PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22134920-3	2012	We recently revealed that purified recombinant H-rev107 has phospholipase A(1/2) activity, releasing free fatty acids from glycerophospholipids with a preference for esterolysis at the sn-1 position.	Glycerophospholipids	123-143	phospholipase A and acyltransferase 3	Homo sapiens	47-55
22134920-3	2012	We recently revealed that purified recombinant H-rev107 has phospholipase A(1/2) activity, releasing free fatty acids from glycerophospholipids with a preference for esterolysis at the sn-1 position.	Glycerophospholipids	123-143	lipase H	Homo sapiens	60-79
21868473-4	2011	PLA(2) enzymes hydrolyze membrane glycerophospholipids to yield a free fatty acid and lysophospholipid.	Glycerophospholipids	34-54	phospholipase A2, group IB, pancreas	Mus musculus	0-6
22426716-1	2012	Plant phospholipases can be grouped into four major types, phospholipase D, phospholipase C, phospholipase A1 (PLA(1)), and phospholipase A2 (PLA(2)), that hydrolyze glycerophospholipids at different ester bonds.	Glycerophospholipids	166-186	phospholipase A2 group IB	Homo sapiens	124-140
22426716-1	2012	Plant phospholipases can be grouped into four major types, phospholipase D, phospholipase C, phospholipase A1 (PLA(1)), and phospholipase A2 (PLA(2)), that hydrolyze glycerophospholipids at different ester bonds.	Glycerophospholipids	166-186	phospholipase A2 group IB	Homo sapiens	142-148
22848682-12	2012	The over-representation of 160/18:2- and 16:0/18:3-species in PLD products when compared to putative substrates might be related to a regulatory role of the heterogeneous distribution of glycerophospholipids in membrane sub-domains.	Glycerophospholipids	187-207	phospholipase D alpha 1	Arabidopsis thaliana	62-65
21622863-1	2011	Secretory phospholipase A(2)s (sPLA(2)) hydrolyze glycerophospholipids to liberate lysophospholipids and free fatty acids.	Glycerophospholipids	50-70	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	0-29
21873652-2	2011	AGPAT2 generates precursors for the synthesis of glycerophospholipids and triacylglycerols.	Glycerophospholipids	49-69	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	Mus musculus	0-6
22028670-6	2011	Lipidome-wide analysis of mutants further showed that cantharidin induces alterations in glycerophospholipid and sphingolipid abundance in a Crg1-dependent manner.	Glycerophospholipids	89-108	S-adenosylmethionine-dependent methyltransferase	Saccharomyces cerevisiae S288C	141-145
21803774-3	2011	We overexpressed AT1G78690 in Escherichia coli, extracted the cellular lipids, and identified the accumulating glycerophospholipid as acylphosphatidylglycerol (acyl-PG).	Glycerophospholipids	111-130	Phospholipid/glycerol acyltransferase family protein	Arabidopsis thaliana	17-26
21723818-1	2011	Secretory phospholipase A(2) (sPLA(2)) catalyzes the hydrolysis of glycerophospholipids.	Glycerophospholipids	67-87	phospholipase A2 group X	Homo sapiens	0-28
21723818-1	2011	Secretory phospholipase A(2) (sPLA(2)) catalyzes the hydrolysis of glycerophospholipids.	Glycerophospholipids	67-87	phospholipase A2 group X	Homo sapiens	30-37
21703303-5	2011	Degradation of GPs by phospholipase A(2) can release two important brain polyunsaturated fatty acids (PUFAs), e.g., arachidonic acid and docosahexaenoic acid, linked together by a delicate equilibrium.	Glycerophospholipids	15-18	phospholipase A2 group IB	Homo sapiens	22-39
21746768-1	2011	Phospholipase A(2) (PLA(2)) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids.	Glycerophospholipids	77-97	phospholipase A2, group IB, pancreas	Mus musculus	0-18
21746768-1	2011	Phospholipase A(2) (PLA(2)) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids.	Glycerophospholipids	77-97	phospholipase A2, group IB, pancreas	Mus musculus	20-26
21622863-1	2011	Secretory phospholipase A(2)s (sPLA(2)) hydrolyze glycerophospholipids to liberate lysophospholipids and free fatty acids.	Glycerophospholipids	50-70	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	31-38
21074554-1	2011	A phospholipase A2 was identified from MDCK cell homogenates with broad specificity toward glycerophospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol.	Glycerophospholipids	91-111	phospholipase A2 group IB	Canis lupus familiaris	2-18
21445663-1	2011	Phospholipase A(2) (PLA(2)) is a group of enzymes that hydrolyze the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids.	Glycerophospholipids	86-106	phospholipase A2, group IB, pancreas	Mus musculus	0-18
21445663-1	2011	Phospholipase A(2) (PLA(2)) is a group of enzymes that hydrolyze the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids.	Glycerophospholipids	86-106	phospholipase A2, group IB, pancreas	Mus musculus	20-26
21126862-6	2011	This study revealed a spatial heterogeneity in the human milk fat globule membrane (MFGM), with the lateral segregation of SM in liquid-ordered phase domains of various shapes and sizes surrounded by a liquid-disordered phase composed of the glycerophospholipids in which the proteins are dispersed.	Glycerophospholipids	242-262	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	57-82
21126862-6	2011	This study revealed a spatial heterogeneity in the human milk fat globule membrane (MFGM), with the lateral segregation of SM in liquid-ordered phase domains of various shapes and sizes surrounded by a liquid-disordered phase composed of the glycerophospholipids in which the proteins are dispersed.	Glycerophospholipids	242-262	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	84-88
21173190-11	2011	More importantly, localization of overexpressed AGPAT5 (this study) as well as GPAT1 and 2 (previous studies) in mitochondria supports the idea that the mitochondria might be capable of synthesizing some of their own glycerophospholipids.	Glycerophospholipids	217-237	1-acylglycerol-3-phosphate O-acyltransferase 5	Homo sapiens	48-54
21173190-11	2011	More importantly, localization of overexpressed AGPAT5 (this study) as well as GPAT1 and 2 (previous studies) in mitochondria supports the idea that the mitochondria might be capable of synthesizing some of their own glycerophospholipids.	Glycerophospholipids	217-237	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	79-90
21378031-3	2011	PAF is a potent phosphoglyceride involved in different pathophysiological conditions affecting the cardiovascular system, including the development of myocardial I/R injury.	Glycerophospholipids	16-32	PCNA clamp associated factor	Homo sapiens	0-3
21074554-9	2011	A marked accumulation of glycerophospholipids and extensive lamellar inclusion bodies, a hallmark of cellular phospholipidosis, is observed in alveolar macrophages in LPLA2(-/-) mice.	Glycerophospholipids	25-45	phospholipase A2, group XV	Mus musculus	167-172
20732873-1	2010	The Group VIA phospholipase A(2) (iPLA(2)beta) hydrolyzes glycerophospholipids at the sn-2-position to yield a free fatty acid and a 2-lysophospholipid, and iPLA(2)beta has been reported to participate in apoptosis, phospholipid remodeling, insulin secretion, transcriptional regulation, and other processes.	Glycerophospholipids	58-78	phospholipase A2 group VI	Rattus norvegicus	34-45
20732873-1	2010	The Group VIA phospholipase A(2) (iPLA(2)beta) hydrolyzes glycerophospholipids at the sn-2-position to yield a free fatty acid and a 2-lysophospholipid, and iPLA(2)beta has been reported to participate in apoptosis, phospholipid remodeling, insulin secretion, transcriptional regulation, and other processes.	Glycerophospholipids	58-78	phospholipase A2 group VI	Rattus norvegicus	157-168
20153800-1	2010	Phospholipases A2 (PLA2) are a family of enzymes that catalyze the hydrolysis of the sn-2 ester bond of glycerophospholipids liberating lysophospholipids and free fatty acids; important second messengers involved in atherogenesis.	Glycerophospholipids	104-124	phospholipase A2 group IIA	Homo sapiens	19-23
20801654-3	2010	The ability of three fatty acids (oleic, linoleic, and arachidonic acids) typically contained in the lipid portion of the glycerophospholipids to bind and be oxidized by myeloperoxidase was measured by spectroscopically observing interactions of the lipids with the heme prosthetic group of the enzyme.	Glycerophospholipids	122-142	myeloperoxidase	Homo sapiens	170-185
20152858-3	2010	In mammalian tissues, NAEs are formed from glycerophospholipids through the phosphodiesterase-transacylation pathway consisting of Ca(2+)-dependent N-acyltransferase and N-acylphosphatidylethanolamine-hydrolyzing phospholipase D.	Glycerophospholipids	43-63	N-acyl phosphatidylethanolamine phospholipase D	Homo sapiens	170-228
20227521-2	2010	Eicosanoids are synthesized from intracellular arachidonic acid (AA), which is released from membrane glycerophospholipids mainly by the action of cytosolic phospholipase A(2)alpha (cPLA(2)alpha).	Glycerophospholipids	102-122	phospholipase A2 group IVA	Homo sapiens	182-194
20443212-1	2010	Bee venom phospholipase A(2) (BvPLA(2)) is a lipolytic enzyme that catalyzes the hydrolysis of the sn-2 acyl bond of glycerophospholipids to liberate free fatty acids and lysophospholipids.	Glycerophospholipids	117-137	phospholipase A2	Apis cerana	10-28
20127525-1	2010	Phospholipases A(2) (PLA(2)s) are a diverse family of lipolytic enzymes which hydrolyze the acyl bond at the sn-2 position of glycerophospholipids to produce free fatty acids and lysophospholipids.	Glycerophospholipids	126-146	phospholipase A2 group IIA	Homo sapiens	21-28
20443212-1	2010	Bee venom phospholipase A(2) (BvPLA(2)) is a lipolytic enzyme that catalyzes the hydrolysis of the sn-2 acyl bond of glycerophospholipids to liberate free fatty acids and lysophospholipids.	Glycerophospholipids	117-137	phospholipase A2	Apis mellifera	30-38
20335986-4	2010	A variety of chemical and enzymatic routes have been reported in the literature for the synthesis of LPLs: the enzymatic transformation of natural glycerophospholipids (GPLs) using regiospecific enzymes such as phospholipases A1 (PLA1), A2 (PLA2) phospholipase D (PLD) and different lipases, the coupling of enzymatic processes with chemical transformations, the complete chemical synthesis of LPLs starting from glycerol or derivatives.	Glycerophospholipids	147-167	POU class 2 homeobox 3	Homo sapiens	230-234
20060379-1	2010	In vivo oxidation of glycerophospholipid generates a variety of products including truncated oxidized phospholipids (tOx-PLs).	Glycerophospholipids	21-40	thymocyte selection associated high mobility group box	Homo sapiens	117-120
19230851-1	2009	Group IVA phospholipase A(2) (GIVA PLA(2)) catalyzes the release of arachidonic acid (AA) from the sn-2 position of glycerophospholipids.	Glycerophospholipids	116-136	phospholipase A2 group IB	Homo sapiens	35-41
20016004-3	2010	Interestingly, lipid analysis revealed that deletion of TGL3 resulted in a decrease and overexpression of TGL3 in an increase of glycerophospholipids.	Glycerophospholipids	129-149	bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase	Saccharomyces cerevisiae S288C	56-60
20016004-3	2010	Interestingly, lipid analysis revealed that deletion of TGL3 resulted in a decrease and overexpression of TGL3 in an increase of glycerophospholipids.	Glycerophospholipids	129-149	bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase	Saccharomyces cerevisiae S288C	106-110
19162222-5	2009	AGPAT2 plays a critical role in the synthesis of glycerophospholipids and triglycerides required for lipid droplet formation.	Glycerophospholipids	49-69	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	Mus musculus	0-6
19577642-1	2009	Phospholipases A2 (PLA2) catalyse the cleavage of fatty acids esterified at the sn-2 position of glycerophospholipids.	Glycerophospholipids	97-117	phospholipase A2 group VI	Homo sapiens	19-23
19575637-5	2009	From work with Saccharomyces cerevisiae, much has been learned about glycerophospholipid and ergosterol regulation through Ino2p/Ino4p and Upc2p transcription factors, respectively.	Glycerophospholipids	69-88	Ino2p	Saccharomyces cerevisiae S288C	123-128
18761105-1	2009	Cytosolic phospholipase A(2)-alpha (cPLA(2)-alpha) cleaves its preferred substrate, arachidonic acid, at the sn-2 position of membrane glycerophospholipids.	Glycerophospholipids	135-155	phospholipase A2 group IVA	Homo sapiens	36-49
18840708-1	2009	Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) catalyzes release of arachidonic acid from glycerophospholipids, leading to thromboxane A(2) (TxA(2)) production.	Glycerophospholipids	97-117	phospholipase A2 group IVA	Homo sapiens	0-52
19575637-5	2009	From work with Saccharomyces cerevisiae, much has been learned about glycerophospholipid and ergosterol regulation through Ino2p/Ino4p and Upc2p transcription factors, respectively.	Glycerophospholipids	69-88	Ino4p	Saccharomyces cerevisiae S288C	129-134
18775417-1	2008	Phospholipase A(2) (PLA(2)) are esterases that cleave glycerophospholipids to release fatty acids and lysophospholipids.	Glycerophospholipids	54-74	phospholipase A2 group IB	Homo sapiens	0-18
18983939-1	2009	Glycerol-3-phosphate acyltransferase 1 (GPAT1) is a rate limiting enzyme in de novo glycerophospholipid synthesis.	Glycerophospholipids	84-103	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	0-38
18983939-1	2009	Glycerol-3-phosphate acyltransferase 1 (GPAT1) is a rate limiting enzyme in de novo glycerophospholipid synthesis.	Glycerophospholipids	84-103	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	40-45
19308689-6	2008	PAF is a bioactive lipid produced by a variety of cells from membrane glycerophospholipids in the same reaction that releases arachidonic acid, and can be secreted by platelets, inflammatory cells, keratinocytes and endothelial cells.	Glycerophospholipids	70-90	PCNA clamp associated factor	Homo sapiens	0-3
18937225-6	2008	This approach was demonstrated to be effective on isobaric members of the lysophosphatidylcholine (LPC) and platelet activating factor (PAF) families of glycerophospholipids.	Glycerophospholipids	153-173	PCNA clamp associated factor	Rattus norvegicus	136-139
19689415-2	2009	PLA(2) constitute a diverse family of enzymes which catalyses the hydrolysis of the sn-2 ester bond in glycerophospholipids and exhibit a wide range of physiological and pathological effects.	Glycerophospholipids	103-123	phospholipase A2 group IB	Homo sapiens	0-6
18775417-1	2008	Phospholipase A(2) (PLA(2)) are esterases that cleave glycerophospholipids to release fatty acids and lysophospholipids.	Glycerophospholipids	54-74	phospholipase A2 group IB	Homo sapiens	20-26
18648767-1	2008	PURPOSES: Secretory phospholipase A2 hydrolyzes phosphoglycerides and it has been shown to be involved in alveolar inflammation and surfactant degradation.	Glycerophospholipids	48-65	phospholipase A2 group IB	Homo sapiens	20-36
18702510-2	2008	Dramatic differences in arachidonate (20:4 fatty acid)-containing lipids were observed for multiple classes of glycerophospholipids and polyphosphatidylinositides between wild-type and DGKepsilon knockout cells.	Glycerophospholipids	111-131	diacylglycerol kinase, epsilon	Mus musculus	185-195
18550892-0	2008	Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.	Glycerophospholipids	69-89	PCNA clamp associated factor	Homo sapiens	42-68
18550892-1	2008	The platelet-activating factor (PAF) family of glycerophospholipids accumulates in damaged brain tissue following injury.	Glycerophospholipids	47-67	PCNA clamp associated factor	Homo sapiens	4-30
18550892-1	2008	The platelet-activating factor (PAF) family of glycerophospholipids accumulates in damaged brain tissue following injury.	Glycerophospholipids	47-67	PCNA clamp associated factor	Homo sapiens	32-35
18991142-1	2008	As a transmembrane protein family, glycerophosphodiester phosphodiesterase (GDPD/GDE) catalyzes the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol.	Glycerophospholipids	125-145	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	81-84
18296342-3	2008	Liberation of these PUFA from the phosphoglycerides occurs via the action of specific phospholipases (PLA2).	Glycerophospholipids	34-51	phospholipase A2 group IB	Homo sapiens	102-106
18691015-1	2008	Group VI phospholipase A2 (PLA2) is a family of acyl hydrolases that targets the sn-2 fatty acid on the glycerophospholipid (GPL) backbone.	Glycerophospholipids	104-123	phospholipase A2 group VI	Homo sapiens	27-31
18691015-1	2008	Group VI phospholipase A2 (PLA2) is a family of acyl hydrolases that targets the sn-2 fatty acid on the glycerophospholipid (GPL) backbone.	Glycerophospholipids	125-128	phospholipase A2 group VI	Homo sapiens	27-31
18691015-2	2008	These enzymes are grouped together based on structural homologies and catalytic activities that are independent of calcium and hence are also called the iPLA(2)s. Although the best characterized of these enzymes, iPLA2beta and iPLA2gamma, have long been proposed as homeostatic enzymes involved in basal GPL metabolism, recent studies indicate roles for these enzymes in biomedically relevant processes as well.	Glycerophospholipids	304-307	phospholipase A2 group VI	Homo sapiens	213-222
18691015-2	2008	These enzymes are grouped together based on structural homologies and catalytic activities that are independent of calcium and hence are also called the iPLA(2)s. Although the best characterized of these enzymes, iPLA2beta and iPLA2gamma, have long been proposed as homeostatic enzymes involved in basal GPL metabolism, recent studies indicate roles for these enzymes in biomedically relevant processes as well.	Glycerophospholipids	304-307	patatin like phospholipase domain containing 8	Homo sapiens	227-237
18673210-1	2008	Secretory phospholipases A(2) (sPLA(2)s) are a subfamily of lipolytic enzymes which hydrolyze the acyl bond at the sn-2 position of glycerophospholipids to produce free fatty acids and lysophospholipids.	Glycerophospholipids	132-152	phospholipase A2 group IID	Homo sapiens	31-39
18443314-2	2008	This group includes patients with recently discovered mutations in the PLA2G6 gene encoding a calcium-independent phospholipase A2 enzyme that catalyzes the hydrolysis of glycerophospholipids.	Glycerophospholipids	171-191	phospholipase A2 group VI	Homo sapiens	71-77
18443314-2	2008	This group includes patients with recently discovered mutations in the PLA2G6 gene encoding a calcium-independent phospholipase A2 enzyme that catalyzes the hydrolysis of glycerophospholipids.	Glycerophospholipids	171-191	patatin like phospholipase domain containing 2	Homo sapiens	94-130
18296489-8	2008	These properties place Cer-1-P in a class more akin to certain glycerophospholipids (phosphatidylethanolamine, phosphatidic acid) than to any other sphingolipid.	Glycerophospholipids	63-83	cerberus 1, DAN family BMP antagonist	Homo sapiens	23-28
18287536-6	2008	We recently demonstrated that expression of the putative yeast sphingoid long-chain base transporter/translocase Rsb1 is induced when glycerophospholipid asymmetry is altered.	Glycerophospholipids	134-153	phospholipid-translocating ATPase RSB1	Saccharomyces cerevisiae S288C	113-117
18405237-1	2008	Phospholipases A(2) (PLA2s) are esterases that hydrolyze the sn-2 ester of glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes.	Glycerophospholipids	75-95	phospholipase A2 group IIA	Homo sapiens	21-26
17949058-0	2007	Identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high-performance liquid chromatography electrospray ionization tandem mass spectrometry.	Glycerophospholipids	87-107	PCNA clamp associated factor	Rattus norvegicus	50-76
17827229-2	2008	We explored what type of side group (small versus bulky groups, hydrophobic versus polar groups) can be introduced at the sn-1 position of the glycerol backbone of glycerophospholipids and at the same time be hydrolyzed by sPLA(2).	Glycerophospholipids	164-184	phospholipase A2 group IIA	Homo sapiens	223-229
17721743-2	2007	Platelet-activating factor (PAF) is an inflammatory biolipid produced from membrane glycerophospholipids.	Glycerophospholipids	84-104	PCNA clamp associated factor	Homo sapiens	0-26
17721743-2	2007	Platelet-activating factor (PAF) is an inflammatory biolipid produced from membrane glycerophospholipids.	Glycerophospholipids	84-104	PCNA clamp associated factor	Homo sapiens	28-31
17565722-1	2008	Phospholipase A(2) (PLA(2)) enzymes participate in a potent inflammatory pathway through the liberation of arachidonic acid upon hydrolysis of membrane glycerophospholipids.	Glycerophospholipids	152-172	phospholipase A2 group IB	Homo sapiens	0-18
17565722-1	2008	Phospholipase A(2) (PLA(2)) enzymes participate in a potent inflammatory pathway through the liberation of arachidonic acid upon hydrolysis of membrane glycerophospholipids.	Glycerophospholipids	152-172	phospholipase A2 group IB	Homo sapiens	20-26
17949058-2	2007	Synthesis of the platelet activating factor (PAF) glycerophospholipid subclass is implicated in the control of neuronal differentiation and death.	Glycerophospholipids	50-69	PCNA clamp associated factor	Rattus norvegicus	17-43
17949058-2	2007	Synthesis of the platelet activating factor (PAF) glycerophospholipid subclass is implicated in the control of neuronal differentiation and death.	Glycerophospholipids	50-69	PCNA clamp associated factor	Rattus norvegicus	45-48
17949058-3	2007	In this article, we combine nanoflow HPLC and mass spectrometry to screen, identify, and quantitate changes in glycerophospholipid subspecies, specifically PAF family members, over the course of neuronal differentiation.	Glycerophospholipids	111-130	PCNA clamp associated factor	Rattus norvegicus	156-159
17852048-1	2007	Arachidonic acid (AA) is generated in pancreatic beta-cells through the activation of Ca2+-dependent cytosolic phospholipase A2 (cPLA2) and the consequent hydrolysis of membrane phospholipids in the sn-2 position of the glycerophospholipid backbone.	Glycerophospholipids	220-239	phospholipase A2 group IVA	Homo sapiens	101-127
17393491-3	2007	Degradation of glycerophospholipids by phospholipase A(2) (PLA(2)) generates arachidonic acid (AA) and docosahexaenoic acids (DHA).	Glycerophospholipids	15-35	phospholipase A2 group IB	Homo sapiens	39-57
17393491-3	2007	Degradation of glycerophospholipids by phospholipase A(2) (PLA(2)) generates arachidonic acid (AA) and docosahexaenoic acids (DHA).	Glycerophospholipids	15-35	phospholipase A2 group IB	Homo sapiens	59-65
17675291-7	2007	Mass spectrometric analysis of lipids from slc1Delta and slc4Delta cells demonstrates that in vivo Slc1p and Slc4p generate almost the same glycerophospholipid profile.	Glycerophospholipids	140-159	1-acylglycerol-3-phosphate O-acyltransferase SLC1	Saccharomyces cerevisiae S288C	99-104
17675291-7	2007	Mass spectrometric analysis of lipids from slc1Delta and slc4Delta cells demonstrates that in vivo Slc1p and Slc4p generate almost the same glycerophospholipid profile.	Glycerophospholipids	140-159	lysophospholipid acyltransferase	Saccharomyces cerevisiae S288C	109-114
17675291-11	2007	Thus, Slc1p and Slc4p may not only be active as 1-acylglycerol-3-phosphate O-acyltransferases but also be involved in fatty acid exchange at the sn-2-position of mature glycerophospholipids.	Glycerophospholipids	169-189	1-acylglycerol-3-phosphate O-acyltransferase SLC1	Saccharomyces cerevisiae S288C	6-11
17675291-11	2007	Thus, Slc1p and Slc4p may not only be active as 1-acylglycerol-3-phosphate O-acyltransferases but also be involved in fatty acid exchange at the sn-2-position of mature glycerophospholipids.	Glycerophospholipids	169-189	lysophospholipid acyltransferase	Saccharomyces cerevisiae S288C	16-21
17531957-1	2007	Phospholipase A(2) (PLA(2)) are esterases that cleave glycerophospholipids to release fatty acids and lysophospholipids.	Glycerophospholipids	54-74	phospholipase A2 group IB	Homo sapiens	0-18
17531957-1	2007	Phospholipase A(2) (PLA(2)) are esterases that cleave glycerophospholipids to release fatty acids and lysophospholipids.	Glycerophospholipids	54-74	phospholipase A2 group IB	Homo sapiens	20-26
