledge this is the first direct evidence that P450s play a major role in controlling unsaturated fatty acid homoeostasis via CAR.	Fatty Acids, Unsaturated	95-117	nuclear receptor subfamily 1 group I member 3	Homo sapiens	135-138
18685141-4	2009	Trials with polyunsaturated fatty acids (PUFA) in IgAN have been done since the first successful attempt by Hamazaki in 1984, resulting in alternate answers, but no trials have ever been done testing the efficacy of combined therapy with RASB and PUFA.	Fatty Acids, Unsaturated	12-39	IGAN1	Homo sapiens	50-54
18685141-4	2009	Trials with polyunsaturated fatty acids (PUFA) in IgAN have been done since the first successful attempt by Hamazaki in 1984, resulting in alternate answers, but no trials have ever been done testing the efficacy of combined therapy with RASB and PUFA.	Fatty Acids, Unsaturated	41-45	IGAN1	Homo sapiens	50-54
20300478-3	2009	How steatosis increases PPARalpha activated gene expression of fatty acid transport proteins, peroxisomal and mitochondrial fatty acid beta-oxidation and omega-oxidation of fatty acids genes regardless of whether dietary fatty acids are polyunsaturated (PUFA), monounsaturated (MUFA), or saturated (SFA) may be determined by the interplay of PPARs and HNF4alpha with the fatty acid transport proteins L-FABP and ACBP.	Fatty Acids, Unsaturated	254-258	peroxisome proliferator activated receptor alpha	Mus musculus	24-33
18804128-2	2008	Recently, it was reported that the unsaturated fatty acid alpha-linoleic acid promotes the secretion of GLP-1 via a G protein-coupled receptor, GPR120.	Fatty Acids, Unsaturated	35-57	glucagon	Mus musculus	104-109
18804128-2	2008	Recently, it was reported that the unsaturated fatty acid alpha-linoleic acid promotes the secretion of GLP-1 via a G protein-coupled receptor, GPR120.	Fatty Acids, Unsaturated	35-57	free fatty acid receptor 4	Mus musculus	144-150
22444081-7	2008	Intramuscular polyunsaturated fatty acid (PUFA) content was less susceptible to dietary treatment modifications compared with other depots.	Fatty Acids, Unsaturated	14-40	Polyunsaturated fatty acid percentage	Sus scrofa	42-46
19139003-7	2008	Prepubertal exposure to the high-fat n-3 PUFA diet increased DNA damage and cyclin D1 protein and reduced expression of BRCA1 and cardiotrophin-1.	Fatty Acids, Unsaturated	41-45	cyclin D1	Rattus norvegicus	76-85
19139003-7	2008	Prepubertal exposure to the high-fat n-3 PUFA diet increased DNA damage and cyclin D1 protein and reduced expression of BRCA1 and cardiotrophin-1.	Fatty Acids, Unsaturated	41-45	BRCA1, DNA repair associated	Rattus norvegicus	120-125
19139003-7	2008	Prepubertal exposure to the high-fat n-3 PUFA diet increased DNA damage and cyclin D1 protein and reduced expression of BRCA1 and cardiotrophin-1.	Fatty Acids, Unsaturated	41-45	cardiotrophin 1	Rattus norvegicus	130-145
18657232-1	2008	Delta(3),Delta(2)-enoyl CoA isomerase (ECI) is an enzyme that participates in the degradation of unsaturated fatty acids through the beta-oxidation cycle.	Fatty Acids, Unsaturated	97-120	delta like canonical Notch ligand 3	Homo sapiens	0-37
18835813-0	2008	Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.	Fatty Acids, Unsaturated	0-23	insulin induced gene 1	Homo sapiens	59-66
18835813-3	2008	Here we show that unsaturated fatty acids stabilize Insig-1 without affecting its ubiquitination.	Fatty Acids, Unsaturated	18-41	insulin induced gene 1	Homo sapiens	52-59
18835813-4	2008	Instead unsaturated fatty acids inhibit extraction of ubiquitinated Insig-1 from membranes, a process known to be mediated by valosin-containing protein and necessary for ER-associated degradation.	Fatty Acids, Unsaturated	8-31	insulin induced gene 1	Homo sapiens	68-75
18835813-6	2008	Unsaturated fatty acids block the binding between Ubxd8 and Insig-1, thereby abrogating the membrane extraction of Insig-1.	Fatty Acids, Unsaturated	0-23	Fas associated factor family member 2	Homo sapiens	50-55
18835813-6	2008	Unsaturated fatty acids block the binding between Ubxd8 and Insig-1, thereby abrogating the membrane extraction of Insig-1.	Fatty Acids, Unsaturated	0-23	insulin induced gene 1	Homo sapiens	60-67
18835813-6	2008	Unsaturated fatty acids block the binding between Ubxd8 and Insig-1, thereby abrogating the membrane extraction of Insig-1.	Fatty Acids, Unsaturated	0-23	insulin induced gene 1	Homo sapiens	115-122
18835813-7	2008	Unsaturated fatty acid-mediated stabilization of Insig-1 enhances the ability of sterols to inhibit proteolytic activation of SREBP-1, which activates transcription of genes involved in fatty acid synthesis.	Fatty Acids, Unsaturated	0-22	insulin induced gene 1	Homo sapiens	49-56
18835813-7	2008	Unsaturated fatty acid-mediated stabilization of Insig-1 enhances the ability of sterols to inhibit proteolytic activation of SREBP-1, which activates transcription of genes involved in fatty acid synthesis.	Fatty Acids, Unsaturated	0-22	sterol regulatory element binding transcription factor 1	Homo sapiens	126-133
18848547-1	2008	Exposure of alpha-synuclein (alphaS), a major component of Lewy bodies in Parkinson"s disease, to polyunsaturated fatty acids (PUFAs) triggers the formation of soluble alphaS oligomers.	Fatty Acids, Unsaturated	127-132	synuclein alpha	Homo sapiens	12-27
18560269-3	2008	In what appears to be a normal response to diets rich in polyunsaturated fatty acids, which are readily peroxidized, apoB comes into contact with lipid peroxides in or after the Golgi apparatus.	Fatty Acids, Unsaturated	57-84	apolipoprotein B	Homo sapiens	117-121
18842780-1	2008	BACKGROUND: The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA).	Fatty Acids, Unsaturated	102-128	fatty acid desaturase 1	Homo sapiens	60-65
18842780-1	2008	BACKGROUND: The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA).	Fatty Acids, Unsaturated	102-128	fatty acid desaturase 2	Homo sapiens	70-75
18842780-1	2008	BACKGROUND: The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA).	Fatty Acids, Unsaturated	130-134	fatty acid desaturase 1	Homo sapiens	60-65
18842780-1	2008	BACKGROUND: The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA).	Fatty Acids, Unsaturated	130-134	fatty acid desaturase 2	Homo sapiens	70-75
18585430-4	2008	Other lipids, for instance polyunsaturated fatty acids (PUFA), should be possible candidate substrates for the ABCD2 and ABCD3 gene products, ALDRP and PMP70 respectively.	Fatty Acids, Unsaturated	27-54	ATP binding cassette subfamily D member 2	Rattus norvegicus	111-116
18585430-4	2008	Other lipids, for instance polyunsaturated fatty acids (PUFA), should be possible candidate substrates for the ABCD2 and ABCD3 gene products, ALDRP and PMP70 respectively.	Fatty Acids, Unsaturated	27-54	ATP binding cassette subfamily D member 3	Rattus norvegicus	121-126
18585430-4	2008	Other lipids, for instance polyunsaturated fatty acids (PUFA), should be possible candidate substrates for the ABCD2 and ABCD3 gene products, ALDRP and PMP70 respectively.	Fatty Acids, Unsaturated	27-54	ATP binding cassette subfamily D member 3	Rattus norvegicus	152-157
18585430-4	2008	Other lipids, for instance polyunsaturated fatty acids (PUFA), should be possible candidate substrates for the ABCD2 and ABCD3 gene products, ALDRP and PMP70 respectively.	Fatty Acids, Unsaturated	56-60	ATP binding cassette subfamily D member 2	Rattus norvegicus	111-116
18585430-4	2008	Other lipids, for instance polyunsaturated fatty acids (PUFA), should be possible candidate substrates for the ABCD2 and ABCD3 gene products, ALDRP and PMP70 respectively.	Fatty Acids, Unsaturated	56-60	ATP binding cassette subfamily D member 3	Rattus norvegicus	121-126
18585430-4	2008	Other lipids, for instance polyunsaturated fatty acids (PUFA), should be possible candidate substrates for the ABCD2 and ABCD3 gene products, ALDRP and PMP70 respectively.	Fatty Acids, Unsaturated	56-60	ATP binding cassette subfamily D member 3	Rattus norvegicus	152-157
18256901-4	2008	The FAD3 enzyme is responsible for the synthesis of alpha-linolenic acids (18:3) in the polyunsaturated fatty acid pathway.	Fatty Acids, Unsaturated	88-114	omega-3 fatty acid desaturase, endoplasmic reticulum	Glycine max	4-8
18728184-4	2008	Here, using a gain-of-function approach, we provide direct and compelling evidence that ELOVL4 is required for the synthesis of C28 and C30 saturated fatty acids (VLC-FA) and of C28-C38 very long chain polyunsaturated fatty acids (VLC-PUFA), the latter being uniquely expressed in retina, sperm, and brain.	Fatty Acids, Unsaturated	202-229	ELOVL fatty acid elongase 4	Homo sapiens	88-94
17579652-5	2008	Higher PUFA intake was associated with lower total serum cholesterol (TC, B=-0.13, P=0.003), lower low-density-lipoprotein cholesterol (LDL-C, B=-0.12, P=0.004) and apolipoprotein B (B=-0.03) (P=0.034) in girls but not in boys.	Fatty Acids, Unsaturated	7-11	apolipoprotein B	Homo sapiens	165-181
18716213-3	2008	Recently, we demonstrated that A-kinase anchoring protein AKAP150 binds to a major regulatory domain of TREK-1, promoting drastic changes in channel regulation by polyunsaturated fatty acids, pH, and stretch, and by G-protein-coupled receptors to neurotransmitters and hormones.	Fatty Acids, Unsaturated	163-190	potassium two pore domain channel subfamily K member 2	Homo sapiens	104-110
18619556-1	2008	Polyunsaturated fatty acids can be omega-oxidized to dicarboxylic polyunsaturated fatty acids (DC-PUFA), bioactive compounds which cause vasodilatation and activation of PPARalpha and gamma.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Mus musculus	170-179
18619556-1	2008	Polyunsaturated fatty acids can be omega-oxidized to dicarboxylic polyunsaturated fatty acids (DC-PUFA), bioactive compounds which cause vasodilatation and activation of PPARalpha and gamma.	Fatty Acids, Unsaturated	66-93	peroxisome proliferator activated receptor alpha	Mus musculus	170-179
18650299-1	2008	The endogenous production of unsaturated fatty acids (FA), particularly some monounsaturated FA (%MONO) and nearly all conjugated linoleic acids, is regulated by the Delta(9)-desaturase activity.	Fatty Acids, Unsaturated	29-52	stearoyl-CoA desaturase	Bos taurus	166-185
18797151-2	2008	In this study, we demonstrated that the induction of conformational change and transactivity of PPAR delta by arachidonic acid, as well as other polyunsaturated fatty acids, was considerably lower than that of PPAR alpha.	Fatty Acids, Unsaturated	145-172	peroxisome proliferator activated receptor delta	Homo sapiens	96-106
18664600-5	2008	Unsaturated fatty acid composition of hepatic triglycerides was modified in fasted HSL-null mice on ND and HFD.	Fatty Acids, Unsaturated	0-22	lipase, hormone sensitive	Mus musculus	83-86
18771750-1	2008	Rsp5p, a yeast S. cerevisiae ubiquitin ligase, is essential for regulation of unsaturated fatty acid synthesis via activation of the transcriptional activators Spt23p and Mga2p.	Fatty Acids, Unsaturated	78-100	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	0-5
18771750-1	2008	Rsp5p, a yeast S. cerevisiae ubiquitin ligase, is essential for regulation of unsaturated fatty acid synthesis via activation of the transcriptional activators Spt23p and Mga2p.	Fatty Acids, Unsaturated	78-100	Spt23p	Saccharomyces cerevisiae S288C	160-166
18771750-1	2008	Rsp5p, a yeast S. cerevisiae ubiquitin ligase, is essential for regulation of unsaturated fatty acid synthesis via activation of the transcriptional activators Spt23p and Mga2p.	Fatty Acids, Unsaturated	78-100	Mga2p	Saccharomyces cerevisiae S288C	171-176
18702940-4	2008	Serum levels of ET-1 were positively correlated with saturated fatty acids (r = 0.257, P = .025) and negatively correlated with polyunsaturated fatty acids (PUFAs) (r = -0.319, P = .005).	Fatty Acids, Unsaturated	128-155	endothelin 1	Homo sapiens	16-20
18702940-4	2008	Serum levels of ET-1 were positively correlated with saturated fatty acids (r = 0.257, P = .025) and negatively correlated with polyunsaturated fatty acids (PUFAs) (r = -0.319, P = .005).	Fatty Acids, Unsaturated	157-162	endothelin 1	Homo sapiens	16-20
18702940-6	2008	In multiple linear regression models, only saturated fatty acids (R(2) = 0.317, P = .002) or PUFAs (R(2) = 0.314, P = .001) remained associated with ET-1 levels.	Fatty Acids, Unsaturated	93-98	endothelin 1	Homo sapiens	149-153
18782225-4	2008	In this study, we found that knockdown of another member of the MBOAT family in C. elegans, named mboa-6, reduced incorporation of exogenous PUFAs into phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE) in C. elegans.	Fatty Acids, Unsaturated	141-146	Lysophospholipid acyltransferase 5	Caenorhabditis elegans	98-104
18522410-2	2008	The objective of this article was to determine the lipid composition of the milk fat globule membrane (MFGM) of milk from cows fed a diet rich in polyunsaturated fatty acids.	Fatty Acids, Unsaturated	146-173	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	76-101
18522410-2	2008	The objective of this article was to determine the lipid composition of the milk fat globule membrane (MFGM) of milk from cows fed a diet rich in polyunsaturated fatty acids.	Fatty Acids, Unsaturated	146-173	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	103-107
18522410-7	2008	MFGM in milk from cows fed the diet rich in polyunsaturated FA resulted in (i) a higher amount of phospholipids (+ 18%), which was related to a smaller size of milk fat globules (ii) an increase of 30% (w/w) of the concentration in sphingomyelin, (iii) a higher content in stearic acid (1.7-fold), unsaturated FA (1.36-fold), and C18:1 trans FA: 7.2 +/- 0.5% (3.7-fold).	Fatty Acids, Unsaturated	44-62	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	0-4
18522410-7	2008	MFGM in milk from cows fed the diet rich in polyunsaturated FA resulted in (i) a higher amount of phospholipids (+ 18%), which was related to a smaller size of milk fat globules (ii) an increase of 30% (w/w) of the concentration in sphingomyelin, (iii) a higher content in stearic acid (1.7-fold), unsaturated FA (1.36-fold), and C18:1 trans FA: 7.2 +/- 0.5% (3.7-fold).	Fatty Acids, Unsaturated	48-62	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	0-4
18402553-9	2008	Biochemical analysis of transgenic plants with regards to fatty acids associated with relevant lipids indicates that lipids increasing with PIS1 overexpression were enriched in saturated or monounsaturated fatty acids, whereas lipids increasing with PIS2 overexpression, including polyphosphoinositides, contained more unsaturated fatty acids.	Fatty Acids, Unsaturated	194-217	phosphatidylinositol synthase 1	Arabidopsis thaliana	140-144
18395968-1	2008	Polyunsaturated fatty acids (PUFAs) induce COX-2 in bovine endometrial stromal cells through activation of peroxisome-proliferator-activated receptor alpha (PPARalpha).	Fatty Acids, Unsaturated	0-27	cytochrome c oxidase subunit II	Bos taurus	43-48
18414994-1	2008	Previous studies show that treatment with a polyunsaturated fatty acid, arachidonic acid (AA), or high concentrations of cycloleucine, an inhibitor of methionine adenosyltransferase (MAT), which lowers levels of S-adenosyl-L-methionine (SAM), increased toxicity in hepatocytes from pyrazole-treated rats which expressed high levels of cytochrome P450 2E1 (CYP2E1).	Fatty Acids, Unsaturated	44-70	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	335-354
18414994-1	2008	Previous studies show that treatment with a polyunsaturated fatty acid, arachidonic acid (AA), or high concentrations of cycloleucine, an inhibitor of methionine adenosyltransferase (MAT), which lowers levels of S-adenosyl-L-methionine (SAM), increased toxicity in hepatocytes from pyrazole-treated rats which expressed high levels of cytochrome P450 2E1 (CYP2E1).	Fatty Acids, Unsaturated	44-70	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	356-362
18339646-7	2008	K+ outward currents displaying the characteristics of TREK-1 were observed following various TREK-1-activating stimuli such as membrane stretch, intracellular acidosis, polyunsaturated fatty acids, isoflurane (ISOFL), riluzole, and acetylcholine (ACh).	Fatty Acids, Unsaturated	169-196	potassium channel, subfamily K, member 2	Mus musculus	54-60
18448313-0	2008	Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: a putative mechanism of antiseizure action.	Fatty Acids, Unsaturated	0-27	potassium voltage-gated channel subfamily D member 3	Homo sapiens	95-118
18376007-1	2008	Hepatic fatty acid elongase-5 (Elovl-5) plays an important role in long chain monounsaturated and polyunsaturated fatty acid synthesis.	Fatty Acids, Unsaturated	98-124	ELOVL family member 5, elongation of long chain fatty acids (yeast)	Mus musculus	31-38
18395968-1	2008	Polyunsaturated fatty acids (PUFAs) induce COX-2 in bovine endometrial stromal cells through activation of peroxisome-proliferator-activated receptor alpha (PPARalpha).	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Bos taurus	107-155
18395968-1	2008	Polyunsaturated fatty acids (PUFAs) induce COX-2 in bovine endometrial stromal cells through activation of peroxisome-proliferator-activated receptor alpha (PPARalpha).	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Bos taurus	157-166
18395968-1	2008	Polyunsaturated fatty acids (PUFAs) induce COX-2 in bovine endometrial stromal cells through activation of peroxisome-proliferator-activated receptor alpha (PPARalpha).	Fatty Acids, Unsaturated	29-34	cytochrome c oxidase subunit II	Bos taurus	43-48
18395968-1	2008	Polyunsaturated fatty acids (PUFAs) induce COX-2 in bovine endometrial stromal cells through activation of peroxisome-proliferator-activated receptor alpha (PPARalpha).	Fatty Acids, Unsaturated	29-34	peroxisome proliferator activated receptor alpha	Bos taurus	107-155
18395968-1	2008	Polyunsaturated fatty acids (PUFAs) induce COX-2 in bovine endometrial stromal cells through activation of peroxisome-proliferator-activated receptor alpha (PPARalpha).	Fatty Acids, Unsaturated	29-34	peroxisome proliferator activated receptor alpha	Bos taurus	157-166
18541586-2	2008	The binding of polyunsaturated fatty acids (PUFAs) to PPARA results in rapid changes in the expression of genes involved in lipid oxidation, with long-chain n-3 fatty acids being potent activators of PPARA.	Fatty Acids, Unsaturated	15-42	peroxisome proliferator activated receptor alpha	Homo sapiens	54-59
18541586-2	2008	The binding of polyunsaturated fatty acids (PUFAs) to PPARA results in rapid changes in the expression of genes involved in lipid oxidation, with long-chain n-3 fatty acids being potent activators of PPARA.	Fatty Acids, Unsaturated	15-42	peroxisome proliferator activated receptor alpha	Homo sapiens	200-205
18541586-2	2008	The binding of polyunsaturated fatty acids (PUFAs) to PPARA results in rapid changes in the expression of genes involved in lipid oxidation, with long-chain n-3 fatty acids being potent activators of PPARA.	Fatty Acids, Unsaturated	44-49	peroxisome proliferator activated receptor alpha	Homo sapiens	54-59
18541586-2	2008	The binding of polyunsaturated fatty acids (PUFAs) to PPARA results in rapid changes in the expression of genes involved in lipid oxidation, with long-chain n-3 fatty acids being potent activators of PPARA.	Fatty Acids, Unsaturated	44-49	peroxisome proliferator activated receptor alpha	Homo sapiens	200-205
18497998-0	2008	Polyunsaturated fatty acids support epithelial barrier integrity and reduce IL-4 mediated permeability in vitro.	Fatty Acids, Unsaturated	0-27	interleukin 4	Homo sapiens	76-80
18541015-0	2008	Nutritional skewing of conceptus sex in sheep: effects of a maternal diet enriched in rumen-protected polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	102-129	PUFA	Ovis aries	131-135
18460914-10	2008	SUMMARY: These studies have revealed unique mechanisms by which specific polyunsaturated fatty acids control peroxisome proliferator activated receptor alpha, sterol regulatory element binding protein-1 and carbohydrate regulatory element binding protein/Max-like factor X function.	Fatty Acids, Unsaturated	73-100	peroxisome proliferator activated receptor alpha	Homo sapiens	109-157
18460914-10	2008	SUMMARY: These studies have revealed unique mechanisms by which specific polyunsaturated fatty acids control peroxisome proliferator activated receptor alpha, sterol regulatory element binding protein-1 and carbohydrate regulatory element binding protein/Max-like factor X function.	Fatty Acids, Unsaturated	73-100	sterol regulatory element binding transcription factor 1	Homo sapiens	159-202
18400717-12	2008	Addition of GW9662 reversed the effect of troglitazone and PUFAs at 0.1 mumol/L on IL-8 production and decreased the expression of PPARgamma.	Fatty Acids, Unsaturated	59-64	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
18395405-1	2008	The aim of this study was to investigate whether the toxicity of saturated and polyunsaturated fatty acids (PUFA) on RINm5F cells is related to the phosphorylation state of Akt, ERK and PKC delta.	Fatty Acids, Unsaturated	108-112	AKT serine/threonine kinase 1	Rattus norvegicus	173-176
18395405-1	2008	The aim of this study was to investigate whether the toxicity of saturated and polyunsaturated fatty acids (PUFA) on RINm5F cells is related to the phosphorylation state of Akt, ERK and PKC delta.	Fatty Acids, Unsaturated	108-112	Eph receptor B1	Rattus norvegicus	178-181
18442502-8	2008	CONCLUSIONS: Polyunsaturated fatty acid and simple carbohydrates may be associated with MSDR and insulin resistance in American Indians and sex may modify the association between dietary intake and MS and insulin resistance in this population.	Fatty Acids, Unsaturated	13-39	insulin	Homo sapiens	97-104
18442502-8	2008	CONCLUSIONS: Polyunsaturated fatty acid and simple carbohydrates may be associated with MSDR and insulin resistance in American Indians and sex may modify the association between dietary intake and MS and insulin resistance in this population.	Fatty Acids, Unsaturated	13-39	insulin	Homo sapiens	205-212
18400717-1	2008	BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a role in the regulation of intestinal inflammation and is activated by both natural (polyunsaturated fatty acid; PUFAs) and synthetic (troglitazone) ligands.	Fatty Acids, Unsaturated	165-191	peroxisome proliferator activated receptor gamma	Homo sapiens	12-60
18400717-1	2008	BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a role in the regulation of intestinal inflammation and is activated by both natural (polyunsaturated fatty acid; PUFAs) and synthetic (troglitazone) ligands.	Fatty Acids, Unsaturated	165-191	peroxisome proliferator activated receptor gamma	Homo sapiens	62-71
18400717-4	2008	DESIGN: The human enterocyte-like cell line Caco-2 and human dendritic cells were stimulated by interleukin (IL) 1beta and lipoprotein polysaccharide, respectively, in the presence of PPARgamma agonists (troglitazone or PUFAs) or antagonist (GW9662).	Fatty Acids, Unsaturated	220-225	peroxisome proliferator activated receptor gamma	Homo sapiens	184-193
18270209-8	2008	Increased levels of cholesterol, ceramide and polyunsaturated fatty acids were also detected in the lungs and spleen of Neu4(-/-) mice by high-resolution NMR spectroscopy.	Fatty Acids, Unsaturated	46-73	sialidase 4	Mus musculus	120-124
18356536-0	2008	Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells.	Fatty Acids, Unsaturated	0-27	PCNA clamp associated factor	Rattus norvegicus	34-60
18356536-0	2008	Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells.	Fatty Acids, Unsaturated	0-27	AKT serine/threonine kinase 1	Rattus norvegicus	99-102
18442503-0	2008	Reduce simple carbohydrate and animal protein intake and increase polyunsaturated fatty acid intake in patients with metabolic syndrome and insulin resistance.	Fatty Acids, Unsaturated	66-92	insulin	Homo sapiens	140-147
18435438-1	2008	Certain unsaturated fatty acids (UFAs), cleaved from lipoproteins, are known to activate the serine/threonine protein phosphatase type 2C (PP2C) alpha- and beta-isoforms.	Fatty Acids, Unsaturated	8-31	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	139-150
18435438-1	2008	Certain unsaturated fatty acids (UFAs), cleaved from lipoproteins, are known to activate the serine/threonine protein phosphatase type 2C (PP2C) alpha- and beta-isoforms.	Fatty Acids, Unsaturated	33-37	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	139-150
18435438-4	2008	We demonstrated that LPL from THP-1 macrophages released UFAs from VLDL, which were capable of inducing apoptosis in HUVECs.	Fatty Acids, Unsaturated	57-61	lipoprotein lipase	Homo sapiens	21-24
18435438-4	2008	We demonstrated that LPL from THP-1 macrophages released UFAs from VLDL, which were capable of inducing apoptosis in HUVECs.	Fatty Acids, Unsaturated	57-61	GLI family zinc finger 2	Homo sapiens	30-35
18320251-0	2008	SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease.	Fatty Acids, Unsaturated	50-77	muscle associated receptor tyrosine kinase	Homo sapiens	12-16
18032633-3	2008	High n-3 PUFA dietary consumption completely prevented the MPTP-induced decrease of tyrosine hydroxylase (TH)-labeled nigral cells (P&lt;0.01 vs. MPTP mice on control diet), Nurr1 mRNA (P&lt;0.01 vs. MPTP mice on control diet), and dopamine transporter mRNA levels (P&lt;0.05 vs. MPTP mice on control diet) in the substantia nigra.	Fatty Acids, Unsaturated	9-13	nuclear receptor subfamily 4, group A, member 2	Mus musculus	174-179
18311774-9	2008	They were also independently associated, together with dietary polyunsaturated fatty acid intake, with postprandial adiponectin response.	Fatty Acids, Unsaturated	63-89	adiponectin, C1Q and collagen domain containing	Homo sapiens	116-127
18216296-5	2008	The cyclooxygenase (COX)-mediated conversion of PUFAs to prostanoid derivatives participated in modulation of the expression of Ang2.	Fatty Acids, Unsaturated	48-53	angiopoietin 2	Homo sapiens	128-132
18349237-0	2008	Dietary unsaturated fatty acids increase plasma glucagon-like peptide-1 and cholecystokinin and may decrease premeal ghrelin in lactating dairy cows.	Fatty Acids, Unsaturated	8-31	cholecystokinin	Bos taurus	76-91
18349237-0	2008	Dietary unsaturated fatty acids increase plasma glucagon-like peptide-1 and cholecystokinin and may decrease premeal ghrelin in lactating dairy cows.	Fatty Acids, Unsaturated	8-31	ghrelin and obestatin prepropeptide	Bos taurus	117-124
18320251-1	2008	Polymorphisms of the human Delta-5 (FADS1) and Delta-6 (FADS2) desaturase genes have been recently described to be associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.	Fatty Acids, Unsaturated	175-202	fatty acid desaturase 1	Homo sapiens	36-41
18320251-1	2008	Polymorphisms of the human Delta-5 (FADS1) and Delta-6 (FADS2) desaturase genes have been recently described to be associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.	Fatty Acids, Unsaturated	175-202	fatty acid desaturase 2	Homo sapiens	56-61
18320251-1	2008	Polymorphisms of the human Delta-5 (FADS1) and Delta-6 (FADS2) desaturase genes have been recently described to be associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.	Fatty Acids, Unsaturated	204-209	fatty acid desaturase 1	Homo sapiens	36-41
18320251-1	2008	Polymorphisms of the human Delta-5 (FADS1) and Delta-6 (FADS2) desaturase genes have been recently described to be associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.	Fatty Acids, Unsaturated	204-209	fatty acid desaturase 2	Homo sapiens	56-61
18182022-0	2008	Enzymatic, but not non-enzymatic, 1O2-mediated peroxidation of polyunsaturated fatty acids forms part of the EXECUTER1-dependent stress response program in the flu mutant of Arabidopsis thaliana.	Fatty Acids, Unsaturated	63-90	UvrB/UvrC domain protein (DUF3506)	Arabidopsis thaliana	109-118
18262390-9	2008	TNF-alpha decreased on the high saturated:unsaturated fatty acid treatment (treatment by time, P &lt; 0.05).	Fatty Acids, Unsaturated	42-64	tumor necrosis factor	Homo sapiens	0-9
18484123-1	2008	This study was conducted to evaluate if supplementing bypass fat to cows under silvopastoral systems, increases the concentration of unsaturated fatty acids in milk, thus improving the saturated/ unsaturated ratio without a negative effect on total milk yield in fat or protein.	Fatty Acids, Unsaturated	133-156	Weaning weight-maternal milk	Bos taurus	160-164
18195019-4	2008	Membranes from HEK293 cells overexpressing LPCAT3 showed significantly increased LPCAT activity as assessed by thin layer chromatography analysis with substrate preference toward unsaturated fatty acids.	Fatty Acids, Unsaturated	179-202	lysophosphatidylcholine acyltransferase 3	Homo sapiens	43-48
18191634-0	2008	Unsaturated fatty acids promote proliferation via ERK1/2 and Akt pathway in bovine mammary epithelial cells.	Fatty Acids, Unsaturated	0-23	mitogen-activated protein kinase 3	Bos taurus	50-56
18195019-4	2008	Membranes from HEK293 cells overexpressing LPCAT3 showed significantly increased LPCAT activity as assessed by thin layer chromatography analysis with substrate preference toward unsaturated fatty acids.	Fatty Acids, Unsaturated	179-202	lysophosphatidylcholine acyltransferase 3	Homo sapiens	43-49
18191634-0	2008	Unsaturated fatty acids promote proliferation via ERK1/2 and Akt pathway in bovine mammary epithelial cells.	Fatty Acids, Unsaturated	0-23	AKT serine/threonine kinase 1	Bos taurus	61-64
18094042-0	2008	Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol.	Fatty Acids, Unsaturated	104-131	Lysophospholipid acyltransferase 7	Caenorhabditis elegans	23-29
18320257-0	2008	Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha.	Fatty Acids, Unsaturated	90-117	aminocarboxymuconate semialdehyde decarboxylase	Rattus norvegicus	19-86
18320257-2	2008	Dietary polyunsaturated fatty acids (PUFA) have been shown to suppress hepatic ACMSD activity and its mRNA level in rat.	Fatty Acids, Unsaturated	8-35	aminocarboxymuconate semialdehyde decarboxylase	Rattus norvegicus	79-84
18320257-2	2008	Dietary polyunsaturated fatty acids (PUFA) have been shown to suppress hepatic ACMSD activity and its mRNA level in rat.	Fatty Acids, Unsaturated	37-41	aminocarboxymuconate semialdehyde decarboxylase	Rattus norvegicus	79-84
18320257-6	2008	METHODS: For this purpose we investigated the effect of PUFA (linoleic acid and eicosapentanoic acid) on the ACMSD mRNA level in primary-cultured rat hepatocytes and compared its effect with that of WY-14,643 (a PPARalpha agonist).	Fatty Acids, Unsaturated	56-60	aminocarboxymuconate semialdehyde decarboxylase	Rattus norvegicus	109-114
18288374-0	2008	Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction.	Fatty Acids, Unsaturated	21-48	chromatin licensing and DNA replication factor 1	Homo sapiens	52-56
18288374-0	2008	Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction.	Fatty Acids, Unsaturated	21-48	geminin DNA replication inhibitor	Homo sapiens	57-64
18094042-7	2008	Incorporation of exogenous PUFA into PI of the living worms and LPIAT activity in the microsomes were greatly reduced in mboa-7 mutants.	Fatty Acids, Unsaturated	27-31	Lysophospholipid acyltransferase 7	Caenorhabditis elegans	121-127
18301758-6	2008	Importantly, almost every single gene regulated by dietary unsaturated fatty acids remained unaltered in mice lacking PPARalpha.	Fatty Acids, Unsaturated	59-82	peroxisome proliferator activated receptor alpha	Mus musculus	118-127
18301758-7	2008	In addition, the majority of genes regulated by unsaturated fatty acids, especially docosahexaenoic acid, were also regulated by the specific PPARalpha agonist WY14643.	Fatty Acids, Unsaturated	48-71	peroxisome proliferator activated receptor alpha	Mus musculus	142-151
18301758-10	2008	CONCLUSIONS/SIGNIFICANCE: We conclude that the effects of dietary unsaturated fatty acids on hepatic gene expression are almost entirely mediated by PPARalpha and mimic those of synthetic PPARalpha agonists in terms of regulation of target genes and molecular mechanism.	Fatty Acids, Unsaturated	66-89	peroxisome proliferator activated receptor alpha	Mus musculus	149-158
18301758-10	2008	CONCLUSIONS/SIGNIFICANCE: We conclude that the effects of dietary unsaturated fatty acids on hepatic gene expression are almost entirely mediated by PPARalpha and mimic those of synthetic PPARalpha agonists in terms of regulation of target genes and molecular mechanism.	Fatty Acids, Unsaturated	66-89	peroxisome proliferator activated receptor alpha	Mus musculus	188-197
18258624-1	2008	BACKGROUND: Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents.	Fatty Acids, Unsaturated	83-88	adiponectin, C1Q and collagen domain containing	Homo sapiens	111-122
17868330-3	2008	n-3 polyunsaturated fatty acids (PUFA), such as those found in fish oil (FO), are naturally occurring PPARalpha ligands which also suppress lipid synthesis.	Fatty Acids, Unsaturated	33-37	peroxisome proliferator activated receptor alpha	Mus musculus	102-111
18077200-4	2008	The long chain polyunsaturated fatty acid (LCPUFA) arachidonic acid (AA, 20:4n-6) and its metabolite prostaglandin E2 (PGE2), are pro-inflammatory and PGE2 is a potent stimulator of RANKL expression.	Fatty Acids, Unsaturated	15-41	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	182-187
18314499-3	2008	Here, we demonstrate that LT-treated vte2 has a distinct composition of polyunsaturated fatty acids (PUFAs): lower levels of linolenic acid (18:3) and higher levels of linoleic acid (18:2) compared with the wild type.	Fatty Acids, Unsaturated	72-99	homogentisate phytyltransferase 1	Arabidopsis thaliana	37-41
18314499-3	2008	Here, we demonstrate that LT-treated vte2 has a distinct composition of polyunsaturated fatty acids (PUFAs): lower levels of linolenic acid (18:3) and higher levels of linoleic acid (18:2) compared with the wild type.	Fatty Acids, Unsaturated	101-106	homogentisate phytyltransferase 1	Arabidopsis thaliana	37-41
17868330-10	2008	CONCLUSIONS: Feeding an n-3 PUFA-enriched diet activated PPARalpha and suppressed hepatic de novo lipogenesis, but failed to prevent development of steatohepatitis in the presence of methionine and choline deficiency.	Fatty Acids, Unsaturated	28-32	peroxisome proliferator activated receptor alpha	Mus musculus	57-66
19039336-5	2008	Rsp5 is also involved in the regulation of unsaturated fatty acid and sterol synthesis and phospholipid composition.	Fatty Acids, Unsaturated	43-65	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	0-4
18067328-1	2008	Lipoxygenase plays a central role in polyunsaturated fatty acid metabolism, inaugurating the biosynthesis of eicosanoids in animals and phytooxylipins in plants.	Fatty Acids, Unsaturated	37-63	linoleate 9S-lipoxygenase-4	Glycine max	0-12
18434716-6	2008	The intake of polyunsaturated fatty acids (PUFAs) was higher, saturated fat and the omega-6 to omega-3 PUFA ratio were in the upper limit, and omega-3 PUFAs (% caloric intake, En) were lower than the recommended dietary allowance for Asian Indians.	Fatty Acids, Unsaturated	14-41	pumilio RNA binding family member 3	Homo sapiens	43-47
17960445-0	2008	Delta6 desaturase mRNA abundance in HepG2 cells is suppressed by unsaturated fatty acids.	Fatty Acids, Unsaturated	65-88	fatty acid desaturase 2	Homo sapiens	0-17
18166358-0	2008	PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism.	Fatty Acids, Unsaturated	24-47	phosphatase and tensin homolog	Homo sapiens	0-4
18166358-0	2008	PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism.	Fatty Acids, Unsaturated	24-47	RELA proto-oncogene, NF-kB subunit	Homo sapiens	82-94
18166358-0	2008	PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism.	Fatty Acids, Unsaturated	24-47	mechanistic target of rapamycin kinase	Homo sapiens	95-99
18166358-7	2008	Unsaturated fatty acids inhibited PTEN expression in HepG2 cells via activation of a signaling complex formed by the mammalian target of rapamycin (mTOR) and nuclear factor-kappaB (NF-kappaB).	Fatty Acids, Unsaturated	0-23	phosphatase and tensin homolog	Homo sapiens	34-38
18166358-7	2008	Unsaturated fatty acids inhibited PTEN expression in HepG2 cells via activation of a signaling complex formed by the mammalian target of rapamycin (mTOR) and nuclear factor-kappaB (NF-kappaB).	Fatty Acids, Unsaturated	0-23	mechanistic target of rapamycin kinase	Homo sapiens	148-152
18166358-9	2008	CONCLUSIONS: Hepatic steatosis can be mediated by alterations of PTEN expression in hepatocytes exposed to high levels of unsaturated fatty acids.	Fatty Acids, Unsaturated	122-145	phosphatase and tensin homolog	Homo sapiens	65-69
19776629-0	2008	Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and plasma high-density lipoprotein-cholesterol concentrations in a population of young adults.	Fatty Acids, Unsaturated	92-119	tumor necrosis factor	Homo sapiens	25-52
19776629-1	2008	BACKGROUND/AIMS: Genetic polymorphisms in tumor necrosis factor-alpha (TNF-alpha) modify the association between polyunsaturated fatty acids (PUFA) and plasma high-density lipoprotein (HDL) cholesterol in a population with type 2 diabetes.	Fatty Acids, Unsaturated	113-140	tumor necrosis factor	Homo sapiens	42-69
19776629-1	2008	BACKGROUND/AIMS: Genetic polymorphisms in tumor necrosis factor-alpha (TNF-alpha) modify the association between polyunsaturated fatty acids (PUFA) and plasma high-density lipoprotein (HDL) cholesterol in a population with type 2 diabetes.	Fatty Acids, Unsaturated	113-140	tumor necrosis factor	Homo sapiens	71-80
19776629-1	2008	BACKGROUND/AIMS: Genetic polymorphisms in tumor necrosis factor-alpha (TNF-alpha) modify the association between polyunsaturated fatty acids (PUFA) and plasma high-density lipoprotein (HDL) cholesterol in a population with type 2 diabetes.	Fatty Acids, Unsaturated	142-146	tumor necrosis factor	Homo sapiens	42-69
19776629-1	2008	BACKGROUND/AIMS: Genetic polymorphisms in tumor necrosis factor-alpha (TNF-alpha) modify the association between polyunsaturated fatty acids (PUFA) and plasma high-density lipoprotein (HDL) cholesterol in a population with type 2 diabetes.	Fatty Acids, Unsaturated	142-146	tumor necrosis factor	Homo sapiens	71-80
17656037-10	2008	Trans fats, partially oxidized PUFA entities, and inappropriate omega-6:omega-3 ratios are all potential sources of unsaturated fatty acids that can disrupt the normal membrane structure.	Fatty Acids, Unsaturated	116-139	pumilio RNA binding family member 3	Homo sapiens	31-35
17960445-1	2008	The effect of unsaturated fatty acids on the abundance of Delta6 desaturase (D6D) mRNA and the fatty acid composition of HepG2 cell membranes was examined.	Fatty Acids, Unsaturated	14-37	fatty acid desaturase 2	Homo sapiens	64-75
17960445-1	2008	The effect of unsaturated fatty acids on the abundance of Delta6 desaturase (D6D) mRNA and the fatty acid composition of HepG2 cell membranes was examined.	Fatty Acids, Unsaturated	14-37	fatty acid desaturase 2	Homo sapiens	77-80
17960445-4	2008	Our results suggest that although unsaturated fatty acids decrease the abundance of D6D mRNA by as much as 50%, the conversion of polyunsaturated fatty acids and accumulation of long chain polyunsaturated fatty acids (LCPUFA) in HepG2 cell phospholipids continues to occur.	Fatty Acids, Unsaturated	34-57	fatty acid desaturase 2	Homo sapiens	84-87
17954559-1	2008	Peroxisome proliferator-activated receptor gamma (PPARgamma) activity is regulated through association with ligands that include the thiazolidinedione class of antidiabetic drugs, as well as derivatives of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	206-233	peroxisome proliferator activated receptor gamma	Homo sapiens	0-48
18998088-2	2008	TREK1 knockout mice display impaired polyunsaturated fatty acid-mediated protection against brain ischemia, reduced sensitivity to volatile anesthetics, resistance to depression and altered perception of pain.	Fatty Acids, Unsaturated	37-63	potassium channel, subfamily K, member 2	Mus musculus	0-5
17954559-1	2008	Peroxisome proliferator-activated receptor gamma (PPARgamma) activity is regulated through association with ligands that include the thiazolidinedione class of antidiabetic drugs, as well as derivatives of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	206-233	peroxisome proliferator activated receptor gamma	Homo sapiens	50-59
18036803-3	2008	CLA and omega-3 long-chain polyunsaturated fatty acids (PUFA) (FA) reduced TNF-alpha-induced expression of ADMs (intercellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1) but not E-selectin) on HUVEC and vSMC to different extents depending on FA type and concentration, cell type and method of analysis.	Fatty Acids, Unsaturated	56-60	tumor necrosis factor	Homo sapiens	75-84
18769551-1	2008	Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural ligands for peroxisome proliferator receptor activator (PPAR)gamma and, due to the effects of PPARgamma on cell proliferation, survival, and differentiation, are potential anticancer agents.	Fatty Acids, Unsaturated	46-51	peroxisome proliferator activated receptor gamma	Homo sapiens	143-153
18769551-1	2008	Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural ligands for peroxisome proliferator receptor activator (PPAR)gamma and, due to the effects of PPARgamma on cell proliferation, survival, and differentiation, are potential anticancer agents.	Fatty Acids, Unsaturated	46-51	peroxisome proliferator activated receptor gamma	Homo sapiens	181-190
18036803-3	2008	CLA and omega-3 long-chain polyunsaturated fatty acids (PUFA) (FA) reduced TNF-alpha-induced expression of ADMs (intercellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1) but not E-selectin) on HUVEC and vSMC to different extents depending on FA type and concentration, cell type and method of analysis.	Fatty Acids, Unsaturated	56-60	intercellular adhesion molecule 1	Homo sapiens	113-146
18036803-3	2008	CLA and omega-3 long-chain polyunsaturated fatty acids (PUFA) (FA) reduced TNF-alpha-induced expression of ADMs (intercellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1) but not E-selectin) on HUVEC and vSMC to different extents depending on FA type and concentration, cell type and method of analysis.	Fatty Acids, Unsaturated	56-60	intercellular adhesion molecule 1	Homo sapiens	148-154
18036803-3	2008	CLA and omega-3 long-chain polyunsaturated fatty acids (PUFA) (FA) reduced TNF-alpha-induced expression of ADMs (intercellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1) but not E-selectin) on HUVEC and vSMC to different extents depending on FA type and concentration, cell type and method of analysis.	Fatty Acids, Unsaturated	56-60	vascular cell adhesion molecule 1	Homo sapiens	157-190
18036803-3	2008	CLA and omega-3 long-chain polyunsaturated fatty acids (PUFA) (FA) reduced TNF-alpha-induced expression of ADMs (intercellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1) but not E-selectin) on HUVEC and vSMC to different extents depending on FA type and concentration, cell type and method of analysis.	Fatty Acids, Unsaturated	56-60	vascular cell adhesion molecule 1	Homo sapiens	192-198
18036803-3	2008	CLA and omega-3 long-chain polyunsaturated fatty acids (PUFA) (FA) reduced TNF-alpha-induced expression of ADMs (intercellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1) but not E-selectin) on HUVEC and vSMC to different extents depending on FA type and concentration, cell type and method of analysis.	Fatty Acids, Unsaturated	56-60	selectin E	Homo sapiens	208-218
18032786-0	2007	The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR.	Fatty Acids, Unsaturated	64-90	tumor protein p53	Homo sapiens	127-130
17904175-3	2007	Our previous study showed that PB-induced CYP 2B1 expression in rat primary hepatocytes is down-regulated by both n-6 and n-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid (DHA); however, the mechanism for this down-regulation by DHA was previously unknown.	Fatty Acids, Unsaturated	155-160	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	42-49
17584839-3	2007	Polyunsaturated fatty acids (PUFAs) have been proposed to have a number of multiple effectors, including ion channels and the cytoskeleton, but the precise mechanism of PUFA action is still unclear.	Fatty Acids, Unsaturated	0-27	pumilio RNA binding family member 3	Homo sapiens	29-33
18055555-0	2007	Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells.	Fatty Acids, Unsaturated	0-27	synuclein alpha	Homo sapiens	35-50
17898990-1	2007	AIMS/HYPOTHESIS: Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner.	Fatty Acids, Unsaturated	167-194	peroxisome proliferator activated receptor gamma	Homo sapiens	17-65
17898990-1	2007	AIMS/HYPOTHESIS: Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner.	Fatty Acids, Unsaturated	167-194	peroxisome proliferator activated receptor gamma	Homo sapiens	67-76
17898990-1	2007	AIMS/HYPOTHESIS: Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner.	Fatty Acids, Unsaturated	167-194	peroxisome proliferator activated receptor gamma	Homo sapiens	94-99
