PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31913757-4	2020	TGFbeta induced rapid decreases in PI(4,5)P2 at the plasma membrane (PM) with increases in PI(4)P, followed by increases in PI(3,4)P2, in a TGFbeta receptor kinase ALK5-dependent manner.	phosphoinositide-3,4-bisphosphate	124-133	transforming growth factor alpha	Homo sapiens	0-7
31913757-4	2020	TGFbeta induced rapid decreases in PI(4,5)P2 at the plasma membrane (PM) with increases in PI(4)P, followed by increases in PI(3,4)P2, in a TGFbeta receptor kinase ALK5-dependent manner.	phosphoinositide-3,4-bisphosphate	124-133	transforming growth factor alpha	Homo sapiens	140-147
31913757-4	2020	TGFbeta induced rapid decreases in PI(4,5)P2 at the plasma membrane (PM) with increases in PI(4)P, followed by increases in PI(3,4)P2, in a TGFbeta receptor kinase ALK5-dependent manner.	phosphoinositide-3,4-bisphosphate	124-133	transforming growth factor beta receptor 1	Homo sapiens	164-168
31913757-7	2020	Interestingly, PI3K-C2alpha KD abolished not only TGFbeta-induced PI(3,4)P2 increases but also TGFbeta-induced synaptojanin1 recruitment to the PM, PI(4,5)P2 decreases, and PI(4)P increases.	phosphoinositide-3,4-bisphosphate	66-75	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	15-27
31913757-7	2020	Interestingly, PI3K-C2alpha KD abolished not only TGFbeta-induced PI(3,4)P2 increases but also TGFbeta-induced synaptojanin1 recruitment to the PM, PI(4,5)P2 decreases, and PI(4)P increases.	phosphoinositide-3,4-bisphosphate	66-75	transforming growth factor alpha	Homo sapiens	50-57
31212584-4	2019	IRTKS suppresses SHIP2 phosphatase to convert phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3, PIP3) to phosphatidylinositol (3,4) bisphosphate (PI(3,4)P2).	phosphoinositide-3,4-bisphosphate	150-159	BAR/IMD domain containing adaptor protein 2 like 1	Homo sapiens	0-5
31318314-0	2019	PI3Kbeta links integrin activation and PI(3,4)P2 production during invadopodial maturation.	phosphoinositide-3,4-bisphosphate	39-48	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	0-8
31318314-6	2019	Surprisingly, these integrin-stimulated and PI3Kbeta-dependent responses require the production of PI(3,4)P2 by the phosphoinositide 5"-phosphatase SHIP2.	phosphoinositide-3,4-bisphosphate	99-108	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	44-52
31318314-6	2019	Surprisingly, these integrin-stimulated and PI3Kbeta-dependent responses require the production of PI(3,4)P2 by the phosphoinositide 5"-phosphatase SHIP2.	phosphoinositide-3,4-bisphosphate	99-108	inositol polyphosphate phosphatase like 1	Homo sapiens	148-153
31318314-7	2019	Thus, integrin activation of PI3Kbeta is coupled to the SHIP2-dependent production of PI(3,4)P2, which regulates the recruitment of PH domain-containing scaffolds such as lamellipodin to invadopodia.	phosphoinositide-3,4-bisphosphate	86-95	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	29-37
31318314-7	2019	Thus, integrin activation of PI3Kbeta is coupled to the SHIP2-dependent production of PI(3,4)P2, which regulates the recruitment of PH domain-containing scaffolds such as lamellipodin to invadopodia.	phosphoinositide-3,4-bisphosphate	86-95	inositol polyphosphate phosphatase like 1	Homo sapiens	56-61
31831620-3	2020	Here, combining live imaging, genome engineering, and acute chemical and genetic manipulations, we found that local synthesis of PI(3,4)P2 by phosphatidylinositol 3-kinase C2alpha at plasma membrane clathrin-coated pits is spatially segregated from its hydrolysis by the PI(3,4)P2-specific inositol polyphosphate 4-phosphatase 4A (INPP4A).	phosphoinositide-3,4-bisphosphate	129-138	inositol polyphosphate-4-phosphatase type I A	Homo sapiens	290-329
31831620-3	2020	Here, combining live imaging, genome engineering, and acute chemical and genetic manipulations, we found that local synthesis of PI(3,4)P2 by phosphatidylinositol 3-kinase C2alpha at plasma membrane clathrin-coated pits is spatially segregated from its hydrolysis by the PI(3,4)P2-specific inositol polyphosphate 4-phosphatase 4A (INPP4A).	phosphoinositide-3,4-bisphosphate	129-138	inositol polyphosphate-4-phosphatase type I A	Homo sapiens	331-337
31831620-6	2020	These results reveal a function for INPP4-mediated PI(3,4)P2 hydrolysis in local regulation of growth factor and nutrient signals at endosomes in cancer cells.	phosphoinositide-3,4-bisphosphate	51-60	inositol polyphosphate-4-phosphatase type I A	Homo sapiens	36-41
31664099-2	2019	SHIP2 is a phosphoinositide-metabolizing enzyme, which dephosphorylates PI(3,4,5)P3 resulting to PI(3,4)P2, and it has been recently shown that Abeta directly increases the activity of SHIP2.	phosphoinositide-3,4-bisphosphate	97-106	inositol polyphosphate phosphatase-like 1	Mus musculus	0-5
31664099-2	2019	SHIP2 is a phosphoinositide-metabolizing enzyme, which dephosphorylates PI(3,4,5)P3 resulting to PI(3,4)P2, and it has been recently shown that Abeta directly increases the activity of SHIP2.	phosphoinositide-3,4-bisphosphate	97-106	histocompatibility 2, class II antigen A, beta 1	Mus musculus	144-149
31664099-2	2019	SHIP2 is a phosphoinositide-metabolizing enzyme, which dephosphorylates PI(3,4,5)P3 resulting to PI(3,4)P2, and it has been recently shown that Abeta directly increases the activity of SHIP2.	phosphoinositide-3,4-bisphosphate	97-106	inositol polyphosphate phosphatase-like 1	Mus musculus	185-190
31664099-3	2019	Here we monitored, utilizing fluorescent SHIP2 biosensor, real-time increase of PI(3,4)P2-containing vesicles in HT22 cells treated with Abeta.	phosphoinositide-3,4-bisphosphate	80-89	inositol polyphosphate phosphatase-like 1	Mus musculus	41-46
31664099-3	2019	Here we monitored, utilizing fluorescent SHIP2 biosensor, real-time increase of PI(3,4)P2-containing vesicles in HT22 cells treated with Abeta.	phosphoinositide-3,4-bisphosphate	80-89	histocompatibility 2, class II antigen A, beta 1	Mus musculus	137-142
31664099-5	2019	We further discovered that ARAP3 can be attracted to PI(3,4)P2-positive mature endosomes via its PH domain and this facilitates the degradation of ARAP3.	phosphoinositide-3,4-bisphosphate	53-62	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	Mus musculus	27-32
31664099-5	2019	We further discovered that ARAP3 can be attracted to PI(3,4)P2-positive mature endosomes via its PH domain and this facilitates the degradation of ARAP3.	phosphoinositide-3,4-bisphosphate	53-62	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	Mus musculus	147-152
31357665-2	2019	The protein SH2 domain containing inositol 5-phosphatase 2 (SHIP2) belongs to the family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	162-171	inositol polyphosphate phosphatase like 1	Homo sapiens	12-58
31357665-2	2019	The protein SH2 domain containing inositol 5-phosphatase 2 (SHIP2) belongs to the family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	162-171	inositol polyphosphate phosphatase like 1	Homo sapiens	60-65
31147387-2	2019	Canonically, Akt is activated by phosphoinositide-dependent kinase 1 and mechanistic target of rapamycin complex 2, which phosphorylate it on two regulatory residues in its kinase domain upon targeting of Akt to the plasma membrane by PI(3,4,5)P3 Recent evidence, however, has shown that, in addition to phosphorylation, Akt activity is allosterically coupled to the engagement of PI(3,4,5)P3 or PI(3,4)P2 in cellular membranes.	phosphoinositide-3,4-bisphosphate	396-405	AKT serine/threonine kinase 1	Homo sapiens	13-16
31147387-2	2019	Canonically, Akt is activated by phosphoinositide-dependent kinase 1 and mechanistic target of rapamycin complex 2, which phosphorylate it on two regulatory residues in its kinase domain upon targeting of Akt to the plasma membrane by PI(3,4,5)P3 Recent evidence, however, has shown that, in addition to phosphorylation, Akt activity is allosterically coupled to the engagement of PI(3,4,5)P3 or PI(3,4)P2 in cellular membranes.	phosphoinositide-3,4-bisphosphate	396-405	AKT serine/threonine kinase 1	Homo sapiens	205-208
31147387-2	2019	Canonically, Akt is activated by phosphoinositide-dependent kinase 1 and mechanistic target of rapamycin complex 2, which phosphorylate it on two regulatory residues in its kinase domain upon targeting of Akt to the plasma membrane by PI(3,4,5)P3 Recent evidence, however, has shown that, in addition to phosphorylation, Akt activity is allosterically coupled to the engagement of PI(3,4,5)P3 or PI(3,4)P2 in cellular membranes.	phosphoinositide-3,4-bisphosphate	396-405	AKT serine/threonine kinase 1	Homo sapiens	205-208
31147387-4	2019	Thus, Akt activity is restricted to membranes containing either PI(3,4,5)P3 or PI(3,4)P2 While PI(3,4,5)P3 has long been associated with signaling at the plasma membrane, PI(3,4)P2 is gaining increasing traction as a signaling lipid and has been implicated in controlling Akt activity throughout the endomembrane system.	phosphoinositide-3,4-bisphosphate	79-88	AKT serine/threonine kinase 1	Homo sapiens	6-9
31147387-4	2019	Thus, Akt activity is restricted to membranes containing either PI(3,4,5)P3 or PI(3,4)P2 While PI(3,4,5)P3 has long been associated with signaling at the plasma membrane, PI(3,4)P2 is gaining increasing traction as a signaling lipid and has been implicated in controlling Akt activity throughout the endomembrane system.	phosphoinositide-3,4-bisphosphate	171-180	AKT serine/threonine kinase 1	Homo sapiens	6-9
31212584-4	2019	IRTKS suppresses SHIP2 phosphatase to convert phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3, PIP3) to phosphatidylinositol (3,4) bisphosphate (PI(3,4)P2).	phosphoinositide-3,4-bisphosphate	150-159	inositol polyphosphate phosphatase like 1	Homo sapiens	17-22
31212584-5	2019	IRTKS-knockout significantly increases PI(3,4)P2 level and decreases cellular PI(3,4,5)P3 content.	phosphoinositide-3,4-bisphosphate	39-48	BAR/IMD domain containing adaptor protein 2 like 1	Homo sapiens	0-5
31034465-1	2019	PIK3C2A is a class II member of the phosphoinositide 3-kinase (PI3K) family that catalyzes the phosphorylation of phosphatidylinositol (PI) into PI(3)P and the phosphorylation of PI(4)P into PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	191-200	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	0-7
30783101-0	2019	Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	75-84	oxysterol binding protein like 1A	Homo sapiens	26-30
30783101-5	2019	PI(4,5)P2/PI(3,4)P2 can facilitate ORP1-mediated cholesterol transport by promoting membrane targeting and cholesterol extraction.	phosphoinositide-3,4-bisphosphate	10-19	oxysterol binding protein like 1A	Homo sapiens	35-39
30487552-6	2018	PI(3,4)P2 is produced by the 5-phosphatase SHIP1 and Class-II PI3-Kinases to recruit the endocytic regulatory protein SNX9 to basolateral domains that are being remodeled into apical surfaces.	phosphoinositide-3,4-bisphosphate	0-9	inositol polyphosphate-5-phosphatase D	Homo sapiens	43-48
30487552-6	2018	PI(3,4)P2 is produced by the 5-phosphatase SHIP1 and Class-II PI3-Kinases to recruit the endocytic regulatory protein SNX9 to basolateral domains that are being remodeled into apical surfaces.	phosphoinositide-3,4-bisphosphate	0-9	sorting nexin 9	Homo sapiens	118-122
30103190-1	2018	SH2 domain-containing inositol 5"-phosphatase 2 (SHIP2) is a lipid phosphatase that produce phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) from phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3), and is involved in many diseases such as neurodegenerative diseases.	phosphoinositide-3,4-bisphosphate	131-140	inositol polyphosphate phosphatase-like 1	Mus musculus	0-47
29987362-1	2018	PTEN prevents tumor genesis by antagonizing the PI3 kinase/Akt pathway through D3 site phosphatase activity toward PI(3,4)P2 and PI(3,4,5)P3.	phosphoinositide-3,4-bisphosphate	115-124	phosphatase and tensin homolog	Homo sapiens	0-4
29987362-1	2018	PTEN prevents tumor genesis by antagonizing the PI3 kinase/Akt pathway through D3 site phosphatase activity toward PI(3,4)P2 and PI(3,4,5)P3.	phosphoinositide-3,4-bisphosphate	115-124	AKT serine/threonine kinase 1	Homo sapiens	59-62
29993167-6	2018	Taken together, we propose that the acquisition of PI(4) P and the display of PI (3,4)P2 on LPVMs initiate the machinery that supports continuous Akt activation and sensitivity to miltefosine.	phosphoinositide-3,4-bisphosphate	78-88	AKT serine/threonine kinase 1	Homo sapiens	146-149
30010242-6	2018	R-Ras1 also contributes to SopB-dependent Akt activation by promoting the localised production of PI(3,4)P2 /PI(3,4,5)P3 .	phosphoinositide-3,4-bisphosphate	98-107	AKT serine/threonine kinase 1	Homo sapiens	42-45
30103190-1	2018	SH2 domain-containing inositol 5"-phosphatase 2 (SHIP2) is a lipid phosphatase that produce phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) from phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3), and is involved in many diseases such as neurodegenerative diseases.	phosphoinositide-3,4-bisphosphate	131-140	inositol polyphosphate phosphatase-like 1	Mus musculus	49-54
29884706-7	2018	Conversely, overexpression of the C-terminal TAPP PH domains in B cells can inhibit Akt phosphorylation by a mechanism requiring the TAPP PI(3,4)P2-binding pocket.	phosphoinositide-3,4-bisphosphate	138-147	thymoma viral proto-oncogene 1	Mus musculus	84-87
30012834-4	2018	The effect of SHIP2 on migration, as observed in MDA-MB-231 cells, appears to be mediated by PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	93-102	inositol polyphosphate phosphatase like 1	Homo sapiens	14-19
29343273-9	2018	The mass of PI (3,4) P2 and PI (3) P was analyzed by ELISA upon INPP4B overexpression.	phosphoinositide-3,4-bisphosphate	12-23	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	64-70
29695412-8	2018	Finally, using activity assays, we find that dimerization alters Ci-VSP substrate specificity such that only dimeric Ci-VSP is able to dephosphorylate the 3-phosphate from PI(3,4,5)P3 or PI(3,4)P2 Our results indicate that dimerization plays a significant role in Ci-VSP function.	phosphoinositide-3,4-bisphosphate	187-196	voltage-sensor containing phosphatase	Ciona intestinalis	68-71
29695412-8	2018	Finally, using activity assays, we find that dimerization alters Ci-VSP substrate specificity such that only dimeric Ci-VSP is able to dephosphorylate the 3-phosphate from PI(3,4,5)P3 or PI(3,4)P2 Our results indicate that dimerization plays a significant role in Ci-VSP function.	phosphoinositide-3,4-bisphosphate	187-196	voltage-sensor containing phosphatase	Ciona intestinalis	120-123