17690467-1	2007	Bacterial glycerophosphodiester phosphodiesterases (GP-PDEs), GlpQ and UgpQ, are well-characterized periplasmic and cytosolic proteins that play critical roles in the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol, which are utilized as major sources of carbon and phosphate.	Glycerophospholipids	192-212	glycerophosphodiester phosphodiesterase domain containing 4	Homo sapiens	71-75
17712822-4	2007	NAPE-PLD is a member of the metallo-beta-lactamase family, which specifically hydrolyzes NAPE among glycerophospholipids, and appears to be constitutively active.	Glycerophospholipids	100-120	N-acyl phosphatidylethanolamine phospholipase D	Rattus norvegicus	0-8
17393491-7	2007	Arachidonic acid, a product derived from glycerophospholipid catabolism by PLA(2), modulates sphingomyelinase (SMase), the enzyme that generates ceramide and phosphocholine.	Glycerophospholipids	41-60	phospholipase A2 group IB	Homo sapiens	75-81
17852048-1	2007	Arachidonic acid (AA) is generated in pancreatic beta-cells through the activation of Ca2+-dependent cytosolic phospholipase A2 (cPLA2) and the consequent hydrolysis of membrane phospholipids in the sn-2 position of the glycerophospholipid backbone.	Glycerophospholipids	220-239	phospholipase A2 group IVA	Homo sapiens	129-134
17419653-0	2007	Specific adsorption of cytochrome C on cardiolipin-glycerophospholipid monolayers and bilayers.	Glycerophospholipids	51-70	cytochrome c, somatic	Homo sapiens	23-35
17434532-6	2007	The impaired catalytic and interface binding functions implied by these structures provide a basis for the previous numerous observations of a biphasic dependence of the rate of PLA2 catalyzed hydrolysis of zwitterionic glycerophospholipids in the presence of bile salts.	Glycerophospholipids	220-240	phospholipase A2 group IB	Homo sapiens	178-182
17187824-0	2007	The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex.	Glycerophospholipids	58-78	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	4-9
17300923-13	2007	In comparison to wild-type littermates (Aldh5a1(+/+)), we detected a 20% reduction in the ethanolamine glycerophospholipid content of Aldh5a1(-/-)mice, while other brain phospholipids (choline glycerophospholipid, phosphatidylserine and phosphatidylinositol) were within normal limits.	Glycerophospholipids	103-122	aldhehyde dehydrogenase family 5, subfamily A1	Mus musculus	134-141
17182612-8	2007	Surprisingly, the enzyme catalyzed not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity).	Glycerophospholipids	155-175	PCNA clamp associated factor	Homo sapiens	60-63
17182612-8	2007	Surprisingly, the enzyme catalyzed not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity).	Glycerophospholipids	155-175	PCNA clamp associated factor	Homo sapiens	74-77
17182612-8	2007	Surprisingly, the enzyme catalyzed not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity).	Glycerophospholipids	155-175	PCNA clamp associated factor	Homo sapiens	74-77
17187824-6	2007	We also present here the crystal structure of this module with the Sec14 portion bound to a cellular glycerophospholipid ligand.	Glycerophospholipids	101-120	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	67-72
16962823-1	2006	Phospholipase A(2) (PLA(2)) (EC 3.1.1.4) catalyzes hydrolysis of the sn-2 ester bond of glycerophospholipids.	Glycerophospholipids	88-108	phospholipase A2 group IB	Homo sapiens	0-18
17174223-1	2007	Lipoprotein-associated PLA2 (Lp-PLA2) hydrolyses the sn-2 position of glycerophospholipids, in particular platelet activating factor (PAF), generating significant amounts of Lyso-PAF which in turn, via a remodelling pathway, can generate arachidonic acid (AA) from alkyl-acyl-glycerophosphorylcholine.	Glycerophospholipids	70-90	phospholipase A2 group VII	Homo sapiens	0-27
17174223-1	2007	Lipoprotein-associated PLA2 (Lp-PLA2) hydrolyses the sn-2 position of glycerophospholipids, in particular platelet activating factor (PAF), generating significant amounts of Lyso-PAF which in turn, via a remodelling pathway, can generate arachidonic acid (AA) from alkyl-acyl-glycerophosphorylcholine.	Glycerophospholipids	70-90	phospholipase A2 group VII	Homo sapiens	29-36
17197234-1	2007	We investigated the hydrolysis of the minor glycerophospholipids of human HDL(3), total HDL and LDL using human group IIA, V and X secretory phospholipases A(2) (sPLA(2)s).	Glycerophospholipids	44-64	HDL3	Homo sapiens	74-80
17197234-1	2007	We investigated the hydrolysis of the minor glycerophospholipids of human HDL(3), total HDL and LDL using human group IIA, V and X secretory phospholipases A(2) (sPLA(2)s).	Glycerophospholipids	44-64	phospholipase A2 group IID	Homo sapiens	162-170
17197234-6	2007	Surprisingly, the group IIA sPLA(2) hydrolysis remained minimal at 10-15% for all minor glycerophospholipids, and was of the order seen for the PtdCho hydrolysis by group IIA sPLA(2) at the 4-h digestion time.	Glycerophospholipids	88-108	phospholipase A2 group IIA	Homo sapiens	28-34
16962823-1	2006	Phospholipase A(2) (PLA(2)) (EC 3.1.1.4) catalyzes hydrolysis of the sn-2 ester bond of glycerophospholipids.	Glycerophospholipids	88-108	phospholipase A2 group IB	Homo sapiens	20-26
16916954-1	2006	Surfactant protein-A (SP-A) gene expression is developmentally regulated in fetal lung type II cells in concert with surfactant glycerophospholipid synthesis.	Glycerophospholipids	128-147	surfactant protein A1	Homo sapiens	0-20
16916954-1	2006	Surfactant protein-A (SP-A) gene expression is developmentally regulated in fetal lung type II cells in concert with surfactant glycerophospholipid synthesis.	Glycerophospholipids	128-147	surfactant protein A1	Homo sapiens	22-26
16564042-1	2006	Phospholipase A2 (PLA2) is an esterase that cleaves the sn-2 ester bond in glycerophospholipids, thereby releasing free fatty acids and lysophospholipids.	Glycerophospholipids	75-95	phospholipase A2, group IB, pancreas	Mus musculus	0-16
16754327-2	2006	The PC and other glycerophospholipid compositions of membranes change dynamically through stimulus-dependent and independent pathways, principally by the action of two different types of enzymes; phospholipase A2 [EC 3.1.1.4] and acyl-CoA:lysophospholipid acyltransferase [EC 2.3.1.23].	Glycerophospholipids	17-36	phospholipase A2 group IB	Homo sapiens	196-212
16754327-3	2006	Phospholipase A2 is a key enzyme that catalyzes deacylation of the sn-2 position of glycerophospholipids.	Glycerophospholipids	84-104	phospholipase A2 group IB	Homo sapiens	0-16
16864779-8	2006	Antigen-binding analyses confirm that selected TCL1 clones react with glycerophospholipid, lipoprotein, and polysaccharides that can be autoantigens and be expressed by microbes.	Glycerophospholipids	70-89	TCL1 family AKT coactivator A	Homo sapiens	47-51
16564042-1	2006	Phospholipase A2 (PLA2) is an esterase that cleaves the sn-2 ester bond in glycerophospholipids, thereby releasing free fatty acids and lysophospholipids.	Glycerophospholipids	75-95	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	18-22
16489752-1	2006	Secreted phospholipases A2 (sPLA2"s) are enzymes that hydrolyze glycerophospholipids at the sn-2 position, which leads to the production of lipid mediators of many cellular processes.	Glycerophospholipids	64-84	phospholipase A2 group IID	Homo sapiens	28-35
15866882-1	2005	Phospholipase A(2) hydrolyzes the sn-2 ester bond of glycerophospholipids that produce free fatty acids and lysophospholipids.	Glycerophospholipids	53-73	phospholipase A2, group IB, pancreas	Mus musculus	0-18
16007182-10	2005	Finally, activation of Akt induces an increase in the concentration of cellular fatty acids as well as phosphoglycerides, the components of cellular membranes.	Glycerophospholipids	103-120	AKT serine/threonine kinase 1	Homo sapiens	23-26
16000584-1	2005	PURPOSE: Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is a transmembrane enzyme critical for the biosynthesis of phosphoglycerides whose product, phosphatidic acid, plays a key role in raf and AKT/mTor-mediated signal transduction.	Glycerophospholipids	124-141	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	9-51
16000584-1	2005	PURPOSE: Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is a transmembrane enzyme critical for the biosynthesis of phosphoglycerides whose product, phosphatidic acid, plays a key role in raf and AKT/mTor-mediated signal transduction.	Glycerophospholipids	124-141	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	53-63
16000584-1	2005	PURPOSE: Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is a transmembrane enzyme critical for the biosynthesis of phosphoglycerides whose product, phosphatidic acid, plays a key role in raf and AKT/mTor-mediated signal transduction.	Glycerophospholipids	124-141	zinc fingers and homeoboxes 2	Homo sapiens	196-199
16000584-1	2005	PURPOSE: Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is a transmembrane enzyme critical for the biosynthesis of phosphoglycerides whose product, phosphatidic acid, plays a key role in raf and AKT/mTor-mediated signal transduction.	Glycerophospholipids	124-141	AKT serine/threonine kinase 1	Homo sapiens	204-207
16000584-1	2005	PURPOSE: Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is a transmembrane enzyme critical for the biosynthesis of phosphoglycerides whose product, phosphatidic acid, plays a key role in raf and AKT/mTor-mediated signal transduction.	Glycerophospholipids	124-141	mechanistic target of rapamycin kinase	Homo sapiens	208-212
16271262-0	2005	alpha-Lactalbumin binding and membrane integrity--effect of charge and degree of unsaturation of glycerophospholipids.	Glycerophospholipids	97-117	lactalbumin alpha	Homo sapiens	0-17
16271262-2	2005	We have investigated the influence of the interaction of the calcium-depleted, (apo)-conformation of bovine alpha-lactalbumin (BLA) on the integrity of anionic glycerophospholipid vesicles by leakage experiments using fluorescence spectroscopy.	Glycerophospholipids	160-179	lactalbumin alpha	Bos taurus	108-125
16115865-6	2005	We have identified 3 groups of lipids that stimulate proteolytic activity of BACE: 1) neutral glycosphingolipids (cerebrosides), 2) anionic glycerophospholipids, and 3) sterols (cholesterol).	Glycerophospholipids	140-160	beta-secretase 1	Homo sapiens	77-84
16200394-8	2005	Thus, using information on the known molecular structures of tested phospholipids, a phosphatidylcholine residue in alpha-position and a short chain length fatty acid esterified in beta-position seem essential for activation of ecto-5"-nucleotidase by glycerophospholipids.	Glycerophospholipids	252-272	5'-nucleotidase ecto	Homo sapiens	228-248
15950537-1	2005	In order to find out whether there is a phospholipase A2 (PLA2)-mediated link between glycerophospholipids and sphingolipids, L929 cells were labeled with 1n-palmitoyl-2n-[1-14C]palmitoyl phosphatidylcholine for 16-18 h or 90 min.	Glycerophospholipids	86-106	phospholipase A2, group IB, pancreas	Mus musculus	40-56
15829484-3	2005	In the present study, we found that Scd1 deficiency significantly modulates hepatic glycerophospholipid profile.	Glycerophospholipids	84-103	stearoyl-Coenzyme A desaturase 1	Mus musculus	36-40
15950537-1	2005	In order to find out whether there is a phospholipase A2 (PLA2)-mediated link between glycerophospholipids and sphingolipids, L929 cells were labeled with 1n-palmitoyl-2n-[1-14C]palmitoyl phosphatidylcholine for 16-18 h or 90 min.	Glycerophospholipids	86-106	phospholipase A2, group IB, pancreas	Mus musculus	58-62
15342785-8	2004	Expression of Rsb1p also was enhanced in mutants for the genes involved in the flip of glycerophospholipids, including ROS3, DNF1, and DNF2.	Glycerophospholipids	87-107	phospholipid-translocating ATPase RSB1	Saccharomyces cerevisiae S288C	14-19
15545826-1	2004	Platelet-activating factor (PAF), a glycerophospholipid with proinflammatory properties, exerts its biological effects by interacting with the PAF receptor (PAFR) expressed on many different cell types.	Glycerophospholipids	36-55	patchy fur	Mus musculus	0-26
15545826-1	2004	Platelet-activating factor (PAF), a glycerophospholipid with proinflammatory properties, exerts its biological effects by interacting with the PAF receptor (PAFR) expressed on many different cell types.	Glycerophospholipids	36-55	patchy fur	Mus musculus	28-31
15545826-1	2004	Platelet-activating factor (PAF), a glycerophospholipid with proinflammatory properties, exerts its biological effects by interacting with the PAF receptor (PAFR) expressed on many different cell types.	Glycerophospholipids	36-55	platelet-activating factor receptor	Mus musculus	143-155
15545826-1	2004	Platelet-activating factor (PAF), a glycerophospholipid with proinflammatory properties, exerts its biological effects by interacting with the PAF receptor (PAFR) expressed on many different cell types.	Glycerophospholipids	36-55	platelet-activating factor receptor	Mus musculus	157-161
15494434-3	2005	Secretory phospholipase A2 (sPLA2), which hydrolyzes the sn-2 ester bond of glycerophospholipids, regulates a variety of cellular functions including migration of endothelial cells and neurite outgrowth.	Glycerophospholipids	76-96	phospholipase A2 group X	Homo sapiens	0-26
15494434-3	2005	Secretory phospholipase A2 (sPLA2), which hydrolyzes the sn-2 ester bond of glycerophospholipids, regulates a variety of cellular functions including migration of endothelial cells and neurite outgrowth.	Glycerophospholipids	76-96	phospholipase A2 group X	Homo sapiens	28-33
15737611-0	2005	Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme.	Glycerophospholipids	16-35	sphingosine-1-phosphate lyase 1	Homo sapiens	50-53
15737611-3	2005	In the present study, SPL-null F9 cells were able to convert radiolabeled dihydrosphingosine to glycerophospholipids, albeit at much lower efficiency than parent cells.	Glycerophospholipids	96-116	sphingosine-1-phosphate lyase 1	Homo sapiens	22-25
15504403-1	2004	Phospholipase A(2) (PLA(2)) hydrolyzes glycerophospholipids to free fatty acid and lyso-phospholipid, which serve as precursors for the biosynthesis of eicosanoids and other lipid-derived mediators of inflammation and allergy.	Glycerophospholipids	39-59	phospholipase A2 group IB	Homo sapiens	0-18
15504403-1	2004	Phospholipase A(2) (PLA(2)) hydrolyzes glycerophospholipids to free fatty acid and lyso-phospholipid, which serve as precursors for the biosynthesis of eicosanoids and other lipid-derived mediators of inflammation and allergy.	Glycerophospholipids	39-59	phospholipase A2 group IB	Homo sapiens	20-26
15342785-8	2004	Expression of Rsb1p also was enhanced in mutants for the genes involved in the flip of glycerophospholipids, including ROS3, DNF1, and DNF2.	Glycerophospholipids	87-107	Lem3p	Saccharomyces cerevisiae S288C	119-123
15342785-8	2004	Expression of Rsb1p also was enhanced in mutants for the genes involved in the flip of glycerophospholipids, including ROS3, DNF1, and DNF2.	Glycerophospholipids	87-107	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	125-129
15342785-8	2004	Expression of Rsb1p also was enhanced in mutants for the genes involved in the flip of glycerophospholipids, including ROS3, DNF1, and DNF2.	Glycerophospholipids	87-107	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	135-139
15342785-9	2004	These results suggest that altered glycerophospholipid asymmetry induces the expression of Rsb1p.	Glycerophospholipids	35-54	phospholipid-translocating ATPase RSB1	Saccharomyces cerevisiae S288C	91-96
15342785-10	2004	Conversely, overexpression of Rsb1p resulted in increased flip and decreased flop of fluorescence-labeled glycerophospholipids.	Glycerophospholipids	106-126	phospholipid-translocating ATPase RSB1	Saccharomyces cerevisiae S288C	30-35
15450207-1	2004	Several lines of evidence suggest that glycerophospholipid mass is maintained through the coordinate regulation of CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) and the group VIA calcium-independent phospholipase A2 (iPLA2).	Glycerophospholipids	39-58	choline-phosphate cytidylyltransferase A	Cricetulus griseus	115-160
15450207-1	2004	Several lines of evidence suggest that glycerophospholipid mass is maintained through the coordinate regulation of CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) and the group VIA calcium-independent phospholipase A2 (iPLA2).	Glycerophospholipids	39-58	choline-phosphate cytidylyltransferase A	Cricetulus griseus	162-169
15358156-1	2004	Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) catalyzes the hydrolysis of glycerophospholipids at the sn-2 position to liberate fatty acids.	Glycerophospholipids	77-97	phospholipase A2 group IVA	Homo sapiens	35-47
15450207-1	2004	Several lines of evidence suggest that glycerophospholipid mass is maintained through the coordinate regulation of CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) and the group VIA calcium-independent phospholipase A2 (iPLA2).	Glycerophospholipids	39-58	phospholipase A2	Cricetulus griseus	209-225
15155618-1	2004	Acyloxyacyl hydrolase (AOAH) is an unusual but highly conserved lipase, previously described only in myeloid cells, that removes secondary fatty acyl chains from bacterial lipopolysaccharides (LPS) and may also act on various glycero(phospho)lipids.	Glycerophospholipids	226-248	acyloxyacyl hydrolase	Mus musculus	0-21
15155618-1	2004	Acyloxyacyl hydrolase (AOAH) is an unusual but highly conserved lipase, previously described only in myeloid cells, that removes secondary fatty acyl chains from bacterial lipopolysaccharides (LPS) and may also act on various glycero(phospho)lipids.	Glycerophospholipids	226-248	acyloxyacyl hydrolase	Mus musculus	23-27
14676189-0	2004	Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids.	Glycerophospholipids	98-118	mitogen-activated protein kinase kinase 7	Homo sapiens	18-21
14726513-7	2004	The viral PLA(2)s did not display a preference for unsaturated versus saturated sn-2 fatty acyl chains and hydrolyzed all major classes of glycero-phospholipids except phosphatidylinositol.	Glycerophospholipids	139-160	phospholipase A2 group IIA	Homo sapiens	10-17
14676189-0	2004	Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids.	Glycerophospholipids	98-118	zinc fingers and homeoboxes 2	Homo sapiens	14-17
14676189-0	2004	Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids.	Glycerophospholipids	98-118	mitogen-activated protein kinase 1	Homo sapiens	22-25
14676189-0	2004	Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids.	Glycerophospholipids	98-118	phospholipase A2 group IVA	Homo sapiens	26-31
14676189-2	2004	Here we report that activation of the host Raf-MEK-ERK-cPLA2 signaling cascade is required for the chlamydial uptake of host glycerophospholipids.	Glycerophospholipids	125-145	zinc fingers and homeoboxes 2	Homo sapiens	43-46
14676189-2	2004	Here we report that activation of the host Raf-MEK-ERK-cPLA2 signaling cascade is required for the chlamydial uptake of host glycerophospholipids.	Glycerophospholipids	125-145	mitogen-activated protein kinase kinase 7	Homo sapiens	47-50
14676189-2	2004	Here we report that activation of the host Raf-MEK-ERK-cPLA2 signaling cascade is required for the chlamydial uptake of host glycerophospholipids.	Glycerophospholipids	125-145	mitogen-activated protein kinase 1	Homo sapiens	51-54
14676189-2	2004	Here we report that activation of the host Raf-MEK-ERK-cPLA2 signaling cascade is required for the chlamydial uptake of host glycerophospholipids.	Glycerophospholipids	125-145	phospholipase A2 group IVA	Homo sapiens	55-60
14676189-4	2004	The inhibition of cPLA2 activity resulted in the blockade of the chlamydial uptake of host glycerophospholipids and impairment in chlamydial growth.	Glycerophospholipids	91-111	phospholipase A2 group IVA	Homo sapiens	18-23
14676189-5	2004	Blocking either c-Raf-1 or MEK1/2 activity prevented the chlamydial activation of ERK1/2, leading to the suppression of both chlamydial activation of the host cPLA2 and uptake of glycerophospholipids from the host cells.	Glycerophospholipids	179-199	TNF receptor associated factor 3	Homo sapiens	16-23
14676189-5	2004	Blocking either c-Raf-1 or MEK1/2 activity prevented the chlamydial activation of ERK1/2, leading to the suppression of both chlamydial activation of the host cPLA2 and uptake of glycerophospholipids from the host cells.	Glycerophospholipids	179-199	mitogen-activated protein kinase kinase 1	Homo sapiens	27-33
14676189-5	2004	Blocking either c-Raf-1 or MEK1/2 activity prevented the chlamydial activation of ERK1/2, leading to the suppression of both chlamydial activation of the host cPLA2 and uptake of glycerophospholipids from the host cells.	Glycerophospholipids	179-199	mitogen-activated protein kinase 3	Homo sapiens	82-88
15052340-1	2004	Phospholipase D catalyses the hydrolysis of the phosphodiester bond of glycerophospholipids to generate phosphatidic acid and a free headgroup.	Glycerophospholipids	71-91	phospholipase D	Saccharomyces cerevisiae S288C	0-15
12925201-3	2003	To test the hypothesis that ABC molecules are potentially involved in the epidermal transport of sphingolipids, glycerophospholipids, cholesterol, and fatty acids, we performed mRNA expression profiling of all currently known ABC molecules during in vitro differentiation of human keratinocytes and HaCaT cells.	Glycerophospholipids	112-132	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	28-31
14557833-3	2004	The AGPAT2 catalyses the acylation of the lysophosphatidic acid at the sn-2 position to form phosphatidic acid, a key intermediate in the biosynthesis of triacylglycerol and glycerophospholipids.	Glycerophospholipids	174-194	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	4-10
14717583-6	2004	Reconstitution of POG-Tbetagamma with Talpha and light-activated rhodopsin (Rh) in photoreceptor membranes resulted in cross-linking of Tgamma with a glycerophospholipid, indicating molecular interaction of the farnesyl group with cellular membranes.	Glycerophospholipids	150-169	rhodopsin	Homo sapiens	65-74
14552885-3	2003	The enzyme cPLA(2) hydrolyzes neural membrane glycerophospholipids and generates precursors for proinflammatory mediators.	Glycerophospholipids	46-66	phospholipase A2 group IVA	Homo sapiens	11-18
12924217-1	2003	A possibility is studied of the transdermal delivery of insulin by using a mixture of synthetic analogues of phosphoglycerides (SAP), as a potential activator of hormone diffusion, through the skin.	Glycerophospholipids	109-126	insulin	Homo sapiens	56-63
14567187-1	2003	Phospholipases A2 (PLA2) are enzymes that catalyse the hydrolysis of glycerophospholipids at the sn-2 position, generating free fatty acids and lysophospholipids.	Glycerophospholipids	69-89	phospholipase A2 group IB	Homo sapiens	19-23
12765847-1	2003	Phospholipase A2, Group IVA (PLA2G4A) belongs to the class of cytosolic calcium-dependent phospholipases (cPLA2s) that preferentially cleave arachidonic acid (AA) from membrane glycerophospholipids.	Glycerophospholipids	177-197	phospholipase A2 group IVA	Homo sapiens	0-27
12765847-1	2003	Phospholipase A2, Group IVA (PLA2G4A) belongs to the class of cytosolic calcium-dependent phospholipases (cPLA2s) that preferentially cleave arachidonic acid (AA) from membrane glycerophospholipids.	Glycerophospholipids	177-197	phospholipase A2 group IVA	Homo sapiens	29-36
12502717-3	2003	Phospholipase A(2) (PLA(2)), with hydrolytic enzyme activities at the sn-2 position in glycerophospholipids, plays critical roles in maintaining the phospholipid composition as well as producing bioactive lipid mediators.	Glycerophospholipids	87-107	phospholipase A2 group IB	Homo sapiens	0-18
12502717-3	2003	Phospholipase A(2) (PLA(2)), with hydrolytic enzyme activities at the sn-2 position in glycerophospholipids, plays critical roles in maintaining the phospholipid composition as well as producing bioactive lipid mediators.	Glycerophospholipids	87-107	phospholipase A2 group IB	Homo sapiens	20-26
12518029-3	2003	Unanesthetized cPLA(2)(-/-) mice had reduced rates of incorporation of unlabeled arachidonate from plasma and from the brain arachidonoyl-CoA pool into ethanolamine glycerophospholipid and choline glycerophospholipid, but elevated rates into phosphatidylinositol.	Glycerophospholipids	165-184	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	15-21