17898990-1	2007	AIMS/HYPOTHESIS: Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner.	Fatty Acids, Unsaturated	196-200	peroxisome proliferator activated receptor gamma	Homo sapiens	17-65
17898990-1	2007	AIMS/HYPOTHESIS: Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner.	Fatty Acids, Unsaturated	196-200	peroxisome proliferator activated receptor gamma	Homo sapiens	67-76
17898990-1	2007	AIMS/HYPOTHESIS: Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner.	Fatty Acids, Unsaturated	196-200	peroxisome proliferator activated receptor gamma	Homo sapiens	94-99
18290715-10	2007	VDR also selectively binds certain omega3/omega6 polyunsaturated fatty acids (PUFAs) with low affinity, leading to transcriptionally active VDR-RXR complexes.	Fatty Acids, Unsaturated	78-83	vitamin D receptor	Homo sapiens	0-3
18290715-10	2007	VDR also selectively binds certain omega3/omega6 polyunsaturated fatty acids (PUFAs) with low affinity, leading to transcriptionally active VDR-RXR complexes.	Fatty Acids, Unsaturated	78-83	vitamin D receptor	Homo sapiens	140-143
18290715-10	2007	VDR also selectively binds certain omega3/omega6 polyunsaturated fatty acids (PUFAs) with low affinity, leading to transcriptionally active VDR-RXR complexes.	Fatty Acids, Unsaturated	78-83	retinoid X receptor alpha	Homo sapiens	144-147
18290715-12	2007	Activation of VDR by PUFAs and curcumin may elicit unique, 1,25(OH)(2)D(3)-independent signaling pathways to orchestrate the bioeffects of these lipids in intestine, bone, skin/hair follicle, and other VDR-containing tissues.	Fatty Acids, Unsaturated	21-26	vitamin D receptor	Homo sapiens	14-17
18290715-12	2007	Activation of VDR by PUFAs and curcumin may elicit unique, 1,25(OH)(2)D(3)-independent signaling pathways to orchestrate the bioeffects of these lipids in intestine, bone, skin/hair follicle, and other VDR-containing tissues.	Fatty Acids, Unsaturated	21-26	vitamin D receptor	Homo sapiens	202-205
18032786-10	2007	Our findings establish that cells can regulate the levels of polyunsaturated fatty acids in phospholipids through iPLA(2)-mediated deacylation of PCs.	Fatty Acids, Unsaturated	61-88	phospholipase A2 group VI	Homo sapiens	114-121
18032786-11	2007	Disruption of this regulation increases the proportions of PCs containing polyunsaturated fatty acids and activates the ATR-p53 signalling pathway.	Fatty Acids, Unsaturated	74-101	tumor protein p53	Homo sapiens	124-127
18032786-0	2007	The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR.	Fatty Acids, Unsaturated	64-90	ATR serine/threonine kinase	Homo sapiens	153-156
18032786-8	2007	The time course of phosphorylation of Ser15 in p53 correlates with increasing levels of PCs containing polyunsaturated fatty acids.	Fatty Acids, Unsaturated	103-130	tumor protein p53	Homo sapiens	47-50
17624613-0	2007	Inhibitory effect of polyunsaturated fatty acids on MMP-9 release from microglial cells--implications for complementary multiple sclerosis treatment.	Fatty Acids, Unsaturated	21-48	matrix metallopeptidase 9	Homo sapiens	52-57
17624613-1	2007	We investigated whether polyunsaturated fatty acids (PUFA), which might be a useful complementary therapy among patients with multiple sclerosis (MS), are able to modulate matrix metalloproteinase (MMP) production in microglial cultures.	Fatty Acids, Unsaturated	24-51	matrix metallopeptidase 2	Homo sapiens	198-201
17624613-1	2007	We investigated whether polyunsaturated fatty acids (PUFA), which might be a useful complementary therapy among patients with multiple sclerosis (MS), are able to modulate matrix metalloproteinase (MMP) production in microglial cultures.	Fatty Acids, Unsaturated	53-57	matrix metallopeptidase 2	Homo sapiens	198-201
18060754-8	2007	These changes, plus reduced levels of brain derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) in n-3 PUFA diet deficient rats, likely render their brain more vulnerable to neuropathological insults.	Fatty Acids, Unsaturated	135-139	cAMP responsive element binding protein 1	Rattus norvegicus	83-120
16996649-5	2007	The activity of PEMT in the liver plays an important role in the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) and the delivery of essential polyunsaturated fatty acids (PUFAs) to peripheral tissues.	Fatty Acids, Unsaturated	168-195	phosphatidylethanolamine N-methyltransferase	Homo sapiens	16-20
16996649-5	2007	The activity of PEMT in the liver plays an important role in the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) and the delivery of essential polyunsaturated fatty acids (PUFAs) to peripheral tissues.	Fatty Acids, Unsaturated	197-202	phosphatidylethanolamine N-methyltransferase	Homo sapiens	16-20
17785633-3	2007	Endogenous or pharmacological PPARgamma agonists (unsaturated fatty acids and thiazolidinediones, respectively) stimulated renin gene expression.	Fatty Acids, Unsaturated	50-73	peroxisome proliferator activated receptor gamma	Homo sapiens	30-39
17785633-3	2007	Endogenous or pharmacological PPARgamma agonists (unsaturated fatty acids and thiazolidinediones, respectively) stimulated renin gene expression.	Fatty Acids, Unsaturated	50-73	renin	Homo sapiens	123-128
18060754-8	2007	These changes, plus reduced levels of brain derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) in n-3 PUFA diet deficient rats, likely render their brain more vulnerable to neuropathological insults.	Fatty Acids, Unsaturated	135-139	cAMP responsive element binding protein 1	Rattus norvegicus	122-126
17516915-4	2007	PTGS2 protein level was increased by PPAR agonists, including polyunsaturated fatty acids, synthetic PPAR ligands, PGA1 and NSAIDs (non-steroidal anti-inflammatory drugs) with a time course resembling that of arachidonic acid.	Fatty Acids, Unsaturated	62-89	prostaglandin-endoperoxide synthase 2	Bos taurus	0-5
17892360-4	2007	Second, Lp-PLA2 hydrolyzes oxidatively modified polyunsaturated fatty acids producing lysophosphatidylcholine (LysoPC) and oxidized nonesterified fatty acids (OxNEFA).	Fatty Acids, Unsaturated	48-75	phospholipase A2 group VII	Homo sapiens	8-15
17472580-0	2007	Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblasts.	Fatty Acids, Unsaturated	0-27	NADPH oxidase 4	Homo sapiens	37-42
17532154-2	2007	Polyunsaturated fatty acids of the n-3 series (n-3 PUFA) are known to play a role in the prevention of the inflammatory response.	Fatty Acids, Unsaturated	0-27	pumilio RNA binding family member 3	Homo sapiens	51-55
18079609-5	2007	UCP-2 mRNA expression was more markedly increased by glucose, unsaturated fatty acids, insulin and T3 than UCP-1 or -3 mRNA expression.	Fatty Acids, Unsaturated	62-85	uncoupling protein 2	Rattus norvegicus	0-5
17823444-0	2007	Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo A-I concentrations.	Fatty Acids, Unsaturated	92-119	tumor necrosis factor	Homo sapiens	25-52
17823444-0	2007	Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo A-I concentrations.	Fatty Acids, Unsaturated	92-119	apolipoprotein A1	Homo sapiens	152-159
17472580-4	2007	Furthermore, we show that, in cell lysates, NOX 4 activity can be modulated by PUFAs (polyunsaturated fatty acids) at the micromolar level in the presence of calcium: NOX 4 activity is increased by arachidonic acid (C20:4,n-6) (approximately 175% of the control), and conjugated linoleic acid (C18:2 [9Z,11E]) is a potent inhibitor (50% of the control).	Fatty Acids, Unsaturated	79-84	NADPH oxidase 4	Homo sapiens	44-49
17472580-4	2007	Furthermore, we show that, in cell lysates, NOX 4 activity can be modulated by PUFAs (polyunsaturated fatty acids) at the micromolar level in the presence of calcium: NOX 4 activity is increased by arachidonic acid (C20:4,n-6) (approximately 175% of the control), and conjugated linoleic acid (C18:2 [9Z,11E]) is a potent inhibitor (50% of the control).	Fatty Acids, Unsaturated	79-84	NADPH oxidase 4	Homo sapiens	167-172
17472580-4	2007	Furthermore, we show that, in cell lysates, NOX 4 activity can be modulated by PUFAs (polyunsaturated fatty acids) at the micromolar level in the presence of calcium: NOX 4 activity is increased by arachidonic acid (C20:4,n-6) (approximately 175% of the control), and conjugated linoleic acid (C18:2 [9Z,11E]) is a potent inhibitor (50% of the control).	Fatty Acids, Unsaturated	86-113	NADPH oxidase 4	Homo sapiens	44-49
17472580-4	2007	Furthermore, we show that, in cell lysates, NOX 4 activity can be modulated by PUFAs (polyunsaturated fatty acids) at the micromolar level in the presence of calcium: NOX 4 activity is increased by arachidonic acid (C20:4,n-6) (approximately 175% of the control), and conjugated linoleic acid (C18:2 [9Z,11E]) is a potent inhibitor (50% of the control).	Fatty Acids, Unsaturated	86-113	NADPH oxidase 4	Homo sapiens	167-172
17666827-1	2007	This study was conducted to investigate the inhibitory effects of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) on cytochrome P450 3A (CYP3A).	Fatty Acids, Unsaturated	137-164	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	176-194
17666827-1	2007	This study was conducted to investigate the inhibitory effects of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) on cytochrome P450 3A (CYP3A).	Fatty Acids, Unsaturated	137-164	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	196-201
17666827-4	2007	Among the four PUFAs examined (linoleic acid, gamma-linolenic acid, retinoic acid, and docosahexaenoic acid; DHA), the highest inhibitory effect of CYP3A-catalyzed testosterone metabolism was observed with DHA, which inhibited testosterone metabolism by 94%.	Fatty Acids, Unsaturated	15-20	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	148-153
17634253-0	2007	Interleukin1beta genetic polymorphisms interact with polyunsaturated fatty acids to modulate risk of the metabolic syndrome.	Fatty Acids, Unsaturated	53-80	interleukin 1 beta	Homo sapiens	0-16
17878672-2	2007	Exact relationship between saturated fatty acids (SFA) or PUFA and the insulin resistance of diabetics are unknown.	Fatty Acids, Unsaturated	58-62	insulin	Homo sapiens	71-78
17556656-0	2007	Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel.	Fatty Acids, Unsaturated	0-27	potassium channel, subfamily K, member 2	Mus musculus	62-68
17556656-6	2007	This suggested that the target of the polyunsaturated fatty acids effect was the TREK-1 potassium channel.	Fatty Acids, Unsaturated	38-65	potassium channel, subfamily K, member 2	Mus musculus	81-87
17556656-10	2007	They suggest that the selective expression and activation of TREK-1 in brain collaterals could play a significant role in the protective mechanisms of polyunsaturated fatty acids against stroke by providing residual circulation during ischemia.	Fatty Acids, Unsaturated	151-178	potassium channel, subfamily K, member 2	Mus musculus	61-67
17556656-8	2007	We show that vasodilations induced by the polyunsaturated fatty acid in the basilar artery as well as the laser-Doppler flow increase are abolished in TREK-1(-/-) mice.	Fatty Acids, Unsaturated	42-68	potassium channel, subfamily K, member 2	Mus musculus	151-157
17556656-9	2007	Altogether these data indicate that TREK-1 activation elicits a robust dilation that probably accounts for the increase of cerebral blood flow induced by polyunsaturated fatty acids such as alpha-linolenic acid or docosahexanoic acid.	Fatty Acids, Unsaturated	154-181	potassium channel, subfamily K, member 2	Mus musculus	36-42
22444754-1	2007	Supplementation of pregnant ewes with long-chain n-3 polyunsaturated fatty acids (PUFA) demonstrably improves indicators of neonatal lamb vigour, potentially improving the number of lambs reared per ewe.	Fatty Acids, Unsaturated	82-86	PUFA	Ovis aries	53-80
17510185-1	2007	During cardiac ischaemia antiarrhythmic n-3 polyunsaturated fatty acids (PUFAs) are released following activation of phospholipase A2, if they are in the diet prior to ischaemia.	Fatty Acids, Unsaturated	73-78	phospholipase A2 group IB	Rattus norvegicus	117-133
17547694-5	2007	Alternation of the n-6/n-3 ratio in favor of n-3 PUFA, and particularly docosapentaenoic acid, in the mammary gland of fat-1 mouse resulted in development of lobulo-alveolar-like structure and milk protein beta-casein expression, mimicking the differentiated state of the pregnant gland.	Fatty Acids, Unsaturated	49-53	FAT atypical cadherin 1	Mus musculus	119-124
17659475-4	2007	In addition, all members of the TREK familyare activated by neuroprotective agents, such as riluzole, polyunsaturated fatty acids and lysophospholipids, suggesting that these channels play an important role in neuroprotection.	Fatty Acids, Unsaturated	102-129	potassium two pore domain channel subfamily K member 2	Homo sapiens	32-36
17624748-6	2007	Suppression of COX-2 resulted in increased concentration of most of polyunsaturated fatty acids especially arachidonic acid (AA).	Fatty Acids, Unsaturated	68-95	prostaglandin-endoperoxide synthase 2	Mus musculus	15-20
17565616-4	2007	The PLDalpha1-deficient seeds exhibited a smaller loss of unsaturated fatty acids and lower accumulation of lipid peroxides than did wild-type seeds.	Fatty Acids, Unsaturated	58-81	phospholipase D alpha 1	Arabidopsis thaliana	4-13
17435249-7	2007	The strain with the most severe defect in the production of unsaturated fatty acids, fat-6;fat-7, exhibits slow growth and reduced fertility.	Fatty Acids, Unsaturated	60-83	Delta(9)-fatty-acid desaturase fat-6	Caenorhabditis elegans	85-90
17435249-7	2007	The strain with the most severe defect in the production of unsaturated fatty acids, fat-6;fat-7, exhibits slow growth and reduced fertility.	Fatty Acids, Unsaturated	60-83	Delta(9)-fatty-acid desaturase fat-7	Caenorhabditis elegans	91-96
17507388-2	2007	At 22 degrees C, fad2 mitochondria exhibited a low polyunsaturated fatty acid content and low protein to lipid ratio, while mitochondria from FAD3+ were enriched in linolenic acid and in total membrane protein.	Fatty Acids, Unsaturated	51-77	fatty acid desaturase 2	Arabidopsis thaliana	17-21
17325386-4	2007	We previously reported that unsaturated fatty acids destabilize ABCA1 in murine macrophages and ABCA1-transfected baby hamster kidney cells by increasing its serine phosphorylation through a phospholipase D (PLD) pathway.	Fatty Acids, Unsaturated	28-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	208-211
17325386-5	2007	Here, we examined the cellular pathway downstream of PLD that mediates the ABCA1-destabilizing effects of unsaturated fatty acids.	Fatty Acids, Unsaturated	106-129	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-56
17325386-0	2007	Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathway.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	54-59
17325386-5	2007	Here, we examined the cellular pathway downstream of PLD that mediates the ABCA1-destabilizing effects of unsaturated fatty acids.	Fatty Acids, Unsaturated	106-129	ATP binding cassette subfamily A member 1	Homo sapiens	75-80
17325386-0	2007	Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathway.	Fatty Acids, Unsaturated	0-23	protein kinase C delta	Homo sapiens	70-92
17325386-3	2007	Unsaturated fatty acids, which are increased in diabetes, impair the ABCA1 pathway in cultured cells by destabilizing ABCA1 protein.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	69-74
17325386-3	2007	Unsaturated fatty acids, which are increased in diabetes, impair the ABCA1 pathway in cultured cells by destabilizing ABCA1 protein.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	118-123
17325386-4	2007	We previously reported that unsaturated fatty acids destabilize ABCA1 in murine macrophages and ABCA1-transfected baby hamster kidney cells by increasing its serine phosphorylation through a phospholipase D (PLD) pathway.	Fatty Acids, Unsaturated	28-51	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	64-69
17325386-6	2007	The protein kinase C delta (PKCdelta)-specific inhibitor rottlerin and PKCdelta small interfering RNA completely abolished the ability of unsaturated fatty acids to inhibit lipid transport activity, to reduce protein levels, and to increase serine phosphorylation of ABCA1, implicating a role for PKCdelta in the ABCA1-destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	138-161	protein kinase C delta	Homo sapiens	4-26
17425611-7	2007	By contrast, feeding with both high-PUFA diets increased POMC and GALP mRNA expression in the ARC compared to the corresponding low-fat diet and the high-saturated fat diet.	Fatty Acids, Unsaturated	36-40	proopiomelanocortin	Rattus norvegicus	57-61
17325386-6	2007	The protein kinase C delta (PKCdelta)-specific inhibitor rottlerin and PKCdelta small interfering RNA completely abolished the ability of unsaturated fatty acids to inhibit lipid transport activity, to reduce protein levels, and to increase serine phosphorylation of ABCA1, implicating a role for PKCdelta in the ABCA1-destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	138-161	protein kinase C delta	Homo sapiens	28-36
17425611-7	2007	By contrast, feeding with both high-PUFA diets increased POMC and GALP mRNA expression in the ARC compared to the corresponding low-fat diet and the high-saturated fat diet.	Fatty Acids, Unsaturated	36-40	galanin-like peptide	Rattus norvegicus	66-70
17325386-6	2007	The protein kinase C delta (PKCdelta)-specific inhibitor rottlerin and PKCdelta small interfering RNA completely abolished the ability of unsaturated fatty acids to inhibit lipid transport activity, to reduce protein levels, and to increase serine phosphorylation of ABCA1, implicating a role for PKCdelta in the ABCA1-destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	138-161	protein kinase C delta	Homo sapiens	71-79
17425611-8	2007	Furthermore, feeding with both low-PUFA diets reduced NPY mRNA expression compared to the low-saturated fat diet exclusively in the DMHc.	Fatty Acids, Unsaturated	35-39	neuropeptide Y	Rattus norvegicus	54-57
17325386-6	2007	The protein kinase C delta (PKCdelta)-specific inhibitor rottlerin and PKCdelta small interfering RNA completely abolished the ability of unsaturated fatty acids to inhibit lipid transport activity, to reduce protein levels, and to increase serine phosphorylation of ABCA1, implicating a role for PKCdelta in the ABCA1-destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	138-161	ATP binding cassette subfamily A member 1	Homo sapiens	267-272
17325386-6	2007	The protein kinase C delta (PKCdelta)-specific inhibitor rottlerin and PKCdelta small interfering RNA completely abolished the ability of unsaturated fatty acids to inhibit lipid transport activity, to reduce protein levels, and to increase serine phosphorylation of ABCA1, implicating a role for PKCdelta in the ABCA1-destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	138-161	protein kinase C delta	Homo sapiens	71-79
17325386-6	2007	The protein kinase C delta (PKCdelta)-specific inhibitor rottlerin and PKCdelta small interfering RNA completely abolished the ability of unsaturated fatty acids to inhibit lipid transport activity, to reduce protein levels, and to increase serine phosphorylation of ABCA1, implicating a role for PKCdelta in the ABCA1-destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	138-161	ATP binding cassette subfamily A member 1	Homo sapiens	313-318
17325386-7	2007	These data indicate that unsaturated fatty acids destabilize ABCA1 by activating a PKCdelta pathway that phosphorylates ABCA1 serines.	Fatty Acids, Unsaturated	25-48	ATP binding cassette subfamily A member 1	Homo sapiens	61-66
17325386-7	2007	These data indicate that unsaturated fatty acids destabilize ABCA1 by activating a PKCdelta pathway that phosphorylates ABCA1 serines.	Fatty Acids, Unsaturated	25-48	protein kinase C delta	Homo sapiens	83-91
17325386-7	2007	These data indicate that unsaturated fatty acids destabilize ABCA1 by activating a PKCdelta pathway that phosphorylates ABCA1 serines.	Fatty Acids, Unsaturated	25-48	ATP binding cassette subfamily A member 1	Homo sapiens	120-125
17052999-1	2007	N-3 polyunsaturated fatty acids (PUFA) and genistein have been associated with lowered cancer risk by reducing inflammatory prostanoids, cyclooxygenase-2 (COX-2) activity, and altering cell signaling.	Fatty Acids, Unsaturated	33-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	137-153
17303577-8	2007	In contrast, polyunsaturated fatty acids, especially n-3 polyunsaturated fatty acids, inhibited the activation of NF-kappaB and IL-8 expression induced by lauric acid or known Nods ligands in HCT116.	Fatty Acids, Unsaturated	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17355126-1	2007	The mechanism by which cyclooxygenase-1 (COX-1), a heme- and tyrosyl radical-containing enzyme, catalyzes the regio- and stereospecific oxygenation of polyunsaturated fatty acids to prostaglandin or hydroperoxide products has not been understood.	Fatty Acids, Unsaturated	151-178	prostaglandin-endoperoxide synthase 1	Homo sapiens	23-39
17355126-1	2007	The mechanism by which cyclooxygenase-1 (COX-1), a heme- and tyrosyl radical-containing enzyme, catalyzes the regio- and stereospecific oxygenation of polyunsaturated fatty acids to prostaglandin or hydroperoxide products has not been understood.	Fatty Acids, Unsaturated	151-178	prostaglandin-endoperoxide synthase 1	Homo sapiens	41-46
17052999-1	2007	N-3 polyunsaturated fatty acids (PUFA) and genistein have been associated with lowered cancer risk by reducing inflammatory prostanoids, cyclooxygenase-2 (COX-2) activity, and altering cell signaling.	Fatty Acids, Unsaturated	33-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	155-160
17120019-3	2007	We therefore investigated the effects of polyunsaturated fatty acids on hEAG1 channels.	Fatty Acids, Unsaturated	41-68	potassium voltage-gated channel subfamily H member 1	Homo sapiens	72-77
17393226-6	2007	Moreover, this demonstrates the existence of an interaction between unsaturated fatty acids and cholesterol metabolism performed by the insulin/SREBP-1c system and LXR/RXR.	Fatty Acids, Unsaturated	68-91	sterol regulatory element binding transcription factor 1	Rattus norvegicus	144-152
17393230-7	2007	The decreased levels in polyunsaturated fatty acids in PC together with a pronounced increase in C18:1omega9 and C18:2omega6 were indicative of an impaired delta-6 desaturase.	Fatty Acids, Unsaturated	24-51	fatty acid desaturase 2	Rattus norvegicus	156-174
17375039-3	2007	Moreover, K(2P) channels are modulated by a variety of cellular lipids and pharmacological agents, including polyunsaturated fatty acids and volatile general anaesthetics.	Fatty Acids, Unsaturated	109-136	keratin 76	Homo sapiens	10-15
17515866-4	2007	PUFA supplementation reduced the incidence of NEC and inhibited intestinal PAFR and TLR4 gene expression compared with the controls.	Fatty Acids, Unsaturated	0-4	platelet-activating factor receptor	Rattus norvegicus	75-79
17515866-4	2007	PUFA supplementation reduced the incidence of NEC and inhibited intestinal PAFR and TLR4 gene expression compared with the controls.	Fatty Acids, Unsaturated	0-4	toll-like receptor 4	Rattus norvegicus	84-88
17313375-0	2007	Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c.	Fatty Acids, Unsaturated	0-26	fatty acid synthase	Homo sapiens	42-61
17313375-0	2007	Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c.	Fatty Acids, Unsaturated	0-26	fatty acid synthase	Homo sapiens	63-67
17313375-0	2007	Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c.	Fatty Acids, Unsaturated	0-26	fatty acid synthase	Homo sapiens	125-129
17313375-0	2007	Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c.	Fatty Acids, Unsaturated	0-26	sterol regulatory element binding transcription factor 1	Homo sapiens	142-150
17197450-0	2007	Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate.	Fatty Acids, Unsaturated	94-120	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	81-86
16730733-0	2007	Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily G member 1	Homo sapiens	55-90
16730733-0	2007	Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily G member 1	Homo sapiens	92-97
16730733-0	2007	Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	103-108
16730733-0	2007	Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element.	Fatty Acids, Unsaturated	0-23	retinoid X receptor alpha	Homo sapiens	126-129
16730733-2	2007	We previously demonstrated that unsaturated fatty acids suppress the stimulatory effects of oxysterols and retinoids on ABCA1 gene transcription.	Fatty Acids, Unsaturated	32-55	ATP binding cassette subfamily A member 1	Homo sapiens	120-125
16730733-3	2007	We here demonstrate that unsaturated fatty acids significantly suppress the stimulatory effects of oxysterols and retinoids on the expression of ABCG1 mRNA and protein and the activity of the wild-type human ABCG1 promoter as well as ABCA1.	Fatty Acids, Unsaturated	25-48	ATP binding cassette subfamily G member 1	Homo sapiens	145-150
16730733-3	2007	We here demonstrate that unsaturated fatty acids significantly suppress the stimulatory effects of oxysterols and retinoids on the expression of ABCG1 mRNA and protein and the activity of the wild-type human ABCG1 promoter as well as ABCA1.	Fatty Acids, Unsaturated	25-48	ATP binding cassette subfamily G member 1	Homo sapiens	208-213
16730733-4	2007	Mutation or deletion of the DR4 element within the ABCG1 or ABCA1 promoters, to which the transcriptional inducers LXR and RXR bind, abolished the suppressive effects of unsaturated fatty acids.	Fatty Acids, Unsaturated	170-193	major histocompatibility complex, class II, DR beta 4	Homo sapiens	28-31
16730733-4	2007	Mutation or deletion of the DR4 element within the ABCG1 or ABCA1 promoters, to which the transcriptional inducers LXR and RXR bind, abolished the suppressive effects of unsaturated fatty acids.	Fatty Acids, Unsaturated	170-193	ATP binding cassette subfamily G member 1	Homo sapiens	51-56
16730733-4	2007	Mutation or deletion of the DR4 element within the ABCG1 or ABCA1 promoters, to which the transcriptional inducers LXR and RXR bind, abolished the suppressive effects of unsaturated fatty acids.	Fatty Acids, Unsaturated	170-193	ATP binding cassette subfamily A member 1	Homo sapiens	60-65
16730733-4	2007	Mutation or deletion of the DR4 element within the ABCG1 or ABCA1 promoters, to which the transcriptional inducers LXR and RXR bind, abolished the suppressive effects of unsaturated fatty acids.	Fatty Acids, Unsaturated	170-193	retinoid X receptor alpha	Homo sapiens	123-126
16730733-5	2007	Our observations provide the first evidence that unsaturated fatty acids suppress ABCG1 gene expression by a mechanism which involves the binding of LXR/RXR to the promoters.	Fatty Acids, Unsaturated	49-72	ATP binding cassette subfamily G member 1	Homo sapiens	82-87
16730733-5	2007	Our observations provide the first evidence that unsaturated fatty acids suppress ABCG1 gene expression by a mechanism which involves the binding of LXR/RXR to the promoters.	Fatty Acids, Unsaturated	49-72	retinoid X receptor alpha	Homo sapiens	153-156
16730733-6	2007	Suppression of both the ABCA1 and ABCG1 genes may indicate that unsaturated fatty acids suppress not only cholesterol efflux to apoA-I and thereby nascent HDL formation but also HDL-dependent cholesterol efflux from vascular cells.	Fatty Acids, Unsaturated	64-87	ATP binding cassette subfamily A member 1	Homo sapiens	24-29
16730733-6	2007	Suppression of both the ABCA1 and ABCG1 genes may indicate that unsaturated fatty acids suppress not only cholesterol efflux to apoA-I and thereby nascent HDL formation but also HDL-dependent cholesterol efflux from vascular cells.	Fatty Acids, Unsaturated	64-87	ATP binding cassette subfamily G member 1	Homo sapiens	34-39
16730733-6	2007	Suppression of both the ABCA1 and ABCG1 genes may indicate that unsaturated fatty acids suppress not only cholesterol efflux to apoA-I and thereby nascent HDL formation but also HDL-dependent cholesterol efflux from vascular cells.	Fatty Acids, Unsaturated	64-87	apolipoprotein A1	Homo sapiens	128-134
22063798-3	2007	Whilst, total polyunsaturated fatty acid (PUFA) reduced with irradiation, which resulted in PUFA to SFA ratio decreased in TL (0 day or 10 days).	Fatty Acids, Unsaturated	42-46	PUFA	Bos taurus	14-40
17242157-0	2007	Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers.	Fatty Acids, Unsaturated	0-27	uncoupling protein 1	Homo sapiens	43-70
17242157-9	2007	The higher uncoupling protein (UCP)-dependent conductance in the presence of polyunsaturated FA is explained on the basis of the FA cycling hypothesis.	Fatty Acids, Unsaturated	77-95	uncoupling protein 1	Homo sapiens	31-34
17196670-0	2007	Does the vagus nerve mediate the effects of polyunsaturated fatty acid treatment on behavioral, neuroendocrine and cytokine changes elicited by exogenous interleukin-1beta challenge?	Fatty Acids, Unsaturated	44-70	interleukin 1 beta	Homo sapiens	154-171
17448756-6	2007	Polyunsaturated fatty acids induced significant activation of upstream caspases 8 and 9 as well as caspase 3.	Fatty Acids, Unsaturated	0-27	caspase 8	Homo sapiens	71-87
17448756-6	2007	Polyunsaturated fatty acids induced significant activation of upstream caspases 8 and 9 as well as caspase 3.	Fatty Acids, Unsaturated	0-27	caspase 3	Homo sapiens	99-108
17376995-0	2007	Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	72-99	transient receptor potential cation channel subfamily M member 8	Cricetulus griseus	41-46
17376995-6	2007	Polyunsaturated fatty acids (PUFAs), such as arachidonic acid, inhibited the activation of TRPM8 by cold, icilin, and menthol.	Fatty Acids, Unsaturated	0-27	transient receptor potential cation channel subfamily M member 8	Cricetulus griseus	91-96
17376995-6	2007	Polyunsaturated fatty acids (PUFAs), such as arachidonic acid, inhibited the activation of TRPM8 by cold, icilin, and menthol.	Fatty Acids, Unsaturated	29-34	transient receptor potential cation channel subfamily M member 8	Cricetulus griseus	91-96
17222806-3	2007	TREK and TRAAK channels are two P domain background potassium channels activated by polyunsaturated fatty acids and mechanical stress.	Fatty Acids, Unsaturated	84-111	potassium channel, subfamily K, member 4	Mus musculus	9-14
17328054-2	2007	Modulation of TNF receptors (TNFRs) may contribute to the regulation of tissue damage, and n-6 polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA) can increase the expression of TNFRI and TNFRII on neutrophils.	Fatty Acids, Unsaturated	124-129	TNF receptor superfamily member 1A	Homo sapiens	192-197
17328054-2	2007	Modulation of TNF receptors (TNFRs) may contribute to the regulation of tissue damage, and n-6 polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA) can increase the expression of TNFRI and TNFRII on neutrophils.	Fatty Acids, Unsaturated	124-129	TNF receptor superfamily member 1B	Homo sapiens	202-208
17189262-2	2007	alpha-Synuclein has been shown to have affinity for unsaturated fatty acids and membranes enriched in polyunsaturated fatty acids, which are especially sensitive to oxidation under conditions of oxidative stress.	Fatty Acids, Unsaturated	52-75	synuclein alpha	Homo sapiens	0-15
17189262-2	2007	alpha-Synuclein has been shown to have affinity for unsaturated fatty acids and membranes enriched in polyunsaturated fatty acids, which are especially sensitive to oxidation under conditions of oxidative stress.	Fatty Acids, Unsaturated	102-129	synuclein alpha	Homo sapiens	0-15
16466902-4	2007	However, much structural divergence in peptide length and fatty acid modification was observed in feline ghrelin: peptides consisting of 27 or 26 amino acids lacking Gln14 and/or Arg28 were found, and the third serine residue was modified by octanoic acid (C8:0), decanoic acid (10:0), or unsaturated fatty acids (C8:1, C10:1 and C10:2).	Fatty Acids, Unsaturated	289-312	ghrelin and obestatin prepropeptide	Rattus norvegicus	105-112
17284757-1	2007	BACKGROUND: Delta(6)-Desaturase (FADS2) is the rate-limiting step in the polyunsaturated fatty acid (PUFA) biosynthetic pathway.	Fatty Acids, Unsaturated	73-99	fatty acid desaturase 2	Homo sapiens	12-31
17284757-1	2007	BACKGROUND: Delta(6)-Desaturase (FADS2) is the rate-limiting step in the polyunsaturated fatty acid (PUFA) biosynthetic pathway.	Fatty Acids, Unsaturated	73-99	fatty acid desaturase 2	Homo sapiens	33-38
17284757-2	2007	OBJECTIVE: The aim was to test whether the common deletion [T/-] in the promoter of FADS2 affects the PUFA biosynthetic pathway and consequently modifies the effect of alpha-linolenic acid (ALA) on myocardial infarction (MI).	Fatty Acids, Unsaturated	102-106	fatty acid desaturase 2	Homo sapiens	84-89
17178388-0	2007	Effects of polyunsaturated fatty acids on calcium response and degranulation from RBL-2H3 cells.	Fatty Acids, Unsaturated	11-38	RB transcriptional corepressor like 2	Rattus norvegicus	82-87
17110164-1	2007	Although each of the five mammalian long-chain acyl-CoA synthetases (ACSL) can bind saturated and unsaturated fatty acids ranging from 12 to 22 carbons, ACSL4 prefers longer chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	180-207	acyl-CoA synthetase long chain family member 4	Homo sapiens	153-158
17234505-6	2007	Total polyunsaturated fatty acid contents in high-density lipoprotein phospholipids increased during LCT infusion (from 29.8 +/- 0.9 to 35.9 +/- 1.4% wt/wt, P &lt; 0.05) and MCT/LCT infusion (from 30.4 +/- 1.0 to 33.0 +/- 0.7%, P &lt; 0.05).	Fatty Acids, Unsaturated	6-32	lactase	Homo sapiens	101-104
18156097-6	2007	In the Framingham Heart Study, complex interactions have been shown between a promoter polymorphism at the apolipoprotein A1 gene, gender, and dietary poly-unsaturated fatty acid intake that modulate plasma concentrations of high-density lipoprotein cholesterol.	Fatty Acids, Unsaturated	151-178	apolipoprotein A1	Homo sapiens	107-124
18220787-1	2007	Cyclooxygenases (COXs), the enzymes involved in the formation of prostaglandins from polyunsaturated fatty acids such as arachidonic acid, exist in two forms--the constitutive COX-1 that is cytoprotective and responsible for the production of prostaglandins and COX-2 which is induced by cytokines, mitogens and endotoxins in inflammatory cells and responsible for the increased levels of prostaglandins during inflammation.	Fatty Acids, Unsaturated	85-112	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	176-181
18220787-1	2007	Cyclooxygenases (COXs), the enzymes involved in the formation of prostaglandins from polyunsaturated fatty acids such as arachidonic acid, exist in two forms--the constitutive COX-1 that is cytoprotective and responsible for the production of prostaglandins and COX-2 which is induced by cytokines, mitogens and endotoxins in inflammatory cells and responsible for the increased levels of prostaglandins during inflammation.	Fatty Acids, Unsaturated	85-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-267
18018855-0	2007	Relationships between indices for desaturase and elongase activity involved in the intramuscular long chain polyunsaturated fatty acid metabolism in pigs.	Fatty Acids, Unsaturated	108-134	ELOVL fatty acid elongase 5	Sus scrofa	49-57
17305571-3	2007	So, on the basis of these results, it seemed useful to study the advantages of combination of COX inhibitor with LOX inhibitor and a next step will be the conception of dual inhibitors able to induce the anticarcinogenic and/or to inhibit the procarcinogenic enzymes responsible for polyunsaturated fatty acid metabolism.	Fatty Acids, Unsaturated	283-309	cytochrome c oxidase subunit 8A	Homo sapiens	94-97
17310598-8	2007	From the multivariate nutrient density model, substituting polyunsaturated fatty acid for carbohydrate was positively associated with BMI in women aged 20 to 49 (beta = 2.31, p &lt; 0.01).	Fatty Acids, Unsaturated	59-85	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	162-170
17010529-9	2007	Early data suggests beneficial effects of polyunsaturated fatty acid PUFA supplementation and exercise training in combination with appropriate nutritional support may yield rewarding therapeutic benefits.	Fatty Acids, Unsaturated	42-68	pumilio RNA binding family member 3	Homo sapiens	69-73
17176082-0	2006	Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation.	Fatty Acids, Unsaturated	72-99	synuclein alpha	Homo sapiens	0-15
16983391-3	2007	Here, we show that n-3 PUFA deprivation for 15 weeks decreased the frontal cortex DHA level and reduced frontal cortex BDNF expression, cAMP response element binding protein (CREB) transcription factor activity and p38 mitogen-activated protein kinase (MAPK) activity.	Fatty Acids, Unsaturated	23-27	brain-derived neurotrophic factor	Rattus norvegicus	119-123
16983391-3	2007	Here, we show that n-3 PUFA deprivation for 15 weeks decreased the frontal cortex DHA level and reduced frontal cortex BDNF expression, cAMP response element binding protein (CREB) transcription factor activity and p38 mitogen-activated protein kinase (MAPK) activity.	Fatty Acids, Unsaturated	23-27	cAMP responsive element binding protein 1	Rattus norvegicus	136-173
16983391-3	2007	Here, we show that n-3 PUFA deprivation for 15 weeks decreased the frontal cortex DHA level and reduced frontal cortex BDNF expression, cAMP response element binding protein (CREB) transcription factor activity and p38 mitogen-activated protein kinase (MAPK) activity.	Fatty Acids, Unsaturated	23-27	cAMP responsive element binding protein 1	Rattus norvegicus	175-179
16983391-3	2007	Here, we show that n-3 PUFA deprivation for 15 weeks decreased the frontal cortex DHA level and reduced frontal cortex BDNF expression, cAMP response element binding protein (CREB) transcription factor activity and p38 mitogen-activated protein kinase (MAPK) activity.	Fatty Acids, Unsaturated	23-27	mitogen activated protein kinase 14	Rattus norvegicus	215-251
17176111-1	2006	Soybean lipoxygenase-1 (SBLO-1) catalyzes the oxygenation of polyunsaturated fatty acids to produce conjugated diene hydroperoxides.	Fatty Acids, Unsaturated	61-88	linoleate 9S-lipoxygenase-4	Glycine max	8-20
17110924-4	2006	TREK-1 knockout mice have impaired PUFA-mediated neuroprotection to ischemia, reduced sensitivity to volatile anesthetics and altered perception of pain.	Fatty Acids, Unsaturated	35-39	potassium channel, subfamily K, member 2	Mus musculus	0-6
17007889-8	2006	These results suggest that PPARalpha has greater selectivity to certain types of polyunsaturated fatty acids, and that the ligand-induced conformational change of PPARalpha leads to parallel increases in both DNA binding to the PPAR-response element and the DNA binding-independent transactivity.	Fatty Acids, Unsaturated	81-108	peroxisome proliferator activated receptor alpha	Homo sapiens	27-36
17007889-8	2006	These results suggest that PPARalpha has greater selectivity to certain types of polyunsaturated fatty acids, and that the ligand-induced conformational change of PPARalpha leads to parallel increases in both DNA binding to the PPAR-response element and the DNA binding-independent transactivity.	Fatty Acids, Unsaturated	81-108	peroxisome proliferator activated receptor alpha	Homo sapiens	163-172
17007889-8	2006	These results suggest that PPARalpha has greater selectivity to certain types of polyunsaturated fatty acids, and that the ligand-induced conformational change of PPARalpha leads to parallel increases in both DNA binding to the PPAR-response element and the DNA binding-independent transactivity.	Fatty Acids, Unsaturated	81-108	peroxisome proliferator activated receptor alpha	Homo sapiens	27-31
17007889-5	2006	DPSA revealed that polyunsaturated fatty acids of 18 to 20 carbon groups with 3-5 double bonds strongly induced a PPARalpha conformational change.	Fatty Acids, Unsaturated	19-46	peroxisome proliferator activated receptor alpha	Homo sapiens	114-123
17158408-2	2006	It has been hypothesized that the dietary ratio of n-6 to n-3 (n-6:n-3) polyunsaturated fatty acids (PUFAs) may have favorable effects on these risk factors by increasing insulin sensitivity.	Fatty Acids, Unsaturated	72-99	insulin	Homo sapiens	171-178
17005995-3	2006	Dietary PUFAs, especially eicosapentaenoic acid (EPA) in marine oils, improve serum lipid profiles by suppressing liver X receptor alpha (LXRalpha) activity in the liver.	Fatty Acids, Unsaturated	8-13	nuclear receptor subfamily 1 group H member 3	Homo sapiens	138-146
16971577-6	2006	Pollock liver and viscera had the highest total fatty acid concentrations; however, red salmon hydrolysate and SMB had the highest total PUFA concentrations (49.63 and 48.60 mg/g, respectively).	Fatty Acids, Unsaturated	137-141	small nuclear ribonucleoprotein polypeptide N	Gallus gallus	111-114
16901908-0	2006	Receptor-induced activation of Drosophila TRP gamma by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	55-82	Transient receptor potential cation channel gamma	Drosophila melanogaster	42-51
16901908-6	2006	Analysis of the activation mechanism revealed that TRPgamma is activated by various polyunsaturated fatty acids generated in a phospholipase C- and phospholipase A(2)-dependent manner.	Fatty Acids, Unsaturated	84-111	Transient receptor potential cation channel gamma	Drosophila melanogaster	51-59
16901908-6	2006	Analysis of the activation mechanism revealed that TRPgamma is activated by various polyunsaturated fatty acids generated in a phospholipase C- and phospholipase A(2)-dependent manner.	Fatty Acids, Unsaturated	84-111	Phospholipase C at 21C	Drosophila melanogaster	127-142
16901908-8	2006	Here we show that upon heterologous expression TRPgamma forms a homomeric channel complex that is activated by polyunsaturated fatty acids as mediators of receptor-dependent signaling pathways.	Fatty Acids, Unsaturated	111-138	Transient receptor potential cation channel gamma	Drosophila melanogaster	47-55
17023713-8	2006	CONCLUSIONS: Correlation of the mRNA expression of the membrane placental proteins FATP-1 and especially of FATP-4 with maternal and cord DHA leads us to conclude that these lipid carriers are involved in placental transfer of long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	238-265	solute carrier family 27 member 1	Homo sapiens	83-89
17023713-8	2006	CONCLUSIONS: Correlation of the mRNA expression of the membrane placental proteins FATP-1 and especially of FATP-4 with maternal and cord DHA leads us to conclude that these lipid carriers are involved in placental transfer of long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	238-265	solute carrier family 27 member 4	Homo sapiens	108-114
17159810-1	2006	OBJECTIVES: Lipoxygenases (EC 1.13.11.12, LOX) catalyze the hydroperoxidation of polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	81-108	lysyl oxidase	Rattus norvegicus	42-45
17159810-1	2006	OBJECTIVES: Lipoxygenases (EC 1.13.11.12, LOX) catalyze the hydroperoxidation of polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	110-114	lysyl oxidase	Rattus norvegicus	42-45
16982622-7	2006	The contribution of AtECH2 to the degradation of unsaturated fatty acids was assessed by analyzing the carbon flux through the beta-oxidation cycle in plants that synthesize peroxisomal polyhydroxyalkanoate and that were over- or underexpressing the AtECH2 gene.	Fatty Acids, Unsaturated	49-72	enoyl-CoA hydratase 2	Arabidopsis thaliana	20-26
16982622-7	2006	The contribution of AtECH2 to the degradation of unsaturated fatty acids was assessed by analyzing the carbon flux through the beta-oxidation cycle in plants that synthesize peroxisomal polyhydroxyalkanoate and that were over- or underexpressing the AtECH2 gene.	Fatty Acids, Unsaturated	49-72	enoyl-CoA hydratase 2	Arabidopsis thaliana	250-256
17032029-1	2006	The degradation of polyunsaturated fatty acids through the lipoxygenase pathway is responsible for the production of volatile compounds that confer green sensory notes to the aroma of fruits and vegetables.	Fatty Acids, Unsaturated	19-46	lipoxygenase 1	Arabidopsis thaliana	59-71
16862401-9	2006	Theses observations indicate that an intron-mediated regulatory mechanism is involved in controlling not only the seed-specific expression of the SeFAD2 gene but also the expression of plant FAD2 genes, which are essential for the synthesis of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	244-271	omega-6 fatty acid desaturase, endoplasmic reticulum isozyme 2	Sesamum indicum	148-152
16958665-6	2006	Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells that express CYP2E1 (E47 cells) but not control HepG2 cells.	Fatty Acids, Unsaturated	9-36	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	89-95
16524712-1	2006	Clinical trials have revealed that progression of immunoglobulin A nephropathy (IgAN), the most common form of human glomerulonephritis, is inhibited by dietary (n-3) polyunsaturated fatty acid (PUFA) supplementation.	Fatty Acids, Unsaturated	195-199	IGAN1	Homo sapiens	80-84
16940152-1	2006	TRPV4 is a calcium-permeable channel activated by extracellular hypotonicity, polyunsaturated fatty acids, phorbol esters, and heat.	Fatty Acids, Unsaturated	78-105	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	0-5