29695412-8	2018	Finally, using activity assays, we find that dimerization alters Ci-VSP substrate specificity such that only dimeric Ci-VSP is able to dephosphorylate the 3-phosphate from PI(3,4,5)P3 or PI(3,4)P2 Our results indicate that dimerization plays a significant role in Ci-VSP function.	phosphoinositide-3,4-bisphosphate	187-196	voltage-sensor containing phosphatase	Ciona intestinalis	120-123
28916189-0	2018	Phosphoinositide 5-phosphatase activities control cell motility in glioblastoma: Two phosphoinositides PI(4,5)P2 and PI(3,4)P2 are involved.	phosphoinositide-3,4-bisphosphate	117-126	synaptojanin 2	Homo sapiens	0-30
28916189-6	2018	Two other PIs, PI(4,5)P2 and PI(3,4)P2, are produced or used as substrates of PI 5-phosphatases (OCRL, INPP5B, SHIP1/2, SYNJ1/2, INPP5K, INPP5J, INPP5E).	phosphoinositide-3,4-bisphosphate	29-38	OCRL inositol polyphosphate-5-phosphatase	Homo sapiens	97-101
28869677-1	2017	The SH2 domain containing inositol phosphatase 2 (SHIP2) dephosphorylates PI(3,4,5)P3 to generate PI(3,4)P2, a lipid involved in the control of cell migration and adhesion.	phosphoinositide-3,4-bisphosphate	98-107	inositol polyphosphate phosphatase like 1	Homo sapiens	4-48
28916189-6	2018	Two other PIs, PI(4,5)P2 and PI(3,4)P2, are produced or used as substrates of PI 5-phosphatases (OCRL, INPP5B, SHIP1/2, SYNJ1/2, INPP5K, INPP5J, INPP5E).	phosphoinositide-3,4-bisphosphate	29-38	inositol polyphosphate-5-phosphatase B	Homo sapiens	103-109
28916189-6	2018	Two other PIs, PI(4,5)P2 and PI(3,4)P2, are produced or used as substrates of PI 5-phosphatases (OCRL, INPP5B, SHIP1/2, SYNJ1/2, INPP5K, INPP5J, INPP5E).	phosphoinositide-3,4-bisphosphate	29-38	inositol polyphosphate-5-phosphatase D	Homo sapiens	111-118
28916189-6	2018	Two other PIs, PI(4,5)P2 and PI(3,4)P2, are produced or used as substrates of PI 5-phosphatases (OCRL, INPP5B, SHIP1/2, SYNJ1/2, INPP5K, INPP5J, INPP5E).	phosphoinositide-3,4-bisphosphate	29-38	synaptojanin 1	Homo sapiens	120-127
28916189-6	2018	Two other PIs, PI(4,5)P2 and PI(3,4)P2, are produced or used as substrates of PI 5-phosphatases (OCRL, INPP5B, SHIP1/2, SYNJ1/2, INPP5K, INPP5J, INPP5E).	phosphoinositide-3,4-bisphosphate	29-38	inositol polyphosphate-5-phosphatase K	Homo sapiens	129-135
28916189-6	2018	Two other PIs, PI(4,5)P2 and PI(3,4)P2, are produced or used as substrates of PI 5-phosphatases (OCRL, INPP5B, SHIP1/2, SYNJ1/2, INPP5K, INPP5J, INPP5E).	phosphoinositide-3,4-bisphosphate	29-38	inositol polyphosphate-5-phosphatase J	Homo sapiens	137-143
28916189-6	2018	Two other PIs, PI(4,5)P2 and PI(3,4)P2, are produced or used as substrates of PI 5-phosphatases (OCRL, INPP5B, SHIP1/2, SYNJ1/2, INPP5K, INPP5J, INPP5E).	phosphoinositide-3,4-bisphosphate	29-38	inositol polyphosphate-5-phosphatase E	Homo sapiens	145-151
28869677-1	2017	The SH2 domain containing inositol phosphatase 2 (SHIP2) dephosphorylates PI(3,4,5)P3 to generate PI(3,4)P2, a lipid involved in the control of cell migration and adhesion.	phosphoinositide-3,4-bisphosphate	98-107	inositol polyphosphate phosphatase like 1	Homo sapiens	50-55
29103771-1	2017	Tandem pH domain-containing proteins TAPP1 and TAPP2 are adaptor proteins that specifically bind to phosphatidylinositol-3,4-bisphosphate, or PI(3,4)P2, a product of phosphoinositide 3-kinases (PI3K).	phosphoinositide-3,4-bisphosphate	142-151	pleckstrin homology domain containing A1	Homo sapiens	37-42
29103771-1	2017	Tandem pH domain-containing proteins TAPP1 and TAPP2 are adaptor proteins that specifically bind to phosphatidylinositol-3,4-bisphosphate, or PI(3,4)P2, a product of phosphoinositide 3-kinases (PI3K).	phosphoinositide-3,4-bisphosphate	142-151	pleckstrin homology domain containing A2	Homo sapiens	47-52
29161595-3	2017	We demonstrate that the membrane remodeling activity of sorting nexin 9 (SNX9), a late-acting endocytic PX-BAR domain protein required for constriction of U-shaped endocytic intermediates, is controlled by an allosteric structural switch involving coincident detection of the clathrin adaptor AP2 and phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) at endocytic sites.	phosphoinositide-3,4-bisphosphate	340-349	sorting nexin 9	Homo sapiens	56-71
29161595-3	2017	We demonstrate that the membrane remodeling activity of sorting nexin 9 (SNX9), a late-acting endocytic PX-BAR domain protein required for constriction of U-shaped endocytic intermediates, is controlled by an allosteric structural switch involving coincident detection of the clathrin adaptor AP2 and phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) at endocytic sites.	phosphoinositide-3,4-bisphosphate	340-349	sorting nexin 9	Homo sapiens	73-77
29161595-5	2017	Binding to PI(3,4)P2 via its PX-BAR domain, and concomitant association with AP2 via sequences in the linker region, releases SNX9 autoinhibitory contacts to enable membrane constriction.	phosphoinositide-3,4-bisphosphate	11-20	sorting nexin 9	Homo sapiens	126-130
29057313-2	2017	Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kbeta (PI3KC2beta) represses mTORC1 identifies PI3KC2beta as a pharmacological target for the treatment of diabetes and cancer.	phosphoinositide-3,4-bisphosphate	62-71	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	124-132
28923975-3	2017	At clathrin-coated pits, PI(3)P is produced by the INPP4A hydrolysis of PI(3,4)P2, and this is necessary for actin-driven endocytosis.	phosphoinositide-3,4-bisphosphate	72-81	inositol polyphosphate-4-phosphatase type I A	Homo sapiens	51-57
29056325-6	2017	PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated cells.	phosphoinositide-3,4-bisphosphate	94-103	phosphatase and tensin homolog	Mus musculus	69-73
29056325-6	2017	PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated cells.	phosphoinositide-3,4-bisphosphate	94-103	inositol polyphosphate-4-phosphatase, type II	Mus musculus	78-84
29056325-7	2017	PTEN deletion increased PI(3,4)P2 levels in a mouse model of prostate cancer, and it inversely correlated with PI(3,4)P2 levels across several EGF-stimulated prostate and breast cancer lines.	phosphoinositide-3,4-bisphosphate	24-33	phosphatase and tensin homolog	Mus musculus	0-4
29056325-7	2017	PTEN deletion increased PI(3,4)P2 levels in a mouse model of prostate cancer, and it inversely correlated with PI(3,4)P2 levels across several EGF-stimulated prostate and breast cancer lines.	phosphoinositide-3,4-bisphosphate	111-120	phosphatase and tensin homolog	Mus musculus	0-4
29056325-8	2017	These results point to a role for PI(3,4)P2 in the phenotype caused by loss-of-function mutations or deletions in PTEN.	phosphoinositide-3,4-bisphosphate	34-43	phosphatase and tensin homolog	Mus musculus	114-118
29056325-6	2017	PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated cells.	phosphoinositide-3,4-bisphosphate	16-25	phosphatase and tensin homolog	Mus musculus	0-4
29056325-6	2017	PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated cells.	phosphoinositide-3,4-bisphosphate	16-25	inositol polyphosphate-4-phosphatase, type II	Mus musculus	78-84
29056325-6	2017	PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated cells.	phosphoinositide-3,4-bisphosphate	94-103	phosphatase and tensin homolog	Mus musculus	69-73
29056325-6	2017	PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated cells.	phosphoinositide-3,4-bisphosphate	94-103	inositol polyphosphate-4-phosphatase, type II	Mus musculus	78-84
29057313-2	2017	Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kbeta (PI3KC2beta) represses mTORC1 identifies PI3KC2beta as a pharmacological target for the treatment of diabetes and cancer.	phosphoinositide-3,4-bisphosphate	62-71	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	134-144
29057313-2	2017	Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kbeta (PI3KC2beta) represses mTORC1 identifies PI3KC2beta as a pharmacological target for the treatment of diabetes and cancer.	phosphoinositide-3,4-bisphosphate	62-71	CREB regulated transcription coactivator 1	Mus musculus	156-162
29057313-2	2017	Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kbeta (PI3KC2beta) represses mTORC1 identifies PI3KC2beta as a pharmacological target for the treatment of diabetes and cancer.	phosphoinositide-3,4-bisphosphate	62-71	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	174-184
28627515-3	2017	We show by computational modelling and super-resolution imaging that phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis within the clathrin-coated area of endocytic intermediates triggers selective recruitment of the PX-BAR domain protein SNX9, as a result of complex interactions of endocytic proteins competing for phospholipids.	phosphoinositide-3,4-bisphosphate	108-117	sorting nexin 9	Homo sapiens	248-252
28572395-4	2017	We identified phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2], synthesized by class II PI3K beta (PI3KC2beta) at LyLEs, as a negative regulator of mTORC1, whereas loss of PI3KC2beta hyperactivated mTORC1.	phosphoinositide-3,4-bisphosphate	53-62	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	89-98
28572395-4	2017	We identified phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2], synthesized by class II PI3K beta (PI3KC2beta) at LyLEs, as a negative regulator of mTORC1, whereas loss of PI3KC2beta hyperactivated mTORC1.	phosphoinositide-3,4-bisphosphate	53-62	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	100-110
28572395-4	2017	We identified phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2], synthesized by class II PI3K beta (PI3KC2beta) at LyLEs, as a negative regulator of mTORC1, whereas loss of PI3KC2beta hyperactivated mTORC1.	phosphoinositide-3,4-bisphosphate	53-62	CREB regulated transcription coactivator 1	Mus musculus	149-155
28572395-4	2017	We identified phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2], synthesized by class II PI3K beta (PI3KC2beta) at LyLEs, as a negative regulator of mTORC1, whereas loss of PI3KC2beta hyperactivated mTORC1.	phosphoinositide-3,4-bisphosphate	53-62	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	173-183
28572395-4	2017	We identified phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2], synthesized by class II PI3K beta (PI3KC2beta) at LyLEs, as a negative regulator of mTORC1, whereas loss of PI3KC2beta hyperactivated mTORC1.	phosphoinositide-3,4-bisphosphate	53-62	CREB regulated transcription coactivator 1	Mus musculus	199-205
28572395-6	2017	Local PI(3,4)P2 synthesis triggered repression of mTORC1 activity through association of Raptor with inhibitory 14-3-3 proteins.	phosphoinositide-3,4-bisphosphate	6-15	CREB regulated transcription coactivator 1	Mus musculus	50-56
28572395-6	2017	Local PI(3,4)P2 synthesis triggered repression of mTORC1 activity through association of Raptor with inhibitory 14-3-3 proteins.	phosphoinositide-3,4-bisphosphate	6-15	regulatory associated protein of MTOR complex 1	Homo sapiens	89-95
28572395-7	2017	These results unravel an unexpected function for local PI(3,4)P2 production in shutting off mTORC1.	phosphoinositide-3,4-bisphosphate	55-64	CREB regulated transcription coactivator 1	Mus musculus	92-98
28196852-0	2017	INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC.	phosphoinositide-3,4-bisphosphate	30-39	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	0-6
28196852-0	2017	INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC.	phosphoinositide-3,4-bisphosphate	30-39	phosphatase and tensin homolog	Homo sapiens	11-15
28196852-3	2017	Inositol polyphosphate-4-phosphatase type II (INPP4B) catalyzes the removal of the 4"-phosphate of phosphatidylinositol-(3, 4)-bisphosphate (PI-3,4-P2), creating phosphatidylinositol-3-phosphate.	phosphoinositide-3,4-bisphosphate	141-150	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	46-52
28196852-4	2017	There is debate concerning whether PI-3,4-P2 contributes to Akt and downstream effector activation with the known canonical signaling second messenger, phosphatidylinositol-(3, 4, 5)-trisphosphate (PIP3).	phosphoinositide-3,4-bisphosphate	35-44	AKT serine/threonine kinase 1	Homo sapiens	60-63
28196852-5	2017	If PI-3,4-P2 is a positive effector, INPP4B would be a negative regulator of PI3K signaling, and there is some evidence to support this.	phosphoinositide-3,4-bisphosphate	3-12	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	37-43
28196852-8	2017	In summary, the current investigation of INPP4B in PTEN-null TNBC suggests new mechanistic insight and the potential for targeted therapy for this aggressive subset of breast cancer.Implications: These data support a model where PI-3,4-P2 is inhibitory toward PI3K, revealing a novel feedback mechanism under conditions of excessive signaling, and potentially an indication for PI3K-beta isoform-specific inhibitors in PTEN-null TNBC that have lost INPP4B expression.	phosphoinositide-3,4-bisphosphate	229-238	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	41-47
28196852-8	2017	In summary, the current investigation of INPP4B in PTEN-null TNBC suggests new mechanistic insight and the potential for targeted therapy for this aggressive subset of breast cancer.Implications: These data support a model where PI-3,4-P2 is inhibitory toward PI3K, revealing a novel feedback mechanism under conditions of excessive signaling, and potentially an indication for PI3K-beta isoform-specific inhibitors in PTEN-null TNBC that have lost INPP4B expression.	phosphoinositide-3,4-bisphosphate	229-238	phosphatase and tensin homolog	Homo sapiens	51-55
28196852-8	2017	In summary, the current investigation of INPP4B in PTEN-null TNBC suggests new mechanistic insight and the potential for targeted therapy for this aggressive subset of breast cancer.Implications: These data support a model where PI-3,4-P2 is inhibitory toward PI3K, revealing a novel feedback mechanism under conditions of excessive signaling, and potentially an indication for PI3K-beta isoform-specific inhibitors in PTEN-null TNBC that have lost INPP4B expression.	phosphoinositide-3,4-bisphosphate	229-238	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	378-387
28196852-8	2017	In summary, the current investigation of INPP4B in PTEN-null TNBC suggests new mechanistic insight and the potential for targeted therapy for this aggressive subset of breast cancer.Implications: These data support a model where PI-3,4-P2 is inhibitory toward PI3K, revealing a novel feedback mechanism under conditions of excessive signaling, and potentially an indication for PI3K-beta isoform-specific inhibitors in PTEN-null TNBC that have lost INPP4B expression.	phosphoinositide-3,4-bisphosphate	229-238	phosphatase and tensin homolog	Homo sapiens	419-423