12669822-12	2003	Via chain-shortening, VLCPUFA stored in the neutral lipids may serve as precursors of the major C22 PUFA typical of cell membrane glycerophospholipids, protecting testicular cells against shifts in FA composition induced by dietary changes.	Glycerophospholipids	130-150	pumilio RNA binding family member 3	Homo sapiens	25-29
12573364-5	2002	sPLA(2) is calcium-dependent and hydrolyses the sn-2 acyl group of glycerophospholipids of lipoproteins and cell membranes to produce lyso-PC and free fatty acids.	Glycerophospholipids	67-87	phospholipase A2 group IIA	Homo sapiens	0-7
12531539-1	2002	Phospolipase A(2) (PLA(2)) is the esterase activity that cleaves the sn-2 ester bond in glycerophospholipids, releasing free fatty acids and lysophospholipids.	Glycerophospholipids	88-108	phospholipase A2 group IIA	Homo sapiens	0-17
12531539-1	2002	Phospolipase A(2) (PLA(2)) is the esterase activity that cleaves the sn-2 ester bond in glycerophospholipids, releasing free fatty acids and lysophospholipids.	Glycerophospholipids	88-108	phospholipase A2 group IIA	Homo sapiens	19-25
12406338-2	2002	They serve an anti-inflammatory function by converting the proinflammatory autocoid, PAF, into biologically inactive lyso-PAF, by the removal of the sn-2 acetyl group of this glycerophospholipid.	Glycerophospholipids	175-194	PCNA clamp associated factor	Homo sapiens	85-88
12406338-2	2002	They serve an anti-inflammatory function by converting the proinflammatory autocoid, PAF, into biologically inactive lyso-PAF, by the removal of the sn-2 acetyl group of this glycerophospholipid.	Glycerophospholipids	175-194	PCNA clamp associated factor	Homo sapiens	122-125
12432908-1	2002	Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes.	Glycerophospholipids	82-102	phospholipase A2 group IB	Homo sapiens	0-16
12432908-1	2002	Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes.	Glycerophospholipids	82-102	phospholipase A2 group IB	Homo sapiens	18-22
11967537-3	2002	The AGPAT2 enzyme catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in the biosynthesis of triacylglycerol and glycerophospholipids.	Glycerophospholipids	156-176	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	4-10
11953426-6	2002	Interactions of Raf with cholesterol are of particular interest, since cholesterol has been shown to be involved, together with sphingomyelin and glycerophospholipids in the formation of specialized lipid microdomains called rafts.	Glycerophospholipids	146-166	zinc fingers and homeoboxes 2	Homo sapiens	16-19
11486733-2	2001	SP-A interacts with a broad range of amphipathic lipids (glycerophospholipids, sphingophospholipids, glycosphingolipids, lipid A, and lipoglycans) that are present in surfactant or microbial membranes.	Glycerophospholipids	57-77	surfactant protein A1	Homo sapiens	0-4
11872155-1	2002	Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins (PGs) and leukotrienes (LTs).	Glycerophospholipids	82-102	phospholipase A2 group IB	Homo sapiens	0-16
11872155-1	2002	Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins (PGs) and leukotrienes (LTs).	Glycerophospholipids	82-102	phospholipase A2 group IB	Homo sapiens	18-22
11499402-1	2001	Plasmalogens are unique glycerophospholipids because they have an enol ether double bond at the sn-1 position of the glycerol backbone.	Glycerophospholipids	24-44	solute carrier family 38 member 3	Homo sapiens	96-100
11387200-5	2001	lag1lac1 cells compensate for the lack of normal sphingolipids by making increased amounts of C26 fatty acids, which become incorporated into glycerophospholipids.	Glycerophospholipids	142-162	sphingosine N-acyltransferase LAG1	Saccharomyces cerevisiae S288C	0-8
10973999-12	2000	Annexin II promotes the Ca(2+)-dependent association of lipid raft microdomains, whereas annexin V interacts with glycerophospholipid microcompartments.	Glycerophospholipids	114-133	annexin A5	Homo sapiens	89-98
11469536-2	2001	Secretory type IIA PLA2 (sPLA2-IIA), which hydrolyzes fatty acids bound at the sn-2 position of glycerophospholipids, has been detected universally in a variety of mammalian tissues and cells.	Glycerophospholipids	96-116	phospholipase A2 group IIA	Homo sapiens	19-23
11112347-5	2000	Glycerol 3-phosphate (G3P) is produced by glycerol kinase (GK) and is found in several biochemical pathways in different cellular compartments, such as the glycerol phosphate shuttle and glycerophospholipid synthesis.	Glycerophospholipids	187-206	glycerol kinase	Homo sapiens	59-61
11080677-4	2000	All of these sPLA(2)s catalyze the hydrolysis of glycerophospholipids at the sn-2 position to release free fatty acids and lysophospholipids, and thus could be important for the biosynthesis of biologically active lipid mediators.	Glycerophospholipids	49-69	phospholipase A2 group IIA	Homo sapiens	13-19
11111912-9	2000	The high lateral mobility within the phosphoglyceride region of the plasma membrane favors the encounter of the protoxin with its converting enzyme furin.	Glycerophospholipids	37-53	furin, paired basic amino acid cleaving enzyme	Homo sapiens	148-153
11161822-5	2001	These decreased brain 22:6n-3 concentrations appear to be secondary to impaired plasmalogen (sn-1-alkyl-, alkenyl-2-acyl glycerophospholipids) synthesis, probably at the level of the dihydroxyacetonephosphate acyltransferase (DHAP-AT), a peroxisomal enzyme catalyzing the first step in the synthesis of 22:6n-3-rich plasmalogens.	Glycerophospholipids	121-141	glyceronephosphate O-acyltransferase	Mus musculus	183-224
11162354-2	2001	Type II phospholipase A(2)(PLA2) hydrolyses glycerophospholipids, releasing free fatty acid for conversion into potent biological mediators, such as prostaglandins, which play a significant role in both the onset and progression of human labour and the activation of inflammatory reactions.	Glycerophospholipids	44-64	phospholipase A2 group IIA	Homo sapiens	27-31
10846187-1	2000	A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.	Glycerophospholipids	139-159	amyloid beta (A4) precursor protein	Mus musculus	34-39
10846187-9	2000	This fraction from two independent lines of mutant PS2 transgenic mice contained remarkably increased levels of Abeta42 and significantly low levels of glycerophospholipids and sphingomyelin.	Glycerophospholipids	152-172	presenilin 2	Mus musculus	51-54
10984188-7	2000	A lysophospholipid, the second product of reactions catalyzed by phospholipase A2, is rapidly acylated with acyl-CoA, resulting in the maintenance of the normal and essential neural membrane glycerophospholipid composition.	Glycerophospholipids	191-210	phospholipase A2 group IB	Homo sapiens	65-81
11011072-1	2000	Phospholipase A(2) catalyzes the hydrolysis of membrane glycerophospholipids leading to the production of metabolites observable by both 1H and 31P magnetic resonance spectroscopy.	Glycerophospholipids	56-76	phospholipase A2 group IB	Homo sapiens	0-18
10941873-4	2000	L-FABP expression increased the masses of choline glycerophospholipids (ChoGpl) 1.5-fold, phosphatidylserine (PtdSer) 5.6-fold, ethanolamine glycerophospholipids 1.4-fold, sphingomyelin 1.7-fold, and phosphatidylinositol 2.6-fold.	Glycerophospholipids	50-70	fatty acid binding protein 1	Homo sapiens	0-6
10795906-2	2000	The two major enzyme systems involved are cytosolic phospholipase A2 (cPLA2), which catalyses the formation of arachidonic acid from membrane glycerophospholipids, and prostaglandin endoperoxide-H synthases-1 and -2, which allow conversion of arachidonic acid to prostaglandins.	Glycerophospholipids	142-162	cytosolic phospholipase A2	Oryctolagus cuniculus	42-68
10795906-2	2000	The two major enzyme systems involved are cytosolic phospholipase A2 (cPLA2), which catalyses the formation of arachidonic acid from membrane glycerophospholipids, and prostaglandin endoperoxide-H synthases-1 and -2, which allow conversion of arachidonic acid to prostaglandins.	Glycerophospholipids	142-162	cytosolic phospholipase A2	Oryctolagus cuniculus	70-75
10329351-3	1999	In the amnion, the liberation of arachidonic acid from membrane glycerophospholipid stores can be catalysed by cytosolic phospholipase A2 (cPLA2).	Glycerophospholipids	64-83	phospholipase A2 group IVA	Homo sapiens	111-137
10721895-2	2000	The expression of fatty acid synthase, which catalyzes all reactions for synthesis of palmitate from acetyl-CoA and malonyl-CoA, and of mitochondrial glycerol-3-phosphate acyltransferase, which catalyzes the first acylation step in glycerophospholipid synthesis, is decreased to an undetectable level during fasting.	Glycerophospholipids	232-251	fatty acid synthase	Mus musculus	18-37
10385648-6	1999	Biliary PAF-AH hydrolyzed also the truncated sn-2-succinoyl and sn-2-glutaroyl analogs of PAF, indicating a broader activity of PAF-AH in bile toward byproducts of glycerophospholipid peroxidation.	Glycerophospholipids	164-183	phospholipase A2 group VII	Rattus norvegicus	8-14
10385648-6	1999	Biliary PAF-AH hydrolyzed also the truncated sn-2-succinoyl and sn-2-glutaroyl analogs of PAF, indicating a broader activity of PAF-AH in bile toward byproducts of glycerophospholipid peroxidation.	Glycerophospholipids	164-183	PCNA clamp associated factor	Rattus norvegicus	8-11
10385648-6	1999	Biliary PAF-AH hydrolyzed also the truncated sn-2-succinoyl and sn-2-glutaroyl analogs of PAF, indicating a broader activity of PAF-AH in bile toward byproducts of glycerophospholipid peroxidation.	Glycerophospholipids	164-183	phospholipase A2 group VII	Rattus norvegicus	128-134
10407787-11	1999	Sequence homology of the TAZ gene to a highly conserved superclass of acyltransferases (Neuwald"s hypothesis) predicts a glycerophospholipid as the missing end product.	Glycerophospholipids	121-140	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	25-28
10591080-1	1999	Phospholipase A2 (PLA2) enzymes cleave esterified fatty acids from membrane glycerophospholipids.	Glycerophospholipids	76-96	phospholipase A2 group IB	Homo sapiens	0-16
10591080-1	1999	Phospholipase A2 (PLA2) enzymes cleave esterified fatty acids from membrane glycerophospholipids.	Glycerophospholipids	76-96	phospholipase A2 group IB	Homo sapiens	18-22
10447683-10	1999	It was concluded that C6-ceramide affected glycerophospholipid synthesis predominantly by inhibition of the step in the CDP-pathways catalysed by cholinephosphotransferase and ethanolaminephosphotransferase.	Glycerophospholipids	43-62	cut-like homeobox 1	Rattus norvegicus	120-123
10329351-3	1999	In the amnion, the liberation of arachidonic acid from membrane glycerophospholipid stores can be catalysed by cytosolic phospholipase A2 (cPLA2).	Glycerophospholipids	64-83	phospholipase A2 group IVA	Homo sapiens	139-144
9370312-1	1997	Glycerol-3-phosphate acyltransferase (GPAT) is the first committed, and presumed to be a rate-limiting, step in glycerophospholipid biosynthesis.	Glycerophospholipids	112-131	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	0-36
10198045-7	1999	We propose that in lymphocyte plasma membranes, Lck and Fyn kinases exhibit optimal activity when juxtaposed to the GPI- and sphingolipid-enriched core microdomains but encounter inhibitory conditions in surrounding membrane areas that are rich in glycerophospholipids and contain additional transmembrane proteins.	Glycerophospholipids	248-268	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	48-51
10198045-7	1999	We propose that in lymphocyte plasma membranes, Lck and Fyn kinases exhibit optimal activity when juxtaposed to the GPI- and sphingolipid-enriched core microdomains but encounter inhibitory conditions in surrounding membrane areas that are rich in glycerophospholipids and contain additional transmembrane proteins.	Glycerophospholipids	248-268	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
9799801-8	1998	Group IIA phospholipase A2 preferentially attacked the hydroxy and hydroperoxy linoleates and possibly other oxygenated fatty acids, which were released from the glycerophospholipids at early times of incubation.	Glycerophospholipids	162-182	phospholipase A2 group IIA	Homo sapiens	0-26
9593672-2	1998	Guinea pig intestinal phospholipase B is a calcium-independent phospholipase hydrolyzing sequentially the acyl ester bonds at sn-2 and sn-1 positions of glycerophospholipids, promoting the formation of sn-glycero-3-phosphocholine from phosphatidylcholine.	Glycerophospholipids	153-173	phospholipase B1, membrane-associated	Cavia porcellus	22-37
9419344-5	1998	LBP1 was cloned from a yeast mutant that accumulated phosphorylated long-chain sphingoid bases and diverted sphingoid base intermediates from sphingolipid pathways to glycerophospholipid biosynthesis.	Glycerophospholipids	167-186	sphinganine kinase LCB3	Saccharomyces cerevisiae S288C	0-4
10410380-2	1999	It is our hypothesis that platelet-activating factor (PAF), a potent glycerophospholipid that acts as a chemical mediator for a wide spectrum of biological activities, including increased vascular permeability, may be produced in significant amounts during periods preceding microalbuminuria.	Glycerophospholipids	69-88	PCNA clamp associated factor	Homo sapiens	26-52
10410380-2	1999	It is our hypothesis that platelet-activating factor (PAF), a potent glycerophospholipid that acts as a chemical mediator for a wide spectrum of biological activities, including increased vascular permeability, may be produced in significant amounts during periods preceding microalbuminuria.	Glycerophospholipids	69-88	PCNA clamp associated factor	Homo sapiens	54-57
10322502-1	1999	Phospholipases A2 (PLA2s) are enzymes that catalyse the hydrolysis of the sn-2 acyl bond of glycerophospholipids to produce free fatty acids and lysophospholipids.	Glycerophospholipids	92-112	phospholipase A2 group IIA	Homo sapiens	19-24
9733716-3	1998	Phosphatidylserine (PS), another anionic glycerophospholipid, binds to mCD14 with lower apparent affinity than does PtdIns.	Glycerophospholipids	41-60	CD14 antigen	Mus musculus	71-76
9610765-8	1998	Transfer of glycerophospholipids onto apoA-II was much lower than onto apoA-I; transfer onto albumin was close to background.	Glycerophospholipids	12-32	apolipoprotein A2	Homo sapiens	38-45
9610765-8	1998	Transfer of glycerophospholipids onto apoA-II was much lower than onto apoA-I; transfer onto albumin was close to background.	Glycerophospholipids	12-32	apolipoprotein A1	Homo sapiens	38-44
9480813-5	1998	Glycerophospholipid remodeling in CCL16-B2 cells, a mitochondrial respiration mutant with elevated glycerophospholipid metabolism, was compared to its parental cell line CCL16-B1 infected with C. trachomatis.	Glycerophospholipids	0-19	LOW QUALITY PROTEIN: C-C motif chemokine 16	Cricetulus griseus	34-39
9480813-6	1998	Infection of the wild type CCL16-B1 cells with C. trachomatis resulted in an almost identical pattern of [1-14C]-palmitate labeling of glycerophospholipids compared to the uninfected mitochondrial mutant CCL16-B2 cells.	Glycerophospholipids	135-155	LOW QUALITY PROTEIN: C-C motif chemokine 16	Cricetulus griseus	27-32
9481780-2	1998	The aims of this brief commentary are: (1) to review recent data concerning the expression of secretory PLA2 isozymes in human gestational tissues; and (2) to present a case for their involvement in regulating the expression of glycerophospholipids in the exoplasmic monolayer of the cell membrane.	Glycerophospholipids	228-248	phospholipase A2 group IIA	Homo sapiens	104-108
9481783-1	1998	Recently, a model has been proposed for the involvement of secretory phospholipase A2 (sPLA2) in the onset of and/or progression of human labour via the metabolism of cell membrane glycerophospholipids to generate biologically active, phospholipid-derived mediators.	Glycerophospholipids	181-201	phospholipase A2 group IIA	Homo sapiens	59-85
9481783-1	1998	Recently, a model has been proposed for the involvement of secretory phospholipase A2 (sPLA2) in the onset of and/or progression of human labour via the metabolism of cell membrane glycerophospholipids to generate biologically active, phospholipid-derived mediators.	Glycerophospholipids	181-201	phospholipase A2 group IIA	Homo sapiens	87-92
9370312-1	1997	Glycerol-3-phosphate acyltransferase (GPAT) is the first committed, and presumed to be a rate-limiting, step in glycerophospholipid biosynthesis.	Glycerophospholipids	112-131	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	38-42
9282910-1	1997	Phospholipase A2 (PLA2) is the name for the class of lipolytic enzymes that hydrolyze the acyl group from the sn-2 position of glycerophospholipids, generating free fatty acids and lysophospholipids.	Glycerophospholipids	127-147	phospholipase A2 group IB	Homo sapiens	0-16
9282910-1	1997	Phospholipase A2 (PLA2) is the name for the class of lipolytic enzymes that hydrolyze the acyl group from the sn-2 position of glycerophospholipids, generating free fatty acids and lysophospholipids.	Glycerophospholipids	127-147	phospholipase A2 group IB	Homo sapiens	18-22
9282910-8	1997	However, under pathological situations, increased PLA2 activity may result in the loss of essential membrane glycerophospholipids, resulting in altered membrane permeability, ion homeostasis, increased free fatty acid release, and the accumulation of lipid peroxides.	Glycerophospholipids	109-129	phospholipase A2 group IB	Homo sapiens	50-54
8660688-6	1996	Upon gel filtration the activity that eluted from the anion-exchange column in the salt gradient behaved as a high molecular mass PLA2, exhibited a preference for arachidonic acid at the sn-2 position of glycerophospholipids, and was already optimally active at submillimolar Ca2+ concentrations.	Glycerophospholipids	204-224	phospholipase A2 group IB	Rattus norvegicus	130-134
8934451-3	1996	Sterols structurally related to cholesterol and some steryl esters inhibited the activity of L. giganteum phospholipase A2 (PLA2), an enzyme that hydrolyzes fatty acids from the sn-2 position of glycerophospholipids.	Glycerophospholipids	195-215	phospholipase A2 group IIA	Homo sapiens	124-128
8912671-1	1996	Cytosolic phospholipase A2 (cPLA2) selectively catalyses the release of arachidonic acid from the sn-2 position of glycero-phospholipids to produce prostaglandins and leukotrienes.	Glycerophospholipids	115-136	phospholipase A2 group IVA	Rattus norvegicus	0-26
8912671-1	1996	Cytosolic phospholipase A2 (cPLA2) selectively catalyses the release of arachidonic acid from the sn-2 position of glycero-phospholipids to produce prostaglandins and leukotrienes.	Glycerophospholipids	115-136	phospholipase A2 group IVA	Rattus norvegicus	28-33
8863185-5	1996	In many cell types, cPLA2s which are reactive towards antibodies raised against the type IV cPLA2 have been shown to hydrolyse AA from membrane glycerophospholipids.	Glycerophospholipids	144-164	phospholipase A2 group IVA	Rattus norvegicus	20-25
8863185-5	1996	In many cell types, cPLA2s which are reactive towards antibodies raised against the type IV cPLA2 have been shown to hydrolyse AA from membrane glycerophospholipids.	Glycerophospholipids	144-164	phospholipase A2 group IVA	Rattus norvegicus	92-97
8810047-1	1996	Plasmalogens are glycerophospholipids characterized by an alk-1"-enylether bond in position sn-1 and an acyl bond in position sn-2.	Glycerophospholipids	17-37	secretory leukocyte peptidase inhibitor	Homo sapiens	58-63
9157179-9	1997	The release of this extracellularly-active PLA2 isozyme may contribute to gestational and labour-associated increases in glycerophospholipid metabolism and prostaglandin formation.	Glycerophospholipids	121-140	phospholipase A2 group IB	Homo sapiens	43-47
8875957-11	1996	IL-1beta increased significantly the esterification of 13-HODE in all glycerophospholipids, the major increase being observed in phosphatidylinositol.	Glycerophospholipids	70-90	interleukin 1 beta	Homo sapiens	0-8
8828503-10	1996	Examination of structurally related glycerophospholipid species revealed the specificity of the LPC stimulation of IL-6 release.	Glycerophospholipids	36-55	interleukin 6	Rattus norvegicus	115-119
8869442-1	1996	Group II phospholipase A2 (membrane-associated phospholipase A2, M-PLA2) hydrolyses the 2-acyl position of a glycerophospholipid.	Glycerophospholipids	109-128	phospholipase A2 group IIA	Homo sapiens	67-71
8872534-1	1996	Phospholipases A2 (PLA2s) catalyze the hydrolysis of glycerophospholipids at the sn-2 position, and their inhibition is considered a rational approach for the prevention and treatment of inflammation.	Glycerophospholipids	53-73	phospholipase A2 group IIA	Homo sapiens	19-24
7722506-1	1995	Phospholipases A2 (PLA2) are a family of enzymes that catalyze the removal of fatty acid residues from phosphoglycerides.	Glycerophospholipids	103-120	phospholipase A2 group IIA	Homo sapiens	19-23
8743149-7	1995	With the identification of secretory PLA2 isozymes in human gestational tissues, a new pathway for materno-fetal and/or intrauterine communication has been established--a pathway in which secretory PLA2 isozymes released by intrauterine tissues act in an autocrine, paracrine or even endocrine fashion to affect glycerophospholipid metabolism, cell membrane fluidity and the generation of biological mediators.	Glycerophospholipids	312-331	phospholipase A2 group IB	Homo sapiens	37-41
7697937-1	1995	PAF represents a new family of glycerophospholipids and possesses multiple biological activities including platelet aggregation.	Glycerophospholipids	31-51	PCNA clamp associated factor	Homo sapiens	0-3
8743149-7	1995	With the identification of secretory PLA2 isozymes in human gestational tissues, a new pathway for materno-fetal and/or intrauterine communication has been established--a pathway in which secretory PLA2 isozymes released by intrauterine tissues act in an autocrine, paracrine or even endocrine fashion to affect glycerophospholipid metabolism, cell membrane fluidity and the generation of biological mediators.	Glycerophospholipids	312-331	phospholipase A2 group IB	Homo sapiens	198-202
8198986-1	1994	Membrane-associated phospholipase A2 (M-PLA2) is an enzyme that hydrolyses the sn-2 fatty acyl ester bond of phosphoglycerides.	Glycerophospholipids	109-126	phospholipase A2 group IIA	Homo sapiens	40-44
7949145-9	1994	Collectively, these data show that IL-8 stimulates the metabolism of choline-containing phosphoglycerides in human PMN and support a role for PA in the signaling mechanisms used by IL-8 to stimulate PMN function.	Glycerophospholipids	88-105	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
8072044-3	1994	However, the accuracy in measuring PCOOH levels, particularly in blood samples, is still in question since PCOOH may be rapidly eliminated by phospholipase A2 enzymes, which are widespread, easily activated, and have a preference for oxidized glycerophospholipids.	Glycerophospholipids	243-263	phospholipase A2 group IB	Rattus norvegicus	142-158
8396134-11	1993	Thus, LCAT is active on low density lipoprotein but mostly idling as deacylating and reacylating glycerophospholipids.	Glycerophospholipids	97-117	lecithin-cholesterol acyltransferase	Homo sapiens	6-10
8203749-1	1994	We have developed an assay for studying myocardial phospholipase A2 activity by measuring accumulation of lysophospholipids resulting from hydrolysis of the endogenous choline glycerophospholipid pool.	Glycerophospholipids	176-195	phospholipase A2	Oryctolagus cuniculus	51-67
8203755-0	1994	Quantitation of the diacyl, alkylacyl, and alk-1-enylacyl subclasses of choline glycerophospholipids by chemical dephosphorylation and benzoylation.	Glycerophospholipids	80-100	secretory leukocyte peptidase inhibitor	Homo sapiens	43-48
8177371-7	1994	Moreover, a change in PLA2 activity would result in altered metabolism of specific phosphoglycerides and turnover of fatty acids at the sn-2 position in cerebral microvessels.	Glycerophospholipids	83-100	phospholipase A2, group V	Mus musculus	22-26