16854431-7	2006	During hypoxia, efg1 mutants contained lower levels of unsaturated fatty acids, while hyphal morphogenesis on solid media was significantly increased at temperatures &lt;37 degrees C. These results suggest that during oxygen-limitation, Efg1p acts as a repressor of filamentation and as a positive regulator of fatty acid desaturation.	Fatty Acids, Unsaturated	55-78	Efg1p	Saccharomyces cerevisiae S288C	16-20
16925585-5	2006	Unsaturated fatty acids strongly stimulated Rv2212 activity by increasing substrate affinity.	Fatty Acids, Unsaturated	0-23	adenylyl cyclase	Mycobacterium tuberculosis H37Rv	44-50
16925585-8	2006	Rv2212 appears to integrate three cellular parameters: ATP concentration, presence of unsaturated fatty acids, and pH.	Fatty Acids, Unsaturated	86-109	adenylyl cyclase	Mycobacterium tuberculosis H37Rv	0-6
16288935-0	2006	The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women.	Fatty Acids, Unsaturated	134-160	peroxisome proliferator activated receptor alpha	Homo sapiens	30-35
16887993-2	2006	In the present study, Ag presentation of liposome-coupled OVA was investigated in vitro, and it was found that OVA coupled to liposomes made using unsaturated fatty acid was presented to both CD4+ and CD8+ T cells, whereas OVA coupled to liposomes made using saturated fatty acid was presented only to CD4+ T cells.	Fatty Acids, Unsaturated	147-169	CD4 antigen	Mus musculus	192-195
31627634-4	2006	In children, DM-1 was ascertained to be accompanied by not only atherogenic serum lipid metabolic disturbances (the elevated levels of total cholesterol, triglycerides, low- and very low-density lipoprotein cholesterol), but also by the impaired lipid spectrum of erythrocytic membranes (reductions in the level of total lipids and the fraction of phosphatidylcholine (PC) with an increase in the level of fractions of tysophosphatidylcholine and phosphaUdylinositol; elevated levels of saturated fatty acids and decreased levels of unsaturated fatty acids in the fractions of PC and phosphatidylethanolamlne; the enhanced microviscosity of deep membranous layers and the modified outer membranous ones).	Fatty Acids, Unsaturated	533-556	immunoglobulin heavy diversity 1-7	Homo sapiens	13-17
16675724-4	2006	ASO-mediated knockdown of ACAT2 resulted in reduction of total plasma cholesterol, increased levels of plasma triglyceride, and a shift in LDL cholesteryl ester (CE) fatty acid composition from mainly saturated and monounsaturated to polyunsaturated fatty acid enrichment.	Fatty Acids, Unsaturated	234-260	acetyl-Coenzyme A acetyltransferase 2	Mus musculus	26-31
16895544-8	2006	In human umbilical vein endothelial cells, the production of NO and endothelin-1 was significantly inhibited by unsaturated fatty acids.	Fatty Acids, Unsaturated	112-135	endothelin 1	Homo sapiens	68-80
16790029-5	2006	Because of the similarity of its N-terminal portion to the catalytic site of lipases, EDS1 has also been implicated with the release of polyunsaturated fatty acids and the subsequent formation of various oxylipins.	Fatty Acids, Unsaturated	136-163	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	86-90
17076197-4	2006	The prostaglandin 12 especially, all arachidonic acid metabolites and polyunsaturated fatty acids are naturally occuring PPAR ligands.	Fatty Acids, Unsaturated	70-97	peroxisome proliferator activated receptor alpha	Homo sapiens	121-125
16908951-3	2006	AIM: We investigated the relationship between A54T polymorphism in FABP2 and the impairment of long-chain polyunsaturated fatty acid metabolism in obese children.	Fatty Acids, Unsaturated	106-132	fatty acid binding protein 2	Homo sapiens	67-72
16644726-2	2006	n-3 polyunsaturated fatty acids (PUFA) and WY14643 (peroxisome proliferator-activated receptor alpha (PPARalpha) agonist) interfere with glucose-stimulated L-PK gene transcription in vivo and in rat primary hepatocytes.	Fatty Acids, Unsaturated	33-37	pyruvate kinase L/R	Rattus norvegicus	156-160
16763165-1	2006	Several novel polyunsaturated fatty acids (PUFAs) that contain either an oxygen or sulfur atom in the beta-position were found to exhibit more selective antiinflammatory properties than their natural PUFA counterparts.	Fatty Acids, Unsaturated	14-41	pumilio RNA binding family member 3	Homo sapiens	43-47
16685043-8	2006	Compared with the UD, an increase in serum total polyunsaturated fatty acids was also observed (CD: 39.8 +/- 2.6%; LPD: 39.7 +/- 4.4%; UD: 37.3 +/- 3.1%; P = 0.029).	Fatty Acids, Unsaturated	49-76	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	115-118
16825699-1	2006	BACKGROUND: Several studies have reported that the intake of n-3 polyunsaturated fatty acids (PUFAs) or fish is inversely associated with serum C-reactive protein (CRP) concentrations, but few studies have evaluated the relations between serum CRP concentrations and consumption of n-3 PUFAs derived from marine products in populations with a diet rich in marine products.	Fatty Acids, Unsaturated	94-99	C-reactive protein	Homo sapiens	144-162
16825699-1	2006	BACKGROUND: Several studies have reported that the intake of n-3 polyunsaturated fatty acids (PUFAs) or fish is inversely associated with serum C-reactive protein (CRP) concentrations, but few studies have evaluated the relations between serum CRP concentrations and consumption of n-3 PUFAs derived from marine products in populations with a diet rich in marine products.	Fatty Acids, Unsaturated	94-99	C-reactive protein	Homo sapiens	164-167
16825699-1	2006	BACKGROUND: Several studies have reported that the intake of n-3 polyunsaturated fatty acids (PUFAs) or fish is inversely associated with serum C-reactive protein (CRP) concentrations, but few studies have evaluated the relations between serum CRP concentrations and consumption of n-3 PUFAs derived from marine products in populations with a diet rich in marine products.	Fatty Acids, Unsaturated	94-99	C-reactive protein	Homo sapiens	244-247
16829183-8	2006	We conclude that endothelial-generated PAF plays a central role in cytokine-induced monocyte adherence to endothelium and that the anti-inflammatory action of PUFAs such as CLA in suppressing monocyte-endothelial interaction is mediated through attenuation of pro-inflammatory phospholipids such as PAF.	Fatty Acids, Unsaturated	159-164	PCNA clamp associated factor	Homo sapiens	299-302
16626961-3	2006	According to the involvement of oxidative stress and polyunsaturated fatty acids like AA in the regulation of sphingomyelinase (SMase) activity, the present study underlines the role of SMases in soluble Abeta-induced apoptosis.	Fatty Acids, Unsaturated	53-80	amyloid beta precursor protein	Homo sapiens	204-209
16782410-4	2006	PPARalpha is activated by polyunsaturated fatty acids and by fibrate drugs (fenofibrate and gemfibrozil) and controls expression of genes involved in lipid metabolism.	Fatty Acids, Unsaturated	26-53	peroxisome proliferator activated receptor alpha	Homo sapiens	0-9
16782410-7	2006	PPARbeta/delta ligands include polyunsaturated fatty acids, prostaglandins and synthetic compounds and stimulate fatty acid oxidation.	Fatty Acids, Unsaturated	31-58	peroxisome proliferator activated receptor delta	Homo sapiens	0-8
16734744-2	2006	The increased PLA2 activity is seen as an increased release of free, polyunsaturated fatty acids, e.g. arachidonic acid and membrane-bound lysophospholipids.	Fatty Acids, Unsaturated	69-96	phospholipase A2 group IB	Homo sapiens	14-18
16557504-0	2006	Potentiation of TRPV3 channel function by unsaturated fatty acids.	Fatty Acids, Unsaturated	42-65	transient receptor potential cation channel subfamily V member 3	Homo sapiens	16-21
16557504-5	2006	Here we show that AA and other unsaturated fatty acids directly potentiate 2APB-induced responses of TRPV3 expressed in HEK293 cells, Xenopus oocytes, and mouse keratinocytes.	Fatty Acids, Unsaturated	31-54	transient receptor potential cation channel subfamily V member 3	Homo sapiens	101-106
16713180-6	2006	Feeding an n-3 PUFA diet to rats with DP upregulated IL-10 mRNA in the pancreas and IL-4 and IL-10 mRNA in the spleen.	Fatty Acids, Unsaturated	15-19	interleukin 10	Rattus norvegicus	53-58
16713180-6	2006	Feeding an n-3 PUFA diet to rats with DP upregulated IL-10 mRNA in the pancreas and IL-4 and IL-10 mRNA in the spleen.	Fatty Acids, Unsaturated	15-19	interleukin 4	Rattus norvegicus	84-88
16713180-6	2006	Feeding an n-3 PUFA diet to rats with DP upregulated IL-10 mRNA in the pancreas and IL-4 and IL-10 mRNA in the spleen.	Fatty Acids, Unsaturated	15-19	interleukin 10	Rattus norvegicus	93-98
16513294-7	2006	Cytochrome P450 2C45, thought to play a role in biotransformation of steroids and poly-unsaturated fatty acids, was more expressed in lean chickens whereas fatty acid synthase, stearoyl-CoA desaturase, sterol response element binding factor 1 and hepatocyte nuclear factor 4, respectively involved in lipogenesis and its regulation, were more expressed in fat chickens.	Fatty Acids, Unsaturated	82-110	cytochrome P450 family 2 subfamily C member 18	Gallus gallus	0-20
16648288-1	2006	Peroxisome proliferator-activated receptors (PPARalpha, PPARbeta/delta and PPARgamma) are a family of nuclear receptors that are activated by binding of natural ligands, such as polyunsaturated fatty acids or by synthetic ligands.	Fatty Acids, Unsaturated	178-205	peroxisome proliferator activated receptor alpha	Homo sapiens	45-54
16624646-11	2006	The percentage of unsaturated fatty acids increased 48 h after CCl4 treatment, but its value was 0.5 times lower in the group receiving A. maxima than in the group fed without A. maxima.	Fatty Acids, Unsaturated	18-41	C-C motif chemokine ligand 4	Rattus norvegicus	63-67
16601147-0	2006	Polyunsaturated fatty acids mobilize intracellular Ca2+ in NT2 human teratocarcinoma cells by causing release of Ca2+ from mitochondria.	Fatty Acids, Unsaturated	0-27	carbonic anhydrase 2	Homo sapiens	51-54
16601147-0	2006	Polyunsaturated fatty acids mobilize intracellular Ca2+ in NT2 human teratocarcinoma cells by causing release of Ca2+ from mitochondria.	Fatty Acids, Unsaturated	0-27	carbonic anhydrase 2	Homo sapiens	113-116
16601147-4	2006	Polyunsaturated FA (PUFA) have been shown to cause [Ca(2+)](i) mobilization albeit by unknown mechanisms.	Fatty Acids, Unsaturated	0-18	pumilio RNA binding family member 3	Homo sapiens	20-24
16648288-1	2006	Peroxisome proliferator-activated receptors (PPARalpha, PPARbeta/delta and PPARgamma) are a family of nuclear receptors that are activated by binding of natural ligands, such as polyunsaturated fatty acids or by synthetic ligands.	Fatty Acids, Unsaturated	178-205	peroxisome proliferator activated receptor delta	Homo sapiens	56-64
16648288-1	2006	Peroxisome proliferator-activated receptors (PPARalpha, PPARbeta/delta and PPARgamma) are a family of nuclear receptors that are activated by binding of natural ligands, such as polyunsaturated fatty acids or by synthetic ligands.	Fatty Acids, Unsaturated	178-205	peroxisome proliferator activated receptor gamma	Homo sapiens	75-84
16476439-2	2006	Arachidonic acid, one of the major unsaturated fatty acids released during cell stimulation, participates in the signaling necessary for activation of different enzymes, including protein kinase C (PKC).	Fatty Acids, Unsaturated	35-58	protein kinase C alpha	Homo sapiens	198-201
16611275-7	2006	RESULTS: Polyunsaturated fatty acid supplementation significantly decreased serum aspartate transaminase (P = 0.003), alanine transaminase (P = 0.002), gamma-glutamyl transpeptidase (P = 0.03), triglycerides (P = 0.02) and fasting glucose (P = 0.02) in comparison with controls.	Fatty Acids, Unsaturated	9-35	inactive glutathione hydrolase 2	Homo sapiens	152-181
16564093-8	2006	To generalize, the fatty acid elongases can be divided into two major groups: (a) enzymes which are suggested to be involved in the elongation of saturated and monounsaturated VLCFA (ELOVL1, 3 and 6) and (b) enzymes which are elongases of polyunsaturated fatty acids (PUFA) (ELOVL2, 4 and 5).	Fatty Acids, Unsaturated	239-266	ELOVL fatty acid elongase 1	Homo sapiens	183-198
16564093-8	2006	To generalize, the fatty acid elongases can be divided into two major groups: (a) enzymes which are suggested to be involved in the elongation of saturated and monounsaturated VLCFA (ELOVL1, 3 and 6) and (b) enzymes which are elongases of polyunsaturated fatty acids (PUFA) (ELOVL2, 4 and 5).	Fatty Acids, Unsaturated	268-272	ELOVL fatty acid elongase 1	Homo sapiens	183-198
16698313-3	2006	In the present study, we examined the effects of DHA and other polyunsaturated fatty acids (PUFA) on TNF-induced necrosis, another mode of cell death, using L929 murine fibrosarcoma cells.	Fatty Acids, Unsaturated	63-90	tumor necrosis factor	Mus musculus	101-104
16363994-1	2006	The Rsp5 ubiquitin ligase plays a role in many cellular processes including the biosynthesis of unsaturated fatty acids.	Fatty Acids, Unsaturated	96-119	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	4-8
16363994-8	2006	Analysis of lipid extracts revealed the accumulation of saturated fatty acids in the rsp5 mutant, as a consequence of the prevention of unsaturated fatty acid synthesis.	Fatty Acids, Unsaturated	136-158	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	85-89
16698313-12	2006	These observations suggested that attenuation of TNF-induced necrosis by the supplementation of various C20 or C22 polyunsaturated fatty acids is mainly attributable to the enrichment of three kinds of polyunsaturated fatty acids, i.e., DHA, DPAn-3 or AA, in phospholipids.	Fatty Acids, Unsaturated	115-142	tumor necrosis factor	Mus musculus	49-52
16554040-10	2006	This raises the possibility that increased SREBP-1 expression secondary to aging-related decline of polyunsaturated fatty acid (PUFA) might compensate for the reduction of FAS expression in brain.	Fatty Acids, Unsaturated	100-126	sterol regulatory element binding transcription factor 1	Rattus norvegicus	43-50
16554040-10	2006	This raises the possibility that increased SREBP-1 expression secondary to aging-related decline of polyunsaturated fatty acid (PUFA) might compensate for the reduction of FAS expression in brain.	Fatty Acids, Unsaturated	128-132	sterol regulatory element binding transcription factor 1	Rattus norvegicus	43-50
16698313-3	2006	In the present study, we examined the effects of DHA and other polyunsaturated fatty acids (PUFA) on TNF-induced necrosis, another mode of cell death, using L929 murine fibrosarcoma cells.	Fatty Acids, Unsaturated	92-96	tumor necrosis factor	Mus musculus	101-104
16698313-12	2006	These observations suggested that attenuation of TNF-induced necrosis by the supplementation of various C20 or C22 polyunsaturated fatty acids is mainly attributable to the enrichment of three kinds of polyunsaturated fatty acids, i.e., DHA, DPAn-3 or AA, in phospholipids.	Fatty Acids, Unsaturated	115-142	Sp7 transcription factor 7	Mus musculus	111-114
16388966-5	2006	Some long-chain polyunsaturated fatty acids, arachidonic acid metabolites and fatty acid derived components are natural ligands of PPAR-gamma.	Fatty Acids, Unsaturated	16-43	peroxisome proliferator activated receptor gamma	Homo sapiens	131-141
16497344-1	2006	Fatty acid 9/13-hydroperoxide lyase (9/13-HPL) in cucumber is an enzyme that can cleave either 9- or 13-hydroperoxides of polyunsaturated fatty acids to form C9- or C6-aldehydes, respectively, as products.	Fatty Acids, Unsaturated	122-149	allene oxide synthase, chloroplastic-like	Cucumis sativus	42-45
16565407-10	2006	DHA, the retina major polyunsaturated fatty acid, which protects photoreceptors from oxidative stress-induced apoptosis, completely blocked C2-ceramide-induced photoreceptor death, simultaneously increasing Bcl-2 expression.	Fatty Acids, Unsaturated	22-48	BCL2 apoptosis regulator	Homo sapiens	207-212
16263169-4	2006	Our objective was to determine whether immune-enhancing ingredients, such as arginine, isoleucine, and polyunsaturated fatty acids (PUFA), which are added to immune-enhancing formulas, mediate their beneficial activity by bolstering the immune system through hBD-1 induction.	Fatty Acids, Unsaturated	103-130	defensin beta 1	Homo sapiens	259-264
16263169-4	2006	Our objective was to determine whether immune-enhancing ingredients, such as arginine, isoleucine, and polyunsaturated fatty acids (PUFA), which are added to immune-enhancing formulas, mediate their beneficial activity by bolstering the immune system through hBD-1 induction.	Fatty Acids, Unsaturated	132-136	defensin beta 1	Homo sapiens	259-264
17100291-8	2006	It was found that administration of NSE to tumor-bearing mice contributed to the increase of cholesterol level, to the decrease of omega-6/omega-3 ratio polyunsaturated fatty acids of total phospholipids.	Fatty Acids, Unsaturated	153-180	enolase 2, gamma neuronal	Mus musculus	36-39
16478242-0	2006	Prolyl endopeptidase inhibitory activity of unsaturated fatty acids.	Fatty Acids, Unsaturated	44-67	prolyl endopeptidase	Homo sapiens	0-20
16478242-6	2006	Dixon plots of PEP inhibition showed oleic, linoleic, and arachidonic acids, EPA, and DHA are noncompetitive inhibitors; despite higher IC50 values of these unsaturated fatty acids than strong natural inhibitors, they may have potential use in preventing memory loss.	Fatty Acids, Unsaturated	157-180	prolyl endopeptidase	Homo sapiens	15-18
15885896-5	2006	In addition, we stimulated CRL-1790 cell line with linoleic acid (a polyunsaturated fatty acid) for 12, 24, 48 and 72 h. Cell proliferation was elevated by 5, 25, 28 and 31% (P&lt;0.05), respectively.	Fatty Acids, Unsaturated	68-94	interleukin 31 receptor A	Homo sapiens	27-30
16337744-7	2006	In this regard, the recently delineated interplay between COX-2-derived PG signaling and other growth-regulatory pathways such as EGFR, Met, iNOS, VEGF and n-3 polyunsaturated fatty acids is expected to provide important therapeutic implications.	Fatty Acids, Unsaturated	160-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16188912-4	2006	In the mice fed a normal diet, CLA/PUFA supplementation resulted in insulin resistance associated with low plasma adiponectin levels and low body fat content.	Fatty Acids, Unsaturated	35-39	adiponectin, C1Q and collagen domain containing	Mus musculus	114-125
16188912-8	2006	It is concluded that dietary supplementation of CLA/PUFA in mice fed the normal diet augments insulin secretion, partly because of increased islet glucose oxidation, but that this augmentation is insufficient to counterbalance the induction of insulin resistance, resulting in glucose intolerance.	Fatty Acids, Unsaturated	52-56	clasper	Mus musculus	48-51
16484720-5	2006	The immobilized lipase could be used for different oil conversion and preferred unsaturated fatty acids such as oleic acid to saturated fatty acids such as palmitic acid.	Fatty Acids, Unsaturated	80-103	GDSL esterase/lipase At5g18430-like	Gossypium hirsutum	16-22
16397791-0	2006	Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet.	Fatty Acids, Unsaturated	0-27	adiponectin, C1Q and collagen domain containing	Mus musculus	52-63
17005920-1	2006	Most plant oxylipins, a large class of diverse oxygenated polyunsaturated fatty acids and their derivatives, are produced through the lipoxygenase (LOX) pathway.	Fatty Acids, Unsaturated	58-85	linoleate 9S-lipoxygenase4	Zea mays	134-146
16234304-12	2006	CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders.	Fatty Acids, Unsaturated	45-50	interleukin 6	Homo sapiens	166-170
16234304-12	2006	CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders.	Fatty Acids, Unsaturated	45-50	interleukin 1 receptor antagonist	Homo sapiens	172-178
16234304-12	2006	CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders.	Fatty Acids, Unsaturated	45-50	tumor necrosis factor	Homo sapiens	180-188
16234304-12	2006	CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders.	Fatty Acids, Unsaturated	45-50	C-reactive protein	Homo sapiens	190-208
16234304-12	2006	CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders.	Fatty Acids, Unsaturated	45-50	interleukin 6 receptor	Homo sapiens	265-270
16234304-12	2006	CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders.	Fatty Acids, Unsaturated	45-50	interleukin 10	Homo sapiens	272-277
16234304-12	2006	CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders.	Fatty Acids, Unsaturated	45-50	transforming growth factor beta 1	Homo sapiens	279-286
16105858-0	2006	Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism.	Fatty Acids, Unsaturated	136-140	lecithin cholesterol acyltransferase	Mus musculus	94-98
16146428-5	2006	Additionally, increasing concentrations of unsaturated fatty acids diminished the oxidation and nitration of alpha-syn upon exposure to fluxes of peroxynitrite (8-20 microM x min(-1)).	Fatty Acids, Unsaturated	43-66	synuclein alpha	Homo sapiens	109-118
16910164-11	2006	In contrast, polyunsaturated fatty acids increase plasma insulin concentration and decrease insulin resistance.	Fatty Acids, Unsaturated	13-40	insulin	Homo sapiens	57-64
16910164-11	2006	In contrast, polyunsaturated fatty acids increase plasma insulin concentration and decrease insulin resistance.	Fatty Acids, Unsaturated	13-40	insulin	Homo sapiens	92-99
16406364-0	2006	First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands.	Fatty Acids, Unsaturated	80-106	cannabinoid receptor 2	Homo sapiens	115-118
16275640-4	2006	Polyunsaturated fatty acids of the C18 and C20 series containing at least three double bonds located from carbon 9 (or closer to the carboxyl group) were equally effective as AA in restoring 5-LO translocation in pyrrophenone-treated agonist-activated PMN.	Fatty Acids, Unsaturated	0-27	Bardet-Biedl syndrome 9	Homo sapiens	35-38
17005920-1	2006	Most plant oxylipins, a large class of diverse oxygenated polyunsaturated fatty acids and their derivatives, are produced through the lipoxygenase (LOX) pathway.	Fatty Acids, Unsaturated	58-85	linoleate 9S-lipoxygenase4	Zea mays	148-151
15857162-1	2006	Polyunsaturated fatty acids of n-3 series (n-3 PUFA) were shown to increase basal fat oxidation in humans.	Fatty Acids, Unsaturated	0-27	pumilio RNA binding family member 3	Homo sapiens	47-51
16399491-0	2006	Modulation of plasma cholesteryl ester transfer protein activity by unsaturated fatty acids in Tunisian type 2 diabetic women.	Fatty Acids, Unsaturated	68-91	cholesteryl ester transfer protein	Homo sapiens	21-55
16118212-6	2005	Unsaturated but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-butanol prevented the unsaturated fatty acid-induced reduction in ABCA1 levels, and the PLD2 activator mastoparan markedly reduced ABCA1 protein levels, implicating a role for PLD2 in the ABCA1 destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	127-149	ATP binding cassette subfamily A member 1	Homo sapiens	236-241
16351764-6	2005	In the transient transfection experiment, unsaturated fatty acid increased rat CRBPII gene promoter activity via the PPARalpha/retinoid X receptor-alpha heterodimer.	Fatty Acids, Unsaturated	42-64	retinol binding protein 2	Rattus norvegicus	79-85
16351764-6	2005	In the transient transfection experiment, unsaturated fatty acid increased rat CRBPII gene promoter activity via the PPARalpha/retinoid X receptor-alpha heterodimer.	Fatty Acids, Unsaturated	42-64	peroxisome proliferator activated receptor alpha	Rattus norvegicus	117-126
16351764-6	2005	In the transient transfection experiment, unsaturated fatty acid increased rat CRBPII gene promoter activity via the PPARalpha/retinoid X receptor-alpha heterodimer.	Fatty Acids, Unsaturated	42-64	retinoid X receptor alpha	Rattus norvegicus	127-152
16503871-4	2005	PPARalpha is activated by endogenous ligands, such as polyunsaturated fatty acids and by synthetic agonists such as the fibrates.	Fatty Acids, Unsaturated	54-81	peroxisome proliferator activated receptor alpha	Homo sapiens	0-9
16106047-0	2005	Peroxisome proliferator-activated receptor alpha is required for feedback regulation of highly unsaturated fatty acid synthesis.	Fatty Acids, Unsaturated	95-117	peroxisome proliferator activated receptor alpha	Mus musculus	0-48
16106047-1	2005	Delta6 desaturase (D6D), the rate-limiting enzyme for highly unsaturated fatty acid (HUFA) synthesis, is induced by essential fatty acid-deficient diets.	Fatty Acids, Unsaturated	61-83	fatty acid desaturase 2	Mus musculus	0-17
16106047-1	2005	Delta6 desaturase (D6D), the rate-limiting enzyme for highly unsaturated fatty acid (HUFA) synthesis, is induced by essential fatty acid-deficient diets.	Fatty Acids, Unsaturated	61-83	fatty acid desaturase 2	Mus musculus	19-22
16118212-0	2005	Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	54-59
16118212-3	2005	Unsaturated fatty acids, which are elevated in diabetes, impair the ABCA1 pathway in cultured cells by destabilizing ABCA1 protein.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	68-73
16118212-3	2005	Unsaturated fatty acids, which are elevated in diabetes, impair the ABCA1 pathway in cultured cells by destabilizing ABCA1 protein.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	117-122
16118212-6	2005	Unsaturated but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-butanol prevented the unsaturated fatty acid-induced reduction in ABCA1 levels, and the PLD2 activator mastoparan markedly reduced ABCA1 protein levels, implicating a role for PLD2 in the ABCA1 destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	127-149	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	89-92
16118212-6	2005	Unsaturated but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-butanol prevented the unsaturated fatty acid-induced reduction in ABCA1 levels, and the PLD2 activator mastoparan markedly reduced ABCA1 protein levels, implicating a role for PLD2 in the ABCA1 destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	127-149	ATP binding cassette subfamily A member 1	Homo sapiens	171-176
16118212-6	2005	Unsaturated but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-butanol prevented the unsaturated fatty acid-induced reduction in ABCA1 levels, and the PLD2 activator mastoparan markedly reduced ABCA1 protein levels, implicating a role for PLD2 in the ABCA1 destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	127-149	ATP binding cassette subfamily A member 1	Homo sapiens	236-241
16118212-6	2005	Unsaturated but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-butanol prevented the unsaturated fatty acid-induced reduction in ABCA1 levels, and the PLD2 activator mastoparan markedly reduced ABCA1 protein levels, implicating a role for PLD2 in the ABCA1 destabilizing effects of fatty acids.	Fatty Acids, Unsaturated	127-149	phospholipase D2	Homo sapiens	281-285
16221546-1	2006	We have demonstrated that downregulation of proliferation by CD4(+) T-cells in mice fed n-3 PUFA diets is dependent on the involvement of CD28.	Fatty Acids, Unsaturated	92-96	CD4 antigen	Mus musculus	61-64
16221546-1	2006	We have demonstrated that downregulation of proliferation by CD4(+) T-cells in mice fed n-3 PUFA diets is dependent on the involvement of CD28.	Fatty Acids, Unsaturated	92-96	CD28 antigen	Mus musculus	138-142
16319806-6	2005	Higher levels of membrane saturated fatty acids seem to greatly impair the action of insulin, whereas the presence of polyunsaturated fatty acids, especially of the omega-3 and -6 families, in contrast, improves insulin sensitivity.	Fatty Acids, Unsaturated	118-145	insulin	Homo sapiens	212-219
16339936-7	2005	Saturated fatty acids were the strongest inducers for LIP1 expression and this induction was suppressed proportionally by the presence of the unsaturated fatty acid.	Fatty Acids, Unsaturated	142-164	sphingosine N-acyltransferase subunit LIP1	Saccharomyces cerevisiae S288C	54-58
16366033-1	2005	We investigated the influence of polyunsaturated fatty acids on the activity of the cytosolic phospholipase A2 (cPLA2) in the canine mastocytoma cell line C2 as a model for canine atopic dermatitis (CAD).	Fatty Acids, Unsaturated	33-60	phospholipase A2 group IVA	Canis lupus familiaris	84-110
16366033-1	2005	We investigated the influence of polyunsaturated fatty acids on the activity of the cytosolic phospholipase A2 (cPLA2) in the canine mastocytoma cell line C2 as a model for canine atopic dermatitis (CAD).	Fatty Acids, Unsaturated	33-60	phospholipase A2 group IVA	Canis lupus familiaris	112-117
16140264-7	2005	From the present results, it is suggested that XN acts on FXR through a selective bile acid receptor modulator (SBARM) like guggulsterone or polyunsaturated fatty acids, which have previously been reported as SBARMs.	Fatty Acids, Unsaturated	141-168	nuclear receptor subfamily 1, group H, member 4	Mus musculus	58-61
16118212-7	2005	Unsaturated fatty acids and mastoparan increased phosphorylation of ABCA1 serines.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	68-73
16169525-5	2005	The results indicate that the anti-inflammatory effects of polyunsaturated fatty acids may be, in part, due to the inhibition of NF-kappaB activation via activation of PPARgamma.	Fatty Acids, Unsaturated	59-86	peroxisome proliferator activated receptor gamma	Homo sapiens	168-177
16118212-8	2005	PLD2 small interfering RNA abolished the ability of unsaturated fatty acids to inhibit lipid transport activity, to reduce protein levels, and to increase serine phosphorylation of ABCA1.	Fatty Acids, Unsaturated	52-75	phospholipase D2	Homo sapiens	0-4
16118212-8	2005	PLD2 small interfering RNA abolished the ability of unsaturated fatty acids to inhibit lipid transport activity, to reduce protein levels, and to increase serine phosphorylation of ABCA1.	Fatty Acids, Unsaturated	52-75	ATP binding cassette subfamily A member 1	Homo sapiens	181-186
16132959-7	2005	PPARGC1A expression was increased two- to three-fold by all unsaturated fatty acids (UFAs) tested (p&lt;0.05 each, n=5).	Fatty Acids, Unsaturated	60-83	PPARG coactivator 1 alpha	Homo sapiens	0-8
16132959-7	2005	PPARGC1A expression was increased two- to three-fold by all unsaturated fatty acids (UFAs) tested (p&lt;0.05 each, n=5).	Fatty Acids, Unsaturated	85-89	PPARG coactivator 1 alpha	Homo sapiens	0-8
15917432-11	2005	The GG diet and the PUFA diet were both associated with reduction in caveolin, PAF, and DG content in microdomains, whereas no change occurred in the ganglioside profile of animals fed the PUFA diet.	Fatty Acids, Unsaturated	20-24	PCNA clamp associated factor	Rattus norvegicus	79-82
16006535-0	2005	Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils.	Fatty Acids, Unsaturated	78-104	NSFL1 cofactor	Rattus norvegicus	24-27
16184193-0	2005	Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation.	Fatty Acids, Unsaturated	0-27	MLX interacting protein-like	Mus musculus	94-100
16184193-4	2005	We demonstrated in mice, both in vivo and in vitro, that PUFAs [linoleate (C18:2), eicosapentanoic acid (C20:5), and docosahexaenoic acid (C22:6)] suppressed ChREBP activity by increasing ChREBP mRNA decay and by altering ChREBP translocation from the cytosol to the nucleus, independently of an activation of the AMP-activated protein kinase, previously shown to regulate ChREBP activity.	Fatty Acids, Unsaturated	57-62	MLX interacting protein-like	Mus musculus	158-164
16184193-4	2005	We demonstrated in mice, both in vivo and in vitro, that PUFAs [linoleate (C18:2), eicosapentanoic acid (C20:5), and docosahexaenoic acid (C22:6)] suppressed ChREBP activity by increasing ChREBP mRNA decay and by altering ChREBP translocation from the cytosol to the nucleus, independently of an activation of the AMP-activated protein kinase, previously shown to regulate ChREBP activity.	Fatty Acids, Unsaturated	57-62	MLX interacting protein-like	Mus musculus	188-194
16184193-4	2005	We demonstrated in mice, both in vivo and in vitro, that PUFAs [linoleate (C18:2), eicosapentanoic acid (C20:5), and docosahexaenoic acid (C22:6)] suppressed ChREBP activity by increasing ChREBP mRNA decay and by altering ChREBP translocation from the cytosol to the nucleus, independently of an activation of the AMP-activated protein kinase, previously shown to regulate ChREBP activity.	Fatty Acids, Unsaturated	57-62	MLX interacting protein-like	Mus musculus	188-194
16184193-4	2005	We demonstrated in mice, both in vivo and in vitro, that PUFAs [linoleate (C18:2), eicosapentanoic acid (C20:5), and docosahexaenoic acid (C22:6)] suppressed ChREBP activity by increasing ChREBP mRNA decay and by altering ChREBP translocation from the cytosol to the nucleus, independently of an activation of the AMP-activated protein kinase, previously shown to regulate ChREBP activity.	Fatty Acids, Unsaturated	57-62	MLX interacting protein-like	Mus musculus	188-194
16550486-8	2005	Our results provide evidence that the inward rectification in Drosophila retinal photoreceptors is mediated by ClC-2-like channels in the non-transducing (extra-rhabdomeral) plasma membrane, and that this inward rectification can be modulated by polyunsaturated fatty acid.	Fatty Acids, Unsaturated	246-272	chloride voltage-gated channel 2	Rattus norvegicus	111-116
16140878-7	2005	Although unsaturated fatty acids increase cholesterol synthesis, they also increase hepatic LDL receptor number and LDL turnover in vivo.	Fatty Acids, Unsaturated	9-32	low density lipoprotein receptor	Homo sapiens	92-104
15869467-1	2005	Cyclo-oxygenases-1/2 (COX-1/2) catalyse the oxygenation of AA (arachidonic acid) and related polyunsaturated fatty acids to endoperoxide precursors of prostanoids.	Fatty Acids, Unsaturated	93-120	prostaglandin-endoperoxide synthase 1	Homo sapiens	0-20
15869467-1	2005	Cyclo-oxygenases-1/2 (COX-1/2) catalyse the oxygenation of AA (arachidonic acid) and related polyunsaturated fatty acids to endoperoxide precursors of prostanoids.	Fatty Acids, Unsaturated	93-120	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	22-29
16020546-10	2005	These results suggest a previously unrecognized role for ACAD-9 in the mitochondrial beta-oxidation of long-chain unsaturated fatty acids.	Fatty Acids, Unsaturated	114-137	acyl-CoA dehydrogenase family member 9	Homo sapiens	57-63
16020546-11	2005	Because of the substrate specificity and abundance of ACAD-9 in brain, we speculate that it may play a role in the turnover of lipid membrane unsaturated fatty acids that are essential for membrane integrity and structure.	Fatty Acids, Unsaturated	142-165	acyl-CoA dehydrogenase family member 9	Homo sapiens	54-60
16141315-7	2005	In previous studies with cultured cells, proteolytic activation of SREBP-1a and SREBP-2 has been observed in response to selective starvation of cells for cholesterol and unsaturated fatty acids.	Fatty Acids, Unsaturated	171-194	sterol regulatory element binding transcription factor 1	Homo sapiens	67-75
16141315-7	2005	In previous studies with cultured cells, proteolytic activation of SREBP-1a and SREBP-2 has been observed in response to selective starvation of cells for cholesterol and unsaturated fatty acids.	Fatty Acids, Unsaturated	171-194	sterol regulatory element binding transcription factor 2	Homo sapiens	80-87
16112614-3	2005	In in vitro studies, polyunsaturated fatty acids (PUFAs, n-6, n-3) inhibited binding of LXRalpha/RXRalpha heterodimer to LXR responsive elements (LXREs) in the SREBP-1c promoter.	Fatty Acids, Unsaturated	21-48	nuclear receptor subfamily 1, group H, member 3	Mus musculus	88-91
16112614-3	2005	In in vitro studies, polyunsaturated fatty acids (PUFAs, n-6, n-3) inhibited binding of LXRalpha/RXRalpha heterodimer to LXR responsive elements (LXREs) in the SREBP-1c promoter.	Fatty Acids, Unsaturated	21-48	sterol regulatory element binding transcription factor 1	Mus musculus	160-168
16052213-9	2005	Protein degradation induced by Ang II was inhibited by insulin-like growth factor and by the polyunsaturated fatty acid, eicosapentaenoic acid.	Fatty Acids, Unsaturated	93-119	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	31-37
16019049-3	2005	Addition of ethanol or an unsaturated fatty acid such as arachidonic acid or iron was toxic to the CYP2E1-expressing cells but not control cells.	Fatty Acids, Unsaturated	26-48	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	99-105
15916750-2	2005	The mechanism of AMPK activation by SCD1 mutation is unknown, however since SCD1-/- animals have increased relative amounts of polyunsaturated fatty acids (PUFA), we hypothesized that the increased levels of PUFA might be responsible for the activation of AMPK in SCD1 deficient mice.	Fatty Acids, Unsaturated	127-154	stearoyl-Coenzyme A desaturase 1	Mus musculus	76-80
16043032-0	2005	Altered NF-kappaB gene expression and collagen formation induced by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	68-95	nuclear factor kappa B subunit 1	Homo sapiens	8-17
16142650-1	2005	Enzymatic thrombin activity is significantly inhibited only by a few selected natural phenolic compounds (myricetin, rosmarinic acid, caffeic acid phenethyl ester) but more strongly by unsaturated fatty acids like erucic acid and oleic acids.	Fatty Acids, Unsaturated	185-208	coagulation factor II, thrombin	Homo sapiens	10-18
15975553-8	2005	These results strongly suggest that elo68alpha is involved in the elongation of short unsaturated fatty acids in males and might play a role in vaccenyl acetate biosynthesis.	Fatty Acids, Unsaturated	86-109	Elongase 68alpha	Drosophila melanogaster	36-46
15916750-2	2005	The mechanism of AMPK activation by SCD1 mutation is unknown, however since SCD1-/- animals have increased relative amounts of polyunsaturated fatty acids (PUFA), we hypothesized that the increased levels of PUFA might be responsible for the activation of AMPK in SCD1 deficient mice.	Fatty Acids, Unsaturated	127-154	stearoyl-Coenzyme A desaturase 1	Mus musculus	76-80
15956459-2	2005	Polyunsaturated fatty acids decrease ADD1 mRNA abundance in differentiating porcine adipocytes.	Fatty Acids, Unsaturated	0-27	adducin 1	Homo sapiens	37-41
16288576-3	2005	The aim of our study was to analyse the relation between polyunsaturated fatty acid intake and CD4 count in HIV infected patients.	Fatty Acids, Unsaturated	57-83	CD4 molecule	Homo sapiens	95-98
15980250-0	2005	Dietary ganglioside and long-chain polyunsaturated fatty acids increase ganglioside GD3 content and alter the phospholipid profile in neonatal rat retina.	Fatty Acids, Unsaturated	35-62	GRDX	Homo sapiens	84-87
16037257-4	2005	Cholesterol esterified with these polyunsaturated fatty acids (PUFAs) is readily oxidized at the PUFA residue during storage and heating.	Fatty Acids, Unsaturated	34-61	pumilio RNA binding family member 3	Homo sapiens	63-67
15917152-0	2005	Polyunsaturated fatty acids (PUFAs) might reduce hot flushes: an indication from two controlled trials on soy isoflavones alone and with a PUFA supplement.	Fatty Acids, Unsaturated	0-27	pumilio RNA binding family member 3	Homo sapiens	29-33
15799963-0	2005	Unsaturated fatty acids induce cytotoxic aggregate formation of amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutants.	Fatty Acids, Unsaturated	0-23	superoxide dismutase 1	Homo sapiens	101-123
15799963-7	2005	Heat-treated holo-SOD1 mutants were readily oligomerized by the addition of unsaturated FAs, whereas wild-type SOD1 was not.	Fatty Acids, Unsaturated	76-91	superoxide dismutase 1	Homo sapiens	18-22
15921978-3	2005	Chemo-enzymatic epoxidation of unsaturated fatty acids (oleic, linoleic and linolenic acid, respectively) has been performed using hydrogen peroxide and immobilized lipase from Candida antarctica (Novozym 435).	Fatty Acids, Unsaturated	31-54	PAN0_003d1715	Moesziomyces antarcticus	165-171
15949697-2	2005	PPARalpha, activated by polyunsaturated fatty acids and fibrates, is implicated in regulation of lipid metabolism, lipoprotein synthesis and metabolism and inflammatory response in liver and other tissues.	Fatty Acids, Unsaturated	24-51	peroxisome proliferator activated receptor alpha	Homo sapiens	0-9
15845283-1	2005	Diet-induced changes in the polyunsaturated fatty acid (PUFA) content of immune cells influences the immune phenotype that develops following infection.	Fatty Acids, Unsaturated	56-60	PUFA	Bos taurus	28-54
15774422-6	2005	In contrast to the similar affinities of PPAR alpha for fatty acyl-CoAs and unsaturated fatty acids, CoA thioesters of peroxisome proliferator drugs were bound with 5-6-fold higher affinities than their free acid forms.	Fatty Acids, Unsaturated	76-99	peroxisome proliferator activated receptor alpha	Homo sapiens	41-51
15774422-7	2005	Circular dichroism demonstrated that high affinity ligands (long chain fatty acyl-CoAs, unsaturated fatty acids), but not weak affinity ligands (saturated fatty acids), elicited conformational changes in PPAR alpha structure, a hallmark of ligand-activated nuclear receptors.	Fatty Acids, Unsaturated	88-111	peroxisome proliferator activated receptor alpha	Homo sapiens	204-214
15886305-4	2005	This promise is illustrated by recent studies of 15-hydroxyprostaglandin dehydrogenase, which plays a critical role in polyunsaturated fatty acid metabolism and (like another important target, prostacyclin) is downstream of cyclooxygenase-2.	Fatty Acids, Unsaturated	119-145	carbonyl reductase 1	Homo sapiens	49-86
15774422-9	2005	In summary, since nuclear concentrations of these ligands are in the nanomolar range, long chain fatty acyl-CoAs and unsaturated fatty acids may both represent endogenous PPAR alpha ligands.	Fatty Acids, Unsaturated	117-140	peroxisome proliferator activated receptor alpha	Homo sapiens	171-181
15855323-1	2005	Fatty acid desaturases such as steaoryl-CoA desaturase (SCD) convert saturated to unsaturated fatty acids and are involved in lipogenesis.	Fatty Acids, Unsaturated	82-105	stearoyl-CoA desaturase	Homo sapiens	31-54
16054080-2	2005	We examined the role of n-3 polyunsaturated fatty acid (PUFA) in peripheral leptin resistance.	Fatty Acids, Unsaturated	56-60	leptin	Homo sapiens	76-82
15588254-0	2005	Probing conformational changes of human serum albumin due to unsaturated fatty acid binding by chemical cross-linking and mass spectrometry.	Fatty Acids, Unsaturated	61-83	albumin	Homo sapiens	40-53
15868283-2	2005	Because PUFAs have been reported to activate peroxisome proliferator-activated receptors (PPARs), we investigated the expression of these nuclear receptors in human primary osteoblastic (hOB) cells and examined the effects of natural PPAR ligands on hOB cell proliferation.	Fatty Acids, Unsaturated	8-13	peroxisome proliferator activated receptor alpha	Homo sapiens	90-94
15855323-1	2005	Fatty acid desaturases such as steaoryl-CoA desaturase (SCD) convert saturated to unsaturated fatty acids and are involved in lipogenesis.	Fatty Acids, Unsaturated	82-105	stearoyl-CoA desaturase	Homo sapiens	56-59
15850715-4	2005	Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance.	Fatty Acids, Unsaturated	11-38	insulin	Homo sapiens	107-114
16233825-0	2005	High expression of unsaturated fatty acid synthesis gene OLE 1 in sake yeasts.	Fatty Acids, Unsaturated	19-41	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	57-62
16233825-4	2005	Unsaturated fatty acid concentrations in strain K 7 are higher than that in strain X 2180-1A, suggesting that the higher expression level of OLE 1 in sake yeasts increases the unsaturated fatty acid content in the cell membrane.	Fatty Acids, Unsaturated	0-22	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	141-146
16233825-4	2005	Unsaturated fatty acid concentrations in strain K 7 are higher than that in strain X 2180-1A, suggesting that the higher expression level of OLE 1 in sake yeasts increases the unsaturated fatty acid content in the cell membrane.	Fatty Acids, Unsaturated	176-198	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	141-146
15703198-4	2005	In T cells treated with the PUFA eicosapentaenoic (EPA; 20:5,n-3) and arachidonic acid (20:4,n-6), stimulated by superantigen-presenting cells or APCs, relocalization to the IS of distinct molecules [F-actin, talin, leukocyte functional antigen-1alpha, clusters of differentiation (CD)3epsilon] was inhibited markedly compared with cells treated with saturated fatty acid, whereas relocalization of protein kinase Ctheta to the IS remained unaffected.	Fatty Acids, Unsaturated	28-32	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	282-293
15881188-7	2005	Polyunsaturated fatty acids suppress SREBP-1c and suppress lipogenesis.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Homo sapiens	37-45
15850715-4	2005	Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance.	Fatty Acids, Unsaturated	11-38	insulin	Homo sapiens	145-152
15850715-4	2005	Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance.	Fatty Acids, Unsaturated	11-38	tumor necrosis factor	Homo sapiens	180-189
15850715-4	2005	Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance.	Fatty Acids, Unsaturated	11-38	macrophage migration inhibitory factor	Homo sapiens	197-235