28196852-8	2017	In summary, the current investigation of INPP4B in PTEN-null TNBC suggests new mechanistic insight and the potential for targeted therapy for this aggressive subset of breast cancer.Implications: These data support a model where PI-3,4-P2 is inhibitory toward PI3K, revealing a novel feedback mechanism under conditions of excessive signaling, and potentially an indication for PI3K-beta isoform-specific inhibitors in PTEN-null TNBC that have lost INPP4B expression.	phosphoinositide-3,4-bisphosphate	229-238	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	449-455
28157504-4	2017	We show that binding of phosphatidylinositol-3,4,5-trisphosphate (PIP3) or PI(3,4)P2 to the PH domain allosterically activates Akt by promoting high-affinity substrate binding.	phosphoinositide-3,4-bisphosphate	75-84	AKT serine/threonine kinase 1	Homo sapiens	127-130
28247964-4	2017	Knockdown of SHIP2, a phosphatidylinositol 3,4,5-trisphosphatase (PIP3 ) 5-phosphatase that generates PI(3,4)P2 , in MDA-MB-231 breast cancer cells, induced the development of focal adhesions and cell spreading, leading to the suppression of invasion.	phosphoinositide-3,4-bisphosphate	102-111	inositol polyphosphate phosphatase like 1	Homo sapiens	13-18
28247964-5	2017	In contrast, knockdown of PTEN, a 3-phosphatase that de-phosphorylates PIP3 and PI(3,4)P2 , induced cell shrinkage and increased cell invasion.	phosphoinositide-3,4-bisphosphate	80-89	phosphatase and tensin homolog	Homo sapiens	26-30
28247964-7	2017	Overexpression of the TAPP1 PH domain, which binds to PI(3,4)P2 , and knockdown of Lpd, a downstream effector of PI(3,4)P2 , resulted in similar phenotypes to those induced by SHIP2 knockdown.	phosphoinositide-3,4-bisphosphate	54-63	pleckstrin homology domain containing A1	Homo sapiens	22-27
28247964-7	2017	Overexpression of the TAPP1 PH domain, which binds to PI(3,4)P2 , and knockdown of Lpd, a downstream effector of PI(3,4)P2 , resulted in similar phenotypes to those induced by SHIP2 knockdown.	phosphoinositide-3,4-bisphosphate	113-122	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	83-86
28130450-6	2017	Live-cell imaging reveals that Rab8a is first recruited to the plasma membrane and dorsal ruffles, but it is retained during collapse of ruffles to form macropinosomes enriched for phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) and phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), suggesting that the macropinosome is the location where Rab8a is active.	phosphoinositide-3,4-bisphosphate	279-288	RAB8A, member RAS oncogene family	Homo sapiens	31-36
28106075-9	2017	Finally, we demonstrate that neural Wiskott-Aldrich syndrome protein and the Arp2/3 complex functioned downstream of PI(3,4)P2 to mediate neuritogenesis and dendritogenesis.	phosphoinositide-3,4-bisphosphate	117-126	WASP like actin nucleation promoting factor	Homo sapiens	29-68
28106075-9	2017	Finally, we demonstrate that neural Wiskott-Aldrich syndrome protein and the Arp2/3 complex functioned downstream of PI(3,4)P2 to mediate neuritogenesis and dendritogenesis.	phosphoinositide-3,4-bisphosphate	117-126	actin related protein 2	Homo sapiens	77-81
27859053-3	2017	TAPP KI mice bearing PH domain-inactivating mutations in both TAPP1 and TAPP2 genes, uncoupling them from PI(3,4)P2, exhibit increased BCR-induced activation of the kinase Akt and develop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys.	phosphoinositide-3,4-bisphosphate	106-115	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	Mus musculus	62-67
27859053-3	2017	TAPP KI mice bearing PH domain-inactivating mutations in both TAPP1 and TAPP2 genes, uncoupling them from PI(3,4)P2, exhibit increased BCR-induced activation of the kinase Akt and develop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys.	phosphoinositide-3,4-bisphosphate	106-115	pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2	Mus musculus	72-77
27109423-5	2016	Here, we provide the first report on the role of inositol polyphosphate 4-phosphatase II (INPP4B), a PI(3,4)P2 metabolizing 4-phosphatase in the regulation of callosal axon formation.	phosphoinositide-3,4-bisphosphate	101-110	inositol polyphosphate-4-phosphatase, type II	Mus musculus	90-96
28105255-7	2017	SH2-containing inositol polyphosphate 5-phosphatase (SHIP2), phosphoinositide 3-kinase (PI3K) and their lipid products PtdIns(3,4)P2 and PtdIns(3,4,5)P3, respectively, play an important role in the cell membrane and are key to the establishment of apicobasal polarity and lumen formation.	phosphoinositide-3,4-bisphosphate	119-132	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	61-86
27716613-6	2016	However, unlike PTEN, the reaction product is PI(3,4)P2, which is required for full activation of the downstream protein kinase B (PKB/Akt), suggesting that SHIP2, in contrast to PTEN, could have a tumor initiating role through PKB activation.	phosphoinositide-3,4-bisphosphate	46-55	AKT serine/threonine kinase 1	Homo sapiens	131-138
27716613-6	2016	However, unlike PTEN, the reaction product is PI(3,4)P2, which is required for full activation of the downstream protein kinase B (PKB/Akt), suggesting that SHIP2, in contrast to PTEN, could have a tumor initiating role through PKB activation.	phosphoinositide-3,4-bisphosphate	46-55	inositol polyphosphate phosphatase like 1	Homo sapiens	157-162
27716613-6	2016	However, unlike PTEN, the reaction product is PI(3,4)P2, which is required for full activation of the downstream protein kinase B (PKB/Akt), suggesting that SHIP2, in contrast to PTEN, could have a tumor initiating role through PKB activation.	phosphoinositide-3,4-bisphosphate	46-55	AKT serine/threonine kinase 1	Homo sapiens	131-134
26695371-8	2016	Within chemotaxing B cells, the PI(3,4)P2-binding cytoskeletal regulator lamellipodin (Lpd) was found to colocalize with PI(3,4)P2 on the plasma membrane via its PH domain.	phosphoinositide-3,4-bisphosphate	32-41	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	73-85
26726010-6	2016	Our studies showed that the Lpd-PH domain strongly interacts with PI(3,4)P2 containing liposome without any membrane penetration.	phosphoinositide-3,4-bisphosphate	66-75	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	28-31
26726010-9	2016	Overall, these studies demonstrate an insight into how the Lpd-PH domain regulates cellular signals in a PI(3,4)P2 dependent manner.	phosphoinositide-3,4-bisphosphate	105-114	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	59-62
27222577-1	2016	Voltage-sensing phosphatases (VSPs) are homologs of phosphatase and tensin homolog (PTEN), a phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] 3-phosphatase.	phosphoinositide-3,4-bisphosphate	132-141	phosphatase and tensin homolog B	Danio rerio	84-88
27170292-1	2016	The Src homology 2 containing inositol 5-phosphatase 2 (SHIP2) catalyses the dephosphorylation of the phospholipid phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3) to form PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	177-186	inositol polyphosphate phosphatase like 1	Homo sapiens	4-54
27170292-1	2016	The Src homology 2 containing inositol 5-phosphatase 2 (SHIP2) catalyses the dephosphorylation of the phospholipid phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3) to form PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	177-186	inositol polyphosphate phosphatase like 1	Homo sapiens	56-61
26826186-2	2016	SHIP2 dephosphorylates PI(3,4,5)P3 to form PI(3,4)P2; the latter interacts with specific target proteins (e.g. lamellipodin).	phosphoinositide-3,4-bisphosphate	43-52	inositol polyphosphate phosphatase like 1	Homo sapiens	0-5
26826186-2	2016	SHIP2 dephosphorylates PI(3,4,5)P3 to form PI(3,4)P2; the latter interacts with specific target proteins (e.g. lamellipodin).	phosphoinositide-3,4-bisphosphate	43-52	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	111-123
26695371-8	2016	Within chemotaxing B cells, the PI(3,4)P2-binding cytoskeletal regulator lamellipodin (Lpd) was found to colocalize with PI(3,4)P2 on the plasma membrane via its PH domain.	phosphoinositide-3,4-bisphosphate	32-41	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	87-90
26695371-8	2016	Within chemotaxing B cells, the PI(3,4)P2-binding cytoskeletal regulator lamellipodin (Lpd) was found to colocalize with PI(3,4)P2 on the plasma membrane via its PH domain.	phosphoinositide-3,4-bisphosphate	121-130	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	73-85
26695371-8	2016	Within chemotaxing B cells, the PI(3,4)P2-binding cytoskeletal regulator lamellipodin (Lpd) was found to colocalize with PI(3,4)P2 on the plasma membrane via its PH domain.	phosphoinositide-3,4-bisphosphate	121-130	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	87-90
26695371-11	2016	These results demonstrate that PI(3,4)P2 plays a significant role in cell migration via binding to specific cytoskeletal regulators such as Lpd, and they suggest that impairment of PI(3,4)P2-dependent processes may contribute to the therapeutic efficacy of PI3K inhibitors in B cell malignancies.	phosphoinositide-3,4-bisphosphate	31-40	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	140-143
26695371-11	2016	These results demonstrate that PI(3,4)P2 plays a significant role in cell migration via binding to specific cytoskeletal regulators such as Lpd, and they suggest that impairment of PI(3,4)P2-dependent processes may contribute to the therapeutic efficacy of PI3K inhibitors in B cell malignancies.	phosphoinositide-3,4-bisphosphate	181-190	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	140-143
26022180-5	2015	Signaling through PI(3,4)P2 can be negatively regulated by inositol polyphosphate 4-phosphatases (INPP4A and INPP4B), which selectively degrade PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	18-27	inositol polyphosphate-4-phosphatase type I A	Homo sapiens	98-104
26022180-5	2015	Signaling through PI(3,4)P2 can be negatively regulated by inositol polyphosphate 4-phosphatases (INPP4A and INPP4B), which selectively degrade PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	18-27	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	109-115
26022180-5	2015	Signaling through PI(3,4)P2 can be negatively regulated by inositol polyphosphate 4-phosphatases (INPP4A and INPP4B), which selectively degrade PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	144-153	inositol polyphosphate-4-phosphatase type I A	Homo sapiens	98-104
26022180-5	2015	Signaling through PI(3,4)P2 can be negatively regulated by inositol polyphosphate 4-phosphatases (INPP4A and INPP4B), which selectively degrade PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	144-153	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	109-115
26022180-6	2015	A number of signaling proteins that specifically bind to PI(3,4)P2 have been characterized, including the tandem PH domain-containing proteins (TAPP1 and TAPP2) and lamellipodin/RAPH1.	phosphoinositide-3,4-bisphosphate	57-66	pleckstrin homology domain containing A1	Homo sapiens	144-149
26022180-6	2015	A number of signaling proteins that specifically bind to PI(3,4)P2 have been characterized, including the tandem PH domain-containing proteins (TAPP1 and TAPP2) and lamellipodin/RAPH1.	phosphoinositide-3,4-bisphosphate	57-66	pleckstrin homology domain containing A2	Homo sapiens	154-159
26022180-6	2015	A number of signaling proteins that specifically bind to PI(3,4)P2 have been characterized, including the tandem PH domain-containing proteins (TAPP1 and TAPP2) and lamellipodin/RAPH1.	phosphoinositide-3,4-bisphosphate	57-66	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	165-177
26022180-6	2015	A number of signaling proteins that specifically bind to PI(3,4)P2 have been characterized, including the tandem PH domain-containing proteins (TAPP1 and TAPP2) and lamellipodin/RAPH1.	phosphoinositide-3,4-bisphosphate	57-66	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	178-183
26022180-9	2015	A summary of available data addressing the relative contribution of PI(3,4)P2 versus PIP3 in regulation of Akt is provided to highlight the potential independent role of PI(3,4)P2 in regulating some PIP3-binding proteins.	phosphoinositide-3,4-bisphosphate	68-77	AKT serine/threonine kinase 1	Homo sapiens	107-110
26022180-9	2015	A summary of available data addressing the relative contribution of PI(3,4)P2 versus PIP3 in regulation of Akt is provided to highlight the potential independent role of PI(3,4)P2 in regulating some PIP3-binding proteins.	phosphoinositide-3,4-bisphosphate	170-179	AKT serine/threonine kinase 1	Homo sapiens	107-110
26115715-12	2015	PtdIns(3,4)P2 is absent in yeast, cells and mainly produced by PtdIns4P phosphorylation in human cells; PtdIns(3,4)P2 is localised in the plasma membrane and plays an important role as a second messenger by recruiting specific protein kinases (Akt and PDK1).	phosphoinositide-3,4-bisphosphate	0-13	pyruvate dehydrogenase kinase 1	Homo sapiens	252-256
25613364-2	2015	Profilin1, an actin and phosphoinositide binding protein, is downregulated in several adenocarcinomas and it is been shown that its depletion enhances invasiveness and motility of breast cancer cells by increasing PI(3,4)P2 levels at the leading edge.	phosphoinositide-3,4-bisphosphate	214-223	profilin 1	Homo sapiens	0-9
25613364-5	2015	(2013a), has shown that the binding of the protein Tks5 with PI(3,4)P2 confers stability to the invadopodium precursor causing it to mature into a degradation-competent structure.	phosphoinositide-3,4-bisphosphate	61-70	SH3 and PX domains 2A	Homo sapiens	51-55
25613364-6	2015	We found that loss of profilin1 expression increases the levels of PI(3,4)P2 at the invadopodium and as a result, enhances recruitment of the interacting adaptor Tks5.	phosphoinositide-3,4-bisphosphate	67-76	profilin 1	Homo sapiens	22-31
25613364-8	2015	Our results indicate that profilin1 acts as a molecular regulator of the levels of PI(3,4)P2 and Tks5 recruitment in invadopodia to control the invasion efficiency of invadopodia.	phosphoinositide-3,4-bisphosphate	83-92	profilin 1	Homo sapiens	26-35
26115715-12	2015	PtdIns(3,4)P2 is absent in yeast, cells and mainly produced by PtdIns4P phosphorylation in human cells; PtdIns(3,4)P2 is localised in the plasma membrane and plays an important role as a second messenger by recruiting specific protein kinases (Akt and PDK1).	phosphoinositide-3,4-bisphosphate	104-117	pyruvate dehydrogenase kinase 1	Homo sapiens	252-256
26843905-5	2014	Co-expression of chick PTEN suppressed such morphological change, suggesting that VSP regulates cell shape by increasing PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	121-130	phosphatase and tensin homolog	Gallus gallus	23-27
25635986-2	2015	Src homology 2-containing 5"-inositol phosphatase 2 (SHIP2) is a lipid phosphatase that hydrolyzes PI3-kinase product PI(3,4,5)P3 to PI(3,4)P2, which contributes to the negative regulation of insulin signaling both in vitro and in vivo.	phosphoinositide-3,4-bisphosphate	133-142	inositol polyphosphate phosphatase like 1	Homo sapiens	0-51
