PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25370932-3	2015	MCU can be opened by spermine under a physiological condition and inhibited by ruthenium red (RR).	Ruthenium Red	79-92	mitochondrial calcium uniporter	Rattus norvegicus	0-3
25370932-3	2015	MCU can be opened by spermine under a physiological condition and inhibited by ruthenium red (RR).	Ruthenium Red	94-96	mitochondrial calcium uniporter	Rattus norvegicus	0-3
26485022-14	2015	In addition, ruthenium red staining analysis showed that At1g74450 may affect the composition of the inner seed coat mucilage layer.	Ruthenium Red	13-26	BPS1-like protein (DUF793)	Arabidopsis thaliana	57-66
26294342-5	2015	KEY RESULTS: In mesenteric arteries, endothelium-dependent relaxation to both 2-AG and GSK was attenuated by structurally distinct TRPV4 antagonists, HC067047, RN1734 and ruthenium red.	Ruthenium Red	171-184	transient receptor potential cation channel subfamily V member 4	Homo sapiens	131-136
25409575-0	2015	Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red.	Ruthenium Red	107-120	potassium channel, subfamily K, member 2	Mus musculus	28-34
26207981-8	2015	The unselective TRP blocker ruthenium red (RR, 10 muM) was as efficient in inhibiting distension-induced CGRP release as the unselective antagonists of mechanogated DEG/ENaC (amiloride, 100 muM) and stretch-activated channels (gadolinium, 50 muM).	Ruthenium Red	28-41	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	105-109
25980432-6	2015	The general TRPV inhibitor ruthenium red at 15 and 50 mumol L(-1) reduced peak Cai by 41 +- 9 (P < 0.01; n = 5) and 77 +- 10% (P < 0.02; n = 6).	Ruthenium Red	27-40	carbonic anhydrase 1	Rattus norvegicus	79-82
26084216-10	2015	injection of the CB2 antagonist SR144528 or the vanilloid TRPV1 antagonist ruthenium red.	Ruthenium Red	75-88	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	58-63
25409575-0	2015	Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red.	Ruthenium Red	107-120	potassium channel, subfamily K, member 10	Mus musculus	36-42
25450352-2	2015	The present study demonstrates that the efflux of Ca2+ from rat liver mitochondria induced by ruthenium red, an inhibitor of the energy-dependent Ca2+ influx, seems to be partly due to the opening of Pal/Ca2+ pores.	Ruthenium Red	94-107	leucine-rich repeat, Ig-like and transmembrane domains 1	Rattus norvegicus	200-203
25409575-0	2015	Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red.	Ruthenium Red	107-120	potassium channel, subfamily K, member 4	Mus musculus	47-52
25729579-5	2015	In healthy EC, PAR2-dependent increases in the densities and firing rates of both forms of Ca(2+)-release were abolished by inositol 1,4,5- trisphosphate receptor (IP3R) inhibitor, but partially reduced by transient potential vanilloid channels inhibitor ruthenium red (RR).	Ruthenium Red	255-268	coagulation factor II (thrombin) receptor-like 1	Mus musculus	15-19
25729579-5	2015	In healthy EC, PAR2-dependent increases in the densities and firing rates of both forms of Ca(2+)-release were abolished by inositol 1,4,5- trisphosphate receptor (IP3R) inhibitor, but partially reduced by transient potential vanilloid channels inhibitor ruthenium red (RR).	Ruthenium Red	255-268	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	164-168
25729579-5	2015	In healthy EC, PAR2-dependent increases in the densities and firing rates of both forms of Ca(2+)-release were abolished by inositol 1,4,5- trisphosphate receptor (IP3R) inhibitor, but partially reduced by transient potential vanilloid channels inhibitor ruthenium red (RR).	Ruthenium Red	270-272	coagulation factor II (thrombin) receptor-like 1	Mus musculus	15-19
25729579-5	2015	In healthy EC, PAR2-dependent increases in the densities and firing rates of both forms of Ca(2+)-release were abolished by inositol 1,4,5- trisphosphate receptor (IP3R) inhibitor, but partially reduced by transient potential vanilloid channels inhibitor ruthenium red (RR).	Ruthenium Red	270-272	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	164-168
25640838-5	2015	MCU inhibition by ruthenium red (RuR) or MCU silencing by siRNA abolished serum-induced migration in MDA-MB-231 breast cancer cells and reduced serum- or thapsigargin (TG)-induced store-operated Ca2+ entry (SOCE).	Ruthenium Red	18-31	mitochondrial calcium uniporter	Homo sapiens	0-3
24815021-7	2014	Additionally, TRPA1 inhibitor, Ruthenium red (RR) and camphor, significantly blocked the enhanced production of NO and the rise of [Ca(2+)]c induced by AITC or cold stimulation, respectively.	Ruthenium Red	31-44	transient receptor potential cation channel subfamily A member 1	Homo sapiens	14-19
25372661-12	2015	Costimulation with HgCl2 (AQP inhibitor) and Ruthenium red (TRPV1 inhibitor) decreased cell viability with xylitol stimulation.	Ruthenium Red	45-58	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	60-65
24737248-7	2015	The enhanced desensitization of IGABA and the hump-like tail-I in PRIP-DKO PCs were mediated by increases in the intracellular Ca(2+) concentration and were largely abolished by a calcineurin inhibitor and ruthenium red.	Ruthenium Red	206-219	phospholipase C-like 1	Mus musculus	66-70
25268680-8	2015	They were also almost completely blocked by ruthenium red (1 muM) and SKF 96365 (250 muM), inhibitors of transient receptor potential vanilloid 2 (TRPV2) channels.	Ruthenium Red	44-57	latexin	Homo sapiens	61-64
25268680-8	2015	They were also almost completely blocked by ruthenium red (1 muM) and SKF 96365 (250 muM), inhibitors of transient receptor potential vanilloid 2 (TRPV2) channels.	Ruthenium Red	44-57	transient receptor potential cation channel subfamily V member 2	Homo sapiens	105-145
25268680-8	2015	They were also almost completely blocked by ruthenium red (1 muM) and SKF 96365 (250 muM), inhibitors of transient receptor potential vanilloid 2 (TRPV2) channels.	Ruthenium Red	44-57	transient receptor potential cation channel subfamily V member 2	Homo sapiens	147-152
25117291-7	2014	Capsaicin (CGRP depletor), capsazepine and ruthenium red (TRPV1 inhibitors) attenuated the PNS-induced decrease in pH and vasodilatation.	Ruthenium Red	43-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	58-63
25529443-4	2015	Therefore, we used two reagents ruthenium red (RR) and spermine (Sper) to inhibit MCU.	Ruthenium Red	32-45	mitochondrial calcium uniporter	Homo sapiens	82-85
25529443-4	2015	Therefore, we used two reagents ruthenium red (RR) and spermine (Sper) to inhibit MCU.	Ruthenium Red	47-49	mitochondrial calcium uniporter	Homo sapiens	82-85
24966090-7	2014	The TRPV4 antagonists, ruthenium red (15 mumol/l) and RN 1734 (10 mumol/l), blocked flow-induced NO production.	Ruthenium Red	23-36	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	4-9
24946182-5	2014	We also found that cyclosporine A plus ADP, as well as ruthenium red, a Ca(2+) uptake blocker, prevented these effects, suggesting the involvement of the mitochondrial permeability transition pore (mPTP) and an important role for Ca(2+), respectively.	Ruthenium Red	55-68	protein tyrosine phosphatase, receptor type, U	Mus musculus	198-202
24815021-7	2014	Additionally, TRPA1 inhibitor, Ruthenium red (RR) and camphor, significantly blocked the enhanced production of NO and the rise of [Ca(2+)]c induced by AITC or cold stimulation, respectively.	Ruthenium Red	46-48	transient receptor potential cation channel subfamily A member 1	Homo sapiens	14-19
25013893-7	2014	However, TGF-beta1-induced HSC-T6 cell proliferation was inhibited by Ruthenium Red (Ru) or synthetic siRNA targeting TRPV4, and this was accompanied by downregulation of myofibroblast markers including alpha-SMA and Col1alpha1.	Ruthenium Red	70-83	transforming growth factor, beta 1	Rattus norvegicus	9-18
25149175-4	2014	Both MCU (mitochondrial Ca2+ uniporter) knockdown and pretreatment with ruthenium red, an inhibitor of MCU, inhibited celastrol-induced mitochondrial Ca2+ uptake, dilation of mitochondria/ER, accumulation of poly-ubiquitinated proteins, and cell death in MDA-MB 435S cells.	Ruthenium Red	72-85	mitochondrial calcium uniporter	Homo sapiens	103-106
24920677-5	2014	Blockade of TRPM7 by 2-APB or TRPV4 by Ruthenium red inhibited shear stress-induced rise in [Ca(2+)]cyt in normal and IPAH-PASMC, while activation of TRPM7 by bradykinin or TRPV4 by 4alphaPDD induced greater increase in [Ca(2+)]cyt in IPAH-PASMC than in normal PASMC.	Ruthenium Red	39-52	transient receptor potential cation channel subfamily M member 7	Homo sapiens	12-17
24920677-5	2014	Blockade of TRPM7 by 2-APB or TRPV4 by Ruthenium red inhibited shear stress-induced rise in [Ca(2+)]cyt in normal and IPAH-PASMC, while activation of TRPM7 by bradykinin or TRPV4 by 4alphaPDD induced greater increase in [Ca(2+)]cyt in IPAH-PASMC than in normal PASMC.	Ruthenium Red	39-52	transient receptor potential cation channel subfamily V member 4	Homo sapiens	30-35
24787898-4	2014	In physiological extracellular Ca(2+), treatment with the MCU blocker, Ruthenium Red (RR), accelerated the Ca(2+) deregulation, most likely by disrupting mitochondrial Ca(2+) buffering and thus accelerating the lethal cytosolic Ca(2+) overload.	Ruthenium Red	71-84	mitochondrial calcium uniporter	Homo sapiens	58-61
24787898-4	2014	In physiological extracellular Ca(2+), treatment with the MCU blocker, Ruthenium Red (RR), accelerated the Ca(2+) deregulation, most likely by disrupting mitochondrial Ca(2+) buffering and thus accelerating the lethal cytosolic Ca(2+) overload.	Ruthenium Red	86-88	mitochondrial calcium uniporter	Homo sapiens	58-61
25013893-7	2014	However, TGF-beta1-induced HSC-T6 cell proliferation was inhibited by Ruthenium Red (Ru) or synthetic siRNA targeting TRPV4, and this was accompanied by downregulation of myofibroblast markers including alpha-SMA and Col1alpha1.	Ruthenium Red	70-72	transforming growth factor, beta 1	Rattus norvegicus	9-18
24405281-3	2014	The objective of this study was to determine whether inhalation of nanoparticles (NPs) containing the TRPV4 inhibitor ruthenium red (RR) prevents ventilator-induced lung edema in mice.	Ruthenium Red	118-131	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	102-107
24405281-3	2014	The objective of this study was to determine whether inhalation of nanoparticles (NPs) containing the TRPV4 inhibitor ruthenium red (RR) prevents ventilator-induced lung edema in mice.	Ruthenium Red	133-135	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	102-107
24863930-6	2014	Furthermore, a large conductance nonspecific cation channel, which was identified previously in the vesicle membrane and has biophysical properties similar to that of an RyR, is pharmacologically affected in a manner characteristic of an RyR: it is activated in the presence of the RyR agonist ryanodine (at low concentrations) and blocked by the RyR antagonist ruthenium red.	Ruthenium Red	362-375	ryanodine receptor 1, skeletal muscle	Mus musculus	170-173
24863930-6	2014	Furthermore, a large conductance nonspecific cation channel, which was identified previously in the vesicle membrane and has biophysical properties similar to that of an RyR, is pharmacologically affected in a manner characteristic of an RyR: it is activated in the presence of the RyR agonist ryanodine (at low concentrations) and blocked by the RyR antagonist ruthenium red.	Ruthenium Red	362-375	ryanodine receptor 1, skeletal muscle	Mus musculus	238-241
24863930-6	2014	Furthermore, a large conductance nonspecific cation channel, which was identified previously in the vesicle membrane and has biophysical properties similar to that of an RyR, is pharmacologically affected in a manner characteristic of an RyR: it is activated in the presence of the RyR agonist ryanodine (at low concentrations) and blocked by the RyR antagonist ruthenium red.	Ruthenium Red	362-375	ryanodine receptor 1, skeletal muscle	Mus musculus	238-241
24863930-6	2014	Furthermore, a large conductance nonspecific cation channel, which was identified previously in the vesicle membrane and has biophysical properties similar to that of an RyR, is pharmacologically affected in a manner characteristic of an RyR: it is activated in the presence of the RyR agonist ryanodine (at low concentrations) and blocked by the RyR antagonist ruthenium red.	Ruthenium Red	362-375	ryanodine receptor 1, skeletal muscle	Mus musculus	238-241
23707350-3	2013	Further experiments showed that the SNP-induced [Ca(2+)]c increase was specifically blocked by potent antagonists of the transient receptor potential vanilloid subtype 1 (TRPV1) channel: capsazepine, ruthenium red, and La(3+) in Ca(2+)-containing buffer.	Ruthenium Red	200-213	transient receptor potential cation channel subfamily V member 1	Homo sapiens	121-169
24057349-4	2014	The intracellular Ca(2+) transient activated by the TRPV2 activator probenecid was reversed or prevented by ruthenium red, a TRPV2 blocker.	Ruthenium Red	108-121	transient receptor potential cation channel subfamily V member 2	Homo sapiens	52-57
24057349-4	2014	The intracellular Ca(2+) transient activated by the TRPV2 activator probenecid was reversed or prevented by ruthenium red, a TRPV2 blocker.	Ruthenium Red	108-121	transient receptor potential cation channel subfamily V member 2	Homo sapiens	125-130
24467619-7	2014	Herein, we provide definitive proof of concept for this approach and report the first PAD inhibitor, ruthenium red (Ki of 17 muM), to preferentially bind the apoenzyme.	Ruthenium Red	101-114	latexin	Homo sapiens	125-128
24504097-3	2014	As predicted, transient receptor potential vanilloid 4 activation in the human airway produces contractions that are blocked by the nonselective transient receptor potential channel blocker ruthenium red.	Ruthenium Red	190-203	transient receptor potential cation channel subfamily V member 4	Homo sapiens	14-54
24586504-5	2014	NGCC-induced Ca(2+) influx was significantly attenuated by ruthenium red (RR; 30 microM), a non-specific blocker of TRP channels and capsazepine (CZP; 5 microM), a specific antagonist of TRPV1, implying that NGCC directly activates hTRPV1.	Ruthenium Red	59-72	transient receptor potential cation channel subfamily V member 1	Homo sapiens	187-192
24586504-5	2014	NGCC-induced Ca(2+) influx was significantly attenuated by ruthenium red (RR; 30 microM), a non-specific blocker of TRP channels and capsazepine (CZP; 5 microM), a specific antagonist of TRPV1, implying that NGCC directly activates hTRPV1.	Ruthenium Red	59-72	transient receptor potential cation channel subfamily V member 1	Homo sapiens	232-238
24586504-5	2014	NGCC-induced Ca(2+) influx was significantly attenuated by ruthenium red (RR; 30 microM), a non-specific blocker of TRP channels and capsazepine (CZP; 5 microM), a specific antagonist of TRPV1, implying that NGCC directly activates hTRPV1.	Ruthenium Red	74-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	187-192
24586504-5	2014	NGCC-induced Ca(2+) influx was significantly attenuated by ruthenium red (RR; 30 microM), a non-specific blocker of TRP channels and capsazepine (CZP; 5 microM), a specific antagonist of TRPV1, implying that NGCC directly activates hTRPV1.	Ruthenium Red	74-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	232-238
24085037-7	2014	Moreover, treatment with Ruthenium red, an inhibitor of mitochondrial Ca(2+) uptake, impairs Akt signaling without affecting mitochondrial dynamics.	Ruthenium Red	25-38	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
23994502-6	2013	Furthermore, stimulating A549 cells with known TRPA1 activators (i.e., allyl isothiocyanate) led to an increase in intracellular calcium levels, which was sensitive to the TRPA1 blocker ruthenium red.	Ruthenium Red	186-199	transient receptor potential cation channel subfamily A member 1	Homo sapiens	47-52
23994502-6	2013	Furthermore, stimulating A549 cells with known TRPA1 activators (i.e., allyl isothiocyanate) led to an increase in intracellular calcium levels, which was sensitive to the TRPA1 blocker ruthenium red.	Ruthenium Red	186-199	transient receptor potential cation channel subfamily A member 1	Homo sapiens	172-177
24510075-2	2014	Previous studies have reported that inhibition of MCU by ruthenium red (RR) protects the brain from ischemia/reperfusion (I/R) injury and that mitochondrial fission plays an important role in I/R injury.	Ruthenium Red	57-70	mitochondrial calcium uniporter	Rattus norvegicus	50-53
24510075-2	2014	Previous studies have reported that inhibition of MCU by ruthenium red (RR) protects the brain from ischemia/reperfusion (I/R) injury and that mitochondrial fission plays an important role in I/R injury.	Ruthenium Red	72-74	mitochondrial calcium uniporter	Rattus norvegicus	50-53
23402980-5	2013	TRPV1 non-competitive antagonist ruthenium red significantly decreased the permeability of capsaicin in M-S direction across colonic membrane.	Ruthenium Red	33-46	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
23828908-6	2013	In the presence of ruthenium red (a blocker of TRPV1, TRPV3, and TRPA1), the camphor sensitivity of cultured rat dorsal root ganglion neurons was highest in a subpopulation of cold- and icilin-sensitive neurons, strongly suggesting that camphor activates native TRPM8.	Ruthenium Red	19-32	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	47-52
23828908-6	2013	In the presence of ruthenium red (a blocker of TRPV1, TRPV3, and TRPA1), the camphor sensitivity of cultured rat dorsal root ganglion neurons was highest in a subpopulation of cold- and icilin-sensitive neurons, strongly suggesting that camphor activates native TRPM8.	Ruthenium Red	19-32	transient receptor potential cation channel, subfamily V, member 3	Rattus norvegicus	54-59
23828908-6	2013	In the presence of ruthenium red (a blocker of TRPV1, TRPV3, and TRPA1), the camphor sensitivity of cultured rat dorsal root ganglion neurons was highest in a subpopulation of cold- and icilin-sensitive neurons, strongly suggesting that camphor activates native TRPM8.	Ruthenium Red	19-32	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	65-70
23828908-6	2013	In the presence of ruthenium red (a blocker of TRPV1, TRPV3, and TRPA1), the camphor sensitivity of cultured rat dorsal root ganglion neurons was highest in a subpopulation of cold- and icilin-sensitive neurons, strongly suggesting that camphor activates native TRPM8.	Ruthenium Red	19-32	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	262-267
23900286-1	2013	Mitochondrial calcium uniporter (MCU) channel is responsible for Ruthenium Red-sensitive mitochondrial calcium uptake.	Ruthenium Red	65-78	mitochondrial calcium uniporter	Homo sapiens	0-31
23900286-1	2013	Mitochondrial calcium uniporter (MCU) channel is responsible for Ruthenium Red-sensitive mitochondrial calcium uptake.	Ruthenium Red	65-78	mitochondrial calcium uniporter	Homo sapiens	33-36
23755363-6	2013	Additionally, a classic feature of I MiCa , its sensitivity to ruthenium red inhibition, can be abolished by a point mutation in the putative pore domain without altering current magnitude.	Ruthenium Red	63-76	MHC class I polypeptide-related sequence A	Homo sapiens	37-41
23426506-2	2013	Inhibition of MCU by ruthenium red (RR) or Ru360 has previously been reported to protect against neuronal death.	Ruthenium Red	21-34	mitochondrial calcium uniporter	Rattus norvegicus	14-17
23426506-2	2013	Inhibition of MCU by ruthenium red (RR) or Ru360 has previously been reported to protect against neuronal death.	Ruthenium Red	36-38	mitochondrial calcium uniporter	Rattus norvegicus	14-17
23509974-4	2013	Ruthenium red stained amyloid plaques red under light microscopy, and exhibited birefringence under crossed polarizers when bound to Abeta plaques in brain tissue sections from the Tg2576 mouse model of AD.	Ruthenium Red	0-13	amyloid beta (A4) precursor protein	Mus musculus	133-138
23509974-7	2013	We further characterized the interaction of ruthenium red with synthetic Abeta fibrils using independent biophysical techniques.	Ruthenium Red	44-57	amyloid beta (A4) precursor protein	Mus musculus	73-78
23509974-8	2013	Ruthenium red exhibited birefringence and induced circular dichroic bands at 540 nm upon binding to Abeta fibrils due to induced chirality.	Ruthenium Red	0-13	amyloid beta (A4) precursor protein	Mus musculus	100-105
23644103-7	2013	Ruthenium red rescued MPP+-induced apoptosis and mitochondrial membrane potential reduction, reduced PARP cleavage, and inhibited the increase of mitochondrial matrix free Ca2+ in the cells exposed to MPP+.	Ruthenium Red	0-13	M-phase phosphoprotein 6	Homo sapiens	22-25
23644103-7	2013	Ruthenium red rescued MPP+-induced apoptosis and mitochondrial membrane potential reduction, reduced PARP cleavage, and inhibited the increase of mitochondrial matrix free Ca2+ in the cells exposed to MPP+.	Ruthenium Red	0-13	poly(ADP-ribose) polymerase 1	Homo sapiens	101-105
23644103-7	2013	Ruthenium red rescued MPP+-induced apoptosis and mitochondrial membrane potential reduction, reduced PARP cleavage, and inhibited the increase of mitochondrial matrix free Ca2+ in the cells exposed to MPP+.	Ruthenium Red	0-13	M-phase phosphoprotein 6	Homo sapiens	201-204
23470714-7	2013	The involvement of TRPV1 and TRPV4 in gentamicin trafficking of hair cells was confirmed by exogenous calcium treatment and TRPV inhibitors, including gadolinium and ruthenium red, which resulted in markedly inhibited GTTR uptake and gentamicin-induced hair cell damage in rodent and zebrafish ototoxic model systems.	Ruthenium Red	166-179	transient receptor potential cation channel, subfamily V, member 1	Danio rerio	19-24
23470714-7	2013	The involvement of TRPV1 and TRPV4 in gentamicin trafficking of hair cells was confirmed by exogenous calcium treatment and TRPV inhibitors, including gadolinium and ruthenium red, which resulted in markedly inhibited GTTR uptake and gentamicin-induced hair cell damage in rodent and zebrafish ototoxic model systems.	Ruthenium Red	166-179	transient receptor potential cation channel, subfamily V, member 4	Danio rerio	29-34
23307583-5	2013	These effects were completely abolished when neurons were preincubated with calcium-free bath solution or ruthenium-red (5 microM) and capsazepine (10 microM), suggesting the possibility of TRPV1 channel-activation by (-)-carvone.	Ruthenium Red	106-119	transient receptor potential cation channel subfamily V member 1	Homo sapiens	190-195
23345406-6	2013	Pharmacological inhibition of CALHM1 permeability using Ruthenium Red, Zn(2+), and Gd(3+), or expression of the CALHM1 N140A and W114A mutants, which are deficient in mediating Ca(2+) influx, prevented the effect of CALHM1 on the MEK, ERK, RSK and MSK signaling cascade, demonstrating that CALHM1 controlled this pathway via its channel properties.	Ruthenium Red	56-69	calcium homeostasis modulator 1	Mus musculus	30-36
23288842-7	2013	Removal of extracellular Ca(2+) and treatment with the TRPV4 antagonists Ruthenium Red or HC067047 prevented the sustained response.	Ruthenium Red	73-86	transient receptor potential cation channel subfamily V member 4	Homo sapiens	55-60
23386808-7	2013	The increase was reduced, but not blocked, by selective TRPV1 antagonists and in TRPV1 knockout mice; it was blocked completely by the broad-spectrum TRPV antagonist ruthenium red and by combined application of selective TRPV1 and TRPV4 antagonists.	Ruthenium Red	166-179	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	81-86
23111462-8	2013	In outside-out patch-clamp studies, currents were reduced by ruthenium red, a nonspecific inhibitor of TRPV5/V6 channels.	Ruthenium Red	61-74	transient receptor potential cation channel subfamily V member 5	Homo sapiens	103-108