15850715-4	2005	Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance.	Fatty Acids, Unsaturated	11-38	macrophage migration inhibitory factor	Homo sapiens	237-240
16187707-4	2005	Dietary PUFAs activate PPARalpha and PPARgamma increasing lipid oxidation, and decreasing insulin resistance leading in a reduction of hepatic steatosis.	Fatty Acids, Unsaturated	8-13	peroxisome proliferator activated receptor alpha	Homo sapiens	23-32
15850715-4	2005	Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance.	Fatty Acids, Unsaturated	11-38	solute carrier family 2 member 4	Homo sapiens	287-293
16187707-4	2005	Dietary PUFAs activate PPARalpha and PPARgamma increasing lipid oxidation, and decreasing insulin resistance leading in a reduction of hepatic steatosis.	Fatty Acids, Unsaturated	8-13	peroxisome proliferator activated receptor gamma	Homo sapiens	37-46
15850715-4	2005	Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance.	Fatty Acids, Unsaturated	11-38	insulin	Homo sapiens	145-152
15850717-6	2005	Administration of PUFAs induced higher levels of blood pressure; that of AA decreased serum TNFalpha and tissue bacterial load compared to controls.	Fatty Acids, Unsaturated	18-23	tumor necrosis factor	Homo sapiens	92-100
15766564-7	2005	These results demonstrate that EPA is an efficient substrate of CYP2C enzymes and suggest that n-3 PUFA-rich diets may shift the CYP2C-dependent generation of physiologically active eicosanoids from AA- to EPA-derived metabolites.	Fatty Acids, Unsaturated	99-103	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	64-69
15766564-7	2005	These results demonstrate that EPA is an efficient substrate of CYP2C enzymes and suggest that n-3 PUFA-rich diets may shift the CYP2C-dependent generation of physiologically active eicosanoids from AA- to EPA-derived metabolites.	Fatty Acids, Unsaturated	99-103	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	129-134
15655248-1	2005	Previously we demonstrated that supplementation with the polyunsaturated fatty acids (PUFA) arachidonic acid (AA) or docosahexaenoic acid (DHA) increased neurite outgrowth of PC12 cells during differentiation, and that overexpression of rat acyl-CoA synthetase long-chain family member 6 (Acsl6, formerly ACS2) further increased PUFA-enhanced neurite outgrowth.	Fatty Acids, Unsaturated	57-84	acyl-CoA synthetase long-chain family member 6	Rattus norvegicus	241-287
15797604-1	2005	The peroxidation of polyunsaturated fatty acids, common to all eukaryotes, is mostly catalyzed by members of the lipoxygenase enzyme family of non-heme iron containing dioxygenases.	Fatty Acids, Unsaturated	20-47	MTR_2g005920	Medicago truncatula	113-125
15655248-1	2005	Previously we demonstrated that supplementation with the polyunsaturated fatty acids (PUFA) arachidonic acid (AA) or docosahexaenoic acid (DHA) increased neurite outgrowth of PC12 cells during differentiation, and that overexpression of rat acyl-CoA synthetase long-chain family member 6 (Acsl6, formerly ACS2) further increased PUFA-enhanced neurite outgrowth.	Fatty Acids, Unsaturated	57-84	acyl-CoA synthetase long-chain family member 6	Rattus norvegicus	289-294
15655248-1	2005	Previously we demonstrated that supplementation with the polyunsaturated fatty acids (PUFA) arachidonic acid (AA) or docosahexaenoic acid (DHA) increased neurite outgrowth of PC12 cells during differentiation, and that overexpression of rat acyl-CoA synthetase long-chain family member 6 (Acsl6, formerly ACS2) further increased PUFA-enhanced neurite outgrowth.	Fatty Acids, Unsaturated	86-90	acyl-CoA synthetase long-chain family member 6	Rattus norvegicus	241-287
15655248-1	2005	Previously we demonstrated that supplementation with the polyunsaturated fatty acids (PUFA) arachidonic acid (AA) or docosahexaenoic acid (DHA) increased neurite outgrowth of PC12 cells during differentiation, and that overexpression of rat acyl-CoA synthetase long-chain family member 6 (Acsl6, formerly ACS2) further increased PUFA-enhanced neurite outgrowth.	Fatty Acids, Unsaturated	86-90	acyl-CoA synthetase long-chain family member 6	Rattus norvegicus	289-294
15740054-1	2005	Most of the volatile compounds responsible for the "green" notes to the aroma of fruits and vegetables are produced by the degradation of polyunsaturated fatty acids through the lipoxygenase pathway.	Fatty Acids, Unsaturated	138-165	probable linoleate 9S-lipoxygenase 5	Solanum tuberosum	178-190
15699360-2	2005	We have previously shown that the ratio of n-6 to n-3 polyunsaturated fatty acids (PUFA) in the maternal diet affects serum leptin levels and growth of the suckling pups.	Fatty Acids, Unsaturated	83-87	sugar efflux transporter SWEET16	Glycine max	50-53
15473864-10	2005	Taken together, these data suggest that PUFA can down-regulate hepatic cholesterol synthesis through inhibition of HMG-CoA reductase and FPP synthase, at least in part through impairment of the SREBP pathway.	Fatty Acids, Unsaturated	40-44	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	115-132
15767338-11	2005	Our data suggest that the XRCC1 codon 194 and codon 399 single nucleotide polymorphisms may modify the effect of unsaturated fatty acid and antioxidant intake and that this XRCC1 effect modification may explain, in part, previously reported inconsistencies on the role of unsaturated fatty acids and adenoma risk.	Fatty Acids, Unsaturated	113-135	X-ray repair cross complementing 1	Homo sapiens	26-31
15767338-11	2005	Our data suggest that the XRCC1 codon 194 and codon 399 single nucleotide polymorphisms may modify the effect of unsaturated fatty acid and antioxidant intake and that this XRCC1 effect modification may explain, in part, previously reported inconsistencies on the role of unsaturated fatty acids and adenoma risk.	Fatty Acids, Unsaturated	113-135	X-ray repair cross complementing 1	Homo sapiens	173-178
15767338-11	2005	Our data suggest that the XRCC1 codon 194 and codon 399 single nucleotide polymorphisms may modify the effect of unsaturated fatty acid and antioxidant intake and that this XRCC1 effect modification may explain, in part, previously reported inconsistencies on the role of unsaturated fatty acids and adenoma risk.	Fatty Acids, Unsaturated	272-295	X-ray repair cross complementing 1	Homo sapiens	26-31
15767338-11	2005	Our data suggest that the XRCC1 codon 194 and codon 399 single nucleotide polymorphisms may modify the effect of unsaturated fatty acid and antioxidant intake and that this XRCC1 effect modification may explain, in part, previously reported inconsistencies on the role of unsaturated fatty acids and adenoma risk.	Fatty Acids, Unsaturated	272-295	X-ray repair cross complementing 1	Homo sapiens	173-178
15735069-0	2005	Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Homo sapiens	46-51
15735069-0	2005	Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study.	Fatty Acids, Unsaturated	0-27	apolipoprotein C3	Homo sapiens	105-125
15767338-0	2005	XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk.	Fatty Acids, Unsaturated	68-91	X-ray repair cross complementing 1	Homo sapiens	0-5
15767338-0	2005	XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk.	Fatty Acids, Unsaturated	68-91	X-ray repair cross complementing 3	Homo sapiens	10-15
15686429-5	2005	Catalase activity in the muscle tissue increased as a consequence of the high-PUFA diet, which may indicate an increased demand caused by introduction of oxidative labile PUFA.	Fatty Acids, Unsaturated	78-82	catalase	Sus scrofa	0-8
15683247-8	2005	In a direct competition assay with palmitate, all the polyunsaturated fatty acids tested were strong competitors only for ACSL4 with IC50 values of 0.5 to 5 microM.	Fatty Acids, Unsaturated	54-81	acyl-CoA synthetase long-chain family member 4	Rattus norvegicus	122-127
15473864-10	2005	Taken together, these data suggest that PUFA can down-regulate hepatic cholesterol synthesis through inhibition of HMG-CoA reductase and FPP synthase, at least in part through impairment of the SREBP pathway.	Fatty Acids, Unsaturated	40-44	farnesyl diphosphate synthase	Rattus norvegicus	137-149
15607747-0	2005	Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats.	Fatty Acids, Unsaturated	8-35	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	52-80
15835259-1	2005	(1) This investigation studied the effects of dietary saturated and polyunsaturated fatty acids (PUFAs) from the n-3 and n-6 series on insulin action and glucose uptake in broiler chickens.	Fatty Acids, Unsaturated	97-102	insulin	Gallus gallus	135-142
15654818-1	2005	Our laboratory has demonstrated that down-regulation of proliferation and cytokine synthesis by CD4(+) T cells in mice fed diets rich in n-3 polyunsaturated fatty acids (PUFA) is highly dependent on the involvement of the co-stimulatory molecule, CD28.	Fatty Acids, Unsaturated	170-174	CD4 antigen	Mus musculus	96-99
15654818-1	2005	Our laboratory has demonstrated that down-regulation of proliferation and cytokine synthesis by CD4(+) T cells in mice fed diets rich in n-3 polyunsaturated fatty acids (PUFA) is highly dependent on the involvement of the co-stimulatory molecule, CD28.	Fatty Acids, Unsaturated	170-174	CD28 antigen	Mus musculus	247-251
15650559-7	2005	In addition, destabilization and decreased cellular surface expression of ABCA1 protein by unsaturated fatty acids have been identified.	Fatty Acids, Unsaturated	91-114	ATP binding cassette subfamily A member 1	Homo sapiens	74-79
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	interleukin 11	Mus musculus	120-125
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	interleukin 1 alpha	Mus musculus	226-235
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	interleukin 6	Mus musculus	237-241
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	interleukin 11	Mus musculus	243-248
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	mast cell protease 1	Mus musculus	250-255
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	mast cell protease 3	Mus musculus	257-262
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	chemokine (C-X-C motif) ligand 2	Mus musculus	264-269
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	fos-like antigen 2	Mus musculus	274-279
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	dual specificity phosphatase 1	Mus musculus	356-360
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	protein phosphatase 3, catalytic subunit, beta isoform	Mus musculus	365-372
15664096-3	2005	We have shown that unsaturated fatty acids and glucose upregulate NEP activity in human microvascular endothelial cells (HMECs) and that vitamins E and C reduce this effect.	Fatty Acids, Unsaturated	19-42	membrane metalloendopeptidase	Homo sapiens	66-69
15625711-3	2005	Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid that alters the synthesis of PGE2 and reduces the negative effects of TNF on body weight of healthy mice.	Fatty Acids, Unsaturated	36-62	tumor necrosis factor	Mus musculus	133-136
15607747-1	2005	Polyunsaturated fatty acids (PUFA) and a number of drugs (metformin, thiazolidinediones) and hormones (leptin, adiponectin) that activate AMP-activated protein kinase (AMPK) have been reported to improve insulin sensitivity.	Fatty Acids, Unsaturated	0-27	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	111-122
15607747-1	2005	Polyunsaturated fatty acids (PUFA) and a number of drugs (metformin, thiazolidinediones) and hormones (leptin, adiponectin) that activate AMP-activated protein kinase (AMPK) have been reported to improve insulin sensitivity.	Fatty Acids, Unsaturated	0-27	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	138-166
15607747-1	2005	Polyunsaturated fatty acids (PUFA) and a number of drugs (metformin, thiazolidinediones) and hormones (leptin, adiponectin) that activate AMP-activated protein kinase (AMPK) have been reported to improve insulin sensitivity.	Fatty Acids, Unsaturated	0-27	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	168-172
15607747-1	2005	Polyunsaturated fatty acids (PUFA) and a number of drugs (metformin, thiazolidinediones) and hormones (leptin, adiponectin) that activate AMP-activated protein kinase (AMPK) have been reported to improve insulin sensitivity.	Fatty Acids, Unsaturated	29-33	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	138-166
15607747-1	2005	Polyunsaturated fatty acids (PUFA) and a number of drugs (metformin, thiazolidinediones) and hormones (leptin, adiponectin) that activate AMP-activated protein kinase (AMPK) have been reported to improve insulin sensitivity.	Fatty Acids, Unsaturated	29-33	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	168-172
15489541-9	2005	In contrast, PLA(2)-LDL was more resistant to copper-mediated oxidation that was reversed upon the addition of small amounts of unsaturated fatty acids.	Fatty Acids, Unsaturated	128-151	phospholipase A2 group IB	Homo sapiens	13-19
15630029-1	2005	BACKGROUND: Consumption of polyunsaturated fatty acids (PUFAs) may reduce coronary heart disease (CHD) risk, but n-6 PUFAs may compete with n-3 PUFA metabolism and attenuate benefits.	Fatty Acids, Unsaturated	27-54	pumilio RNA binding family member 3	Homo sapiens	56-60
15585210-1	2005	BACKGROUND: The Jewish population of Israel consumes a diet rich in polyunsaturated fatty acids with a relatively low proportion of saturated fat, has a small alcohol intake and a lipid profile characterized by low HDL-cholesterol and high lipoprotein(a) (Lp(a)).	Fatty Acids, Unsaturated	68-95	lipoprotein(a)	Homo sapiens	240-254
15486012-3	2005	One particular member of the family, TREK-1 (also known as KCNK2), is activated by increasing temperature, membrane stretch and internal acidosis, but is also sensitive to the presence of certain polyunsaturated fatty acids (such as arachidonic acid), neuroprotectants (such as riluzole) and volatile and gaseous general anaesthetics (such as halothane and nitrous oxide).	Fatty Acids, Unsaturated	196-223	potassium two pore domain channel subfamily K member 2	Homo sapiens	37-43
15486012-3	2005	One particular member of the family, TREK-1 (also known as KCNK2), is activated by increasing temperature, membrane stretch and internal acidosis, but is also sensitive to the presence of certain polyunsaturated fatty acids (such as arachidonic acid), neuroprotectants (such as riluzole) and volatile and gaseous general anaesthetics (such as halothane and nitrous oxide).	Fatty Acids, Unsaturated	196-223	potassium two pore domain channel subfamily K member 2	Homo sapiens	59-64
15572846-8	2004	Since the 5-lipoxygenase pathway is abundantly expressed in atherosclerotic lesions, and 12/15-lipoxygenase is able to oxygenate polyunsaturated fatty acid esterified in the membranous phospholipids, 5-lipoxygenase or 12/15-lipoxygenase inhibitors may prevent progression of atherosclerosis.	Fatty Acids, Unsaturated	129-155	arachidonate 5-lipoxygenase	Homo sapiens	10-24
15331573-12	2004	This study clearly demonstrates that substitution of dietary polyunsaturated fatty acid for carbohydrate in the corpulent JCR:LA-cp rat reduces de novo lipogenesis, at least in part, by reducing hepatic expression of SREBP-1c and that strategies directed toward reducing SREBP-1c expression in the liver may mitigate the adverse effects of hyperinsulinemia on hepatic lipid production.	Fatty Acids, Unsaturated	61-87	sterol regulatory element binding transcription factor 1	Rattus norvegicus	217-225
15331573-12	2004	This study clearly demonstrates that substitution of dietary polyunsaturated fatty acid for carbohydrate in the corpulent JCR:LA-cp rat reduces de novo lipogenesis, at least in part, by reducing hepatic expression of SREBP-1c and that strategies directed toward reducing SREBP-1c expression in the liver may mitigate the adverse effects of hyperinsulinemia on hepatic lipid production.	Fatty Acids, Unsaturated	61-87	sterol regulatory element binding transcription factor 1	Rattus norvegicus	271-279
15572846-8	2004	Since the 5-lipoxygenase pathway is abundantly expressed in atherosclerotic lesions, and 12/15-lipoxygenase is able to oxygenate polyunsaturated fatty acid esterified in the membranous phospholipids, 5-lipoxygenase or 12/15-lipoxygenase inhibitors may prevent progression of atherosclerosis.	Fatty Acids, Unsaturated	129-155	arachidonate 15-lipoxygenase	Homo sapiens	89-107
15572846-8	2004	Since the 5-lipoxygenase pathway is abundantly expressed in atherosclerotic lesions, and 12/15-lipoxygenase is able to oxygenate polyunsaturated fatty acid esterified in the membranous phospholipids, 5-lipoxygenase or 12/15-lipoxygenase inhibitors may prevent progression of atherosclerosis.	Fatty Acids, Unsaturated	129-155	arachidonate 5-lipoxygenase	Homo sapiens	93-107
15572846-8	2004	Since the 5-lipoxygenase pathway is abundantly expressed in atherosclerotic lesions, and 12/15-lipoxygenase is able to oxygenate polyunsaturated fatty acid esterified in the membranous phospholipids, 5-lipoxygenase or 12/15-lipoxygenase inhibitors may prevent progression of atherosclerosis.	Fatty Acids, Unsaturated	129-155	arachidonate 15-lipoxygenase	Homo sapiens	218-236
15522828-11	2004	These results suggest that the transcription level of ACMSD is modulated by polyunsaturated fatty acids, and suppressive potency of ACMSD mRNA is n-3 fatty acid family&gt;linoleic acid (n-6 fatty acid)&gt;saturated fatty acid.	Fatty Acids, Unsaturated	76-103	aminocarboxymuconate semialdehyde decarboxylase	Rattus norvegicus	54-59
15522828-12	2004	Moreover, this study provides the information that a high polyunsaturated fatty acid diet affects the production of quinolinic acid in serum by suppressing the ACMSD activity.	Fatty Acids, Unsaturated	58-84	aminocarboxymuconate semialdehyde decarboxylase	Rattus norvegicus	160-165
15522828-11	2004	These results suggest that the transcription level of ACMSD is modulated by polyunsaturated fatty acids, and suppressive potency of ACMSD mRNA is n-3 fatty acid family&gt;linoleic acid (n-6 fatty acid)&gt;saturated fatty acid.	Fatty Acids, Unsaturated	76-103	aminocarboxymuconate semialdehyde decarboxylase	Rattus norvegicus	132-137
15726822-4	2004	Polyunsaturated fatty acids (PUFA), but not saturated or monounsaturated FA, suppress the induction of lipogenic genes by inhibiting the expression and processing of SREBP-1c.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Homo sapiens	166-174
15560787-0	2004	Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1beta-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids.	Fatty Acids, Unsaturated	143-170	cyclin D1	Rattus norvegicus	14-23
15560787-0	2004	Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1beta-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids.	Fatty Acids, Unsaturated	143-170	interleukin 1 beta	Rattus norvegicus	78-95
15726822-4	2004	Polyunsaturated fatty acids (PUFA), but not saturated or monounsaturated FA, suppress the induction of lipogenic genes by inhibiting the expression and processing of SREBP-1c.	Fatty Acids, Unsaturated	29-33	sterol regulatory element binding transcription factor 1	Homo sapiens	166-174
15726822-8	2004	Dietary PUFA, except for 18:2 n-6, are likely to induce FA oxidation enzymes via PPARalpha as a "feed-forward " mechanism.	Fatty Acids, Unsaturated	8-12	peroxisome proliferator activated receptor alpha	Homo sapiens	81-90
15491783-3	2004	In addition, TREK channels are sensitively activated by certain polyunsaturated fatty acids that have been shown to have neuroprotective activity and by volatile and gaseous general anaesthetics.	Fatty Acids, Unsaturated	64-91	potassium two pore domain channel subfamily K member 2	Homo sapiens	13-17
15491783-4	2004	New data derived from studies of knockout animals suggest that TREK-1 might have an important role in the general anaesthetic properties of volatile agents, such as halothane, and provide an explanation for the neuroprotective properties of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	241-268	potassium two pore domain channel subfamily K member 2	Homo sapiens	63-69
22900281-0	2004	Polyunsaturated fatty acids inhibit mouse hepatic glucocorticoid receptor activation in vitro.	Fatty Acids, Unsaturated	0-27	nuclear receptor subfamily 3, group C, member 1	Mus musculus	50-73
15294905-0	2004	Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells.	Fatty Acids, Unsaturated	181-208	glutathione peroxidase 7	Homo sapiens	35-114
15294905-0	2004	Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells.	Fatty Acids, Unsaturated	181-208	glutathione peroxidase 7	Homo sapiens	116-121
15294905-6	2004	Re-expression of NPGPx in breast cancer lines, MCF-7 and HCC1937, which have very little or no endogenous NPGPx, induced resistance to eicosapentaenoic acid (an omega-3 type of polyunsaturated fatty acid)-mediated cell death.	Fatty Acids, Unsaturated	177-203	glutathione peroxidase 7	Homo sapiens	17-22
15294905-8	2004	Thus, NPGPx plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism.	Fatty Acids, Unsaturated	106-132	glutathione peroxidase 7	Homo sapiens	6-11
15220333-0	2004	Regulation of unsaturated fatty acid biosynthesis in Saccharomyces: the endoplasmic reticulum membrane protein, Mga2p, a transcription activator of the OLE1 gene, regulates the stability of the OLE1 mRNA through exosome-mediated mechanisms.	Fatty Acids, Unsaturated	14-36	Mga2p	Saccharomyces cerevisiae S288C	112-117
15556291-1	2004	Stearoyl-CoA desaturase (SCD) is a rate-limiting enzyme in the biosynthesis of unsaturated fatty acids.	Fatty Acids, Unsaturated	79-102	stearoyl-CoA desaturase	Homo sapiens	0-23
15556291-1	2004	Stearoyl-CoA desaturase (SCD) is a rate-limiting enzyme in the biosynthesis of unsaturated fatty acids.	Fatty Acids, Unsaturated	79-102	stearoyl-CoA desaturase	Homo sapiens	25-28
15556291-9	2004	Comparison of different mammalian SCD promoters identified some regulatory domains required for the transcription regulation in the 5" flanking sequence of the porcine SCD gene, such as the conserved polyunsaturated fatty acid response region (PUFA-RE).	Fatty Acids, Unsaturated	200-226	stearoyl-CoA desaturase	Homo sapiens	34-37
15556291-9	2004	Comparison of different mammalian SCD promoters identified some regulatory domains required for the transcription regulation in the 5" flanking sequence of the porcine SCD gene, such as the conserved polyunsaturated fatty acid response region (PUFA-RE).	Fatty Acids, Unsaturated	200-226	stearoyl-CoA desaturase	Homo sapiens	168-171
15342124-5	2004	Our results suggest that uptake of lipoprotein-associated PC by the cerebrovasculature via SR-BI could generate a pool of lipids containing polyunsaturated fatty acids available for transport into deeper regions of the brain.	Fatty Acids, Unsaturated	140-167	scavenger receptor class B member 1	Cricetulus griseus	91-96
15351645-2	2004	This enzyme takes part in the beta-oxidation of unsaturated fatty acids by converting both cis-3 and trans-3-enoyl-CoA esters (with variable length of the acyl group) to trans-2-enoyl-CoA.	Fatty Acids, Unsaturated	48-71	suppressor of cytokine signaling 3	Homo sapiens	91-96
15220333-0	2004	Regulation of unsaturated fatty acid biosynthesis in Saccharomyces: the endoplasmic reticulum membrane protein, Mga2p, a transcription activator of the OLE1 gene, regulates the stability of the OLE1 mRNA through exosome-mediated mechanisms.	Fatty Acids, Unsaturated	14-36	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	152-156
15220333-0	2004	Regulation of unsaturated fatty acid biosynthesis in Saccharomyces: the endoplasmic reticulum membrane protein, Mga2p, a transcription activator of the OLE1 gene, regulates the stability of the OLE1 mRNA through exosome-mediated mechanisms.	Fatty Acids, Unsaturated	14-36	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	194-198
15220333-2	2004	In wild type cells grown on fatty acid-free medium, OLE1 mRNA has a half-life of 10 +/- 1.5 min (basal stability) that becomes highly unstable when cells are exposed to unsaturated fatty acids (regulated stability).	Fatty Acids, Unsaturated	169-192	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	52-56
15220333-6	2004	Mga2p appears to have two distinct functions with respect to the OLE1 mRNA stability: a stabilizing effect in cells grown in fatty acid-free medium and a destabilizing function in cells that are exposed to unsaturated fatty acids.	Fatty Acids, Unsaturated	206-229	Mga2p	Saccharomyces cerevisiae S288C	0-5
15325342-1	2004	The yolk sac membrane (YSM) of the chicken embryo is known to express delta-9 and delta-6 desaturase activities, suggesting that biosynthesis of the unsaturated fatty acids 18:1n-9, 20:4n-6 and 22:6n-3 might occur during the transfer of yolk lipids across the YSM.	Fatty Acids, Unsaturated	149-172	fatty acid desaturase 2	Gallus gallus	70-100
15190061-2	2004	Ligands for PPARgamma include some polyunsaturated fatty acids and prostanoids and the synthetic high affinity antidiabetic agents thiazolidinediones.	Fatty Acids, Unsaturated	35-62	peroxisome proliferator activated receptor gamma	Mus musculus	12-21
15307955-0	2004	Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets.	Fatty Acids, Unsaturated	0-27	nuclear receptor subfamily 1 group H member 4	Homo sapiens	32-35
15307955-0	2004	Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets.	Fatty Acids, Unsaturated	0-27	nuclear receptor subfamily 1 group H member 4	Homo sapiens	86-89
15307955-1	2004	Polyunsaturated fatty acids (PUFAs) have been previously reported as agonists of peroxisome proliferatoractivated receptor and antagonists of the liver X receptor.	Fatty Acids, Unsaturated	0-27	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	152-162
15307955-1	2004	Polyunsaturated fatty acids (PUFAs) have been previously reported as agonists of peroxisome proliferatoractivated receptor and antagonists of the liver X receptor.	Fatty Acids, Unsaturated	29-34	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	152-162
15284386-0	2004	Dietary polyunsaturated fatty acids modulate in vivo, antigen-driven CD4+ T-cell proliferation in mice.	Fatty Acids, Unsaturated	8-35	CD4 antigen	Mus musculus	69-72
15298681-6	2004	By gas chromatography-mass spectrometry analysis of triglyceride-associated fatty acids in the skin, saturated fatty acid palmitoic acid was decreased, whereas unsaturated fatty acids palmitoleic acid and oleic acid were increased in TNX-/- mice compared with those in wild-type mice.	Fatty Acids, Unsaturated	160-183	tenascin XB	Mus musculus	234-237
15298681-8	2004	An increase in the saturated fatty acid stearic acid and decreases in the unsaturated fatty acids palmitoleic acid, oleic acid and linoleic acid, compared to those in mock-transfected cells were also caused by over-expression of TNX.	Fatty Acids, Unsaturated	74-97	tenascin XB	Mus musculus	229-232
15310732-1	2004	Dietary polyunsaturated fatty acids (PUFA) have effects on diverse physiological processes impacting normal health and chronic diseases, such as the regulation of plasma lipid levels, cardiovascular and immune function, insulin action and neuronal development and visual function.	Fatty Acids, Unsaturated	8-35	insulin	Homo sapiens	220-227
15310732-1	2004	Dietary polyunsaturated fatty acids (PUFA) have effects on diverse physiological processes impacting normal health and chronic diseases, such as the regulation of plasma lipid levels, cardiovascular and immune function, insulin action and neuronal development and visual function.	Fatty Acids, Unsaturated	37-41	insulin	Homo sapiens	220-227
15254719-1	2004	Peroxisome proliferator activated receptor-gamma (PPARgamma) belongs to a family of nuclear receptors and acts as a receptor for peroxisome proliferators, steroids, retinoic acids and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	184-211	peroxisome proliferator activated receptor gamma	Homo sapiens	0-48
15254719-1	2004	Peroxisome proliferator activated receptor-gamma (PPARgamma) belongs to a family of nuclear receptors and acts as a receptor for peroxisome proliferators, steroids, retinoic acids and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	184-211	peroxisome proliferator activated receptor gamma	Homo sapiens	50-59
14967823-0	2004	LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1.	Fatty Acids, Unsaturated	72-95	nuclear receptor subfamily 1, group H, member 3	Mus musculus	0-3
15481543-1	2004	Gamma-linolenic acid (GLA, C18:3delta(6, 9, 12) is one of nutritionally important polyunsaturated fatty acids in human and animal diets.	Fatty Acids, Unsaturated	82-109	galactosidase alpha	Homo sapiens	22-25
15073272-0	2004	Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain.	Fatty Acids, Unsaturated	0-27	retinoid X receptor alpha	Mus musculus	87-112
15110148-7	2004	The effects of specific examples of modulators of the RyR, such as phosphorylation, metabolic changes, heart failure and polyunsaturated fatty acids, are discussed.	Fatty Acids, Unsaturated	121-148	ryanodine receptor 1	Homo sapiens	54-57
15084525-5	2004	Colonic caveolae in mice fed n-6 or n-3 PUFA enriched diets were characteristically enriched in cholesterol, sphingomyelin, and caveolin-1.	Fatty Acids, Unsaturated	40-44	caveolin 1, caveolae protein	Mus musculus	128-138
15138577-3	2004	We have assessed the role of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) on the enzymatic activity and protein expression of tumor-associated FAS in SK-Br3 human breast cancer cells, an experimental paradigm of FAS-overexpressing tumor cells in which FAS enzyme constitutes up to 28%, by weight, of the cytosolic proteins.	Fatty Acids, Unsaturated	78-83	fatty acid synthase	Homo sapiens	154-157
15142970-4	2004	PPARalpha is activated by polyunsaturated fatty acids and oxidized derivatives and by lipid-modifying drugs of the fibrate family, including fenofibrate or gemfibrozil.	Fatty Acids, Unsaturated	26-53	peroxisome proliferator activated receptor alpha	Homo sapiens	0-9
15142970-8	2004	Ligands for PPARbeta/delta are polyunsaturated fatty acids, prostaglandins, and synthetic compounds, some of which are presently in clinical development.	Fatty Acids, Unsaturated	31-58	peroxisome proliferator activated receptor delta	Homo sapiens	12-20
15263092-4	2004	In aged rats fed throughout life with PUFA-enriched diets, genes with altered expressions included transthyretin, alpha-synuclein, and calmodulins, which play important roles in synaptic plasticity and learning.	Fatty Acids, Unsaturated	38-42	synuclein alpha	Rattus norvegicus	114-129
15175651-7	2004	Neuroprotection by polyunsaturated fatty acids, which is impressive in Trek1+/+ mice, disappears in Trek1-/- mice indicating a central role of TREK-1 in this process.	Fatty Acids, Unsaturated	19-46	potassium channel, subfamily K, member 2	Mus musculus	71-76
15175651-7	2004	Neuroprotection by polyunsaturated fatty acids, which is impressive in Trek1+/+ mice, disappears in Trek1-/- mice indicating a central role of TREK-1 in this process.	Fatty Acids, Unsaturated	19-46	potassium channel, subfamily K, member 2	Mus musculus	100-105
15175651-7	2004	Neuroprotection by polyunsaturated fatty acids, which is impressive in Trek1+/+ mice, disappears in Trek1-/- mice indicating a central role of TREK-1 in this process.	Fatty Acids, Unsaturated	19-46	potassium channel, subfamily K, member 2	Mus musculus	143-149
15180607-0	2004	Relationship of erythrocyte membrane polyunsaturated fatty acids and prostate-specific antigen levels in Jamaican men.	Fatty Acids, Unsaturated	37-64	kallikrein related peptidase 3	Homo sapiens	69-94
15180607-1	2004	OBJECTIVE: To investigate the relationship between erythrocyte membrane polyunsaturated fatty acid (PUFA) and serum prostate- specific antigen (PSA) levels in Jamaican men, as there may be an association between prostate cancer incidence and dietary fatty acids, and prostate cancer incidence in Jamaica is among the highest in the world.	Fatty Acids, Unsaturated	72-98	kallikrein related peptidase 3	Homo sapiens	116-148
15180607-1	2004	OBJECTIVE: To investigate the relationship between erythrocyte membrane polyunsaturated fatty acid (PUFA) and serum prostate- specific antigen (PSA) levels in Jamaican men, as there may be an association between prostate cancer incidence and dietary fatty acids, and prostate cancer incidence in Jamaica is among the highest in the world.	Fatty Acids, Unsaturated	100-104	kallikrein related peptidase 3	Homo sapiens	116-148
14967823-0	2004	LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1.	Fatty Acids, Unsaturated	72-95	stearoyl-CoA desaturase	Homo sapiens	38-61
14967823-0	2004	LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1.	Fatty Acids, Unsaturated	72-95	ATP binding cassette subfamily A member 1	Homo sapiens	113-118
15971598-5	2004	delta6-fatty acid desaturase is the rate-limiting enzyme for the biosynthesis of PUFAs, which catalyses the conversion of linoleic acid and alpha-linolenic acid to gamma-linolenic acid and stearidonic acid respectively.	Fatty Acids, Unsaturated	81-86	fatty acid desaturase 2	Homo sapiens	0-28
14757164-0	2004	Inhibition of plasmin-mediated prostromelysin-1 activation by interaction of long chain unsaturated fatty acids with kringle 5.	Fatty Acids, Unsaturated	88-111	plasminogen	Homo sapiens	14-21
15094063-1	2004	This study was conducted on human Jurkat T-cells to investigate the role of depletion of intracellular Ca(2+) stores in the phosphorylation of two mitogen-activated protein kinases (MAPKs), i.e. extracellular signal-regulated kinase (ERK) 1 and ERK2, and their modulation by a polyunsaturated fatty acid, docosahexaenoic acid (DHA).	Fatty Acids, Unsaturated	277-303	mitogen-activated protein kinase 1	Homo sapiens	195-240
14966134-0	2004	Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.	Fatty Acids, Unsaturated	35-61	toll like receptor 6	Homo sapiens	107-132
15219460-0	2004	Impact of polyunsaturated fatty acids on cytoskeletal linkage of L-selectin.	Fatty Acids, Unsaturated	10-37	selectin L	Homo sapiens	65-75
14977874-0	2004	A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension.	Fatty Acids, Unsaturated	18-44	stearoyl-CoA desaturase	Rattus norvegicus	117-142
14977874-1	2004	Polyunsaturated fatty acids (PUFA) are known to repress SCD-1 gene expression, key enzyme of monounsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	0-27	stearoyl-CoA desaturase	Rattus norvegicus	56-61
14977874-1	2004	Polyunsaturated fatty acids (PUFA) are known to repress SCD-1 gene expression, key enzyme of monounsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	29-33	stearoyl-CoA desaturase	Rattus norvegicus	56-61
14977874-9	2004	These data provided evidence that the tested hypotensive PUFA combination reverses the high monounsaturated/saturated fatty acids ratio associated to hypertension in SHR, via a regulation monounsaturated fatty acid relative abundance by repression of SCD-1 gene.	Fatty Acids, Unsaturated	57-61	stearoyl-CoA desaturase	Rattus norvegicus	251-256
14729856-2	2004	Moreover, we estimated the diabetes risk and examined gene-nutrient interactions between these variants and the ratio of polyunsaturated fatty acid to saturated fat (SFA) in determining body mass index (BMI) and fasting insulin.	Fatty Acids, Unsaturated	121-147	insulin	Homo sapiens	220-227
15209096-5	2004	Cytochrome c release from brain CL liposomes was higher compared to heart CL, consistent with lower polyunsaturated fatty acid content.	Fatty Acids, Unsaturated	100-126	cytochrome c, somatic	Homo sapiens	0-12
14757164-6	2004	Taken together, these data indicate that inhibition of plasmin-induced proMMP-3 activation by unsaturated fatty acids was mediated through their preferential binding to kringle 5.	Fatty Acids, Unsaturated	94-117	plasminogen	Homo sapiens	55-62
14757164-11	2004	In conclusion, unsaturated fatty acids or molecules with similar structures could be attractive target for the development of natural pharmacological inhibitors directed against plasmin and/or MMPs in different pathological contexts such, skin UV irradiation, vascular diseases and tumour growth and invasion.	Fatty Acids, Unsaturated	15-38	plasminogen	Homo sapiens	178-185
15166803-7	2004	Highly unsaturated fatty acid activation of peroxisome proliferator-activated receptor alpha combined with their displacement of the oxysterol from liver receptor X may "trap" liver receptor X as transcriptionally inactive peroxisome proliferator-activated receptor alpha/liver receptor X heterodimer.	Fatty Acids, Unsaturated	7-29	peroxisome proliferator activated receptor alpha	Homo sapiens	44-92
15166803-7	2004	Highly unsaturated fatty acid activation of peroxisome proliferator-activated receptor alpha combined with their displacement of the oxysterol from liver receptor X may "trap" liver receptor X as transcriptionally inactive peroxisome proliferator-activated receptor alpha/liver receptor X heterodimer.	Fatty Acids, Unsaturated	7-29	peroxisome proliferator activated receptor alpha	Homo sapiens	223-271
14749737-0	2004	Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-beta to prevent human essential hypertension.	Fatty Acids, Unsaturated	11-38	transforming growth factor beta 1	Homo sapiens	89-120
14749284-3	2004	Activation is associated with a redistribution of the enzyme within the cell; activation of cPLA(2) generates arachidonic acid (AA), a biologically active unsaturated fatty acid that can be further metabolized to generate a plethora of biologically active molecules.	Fatty Acids, Unsaturated	155-177	phospholipase A2 group IVA	Homo sapiens	92-98
14603525-2	2004	We have analyzed the effect of aldehydes derived from peroxidation of polyunsaturated fatty acids on TF expression in human vascular smooth muscle cells (HVSMC).	Fatty Acids, Unsaturated	70-97	coagulation factor III, tissue factor	Homo sapiens	101-103
14767997-7	2004	Similar to menadione, the polyunsaturated fatty acid (PUFA) arachidonic acid (AA) induced an increased activation of ERK1/2 in hepatocytes that overexpressed CYP2E1.	Fatty Acids, Unsaturated	26-52	mitogen-activated protein kinase 3	Homo sapiens	117-123
14767997-7	2004	Similar to menadione, the polyunsaturated fatty acid (PUFA) arachidonic acid (AA) induced an increased activation of ERK1/2 in hepatocytes that overexpressed CYP2E1.	Fatty Acids, Unsaturated	26-52	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	158-164
14767997-7	2004	Similar to menadione, the polyunsaturated fatty acid (PUFA) arachidonic acid (AA) induced an increased activation of ERK1/2 in hepatocytes that overexpressed CYP2E1.	Fatty Acids, Unsaturated	54-58	mitogen-activated protein kinase 3	Homo sapiens	117-123
14767997-7	2004	Similar to menadione, the polyunsaturated fatty acid (PUFA) arachidonic acid (AA) induced an increased activation of ERK1/2 in hepatocytes that overexpressed CYP2E1.	Fatty Acids, Unsaturated	54-58	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	158-164
14767997-8	2004	However, CYP2E1-overexpressing cells were sensitized to necrotic death from AA and the PUFA gamma-linolenic acid, but not from saturated or monounsaturated fatty acids.	Fatty Acids, Unsaturated	87-91	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	9-15
14748719-2	2004	This Delta6-desaturase plays a major role in the biosynthesis of PUFAs (polyunsaturated fatty acids).	Fatty Acids, Unsaturated	65-70	fatty acid desaturase 2	Homo sapiens	11-22
14748719-2	2004	This Delta6-desaturase plays a major role in the biosynthesis of PUFAs (polyunsaturated fatty acids).	Fatty Acids, Unsaturated	72-99	fatty acid desaturase 2	Homo sapiens	11-22
14744237-2	2004	Ethanol, polyunsaturated fatty acids, and iron were found to be cytotoxic in HepG2 cells that overexpress CYP2E1.	Fatty Acids, Unsaturated	9-36	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	106-112
14962692-8	2004	Despite the beneficial effects on serum lipids, the PUFA diet led to the highest levels of myocardial lipoperoxide and lipid hydroperoxide and diminished superoxide dismutase and catalase activities.	Fatty Acids, Unsaturated	52-56	catalase	Rattus norvegicus	179-187
15142659-2	2004	Long chain acyl-CoA dehydrogenase (LCAD) has recently been shown to be the mitochondrial enzyme responsible for the beta-oxidation of branched chain and unsaturated fatty acids [Biochim.	Fatty Acids, Unsaturated	153-176	acyl-CoA dehydrogenase long chain	Homo sapiens	0-33
14753366-2	2004	Insulin increased SCD mRNA levels (P = 0.008) and synthesis of both saturated (P = 0.07) and unsaturated (P &lt; 0.001) fatty acids but had the greatest effect on unsaturated fatty acid synthesis, resulting in the overall production of a greater (P &lt; 0.001) proportion of monounsaturated fat.	Fatty Acids, Unsaturated	163-185	LOC105613195	Ovis aries	0-7
14563830-1	2004	The Delta6-desaturase catalyzes key steps in long-chain polyunsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	56-82	fatty acid desaturase 2	Rattus norvegicus	10-21
14667942-0	2004	Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7.	Fatty Acids, Unsaturated	14-37	beta-1,3-glucuronyltransferase 2	Homo sapiens	69-97
14667942-0	2004	Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7.	Fatty Acids, Unsaturated	14-37	beta-1,3-glucuronyltransferase 2	Homo sapiens	99-102
14667942-0	2004	Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7.	Fatty Acids, Unsaturated	14-37	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	176-182
14667942-0	2004	Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7.	Fatty Acids, Unsaturated	14-37	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	187-193
15142659-2	2004	Long chain acyl-CoA dehydrogenase (LCAD) has recently been shown to be the mitochondrial enzyme responsible for the beta-oxidation of branched chain and unsaturated fatty acids [Biochim.	Fatty Acids, Unsaturated	153-176	acyl-CoA dehydrogenase long chain	Homo sapiens	35-39
14647064-0	2003	Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Mus musculus	74-81
14647064-2	2003	Polyunsaturated fatty acids (PUFAs) are not only ligands for peroxisome proliferator-activated receptor (PPAR) alpha but are also negative regulators of hepatic lipogenesis, which is thought to be mediated by the repression of sterol regulatory element-binding protein (SREBP)-1.	Fatty Acids, Unsaturated	29-34	peroxisome proliferator activated receptor alpha	Mus musculus	61-103
14647064-2	2003	Polyunsaturated fatty acids (PUFAs) are not only ligands for peroxisome proliferator-activated receptor (PPAR) alpha but are also negative regulators of hepatic lipogenesis, which is thought to be mediated by the repression of sterol regulatory element-binding protein (SREBP)-1.	Fatty Acids, Unsaturated	29-34	peroxisome proliferator activated receptor alpha	Mus musculus	105-109
14647064-2	2003	Polyunsaturated fatty acids (PUFAs) are not only ligands for peroxisome proliferator-activated receptor (PPAR) alpha but are also negative regulators of hepatic lipogenesis, which is thought to be mediated by the repression of sterol regulatory element-binding protein (SREBP)-1.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Mus musculus	61-103
14647064-2	2003	Polyunsaturated fatty acids (PUFAs) are not only ligands for peroxisome proliferator-activated receptor (PPAR) alpha but are also negative regulators of hepatic lipogenesis, which is thought to be mediated by the repression of sterol regulatory element-binding protein (SREBP)-1.	Fatty Acids, Unsaturated	29-34	sterol regulatory element binding transcription factor 1	Mus musculus	227-278
14647064-2	2003	Polyunsaturated fatty acids (PUFAs) are not only ligands for peroxisome proliferator-activated receptor (PPAR) alpha but are also negative regulators of hepatic lipogenesis, which is thought to be mediated by the repression of sterol regulatory element-binding protein (SREBP)-1.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Mus musculus	105-109
14647064-2	2003	Polyunsaturated fatty acids (PUFAs) are not only ligands for peroxisome proliferator-activated receptor (PPAR) alpha but are also negative regulators of hepatic lipogenesis, which is thought to be mediated by the repression of sterol regulatory element-binding protein (SREBP)-1.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Mus musculus	227-278
12951357-1	2003	Fatty acid delta-6-desaturase (FADS2) is the rate-limiting enzyme in mammalian synthesis of long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	103-130	fatty acid desaturase 2	Homo sapiens	11-29
12951357-1	2003	Fatty acid delta-6-desaturase (FADS2) is the rate-limiting enzyme in mammalian synthesis of long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	103-130	fatty acid desaturase 2	Homo sapiens	31-36
12947098-1	2003	The Saccharomyces cerevisiae OLE1 gene encodes a membrane-bound Delta-9 fatty acid desaturase, whose expression is regulated by unsaturated fatty acids through both transcriptional and mRNA stability controls.	Fatty Acids, Unsaturated	128-151	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	29-33