25635986-2	2015	Src homology 2-containing 5"-inositol phosphatase 2 (SHIP2) is a lipid phosphatase that hydrolyzes PI3-kinase product PI(3,4,5)P3 to PI(3,4)P2, which contributes to the negative regulation of insulin signaling both in vitro and in vivo.	phosphoinositide-3,4-bisphosphate	133-142	inositol polyphosphate phosphatase like 1	Homo sapiens	53-58
25635986-2	2015	Src homology 2-containing 5"-inositol phosphatase 2 (SHIP2) is a lipid phosphatase that hydrolyzes PI3-kinase product PI(3,4,5)P3 to PI(3,4)P2, which contributes to the negative regulation of insulin signaling both in vitro and in vivo.	phosphoinositide-3,4-bisphosphate	133-142	insulin	Homo sapiens	192-199
23823722-5	2013	Here we show that formation of phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) by class II phosphatidylinositol-3-kinase C2alpha (PI(3)K C2alpha) spatiotemporally controls clathrin-mediated endocytosis.	phosphoinositide-3,4-bisphosphate	70-79	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	93-146
24591580-5	2014	INPP4B, which dephosphorylates PI(3,4)P2 to PI(3)P, was also found to be essential for macropinocytosis.	phosphoinositide-3,4-bisphosphate	31-40	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	0-6
24206842-6	2013	SHIP2, a 5"-inositol phosphatase, localizes at the invadopodium core and regulates PI(3,4)P2 levels locally at the invadopodium.	phosphoinositide-3,4-bisphosphate	83-92	inositol polyphosphate phosphatase like 1	Homo sapiens	0-5
24206842-7	2013	The timing of SHIP2 arrival at the invadopodium precursor coincides with the onset of PI(3,4)P2 accumulation.	phosphoinositide-3,4-bisphosphate	86-95	inositol polyphosphate phosphatase like 1	Homo sapiens	14-19
23990921-5	2013	However, depletion of PI(3,4) P2/PI(3-5) P3 by expression of the phosphoinositide 3-phosphatase PTEN inhibits Akt activation during Salmonella invasion.	phosphoinositide-3,4-bisphosphate	22-32	phosphatase and tensin homolog	Homo sapiens	96-100
23990921-5	2013	However, depletion of PI(3,4) P2/PI(3-5) P3 by expression of the phosphoinositide 3-phosphatase PTEN inhibits Akt activation during Salmonella invasion.	phosphoinositide-3,4-bisphosphate	22-32	AKT serine/threonine kinase 1	Homo sapiens	110-113
23990921-6	2013	Therefore, production of PI(3,4) P2/PI(3-5) P3 appears to be a necessary event for Akt activation by SopB and suggests that non-canonical kinases mediate production of these phosphoinositides during Salmonella infection.	phosphoinositide-3,4-bisphosphate	25-35	AKT serine/threonine kinase 1	Homo sapiens	83-86
24038012-8	2014	Coexpression of PTEN that dephosphorylates PI(3,4)P2 suppressed this effect by Gg-VSP, indicating that the increase of PI(3,4)P2 leads to changes of cell shape.	phosphoinositide-3,4-bisphosphate	43-52	phosphatase and tensin homolog	Homo sapiens	16-20
24038012-8	2014	Coexpression of PTEN that dephosphorylates PI(3,4)P2 suppressed this effect by Gg-VSP, indicating that the increase of PI(3,4)P2 leads to changes of cell shape.	phosphoinositide-3,4-bisphosphate	119-128	phosphatase and tensin homolog	Homo sapiens	16-20
24038012-9	2014	In addition, visualization of PI(3,4)P2 with the fluorescent protein fused with the TAPP1-derived pleckstrin homology (PH) domain suggested that Gg-VSP influenced the distribution of PI(3,4)P2 .	phosphoinositide-3,4-bisphosphate	30-39	pleckstrin homology domain containing A1	Homo sapiens	84-89
24038012-9	2014	In addition, visualization of PI(3,4)P2 with the fluorescent protein fused with the TAPP1-derived pleckstrin homology (PH) domain suggested that Gg-VSP influenced the distribution of PI(3,4)P2 .	phosphoinositide-3,4-bisphosphate	183-192	pleckstrin homology domain containing A1	Homo sapiens	84-89
24091101-2	2014	The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	161-170	inositol polyphosphate-5-phosphatase D	Homo sapiens	50-55
24091101-2	2014	The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	161-170	inositol polyphosphate phosphatase like 1	Homo sapiens	60-65
24091101-6	2014	This could be linked to the relative importance of PI(3,4)P2 (a product of SHIP2 phosphatase activity) which is also controlled by the PI 4-phosphatase and tumor suppressor INPP4B.	phosphoinositide-3,4-bisphosphate	51-60	inositol polyphosphate phosphatase like 1	Homo sapiens	75-80
24091101-6	2014	This could be linked to the relative importance of PI(3,4)P2 (a product of SHIP2 phosphatase activity) which is also controlled by the PI 4-phosphatase and tumor suppressor INPP4B.	phosphoinositide-3,4-bisphosphate	51-60	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	173-179
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	139-148	inositol polyphosphate-5-phosphatase D	Homo sapiens	47-58
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	139-148	inositol polyphosphate-5-phosphatase D	Homo sapiens	164-171
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	139-148	inositol polyphosphate-4-phosphatase type I A	Homo sapiens	181-187
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	211-220	inositol polyphosphate-5-phosphatase D	Homo sapiens	47-58
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	211-220	inositol polyphosphate-5-phosphatase D	Homo sapiens	164-171
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	211-220	inositol polyphosphate-4-phosphatase type I A	Homo sapiens	181-187
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	211-220	inositol polyphosphate-5-phosphatase D	Homo sapiens	47-58
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	211-220	inositol polyphosphate-5-phosphatase D	Homo sapiens	164-171
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	211-220	inositol polyphosphate-4-phosphatase type I A	Homo sapiens	181-187
23823722-7	2013	Timed formation of PI(3,4)P2 by PI(3)K C2alpha is required for selective enrichment of the BAR domain protein SNX9 at late-stage endocytic intermediates.	phosphoinositide-3,4-bisphosphate	19-28	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	32-46
23823722-7	2013	Timed formation of PI(3,4)P2 by PI(3)K C2alpha is required for selective enrichment of the BAR domain protein SNX9 at late-stage endocytic intermediates.	phosphoinositide-3,4-bisphosphate	19-28	sorting nexin 9	Homo sapiens	110-114
23551094-2	2013	SHIP1 removes the 5"-phosphate from the product of PI3K, PI(3,4,5)P3, to generate PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	82-91	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-5
23466492-5	2013	Binding of phosphoinositides PI(4,5)P2, PI(3,4,5)P3 and PI(3,4)P2 to alpha-actinin-4, as well as binding of alpha-actinin-4 to actin filaments all inhibit m-calpain cleavage of ACTN4 between tyrosine 13 and glycine 14.	phosphoinositide-3,4-bisphosphate	56-65	actinin alpha 4	Homo sapiens	69-84
23121445-2	2013	BACKGROUND: The SH2-containing inositol-5"-phosphatase 1 (SHIP1) metabolizes PI(3,4,5)P3 to PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	92-101	inositol polyphosphate-5-phosphatase D	Homo sapiens	16-56
23121445-2	2013	BACKGROUND: The SH2-containing inositol-5"-phosphatase 1 (SHIP1) metabolizes PI(3,4,5)P3 to PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	92-101	inositol polyphosphate-5-phosphatase D	Homo sapiens	58-63
23460911-2	2013	Tandem PH domain-containing proteins TAPP1 and TAPP2 are adaptor proteins that specifically bind to phosphatidylinositol-3,4-bisphosphate, or PI(3,4)P2, a product of phosphoinositide 3-kinases (PI3K).	phosphoinositide-3,4-bisphosphate	142-151	pleckstrin homology domain containing A1	Homo sapiens	37-42
23460911-2	2013	Tandem PH domain-containing proteins TAPP1 and TAPP2 are adaptor proteins that specifically bind to phosphatidylinositol-3,4-bisphosphate, or PI(3,4)P2, a product of phosphoinositide 3-kinases (PI3K).	phosphoinositide-3,4-bisphosphate	142-151	pleckstrin homology domain containing A2	Homo sapiens	47-52
22682687-1	2012	Skeletal muscle and kidney-enriched inositol phosphatase (SKIP) was identified as a 5"-inositol phosphatase that hydrolyzes phosphatidylinositol (3,4,5)-triphosphate (PI(3,4,5)P3) to PI(3,4)P2 and negatively regulates insulin-induced phosphatidylinositol 3-kinase signaling in skeletal muscle.	phosphoinositide-3,4-bisphosphate	183-192	inositol polyphosphate 5-phosphatase K	Mus musculus	0-56
22777911-1	2012	TAPP1 and TAPP2 (where TAPP is tandem PH domain containing protein) are dual PH domain adaptors that selectively bind PI(3,4)P2 (phosphatidylinositol (3,4)-bisphosphate).	phosphoinositide-3,4-bisphosphate	118-127	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	Mus musculus	0-5
22777911-1	2012	TAPP1 and TAPP2 (where TAPP is tandem PH domain containing protein) are dual PH domain adaptors that selectively bind PI(3,4)P2 (phosphatidylinositol (3,4)-bisphosphate).	phosphoinositide-3,4-bisphosphate	118-127	pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2	Mus musculus	10-15
22777911-2	2012	PI(3,4)P2 is a lipid messenger generated by phosphoinositide 3-kinase (PI3K) and SHIP, both of which are critical regulators of B-cell activation.	phosphoinositide-3,4-bisphosphate	0-9	inositol polyphosphate-5-phosphatase D	Mus musculus	81-85
22493288-0	2012	Atypical membrane-embedded phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)-binding site on p47(phox) Phox homology (PX) domain revealed by NMR.	phosphoinositide-3,4-bisphosphate	66-75	pleckstrin	Homo sapiens	93-96
22915108-6	2012	Lpd binds to phosphatidylinositol (3,4)-bisphosphate [PI(3,4)P2] and recruits Ena/VASP, which promotes the assembly of actin filaments, to the plasma membranes.	phosphoinositide-3,4-bisphosphate	54-63	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	0-3
22493288-4	2012	The identified PI(3,4)P(2)-binding site, which includes the residues of helices alpha1 and alpha1" and the following loop up to the distorted left-handed PP(II) helix, is located at a unique position, as compared with the phosphoinositide-binding sites of all other PX domains characterized thus far.	phosphoinositide-3,4-bisphosphate	15-26	adrenoceptor alpha 1D	Homo sapiens	80-98
22121510-2	2012	In this pathway, PKB is recruited to the plasma membrane by direct interaction of its pleckstrin homology (PH) domain with the inositol phosphate head-group of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] or phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P(2)].	phosphoinositide-3,4-bisphosphate	263-275	protein tyrosine kinase 2 beta	Homo sapiens	17-20
22033675-2	2012	It has long been thought that the lipid phosphatases SH2 domain-containing inositol-5"-phosphatase 1 (SHIP1) and SHIP2 act as tumor suppressors by counteracting with the survival signal induced by this pathway through hydrolysis or PtdIns(3,4,5)P(3) to PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	253-265	inositol polyphosphate-5-phosphatase D	Mus musculus	53-100
22033675-2	2012	It has long been thought that the lipid phosphatases SH2 domain-containing inositol-5"-phosphatase 1 (SHIP1) and SHIP2 act as tumor suppressors by counteracting with the survival signal induced by this pathway through hydrolysis or PtdIns(3,4,5)P(3) to PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	253-265	inositol polyphosphate-5-phosphatase D	Mus musculus	102-107
22033675-2	2012	It has long been thought that the lipid phosphatases SH2 domain-containing inositol-5"-phosphatase 1 (SHIP1) and SHIP2 act as tumor suppressors by counteracting with the survival signal induced by this pathway through hydrolysis or PtdIns(3,4,5)P(3) to PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	253-265	inositol polyphosphate phosphatase-like 1	Mus musculus	113-118
22033675-8	2012	Interestingly, in SHIP2-expressing breast cancer cells that lack SHIP1 expression, pan-SHIP1/2 inhibition also reduces viable cell numbers, which can be rescued by addition of exogenous PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	186-198	inositol polyphosphate phosphatase-like 1	Mus musculus	18-23
22033675-8	2012	Interestingly, in SHIP2-expressing breast cancer cells that lack SHIP1 expression, pan-SHIP1/2 inhibition also reduces viable cell numbers, which can be rescued by addition of exogenous PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	186-198	inositol polyphosphate-5-phosphatase D	Mus musculus	87-92
20956018-3	2010	The PH domain adaptor protein Bam32/DAPP1 binds specifically to the D3 phosphoinositides PI(3,4,5)P3 and PI(3,4)P2 (the substrate and product of SHIP respectively).	phosphoinositide-3,4-bisphosphate	105-114	dual adaptor for phosphotyrosine and 3-phosphoinositides 1	Mus musculus	30-35
21263009-4	2011	A secondary purification of these proteins, optimized using tandem pleckstrin homology domain containing protein-1 (TAPP-1), an established PtdIns(3,4)P(2) selective ligand, yields a fraction enriched in proteins of potentially similar lipid binding character that are identified by liquid chromatography-tandem MS. Thirdly, this approach is coupled to stable isotope labeling with amino acids in cell culture using differential isotope labeling of cells stimulated in the absence and presence of the PI 3-kinase inhibitor wortmannin.	phosphoinositide-3,4-bisphosphate	140-152	pleckstrin homology domain containing A1	Homo sapiens	116-122
21864294-5	2012	In addition, AtPTEN2a actively dephosphorylates in vitro the 3" phosphate group of PI3P (phosphatidylinositol 3-phosphate), PI(3,4)P2 (phosphatidylinositol 3,4-bisphosphate) and PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate).	phosphoinositide-3,4-bisphosphate	124-133	PTEN 2	Arabidopsis thaliana	13-20
22403078-9	2012	The inositol polyphosphate 4-phosphatases, INPP4A and INPP4B degrade PtdIns(3,4)P(2) to PtdIns(3)P and regulate neuroexcitatory cell death, or act as a tumor suppressor in breast cancer respectively.	phosphoinositide-3,4-bisphosphate	69-81	inositol polyphosphate-4-phosphatase type I A	Homo sapiens	43-49
22403078-9	2012	The inositol polyphosphate 4-phosphatases, INPP4A and INPP4B degrade PtdIns(3,4)P(2) to PtdIns(3)P and regulate neuroexcitatory cell death, or act as a tumor suppressor in breast cancer respectively.	phosphoinositide-3,4-bisphosphate	69-81	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	54-60
21628641-4	2011	PSP binds PtdIns(3,4)P(2), 10-fold greater than PtdIns(3,5)P(2) or PtdIns(4)P, and does not bind PtdIns(3)P or PtdIns(5)P.	phosphoinositide-3,4-bisphosphate	10-22	BPI fold containing family A, member 2	Rattus norvegicus	0-3
21628641-5	2011	Human PSP synthesized in vitro also binds PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	42-54	BPI fold containing family A member 2	Homo sapiens	6-9