8372097-2	1993	As expected, n-3 and n-6 fatty acids competed for incorporation into tissue glycerophospholipids in both dams and their suckling pups.	Glycerophospholipids	76-96	notch 3	Mus musculus	13-16
1363632-1	1992	Platelet-activating factor (PAF) is a phosphoglyceride secreted by a variety of cells and has been implicated in endotoxin toxicities.	Glycerophospholipids	38-54	patchy fur	Mus musculus	0-26
8262901-4	1993	The result suggests the importance of Ca2+ in the selective recognition and catalytic function of PLA2 toward the 2-positioned fatty acid ester of phosphoglyceride substrates.	Glycerophospholipids	147-163	LOC104974671	Bos taurus	98-102
8392098-11	1993	Phospholipase A2-like activity was assayed in the whole cell by measuring the mobilization of phospholipase A2 products, PAF, lyso PAF, and arachidonic acid, from cellular phosphoglycerides.	Glycerophospholipids	172-189	phospholipase A2 group IB	Homo sapiens	0-16
8392098-11	1993	Phospholipase A2-like activity was assayed in the whole cell by measuring the mobilization of phospholipase A2 products, PAF, lyso PAF, and arachidonic acid, from cellular phosphoglycerides.	Glycerophospholipids	172-189	phospholipase A2 group IB	Homo sapiens	94-110
8392098-11	1993	Phospholipase A2-like activity was assayed in the whole cell by measuring the mobilization of phospholipase A2 products, PAF, lyso PAF, and arachidonic acid, from cellular phosphoglycerides.	Glycerophospholipids	172-189	PCNA clamp associated factor	Homo sapiens	121-124
8485868-3	1993	Independent of the type of disease, all sera with highly increased PLA activities (40-200 U/L) showed nearly pure PLA2 characteristics without any preference among oleic, linoleic, and linolenic acid in the sn-2 position of the glycerophospholipid substrate.	Glycerophospholipids	228-247	phospholipase A and acyltransferase 1	Homo sapiens	67-70
1363632-1	1992	Platelet-activating factor (PAF) is a phosphoglyceride secreted by a variety of cells and has been implicated in endotoxin toxicities.	Glycerophospholipids	38-54	patchy fur	Mus musculus	28-31
1309300-6	1992	We demonstrate for the first time that a number of plasma membrane glycerophospholipids effectively stimulate the ATPase, including PIP, PIP2, and cardiolipin.	Glycerophospholipids	67-87	oleate-activated transcription factor PIP2	Saccharomyces cerevisiae S288C	137-141
1504447-1	1992	Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly.	Glycerophospholipids	45-61	PCNA clamp associated factor	Homo sapiens	0-26
1504447-1	1992	Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly.	Glycerophospholipids	45-61	PCNA clamp associated factor	Homo sapiens	28-31
1651967-3	1991	SP-A synthesis and gene expression are initiated in fetal lung tissue in concert with the developmental induction of surfactant glycerophospholipid synthesis.	Glycerophospholipids	128-147	surfactant protein A1	Homo sapiens	0-4
1918029-1	1991	Phospholipase A2 (PLA2), EC 3.1.1.4, which catalyzes the release of free fatty acids from the sn-2 position of glycerophospholipids, has been extensively studied from the viewpoint of eicosanoid production (Arita, H., Nakano, T., and Hanasaki, K. (1989) Prog.	Glycerophospholipids	111-131	phospholipase A2, group IB, pancreas	Mus musculus	0-16
1918029-1	1991	Phospholipase A2 (PLA2), EC 3.1.1.4, which catalyzes the release of free fatty acids from the sn-2 position of glycerophospholipids, has been extensively studied from the viewpoint of eicosanoid production (Arita, H., Nakano, T., and Hanasaki, K. (1989) Prog.	Glycerophospholipids	111-131	phospholipase A2, group IB, pancreas	Mus musculus	18-22
1762050-1	1991	Phospholipase A2 hydrolyzes the ester linkage at sn-2 of glycerophospholipids and is thought to function as a key enzyme in generation of variety of bioactive mediators, such as prostaglandins and platelet-activating factor.	Glycerophospholipids	57-77	phospholipase A2 group IB	Homo sapiens	0-16
1647275-1	1991	Platelet-activating factor (PAF) is a glycerophospholipid known for its unusual potent vasoactive and proinflammatory activities.	Glycerophospholipids	38-57	PCNA clamp associated factor	Rattus norvegicus	0-26
1647275-1	1991	Platelet-activating factor (PAF) is a glycerophospholipid known for its unusual potent vasoactive and proinflammatory activities.	Glycerophospholipids	38-57	PCNA clamp associated factor	Rattus norvegicus	28-31
2042967-1	1991	The synthesis of surfactant glycerophospholipids and proteins is under multifactorial control and is regulated by a number of hormones and factors, including glucocorticoids, prolactin, insulin, growth factors, estrogens, androgens, thyroid hormones and catecholamines acting through beta-adrenergic receptors, and cAMP.	Glycerophospholipids	28-48	insulin	Homo sapiens	186-193
2224852-7	1990	Furthermore, among the AML patients both the percentage of the choline-containing phosphoglyceride fraction (PC) which is alkyl linked and the nmoles alkyl-PC/10(6) cells differ significantly by FAB subtype.	Glycerophospholipids	82-98	FA complementation group B	Homo sapiens	195-198
2123404-3	1990	These differently located phospholipase A2 activities resulted in activation upon calcium ionophore A23187-cell treatment, but the phospholipase A2 activity found in the unidentified region showed the highest degree of activation after cell treatment with A23187 and hydrolyzed preferentially ethanolamine-containing glycerophospholipids.	Glycerophospholipids	317-337	phospholipase A2 group IB	Homo sapiens	131-147
2123404-5	1990	Choline- and ethanolamine-containing glycerophospholipids showed a broad distribution throughout the gradient, with preponderance in the denser part of the gradient, where the intracellular organelle phospholipase A2 activities were located.	Glycerophospholipids	37-57	phospholipase A2 group IB	Homo sapiens	200-216
2123404-3	1990	These differently located phospholipase A2 activities resulted in activation upon calcium ionophore A23187-cell treatment, but the phospholipase A2 activity found in the unidentified region showed the highest degree of activation after cell treatment with A23187 and hydrolyzed preferentially ethanolamine-containing glycerophospholipids.	Glycerophospholipids	317-337	phospholipase A2 group IB	Homo sapiens	26-42
2123404-6	1990	Interestingly, ethanolamine-containing glycerophospholipids were shown to be enriched in fractions containing the phospholipase A2 which hydrolyzes preferentially this phospholipid class.	Glycerophospholipids	39-59	phospholipase A2 group IB	Homo sapiens	114-130
23214144-1	2012	Phospholipase A2 (EC 3.1.1.4, PLA2) belongs to the group of enzymes that catalyze the hydrolysis of the ester bond at position sn-2 of glycerophospholipids and hence generate free fatty acids including arachidonic acid.	Glycerophospholipids	135-155	phospholipase A2 group IB	Homo sapiens	0-16
1976627-3	1990	Phospholipase A2 (PLA2) is a key enzyme in the regulation of prostaglandin and leukotriene biosynthetic pathways, which catalyzes the release of free fatty acids from the sn-2 position of membrane glycerophospholipids.	Glycerophospholipids	197-217	phospholipase A2 group IB	Homo sapiens	0-16
1976627-3	1990	Phospholipase A2 (PLA2) is a key enzyme in the regulation of prostaglandin and leukotriene biosynthetic pathways, which catalyzes the release of free fatty acids from the sn-2 position of membrane glycerophospholipids.	Glycerophospholipids	197-217	phospholipase A2 group IB	Homo sapiens	18-22
2248600-5	1990	Surfactant glycerophospholipid synthesis in fetal lung tissue is regulated by a number of hormones and factors, including glucocorticoids, prolactin, insulin, oestrogens, androgens, thyroid hormones, and catecholamines acting through cyclic AMP.	Glycerophospholipids	11-30	insulin	Homo sapiens	150-157
25313821-2	2014	However, studies using cPLA2alpha-deficient mice have indicated that other PLA2(s) may also be involved in the hydrolysis of platelet glycerophospholipids.	Glycerophospholipids	134-154	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	23-33
25313821-2	2014	However, studies using cPLA2alpha-deficient mice have indicated that other PLA2(s) may also be involved in the hydrolysis of platelet glycerophospholipids.	Glycerophospholipids	134-154	phospholipase A2, group V	Mus musculus	24-28
2403352-4	1990	It was also observed that muCANP binds to Triton X-100-treated membranes, in which most of the integral proteins and glycerophospholipids are removed while the lining proteins remain intact.	Glycerophospholipids	117-137	calpain 1	Homo sapiens	26-32
2075252-2	1990	The first step in prostaglandin synthesis is the liberation of arachidonic acid from glycerophospholipids by phospholipase A2.	Glycerophospholipids	85-105	phospholipase A2 group IB	Homo sapiens	109-125
23214144-1	2012	Phospholipase A2 (EC 3.1.1.4, PLA2) belongs to the group of enzymes that catalyze the hydrolysis of the ester bond at position sn-2 of glycerophospholipids and hence generate free fatty acids including arachidonic acid.	Glycerophospholipids	135-155	phospholipase A2 group IIA	Homo sapiens	30-34
34773816-6	2022	Of note, such a phenotype suggests the disruption of the membrane of skeletal muscle cells and red blood cells mediated by the phospholipase A1 (PLA1), PLA2, and mastoparan in the wasp venom, via the disruption of membrane glycerophospholipids.	Glycerophospholipids	223-243	lipase H	Homo sapiens	127-143
34848268-8	2022	Oxidative stress and inflammation caused the remodeling of glycerophospholipid (phosphatidylcholine (PC) and phosphatidylethanolamine (PE)), with increased incorporation of omega-3 PUFA and a decreased incorporation of omega-6 PUFA.	Glycerophospholipids	59-78	pumilio RNA-binding family member 3	Danio rerio	181-185
34773816-6	2022	Of note, such a phenotype suggests the disruption of the membrane of skeletal muscle cells and red blood cells mediated by the phospholipase A1 (PLA1), PLA2, and mastoparan in the wasp venom, via the disruption of membrane glycerophospholipids.	Glycerophospholipids	223-243	lipase H	Homo sapiens	145-149
34773816-6	2022	Of note, such a phenotype suggests the disruption of the membrane of skeletal muscle cells and red blood cells mediated by the phospholipase A1 (PLA1), PLA2, and mastoparan in the wasp venom, via the disruption of membrane glycerophospholipids.	Glycerophospholipids	223-243	phospholipase A2 group IB	Homo sapiens	152-156
34734730-4	2022	Significant differences in the levels of about 70% of the gut metabolites determined, including fatty acyls, glycerolipids, glycerophospholipids, and steroids, were found in Abx-Se compared to Abx, and only 30% were different between Abx-Se and C, suggesting an important effect of Se-supplementation on Abx mice metabolism.	Glycerophospholipids	124-144	glucuronidase, beta	Mus musculus	58-61
34634490-2	2022	Phospholipase A2 (PLA2) enzymes constitute a superfamily of enzymes which play a critical role in metabolism and signal transduction by hydrolyzing the sn-2 acyl chains of glycerophospholipids.	Glycerophospholipids	172-192	phospholipase A2 group IB	Homo sapiens	0-16
34634490-2	2022	Phospholipase A2 (PLA2) enzymes constitute a superfamily of enzymes which play a critical role in metabolism and signal transduction by hydrolyzing the sn-2 acyl chains of glycerophospholipids.	Glycerophospholipids	172-192	phospholipase A2 group IB	Homo sapiens	18-22
34549263-13	2021	Glycerophospholipid (GPL) metabolism is likely associated with GC, of which AGPAT9 and ETNPPL showed lower expressed in GC tissues.	Glycerophospholipids	0-19	glycerol-3-phosphate acyltransferase 3	Homo sapiens	76-82
34301294-10	2021	The results of the metabolomics analysis showed that the glycerophospholipid metabolism pathway was closely related to calcium supplementation, and more DG (44:6 n3), LysoPC (22:2) and PE (P-34:3) and less Cer (d43:0) and PE-NMe2 (46:3) were produced.	Glycerophospholipids	57-76	NME/NM23 nucleoside diphosphate kinase 2	Rattus norvegicus	225-229
34478587-1	2021	Group IIA secreted phospholipase A2 (PLA2G2A) hydrolyzes glycerophospholipids at the sn-2 position resulting in the release of fatty acids and lysophospholipids.	Glycerophospholipids	57-77	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	37-44
34365732-10	2021	CONCLUSIONS: This study revealed that phytosterols, COPs and POPs differently changed the composition and metabolism of glycerophospholipids, sphingolipids and glycerolipids in liver of ApoE-/- mice.	Glycerophospholipids	120-140	apolipoprotein E	Mus musculus	186-190
34512869-11	2021	PKLR also improved prognosis after LT, possibly via its impact on the increased genesis of beneficial glycerophospholipids.	Glycerophospholipids	102-122	pyruvate kinase L/R	Homo sapiens	0-4
34478892-4	2021	Herein, we review the existing literature about the implications of phospholipases 2 (PLA2s), a large family of enzymes that catalyze the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, in ARDS-related pathology.	Glycerophospholipids	188-208	phospholipase A2 group IIA	Homo sapiens	86-91
34345670-1	2021	Phosphatidic acids (PAs) are glycerophospholipids that regulate key cell signaling pathways governing cell growth and proliferation, including the mTOR and Hippo pathways.	Glycerophospholipids	29-49	mechanistic target of rapamycin kinase	Homo sapiens	147-151
34549263-13	2021	Glycerophospholipid (GPL) metabolism is likely associated with GC, of which AGPAT9 and ETNPPL showed lower expressed in GC tissues.	Glycerophospholipids	0-19	ethanolamine-phosphate phospho-lyase	Homo sapiens	87-93
34097986-1	2021	Secreted phospholipases A2 (sPLA2s) form a widespread group of structurally-related enzymes that catalyse the hydrolysis of the sn-2 ester bond of glycerophospholipids to produce free fatty acids and lysophospholipids.	Glycerophospholipids	147-167	phospholipase A2 group IID	Homo sapiens	28-34
34458952-7	2021	By using whole transcriptome sequencing, we found that CLA significantly downregulated the mRNA expression of CEPT1 and CHPT1, two key enzymes involved in the synthesis of glycerophospholipids, supporting the findings from the lipidomic profiling.	Glycerophospholipids	172-192	choline/ethanolaminephosphotransferase 1	Mus musculus	110-115
34458952-7	2021	By using whole transcriptome sequencing, we found that CLA significantly downregulated the mRNA expression of CEPT1 and CHPT1, two key enzymes involved in the synthesis of glycerophospholipids, supporting the findings from the lipidomic profiling.	Glycerophospholipids	172-192	choline phosphotransferase 1	Mus musculus	120-125
34458952-14	2021	Clarithromycin application remarkably attenuated CEPT1 and CHPT1 gene expression, which participate in the last step in the synthesis of glycerophospholipids; 4.	Glycerophospholipids	137-157	choline/ethanolaminephosphotransferase 1	Mus musculus	49-54
34458952-14	2021	Clarithromycin application remarkably attenuated CEPT1 and CHPT1 gene expression, which participate in the last step in the synthesis of glycerophospholipids; 4.	Glycerophospholipids	137-157	choline phosphotransferase 1	Mus musculus	59-64
34272396-4	2021	Further studies identify sterol regulatory element binding transcription factor 1 (SREBF1) as a central mediator linking TP63 with fatty-acid metabolism, which regulates the biosynthesis of fatty-acids, sphingolipids (SL), and glycerophospholipids (GPL), as revealed by liquid chromatography tandem mass spectrometry (LC-MS/MS)-based lipidomics.	Glycerophospholipids	227-247	sterol regulatory element binding transcription factor 1	Homo sapiens	25-81
34272396-4	2021	Further studies identify sterol regulatory element binding transcription factor 1 (SREBF1) as a central mediator linking TP63 with fatty-acid metabolism, which regulates the biosynthesis of fatty-acids, sphingolipids (SL), and glycerophospholipids (GPL), as revealed by liquid chromatography tandem mass spectrometry (LC-MS/MS)-based lipidomics.	Glycerophospholipids	227-247	sterol regulatory element binding transcription factor 1	Homo sapiens	83-89
34272396-4	2021	Further studies identify sterol regulatory element binding transcription factor 1 (SREBF1) as a central mediator linking TP63 with fatty-acid metabolism, which regulates the biosynthesis of fatty-acids, sphingolipids (SL), and glycerophospholipids (GPL), as revealed by liquid chromatography tandem mass spectrometry (LC-MS/MS)-based lipidomics.	Glycerophospholipids	227-247	tumor protein p63	Homo sapiens	121-125
34474084-1	2021	Human phospholipase A2"s (PLA2) constitute a superfamily of enzymes that hydrolyze the sn-2 acyl-chain of glycerophospholipids, producing lysophospholipids and free fatty acids.	Glycerophospholipids	106-126	phospholipase A2 group VI	Homo sapiens	6-24
34089703-1	2021	Phospholipase A1 (PLA1) hydrolyzes the fatty acids of glycerophospholipids, which are structural components of the cellular membrane.	Glycerophospholipids	54-74	lipase H	Homo sapiens	0-16
34089703-1	2021	Phospholipase A1 (PLA1) hydrolyzes the fatty acids of glycerophospholipids, which are structural components of the cellular membrane.	Glycerophospholipids	54-74	lipase H	Homo sapiens	18-22
34382031-0	2021	Genomic-Metabolomic Associations Support the Role of LIPC and Glycerophospholipids in Age-Related Macular Degeneration.	Glycerophospholipids	62-82	renin binding protein	Homo sapiens	86-89
34382031-15	2021	Polymorphisms in the LIPC gene were associated with phosphatidylethanolamine metabolites, which are glycerophospholipids, and polymorphisms in the ASPM gene with branched-chain amino acids.	Glycerophospholipids	100-120	lipase C, hepatic type	Homo sapiens	21-25
34602568-2	2021	Recent knock-out mouse studies revealed that among ACSL isoenzymes, ACSL6 plays an important role in the maintenance of docosahexaenoic acid (DHA)-containing glycerophospholipids.	Glycerophospholipids	158-178	acyl-CoA synthetase long-chain family member 6	Mus musculus	68-73
34143495-7	2021	Relaxin-2 significantly modified the hepatic levels of 19 glycerophospholipids, 2 saturated (SFA) and 1 monounsaturated (MUFA) fatty acids (FA), 3 diglycerides, 1 sphingomyelin, 2 aminoacids, 5 nucleosides, 2 nucleotides, 1 carboxylic acid, 1 redox electron carrier, and 1 vitamin.	Glycerophospholipids	58-78	relaxin 2	Homo sapiens	0-9
34142819-8	2021	Glycerophospholipid (GP) metabolism and related genes were significantly changed in CRTC3-overexpressing IM adipocytes.	Glycerophospholipids	0-19	CREB regulated transcription coactivator 3	Homo sapiens	84-89
34142819-8	2021	Glycerophospholipid (GP) metabolism and related genes were significantly changed in CRTC3-overexpressing IM adipocytes.	Glycerophospholipids	21-23	CREB regulated transcription coactivator 3	Homo sapiens	84-89
34474084-1	2021	Human phospholipase A2"s (PLA2) constitute a superfamily of enzymes that hydrolyze the sn-2 acyl-chain of glycerophospholipids, producing lysophospholipids and free fatty acids.	Glycerophospholipids	106-126	phospholipase A2 group VI	Homo sapiens	26-30
35564009-4	2022	The results showed that the quantities of glycerolipids, sphingolipids, fatty acyls and glycerophospholipids were significantly changed, particularly, the molecular diacylglycerol in glycerolipids, long-chain unsaturated fatty acids, and ceramide non-hydroxy fatty acid-sphingosine in sphingolipids were remarkably increased in the MSTN+/- group.	Glycerophospholipids	88-108	myostatin	Sus scrofa	332-336
35474485-7	2022	Furthermore, pre-treatment of H121 and L13 pectins could improve the serum glycerophospholipids such as phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Glycerophospholipids	75-95	skull morphology 20	Mus musculus	39-42
35474485-13	2022	Glycerophospholipid metabolism was significantly enriched by H121 and L13 pectins.	Glycerophospholipids	0-19	skull morphology 20	Mus musculus	70-73
35584785-7	2022	Importantly, hippocampal LPCAT1 overexpression restored the dysregulated glycerophospholipid (GP) metabolism and alleviated the learning and memory deficits caused by sevoflurane.	Glycerophospholipids	94-96	lysophosphatidylcholine acyltransferase 1	Rattus norvegicus	25-31
35527485-8	2022	In NCI N87R cells, RUNX3 knockdown resulted in noticeable alterations in 8 pathways involving glutamine metabolism, glycolysis, glycerophospholipid, nicotinate-nicotinamide and glutathione metabolism, causing also significant reduction of intracellular GSH/GSSG and NADPH/NADP ratios (P < 0.01).	Glycerophospholipids	128-147	RUNX family transcription factor 3	Homo sapiens	19-24
35469367-12	2022	These results suggested that the down-regulated glycerophospholipids in hippocampus, especially cardiolipin, might participate in the pathophysiology of PSD.	Glycerophospholipids	48-68	pleckstrin and Sec7 domain containing	Rattus norvegicus	153-156
35219101-0	2022	Glycerophospholipid metabolism is involved in rheumatoid arthritis pathogenesis by regulating the IL-6/JAK signaling pathway.	Glycerophospholipids	0-19	interleukin 6	Homo sapiens	98-102
35219101-0	2022	Glycerophospholipid metabolism is involved in rheumatoid arthritis pathogenesis by regulating the IL-6/JAK signaling pathway.	Glycerophospholipids	0-19	Janus kinase 2	Homo sapiens	103-106
35458682-1	2022	Phospholipase A1 (PLA1) is an enzyme that cleaves an ester bond at the sn-1 position of glycerophospholipids, producing a free fatty acid and a lysophospholipid.	Glycerophospholipids	88-108	lipase H	Homo sapiens	0-16
35416773-3	2022	ATP8B1 forms a binary complex with CDC50A and displays a broad specificity to glycerophospholipids, but regulatory mechanisms are unknown.	Glycerophospholipids	78-98	ATPase phospholipid transporting 8B1	Homo sapiens	0-6
35416773-3	2022	ATP8B1 forms a binary complex with CDC50A and displays a broad specificity to glycerophospholipids, but regulatory mechanisms are unknown.	Glycerophospholipids	78-98	transmembrane protein 30A	Homo sapiens	35-41
35458682-1	2022	Phospholipase A1 (PLA1) is an enzyme that cleaves an ester bond at the sn-1 position of glycerophospholipids, producing a free fatty acid and a lysophospholipid.	Glycerophospholipids	88-108	lipase H	Homo sapiens	18-22
35096834-4	2021	UCP1 KI changed the contents of glycerophospholipids and acyl carnitines of skeletal muscles.	Glycerophospholipids	32-52	LOW QUALITY PROTEIN: mitochondrial brown fat uncoupling protein 1	Sus scrofa	0-4
35384404-11	2022	Lipidomic analysis further identified markedly reduced glycerolipids, glycerophospholipids, NEFA and acylcarnitines in Bscl2cKO hearts, which were partially normalised by TMZ or HFD.	Glycerophospholipids	70-90	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	Mus musculus	119-124
35359829-8	2022	Moreover, the integrative analysis of the transcriptomics and metabolomics data indicated that TA inhibited the glycerophospholipid metabolism pathway by inhibiting the expression of LPCAT4, PTDSS2, PLA2G2A and CEPT1.	Glycerophospholipids	112-131	lysophosphatidylcholine acyltransferase 4	Rattus norvegicus	183-189
35359829-8	2022	Moreover, the integrative analysis of the transcriptomics and metabolomics data indicated that TA inhibited the glycerophospholipid metabolism pathway by inhibiting the expression of LPCAT4, PTDSS2, PLA2G2A and CEPT1.	Glycerophospholipids	112-131	phosphatidylserine synthase 2	Rattus norvegicus	191-197
35359829-8	2022	Moreover, the integrative analysis of the transcriptomics and metabolomics data indicated that TA inhibited the glycerophospholipid metabolism pathway by inhibiting the expression of LPCAT4, PTDSS2, PLA2G2A and CEPT1.	Glycerophospholipids	112-131	phospholipase A2 group IIA	Rattus norvegicus	199-206
35359829-8	2022	Moreover, the integrative analysis of the transcriptomics and metabolomics data indicated that TA inhibited the glycerophospholipid metabolism pathway by inhibiting the expression of LPCAT4, PTDSS2, PLA2G2A and CEPT1.	Glycerophospholipids	112-131	choline/ethanolamine phosphotransferase 1	Rattus norvegicus	211-216
34998158-10	2022	Taken together, these findings indicate that the CBL/LSD1/CXCL8 axis is a novel mechanistic connection linking between methionine metabolism, histone methylation and glycerophospholipid reprogramming in the tumor microenvironment.	Glycerophospholipids	166-185	Cbl proto-oncogene	Homo sapiens	49-52