14623501-3	2003	Expanding upon Horrobin"s theory that changes in brain size and in neural microconnectivity came about as a result of changes in dietary fat and phospholipid incorporation of highly unsaturated fatty acids, we propose a theory relating phospholipase A2 (PLA2) activity to the neuromodulatory effects of the noradrenergic system.	Fatty Acids, Unsaturated	182-205	phospholipase A2 group IB	Homo sapiens	236-252
14659696-3	2003	Several reactions mediate protein nitration, and all predominantly depend on z.rad;NO- and nitrite-dependent formation of nitrogen dioxide, a species capable of nitrating aromatic amino acids, nucleotides and unsaturated fatty acids.	Fatty Acids, Unsaturated	209-232	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	79-82
14646204-6	2003	Analysis of transcriptional expression showed that the levels of Le-FAD1 mRNA in the primordium and fruiting body of L. edodes were higher than in mycelia cultivated at 18 degrees C as well as 25 degrees C. These results correlated with the increase of unsaturated fatty acids (UFAs) in total lipids during fruiting-body formation.	Fatty Acids, Unsaturated	253-276	FMN adenylyltransferase	Saccharomyces cerevisiae S288C	68-72
14642773-3	2003	Polyunsaturated fatty acids (PUFA) are PPAR ligands and fatty acids are produced via TGH activity, so we studied whether dietary fats and PPAR agonists could regulate TGH expression.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Mus musculus	39-43
14642773-3	2003	Polyunsaturated fatty acids (PUFA) are PPAR ligands and fatty acids are produced via TGH activity, so we studied whether dietary fats and PPAR agonists could regulate TGH expression.	Fatty Acids, Unsaturated	29-33	peroxisome proliferator activated receptor alpha	Mus musculus	39-43
14642406-3	2003	We investigated the relative positive and negative effects of specific polyunsaturated fatty acids (PUFAs) and inflammatory cytokines on the activity and gene expression of the selenium-dependant redox enzyme GPx4.	Fatty Acids, Unsaturated	71-98	glutathione peroxidase 4	Homo sapiens	209-213
14642406-3	2003	We investigated the relative positive and negative effects of specific polyunsaturated fatty acids (PUFAs) and inflammatory cytokines on the activity and gene expression of the selenium-dependant redox enzyme GPx4.	Fatty Acids, Unsaturated	100-105	glutathione peroxidase 4	Homo sapiens	209-213
14646204-6	2003	Analysis of transcriptional expression showed that the levels of Le-FAD1 mRNA in the primordium and fruiting body of L. edodes were higher than in mycelia cultivated at 18 degrees C as well as 25 degrees C. These results correlated with the increase of unsaturated fatty acids (UFAs) in total lipids during fruiting-body formation.	Fatty Acids, Unsaturated	278-282	FMN adenylyltransferase	Saccharomyces cerevisiae S288C	68-72
12917410-2	2003	Studies with human embryonic kidney 293 cells indicate that unsaturated fatty acids interfere with oxysterols binding to LXR and antagonize oxysterol-induced LXRalpha activity.	Fatty Acids, Unsaturated	60-83	nuclear receptor subfamily 1 group H member 3	Homo sapiens	158-166
14578429-5	2003	RESULTS: Treatment of hRVE cells with the n6 polyunsaturated fatty acids (PUFAs) 18:2n6 and 20:4n6 for up to 24 hours resulted in a significant induction of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 protein levels.	Fatty Acids, Unsaturated	74-79	intercellular adhesion molecule 1	Homo sapiens	157-197
14578429-5	2003	RESULTS: Treatment of hRVE cells with the n6 polyunsaturated fatty acids (PUFAs) 18:2n6 and 20:4n6 for up to 24 hours resulted in a significant induction of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 protein levels.	Fatty Acids, Unsaturated	74-79	vascular cell adhesion molecule 1	Homo sapiens	202-242
12917410-13	2003	The unsaturated fatty acid suppression of SREBP-1 and its targeted lipogenic genes is independent of LXRalpha	Fatty Acids, Unsaturated	4-26	sterol regulatory element binding transcription factor 1	Rattus norvegicus	42-49
12866036-1	2003	Peroxisome-proliferator activated receptor-gamma (PPARgamma) belongs to a family of nuclear receptors and acts as receptor for peroxisome-proliferators, steroids, retinoic acids, and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	183-210	peroxisome proliferator activated receptor gamma	Homo sapiens	0-48
14594230-3	2003	Ten cows were selected that tested higher (n = 5) or lower (n = 5) in their proportion of milk unsaturated fatty acids.	Fatty Acids, Unsaturated	95-118	Weaning weight-maternal milk	Bos taurus	90-94
12853447-0	2003	Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha activity in rat primary hepatocytes.	Fatty Acids, Unsaturated	0-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	37-85
14669966-8	2003	The increased FA oxidation after n-3 PUFA supplementation of the high-fat diet was accompanied by lower plasma leptin concentration (-38%, P &lt; 0.05) and leptin mRNA expression (-66%, P &lt; 0.05) in retroperitoneal adipose tissue, and elevated hepatic mRNA level for the leptin receptor Ob-Ra (140%, P &lt; 0.05).	Fatty Acids, Unsaturated	37-41	leptin	Rattus norvegicus	111-117
14669966-8	2003	The increased FA oxidation after n-3 PUFA supplementation of the high-fat diet was accompanied by lower plasma leptin concentration (-38%, P &lt; 0.05) and leptin mRNA expression (-66%, P &lt; 0.05) in retroperitoneal adipose tissue, and elevated hepatic mRNA level for the leptin receptor Ob-Ra (140%, P &lt; 0.05).	Fatty Acids, Unsaturated	37-41	leptin	Rattus norvegicus	156-162
14669966-8	2003	The increased FA oxidation after n-3 PUFA supplementation of the high-fat diet was accompanied by lower plasma leptin concentration (-38%, P &lt; 0.05) and leptin mRNA expression (-66%, P &lt; 0.05) in retroperitoneal adipose tissue, and elevated hepatic mRNA level for the leptin receptor Ob-Ra (140%, P &lt; 0.05).	Fatty Acids, Unsaturated	37-41	leptin receptor	Rattus norvegicus	274-289
14507997-9	2003	sfd4 is a mutation in the FAD6 gene that encodes a plastidic omega6-desaturase that is involved in the synthesis of polyunsaturated fatty acid-containing lipids.	Fatty Acids, Unsaturated	116-142	fatty acid desaturase 6	Arabidopsis thaliana	26-30
12866036-1	2003	Peroxisome-proliferator activated receptor-gamma (PPARgamma) belongs to a family of nuclear receptors and acts as receptor for peroxisome-proliferators, steroids, retinoic acids, and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	183-210	peroxisome proliferator activated receptor gamma	Homo sapiens	50-59
12963475-6	2003	Two endogenous oxidized unsaturated fatty acids, (+/-)4-hydroxy-5E,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid (4-HDoHE) and (+/-)5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HETE) lactone, were very efficiently lactonized and hydrolyzed, respectively, by PON1.	Fatty Acids, Unsaturated	24-47	paraoxonase 1	Homo sapiens	256-260
14666695-0	2003	Polyunsaturated fatty acids induce cell death in YAC-1 lymphoma by a caspase-3-independent mechanism.	Fatty Acids, Unsaturated	0-27	ADP-ribosyltransferase 1	Mus musculus	49-54
14666695-0	2003	Polyunsaturated fatty acids induce cell death in YAC-1 lymphoma by a caspase-3-independent mechanism.	Fatty Acids, Unsaturated	0-27	caspase 3	Mus musculus	69-78
14666695-8	2003	CONCLUSION: On the basis of these results, we can speculate that long-chain polyunsaturated fatty acids such as EPA and AA as well as LNA induce cell death in YAC-1 lymphoma by an independent mechanism of caspase-3 activation.	Fatty Acids, Unsaturated	76-103	ADP-ribosyltransferase 1	Mus musculus	159-164
13129455-7	2003	Results also showed that polyunsaturated FA inhibit the ADD1 expression, not only of mRNA concentration, but also of mature ADD1 protein concentration, suggesting an overall reduction of ADD1 function by polyunsaturated FA.	Fatty Acids, Unsaturated	25-43	adducin 1	Homo sapiens	56-60
14666695-8	2003	CONCLUSION: On the basis of these results, we can speculate that long-chain polyunsaturated fatty acids such as EPA and AA as well as LNA induce cell death in YAC-1 lymphoma by an independent mechanism of caspase-3 activation.	Fatty Acids, Unsaturated	76-103	caspase 3	Mus musculus	205-214
12724278-0	2003	Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells.	Fatty Acids, Unsaturated	0-27	prostaglandin-endoperoxide synthase 2	Bos taurus	137-174
12724278-0	2003	Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells.	Fatty Acids, Unsaturated	0-27	LOC104974671	Bos taurus	179-195
13129455-7	2003	Results also showed that polyunsaturated FA inhibit the ADD1 expression, not only of mRNA concentration, but also of mature ADD1 protein concentration, suggesting an overall reduction of ADD1 function by polyunsaturated FA.	Fatty Acids, Unsaturated	25-43	adducin 1	Homo sapiens	124-128
13129455-7	2003	Results also showed that polyunsaturated FA inhibit the ADD1 expression, not only of mRNA concentration, but also of mature ADD1 protein concentration, suggesting an overall reduction of ADD1 function by polyunsaturated FA.	Fatty Acids, Unsaturated	25-43	adducin 1	Homo sapiens	124-128
13129455-7	2003	Results also showed that polyunsaturated FA inhibit the ADD1 expression, not only of mRNA concentration, but also of mature ADD1 protein concentration, suggesting an overall reduction of ADD1 function by polyunsaturated FA.	Fatty Acids, Unsaturated	204-222	adducin 1	Homo sapiens	56-60
12807874-12	2003	In view of its ability to reduce short-chain aldehydes in addition to retinals, we propose that SCALD may be induced by SREBP in liver and other tissues to prevent toxicity from fatty aldehydes that are generated from oxidation of unsaturated fatty acids that are synthesized as a result of SREBP activity.	Fatty Acids, Unsaturated	231-254	retinol dehydrogenase 11	Mus musculus	96-101
12851727-1	2003	Highly unsaturated fatty acids (HUFAs) are cyto-toxic to cancer cells and generated in the body by desaturation from essential fatty acids, primarily involving delta-6-desaturase.	Fatty Acids, Unsaturated	7-30	fatty acid desaturase 2	Homo sapiens	160-178
12838507-0	2003	Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure.	Fatty Acids, Unsaturated	114-140	glucose-6-phosphate dehydrogenase	Rattus norvegicus	19-52
12767456-2	2003	It is proposed that long-chain polyunsaturated fatty acids when given from the perinatal period will ensure proper development and growth of the brain and maintain the activity and/or concentrations of ras, nitric oxide, insulin, and various neurotransmitters and cytokines at physiological level and thus, improve memory and prevent learning deficits.	Fatty Acids, Unsaturated	31-58	insulin	Homo sapiens	221-228
12892996-1	2003	The oxidation of polyunsaturated fatty acids results in the production of HNE, which can react through both non-enzymatic and enzyme catalyzed reactions to modify a number of cellular components, including proteins and DNA.	Fatty Acids, Unsaturated	17-44	elastase, neutrophil expressed	Homo sapiens	74-77
12839499-8	2003	Deletion of RSP5 blocks mRNA export, even under conditions where its essential role in unsaturated fatty acids biosynthesis is bypassed.	Fatty Acids, Unsaturated	87-110	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	12-16
12957295-14	2003	These results support the suggestion that low concentrations of iron and polyunsaturated fatty acids can act as priming or sensitizing factors for CYP2E1-induced injury in HepG2 cells and hepatocytes.	Fatty Acids, Unsaturated	73-100	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	147-153
12826254-0	2003	Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. With the combined techniques of on-line liquid chromatography/electron spin resonance (LC/ESR) and on-line liquid chromatography/mass spectrometry (LC/MS), we have previously characterized all classes of lipid-derived carbon-centered radicals (*Ld) formed from omega-6 polyunsaturated fatty acids (PUFAs: linoleic acid and arachidonic acid).	Fatty Acids, Unsaturated	474-479	linoleate 9S-lipoxygenase-4	Glycine max	67-79
12872970-0	2003	Polyunsaturated fatty acids reduce insulin and very low density lipoprotein levels in broiler chickens.	Fatty Acids, Unsaturated	0-27	insulin	Gallus gallus	35-42
12763030-3	2003	Polyunsaturated fatty acids, known to activate peroxisome proliferator-activated receptor (PPAR), have been reported to increase hepatic cholesterol uptake.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Homo sapiens	47-89
12763030-3	2003	Polyunsaturated fatty acids, known to activate peroxisome proliferator-activated receptor (PPAR), have been reported to increase hepatic cholesterol uptake.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Homo sapiens	91-95
12733060-2	2003	Transcription of the OLE1 gene is repressed by unsaturated fatty acids (UFAs) and activated by hypoxia and low temperatures via the endoplasmic reticulum membrane protein Mga2p.	Fatty Acids, Unsaturated	47-70	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	21-25
12771323-5	2003	The plasma concentrations of apo A-IV increased when subjects consumed the diets rich in unsaturated fatty acids, by 16% or 13.0 mg/L [F((2,76)) = 12.874, P &lt; 0.001 by repeated-measures ANOVA].	Fatty Acids, Unsaturated	89-112	apolipoprotein A4	Homo sapiens	29-37
12771323-7	2003	In conclusion, diets rich in unsaturated fatty acids, independent of the degree of unsaturation, gender and apo A-IV genotype, increase plasma apo A-IV concentrations compared with a baseline diet rich in SFA in healthy men and women.	Fatty Acids, Unsaturated	29-52	apolipoprotein A4	Homo sapiens	108-116
12771323-7	2003	In conclusion, diets rich in unsaturated fatty acids, independent of the degree of unsaturation, gender and apo A-IV genotype, increase plasma apo A-IV concentrations compared with a baseline diet rich in SFA in healthy men and women.	Fatty Acids, Unsaturated	29-52	apolipoprotein A4	Homo sapiens	143-151
12733060-2	2003	Transcription of the OLE1 gene is repressed by unsaturated fatty acids (UFAs) and activated by hypoxia and low temperatures via the endoplasmic reticulum membrane protein Mga2p.	Fatty Acids, Unsaturated	72-76	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	21-25
12733060-3	2003	We previously reported the isolation of the nfo3-1 (negative factor for OLE1) mutant, which exhibits enhanced expression of OLE1 in the presence of UFA and under aerobic conditions.	Fatty Acids, Unsaturated	148-151	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	72-76
12733060-3	2003	We previously reported the isolation of the nfo3-1 (negative factor for OLE1) mutant, which exhibits enhanced expression of OLE1 in the presence of UFA and under aerobic conditions.	Fatty Acids, Unsaturated	148-151	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	124-128
12733060-5	2003	The ratio of UFAs to total fatty acids in the ole1-101 mutant was 60%, compared to 75% in the wild type, suggesting that the reduction in relative levels of intracellular UFAs activates OLE1 transcription.	Fatty Acids, Unsaturated	13-17	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	46-50
12733060-5	2003	The ratio of UFAs to total fatty acids in the ole1-101 mutant was 60%, compared to 75% in the wild type, suggesting that the reduction in relative levels of intracellular UFAs activates OLE1 transcription.	Fatty Acids, Unsaturated	13-17	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	186-190
12733060-5	2003	The ratio of UFAs to total fatty acids in the ole1-101 mutant was 60%, compared to 75% in the wild type, suggesting that the reduction in relative levels of intracellular UFAs activates OLE1 transcription.	Fatty Acids, Unsaturated	171-175	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	46-50
12733060-5	2003	The ratio of UFAs to total fatty acids in the ole1-101 mutant was 60%, compared to 75% in the wild type, suggesting that the reduction in relative levels of intracellular UFAs activates OLE1 transcription.	Fatty Acids, Unsaturated	171-175	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	186-190
12733060-6	2003	However, in ole1-101 cells grown in the presence of oleic acid, the level of OLE1 expression remained high, although the relative amount of UFAs in the ole1-101 mutant cells was almost the same as that in wild-type cells growing under the same conditions.	Fatty Acids, Unsaturated	140-144	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	12-16
12733060-6	2003	However, in ole1-101 cells grown in the presence of oleic acid, the level of OLE1 expression remained high, although the relative amount of UFAs in the ole1-101 mutant cells was almost the same as that in wild-type cells growing under the same conditions.	Fatty Acids, Unsaturated	140-144	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	152-156
12733060-8	2003	These observations suggest that the ole1-101 cells activate OLE1 transcription by sensing not only the intracellular UFA level, but also membrane fluidity or the nature of the UFA species itself.	Fatty Acids, Unsaturated	117-120	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	36-40
12733060-8	2003	These observations suggest that the ole1-101 cells activate OLE1 transcription by sensing not only the intracellular UFA level, but also membrane fluidity or the nature of the UFA species itself.	Fatty Acids, Unsaturated	117-120	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	60-64
12733060-8	2003	These observations suggest that the ole1-101 cells activate OLE1 transcription by sensing not only the intracellular UFA level, but also membrane fluidity or the nature of the UFA species itself.	Fatty Acids, Unsaturated	176-179	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	36-40
12733060-8	2003	These observations suggest that the ole1-101 cells activate OLE1 transcription by sensing not only the intracellular UFA level, but also membrane fluidity or the nature of the UFA species itself.	Fatty Acids, Unsaturated	176-179	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	60-64
12752626-2	2003	Both processes affect the abundance of volatile organic compounds (VOCs) in the breath because oxidative stress causes lipid peroxidation of polyunsaturated fatty acids in membranes, producing alkanes and methylalkanes which are catabolized by CYP.	Fatty Acids, Unsaturated	141-168	peptidylprolyl isomerase G	Homo sapiens	244-247
12787479-0	2003	Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanism.	Fatty Acids, Unsaturated	46-73	fatty acid synthase	Rattus norvegicus	15-34
12713571-1	2003	Delta-6 desaturase, also known as fatty acid desaturase-2 (FADS2), is a component of a lipid metabolic pathway that converts the essential fatty acids linoleate and alpha-linolenate into long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	198-225	fatty acid desaturase 2	Homo sapiens	0-18
12765684-2	2003	Recent evidence is reviewed suggesting that Drosophila TRP channels are activated by one or more lipid products of PLC activity: namely diacylglycerol (DAG), its metabolites (polyunsaturated fatty acids) or the reduction in phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Fatty Acids, Unsaturated	175-202	Phospholipase C at 21C	Drosophila melanogaster	115-118
12713571-1	2003	Delta-6 desaturase, also known as fatty acid desaturase-2 (FADS2), is a component of a lipid metabolic pathway that converts the essential fatty acids linoleate and alpha-linolenate into long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	198-225	fatty acid desaturase 2	Homo sapiens	34-57
12713571-1	2003	Delta-6 desaturase, also known as fatty acid desaturase-2 (FADS2), is a component of a lipid metabolic pathway that converts the essential fatty acids linoleate and alpha-linolenate into long-chain polyunsaturated fatty acids.	Fatty Acids, Unsaturated	198-225	fatty acid desaturase 2	Homo sapiens	59-64
12713571-4	2003	Enzymatic analysis using CHO cells overexpressing human Delta-6 desaturase/FADS2 indicates catalysis of a "polyunsaturated fatty acid type" reaction, but also an unexpected "sebaceous-type" reaction, that of converting palmitate into the mono-unsaturated fatty acid sapienate, a 16-carbon fatty acid with a single cis double bond at the sixth carbon from the carboxyl end.	Fatty Acids, Unsaturated	107-133	fatty acid desaturase 2	Homo sapiens	56-74
12713571-4	2003	Enzymatic analysis using CHO cells overexpressing human Delta-6 desaturase/FADS2 indicates catalysis of a "polyunsaturated fatty acid type" reaction, but also an unexpected "sebaceous-type" reaction, that of converting palmitate into the mono-unsaturated fatty acid sapienate, a 16-carbon fatty acid with a single cis double bond at the sixth carbon from the carboxyl end.	Fatty Acids, Unsaturated	107-133	fatty acid desaturase 2	Homo sapiens	75-80
12713571-6	2003	This work identifies Delta-6 desaturase/FADS2 as the major fatty acid desaturase in human sebaceous glands and suggests that the environment of the sebaceous gland permits catalysis of the sebaceous-type reaction and restricts catalysis of the polyunsaturated fatty acid type reaction.	Fatty Acids, Unsaturated	244-270	fatty acid desaturase 2	Homo sapiens	21-39
12713571-6	2003	This work identifies Delta-6 desaturase/FADS2 as the major fatty acid desaturase in human sebaceous glands and suggests that the environment of the sebaceous gland permits catalysis of the sebaceous-type reaction and restricts catalysis of the polyunsaturated fatty acid type reaction.	Fatty Acids, Unsaturated	244-270	fatty acid desaturase 2	Homo sapiens	40-45
12612204-8	2003	A positive association was observed between TGF-beta2 and the proportion of polyunsaturated fatty acids (p = 0.038) and a negative association between TGF-beta2 and the proportion of saturated fatty acids (p = 0.029) in breast milk.	Fatty Acids, Unsaturated	76-103	transforming growth factor beta 2	Homo sapiens	44-53
12683809-6	2003	These observations are consistent with various experimental studies on rhodopsin and other G-protein coupled receptors and with the picture of extreme flexibility in polyunsaturated fatty acid chains that has arisen from recent NMR and computational work.	Fatty Acids, Unsaturated	166-192	rhodopsin	Homo sapiens	71-80
12569099-9	2003	Analysis of the activity of six additional synthetic and potentially endogenous N-acyldopamine indicated the requirement of a long unsaturated fatty acid chain for an optimal functional interaction with VR1 receptors.	Fatty Acids, Unsaturated	131-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	203-206
12746754-12	2003	In their study, fasting glucose, insulin and fasting chylomicrons and postprandial chylomicrons and VLDL were higher following the PUFA diet.	Fatty Acids, Unsaturated	131-135	insulin	Homo sapiens	33-40
12603834-7	2003	The resultant ALDH2-deficient transfectants were highly vulnerable to exogenous 4-hydroxy-2-nonenal, an aldehyde derivative generated by the reaction of superoxide with unsaturated fatty acid.	Fatty Acids, Unsaturated	169-191	aldehyde dehydrogenase 2 family member	Rattus norvegicus	14-19
12615663-7	2003	We demonstrated a PON1 phospholipase-A2-like activity on MPMs, evidenced by release of polyunsaturated fatty acids and formation of lysophosphatidylcholine.	Fatty Acids, Unsaturated	87-114	paraoxonase 1	Mus musculus	18-22
12615663-7	2003	We demonstrated a PON1 phospholipase-A2-like activity on MPMs, evidenced by release of polyunsaturated fatty acids and formation of lysophosphatidylcholine.	Fatty Acids, Unsaturated	87-114	phospholipase A2, group IB, pancreas	Mus musculus	23-39
12502717-6	2003	Electrospray ionization mass spectrometric analysis of membrane extracts revealed that overexpression of cPLA(2)gamma increased the proportion of polyunsaturated fatty acids in phosphatidylethanolamine, suggesting that the enzyme modulates the phospholipid composition.	Fatty Acids, Unsaturated	146-173	phospholipase A2 group IVC	Homo sapiens	105-117
12488438-2	2003	In adult animals, insulin and oxysterols induce SREBP-1c gene transcription, whereas polyunsaturated fatty acids suppress the nuclear content of SREBP-1c through pre-translational regulatory mechanisms.	Fatty Acids, Unsaturated	85-112	sterol regulatory element binding transcription factor 1	Rattus norvegicus	145-153
12573452-2	2003	We established that among fish oil polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), but not docosahexaenoic acid (DHA), greatly decreased interleukin-1beta (IL-1beta)-induced PGHS-2 expression in human pulmonary microvascular endothelial cells (HPMECs).	Fatty Acids, Unsaturated	35-62	interleukin 1 beta	Homo sapiens	174-182
12488335-2	2003	Unsaturated fatty acids, their derivatives, and fibrates activate PPARalpha.	Fatty Acids, Unsaturated	0-23	peroxisome proliferator activated receptor alpha	Rattus norvegicus	66-75
12618397-0	2003	Deficiencies in C20 polyunsaturated fatty acids cause behavioral and developmental defects in Caenorhabditis elegans fat-3 mutants.	Fatty Acids, Unsaturated	20-47	Delta(6)-fatty-acid desaturase fat-3;FA_desaturase domain-containing protein	Caenorhabditis elegans	117-122
12538077-0	2003	The role of cytochrome b5 fusion desaturases in the synthesis of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	65-92	cytochrome b5 type A	Homo sapiens	12-25
15206789-2	2003	We previously reported that ingestion of polyunsaturated fatty acids by rats leads to a decrease in their hepatic ACMSD activity.	Fatty Acids, Unsaturated	41-68	aminocarboxymuconate semialdehyde decarboxylase	Rattus norvegicus	114-119
12518029-5	2003	These results suggests that cPLA(2) is necessary to maintain normal brain concentrations of phospholipids and of their esterified polyunsaturated fatty acids.	Fatty Acids, Unsaturated	130-157	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	28-34
12586704-6	2003	RNAi-mediated suppression of ELO-2 causes an accumulation of palmitate and an associated decrease in the PUFA fraction in triacylglycerides and phospholipid classes.	Fatty Acids, Unsaturated	105-109	Elongation of long chain fatty acids protein 2	Caenorhabditis elegans	29-34
12652939-2	2003	Omega-3 polyunsaturated fatty acid (PUFA) drugs enhance the formation of autoantibodies to modified ADH and decrease the activity of ADH in the stomach and liver.	Fatty Acids, Unsaturated	8-34	aldo-keto reductase family 1 member A1	Rattus norvegicus	100-103
12652939-2	2003	Omega-3 polyunsaturated fatty acid (PUFA) drugs enhance the formation of autoantibodies to modified ADH and decrease the activity of ADH in the stomach and liver.	Fatty Acids, Unsaturated	8-34	aldo-keto reductase family 1 member A1	Rattus norvegicus	133-136
12652939-2	2003	Omega-3 polyunsaturated fatty acid (PUFA) drugs enhance the formation of autoantibodies to modified ADH and decrease the activity of ADH in the stomach and liver.	Fatty Acids, Unsaturated	36-40	aldo-keto reductase family 1 member A1	Rattus norvegicus	100-103
12652939-2	2003	Omega-3 polyunsaturated fatty acid (PUFA) drugs enhance the formation of autoantibodies to modified ADH and decrease the activity of ADH in the stomach and liver.	Fatty Acids, Unsaturated	36-40	aldo-keto reductase family 1 member A1	Rattus norvegicus	133-136
12213084-0	2002	Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Homo sapiens	55-98
12866356-3	2003	The known endogenous PPAR ligands are polyunsaturated fatty acids and eicosanoids, such as 15-deoxy-delta 12,14-prostaglandin J2 and leukotriene B4.	Fatty Acids, Unsaturated	38-65	peroxisome proliferator activated receptor alpha	Homo sapiens	21-25
14608614-1	2003	The binding property of parinaric acid, a polyunsaturated fatty acid, to bovine beta-lactoglobulin, has been studied by electrospray ionization mass spectrometry.	Fatty Acids, Unsaturated	42-68	beta-lactoglobulin	Bos taurus	80-98
12213084-11	2002	In CaCo-2 cells, polyunsaturated fatty acids decrease gene and protein expression of SREBP-1 and FAS mRNA, probably through interference with LXR activity.	Fatty Acids, Unsaturated	17-44	sterol regulatory element binding transcription factor 1	Homo sapiens	85-92
12213084-11	2002	In CaCo-2 cells, polyunsaturated fatty acids decrease gene and protein expression of SREBP-1 and FAS mRNA, probably through interference with LXR activity.	Fatty Acids, Unsaturated	17-44	fatty acid synthase	Homo sapiens	97-100
12553726-2	2002	The formation of S100A8/A9 protein complexes and the binding of calcium to the complexes are prerequisites for the specific binding of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	135-162	S100 calcium binding protein A8	Homo sapiens	17-23
12406560-4	2002	Unsaturated fatty acids also showed cytotoxicity against a SNU16 human stomach cancer cell line and conjugated linoleic acid suppressed mRNA expression of several myc-target genes; ornithine decarboxylase, p53, cdc25a in the SNU16 cells.	Fatty Acids, Unsaturated	0-23	ornithine decarboxylase 1	Homo sapiens	181-204
12406560-4	2002	Unsaturated fatty acids also showed cytotoxicity against a SNU16 human stomach cancer cell line and conjugated linoleic acid suppressed mRNA expression of several myc-target genes; ornithine decarboxylase, p53, cdc25a in the SNU16 cells.	Fatty Acids, Unsaturated	0-23	cell division cycle 25A	Homo sapiens	211-217
12419704-6	2002	Dietary restriction of unsaturated fatty acid decreased myocardial glycogen, and increased the lactate dehydrogenase/citrate synthase ratio.	Fatty Acids, Unsaturated	23-45	citrate synthase	Rattus norvegicus	117-133
12419306-6	2002	Our results demonstrate that DHA and other unsaturated fatty acids act as antagonists instead of agonists for transactivation of PPRE and PPAR-regulated gene expression in the cell lines tested.	Fatty Acids, Unsaturated	43-66	peroxisome proliferator activated receptor alpha	Homo sapiens	138-142
12440977-5	2002	The half-life of the OLE1 mRNA is also dramatically reduced upon exposure to unsaturated fatty acids.	Fatty Acids, Unsaturated	77-100	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	21-25
12440977-7	2002	Although proteolytic processing of Spt23p can be repressed by polyunsaturated fatty acids, Mga2p processing in normoxic cells appears to be regulated by a different mechanism.	Fatty Acids, Unsaturated	62-89	Spt23p	Saccharomyces cerevisiae S288C	35-41
12419843-1	2002	The stearoyl-CoA desaturase 1 (Scd1) gene is involved in the synthesis and regulation of unsaturated fatty acids.	Fatty Acids, Unsaturated	89-112	stearoyl-CoA desaturase	Rattus norvegicus	4-29
12421847-1	2002	Male Sprague-Dawley rats, trained to consume their daily energy needs in a single 3-h meal (0900-1200 h), were used to examine the hypothesis that polyunsaturated fatty acids (PUFA) lowered the nuclear content of sterol regulatory element binding protein (SREBP)-1 and/or -2 by suppressing the proteolytic release of mature SREBP from the membrane-anchored precursor pool.	Fatty Acids, Unsaturated	147-174	sterol regulatory element binding transcription factor 1	Rattus norvegicus	256-264
12419843-1	2002	The stearoyl-CoA desaturase 1 (Scd1) gene is involved in the synthesis and regulation of unsaturated fatty acids.	Fatty Acids, Unsaturated	89-112	stearoyl-CoA desaturase	Rattus norvegicus	31-35
12421842-1	2002	This study is the first to describe the impact of consuming a diet rich in (n-3) polyunsaturated fatty acids (PUFA) from fish oil on antigen-driven activation of naive CD4+ T lymphocytes.	Fatty Acids, Unsaturated	110-114	CD4 antigen	Mus musculus	168-171
12421847-2	2002	The nuclear concentrations of hepatic SREBP-1 and -2 were 50 and 42% lower (P &lt; 0.05) in rats that consumed a single PUFA-supplemented meal (i.e., 10 g fish oil/100 g fat-free diet) than in rats fed the fat-free diet alone.	Fatty Acids, Unsaturated	120-124	sterol regulatory element binding transcription factor 1	Rattus norvegicus	38-52
12363390-1	2002	Recently, apolipoprotein D (apoD), a protein that is involved in the essential polyunsaturated fatty acid (EPUFA) transport and metabolism, and neuronal growth and regeneration was reported to have increased in the postmortem brain and decreased in the serum of schizophrenia patients.	Fatty Acids, Unsaturated	79-105	apolipoprotein D	Homo sapiens	10-26
12363390-1	2002	Recently, apolipoprotein D (apoD), a protein that is involved in the essential polyunsaturated fatty acid (EPUFA) transport and metabolism, and neuronal growth and regeneration was reported to have increased in the postmortem brain and decreased in the serum of schizophrenia patients.	Fatty Acids, Unsaturated	79-105	apolipoprotein D	Homo sapiens	28-32
12351428-9	2002	Downregulation of ABCA1 by unsaturated fatty acids and acetoacetate may contribute to low HDL cholesterol and increased cardiovascular risk of diabetic patients.	Fatty Acids, Unsaturated	27-50	ATP binding cassette subfamily A member 1	Homo sapiens	18-23
12364560-4	2002	Previous in vivo studies have shown that the transcriptional repression by n-3 and n-6 polyunsaturated fatty acids (PUFAs) and the induction by cholesterol of the SCD1 gene are dependent on the maturation of the sterol regulatory element-binding protein-1c (SREBP-1c).	Fatty Acids, Unsaturated	116-121	sterol regulatory element binding transcription factor 1	Mus musculus	212-256
12351428-0	2002	Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1.	Fatty Acids, Unsaturated	0-27	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	80-115
12351428-5	2002	Incubation of cultivated HepG2 hepatocytes and RAW264.7 macrophages with unsaturated fatty acids or acetoacetate, but not with insulin, glucose, saturated fatty acids, or hydroxybutyrate, downregulated ABCA1 mRNA and protein.	Fatty Acids, Unsaturated	73-96	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	202-207
12351428-6	2002	The suppressive effect of unsaturated fatty acids and acetoacetate became most obvious in cells stimulated with oxysterols or retinoic acid but was independent of the expression of the thereby regulated transcription factors liver-X-receptor alpha (LXRalpha) and retinoid-X-receptor alpha (RXRalpha), respectively.	Fatty Acids, Unsaturated	26-49	nuclear receptor subfamily 1, group H, member 3	Mus musculus	249-257
12351428-6	2002	The suppressive effect of unsaturated fatty acids and acetoacetate became most obvious in cells stimulated with oxysterols or retinoic acid but was independent of the expression of the thereby regulated transcription factors liver-X-receptor alpha (LXRalpha) and retinoid-X-receptor alpha (RXRalpha), respectively.	Fatty Acids, Unsaturated	26-49	retinoid X receptor alpha	Mus musculus	263-288
12351428-6	2002	The suppressive effect of unsaturated fatty acids and acetoacetate became most obvious in cells stimulated with oxysterols or retinoic acid but was independent of the expression of the thereby regulated transcription factors liver-X-receptor alpha (LXRalpha) and retinoid-X-receptor alpha (RXRalpha), respectively.	Fatty Acids, Unsaturated	26-49	retinoid X receptor alpha	Mus musculus	290-298
12351428-7	2002	Unsaturated fatty acids and acetoacetate also reduced ABCA1 promotor activity in RAW264.7 macrophages that were transfected with a 968-bp ABCA1 promotor/luciferase gene construct.	Fatty Acids, Unsaturated	0-23	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	54-59
12351428-7	2002	Unsaturated fatty acids and acetoacetate also reduced ABCA1 promotor activity in RAW264.7 macrophages that were transfected with a 968-bp ABCA1 promotor/luciferase gene construct.	Fatty Acids, Unsaturated	0-23	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	138-143
12583601-8	2002	Although triglycerides do not cross the placental barrier, the presence of lipoprotein receptors in the placenta, together with lipoprotein lipase, phospholipase A2, and intracellular lipase activities, allows the release to the fetus of polyunsaturated fatty acids transported as triglycerides in maternal plasma lipoproteins.	Fatty Acids, Unsaturated	238-265	lipoprotein lipase	Homo sapiens	128-146
12583601-8	2002	Although triglycerides do not cross the placental barrier, the presence of lipoprotein receptors in the placenta, together with lipoprotein lipase, phospholipase A2, and intracellular lipase activities, allows the release to the fetus of polyunsaturated fatty acids transported as triglycerides in maternal plasma lipoproteins.	Fatty Acids, Unsaturated	238-265	phospholipase A2 group IB	Homo sapiens	148-190
12364560-6	2002	While the PUFA/cholesterol (PUFA/CH) diets repressed the maturation of the SREBP-1, the SCD1 mRNA levels, and protein and enzyme activity were induced.	Fatty Acids, Unsaturated	10-14	sterol regulatory element binding transcription factor 1	Mus musculus	75-82
12364560-6	2002	While the PUFA/cholesterol (PUFA/CH) diets repressed the maturation of the SREBP-1, the SCD1 mRNA levels, and protein and enzyme activity were induced.	Fatty Acids, Unsaturated	10-14	stearoyl-Coenzyme A desaturase 1	Mus musculus	88-92
12364560-10	2002	This study demonstrates that cholesterol overrides the PUFA-mediated repression of the SCD1 gene and regulates SCD1 gene expression through a mechanism independent of SREBP-1 maturation.	Fatty Acids, Unsaturated	55-59	stearoyl-Coenzyme A desaturase 1	Mus musculus	87-91
12364560-4	2002	Previous in vivo studies have shown that the transcriptional repression by n-3 and n-6 polyunsaturated fatty acids (PUFAs) and the induction by cholesterol of the SCD1 gene are dependent on the maturation of the sterol regulatory element-binding protein-1c (SREBP-1c).	Fatty Acids, Unsaturated	116-121	sterol regulatory element binding transcription factor 1	Mus musculus	258-266
12213493-3	2002	In potato cells, pathogen-derived elicitors preferentially stimulate the 9-LOX-dependent metabolism of polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	103-130	probable linoleate 9S-lipoxygenase 5	Solanum tuberosum	75-78
12356468-1	2002	Delta(3)-Delta(2)-Enoyl-CoA isomerase (EC 5.3.3.8) is a key enzyme for the beta-oxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	93-116	enoyl-CoA delta isomerase 1	Rattus norvegicus	0-37
12124392-8	2002	Lyso-PC and polyunsaturated fatty acids including AA activated cPLA(2) and 5-lipoxygenase by increasing [Ca(2+)](i) and inducing cPLA(2) phosphorylation, which then led to LTB(4) biosynthesis.	Fatty Acids, Unsaturated	12-39	phospholipase A2 group IVA	Homo sapiens	63-69
12124392-8	2002	Lyso-PC and polyunsaturated fatty acids including AA activated cPLA(2) and 5-lipoxygenase by increasing [Ca(2+)](i) and inducing cPLA(2) phosphorylation, which then led to LTB(4) biosynthesis.	Fatty Acids, Unsaturated	12-39	phospholipase A2 group IVA	Homo sapiens	129-135
12091394-2	2002	This study investigated the possibility that treatment with the polyunsaturated fatty acid eicosapentaenoic acid might prevent interleukin-1beta-induced deterioration in neuronal function.	Fatty Acids, Unsaturated	64-90	interleukin 1 beta	Rattus norvegicus	127-144
12213584-3	2002	The hepatic lipogenic enzyme, fatty acid synthase (FAS) is negatively regulated by polyunsaturated FAs (PUFAs) which suppress sterol regulatory element-binding protein 1 (SREBP 1) gene expression and nuclear content in hepatocytes, thereby reducing FAS gene transcription.	Fatty Acids, Unsaturated	83-102	fatty acid synthase	Homo sapiens	30-49
12213584-3	2002	The hepatic lipogenic enzyme, fatty acid synthase (FAS) is negatively regulated by polyunsaturated FAs (PUFAs) which suppress sterol regulatory element-binding protein 1 (SREBP 1) gene expression and nuclear content in hepatocytes, thereby reducing FAS gene transcription.	Fatty Acids, Unsaturated	83-102	fatty acid synthase	Homo sapiens	51-54
12213584-3	2002	The hepatic lipogenic enzyme, fatty acid synthase (FAS) is negatively regulated by polyunsaturated FAs (PUFAs) which suppress sterol regulatory element-binding protein 1 (SREBP 1) gene expression and nuclear content in hepatocytes, thereby reducing FAS gene transcription.	Fatty Acids, Unsaturated	83-102	sterol regulatory element binding transcription factor 1	Homo sapiens	126-169
12213584-3	2002	The hepatic lipogenic enzyme, fatty acid synthase (FAS) is negatively regulated by polyunsaturated FAs (PUFAs) which suppress sterol regulatory element-binding protein 1 (SREBP 1) gene expression and nuclear content in hepatocytes, thereby reducing FAS gene transcription.	Fatty Acids, Unsaturated	83-102	sterol regulatory element binding transcription factor 1	Homo sapiens	171-178
12213584-3	2002	The hepatic lipogenic enzyme, fatty acid synthase (FAS) is negatively regulated by polyunsaturated FAs (PUFAs) which suppress sterol regulatory element-binding protein 1 (SREBP 1) gene expression and nuclear content in hepatocytes, thereby reducing FAS gene transcription.	Fatty Acids, Unsaturated	83-102	fatty acid synthase	Homo sapiens	249-252
12213584-3	2002	The hepatic lipogenic enzyme, fatty acid synthase (FAS) is negatively regulated by polyunsaturated FAs (PUFAs) which suppress sterol regulatory element-binding protein 1 (SREBP 1) gene expression and nuclear content in hepatocytes, thereby reducing FAS gene transcription.	Fatty Acids, Unsaturated	104-109	fatty acid synthase	Homo sapiens	30-49
12213584-3	2002	The hepatic lipogenic enzyme, fatty acid synthase (FAS) is negatively regulated by polyunsaturated FAs (PUFAs) which suppress sterol regulatory element-binding protein 1 (SREBP 1) gene expression and nuclear content in hepatocytes, thereby reducing FAS gene transcription.	Fatty Acids, Unsaturated	104-109	fatty acid synthase	Homo sapiens	51-54
12213584-3	2002	The hepatic lipogenic enzyme, fatty acid synthase (FAS) is negatively regulated by polyunsaturated FAs (PUFAs) which suppress sterol regulatory element-binding protein 1 (SREBP 1) gene expression and nuclear content in hepatocytes, thereby reducing FAS gene transcription.	Fatty Acids, Unsaturated	104-109	sterol regulatory element binding transcription factor 1	Homo sapiens	126-169
12213584-3	2002	The hepatic lipogenic enzyme, fatty acid synthase (FAS) is negatively regulated by polyunsaturated FAs (PUFAs) which suppress sterol regulatory element-binding protein 1 (SREBP 1) gene expression and nuclear content in hepatocytes, thereby reducing FAS gene transcription.	Fatty Acids, Unsaturated	104-109	sterol regulatory element binding transcription factor 1	Homo sapiens	171-178
12213584-3	2002	The hepatic lipogenic enzyme, fatty acid synthase (FAS) is negatively regulated by polyunsaturated FAs (PUFAs) which suppress sterol regulatory element-binding protein 1 (SREBP 1) gene expression and nuclear content in hepatocytes, thereby reducing FAS gene transcription.	Fatty Acids, Unsaturated	104-109	fatty acid synthase	Homo sapiens	249-252
12213584-4	2002	It was proposed recently that this reduction in SREBP 1 was the result of a PUFA-induced antagonism of ligand-dependent activation of the liver X nuclear receptor (LXR), known to be an inducer of the SREBP 1 gene.	Fatty Acids, Unsaturated	76-80	sterol regulatory element binding transcription factor 1	Homo sapiens	48-55
12213584-4	2002	It was proposed recently that this reduction in SREBP 1 was the result of a PUFA-induced antagonism of ligand-dependent activation of the liver X nuclear receptor (LXR), known to be an inducer of the SREBP 1 gene.	Fatty Acids, Unsaturated	76-80	sterol regulatory element binding transcription factor 1	Homo sapiens	200-207
12354283-2	2002	The present study was designed to investigate whether the Caenorhabditis elegans fat-1 gene encoding an n-3 fatty acid desaturase (an enzyme that converts n-6 PUFAs to corresponding n-3 PUFAs) can be expressed functionally in rat cortical neurons and whether its expression can change the ratio of n-6 : n-3 fatty acids in the cell membrane and exert an effect on neuronal apoptosis.	Fatty Acids, Unsaturated	159-164	Omega-3 fatty acid desaturase fat-1	Caenorhabditis elegans	81-86
12237244-6	2002	Inhibition of AR expression could be achieved by potential chemopreventive agents flufenamic acid, resveratrol, quercetin, polyunsaturated fatty acids and interleukin-1beta, and by the application of AR antisense oligonucleotides.	Fatty Acids, Unsaturated	123-150	androgen receptor	Homo sapiens	14-16
12021277-4	2002	sPLA2-X was found to induce potent hydrolysis of phosphatidylcholine in LDL leading to the production of large amounts of unsaturated fatty acids and lysophosphatidylcholine (lyso-PC), which contrasted with little, if any, lipolytic modification of LDL by the classic types of group IB and IIA secretory PLA2s.	Fatty Acids, Unsaturated	122-145	phospholipase A2, group X	Mus musculus	0-7
12392789-4	2002	The significantly higher level of cholesterol in aging neuronal membrane, the slow rate of cholesterol turnover, and the decreased level of total polyunsaturated fatty acids (PUFA) may result from poor passage rate via the blood-brain barrier, or from a decreased rate of incorporation into the membrane, or a decrease in the activities of delta-6 and delta-9 desaturase enzymes.	Fatty Acids, Unsaturated	175-179	fatty acid desaturase 3	Homo sapiens	340-370