23386808-7	2013	The increase was reduced, but not blocked, by selective TRPV1 antagonists and in TRPV1 knockout mice; it was blocked completely by the broad-spectrum TRPV antagonist ruthenium red and by combined application of selective TRPV1 and TRPV4 antagonists.	Ruthenium Red	166-179	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	81-86
24592736-3	2013	The channels were activated by removing Ca2+ and Mg2+ from surrounding solution, characterized by inward rectification, and were inactivated by the effective blocker of TRPV5 and TRPV6, ruthenium red.	Ruthenium Red	186-199	transient receptor potential cation channel subfamily V member 5	Homo sapiens	169-174
24592736-3	2013	The channels were activated by removing Ca2+ and Mg2+ from surrounding solution, characterized by inward rectification, and were inactivated by the effective blocker of TRPV5 and TRPV6, ruthenium red.	Ruthenium Red	186-199	transient receptor potential cation channel subfamily V member 6	Homo sapiens	179-184
22641084-4	2012	In wild-type mouse sensory neurons, H(2)S increased the intracellular Ca(2+) concentration ([Ca(2+)](i)), which was inhibited by ruthenium red (a nonselective TRP channel blocker) and HC-030031 (a TRPA1 blocker).	Ruthenium Red	129-142	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	197-202
23178883-7	2012	MCUR1 binds to MCU and regulates ruthenium-red-sensitive MCU-dependent Ca(2+) uptake.	Ruthenium Red	33-46	mitochondrial calcium uniporter regulator 1	Homo sapiens	0-5
23178883-7	2012	MCUR1 binds to MCU and regulates ruthenium-red-sensitive MCU-dependent Ca(2+) uptake.	Ruthenium Red	33-46	mitochondrial calcium uniporter	Homo sapiens	0-3
23178883-7	2012	MCUR1 binds to MCU and regulates ruthenium-red-sensitive MCU-dependent Ca(2+) uptake.	Ruthenium Red	33-46	mitochondrial calcium uniporter	Homo sapiens	15-18
22967106-6	2012	Moreover in the presence of antioxidants (PDTC, NAC) or calcium inhibitors (TMB-8, BAPTA-AM, Ruthenium Red), p27-induced activation of STAT-3 and NF-kappaB was dramatically reduced.	Ruthenium Red	93-106	transmembrane p24 trafficking protein 7	Homo sapiens	109-112
22967106-6	2012	Moreover in the presence of antioxidants (PDTC, NAC) or calcium inhibitors (TMB-8, BAPTA-AM, Ruthenium Red), p27-induced activation of STAT-3 and NF-kappaB was dramatically reduced.	Ruthenium Red	93-106	signal transducer and activator of transcription 3	Homo sapiens	135-141
22967106-6	2012	Moreover in the presence of antioxidants (PDTC, NAC) or calcium inhibitors (TMB-8, BAPTA-AM, Ruthenium Red), p27-induced activation of STAT-3 and NF-kappaB was dramatically reduced.	Ruthenium Red	93-106	nuclear factor kappa B subunit 1	Homo sapiens	146-155
23103857-7	2012	Antagonists of the store-operated Ca(2+) (SOC) channel (SKF96365 and ruthenium red) blocked both 2-APB-induced cell death and Ca(2+) influx, but those for transient receptor potential channels (BCTC, TRIM and BTP2), acid-sensing ion channels (amiloride) and proton-sensing G-protein-coupled receptors (U73122) did not.	Ruthenium Red	69-82	arginyl aminopeptidase	Rattus norvegicus	99-102
24009849-6	2012	KPEx-induced response to hTRPA1 was markedly attenuated by ruthenium red, a general blocker of TRP channels, and HC-030031, a specific antagonist of TRPA1.	Ruthenium Red	59-72	transient receptor potential cation channel subfamily A member 1	Homo sapiens	25-31
24009849-6	2012	KPEx-induced response to hTRPA1 was markedly attenuated by ruthenium red, a general blocker of TRP channels, and HC-030031, a specific antagonist of TRPA1.	Ruthenium Red	59-72	transient receptor potential cation channel subfamily A member 1	Homo sapiens	26-31
24009849-7	2012	In addition, the intracellular Ca(2+) influx attained with KPEx to hTRPV1 was mostly blocked by ruthenium red, and capsazepine, a specific antagonist of TRPV1.	Ruthenium Red	96-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-73
24009849-7	2012	In addition, the intracellular Ca(2+) influx attained with KPEx to hTRPV1 was mostly blocked by ruthenium red, and capsazepine, a specific antagonist of TRPV1.	Ruthenium Red	96-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
22622423-6	2012	TRPV3 inhibition by [Mg(2+)](o), the TRPV3 blocker ruthenium red, or TRPV3 siRNA suppressed this response.	Ruthenium Red	51-64	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	0-5
22622423-6	2012	TRPV3 inhibition by [Mg(2+)](o), the TRPV3 blocker ruthenium red, or TRPV3 siRNA suppressed this response.	Ruthenium Red	51-64	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	37-42
22622423-6	2012	TRPV3 inhibition by [Mg(2+)](o), the TRPV3 blocker ruthenium red, or TRPV3 siRNA suppressed this response.	Ruthenium Red	51-64	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	37-42
22314222-7	2012	Ruthenium red (a transient receptor potential vanilloid 1 (TRPV1) antagonist, 1muM) also significantly inhibited both phases of the response.	Ruthenium Red	0-13	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	17-57
22498929-6	2012	The increased nerve activity caused by capsaicin in DSS-1 and DSS-8 was significantly inhibited by pretreatment with ruthenium red, which is a nonselective inhibitor of TRP channels of unmyelinated C-fibers (nociceptors).	Ruthenium Red	117-130	SEM1 26S proteasome subunit	Rattus norvegicus	52-57
22787041-8	2012	Moreover, ruthenium red (a general TRP channel blocker), BTP2 (a general TRPC channel inhibitor), and pyrazole-3 (a selective TRPC3 blocker) each potently inhibited the I(IC).	Ruthenium Red	10-23	transient receptor potential cation channel, subfamily C, member 3	Rattus norvegicus	126-131
22724881-8	2012	RESULTS: Capsaicin (1 - 100 nM) caused a dose-dependent inhibition of motility manifested as an increase in the interval between motor complexes (MCs) in the WT animal only, a response abolished by pre-treatment with TRPV1 antagonist capsazepine (Capz), ruthenium red (RR), and L-NAME.	Ruthenium Red	254-267	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	217-222
22724881-8	2012	RESULTS: Capsaicin (1 - 100 nM) caused a dose-dependent inhibition of motility manifested as an increase in the interval between motor complexes (MCs) in the WT animal only, a response abolished by pre-treatment with TRPV1 antagonist capsazepine (Capz), ruthenium red (RR), and L-NAME.	Ruthenium Red	269-271	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	217-222
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Ruthenium Red	206-219	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Ruthenium Red	206-219	transient receptor potential cation channel subfamily V member 4	Homo sapiens	128-133
22365750-6	2012	The later, pointed to a possible involvement of transient receptor potential vanilloid 4 (TRPV4), and indeed, administration of ruthenium red, a TRPV4 blocker, resulted in a sharp rise in BP.	Ruthenium Red	128-141	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	48-88
22365750-6	2012	The later, pointed to a possible involvement of transient receptor potential vanilloid 4 (TRPV4), and indeed, administration of ruthenium red, a TRPV4 blocker, resulted in a sharp rise in BP.	Ruthenium Red	128-141	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	90-95
22365750-6	2012	The later, pointed to a possible involvement of transient receptor potential vanilloid 4 (TRPV4), and indeed, administration of ruthenium red, a TRPV4 blocker, resulted in a sharp rise in BP.	Ruthenium Red	128-141	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	145-150
22378774-7	2012	A functional assay with CHO-K1 cells showed that tilapia TRPV4 responded to a decrease in extracellular osmolality, and that its function was suppressed by ruthenium red (RR) and activated by 4alpha-phorbol 12,13-didecanoate (4aPDD).	Ruthenium Red	156-169	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4	Cricetulus griseus	57-62
22378774-7	2012	A functional assay with CHO-K1 cells showed that tilapia TRPV4 responded to a decrease in extracellular osmolality, and that its function was suppressed by ruthenium red (RR) and activated by 4alpha-phorbol 12,13-didecanoate (4aPDD).	Ruthenium Red	171-173	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4	Cricetulus griseus	57-62
22314222-7	2012	Ruthenium red (a transient receptor potential vanilloid 1 (TRPV1) antagonist, 1muM) also significantly inhibited both phases of the response.	Ruthenium Red	0-13	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	59-64
22209849-8	2012	Furthermore, D7-induced [Ca(2+)](c) was found to alter mitochondrial membrane potential and induce cytochrome c release, which was inhibited by either Bapta-AM or ruthenium red (an inhibitor of mitochondrial Ca(2+) uniporter).	Ruthenium Red	163-176	cytochrome c, somatic	Homo sapiens	99-111
21484933-8	2012	By contrast, STP(DHEAS) was totally inhibited by either the metabotropic glutamate receptor 5 (mGluR5) antagonist MPEP (10 muM) or the ryanodine receptor (RyR) inhibitors (ryanodine and ruthenium red), but not by the mGluR1 antagonist LY367385 and the IP3R antagonist 2-APB, suggesting that STP(DHEAS) is mediated by an mGluR5-RyR cascade in postsynaptic neurons.	Ruthenium Red	186-199	thyroid hormone receptor interactor 10	Rattus norvegicus	13-16
21484933-8	2012	By contrast, STP(DHEAS) was totally inhibited by either the metabotropic glutamate receptor 5 (mGluR5) antagonist MPEP (10 muM) or the ryanodine receptor (RyR) inhibitors (ryanodine and ruthenium red), but not by the mGluR1 antagonist LY367385 and the IP3R antagonist 2-APB, suggesting that STP(DHEAS) is mediated by an mGluR5-RyR cascade in postsynaptic neurons.	Ruthenium Red	186-199	sulfotransferase family 2A member 1	Homo sapiens	17-22
22343900-4	2012	Here we show that Drosophila melanogaster Piezo (DmPiezo, also called CG8486) also induces mechanically activated currents in cells, but through channels with remarkably distinct pore properties including sensitivity to the pore blocker ruthenium red and single channel conductances.	Ruthenium Red	237-250	piezo	Drosophila melanogaster	42-47
22343900-4	2012	Here we show that Drosophila melanogaster Piezo (DmPiezo, also called CG8486) also induces mechanically activated currents in cells, but through channels with remarkably distinct pore properties including sensitivity to the pore blocker ruthenium red and single channel conductances.	Ruthenium Red	237-250	piezo	Drosophila melanogaster	49-56
22419111-6	2012	The anion-channel inhibitor 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS) protects isolated mitochondria against Tat-induced mitochondrial membrane permeabilization (MMP), whereas ruthenium red, a ryanodine receptor blocker, does not.	Ruthenium Red	190-203	tyrosine aminotransferase	Homo sapiens	123-126
22226146-7	2012	fMLP further increased [Ca(2+)](pm) in this region, which was abolished by a TRPV2 inhibitor ruthenium red.	Ruthenium Red	93-106	transient receptor potential cation channel, subfamily V, member 2	Mus musculus	77-82
21574765-6	2012	A characteristic of TRPV2 is its activation by high noxious temperature; temperatures exceeding 50  C induced a similar ruthenium-red-sensitive current.	Ruthenium Red	120-133	transient receptor potential cation channel subfamily V member 2	Homo sapiens	20-25
22078634-6	2012	Both xestospongin C, a specific inhibitor of inositol 1,4,5-triphosphate receptors (IP(3)R), and ryanodine or ruthenium red, inhibitors of RyR, partially blocked LTD4-induced Ca(2+) oscillations.	Ruthenium Red	110-123	ryanodine receptor 1	Homo sapiens	139-142
23365602-7	2012	We show that TRPV1 can functionally be expressed in the oocyte by (a) activation by capsaicin (K(1/2) = 1.1 muM), (b) activation by temperatures exceeding 42 C, (c) activation by reduced pH (from 7.4 to 6.2), and (d) inhibition by ruthenium red.	Ruthenium Red	231-244	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	13-18
22514663-2	2012	Recent findings indicate CCK acts on these neurons via a ruthenium red (RuR) sensitive pathway that involves members of the vanilloid (V) subfamily of transient receptor potential (TRP) channels.	Ruthenium Red	57-70	cholecystokinin	Mus musculus	25-28
22761937-7	2012	Additionally, adult hippocampal astrocytes in slices or cultured hippocampal astrocytes respond to the TRPV4 activator 4-alpha-phorbol-12,-13-didecanoate (4alphaPDD) by an increase in intracellular calcium and the activation of a cationic current, both of which are abolished by the removal of extracellular calcium or exposure to TRP antagonists, such as Ruthenium Red or RN1734.	Ruthenium Red	356-369	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	103-108
22514663-2	2012	Recent findings indicate CCK acts on these neurons via a ruthenium red (RuR) sensitive pathway that involves members of the vanilloid (V) subfamily of transient receptor potential (TRP) channels.	Ruthenium Red	72-75	cholecystokinin	Mus musculus	25-28
21841185-7	2012	A key role for airway sensory neuronal reflexes in the LAR was therefore hypothesised, which was confirmed by the blockade observed after administration of ruthenium red (non-selective cation channel blocker), HC-030031 (TRPA1 inhibitor) and tiotropium bromide (anticholinergic) but not JNJ-17203212 (TRPV1 inhibitor).	Ruthenium Red	156-169	low antibody response	Mus musculus	55-58
21986204-10	2011	When the ryanodine receptor (RyR) was completely inhibited with ruthenium red (50 muM), changes in [Ca(2+)](i) between 50 and 350 nM did not produce any significant effect on SR Ca(2+) leak, indicating that [Ca(2+)](i) alters SR Ca(2+) leak solely by regulating RyR activity.	Ruthenium Red	64-77	LOC100009439	Oryctolagus cuniculus	9-27
21883699-8	2011	These [Ca(2+) ](i) increases were potently inhibited by ruthenium red (RuR), a TRPV4 channel antagonist, and were suppressed by extracellular protons (pH 5.0).	Ruthenium Red	56-69	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	79-84
21867704-8	2011	However, the non-selective TRP channel blocker, ruthenium red (30 muM) was a more effective inhibitor, reducing the effects of OA-NO(2) on basal tone by 75% and the effects on phasic amplitude by 85%.	Ruthenium Red	48-61	latexin	Homo sapiens	66-69
21883699-8	2011	These [Ca(2+) ](i) increases were potently inhibited by ruthenium red (RuR), a TRPV4 channel antagonist, and were suppressed by extracellular protons (pH 5.0).	Ruthenium Red	71-74	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	79-84
21506114-6	2011	In fura2-loaded HCEC, a TRPV1-3 selective agonist, 100 microM 2-aminoethoxydiphenyl borate (2-APB), induced intracellular Ca(2+) transients and an increase in non-selective cation outward currents that were suppressed by ruthenium-red (RuR) (10-20 microM), a non-selective TRPV channel blocker.	Ruthenium Red	221-234	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
21575626-6	2011	Ruthenium red, a general TRP antagonist, deteriorated acidosis-promoted TRAP+LMNC formation.	Ruthenium Red	0-13	lamin A/C	Homo sapiens	77-81
21786199-6	2011	The mitochondrial Ca(2+) uptake sensitive to non-specific inhibitors ruthenium red and Ru360 has long been considered as the activity of mitochondrial Ca(2+) uniporter (MCU).	Ruthenium Red	69-82	mitochondrial calcium uniporter	Homo sapiens	169-172
21506114-6	2011	In fura2-loaded HCEC, a TRPV1-3 selective agonist, 100 microM 2-aminoethoxydiphenyl borate (2-APB), induced intracellular Ca(2+) transients and an increase in non-selective cation outward currents that were suppressed by ruthenium-red (RuR) (10-20 microM), a non-selective TRPV channel blocker.	Ruthenium Red	236-239	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
21562271-7	2011	RGC responses to TRPV4-selective agonists and hypotonic stimulation were absent in Ca2+ -free saline and were antagonized by the nonselective TRP channel antagonists Ruthenium Red and gadolinium, but were unaffected by the TRPV1 antagonist capsazepine.	Ruthenium Red	166-179	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	17-22
21466812-6	2011	The edema and cellular infiltration evoked by the application of 4mug/ear of cinnamaldehyde were prevented by topical application of ruthenium red, a non-selective TRP antagonist as well as camphor and HC030031, two TRPA1 receptor antagonists.	Ruthenium Red	133-146	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	216-221
21339821-4	2011	GSK101 (10 nM) causes a TRPV4 specific Ca(2+) influx in HeLa-TRPV4 cells, but not in control transfected cells, which can be inhibited by ruthenium red and Ca(2+)-free medium more significantly at the early stage of the activation rather than the late stage, reflecting apparent partial desensitization.	Ruthenium Red	138-151	transient receptor potential cation channel subfamily V member 4	Homo sapiens	24-29
21315802-4	2011	We found that ruthenium red (RR; a nonselective TRP inhibitor) and AP18 (a TRPA1 antagonist) significantly increased scratching bouts caused by ET-1, while capsazepine (a TRPV1 antagonist) and morphine showed no effects in the ET-1-induced scratching response.	Ruthenium Red	14-27	endothelin 1	Homo sapiens	144-148
21315802-4	2011	We found that ruthenium red (RR; a nonselective TRP inhibitor) and AP18 (a TRPA1 antagonist) significantly increased scratching bouts caused by ET-1, while capsazepine (a TRPV1 antagonist) and morphine showed no effects in the ET-1-induced scratching response.	Ruthenium Red	14-27	transient receptor potential cation channel subfamily V member 1	Homo sapiens	171-176
21315802-4	2011	We found that ruthenium red (RR; a nonselective TRP inhibitor) and AP18 (a TRPA1 antagonist) significantly increased scratching bouts caused by ET-1, while capsazepine (a TRPV1 antagonist) and morphine showed no effects in the ET-1-induced scratching response.	Ruthenium Red	14-27	endothelin 1	Homo sapiens	227-231
21315802-4	2011	We found that ruthenium red (RR; a nonselective TRP inhibitor) and AP18 (a TRPA1 antagonist) significantly increased scratching bouts caused by ET-1, while capsazepine (a TRPV1 antagonist) and morphine showed no effects in the ET-1-induced scratching response.	Ruthenium Red	29-31	endothelin 1	Homo sapiens	144-148
21315802-4	2011	We found that ruthenium red (RR; a nonselective TRP inhibitor) and AP18 (a TRPA1 antagonist) significantly increased scratching bouts caused by ET-1, while capsazepine (a TRPV1 antagonist) and morphine showed no effects in the ET-1-induced scratching response.	Ruthenium Red	29-31	endothelin 1	Homo sapiens	227-231
21266172-10	2011	This effect was significantly attenuated by previous exposure to ruthenium red (10muM), non-specific TRP channels blocker, high concentration of menthol (300muM) and HC-030031 (10muM), which are known to antagonize the effects of TRPA1 agonists.	Ruthenium Red	65-78	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	230-235
21339821-4	2011	GSK101 (10 nM) causes a TRPV4 specific Ca(2+) influx in HeLa-TRPV4 cells, but not in control transfected cells, which can be inhibited by ruthenium red and Ca(2+)-free medium more significantly at the early stage of the activation rather than the late stage, reflecting apparent partial desensitization.	Ruthenium Red	138-151	transient receptor potential cation channel subfamily V member 4	Homo sapiens	56-66
21184651-3	2011	In this laboratory, our in vitro experimental results show that polycationic anticoagulants (compound 48/80, ruthenium red, polybrene, protamine, Buforin I, and cationic polyamino acids) intervene TF hypercoagulability at posttranslational level.	Ruthenium Red	109-122	coagulation factor III, tissue factor	Homo sapiens	197-199
20881249-8	2010	Ruthenium red, an inhibitor of the TRPV family and TRPA1, blocked both depolarizing responses to CCK and CCK-induced calcium increases, but had no effect on the KCl-induced calcium response.	Ruthenium Red	0-13	transient receptor potential cation channel subfamily A member 1	Homo sapiens	51-56
20920578-7	2010	The RyR antagonist ruthenium red inhibited xanthine oxidase-induced potentiation, while the RyR agonist caffeine elevated diaphragm twitch and low-frequency tension in a non-additive manner by 55% when introduced simultaneously with ROS challenge.	Ruthenium Red	19-32	ryanodine receptor 2	Rattus norvegicus	4-7
20980052-6	2010	TRPV inhibitor ruthenium red and tetracycline-induced TRPV2 silencing significantly decreased both the frequency of Ca(2+) oscillations and the transient inward currents in RANKL-treated preosteoclasts.	Ruthenium Red	15-28	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	173-178
21461241-8	2011	However, peak [Ca(2+)](i) was only observed after the first caffeine stimulation in Ca(2+) free buffer and this increase was markedly blocked by ruthenium red, a RyR blocker.	Ruthenium Red	145-158	ryanodine receptor 2	Rattus norvegicus	162-165
20923851-4	2011	In the presence of ruthenium red (inhibitor of RyRs), CGP decreased SERCA-mediated Ca2+ uptake of cardiac and skeletal sarcoplasmic reticulum (SR) microsomes (IC50 values of 6.6 and 9.9 muM, respectively).	Ruthenium Red	19-32	latexin	Homo sapiens	186-189
20881249-8	2010	Ruthenium red, an inhibitor of the TRPV family and TRPA1, blocked both depolarizing responses to CCK and CCK-induced calcium increases, but had no effect on the KCl-induced calcium response.	Ruthenium Red	0-13	cholecystokinin	Homo sapiens	97-100
20881249-8	2010	Ruthenium red, an inhibitor of the TRPV family and TRPA1, blocked both depolarizing responses to CCK and CCK-induced calcium increases, but had no effect on the KCl-induced calcium response.	Ruthenium Red	0-13	cholecystokinin	Homo sapiens	105-108
20539001-8	2010	These effects were both sensitive to the TRPV channel blocker ruthenium red (20 muM).	Ruthenium Red	62-75	latexin	Homo sapiens	80-83
20439439-3	2010	Transient receptor potential vanilloid 1 (TRPV1) agonists dilated guinea pig ileal submucosal arterioles and were blocked by capsazepine and ruthenium red.	Ruthenium Red	141-154	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	0-40
20717636-8	2010	Cold-induced colonic contractions were specially inhibited by TRPA1 blocker, ruthenium red (30 mumol/L), in the proximal and distal colon (P<0.05).	Ruthenium Red	77-90	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	62-67
20439439-3	2010	Transient receptor potential vanilloid 1 (TRPV1) agonists dilated guinea pig ileal submucosal arterioles and were blocked by capsazepine and ruthenium red.	Ruthenium Red	141-154	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	42-47
20214874-5	2010	Ruthenium red (RuR), AzRu, DIDS and hexokinase-I (HK-I), all known to interact with VDAC, inhibited the release of cytochrome c, Smac/Diablo and AIF, while RuR-mediated inhibition was not observed in cells expressing RuR-insensitive E72Q-VDAC1.	Ruthenium Red	0-13	hexokinase 1	Homo sapiens	50-54
20546877-3	2010	The calcium permeability of TRPV2 channels in T24 cells was investigated using a calcium imaging assay that used cannabidiol (CBD), a relatively selective TRPV2 agonist, and ruthenium red (RuR), a nonselective TRPV channel antagonist.	Ruthenium Red	174-187	transient receptor potential cation channel subfamily V member 2	Homo sapiens	28-33
20546877-3	2010	The calcium permeability of TRPV2 channels in T24 cells was investigated using a calcium imaging assay that used cannabidiol (CBD), a relatively selective TRPV2 agonist, and ruthenium red (RuR), a nonselective TRPV channel antagonist.	Ruthenium Red	189-192	transient receptor potential cation channel subfamily V member 2	Homo sapiens	28-33