34998158-10	2022	Taken together, these findings indicate that the CBL/LSD1/CXCL8 axis is a novel mechanistic connection linking between methionine metabolism, histone methylation and glycerophospholipid reprogramming in the tumor microenvironment.	Glycerophospholipids	166-185	lysine demethylase 1A	Homo sapiens	53-57
34998158-10	2022	Taken together, these findings indicate that the CBL/LSD1/CXCL8 axis is a novel mechanistic connection linking between methionine metabolism, histone methylation and glycerophospholipid reprogramming in the tumor microenvironment.	Glycerophospholipids	166-185	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
35204081-6	2022	Employing detailed lipidomic analysis, we also demonstrate a typical cleavage pattern for TBHP-activated iPLA2gamma, reflecting cleavage of glycerophospholipids from both sn-1 and sn-2 positions releasing saturated FAs, monoenoic FAs, and predominant polyunsaturated FAs.	Glycerophospholipids	140-160	patatin-like phospholipase domain containing 8	Mus musculus	105-115
35293916-6	2022	We compared relative lipid abundances throughout development, from embryonic day 12.5 to postnatal day 0 and determined differentially expressed brain lipids between wild-type and Dhcr7-KO mice at specific developmental time points, revealing lipid metabolic pathways that are affected in SLOS beyond the cholesterol biosynthesis pathway, such as glycerolipid, glycerophospholipid, and sphingolipid metabolism.	Glycerophospholipids	361-380	7-dehydrocholesterol reductase	Mus musculus	180-185
35235794-4	2022	Using lipidomic, transcriptomic, and genetic screens, we determine that peroxisomes contribute to the cell membrane glycerophospholipid composition necessary to induce Rho1-dependent signals, which drive cytoskeletal remodeling during macrophage activation.	Glycerophospholipids	116-135	Rho1	Drosophila melanogaster	168-172
35233071-2	2022	TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT).	Glycerophospholipids	240-257	glycerol-3-phosphate acyltransferase, chloroplastic	Brassica napus	82-118
35233071-2	2022	TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT).	Glycerophospholipids	240-257	glycerol-3-phosphate acyltransferase, chloroplastic	Brassica napus	120-124
35131480-4	2022	In particular, characterization of the lipidome of human HCCs has accelerated, and together with biochemical analyses, are revealing recurrent patterns of alterations in glycerophospholipid, sphingolipid, cholesterol and bile acid metabolism.	Glycerophospholipids	170-189	holocytochrome c synthase	Homo sapiens	57-61
35053343-9	2022	Lipidomic analysis evidenced that Ac9-12 and WKYMV altered the intracellular lipid profile of LPS-stimulated macrophages, revealing an increased concentration of several glycerophospholipids, suggesting regulation of inflammatory pathways triggered by LPS.	Glycerophospholipids	170-190	adenylate cyclase 9	Mus musculus	34-37
2493151-6	1989	We conclude that the transduction signal of GH action in c-fos mRNA induction is the formation of diacylglycerol and that the mechanism whereby GH can activate protein kinase C is associated with a phospholipase C-mediated hydrolysis of glycerophospholipids other than inositol phospholipids.	Glycerophospholipids	237-257	growth hormone	Mus musculus	44-46
35316158-9	2022	Its obliteration correlated with improved weight loss and insulin resistance, possibly through decreases in glycerophospholipids.	Glycerophospholipids	108-128	insulin	Homo sapiens	58-65
2675833-3	1989	Phospholipase D was also activated by ionomycin or sodium fluoride; however, this was accompanied by parallel increases in diglyceride, monoacylglycerol and arachidonic acid in the absence of phosphorylcholine generation, suggesting that these agents also activated a phospholipase C-diglyceride lipase pathway acting on non-choline-containing phosphoglycerides (presumably phosphoinositides).	Glycerophospholipids	344-361	lipase G, endothelial type	Rattus norvegicus	7-13
2794783-0	1989	A novel method for the analysis of platelet-activating factor: direct derivatization of glycerophospholipids.	Glycerophospholipids	88-108	PCNA clamp associated factor	Homo sapiens	35-61
2911004-2	1989	The technique consists of adsorption of bee venom phospholipase A2 to colloidal gold particles (PLA2-gold complex) and subsequent application of this complex for localization of the enzyme substrate, i.e., glycerophospholipids.	Glycerophospholipids	206-226	phospholipase A2 group IB	Rattus norvegicus	50-66
2493151-6	1989	We conclude that the transduction signal of GH action in c-fos mRNA induction is the formation of diacylglycerol and that the mechanism whereby GH can activate protein kinase C is associated with a phospholipase C-mediated hydrolysis of glycerophospholipids other than inositol phospholipids.	Glycerophospholipids	237-257	growth hormone	Mus musculus	144-146
3192002-3	1988	Treatment with phospholipase A2 degraded all glycerophospholipids in the outer monolayer.	Glycerophospholipids	45-65	phospholipase A2 group IB	Rattus norvegicus	15-31
3117829-6	1987	The finding of decreased free and phospholipase A2-releasable arachidonic acid of the total lipid extract of the amnion of women with dysfunctional labor could suggest further metabolic exhaustion of the substrate or failure of liberation of this fatty acid from glycerophospholipids by enzymes other than phospholipase A2, such as phospholipase C or diacyl and monoacylglycerolipases.	Glycerophospholipids	263-283	phospholipase A2 group IB	Homo sapiens	34-50
2849074-2	1988	In the presence of phospholipase A2 or phospholipase C, which almost completely hydrolyzed microsomal phosphoglycerides, the activities of Cl-ATPase and Na,K-ATPase were decreased to 8-50% of the control, but anion-insensitive Mg-ATPase activity was not altered.	Glycerophospholipids	102-119	phospholipase A2 group IB	Rattus norvegicus	19-35
3139040-0	1988	Selective hydrolysis of ether-containing glycerophospholipids by phospholipase A2 in rabbit lung.	Glycerophospholipids	41-61	phospholipase A2	Oryctolagus cuniculus	65-81
2830903-6	1988	Experiments employing REF52 cells prelabeled with [3H]choline demonstrated that both TPA and vasopressin induce the hydrolysis of cellular choline-containing glycerophospholipids; this was measured by both a decrease in cell-associated phosphatidylcholine radioactivity and an increase in the production of water-soluble [3H]choline-containing metabolites in the culture medium.	Glycerophospholipids	158-178	arginine vasopressin	Rattus norvegicus	93-104
2830903-9	1988	These data demonstrate that tumor-promoting phorbol esters (agonists of protein kinase C), serum and vasopressin, increase the levels of cellular diacylglycerol by stimulating the hydrolysis of choline-containing glycerophospholipids.	Glycerophospholipids	213-233	arginine vasopressin	Rattus norvegicus	101-112
3213578-2	1988	Therefore, the fatty acyl (PUFA) compositions of phosphoglycerides in embryonic brains (days E-17 and E-18) of T-16 mice have been compared with those of balanced heterozygotic embryos from the same litters, in order to determine whether similar abnormalities are present as have been found in foetal DS brain (Brooksbank et al., 1985, J. Neurochem.	Glycerophospholipids	49-66	pumilio RNA binding family member 3	Homo sapiens	27-31
3213578-6	1988	The PUFA composition of the phosphoglycerides of the corresponding trisomic and balanced placentae was also determined, but no relevant differences could be discerned between the genetically different tissues.	Glycerophospholipids	28-45	pumilio RNA binding family member 3	Homo sapiens	4-8
2441978-2	1987	beta-Sympathomimetic agents, which activate adenylate cyclase and increase tissue cAMP levels, as well as cAMP analogs stimulate surfactant glycerophospholipid synthesis and secretion by fetal lung tissue.	Glycerophospholipids	140-159	cathelicidin antimicrobial peptide	Homo sapiens	106-110
2961979-6	1987	These results indicate that glycerophospholipids are required for the sarcolemmal Mg2+ ATPase activity to a greater extent in comparison to that for the Ca2+ ATPase activity and the phospholipids associated with Mg2+ ATPase are predominantly exposed at the outer surface of the membrane.	Glycerophospholipids	28-48	dynein axonemal heavy chain 8	Homo sapiens	87-93
3092867-1	1986	In stimulated neutrophils the production of eicosinoids and the lipid mediator, platelet-activating factor, is thought to be initiated by the activation of a phospholipase A2 which cleaves arachidonic acid from choline-containing glycerophospholipids.	Glycerophospholipids	230-250	phospholipase A2 group IB	Homo sapiens	158-174
3790604-0	1987	Hydrolysis of membrane-associated phosphoglycerides by mitochondrial phospholipase A2.	Glycerophospholipids	34-51	phospholipase A2 group IB	Rattus norvegicus	69-85
3081685-1	1986	In adult rats, a significant portion of brain ethanolamine glycerophospholipids are synthesized by a pathway involving phosphatidylserine decarboxylase, a mitochondrial enzyme.	Glycerophospholipids	59-79	phosphatidylserine decarboxylase	Rattus norvegicus	119-151
3081685-11	1986	Our studies in vitro and in vivo both suggest that phosphatidylserine decarboxylase plays a significant role in the synthesis of brain ethanolamine glycerophospholipids at all ages, although it is relatively more prominent early in development.	Glycerophospholipids	148-168	phosphatidylserine decarboxylase	Rattus norvegicus	51-83
6373801-12	1984	The bulk of the VLDL triacylglycerol and some VLDL phosphoglyceride is introduced early in the secretory pathway proximal, yet subsequent to apopeptide synthesis, while a significant fraction of VLDL phosphoglyceride associates with the resulting triacylglycerol-rich lipid-protein complexes just prior to their secretion as mature VLDL.	Glycerophospholipids	51-67	very low density lipoprotein receptor	Gallus gallus	16-20
6437335-0	1984	Phosphoglyceride biosynthesis by brain microsomes: centrophenoxine, SaH-42-348, and DH-990 inhibit phospholipid N-methylation.	Glycerophospholipids	0-16	acyl-CoA synthetase medium chain family member 3	Homo sapiens	68-71
3936503-3	1985	Inhibition of phospholipase A2 and C2 activity was suggested from suppression of release of [14C]-arachidonic acid from pre-labeled platelet glycerophospholipids.	Glycerophospholipids	141-161	phospholipase A2 group IB	Homo sapiens	14-30
3987344-8	1985	The low concentration of phospholipid in the lens nucleus could be due to breakdown of phosphoglycerides by PLA2 in the cortex as equatorial fiber cells shift toward the nucleus with aging.	Glycerophospholipids	87-104	phospholipase A2 group IB	Rattus norvegicus	108-112
6373801-12	1984	The bulk of the VLDL triacylglycerol and some VLDL phosphoglyceride is introduced early in the secretory pathway proximal, yet subsequent to apopeptide synthesis, while a significant fraction of VLDL phosphoglyceride associates with the resulting triacylglycerol-rich lipid-protein complexes just prior to their secretion as mature VLDL.	Glycerophospholipids	51-67	very low density lipoprotein receptor	Gallus gallus	46-50
6373801-12	1984	The bulk of the VLDL triacylglycerol and some VLDL phosphoglyceride is introduced early in the secretory pathway proximal, yet subsequent to apopeptide synthesis, while a significant fraction of VLDL phosphoglyceride associates with the resulting triacylglycerol-rich lipid-protein complexes just prior to their secretion as mature VLDL.	Glycerophospholipids	51-67	very low density lipoprotein receptor	Gallus gallus	46-50
6373801-12	1984	The bulk of the VLDL triacylglycerol and some VLDL phosphoglyceride is introduced early in the secretory pathway proximal, yet subsequent to apopeptide synthesis, while a significant fraction of VLDL phosphoglyceride associates with the resulting triacylglycerol-rich lipid-protein complexes just prior to their secretion as mature VLDL.	Glycerophospholipids	200-216	very low density lipoprotein receptor	Gallus gallus	16-20
6373801-13	1984	Within the context of current models for VLDL structure, the late assembly of phosphoglyceride into VLDL is taken to represent a surface maturation of the nascent VLDL particle.	Glycerophospholipids	78-94	very low density lipoprotein receptor	Gallus gallus	100-104
6373801-13	1984	Within the context of current models for VLDL structure, the late assembly of phosphoglyceride into VLDL is taken to represent a surface maturation of the nascent VLDL particle.	Glycerophospholipids	78-94	very low density lipoprotein receptor	Gallus gallus	100-104
6373801-12	1984	The bulk of the VLDL triacylglycerol and some VLDL phosphoglyceride is introduced early in the secretory pathway proximal, yet subsequent to apopeptide synthesis, while a significant fraction of VLDL phosphoglyceride associates with the resulting triacylglycerol-rich lipid-protein complexes just prior to their secretion as mature VLDL.	Glycerophospholipids	51-67	very low density lipoprotein receptor	Gallus gallus	46-50
6643499-0	1983	Sequential assembly of very low density lipoprotein apolipoproteins, triacylglycerol, and phosphoglycerides by the intact liver cell.	Glycerophospholipids	90-107	very low density lipoprotein receptor	Gallus gallus	23-51
6643499-8	1983	Some VLDL phosphoglyceride and the VLDL triacylglycerol are assembled with apolipoprotein early in the secretory pathway, forming a triacylglycerol-rich lipid-protein particle into which further phosphoglyceride is introduced just prior to its secretion as mature VLDL.	Glycerophospholipids	195-211	very low density lipoprotein receptor	Gallus gallus	5-9
6643499-8	1983	Some VLDL phosphoglyceride and the VLDL triacylglycerol are assembled with apolipoprotein early in the secretory pathway, forming a triacylglycerol-rich lipid-protein particle into which further phosphoglyceride is introduced just prior to its secretion as mature VLDL.	Glycerophospholipids	10-26	very low density lipoprotein receptor	Gallus gallus	5-9
6643499-8	1983	Some VLDL phosphoglyceride and the VLDL triacylglycerol are assembled with apolipoprotein early in the secretory pathway, forming a triacylglycerol-rich lipid-protein particle into which further phosphoglyceride is introduced just prior to its secretion as mature VLDL.	Glycerophospholipids	195-211	very low density lipoprotein receptor	Gallus gallus	35-39
6643499-8	1983	Some VLDL phosphoglyceride and the VLDL triacylglycerol are assembled with apolipoprotein early in the secretory pathway, forming a triacylglycerol-rich lipid-protein particle into which further phosphoglyceride is introduced just prior to its secretion as mature VLDL.	Glycerophospholipids	195-211	very low density lipoprotein receptor	Gallus gallus	35-39
7295742-4	1981	The activity of the hepatic lipase, but not the lipoprotein lipase, could be stimulated by Triton X-100 and phosphoglycerides.	Glycerophospholipids	108-125	lipase C, hepatic type	Homo sapiens	20-34
6304446-2	1983	The labeling of choline glycerophospholipid (CGP) from radioactive cytidine-5"-diphosphate choline (CDP-choline) in vitro shows a maximum at pH 8.0 (using Hepes [4-(2-hydroxyethyl)-piperazine-1-ethane-2-sulfonic acid] as a buffer) and is stimulated by Mn2+, Mg2+ and diacylglycerol.	Glycerophospholipids	24-43	cut like homeobox 1	Homo sapiens	100-103
6839505-3	1983	This report is concerned with the probing of the asymmetric transbilayer distribution of the glycerophospholipids using phospholipase A2 from bee venom.	Glycerophospholipids	93-113	phospholipase A2 group IB	Homo sapiens	120-136
24875607-2	1983	In the immature cord, diacyl-GPC is the major phosphoglyceride in both microsomal and myelin fractions.	Glycerophospholipids	46-62	glycophorin C	Rattus norvegicus	29-32
6812643-2	1982	The initial rate of filipin-unesterified cholesterol association was enhanced upon hydrolysis of the glycerophospholipids of human HDL3 by phospholipase A2.	Glycerophospholipids	101-121	HDL3	Homo sapiens	131-135
6812643-2	1982	The initial rate of filipin-unesterified cholesterol association was enhanced upon hydrolysis of the glycerophospholipids of human HDL3 by phospholipase A2.	Glycerophospholipids	101-121	phospholipase A2 group IB	Homo sapiens	139-155
7087686-3	1982	In the second series of experiments, the purified phospholipase A2 showed preferential action toward PI (100%) compared to phosphatidylcholine (PC, 62.5%), phosphatidic acid (PA, 32.6%), phosphatidylethanolamine (PE, 25.1%) and phosphatidylserine (PS, 21.5%), where each phosphoglyceride was  labeled in the 2-position with [1-14C] oleic acid.	Glycerophospholipids	271-287	LOC104974671	Bos taurus	50-66
7087686-5	1982	In the final series of experiments, the addition of the phosphoglycerides PC, PE, PS and PA in amounts of 5 or 10 microM caused either no inhibition (PE, 2%), slight inhibition (PC, 15%) or reasonably significant inhibition (PA, 20% and PS, 40%) of action of the purified phospholipase A2 on 1-acyl, 2-[1-14C]-oleoyl PI.	Glycerophospholipids	56-73	LOC104974671	Bos taurus	272-288
7464926-1	1981	The esterolytic enzyme phospholipase A2 specificially splits the 2-acyl linkage of phosphoglycerides in a calcium-dependent reaction.	Glycerophospholipids	83-100	LOC104974671	Bos taurus	23-39
454594-6	1979	From the initial velocity rate, the time required for the phosphatidylcholine pool to double was about 12 h. Agarose-linked phospholipase A2 was used to measure the relative composition of choline- and dimethylethanolamine-phosphoglycerides in the outer surface of vesicles prepared from cells with different degrees of polar head group substitution.	Glycerophospholipids	223-240	phospholipase A2 group IB	Homo sapiens	124-140
7464984-9	1980	The increased hydrolysis of polyunsaturated acyl groups in brain membrane phosphoglycerides due to the ischemic and hypoxic treatments seemed to correlate well with the implication of phospholipase A(2) involvement in eliciting the increase in free fatty acids during brain stimulation.	Glycerophospholipids	74-91	phospholipase A2 group IB	Rattus norvegicus	184-202
17941181-11	1980	Our results combined with those obtained from our previous studies of the PAF structure using specific phospholipases indicate that PAF is a glycero-phospholipid devoid of ester function at position 1.	Glycerophospholipids	141-161	PCNA clamp associated factor	Homo sapiens	132-135
87159-2	1978	In mammalian cells the catabolism of membrane phosphoglycerides proceeds probably entirely through a deacylation pathway catalysed by phospholipase A and lysophospholipase (Wise &amp; Elwyn, 1965).	Glycerophospholipids	46-63	phospholipase A and acyltransferase 1	Homo sapiens	134-171
153765-5	1979	These observations demonstrate that the activity of the ATPase is directly proportional to the ionic charge on phospholipid activators if the acyl chain composition of the phosphoglycerides is relatively constant.	Glycerophospholipids	172-189	dynein axonemal heavy chain 8	Homo sapiens	56-62
137746-6	1977	Treatment of ghosts with phospholipase A2 (from either procine pancreas of Naja naja venom), under conditions causing an essentially complete hydrolysis of the total glycerophospholipid fraction of the membrane, results in inactivation of the (Ca2+ + Mg2+)-ATPase by some 80--85%.	Glycerophospholipids	166-185	phospholipase A2 group IB	Homo sapiens	25-41
629287-2	1978	The substrate specificity of phospholipase A acitivty of fetal membranes and uterine decidua was investigated with the use of synthetic substrates, and emphasis was on the specificity of fatty acid esters in the sn-2 position of glycerophospholipids.	Glycerophospholipids	229-249	phospholipase A and acyltransferase 1	Homo sapiens	29-44
910910-7	1977	In contrast, the Vmax of [14C]choline phosphoglyceride formation from [14C]CDP-choline was increased, whereas the apparent Km for this reaction was unchanged.	Glycerophospholipids	38-54	cut-like homeobox 1	Rattus norvegicus	75-78
910910-8	1977	These results indicate that increased renal choline phosphoglyceride formation during potassium depletion can occur via the Kennedy pathway and appears to be mediated by increases in choline uptake and the rate of CDP-choline incorporation into phospholipid, the first and last steps of the pathway.	Glycerophospholipids	52-68	cut-like homeobox 1	Rattus norvegicus	214-217
5500178-0	1970	The acyl and alk-1-enyl groups of the major phosphoglycerides from ox brain myelin and mouse brain microsomal, mitochondrial and myelin fractions.	Glycerophospholipids	44-61	activin A receptor, type II-like 1	Mus musculus	13-18
1180685-0	1975	On the activity of brain phospholipase A2 towards specifically labelled glycerophospholipids during subacute sclerosing panencephalitis.	Glycerophospholipids	72-92	phospholipase A2 group IB	Rattus norvegicus	25-41
4430914-0	1974	Phospholipid metabolism in experimental allergic encephalomyelitis: activity of brain phospholipase A1 towards specifically labelled glycerophospholipids.	Glycerophospholipids	133-153	lipase H	Homo sapiens	86-102
50420-0	1975	On the effect of brain phospholipase A1 on specifically labelled glycerophospholipids in the course of subacute sclerosing panencephalitis.	Glycerophospholipids	65-85	lipase H	Homo sapiens	23-39
4345640-0	1973	Isolation and renin-inhibitory activity of phosphoglyceride from shark kidney.	Glycerophospholipids	43-59	renin	Homo sapiens	14-19
33912962-5	2022	Furthermore, we discover that the SMP domain of PDZD8 binds glycerophospholipids and ceramides both in vivo and in vitro, and that the SMP domain can transport lipids between membranes in vitro.	Glycerophospholipids	60-80	PDZ domain containing 8	Homo sapiens	48-53
33900381-3	2021	We here determined whether the levels of macrophage glycerophospholipids, sphingolipids including ceramides, triacylglycerides, and cytokine release could be altered by FATP4 inactivation.	Glycerophospholipids	52-72	solute carrier family 27 (fatty acid transporter), member 4	Mus musculus	169-174
33623047-5	2021	The lipid transfer domain of human VPS13D binds glycerophospholipids and FAs in vitro.	Glycerophospholipids	48-68	vacuolar protein sorting 13 homolog D	Homo sapiens	35-41
33955494-6	2021	Enzymatic analysis showed that NPC4 hydrolyzed GIPC and displayed a higher activity toward GIPC as a substrate than toward the common glycerophospholipid phosphatidylcholine.	Glycerophospholipids	134-153	non-specific phospholipase C4	Arabidopsis thaliana	31-35
33580989-1	2021	Phospholipase A2 (PLA2 ) is responsible for the release of fatty acids from glycerophospholipids.	Glycerophospholipids	76-96	phospholipase A2 group IB	Homo sapiens	0-16
33580989-1	2021	Phospholipase A2 (PLA2 ) is responsible for the release of fatty acids from glycerophospholipids.	Glycerophospholipids	76-96	phospholipase A2 group IB	Homo sapiens	18-22
33222147-9	2021	The following metabolic pathways were identified as being differentially active in control CA1 vs. CA2-4,DG: metabolism of taurine and hypotaurine, glycerophospholipid, and purine.	Glycerophospholipids	148-167	carbonic anhydrase 1	Homo sapiens	91-94
33222147-9	2021	The following metabolic pathways were identified as being differentially active in control CA1 vs. CA2-4,DG: metabolism of taurine and hypotaurine, glycerophospholipid, and purine.	Glycerophospholipids	148-167	carbonic anhydrase 2	Homo sapiens	99-104
33689121-7	2021	Lysophosphatidic acid (LPA) is an active glycerophospholipid mainly synthesized by the secreted enzyme autotaxin (ATX), which activates six different G protein-coupled receptors named LPA1 to LPA6 (LPARs).	Glycerophospholipids	41-60	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	103-112
33689121-7	2021	Lysophosphatidic acid (LPA) is an active glycerophospholipid mainly synthesized by the secreted enzyme autotaxin (ATX), which activates six different G protein-coupled receptors named LPA1 to LPA6 (LPARs).	Glycerophospholipids	41-60	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	114-117
33689121-7	2021	Lysophosphatidic acid (LPA) is an active glycerophospholipid mainly synthesized by the secreted enzyme autotaxin (ATX), which activates six different G protein-coupled receptors named LPA1 to LPA6 (LPARs).	Glycerophospholipids	41-60	lysophosphatidic acid receptor 1	Homo sapiens	184-188