12029091-0	2002	LAT displacement from lipid rafts as a molecular mechanism for the inhibition of T cell signaling by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	101-128	linker for activation of T cells	Homo sapiens	0-3
12065583-5	2002	Conversely, polyunsaturated fatty acids such as docosahexaenoic acid and eicosapentaenoic acid showed antagonistic activities against TG1019.	Fatty Acids, Unsaturated	12-39	oxoeicosanoid receptor 1	Homo sapiens	134-140
12072438-0	2002	Inhibition of the splicing of glucose-6-phosphate dehydrogenase precursor mRNA by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	82-109	glucose-6-phosphate dehydrogenase 2	Mus musculus	30-63
12072438-1	2002	Polyunsaturated fatty acids inhibit the expression of hepatic glucose-6-phosphate dehydrogenase (G6PD) by changes in the amount of G6PD pre-mRNA in the nucleus in the absence of changes in the transcription rate of the gene.	Fatty Acids, Unsaturated	0-27	glucose-6-phosphate dehydrogenase 2	Mus musculus	62-95
12072438-1	2002	Polyunsaturated fatty acids inhibit the expression of hepatic glucose-6-phosphate dehydrogenase (G6PD) by changes in the amount of G6PD pre-mRNA in the nucleus in the absence of changes in the transcription rate of the gene.	Fatty Acids, Unsaturated	0-27	glucose-6-phosphate dehydrogenase 2	Mus musculus	97-101
12072438-1	2002	Polyunsaturated fatty acids inhibit the expression of hepatic glucose-6-phosphate dehydrogenase (G6PD) by changes in the amount of G6PD pre-mRNA in the nucleus in the absence of changes in the transcription rate of the gene.	Fatty Acids, Unsaturated	0-27	glucose-6-phosphate dehydrogenase 2	Mus musculus	131-135
12072438-8	2002	The presence of both exon 12 and a neighboring intron within the G6PD reporter RNA was essential for regulation by polyunsaturated fatty acid.	Fatty Acids, Unsaturated	115-141	glucose-6-phosphate dehydrogenase 2	Mus musculus	65-69
12147235-0	2002	The E-box like sterol regulatory element mediates the suppression of human Delta-6 desaturase gene by highly unsaturated fatty acids.	Fatty Acids, Unsaturated	109-132	fatty acid desaturase 2	Homo sapiens	75-93
12021277-4	2002	sPLA2-X was found to induce potent hydrolysis of phosphatidylcholine in LDL leading to the production of large amounts of unsaturated fatty acids and lysophosphatidylcholine (lyso-PC), which contrasted with little, if any, lipolytic modification of LDL by the classic types of group IB and IIA secretory PLA2s.	Fatty Acids, Unsaturated	122-145	ATPase, class II, type 9A	Mus musculus	290-293
12021277-8	2002	These findings suggest that modification of LDL by sPLA2-X in the arterial vessels is one of the mechanisms responsible for the generation of atherogenic lipoprotein particles as well as the production of various lipid mediators, including unsaturated fatty acids and lyso-PC.	Fatty Acids, Unsaturated	240-263	phospholipase A2, group X	Mus musculus	51-58
12104084-14	2002	The increase in polyunsaturated fatty acid content in phospholipid and cholesterol ester significantly correlated with decreased lag time.	Fatty Acids, Unsaturated	16-42	stathmin 1	Homo sapiens	129-132
12195157-3	2002	Peroxisome proliferator-activated receptor (PPAR) gamma is a nuclear receptor that is activated by PUFAs, eicosanoids and antidiabetic agents such as troglitazone.	Fatty Acids, Unsaturated	99-104	peroxisome proliferator activated receptor gamma	Homo sapiens	0-55
12090925-1	2002	Alteration of the polyunsaturated fatty acid (PUFA) composition of milk by dietary supplementation of cows may be beneficial to human health.	Fatty Acids, Unsaturated	46-50	PUFA	Bos taurus	18-44
12163668-1	2002	The study was designed to evaluate the chronic regulation of plasma leptin by dietary (n-3) polyunsaturated fatty acids (PUFA) in insulin-resistant, sucrose-fed rats.	Fatty Acids, Unsaturated	121-125	leptin	Rattus norvegicus	68-74
12111278-6	2002	Giving a polyunsaturated fatty acid (omega-3) supplemented diet for eight weeks induced a large rise of the FABP(c) in EDL (300%), gastrocnemius (250%), soleus (50%) and heart (15%) without a concurrent accumulation of intramuscular triglycerides or modification of the citrate synthase activity, suggesting that polyunsaturated fatty acids may increase FABP(c) content by up-regulating fatty acid metabolism genes via peroxisome proliferator-activated receptor alpha activation.	Fatty Acids, Unsaturated	9-35	fatty acid binding protein 2	Rattus norvegicus	108-112
12111278-6	2002	Giving a polyunsaturated fatty acid (omega-3) supplemented diet for eight weeks induced a large rise of the FABP(c) in EDL (300%), gastrocnemius (250%), soleus (50%) and heart (15%) without a concurrent accumulation of intramuscular triglycerides or modification of the citrate synthase activity, suggesting that polyunsaturated fatty acids may increase FABP(c) content by up-regulating fatty acid metabolism genes via peroxisome proliferator-activated receptor alpha activation.	Fatty Acids, Unsaturated	9-35	citrate synthase	Rattus norvegicus	270-286
12111278-6	2002	Giving a polyunsaturated fatty acid (omega-3) supplemented diet for eight weeks induced a large rise of the FABP(c) in EDL (300%), gastrocnemius (250%), soleus (50%) and heart (15%) without a concurrent accumulation of intramuscular triglycerides or modification of the citrate synthase activity, suggesting that polyunsaturated fatty acids may increase FABP(c) content by up-regulating fatty acid metabolism genes via peroxisome proliferator-activated receptor alpha activation.	Fatty Acids, Unsaturated	9-35	fatty acid binding protein 2	Rattus norvegicus	354-358
12111278-6	2002	Giving a polyunsaturated fatty acid (omega-3) supplemented diet for eight weeks induced a large rise of the FABP(c) in EDL (300%), gastrocnemius (250%), soleus (50%) and heart (15%) without a concurrent accumulation of intramuscular triglycerides or modification of the citrate synthase activity, suggesting that polyunsaturated fatty acids may increase FABP(c) content by up-regulating fatty acid metabolism genes via peroxisome proliferator-activated receptor alpha activation.	Fatty Acids, Unsaturated	9-35	peroxisome proliferator activated receptor alpha	Rattus norvegicus	419-467
12111278-6	2002	Giving a polyunsaturated fatty acid (omega-3) supplemented diet for eight weeks induced a large rise of the FABP(c) in EDL (300%), gastrocnemius (250%), soleus (50%) and heart (15%) without a concurrent accumulation of intramuscular triglycerides or modification of the citrate synthase activity, suggesting that polyunsaturated fatty acids may increase FABP(c) content by up-regulating fatty acid metabolism genes via peroxisome proliferator-activated receptor alpha activation.	Fatty Acids, Unsaturated	313-340	fatty acid binding protein 2	Rattus norvegicus	108-112
12455996-0	2002	Mga2p processing by hypoxia and unsaturated fatty acids in Saccharomyces cerevisiae: impact on LORE-dependent gene expression.	Fatty Acids, Unsaturated	32-55	Mga2p	Saccharomyces cerevisiae S288C	0-5
12093533-9	2002	These data suggest that SCP-2 expression selectively shifted the distribution of lipids (cholesterol, LBPA, esterified polyunsaturated fatty acids) away from lysosomal membranes.	Fatty Acids, Unsaturated	119-146	sterol carrier protein 2	Homo sapiens	24-29
12031956-10	2002	The increase in overt DGAT activity induced by fenofibrate could not be mimicked by feeding a diet enriched in n-3 polyunsaturated fatty acids (PUFA), which lowered overt DGAT activity but did not affect latent DGAT, suggesting that n-3 PUFA act through a mechanism independent of PPARalpha activation.	Fatty Acids, Unsaturated	144-148	diacylglycerol O-acyltransferase 1	Rattus norvegicus	171-175
12031956-10	2002	The increase in overt DGAT activity induced by fenofibrate could not be mimicked by feeding a diet enriched in n-3 polyunsaturated fatty acids (PUFA), which lowered overt DGAT activity but did not affect latent DGAT, suggesting that n-3 PUFA act through a mechanism independent of PPARalpha activation.	Fatty Acids, Unsaturated	144-148	diacylglycerol O-acyltransferase 1	Rattus norvegicus	171-175
12455996-7	2002	Hypoxic induction of OLE1, however, is associated with increased processing of the protein, resulting in an approximately fivefold increase in the soluble active form that is counteracted by exposure of the cells to unsaturated fatty acids.	Fatty Acids, Unsaturated	216-239	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	21-25
12010762-8	2002	On the other hand, cis-9, trans-11 enhanced the UCP1 elicited by NE, an effect reported earlier for polyunsaturated fatty acids and also observed here for linoleic acid.	Fatty Acids, Unsaturated	100-127	uncoupling protein 1	Homo sapiens	48-52
12079830-4	2002	PPARalpha has been shown to bind and to be activated by leukotriene B4 and the hypolipidemic drugs of the fibrate class; PPARbeta/delta ligands are polyunsaturated fatty acids and prostaglandins; while prostaglandin J2 derivatives and the antidiabetic glitazones are, respectively, natural and synthetic ligands for PPARgamma.	Fatty Acids, Unsaturated	148-175	peroxisome proliferator activated receptor alpha	Homo sapiens	0-9
12079830-4	2002	PPARalpha has been shown to bind and to be activated by leukotriene B4 and the hypolipidemic drugs of the fibrate class; PPARbeta/delta ligands are polyunsaturated fatty acids and prostaglandins; while prostaglandin J2 derivatives and the antidiabetic glitazones are, respectively, natural and synthetic ligands for PPARgamma.	Fatty Acids, Unsaturated	148-175	peroxisome proliferator activated receptor delta	Homo sapiens	121-129
12079833-0	2002	Sterol regulatory element-binding proteins (SREBPs) as regulators of lipid metabolism: polyunsaturated fatty acids oppose cholesterol-mediated induction of SREBP-1 maturation.	Fatty Acids, Unsaturated	87-114	sterol regulatory element binding transcription factor 1	Homo sapiens	156-163
12079833-4	2002	Of the three SREBP isoforms, SREBP-1c gene expression is induced by cholesterol and repressed by polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	97-124	sterol regulatory element binding transcription factor 1	Homo sapiens	29-37
12079833-4	2002	Of the three SREBP isoforms, SREBP-1c gene expression is induced by cholesterol and repressed by polyunsaturated fatty acids (PUFA).	Fatty Acids, Unsaturated	126-130	sterol regulatory element binding transcription factor 1	Homo sapiens	29-37
12031897-1	2002	The influence of chylomicron remnants enriched in n-6 or n-3 polyunsaturated fatty acids (PUFA) on the expression of mRNA for the low density lipoprotein receptor (LDLr), LDLr-related protein (LRP), and peroxisome proliferator activated receptor alpha (PPAR(alpha)) was investigated in normal hepatocytes and after manipulation of the cellular oxidative state by incubation with N-acetyl cysteine (NAC) or CuSO(4).	Fatty Acids, Unsaturated	90-94	low density lipoprotein receptor	Homo sapiens	130-162
12455996-2	2002	Previous studies have demonstrated that (i) OLE1 expression is repressed by unsaturated fatty acids (UFAs) and induced by low oxygen tension, (ii) a component of this regulation is mediated through the same low oxygen response element (LORE) in the OLE1 promoter, and (iii) Mga2p is involved in LORE-dependent hypoxic induction of OLE1.	Fatty Acids, Unsaturated	76-99	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	44-48
12455996-2	2002	Previous studies have demonstrated that (i) OLE1 expression is repressed by unsaturated fatty acids (UFAs) and induced by low oxygen tension, (ii) a component of this regulation is mediated through the same low oxygen response element (LORE) in the OLE1 promoter, and (iii) Mga2p is involved in LORE-dependent hypoxic induction of OLE1.	Fatty Acids, Unsaturated	76-99	Mga2p	Saccharomyces cerevisiae S288C	274-279
12455996-2	2002	Previous studies have demonstrated that (i) OLE1 expression is repressed by unsaturated fatty acids (UFAs) and induced by low oxygen tension, (ii) a component of this regulation is mediated through the same low oxygen response element (LORE) in the OLE1 promoter, and (iii) Mga2p is involved in LORE-dependent hypoxic induction of OLE1.	Fatty Acids, Unsaturated	101-105	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	44-48
12455996-3	2002	We now report that LORE-CYC1 basal promoter-lacZ fusion reporter assays demonstrate that UFAs repress the reporter expression under hypoxic conditions in a dose-dependent manner via LORE.	Fatty Acids, Unsaturated	89-93	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	24-28
12455996-5	2002	Studies with a construct encoding a truncated form of Mga2p support the hypothesis that both hypoxia and UFA signals affect the processing of Mga2p and the UFA repression of OLE1 hypoxic induction is mediated through Mga2p.	Fatty Acids, Unsaturated	105-108	Mga2p	Saccharomyces cerevisiae S288C	54-59
12455996-5	2002	Studies with a construct encoding a truncated form of Mga2p support the hypothesis that both hypoxia and UFA signals affect the processing of Mga2p and the UFA repression of OLE1 hypoxic induction is mediated through Mga2p.	Fatty Acids, Unsaturated	105-108	Mga2p	Saccharomyces cerevisiae S288C	142-147
12455996-5	2002	Studies with a construct encoding a truncated form of Mga2p support the hypothesis that both hypoxia and UFA signals affect the processing of Mga2p and the UFA repression of OLE1 hypoxic induction is mediated through Mga2p.	Fatty Acids, Unsaturated	105-108	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	174-178
12455996-5	2002	Studies with a construct encoding a truncated form of Mga2p support the hypothesis that both hypoxia and UFA signals affect the processing of Mga2p and the UFA repression of OLE1 hypoxic induction is mediated through Mga2p.	Fatty Acids, Unsaturated	105-108	Mga2p	Saccharomyces cerevisiae S288C	142-147
12455996-5	2002	Studies with a construct encoding a truncated form of Mga2p support the hypothesis that both hypoxia and UFA signals affect the processing of Mga2p and the UFA repression of OLE1 hypoxic induction is mediated through Mga2p.	Fatty Acids, Unsaturated	156-159	Mga2p	Saccharomyces cerevisiae S288C	54-59
12455996-5	2002	Studies with a construct encoding a truncated form of Mga2p support the hypothesis that both hypoxia and UFA signals affect the processing of Mga2p and the UFA repression of OLE1 hypoxic induction is mediated through Mga2p.	Fatty Acids, Unsaturated	156-159	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	174-178
12513123-2	2002	Hepatic ADD1 transcripts are reduced by polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	40-67	adducin 1	Homo sapiens	8-12
12032166-7	2002	Dietary PUFAs caused a profound suppression of this gene expression, which could be restored by SREBP-1c overexpression.	Fatty Acids, Unsaturated	8-13	sterol regulatory element binding transcription factor 1	Homo sapiens	96-104
12513123-2	2002	Hepatic ADD1 transcripts are reduced by polyunsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	69-74	adducin 1	Homo sapiens	8-12
12037643-11	2002	Dietary fatty acids, particularly polyunsaturated fatty acids, are known to regulate adipocyte differentiation through the nuclear peroxisome proliferator-activated receptor gamma, and may also have a role in insulin resistance.	Fatty Acids, Unsaturated	34-61	peroxisome proliferator activated receptor gamma	Homo sapiens	131-179
12037643-11	2002	Dietary fatty acids, particularly polyunsaturated fatty acids, are known to regulate adipocyte differentiation through the nuclear peroxisome proliferator-activated receptor gamma, and may also have a role in insulin resistance.	Fatty Acids, Unsaturated	34-61	insulin	Homo sapiens	209-216
11988075-0	2002	The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	105-131	fatty acid desaturase 2	Rattus norvegicus	19-30
12055328-1	2002	OBJECTIVE: To verify whether polyunsaturated fatty acids (PUFAs) can regulate the expression of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) in human adipose tissue.	Fatty Acids, Unsaturated	29-56	peroxisome proliferator activated receptor gamma	Homo sapiens	117-165
12055328-1	2002	OBJECTIVE: To verify whether polyunsaturated fatty acids (PUFAs) can regulate the expression of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) in human adipose tissue.	Fatty Acids, Unsaturated	29-56	peroxisome proliferator activated receptor gamma	Homo sapiens	167-176
12055328-1	2002	OBJECTIVE: To verify whether polyunsaturated fatty acids (PUFAs) can regulate the expression of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) in human adipose tissue.	Fatty Acids, Unsaturated	58-63	peroxisome proliferator activated receptor gamma	Homo sapiens	117-165
12055328-1	2002	OBJECTIVE: To verify whether polyunsaturated fatty acids (PUFAs) can regulate the expression of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) in human adipose tissue.	Fatty Acids, Unsaturated	58-63	peroxisome proliferator activated receptor gamma	Homo sapiens	167-176
11988075-1	2002	The recently cloned Delta6-desaturase is known to catalyse the first step in very-long-chain polyunsaturated fatty acid biosynthesis, i.e. the desaturation of linoleic and alpha-linolenic acids.	Fatty Acids, Unsaturated	93-119	fatty acid desaturase 2	Rattus norvegicus	26-37
12058962-2	2002	We examined how y-linolenic acid (GLA; 18: 3n-6), the most promising UFA in the treatment of human tumors, affects the effectiveness of the lipophilic drug vinorelbine (VNR) on human breast carcinoma cell lines.	Fatty Acids, Unsaturated	69-72	galactosidase alpha	Homo sapiens	34-37
11971939-0	2002	Suppression of fatty acid synthase promoter by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	47-74	fatty acid synthase	Homo sapiens	15-34
11971939-4	2002	Here, we first examined the DNA sequences responsible for SREBP-mediated suppression of FAS promoter activity by polyunsaturated fatty acids (PUFA) in vivo.	Fatty Acids, Unsaturated	113-140	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	58-63
11971939-4	2002	Here, we first examined the DNA sequences responsible for SREBP-mediated suppression of FAS promoter activity by polyunsaturated fatty acids (PUFA) in vivo.	Fatty Acids, Unsaturated	113-140	fatty acid synthase	Homo sapiens	88-91
11971939-4	2002	Here, we first examined the DNA sequences responsible for SREBP-mediated suppression of FAS promoter activity by polyunsaturated fatty acids (PUFA) in vivo.	Fatty Acids, Unsaturated	142-146	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	58-63
11971939-4	2002	Here, we first examined the DNA sequences responsible for SREBP-mediated suppression of FAS promoter activity by polyunsaturated fatty acids (PUFA) in vivo.	Fatty Acids, Unsaturated	142-146	fatty acid synthase	Homo sapiens	88-91
11906823-13	2002	The addition of linoleic acid reverted this pattern and indicated that the Delta 5 desaturase activity is a limiting step in the polyunsaturated fatty acid biosynthesis.	Fatty Acids, Unsaturated	129-155	fatty acid desaturase 1	Rattus norvegicus	75-93
11844797-4	2002	However, the addition of unsaturated fatty acids (i.e. arachidonate 1-50 microm) up-regulated phosphorylation of 5-LO, but not of Hsp-27, by active MK2 in vitro, resulting in a similar phosphorylation as for Hsp-27.	Fatty Acids, Unsaturated	25-48	heat shock protein family B (small) member 1	Homo sapiens	130-136
11844797-4	2002	However, the addition of unsaturated fatty acids (i.e. arachidonate 1-50 microm) up-regulated phosphorylation of 5-LO, but not of Hsp-27, by active MK2 in vitro, resulting in a similar phosphorylation as for Hsp-27.	Fatty Acids, Unsaturated	25-48	MAPK activated protein kinase 2	Homo sapiens	148-151
11844797-4	2002	However, the addition of unsaturated fatty acids (i.e. arachidonate 1-50 microm) up-regulated phosphorylation of 5-LO, but not of Hsp-27, by active MK2 in vitro, resulting in a similar phosphorylation as for Hsp-27.	Fatty Acids, Unsaturated	25-48	heat shock protein family B (small) member 1	Homo sapiens	208-214
12058962-12	2002	Under conditions inhibiting lipid peroxidation using Vitamin E (dl-alpha-tocopherol), the enhancing effect of GLA (an easily oxidizable UFA) on VNR activity was partially abolished.	Fatty Acids, Unsaturated	136-139	galactosidase alpha	Homo sapiens	110-113
12058962-15	2002	For comparison, the effects of other UFAs were examined on VNR chemosensitivity: GLA was the most potent at enhancing VNR activity, followed by docosahexaenoic acid (22: 6n-3), eicosapentaenoic acid (20: 5n-3) and alpha-linolenic acid (18: 3n-3), whereas linoleic acid (18: 2n-6) and arachidonic acid (20: 4n-6) did not increase VNR chemosensitivity.	Fatty Acids, Unsaturated	37-41	galactosidase alpha	Homo sapiens	81-84
12064337-4	2002	Here, we examined the expression of BRCA1 and BRCA2 in breast cell lines after treatment with polyunsaturated fatty acids.	Fatty Acids, Unsaturated	94-121	BRCA1 DNA repair associated	Homo sapiens	36-41
12064337-4	2002	Here, we examined the expression of BRCA1 and BRCA2 in breast cell lines after treatment with polyunsaturated fatty acids.	Fatty Acids, Unsaturated	94-121	BRCA2 DNA repair associated	Homo sapiens	46-51
12020783-0	2002	Polyunsaturated fatty acids of germ cell membranes, glutathione and blutathione-dependent enzyme-PHGPx: from basic to clinic.	Fatty Acids, Unsaturated	0-27	glutathione peroxidase 4	Homo sapiens	97-102
11874473-12	2002	In turn, the genital tract, the epithelia of which are rich in GR, functions in an antioxidative manner to protect sulfhydryl groups and unsaturated fatty acids in spermatozoa from oxidation during the maturation process and storage.	Fatty Acids, Unsaturated	137-160	glutathione-disulfide reductase	Rattus norvegicus	63-65
11966935-1	2002	BACKGROUND: Polyunsaturated fatty acids have the potential to attenuate inflammation by the synthesis of mediators of the 15-lipoxygenase pathways, which show opposite effects to the pro-inflammatory arachidonic acid metabolites such as leukotriene B4 (LTB4).	Fatty Acids, Unsaturated	12-39	arachidonate 15-lipoxygenase	Homo sapiens	122-137
11907148-6	2002	Three fluorometric assays were employed, all of which showed strong binding (K(d)" approximately 10(-8) to 10(-7) M) of 20-, 22-, and 24-carbon n-3 PUFAs to L-FABP.	Fatty Acids, Unsaturated	148-153	fatty acid binding protein 1	Homo sapiens	157-163
11916926-8	2002	The troglitazone-induced decrease in Delta-6 desaturase mRNA is associated with a change in the unsaturated fatty acid composition of the muscle cells.	Fatty Acids, Unsaturated	96-118	fatty acid desaturase 2	Homo sapiens	37-55
11998897-0	2002	Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes.	Fatty Acids, Unsaturated	47-69	interleukin 1 beta	Homo sapiens	115-132
11914740-0	2002	Components of the insulin resistance syndrome in seven-year-old children: relations with birth weight and the polyunsaturated fatty acid content of umbilical cord plasma phospholipids.	Fatty Acids, Unsaturated	110-136	insulin	Homo sapiens	18-25
11914740-2	2002	In adults, insulin resistance has been associated with dietary polyunsaturated fatty acids.	Fatty Acids, Unsaturated	63-90	insulin	Homo sapiens	11-18
11914742-8	2002	Insulin sensitivity and plasma low density lipoprotein cholesterol concentrations improved with the diet rich in polyunsaturated fatty acids compared with the diet rich in saturated fatty acids.	Fatty Acids, Unsaturated	113-140	insulin	Homo sapiens	0-7
11921647-5	2002	Iodinated organic compounds, in particular iodolacton produced by iodination of unsaturated fatty acids in the thyrocyte, are the key regulators of IGF1 activity by inhibitory action, and iodine is now the therapeutic agent of first choice for iodine deficiency goiter; long-term thyroxine treatment in TSH suppressive doses has been abandoned.	Fatty Acids, Unsaturated	80-103	insulin like growth factor 1	Homo sapiens	148-152
11882947-4	2002	Analysis of the enzymatic properties of ABI2 revealed high sensitivities towards protons and unsaturated fatty acids.	Fatty Acids, Unsaturated	93-116	Protein phosphatase 2C family protein	Arabidopsis thaliana	40-44
11741998-4	2002	Results showed that unsaturated fatty acids markedly inhibited ABCA1-mediated cholesterol and phospholipid efflux from macrophages when ABCA1 was induced by a cAMP analog.	Fatty Acids, Unsaturated	20-43	ATP binding cassette subfamily A member 1	Homo sapiens	63-68
11741998-4	2002	Results showed that unsaturated fatty acids markedly inhibited ABCA1-mediated cholesterol and phospholipid efflux from macrophages when ABCA1 was induced by a cAMP analog.	Fatty Acids, Unsaturated	20-43	ATP binding cassette subfamily A member 1	Homo sapiens	136-141
11741998-8	2002	Unsaturated fatty acids, however, increased ABCA1 turnover when protein synthesis was blocked by cycloheximide.	Fatty Acids, Unsaturated	0-23	ATP binding cassette subfamily A member 1	Homo sapiens	44-49
11741998-9	2002	We conclude that unsaturated fatty acids reduce the macrophage ABCA1 content by enhancing its degradation rate.	Fatty Acids, Unsaturated	17-40	ATP binding cassette subfamily A member 1	Homo sapiens	63-68
11847109-1	2002	The OLE pathway of yeast regulates the abundance of the ER-bound enzyme Delta-9 fatty acid desaturase OLE1, thereby controlling unsaturated fatty acid pools and membrane fluidity.	Fatty Acids, Unsaturated	128-150	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	102-106
11741998-10	2002	These findings raise the possibility that an increased supply of unsaturated fatty acids in the artery wall promotes atherogenesis by impairing the ABCA1 cholesterol secretory pathway in macrophages.	Fatty Acids, Unsaturated	65-88	ATP binding cassette subfamily A member 1	Homo sapiens	148-153
11779158-3	2002	PPARdelta is activated by unsaturated fatty acids, PGI2, and by synthetic ligands.	Fatty Acids, Unsaturated	26-49	peroxisome proliferator activator receptor delta	Mus musculus	0-9
11855929-2	2002	Straight-chain acyl-CoA oxidase (AOX) catalyzes the first, rate-limiting step of peroxisomal beta-oxidation of very-long-chain saturated and unsaturated fatty acids.	Fatty Acids, Unsaturated	141-164	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	33-36
11855929-3	2002	We have studied the polyunsaturated fatty acid metabolism of AOX knockout mice (AOX-/- as a model of human AOX deficiency (pseudo-neonatal adrenoleukodystrophy), and as a genetic tool to test the putative peroxisomal beta-oxidation involvement in polyunsaturated fatty acid synthesis.	Fatty Acids, Unsaturated	20-46	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	61-64
11844650-3	2002	RESULTS: Estrogen, statins, and PUFAs enhance nitric oxide synthesis, suppress the production of proinflammatory cytokines such as tumor necrosis factor(alpha), interleukin-1, interleukin-2, and interleukin-6, show antioxidant-like and antiatherosclerotic properties, have neuroprotective actions, and by themselves or their products inhibit tumor cell proliferation and improve osteoporosis.	Fatty Acids, Unsaturated	32-37	tumor necrosis factor	Homo sapiens	131-159
11844650-3	2002	RESULTS: Estrogen, statins, and PUFAs enhance nitric oxide synthesis, suppress the production of proinflammatory cytokines such as tumor necrosis factor(alpha), interleukin-1, interleukin-2, and interleukin-6, show antioxidant-like and antiatherosclerotic properties, have neuroprotective actions, and by themselves or their products inhibit tumor cell proliferation and improve osteoporosis.	Fatty Acids, Unsaturated	32-37	interleukin 1 alpha	Homo sapiens	161-174
11844650-3	2002	RESULTS: Estrogen, statins, and PUFAs enhance nitric oxide synthesis, suppress the production of proinflammatory cytokines such as tumor necrosis factor(alpha), interleukin-1, interleukin-2, and interleukin-6, show antioxidant-like and antiatherosclerotic properties, have neuroprotective actions, and by themselves or their products inhibit tumor cell proliferation and improve osteoporosis.	Fatty Acids, Unsaturated	32-37	interleukin 2	Homo sapiens	176-189
11844650-3	2002	RESULTS: Estrogen, statins, and PUFAs enhance nitric oxide synthesis, suppress the production of proinflammatory cytokines such as tumor necrosis factor(alpha), interleukin-1, interleukin-2, and interleukin-6, show antioxidant-like and antiatherosclerotic properties, have neuroprotective actions, and by themselves or their products inhibit tumor cell proliferation and improve osteoporosis.	Fatty Acids, Unsaturated	32-37	interleukin 6	Homo sapiens	195-208
11844650-5	2002	For instance, the binding of estrogen to its receptor on the cell membrane may be determined by its lipid content, statins and PUFAs inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, statins influence the metabolism of PUFAs, and PUFA deficiency enhances 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.	Fatty Acids, Unsaturated	127-132	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	141-188
11923099-0	2002	Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations.	Fatty Acids, Unsaturated	124-128	fatty acid desaturase 1	Rattus norvegicus	34-45
11923099-3	2002	We recently reported that arachidonic acid (20:4) or linoleic acid (18:2) supplementations result in increases in abundances of long chain polyunsaturated fatty acids in INS-1 beta-cell membrane lipids, suggesting that beta-cells express desaturases that catalyze generation of unsaturated fatty acids.	Fatty Acids, Unsaturated	143-166	insulin 1	Rattus norvegicus	170-175
11923099-5	2002	Supplementation of the INS-1 beta-cells with arachidonic acid leads to decreased expression of all three desaturases, presumably in response to the decreased need for endogenous generation of unsaturated fatty acids.	Fatty Acids, Unsaturated	192-215	insulin 1	Rattus norvegicus	23-28
11694526-0	2002	Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Homo sapiens	37-81
11694526-1	2002	Previous studies have demonstrated that polyunsaturated fatty acids (PUFAs) suppress sterol regulatory element-binding protein 1c (SREBP-1c) expression and, thus, lipogenesis.	Fatty Acids, Unsaturated	40-67	sterol regulatory element binding transcription factor 1	Homo sapiens	85-129
11694526-1	2002	Previous studies have demonstrated that polyunsaturated fatty acids (PUFAs) suppress sterol regulatory element-binding protein 1c (SREBP-1c) expression and, thus, lipogenesis.	Fatty Acids, Unsaturated	40-67	sterol regulatory element binding transcription factor 1	Homo sapiens	131-139
11694526-1	2002	Previous studies have demonstrated that polyunsaturated fatty acids (PUFAs) suppress sterol regulatory element-binding protein 1c (SREBP-1c) expression and, thus, lipogenesis.	Fatty Acids, Unsaturated	69-74	sterol regulatory element binding transcription factor 1	Homo sapiens	85-129
11694526-1	2002	Previous studies have demonstrated that polyunsaturated fatty acids (PUFAs) suppress sterol regulatory element-binding protein 1c (SREBP-1c) expression and, thus, lipogenesis.	Fatty Acids, Unsaturated	69-74	sterol regulatory element binding transcription factor 1	Homo sapiens	131-139
11694526-5	2002	The luciferase activities of both SREBP-1c promoter and LXRE enhancer constructs induced by co-expression of LXRalpha or -beta were strongly suppressed by the addition of various PUFAs (arachidonic acid &gt; eicosapentaenoic acid &gt; docosahexaenoic acid &gt; linoleic acid), whereas saturated or mono-unsaturated fatty acids had minimal effects.	Fatty Acids, Unsaturated	179-184	sterol regulatory element binding transcription factor 1	Homo sapiens	34-42
11779162-6	2002	This is the first report that insulin, cAMP, and polyunsaturated fatty acids modulate the proximal SREBP-1c promoter in rat hepatocytes mirroring physiological regulation of SREBP-1c in vivo.	Fatty Acids, Unsaturated	49-76	sterol regulatory element binding transcription factor 1	Rattus norvegicus	99-107
11779162-6	2002	This is the first report that insulin, cAMP, and polyunsaturated fatty acids modulate the proximal SREBP-1c promoter in rat hepatocytes mirroring physiological regulation of SREBP-1c in vivo.	Fatty Acids, Unsaturated	49-76	sterol regulatory element binding transcription factor 1	Rattus norvegicus	174-182
11905995-4	2002	Cells pretreated with highly oxidizable polyunsaturated fatty acid elevated lipid peroxidation and synergistically exacerbated motor neuron-like cell death with mutant G93A-SOD1 but not with wild-type SOD1.	Fatty Acids, Unsaturated	40-66	superoxide dismutase 1, soluble	Mus musculus	173-177
11905995-4	2002	Cells pretreated with highly oxidizable polyunsaturated fatty acid elevated lipid peroxidation and synergistically exacerbated motor neuron-like cell death with mutant G93A-SOD1 but not with wild-type SOD1.	Fatty Acids, Unsaturated	40-66	superoxide dismutase 1, soluble	Mus musculus	201-205
11834220-0	2002	Polyunsaturated fatty acids downregulate the low density lipoprotein receptor of human HepG2 cells.	Fatty Acids, Unsaturated	0-27	low density lipoprotein receptor	Homo sapiens	45-77
11677241-1	2002	The regulation of stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the synthesis of unsaturated fatty acids, is physiologically important because the ratio of saturated to unsaturated fatty acids is thought to control cellular functions by modulating the structural integrity and fluidity of cell membranes.	Fatty Acids, Unsaturated	92-115	stearoyl-CoA desaturase	Homo sapiens	18-41
11677241-1	2002	The regulation of stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the synthesis of unsaturated fatty acids, is physiologically important because the ratio of saturated to unsaturated fatty acids is thought to control cellular functions by modulating the structural integrity and fluidity of cell membranes.	Fatty Acids, Unsaturated	92-115	stearoyl-CoA desaturase	Homo sapiens	43-46
11677241-1	2002	The regulation of stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the synthesis of unsaturated fatty acids, is physiologically important because the ratio of saturated to unsaturated fatty acids is thought to control cellular functions by modulating the structural integrity and fluidity of cell membranes.	Fatty Acids, Unsaturated	180-203	stearoyl-CoA desaturase	Homo sapiens	18-41
11677241-1	2002	The regulation of stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the synthesis of unsaturated fatty acids, is physiologically important because the ratio of saturated to unsaturated fatty acids is thought to control cellular functions by modulating the structural integrity and fluidity of cell membranes.	Fatty Acids, Unsaturated	180-203	stearoyl-CoA desaturase	Homo sapiens	43-46
11756058-0	2002	Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study.	Fatty Acids, Unsaturated	0-27	apolipoprotein A1	Homo sapiens	56-61
11968005-5	2002	Here we show that the PUFA docosahexaenoic acid (DHA) stimulates PEPCK mRNA in glucose-deprived adipose tissue explants from fed rats and in 3T3-F442A differentiated adipocytes.	Fatty Acids, Unsaturated	22-26	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	65-70
11773501-1	2002	The aim of the present study was to determine whether dietary intake of monounsaturated (MUFA) and/or polyunsaturated fatty acids (PUFA) of the (n- 3) and (n-6) series could improve intestinal damage and reduce inflammation in experimental ulcerative colitis (UC).	Fatty Acids, Unsaturated	102-129	Polyunsaturated fatty acid percentage	Sus scrofa	131-135
12630148-1	2002	Abnormal long chain polyunsaturated fatty acid (LCP) levels are found in children and adults who have several chronic diseases, due to restricted diets or possible abnormalities in metabolic pathways.	Fatty Acids, Unsaturated	20-46	kelch domain containing 2	Homo sapiens	48-51
11902115-8	2002	Since polyunsaturated fatty acids in neurons are mainly supplied by astrocytes, these results revealed a new role for apoE in regulating polyunsaturated phospholipid molecular species in neuronal membranes.	Fatty Acids, Unsaturated	6-33	apolipoprotein E	Mus musculus	118-122
11553616-2	2001	Here we show that recombinant alpha-synuclein forms multimers in vitro upon exposure to vesicles containing certain polyunsaturated fatty acid (PUFA) acyl groups, including arachidonoyl and docosahexaenoyl.	Fatty Acids, Unsaturated	116-142	synuclein alpha	Homo sapiens	30-45
12418799-14	2002	The human brain, like other brains, consists 60% of poly-unsaturated fatty acids (Marine-Fat), the rest being water.	Fatty Acids, Unsaturated	52-80	FAT atypical cadherin 1	Homo sapiens	89-92
11744327-3	2001	Addition of ethanol or an unsaturated fatty acid such as arachidonic acid or iron was toxic to the CYP2E1-expressing cells but not control cells.	Fatty Acids, Unsaturated	26-48	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	99-105
11724940-7	2001	The zebrafish Delta5/Delta6 desaturase may represent a component of a prototypic vertebrate polyunsaturated fatty acids biosynthesis pathway.	Fatty Acids, Unsaturated	92-119	fatty acid desaturase 2	Homo sapiens	27-38
11701434-0	2001	Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARalpha-mediated pathway.	Fatty Acids, Unsaturated	0-27	uncoupling protein 2	Homo sapiens	46-51
11701434-0	2001	Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARalpha-mediated pathway.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Homo sapiens	69-78
11701434-4	2001	Eicosapentaenoic acid (EPA), a polyunsaturated fatty acid, exerted a 50-fold upregulation of UCP-2 that was concentration dependent.	Fatty Acids, Unsaturated	31-57	uncoupling protein 2	Homo sapiens	93-98
11701434-8	2001	These data indicate that UCP-2 is upregulated by polyunsaturated fatty acids, potentially through a prostaglandin/PPARalpha-mediated pathway.	Fatty Acids, Unsaturated	49-76	uncoupling protein 2	Homo sapiens	25-30
11701434-8	2001	These data indicate that UCP-2 is upregulated by polyunsaturated fatty acids, potentially through a prostaglandin/PPARalpha-mediated pathway.	Fatty Acids, Unsaturated	49-76	peroxisome proliferator activated receptor alpha	Homo sapiens	114-123
11742889-9	2001	In conclusion, this study demonstrates that dietary intake of unsaturated fatty acids is positively associated with PAI-1 activity, whereas intake of saturated fatty acids is not.	Fatty Acids, Unsaturated	62-85	serpin family E member 1	Homo sapiens	116-121
11726530-4	2001	UFAs inhibit COX-2 expression induced by SFAs and LPS.	Fatty Acids, Unsaturated	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11726530-5	2001	Additional evidence suggests that both SFA-induced COX-2 expression and its inhibition by UFAs are mediated through a common signaling pathway derived from Tlr4.	Fatty Acids, Unsaturated	90-94	toll like receptor 4	Homo sapiens	156-160
11739012-1	2001	Dietary polyunsaturated fatty acid (PUFA) intake in humans can affect the incidence of a variety of diseases including coronary heart disease.	Fatty Acids, Unsaturated	8-34	PUFA	Bos taurus	36-40
11768809-7	2001	Maternal regulation of the antiluteolytic pathway is discussed relative to the ability of the polyunsaturated fatty acid, eicosapentaenoic (EPA), to decrease endometrial secretion of PGF2alpha and progesterone to increase both conceptus development and IFN-tau secretion.	Fatty Acids, Unsaturated	94-120	interferon-tau-like	Bos taurus	253-260
11557770-12	2001	Under those conditions, Mga2pDeltatm acts as a powerful transcription activator that is strongly repressed by unsaturated fatty acids.	Fatty Acids, Unsaturated	110-133	Mga2p	Saccharomyces cerevisiae S288C	24-28
11734578-3	2001	The present study was designed to examine if the release of fatty acids by hormone-sensitive lipase (HSL) in vitro i) is influenced by the amount of unsaturation, ii) depends on the temperature, and iii) could explain the selective pattern of fatty acid mobilization and notably the preferential mobilization of certain highly unsaturated fatty acids.	Fatty Acids, Unsaturated	327-350	lipase E, hormone sensitive type	Rattus norvegicus	75-99
11734578-3	2001	The present study was designed to examine if the release of fatty acids by hormone-sensitive lipase (HSL) in vitro i) is influenced by the amount of unsaturation, ii) depends on the temperature, and iii) could explain the selective pattern of fatty acid mobilization and notably the preferential mobilization of certain highly unsaturated fatty acids.	Fatty Acids, Unsaturated	327-350	lipase E, hormone sensitive type	Rattus norvegicus	101-104
11734578-12	2001	We conclude that i) the release of fatty acids by HSL is only slightly affected by their degree of unsaturation, ii) the ability of HSL to efficiently and selectively release fatty acids at low temperature could reflect a cold adaptability for poikilotherms or hibernators when endogenous lipids are needed, and iii) the selectivity of fatty acid hydrolysis by HSL does not fully account for the selective pattern of fatty acid mobilization, but could contribute to explain the preferential mobilization of some highly unsaturated fatty acids compared with others.	Fatty Acids, Unsaturated	519-542	lipase E, hormone sensitive type	Rattus norvegicus	132-135
11734578-12	2001	We conclude that i) the release of fatty acids by HSL is only slightly affected by their degree of unsaturation, ii) the ability of HSL to efficiently and selectively release fatty acids at low temperature could reflect a cold adaptability for poikilotherms or hibernators when endogenous lipids are needed, and iii) the selectivity of fatty acid hydrolysis by HSL does not fully account for the selective pattern of fatty acid mobilization, but could contribute to explain the preferential mobilization of some highly unsaturated fatty acids compared with others.	Fatty Acids, Unsaturated	519-542	lipase E, hormone sensitive type	Rattus norvegicus	132-135
11557770-3	2001	OLE1 gene expression is regulated by unsaturated fatty acids, which repress transcription and destabilize the OLE1 mRNA.	Fatty Acids, Unsaturated	37-60	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
11557770-3	2001	OLE1 gene expression is regulated by unsaturated fatty acids, which repress transcription and destabilize the OLE1 mRNA.	Fatty Acids, Unsaturated	37-60	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	110-114
11557770-10	2001	OLE1 expression is strongly repressed by unsaturated fatty acids in spt23Delta or mga2Delta cells, under all growth conditions.	Fatty Acids, Unsaturated	41-64	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
11795852-1	2001	Electrospray/tandem mass spectrometry was used to quantify lipid remodeling in mouse liver and plasma during inhibition of polyunsaturated fatty acid synthesis by the delta6 fatty acid desaturase inhibitor, SC-26196.	Fatty Acids, Unsaturated	123-149	fatty acid desaturase 2	Mus musculus	167-195
11543718-4	2001	PUFAs stimulated the generation of reactive oxygen species (ROS) and activated various types of caspase-like proteases, such as caspase-3, -6, -8, and -9, but not caspase-1.	Fatty Acids, Unsaturated	0-5	caspase 3	Homo sapiens	128-153
11574286-5	2001	These EtOH- and nicotine-induced decreases in brain membrane polyunsaturated fatty acids correlated with elevated levels of brain lipid hydroperoxides and reduced brain acetylcholinesterase (AChE; EC.	Fatty Acids, Unsaturated	61-88	acetylcholinesterase (Cartwright blood group)	Gallus gallus	169-189
11574286-5	2001	These EtOH- and nicotine-induced decreases in brain membrane polyunsaturated fatty acids correlated with elevated levels of brain lipid hydroperoxides and reduced brain acetylcholinesterase (AChE; EC.	Fatty Acids, Unsaturated	61-88	acetylcholinesterase (Cartwright blood group)	Gallus gallus	191-195
11425849-9	2001	This study therefore shows that ZAG binds small hydrophobic ligands, that the natural ligand may be a polyunsaturated fatty acid, and provides a fluorescence-based method for investigating ZAG-ligand interactions.	Fatty Acids, Unsaturated	102-128	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	32-35
11591404-1	2001	OBJECTIVE: To study the effects of omega-3 and omega-6 polyunsaturated fatty acid (PUFA) on in vitro proliferation of endometrial cells and their production of the cytokine interleukin-8 (IL-8).	Fatty Acids, Unsaturated	83-87	C-X-C motif chemokine ligand 8	Homo sapiens	173-186
12447823-8	2001	The exogenous administration of LAC may affect brain activity in FXS by: I) modulation of fuel partitioning for energy production, which at the mithocondrial level is associated with the Kreb"s cycle metabolic role in neurotransmitter synthesis; II) remodelling of lipid membrane in terms of LAC actively determining the production of polyunsaturated fatty acids; III) preferential effect on the attention component of the cholinergic system which relies on its peculiar modality of communication in the CNS.	Fatty Acids, Unsaturated	335-362	lactase	Homo sapiens	32-35
11571758-1	2001	A gene encoding a fatty acid synthase component, FAS1, has been cloned from a genomic library of the polyunsaturated fatty acid (PUFA)-producing yeast Saccharomyces kluyveri.	Fatty Acids, Unsaturated	101-127	tetrafunctional fatty acid synthase subunit FAS1	Saccharomyces cerevisiae S288C	49-53