20453127-5	2010	Transmission electron microscopy showed that a layered structure at the cell surface, stainable with ruthenium red, was impaired in the SO3177 mutant (DeltaSO3177), confirming that SO3177 is involved in the biosynthesis of cell surface polysaccharides.	Ruthenium Red	101-114	formyl transferase	Shewanella oneidensis MR-1	136-142
20214874-5	2010	Ruthenium red (RuR), AzRu, DIDS and hexokinase-I (HK-I), all known to interact with VDAC, inhibited the release of cytochrome c, Smac/Diablo and AIF, while RuR-mediated inhibition was not observed in cells expressing RuR-insensitive E72Q-VDAC1.	Ruthenium Red	0-13	cytochrome c, somatic	Homo sapiens	115-127
20214874-5	2010	Ruthenium red (RuR), AzRu, DIDS and hexokinase-I (HK-I), all known to interact with VDAC, inhibited the release of cytochrome c, Smac/Diablo and AIF, while RuR-mediated inhibition was not observed in cells expressing RuR-insensitive E72Q-VDAC1.	Ruthenium Red	0-13	diablo IAP-binding mitochondrial protein	Homo sapiens	129-133
20214874-5	2010	Ruthenium red (RuR), AzRu, DIDS and hexokinase-I (HK-I), all known to interact with VDAC, inhibited the release of cytochrome c, Smac/Diablo and AIF, while RuR-mediated inhibition was not observed in cells expressing RuR-insensitive E72Q-VDAC1.	Ruthenium Red	0-13	diablo IAP-binding mitochondrial protein	Homo sapiens	134-140
20214874-5	2010	Ruthenium red (RuR), AzRu, DIDS and hexokinase-I (HK-I), all known to interact with VDAC, inhibited the release of cytochrome c, Smac/Diablo and AIF, while RuR-mediated inhibition was not observed in cells expressing RuR-insensitive E72Q-VDAC1.	Ruthenium Red	0-13	apoptosis inducing factor mitochondria associated 1	Homo sapiens	145-148
20214874-5	2010	Ruthenium red (RuR), AzRu, DIDS and hexokinase-I (HK-I), all known to interact with VDAC, inhibited the release of cytochrome c, Smac/Diablo and AIF, while RuR-mediated inhibition was not observed in cells expressing RuR-insensitive E72Q-VDAC1.	Ruthenium Red	0-13	voltage dependent anion channel 1	Homo sapiens	238-243
20071675-12	2010	In contrast, ryanodine receptor (RyR) antagonist ruthenium red (10 microM) or dantrolene (25 microM) inhibited the HP-induced calcium increase.	Ruthenium Red	49-62	ryanodine receptor 2	Rattus norvegicus	13-31
20572856-6	2010	Inhibition of TRPV4 with ruthenium red impaired both ATP- and carbachol-stimulated Ca(2+) signals.	Ruthenium Red	25-38	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	14-19
20071675-12	2010	In contrast, ryanodine receptor (RyR) antagonist ruthenium red (10 microM) or dantrolene (25 microM) inhibited the HP-induced calcium increase.	Ruthenium Red	49-62	ryanodine receptor 2	Rattus norvegicus	33-36
20071675-15	2010	The magnitude of the ERK1/2 phosphorylation response was reduced by ruthenium red and dantrolene.	Ruthenium Red	68-81	mitogen activated protein kinase 3	Rattus norvegicus	21-27
20194297-4	2010	Depressor effects of 4alpha-phorbol-12,13-didecanoate but not dihydrocapsaicin (a selective TRPV1 agonist; 30 microg/kg IV) were abolished by ruthenium red (a TRPV4 antagonist; 3 mg/kg IV) in all of the groups.	Ruthenium Red	142-155	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	159-164
20405023-17	2010	In live-cell imaging experiments, [Ca(2+)](i) was lower in the presence of the TRPV5/TRPV6 inhibitor ruthenium red.	Ruthenium Red	101-114	transient receptor potential cation channel subfamily V member 5	Homo sapiens	79-84
20405023-17	2010	In live-cell imaging experiments, [Ca(2+)](i) was lower in the presence of the TRPV5/TRPV6 inhibitor ruthenium red.	Ruthenium Red	101-114	transient receptor potential cation channel subfamily V member 6	Homo sapiens	85-90
20194297-5	2010	Blockade of TRPV4 with ruthenium red increased mean arterial pressure in DR-HS rats only (P<0.05).	Ruthenium Red	23-36	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	12-17
21472222-4	2010	RyR activity is inhibited by Mg2+, ruthenium red, or higher concentrations (>=100 microM) of ryanodine.	Ruthenium Red	35-48	ryanodine receptor 1	Homo sapiens	0-3
19966050-7	2010	Using a fura-2/Mn(2+) quenching assay, shear was observed to produce rapid Ca(2+) influx in endothelial cells, which was markedly inhibited by the TRPV4 channel blocker ruthenium red and TRPV4-specific short interfering RNA.	Ruthenium Red	169-182	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	147-152
20064552-7	2010	Blockers of TRPV4 channels (Gd(3+) 500 microM; Ruthenium red 1 microM) increased the viability of astrocytes following MCS or BSO treatments, consistent with the expression pattern of these channels.	Ruthenium Red	47-60	transient receptor potential cation channel subfamily V member 4	Homo sapiens	12-17
19961905-12	2010	In addition, block of the TRPA1 channel with Ruthenium Red did not inhibit cold evoked activity in either cinnamaldehyde sensitive or insensitive cold responsive nociceptors.	Ruthenium Red	45-58	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	26-31
19961905-13	2010	In cinnamaldehyde-sensitive-cold-sensitive afferents, although TRPA1 agonist-evoked activity was totally abolished by Ruthenium Red, cold evoked activity was unaffected by channel blockade.	Ruthenium Red	118-131	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	63-68
19966050-7	2010	Using a fura-2/Mn(2+) quenching assay, shear was observed to produce rapid Ca(2+) influx in endothelial cells, which was markedly inhibited by the TRPV4 channel blocker ruthenium red and TRPV4-specific short interfering RNA.	Ruthenium Red	169-182	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	187-192
19683814-3	2009	In PMA-stimulated microglia, ROS production was substantially reduced upon inhibition of the non-selective cation channel TRPV1 with La(3+), ruthenium red, capsazepine and 5-iodo-resinferatoxin.	Ruthenium Red	141-154	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
19463684-7	2009	This rise was significantly prevented when cells were pre-treated with ruthenium red and completely abolished in cells treated with siRNA specifically targeting TRPV5.These data demonstrate for the first time, a novel rapid modulation of endogenously expressed TRPV5 channels by E(2) in kidney cells.	Ruthenium Red	71-84	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	161-166
19507004-4	2009	The effects of these TRPA1 agonists were inhibited by ruthenium red, a TRPA1 antagonist, and TRPA1-specific siRNA.	Ruthenium Red	54-67	transient receptor potential cation channel subfamily A member 1	Homo sapiens	21-26
19576208-8	2009	The effects of AITC were inhibited by ruthenium red, a TRPA1 antagonist.	Ruthenium Red	38-51	transient receptor potential cation channel subfamily A member 1	Canis lupus familiaris	55-60
19463684-7	2009	This rise was significantly prevented when cells were pre-treated with ruthenium red and completely abolished in cells treated with siRNA specifically targeting TRPV5.These data demonstrate for the first time, a novel rapid modulation of endogenously expressed TRPV5 channels by E(2) in kidney cells.	Ruthenium Red	71-84	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	261-266
19411839-5	2009	Whole-cell patch-clamp recordings with the TRPV4 agonist, GSK1016790A, activated urothelial currents with an EC(50) of 11 nM that were completely inhibited by the TRPV4 inhibitor ruthenium red (5 microM).	Ruthenium Red	179-192	transient receptor potential cation channel subfamily V member 4	Cavia porcellus	43-48
19404626-7	2009	Ruthenium red, a water soluble polycationic dye, was found to block the pore of the capsaicin-operated cation channel TRPV1 thus interfering with all polymodal ways of TRPV1 activation.	Ruthenium Red	0-13	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	118-123
19404626-7	2009	Ruthenium red, a water soluble polycationic dye, was found to block the pore of the capsaicin-operated cation channel TRPV1 thus interfering with all polymodal ways of TRPV1 activation.	Ruthenium Red	0-13	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	168-173
19295174-6	2009	Single-channel patch-clamp experiments demonstrated the presence of inwardly rectifying monovalent currents that displayed kinetic characteristics of unitary TRPV5 and/or TRPV6 currents and were blocked by extracellular Ca(2+) and ruthenium red.	Ruthenium Red	231-244	transient receptor potential cation channel subfamily V member 5	Homo sapiens	158-163
19295174-6	2009	Single-channel patch-clamp experiments demonstrated the presence of inwardly rectifying monovalent currents that displayed kinetic characteristics of unitary TRPV5 and/or TRPV6 currents and were blocked by extracellular Ca(2+) and ruthenium red.	Ruthenium Red	231-244	transient receptor potential cation channel subfamily V member 6	Homo sapiens	171-176
19206161-5	2009	UV irradiation induced slow and persistent calcium influx and increased membrane current, which was inhibited by TRPV1 inhibitors (capsazepine and ruthenium red).	Ruthenium Red	147-160	transient receptor potential cation channel subfamily V member 1	Homo sapiens	113-118
19398664-11	2009	Current properties reveal that the mCa1 channel underlies the human MCU and that the mCa2 channel is responsible for the ruthenium red-insensitive/low-sensitivity non-MCU-type mitochondrial Ca(2+) uptake.	Ruthenium Red	121-134	carbonic anhydrase 2	Mus musculus	85-89
19473241-6	2009	The TRPV1 antagonists ruthenium red and N-(4-t-butylphenyl)-4-(3-chloropyridin-2-yl) tetrahydropyrazine-1(2H)-carboxamide were ineffective on the basal heat response.	Ruthenium Red	22-35	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	4-9
19411839-5	2009	Whole-cell patch-clamp recordings with the TRPV4 agonist, GSK1016790A, activated urothelial currents with an EC(50) of 11 nM that were completely inhibited by the TRPV4 inhibitor ruthenium red (5 microM).	Ruthenium Red	179-192	transient receptor potential cation channel subfamily V member 4	Cavia porcellus	163-168
19166511-9	2009	Co-expression of both mutant Pink1 and alpha-syn led to alterations in mitochondrial structure and neurite outgrowth that were partially ameliorated by treatment with cyclosporine A, and completely restored by treatment with the mitochondrial calcium influx blocker Ruthenium Red, but not with other cellular calcium flux blockers.	Ruthenium Red	266-279	PTEN induced kinase 1	Homo sapiens	29-34
19188524-5	2009	In small mesenteric arteries from wild-type mice, the TRPV4 activator 4alpha-phorbol-12,13-didecanoate increased endothelial [Ca2+]i in situ, which was reversed by the TRPV4 blocker ruthenium red.	Ruthenium Red	182-195	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	54-59
19188524-5	2009	In small mesenteric arteries from wild-type mice, the TRPV4 activator 4alpha-phorbol-12,13-didecanoate increased endothelial [Ca2+]i in situ, which was reversed by the TRPV4 blocker ruthenium red.	Ruthenium Red	182-195	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	168-173
19166511-9	2009	Co-expression of both mutant Pink1 and alpha-syn led to alterations in mitochondrial structure and neurite outgrowth that were partially ameliorated by treatment with cyclosporine A, and completely restored by treatment with the mitochondrial calcium influx blocker Ruthenium Red, but not with other cellular calcium flux blockers.	Ruthenium Red	266-279	synuclein alpha	Homo sapiens	39-48
18751681-0	2009	Ruthenium red protects HepG2 cells overexpressing CYP2E1 against acetaminophen cytotoxicity.	Ruthenium Red	0-13	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	50-56
19167822-4	2009	Both cross-organ reflex sensitization and increments in protein expression were reversed by intra-colonic pretreatments with ruthenium red (a non-selective transient receptor potential vanilloid, TRPV, antagonist), capsaizepine (a TRPV1-selective antagonist), lidocaine (a nerve conduction blocker) as well as by the intra-thecal pretreatment with APV (a NRMDR antagonist) Co-101244 (a NR2B-selective antagonist) and roscovitine (a Cdk5 antagonist).	Ruthenium Red	125-138	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	231-236
19167822-4	2009	Both cross-organ reflex sensitization and increments in protein expression were reversed by intra-colonic pretreatments with ruthenium red (a non-selective transient receptor potential vanilloid, TRPV, antagonist), capsaizepine (a TRPV1-selective antagonist), lidocaine (a nerve conduction blocker) as well as by the intra-thecal pretreatment with APV (a NRMDR antagonist) Co-101244 (a NR2B-selective antagonist) and roscovitine (a Cdk5 antagonist).	Ruthenium Red	125-138	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	386-390
19167822-4	2009	Both cross-organ reflex sensitization and increments in protein expression were reversed by intra-colonic pretreatments with ruthenium red (a non-selective transient receptor potential vanilloid, TRPV, antagonist), capsaizepine (a TRPV1-selective antagonist), lidocaine (a nerve conduction blocker) as well as by the intra-thecal pretreatment with APV (a NRMDR antagonist) Co-101244 (a NR2B-selective antagonist) and roscovitine (a Cdk5 antagonist).	Ruthenium Red	125-138	cyclin-dependent kinase 5	Rattus norvegicus	432-436
18682435-7	2008	The TRPV4-channel inhibitor ruthenium red (RuR) inhibited the EDHF-mediated flow response, but the combination of MS-PPOH and RuR had no further effect.	Ruthenium Red	28-41	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	4-9
18550765-6	2008	Moreover, the cannabidiol-evoked CGRP release depended on extracellular calcium and was blocked by the nonselective TRP channel blocker, ruthenium red.	Ruthenium Red	137-150	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
18606820-9	2008	Compared with wild type, Ca(2+)-induced inhibition of respiration of htt(51Q) mitochondria was less sensitive to ruthenium red, indicating the involvement of extramitochondrial Ca(2+).	Ruthenium Red	113-126	huntingtin	Rattus norvegicus	69-72
18684885-9	2008	In the presence of the TRPV4-selective inhibitor ruthenium red, osmolality-induced ATP release was blocked by 73% (56.4+/-19.9 vs. 8.8+/-2.3 pmol/mg protein; n=6; P<0.03).	Ruthenium Red	49-62	transient receptor potential cation channel subfamily V member 4	Homo sapiens	23-28
18524860-4	2008	Inhibitors of ADPR cyclase (nicotinamide) or RyR (ruthenium red) reduced RBF responses to ET-1 by 44% (P < 0.04 for both) in Sprague-Dawley rats.	Ruthenium Red	50-63	ryanodine receptor 2	Rattus norvegicus	45-48
18524860-6	2008	Selective ETA receptor stimulation (ET-1+BQ788) produced decreases in RBF that were attenuated by 43 and 56% by nicotinamide or ruthenium red, respectively (P < 0.02 for both).	Ruthenium Red	128-141	endothelin receptor type A	Mus musculus	10-13
18524860-8	2008	ETB receptor stimulation by ET-1 + the ETA receptor antagonist BQ123 elicited responses that were attenuated by 59 and 60% by nicotinamide and ruthenium red, respectively (P < 0.01 for both).	Ruthenium Red	143-156	endothelin receptor type B	Mus musculus	0-3
18524860-8	2008	ETB receptor stimulation by ET-1 + the ETA receptor antagonist BQ123 elicited responses that were attenuated by 59 and 60% by nicotinamide and ruthenium red, respectively (P < 0.01 for both).	Ruthenium Red	143-156	endothelin receptor type A	Mus musculus	39-42
18362111-10	2008	CONCLUSIONS: Elevated pressure induces an influx of extracellular Ca(2+) in retinal microglia that precedes the activation of NFkappaB and the subsequent production and release of IL-6 and is at least partially dependent on the activation of TRPV1 and other ruthenium red-sensitive channels.	Ruthenium Red	258-271	interleukin 6	Rattus norvegicus	180-184
18395250-5	2008	Treatment with E(2) rapidly (<5 min) enhanced [Ca(2+)](i) and this increase was partially but significantly prevented when cells were pre-treated with ruthenium red and completely abolished in cells treated with siRNA specifically targeting TRPV6 protein expression.	Ruthenium Red	154-167	transient receptor potential cation channel subfamily V member 6	Homo sapiens	244-249
18514429-13	2008	MO-induced activity in Adelta-fibers is significantly reduced by Ruthenium Red (TRPA1 receptor antagonist).	Ruthenium Red	65-78	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	80-85
18181158-3	2008	The effect of regucalcin (10(-9) M) in increasing mitochondrial Ca(2+)-ATPase activity was completely inhibited in the presence of ruthenium red (10(-7) M) or lanthanum chloride (10(-7) M), both of which are inhibitors of mitochondrial uniporter activity.	Ruthenium Red	131-144	regucalcin	Rattus norvegicus	14-24
18425304-6	2008	(2) When ruthenium red (RR), an antagonist of TRPV4, was added to the hyposmotic perfusate (270 mOsm/L), the positive inotropic effect of hyposmia was restrained by 36% (P<0.01); and when RR was added to the hyperosmotic perfusate (390 mOsm/L), the inhibitory effect of hyperosmia on myocardial contractility was increased by 56.1% (P<0.01).	Ruthenium Red	9-22	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	46-51
18425304-6	2008	(2) When ruthenium red (RR), an antagonist of TRPV4, was added to the hyposmotic perfusate (270 mOsm/L), the positive inotropic effect of hyposmia was restrained by 36% (P<0.01); and when RR was added to the hyperosmotic perfusate (390 mOsm/L), the inhibitory effect of hyperosmia on myocardial contractility was increased by 56.1% (P<0.01).	Ruthenium Red	24-26	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	46-51
17872452-6	2007	Ruthenium red and the combination of charybdotoxin and apamin prevented the latter effect, suggesting that Trp channel activation increases Ca(2+) influx and prolongs the activation of Ca(2+)-dependent K(+) (K(Ca)) channels.	Ruthenium Red	0-13	casein kappa	Homo sapiens	208-213
17962608-9	2008	In TRPV4(+/+) lungs, the high pressure-induced permeability response was significantly attenuated by low calcium perfusate, the TRPV antagonist ruthenium red, the phospholipase A(2) inhibitor methyl arachidonyl fluorophosphonate, or the P450 epoxygenase inhibitor propargyloxyphenyl hexanoic acid.	Ruthenium Red	144-157	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	3-8
17962608-10	2008	Similarly, the high pressure-induced calcium transient in TRPV4(+/+) lungs was attenuated with ruthenium red or the epoxygenase inhibitor.	Ruthenium Red	95-108	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	58-63
17669489-4	2008	This calcium influx was also sensitive to Ni(2+) and to ruthenium red, a TRPV channel blocker, and mimicked by 4alpha-phorbol-12,13-didecanoate (4alpha-PDD), a TRPV4 channel agonist.	Ruthenium Red	56-69	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	160-165
17669489-5	2008	In patched PASMC, 5-HT and 4alpha-PDD-activated TRPV4-like ruthenium red sensitive currents with typical characteristics.	Ruthenium Red	59-72	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	48-53
18082143-5	2008	AITC induced cholecystokinin release was completely blocked by TRPA1 antagonist ruthenium red and depletion of extracellular calcium and reduced by 36% by nimodipine and nifedipine.	Ruthenium Red	80-93	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	63-68
18086308-5	2007	As reported previously, both human and rat TRPA1 are activated by AITC and inhibited by ruthenium red.	Ruthenium Red	88-101	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	43-48
17508360-5	2007	Capsaicin (CAP) (1-10 microM) increased nonselective cation channel whole cell currents (2.5-fold +/- 0.5-fold between -60 and 130 mV), resulting in calcium transients that were fully blocked by the TRPV1 antagonists capsazepine (CPZ) and ruthenium red, or removal of extracellular calcium.	Ruthenium Red	239-252	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-204
17827226-6	2007	Moreover, the reduced [Ca(2+)](SR) in HF myocytes could be nearly completely restored by the RyR2 channel blocker ruthenium red.	Ruthenium Red	114-127	ryanodine receptor 2	Canis lupus familiaris	93-97
17945425-9	2007	Icilin-induced activity was blocked by the TRPA1 antagonist Ruthenium Red.	Ruthenium Red	60-73	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	43-48
17970723-5	2007	TRPA1 antagonists camphor and gadolinium, and a general TRP blocker ruthenium red inhibited TRPA1 activation by acetaldehyde.	Ruthenium Red	68-81	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	92-97
18083933-6	2007	Yet common actions of the RyR-specific agents perchlorate, dantrolene Na, ryanodine, caffeine, adenosine 3",5"-cyclic diphosphate ribose (cADPr) and ruthenium red implicate RyR in signaling in all these cell types.	Ruthenium Red	149-162	ryanodine receptor 1	Homo sapiens	26-29
18083933-6	2007	Yet common actions of the RyR-specific agents perchlorate, dantrolene Na, ryanodine, caffeine, adenosine 3",5"-cyclic diphosphate ribose (cADPr) and ruthenium red implicate RyR in signaling in all these cell types.	Ruthenium Red	149-162	ryanodine receptor 1	Homo sapiens	173-176
17804410-6	2007	Activation of TRPV4 by a pharmacological activator induced SOX9-dependent reporter activity, and this effect was abolished by the addition of the TRPV antagonist ruthenium red or by using a small interfering RNA for TRPV4.	Ruthenium Red	162-175	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	14-19
17804410-6	2007	Activation of TRPV4 by a pharmacological activator induced SOX9-dependent reporter activity, and this effect was abolished by the addition of the TRPV antagonist ruthenium red or by using a small interfering RNA for TRPV4.	Ruthenium Red	162-175	SRY (sex determining region Y)-box 9	Mus musculus	59-63
17660328-5	2007	Pretreatment with inhibitors of TRPV4 (ruthenium red), arachidonic acid production (methanandamide), or P-450 epoxygenases (miconazole) prevented the increases in K(f).	Ruthenium Red	39-52	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	32-37
17652368-8	2007	Furthermore, RyR inhibition with ruthenium red attenuates ANG II and NE responses by 50 and 59%, respectively (P < or = 0.01).	Ruthenium Red	33-46	ryanodine receptor 2	Rattus norvegicus	13-16
17652368-8	2007	Furthermore, RyR inhibition with ruthenium red attenuates ANG II and NE responses by 50 and 59%, respectively (P < or = 0.01).	Ruthenium Red	33-46	angiotensinogen	Rattus norvegicus	58-64
17508023-5	2007	Heat-shock-induced MMP-1 expression was decreased by treatment of the TRPV1 inhibitors (capsazepine and ruthenium red) or knockdown of TRPV1 using RNA interference in HaCaT cells.	Ruthenium Red	104-117	matrix metallopeptidase 1	Homo sapiens	19-24
17508023-5	2007	Heat-shock-induced MMP-1 expression was decreased by treatment of the TRPV1 inhibitors (capsazepine and ruthenium red) or knockdown of TRPV1 using RNA interference in HaCaT cells.	Ruthenium Red	104-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
17151911-2	2007	Calmodulin antagonists calmidazolium and W-7 prevented the 7-ketocholesterol-induced mitochondrial damage, leading to caspase-3 activation and cell death, whereas Ca2+ channel blocker nicardipine, mitochondrial Ca2+ uptake inhibitor ruthenium red, and cell permeable Ca2+ chelator BAPTA-AM did not reduce it.	Ruthenium Red	233-246	calmodulin 1	Rattus norvegicus	0-10
17466935-5	2007	In HSR, the addition of 5 mM Mg(2+) or ruthenium red, conditions that close the ryanodine Ca(2+) channel, promoted a decrease in the ATPase activity, but the amount of heat released during ATP hydrolysis remained practically the same.	Ruthenium Red	39-52	HSR	Homo sapiens	3-6
17098283-4	2007	Neutralization of E1029 (conserved in TRPM6, TRPM7, TRPM4 and TRPM5) resulted in channels with increased conductance for Ba2+ and Zn2+, decreased ruthenium red sensitivity and larger pore diameter compared to wild-type TRPM6.	Ruthenium Red	146-159	transient receptor potential cation channel subfamily M member 6	Homo sapiens	38-43