21628641-6	2011	Bacterially expressed rat PSP binds PtdIns(3,4)P(2) with a K(d) of 2.4 x 10(-11) M. Other major secretory proteins (amylase, proline-rich protein) are not bound to isolated granule membranes and do not bind phosphatidylinositol phosphates.	phosphoinositide-3,4-bisphosphate	36-48	BPI fold containing family A, member 2	Rattus norvegicus	26-29
21609323-5	2011	The binding affinity of PIPs to the EWI2 tail, however, is not solely based on charge because PtdIns5P, PtdIns4P and PtdIns3P have a higher affinity to EWI2 than PtdIns(3,5)P(2) and PtdIns(3,4)P(2) do.	phosphoinositide-3,4-bisphosphate	182-194	immunoglobulin superfamily member 8	Homo sapiens	36-40
21609323-5	2011	The binding affinity of PIPs to the EWI2 tail, however, is not solely based on charge because PtdIns5P, PtdIns4P and PtdIns3P have a higher affinity to EWI2 than PtdIns(3,5)P(2) and PtdIns(3,4)P(2) do.	phosphoinositide-3,4-bisphosphate	182-194	immunoglobulin superfamily member 8	Homo sapiens	152-156
21204784-4	2011	Previously, we identified two related adaptor proteins termed TAPP [tandem PH (pleckstrin homology)-domain-containing protein] 1 and TAPP2 that specifically bind to PtdIns(3,4)P(2) through their C-terminal PH domain.	phosphoinositide-3,4-bisphosphate	165-177	pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2	Mus musculus	133-138
21204784-9	2011	These observations provide the first genetic evidence to support the notion that binding of TAPP1 and TAPP2 adap-tors to PtdIns(3,4)P(2) function as negative regulators of the insulin and PI3K signalling pathways.	phosphoinositide-3,4-bisphosphate	121-133	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	Mus musculus	92-97
21204784-9	2011	These observations provide the first genetic evidence to support the notion that binding of TAPP1 and TAPP2 adap-tors to PtdIns(3,4)P(2) function as negative regulators of the insulin and PI3K signalling pathways.	phosphoinositide-3,4-bisphosphate	121-133	pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2	Mus musculus	102-107
20336382-1	2011	Skeletal muscle and kidney enriched inositol phosphatase (SKIP) was identified as a 5"-inositol phosphatase that hydrolyzes PI(3,4,5)P3 to PI(3,4)P2 that negatively regulates insulin-induced phosphatidylinositol 3-kinase signaling in skeletal muscle.	phosphoinositide-3,4-bisphosphate	139-148	inositol polyphosphate-5-phosphatase K	Sus scrofa	0-56
21115820-0	2010	Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells.	phosphoinositide-3,4-bisphosphate	20-29	profilin 1	Homo sapiens	0-9
20956018-3	2010	The PH domain adaptor protein Bam32/DAPP1 binds specifically to the D3 phosphoinositides PI(3,4,5)P3 and PI(3,4)P2 (the substrate and product of SHIP respectively).	phosphoinositide-3,4-bisphosphate	105-114	dual adaptor for phosphotyrosine and 3-phosphoinositides 1	Mus musculus	36-41
20956018-3	2010	The PH domain adaptor protein Bam32/DAPP1 binds specifically to the D3 phosphoinositides PI(3,4,5)P3 and PI(3,4)P2 (the substrate and product of SHIP respectively).	phosphoinositide-3,4-bisphosphate	105-114	inositol polyphosphate-5-phosphatase D	Mus musculus	145-149
20872961-2	2010	In this pathway, PTEN acts as a phosphoinositide phosphatase, which terminates PI3K-propagated signaling by dephosphorylating PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3).	phosphoinositide-3,4-bisphosphate	126-138	phosphatase and tensin homolog	Homo sapiens	17-21
20114020-2	2010	A recent study now shows that two additional tyrosines within Tir recruit the inositol phosphatase SHIP2 to generate a PI(3,4)P2-enriched membrane platform that stabilizes pedestal assembly.	phosphoinositide-3,4-bisphosphate	119-128	Tir	Escherichia coli	62-65
20061304-10	2010	We examined the capacity for binding to phosphatidylinositol phosphates (PtdInsPs), and found that PCaP2 interacts strongly with PtdIns(3,5)P(2), PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3), and weakly with PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	201-213	microtubule-associated protein 18	Arabidopsis thaliana	99-104
20463662-0	2010	The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.	phosphoinositide-3,4-bisphosphate	4-16	inositol polyphosphate-4-phosphatase, type I	Mus musculus	32-38
20463662-4	2010	Here we show that inositol polyphosphate phosphatase 4A (INPP4A), a PtdIns(3,4)P(2) phosphatase, is a suppressor of glutamate excitotoxicity in the central nervous system.	phosphoinositide-3,4-bisphosphate	68-80	inositol polyphosphate-4-phosphatase, type I	Mus musculus	18-55
20463662-4	2010	Here we show that inositol polyphosphate phosphatase 4A (INPP4A), a PtdIns(3,4)P(2) phosphatase, is a suppressor of glutamate excitotoxicity in the central nervous system.	phosphoinositide-3,4-bisphosphate	68-80	inositol polyphosphate-4-phosphatase, type I	Mus musculus	57-63
19325558-2	2009	PI(3)K-generated signals, PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2), direct Akt plasma membrane engagement.	phosphoinositide-3,4-bisphosphate	48-60	thymoma viral proto-oncogene 1	Mus musculus	72-75
19465920-7	2009	Furthermore, we found that PtdIns(3,5)P(2) and PtdIns(3,4)P(2) bound to, and directly activated, the Ca(2+) release channel (ryanodine receptor 1, RyR1) of the sarcoplasmic reticulum.	phosphoinositide-3,4-bisphosphate	47-59	ryanodine receptor 1, skeletal muscle	Mus musculus	101-145
19465920-7	2009	Furthermore, we found that PtdIns(3,5)P(2) and PtdIns(3,4)P(2) bound to, and directly activated, the Ca(2+) release channel (ryanodine receptor 1, RyR1) of the sarcoplasmic reticulum.	phosphoinositide-3,4-bisphosphate	47-59	ryanodine receptor 1, skeletal muscle	Mus musculus	147-151
19942142-3	2009	The membrane-permeant PtdIns(3,4,5,6)P(4) derivative activated pathways downstream of phosphatidylinositol 3-kinase (PI3K), including protein kinase B, p70S6K, mitogen-activated protein kinase, and protein kinase C, more potently than similar membrane-permeant PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2) derivatives in the absence of receptor stimulation.	phosphoinositide-3,4-bisphosphate	283-295	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	86-115
19325558-4	2009	PtdIns(3,4)P(2) is degraded by inositol polyphosphate 4-phosphatase-1 (4-ptase-1) forming PtdIns(3)P; however, the role of 4-ptase-1 in regulating the activation and function of Akt is unclear.	phosphoinositide-3,4-bisphosphate	0-12	thymoma viral proto-oncogene 1	Mus musculus	178-181
18492765-2	2008	Insulin-stimulated formation of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3); and in some cases, of its catabolite PtdIns(3,4)P(2)] plays a pivotal role in this process.	phosphoinositide-3,4-bisphosphate	130-142	insulin	Homo sapiens	0-7
18794881-4	2008	Coordinating PTEN activity with alternative mechanisms of PtdInsP(3) metabolism, by the tightly regulated SHIP 5-phoshatases, synthesizing the independent second messenger PtdIns(3,4)P(2), may also be important for cellular polarization in some cell types.	phosphoinositide-3,4-bisphosphate	172-184	phosphatase and tensin homolog	Mus musculus	13-17
18672905-0	2008	Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation.	phosphoinositide-3,4-bisphosphate	52-61	neutrophil cytosolic factor 1	Homo sapiens	35-42
18672905-3	2008	Our manipulation of p47 (phox) by mutation and amino acid deletion shows that the linker region between the PX and N-terminal SH3 domain plays a role in blocking the binding of the phosphoinositide 3,4-bisphosphate [PI(3,4)P2], a lipid second messenger generated upon neutrophil activation.	phosphoinositide-3,4-bisphosphate	181-214	pleckstrin	Homo sapiens	20-23
18672905-3	2008	Our manipulation of p47 (phox) by mutation and amino acid deletion shows that the linker region between the PX and N-terminal SH3 domain plays a role in blocking the binding of the phosphoinositide 3,4-bisphosphate [PI(3,4)P2], a lipid second messenger generated upon neutrophil activation.	phosphoinositide-3,4-bisphosphate	216-225	pleckstrin	Homo sapiens	20-23
17893321-1	2007	Phosphoinositide 3-kinase (PI3K) activation and synthesis of phosphatidylinositol-3,4-bisphosphate (PI-3,4-P2) and phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) lipids mediate growth factor signaling that leads to cell proliferation, migration, and survival.	phosphoinositide-3,4-bisphosphate	100-109	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-25
17314030-7	2007	Since it was shown previously that Arap3 has a higher affinity for PI(3,4,5,)P3 than for PI(3,4)P2, we propose that the SAM domain of Arap3 can function to recruit a negative regulator of PI3K signaling into the effector complex.	phosphoinositide-3,4-bisphosphate	89-98	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	Homo sapiens	35-40
17314030-7	2007	Since it was shown previously that Arap3 has a higher affinity for PI(3,4,5,)P3 than for PI(3,4)P2, we propose that the SAM domain of Arap3 can function to recruit a negative regulator of PI3K signaling into the effector complex.	phosphoinositide-3,4-bisphosphate	89-98	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	Homo sapiens	134-139
17219406-2	2007	SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) converts PI(3,4,5)P3 into PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	81-90	inositol polyphosphate phosphatase like 1	Homo sapiens	0-46
17219406-2	2007	SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) converts PI(3,4,5)P3 into PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	81-90	inositol polyphosphate phosphatase like 1	Homo sapiens	48-53
17215104-5	2007	Peroxide was found to induce dose-dependant membrane recruitment of the PI(3,4)P2-binding PH domain proteins Bam32, TAPP2 and Akt/PKB but not the PIP3-binding PH domain of Btk.	phosphoinositide-3,4-bisphosphate	72-81	dual adaptor of phosphotyrosine and 3-phosphoinositides 1	Homo sapiens	109-114
17215104-5	2007	Peroxide was found to induce dose-dependant membrane recruitment of the PI(3,4)P2-binding PH domain proteins Bam32, TAPP2 and Akt/PKB but not the PIP3-binding PH domain of Btk.	phosphoinositide-3,4-bisphosphate	72-81	pleckstrin homology domain containing A2	Homo sapiens	116-121
17215104-5	2007	Peroxide was found to induce dose-dependant membrane recruitment of the PI(3,4)P2-binding PH domain proteins Bam32, TAPP2 and Akt/PKB but not the PIP3-binding PH domain of Btk.	phosphoinositide-3,4-bisphosphate	72-81	AKT serine/threonine kinase 1	Homo sapiens	126-133
15469845-5	2004	Lpd contains a PH domain that binds specifically to PI(3,4)P2, an asymmetrically localized signal in chemotactic cells.	phosphoinositide-3,4-bisphosphate	52-61	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	0-3
17173040-3	2007	Our analysis of mammalian neutrophil migration towards ligands such as fMLP shows that, although PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) accumulate in a PI(3)Kgamma-dependent fashion at the up-gradient leading-edge, this signal is not required for efficient gradient-sensing and gradient-biased movement.	phosphoinositide-3,4-bisphosphate	97-109	formyl peptide receptor 1	Homo sapiens	71-75
16842239-10	2006	Stabilization of the phox-associated proton channel in a highly voltage-sensitive conformation does not appear to involve phosphorylation but ATP binding, and requires not only ATP and GTP[S] but also PI(3,4)P2, a protein known to anchor the cytosolic phox subunit p47(phox) to the plasma membrane.	phosphoinositide-3,4-bisphosphate	201-210	pleckstrin	Homo sapiens	21-25
16842239-10	2006	Stabilization of the phox-associated proton channel in a highly voltage-sensitive conformation does not appear to involve phosphorylation but ATP binding, and requires not only ATP and GTP[S] but also PI(3,4)P2, a protein known to anchor the cytosolic phox subunit p47(phox) to the plasma membrane.	phosphoinositide-3,4-bisphosphate	201-210	pleckstrin	Homo sapiens	252-256
16842239-10	2006	Stabilization of the phox-associated proton channel in a highly voltage-sensitive conformation does not appear to involve phosphorylation but ATP binding, and requires not only ATP and GTP[S] but also PI(3,4)P2, a protein known to anchor the cytosolic phox subunit p47(phox) to the plasma membrane.	phosphoinositide-3,4-bisphosphate	201-210	pleckstrin	Homo sapiens	265-274
17119157-3	2006	Class I(A) phosphatidylinositol 3-kinase (PI3K), which is composed of a p85 (regulatory) and p110 (catalytic) subunits, is the enzyme generating PI(3,4)P2 and PI(3,4,5)P3 following GFR stimulation.	phosphoinositide-3,4-bisphosphate	145-154	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	11-40
17119157-3	2006	Class I(A) phosphatidylinositol 3-kinase (PI3K), which is composed of a p85 (regulatory) and p110 (catalytic) subunits, is the enzyme generating PI(3,4)P2 and PI(3,4,5)P3 following GFR stimulation.	phosphoinositide-3,4-bisphosphate	145-154	endogenous retrovirus group K member 15	Homo sapiens	93-97
17119157-3	2006	Class I(A) phosphatidylinositol 3-kinase (PI3K), which is composed of a p85 (regulatory) and p110 (catalytic) subunits, is the enzyme generating PI(3,4)P2 and PI(3,4,5)P3 following GFR stimulation.	phosphoinositide-3,4-bisphosphate	145-154	Rap guanine nucleotide exchange factor 5	Homo sapiens	181-184
17119157-5	2006	Examination of frequent genetic alterations in human cancer showed that PTEN (phosphatase with tensin homology on chromosome 10) is the major enzyme that decreases PI(3,4)P2 and PI(3,4,5)P3 cell content.	phosphoinositide-3,4-bisphosphate	164-173	phosphatase and tensin homolog	Homo sapiens	72-76
16418223-4	2006	Here we report that in neutrophilic HL-60 cells expressing PH-Akt-GFP, binding of iC3b-coated zymosan particles (2 microm in diameter) via beta2 integrin induces an incomplete phagocytic cup to form before either PtdIns(3,4,5)P(3) or phosphatidylinositol (3,4) bisphosphate [PtdIns(3,4)P(2)] production or Ca(2+) signalling.	phosphoinositide-3,4-bisphosphate	275-287	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	139-144
17371235-7	2007	We suggest that concomitant inhibition of cysteine-dependent phosphatases, such as PTEN, with activation of SHIP2 functions as a metabolic switch to regulate independently the relative levels of PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	217-229	phosphatase and tensin homolog	Mus musculus	83-87
17371235-7	2007	We suggest that concomitant inhibition of cysteine-dependent phosphatases, such as PTEN, with activation of SHIP2 functions as a metabolic switch to regulate independently the relative levels of PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	217-229	inositol polyphosphate phosphatase-like 1	Mus musculus	108-113
16842970-5	2007	However, other enzymes in addition to PTEN can antagonise PI3K, including SHIP2, which degrades PIP3 to phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2).	phosphoinositide-3,4-bisphosphate	143-152	phosphatase and tensin homolog	Homo sapiens	38-42
