PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 12087352-0 2002 Effect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C. BACKGROUND: Interferon alpha (IFN-alpha) is thought to be responsible for cytochrome P450 (CYP)-dependent drug interactions mediated by a decrease in CYP activities. alpha-Ribavirin 21-36 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 50-65 22652581-1 2012 BACKGROUND: The purpose of this research was to compare interferon (IFN) responsiveness in treatment-naive and pegylated interferon alpha-ribavirin (P/R)-experienced subjects and to understand the implications of comparability in IFN responsiveness across treatment courses on drug development and clinical decision making. alpha-Ribavirin 132-147 interferon alpha 1 Homo sapiens 56-72 22652581-1 2012 BACKGROUND: The purpose of this research was to compare interferon (IFN) responsiveness in treatment-naive and pegylated interferon alpha-ribavirin (P/R)-experienced subjects and to understand the implications of comparability in IFN responsiveness across treatment courses on drug development and clinical decision making. alpha-Ribavirin 132-147 interferon alpha 1 Homo sapiens 56-66 22652581-1 2012 BACKGROUND: The purpose of this research was to compare interferon (IFN) responsiveness in treatment-naive and pegylated interferon alpha-ribavirin (P/R)-experienced subjects and to understand the implications of comparability in IFN responsiveness across treatment courses on drug development and clinical decision making. alpha-Ribavirin 132-147 interferon alpha 1 Homo sapiens 68-71 23280583-1 2013 Based on investigations of liver biopsy material, certain cellular genes have been implicated as correlates of success or failure to interferon alpha-ribavirin (IFN/RBV) therapy against hepatitis C. The current study aimed at determining whether expression of host genes thought to be relevant to HCV replication in the liver would be correlated with HCV infection status in peripheral blood mononuclear cells (PBMCs) and also with patient responsiveness to IFN/RBV treatment. alpha-Ribavirin 144-159 interferon alpha 1 Homo sapiens 161-164