17098283-4	2007	Neutralization of E1029 (conserved in TRPM6, TRPM7, TRPM4 and TRPM5) resulted in channels with increased conductance for Ba2+ and Zn2+, decreased ruthenium red sensitivity and larger pore diameter compared to wild-type TRPM6.	Ruthenium Red	146-159	transient receptor potential cation channel subfamily M member 7	Homo sapiens	45-50
17098283-4	2007	Neutralization of E1029 (conserved in TRPM6, TRPM7, TRPM4 and TRPM5) resulted in channels with increased conductance for Ba2+ and Zn2+, decreased ruthenium red sensitivity and larger pore diameter compared to wild-type TRPM6.	Ruthenium Red	146-159	transient receptor potential cation channel subfamily M member 4	Homo sapiens	52-57
17098283-4	2007	Neutralization of E1029 (conserved in TRPM6, TRPM7, TRPM4 and TRPM5) resulted in channels with increased conductance for Ba2+ and Zn2+, decreased ruthenium red sensitivity and larger pore diameter compared to wild-type TRPM6.	Ruthenium Red	146-159	transient receptor potential cation channel subfamily M member 5	Homo sapiens	62-67
17482476-5	2007	Extracellular application of the non-selective TRP channel blockers 2-APB, flufenamic acid, Gd3+, and ruthenium red, respectively, inhibited CCK induced inward currents.	Ruthenium Red	102-115	cholecystokinin	Mus musculus	141-144
17719182-7	2007	This effect was abolished by low micromolar concentration of the TRPV4 inhibitor Ruthenium Red.	Ruthenium Red	81-94	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	65-70
17396234-6	2007	Calcium-induced calcium release from mitochondria (mCICR) played a key role in mitochondrial dysfunction and cell apoptosis: (1) mCICR inhibitor, ruthenium red (RR), prevent MPT opening and Cyt.c release; and (2) RR attenuated resveratrol-induced HepG2 cell apoptotic death.	Ruthenium Red	146-159	corepressor interacting with RBPJ, 1	Mus musculus	51-56
17396234-6	2007	Calcium-induced calcium release from mitochondria (mCICR) played a key role in mitochondrial dysfunction and cell apoptosis: (1) mCICR inhibitor, ruthenium red (RR), prevent MPT opening and Cyt.c release; and (2) RR attenuated resveratrol-induced HepG2 cell apoptotic death.	Ruthenium Red	146-159	corepressor interacting with RBPJ, 1	Mus musculus	129-134
17396234-6	2007	Calcium-induced calcium release from mitochondria (mCICR) played a key role in mitochondrial dysfunction and cell apoptosis: (1) mCICR inhibitor, ruthenium red (RR), prevent MPT opening and Cyt.c release; and (2) RR attenuated resveratrol-induced HepG2 cell apoptotic death.	Ruthenium Red	146-159	cytochrome c, somatic	Homo sapiens	190-195
17396234-6	2007	Calcium-induced calcium release from mitochondria (mCICR) played a key role in mitochondrial dysfunction and cell apoptosis: (1) mCICR inhibitor, ruthenium red (RR), prevent MPT opening and Cyt.c release; and (2) RR attenuated resveratrol-induced HepG2 cell apoptotic death.	Ruthenium Red	161-163	corepressor interacting with RBPJ, 1	Mus musculus	51-56
17396234-6	2007	Calcium-induced calcium release from mitochondria (mCICR) played a key role in mitochondrial dysfunction and cell apoptosis: (1) mCICR inhibitor, ruthenium red (RR), prevent MPT opening and Cyt.c release; and (2) RR attenuated resveratrol-induced HepG2 cell apoptotic death.	Ruthenium Red	161-163	corepressor interacting with RBPJ, 1	Mus musculus	129-134
17396234-6	2007	Calcium-induced calcium release from mitochondria (mCICR) played a key role in mitochondrial dysfunction and cell apoptosis: (1) mCICR inhibitor, ruthenium red (RR), prevent MPT opening and Cyt.c release; and (2) RR attenuated resveratrol-induced HepG2 cell apoptotic death.	Ruthenium Red	161-163	cytochrome c, somatic	Homo sapiens	190-195
17645673-6	2007	The TRPV4 inhibitor, Ruthenium Red (RR) can effectively block such histamine release, indicating that TRPV4 was the key factor responding to laser irradiation.	Ruthenium Red	21-34	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	4-9
17645673-6	2007	The TRPV4 inhibitor, Ruthenium Red (RR) can effectively block such histamine release, indicating that TRPV4 was the key factor responding to laser irradiation.	Ruthenium Red	21-34	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	102-107
17645673-6	2007	The TRPV4 inhibitor, Ruthenium Red (RR) can effectively block such histamine release, indicating that TRPV4 was the key factor responding to laser irradiation.	Ruthenium Red	36-38	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	4-9
17645673-6	2007	The TRPV4 inhibitor, Ruthenium Red (RR) can effectively block such histamine release, indicating that TRPV4 was the key factor responding to laser irradiation.	Ruthenium Red	36-38	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	102-107
17332266-5	2007	EGTA and ruthenium red inhibited cell surface TRPV1 activity, but they did not prevent ER stress gene responses or cytotoxicity.	Ruthenium Red	9-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
17351641-4	2007	Using overexpression, knockdown (small interfering RNA) and mutagenesis experiments, we demonstrate that UCP2 and UCP3 are elementary for mitochondrial Ca(2+) sequestration in response to cell stimulation under physiological conditions - observations supported by isolated liver mitochondria of Ucp2(-/-) mice lacking ruthenium red-sensitive Ca(2+) uptake.	Ruthenium Red	318-331	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	105-109
17351641-4	2007	Using overexpression, knockdown (small interfering RNA) and mutagenesis experiments, we demonstrate that UCP2 and UCP3 are elementary for mitochondrial Ca(2+) sequestration in response to cell stimulation under physiological conditions - observations supported by isolated liver mitochondria of Ucp2(-/-) mice lacking ruthenium red-sensitive Ca(2+) uptake.	Ruthenium Red	318-331	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	114-118
17068482-4	2007	4Alpha-phorbol 12,13-didecanone, an activator of TRPV4, accelerated barrier recovery, whereas ruthenium red, a blocker of TRPV4, delayed barrier recovery.	Ruthenium Red	94-107	transient receptor potential cation channel subfamily V member 4	Homo sapiens	122-127
16879974-3	2006	Ruthenium red (3 mgkg(-1), s.c.), a non-competitive vanilloid receptor (V1, TRPV1)-antagonist also suppressed the capsaicin nociception by 38.6%.	Ruthenium Red	0-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	76-81
16564089-5	2006	Ba(2+) total patch currents were consistently blocked by addition of NiCl(2), Nifedipine (L-type voltage-gated calcium channel blocker) or Ruthenium Red (TRPV5-TRPV6 channel blocker); Nifedipine and Ruthenium Red exerted a synergic blocking effect on Ba(2+) total patch currents.	Ruthenium Red	139-152	transient receptor potential cation channel subfamily V member 5	Homo sapiens	154-159
16564089-5	2006	Ba(2+) total patch currents were consistently blocked by addition of NiCl(2), Nifedipine (L-type voltage-gated calcium channel blocker) or Ruthenium Red (TRPV5-TRPV6 channel blocker); Nifedipine and Ruthenium Red exerted a synergic blocking effect on Ba(2+) total patch currents.	Ruthenium Red	139-152	transient receptor potential cation channel subfamily V member 6	Homo sapiens	160-165
17008604-6	2006	The TRPV antagonist ruthenium red blocked the permeability response to the TRPV4 agonists, but not to thapsigargin.	Ruthenium Red	20-33	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	75-80
16571723-6	2006	Ca2+ entry was associated with a distinct nonselective cation current that was activated by 4alphaPDD and inhibited by ruthenium red, suggesting involvement of TRPV4.	Ruthenium Red	119-132	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	160-165
16786169-7	2006	The effect of regucalcin in increasing mitochondrial Ca2+-ATPase activity was not observed in the presence of ruthenium red (10(-7) M) or lanthanum chloride (10(-7) M), which is an inhibitor of Ca2+ uniporter.	Ruthenium Red	110-123	regucalcin	Rattus norvegicus	14-24
16439673-8	2006	The antidipsogenic effects of 4alpha-PDD were blocked by preinjection into the ventricle of TRPV4 antagonists such as ruthenium red or gadolinium.	Ruthenium Red	118-131	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	92-97
16751979-5	2006	Store-operated Ca2+ transient was inhibited by at least 50-70% by several inhibitors of the RyR, including ryanodine (10 microM), dantrolene (10 microM), and ruthenium red (10 microM).	Ruthenium Red	158-171	ryanodine receptor 1	Homo sapiens	92-95
16636964-7	2006	These responses to capsaicin were also greatly inhibited by ruthenium red (3 mg/kg, S. C.), a non-competitive capsaicin receptor (TRPV1) antagonist.	Ruthenium Red	60-73	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	110-128
16636964-7	2006	These responses to capsaicin were also greatly inhibited by ruthenium red (3 mg/kg, S. C.), a non-competitive capsaicin receptor (TRPV1) antagonist.	Ruthenium Red	60-73	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	130-135
16601147-9	2006	Further studies show that ruthenium red, an inhibitor of the mitochondrial Ca(2+) uniporter, blocks PUFA-induced Ca(2+) efflux from mitochondria, whereas inhibitors of the mitochondrial permeability transition pore cyclosporin A and bongkrekic acid have no effect.	Ruthenium Red	26-39	pumilio RNA binding family member 3	Homo sapiens	100-104
16519936-4	2006	Approximately 25% of the measured CaMKII autophosphorylation in DRG neurons in culture can be regulated by Ca(2+) flux from intracellular stores caused by manipulating [Ca(2+)](O), as shown by blocking refilling of store-operated Ca(2+)-channels with SK&F 96365, Ruthenium Red, and a partial block with Ni(2+).	Ruthenium Red	267-280	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	34-40
16450293-5	2006	While pretreatment with ruthenium red (3 mg/kg, s. c.), a non-specific transient receptor potential cation channel V1 (TRPV1) antagonist, also caused significant inhibition, the alpha (2)-adrenoceptor antagonist, yohimbine (2 mg/kg, s. c.), showed no significant effect.	Ruthenium Red	24-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	119-124
16407567-9	2006	The BNP effect was blocked by the ryanodine receptor modulators caffeine, ryanodine, and ruthenium red but not by the IP3 receptor antagonists heparin and xestospongin-C.	Ruthenium Red	89-102	natriuretic peptide B	Rattus norvegicus	4-7
16394515-8	2006	Pretreatment with ruthenium red (3 mg/kg, s.c.), a non-competitive TRPV1 antagonist alone caused significant inhibition of mustard oil-induced nociception but its co-administration with oleanolic acid produced neither antagonism nor potentiation of oleanolic acid antinociception.	Ruthenium Red	18-31	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	67-72
16467427-6	2006	CICR was reduced, and the remaining increase in [Ca2+]i was less effective in generating DSI, when the RyR antagonists, ryanodine or ruthenium red, were applied intracellularly, or the Ca2+ stores were depleted by the Ca2+-ATPase inhibitors, cyclopiazonic acid or thapsigargin.	Ruthenium Red	133-146	ryanodine receptor 1	Homo sapiens	103-106
16457780-3	2006	Furthermore, two different TRPV1 antagonists, capsazepine and ruthenium red prevented the contraction induced by both compounds.	Ruthenium Red	62-75	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-32
16585511-10	2006	Cells suppressed for hVDAC1 but expressing either native mVDAC1 or an E72Q mutant underwent apoptosis induced by various stimuli that can be inhibited by ruthenium red in the native cells but not in the mutated cells, suggesting that VDAC1 regulates apoptosis independent of the apoptosis-inducing pathway.	Ruthenium Red	154-167	voltage dependent anion channel 1	Homo sapiens	21-27
16585511-10	2006	Cells suppressed for hVDAC1 but expressing either native mVDAC1 or an E72Q mutant underwent apoptosis induced by various stimuli that can be inhibited by ruthenium red in the native cells but not in the mutated cells, suggesting that VDAC1 regulates apoptosis independent of the apoptosis-inducing pathway.	Ruthenium Red	154-167	voltage-dependent anion channel 1	Mus musculus	57-63
16585511-10	2006	Cells suppressed for hVDAC1 but expressing either native mVDAC1 or an E72Q mutant underwent apoptosis induced by various stimuli that can be inhibited by ruthenium red in the native cells but not in the mutated cells, suggesting that VDAC1 regulates apoptosis independent of the apoptosis-inducing pathway.	Ruthenium Red	154-167	voltage dependent anion channel 1	Homo sapiens	22-27
16537379-4	2006	Hypotonic reduction of AQP5 was blocked by ruthenium red, methanandamide, and miconazole, agents that inhibit the cation channel transient receptor potential vanilloid (TRPV) 4 present in lung epithelial cells.	Ruthenium Red	43-56	aquaporin 5	Mus musculus	23-27
16537379-6	2006	Similarly, addition of hypotonic PBS to mouse trachea in vivo decreased AQP5 within 1 h, an effect blocked by ruthenium red.	Ruthenium Red	110-123	aquaporin 5	Mus musculus	72-76
16537379-8	2006	Hypotonic reduction of AQP5 was observed only in the presence of TRPV4 and was blocked by ruthenium red.	Ruthenium Red	90-103	aquaporin 5	Mus musculus	23-27
16354767-7	2006	Sensitivity to zinc but insensitivity to ruthenium red were distinctive features of TRESK.	Ruthenium Red	41-54	potassium channel, subfamily K, member 18	Mus musculus	84-89
16176935-5	2005	Ruthenium red increased the binding of FKBP12.	Ruthenium Red	0-13	FKBP prolyl isomerase 1A	Homo sapiens	39-45
16133936-11	2005	The Ca2+ influx was blocked by ruthenium red, an inhibitor of TRPV1 channel.	Ruthenium Red	31-44	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	62-67
16164647-7	2005	Inhibition of the PTH-stimulated transepithelial Ca(2+) transport by the TRPV5-specific inhibitor ruthenium red reduced the PTH-stimulated expression of calbindin-D(28K) and NCX1 in rabbit CNT/CCD primary cultures.	Ruthenium Red	98-111	transient receptor potential cation channel subfamily V member 5	Oryctolagus cuniculus	73-78
16164647-7	2005	Inhibition of the PTH-stimulated transepithelial Ca(2+) transport by the TRPV5-specific inhibitor ruthenium red reduced the PTH-stimulated expression of calbindin-D(28K) and NCX1 in rabbit CNT/CCD primary cultures.	Ruthenium Red	98-111	sodium/calcium exchanger 1	Oryctolagus cuniculus	174-178
15937520-6	2005	Furthermore, NaHS-induced contraction was reduced by TRPV1 antagonism (ruthenium red, capsazepine and SB366791), and was abolished by pretreatment with the combination of tachykinin NK(1) (SR140333) and NK(2) (SR48968) receptor antagonists.	Ruthenium Red	71-84	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	53-58
15719027-0	2005	Ruthenium red-mediated suppression of Bcl-2 loss and Ca(2+) release initiated by photodamage to the endoplasmic reticulum: scavenging of reactive oxygen species.	Ruthenium Red	0-13	B cell leukemia/lymphoma 2	Mus musculus	38-43
15818409-4	2005	HK-I and ruthenium red (RuR) reduced the VDAC1 conductance but not that of E72Q-mVDAC1.	Ruthenium Red	9-22	voltage dependent anion channel 1	Homo sapiens	41-46
15924239-6	2005	Moreover, the TRPV5 inhibitor ruthenium red completely inhibited Ca2+ uptake in GFP-TRPV5-MDCK cells, whereas Ca2+ uptake in non-transfected cells was not inhibited.	Ruthenium Red	30-43	transient receptor potential cation channel subfamily V member 5	Canis lupus familiaris	14-19
15924239-6	2005	Moreover, the TRPV5 inhibitor ruthenium red completely inhibited Ca2+ uptake in GFP-TRPV5-MDCK cells, whereas Ca2+ uptake in non-transfected cells was not inhibited.	Ruthenium Red	30-43	transient receptor potential cation channel subfamily V member 5	Canis lupus familiaris	84-89
15653710-6	2005	In isolated pulmonary capsaicin-sensitive neurons, 2-APB concentration dependently evoked an inward current that was partially inhibited by capsazepine but almost completely abolished by ruthenium red, an effective blocker of all TRPV channels.	Ruthenium Red	187-200	arginyl aminopeptidase	Rattus norvegicus	53-56
15867381-7	2005	The uniporter inhibitors ruthenium red and Ru360 prevented caspase activation and bid cleavage, and almost entirely inhibited bortezomib-induced cell death, but had no effect on any other chemotherapeutic drug examined.	Ruthenium Red	25-38	BH3 interacting domain death agonist	Homo sapiens	82-85
15719027-5	2005	Ruthenium red (RR) devoid of Ru360 prevented Bcl-2 loss, release of Ca(2+) from the ER and the initiation of apoptosis.	Ruthenium Red	0-13	B cell leukemia/lymphoma 2	Mus musculus	45-50
15719027-5	2005	Ruthenium red (RR) devoid of Ru360 prevented Bcl-2 loss, release of Ca(2+) from the ER and the initiation of apoptosis.	Ruthenium Red	15-17	B cell leukemia/lymphoma 2	Mus musculus	45-50
15843607-6	2005	First, TRPA1 and the hair cell transducer share a unique set of pore properties not described for any other channel (block by gadolinium, amiloride, gentamicin, and ruthenium red, a ranging conductance of approximately 100 pS that is reduced to 54% by calcium, permeating calcium-induced potentiation followed by closure, and reopening by depolarization), supporting a direct role of TRPA1 as a pore-forming subunit of the hair cell transducer.	Ruthenium Red	165-178	transient receptor potential cation channel subfamily A member 1	Homo sapiens	7-12
15556833-4	2004	Pretreatment with the TRPV1 antagonist, capsazepine (10 microM) and ruthenium red (3 microM) significantly reduced the relaxation response to capsaicin by 78% (P<0.01) and 38% (P<0.05), respectively.	Ruthenium Red	68-81	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-27
15339793-7	2005	The mitochondrial Ca(2+) uniporter (MCU) played a key role in mitochondrial damage: 1) MCU inhibitors (La(3+), ruthenium red, Ru360) prevented swelling and cytochrome c release; and 2) ruthenium red attenuated Cd(2+) inhibition of PO(4)(3-)-induced swelling.	Ruthenium Red	111-124	mitochondrial calcium uniporter	Rattus norvegicus	36-39
15339793-7	2005	The mitochondrial Ca(2+) uniporter (MCU) played a key role in mitochondrial damage: 1) MCU inhibitors (La(3+), ruthenium red, Ru360) prevented swelling and cytochrome c release; and 2) ruthenium red attenuated Cd(2+) inhibition of PO(4)(3-)-induced swelling.	Ruthenium Red	111-124	mitochondrial calcium uniporter	Rattus norvegicus	87-90
15339793-7	2005	The mitochondrial Ca(2+) uniporter (MCU) played a key role in mitochondrial damage: 1) MCU inhibitors (La(3+), ruthenium red, Ru360) prevented swelling and cytochrome c release; and 2) ruthenium red attenuated Cd(2+) inhibition of PO(4)(3-)-induced swelling.	Ruthenium Red	185-198	mitochondrial calcium uniporter	Rattus norvegicus	36-39
15795312-5	2005	The RyR antagonists ruthenium red, ryanodine, tetracaine, and dantrolene greatly inhibited submaximal noradrenaline- and hypoxia-induced Ca2+ release and contraction in freshly isolated rat PASMCs, but did not affect ATP-induced Ca2+ release in cultured human PASMCs.	Ruthenium Red	20-33	ryanodine receptor 2	Rattus norvegicus	4-7
15795312-8	2005	Ruthenium red and tetracaine can further inhibit hypoxic increase in [Ca2+]i in RyR3-/- mouse PASMCs.	Ruthenium Red	0-13	ryanodine receptor 3	Mus musculus	80-84
15685214-4	2005	Piperine produced a clear agonist activity at the human TRPV1 receptor yielding rapidly activating whole-cell currents that were antagonised by the competitive TRPV1 antagonist capsazepine and the non-competitive TRPV1 blocker ruthenium red.	Ruthenium Red	227-240	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
15767306-5	2005	We have previously shown that the antagonists of the RyR, Ruthenium Red, high concentrations of ryanodine and 8-Br cADPR, diminish the [Ca(2+)](i) response to ET-1 in shark VSM.	Ruthenium Red	58-71	ryanodine receptor 2	Homo sapiens	53-56
15499375-5	2004	This was inhibited by cyclosporin A (5 microM) and Ruthenium Red (1 microg/ml), indicating the involvement of mitochondrial Ca2+ transport mechanisms.	Ruthenium Red	51-64	carbonic anhydrase 2	Homo sapiens	124-127
15075247-7	2004	The 4-alphaPDD-induced Ca(2+) response was inhibited by ruthenium red (1 microM), a known TRPV4 inhibitor, but not by capsazepine (1 microM), a TRPV1 antagonist, indicating that 4-alphaPDD-induced Ca(2+) response is mediated by TRPV4.	Ruthenium Red	56-69	transient receptor potential cation channel subfamily V member 4	Homo sapiens	90-95
15525465-6	2004	Pretreatment with ruthenium red (100 micromol/L), an antagonist of vanilloid receptor subtype 1 (VR1), blocked the effect of capsaicin on CBA.	Ruthenium Red	18-31	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	67-95
15525465-6	2004	Pretreatment with ruthenium red (100 micromol/L), an antagonist of vanilloid receptor subtype 1 (VR1), blocked the effect of capsaicin on CBA.	Ruthenium Red	18-31	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	97-100
15107298-2	2004	Cytosolic Ca2+ enters mitochondria through the ruthenium red-sensitive mCa2+ uniporter, but the mechanisms governing uniporter activity are unknown.	Ruthenium Red	47-60	carbonic anhydrase 2	Mus musculus	10-13
15107298-2	2004	Cytosolic Ca2+ enters mitochondria through the ruthenium red-sensitive mCa2+ uniporter, but the mechanisms governing uniporter activity are unknown.	Ruthenium Red	47-60	carbonic anhydrase 2	Mus musculus	71-75
15326217-8	2004	We employed three inhibitors of activation of the RyR, Ruthenium Red, 8-Br cADPR and high concentrations of ryanodine; these agents blocked the [Ca(2+)](i) response to ET(B)R agonist stimulation by a mean of 39%.	Ruthenium Red	55-68	endothelin receptor type B	Homo sapiens	168-174
15249421-5	2004	Capsazepine (vanilloid receptor-1 antagonist; 1-10 microm) and ruthenium red (inhibitor of vanilloid response; 1-30 microm) concentration-dependently inhibited the nicotine-induced vasodilation without affecting the vasodilator response to exogenous CGRP.	Ruthenium Red	63-76	calcitonin-related polypeptide alpha	Rattus norvegicus	250-254
15127133-6	2004	(2) By pretreatment with ruthenium red (RR, 100 micromol/L), an antagonist of vanilloid receptor subtype 1 (VR(1)), the above effects of CAP on carotid baroreflex were abolished.	Ruthenium Red	25-38	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-113
15246834-7	2004	Reducing mitochondrial Ca2+ uptake using ruthenium red (RuR) increased ionomycin-mediated NO production over ionomycin alone and indicates a critical role for mitochondria in nNOS regulation.	Ruthenium Red	41-54	nitric oxide synthase 1, neuronal	Mus musculus	175-179
15157689-1	2004	Capsaicin antagonists including ruthenium red, capsazepine and iodo-resiniferatoxin (I-RTX) have recently been shown to inhibit the activation by noxious heat of the capsaicin receptor (TRPV1) expressed in non-neuronal host cells, and natively, in cultured dorsal root ganglion cells.	Ruthenium Red	32-45	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	166-184
15157689-1	2004	Capsaicin antagonists including ruthenium red, capsazepine and iodo-resiniferatoxin (I-RTX) have recently been shown to inhibit the activation by noxious heat of the capsaicin receptor (TRPV1) expressed in non-neuronal host cells, and natively, in cultured dorsal root ganglion cells.	Ruthenium Red	32-45	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	186-191
15108363-7	2004	In addition, both ruthenium red and dantrolene had a strong inhibitory effect on IL-2-dependent proliferation of CTLL-2 T cells.	Ruthenium Red	18-31	interleukin 2	Mus musculus	81-85
15155534-5	2004	Moreover, WIN-2-evoked CGRP release was attenuated by the nonselective cation channel blocker ruthenium red but not by the vanilloid receptor type 1 (TRPV1) antagonist capsazepine, suggesting that, unlike certain endogenous and synthetic cannabinoids, WIN-2 is not a TRPV1 agonist but rather acts at an as yet unidentified cation channel.	Ruthenium Red	94-107	calcitonin related polypeptide alpha	Homo sapiens	23-27