16842970-5	2007	However, other enzymes in addition to PTEN can antagonise PI3K, including SHIP2, which degrades PIP3 to phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2).	phosphoinositide-3,4-bisphosphate	143-152	inositol polyphosphate phosphatase like 1	Homo sapiens	74-79
16824732-1	2006	The SH2 domain containing inositol 5-phosphatase 2 (SHIP2) catalyzes the dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P(2)) and participates in the insulin signalling pathway in vivo.	phosphoinositide-3,4-bisphosphate	197-209	inositol polyphosphate phosphatase like 1	Homo sapiens	4-50
16824732-1	2006	The SH2 domain containing inositol 5-phosphatase 2 (SHIP2) catalyzes the dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P(2)) and participates in the insulin signalling pathway in vivo.	phosphoinositide-3,4-bisphosphate	197-209	inositol polyphosphate phosphatase like 1	Homo sapiens	52-57
16143324-2	2005	The pleckstrin homology (PH) domain of ORP3 binds the phosphoinositide-3-kinase (PI3K) products, PI(3,4)P2 and PI(3,4,5)P3.	phosphoinositide-3,4-bisphosphate	97-106	oxysterol binding protein like 3	Homo sapiens	39-43
16214892-8	2005	Furthermore, simultaneous imaging of a plasma membrane-targeted PI indicator and a nuclear-targeted Akt activity reporter revealed a gradual and sustained accumulation of Akt activity in the nucleus after rapid and transient production of PIP3 and PI(3,4)P2 at plasma membrane in the same cell.	phosphoinositide-3,4-bisphosphate	248-257	thymoma viral proto-oncogene 1	Mus musculus	171-174
15687335-1	2005	Src homology 2-containing 5"-inositol phosphatase 2 (SHIP2) is known to be one of lipid phosphatases converting PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling with the fundamental impact on the state of insulin resistance.	phosphoinositide-3,4-bisphosphate	127-136	inositol polyphosphate phosphatase like 1	Homo sapiens	0-51
15687335-1	2005	Src homology 2-containing 5"-inositol phosphatase 2 (SHIP2) is known to be one of lipid phosphatases converting PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling with the fundamental impact on the state of insulin resistance.	phosphoinositide-3,4-bisphosphate	127-136	inositol polyphosphate phosphatase like 1	Homo sapiens	53-58
15687335-1	2005	Src homology 2-containing 5"-inositol phosphatase 2 (SHIP2) is known to be one of lipid phosphatases converting PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling with the fundamental impact on the state of insulin resistance.	phosphoinositide-3,4-bisphosphate	127-136	insulin	Homo sapiens	167-174
15687335-1	2005	Src homology 2-containing 5"-inositol phosphatase 2 (SHIP2) is known to be one of lipid phosphatases converting PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling with the fundamental impact on the state of insulin resistance.	phosphoinositide-3,4-bisphosphate	127-136	insulin	Homo sapiens	229-236
15199069-10	2004	Interestingly, the presence of RhoG but not Rac or a C-terminal-truncated RhoG mutant allows TrioN to bind PtdIns(3,4)P(2) with a micromolar affinity constant.	phosphoinositide-3,4-bisphosphate	107-119	ras homolog family member G	Homo sapiens	31-35
15199069-10	2004	Interestingly, the presence of RhoG but not Rac or a C-terminal-truncated RhoG mutant allows TrioN to bind PtdIns(3,4)P(2) with a micromolar affinity constant.	phosphoinositide-3,4-bisphosphate	107-119	ras homolog family member G	Homo sapiens	74-78
12145149-1	2002	SH-2-containing inositol 5"-phosphatase 2 (SHIP-2) is a physiologically important lipid phosphatase that functions to hydrolyze phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling.	phosphoinositide-3,4-bisphosphate	186-195	inositol polyphosphate phosphatase-like 1	Mus musculus	0-41
15135055-1	2004	SH2 domain containing inositol polyphosphate 5-phosphatase (SHIP2) dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) into phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P(2)).	phosphoinositide-3,4-bisphosphate	189-201	sperm hammerhead 2	Mus musculus	0-3
15135055-1	2004	SH2 domain containing inositol polyphosphate 5-phosphatase (SHIP2) dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) into phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P(2)).	phosphoinositide-3,4-bisphosphate	189-201	inositol polyphosphate phosphatase-like 1	Mus musculus	60-65
12822887-1	2003	Growth factor binding events to receptor tyrosine kinases result in activation of phosphatidylinositol 3-kinase (PI3K), and activated PI3K generates the membrane-bound second messengers phosphatidylinositol 3,4-diphosphate [PI(3,4)P2] and PI(3,4,5)P3, which mediate membrane translocation of the phosphoinositide-dependent kinase-1 (PDK1) and protein kinase B (PKB, also known as Akt).	phosphoinositide-3,4-bisphosphate	224-233	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	82-111
12605860-8	2003	The versatility and general utility of this approach were demonstrated by exchanging the GRP1 PH domain for that of TAPP1 (which binds PtdIns(3,4)P(2) and not PtdIns(3,4,5)P(3)).	phosphoinositide-3,4-bisphosphate	135-147	cytohesin 3	Mus musculus	89-93
12605860-8	2003	The versatility and general utility of this approach were demonstrated by exchanging the GRP1 PH domain for that of TAPP1 (which binds PtdIns(3,4)P(2) and not PtdIns(3,4,5)P(3)).	phosphoinositide-3,4-bisphosphate	135-147	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	Mus musculus	116-121
12407113-7	2003	The inhibitory effect of wortmannin on Rap1B activation was overcome by addition of phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)), but not PtdIns(3,4)P(2), although both lipids were found to support phosphorylation of Akt.	phosphoinositide-3,4-bisphosphate	154-166	RAP1B, member of RAS oncogene family	Homo sapiens	39-44
12145149-1	2002	SH-2-containing inositol 5"-phosphatase 2 (SHIP-2) is a physiologically important lipid phosphatase that functions to hydrolyze phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling.	phosphoinositide-3,4-bisphosphate	186-195	inositol polyphosphate phosphatase-like 1	Mus musculus	43-49
11756165-5	2002	Results show that platelet adhesion and spreading on immobilized VWF results in a specific increase in the PI 3-kinase lipid product, PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	134-146	von Willebrand factor	Homo sapiens	65-68
11756165-5	2002	Results show that platelet adhesion and spreading on immobilized VWF results in a specific increase in the PI 3-kinase lipid product, PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	134-146	peptidase inhibitor 3	Homo sapiens	107-111
11716755-5	2001	TPIP alpha displays similar phosphoinositide 3-phosphatase activity compared with PTEN against PtdIns(3,4,5)P(3), PtdIns(3,5)P(2), PtdIns(3,4)P(2) and PtdIns(3)P, has N-terminal transmembrane domains and appears to be localized on the endoplasmic reticulum.	phosphoinositide-3,4-bisphosphate	131-143	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	Homo sapiens	0-4
11300871-11	2001	Moreover, our model can be used to predict the binding affinity of PI3-K-generated phospholipids and rationalize the specificity of the Akt PH domain for PI(3,4)P2, as opposed to other phospholipids such as PI(3)P and PI(3,4,5)P3.	phosphoinositide-3,4-bisphosphate	154-163	AKT serine/threonine kinase 1	Homo sapiens	136-139
11513726-1	2001	Phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] and its immediate breakdown product PtdIns(3,4)P(2) function as second messengers in growth factor- and insulin-induced signalling pathways.	phosphoinositide-3,4-bisphosphate	97-109	insulin	Homo sapiens	165-172
11513726-3	2001	Many of these proteins, such as protein kinase B, phosphoinositide-dependent kinase 1 and the dual adaptor for phosphotyrosine and 3-phosphoinositides (DAPP1) interact with both PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2) with similar affinity.	phosphoinositide-3,4-bisphosphate	200-212	dual adaptor of phosphotyrosine and 3-phosphoinositides 1	Homo sapiens	152-157
11513726-4	2001	Recently, a new PH-domain-containing protein, termed tandem PH-domain-containing protein (TAPP) 1, was described which is the first protein reported to bind PtdIns(3,4)P(2) specifically.	phosphoinositide-3,4-bisphosphate	157-169	pleckstrin homology domain containing A1	Homo sapiens	60-97
11513726-8	2001	We show that mutation of this glycine to alanine in DAPP1 converts DAPP1 into a TAPP1-like PH domain that only interacts with PtdIns(3,4)P(2), whereas the alanine to glycine mutation in TAPP1 permits the TAPP1 PH domain to interact with PtdIns(3,4,5)P(3).	phosphoinositide-3,4-bisphosphate	126-138	dual adaptor of phosphotyrosine and 3-phosphoinositides 1	Homo sapiens	52-57
11513726-8	2001	We show that mutation of this glycine to alanine in DAPP1 converts DAPP1 into a TAPP1-like PH domain that only interacts with PtdIns(3,4)P(2), whereas the alanine to glycine mutation in TAPP1 permits the TAPP1 PH domain to interact with PtdIns(3,4,5)P(3).	phosphoinositide-3,4-bisphosphate	126-138	dual adaptor of phosphotyrosine and 3-phosphoinositides 1	Homo sapiens	67-72
11513726-8	2001	We show that mutation of this glycine to alanine in DAPP1 converts DAPP1 into a TAPP1-like PH domain that only interacts with PtdIns(3,4)P(2), whereas the alanine to glycine mutation in TAPP1 permits the TAPP1 PH domain to interact with PtdIns(3,4,5)P(3).	phosphoinositide-3,4-bisphosphate	126-138	pleckstrin homology domain containing A1	Homo sapiens	80-85
11504939-8	2001	3-PAP immunoprecipitates isolated from platelet cytosol hydrolyzed the D3-phosphate from PtdIns(3)P and PtdIns 3,4-bisphosphate [PtdIns(3,4)P(2)].	phosphoinositide-3,4-bisphosphate	129-141	myotubularin related protein 12	Homo sapiens	0-5
11672432-0	2001	AtPIP5K1, an Arabidopsis thaliana phosphatidylinositol phosphate kinase, synthesizes PtdIns(3,4)P(2) and PtdIns(4,5)P(2) in vitro and is inhibited by phosphorylation.	phosphoinositide-3,4-bisphosphate	85-97	phosphatidylinositol-4-phosphate 5-kinase 1	Arabidopsis thaliana	0-8
11672432-2	2001	We demonstrate here that the previously identified AtPIP5K1 gene from Arabidopsis thaliana encodes a PIPkin with dual substrate specificity in vitro, capable of phosphorylating PtdIns3P and PtdIns4P to PtdIns(3,4)P(2) and PtdIns(4,5)P(2) respectively.	phosphoinositide-3,4-bisphosphate	202-214	phosphatidylinositol-4-phosphate 5-kinase 1	Arabidopsis thaliana	51-59
11692174-6	2001	Although PI(3,4,5)P3 and PI(3,4)P2 are known to possibly activate a downstream molecule of PI3-kinase Akt in vitro, overexpression of WT-SHIP2 inhibited insulin-induced phosphorylation and activation of Akt.	phosphoinositide-3,4-bisphosphate	25-34	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
11692174-6	2001	Although PI(3,4,5)P3 and PI(3,4)P2 are known to possibly activate a downstream molecule of PI3-kinase Akt in vitro, overexpression of WT-SHIP2 inhibited insulin-induced phosphorylation and activation of Akt.	phosphoinositide-3,4-bisphosphate	25-34	inositol polyphosphate phosphatase-like 1	Rattus norvegicus	137-142
11433300-1	2001	We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P(2)) and phosphatidylinositol-3-phosphate (PtdIns(3)P), respectively.	phosphoinositide-3,4-bisphosphate	143-155	neutrophil cytosolic factor 1	Homo sapiens	36-43
11433300-1	2001	We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P(2)) and phosphatidylinositol-3-phosphate (PtdIns(3)P), respectively.	phosphoinositide-3,4-bisphosphate	143-155	neutrophil cytosolic factor 4	Homo sapiens	48-55
10512757-3	1999	We found that IAS almost totally blocked thrombin-induced production of phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P(2)] and phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)].	phosphoinositide-3,4-bisphosphate	111-123	coagulation factor II, thrombin	Homo sapiens	41-49
11238900-3	2001	We recently cloned rat SH2-containing inositol phosphatase 2 (SHIP2) cDNA which possesses the 5"-phosphatase activity to hydrolyze PI(3,4,5)P3 to PI 3,4-bisphosphate [PI(3,4)P2] and which is mainly expressed in the target tissues of insulin.	phosphoinositide-3,4-bisphosphate	167-176	inositol polyphosphate phosphatase-like 1	Rattus norvegicus	23-60
11238900-3	2001	We recently cloned rat SH2-containing inositol phosphatase 2 (SHIP2) cDNA which possesses the 5"-phosphatase activity to hydrolyze PI(3,4,5)P3 to PI 3,4-bisphosphate [PI(3,4)P2] and which is mainly expressed in the target tissues of insulin.	phosphoinositide-3,4-bisphosphate	167-176	inositol polyphosphate phosphatase-like 1	Rattus norvegicus	62-67
11238900-8	2001	Both PI(3,4,5)P3 and PI(3,4)P2 were known to possibly activate downstream targets Akt and protein kinase C lambda in vitro.	phosphoinositide-3,4-bisphosphate	21-30	AKT serine/threonine kinase 1	Rattus norvegicus	82-85
11238900-8	2001	Both PI(3,4,5)P3 and PI(3,4)P2 were known to possibly activate downstream targets Akt and protein kinase C lambda in vitro.	phosphoinositide-3,4-bisphosphate	21-30	protein kinase C, iota	Rattus norvegicus	90-113
11086166-2	2000	Furthermore, the potentiating effect of adrenaline on thrombin-induced PtdIns(3, 4)P(2) production was independent on secreted ADP, whereas, the effect of adrenaline on SFRLLN-induced PtdIns(3,4)P(2) production was completely dependent of secreted ADP.	phosphoinositide-3,4-bisphosphate	184-196	coagulation factor II, thrombin	Homo sapiens	54-62
10998360-4	2000	Tiam1 bound to polyphosphorylated inositol lipids in the rank order PtdIns(3,4,5)P(3)>PtdIns(3,4)P(2) >>PtdIns(4,5)P(2), and this binding could be attributed to the N-terminal pleckstrin-homology (N-PH) domain.	phosphoinositide-3,4-bisphosphate	89-101	T cell lymphoma invasion and metastasis 1	Mus musculus	0-5
10998360-5	2000	Both PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2) enhanced Tiam1 guanine nucleotide exchange activity in vitro, but PtdIns(4,5)P(2) had no effect.	phosphoinositide-3,4-bisphosphate	27-39	T cell lymphoma invasion and metastasis 1	Mus musculus	52-57
10880360-2	2000	DAPP1 exhibits a high-affinity interaction with PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2), which bind to the PH domain.	phosphoinositide-3,4-bisphosphate	70-82	dual adaptor of phosphotyrosine and 3-phosphoinositides 1	Homo sapiens	0-5
10880360-4	2000	Treatment of cells with phosphoinositide 3-kinase (PI 3-kinase) inhibitors or expression of a dominant-negative PI 3-kinase prevent phosphorylation of DAPP1 at Tyr(139), and a PH-domain mutant of DAPP1, which does not interact with PtdIns(3,4,5)P(3) or PtdIns(3,4)P(2), is not phosphorylated at Tyr(139) following agonist stimulation of cells.	phosphoinositide-3,4-bisphosphate	253-265	dual adaptor of phosphotyrosine and 3-phosphoinositides 1	Homo sapiens	151-156