11571758-1	2001	A gene encoding a fatty acid synthase component, FAS1, has been cloned from a genomic library of the polyunsaturated fatty acid (PUFA)-producing yeast Saccharomyces kluyveri.	Fatty Acids, Unsaturated	129-133	tetrafunctional fatty acid synthase subunit FAS1	Saccharomyces cerevisiae S288C	49-53
11699444-5	2001	Milk, cream, butter, and buttermilk from the fish oil, fish oil with extruded soybean, and extruded soybean diets had higher concentrations of transvaccenic acid and unsaturated fatty acids compared with the controls.	Fatty Acids, Unsaturated	166-189	Weaning weight-maternal milk	Bos taurus	0-4
11728170-1	2001	The ability of surfactant protein A (SP-A) to inhibit the ascorbate-Fe(2+) induced lipid peroxidation of polyunsaturated fatty acids found in porcine lung surfactant (surfacen) was assessed by measuring the light emission - chemiluminescence during a 180-min incubation period at 37 degrees C. The light emission (chemiluminescence) was concentration dependent.	Fatty Acids, Unsaturated	105-132	pulmonary surfactant-associated protein A	Sus scrofa	15-35
11728170-1	2001	The ability of surfactant protein A (SP-A) to inhibit the ascorbate-Fe(2+) induced lipid peroxidation of polyunsaturated fatty acids found in porcine lung surfactant (surfacen) was assessed by measuring the light emission - chemiluminescence during a 180-min incubation period at 37 degrees C. The light emission (chemiluminescence) was concentration dependent.	Fatty Acids, Unsaturated	105-132	pulmonary surfactant-associated protein A	Sus scrofa	37-41
11728170-4	2001	Native SP-A isolated from pig lungs inhibited oxidation of surfactant long chain polyunsaturated fatty acids, mainly arachidonic acid, in a dose-dependent fashion that was half-maximal (60% inhibition) at a concentration of 2.0 microg/ml and almost complete (73.6% inhibition) at 4.0 microg/ml, as indicated by inhibition of light emission and fatty acid composition analysis.	Fatty Acids, Unsaturated	81-108	pulmonary surfactant-associated protein A	Sus scrofa	7-11
11728170-5	2001	At the highest concentration of lung SP-A used a very good correlation between the protection of the most polyunsaturated fatty acids and inhibition of light emission was observed.	Fatty Acids, Unsaturated	106-133	pulmonary surfactant-associated protein A	Sus scrofa	37-41
11415448-9	2001	The polyunsaturated-fatty-acid (PUFA) response element, previously identified in the promoters of mouse Scd1 and Scd2, was found to be conserved in the human SCD promoter, and contained the critical CCAAT cis-element.	Fatty Acids, Unsaturated	32-36	stearoyl-Coenzyme A desaturase 1	Mus musculus	104-108
11509659-3	2001	Previous studies have suggested that the pathway regulating OLE1 expression by unsaturated fatty acids may involve Mga2p and Spt23p, two structurally and functionally related proteins.	Fatty Acids, Unsaturated	79-102	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	60-64
11509659-3	2001	Previous studies have suggested that the pathway regulating OLE1 expression by unsaturated fatty acids may involve Mga2p and Spt23p, two structurally and functionally related proteins.	Fatty Acids, Unsaturated	79-102	Mga2p	Saccharomyces cerevisiae S288C	115-120
11509659-3	2001	Previous studies have suggested that the pathway regulating OLE1 expression by unsaturated fatty acids may involve Mga2p and Spt23p, two structurally and functionally related proteins.	Fatty Acids, Unsaturated	79-102	Spt23p	Saccharomyces cerevisiae S288C	125-131
11523989-1	2001	Protein phosphatase 5 (PP5) exhibits low basal activity due to the autoinhibitory properties of its N-terminal and C-terminal domains but can be activated approximately 40-fold in vitro by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	189-216	protein phosphatase 5 catalytic subunit	Homo sapiens	0-21
11523989-1	2001	Protein phosphatase 5 (PP5) exhibits low basal activity due to the autoinhibitory properties of its N-terminal and C-terminal domains but can be activated approximately 40-fold in vitro by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	189-216	protein phosphatase 5 catalytic subunit	Homo sapiens	23-26
11500179-1	2001	Oxidized lipoproteins inhibit TNF-alpha secretion by human THP-1 macrophages due, at least in part, to aldehydes derived from the oxidation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	143-170	tumor necrosis factor	Homo sapiens	30-39
11500179-1	2001	Oxidized lipoproteins inhibit TNF-alpha secretion by human THP-1 macrophages due, at least in part, to aldehydes derived from the oxidation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	143-170	GLI family zinc finger 2	Homo sapiens	59-64
11522616-7	2001	A novel approach for cancer chemoprevention would involve LOX modulators, i.e., agents that can induce the anticarcinogenic and/or inhibit the procarcinogenic LOXs, thereby shifting the balance of LOX activities from procarcinogenic to anticarcinogenic metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	267-294	lysyl oxidase	Homo sapiens	58-61
11423543-0	2001	Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction.	Fatty Acids, Unsaturated	57-84	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	33-36
11423543-7	2001	Modification of Fyn with unsaturated or polyunsaturated fatty acids reduced its raft localization and resulted in decreased T cell signal transduction.	Fatty Acids, Unsaturated	40-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	16-19
11395520-8	2001	Under these conditions, lyso-PS with unsaturated fatty acid was released from the apoptotic cells treated with PS-PLA(1).	Fatty Acids, Unsaturated	37-59	phospholipase A1 member A	Rattus norvegicus	111-120
11397803-2	2001	The regulation of SCD is of physiological importance because the ratio of saturated fatty acids to unsaturated fatty acids is thought to modulate membrane fluidity.	Fatty Acids, Unsaturated	99-122	stearoyl-CoA desaturase	Homo sapiens	18-21
11592738-1	2001	Lipoxygenase (LOX) is an enzyme that oxygenates polyunsaturated fatty acids to their corresponding hydroperoxy derivatives.	Fatty Acids, Unsaturated	48-75	linoleate 9S-lipoxygenase-4	Glycine max	0-12
11592738-1	2001	Lipoxygenase (LOX) is an enzyme that oxygenates polyunsaturated fatty acids to their corresponding hydroperoxy derivatives.	Fatty Acids, Unsaturated	48-75	linoleate 9S-lipoxygenase-4	Glycine max	14-17
11333258-9	2001	Finally, SCP-2 expression selectively altered the pattern of esterified fatty acids in favor of polyunsaturated fatty acids within the lipid droplet.	Fatty Acids, Unsaturated	96-123	sterol carrier protein 2	Homo sapiens	9-14
11415460-11	2001	Unsaturated fatty acids inhibited growth-factor-induced DGKalpha activation, but had no effect on basal activity.	Fatty Acids, Unsaturated	0-23	diacylglycerol kinase alpha	Homo sapiens	56-64
11415448-9	2001	The polyunsaturated-fatty-acid (PUFA) response element, previously identified in the promoters of mouse Scd1 and Scd2, was found to be conserved in the human SCD promoter, and contained the critical CCAAT cis-element.	Fatty Acids, Unsaturated	32-36	stearoyl-Coenzyme A desaturase 2	Mus musculus	113-117
11415448-9	2001	The polyunsaturated-fatty-acid (PUFA) response element, previously identified in the promoters of mouse Scd1 and Scd2, was found to be conserved in the human SCD promoter, and contained the critical CCAAT cis-element.	Fatty Acids, Unsaturated	32-36	stearoyl-CoA desaturase	Homo sapiens	158-161
11418687-0	2001	Gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, blocks amplification of IL-1 beta production by human monocytes.	Fatty Acids, Unsaturated	24-46	interleukin 1 beta	Homo sapiens	106-115
11278959-4	2001	Ex vivo experiments on human skin tissue sections have shown that micromolar concentrations of a long-chain unsaturated fatty acid (elaidic acid) protect collagen and elastin fibers against degradation by gelatinases A and B, respectively.	Fatty Acids, Unsaturated	108-130	elastin	Homo sapiens	167-174
11414710-0	2001	Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol.	Fatty Acids, Unsaturated	171-198	stearoyl-CoA desaturase	Homo sapiens	42-65
11414710-5	2001	Polyunsaturated fatty acids and cholesterol decreased the SCD promoter-luciferase activity when transiently transfected into HepG2 cells.	Fatty Acids, Unsaturated	0-27	stearoyl-CoA desaturase	Homo sapiens	58-61
11414710-8	2001	Our studies indicate that the transcription of the human SCD gene is repressed by polyunsaturated fatty acids and cholesterol and that SREBP plays a role in the transcriptional activation of this gene.	Fatty Acids, Unsaturated	82-109	stearoyl-CoA desaturase	Homo sapiens	57-60
11418678-5	2001	More importantly, the GPI anchors purified from T. cruzi trypomastigotes, which contain a longer glycan core and unsaturated fatty acids in the sn-2 position of the alkylacylglycerolipid component, triggered TLR-2 at subnanomolar concentrations.	Fatty Acids, Unsaturated	113-136	toll-like receptor 2	Mus musculus	208-213
11458177-10	2001	At last it seems that polyunsaturated fatty acids could activate LXRalpha transcription through its activation by PPARalpha.	Fatty Acids, Unsaturated	22-49	nuclear receptor subfamily 1, group H, member 3	Mus musculus	65-73
11458177-10	2001	At last it seems that polyunsaturated fatty acids could activate LXRalpha transcription through its activation by PPARalpha.	Fatty Acids, Unsaturated	22-49	peroxisome proliferator activated receptor alpha	Mus musculus	114-123
11278875-1	2001	The enzyme 12/15-lipoxygenase (12/15-LO) introduces peroxyl groups in a position-specific manner into unsaturated fatty acids in certain cells, but the role of such enzymatic lipid peroxidation remains poorly defined.	Fatty Acids, Unsaturated	102-125	arachidonate 15-lipoxygenase	Mus musculus	11-29
11353336-6	2001	More specifically, it has been demonstrated that polyunsaturated fatty acid (PUFA) intake influences adipose tissue expression of leptin, and of several lipogenic enzymes and transcription factors.	Fatty Acids, Unsaturated	49-75	leptin	Homo sapiens	130-136
11353336-6	2001	More specifically, it has been demonstrated that polyunsaturated fatty acid (PUFA) intake influences adipose tissue expression of leptin, and of several lipogenic enzymes and transcription factors.	Fatty Acids, Unsaturated	77-81	leptin	Homo sapiens	130-136
11278875-1	2001	The enzyme 12/15-lipoxygenase (12/15-LO) introduces peroxyl groups in a position-specific manner into unsaturated fatty acids in certain cells, but the role of such enzymatic lipid peroxidation remains poorly defined.	Fatty Acids, Unsaturated	102-125	arachidonate 15-lipoxygenase	Mus musculus	31-39
11485159-4	2001	Feeding maritime pine (Pinus pinaster) seed oil (MPO) diet with a delta5 PMI-PUFA content of 1.4 g/100 g throughout pregnancy and lactation resulted in a large incorporation of delta5 PMI-PUFA in mothers" milk (5.1 +/- 0.5% of total fatty acids).	Fatty Acids, Unsaturated	77-81	myeloperoxidase	Rattus norvegicus	49-52
11278967-6	2001	UFAs inhibit COX-2 expression induced by SFAs, constitutively active Tlr4, or LPS.	Fatty Acids, Unsaturated	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11371634-0	2001	Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.	Fatty Acids, Unsaturated	0-23	sterol regulatory element binding transcription factor 1	Homo sapiens	53-97
11371634-0	2001	Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.	Fatty Acids, Unsaturated	0-23	sterol regulatory element binding transcription factor 1	Homo sapiens	99-107
11371634-1	2001	Sterol regulatory element-binding protein-1c (SREBP-1c) enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis in liver.	Fatty Acids, Unsaturated	108-130	sterol regulatory element binding transcription factor 1	Homo sapiens	0-44
11371634-1	2001	Sterol regulatory element-binding protein-1c (SREBP-1c) enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis in liver.	Fatty Acids, Unsaturated	108-130	sterol regulatory element binding transcription factor 1	Homo sapiens	46-54
11371634-2	2001	SREBP-1c mRNA is known to increase when cells are treated with agonists of liver X receptor (LXR), a nuclear hormone receptor, and to decrease when cells are treated with unsaturated fatty acids, the end products of SREBP-1c action.	Fatty Acids, Unsaturated	171-194	sterol regulatory element binding transcription factor 1	Homo sapiens	0-8
11371634-2	2001	SREBP-1c mRNA is known to increase when cells are treated with agonists of liver X receptor (LXR), a nuclear hormone receptor, and to decrease when cells are treated with unsaturated fatty acids, the end products of SREBP-1c action.	Fatty Acids, Unsaturated	171-194	sterol regulatory element binding transcription factor 1	Homo sapiens	216-224
11371634-3	2001	Here we show that unsaturated fatty acids lower SREBP-1c mRNA levels in part by antagonizing the actions of LXR.	Fatty Acids, Unsaturated	18-41	sterol regulatory element binding transcription factor 1	Homo sapiens	48-56
11278967-6	2001	UFAs inhibit COX-2 expression induced by SFAs, constitutively active Tlr4, or LPS.	Fatty Acids, Unsaturated	0-4	toll like receptor 4	Homo sapiens	69-73
11278967-8	2001	Together, these results suggest that both SFA-induced COX-2 expression and its inhibition by UFAs are mediated through a common signaling pathway derived from Tlr4.	Fatty Acids, Unsaturated	93-97	toll like receptor 4	Homo sapiens	159-163
11352981-3	2001	A 3-week n-3 PUFA-enriched diet, as compared with a 3-week lard-enriched diet, induced lower plasma leptin concentration and reduced leptin mRNA expression in rat epididymal adipose tissue.	Fatty Acids, Unsaturated	13-17	leptin	Rattus norvegicus	100-106
11352981-0	2001	Reduction of leptin gene expression by dietary polyunsaturated fatty acids.	Fatty Acids, Unsaturated	47-74	leptin	Homo sapiens	13-19
11352981-3	2001	A 3-week n-3 PUFA-enriched diet, as compared with a 3-week lard-enriched diet, induced lower plasma leptin concentration and reduced leptin mRNA expression in rat epididymal adipose tissue.	Fatty Acids, Unsaturated	13-17	leptin	Rattus norvegicus	133-139
11352654-7	2001	Taken together, the results suggest that the increase in linolenic acid content in cells containing Fad3 was not due to enhanced physiological demand for polyunsaturated fatty acids by yeast, but rather a cold-inducible, post-transcriptional increase in steady-state amount of plant desaturase enzyme.	Fatty Acids, Unsaturated	154-181	omega-3 fatty acid desaturase, endoplasmic reticulum-like	Brassica napus	100-104
11388772-3	2001	Supraphysiological concentrations of gamma-linolenic acid and some other polyunsaturated fatty acids (PUFAs) therefore suppress glycolysis but also inhibit FFA oxidation initiated through a cytochrome P450-mediated epoxidation of PUFA to inhibit fatty acid synthase (FAS) activity.	Fatty Acids, Unsaturated	73-100	pumilio RNA binding family member 3	Homo sapiens	102-106
11388772-3	2001	Supraphysiological concentrations of gamma-linolenic acid and some other polyunsaturated fatty acids (PUFAs) therefore suppress glycolysis but also inhibit FFA oxidation initiated through a cytochrome P450-mediated epoxidation of PUFA to inhibit fatty acid synthase (FAS) activity.	Fatty Acids, Unsaturated	73-100	fatty acid synthase	Homo sapiens	246-265
11388772-3	2001	Supraphysiological concentrations of gamma-linolenic acid and some other polyunsaturated fatty acids (PUFAs) therefore suppress glycolysis but also inhibit FFA oxidation initiated through a cytochrome P450-mediated epoxidation of PUFA to inhibit fatty acid synthase (FAS) activity.	Fatty Acids, Unsaturated	73-100	fatty acid synthase	Homo sapiens	267-270
11388772-3	2001	Supraphysiological concentrations of gamma-linolenic acid and some other polyunsaturated fatty acids (PUFAs) therefore suppress glycolysis but also inhibit FFA oxidation initiated through a cytochrome P450-mediated epoxidation of PUFA to inhibit fatty acid synthase (FAS) activity.	Fatty Acids, Unsaturated	102-107	fatty acid synthase	Homo sapiens	246-265
11388772-3	2001	Supraphysiological concentrations of gamma-linolenic acid and some other polyunsaturated fatty acids (PUFAs) therefore suppress glycolysis but also inhibit FFA oxidation initiated through a cytochrome P450-mediated epoxidation of PUFA to inhibit fatty acid synthase (FAS) activity.	Fatty Acids, Unsaturated	102-107	fatty acid synthase	Homo sapiens	267-270
11328947-5	2001	Furthermore, PUFA reduced plasma endotoxemia at 48 h (25 +/- 4 EU/mL versus 276 +/- 39 EU/mL in control and 170 +/- 28 EU/mL in PUFA + nucleotide), intestinal phospholipase A(2)-II expression at 24 h, and platelet activating factor receptor expression at 48 h. Formula supplementation had no effect on apoptosis of intestinal epithelium or intestinal inducible nitric oxide synthase expression.	Fatty Acids, Unsaturated	13-17	nitric oxide synthase 2	Rattus norvegicus	351-382
11278377-2	2001	We have identified, at least in part, the mechanism by which polyunsaturated fatty acids increase UCP-2 expression in primary culture of human muscle cells.	Fatty Acids, Unsaturated	61-88	uncoupling protein 2	Homo sapiens	98-103
11272021-7	2001	Pancreatic lipase appeared more efficient with beef fat than pork fat, possibly because beef fat contains less polyunsaturated fatty acids than pork fat.	Fatty Acids, Unsaturated	111-138	pancreatic lipase	Homo sapiens	0-17
11275473-1	2001	Polyunsaturated fatty acids such as arachidonic acid were previously shown to be toxic to HepG2 cells expressing CYP2E1 by a mechanism involving oxidative stress and lipid peroxidation.	Fatty Acids, Unsaturated	0-27	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	113-119
11403653-0	2001	Acylation of Bowman-Birk soybean proteinase inhibitor by unsaturated fatty acid derivatives.	Fatty Acids, Unsaturated	57-79	Bowman-Birk type proteinase inhibitor	Glycine max	13-53
11361338-11	2001	HRL occurs at the C-terminus of the peroxisomal protein Eci1p, which is required for growth on unsaturated fatty acids.	Fatty Acids, Unsaturated	95-118	dodecenoyl-CoA isomerase	Saccharomyces cerevisiae S288C	56-61
11259624-5	2001	Addition of a polyunsaturated fatty acid such as arachidonic acid (AA) to HepG2 cells resulted in loss of cell viability, especially in cells expressing CYP2E1 (E47 cells).	Fatty Acids, Unsaturated	14-40	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	153-159
11383698-1	2001	Unsaturated fatty acids with triple bonds are used as inhibitors of unsaturated fatty acid metabolism or cytochrome P450 reactions because they are believed to be chemically inert.	Fatty Acids, Unsaturated	0-23	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	105-120
11383698-2	2001	In this paper we use in vitro cytochrome C reduction to show that two commonly used triple-bonded unsaturated fatty acids are in fact potent electron transfer agents and could affect the multiple cellular systems that are redox-modulated.	Fatty Acids, Unsaturated	98-121	cytochrome c, somatic	Homo sapiens	30-42
11085986-4	2001	In the current experiments, unsaturated fatty acids decreased the nuclear content of SREBP-1, but not SREBP-2, in cultured human embryonic kidney (HEK)-293 cells.	Fatty Acids, Unsaturated	28-51	sterol regulatory element binding transcription factor 1	Homo sapiens	85-92
11278167-13	2001	The fact that the expression and activity of SCD1, an enzyme adding a double bound into saturated fatty acids, are induced in two models of iron overload in mice leads to the conclusion that iron excess in the liver may enhance the biosynthesis of unsaturated fatty acids.	Fatty Acids, Unsaturated	248-271	stearoyl-Coenzyme A desaturase 1	Mus musculus	45-49
11299072-8	2001	The polyunsaturated fatty acids (PUFA) include the n-3 compounds, some of which are precursors of eicosanoid synthesis, and the n-6 group which can increase formation of the pro-inflammatory cytokines TNFalpha and interleukin-6, and of reactive oxygen species.	Fatty Acids, Unsaturated	4-31	tumor necrosis factor	Homo sapiens	201-209
11299072-8	2001	The polyunsaturated fatty acids (PUFA) include the n-3 compounds, some of which are precursors of eicosanoid synthesis, and the n-6 group which can increase formation of the pro-inflammatory cytokines TNFalpha and interleukin-6, and of reactive oxygen species.	Fatty Acids, Unsaturated	4-31	interleukin 6	Homo sapiens	214-227
11299072-8	2001	The polyunsaturated fatty acids (PUFA) include the n-3 compounds, some of which are precursors of eicosanoid synthesis, and the n-6 group which can increase formation of the pro-inflammatory cytokines TNFalpha and interleukin-6, and of reactive oxygen species.	Fatty Acids, Unsaturated	33-37	tumor necrosis factor	Homo sapiens	201-209
11299072-8	2001	The polyunsaturated fatty acids (PUFA) include the n-3 compounds, some of which are precursors of eicosanoid synthesis, and the n-6 group which can increase formation of the pro-inflammatory cytokines TNFalpha and interleukin-6, and of reactive oxygen species.	Fatty Acids, Unsaturated	33-37	interleukin 6	Homo sapiens	214-227
11642042-1	2001	5-lipoxygenase (EC 1.13.11.12) oxidizes polyunsaturated fatty acids by molecular oxygen.	Fatty Acids, Unsaturated	40-67	5-lipoxygenase	Solanum tuberosum	0-14
11239826-9	2001	These results demonstrate that PLDalpha and at least one other PLD isoform, as well as other hydrolytic enzymes, are active in mechanically wounded Arabidopsis leaves, and PLDalpha is involved in wound-induced metabolism of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	224-251	phospholipase D alpha 1	Arabidopsis thaliana	31-34
11124951-0	2001	Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Rattus norvegicus	45-88
11124951-1	2001	The reduction in hepatic abundance of sterol regulatory element binding protein-1 (SREBP-1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA) appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene transcription.	Fatty Acids, Unsaturated	142-169	sterol regulatory element binding transcription factor 1	Rattus norvegicus	38-81
11124951-1	2001	The reduction in hepatic abundance of sterol regulatory element binding protein-1 (SREBP-1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA) appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene transcription.	Fatty Acids, Unsaturated	142-169	sterol regulatory element binding transcription factor 1	Rattus norvegicus	83-90
11124951-1	2001	The reduction in hepatic abundance of sterol regulatory element binding protein-1 (SREBP-1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA) appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene transcription.	Fatty Acids, Unsaturated	171-175	sterol regulatory element binding transcription factor 1	Rattus norvegicus	38-81
11124951-1	2001	The reduction in hepatic abundance of sterol regulatory element binding protein-1 (SREBP-1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA) appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene transcription.	Fatty Acids, Unsaturated	171-175	sterol regulatory element binding transcription factor 1	Rattus norvegicus	83-90
11181943-2	2001	The brain incorporation of [(3)H]arachidonic acid ([(3)H]AA), a polyunsaturated fatty acid, may reflect regional changes in neurotransmitter signal transduction using phospholipase A(2).	Fatty Acids, Unsaturated	64-90	phospholipase A2 group IB	Rattus norvegicus	167-184
11085986-9	2001	When SREBP-1a was produced by a cDNA expressed from an independent promoter, unsaturated fatty acids reduced nuclear SREBP-1a without affecting the mRNA level.	Fatty Acids, Unsaturated	77-100	sterol regulatory element binding transcription factor 1	Homo sapiens	5-13
11085986-9	2001	When SREBP-1a was produced by a cDNA expressed from an independent promoter, unsaturated fatty acids reduced nuclear SREBP-1a without affecting the mRNA level.	Fatty Acids, Unsaturated	77-100	sterol regulatory element binding transcription factor 1	Homo sapiens	117-125
11085986-11	2001	When administered together, sterols and unsaturated fatty acids potentiated each other in reducing nuclear SREBP-1.	Fatty Acids, Unsaturated	40-63	sterol regulatory element binding transcription factor 1	Homo sapiens	107-114
11085986-13	2001	We conclude that unsaturated fatty acids, as well as sterols, can down-regulate nuclear SREBPs and that unsaturated fatty acids have their greatest inhibitory effects on SREBP-1a and SREBP-1c, whereas sterols have their greatest inhibitory effects on SREBP-2.	Fatty Acids, Unsaturated	104-127	sterol regulatory element binding transcription factor 1	Homo sapiens	170-178
11085986-13	2001	We conclude that unsaturated fatty acids, as well as sterols, can down-regulate nuclear SREBPs and that unsaturated fatty acids have their greatest inhibitory effects on SREBP-1a and SREBP-1c, whereas sterols have their greatest inhibitory effects on SREBP-2.	Fatty Acids, Unsaturated	104-127	sterol regulatory element binding transcription factor 1	Homo sapiens	183-191
11085986-13	2001	We conclude that unsaturated fatty acids, as well as sterols, can down-regulate nuclear SREBPs and that unsaturated fatty acids have their greatest inhibitory effects on SREBP-1a and SREBP-1c, whereas sterols have their greatest inhibitory effects on SREBP-2.	Fatty Acids, Unsaturated	104-127	sterol regulatory element binding transcription factor 2	Homo sapiens	251-258
11233018-4	2001	Milk from cows fed fish oil contained higher concentrations of conjugated linoleic acid, transvaccenic acid, and total unsaturated fatty acids (0.68 and 2.51; 1.42 and 6.28; and 30.47 and 41.71 g/100 g of fat, respectively).	Fatty Acids, Unsaturated	119-142	Weaning weight-maternal milk	Bos taurus	0-4
11164737-10	2001	CYP2E1-induced lipid peroxidation might play a major role in lipid metabolism, PPARalpha only becomes important when the CYP2E1 level is low and polyunsaturated fatty acids increase.	Fatty Acids, Unsaturated	145-172	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	0-6
11164737-10	2001	CYP2E1-induced lipid peroxidation might play a major role in lipid metabolism, PPARalpha only becomes important when the CYP2E1 level is low and polyunsaturated fatty acids increase.	Fatty Acids, Unsaturated	145-172	peroxisome proliferator activated receptor alpha	Mus musculus	79-88
11302517-1	2001	Saccharomyces cerevisiae delta3,delta2-enoyl-CoA isomerase (Eci1p), encoded by ECI1, is an essential enzyme for the betaoxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	133-156	dodecenoyl-CoA isomerase	Saccharomyces cerevisiae S288C	60-65
11302517-1	2001	Saccharomyces cerevisiae delta3,delta2-enoyl-CoA isomerase (Eci1p), encoded by ECI1, is an essential enzyme for the betaoxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	133-156	dodecenoyl-CoA isomerase	Saccharomyces cerevisiae S288C	79-83
11164737-2	2001	Previously, we have shown that the ethanol-induced CYP2E1 expression in rat is accompanied by the inhibition of the expression of the PPARalpha gene and the reduction in polyunsaturated fatty acid content.	Fatty Acids, Unsaturated	170-196	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	51-57
11233018-5	2001	Butter made from the fish oil diet milk also had higher concentrations of conjugated linoleic acid, transvaccenic acid, and unsaturated fatty acids.	Fatty Acids, Unsaturated	124-147	Weaning weight-maternal milk	Bos taurus	35-39
11161812-7	2001	The promoter sequence of Scd3 reveals similarity with Scd1 in the proximal region but also possesses several distinctive features including the polyunsaturated fatty acid-response element.	Fatty Acids, Unsaturated	144-170	stearoyl-coenzyme A desaturase 3	Mus musculus	25-29
11163536-5	2001	The slow-flow technique allowed us to obtain well-resolved ESR spectra of PUFA-derived radical adducts in a mixture of soybean lipoxygenase, PUFA, and the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO).	Fatty Acids, Unsaturated	74-78	linoleate 9S-lipoxygenase-4	Glycine max	127-139
11162472-0	2001	Effects of polyunsaturated fatty acids and clofibrate on chicken stearoyl-coA desaturase 1 gene expression.	Fatty Acids, Unsaturated	11-38	stearoyl-CoA desaturase	Gallus gallus	65-90
11787705-1	2001	The need for long-chain polyunsaturated fatty acids (LC-PUFA), such as docosahexaenoic acid (DHA, C22:6n3) and arachidonic acid (AA, C20:4n6), in the diet of infants in order to achieve full developmental potential is a matter of intense investigation by several research groups worldwide.	Fatty Acids, Unsaturated	24-51	pumilio RNA binding family member 3	Homo sapiens	56-60
11208657-10	2001	Increased intake of certain polyunsaturated fatty acids might further stimulate IgE production in boys.	Fatty Acids, Unsaturated	28-55	immunoglobulin heavy constant epsilon	Homo sapiens	80-83
11136854-2	2001	TrpL was activated by receptor stimulation and by exogenous application of diacylglycerol (DAG) or poly-unsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	99-127	transient receptor potential-like	Drosophila melanogaster	0-4
11588988-3	2001	Carnitine and polyunsaturated fatty acids have been reported to be reduced in NCL English Setters.	Fatty Acids, Unsaturated	14-41	nucleolin	Canis lupus familiaris	78-81
11395411-1	2001	The nuclear peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcription factor that is activated by polyunsaturated fatty acids and their metabolites and is essential for fat cell formation.	Fatty Acids, Unsaturated	121-148	peroxisome proliferator activated receptor gamma	Homo sapiens	12-60
11395411-1	2001	The nuclear peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcription factor that is activated by polyunsaturated fatty acids and their metabolites and is essential for fat cell formation.	Fatty Acids, Unsaturated	121-148	peroxisome proliferator activated receptor gamma	Homo sapiens	62-72
11133970-0	2001	O2R, a novel regulatory element mediating Rox1p-independent O(2) and unsaturated fatty acid repression of OLE1 in Saccharomyces cerevisiae.	Fatty Acids, Unsaturated	69-91	Rox1p	Saccharomyces cerevisiae S288C	42-47
11133970-0	2001	O2R, a novel regulatory element mediating Rox1p-independent O(2) and unsaturated fatty acid repression of OLE1 in Saccharomyces cerevisiae.	Fatty Acids, Unsaturated	69-91	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	106-110
11133970-7	2001	Anaerobic derepression of OLE1 transcription was repressed by unsaturated fatty acids (UFAs), and interestingly the O2R element was responsible for this UFA repression despite not being included within the fatty acid-regulated (FAR) element previously reported.	Fatty Acids, Unsaturated	62-85	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	26-30
11133970-7	2001	Anaerobic derepression of OLE1 transcription was repressed by unsaturated fatty acids (UFAs), and interestingly the O2R element was responsible for this UFA repression despite not being included within the fatty acid-regulated (FAR) element previously reported.	Fatty Acids, Unsaturated	87-91	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	26-30
11133970-7	2001	Anaerobic derepression of OLE1 transcription was repressed by unsaturated fatty acids (UFAs), and interestingly the O2R element was responsible for this UFA repression despite not being included within the fatty acid-regulated (FAR) element previously reported.	Fatty Acids, Unsaturated	87-90	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	26-30
16233000-6	2001	Using the PHO5 gene fusion as a reporter, we have identified several cis- and trans-acting genes of S. cerevisiae which are involved in splicing of pre-mRNA, biosynthesis of amino acids, ubiquitin-dependent protein degradation, signal transduction of oxygen and unsaturated fatty acid, regulation of transcription by the nucleosome and chromatin.	Fatty Acids, Unsaturated	262-284	acid phosphatase PHO5	Saccharomyces cerevisiae S288C	10-14
11136854-2	2001	TrpL was activated by receptor stimulation and by exogenous application of diacylglycerol (DAG) or poly-unsaturated fatty acids (PUFAs).	Fatty Acids, Unsaturated	129-134	transient receptor potential-like	Drosophila melanogaster	0-4
12092155-4	2001	Scientific data revealed that LDL oxidation is mediated by peroxinitrite (ONOO) anion which could act directly over the thiol groups or indirectly through OH and NO radicals from peroxinitrous acid breakdown and who initiate the polyunsaturated fatty acids peroxidation and the oxidation of apolipoprotein B-100.	Fatty Acids, Unsaturated	229-256	apolipoprotein B	Homo sapiens	291-311
11172467-5	2001	Moreover, with treatment of monounsaturated and polyunsaturated fatty acids (PUFA), the CuZn-SOD mRNA levels were positively correlated with PPARalpha mRNA levels (r = .872, P &lt; .0001) in primary endothelial cells.	Fatty Acids, Unsaturated	48-75	peroxisome proliferator activated receptor alpha	Homo sapiens	141-150
11172467-5	2001	Moreover, with treatment of monounsaturated and polyunsaturated fatty acids (PUFA), the CuZn-SOD mRNA levels were positively correlated with PPARalpha mRNA levels (r = .872, P &lt; .0001) in primary endothelial cells.	Fatty Acids, Unsaturated	77-81	peroxisome proliferator activated receptor alpha	Homo sapiens	141-150
11171151-1	2000	In order to define the substrate requirements, regiochemistry and cryptoregiochemistry of the omega-3 fatty acid desaturases involved in polyunsaturated fatty acid formation, the genes Fad3 and fat-1 from Brassica napus and the nematode Caenorhabditis elegans respectively were expressed in baker"s yeast (Saccharomyces cerevisiae).	Fatty Acids, Unsaturated	137-163	omega-3 fatty acid desaturase, endoplasmic reticulum	Brassica napus	185-189
11302200-7	2001	(4) The content of unsaturated fatty acids in microsomal lipids was decreased by almost 50% after incubation with CCl4, while saturated fatty acids increased slightly.	Fatty Acids, Unsaturated	19-42	C-C motif chemokine ligand 4	Rattus norvegicus	114-118
11118820-6	2000	Other proaging effects of insulin involve the inhibition of proteasome and the stimulation of polyunsaturated fatty acid (PUFA) synthesis and of nitric oxide (NO).	Fatty Acids, Unsaturated	94-120	insulin	Homo sapiens	26-33
11118820-6	2000	Other proaging effects of insulin involve the inhibition of proteasome and the stimulation of polyunsaturated fatty acid (PUFA) synthesis and of nitric oxide (NO).	Fatty Acids, Unsaturated	122-126	insulin	Homo sapiens	26-33
11242473-5	2000	Indeed, dietary fat (especially unsaturated fatty acids) has been shown to induce CRBPII gene expression in the jejunum.	Fatty Acids, Unsaturated	32-55	retinol binding protein 2	Rattus norvegicus	82-88
11149279-7	2000	As one important aspect if skeletal muscle has a high capacity for lipid oxidation, then more saturated fatty acids are oxidised and more unsaturated fatty acids are built in the phospholipid fraction of the plasma membrane, giving it more fluidity and improved insulin sensitivity.	Fatty Acids, Unsaturated	138-161	insulin	Homo sapiens	262-269
11061990-3	2000	Physiological concentrations of each class of polyunsaturated fatty acid and the monounsaturated fatty acid dramatically up-regulated UCP2 mRNA levels 5- to 8-fold, but the saturated fatty acid was not so effective (1.5-fold).	Fatty Acids, Unsaturated	46-72	uncoupling protein 2	Homo sapiens	134-138
11061990-6	2000	In conclusion, dietary unsaturated fatty acids may be physiological signals to alter energy balance by direct induction of UCP2.	Fatty Acids, Unsaturated	23-46	uncoupling protein 2	Homo sapiens	123-127
11063437-1	2000	BACKGROUND: Polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) have been shown to positively affect blood lipids; however, their comparative effects on insulin sensitivity are unclear.	Fatty Acids, Unsaturated	41-46	insulin	Homo sapiens	177-184
11204450-8	2000	Transforming growth factor beta (TGFbeta), polyunsaturated fatty acids and the glucose-insulin-potassium regimen can antagonize the harmful actions of TNFalpha and protect the myocardium.	Fatty Acids, Unsaturated	43-70	tumor necrosis factor	Homo sapiens	151-159
11343966-3	2000	Polyunsaturated fatty acids inhibit hepatic lipogenic enzymes through suppressing SREBP-1.	Fatty Acids, Unsaturated	0-27	sterol regulatory element binding transcription factor 1	Mus musculus	82-89
10995893-2	2000	In this study, bivariate annexin V/PI flow cytometry showed that dietary polyunsaturated fatty acids, arachidonic acid (AA) and eicosapentaenoic acid (EPA), induced apoptosis in human leukemic HL-60 but not K-562 cells.	Fatty Acids, Unsaturated	73-100	annexin A5	Homo sapiens	25-34
11007476-5	2000	SPT23 and MGA2 are relatives of mammalian NF-kappaB and control unsaturated fatty acid levels.	Fatty Acids, Unsaturated	64-86	Spt23p	Saccharomyces cerevisiae S288C	0-5
10880510-0	2000	Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.	Fatty Acids, Unsaturated	83-110	potassium two pore domain channel subfamily K member 10	Homo sapiens	6-11
11007476-5	2000	SPT23 and MGA2 are relatives of mammalian NF-kappaB and control unsaturated fatty acid levels.	Fatty Acids, Unsaturated	64-86	Mga2p	Saccharomyces cerevisiae S288C	10-14
11007531-1	2000	Oxidized metabolites of polyunsaturated fatty acids produced by lipoxygenase are among the endogenous regulators of Na+/K+-ATPase.	Fatty Acids, Unsaturated	24-51	linoleate 9S-lipoxygenase-4	Glycine max	64-76
10941873-8	2000	L-FABP expression generally increased polyunsaturated fatty acids, primarily by increasing 20:4n-6 and 22:6n-3, while decreasing 18:1n-9 and 16:1n-7.	Fatty Acids, Unsaturated	38-65	fatty acid binding protein 1	Homo sapiens	0-6
10854433-6	2000	In this context, analysis of the primary and tertiary structures of human B-FABP provides a rationale for its high affinity and specificity for polyunsaturated fatty acids.	Fatty Acids, Unsaturated	144-171	fatty acid binding protein 7	Homo sapiens	74-80
10989158-3	2000	These observations were associated with changes in the proportions of the major C18, C20 and C22 polyunsaturated fatty acids expressed in all the major lipid fractions and were accompanied by alterations in lipid composition.	Fatty Acids, Unsaturated	97-124	Sp7 transcription factor 7	Mus musculus	93-96
10880966-5	2000	FAT1 is essential for growth under hypoxic conditions and when cerulenin was included in the culture media in the presence or absence of unsaturated fatty acids.	Fatty Acids, Unsaturated	137-160	long-chain fatty acid transporter FAT1	Saccharomyces cerevisiae S288C	0-4
10869364-6	2000	It has been hypothesized that unsaturated fatty acids, by enhancing ACAT activity, reduce the amount of free cholesterol in a putative regulatory pool that feeds back on LDL receptor expression.	Fatty Acids, Unsaturated	30-53	sterol O-acyltransferase 2	Mus musculus	68-72
10869364-6	2000	It has been hypothesized that unsaturated fatty acids, by enhancing ACAT activity, reduce the amount of free cholesterol in a putative regulatory pool that feeds back on LDL receptor expression.	Fatty Acids, Unsaturated	30-53	low density lipoprotein receptor	Mus musculus	170-182
10936025-11	2000	Furthermore, the structural modification and the generation of immunogenic epitopes on beta2GPI upon interaction with CL(N)require the presence of unsaturated fatty acid chains, suggesting a role for oxidation in this process.	Fatty Acids, Unsaturated	147-169	apolipoprotein H	Mus musculus	87-95
10972869-2	2000	The synthesis of these oxylipins was hypothesized to be initiated by the phospholipase A2-mediated release of unsaturated fatty acids from membrane lipids.	Fatty Acids, Unsaturated	110-133	phospholipase A2 group IB	Homo sapiens	73-89
10850979-3	2000	Synthesis of C16:1Delta(11) was dependent on a functional ELO1 gene, indicating that Elo1p catalyzes carboxy-terminal elongation of unsaturated fatty acids (alpha-elongation).	Fatty Acids, Unsaturated	132-155	fatty acid elongase ELO1	Saccharomyces cerevisiae S288C	58-62
10850979-3	2000	Synthesis of C16:1Delta(11) was dependent on a functional ELO1 gene, indicating that Elo1p catalyzes carboxy-terminal elongation of unsaturated fatty acids (alpha-elongation).	Fatty Acids, Unsaturated	132-155	fatty acid elongase ELO1	Saccharomyces cerevisiae S288C	85-90
10806298-0	2000	Effect of omega-6 polyunsaturated fatty acid (linoleic acid) on BRCA1 gene expression in MCF-7 cell line.	Fatty Acids, Unsaturated	18-44	BRCA1 DNA repair associated	Homo sapiens	64-69
10832093-0	2000	Long-chain acyl-CoA dehydrogenase is a key enzyme in the mitochondrial beta-oxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	89-112	acyl-CoA dehydrogenase, long chain	Rattus norvegicus	0-33
22061079-4	2000	The forage-fed lambs all had high concentrations of n-3 polyunsaturated fatty acids (PUFA) including 18:3 (alpha-linolenic acid) and 20:5 (eicosapentaenoic acid) compared with Suffolks-concentrates which had high concentrations of the n-6 PUFA 18:2 (linoleic acid) and 20:4 (arachidonic acid).	Fatty Acids, Unsaturated	85-89	PUFA	Ovis aries	56-83
10827210-0	2000	Regulation of hepatic delta-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice.	Fatty Acids, Unsaturated	72-98	fatty acid desaturase 2	Mus musculus	22-40
10827210-0	2000	Regulation of hepatic delta-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice.	Fatty Acids, Unsaturated	72-98	fatty acid synthase	Mus musculus	113-132
10832093-3	2000	VLCAD, however, was active with CoA derivatives of long-chain saturated fatty acids or unsaturated fatty acids that have double bonds further removed from the thioester function.	Fatty Acids, Unsaturated	87-110	acyl-CoA dehydrogenase, very long chain	Rattus norvegicus	0-5
10832093-6	2000	The conclusion of this study is that LCAD serves an important, if not essential function in the beta-oxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	114-137	acyl-CoA dehydrogenase, long chain	Rattus norvegicus	37-41
10823942-6	2000	The sphingomyelinase activity of nSMase2 has a neutral pH optimum, depends on Mg(2+) ions, and is activated by unsaturated fatty acids and phosphatidylserine.	Fatty Acids, Unsaturated	111-134	sphingomyelin phosphodiesterase 3	Homo sapiens	33-40
10801916-3	2000	Insulin receptor mRNA concentrations in the liver and adipose tissue began to decrease 30 min after the refeeding, in contrast to the plasma insulin increase, and continued to decrease until 8 h. The expression of acetyl-CoA carboxylase and fatty acid synthase mRNA began to increase 4-8 h after feeding and reached maximal levels at 16-24 h. Leptin treatment suppressed the expression of lipogenic enzyme mRNA in rats fed the fat-free diet but not in corn oil-fed rats, in which the expression was suppressed by polyunsaturated fatty acids and leptin expression was higher.	Fatty Acids, Unsaturated	513-540	insulin receptor	Rattus norvegicus	0-16
10927178-4	2000	VCAM-1 expression is stimulated by oxidized polyunsaturated fatty acids such as 13-hydroperoxy-octadecadienoic acid (13-HPODE), and this lipid hydroperoxide has been proposed to be a second messenger for induction of VCAM-1 gene expression.	Fatty Acids, Unsaturated	44-71	vascular cell adhesion molecule 1	Homo sapiens	0-6
10787435-0	2000	Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription.	Fatty Acids, Unsaturated	102-128	peroxisome proliferator activated receptor alpha	Rattus norvegicus	71-80
10787435-0	2000	Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription.	Fatty Acids, Unsaturated	102-128	pyruvate kinase L/R	Rattus norvegicus	152-169
10787435-2	2000	Insulin and glucose induce L-PK gene expression, while glucagon and polyunsaturated fatty acids (PUFA) inhibit L-PK gene expression.	Fatty Acids, Unsaturated	68-95	pyruvate kinase L/R	Rattus norvegicus	111-115
10787435-2	2000	Insulin and glucose induce L-PK gene expression, while glucagon and polyunsaturated fatty acids (PUFA) inhibit L-PK gene expression.	Fatty Acids, Unsaturated	97-101	pyruvate kinase L/R	Rattus norvegicus	111-115
10801916-3	2000	Insulin receptor mRNA concentrations in the liver and adipose tissue began to decrease 30 min after the refeeding, in contrast to the plasma insulin increase, and continued to decrease until 8 h. The expression of acetyl-CoA carboxylase and fatty acid synthase mRNA began to increase 4-8 h after feeding and reached maximal levels at 16-24 h. Leptin treatment suppressed the expression of lipogenic enzyme mRNA in rats fed the fat-free diet but not in corn oil-fed rats, in which the expression was suppressed by polyunsaturated fatty acids and leptin expression was higher.	Fatty Acids, Unsaturated	513-540	fatty acid synthase	Rattus norvegicus	241-260
10776058-7	2000	An important aspect is that when skeletal muscle has a high capacity for lipid oxidation more saturated fatty acids are oxidized and more unsaturated fatty acids are built into the phospholipid fraction of the plasma membrane, giving it more fluidity and improved insulin sensitivity.	Fatty Acids, Unsaturated	138-161	insulin	Homo sapiens	264-271