15127133-6	2004	(2) By pretreatment with ruthenium red (RR, 100 micromol/L), an antagonist of vanilloid receptor subtype 1 (VR(1)), the above effects of CAP on carotid baroreflex were abolished.	Ruthenium Red	40-42	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-113
15125461-5	2004	The functional VR1 antagonists ruthenium red and capsazepine markedly aggravated HCl-induced gastric lesions in rats.	Ruthenium Red	31-44	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	15-18
15036951-4	2004	FK506-induced [Ca(2+)](i) increase was completely blocked by the RyR antagonist ruthenium red and ryanodine, but not the IP(3)R antagonist heparin.	Ruthenium Red	80-93	ryanodine receptor 1, skeletal muscle	Mus musculus	65-68
14592813-4	2004	In response to HGF, the TJ marker ZO-1 remained in morphologically complete rings and functional barriers to paracellular diffusion of ruthenium red were maintained in pseudostratified layers.	Ruthenium Red	135-148	hepatocyte growth factor	Canis lupus familiaris	15-18
14724196-7	2004	Extracellular application of the non-selective TRP channel blockers SKF 96365, flufenamic acid and ruthenium red caused reversible inhibition of mGluR1-activated EPSCs.	Ruthenium Red	99-112	glutamate metabotropic receptor 1	Rattus norvegicus	145-151
14625201-5	2004	Transcellular Ca(2+) transport across mpkDCT cells was completely inhibited by ruthenium red, an inhibitor of TRPV5 and TRPV6, but not by the voltage-operated Ca(2+) channel inhibitors felodipine and verapamil.	Ruthenium Red	79-92	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	110-115
14625201-5	2004	Transcellular Ca(2+) transport across mpkDCT cells was completely inhibited by ruthenium red, an inhibitor of TRPV5 and TRPV6, but not by the voltage-operated Ca(2+) channel inhibitors felodipine and verapamil.	Ruthenium Red	79-92	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	120-125
14625201-6	2004	With the use of patch-clamp analysis, the IC(50) of ruthenium red on Na(+) currents was between the values measured for TRPV5- and TRPV6-expressing HEK 293 cells, suggesting that TRPV5 and/or TRPV6 is possibly active in mpkDCT cells.	Ruthenium Red	52-65	transient receptor potential cation channel subfamily V member 5	Homo sapiens	120-125
14625201-6	2004	With the use of patch-clamp analysis, the IC(50) of ruthenium red on Na(+) currents was between the values measured for TRPV5- and TRPV6-expressing HEK 293 cells, suggesting that TRPV5 and/or TRPV6 is possibly active in mpkDCT cells.	Ruthenium Red	52-65	transient receptor potential cation channel subfamily V member 6	Homo sapiens	131-136
14625201-6	2004	With the use of patch-clamp analysis, the IC(50) of ruthenium red on Na(+) currents was between the values measured for TRPV5- and TRPV6-expressing HEK 293 cells, suggesting that TRPV5 and/or TRPV6 is possibly active in mpkDCT cells.	Ruthenium Red	52-65	transient receptor potential cation channel subfamily V member 5	Homo sapiens	179-184
14625201-6	2004	With the use of patch-clamp analysis, the IC(50) of ruthenium red on Na(+) currents was between the values measured for TRPV5- and TRPV6-expressing HEK 293 cells, suggesting that TRPV5 and/or TRPV6 is possibly active in mpkDCT cells.	Ruthenium Red	52-65	transient receptor potential cation channel subfamily V member 6	Homo sapiens	192-197
12401520-2	2003	By Northern blotting analyses and transient transfection assays, we herein show that transactivation of grp78 by OA-->HS is abolished by an intracellular calcium chelator, bis(aminophenoxy)ethane N,N"-tetraacetic acid (BAPTA), and an inhibitor of mitochondrial Ca(2+) uniporter, ruthenium red (RR), while unaffected by cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition pore (MTP).	Ruthenium Red	282-295	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	104-109
14519101-4	2003	Pretreatment of SR vesicles with the RyR1 antagonists Ruthenium Red and ryanodine as well as with lanthanum chloride blocked the GSH uptake.	Ruthenium Red	54-67	ryanodine receptor 1	Homo sapiens	37-41
14514756-4	2003	Moreover, eugenol caused elevation of [Ca(2+)](i), and this was completely abolished by both capsazepine and ruthenium red in VR1-expressing HEK 293 cells and TG neurons.	Ruthenium Red	109-122	transient receptor potential cation channel subfamily V member 1	Homo sapiens	126-129
14576148-7	2004	The TRPM6-induced channel displays strong outward rectification, has a 5-fold higher affinity for Mg2+ than for Ca2+, and is blocked in a voltage-dependent manner by ruthenium red.	Ruthenium Red	166-179	transient receptor potential cation channel subfamily M member 6	Homo sapiens	4-9
14576148-7	2004	The TRPM6-induced channel displays strong outward rectification, has a 5-fold higher affinity for Mg2+ than for Ca2+, and is blocked in a voltage-dependent manner by ruthenium red.	Ruthenium Red	166-179	mucin 7, secreted	Homo sapiens	98-101
14561013-4	2003	Indomethacin subcutaneously or ruthenium red intravenously, a nonspecific VR1 antagonist, was given 60 or 10 min, respectively, before exposure to capsaicin or acid, while L-NAME was given intravenously 3 hr before these treatments.	Ruthenium Red	31-44	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	74-77
12925006-7	2003	The TRPV1 antagonists capsazepine and ruthenium red substantially reduced the effects of pH 5.2 but not pH 6.1.	Ruthenium Red	38-51	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
12756567-6	2003	Both the Ca2+ response and the membrane current were abolished when BAPTA, ruthenium red or 8-NH(2)-cADPr were preinjected into the oocytes, while perfusion with ADPr did not elicit any [Ca2+](i) increase or ionic current.	Ruthenium Red	75-88	carbonic anhydrase 2	Homo sapiens	9-12
12684045-0	2003	Ruthenium red, inhibitor of mitochondrial Ca2+ uniporter, inhibits curcumin-induced apoptosis via the prevention of intracellular Ca2+ depletion and cytochrome c release.	Ruthenium Red	0-13	cytochrome c, somatic	Homo sapiens	149-161
12684045-6	2003	Cotreatment with ruthenium red markedly prevented the activation of caspase 3, cytochrome c release, and cell death, suggesting a role for intracellular Ca(2+) in this process.	Ruthenium Red	17-30	caspase 3	Homo sapiens	68-77
12684045-6	2003	Cotreatment with ruthenium red markedly prevented the activation of caspase 3, cytochrome c release, and cell death, suggesting a role for intracellular Ca(2+) in this process.	Ruthenium Red	17-30	cytochrome c, somatic	Homo sapiens	79-91
12604706-6	2003	Similarly, the TRPV1 blocker, ruthenium red (10 microM), inhibited the number of bradykinin-evoked action potentials by 75 +/- 10% (n = 4; P < 0.05).	Ruthenium Red	30-43	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	15-20
12606773-3	2003	We have reported previously that the cationic dye, ruthenium red (RR), inhibited homodimeric TASK-3 (kcnk9), whereas TASK-1 (kcnk3) homodimer and TASK-1/TASK-3 heterodimer were not affected by this compound.	Ruthenium Red	51-64	potassium two pore domain channel subfamily K member 9	Homo sapiens	101-106
12606773-3	2003	We have reported previously that the cationic dye, ruthenium red (RR), inhibited homodimeric TASK-3 (kcnk9), whereas TASK-1 (kcnk3) homodimer and TASK-1/TASK-3 heterodimer were not affected by this compound.	Ruthenium Red	66-68	potassium two pore domain channel subfamily K member 9	Homo sapiens	101-106
12401520-2	2003	By Northern blotting analyses and transient transfection assays, we herein show that transactivation of grp78 by OA-->HS is abolished by an intracellular calcium chelator, bis(aminophenoxy)ethane N,N"-tetraacetic acid (BAPTA), and an inhibitor of mitochondrial Ca(2+) uniporter, ruthenium red (RR), while unaffected by cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition pore (MTP).	Ruthenium Red	297-299	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	104-109
12111244-8	2002	Ruthenium red (RuR)-sensitive Ca(2+) efflux (mediated by the RyR2) was also reduced in the LVD group by approximately 50%, as was the remaining (RuR-insensitive) background Ca(2+) leak.	Ruthenium Red	0-13	ryanodine receptor 2	Oryctolagus cuniculus	61-65
12368236-4	2002	We show here that SB202190, an inhibitor of p38 mitogen-activated protein (MAP) kinase, strongly stimulates ruthenium red-sensitive mitochondrial Ca2+ uptake, both in intact and in permeabilized HeLa cells.	Ruthenium Red	108-121	mitogen-activated protein kinase 14	Homo sapiens	44-47
12466936-2	2002	GLP-1 produced [Ca(2+)](i) oscillations in the cells, both in media with and without Ca(2+), an effect inhibited by ruthenium red and mimicked by 8-Br-cAMPS.	Ruthenium Red	116-129	glucagon	Homo sapiens	0-5
12466936-7	2002	Our results indicate that GLP-1 initially generated a local [Ca(2+)](i) elevation at the peripheral cytoplasm, subsequently producing [Ca(2+)](i) oscillations that were inhibited by ruthenium red, involving ryanodine-sensitive and cAMP-activated CICR mechanisms.	Ruthenium Red	182-195	glucagon	Homo sapiens	26-31
12417255-6	2002	This pathway is sensitive to inhibitors of Ca(2+) uptake in the mitochondria (ruthenium red), Ca(2+) chelators (TMB-8, EGTA-AM), and antioxidants (PDTC, NAC, Mn-SOD).	Ruthenium Red	78-91	synuclein alpha	Homo sapiens	153-156
12417255-6	2002	This pathway is sensitive to inhibitors of Ca(2+) uptake in the mitochondria (ruthenium red), Ca(2+) chelators (TMB-8, EGTA-AM), and antioxidants (PDTC, NAC, Mn-SOD).	Ruthenium Red	78-91	superoxide dismutase 2	Homo sapiens	158-164
12167625-11	2002	Micrographs of lung endothelial cells from Cav-1-deficient mice demonstrate that the paracellular movement of Ruthenium Red is dramatically increased.	Ruthenium Red	110-123	caveolin 1, caveolae protein	Mus musculus	43-48
12121968-7	2002	Ruthenium red only reduced carbachol peak elevations of [Ca(2+)](i) in NT and PS1-WT cells and not in PS1-DeltaE9 cells.	Ruthenium Red	0-13	presenilin 1	Homo sapiens	78-81
12093812-2	2002	TRPV4 is characterized by both inward and outward rectification, voltage-dependent block by Ruthenium Red, a moderate selectivity for divalent versus monovalent cations, and an Eisenman IV permeability sequence.	Ruthenium Red	92-105	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
12151520-5	2002	In both cases these responses are observed at temperatures lower than those required to activate TRPV1 and can be inhibited reversibly by ruthenium red.	Ruthenium Red	138-151	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-102
11934703-7	2002	The conductance was tentatively classified as a RyR-gated Ca(2+) channel as it displayed characteristic metastable states and was sensitive to ruthenium red and a specific anti-RyR antibody, Ab(34).	Ruthenium Red	143-156	ryanodine receptor 2	Homo sapiens	48-51
11934703-7	2002	The conductance was tentatively classified as a RyR-gated Ca(2+) channel as it displayed characteristic metastable states and was sensitive to ruthenium red and a specific anti-RyR antibody, Ab(34).	Ruthenium Red	143-156	ryanodine receptor 2	Homo sapiens	177-180
11867697-6	2002	TaMDR1 was significantly induced by the exposure to lanthanum, gadolinium and ruthenium red, which are known as inhibitors of calcium channels.	Ruthenium Red	78-91	ABC transporter B family member 4	Triticum aestivum	0-6
11943493-2	2002	Heparin, a potent blocker of IP(3)R, prevented the activation of porcine oocytes using IP(3), but blockers of RyR (ruthenium red or procaine) prevented activation after stimulation by RyR and stimulation by IP(3)R using IP(3).	Ruthenium Red	115-128	ryanodine receptor 1	Sus scrofa	110-113
11943493-2	2002	Heparin, a potent blocker of IP(3)R, prevented the activation of porcine oocytes using IP(3), but blockers of RyR (ruthenium red or procaine) prevented activation after stimulation by RyR and stimulation by IP(3)R using IP(3).	Ruthenium Red	115-128	ryanodine receptor 1	Sus scrofa	184-187
12148843-11	2002	Furthermore, SICR was largely inhibited by pretreatment of cells with carbonyl cyanide m-cholorophenyl hydrazone (CCCP) or ruthenium red, inhibitors of mitochondrial Ca2+ uptake.	Ruthenium Red	123-136	carbonic anhydrase 2	Rattus norvegicus	166-169
12168728-6	2002	Activities of the coupled channels were decreased by 5 micromol/l ryanodine and inhibited by 10 micromol/l ruthenium red similarly as single RyR2 channels.	Ruthenium Red	107-120	ryanodine receptor 2	Homo sapiens	141-145
11891238-11	2002	There is a direct correlation between ADK activity and the level of methylesterified pectin in seed mucilage, as monitored by staining with ruthenium red, immunofluorescence labeling, or direct assay.	Ruthenium Red	140-153	adenosine kinase	Arabidopsis thaliana	38-41
11703449-5	2001	Capsazepine (10 microm) and Ruthenium Red (1 microm) used as capsaicin receptor/channel antagonists did not significantly inhibit the heat-induced release.	Ruthenium Red	28-41	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-79
11588099-11	2001	Ruthenium red and econazole appeared to be the most effective inhibitors of currents through ECaC1, with IC(50) values of 111 nM and 1.3 microM, respectively, whereas the selective SOC inhibitor, SKF96365, was nearly ineffective.	Ruthenium Red	0-13	transient receptor potential cation channel subfamily V member 5	Homo sapiens	93-98
11752091-7	2002	Pretreatment with VR1 receptor antagonists capsazepine or ruthenium red block both the calcium and sodium responses to agonists, and block agonist-induced cell death in a concentration-dependent manner.	Ruthenium Red	58-71	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-21
11744752-11	2001	Interestingly, ECaC2 has a 100-fold lower affinity for ruthenium red (IC(50) 9 +/- 1 microM) than ECaC1 (IC(50) 121 +/- 13 nM).	Ruthenium Red	55-68	transient receptor potential cation channel subfamily V member 6	Homo sapiens	15-20
11698030-11	2001	This increase is blocked by ruthenium red, suggesting that this effect is mediated through the vanilloid VR1 receptor.	Ruthenium Red	28-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	105-108
11429389-0	2001	Blockade by ruthenium red of tissue factor-initiated coagulation.	Ruthenium Red	12-25	coagulation factor III, tissue factor	Homo sapiens	29-42
11429389-1	2001	The ability of ruthenium red (RuR) to inhibit tissue factor (TF)-initiated blood coagulation was demonstrated at the protein and cellular levels as well as in human plasma.	Ruthenium Red	15-28	coagulation factor III, tissue factor	Homo sapiens	46-59
11429389-1	2001	The ability of ruthenium red (RuR) to inhibit tissue factor (TF)-initiated blood coagulation was demonstrated at the protein and cellular levels as well as in human plasma.	Ruthenium Red	15-28	coagulation factor III, tissue factor	Homo sapiens	61-63
11429389-1	2001	The ability of ruthenium red (RuR) to inhibit tissue factor (TF)-initiated blood coagulation was demonstrated at the protein and cellular levels as well as in human plasma.	Ruthenium Red	30-33	coagulation factor III, tissue factor	Homo sapiens	46-59
11429389-1	2001	The ability of ruthenium red (RuR) to inhibit tissue factor (TF)-initiated blood coagulation was demonstrated at the protein and cellular levels as well as in human plasma.	Ruthenium Red	30-33	coagulation factor III, tissue factor	Homo sapiens	61-63
11377377-7	2001	These parameters were restored to normal when the Ca2+ channel blocker ruthenium red was added.	Ruthenium Red	71-84	carbonic anhydrase 2	Homo sapiens	50-53
11027709-8	2000	Experiments with ruthenium red, which is a blocker of Ca(2+) fluxes in rice as well as maize (Zea mays), suggest that the induction of expression of Adh1 and Pdc1 by low oxygen stress is regulated by elevation of the cytosolic Ca(2+) level.	Ruthenium Red	17-30	pyruvate decarboxylase 1	Zea mays	158-162
11123235-5	2001	A high concentration of ryanodine (50 microM) and ruthenium red (40-80 microM) substantially inhibited the activity of RYR/Ca(2+) release channels.	Ruthenium Red	50-63	ryanodine receptor 2	Homo sapiens	119-122
11226681-11	2001	In vanilloid receptor 1 transfected cells, Ruthenium Red (10microM) blocked responses to both capsaicin and heat.	Ruthenium Red	43-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	3-23
11074600-4	2000	Ruthenium red (10(-6) M) or lanthunum chloride (10(-6) M), an inhibitor of mitochondrial Ca(2+) uptake, markedly inhibited regucalcin (100 nM)-increased mitochondrial Ca(2+)-ATPase activity and (45)Ca(2+) uptake.	Ruthenium Red	0-13	regucalcin	Rattus norvegicus	123-133
11041547-8	2000	Our result also suggests that the [Ca2+]i oscillation induced by glucose is involved in the release of Ca2+ from intracellular Ca2+ stores through the ryanodine receptor, which is blocked by ruthenium red, and/or through the inositol trisphosphate receptor that may be present in the membrane of insulin granules.	Ruthenium Red	191-204	carbonic anhydrase 2	Homo sapiens	35-38
11041547-8	2000	Our result also suggests that the [Ca2+]i oscillation induced by glucose is involved in the release of Ca2+ from intracellular Ca2+ stores through the ryanodine receptor, which is blocked by ruthenium red, and/or through the inositol trisphosphate receptor that may be present in the membrane of insulin granules.	Ruthenium Red	191-204	carbonic anhydrase 2	Homo sapiens	103-106
11041547-8	2000	Our result also suggests that the [Ca2+]i oscillation induced by glucose is involved in the release of Ca2+ from intracellular Ca2+ stores through the ryanodine receptor, which is blocked by ruthenium red, and/or through the inositol trisphosphate receptor that may be present in the membrane of insulin granules.	Ruthenium Red	191-204	carbonic anhydrase 2	Homo sapiens	103-106
11226139-8	2001	Capsazepine and ruthenium red were both more potent at blocking the capsaicin response of human VR1 than rat VR1.	Ruthenium Red	16-29	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-99
11226139-8	2001	Capsazepine and ruthenium red were both more potent at blocking the capsaicin response of human VR1 than rat VR1.	Ruthenium Red	16-29	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	109-112
11124973-7	2000	Ruthenium red (50 microm) and, to a lesser extent, heparin (3 mg/ml) antagonized IL-1beta-induced Ca(2+) release, and both compounds administered together completely abolished this response.	Ruthenium Red	0-13	interleukin 1 beta	Homo sapiens	81-89
11027709-8	2000	Experiments with ruthenium red, which is a blocker of Ca(2+) fluxes in rice as well as maize (Zea mays), suggest that the induction of expression of Adh1 and Pdc1 by low oxygen stress is regulated by elevation of the cytosolic Ca(2+) level.	Ruthenium Red	17-30	alcohol dehydrogenase 1	Zea mays	149-153
10864448-2	2000	The activity of the skeletal muscle (RyR1), cardiac muscle (RyR2), and brain (RyR3) ryanodine receptor isoforms have been shown to be highly regulated by physiological factors including pH, temperature, and ionic strength; endogenous compounds including Ca(2+), Mg(2+), and adenosine triphosphate (ATP); and pharmacological agents including caffeine, ruthenium red, and neomycin.	Ruthenium Red	351-364	ryanodine receptor 3	Homo sapiens	78-82
10952733-4	2000	LTD(GABA-A) was prevented when the cells were loaded with ruthenium red, a blocker of Ca2+-induced Ca2+ release (CICR) stores, whereas loading the cells with heparin, a blocker of IP3-induced Ca2+ release stores, had no effect.	Ruthenium Red	58-71	carbonic anhydrase 2	Rattus norvegicus	86-89
10968991-1	2000	We have compared the effects of the sarcoplasmic reticulum (SR) Ca(2+) release inhibitor, ruthenium red (RR), on single ryanodine receptor (RyR) channels in lipid bilayers, and on Ca(2+) sparks in permeabilized rat ventricular myocytes.	Ruthenium Red	90-103	ryanodine receptor 2	Rattus norvegicus	120-138
10968991-1	2000	We have compared the effects of the sarcoplasmic reticulum (SR) Ca(2+) release inhibitor, ruthenium red (RR), on single ryanodine receptor (RyR) channels in lipid bilayers, and on Ca(2+) sparks in permeabilized rat ventricular myocytes.	Ruthenium Red	90-103	ryanodine receptor 2	Rattus norvegicus	140-143
10968991-1	2000	We have compared the effects of the sarcoplasmic reticulum (SR) Ca(2+) release inhibitor, ruthenium red (RR), on single ryanodine receptor (RyR) channels in lipid bilayers, and on Ca(2+) sparks in permeabilized rat ventricular myocytes.	Ruthenium Red	105-107	ryanodine receptor 2	Rattus norvegicus	120-138
10968991-1	2000	We have compared the effects of the sarcoplasmic reticulum (SR) Ca(2+) release inhibitor, ruthenium red (RR), on single ryanodine receptor (RyR) channels in lipid bilayers, and on Ca(2+) sparks in permeabilized rat ventricular myocytes.	Ruthenium Red	105-107	ryanodine receptor 2	Rattus norvegicus	140-143
10952733-4	2000	LTD(GABA-A) was prevented when the cells were loaded with ruthenium red, a blocker of Ca2+-induced Ca2+ release (CICR) stores, whereas loading the cells with heparin, a blocker of IP3-induced Ca2+ release stores, had no effect.	Ruthenium Red	58-71	carbonic anhydrase 2	Rattus norvegicus	99-102
10952733-4	2000	LTD(GABA-A) was prevented when the cells were loaded with ruthenium red, a blocker of Ca2+-induced Ca2+ release (CICR) stores, whereas loading the cells with heparin, a blocker of IP3-induced Ca2+ release stores, had no effect.	Ruthenium Red	58-71	carbonic anhydrase 2	Rattus norvegicus	99-102
10882231-7	2000	An acidic region in IRAS-1 having an amino acid sequence nearly identical to that of ryanodine receptors led to the demonstration that ruthenium red, a dye that binds the acidic region in ryanodine receptors, also stained IRAS-1 as a 167-kD band on SDS gels and inhibited radioligand binding of native I1 sites in untransfected PC-12 cells (a source of authentic I1 binding sites).	Ruthenium Red	135-148	nischarin	Homo sapiens	20-24
10864900-7	2000	Capsazepine, isovelleral and ruthenium red all inhibited the capsaicin (100 nM)-induced Ca(2+) response in rVR1-HEK293 cells, with pK(B) values of 7.52+/-0.08, 6.92+/-0.11 and 8.09+/-0.12 respectively (n=6 each).	Ruthenium Red	29-42	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	107-111
10882231-7	2000	An acidic region in IRAS-1 having an amino acid sequence nearly identical to that of ryanodine receptors led to the demonstration that ruthenium red, a dye that binds the acidic region in ryanodine receptors, also stained IRAS-1 as a 167-kD band on SDS gels and inhibited radioligand binding of native I1 sites in untransfected PC-12 cells (a source of authentic I1 binding sites).	Ruthenium Red	135-148	nischarin	Homo sapiens	222-226
10617117-9	2000	Moreover, agents that suppress mitochondrial calcium uptake (ruthenium red) and membrane permeability transition (cyclosporin A) attenuated AP-1 activation by HNE, suggesting a contribution of mitochondrial alterations to AP-1 activation.	Ruthenium Red	61-74	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	140-144
10823662-0	2000	Stimulatory release of hepatic lipase activity from rat hepatocytes by ruthenium red.	Ruthenium Red	71-84	lipase C, hepatic type	Rattus norvegicus	23-37
10823662-1	2000	Ruthenium Red (RuR; ruthenium oxychloride ammoniated) stimulated the release of hepatic lipase (HTGL) activity from primary cultured rat hepatocytes into medium in a time- and dose-dependent manner.	Ruthenium Red	0-13	lipase C, hepatic type	Rattus norvegicus	80-94
10797571-4	2000	Ruthenium red (10(-5) M) or lanthanum chloride (10(-4) M), an inhibitor of mitochondrial Ca(2+) uptake, completely inhibited regucalcin (0.25 microM)-increased mitochondrial Ca(2+)-ATPase activity and (45)Ca(2+) uptake.	Ruthenium Red	0-13	regucalcin	Rattus norvegicus	125-135