33689121-7	2021	Lysophosphatidic acid (LPA) is an active glycerophospholipid mainly synthesized by the secreted enzyme autotaxin (ATX), which activates six different G protein-coupled receptors named LPA1 to LPA6 (LPARs).	Glycerophospholipids	41-60	lysophosphatidic acid receptor 6	Homo sapiens	192-196
33285186-10	2021	The lipidomic analysis showed that zebrafish gpbar1 activation in ZF4 cells resulted a change of glycerophospholipids, but none of bile acids nor their derivatives, which were different from mammalian GPBAR1.	Glycerophospholipids	97-117	G protein-coupled bile acid receptor 1	Danio rerio	45-51
33440601-8	2021	The lipidomics of supernatants from nigericin-stimulated WT and AnxA1-/- neutrophils showed potential lipid biomarkers of cell stress and activation, including specific sphingolipids and glycerophospholipids.	Glycerophospholipids	187-207	annexin A1	Mus musculus	64-69
33545502-5	2021	Pathway analysis revealed that the metabolism of tyrosine, glycine, taurine, fatty acid and glycerophospholipid as well as the biosynthesis of tryptophan, pantothenate and CoA were significantly dysregulated in the Ntcp KO mice, indicating that NTCP is closely involved in these metabolic pathways.	Glycerophospholipids	92-111	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	Mus musculus	215-219
33387838-8	2021	In particular sphingolipids, glycerophospholipids, TCA cycle intermediates, and amino acids, which are key players in the atherosclerotic process and progression, were upregulated in saline alone HFD ApoE-/- group, while were sensibly decreased after treatment with SP6 peptide.	Glycerophospholipids	29-49	apolipoprotein E	Mus musculus	200-204
33086624-2	2020	In principle, PLA2 has the capacity to hydrolyze the sn-2 position of glycerophospholipids to release fatty acids and lysophospholipids, yet several enzymes in this superfamily catalyze other reactions rather than or in addition to the PLA2 reaction.	Glycerophospholipids	70-90	phospholipase A2 group IB	Homo sapiens	14-18
33002451-2	2021	Two sites are involved in manifestation of PLA2 enzymatic activity: catalytic site responsible for substrate binding and fatty acid cleavage from the sn-2 position of a glycerophospholipid, and interface binding site (IBS) responsible for the protein binding to lipid membrane.	Glycerophospholipids	169-188	phospholipase A2 group IB	Homo sapiens	43-47
33263931-2	2020	Cytokines/chemokines excite phospholipase A2 and cyclooxygenases (COX), facilitating the release of arachidonic acid (AA) and docosahexaenoic acid (DHA) from membrane glycerophospholipids, in which the former is oxidized to produce pro-inflammatory eicosanoids (prostaglandins, leukotrienes and thromboxane"s), which intensify the neuroinflammatory events in the brain.	Glycerophospholipids	167-187	phospholipase A2 group IB	Homo sapiens	28-44
33261190-5	2020	Untargeted metabolomics showed that carbon tetrachloride (CCl4)-induced liver fibrosis promotes changes in the hepatic metabolome, specifically in glycerophospholipids and sphingolipids.	Glycerophospholipids	147-167	C-C motif chemokine ligand 4	Homo sapiens	58-62
32999028-7	2020	These results indicated that PE biosynthesis mediated by Pcyt2 was required for efficient HSV-1 envelopment in the cytoplasm of infected cells and for viral replication and pathogenicity in vivo The results also identified the PE biosynthetic pathway as a possible novel target for antiviral therapy of HSV-associated diseases and raised an interesting possibility for meclizine repositioning for treatment of these diseases, since it is an over-the-counter drug that has been used for decades against nausea and vertigo in motion sickness.IMPORTANCE Glycerophospholipids in cell membranes and virus envelopes often affect viral entry and budding.	Glycerophospholipids	551-571	phosphate cytidylyltransferase 2, ethanolamine	Homo sapiens	57-62
33203880-4	2020	The tyrosine phosphorylation of lipin-1 markedly increases its PAP activity, accelerating the synthesis of glycerophospholipids and triglyceride.	Glycerophospholipids	107-127	lipin 1	Homo sapiens	32-39
33203880-4	2020	The tyrosine phosphorylation of lipin-1 markedly increases its PAP activity, accelerating the synthesis of glycerophospholipids and triglyceride.	Glycerophospholipids	107-127	PDGFA associated protein 1	Homo sapiens	63-66
33182594-6	2020	To our surprise, despite the inhibition of FAS, which is involved in palmitate production, the cells increase their fatty acids and glycerophospholipids contents endogenously.	Glycerophospholipids	132-152	fatty acid synthase	Homo sapiens	43-46
33235638-8	2020	Due to the critical role of glycerophospholipid metabolism in oxidative stress, significant negative correlations were discovered between glycerophospholipid metabolites and three oxidative stress products (SOD, MPO, and 8-iso-PGF2alpha).	Glycerophospholipids	28-47	myeloperoxidase	Homo sapiens	212-215
33086624-2	2020	In principle, PLA2 has the capacity to hydrolyze the sn-2 position of glycerophospholipids to release fatty acids and lysophospholipids, yet several enzymes in this superfamily catalyze other reactions rather than or in addition to the PLA2 reaction.	Glycerophospholipids	70-90	phospholipase A2 group IB	Homo sapiens	236-240
32814707-3	2020	Hydrolysis of the sn-2 substituent of glycerophospholipids by iPLA2beta can lead to the generation of oxidized lipids (eicosanoids), pro- and antiinflammatory, which can initiate and amplify immune responses triggering beta cell death.	Glycerophospholipids	38-58	phospholipase A2 group VI	Homo sapiens	62-71
32661085-3	2020	Here, we demonstrate that Dnf3p is a flippase that catalyzes translocation of major glycerophospholipids, including phosphatidylserine, towards the cytosolic membrane leaflet.	Glycerophospholipids	84-104	aminophospholipid-translocating P4-type ATPase DNF3	Saccharomyces cerevisiae S288C	26-31
32080341-1	2020	Lipin-1 is an Mg2+-dependent phosphatidate phosphatase (PAP1) that catalyzes a critical step in the synthesis of glycerophospholipids and is also a cotranscriptional regulator.	Glycerophospholipids	113-133	lipin 1	Homo sapiens	0-7
32450431-1	2020	The natural bioactive glycerophospholipid lysophosphatidic acid (LPA) binds to its cognate G protein-coupled receptors (GPCRs) on the cell surface to promote the activation of several transcription factors, including NF-kappaB.	Glycerophospholipids	22-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	217-226
32425919-9	2020	Changes in gut microbiome leaded to changes in glycerophospholipid metabolism level, which may affect the expression of immune-related cytokines IFN-gamma and IL-2 in the tumor microenvironment, resulting in a different therapeutic effect of PD-1 antibody.	Glycerophospholipids	47-66	programmed cell death 1	Mus musculus	242-246
32425919-10	2020	Our findings show that changes in the gut microbiome affect the glycerophospholipid metabolic pathway, thereby regulating the therapeutic potential of PD-1 antibody in the immunotherapy of MSS-type CRC tumor-bearing mice.	Glycerophospholipids	64-83	programmed cell death 1	Mus musculus	151-155
32233382-0	2020	Coupling Headgroup and Alkene Specific Solution Modifications with Gas-Phase Ion/Ion Reactions for Sensitive Glycerophospholipid Identification and Characterization.	Glycerophospholipids	109-128	gastrin	Bos taurus	67-70
31830503-2	2020	PLD enzymes catalyze the hydrolysis of the phosphodiester bond of glycerophospholipids producing phosphatidic acid and the free headgroup.	Glycerophospholipids	66-86	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
32117065-2	2020	BSCL type 1 (BSCL1) is caused by mutations in AGPAT2, encoding 1-acylglycerol-3phosphate-O-acyltransferase beta (recently renamed lysophosphatidic acid acyltransferase beta), which catalyzes the transformation of lysophosphatidic acid in phosphatidic acid, the precursor of glycerophospholipids and triglycerides.	Glycerophospholipids	274-294	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	0-11
32117065-2	2020	BSCL type 1 (BSCL1) is caused by mutations in AGPAT2, encoding 1-acylglycerol-3phosphate-O-acyltransferase beta (recently renamed lysophosphatidic acid acyltransferase beta), which catalyzes the transformation of lysophosphatidic acid in phosphatidic acid, the precursor of glycerophospholipids and triglycerides.	Glycerophospholipids	274-294	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	13-18
32117065-2	2020	BSCL type 1 (BSCL1) is caused by mutations in AGPAT2, encoding 1-acylglycerol-3phosphate-O-acyltransferase beta (recently renamed lysophosphatidic acid acyltransferase beta), which catalyzes the transformation of lysophosphatidic acid in phosphatidic acid, the precursor of glycerophospholipids and triglycerides.	Glycerophospholipids	274-294	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	46-52
32117065-2	2020	BSCL type 1 (BSCL1) is caused by mutations in AGPAT2, encoding 1-acylglycerol-3phosphate-O-acyltransferase beta (recently renamed lysophosphatidic acid acyltransferase beta), which catalyzes the transformation of lysophosphatidic acid in phosphatidic acid, the precursor of glycerophospholipids and triglycerides.	Glycerophospholipids	274-294	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	130-172
32080341-1	2020	Lipin-1 is an Mg2+-dependent phosphatidate phosphatase (PAP1) that catalyzes a critical step in the synthesis of glycerophospholipids and is also a cotranscriptional regulator.	Glycerophospholipids	113-133	lipin 1	Homo sapiens	56-60
31373204-4	2019	The results of comprehensive analyses showed that 19 metabolites were significantly changed in A549/DDP versus A549 cells, and some pathways had a close relationship with cisplatin resistance, such as the biosynthesis of aminoacyl-tRNA, glycerophospholipid metabolism, and glutathione metabolism.	Glycerophospholipids	237-256	translocase of inner mitochondrial membrane 8A	Homo sapiens	100-103
31434739-8	2019	Upon Paigen diet challenge, male Fancd2-/-  mice had altered expression of genes encoding hepatic bile acid transporters and cholesterol and fatty acid metabolism proteins, including, Scp2/x, Abcg5/8, Abca1, Ldlr, Srebf1, and Scd-1 Untargeted lipidomic profiling in liver tissue revealed 132 lipid species, including sphingolipids, glycerophospholipids and glycerolipids, that differed significantly in abundance depending on Fancd2 status in male mice.	Glycerophospholipids	332-352	Fanconi anemia, complementation group D2	Mus musculus	33-39
31888078-8	2019	Metabolomics revealed alterations in different metabolites (mainly sphingolipids and glycerophospholipids) in cells overexpressing TDP-43.	Glycerophospholipids	85-105	TAR DNA binding protein	Homo sapiens	131-137
31431652-9	2019	On pathway analysis, the leading regulated pathways in Asic3+/+ mice were taurine and hypotaurine, cysteine and methionine, glycerophospholipid, and ascorbate and aldarate metabolisms, and the major pathways in Asic3-/- mice involved amino acid-related metabolism.	Glycerophospholipids	124-143	acid-sensing (proton-gated) ion channel 3	Mus musculus	55-60
31638497-2	2019	We explored if maternal prenatal supplementation and children"s genetic variation in seventeen SNP of the FADS1, FADS2 and FADS3 gene cluster influence twenty-one of the most relevant cheek cells" derived FA in glycerophospholipids (GPL-FA).	Glycerophospholipids	211-231	fatty acid desaturase 1	Homo sapiens	106-111
31638497-2	2019	We explored if maternal prenatal supplementation and children"s genetic variation in seventeen SNP of the FADS1, FADS2 and FADS3 gene cluster influence twenty-one of the most relevant cheek cells" derived FA in glycerophospholipids (GPL-FA).	Glycerophospholipids	211-231	fatty acid desaturase 3	Homo sapiens	123-128
30010011-1	2019	Phospholipase A2s are enzymes that hydrolyze the fatty acid at the sn-2 position of the glycerol backbone of membrane glycerophospholipids.	Glycerophospholipids	118-138	phospholipase A2 group IB	Homo sapiens	0-16
31115486-1	2019	Lysophosphatidic acid (LPA), a simple water-soluble glycerophospholipid with growth factor-like activity, regulates certain behaviors of multiple cancer types by binding to its receptor, LPA receptor 2 (LPA2).	Glycerophospholipids	52-71	lysophosphatidic acid receptor 2	Homo sapiens	187-201
31115486-1	2019	Lysophosphatidic acid (LPA), a simple water-soluble glycerophospholipid with growth factor-like activity, regulates certain behaviors of multiple cancer types by binding to its receptor, LPA receptor 2 (LPA2).	Glycerophospholipids	52-71	lysophosphatidic acid receptor 2	Homo sapiens	203-207
30952800-4	2019	ATG2A can bind tens of glycerophospholipids at once and transfers lipids robustly in vitro.	Glycerophospholipids	23-43	autophagy related 2A	Homo sapiens	0-5
30954631-17	2019	CONCLUSION AND IMPLICATIONS: Serelaxin (human recombinant relaxin-2) treatment induces significant changes in cardiac major components of the membrane lipid bilayer such as glycerophospholipids and sphingolipids, known to have structural roles but also very relevant regulatory effects in cardiac function.	Glycerophospholipids	173-193	relaxin 2	Homo sapiens	58-67
30905348-1	2019	Phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of ester bonds at sn-2 positions of glycerophospholipids (PL), producing free fatty acids and lysophospholipids.	Glycerophospholipids	92-112	phospholipase A2 group IB	Homo sapiens	0-16
30905348-1	2019	Phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of ester bonds at sn-2 positions of glycerophospholipids (PL), producing free fatty acids and lysophospholipids.	Glycerophospholipids	92-112	phospholipase A2 group IB	Homo sapiens	18-22
30445242-6	2019	Additionally, significant upregulation of PC, PE and PS with the same fatty acid chains of 18:0/18:2 was found after exposure to 0.05 mug mL-1 and 20 mug mL-1 PCB153 at 120 h. This study revealed that PCB153 exposure modulated 22 endogenous glycerophospholipids in PC12 cells and provided the basis for the further study of PCB153 on the effects of glycerophospholipids on PC12 cells.	Glycerophospholipids	241-261	L1 cell adhesion molecule	Mus musculus	138-149
31031582-9	2019	Genes such as PLA2G6 and SCARB2, which are involved in glycerophospholipid and sphingolipid metabolism either directly or indirectly are associated with risk of PD.	Glycerophospholipids	55-74	phospholipase A2 group VI	Homo sapiens	14-20
31031582-9	2019	Genes such as PLA2G6 and SCARB2, which are involved in glycerophospholipid and sphingolipid metabolism either directly or indirectly are associated with risk of PD.	Glycerophospholipids	55-74	scavenger receptor class B member 2	Homo sapiens	25-31
30517655-8	2019	Liposome-based assays showed that several anionic glycerophospholipids, including PS, phosphatidic acid and phosphatidylinositol 4,5-bisphosphate, enhance the Ca2+-dependent binding of purified cPLA2e to liposome membrane and stimulate its N-acyltransferase activity.	Glycerophospholipids	50-70	phospholipase A2 group IVA	Homo sapiens	194-199
30893912-10	2019	TSPO deletion led to up-regulation of fatty acids and glycerophospholipids, which in turn possibly affected the cell membrane fluidity and stability.	Glycerophospholipids	54-74	translocator protein	Homo sapiens	0-4
30959437-3	2019	Phospholipase A2 (PLA2) are lipolytic enzymes that hydrolyze glycerophospholipids to produce free fatty acids and lysophospholipids that have been found to be critical for many biological processes.	Glycerophospholipids	61-81	LOC104974671	Bos taurus	0-16
30959437-3	2019	Phospholipase A2 (PLA2) are lipolytic enzymes that hydrolyze glycerophospholipids to produce free fatty acids and lysophospholipids that have been found to be critical for many biological processes.	Glycerophospholipids	61-81	LOC104974671	Bos taurus	18-22
30445242-6	2019	Additionally, significant upregulation of PC, PE and PS with the same fatty acid chains of 18:0/18:2 was found after exposure to 0.05 mug mL-1 and 20 mug mL-1 PCB153 at 120 h. This study revealed that PCB153 exposure modulated 22 endogenous glycerophospholipids in PC12 cells and provided the basis for the further study of PCB153 on the effects of glycerophospholipids on PC12 cells.	Glycerophospholipids	349-369	L1 cell adhesion molecule	Mus musculus	138-149
30813330-1	2019	Acyl-CoA:glycerol-sn-3-phosphate acyltransferase (GPAT) is an enzyme responsible for the rate-limiting step in the synthesis of glycerophospholipids and triacylglycerol (TAG).	Glycerophospholipids	128-148	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	0-48
30813330-1	2019	Acyl-CoA:glycerol-sn-3-phosphate acyltransferase (GPAT) is an enzyme responsible for the rate-limiting step in the synthesis of glycerophospholipids and triacylglycerol (TAG).	Glycerophospholipids	128-148	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	50-54
30226904-5	2018	The best-characterized member of this family is lipin1, which cooperates with lipin2 to maintain glycerophospholipid homeostasis in the liver.	Glycerophospholipids	97-116	lipin 1	Homo sapiens	48-54
30415113-6	2019	PCB 126 modulated glycerophospholipid metabolism, glutathione metabolism, and CoA biosynthesis pathways irrespective of diet; indicating that the disturbance in lipid metabolism and thiol metabolites are general markers of PCB 126 exposure irrespective of liver health.	Glycerophospholipids	18-37	pyruvate carboxylase	Mus musculus	0-3
30508304-0	2019	Self-glycerophospholipids activate murine phospholipid-reactive T cells and inhibit iNKT cell activation by competing with ligands for CD1d loading.	Glycerophospholipids	5-25	CD1d1 antigen	Mus musculus	135-139
30508304-1	2019	Glycosphingolipids and glycerophospholipids bind CD1d.	Glycerophospholipids	23-43	CD1d1 antigen	Mus musculus	49-53
30508304-7	2019	Moreover, the increased flexibility of the two acyl chains in diacylglycerol ligands and a less stringent-binding orientation for glycerophospholipids as compared with the bindings of glycosphingolipids may allow glycerophospholipids to readily occupy CD1d.	Glycerophospholipids	130-150	CD1d1 antigen	Mus musculus	252-256
30508304-7	2019	Moreover, the increased flexibility of the two acyl chains in diacylglycerol ligands and a less stringent-binding orientation for glycerophospholipids as compared with the bindings of glycosphingolipids may allow glycerophospholipids to readily occupy CD1d.	Glycerophospholipids	213-233	CD1d1 antigen	Mus musculus	252-256
30460213-5	2018	The MFGM is enriched with glycerophospholipids, sphingolipids, cholesterol, and proteins, some of which are glycosylated, and are known to exert numerous biological roles.	Glycerophospholipids	26-46	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	4-8
30308051-1	2018	BACKGROUND: Plasmalogens are either phosphatidylcholine (PC P) or phosphatidylethanolamine (PE P) glycerophospholipids containing a vinyl ether moiety in sn-1-position and an esterified fatty acid in sn-2 position.	Glycerophospholipids	98-118	prolyl endopeptidase	Homo sapiens	92-96
30319454-5	2018	AGPAT2 encodes for an acyltransferase implicated in the biosynthesis of triacylglycerol and glycerophospholipids.	Glycerophospholipids	92-112	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	0-6
30508304-10	2019	Such superior ability of self-glycerophospholipids to compete with iNKT-cell ligands to occupy CD1d may help maintain homeostasis between the diverse subsets of lipid-reactive T cells, with important pathogenetic and therapeutic implications.	Glycerophospholipids	30-50	CD1d1 antigen	Mus musculus	95-99
30226904-5	2018	The best-characterized member of this family is lipin1, which cooperates with lipin2 to maintain glycerophospholipid homeostasis in the liver.	Glycerophospholipids	97-116	lipin 2	Homo sapiens	78-84
30218046-3	2018	Microbes induce monounsaturated fatty acid generation by stearoyl-CoA desaturase 1 and polyunsaturated fatty acid elongation by fatty acid elongase 5, leading to significant alterations in glycerophospholipid acyl-chain profiles.	Glycerophospholipids	189-208	stearoyl-Coenzyme A desaturase 1	Mus musculus	57-82
30830367-10	2018	These metabolites, mainly involved in fatty acid metabolism, glycerophospholipid metabolism, alanine, aspartate and glutamate metabolism, are implicated in insulin resistance, vascular remodeling, macrophage activation and oxidised LDL formation.	Glycerophospholipids	61-80	insulin	Homo sapiens	156-163
28638995-1	2018	BACKGROUND: Docosahexaenoic (C22:6) and arachidonic (C20:4) acids are long-chain polyunsaturated fatty acids (LC-PUFA) essential to neonatal development, being present in the glycerophospholipids of all organs, particularly the brain.	Glycerophospholipids	175-195	pumilio RNA binding family member 3	Homo sapiens	113-117
29908837-0	2018	Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia.	Glycerophospholipids	48-67	1-acylglycerol-3-phosphate O-acyltransferase 2	Homo sapiens	14-20
29908837-0	2018	Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia.	Glycerophospholipids	48-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-136
29949447-7	2018	Autophagy and vacuole fusion are restored by increasing phosphatidylethanolamine biosynthesis via alternative pathways, indicating that retrograde sorting by the Snx4 family sorting nexins maintains glycerophospholipid homeostasis required for autophagy and fusion competence of the vacuole membrane.	Glycerophospholipids	199-218	Snx4p	Saccharomyces cerevisiae S288C	162-166
29540574-7	2018	The structural dataset of the lipidomes, whose regioisomers were distinguished, exhibit a uniquely defined distribution of acyl chains within each lipid class; that is, sn-1 and sn-2 in the cases of glycerophospholipids or sn-2 and (sn-1, sn-3) in the cases of triacylglycerols.	Glycerophospholipids	199-219	solute carrier family 38 member 3	Homo sapiens	169-173
29844165-5	2018	Here, we report that PEPCK-M-dependent glycerol phosphate formation from noncarbohydrate precursors (glyceroneogenesis) occurs in starved lung cancer cells and supports de novo glycerophospholipid synthesis.	Glycerophospholipids	177-196	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	21-28
29844165-6	2018	Using stable isotope-labeled glutamine and lactate, we show that PEPCK-M generates phosphoenolpyruvate and 3-phosphoglycerate, which are at least partially converted to glycerol phosphate and incorporated into glycerophospholipids (GPL) under glucose and serum starvation.	Glycerophospholipids	210-230	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	65-72
29844165-6	2018	Using stable isotope-labeled glutamine and lactate, we show that PEPCK-M generates phosphoenolpyruvate and 3-phosphoglycerate, which are at least partially converted to glycerol phosphate and incorporated into glycerophospholipids (GPL) under glucose and serum starvation.	Glycerophospholipids	232-235	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	65-72
29844165-7	2018	This pathway is required to maintain levels of GPL, especially phosphatidylethanolamine (PE), as shown by stable shRNA-mediated silencing of PEPCK-M in H23 lung cancer cells.	Glycerophospholipids	47-50	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	141-148
28651830-4	2018	Maternal plasma n-3:n-6 PUFA ratio and n-3 and n-6 PUFA percentage in glycerophospholipids in mid-pregnancy were related to fetal growth velocity calculated from repeatedly measured weight, length and head circumference, birth weight, and duration of pregnancy.	Glycerophospholipids	70-90	pumilio RNA binding family member 3	Homo sapiens	51-55
29540574-7	2018	The structural dataset of the lipidomes, whose regioisomers were distinguished, exhibit a uniquely defined distribution of acyl chains within each lipid class; that is, sn-1 and sn-2 in the cases of glycerophospholipids or sn-2 and (sn-1, sn-3) in the cases of triacylglycerols.	Glycerophospholipids	199-219	solute carrier family 38 member 5	Homo sapiens	178-182