10545132-11	1999	Three synthetic isoforms of PIP2, PI(4,5)P2, PI(3,4)P2 and PI(3,5)P2, activated GIRK channels with similar potencies.	phosphoinositide-3,4-bisphosphate	45-54	potassium inwardly rectifying channel subfamily J member 3 S homeolog	Xenopus laevis	80-84
10512757-5	1999	When testing the effect of each inhibitor individually we found the strongest inhibition of thrombin-induced PtdIns(3,4)P(2) production with the ADP scavenger system CP/CPK.	phosphoinositide-3,4-bisphosphate	109-121	coagulation factor II, thrombin	Homo sapiens	92-100
10512757-5	1999	When testing the effect of each inhibitor individually we found the strongest inhibition of thrombin-induced PtdIns(3,4)P(2) production with the ADP scavenger system CP/CPK.	phosphoinositide-3,4-bisphosphate	109-121	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	169-172
10512757-6	1999	Furthermore, we found a strong synergistic effect between exogenously added ADP and thrombin on production of PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	110-122	coagulation factor II, thrombin	Homo sapiens	84-92
11043766-7	2000	The lipid phosphatases SHIP and PTEN negatively regulate production of PI(3,4)P2 and PI(3,4,S)P3 and therefore function to put a "brake" on the PI3K pathway.	phosphoinositide-3,4-bisphosphate	71-80	inositol polyphosphate-5-phosphatase D	Mus musculus	23-27
11043766-7	2000	The lipid phosphatases SHIP and PTEN negatively regulate production of PI(3,4)P2 and PI(3,4,S)P3 and therefore function to put a "brake" on the PI3K pathway.	phosphoinositide-3,4-bisphosphate	71-80	phosphatase and tensin homolog	Mus musculus	32-36
10880360-8	2000	These findings indicate that, following activation of PI 3-kinases, PtdIns(3,4,5)P(3) or PtdIns(3,4)P(2) bind to DAPP1, recruiting it to the plasma membrane where it becomes phosphorylated at Tyr(139) by a Src-family tyrosine kinase.	phosphoinositide-3,4-bisphosphate	89-101	dual adaptor of phosphotyrosine and 3-phosphoinositides 1	Homo sapiens	113-118
10880360-8	2000	These findings indicate that, following activation of PI 3-kinases, PtdIns(3,4,5)P(3) or PtdIns(3,4)P(2) bind to DAPP1, recruiting it to the plasma membrane where it becomes phosphorylated at Tyr(139) by a Src-family tyrosine kinase.	phosphoinositide-3,4-bisphosphate	89-101	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	206-209
10593888-5	1999	GIRK1/GIRK4 channels were activated with a similar efficacy by PtdIns(3,4)P(2), PtdIns(3,5)P(2), PtdIns(4,5)P(2), and PtdIns(3,4,5)P(3).	phosphoinositide-3,4-bisphosphate	63-75	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	0-5
10593888-5	1999	GIRK1/GIRK4 channels were activated with a similar efficacy by PtdIns(3,4)P(2), PtdIns(3,5)P(2), PtdIns(4,5)P(2), and PtdIns(3,4,5)P(3).	phosphoinositide-3,4-bisphosphate	63-75	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	6-11
10593888-6	1999	In contrast, IRK1 channels were not activated by PtdIns(3,4)P(2) and only marginally by high concentrations of PtdIns(3,5)P(2).	phosphoinositide-3,4-bisphosphate	49-61	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	13-17
10556805-2	1999	A major route for degradation of PtdIns(3,4,5)P(3) (and hence, regulation of PtdIns(3,4,5)P(3)-driven effector pathways), involves its conversion to PtdIns(3,4)P(2) by the 145-kDa SH2-containing inositol (poly)phosphate 5-phosphatase (SHIP).	phosphoinositide-3,4-bisphosphate	149-161	inositol polyphosphate-5-phosphatase D	Mus musculus	180-233
10556805-2	1999	A major route for degradation of PtdIns(3,4,5)P(3) (and hence, regulation of PtdIns(3,4,5)P(3)-driven effector pathways), involves its conversion to PtdIns(3,4)P(2) by the 145-kDa SH2-containing inositol (poly)phosphate 5-phosphatase (SHIP).	phosphoinositide-3,4-bisphosphate	149-161	inositol polyphosphate-5-phosphatase D	Mus musculus	235-239
10432293-3	1999	DAPP1 is widely expressed and exhibits high-affinity interactions with PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2), but not with other phospholipids tested.	phosphoinositide-3,4-bisphosphate	93-105	dual adaptor of phosphotyrosine and 3-phosphoinositides 1	Homo sapiens	0-5
10432293-4	1999	These observations predict that DAPP1 will interact with both tyrosine phosphorylated proteins and 3-phosphoinositides and may therefore play a role in regulating the location and/or activity of such proteins(s) in response to agonists that elevate PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2).	phosphoinositide-3,4-bisphosphate	271-283	dual adaptor of phosphotyrosine and 3-phosphoinositides 1	Homo sapiens	32-37
10454216-6	1999	Membrane attachment of PKB is mediated by its pleckstrin homology domain binding to PI-3,4,5-trisphosphate or PI-3,4-bisphosphate with high affinity.	phosphoinositide-3,4-bisphosphate	110-129	AKT serine/threonine kinase 1	Homo sapiens	23-26
10467403-6	1999	NGF-stimulated tyrosine phosphorylation of the Trk(def)+PI 3-kinase addback receptor, resulted in the direct association and selective activation of PI 3-kinase in vitro and the production of PI(3,4)P2 and PI(3,4,5)P3 in vivo (comparable to wild-type).	phosphoinositide-3,4-bisphosphate	192-201	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	47-50
10467403-6	1999	NGF-stimulated tyrosine phosphorylation of the Trk(def)+PI 3-kinase addback receptor, resulted in the direct association and selective activation of PI 3-kinase in vitro and the production of PI(3,4)P2 and PI(3,4,5)P3 in vivo (comparable to wild-type).	phosphoinositide-3,4-bisphosphate	192-201	UTP25 small subunit processome component	Rattus norvegicus	51-54
9852043-2	1998	Although both phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,4-bisphosphate (PI 3,4-P2) have been implicated in the regulation of Akt activity in vitro, the relative roles of these two phospholipids in vivo are not well understood.	phosphoinositide-3,4-bisphosphate	105-114	AKT serine/threonine kinase 1	Homo sapiens	158-161
10102683-2	1999	PKB is regulated by the lipid products of phosphoinositide 3-kinase (PI 3-kinase), phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2], and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].	phosphoinositide-3,4-bisphosphate	122-131	protein tyrosine kinase 2 beta	Homo sapiens	0-3
10102683-4	1999	Treatment of intact 3T3-L1 preadipocytes with synthetic 3-phosphorylated phosphoinositides revealed that only PI(3,4)P2 stimulated PKB activity.	phosphoinositide-3,4-bisphosphate	110-119	protein tyrosine kinase 2 beta	Homo sapiens	131-134
10029412-6	1999	Clones that constitutively overexpressed p85 exhibited a higher degree of PI-3,4-P2 synthesis and a corresponding increase in their resistance to ultraviolet radiation.	phosphoinositide-3,4-bisphosphate	74-83	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	41-44
10194451-13	1999	Because recent evidence has clearly implicated both PI(3,4, 5)P3 and PI(3,4)P2 in growth factor-mediated signaling, our finding that both SHIP1 and SHIP2 are constitutively tyrosine phosphorylated in CML primary hematopoietic progenitor cells may thus have important implications in p210(bcr/abl)-mediated myeloid expansion.	phosphoinositide-3,4-bisphosphate	69-78	inositol polyphosphate-5-phosphatase D	Homo sapiens	138-143
10194451-13	1999	Because recent evidence has clearly implicated both PI(3,4, 5)P3 and PI(3,4)P2 in growth factor-mediated signaling, our finding that both SHIP1 and SHIP2 are constitutively tyrosine phosphorylated in CML primary hematopoietic progenitor cells may thus have important implications in p210(bcr/abl)-mediated myeloid expansion.	phosphoinositide-3,4-bisphosphate	69-78	inositol polyphosphate phosphatase like 1	Homo sapiens	148-153
9852043-5	1998	The nature of this regulation, positive or negative, might also reveal the relative contribution of PIP3 and PI 3,4-P2 to Akt activation in vivo.	phosphoinositide-3,4-bisphosphate	109-118	AKT serine/threonine kinase 1	Homo sapiens	122-125
9852043-8	1998	The SHIP-dependent inhibition of Akt activation also suggests that PIP3 plays a greater role in Akt activation than PI 3,4-P2 in vivo.	phosphoinositide-3,4-bisphosphate	116-125	inositol polyphosphate-5-phosphatase D	Homo sapiens	4-8
9852043-8	1998	The SHIP-dependent inhibition of Akt activation also suggests that PIP3 plays a greater role in Akt activation than PI 3,4-P2 in vivo.	phosphoinositide-3,4-bisphosphate	116-125	AKT serine/threonine kinase 1	Homo sapiens	33-36
9234699-3	1997	We demonstrate here the integrin-dependent accumulation of the PI 3-kinase products, PI 3,4-bisphosphate [PI(3,4)P2] and PI(3,4,5)P3, as well as activation of AKT kinase, a serine/threonine kinase that can be stimulated by binding of PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	234-243	AKT serine/threonine kinase 1	Homo sapiens	159-162
9550703-3	1998	Members of this family contain a carboxy-terminal pleckstrin homology (PH) domain which, in the case of GRP-1, has been shown to bind the second messenger phosphatidylinositol 3,4,5-trisphosphate (PIP3) in preference to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) in vitro [3,4].	phosphoinositide-3,4-bisphosphate	313-322	glutamine repeat protein 1	Mus musculus	104-109
9624178-3	1998	MSS4 has dual substrate specificity in vitro, converting PI(4)P to PI(4, 5)P2 and to a lesser extent PI(3)P to PI(3,4)P2; no activity was detected with PI or PI(5)P as a substrate.	phosphoinositide-3,4-bisphosphate	111-120	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	0-4
9511732-18	1998	Thus, activated PI 3-kinase may direct a flux of profilin-actin complexes to the membrane locations of activated insulin receptors, where, due to the release of actin monomers after binding of profilactin to PI(3,4)P2 and PI(3,4,5)P3, massive actin polymerization is initiated.	phosphoinositide-3,4-bisphosphate	208-217	insulin	Homo sapiens	113-120
9234699-8	1997	We conclude that integrin-mediated adhesion to fibronectin results in the accumulation of the PI 3-kinase products PI(3,4)P2 and PI(3,4,5)P3 as well as the PI 3-kinase-dependent activation of the kinases Raf-1, Mek-1, Erk-2, and AKT and that PI 3-kinase may function upstream of Raf-1 but downstream of Ras in integrin activation of Erk-2 MAP and AKT kinases.	phosphoinositide-3,4-bisphosphate	115-124	fibronectin 1	Homo sapiens	47-58
9247112-1	1997	The initial steps in insulin signal transduction occur at the plasma membrane and lead to the activation of phosphatidylinositide (PtdIns) 3-kinase and the formation of PtdIns(3,4,5,)P3 in the inner leaflet of the plasma membrane which is then converted to PtdIns(3,4)P2 by a specific phosphatase.	phosphoinositide-3,4-bisphosphate	257-270	insulin	Homo sapiens	21-28
9247112-2	1997	Inhibitors of PtdIns 3-kinase suppress nearly all the metabolic actions of insulin indicating that PtdIns(3,4,5)P3 and/or PtdIns(3,4)P2 are key "second messengers" for this hormone.	phosphoinositide-3,4-bisphosphate	122-135	insulin	Homo sapiens	75-82
9247112-5	1997	The first enzyme in this cascade is termed 3-phosphoinositide-dependent protein kinase (PDK1), because it is only active in the presence of PtdIns(3,4,5)P3 or PtdIns(3,4)P2.	phosphoinositide-3,4-bisphosphate	159-172	pyruvate dehydrogenase kinase 1	Homo sapiens	88-92
8781408-4	1996	Here we report that PI 3,4-P2 and PI 3,4,5-P3, the enzymatic products of PI 3-kinase, accumulate in metabolically labeled transformed hematopoietic cells, in contrast to our previous report on the lack of accumulation of PI 3-kinase products in nontransformed NIH 3T3 fibroblasts that express p210 BCR/abl.	phosphoinositide-3,4-bisphosphate	20-29	envoplakin	Mus musculus	293-297
8781408-4	1996	Here we report that PI 3,4-P2 and PI 3,4,5-P3, the enzymatic products of PI 3-kinase, accumulate in metabolically labeled transformed hematopoietic cells, in contrast to our previous report on the lack of accumulation of PI 3-kinase products in nontransformed NIH 3T3 fibroblasts that express p210 BCR/abl.	phosphoinositide-3,4-bisphosphate	20-29	BCR activator of RhoGEF and GTPase	Mus musculus	298-301
8781408-4	1996	Here we report that PI 3,4-P2 and PI 3,4,5-P3, the enzymatic products of PI 3-kinase, accumulate in metabolically labeled transformed hematopoietic cells, in contrast to our previous report on the lack of accumulation of PI 3-kinase products in nontransformed NIH 3T3 fibroblasts that express p210 BCR/abl.	phosphoinositide-3,4-bisphosphate	20-29	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	302-305
7791763-7	1995	Insulin stimulation of immature Xenopus oocytes activates PI 3-kinase in vivo [as indicated by an elevation of PI(3,4)P2 and PI(3,4,5)P3] as well as oocyte maturation (as indicated by germinal vesicle breakdown).	phosphoinositide-3,4-bisphosphate	111-120	insulin S homeolog	Xenopus laevis	0-7
7791763-7	1995	Insulin stimulation of immature Xenopus oocytes activates PI 3-kinase in vivo [as indicated by an elevation of PI(3,4)P2 and PI(3,4,5)P3] as well as oocyte maturation (as indicated by germinal vesicle breakdown).	phosphoinositide-3,4-bisphosphate	111-120	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	58-69
2156815-2	1990	In [32P]o-phosphate-labeled platelets, PtdIns(3,4)P2 increases in 2 min to 613% of the basal level in response to 1 unit/ml alpha-thrombin and 295% in response to 5 microM U46619.	phosphoinositide-3,4-bisphosphate	39-52	coagulation factor II, thrombin	Homo sapiens	130-138
2177144-1	1990	In a recent publication we showed that addition of mouse epidermal growth factor (mEGF) to MA-10 Leydig tumor cells rapidly leads to an increase in the incorporation of [3H]inositol-derived radioactivity into an unusual lipid that was identified as phosphatidylinositol-3,4-bisphosphate (PI-3,4-P2).	phosphoinositide-3,4-bisphosphate	288-297	epidermal growth factor	Mus musculus	82-86
2177144-3	1990	Inasmuch as mEGF modulates the differentiated functions of MA-10 cells in a number of ways, our findings raised the possibility that PI-3,4-P2 may be an intracellular mediator of these actions of mEGF.	phosphoinositide-3,4-bisphosphate	133-142	epidermal growth factor	Mus musculus	196-200
33771931-3	2022	PI(4,5)P2 normally restricted to the proximal segment redistributed to the entire length of cilia in Inpp5e knockout mice with a reduction in PI(3,4)P2 and elevation of PI(3,4,5)P3 in the dendritic knob.	phosphoinositide-3,4-bisphosphate	142-151	inositol polyphosphate-5-phosphatase E	Mus musculus	101-107
2154447-4	1990	We demonstrate the formation of PtdIns(3,4)P2 in human platelets and show that the synthesis of this lipid (and of PtdIns(4,5)P2) is stimulated during activation of platelets by thrombin.	phosphoinositide-3,4-bisphosphate	32-45	coagulation factor II, thrombin	Homo sapiens	178-186