11961588-4	2000	The excitatory response to intracarotid injection of capsaicin was significantly inhibited by pretreatment with the vanilloid receptor (capsaicin receptor) antagonist ruthenium red (200 mmol, 0.1 ml).	Ruthenium Red	167-180	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	136-154
10653978-6	2000	By exploiting the same transfection assay, we demonstrated that the up-regulation of the grp78 promoter by the protein phosphatase inhibitors is suppressed in the presence of the cytoplasmic calcium chelator bis(aminophenoxy)ethane N,N"-tetraacetic acid, the mitochondria calcium uniporter inhibitor ruthenium red as well as the antioxidants N-acetyl cysteine and pyrrolidinedithiocarbamate.	Ruthenium Red	300-313	heat shock protein family A (Hsp70) member 5	Homo sapiens	89-94
10807666-5	2000	Sanguinarine induced Ca(2+) release from the actively loaded SR vesicles was blocked by ruthenium red and dithiothreitol (DTT), consistent with the ryanodine receptor (RyR) as the site of sanguinarine action.	Ruthenium Red	88-101	ryanodine receptor 1, skeletal muscle	Mus musculus	168-171
10432322-10	1999	The DNFB-modified ryanodine-activated RyR channel showed fast transitions between open, closed and several sub-conductance states, and was completely closed by Ruthenium Red.	Ruthenium Red	160-173	ryanodine receptor 1	Homo sapiens	38-41
10531311-12	1999	We show that mtNOS-induced cytochrome c release is not mediated via the mitochondrial permeability transition pore because the release was aggravated by cyclosporin A and abolished by blockade of mitochondrial calcium uptake by ruthenium red.	Ruthenium Red	228-241	cytochrome c, somatic	Homo sapiens	27-39
10098900-8	1999	Ruthenium red (7.5 microM) prevented this effect with 10 microM of complex of Cd2+ with 1,3-bis(4-chlorbenzylidenamino)-guanidine and especially complex of Cd2+ with anabasine and Cd2+.	Ruthenium Red	0-13	Cd2 molecule	Rattus norvegicus	78-81
10462498-6	1999	Further analysis showed that ruthenium red and heparin differentially inhibit RANTES-, SDF-1alpha-, or MDC-induced calcium mobilization in IL-2-activated NK cells.	Ruthenium Red	29-42	C-C motif chemokine ligand 5	Rattus norvegicus	78-84
10028181-9	1999	Overexpression of PGL1-1 gene in a non-pectolytic strain resulted in halo formation on polygalacturonic acid-containing agar plates stained with ruthenium red.	Ruthenium Red	145-158	endo-polygalacturonase	Saccharomyces cerevisiae S288C	18-24
9989245-9	1999	MPP(+)-induced pore opening and cytochrome c release were blocked by CsA, the Ca2+ uniporter inhibitor ruthenium red, the hydrophobic disulfide reagent N-ethylmaleimide, butacaine, and the free radical scavenging enzymes catalase and superoxide dismutase.	Ruthenium Red	103-116	cytochrome c, somatic	Homo sapiens	32-44
10082424-2	1999	The presence of increased TNF-induced apoptosis causes a transient increase in epithelial permeability, but the epithelial barrier function recovers, as assessed by measuring the transepithelial electrical resistance, the paracellular flux of mannitol and by the electron microscopic evaluation of the penetration of the electron-dense dye ruthenium red across the tight junctions.	Ruthenium Red	340-353	tumor necrosis factor	Sus scrofa	26-29
10480313-4	1999	Propranolol, quin 2-AM, ruthenium red, and neomycin all inhibited LPL release more potently than the increase in activity.	Ruthenium Red	24-37	lipoprotein lipase	Rattus norvegicus	66-69
10417723-6	1999	Modification of eIF4E was mimicked by treatment with caffeine under aerobic conditions and blocked by treatment with ruthenium red under O2 deprivation, implicating Ca2+ as a second messenger in eIF4E modification.	Ruthenium Red	117-130	eukaryotic translation initiation factor 4E-1	Zea mays	16-21
10417723-6	1999	Modification of eIF4E was mimicked by treatment with caffeine under aerobic conditions and blocked by treatment with ruthenium red under O2 deprivation, implicating Ca2+ as a second messenger in eIF4E modification.	Ruthenium Red	117-130	eukaryotic translation initiation factor 4E-1	Zea mays	195-200
10390051-4	1999	Using ruthenium red staining, the lectin was shown to bind Ca2+ ions.	Ruthenium Red	6-19	lectin	Salmo salar	34-40
10222236-3	1999	In the present study, we achieved selective phosphorylation of the Ca2+-ATPase by endogenous CaM kinase in isolated rabbit cardiac SR vesicles utilizing a PLN monoclonal antibody (PLN AB) which inhibits PLN phosphorylation, and the RYR-CRC blocking drug, ruthenium red, which inhibits phosphorylation of RYR-CRC.	Ruthenium Red	255-268	cardiac phospholamban	Oryctolagus cuniculus	180-183
10222236-3	1999	In the present study, we achieved selective phosphorylation of the Ca2+-ATPase by endogenous CaM kinase in isolated rabbit cardiac SR vesicles utilizing a PLN monoclonal antibody (PLN AB) which inhibits PLN phosphorylation, and the RYR-CRC blocking drug, ruthenium red, which inhibits phosphorylation of RYR-CRC.	Ruthenium Red	255-268	cardiac phospholamban	Oryctolagus cuniculus	180-183
10098900-8	1999	Ruthenium red (7.5 microM) prevented this effect with 10 microM of complex of Cd2+ with 1,3-bis(4-chlorbenzylidenamino)-guanidine and especially complex of Cd2+ with anabasine and Cd2+.	Ruthenium Red	0-13	Cd2 molecule	Rattus norvegicus	156-159
10098900-8	1999	Ruthenium red (7.5 microM) prevented this effect with 10 microM of complex of Cd2+ with 1,3-bis(4-chlorbenzylidenamino)-guanidine and especially complex of Cd2+ with anabasine and Cd2+.	Ruthenium Red	0-13	Cd2 molecule	Rattus norvegicus	156-159
9819245-1	1998	The whole cell configuration of the patch-clamp technique was used to study the modulation gamma-aminobutyric acid (GABA)-mediated postsynaptic currents by ruthenium red in CA3 hippocampal neurons in slices obtained from postnatal (P) days P6-P10 old rats.	Ruthenium Red	156-169	carbonic anhydrase 3	Rattus norvegicus	173-176
9878167-6	1998	The intracellular calcium chelator BAPTA-AM and the inhibitor of mitochondrial calcium uptake ruthenium red protected neurons against Tat-induced apoptosis.	Ruthenium Red	94-107	tyrosine aminotransferase	Homo sapiens	134-137
9866676-1	1998	Increased binding of ruthenium red to pectin as the number of methyl esters attached to the pectin decreases was used as the basis for a gel diffusion assay for pectin methylesterase (PME, EC 3.1.1.11) activity.	Ruthenium Red	21-34	pectinesterase/pectinesterase inhibitor U1	Solanum lycopersicum	161-182
9866676-1	1998	Increased binding of ruthenium red to pectin as the number of methyl esters attached to the pectin decreases was used as the basis for a gel diffusion assay for pectin methylesterase (PME, EC 3.1.1.11) activity.	Ruthenium Red	21-34	pectinesterase/pectinesterase inhibitor U1	Solanum lycopersicum	184-187
9755842-0	1998	Ruthenium red inhibits cytosolic Ca2+ oscillations induced by vasopressin in primary cultured hepatocytes.	Ruthenium Red	0-13	arginine vasopressin	Rattus norvegicus	62-73
9754926-2	1998	This release was blocked by both 1 mM tetracaine and 30 microM ruthenium red which inhibit the ryanodine receptor or by pre-treatment with 10 mM caffeine which depletes the ryanodine receptor-containing Ca2+ stores.	Ruthenium Red	63-76	carbonic anhydrase 2	Mus musculus	203-206
9792230-9	1998	The behavior of histamine H2-receptor agonists was shared only by the Na+-blocker procaine, the intracellular Ca2+-antagonist ruthenium red and, at least in terms of efficacy, by the protein kinase C inhibitor, chelerithrine.	Ruthenium Red	126-139	histamine H2 receptor	Cavia porcellus	16-37
9688609-7	1998	Electron microscopy showed that PKC-delta overexpression results in a multilayered cell sheet, the tight junctions of which are almost uniformly permeable to ruthenium red.	Ruthenium Red	158-171	PRKCD	Sus scrofa	32-41
9688609-9	1998	As with LLC-PK1 cell sheets treated with 12-O-tetradecanoylphorbol-13-acetate, the reduced RT, increased D-mannitol flux, and tight junctional leakiness to ruthenium red that are seen with PKC-delta overexpression suggest the involvement of PKC-delta in regulation of tight junctional permeability.	Ruthenium Red	156-169	PRKCD	Sus scrofa	189-198
9611131-3	1998	cADPR (10 nM-10 microM) induced a dose-dependent increase in [Ca2+]i, which was blocked by the cADPR receptor antagonist 8-amino-cADPR (20 microM) and by the RyR blockers ruthenium red (10 microM) and ryanodine (10 microM), but not by the inositol 1,4,5-trisphosphate receptor blocker heparin (0.5 mg/ml).	Ruthenium Red	171-184	ryanodine receptor 1, skeletal muscle	Mus musculus	158-161
9618556-5	1998	We find that SNAP-25 cleavage also perturbs PKA-dependent modulation of secretion; facilitation of ruthenium red-evoked neurotransmitter release by the adenylyl cyclase activator forskolin is blocked completely after Botulinum toxin A action.	Ruthenium Red	99-112	synaptosome associated protein 25	Homo sapiens	13-20
9494083-6	1998	In contrast, Ruthenium Red markedly enhanced the thapsigargin-stimulated Ca2+o-induced increase in [Ca2+]c in both the presence and absence of increased cAMP (induced by forskolin and dibutyryl cAMP).	Ruthenium Red	13-26	carbonic anhydrase 2	Rattus norvegicus	73-76
9572473-4	1998	HSR actively exchanged Ca2+ with the medium through a partially open ryanodine-binding channel (RyR), as evidenced by the rapid attainment of a steady-state gradient between HSR and medium, which was promptly increased by the closure of the channel with ruthenium red (RR) or collapsed by its opening with caffeine.	Ruthenium Red	254-267	ryanodine receptor 1	Homo sapiens	96-99
9572473-4	1998	HSR actively exchanged Ca2+ with the medium through a partially open ryanodine-binding channel (RyR), as evidenced by the rapid attainment of a steady-state gradient between HSR and medium, which was promptly increased by the closure of the channel with ruthenium red (RR) or collapsed by its opening with caffeine.	Ruthenium Red	269-271	ryanodine receptor 1	Homo sapiens	96-99
9494083-6	1998	In contrast, Ruthenium Red markedly enhanced the thapsigargin-stimulated Ca2+o-induced increase in [Ca2+]c in both the presence and absence of increased cAMP (induced by forskolin and dibutyryl cAMP).	Ruthenium Red	13-26	carbonic anhydrase 2	Rattus norvegicus	100-103
9606011-10	1998	After C10 exposure, both tight junctions with normal morphology and those with dilatations showed an increased permeability to ruthenium red, indicating that C10 enhanced the paracellular transport of molecules with a MW < 1,000.	Ruthenium Red	127-140	homeobox C10	Homo sapiens	158-161
9325322-8	1997	Strong 45Ca2+ and ruthenium red binding domains were localized in the N-terminal region of the InsP3R as follows: two Ca2+-binding domains were located within the InsP3-binding domain, and three Ca2+ binding stretches were localized in a 500-amino acid region just downstream of the InsP3-binding domain.	Ruthenium Red	18-31	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	95-101
9305876-10	1997	The cloned RyR3 was activated by ATP, caffeine, and perchlorate, inhibited by Mg2+ and ruthenium red, and modified by ryanodine.	Ruthenium Red	87-100	ryanodine receptor 3	Homo sapiens	11-15
9326287-9	1997	These actions of caffeine were saturable, modulated by ryanodine, and inhibited by the RYR antagonists ruthenium red and procaine.	Ruthenium Red	103-116	ryanodine receptor 1	Homo sapiens	87-90
9142939-6	1997	In contrast, ruthenium red, a RyR antagonist, completely abolished ACh-induced [Ca2+]i oscillations.	Ruthenium Red	13-26	ryanodine receptor 1, skeletal muscle	Mus musculus	30-33
9103504-6	1997	In the isolated right and left guinea pig atria, GLNVA (0.01-10 microM) produced concentration-dependent positive inotropic and chronotropic effects, but these effects were inhibited by pretreatments with ruthenium red (1.0 microM), capsazepine (10 microM), human calcitonin-gene-related peptide (CGRP(8-37)) (1.0 microM) and sensory neuron denervation, respectively.	Ruthenium Red	205-218	calcitonin related polypeptide alpha	Homo sapiens	297-301
9065852-10	1997	The induction of LTD, but not long-term potentiation (LTP), was also strongly inhibited by ruthenium red, an agent known to block the ryanodine receptors located on intracellular Ca2+ stores.	Ruthenium Red	91-104	carbonic anhydrase 2	Rattus norvegicus	179-182
8891596-5	1996	However, the cardioprotection provided by CGRP- or capsaicin-induced preconditioning was abolished by CGRP-(8-37) and ruthenium red, respectively.	Ruthenium Red	118-131	calcitonin-related polypeptide alpha	Rattus norvegicus	42-46
8961948-13	1996	The CCl4-induced calcium release was blocked by ruthenium red, a specific inhibitor of the ryanodine receptor; ruthenium red did not block CCl4 metabolism to CCl3.	Ruthenium Red	48-61	C-C motif chemokine ligand 4	Rattus norvegicus	4-8
8985597-11	1996	In the presence of ruthenium red (a non-specific blocker of the mitochondrial Ca(2+)-uniporter) in the pipette, GnRH does not induce rhythmic [Ca2+]i oscillations.	Ruthenium Red	19-32	gonadotropin releasing hormone 1	Rattus norvegicus	112-116
9032683-9	1997	Blockade of Ca2+ release from internal stores by perifusion with ryanodine or dantrolene, or direct diffusion of Ruthenium Red into cells suppressed DAP amplitudes by approximately 50% and shortened their durations.	Ruthenium Red	113-126	death-associated protein	Rattus norvegicus	149-152
8994600-3	1997	Single FKBP12-depleted RyR channels, incorporated into planar lipid bilayers, were modulated by Ca2+, ATP, ryanodine, and ruthenium red in the cis chamber and opened frequently to the normal maximum conductance of approximately 230 pS and to substate levels of approximately 0.25, approximately 0.5, and approximately 0.75 of the maximum conductance.	Ruthenium Red	122-135	peptidyl-prolyl cis-trans isomerase FKBP1A	Oryctolagus cuniculus	7-13
8887781-18	1996	The 5 Hz LFS-induced LTP in the presence of ryanodine was blocked by Ruthenium Red, an agent known to block RyR channel opening, and also by thapsigargin, an agent known to block-ATP-dependent Ca2+ uptake into endoplasmic reticulum.	Ruthenium Red	69-82	ryanodine receptor 2	Rattus norvegicus	108-111
8864557-18	1996	The ETX-induced CGRP release is dependent on extracellular Ca2+ influx and involves a ruthenium red-sensitive mechanism.	Ruthenium Red	86-99	calcitonin-related polypeptide alpha	Rattus norvegicus	16-20
8726469-2	1996	The responses to the cis side Ca2+, ruthenium red and ryanodine confirmed that both were the currents through one Ca2+ release channel.	Ruthenium Red	36-49	ryanodine receptor 2	Oryctolagus cuniculus	114-134
8780250-2	1996	The objective of the present study was to further characterize this putative RyR by use of the two well-known cell-impermeant RyR modulators, ruthenium red and adenosine 3",5"-cyclic diphosphate ribose (cADPr).	Ruthenium Red	142-155	ryanodine receptor 2	Rattus norvegicus	77-80
8780250-2	1996	The objective of the present study was to further characterize this putative RyR by use of the two well-known cell-impermeant RyR modulators, ruthenium red and adenosine 3",5"-cyclic diphosphate ribose (cADPr).	Ruthenium Red	142-155	ryanodine receptor 2	Rattus norvegicus	126-129
8780250-8	1996	Finally, the cytosolic Ca2+ response to caffeine (5 x 10(-4) M), another RyR modulator, was also strongly attenuated by pretreatment with 5 x 10(-9) M ruthenium red.	Ruthenium Red	151-164	ryanodine receptor 2	Rattus norvegicus	73-76
8864557-8	1996	Pretreatment of MAB with capsaicin or ruthenium red inhibited ETX-induced CGRP release by 90% and 71%, respectively.	Ruthenium Red	38-51	calcitonin-related polypeptide alpha	Rattus norvegicus	74-78
9019533-15	1996	Slow tail currents and [Ca2+]i decay following 0.2 - 2 s depolarizations were much prolonged by mitochondrial inhibition with carbonyl cyanide m-chlorophenylhydrazone (CCCP) or Ruthenium Red, which abolished the initial rapid decay and plateau of [Ca2+]i.	Ruthenium Red	177-190	carbonic anhydrase 2	Rattus norvegicus	24-27
9019533-15	1996	Slow tail currents and [Ca2+]i decay following 0.2 - 2 s depolarizations were much prolonged by mitochondrial inhibition with carbonyl cyanide m-chlorophenylhydrazone (CCCP) or Ruthenium Red, which abolished the initial rapid decay and plateau of [Ca2+]i.	Ruthenium Red	177-190	carbonic anhydrase 2	Rattus norvegicus	248-251
8758688-7	1996	Pretreated MAB with capsaicin or ruthenium red inhibited ETX-induced release of CGRP by 90% and 65% respectively.	Ruthenium Red	33-46	calcitonin-related polypeptide alpha	Rattus norvegicus	80-84
8758688-10	1996	The release of CGRP is dependent on extra-cellular Ca2+ and Ca2+-induced Ca2+ release from the intracellular Ca2+ store which is sensitive to ruthenium red.	Ruthenium Red	142-155	calcitonin-related polypeptide alpha	Rattus norvegicus	15-19
8699918-0	1996	Capsaicin-induced biphasic oxygen uptake in rat muscle: antagonism by capsazepine and ruthenium red provides further evidence for peripheral vanilloid receptor subtypes (VN1/VN2).	Ruthenium Red	86-99	vomeronasal 1 receptor 102	Rattus norvegicus	174-177
8699918-6	1996	Low concentrations of the capsaicin antagonist ruthenium red selectively blocked the putative VN2 receptor-mediated effects produced by high concentrations of capsaicin.	Ruthenium Red	47-60	vomeronasal 1 receptor 102	Rattus norvegicus	94-97
8966752-0	1996	[Changes in the effect of Cd2+ on the respiration of isolated rat liver mitochondria after their preincubation with Ca2+, Sr2+, Ba2+, Mn2+ and ruthenium red].	Ruthenium Red	143-156	Cd2 molecule	Rattus norvegicus	26-29
8966752-2	1996	Change of Cd2+ action over a wide range of its concentrations on respiration of rat liver mitochondria in states 4, 3 and in the presence of 2, 4-dinitrophenol (DNP) after mitochondrial preincubation with Ca2+, Sr2+, Ba2+, Mn2+ or ruthenium Red (RR) was studied in vitro.	Ruthenium Red	231-244	Cd2 molecule	Rattus norvegicus	10-13
8966752-2	1996	Change of Cd2+ action over a wide range of its concentrations on respiration of rat liver mitochondria in states 4, 3 and in the presence of 2, 4-dinitrophenol (DNP) after mitochondrial preincubation with Ca2+, Sr2+, Ba2+, Mn2+ or ruthenium Red (RR) was studied in vitro.	Ruthenium Red	246-248	Cd2 molecule	Rattus norvegicus	10-13
7545124-7	1995	The inhibitory effect of ruthenium red and capsaicin on the bradykinin response may be due to inhibition of thromboxane A2 release or arachidonic mobilisation.	Ruthenium Red	25-38	kininogen 1	Homo sapiens	60-70
8762448-4	1995	Ruthenium red, an inhibitor of Ca(2+)-induced Ca2+ release from intracellular Ca2+ pools, significantly inhibited the release of CGRP.	Ruthenium Red	0-13	calcitonin-related polypeptide alpha	Rattus norvegicus	129-133
8762448-6	1995	The above results suggest that the observed release of CGRP in MAB was mediated by capsaicin-sensitive sensory nerve endings, as a result of Ca(2+)-induced Ca2+ release from the intracellular Ca2+ store which is sensitive to ruthenium red.	Ruthenium Red	225-238	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
7657829-5	1995	The binding was displaced by ryanodine itself, the CaR agonist Ni2+ and the RyR antagonist ruthenium red.	Ruthenium Red	91-104	ryanodine receptor 2	Rattus norvegicus	76-79
7772032-7	1995	Spermine displaced Tb3+ and Ruthenium Red from the ATPase, consistent with binding in the stalk region of the ATPase.	Ruthenium Red	28-41	dynein axonemal heavy chain 8	Homo sapiens	51-57
7545124-1	1995	We previously demonstrated that the bradykinin-induced contraction of human isolated small bronchi is inhibited by indomethacin, capsaicin (N-methyl-N-6-nonenamide) and ruthenium red but not by tachykinin receptor antagonists.	Ruthenium Red	169-182	kininogen 1	Homo sapiens	36-46
8788122-3	1995	Ruthenium Red inhibits the T-cell proliferative response (with an IC50 approximately 100 nM) to a wide variety of agents, including viral antigens from herpes simplex virus, tetanus toxoid, alloantigens and IL-2.	Ruthenium Red	0-13	interleukin 2	Mus musculus	207-211
12506420-6	1995	In contrast, ruthenium red (1 x 10(-5) M), capsaicin antagonist, almost completely prevented acid (pH 4.0)-stimulated CGRP release.	Ruthenium Red	13-26	calcitonin-related polypeptide alpha	Rattus norvegicus	118-122
7544580-3	1995	The activatory effect of calmodulin was reversed by 10 microM ruthenium red.	Ruthenium Red	62-75	calmodulin	Oryctolagus cuniculus	25-35
7473240-8	1995	Intracellular application of Ruthenium Red through the patch pipette blocked caffeine-induced Ca2+ transients in Purkinje neurones.	Ruthenium Red	29-42	carbonic anhydrase 2	Rattus norvegicus	94-97
7516710-3	1994	Ca2+ influx was slightly inhibited by 5 microM Ruthenium red and completely blocked by La3+ with a half-maximal inhibition attained at 50 microM.	Ruthenium Red	47-60	carbonic anhydrase 2	Homo sapiens	0-3
7543315-11	1995	Ruthenium red inhibited both MBP- and glucose-stimulated insulin release as well as MBP-induced glucagon release.	Ruthenium Red	0-13	myelin basic protein	Rattus norvegicus	29-32
7543315-11	1995	Ruthenium red inhibited both MBP- and glucose-stimulated insulin release as well as MBP-induced glucagon release.	Ruthenium Red	0-13	myelin basic protein	Rattus norvegicus	84-87
7866021-7	1994	Ruthenium red blocked the anoxic [Ca]i elevation and also the induction of adh1 (encoding alcohol dehydrogenase) and sh1 (encoding sucrose synthase) mRNA.	Ruthenium Red	0-13	alcohol dehydrogenase 1	Zea mays	75-79
7866021-7	1994	Ruthenium red blocked the anoxic [Ca]i elevation and also the induction of adh1 (encoding alcohol dehydrogenase) and sh1 (encoding sucrose synthase) mRNA.	Ruthenium Red	0-13	uncharacterized protein LOC100285036	Zea mays	90-111
7866021-7	1994	Ruthenium red blocked the anoxic [Ca]i elevation and also the induction of adh1 (encoding alcohol dehydrogenase) and sh1 (encoding sucrose synthase) mRNA.	Ruthenium Red	0-13	sucrose synthase 1	Zea mays	117-120
7522409-4	1994	Cooling release of Ca2+ was also observed in the presence of ryanodine or ruthenium red to block the ryanodine-sensitive Ca2+ efflux pathway.	Ruthenium Red	74-87	carbonic anhydrase 2	Canis lupus familiaris	19-22
7522409-4	1994	Cooling release of Ca2+ was also observed in the presence of ryanodine or ruthenium red to block the ryanodine-sensitive Ca2+ efflux pathway.	Ruthenium Red	74-87	carbonic anhydrase 2	Canis lupus familiaris	121-124
7536932-6	1995	Inhibition of [Ca2+]i changes by ruthenium red and ryanodine indicates that ryanodine receptor/Ca2+ release channels are involved in FKBP12-induced Ca2+ signaling.	Ruthenium Red	33-46	FKBP prolyl isomerase 1A	Homo sapiens	133-139
7540095-13	1995	[3H]-ryanodine binding to HSR was suppressed by ruthenium red, Mg2+ and procaine, but was not affected by DBHC up to 100 microM.	Ruthenium Red	48-61	HSR	Homo sapiens	26-29
7521330-0	1994	Identification of calmodulin-, Ca(2+)-, and ruthenium red-binding domains in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum.	Ruthenium Red	44-57	ryanodine receptor 2	Oryctolagus cuniculus	81-171
7521330-2	1994	The fusion proteins, which covered about 90% of the linear sequence of the ryanodine receptor, were used to identify calmodulin- (CaM), Ca(2+)-, and ruthenium red-binding regions in the ryanodine receptor through the use of 125I-CaM, 45Ca2+, and ruthenium red overlay procedures.	Ruthenium Red	149-162	LOC100009439	Oryctolagus cuniculus	75-93
7521330-2	1994	The fusion proteins, which covered about 90% of the linear sequence of the ryanodine receptor, were used to identify calmodulin- (CaM), Ca(2+)-, and ruthenium red-binding regions in the ryanodine receptor through the use of 125I-CaM, 45Ca2+, and ruthenium red overlay procedures.	Ruthenium Red	149-162	LOC100009439	Oryctolagus cuniculus	186-204