29459896-10	2018	Pathway analysis highlighted the riboflavin, purine, and glycerolipid/glycerophospholipid metabolisms as the most altered pathways with high impact in G6PD-.	Glycerophospholipids	70-89	glucose-6-phosphate dehydrogenase	Homo sapiens	151-155
29514688-1	2018	The plasmalogens are a class of glycerophospholipids which contain a vinyl-ether and an ester bond at the sn-1 and sn-2 positions, respectively, in the glycerol backbone.	Glycerophospholipids	32-52	solute carrier family 38 member 3	Homo sapiens	106-110
29514688-1	2018	The plasmalogens are a class of glycerophospholipids which contain a vinyl-ether and an ester bond at the sn-1 and sn-2 positions, respectively, in the glycerol backbone.	Glycerophospholipids	32-52	solute carrier family 38 member 5	Homo sapiens	115-119
29413580-8	2018	Glycerophospholipid metabolism, tryptophan metabolism and purine metabolism were highlighted as 3 major altered pathways in CTCL serum.	Glycerophospholipids	0-19	TSPY like 2	Homo sapiens	124-128
29528397-9	2018	PCK1, ANGPTL3, EEF1A2, and TNFAIP8L3 could influence backfat thickness through phospholipid transport, regulation of lipid metabolic process through the glycerophospholipid biosynthesis and metabolism pathway, the metabolism of lipids and lipoproteins pathway.	Glycerophospholipids	153-172	phosphoenolpyruvate carboxykinase 1	Sus scrofa	0-4
29528397-9	2018	PCK1, ANGPTL3, EEF1A2, and TNFAIP8L3 could influence backfat thickness through phospholipid transport, regulation of lipid metabolic process through the glycerophospholipid biosynthesis and metabolism pathway, the metabolism of lipids and lipoproteins pathway.	Glycerophospholipids	153-172	angiopoietin like 3	Sus scrofa	6-13
29167338-11	2018	We obtained evidence to show that a cellular phospholipase, cPLA2alpha, which releases fatty acid from the sn-2 position of membrane-associated glycerophospholipids, is critically involved in coronavirus replication, most likely by producing lysophospholipids that are required to form the specialized membrane compartments in which viral RNA synthesis takes place.	Glycerophospholipids	144-164	phospholipase A2 group IVA	Homo sapiens	60-70
29104115-1	2018	iPLA2gamma, calcium-independent phospholipase A2gamma, discerningly hydrolyses glycerophospholipids to liberate free fatty acids.	Glycerophospholipids	79-99	patatin-like phospholipase domain containing 8	Rattus norvegicus	0-53
29136407-1	2018	BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt.	Glycerophospholipids	70-90	phospholipase D1	Homo sapiens	12-36
29379441-5	2017	Our results demonstrated that the petroleum ether fraction of Bupleuri Radix (PBR) produces an antidepressant effect through regulating glycometabolism, amino acid metabolism, sphingolipid metabolism, glycerophospholipid metabolism, and fatty acid metabolism.	Glycerophospholipids	201-220	translocator protein	Rattus norvegicus	78-81
29379441-7	2017	The altered lysine degradation, sphingolipid metabolism, glycerophospholipid metabolism, fatty acid metabolism, and bile acid metabolism could be at least partly responsible for the PBR toxic responses in healthy rats.	Glycerophospholipids	57-76	translocator protein	Rattus norvegicus	182-185
29487891-5	2018	Design and methods: Phospholipase A1 (PLA1) hydrolyzes ester (acyl) bond at the sn-1 position of glycerophospholipids, but it does not act on ether bond at the sn-1 position.	Glycerophospholipids	97-117	lipase H	Homo sapiens	20-36
29487891-5	2018	Design and methods: Phospholipase A1 (PLA1) hydrolyzes ester (acyl) bond at the sn-1 position of glycerophospholipids, but it does not act on ether bond at the sn-1 position.	Glycerophospholipids	97-117	lipase H	Homo sapiens	38-42
29136407-1	2018	BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt.	Glycerophospholipids	70-90	phospholipase D1	Homo sapiens	38-44
29136407-1	2018	BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt.	Glycerophospholipids	70-90	mechanistic target of rapamycin kinase	Homo sapiens	212-216
29136407-1	2018	BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt.	Glycerophospholipids	70-90	AKT serine/threonine kinase 1	Homo sapiens	221-224
29136407-1	2018	BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt.	Glycerophospholipids	70-90	AKT serine/threonine kinase 1	Homo sapiens	225-228
29262542-5	2017	The results of integrated analysis indicated that three metabolic pathways, including tricarboxylic acid (TCA) cycle, fatty acid metabolism and glycerophospholipid metabolism, exhibited obvious upregulation in SPOP-mutated PCT tissues.	Glycerophospholipids	144-163	speckle type BTB/POZ protein	Homo sapiens	210-214
29232555-4	2017	In particular, mTORC2 stimulated sphingolipid (glucosylceramide) and glycerophospholipid (cardiolipin) synthesis.	Glycerophospholipids	69-88	CREB regulated transcription coactivator 2	Mus musculus	15-21
28830769-1	2017	Ethanolamine plasmalogens (PlsEtn) are a class of glycerophospholipids characterized by a vinyl-ether bond at the sn-1 position that play an important role in the structure and function of membranes.	Glycerophospholipids	50-70	solute carrier family 38, member 3	Mus musculus	114-118
29044196-5	2017	WACNA identified the interplay between transcript and metabolite subnetworks linked to lipid metabolism, inflammation and glycerophospholipid metabolism that were associated with IL6, AMPK and PPAR signal pathways.	Glycerophospholipids	122-141	interleukin 6	Mus musculus	179-182
29044196-5	2017	WACNA identified the interplay between transcript and metabolite subnetworks linked to lipid metabolism, inflammation and glycerophospholipid metabolism that were associated with IL6, AMPK and PPAR signal pathways.	Glycerophospholipids	122-141	peroxisome proliferator activated receptor alpha	Mus musculus	193-197
29258435-6	2017	GhNPCs were annotated as phospholipase C, which was involved in glycerophospholipid metabolism, ether lipid metabolism, and biosynthesis of secondary metabolites.	Glycerophospholipids	64-83	phosphoinositide phospholipase C 2-like	Gossypium hirsutum	25-40
29078410-8	2017	The Mdm12-Mmm1 complex binds all glycerophospholipids except for phosphatidylethanolamine (PE) in vitro.	Glycerophospholipids	33-53	ERMES complex subunit MDM12	Saccharomyces cerevisiae S288C	4-9
29078410-8	2017	The Mdm12-Mmm1 complex binds all glycerophospholipids except for phosphatidylethanolamine (PE) in vitro.	Glycerophospholipids	33-53	ERMES complex subunit MMM1	Saccharomyces cerevisiae S288C	10-14
28432361-8	2017	We discover three additional pathways viz., Glycerophospholipid metablism, h-Efp pathway and CARM1 and Regulation of Estrogen Receptor, which can be related to the metastasis phase of breast cancer.	Glycerophospholipids	44-63	coactivator associated arginine methyltransferase 1	Homo sapiens	93-98
28416579-4	2017	Lipidomic analyses revealed that LPS causes a dramatic increase, primarily in bis(monoacylglycero)phosphate species containing long (&gt;=C20) polyunsaturated acyl-chains in macrophages, and that the limited effect observed by ACOT7 deficiency is restricted to glycerophospholipids containing 20-carbon unsaturated acyl-chains.	Glycerophospholipids	261-281	toll-like receptor 4	Mus musculus	33-36
27629593-7	2017	LPCAT1 is a key enzyme in the synthesis of PAF, as well as DPPC, a highly surface-active glycerophospholipid component of surfactant.	Glycerophospholipids	89-108	lysophosphatidylcholine acyltransferase 1	Homo sapiens	0-6
28432361-8	2017	We discover three additional pathways viz., Glycerophospholipid metablism, h-Efp pathway and CARM1 and Regulation of Estrogen Receptor, which can be related to the metastasis phase of breast cancer.	Glycerophospholipids	44-63	estrogen receptor 1	Homo sapiens	117-134
28139855-4	2017	We found a significant metabolic dysregulation including purine, pyrimidine, lysine, and glycerophospholipid metabolism pathways in astrocytes expressing an ALS-causing mutated superoxide dismutase-1 (SOD1) when co-cultured with motoneurons.	Glycerophospholipids	89-108	superoxide dismutase 1	Homo sapiens	177-199
27797973-5	2017	Patients with low glycerophospholipids presented with more systemic inflammation (C-reactive protein and fibrinogen negatively and albumin positively correlated) but less adaptive immune cell tumor infiltration (lower tumor and immune cell PD-L1 expression), less oxygenic respiration and increased triglyceride biosynthesis in tumor cells, and lower histone expressions, correlating with higher numbers of expressed genes and more transcriptional noise, a putative neo-pluripotent tumor cell phenotype.Conclusions: Low serum phospholipids and essential amino acids are correlated with worse outcome in ovarian cancer, accompanied by a specific tumor cell phenotype.	Glycerophospholipids	18-38	C-reactive protein	Homo sapiens	82-100
27797973-5	2017	Patients with low glycerophospholipids presented with more systemic inflammation (C-reactive protein and fibrinogen negatively and albumin positively correlated) but less adaptive immune cell tumor infiltration (lower tumor and immune cell PD-L1 expression), less oxygenic respiration and increased triglyceride biosynthesis in tumor cells, and lower histone expressions, correlating with higher numbers of expressed genes and more transcriptional noise, a putative neo-pluripotent tumor cell phenotype.Conclusions: Low serum phospholipids and essential amino acids are correlated with worse outcome in ovarian cancer, accompanied by a specific tumor cell phenotype.	Glycerophospholipids	18-38	fibrinogen beta chain	Homo sapiens	105-115
27797973-5	2017	Patients with low glycerophospholipids presented with more systemic inflammation (C-reactive protein and fibrinogen negatively and albumin positively correlated) but less adaptive immune cell tumor infiltration (lower tumor and immune cell PD-L1 expression), less oxygenic respiration and increased triglyceride biosynthesis in tumor cells, and lower histone expressions, correlating with higher numbers of expressed genes and more transcriptional noise, a putative neo-pluripotent tumor cell phenotype.Conclusions: Low serum phospholipids and essential amino acids are correlated with worse outcome in ovarian cancer, accompanied by a specific tumor cell phenotype.	Glycerophospholipids	18-38	CD274 molecule	Homo sapiens	240-245
28286957-5	2017	The levels of free fatty acids, glycerolipids, and glycerophospholipids directly correlated with the level of serum triglyceride and inversely correlated with the levels of total cholesterol and eGFR.	Glycerophospholipids	51-71	epidermal growth factor receptor	Homo sapiens	195-199
28286957-11	2017	The observed increases in serum total fatty acids, glycerolipids, and glycerophospholipids levels directly correlated with increased serum triglyceride level and inversely correlated with the eGFR and triglyceride levels.	Glycerophospholipids	70-90	epidermal growth factor receptor	Homo sapiens	192-196
28139855-4	2017	We found a significant metabolic dysregulation including purine, pyrimidine, lysine, and glycerophospholipid metabolism pathways in astrocytes expressing an ALS-causing mutated superoxide dismutase-1 (SOD1) when co-cultured with motoneurons.	Glycerophospholipids	89-108	superoxide dismutase 1	Homo sapiens	201-205
29294264-3	2017	Phospholipases A2 (PLA2) hydrolyze membrane glycerophospholipids at sn-2 position releasing lysophospholipid and free fatty acid.	Glycerophospholipids	44-64	phospholipase A2 group IIA	Homo sapiens	0-17
28219337-4	2017	RESULTS: In Sst-neurons, the DEGs by nicotine were associated with glycerophospholipid and nicotinate and nicotinamide metabolism; while in Thy1-neurons those related to immune response and purine and pyrimidine metabolisms were affected.	Glycerophospholipids	67-86	somatostatin	Mus musculus	12-15
28011644-4	2017	Here, we investigated the functional regulation of ACD11 and CPTP by anionic phosphoglycerides and found that 1-palmitoyl-2-oleoyl-phosphatidic acid or 1-palmitoyl-2-oleoyl-phosphatidylglycerol (&lt;=15 mol %) in C1P source vesicles depressed C1P intermembrane transfer.	Glycerophospholipids	77-94	Glycolipid transfer protein (GLTP) family protein	Arabidopsis thaliana	51-56
28011644-4	2017	Here, we investigated the functional regulation of ACD11 and CPTP by anionic phosphoglycerides and found that 1-palmitoyl-2-oleoyl-phosphatidic acid or 1-palmitoyl-2-oleoyl-phosphatidylglycerol (&lt;=15 mol %) in C1P source vesicles depressed C1P intermembrane transfer.	Glycerophospholipids	77-94	ceramide-1-phosphate transfer protein	Homo sapiens	61-65
28011644-8	2017	These findings provide the first evidence for a potential phosphoglyceride headgroup-specific regulatory interaction site(s) existing on the surface of any GLTP-fold and delineate new differences between GLTP superfamily members that are specific for C1P versus glycolipid.	Glycerophospholipids	58-74	glycolipid transfer protein	Homo sapiens	156-160
28011644-8	2017	These findings provide the first evidence for a potential phosphoglyceride headgroup-specific regulatory interaction site(s) existing on the surface of any GLTP-fold and delineate new differences between GLTP superfamily members that are specific for C1P versus glycolipid.	Glycerophospholipids	58-74	glycolipid transfer protein	Homo sapiens	204-208
27856675-3	2017	Therefore, different PUFA supplements given to the cells resulted in very different glycerophospholipid (GPL) species profiles and substrate availability for phospholipases, which have preferences for polar head group and acyl chains when liberating PUFA precursors for production of lipid mediators.	Glycerophospholipids	84-103	pumilio RNA binding family member 3	Homo sapiens	21-25
27856675-3	2017	Therefore, different PUFA supplements given to the cells resulted in very different glycerophospholipid (GPL) species profiles and substrate availability for phospholipases, which have preferences for polar head group and acyl chains when liberating PUFA precursors for production of lipid mediators.	Glycerophospholipids	105-108	pumilio RNA binding family member 3	Homo sapiens	21-25
29129849-1	2017	The phospholipase A2 (PLA2) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids.	Glycerophospholipids	120-140	phospholipase A2 group IB	Homo sapiens	4-20
29129849-1	2017	The phospholipase A2 (PLA2) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids.	Glycerophospholipids	120-140	phospholipase A2 group IB	Homo sapiens	22-26
28202541-2	2017	Mga2 and SREBP-1 regulate triacylglycerol and glycerophospholipid synthesis, whereas Sre1 and SREBP-2 regulate sterol synthesis.	Glycerophospholipids	46-65	Mga2p	Saccharomyces cerevisiae S288C	0-4
28063498-1	2017	A family of 14-20kDa, disulfide-rich, calcium-dependent secreted phospholipases A2 (sPLA2s) that release fatty acids from the sn-2 position of glycerophospholipids can be found in mammals.	Glycerophospholipids	143-163	phospholipase A2 group IID	Homo sapiens	84-90
29294264-3	2017	Phospholipases A2 (PLA2) hydrolyze membrane glycerophospholipids at sn-2 position releasing lysophospholipid and free fatty acid.	Glycerophospholipids	44-64	phospholipase A2 group IIA	Homo sapiens	19-23
27821511-5	2016	Biochemical experiments reveal a phospholipid-binding site located along a hydrophobic channel of the Mdm12 structure and that Mdm12 might have a binding preference for glycerophospholipids harboring a positively charged head group.	Glycerophospholipids	169-189	ERMES complex subunit MDM12	Saccharomyces cerevisiae S288C	127-132
27377346-1	2016	Cytosolic phospholipase A2 alpha (cPLA2alpha) plays a key role in signaling in mammalian cells by releasing arachidonic acid (AA) from glycerophospholipids (GPLs) but the factors determining the specificity of cPLA2alpha for AA-containing GPLs are not well understood.	Glycerophospholipids	135-155	phospholipase A2 group IVA	Homo sapiens	34-44
27768866-1	2016	Prostaglandins have been characterized as the metabolic products of arachidonic acid released from glycerophospholipids following hydrolysis by phospholipase A2s and enzymatic oxidation by the COX1 and COX2.	Glycerophospholipids	99-119	phospholipase A2 group IB	Homo sapiens	144-160
27768866-1	2016	Prostaglandins have been characterized as the metabolic products of arachidonic acid released from glycerophospholipids following hydrolysis by phospholipase A2s and enzymatic oxidation by the COX1 and COX2.	Glycerophospholipids	99-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-206
27768866-1	2016	Prostaglandins have been characterized as the metabolic products of arachidonic acid released from glycerophospholipids following hydrolysis by phospholipase A2s and enzymatic oxidation by the COX1 and COX2.	Glycerophospholipids	99-119	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	193-197
27299855-1	2016	Secretory phospholipase A2 Group-IIA (sPLA2 -IIA) catalyzes the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids.	Glycerophospholipids	99-119	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	0-36
27721472-0	2016	Comprehensive Plasma Metabolomic Analyses of Atherosclerotic Progression Reveal Alterations in Glycerophospholipid and Sphingolipid Metabolism in Apolipoprotein E-deficient Mice.	Glycerophospholipids	95-114	apolipoprotein E	Mus musculus	146-162
26910604-6	2016	Principal component analysis showed that perirenal versus inguinal white adipose tissues varied in lipid composition of triacyl- and diacylglycerols, sphingomyelins, glycerophospholipids and, notably, cardiolipin CL 72:3.	Glycerophospholipids	166-186	WD and tetratricopeptide repeats 1	Mus musculus	73-80
27299855-1	2016	Secretory phospholipase A2 Group-IIA (sPLA2 -IIA) catalyzes the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids.	Glycerophospholipids	99-119	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	38-48
27189942-9	2016	While using phospholipase D inhibitors (which block the conversion of glycerophospholipids to phosphatidic acid) to deplete cellular TRE, we observed that, upon inhibitor washout, there was a rapid and dramatic regeneration of MICAL-L1-marked TRE.	Glycerophospholipids	70-90	MICAL like 1	Homo sapiens	227-235
27220631-1	2016	Cytosolic phospholipases A2 (cPLA2s) consist of a family of calcium-sensitive enzymes that function to generate lipid second messengers through hydrolysis of membrane-associated glycerophospholipids.	Glycerophospholipids	178-198	phospholipase A2 group IVD	Homo sapiens	29-34
27256689-0	2016	Insertion of perilipin 3 into a glycero(phospho)lipid monolayer depends on lipid headgroup and acyl chain species.	Glycerophospholipids	32-53	perilipin 3	Homo sapiens	13-24
27078024-1	2016	Calcium-independent phospholipase A2beta (iPLA2beta, PLA2G6) is essential for the remodeling of membrane glycerophospholipids.	Glycerophospholipids	105-125	phospholipase A2, group VI	Mus musculus	42-51
27053105-4	2016	In mammals, SREBP-2 controls cholesterol biosynthesis, whereas SREBP-1 controls triacylglycerol and glycerophospholipid biosynthesis.	Glycerophospholipids	100-119	sterol regulatory element binding transcription factor 1	Homo sapiens	63-70
27078024-1	2016	Calcium-independent phospholipase A2beta (iPLA2beta, PLA2G6) is essential for the remodeling of membrane glycerophospholipids.	Glycerophospholipids	105-125	phospholipase A2, group VI	Mus musculus	53-59
26838385-8	2016	Interestingly, LPCs were up-regulated and PCs and TGs were down-regulated, compared OC group with benign tumor and normal control groups, and the glycerophospholipid metabolism emerged as a key pathway, in particular, the phospholipase A2 (PLA2) enzyme activity, that was disregulated in the disease.	Glycerophospholipids	146-165	phospholipase A2 group IB	Homo sapiens	222-238
26838385-8	2016	Interestingly, LPCs were up-regulated and PCs and TGs were down-regulated, compared OC group with benign tumor and normal control groups, and the glycerophospholipid metabolism emerged as a key pathway, in particular, the phospholipase A2 (PLA2) enzyme activity, that was disregulated in the disease.	Glycerophospholipids	146-165	phospholipase A2 group IB	Homo sapiens	240-244
26934370-1	2016	The special glycerophospholipids plasmalogens (Pls) are enriched in the brain and reported to prevent neuronal cell death by enhancing phosphorylation of Akt and ERK signaling in neuronal cells.	Glycerophospholipids	12-32	AKT serine/threonine kinase 1	Homo sapiens	154-157
26934370-1	2016	The special glycerophospholipids plasmalogens (Pls) are enriched in the brain and reported to prevent neuronal cell death by enhancing phosphorylation of Akt and ERK signaling in neuronal cells.	Glycerophospholipids	12-32	mitogen-activated protein kinase 1	Homo sapiens	162-165
26370417-7	2015	The results uncovered altered nodes in lipid-driven proinflammatory cascades, such as glycosphingolipid and glycerophospholipid synthesis, governed by the beta-1,4-galactosyltransferase (B4GALT6), the phospholipase 2gamma (PLA2G4C) and the choline/ethanolamine phosphotransferase (CEPT1) enzymes.	Glycerophospholipids	108-127	beta-1,4-galactosyltransferase 6	Homo sapiens	187-194
27725450-2	2016	We herein investigated the effects of several glycerophospholipids on human recombinant CerK activity with CaCl2 and MgCl2 by measuring the formation of fluorescent labeled C1P in vitro.	Glycerophospholipids	46-66	ceramide kinase	Homo sapiens	88-92
26840539-10	2016	Choline phosphotransferase 1 (Chpt1) was enriched in glycerophospholipid metabolism pathway.	Glycerophospholipids	53-72	choline phosphotransferase 1	Homo sapiens	0-28
26840539-10	2016	Choline phosphotransferase 1 (Chpt1) was enriched in glycerophospholipid metabolism pathway.	Glycerophospholipids	53-72	choline phosphotransferase 1	Homo sapiens	30-35
27141409-1	2016	The PLA2G6 gene encodes a group VIA calcium independent phospholipase A2 (iPLA2beta), which hydrolyses glycerophospholipids to release fatty acids and lysophospholipids.	Glycerophospholipids	103-123	phospholipase A2 group VI	Homo sapiens	4-10
25482049-0	2016	Regulation of Calcium-Independent Phospholipase A2 Expression by Adrenoceptors and Sterol Regulatory Element Binding Protein-Potential Crosstalk Between Sterol and Glycerophospholipid Mediators.	Glycerophospholipids	164-183	patatin like phospholipase domain containing 2	Homo sapiens	14-50
25482049-0	2016	Regulation of Calcium-Independent Phospholipase A2 Expression by Adrenoceptors and Sterol Regulatory Element Binding Protein-Potential Crosstalk Between Sterol and Glycerophospholipid Mediators.	Glycerophospholipids	164-183	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	83-124
25482049-1	2016	Calcium-independent phospholipase A2 (iPLA2) is an 85-kDa enzyme that releases docosahexaenoic acid (DHA) from glycerophospholipids.	Glycerophospholipids	111-131	patatin like phospholipase domain containing 2	Homo sapiens	0-36
25482049-1	2016	Calcium-independent phospholipase A2 (iPLA2) is an 85-kDa enzyme that releases docosahexaenoic acid (DHA) from glycerophospholipids.	Glycerophospholipids	111-131	patatin like phospholipase domain containing 2	Homo sapiens	38-43
25482049-8	2016	Together, results indicate that stimulation of adrenoreceptors causes increased iPLA2 expression via MAP kinase/ERK 1/2 and SREBP, and suggest a possible mechanism for effect of CNS noradrenaline on neural plasticity and crosstalk between sterol and glycerophospholipid mediators, that may play a role in physiological or pathophysiological processes in the brain and other organs.	Glycerophospholipids	250-269	patatin like phospholipase domain containing 2	Homo sapiens	80-85
26711221-2	2016	Secretory phospholipases A2 (sPLA2"s) hydrolyse glycerophospholipids and release pro-inflammatory lyso-lipids, oxidized and non-oxidized fatty acids and isoprostanes.	Glycerophospholipids	48-68	phospholipase A2 group IID	Homo sapiens	29-36
26370417-7	2015	The results uncovered altered nodes in lipid-driven proinflammatory cascades, such as glycosphingolipid and glycerophospholipid synthesis, governed by the beta-1,4-galactosyltransferase (B4GALT6), the phospholipase 2gamma (PLA2G4C) and the choline/ethanolamine phosphotransferase (CEPT1) enzymes.	Glycerophospholipids	108-127	phospholipase A2 group IVC	Homo sapiens	223-230