34990021-2	2022	Invadopodia maturation requires GPCR activation of PI3Kbeta and its coupling to SHIP2 to produce PI(3,4)P2 .	phosphoinositide-3,4-bisphosphate	97-106	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	51-59
34385319-2	2021	Akt responds specifically to the lipid second messengers phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) and phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) via its PH domain, leading to phosphorylation of its activation loop and the hydrophobic motif of its kinase domain, which are critical for activity.	phosphoinositide-3,4-bisphosphate	155-164	AKT serine/threonine kinase 1	Homo sapiens	0-3
34385319-4	2021	This interface persists even after stoichiometric phosphorylation, thereby restricting maximum Akt activity to PI(3,4,5)P3- or PI(3,4)P2-containing membranes.	phosphoinositide-3,4-bisphosphate	127-136	AKT serine/threonine kinase 1	Homo sapiens	95-98
34314064-1	2021	The Src homology 2 containing inositol 5-phosphatase 2 (SHIP2) is a large multidomain enzyme that catalyzes the dephosphorylation of the phospholipid phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3 ) to form PI(3,4)P2 .	phosphoinositide-3,4-bisphosphate	213-222	inositol polyphosphate phosphatase like 1	Homo sapiens	4-54
34314064-1	2021	The Src homology 2 containing inositol 5-phosphatase 2 (SHIP2) is a large multidomain enzyme that catalyzes the dephosphorylation of the phospholipid phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3 ) to form PI(3,4)P2 .	phosphoinositide-3,4-bisphosphate	213-222	inositol polyphosphate phosphatase like 1	Homo sapiens	56-61
35387990-7	2022	These results imply that the PDK1-mediated activation of effector kinases, including Akt, PKC, Sgk, S6K and RSK, many of whom are not directly regulated by phosphoinositides, is also likely to be dependent on PIP3 or PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	217-226	pyruvate dehydrogenase kinase 1	Homo sapiens	29-33
35387990-7	2022	These results imply that the PDK1-mediated activation of effector kinases, including Akt, PKC, Sgk, S6K and RSK, many of whom are not directly regulated by phosphoinositides, is also likely to be dependent on PIP3 or PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	217-226	AKT serine/threonine kinase 1	Homo sapiens	85-88
35387990-7	2022	These results imply that the PDK1-mediated activation of effector kinases, including Akt, PKC, Sgk, S6K and RSK, many of whom are not directly regulated by phosphoinositides, is also likely to be dependent on PIP3 or PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	217-226	serum/glucocorticoid regulated kinase 1	Homo sapiens	95-98
35387990-7	2022	These results imply that the PDK1-mediated activation of effector kinases, including Akt, PKC, Sgk, S6K and RSK, many of whom are not directly regulated by phosphoinositides, is also likely to be dependent on PIP3 or PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	217-226	ribosomal protein S6 kinase B1	Homo sapiens	100-103
35098698-4	2022	Mechanistically, it is demonstrated that PI3KC2alpha synthetizes a pool of PI(3,4)P2 at focal adhesions that lowers their stability and directs breast cancer cell migration, invasion, and metastasis.	phosphoinositide-3,4-bisphosphate	75-84	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	41-52
35098698-5	2022	PI(3,4)P2 locally produced by PI3KC2alpha at focal adhesions recruits the Ras GTPase activating protein 3 (RASA3), which inactivates R-RAS, leading to increased focal adhesion turnover, migration, and invasion both in vitro and in vivo.	phosphoinositide-3,4-bisphosphate	0-9	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	30-41
35098698-5	2022	PI(3,4)P2 locally produced by PI3KC2alpha at focal adhesions recruits the Ras GTPase activating protein 3 (RASA3), which inactivates R-RAS, leading to increased focal adhesion turnover, migration, and invasion both in vitro and in vivo.	phosphoinositide-3,4-bisphosphate	0-9	RAS p21 protein activator 3	Homo sapiens	74-105
35098698-5	2022	PI(3,4)P2 locally produced by PI3KC2alpha at focal adhesions recruits the Ras GTPase activating protein 3 (RASA3), which inactivates R-RAS, leading to increased focal adhesion turnover, migration, and invasion both in vitro and in vivo.	phosphoinositide-3,4-bisphosphate	0-9	RAS p21 protein activator 3	Homo sapiens	107-112
34709416-7	2021	In addition, the product of SHIP2 enzymatic activity (phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)) was tightly associated with DAT, as shown by co-IP and by colocalization of mCherry-DAT with a specific biosensor for this phospholipid.	phosphoinositide-3,4-bisphosphate	93-102	inositol polyphosphate phosphatase like 1	Homo sapiens	28-33
34709416-7	2021	In addition, the product of SHIP2 enzymatic activity (phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)) was tightly associated with DAT, as shown by co-IP and by colocalization of mCherry-DAT with a specific biosensor for this phospholipid.	phosphoinositide-3,4-bisphosphate	93-102	solute carrier family 6 member 3	Homo sapiens	133-136
34709416-7	2021	In addition, the product of SHIP2 enzymatic activity (phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)) was tightly associated with DAT, as shown by co-IP and by colocalization of mCherry-DAT with a specific biosensor for this phospholipid.	phosphoinositide-3,4-bisphosphate	93-102	solute carrier family 6 member 3	Homo sapiens	189-192
35387990-7	2022	These results imply that the PDK1-mediated activation of effector kinases, including Akt, PKC, Sgk, S6K and RSK, many of whom are not directly regulated by phosphoinositides, is also likely to be dependent on PIP3 or PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	217-226	ribosomal protein S6 kinase A2	Homo sapiens	108-111
34990021-2	2022	Invadopodia maturation requires GPCR activation of PI3Kbeta and its coupling to SHIP2 to produce PI(3,4)P2 .	phosphoinositide-3,4-bisphosphate	97-106	inositol polyphosphate phosphatase like 1	Homo sapiens	80-85
33953730-3	2021	PIP3 is subject to dephosphorylation by several 5" phosphatases, including SHIP family phosphatases, which convert the PI3K product and lipid second messenger phosphatidylinositol 3,4,5-trisphosphate (PIP3) into PI(3,4)P2, a lipid second messenger in its own right.	phosphoinositide-3,4-bisphosphate	212-221	inositol polyphosphate-5-phosphatase D	Homo sapiens	75-79
34035258-1	2021	INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer.	phosphoinositide-3,4-bisphosphate	51-60	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	0-6
34035258-1	2021	INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer.	phosphoinositide-3,4-bisphosphate	51-60	AKT serine/threonine kinase 1	Homo sapiens	23-26
34035258-5	2021	We used integrated proteomics, transcriptomics and imaging to demonstrate INPP4B localized to late endosomes via interaction with Rab7, which increased endosomal PI3Kalpha-dependent PI(3,4)P2 to PI(3)P conversion, late endosome/lysosome number and cargo trafficking, resulting in enhanced GSK3beta lysosomal degradation and activation of Wnt/beta-catenin signaling.	phosphoinositide-3,4-bisphosphate	182-191	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	74-80
34035258-5	2021	We used integrated proteomics, transcriptomics and imaging to demonstrate INPP4B localized to late endosomes via interaction with Rab7, which increased endosomal PI3Kalpha-dependent PI(3,4)P2 to PI(3)P conversion, late endosome/lysosome number and cargo trafficking, resulting in enhanced GSK3beta lysosomal degradation and activation of Wnt/beta-catenin signaling.	phosphoinositide-3,4-bisphosphate	182-191	RAB7B, member RAS oncogene family	Homo sapiens	130-134
34035258-5	2021	We used integrated proteomics, transcriptomics and imaging to demonstrate INPP4B localized to late endosomes via interaction with Rab7, which increased endosomal PI3Kalpha-dependent PI(3,4)P2 to PI(3)P conversion, late endosome/lysosome number and cargo trafficking, resulting in enhanced GSK3beta lysosomal degradation and activation of Wnt/beta-catenin signaling.	phosphoinositide-3,4-bisphosphate	182-191	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	162-171
34035258-7	2021	Therefore, INPP4B facilitates PI3Kalpha crosstalk with Wnt signaling in ER+ breast cancer via PI(3,4)P2 to PI(3)P conversion on late endosomes, suggesting these tumors may be targeted with combined PI3K and Wnt/beta-catenin therapies.	phosphoinositide-3,4-bisphosphate	94-103	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	11-17
2549071-12	1989	Hence formation of PI(3,4)P2 and PIP3 (presumed to be PI(3,4,5)P3) correlates closely with the early events of neutrophil activation.	phosphoinositide-3,4-bisphosphate	19-28	peptidase inhibitor 3	Homo sapiens	54-65
34035258-7	2021	Therefore, INPP4B facilitates PI3Kalpha crosstalk with Wnt signaling in ER+ breast cancer via PI(3,4)P2 to PI(3)P conversion on late endosomes, suggesting these tumors may be targeted with combined PI3K and Wnt/beta-catenin therapies.	phosphoinositide-3,4-bisphosphate	94-103	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	30-39
33947811-3	2021	PI(3,4)P2 is locally produced by PIK3CA and SHIP2 and is concentrated at the trailing edge of the invadopodium arc.	phosphoinositide-3,4-bisphosphate	0-9	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	33-39
33947811-3	2021	PI(3,4)P2 is locally produced by PIK3CA and SHIP2 and is concentrated at the trailing edge of the invadopodium arc.	phosphoinositide-3,4-bisphosphate	0-9	inositol polyphosphate phosphatase like 1	Homo sapiens	44-49
33947811-4	2021	The PI(3,4)P2-rich compartment locally forms small puncta (membrane buds) in a SNX9-dependent manner, recruits dynein activator Hook1 through AKTIP, and rearranges into micrometer-long tubular invaginations (membrane tubes).	phosphoinositide-3,4-bisphosphate	4-13	sorting nexin 9	Homo sapiens	79-83
33947811-4	2021	The PI(3,4)P2-rich compartment locally forms small puncta (membrane buds) in a SNX9-dependent manner, recruits dynein activator Hook1 through AKTIP, and rearranges into micrometer-long tubular invaginations (membrane tubes).	phosphoinositide-3,4-bisphosphate	4-13	hook microtubule tethering protein 1	Homo sapiens	128-133
33947811-4	2021	The PI(3,4)P2-rich compartment locally forms small puncta (membrane buds) in a SNX9-dependent manner, recruits dynein activator Hook1 through AKTIP, and rearranges into micrometer-long tubular invaginations (membrane tubes).	phosphoinositide-3,4-bisphosphate	4-13	AKT interacting protein	Homo sapiens	142-147
33947811-6	2021	Activated integrin-beta3 is locally internalized through the pathway of PI(3,4)P2-mediated membrane invagination and is then actively recycled.	phosphoinositide-3,4-bisphosphate	72-81	integrin subunit beta 3	Homo sapiens	10-24
33443153-8	2021	Together, our results support a model for the cellular function of ADAP1, where KIF13B transports ADAP1 until it encounters high PIP3/PI(3,4)P2 concentrations in the plasma membrane.	phosphoinositide-3,4-bisphosphate	134-143	ArfGAP with dual PH domains 1	Homo sapiens	67-72
33443153-8	2021	Together, our results support a model for the cellular function of ADAP1, where KIF13B transports ADAP1 until it encounters high PIP3/PI(3,4)P2 concentrations in the plasma membrane.	phosphoinositide-3,4-bisphosphate	134-143	kinesin family member 13B	Homo sapiens	80-86
32513774-6	2020	Mechanistically, we found that INPP4B deficiency increases PI(3,4)P2 levels in endocytic vesicles but not at the plasma membrane.	phosphoinositide-3,4-bisphosphate	59-68	inositol polyphosphate-4-phosphatase, type II	Mus musculus	31-37
33087443-4	2020	Here we investigate the associations of alpha-Syn with the acidic phosphoinositides (PIPs), phosphatidylinositol 4,5-bisphosphate (PI4,5P2) and phosphatidylinositol 3,4-bisphosphate (PI3,4P2).	phosphoinositide-3,4-bisphosphate	183-190	synuclein alpha	Homo sapiens	40-49
32535200-3	2020	The PI 5-phosphatase SHIP2 is a critical enzyme modulating PI(3,4,5)P3, PI(4,5)P2 and PI(3,4)P2 content in the cell.	phosphoinositide-3,4-bisphosphate	86-95	inositol polyphosphate phosphatase like 1	Homo sapiens	21-26
32296634-4	2020	The selective cellular functions for PI(3,4)P2 independent of PI(3,4,5)P3 have been recently described, including clathrin-mediated endocytosis and mTOR regulation.	phosphoinositide-3,4-bisphosphate	37-46	mechanistic target of rapamycin kinase	Homo sapiens	148-152
32413098-2	2020	INPP4B dephosphorylates phospholipids at the 4th position of the inositol ring and inhibits AKT and PKC signaling by hydrolyzing of PI(3,4)P2 and PI(4,5)P2, respectively.	phosphoinositide-3,4-bisphosphate	132-141	inositol polyphosphate-4-phosphatase, type II	Mus musculus	0-6
32413098-2	2020	INPP4B dephosphorylates phospholipids at the 4th position of the inositol ring and inhibits AKT and PKC signaling by hydrolyzing of PI(3,4)P2 and PI(4,5)P2, respectively.	phosphoinositide-3,4-bisphosphate	132-141	thymoma viral proto-oncogene 1	Mus musculus	92-95
32198795-6	2020	In contrast to the case of SHP2, however, SHIP2 binds more strongly to EPIYA-C than to EPIYA-D. Interaction with CagA tethers SHIP2 to the plasma membrane, where it mediates production of phosphatidylinositol 3,4-diphosphate [PI(3,4)P2 ].	phosphoinositide-3,4-bisphosphate	226-235	inositol polyphosphate phosphatase-like 1	Mus musculus	42-47
32198795-6	2020	In contrast to the case of SHP2, however, SHIP2 binds more strongly to EPIYA-C than to EPIYA-D. Interaction with CagA tethers SHIP2 to the plasma membrane, where it mediates production of phosphatidylinositol 3,4-diphosphate [PI(3,4)P2 ].	phosphoinositide-3,4-bisphosphate	226-235	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	113-117
32198795-6	2020	In contrast to the case of SHP2, however, SHIP2 binds more strongly to EPIYA-C than to EPIYA-D. Interaction with CagA tethers SHIP2 to the plasma membrane, where it mediates production of phosphatidylinositol 3,4-diphosphate [PI(3,4)P2 ].	phosphoinositide-3,4-bisphosphate	226-235	inositol polyphosphate phosphatase-like 1	Mus musculus	126-131
32230859-7	2020	Our results suggest that hyperglycemia leads to: 1) A reduction in PI3P and PIP3, with increased PI4P that is later converted to PI(3,4)P2 at the cell surface in hormone receptor positive breast cancer; 2) a reduction in PI3P and PI4P with increased PIP3 surface expression in human epidermal growth factor receptor 2-positive (HER2+) breast cancer; and 3) an increase in di- and tri-phosphorylated PIs due to turnover of PI3P in triple negative breast cancer.	phosphoinositide-3,4-bisphosphate	129-138	nuclear receptor subfamily 4 group A member 1	Homo sapiens	162-178