7521330-2	1994	The fusion proteins, which covered about 90% of the linear sequence of the ryanodine receptor, were used to identify calmodulin- (CaM), Ca(2+)-, and ruthenium red-binding regions in the ryanodine receptor through the use of 125I-CaM, 45Ca2+, and ruthenium red overlay procedures.	Ruthenium Red	246-259	LOC100009439	Oryctolagus cuniculus	75-93
7521330-2	1994	The fusion proteins, which covered about 90% of the linear sequence of the ryanodine receptor, were used to identify calmodulin- (CaM), Ca(2+)-, and ruthenium red-binding regions in the ryanodine receptor through the use of 125I-CaM, 45Ca2+, and ruthenium red overlay procedures.	Ruthenium Red	246-259	calmodulin	Oryctolagus cuniculus	117-127
7521330-2	1994	The fusion proteins, which covered about 90% of the linear sequence of the ryanodine receptor, were used to identify calmodulin- (CaM), Ca(2+)-, and ruthenium red-binding regions in the ryanodine receptor through the use of 125I-CaM, 45Ca2+, and ruthenium red overlay procedures.	Ruthenium Red	246-259	LOC100009439	Oryctolagus cuniculus	186-204
7521330-7	1994	Strong 45Ca(2+)- and ruthenium red-binding sites domains were localized in the NH2- and COOH-terminal regions of the ryanodine receptor and in regions 6, 12, and 13.	Ruthenium Red	21-34	LOC100009439	Oryctolagus cuniculus	117-135
7521330-11	1994	267, 23318-23326), show that strong CaM-, Ca(2+)-, and ruthenium red-binding domains are colocalized in the skeletal muscle ryanodine receptor.	Ruthenium Red	55-68	ryanodine receptor 1	Oryctolagus cuniculus	108-142
7955356-5	1994	This RTX-induced increase in CGRP immunoreactivity was completely blocked by Ruthenium red (RR).	Ruthenium Red	77-90	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	29-33
7955356-5	1994	This RTX-induced increase in CGRP immunoreactivity was completely blocked by Ruthenium red (RR).	Ruthenium Red	92-94	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	29-33
7518090-4	1994	Ruthenium red (RR), an inhibitor of organellar Ca fluxes, repressed the anoxic activation of the alcohol dehydrogenase1 and shrunken1 genes as measured by their transcript levels as well as ADH activity.	Ruthenium Red	0-13	alcohol dehydrogenase 1	Zea mays	97-119
7518235-7	1994	In the presence of ruthenium red, 3,5(Me)2NAPQI-induced Ca2+ release was accompanied by irreversible pyridine nucleotide oxidation and followed by the release of nucleotides into the extramitochondrial medium, events which were prevented on preincubation with CSA.	Ruthenium Red	19-32	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	260-263
7518235-9	1994	In addition to their inhibitory effect on the 3,5(Me)2NAPQI-induced Ca2+ release, CSA, ADP or MIBG also decreased the rate of the basal, ruthenium red-induced mitochondrial Ca2+ release by 45-70%.	Ruthenium Red	137-150	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	82-85
7518235-10	1994	It is proposed that the basal, ruthenium red-induced and the prooxidant-induced mitochondrial Ca2+ release occur through a common component that is sensitive to inhibition by CSA, ADP and MIBG and that is involved in mitochondrial pore formation.	Ruthenium Red	31-44	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	175-178
7518090-4	1994	Ruthenium red (RR), an inhibitor of organellar Ca fluxes, repressed the anoxic activation of the alcohol dehydrogenase1 and shrunken1 genes as measured by their transcript levels as well as ADH activity.	Ruthenium Red	0-13	sucrose synthase 1	Zea mays	124-133
7518090-4	1994	Ruthenium red (RR), an inhibitor of organellar Ca fluxes, repressed the anoxic activation of the alcohol dehydrogenase1 and shrunken1 genes as measured by their transcript levels as well as ADH activity.	Ruthenium Red	15-17	alcohol dehydrogenase 1	Zea mays	97-119
7518090-4	1994	Ruthenium red (RR), an inhibitor of organellar Ca fluxes, repressed the anoxic activation of the alcohol dehydrogenase1 and shrunken1 genes as measured by their transcript levels as well as ADH activity.	Ruthenium Red	15-17	sucrose synthase 1	Zea mays	124-133
8153052-6	1993	This reaction was shown to be mediated by tachykinins acting on the NK1 receptor through a mechanism which appeared to be resistant to capsazepine and ruthenium red and independent of cyclooxygenase products.	Ruthenium Red	151-164	tachykinin receptor 1	Rattus norvegicus	68-80
7509245-6	1994	Capsaicin 10(-5) M, which selectively depletes C fibers from airway mediators through the ruthenium red pathway, and ruthenium red 10(-5) M significantly inhibited the concentration-response curves to Bk.	Ruthenium Red	90-103	kininogen 1	Homo sapiens	201-203
7509245-6	1994	Capsaicin 10(-5) M, which selectively depletes C fibers from airway mediators through the ruthenium red pathway, and ruthenium red 10(-5) M significantly inhibited the concentration-response curves to Bk.	Ruthenium Red	117-130	kininogen 1	Homo sapiens	201-203
8136357-4	1994	Fragments of calnexin have been prepared as glutathione S-transferase fusion proteins and analyzed for their abilities to bind 45Ca2+ and ruthenium red.	Ruthenium Red	138-151	calnexin	Homo sapiens	13-21
7678739-5	1993	This hypothesis was supported by the finding that inhibition of mitochondrial calcium uptake by Ruthenium Red exerted a protective effect on TNF alpha-treated L929 cells.	Ruthenium Red	96-109	tumor necrosis factor	Mus musculus	141-150
7692065-9	1993	Comparison with thapsigargin revealed that ruthenium red released Ca2+ from stores loaded to steady-state at a rate markedly faster than can be explained by inhibition of the ATPase alone.	Ruthenium Red	43-56	carbonic anhydrase 2	Oryctolagus cuniculus	66-69
7692065-10	1993	From the data presented, we concluded that ruthenium red selectively releases Ca2+ from the Ins(1,4,5)P3-sensitive store by activating a Ca2+ release channel, whereas Ca2+ release from the GTP-sensitive store is predominantly caused by inhibition of the Ca2+ pump.	Ruthenium Red	43-56	carbonic anhydrase 2	Oryctolagus cuniculus	78-81
7692065-10	1993	From the data presented, we concluded that ruthenium red selectively releases Ca2+ from the Ins(1,4,5)P3-sensitive store by activating a Ca2+ release channel, whereas Ca2+ release from the GTP-sensitive store is predominantly caused by inhibition of the Ca2+ pump.	Ruthenium Red	43-56	carbonic anhydrase 2	Oryctolagus cuniculus	137-140
7692065-10	1993	From the data presented, we concluded that ruthenium red selectively releases Ca2+ from the Ins(1,4,5)P3-sensitive store by activating a Ca2+ release channel, whereas Ca2+ release from the GTP-sensitive store is predominantly caused by inhibition of the Ca2+ pump.	Ruthenium Red	43-56	carbonic anhydrase 2	Oryctolagus cuniculus	137-140
7692065-10	1993	From the data presented, we concluded that ruthenium red selectively releases Ca2+ from the Ins(1,4,5)P3-sensitive store by activating a Ca2+ release channel, whereas Ca2+ release from the GTP-sensitive store is predominantly caused by inhibition of the Ca2+ pump.	Ruthenium Red	43-56	carbonic anhydrase 2	Oryctolagus cuniculus	137-140
7692065-11	1993	The postulated ruthenium red-sensitive Ca2+ release channel might be similar to the ryanodine-receptor in muscle.	Ruthenium Red	15-28	carbonic anhydrase 2	Oryctolagus cuniculus	39-42
7678245-5	1993	Yet, addition of ruthenium red immediately prior to FCCP or inclusion of acetate or low concentrations of phosphate in the incubation medium restore the ability of FCCP to trigger MTP opening.	Ruthenium Red	17-30	microsomal triglyceride transfer protein	Rattus norvegicus	180-183
7682749-5	1993	Ruthenium red (RR) significantly reduced the CGRP-LI release, but not the outflow of NPY-LI, at the highest dose of capsaicin as well as the functional effects evoked by low dose capsaicin administration.	Ruthenium Red	0-13	Calcitonin gene-related peptide	Sus scrofa	45-49
7682749-5	1993	Ruthenium red (RR) significantly reduced the CGRP-LI release, but not the outflow of NPY-LI, at the highest dose of capsaicin as well as the functional effects evoked by low dose capsaicin administration.	Ruthenium Red	15-17	Calcitonin gene-related peptide	Sus scrofa	45-49
1372874-4	1992	Electron microscopic examination of gonococci in eight exudates showed a surface structure stained by Ruthenium red which disappeared in most samples when they were treated with neuraminidase.	Ruthenium Red	102-115	neuraminidase 1	Homo sapiens	178-191
1280603-1	1992	Ruthenium red was found to inhibit actin-activated myosin Mg(2+)-ATPase in smooth muscle and to bind to myosin heavy chain, but not to F-actin.	Ruthenium Red	0-13	myosin heavy chain 14	Homo sapiens	104-110
1280603-2	1992	The inhibition by Ruthenium red of actin-activated Mg(2+)-ATPase was of the competitive type with respect to actin (Ki 4.4 microM) and of the non-competitive type with respect to ATP (Ki 6.6 microM).	Ruthenium Red	18-31	dynein axonemal heavy chain 8	Homo sapiens	58-64
1280603-3	1992	However, Ruthenium red scarcely dissociated the acto-heavy meromyosin complex during the ATPase reaction.	Ruthenium Red	9-22	dynein axonemal heavy chain 8	Homo sapiens	89-95
1280603-4	1992	These results suggest that Ruthenium red interacts directly with the binding site for F-actin on the myosin heavy chain.	Ruthenium Red	27-40	myosin heavy chain 14	Homo sapiens	101-107
1336328-5	1992	When cycling is prevented by Ca2+ chelators or by inhibition of the uptake route with ruthenium red, prooxidants still induce Ca2+ release but mitochondria remain intact.	Ruthenium Red	86-99	carbonic anhydrase 2	Homo sapiens	126-129
1279987-9	1992	Electron microscopy studies using apically applied ruthenium red suggest that TNF action results in < 10% of the junctions having increased permeability at any given time during the resistance decrease.	Ruthenium Red	51-64	tumor necrosis factor	Homo sapiens	78-81
1383224-4	1992	Ca2+ antagonizes the binding of ruthenium red to the low-affinity site on CaM.	Ruthenium Red	32-45	calmodulin 1	Homo sapiens	74-77
1383224-6	1992	The low- and high-affinity sites for ruthenium red are shown to be located in the NH2-terminal half and the COOH-terminal half of CaM, respectively.	Ruthenium Red	37-50	calmodulin 1	Homo sapiens	130-133
1383224-9	1992	These results suggest that ruthenium red may be a new type of CaM antagonist that inhibits the binding of Ca2+ to CaM and thereby inhibits Ca(2+)-CaM-dependent enzymes and smooth muscle contraction competitively with respect to Ca2+.	Ruthenium Red	27-40	calmodulin 1	Homo sapiens	62-65
1383224-9	1992	These results suggest that ruthenium red may be a new type of CaM antagonist that inhibits the binding of Ca2+ to CaM and thereby inhibits Ca(2+)-CaM-dependent enzymes and smooth muscle contraction competitively with respect to Ca2+.	Ruthenium Red	27-40	calmodulin 1	Homo sapiens	114-117
1383224-9	1992	These results suggest that ruthenium red may be a new type of CaM antagonist that inhibits the binding of Ca2+ to CaM and thereby inhibits Ca(2+)-CaM-dependent enzymes and smooth muscle contraction competitively with respect to Ca2+.	Ruthenium Red	27-40	calmodulin 1	Homo sapiens	114-117
1280603-0	1992	Inhibition of actin-activated myosin Mg(2+)-ATPase in smooth muscle by ruthenium red.	Ruthenium Red	71-84	myosin heavy chain 14	Homo sapiens	30-36
1280603-0	1992	Inhibition of actin-activated myosin Mg(2+)-ATPase in smooth muscle by ruthenium red.	Ruthenium Red	71-84	dynein axonemal heavy chain 8	Homo sapiens	44-50
1280603-1	1992	Ruthenium red was found to inhibit actin-activated myosin Mg(2+)-ATPase in smooth muscle and to bind to myosin heavy chain, but not to F-actin.	Ruthenium Red	0-13	myosin heavy chain 14	Homo sapiens	51-57
1280603-1	1992	Ruthenium red was found to inhibit actin-activated myosin Mg(2+)-ATPase in smooth muscle and to bind to myosin heavy chain, but not to F-actin.	Ruthenium Red	0-13	dynein axonemal heavy chain 8	Homo sapiens	65-71
1383224-0	1992	Ruthenium red inhibits the binding of calcium to calmodulin required for enzyme activation.	Ruthenium Red	0-13	calmodulin 1	Homo sapiens	49-59
1383224-1	1992	The Ca(2+)-calmodulin (CaM)-dependent activation of myosin light chain kinase is inhibited by ruthenium red competitively with respect to Ca2+, with a Ki value of 8.6 microM.	Ruthenium Red	94-107	calmodulin 1	Homo sapiens	11-21
1383224-1	1992	The Ca(2+)-calmodulin (CaM)-dependent activation of myosin light chain kinase is inhibited by ruthenium red competitively with respect to Ca2+, with a Ki value of 8.6 microM.	Ruthenium Red	94-107	calmodulin 1	Homo sapiens	23-26
1383224-1	1992	The Ca(2+)-calmodulin (CaM)-dependent activation of myosin light chain kinase is inhibited by ruthenium red competitively with respect to Ca2+, with a Ki value of 8.6 microM.	Ruthenium Red	94-107	myosin light chain kinase	Homo sapiens	52-77
1383224-2	1992	The binding of Ca2+ to CaM is inhibited by micromolar concentrations of ruthenium red.	Ruthenium Red	72-85	calmodulin 1	Homo sapiens	23-26
1383224-3	1992	In the absence of Ca2+, CaM has two binding sites for ruthenium red with the dissociation constants of 0.36 and 8.7 microM, respectively.	Ruthenium Red	54-67	calmodulin 1	Homo sapiens	24-27
1550349-11	1992	Hepatocytes treated with ruthenium red or fructose were less susceptible to TNF alpha-induced ATP depletion, which suggests that mitochondrial calcium cycling may be involved in disruption to energy metabolism.	Ruthenium Red	25-38	tumor necrosis factor	Mus musculus	76-85
1374925-8	1992	Release of CGRP evoked by capsaicin concentrations in the range of 0.1-0.3 microM in either dosage protocol was reduced in the presence of Ruthenium Red (RR, 2.5 microM).	Ruthenium Red	139-152	calcitonin-related polypeptide alpha	Rattus norvegicus	11-15
1706338-4	1991	Phosphorylation of the Ca2(+)-ATPase by Pi was also inhibited by ruthenium red and spermidine.	Ruthenium Red	65-78	dynein axonemal heavy chain 8	Homo sapiens	30-36
1724790-2	1991	A surface structure was visible on gonococci [strain BS4 (agar)] that had been stained with ruthenium red after incubation with CMP-NANA.	Ruthenium Red	92-105	negative regulator of ubiquitin like proteins 1	Homo sapiens	53-56
1831758-8	1991	In the absence of a Ca2+ gradient, trifluoperazine competes with the binding to the enzyme of both Pi and Mg2+, whereas spermidine and ruthenium red were found to compete only with Mg2+.	Ruthenium Red	135-148	mucin 7, secreted	Homo sapiens	181-184
1782213-8	1991	The PAF response was also inhibited by ruthenium red or octanol and potentiated by caffeine, suggesting that CICR plays a physiological role in these cells.	Ruthenium Red	39-52	PCNA clamp associated factor	Homo sapiens	4-7
1716572-5	1991	It is concluded that capsaicin excitation of primary afferents in the human ileum, leading to VIP release and muscle relaxation, occurs with mechanisms similar to those operating in animal tissues and that ruthenium red acts as a selective capsaicin antagonist in the human ileum.	Ruthenium Red	206-219	vasoactive intestinal peptide	Homo sapiens	94-97
1555728-1	1992	The action of pharmacological drugs (caffeine, procaine, ruthenium red) which influenced the release of Ca2+ from endoplasmatic reticulum, the electrical responses of dog pancreatic acinar cells was investigated using intracellular glass microelectrodes.	Ruthenium Red	57-70	carbonic anhydrase 2	Canis lupus familiaris	104-107
1724624-0	1991	Ruthenium-red inhibits CGRP release by capsaicin and resiniferatoxin but not by ouabain, bradykinin or nicotine in guinea-pig heart: correlation with effects on cardiac contractility.	Ruthenium Red	0-13	calcitonin related polypeptide alpha	Homo sapiens	23-27
1719004-8	1991	Morphological studies, using the glycocalyx stain ruthenium red, revealed that thrombin or cytochalasin D increased the penetration of the stain into junctions between endothelial cells.	Ruthenium Red	50-63	coagulation factor II, thrombin	Homo sapiens	79-87
1718773-8	1991	The capsaicin-induced relaxation was reproducible and it was concentration dependently inhibited by ruthenium red which suggests that capsaicin releases CGRP in the arterial wall.	Ruthenium Red	100-113	calcitonin related polypeptide alpha	Homo sapiens	153-157
1718522-10	1991	The relaxation was partly inhibited by ruthenium red, thus suggesting that capsaicin causes specific release of CGRP from sensory nerve endings in rat coronary arteries.	Ruthenium Red	39-52	calcitonin-related polypeptide alpha	Rattus norvegicus	112-116
1645250-9	1991	Ruthenium red, a voltage-independent calcium channel antagonist, was able to completely block uptake of 45Ca++ induced by hFSH-beta-(1-15) and hFSH-beta-(51-65) whereas nifedipine, a calcium channel blocker specific for L-type voltage-sensitive calcium channels, was without effect.	Ruthenium Red	0-13	follicle stimulating hormone subunit beta	Homo sapiens	122-131
1645250-9	1991	Ruthenium red, a voltage-independent calcium channel antagonist, was able to completely block uptake of 45Ca++ induced by hFSH-beta-(1-15) and hFSH-beta-(51-65) whereas nifedipine, a calcium channel blocker specific for L-type voltage-sensitive calcium channels, was without effect.	Ruthenium Red	0-13	follicle stimulating hormone subunit beta	Homo sapiens	143-152
1717894-0	1991	Ruthenium red selectively antagonizes capsaicin-induced release of vasoactive intestinal polypeptide (VIP) from the human colon.	Ruthenium Red	0-13	vasoactive intestinal peptide	Homo sapiens	67-100
1717894-0	1991	Ruthenium red selectively antagonizes capsaicin-induced release of vasoactive intestinal polypeptide (VIP) from the human colon.	Ruthenium Red	0-13	vasoactive intestinal peptide	Homo sapiens	102-105
1717894-2	1991	The aim of this study was to assess whether RR is able to antagonize the release of vasoactive intestinal polypeptide (VIP) evoked by capsaicin in the human colon.	Ruthenium Red	44-46	vasoactive intestinal peptide	Homo sapiens	84-117
1717894-2	1991	The aim of this study was to assess whether RR is able to antagonize the release of vasoactive intestinal polypeptide (VIP) evoked by capsaicin in the human colon.	Ruthenium Red	44-46	vasoactive intestinal peptide	Homo sapiens	119-122
1713165-4	1991	Ruthenium red, a blocker of mitochondrial Ca2+ reuptake, potently increased 3,4-DAP-evoked [3H]NA release in Ca(2+)-free EGTA-containing medium.	Ruthenium Red	0-13	death-associated protein	Rattus norvegicus	80-83
1702319-6	1990	Ruthenium red inhibited mitochondrial Ca buffering to effect increases in Cai in the absence of Ca chelators; it activated Nao-Cai exchange fluxes but had little effect on Cao-Nai exchange despite similar reported Km for Cai.	Ruthenium Red	0-13	carbonic anhydrase 1	Homo sapiens	74-77
2049806-5	1991	Regucalcin (2.0 microM)-induced stimulation of 45Ca2+ uptake was prevented by the presence of ruthenium red (1.0 microM) and lanthanum chloride (0.1 mM).	Ruthenium Red	94-107	regucalcin	Rattus norvegicus	0-10
1706431-4	1991	Procaine, ruthenium red or Mg++ caused concentration-dependent inhibition of MBED-triggered Ca++ release from HSR.	Ruthenium Red	10-23	HSR	Homo sapiens	110-113
1708823-8	1991	The response to low [Mg2+] was unaffected by inactivation of the voltage sensors, but was completely blocked by 2 microM-Ruthenium Red indicating that it involved Ca2+ efflux through the normal Ca2+ release channels.	Ruthenium Red	121-134	mucin 7, secreted	Homo sapiens	21-24
1707713-20	1991	Ruthenium red inhibits capsaicin-induced CGRP-LI release and functional effects and may thus serve as an experimental tool in evaluating the function of capsaicin-evoked stimulation of peripheral nerve terminals.	Ruthenium Red	0-13	calcitonin related polypeptide alpha	Homo sapiens	41-45
1702319-6	1990	Ruthenium red inhibited mitochondrial Ca buffering to effect increases in Cai in the absence of Ca chelators; it activated Nao-Cai exchange fluxes but had little effect on Cao-Nai exchange despite similar reported Km for Cai.	Ruthenium Red	0-13	carbonic anhydrase 1	Homo sapiens	127-130
1702319-6	1990	Ruthenium red inhibited mitochondrial Ca buffering to effect increases in Cai in the absence of Ca chelators; it activated Nao-Cai exchange fluxes but had little effect on Cao-Nai exchange despite similar reported Km for Cai.	Ruthenium Red	0-13	carbonic anhydrase 1	Homo sapiens	127-130
34562506-7	2021	When HYPX exposure and TRPV4 agonist (GSK1016790A)-induced TRPV4 activity were inhibited by the treatment of ruthenium red or MLT, the increase of mROS, lipid peroxidation, apoptosis, Zn2+ concentrations, TRPV4, caspase -3, caspase -9, Bax, and Bcl-2 expressions were restored via upregulation of reduced glutathione, glutathione peroxidase and total antioxidant status.	Ruthenium Red	109-122	transient receptor potential cation channel subfamily V member 4	Homo sapiens	23-28
1700314-5	1990	Ruthenium red, but not orthovanadate, abolished the slow decline of free Ca2+ concentration after the initial increase.	Ruthenium Red	0-13	carbonic anhydrase 2	Homo sapiens	73-76
24911002-7	2015	GSK- and PMA-induced Ca(2+) elevations were inhibited by RN-1734 and ruthenium red, which selectively target TRPV4 in mature endothelium.	Ruthenium Red	69-82	transient receptor potential cation channel subfamily V member 4	Homo sapiens	109-114
17498734-11	2007	Importantly, both (i) 20 microM ruthenium red, a selective inhibitor of SR Ca2+ -release, and (ii) depleting SR by application of 10 microM ryanodine+1 mM caffeine, abolished the activation of IK1 by CN.	Ruthenium Red	32-45	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	193-196
1702040-8	1990	The ability of GM1 to enhance neuritogenesis was diminished by EGTA or Ruthenium red.	Ruthenium Red	71-84	coenzyme Q10A	Mus musculus	15-18
1693502-2	1990	Increasing calmodulin concentration in the presence of both 100 microM and 4000 microM Ca2+ completely reversed the inhibition of Ca2(+)-PDE activity by ruthenium red.	Ruthenium Red	153-166	calmodulin 1	Homo sapiens	11-21
1693502-3	1990	Ruthenium red-induced inhibition of Ca2(+)-PDE activity was also overcome by increasing the concentration of Ca2+ in the presence of both 200 ng and 2000 ng calmodulin, in sharp contrast to fluphenazine-induced inhibition of Ca2(+)-PDE.	Ruthenium Red	0-13	calmodulin 1	Homo sapiens	157-167
2190805-7	1990	Recent studies with rat hepatocytes show that ruthenium red (RR) and La3+, which block Ca2+ translocation through the mitochondrial uniport, can prevent malondialdehyde (MDA) formation, reduced glutathione (GSH), and protein-SH loss, Vit.	Ruthenium Red	46-59	vitrin	Rattus norvegicus	234-237
2190805-7	1990	Recent studies with rat hepatocytes show that ruthenium red (RR) and La3+, which block Ca2+ translocation through the mitochondrial uniport, can prevent malondialdehyde (MDA) formation, reduced glutathione (GSH), and protein-SH loss, Vit.	Ruthenium Red	61-63	vitrin	Rattus norvegicus	234-237
1723514-5	1990	The action of resiniferatoxin was blocked by Ruthenium Red, a proposed antagonist at the cation channel coupled to the capsaicin receptor.	Ruthenium Red	45-58	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	119-137
21938744-6	2012	Blocking of TRPV4 by ruthenium red abolished calcium influx as well as RVD, identifying TRPV4 as a necessary component in volume regulation.	Ruthenium Red	21-34	transient receptor potential cation channel subfamily V member 4	Homo sapiens	12-17
34562506-7	2021	When HYPX exposure and TRPV4 agonist (GSK1016790A)-induced TRPV4 activity were inhibited by the treatment of ruthenium red or MLT, the increase of mROS, lipid peroxidation, apoptosis, Zn2+ concentrations, TRPV4, caspase -3, caspase -9, Bax, and Bcl-2 expressions were restored via upregulation of reduced glutathione, glutathione peroxidase and total antioxidant status.	Ruthenium Red	109-122	transient receptor potential cation channel subfamily V member 4	Homo sapiens	59-64