26370417-7	2015	The results uncovered altered nodes in lipid-driven proinflammatory cascades, such as glycosphingolipid and glycerophospholipid synthesis, governed by the beta-1,4-galactosyltransferase (B4GALT6), the phospholipase 2gamma (PLA2G4C) and the choline/ethanolamine phosphotransferase (CEPT1) enzymes.	Glycerophospholipids	108-127	choline/ethanolamine phosphotransferase 1	Homo sapiens	281-286
26212365-6	2015	Furthermore, mechanistic studies identified Tlr4 signaling as the responsible pathway mediating the effect of glycerophospholipids.	Glycerophospholipids	110-130	toll like receptor 4	Homo sapiens	44-48
26322624-2	2015	Previous studies have reported that lowering ether lipid levels by genetic ablation of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS) lowers key structural and oncogenic ether lipid levels and alters fatty acid, glycerophospholipid, and eicosanoid metabolism to impair cancer pathogenicity, indicating that AGPS may be a potential therapeutic target for cancer.	Glycerophospholipids	241-260	alkylglycerone phosphate synthase	Homo sapiens	121-155
26322624-2	2015	Previous studies have reported that lowering ether lipid levels by genetic ablation of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS) lowers key structural and oncogenic ether lipid levels and alters fatty acid, glycerophospholipid, and eicosanoid metabolism to impair cancer pathogenicity, indicating that AGPS may be a potential therapeutic target for cancer.	Glycerophospholipids	241-260	alkylglycerone phosphate synthase	Homo sapiens	157-161
26452545-7	2015	Gene ontology (GO) enrichment and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis showed that the SDE genes were most enrichment in steroid biosynthesis, PPAR signaling pathway, biosynthesis of unsaturated fatty acids, glycerophospholipid metabolism, three amino acid pathways, and pyruvate metabolism (P &lt;= 0.05).	Glycerophospholipids	235-254	peroxisome proliferator activated receptor alpha	Gallus gallus	170-174
26416244-2	2015	Cytosolic phospholipase A2alpha (cPLA2alpha) is an enzyme that hydrolyzes membrane glycerophospholipids to release arachidonic acid and lysophospholipids that are implicated in cancer cell proliferation.	Glycerophospholipids	83-103	phospholipase A2 group IVA	Homo sapiens	33-43
26503625-2	2015	All HRASLS family members possess in vitro phospholipid metabolizing abilities including phospholipase A1/2 (PLA1/2) activities and O-acyltransferase activities for the remodeling of glycerophospholipid acyl chains, as well as N-acyltransferase activities for the production of N-acylphosphatidylethanolamines.	Glycerophospholipids	183-202	phospholipase A and acyltransferase 1	Homo sapiens	4-10
26503625-2	2015	All HRASLS family members possess in vitro phospholipid metabolizing abilities including phospholipase A1/2 (PLA1/2) activities and O-acyltransferase activities for the remodeling of glycerophospholipid acyl chains, as well as N-acyltransferase activities for the production of N-acylphosphatidylethanolamines.	Glycerophospholipids	183-202	lipase H	Homo sapiens	89-107
26503625-2	2015	All HRASLS family members possess in vitro phospholipid metabolizing abilities including phospholipase A1/2 (PLA1/2) activities and O-acyltransferase activities for the remodeling of glycerophospholipid acyl chains, as well as N-acyltransferase activities for the production of N-acylphosphatidylethanolamines.	Glycerophospholipids	183-202	POU class 2 homeobox 3	Homo sapiens	109-115
26016666-2	2015	We report this for coupled refolding and bilayer insertion of outer membrane phospholipase A (OmpLA), an integral membrane enzyme that catalyses the hydrolytic cleavage of glycerophospholipids.	Glycerophospholipids	172-192	phospholipase A and acyltransferase 1	Homo sapiens	77-92
25904332-4	2015	One of the candidate genes that was consistently up-regulated in cellular models of SREBP1c-induced cilium repression was phospholipase A2 group III (PLA2G3), a phospholipase that hydrolyzes the sn-2 position of glycerophospholipids.	Glycerophospholipids	212-232	sterol regulatory element binding transcription factor 1	Homo sapiens	84-91
26381418-1	2015	H-rev107 is a member of the HREV107 type II tumor suppressor gene family and acts as a phospholipase to catalyze the release of fatty acids from glycerophospholipid.	Glycerophospholipids	145-164	phospholipase A and acyltransferase 3	Homo sapiens	0-8
26295742-6	2015	In parallel, we profiled PAR-mediated changes in glycerophospholipid (GPL) mass with and without giripladib to better understand cPLA2alpha-mediated lipid metabolism.	Glycerophospholipids	49-68	nuclear receptor subfamily 1 group I member 2	Homo sapiens	25-28
26295742-6	2015	In parallel, we profiled PAR-mediated changes in glycerophospholipid (GPL) mass with and without giripladib to better understand cPLA2alpha-mediated lipid metabolism.	Glycerophospholipids	70-73	nuclear receptor subfamily 1 group I member 2	Homo sapiens	25-28
25681634-1	2015	Oxysterol-binding protein (OSBP) and its homologues (ORPs) are lipid-binding/transfer proteins with affinity for oxysterols, cholesterol and glycerophospholipids.	Glycerophospholipids	141-161	oxysterol binding protein	Homo sapiens	0-25
25681634-1	2015	Oxysterol-binding protein (OSBP) and its homologues (ORPs) are lipid-binding/transfer proteins with affinity for oxysterols, cholesterol and glycerophospholipids.	Glycerophospholipids	141-161	oxysterol binding protein	Homo sapiens	27-31
26356733-7	2015	Normal weight people had significantly increased FabK (p = 0.027), and the glycerophospholipid metabolism pathway revealed the presence of phospholipase A1 only in the control group (p = 0.05).	Glycerophospholipids	75-94	lipase H	Homo sapiens	139-155
25782660-7	2015	The GIF group demonstrated significantly higher glycerophospholipid species containing myristic acid [LPC(14:0), PC(14:0/18:1), PC(16:0/14:0)] and palmitoleic acid [LPC(16:1), PC(16:0/16:1), and PC(16:1/18:1)] than the VIF group.	Glycerophospholipids	48-67	cobalamin binding intrinsic factor	Homo sapiens	4-7
26001724-1	2015	The PLA2G6 gene encodes a group VIA calcium-independent phospholipase A2 beta enzyme that selectively hydrolyses glycerophospholipids to release free fatty acids.	Glycerophospholipids	113-133	phospholipase A2 group VI	Homo sapiens	4-10
25904332-4	2015	One of the candidate genes that was consistently up-regulated in cellular models of SREBP1c-induced cilium repression was phospholipase A2 group III (PLA2G3), a phospholipase that hydrolyzes the sn-2 position of glycerophospholipids.	Glycerophospholipids	212-232	phospholipase A2 group III	Homo sapiens	122-148
25904332-4	2015	One of the candidate genes that was consistently up-regulated in cellular models of SREBP1c-induced cilium repression was phospholipase A2 group III (PLA2G3), a phospholipase that hydrolyzes the sn-2 position of glycerophospholipids.	Glycerophospholipids	212-232	phospholipase A2 group III	Homo sapiens	150-156
25474166-6	2015	Further pathway impact analysis determined glycerophospholipid metabolism as the main potential target pathway of estradiol, which was further confirmed by LCAT (phosphatidylcholine-sterol acyltransferase) activity changes and lipid peroxidative product (MDA, methane dicarboxylic aldehyde) changes caused by estradiol.	Glycerophospholipids	43-62	lecithin cholesterol acyltransferase	Mus musculus	156-160
25512002-6	2015	iPLA2 s are critical mediators of a variety of cellular processes including growth, metabolism, and lipid second messenger generation, exerting their functions through catalyzing the cleavage of the acyl groups in glycerophospholipids.	Glycerophospholipids	214-234	phospholipase A2 group VI	Homo sapiens	0-5
25474166-6	2015	Further pathway impact analysis determined glycerophospholipid metabolism as the main potential target pathway of estradiol, which was further confirmed by LCAT (phosphatidylcholine-sterol acyltransferase) activity changes and lipid peroxidative product (MDA, methane dicarboxylic aldehyde) changes caused by estradiol.	Glycerophospholipids	43-62	lecithin cholesterol acyltransferase	Mus musculus	162-204
26106800-2	2015	A bacterial glycerophospholipid: cholesterol acyltransferase fused with a mitochondria-targeting sequence and a membrane-spanning domain of the mitochondrial inner membrane protein Pet100 and enhanced green fluorescent protein was expressed in a Saccharomyces cerevisiae mutant deleted for ARE1 and ARE2 encoding acyl-CoA:sterol acyltransferases.	Glycerophospholipids	12-31	sterol acyltransferase	Saccharomyces cerevisiae S288C	290-294
26106800-2	2015	A bacterial glycerophospholipid: cholesterol acyltransferase fused with a mitochondria-targeting sequence and a membrane-spanning domain of the mitochondrial inner membrane protein Pet100 and enhanced green fluorescent protein was expressed in a Saccharomyces cerevisiae mutant deleted for ARE1 and ARE2 encoding acyl-CoA:sterol acyltransferases.	Glycerophospholipids	12-31	sterol acyltransferase	Saccharomyces cerevisiae S288C	299-303
26397899-2	2015	Huntingtin associates with membranes and can interact directly with glycerophospholipids in membranes.	Glycerophospholipids	68-88	huntingtin	Mus musculus	0-10
25533115-1	2014	Phospholipase A(2) (PLA(2)) are enzymes that hydrolyze the ester bond of glycerophospholipids releasing free fatty acids and lysophospholipids, including the arachidonic acid, the precursor of the eicosanoids and the inflammatory cascades.	Glycerophospholipids	73-93	phospholipase A2 group IB	Homo sapiens	0-18
25327529-0	2015	Regulation of NF-kappaB signaling by oxidized glycerophospholipid and IL-1beta induced miRs-21-3p and -27a-5p in human aortic endothelial cells.	Glycerophospholipids	46-65	nuclear factor kappa B subunit 1	Homo sapiens	14-23
25533115-1	2014	Phospholipase A(2) (PLA(2)) are enzymes that hydrolyze the ester bond of glycerophospholipids releasing free fatty acids and lysophospholipids, including the arachidonic acid, the precursor of the eicosanoids and the inflammatory cascades.	Glycerophospholipids	73-93	phospholipase A2 group IB	Homo sapiens	20-26
25180675-1	2014	Calcium independent phospholipase A2 (iPLA2) is an 85 kDa protein that catalyzes the hydrolysis of the sn-2 acyl ester bond of glycerophospholipids to liberate free fatty acids and lysophospholipids.	Glycerophospholipids	127-147	patatin like phospholipase domain containing 2	Homo sapiens	0-36
25180675-1	2014	Calcium independent phospholipase A2 (iPLA2) is an 85 kDa protein that catalyzes the hydrolysis of the sn-2 acyl ester bond of glycerophospholipids to liberate free fatty acids and lysophospholipids.	Glycerophospholipids	127-147	phospholipase A2 group VI	Homo sapiens	38-43
24470352-7	2014	These genes were mapped within eight significant pathways identified, including insulin signaling, type 1 diabetes, and glycerophospholipid metabolism.	Glycerophospholipids	120-139	insulin	Homo sapiens	80-87
25202277-3	2014	BK alpha (slo1) subunits are sufficient to support current perturbation by fatty and epoxyeicosatrienoic acids, glycerophospholipids and cholesterol, while distinct BK beta subunits seem necessary for current modulation by most steroids.	Glycerophospholipids	112-132	FCF1 rRNA-processing protein	Homo sapiens	0-8
25202277-3	2014	BK alpha (slo1) subunits are sufficient to support current perturbation by fatty and epoxyeicosatrienoic acids, glycerophospholipids and cholesterol, while distinct BK beta subunits seem necessary for current modulation by most steroids.	Glycerophospholipids	112-132	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	10-14
24824606-12	2014	For the glycerophospholipids, phosphatidylserine was the only species that was lower in GLTP overexpressing cells.	Glycerophospholipids	8-28	glycolipid transfer protein	Homo sapiens	88-92
24939539-1	2014	Phospholipases A2 (PLA2) belong to a superfamily of enzymes that catalyze the hydrolysis of glycerophospholipids at the sn-2 position, producing nonesterified fatty acids and lysophospholipids.	Glycerophospholipids	92-112	phospholipase A2 group IIA	Homo sapiens	19-23
25014274-3	2014	LPL1/YOR059c contains lipase specific motif GXSXG and acetate labeling in the LPL1 overexpressed strains depicted a decrease in glycerophospholipids and an increase in free fatty acids.	Glycerophospholipids	128-148	putative hydrolase	Saccharomyces cerevisiae S288C	0-4
25014274-3	2014	LPL1/YOR059c contains lipase specific motif GXSXG and acetate labeling in the LPL1 overexpressed strains depicted a decrease in glycerophospholipids and an increase in free fatty acids.	Glycerophospholipids	128-148	putative hydrolase	Saccharomyces cerevisiae S288C	78-82
25014274-4	2014	The purified Lpl1p showed phospholipase activity with broader substrate specificity, acting on all glycerophospholipids primarily at sn-2 position and later at sn-1 position.	Glycerophospholipids	99-119	putative hydrolase	Saccharomyces cerevisiae S288C	13-18
26019578-1	2014	Secreted Phospholipases A2 (sPLA2s) represent a large family of structurally related enzymes, which target different tissues and organs and induce numerous pharmacological effects based on their catalytic specificity - hydrolysis of the sn-2 ester bond of glycerophospholipids.	Glycerophospholipids	256-276	phospholipase A2 group IID	Homo sapiens	28-34
24861084-6	2014	Whether these autoantibodies affect the activity of PLA2, which liberates arachidonic acid from glycerophospholipids and modulates podocyte function, is unknown.	Glycerophospholipids	96-116	phospholipase A2 group IB	Homo sapiens	52-56
24847877-8	2014	Importantly, structural analysis complemented by mass spectrometry revealed the presence of glycerophospholipids in the E-SYT2 SMP channel, indicating a direct role for E-SYTs in lipid transport.	Glycerophospholipids	92-112	extended synaptotagmin 2	Homo sapiens	120-126
23747420-1	2013	Phospholipases A2 (PLA2) catalyze the hydrolytic cleavage of free fatty acids from the sn-2 OH-moiety of glycerophospholipids.	Glycerophospholipids	105-125	phospholipase A2 group IB	Homo sapiens	19-23
24269233-2	2013	To identify human acyl-CoA synthetases (ACSs) involved in S1P metabolism, we cloned all 26 human ACS genes and examined their abilities to restore deficient sphingolipid-to-glycerophospholipid metabolism in a yeast mutant lacking two ACS genes, FAA1 and FAA4.	Glycerophospholipids	173-192	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	40-43
24095738-5	2013	Using combined in vivo lipidomic identification and in vitro enzymology approaches, we show that ABHD6 can hydrolyze several lipid substrates, positioning ABHD6 at the interface of glycerophospholipid metabolism and lipid signal transduction.	Glycerophospholipids	181-200	abhydrolase domain containing 6	Mus musculus	97-102
24095738-5	2013	Using combined in vivo lipidomic identification and in vitro enzymology approaches, we show that ABHD6 can hydrolyze several lipid substrates, positioning ABHD6 at the interface of glycerophospholipid metabolism and lipid signal transduction.	Glycerophospholipids	181-200	abhydrolase domain containing 6	Mus musculus	155-160
24205231-0	2013	Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146.	Glycerophospholipids	55-74	transcription factor 7 like 2	Homo sapiens	114-143
23766516-9	2013	These results strongly suggest that Acsl4 activates EETs to form EET-CoAs that are incorporated into glycerophospholipids, thereby sequestering EETs.	Glycerophospholipids	101-121	acyl-CoA synthetase long-chain family member 4	Rattus norvegicus	36-41
23250786-7	2013	Transcriptomic profiles after n-3 PUFA supplementation indicate changes in glycerophospholipid metabolism in both subgroups and sphingolipid metabolism in non-responders.	Glycerophospholipids	75-94	pumilio RNA binding family member 3	Homo sapiens	34-38
24486543-3	2014	DGKgamma showed a strong binding activity compared with other DGK isozymes for phosphatidic acid (PA) among the various glycerophospholipids tested.	Glycerophospholipids	120-140	diacylglycerol kinase beta	Homo sapiens	0-3
24128332-1	2013	Autotaxin (ATX) generates lysophosphatidic acid (LPA) from glycerophospholipid via lysophospholipase D (lysoPLD) activity in cooperation with phospholipase A.	Glycerophospholipids	59-78	ectonucleotide pyrophosphatase/phosphodiesterase 2	Rattus norvegicus	0-9
24128332-1	2013	Autotaxin (ATX) generates lysophosphatidic acid (LPA) from glycerophospholipid via lysophospholipase D (lysoPLD) activity in cooperation with phospholipase A.	Glycerophospholipids	59-78	ectonucleotide pyrophosphatase/phosphodiesterase 2	Rattus norvegicus	11-14
24128332-1	2013	Autotaxin (ATX) generates lysophosphatidic acid (LPA) from glycerophospholipid via lysophospholipase D (lysoPLD) activity in cooperation with phospholipase A.	Glycerophospholipids	59-78	ectonucleotide pyrophosphatase/phosphodiesterase 2	Rattus norvegicus	83-102
24196413-6	2013	Most recently, Osh6p and Osh7p were demonstrated to show specific affinity for phosphatidylserine (PS), and to play a role in the intracellular transport of this glycerophospholipid; Additionally, two mammalian ORPs were shown to bind PS.	Glycerophospholipids	162-181	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	15-20
24196413-6	2013	Most recently, Osh6p and Osh7p were demonstrated to show specific affinity for phosphatidylserine (PS), and to play a role in the intracellular transport of this glycerophospholipid; Additionally, two mammalian ORPs were shown to bind PS.	Glycerophospholipids	162-181	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	25-30
23980144-4	2013	We demonstrate that ablation of AGPS in cancer cells results in reduced cell survival, cancer aggressiveness, and tumor growth through altering the balance of ether lipid, fatty acid, eicosanoid, and fatty acid-derived glycerophospholipid metabolism, resulting in an overall reduction in the levels of several oncogenic signaling lipids.	Glycerophospholipids	219-238	alkylglycerone phosphate synthase	Homo sapiens	32-36
23727005-1	2013	Phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of the sn-2 ester linkage of glycerophospholipids to produce fatty acids and lysophospholipids.	Glycerophospholipids	85-105	phospholipase A2 group IB	Homo sapiens	0-16
23727005-1	2013	Phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of the sn-2 ester linkage of glycerophospholipids to produce fatty acids and lysophospholipids.	Glycerophospholipids	85-105	phospholipase A2 group IB	Homo sapiens	18-22
23698096-3	2013	Asymmetry and diversity of membrane glycerophospholipids are generated in the remodelling pathway (Lands" cycle), which are conducted by the concerted actions of phospholipases A2 (PLA2s) and lysophospholipid acyltransferases (LPLATs).	Glycerophospholipids	36-56	phospholipase A2 group IIA	Homo sapiens	181-186
23580142-2	2013	Among putative LXR target genes, lysophosphatidylcholine acyltransferase 3 (LPCAT3) involved in the Lands cycle controls the fatty acid composition at the sn-2 position of glycerophospholipids and, therefore, the availability of fatty acids, such as arachidonic acid (AA), used for eicosanoid synthesis.	Glycerophospholipids	172-192	lysophosphatidylcholine acyltransferase 3	Homo sapiens	33-74
23580142-2	2013	Among putative LXR target genes, lysophosphatidylcholine acyltransferase 3 (LPCAT3) involved in the Lands cycle controls the fatty acid composition at the sn-2 position of glycerophospholipids and, therefore, the availability of fatty acids, such as arachidonic acid (AA), used for eicosanoid synthesis.	Glycerophospholipids	172-192	lysophosphatidylcholine acyltransferase 3	Homo sapiens	76-82
23208369-0	2012	Lysophosphatidylcholine acyltransferase 3 is the key enzyme for incorporating arachidonic acid into glycerophospholipids during adipocyte differentiation.	Glycerophospholipids	100-120	lysophosphatidylcholine acyltransferase 3	Mus musculus	0-41
23549332-5	2013	For example, commonly used head group-specific analysis of glycerophospholipids (GP) by low-resolution instruments is neither capable of differentiating the fatty acids linked to the glycerol backbone nor able to define their bond type (ester, alkyl-, or alk-1-enyl-ether).	Glycerophospholipids	81-83	secretory leukocyte peptidase inhibitor	Homo sapiens	255-260
23425575-3	2013	In the known metabolic pathway in mammals, anandamide and other bioactive N-acylethanolamines, such as palmitoylethanolamide and oleoylethanolamide, are biosynthesized from glycerophospholipids by a combination of Ca(2+)-dependent N-acyltransferase and N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, and are degraded by fatty acid amide hydrolase.	Glycerophospholipids	173-193	N-acyl phosphatidylethanolamine phospholipase D	Homo sapiens	253-312
23079583-7	2013	PUFA supplementation of L6 cells led to an increase in myogenic differentiation correlated to an incorporation of added PUFAs in TM and DRM glycerophospholipids.	Glycerophospholipids	140-160	pumilio RNA binding family member 3	Homo sapiens	0-4
23268448-8	2013	Via TEAK we identified a nonlinear glycerophospholipid metabolism subpathway involving the SLC1 gene, which we found via mutational analysis to be required for yeast filamentous growth.	Glycerophospholipids	35-54	1-acylglycerol-3-phosphate O-acyltransferase SLC1	Saccharomyces cerevisiae S288C	91-95
23267081-1	2013	Lipin 1 is a coregulator of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that catalyzes a critical step in the synthesis of glycerophospholipids.	Glycerophospholipids	165-185	lipin 1	Mus musculus	0-7
23022039-1	2013	Phospholipase A(2) (PLA(2)) enzymes catalyze the hydrolysis of the sn-2 position of glycerophospholipids to produce free fatty acids and lysophospholipids.	Glycerophospholipids	84-104	phospholipase A2 group IB	Homo sapiens	0-18
23022039-1	2013	Phospholipase A(2) (PLA(2)) enzymes catalyze the hydrolysis of the sn-2 position of glycerophospholipids to produce free fatty acids and lysophospholipids.	Glycerophospholipids	84-104	phospholipase A2 group IB	Homo sapiens	20-26
23501167-6	2013	Sct1p-catalyzed acyl chain exchange, the acyl-CoA binding protein Acb1p, the Plb1p homologue Plb2p, and the glycerophospholipid:triacylglycerol transacylase Lro1p were not required for PC remodeling.	Glycerophospholipids	108-127	bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1	Saccharomyces cerevisiae S288C	0-5
23179391-1	2013	Glycerol 3-phosphate acyltransferase-1 (GPAT-1) catalyzes the initial and rate-limiting step in de novo glycerophospholipid and triacylglycerol (TAG) biosynthesis.	Glycerophospholipids	104-123	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	0-38
23179391-1	2013	Glycerol 3-phosphate acyltransferase-1 (GPAT-1) catalyzes the initial and rate-limiting step in de novo glycerophospholipid and triacylglycerol (TAG) biosynthesis.	Glycerophospholipids	104-123	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	40-46
22740689-0	2012	A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions.	Glycerophospholipids	38-57	ras homolog family member A	Homo sapiens	123-127
22349267-4	2012	Compared to iPLA(2)beta(+/+) mice, iPLA(2)beta(-/-) mice showed decreased rates of incorporation of unesterified DHA from plasma into brain phospholipids, reduced concentrations of several fatty acids (including DHA) esterified in ethanolamine- and serine-glycerophospholipids, and increased lysophospholipid fatty acid concentrations.	Glycerophospholipids	256-276	phospholipase A2, group VI	Mus musculus	35-46
22706677-1	2012	Secretory phospholipases A(2) (sPLA(2)s) are a diverse family of low molecular mass enzymes (13-18 kDa) that hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce free fatty acids and lysophospholipids.	Glycerophospholipids	153-173	phospholipase A2 group IID	Homo sapiens	31-39
22921619-3	2012	The milk fat globule membrane (MFGM) thus comprises membrane-specific proteins and polar lipids (glycerophospholipids and sphingolipids) surrounding a core of neutral lipids (mainly triacylglycerols and cholesterol esters).	Glycerophospholipids	97-117	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	31-35