10809236-3	2000	In cultured rat hepatoma and primary hepatocyte cells, fatty acids and the sulfur-substituted fatty acid analog, tetradecylthioacetic acid, robustly induce LXR alpha (up to 3.5- and 7-fold, respectively) but not LXR beta (also called OR-1) mRNA steady state levels, with unsaturated fatty acids being more effective than saturated fatty acids.	Fatty Acids, Unsaturated	271-294	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	156-165
10775263-5	2000	Our data suggest that the opening of background K(+) channels, like TREK-1 and TRAAK, which are activated by arachidonic acid and other polyunsaturated fatty acids such as docosahexaenoic acid and linolenic acid, is a significant factor in this neuroprotective effect.	Fatty Acids, Unsaturated	136-163	potassium two pore domain channel subfamily K member 2	Homo sapiens	68-74
10775263-5	2000	Our data suggest that the opening of background K(+) channels, like TREK-1 and TRAAK, which are activated by arachidonic acid and other polyunsaturated fatty acids such as docosahexaenoic acid and linolenic acid, is a significant factor in this neuroprotective effect.	Fatty Acids, Unsaturated	136-163	potassium two pore domain channel subfamily K member 4	Homo sapiens	79-84
10767409-0	2000	Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel.	Fatty Acids, Unsaturated	41-68	potassium two pore domain channel subfamily K member 4	Homo sapiens	32-37
10818460-0	2000	A novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid with unsaturated fatty-acid moiety.	Fatty Acids, Unsaturated	79-101	lysophosphatidic acid receptor 3	Homo sapiens	42-46
10767564-1	2000	The purpose of this study was to evaluate the effectiveness and the toxicity of polyunsaturated fatty acid, such as oleic acid, eicosapentaenoic acid (DHA), as potential absorption enhancer for rectal delivery of insulin, using a water-in-oil-in water (W/O/W) multiple emulsion.	Fatty Acids, Unsaturated	80-106	insulin	Homo sapiens	213-220
10729389-3	2000	We investigated the contribution of polymorphisms in the genes for apolipoprotein (apo) B, apo AIV, lipoprotein lipase (LPL) and cholesterol ester transfer protein (CETP) to variation in the changes in plasma concentrations of dense LDL between a high saturated and a high polyunsaturated fatty acid diet.	Fatty Acids, Unsaturated	273-299	cholesteryl ester transfer protein	Homo sapiens	165-169
10729389-8	2000	The greater decrease in dense LDL cholesterol with an increase in polyunsaturated fat seen in those with the apo AIV H360 variant, who represent roughly 10% of the general population, suggests that they may benefit most from a PUFA rich lipid lowering diet.	Fatty Acids, Unsaturated	227-231	apolipoprotein A4	Homo sapiens	109-116
10889793-0	2000	Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance.	Fatty Acids, Unsaturated	0-26	insulin	Homo sapiens	103-110
10802222-4	2000	We also found that traces of hydroperoxides and a high concentration of the target unsaturated fatty acid (LA) needs to be present in a fatty acid mixture before the quasi-lipoxygenase activity of Cyt c becomes apparent.	Fatty Acids, Unsaturated	83-105	cytochrome c, somatic	Homo sapiens	197-202
10889809-1	2000	Insulin sensitivity is potentially enhanced by a range of diet-related changes including reduction of visceral adiposity, a reduction in saturated fatty acids, and possibly a redistribution of the proportions of various unsaturated fatty acids.	Fatty Acids, Unsaturated	220-243	insulin	Homo sapiens	0-7
10889793-4	2000	PUFA exert their effects on lipid metabolism and thermogenesis by upregulating the transcription of the mitochondrial uncoupling protein-3, and inducing genes encoding proteins involved in fatty acid oxidation (e.g. carnitine palmitoyltransferase and acyl-CoA oxidase) while simultaneously down-regulating the transcription of genes encoding proteins involved in lipid synthesis (e.g. fatty acid synthase).	Fatty Acids, Unsaturated	0-4	uncoupling protein 3	Homo sapiens	104-138
10828169-9	2000	Two types of polyunsaturated fatty acid responsive transcription factors have been characterized, the peroxisome proliferator-activated receptor (PPAR) and the hepatic nuclear factor 4alpha.	Fatty Acids, Unsaturated	13-39	peroxisome proliferator activated receptor alpha	Homo sapiens	102-144
10754277-2	2000	Because the majority of 8-epi-PGF(2alpha) in plasma is associated with lipoproteins, it is possible that 8-epi-PGF(2alpha) derived from polyunsaturated fatty acid-rich food may become incorporated within these lipoproteins during synthesis and could contribute to the levels detected in plasma.	Fatty Acids, Unsaturated	136-162	placental growth factor	Homo sapiens	30-33
10754277-2	2000	Because the majority of 8-epi-PGF(2alpha) in plasma is associated with lipoproteins, it is possible that 8-epi-PGF(2alpha) derived from polyunsaturated fatty acid-rich food may become incorporated within these lipoproteins during synthesis and could contribute to the levels detected in plasma.	Fatty Acids, Unsaturated	136-162	placental growth factor	Homo sapiens	111-114
10706594-2	2000	This study examined the effects of dietary alpha-linolenic acid deficiency followed or not by supplementation with phospholipids rich in n;-3 polyunsaturated fatty acid (PUFA) on the fatty acid composition of total phospholipids in 11 brain regions.	Fatty Acids, Unsaturated	142-168	Polyunsaturated fatty acid percentage	Sus scrofa	170-174
10750688-1	2000	This review describes the mechanisms by which polyunsaturated fatty acids regulate the activity of the nuclear transcription factors, peroxisome proliferator-activated receptor and sterol regulatory element binding protein-1, and it describes the role that the peroxisome proliferator-activated receptor and sterol regulatory element binding protein-1 play in coordinating the regulation of lipid synthesis, lipid oxidation, and thermogenesis.	Fatty Acids, Unsaturated	46-73	sterol regulatory element binding transcription factor 1	Homo sapiens	181-224
10750688-1	2000	This review describes the mechanisms by which polyunsaturated fatty acids regulate the activity of the nuclear transcription factors, peroxisome proliferator-activated receptor and sterol regulatory element binding protein-1, and it describes the role that the peroxisome proliferator-activated receptor and sterol regulatory element binding protein-1 play in coordinating the regulation of lipid synthesis, lipid oxidation, and thermogenesis.	Fatty Acids, Unsaturated	46-73	sterol regulatory element binding transcription factor 1	Homo sapiens	308-351
10651928-6	2000	Lipopolysaccharide-stimulated TNF-alpha production by macrophages decreased with increasing unsaturated fatty acid content of the diet (i.e. FO &lt; SO &lt; OO &lt; CO &lt; LF).	Fatty Acids, Unsaturated	92-114	tumor necrosis factor	Mus musculus	30-39
10639339-2	2000	The protein, named Dci1p, shares 50% identity with Eci1p, a delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase that acts as an auxiliary enzyme in the beta-oxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	166-189	putative dodecenoyl-CoA isomerase DCI1	Saccharomyces cerevisiae S288C	19-24
10639339-2	2000	The protein, named Dci1p, shares 50% identity with Eci1p, a delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase that acts as an auxiliary enzyme in the beta-oxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	166-189	dodecenoyl-CoA isomerase	Saccharomyces cerevisiae S288C	51-56
10811021-14	2000	However, HK 42, a polyunsaturated fatty acid analog, was able to reduce dose dependently the release of acinar proteins caused by pancreatic PLA2 and lecithin.	Fatty Acids, Unsaturated	18-44	phospholipase A2 group IB	Rattus norvegicus	141-145
10828169-9	2000	Two types of polyunsaturated fatty acid responsive transcription factors have been characterized, the peroxisome proliferator-activated receptor (PPAR) and the hepatic nuclear factor 4alpha.	Fatty Acids, Unsaturated	13-39	peroxisome proliferator activated receptor alpha	Homo sapiens	146-150
10828169-9	2000	Two types of polyunsaturated fatty acid responsive transcription factors have been characterized, the peroxisome proliferator-activated receptor (PPAR) and the hepatic nuclear factor 4alpha.	Fatty Acids, Unsaturated	13-39	hepatocyte nuclear factor 4 alpha	Homo sapiens	160-189
10617614-8	2000	Here we show that the PUFAs arachidonic acid and eicosapentaenoic acid inhibit Fyn palmitoylation and consequently block Fyn localization to DRMs.	Fatty Acids, Unsaturated	22-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
10620695-3	2000	The absence of ergosterol, an increased accumulation of Delta(8) sterols, a decreased fatty acid chainlength and a lower proportion of unsaturated fatty acids of the erg(-)2 mutant resulted in a higher membrane rigidity and an increased sensitivity to Cr(III) than those of the parental 33 erg(+) strain.	Fatty Acids, Unsaturated	135-158	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	166-173
10617614-8	2000	Here we show that the PUFAs arachidonic acid and eicosapentaenoic acid inhibit Fyn palmitoylation and consequently block Fyn localization to DRMs.	Fatty Acids, Unsaturated	22-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-124
11996112-3	2000	In this paper the reactions of lipids (preferentially unsaturated fatty acids and cholesterol) with either reagent HOCl or HOCl generated by the MPO-hydrogen peroxide-chloride system are reviewed.	Fatty Acids, Unsaturated	54-77	myeloperoxidase	Homo sapiens	145-148
10763110-1	2000	Epaden, the new domestic concentrate of n-3 polyunsaturated fatty acids (PUFA), is capable of inhibiting in vitro the human thrombocyte aggregation induced by ADP, collagen, and thrombin.	Fatty Acids, Unsaturated	73-77	coagulation factor II, thrombin	Homo sapiens	178-186
27416369-8	2000	These results suggest that dietary lipids affect the percentages of arachidonic and docosahexaenoic acids which are released by the endogenous lipase in brain although the decreases in brain polyunsaturated fatty acid content with aging are not due to the enzyme activation, and dietary lipids do not influence the enzyme activity.	Fatty Acids, Unsaturated	191-217	lipase, endothelial	Mus musculus	143-149
10718635-1	2000	Ethanol and polyunsaturated fatty acids such as arachidonic acid were shown to be toxic and cause apoptosis in HepG2 cells which express CYP2E1 but not in control HepG2 cell lines.	Fatty Acids, Unsaturated	12-39	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	137-143
10718635-11	2000	These results extend previous observations found with HepG2 cells expressing CYP2E1 to intact hepatocytes and suggest that release of cytochrome c and activation of caspase 3 play a role in the overall pathway by which CYP2E1 contributes towards the hepatotoxic actions of ethanol and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	285-312	cytochrome c, somatic	Homo sapiens	134-146
10718635-11	2000	These results extend previous observations found with HepG2 cells expressing CYP2E1 to intact hepatocytes and suggest that release of cytochrome c and activation of caspase 3 play a role in the overall pathway by which CYP2E1 contributes towards the hepatotoxic actions of ethanol and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	285-312	caspase 3	Homo sapiens	165-174
10718635-11	2000	These results extend previous observations found with HepG2 cells expressing CYP2E1 to intact hepatocytes and suggest that release of cytochrome c and activation of caspase 3 play a role in the overall pathway by which CYP2E1 contributes towards the hepatotoxic actions of ethanol and polyunsaturated fatty acids.	Fatty Acids, Unsaturated	285-312	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	219-225
10765977-5	2000	In the present study, it was noted that the plasma levels of saturated fatty acids: stearic and palmitic were increased where as unsaturated fatty acids such as oleic, linoleic, gamma-linolenic and eicosapentaenoic acids (OA, LA, GLA and EPA respectively) were decreased in alloxan-induced diabetic rats.	Fatty Acids, Unsaturated	129-152	galactosidase, alpha	Rattus norvegicus	230-233
10585880-0	1999	Function of human mitochondrial 2,4-dienoyl-CoA reductase and rat monofunctional Delta3-Delta2-enoyl-CoA isomerase in beta-oxidation of unsaturated fatty acids.	Fatty Acids, Unsaturated	136-159	enoyl-CoA delta isomerase 1	Rattus norvegicus	87-114
27416369-1	2000	The influences of a fish oil diet and aging on the fatty acid composition in mouse brain, and the release of polyunsaturated fatty acids from brain membranes by endogenous lipase were studied.	Fatty Acids, Unsaturated	109-136	lipase, endothelial	Mus musculus	172-178
10711734-4	2000	It is not known whether polyunsaturated fatty acids regulate expression of candidate genes such as phospholipase A2 and prostaglandin H synthase via activation of nuclear transcription factors such as peroxisome proliferator-activated receptors.	Fatty Acids, Unsaturated	24-51	phospholipase A2 group IB	Homo sapiens	99-115
10551830-0	1999	Sterol response element-binding protein 1c (SREBP1c) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription.	Fatty Acids, Unsaturated	72-98	sterol regulatory element binding transcription factor 1	Homo sapiens	44-51
10585468-0	1999	A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.	Fatty Acids, Unsaturated	112-139	sterol regulatory element binding transcription factor 1	Mus musculus	18-61
10581155-2	1999	Stearoyl-CoA desaturase (SCD) is a key rate-limiting enzyme in the synthesis of unsaturated fatty acids by insertion of a cis-double bond in the Delta9 position of fatty acid substrates.	Fatty Acids, Unsaturated	80-103	stearoyl-Coenzyme A desaturase 1	Mus musculus	25-28
10551830-0	1999	Sterol response element-binding protein 1c (SREBP1c) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription.	Fatty Acids, Unsaturated	72-98	sterol regulatory element binding transcription factor 1	Homo sapiens	0-42
10551830-0	1999	Sterol response element-binding protein 1c (SREBP1c) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription.	Fatty Acids, Unsaturated	72-98	thyroid hormone responsive	Homo sapiens	122-125
10551830-1	1999	Polyunsaturated fatty acids (PUFA) suppress hepatic lipogenic gene transcription through a peroxisome proliferator activated receptor alpha (PPARalpha)- and cyclooxygenase-independent mechanism.	Fatty Acids, Unsaturated	0-27	peroxisome proliferator activated receptor alpha	Homo sapiens	141-150
10551830-1	1999	Polyunsaturated fatty acids (PUFA) suppress hepatic lipogenic gene transcription through a peroxisome proliferator activated receptor alpha (PPARalpha)- and cyclooxygenase-independent mechanism.	Fatty Acids, Unsaturated	29-33	peroxisome proliferator activated receptor alpha	Homo sapiens	141-150
10559135-3	1999	In the ECV-304 endothelial cell line, unsaturated fatty acids triggered a time- and dose-dependent tyrosine phosphorylation of EGFR (polyunsaturated fatty acids [PUFAs] were the most active), whereas saturated FAs were inactive.	Fatty Acids, Unsaturated	38-61	epidermal growth factor receptor	Homo sapiens	127-131
10559135-3	1999	In the ECV-304 endothelial cell line, unsaturated fatty acids triggered a time- and dose-dependent tyrosine phosphorylation of EGFR (polyunsaturated fatty acids [PUFAs] were the most active), whereas saturated FAs were inactive.	Fatty Acids, Unsaturated	133-160	epidermal growth factor receptor	Homo sapiens	127-131
10559135-3	1999	In the ECV-304 endothelial cell line, unsaturated fatty acids triggered a time- and dose-dependent tyrosine phosphorylation of EGFR (polyunsaturated fatty acids [PUFAs] were the most active), whereas saturated FAs were inactive.	Fatty Acids, Unsaturated	162-167	epidermal growth factor receptor	Homo sapiens	127-131
10559135-9	1999	These data suggest that EGFR is activated by OA and PUFAs, acts as a sensor for unsaturated fatty acids (and amphiphilic molecules), and is a potential transducer by which diet composition may influence vascular wall biology.	Fatty Acids, Unsaturated	80-103	epidermal growth factor receptor	Homo sapiens	24-28
10548500-0	1999	Cellular enrichment with polyunsaturated fatty acids induces an oxidative stress and activates the transcription factors AP1 and NFkappaB.	Fatty Acids, Unsaturated	25-52	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-124
10548500-0	1999	Cellular enrichment with polyunsaturated fatty acids induces an oxidative stress and activates the transcription factors AP1 and NFkappaB.	Fatty Acids, Unsaturated	25-52	nuclear factor kappa B subunit 1	Homo sapiens	129-137
10548500-3	1999	Simultaneously, cell enrichment with all the studied PUFA induced an increase in AP1 and NFkappaB binding activity measured by electrophoretic mobility shift assay, whereas no significant effect was observed with the monounsaturated oleic acid.	Fatty Acids, Unsaturated	53-57	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-84
10548500-3	1999	Simultaneously, cell enrichment with all the studied PUFA induced an increase in AP1 and NFkappaB binding activity measured by electrophoretic mobility shift assay, whereas no significant effect was observed with the monounsaturated oleic acid.	Fatty Acids, Unsaturated	53-57	nuclear factor kappa B subunit 1	Homo sapiens	89-97
10464321-6	1999	Although the observed substrate preference was to Delta(2)-trans,Delta(4)-trans-decadienoyl-CoA, PDCR was also active on a C(22) substrate with multiple unsaturations, a result consistent with the role of peroxisomes in the oxidation of complex, very long chain, polyunsaturated fatty acids.	Fatty Acids, Unsaturated	263-290	2,4-dienoyl-CoA reductase 2	Homo sapiens	97-101
10564364-6	1999	We propose that both L1 and bFGF act via the FGFR to generate polyunsaturated fatty acids which in turn cause calcium channels to flicker open and shut.	Fatty Acids, Unsaturated	62-89	fibroblast growth factor 2	Rattus norvegicus	28-32
10488122-6	1999	LPAs with an unsaturated fatty acid but not with a saturated fatty acid induced an increase in the [Ca(2+)](i) of EDG7-expressing Sf9 cells, whereas LPAs with both saturated and unsaturated fatty acids elicited a Ca(2+) response in Sf9 cells expressing EDG4.	Fatty Acids, Unsaturated	13-35	lysophosphatidic acid receptor 3	Rattus norvegicus	114-118
10535395-6	1999	Dietary sesamin also increased the activity of 2,4-dienoyl-CoA reductase and delta3,delta2-enoyl-CoA isomerase, enzymes involved in the auxiliary pathway for beta-oxidation of unsaturated fatty acids dose-dependently.	Fatty Acids, Unsaturated	176-199	enoyl-CoA delta isomerase 1	Rattus norvegicus	77-110
10487921-2	1999	ATF1 transcription is negatively regulated by unsaturated fatty acids and oxygen.	Fatty Acids, Unsaturated	46-69	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	0-4
10487921-4	1999	Ligation of the 18 bp element into a plasmid carrying the CYC1 promoter deleted UAS-activated transcription and conferred transcriptional repression by unsaturated fatty acids.	Fatty Acids, Unsaturated	152-175	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	58-62
10438539-0	1999	Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids.	Fatty Acids, Unsaturated	80-107	sterol regulatory element binding transcription factor 1	Homo sapiens	0-43
10484602-0	1999	Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol.	Fatty Acids, Unsaturated	41-68	stearoyl-Coenzyme A desaturase 1	Mus musculus	14-37
10484602-8	1999	The expression of the mouse SCD genes is regulated by polyunsaturated fatty acids and cholesterol at the levels of transcription and mRNA stability.	Fatty Acids, Unsaturated	54-81	stearoyl-Coenzyme A desaturase 1	Mus musculus	28-31
10484602-9	1999	Promoter elements that are responsible for the polyunsaturated fatty acid repression colocalize with the promoter elements for SREBP-mediated regulation of the SCD genes.	Fatty Acids, Unsaturated	47-73	stearoyl-Coenzyme A desaturase 1	Mus musculus	160-163
10484602-10	1999	It is the goal of this review to provide an overview of the genetic regulation of the stearoyl-CoA desaturase in response to dietary polyunsaturated fatty acids and cholesterol.	Fatty Acids, Unsaturated	133-160	stearoyl-Coenzyme A desaturase 1	Mus musculus	86-109
10574656-1	1999	The present study was designed to investigate the effect of dietary n-6 and n-3 polyunsaturated fatty acids (PUFA) on anti-CD3 and anti-Fas antibody-induced apoptosis and its mediators in mouse spleen cells.	Fatty Acids, Unsaturated	109-113	CD3 antigen, epsilon polypeptide	Mus musculus	123-126
10574656-4	1999	Further, serum vitamin E levels were decreased by 50% in the n-3 PUFA-fed group, whereas higher anti-Fas- and anti-CD3-induced apoptosis (65 and 66%) and necrosis (17 and 25%), compared to the n-6 PUFA-fed group, were found when measured with Annexin V and propidium iodide staining, respectively.	Fatty Acids, Unsaturated	65-69	annexin A5	Mus musculus	243-252
10574656-4	1999	Further, serum vitamin E levels were decreased by 50% in the n-3 PUFA-fed group, whereas higher anti-Fas- and anti-CD3-induced apoptosis (65 and 66%) and necrosis (17 and 25%), compared to the n-6 PUFA-fed group, were found when measured with Annexin V and propidium iodide staining, respectively.	Fatty Acids, Unsaturated	197-201	CD3 antigen, epsilon polypeptide	Mus musculus	115-118
10438539-2	1999	Polyunsaturated fatty acids (PUFA) coordinately suppress the transcription of a wide array of hepatic lipogenic genes including fatty acid synthase (FAS) and acetyl-CoA carboxylase.	Fatty Acids, Unsaturated	0-27	fatty acid synthase	Homo sapiens	128-147
10438539-2	1999	Polyunsaturated fatty acids (PUFA) coordinately suppress the transcription of a wide array of hepatic lipogenic genes including fatty acid synthase (FAS) and acetyl-CoA carboxylase.	Fatty Acids, Unsaturated	0-27	fatty acid synthase	Homo sapiens	149-152
10438539-2	1999	Polyunsaturated fatty acids (PUFA) coordinately suppress the transcription of a wide array of hepatic lipogenic genes including fatty acid synthase (FAS) and acetyl-CoA carboxylase.	Fatty Acids, Unsaturated	29-33	fatty acid synthase	Homo sapiens	128-147
10438539-2	1999	Polyunsaturated fatty acids (PUFA) coordinately suppress the transcription of a wide array of hepatic lipogenic genes including fatty acid synthase (FAS) and acetyl-CoA carboxylase.	Fatty Acids, Unsaturated	29-33	fatty acid synthase	Homo sapiens	149-152
10400691-13	1999	Additional studies demonstrate that maximal transcriptional repression of SCD2 reporter genes in response to an exogenous polyunsaturated fatty acid is dependent upon the SRE and the adjacent CCAAT motif.	Fatty Acids, Unsaturated	122-148	stearoyl-Coenzyme A desaturase 2	Mus musculus	74-78
10423541-1	1999	Transcriptional regulation of ATP citrate-lyase (ACL, one of the lipogenic enzymes) gene by glucose/insulin, polyunsaturated fatty acid (PUFA), and leptin has been investigated in hepatocytes and adipocytes of obese Wistar fatty rats and their lean littermates.	Fatty Acids, Unsaturated	109-135	ATP citrate lyase	Rattus norvegicus	30-47
10423541-1	1999	Transcriptional regulation of ATP citrate-lyase (ACL, one of the lipogenic enzymes) gene by glucose/insulin, polyunsaturated fatty acid (PUFA), and leptin has been investigated in hepatocytes and adipocytes of obese Wistar fatty rats and their lean littermates.	Fatty Acids, Unsaturated	109-135	ATP citrate lyase	Rattus norvegicus	49-52
10423541-1	1999	Transcriptional regulation of ATP citrate-lyase (ACL, one of the lipogenic enzymes) gene by glucose/insulin, polyunsaturated fatty acid (PUFA), and leptin has been investigated in hepatocytes and adipocytes of obese Wistar fatty rats and their lean littermates.	Fatty Acids, Unsaturated	137-141	ATP citrate lyase	Rattus norvegicus	30-47
10423541-1	1999	Transcriptional regulation of ATP citrate-lyase (ACL, one of the lipogenic enzymes) gene by glucose/insulin, polyunsaturated fatty acid (PUFA), and leptin has been investigated in hepatocytes and adipocytes of obese Wistar fatty rats and their lean littermates.	Fatty Acids, Unsaturated	137-141	ATP citrate lyase	Rattus norvegicus	49-52
10413092-0	1999	Selective activation of phospholipase D2 by unsaturated fatty acid.	Fatty Acids, Unsaturated	44-66	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	24-39
10393095-0	1999	Polyunsaturated fatty acids inhibit fatty acid synthase and spot-14-protein gene expression in cultured rat hepatocytes by a peroxidative mechanism.	Fatty Acids, Unsaturated	0-27	fatty acid synthase	Rattus norvegicus	36-55
10393095-0	1999	Polyunsaturated fatty acids inhibit fatty acid synthase and spot-14-protein gene expression in cultured rat hepatocytes by a peroxidative mechanism.	Fatty Acids, Unsaturated	0-27	thyroid hormone responsive	Rattus norvegicus	60-75
10393095-1	1999	In vivo, polyunsaturated fatty acids (PUFA) inhibit the expression of hepatic genes related to the lipogenic process such as fatty acid synthase and spot-14-protein (S14) genes.	Fatty Acids, Unsaturated	9-36	fatty acid synthase	Rattus norvegicus	125-144
10393095-1	1999	In vivo, polyunsaturated fatty acids (PUFA) inhibit the expression of hepatic genes related to the lipogenic process such as fatty acid synthase and spot-14-protein (S14) genes.	Fatty Acids, Unsaturated	9-36	thyroid hormone responsive	Rattus norvegicus	149-164
10393095-1	1999	In vivo, polyunsaturated fatty acids (PUFA) inhibit the expression of hepatic genes related to the lipogenic process such as fatty acid synthase and spot-14-protein (S14) genes.	Fatty Acids, Unsaturated	9-36	thyroid hormone responsive	Rattus norvegicus	166-169
10393095-1	1999	In vivo, polyunsaturated fatty acids (PUFA) inhibit the expression of hepatic genes related to the lipogenic process such as fatty acid synthase and spot-14-protein (S14) genes.	Fatty Acids, Unsaturated	38-42	fatty acid synthase	Rattus norvegicus	125-144
10393095-1	1999	In vivo, polyunsaturated fatty acids (PUFA) inhibit the expression of hepatic genes related to the lipogenic process such as fatty acid synthase and spot-14-protein (S14) genes.	Fatty Acids, Unsaturated	38-42	thyroid hormone responsive	Rattus norvegicus	149-164
10393095-1	1999	In vivo, polyunsaturated fatty acids (PUFA) inhibit the expression of hepatic genes related to the lipogenic process such as fatty acid synthase and spot-14-protein (S14) genes.	Fatty Acids, Unsaturated	38-42	thyroid hormone responsive	Rattus norvegicus	166-169
10393095-6	1999	PUFA inhibited the expression of fatty acid synthase and S14 genes, and this inhibition was directly related to the number of unsaturations.	Fatty Acids, Unsaturated	0-4	fatty acid synthase	Rattus norvegicus	33-52
10393095-6	1999	PUFA inhibited the expression of fatty acid synthase and S14 genes, and this inhibition was directly related to the number of unsaturations.	Fatty Acids, Unsaturated	0-4	thyroid hormone responsive	Rattus norvegicus	57-60
10393095-7	1999	However, the beta-actin and albumin mRNA concentrations were also affected by the most unsaturated fatty acids, suggesting a non-specific effect of PUFA on gene expression.	Fatty Acids, Unsaturated	87-110	actin, beta	Rattus norvegicus	13-23
10333503-4	1999	A primary structure analysis of these novel proteins revealed that one, ending in the tripeptide AKL, is homologous to the yeast peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34; DCR), an enzyme required for the degradation of unsaturated fatty acids, and that the other, ending in the tripeptide SRL, is a putative member of the short-chain dehydrogenase/reductase (SDR) family, with three isoforms.	Fatty Acids, Unsaturated	229-252	short-chain dehydrogenase/reductase	Saccharomyces cerevisiae S288C	332-367
10384723-3	1999	Source CAD-MS2 experiments permit assignment of double bond locations in polyunsaturated fatty acid substituents.	Fatty Acids, Unsaturated	73-99	MS2	Homo sapiens	11-14
10386609-3	1999	Fatty acid analysis of native and HOCl-modified HDL3 revealed that unsaturated fatty acids in both major lipid subclasses (phospholipids and cholesteryl esters) are targets for HOCl attack.	Fatty Acids, Unsaturated	67-90	high density lipoprotein (HDL) level 3	Mus musculus	48-52
10404015-4	1999	Serum IGFBP was influenced by dietary polyunsaturated fatty acid (PUFA) type ((n-6) and (n-3)) and CLA (p = 0.01 for 38-43 kDa bands corresponding to IGFBP-3).	Fatty Acids, Unsaturated	38-64	insulin-like growth factor binding protein 3	Rattus norvegicus	6-11
10403380-0	1999	Polyunsaturated fatty acids potentiate interleukin-1-stimulated arachidonic acid release by cells overexpressing type IIA secretory phospholipase A2.	Fatty Acids, Unsaturated	0-27	interleukin 1 alpha	Homo sapiens	39-52
10403380-0	1999	Polyunsaturated fatty acids potentiate interleukin-1-stimulated arachidonic acid release by cells overexpressing type IIA secretory phospholipase A2.	Fatty Acids, Unsaturated	0-27	phospholipase A2 group IB	Homo sapiens	132-148
10403380-1	1999	By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells.	Fatty Acids, Unsaturated	142-169	phospholipase A2 group IB	Homo sapiens	98-114
10403380-1	1999	By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells.	Fatty Acids, Unsaturated	142-169	phospholipase A2 group IB	Homo sapiens	116-120
10403380-1	1999	By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells.	Fatty Acids, Unsaturated	142-169	phospholipase A2 group IB	Homo sapiens	221-225
10403380-1	1999	By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells.	Fatty Acids, Unsaturated	142-169	interleukin 1 alpha	Homo sapiens	282-301
10403380-1	1999	By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells.	Fatty Acids, Unsaturated	171-176	phospholipase A2 group IB	Homo sapiens	98-114
10403380-1	1999	By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells.	Fatty Acids, Unsaturated	171-176	phospholipase A2 group IB	Homo sapiens	116-120
10403380-1	1999	By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells.	Fatty Acids, Unsaturated	171-176	phospholipase A2 group IB	Homo sapiens	221-225
10403380-1	1999	By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells.	Fatty Acids, Unsaturated	171-176	interleukin 1 alpha	Homo sapiens	282-301
10333503-4	1999	A primary structure analysis of these novel proteins revealed that one, ending in the tripeptide AKL, is homologous to the yeast peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34; DCR), an enzyme required for the degradation of unsaturated fatty acids, and that the other, ending in the tripeptide SRL, is a putative member of the short-chain dehydrogenase/reductase (SDR) family, with three isoforms.	Fatty Acids, Unsaturated	229-252	short-chain dehydrogenase/reductase	Saccharomyces cerevisiae S288C	369-372
10229681-1	1999	A critical step in the synthesis of unsaturated fatty acids is catalysed by stearoyl-CoA desaturase (Scd).	Fatty Acids, Unsaturated	36-59	stearoyl-CoA desaturase	Homo sapiens	76-99
10375220-16	1999	Synovex increased the monounsaturated fatty acids (MUFA), and the combinaton of Syn with rbST reduced polyunsaturated fatty acid (PUFA) concentration in the longissimus muscle (at the 12th rib).	Fatty Acids, Unsaturated	102-128	PUFA	Bos taurus	130-134
10229681-1	1999	A critical step in the synthesis of unsaturated fatty acids is catalysed by stearoyl-CoA desaturase (Scd).	Fatty Acids, Unsaturated	36-59	stearoyl-CoA desaturase	Homo sapiens	101-104
10470146-1	1999	Synthetic propane diol lipids have been proposed as novel compounds to deliver cytocidal polyunsaturated fatty acids (PUFA) such as gamma-linolenic (GLA) and eicosapentaenoic (EPA) acids.	Fatty Acids, Unsaturated	89-116	galactosidase, alpha	Mus musculus	149-152
10470146-1	1999	Synthetic propane diol lipids have been proposed as novel compounds to deliver cytocidal polyunsaturated fatty acids (PUFA) such as gamma-linolenic (GLA) and eicosapentaenoic (EPA) acids.	Fatty Acids, Unsaturated	118-122	galactosidase, alpha	Mus musculus	149-152
10231366-1	1999	We previously showed that unsaturated fatty acids induced gene expression of cellular retinol-binding protein type II (CRBPII) in rat jejunum [Suruga, K., Suzuki, R., Goda, T. and Takase, S. (1995) J. Nutr.	Fatty Acids, Unsaturated	26-49	retinol binding protein 2	Rattus norvegicus	77-117
10231366-1	1999	We previously showed that unsaturated fatty acids induced gene expression of cellular retinol-binding protein type II (CRBPII) in rat jejunum [Suruga, K., Suzuki, R., Goda, T. and Takase, S. (1995) J. Nutr.	Fatty Acids, Unsaturated	26-49	retinol binding protein 2	Rattus norvegicus	119-125
10380119-6	1999	Diet LCP1 was structured to closely replicate the principal long chain polyunsaturated fatty acids (PUFA) found in human breast milk and contained 0.9% AA and 0.6% DHA (% of total fatty acids) whereas diet LCP3 contained 2.7% AA and 1.8% DHA.	Fatty Acids, Unsaturated	100-104	lymphocyte cytosolic protein 1	Homo sapiens	5-9
10340708-3	1999	In cells from mice kept on a diet rich in unsaturated fatty acid, there was a marked expression of Hsp 25 and Hsp 27 after only 30 days of treatment, which was maintained constant for up to 4 months; while for bands corresponding to Hsp 60 and Hsp 70, a significant minor signal was only detectable after 2-4 months from the beginning of the treatment.	Fatty Acids, Unsaturated	42-64	heat shock protein 1	Mus musculus	99-105
10340708-3	1999	In cells from mice kept on a diet rich in unsaturated fatty acid, there was a marked expression of Hsp 25 and Hsp 27 after only 30 days of treatment, which was maintained constant for up to 4 months; while for bands corresponding to Hsp 60 and Hsp 70, a significant minor signal was only detectable after 2-4 months from the beginning of the treatment.	Fatty Acids, Unsaturated	42-64	heat shock protein 1	Mus musculus	110-116
10340708-3	1999	In cells from mice kept on a diet rich in unsaturated fatty acid, there was a marked expression of Hsp 25 and Hsp 27 after only 30 days of treatment, which was maintained constant for up to 4 months; while for bands corresponding to Hsp 60 and Hsp 70, a significant minor signal was only detectable after 2-4 months from the beginning of the treatment.	Fatty Acids, Unsaturated	42-64	heat shock protein 1 (chaperonin)	Mus musculus	233-239
10340708-3	1999	In cells from mice kept on a diet rich in unsaturated fatty acid, there was a marked expression of Hsp 25 and Hsp 27 after only 30 days of treatment, which was maintained constant for up to 4 months; while for bands corresponding to Hsp 60 and Hsp 70, a significant minor signal was only detectable after 2-4 months from the beginning of the treatment.	Fatty Acids, Unsaturated	42-64	heat shock protein 1B	Mus musculus	244-250
10196018-7	1999	Alcohol consumption, use of antioxidant vitamin supplements, and a high intake of protein, fat, monounsaturated fatty acids, and all/n-3 polyunsaturated fatty acids were somewhat protective against IgAN.	Fatty Acids, Unsaturated	137-164	IGAN1	Homo sapiens	198-202
10391529-1	1999	OBJECTIVE: To assess the relationship between the free intake of long chain w3 polyunsaturated fatty acid (w3 LCP) during pregnancy and the levels in the mother with the levels in the neonate.	Fatty Acids, Unsaturated	79-105	kelch domain containing 2	Homo sapiens	110-113
10358937-8	1999	In addition to these PLD isozymes, there exists another PLD isozyme which is activated by unsaturated fatty acids such as oleic acid, although its molecular nature and physiological roles are not well defined.	Fatty Acids, Unsaturated	90-113	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	21-24
10358937-8	1999	In addition to these PLD isozymes, there exists another PLD isozyme which is activated by unsaturated fatty acids such as oleic acid, although its molecular nature and physiological roles are not well defined.	Fatty Acids, Unsaturated	90-113	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	56-59
10219999-9	1999	Analysis using an ATF2-lacZ fusion gene in S. pastorianus showed that expression of the ATF2 gene was relatively lower than that of the ATF1 gene and that it is repressed by aeration but activated by the addition of unsaturated fatty acids.	Fatty Acids, Unsaturated	216-239	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	18-22
10443969-6	1999	Whereas it is well established that both H-FABP and B-FABP interact with polyunsaturated fatty acids, we showed that they also significantly alter plasma membrane cholesterol dynamics in a manner opposite to that of another brain lipid-binding protein, sterol carrier protein-2.	Fatty Acids, Unsaturated	73-100	fatty acid binding protein 3, muscle and heart	Mus musculus	41-47
10443969-6	1999	Whereas it is well established that both H-FABP and B-FABP interact with polyunsaturated fatty acids, we showed that they also significantly alter plasma membrane cholesterol dynamics in a manner opposite to that of another brain lipid-binding protein, sterol carrier protein-2.	Fatty Acids, Unsaturated	73-100	fatty acid binding protein 7, brain	Mus musculus	52-58
10219999-9	1999	Analysis using an ATF2-lacZ fusion gene in S. pastorianus showed that expression of the ATF2 gene was relatively lower than that of the ATF1 gene and that it is repressed by aeration but activated by the addition of unsaturated fatty acids.	Fatty Acids, Unsaturated	216-239	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	88-92
10095788-0	1999	Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats.	Fatty Acids, Unsaturated	75-101	fatty acid synthase	Rattus norvegicus	30-49
10066369-9	1999	Our results suggest that nFA-p34, might be involved in the shuttling of unsaturated FA between the cytosol and the plasma membrane of neutrophils.	Fatty Acids, Unsaturated	72-86	alpha and gamma adaptin binding protein	Homo sapiens	29-32
10095788-1	1999	Transcriptional regulation of the fatty acid synthase (FAS) gene by insulin/glucose, polyunsaturated fatty acids and leptin was investigated in hepatocytes and adipocytes of Wistar fatty rats and their lean littermates.	Fatty Acids, Unsaturated	85-112	fatty acid synthase	Rattus norvegicus	34-53
10095788-1	1999	Transcriptional regulation of the fatty acid synthase (FAS) gene by insulin/glucose, polyunsaturated fatty acids and leptin was investigated in hepatocytes and adipocytes of Wistar fatty rats and their lean littermates.	Fatty Acids, Unsaturated	85-112	fatty acid synthase	Rattus norvegicus	55-58
10095788-12	1999	Leptin and polyunsaturated fatty acids appeared to suppress the insulin stimulation of FAS transcription by reducing the insulin-binding capacities of receptors.	Fatty Acids, Unsaturated	11-38	fatty acid synthase	Rattus norvegicus	87-90
10194676-6	1999	Milk fat from cows fed wet corn distillers grains contained lower concentrations of saturated fatty acids and higher concentrations of long-chain and unsaturated fatty acids.	Fatty Acids, Unsaturated	150-173	Weaning weight-maternal milk	Bos taurus	0-4
10194676-7	1999	The feeding of wet corn distillers grains increased the proportion of unsaturated fatty acids in milk fat without changing milk production.	Fatty Acids, Unsaturated	70-93	Weaning weight-maternal milk	Bos taurus	97-101
9917340-1	1999	We have previously demonstrated that dietary fat, especially unsaturated fatty acids, induces cellular retinol-binding protein, type II (CRBPII) gene expression in rat jejunum.	Fatty Acids, Unsaturated	61-84	retinol binding protein 2	Rattus norvegicus	94-135
9917340-1	1999	We have previously demonstrated that dietary fat, especially unsaturated fatty acids, induces cellular retinol-binding protein, type II (CRBPII) gene expression in rat jejunum.	Fatty Acids, Unsaturated	61-84	retinol binding protein 2	Rattus norvegicus	137-143
9892230-1	1999	In adult humans, insulin resistance is associated with relatively low proportions of polyunsaturated fatty acids (PUFAs) in muscle membrane structural lipid.	Fatty Acids, Unsaturated	85-112	insulin	Homo sapiens	17-24
10450326-1	1999	The present review focuses on the importance of polyunsaturated fatty acid (PUFA) provision for the normal development of the pig neonate.	Fatty Acids, Unsaturated	76-80	Polyunsaturated fatty acid percentage	Sus scrofa	48-74
9927444-5	1999	The level of unsaturated fatty acids decreases 35-40% when the mga2Delta spt23-ts mutant is incubated at 37 degrees.	Fatty Acids, Unsaturated	13-36	Spt23p	Saccharomyces cerevisiae S288C	73-78
10065739-1	1999	The objective of this study was to investigate the impact of feeding mice a diet rich in n-3 polyunsaturated fatty acids (PUFA) from fish oil on the interleukin-12 (IL-12) and interferon-gamma (IFNgamma) production during the early stage of an infectious challenge with Listeria monocytogenes.	Fatty Acids, Unsaturated	122-126	interferon gamma	Mus musculus	194-202
10064336-4	1999	Unsaturated fatty acids can inhibit GTPase activating protein, thereby quenching signals from p21-ras.	Fatty Acids, Unsaturated	0-23	HRas proto-oncogene, GTPase	Homo sapiens	94-101
10192911-5	1999	These results indicate that the interactive action of sex-related factor(s) with dietary polyunsaturated fatty acids is involved in metabolic changes of serum lipids in apoE-deficient mice, and addition of DHA, compared with addition of SO, is not effective to abolish the atherosclerosis in this animal model.	Fatty Acids, Unsaturated	89-116	apolipoprotein E	Mus musculus	169-173
9930700-0	1999	Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL.	Fatty Acids, Unsaturated	0-27	transient receptor potential-like	Drosophila melanogaster	85-89
9930700-2	1999	Most attention has focused on inositol-1,4,5-trisphosphate, a second messenger produced by PLC from phosphatidylinositol-4,5-bisphosphate; however, PLC also generates diacylglycerol, a potential precursor for several polyunsaturated fatty acids, such as arachidonic acid and linolenic acid.	Fatty Acids, Unsaturated	217-244	Phospholipase C at 21C	Drosophila melanogaster	91-94
9930700-2	1999	Most attention has focused on inositol-1,4,5-trisphosphate, a second messenger produced by PLC from phosphatidylinositol-4,5-bisphosphate; however, PLC also generates diacylglycerol, a potential precursor for several polyunsaturated fatty acids, such as arachidonic acid and linolenic acid.	Fatty Acids, Unsaturated	217-244	Phospholipase C at 21C	Drosophila melanogaster	148-151
9892230-1	1999	In adult humans, insulin resistance is associated with relatively low proportions of polyunsaturated fatty acids (PUFAs) in muscle membrane structural lipid.	Fatty Acids, Unsaturated	114-119	insulin	Homo sapiens	17-24
9892230-9	1999	The less unsaturated muscle membranes in children whose mothers have higher fasting insulin and triglyceride levels may reflect a genetic reluctance to incorporate PUFAs into membranes, thus predisposing them to insulin resistance syndromes.	Fatty Acids, Unsaturated	164-169	insulin	Homo sapiens	84-91
9892230-9	1999	The less unsaturated muscle membranes in children whose mothers have higher fasting insulin and triglyceride levels may reflect a genetic reluctance to incorporate PUFAs into membranes, thus predisposing them to insulin resistance syndromes.	Fatty Acids, Unsaturated	164-169	insulin	Homo sapiens	212-219
10435119-1	1999	Polyunsaturated fatty acids of omega-3 series (omega-3 or n-3 PUFA), especially long chain EPA and DHA, exert strong positive influence on human health.	Fatty Acids, Unsaturated	0-27	pumilio RNA binding family member 3	Homo sapiens	62-66
10048767-2	1999	We hypothesized that the n-3 PUFA-induced hyporesponsiveness to IFN-gamma is mediated, in part, by a reduction in the number of IFN-gamma receptors (IFNGR) expressed on the surface of these cells.	Fatty Acids, Unsaturated	29-33	interferon gamma	Mus musculus	64-73
9890193-9	1999	Our results suggest that certain unsaturated fatty acids can potentiate PCB-mediated endothelial cell dysfunction and that oxidative stress and activation of the cytochrome P450 1A subfamily may be, in part, responsible for these metabolic events.	Fatty Acids, Unsaturated	33-56	pyruvate carboxylase	Homo sapiens	72-75
10048767-2	1999	We hypothesized that the n-3 PUFA-induced hyporesponsiveness to IFN-gamma is mediated, in part, by a reduction in the number of IFN-gamma receptors (IFNGR) expressed on the surface of these cells.	Fatty Acids, Unsaturated	29-33	interferon gamma receptor 1	Mus musculus	149-154
10048767-5	1999	High n-3 PUFA intake was associated with a significant (n = 2, p &lt; 0.01) reduction in [125I]-IFN-gamma binding without affecting binding affinity (Kd).	Fatty Acids, Unsaturated	9-13	interferon gamma	Mus musculus	96-105
10048767-9	1999	High n-3 PUFA diet was associated with a 50% decline (n = 3-6, p &lt; 0.05) in total IFNGR-1 in both immune cell populations studied.	Fatty Acids, Unsaturated	9-13	interferon gamma receptor 1	Mus musculus	85-92
10222498-7	1999	Diets rich in polyunsaturated FA (PUFA) stimulate the production of chylomicrons by the intestine (at peak lipid absorption) and of high density lipoproteins by the liver, leading to high blood concentrations of cholesterol.	Fatty Acids, Unsaturated	14-32	PUFA	Bos taurus	34-38