34562506-7	2021	When HYPX exposure and TRPV4 agonist (GSK1016790A)-induced TRPV4 activity were inhibited by the treatment of ruthenium red or MLT, the increase of mROS, lipid peroxidation, apoptosis, Zn2+ concentrations, TRPV4, caspase -3, caspase -9, Bax, and Bcl-2 expressions were restored via upregulation of reduced glutathione, glutathione peroxidase and total antioxidant status.	Ruthenium Red	109-122	transient receptor potential cation channel subfamily V member 4	Homo sapiens	205-210
34562506-7	2021	When HYPX exposure and TRPV4 agonist (GSK1016790A)-induced TRPV4 activity were inhibited by the treatment of ruthenium red or MLT, the increase of mROS, lipid peroxidation, apoptosis, Zn2+ concentrations, TRPV4, caspase -3, caspase -9, Bax, and Bcl-2 expressions were restored via upregulation of reduced glutathione, glutathione peroxidase and total antioxidant status.	Ruthenium Red	109-122	caspase 3	Homo sapiens	212-222
34562506-7	2021	When HYPX exposure and TRPV4 agonist (GSK1016790A)-induced TRPV4 activity were inhibited by the treatment of ruthenium red or MLT, the increase of mROS, lipid peroxidation, apoptosis, Zn2+ concentrations, TRPV4, caspase -3, caspase -9, Bax, and Bcl-2 expressions were restored via upregulation of reduced glutathione, glutathione peroxidase and total antioxidant status.	Ruthenium Red	109-122	caspase 9	Homo sapiens	224-234
34562506-7	2021	When HYPX exposure and TRPV4 agonist (GSK1016790A)-induced TRPV4 activity were inhibited by the treatment of ruthenium red or MLT, the increase of mROS, lipid peroxidation, apoptosis, Zn2+ concentrations, TRPV4, caspase -3, caspase -9, Bax, and Bcl-2 expressions were restored via upregulation of reduced glutathione, glutathione peroxidase and total antioxidant status.	Ruthenium Red	109-122	BCL2 associated X, apoptosis regulator	Homo sapiens	236-239
34562506-7	2021	When HYPX exposure and TRPV4 agonist (GSK1016790A)-induced TRPV4 activity were inhibited by the treatment of ruthenium red or MLT, the increase of mROS, lipid peroxidation, apoptosis, Zn2+ concentrations, TRPV4, caspase -3, caspase -9, Bax, and Bcl-2 expressions were restored via upregulation of reduced glutathione, glutathione peroxidase and total antioxidant status.	Ruthenium Red	109-122	BCL2 apoptosis regulator	Homo sapiens	245-250
34608683-3	2022	In this study, we examined the efficacy of cutting off nails and TRPV1 antagonist, ruthenium red (RR) in a murine model of AD induced by DNFB and further investigated the underlying mechanism.	Ruthenium Red	83-96	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-70
34725357-0	2021	Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.	Ruthenium Red	45-58	transient receptor potential cation channel subfamily V member 6	Homo sapiens	25-30
34725357-3	2021	Here we combine cryo-EM, calcium imaging, and mutagenesis to explore molecular bases of human TRPV6 inhibition by the antifungal drug econazole and the universal ion channel blocker ruthenium red (RR).	Ruthenium Red	182-195	transient receptor potential cation channel subfamily V member 6	Homo sapiens	94-99
34725357-3	2021	Here we combine cryo-EM, calcium imaging, and mutagenesis to explore molecular bases of human TRPV6 inhibition by the antifungal drug econazole and the universal ion channel blocker ruthenium red (RR).	Ruthenium Red	197-199	transient receptor potential cation channel subfamily V member 6	Homo sapiens	94-99
35623885-6	2022	Blockade of the primary route for Zn2+ entry, the mitochondrial Ca2+ uniporter (MCU; with ruthenium red, RR) or Zn2+ chelation shortly after OGD withdrawal substantially attenuated the mitochondrial depolarization and the changes in synaptic activity.	Ruthenium Red	90-103	carbonic anhydrase 2	Rattus norvegicus	64-67
35623885-6	2022	Blockade of the primary route for Zn2+ entry, the mitochondrial Ca2+ uniporter (MCU; with ruthenium red, RR) or Zn2+ chelation shortly after OGD withdrawal substantially attenuated the mitochondrial depolarization and the changes in synaptic activity.	Ruthenium Red	90-103	mitochondrial calcium uniporter	Rattus norvegicus	80-83
35406761-7	2022	This enhancement was blocked by the TRPV2 nonspecific inhibitor ruthenium red and by TRPV2-specific small interfering (si)RNA transfection.	Ruthenium Red	64-77	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	36-41
34989943-12	2022	TRPV4 is activated by the treatments of GSK1016790A (GSK), although it is inhibited by a nonspecific inhibitor (ruthenium red, RuRe).	Ruthenium Red	112-125	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
2461981-3	1989	However, polarized apical expression of MAM-6 is restored as early as 2-6 hr after plating of unpolarized cells, before functional tight junctions are established, as judged by freeze-fracture and ruthenium red permeability.	Ruthenium Red	197-210	mucin 1, cell surface associated	Homo sapiens	40-45
2476183-3	1989	The rapid phase of Ca2+-release induced by Ag+ is activated by millimolar ATP and inhibited by 5 microM ruthenium red.	Ruthenium Red	104-117	carbonic anhydrase 2	Homo sapiens	19-22
2462926-16	1988	The Ca2+-release channel studied using this method exhibits two predominant conductance levels (80-100 pS and 120-160 pS), conducts Ca2+ preferentially over K+ (PCa/Pk = 6.5), is highly voltage sensitive, blocked on one side by ruthenium red (1 microM), and displays enhanced activity in the presence of caffeine (5 mM).	Ruthenium Red	228-241	ryanodine receptor 2	Oryctolagus cuniculus	4-24
2447088-5	1988	), the development of nonspecific permeability produced by ruthenium red plus uncoupler requires accumulated Ca2+ specifically and is antagonized by inhibitors of phospholipase A2.	Ruthenium Red	59-72	phospholipase A2 group IB	Rattus norvegicus	163-179
3267206-2	1988	In most experiments, ruthenium red was used to inhibit mitochondrial Ca2+ uptake.	Ruthenium Red	21-34	carbonic anhydrase 2	Rattus norvegicus	69-72
3828398-4	1987	The activity depended upon the presence of ruthenium red, which prevented recycling of Ca2+; comparison of the activity with A23187 and carbonyl cyanide p-trifluoromethoxyphenylhydrazone indicated that the prostaglandin B1 oligomers were functioning as ionophores and the release of Ca2+ was not caused by an uncoupling of oxidative phosphorylation.	Ruthenium Red	43-56	carbonic anhydrase 2	Rattus norvegicus	87-90
3828398-4	1987	The activity depended upon the presence of ruthenium red, which prevented recycling of Ca2+; comparison of the activity with A23187 and carbonyl cyanide p-trifluoromethoxyphenylhydrazone indicated that the prostaglandin B1 oligomers were functioning as ionophores and the release of Ca2+ was not caused by an uncoupling of oxidative phosphorylation.	Ruthenium Red	43-56	carbonic anhydrase 2	Rattus norvegicus	283-286
2423127-4	1986	If Ca2+ cycling was prevented by ruthenium red, the changes in delta psi, the rate of respiration and the extent of mitochondrial swelling were significantly diminished.	Ruthenium Red	33-46	carbonic anhydrase 2	Rattus norvegicus	3-6
2436608-6	1987	Treatment of the cells with Ruthenium Red, an inhibitor of Ca2+ transport into mitochondria, largely prevents an increase in PDHA in response to addition of KCl or of veratridine plus ouabain.	Ruthenium Red	28-41	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	125-129
3749242-8	1986	Besides, ruthenium red is a membrane inorganic dye known to bind and inhibit some calcium carriers (mitochondrial carrier, ATP ase calcium dependent from sarcoplasmic reticulum and erythrocyte).	Ruthenium Red	9-22	dynein axonemal heavy chain 8	Homo sapiens	123-130
3760755-9	1986	Collagen was coated with granules (probably proteoglycan) at periodic intervals when stained with ruthenium red.	Ruthenium Red	98-111	collagen type III alpha 1 chain	Gallus gallus	0-8
3760755-9	1986	Collagen was coated with granules (probably proteoglycan) at periodic intervals when stained with ruthenium red.	Ruthenium Red	98-111	versican	Gallus gallus	44-56
2423142-3	1986	The caffeine-induced transport of Ca2+ is blocked by ruthenium red, tetracaine and dimethylsulfoxide.	Ruthenium Red	53-66	carbonic anhydrase 2	Oryctolagus cuniculus	34-37
2422345-4	1986	On the other hand, ruthenium red, an inhibitor of calcium uptake, stimulated PCM activity.	Ruthenium Red	19-32	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	77-80
3484527-7	1986	Transmission electron microscopy images of late LPC-1 cells suggested an active protein synthesis which correlated with a more intense deposition of ruthenium red and an increasing amount of gp160 on the cell surface.	Ruthenium Red	149-162	annexin A1	Mus musculus	48-53
2425861-0	1986	Dissociation of insulin binding from insulin stimulation of 2-deoxyglucose transport by ruthenium red.	Ruthenium Red	88-101	insulin	Homo sapiens	37-44
2425861-1	1986	Ruthenium red increased specific insulin binding to isolated adipocytes 5.4 fold and 2.6 fold over binding determined in the absence and presence of Ca2+ and Mg2+.	Ruthenium Red	0-13	insulin	Homo sapiens	33-40
4063356-4	1985	Ca2+ release from terminal cisternae vesicles induced by halothane is inhibited by Ruthenium red and Mg2+, and require ATP (or an ATP analogue), KCl (or similar salt) and extravesicular Ca2+.	Ruthenium Red	83-96	carbonic anhydrase 2	Rattus norvegicus	0-3
2430346-0	1986	Antidiuretic hormone response in the amphibian urinary bladder: time course of cytochalasin-induced vacuole formation, an ultrastructural study employing ruthenium red.	Ruthenium Red	154-167	arginine vasopressin	Homo sapiens	0-20
3907405-7	1985	In these experiments it is shown that with mitochondria from all tissues a steady-state ambient free Ca2+ concentration between 0.6 and 0.8 microM is reached, though the Na+ sensitivity of ruthenium red-induced Ca2+ efflux from these mitochondria varies considerably in dependence on the tissue.	Ruthenium Red	189-202	carbonic anhydrase 2	Rattus norvegicus	101-104
2412581-1	1985	The release of Ca2+ from respiring rat liver mitochondria following the addition of either ruthenium red or an uncoupler was measured by a Ca2+-selective electrode or by 45Ca2+ technique.	Ruthenium Red	91-104	carbonic anhydrase 2	Rattus norvegicus	15-18
2412581-1	1985	The release of Ca2+ from respiring rat liver mitochondria following the addition of either ruthenium red or an uncoupler was measured by a Ca2+-selective electrode or by 45Ca2+ technique.	Ruthenium Red	91-104	carbonic anhydrase 2	Rattus norvegicus	139-142
2412581-6	1985	Ba2+ accumulation is mediated through the Ca2+ uniporter as 140Ba2+ uptake was competitively inhibited by extramitochondrial Ca2+ and prevented by ruthenium red.	Ruthenium Red	147-160	carbonic anhydrase 2	Rattus norvegicus	42-45
2412581-7	1985	Due to the inhibition of the ruthenium red insensitive Ca2+ release, Ba2+ shifted the steady-state extramitochondrial Ca2+ concentration to a lower value.	Ruthenium Red	29-42	carbonic anhydrase 2	Rattus norvegicus	118-121
3907405-7	1985	In these experiments it is shown that with mitochondria from all tissues a steady-state ambient free Ca2+ concentration between 0.6 and 0.8 microM is reached, though the Na+ sensitivity of ruthenium red-induced Ca2+ efflux from these mitochondria varies considerably in dependence on the tissue.	Ruthenium Red	189-202	carbonic anhydrase 2	Rattus norvegicus	211-214
2411223-1	1985	Ruthenium red-insensitive, uncoupler-stimulated release of Ca2+ from Ehrlich ascites tumor cell mitochondria is much slower than from rat liver mitochondria under comparable conditions.	Ruthenium Red	0-13	carbonic anhydrase 2	Mus musculus	59-62
2411223-2	1985	In the presence of Pi and at moderate or high Ca2+ loads, ruthenium red-insensitive Ca2+ efflux elicited with uncoupler is approximately 20 times more rapid for rat liver than Ehrlich cell mitochondria.	Ruthenium Red	58-71	carbonic anhydrase 2	Rattus norvegicus	46-49
2411223-2	1985	In the presence of Pi and at moderate or high Ca2+ loads, ruthenium red-insensitive Ca2+ efflux elicited with uncoupler is approximately 20 times more rapid for rat liver than Ehrlich cell mitochondria.	Ruthenium Red	58-71	carbonic anhydrase 2	Rattus norvegicus	84-87
2411223-13	1985	Ruthenium red-insensitive Ca2+ efflux, when expressed as a function of the intramitochondrial Ca2+/Mg2+ ratio, is quite similar for tumor and rat liver.	Ruthenium Red	0-13	carbonic anhydrase 2	Rattus norvegicus	26-29
2411223-13	1985	Ruthenium red-insensitive Ca2+ efflux, when expressed as a function of the intramitochondrial Ca2+/Mg2+ ratio, is quite similar for tumor and rat liver.	Ruthenium Red	0-13	carbonic anhydrase 2	Rattus norvegicus	94-97
2578123-0	1985	Effects of phospholipase A2 inhibitors on ruthenium red-induced Ca2+ release from mitochondria.	Ruthenium Red	42-55	phospholipase A2 group IB	Rattus norvegicus	11-27
2581558-8	1985	Experiments in which synaptosomes were treated with Ruthenium Red, an inhibitor of mitochondrial Ca2+ uptake, gave much lower resting contents of PDHA (42 +/- 2% of maximal), but failed to prevent totally an increase on depolarization.	Ruthenium Red	52-65	carbonic anhydrase 2	Rattus norvegicus	97-100
6489346-3	1984	The swelling is inhibited by ruthenium red, suggesting that this effect of Cd2+ requires its entry into mitochondria.	Ruthenium Red	29-42	CD2 molecule	Homo sapiens	75-78
6201430-10	1984	Ruthenium red and EGTA protected mitochondria from the destructive Ca2+ release and induced an immediate, slow release of Ca2+ and phosphate.	Ruthenium Red	0-13	carbonic anhydrase 2	Rattus norvegicus	67-70
6324751-3	1984	It is concluded that all three enzymes may be activated by increases in the intramitochondrial concentration of Ca2+ and that the distribution of Ca2+ across the mitochondrial inner membrane is determined, as in rat heart mitochondria, by the relative activities of a uniporter (which transports Ca2+ into mitochondria and is inhibited by Mg2+ and Ruthenium Red) and an antiporter (which allows Ca2+ to leave mitochondria in exchange for Na+ and is inhibited by diltiazem).	Ruthenium Red	348-361	carbonic anhydrase 2	Rattus norvegicus	146-149
6324751-3	1984	It is concluded that all three enzymes may be activated by increases in the intramitochondrial concentration of Ca2+ and that the distribution of Ca2+ across the mitochondrial inner membrane is determined, as in rat heart mitochondria, by the relative activities of a uniporter (which transports Ca2+ into mitochondria and is inhibited by Mg2+ and Ruthenium Red) and an antiporter (which allows Ca2+ to leave mitochondria in exchange for Na+ and is inhibited by diltiazem).	Ruthenium Red	348-361	carbonic anhydrase 2	Rattus norvegicus	146-149
6324751-3	1984	It is concluded that all three enzymes may be activated by increases in the intramitochondrial concentration of Ca2+ and that the distribution of Ca2+ across the mitochondrial inner membrane is determined, as in rat heart mitochondria, by the relative activities of a uniporter (which transports Ca2+ into mitochondria and is inhibited by Mg2+ and Ruthenium Red) and an antiporter (which allows Ca2+ to leave mitochondria in exchange for Na+ and is inhibited by diltiazem).	Ruthenium Red	348-361	carbonic anhydrase 2	Rattus norvegicus	146-149
6324751-7	1984	However, the increases caused by high [Ca2+] in the medium were blocked by Ruthenium Red, whereas those caused by insulin were not.	Ruthenium Red	75-88	carbonic anhydrase 2	Rattus norvegicus	39-42
6202338-3	1984	Ruthenium red inhibits the respiratory-inhibitor- or uncoupler-induced Sr2+ efflux from STM, but not the Ca2+ efflux from standard mitochondria.	Ruthenium Red	0-13	sulfotransferase family 1A member 1	Rattus norvegicus	88-91
6201430-10	1984	Ruthenium red and EGTA protected mitochondria from the destructive Ca2+ release and induced an immediate, slow release of Ca2+ and phosphate.	Ruthenium Red	0-13	carbonic anhydrase 2	Rattus norvegicus	122-125
6190435-0	1983	Ruthenium red-sensitive and -insensitive release of Ca2+ from uncoupled heart mitochondria.	Ruthenium Red	0-13	carbonic anhydrase 2	Homo sapiens	52-55
6661437-2	1983	First, when a pulse of acid is added to a suspension of mitochondria loaded with Ca2+, a pulse of intramitochondrial Ca2+ is often released, even in the presence of the inhibitor of mitochondrial Ca2+ influx, ruthenium red.	Ruthenium Red	209-222	carbonic anhydrase 2	Rattus norvegicus	117-120
6661437-2	1983	First, when a pulse of acid is added to a suspension of mitochondria loaded with Ca2+, a pulse of intramitochondrial Ca2+ is often released, even in the presence of the inhibitor of mitochondrial Ca2+ influx, ruthenium red.	Ruthenium Red	209-222	carbonic anhydrase 2	Rattus norvegicus	117-120
6661437-3	1983	Second, at a pH near 7, the stoichiometry of Ca2+ released to H+ taken up by Ca2+-loaded mitochondria, following treatment with ruthenium red, has been observed to be 1:2.	Ruthenium Red	128-141	carbonic anhydrase 2	Rattus norvegicus	45-48
6661437-3	1983	Second, at a pH near 7, the stoichiometry of Ca2+ released to H+ taken up by Ca2+-loaded mitochondria, following treatment with ruthenium red, has been observed to be 1:2.	Ruthenium Red	128-141	carbonic anhydrase 2	Rattus norvegicus	77-80
6190435-1	1983	The uncoupler-induced release of accumulated Ca2+ from heart mitochondria can be separated into two components, one sensitive and one insensitive to ruthenium red.	Ruthenium Red	149-162	carbonic anhydrase 2	Homo sapiens	45-48
6190435-2	1983	In mitochondria maintaining reduced NAD(P)H pools and adequate levels of endogenous adenine nucleotides, the release of Ca2+ following addition of an uncoupler is virtually all inhibited by ruthenium red and can be presumed to occur via reversal of the Ca2+ uniporter.	Ruthenium Red	190-203	carbonic anhydrase 2	Homo sapiens	120-123
6190435-2	1983	In mitochondria maintaining reduced NAD(P)H pools and adequate levels of endogenous adenine nucleotides, the release of Ca2+ following addition of an uncoupler is virtually all inhibited by ruthenium red and can be presumed to occur via reversal of the Ca2+ uniporter.	Ruthenium Red	190-203	carbonic anhydrase 2	Homo sapiens	253-256
6190435-3	1983	When ruthenium red is added to block efflux via this pathway, high rates of Ca2+ efflux can still be induced by an uncoupler, provided either NADH is oxidized or mitochondrial adenine nucleotide pools are depleted by prior treatment.	Ruthenium Red	5-18	carbonic anhydrase 2	Homo sapiens	76-79
6190435-4	1983	This ruthenium red-insensitive Ca2+-efflux pathway is dependent on the level of Ca2+ accumulated and is accompanied by swelling of the mitochondria and loss of endogenous Mg2+.	Ruthenium Red	5-18	carbonic anhydrase 2	Homo sapiens	31-34
6190435-4	1983	This ruthenium red-insensitive Ca2+-efflux pathway is dependent on the level of Ca2+ accumulated and is accompanied by swelling of the mitochondria and loss of endogenous Mg2+.	Ruthenium Red	5-18	carbonic anhydrase 2	Homo sapiens	80-83
6293824-2	1982	The rate of ruthenium-red-insensitive Ca2+ efflux is continuously increased during the retention as a result of induction of an electroneutral H+ Ca2+ exchange system.	Ruthenium Red	12-25	carbonic anhydrase 2	Rattus norvegicus	38-41
6186767-4	1983	Ruthenium red (10 microM), known to inhibit Ca2+-entry into mitochondria, enhanced veratrine-induced [3H]noradrenaline release.	Ruthenium Red	0-13	carbonic anhydrase 2	Rattus norvegicus	44-47
7152023-1	1982	The hydroperoxide-induced net release of Ca2+ from rat liver mitochondria is stimulated by the Ca2+ uptake inhibitor ruthenium red.	Ruthenium Red	117-130	carbonic anhydrase 2	Rattus norvegicus	41-44
7152023-1	1982	The hydroperoxide-induced net release of Ca2+ from rat liver mitochondria is stimulated by the Ca2+ uptake inhibitor ruthenium red.	Ruthenium Red	117-130	carbonic anhydrase 2	Rattus norvegicus	95-98
6293824-2	1982	The rate of ruthenium-red-insensitive Ca2+ efflux is continuously increased during the retention as a result of induction of an electroneutral H+ Ca2+ exchange system.	Ruthenium Red	12-25	carbonic anhydrase 2	Rattus norvegicus	146-149
6166353-5	1981	In contrast, ruthenium red counteracted the ionophore induced inhibition of AXT.	Ruthenium Red	13-26	contactin 2	Homo sapiens	76-79
6176579-3	1982	A23187, carbonyl cyanide p-trifluoromethoxyphenylhydrazone, or Na+ induced a release of Ca2+ from Ca2+-loaded and ruthenium red (RR)-treated mitochondria.	Ruthenium Red	114-127	carbonic anhydrase 2	Oryctolagus cuniculus	88-91
6176579-3	1982	A23187, carbonyl cyanide p-trifluoromethoxyphenylhydrazone, or Na+ induced a release of Ca2+ from Ca2+-loaded and ruthenium red (RR)-treated mitochondria.	Ruthenium Red	129-131	carbonic anhydrase 2	Oryctolagus cuniculus	88-91
6176579-6	1982	In the absence of RR, the net amount of Ca2+ released by Na+ was less than that which occurred in the presence of RR due to the simultaneous operation of both the Ca2+ uptake and the Ca2+ release processes.	Ruthenium Red	114-116	carbonic anhydrase 2	Oryctolagus cuniculus	163-166
6176579-6	1982	In the absence of RR, the net amount of Ca2+ released by Na+ was less than that which occurred in the presence of RR due to the simultaneous operation of both the Ca2+ uptake and the Ca2+ release processes.	Ruthenium Red	114-116	carbonic anhydrase 2	Oryctolagus cuniculus	163-166
6281099-5	1982	The Ca2+ antagonists verapamil (10-4 M), methoxy-verapamil (10-4 M) and La3+ (10-3 M) inhibited the dispersion induced by 3 X 10-9 M alpha-MSH, whereas ruthenium red (10-3 M) was without effect.	Ruthenium Red	152-165	proopiomelanocortin S homeolog	Xenopus laevis	133-142
6174564-7	1982	Chondroitinase treatment removed almost all of the ruthenium red-positive material in the EN basal lamina; lysozyme binding here was markedly reduced.	Ruthenium Red	51-64	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	0-14
6286128-5	1981	S100 in its calcium form reacts with the membrane and increases GABA transport by 20% which is ATP dependent and inhibited by ouabain and ruthenium red.	Ruthenium Red	138-151	S100 calcium binding protein A1	Homo sapiens	0-4
6177691-3	1982	When ruthenium red is added after Ca2+ uptake, but before the releasing agent, the extent of Ca2+ release is diminished as is the extent of Mg2+ and K+ depletion and the extent of swelling.	Ruthenium Red	5-18	mucin 7, secreted	Homo sapiens	140-143
6177691-5	1982	When Ca2+ release is induced by oxalacetate or t-butyl hydroperoxide and ruthenium red is added subsequently, an apparent regeneration of membrane potential is observed providing that the associated swelling and Mg2+ loss had not been completed at the time ruthenium red was added.	Ruthenium Red	73-86	mucin 7, secreted	Homo sapiens	212-215
6171308-4	1981	The adsorption of H+ by mitochondria is inhibited by ruthenium red and other specific inhibitors of Ca2+ transport.	Ruthenium Red	53-66	carbonic anhydrase 2	Rattus norvegicus	100-103
6163856-8	1981	Ruthenium red antagonized calmodulin-activated and basal activity with equal potency.	Ruthenium Red	0-13	calmodulin 1	Homo sapiens	26-36
6169688-1	1981	Specific detection of iota-Carrageenan (i-CAR) at the ultrastructural level has been obtained by coupling with ruthenium red (RR) - an electron microscopic stain.	Ruthenium Red	111-124	CXADR pseudogene 1	Homo sapiens	42-45
6169688-1	1981	Specific detection of iota-Carrageenan (i-CAR) at the ultrastructural level has been obtained by coupling with ruthenium red (RR) - an electron microscopic stain.	Ruthenium Red	126-128	CXADR pseudogene 1	Homo sapiens	42-45
36390-1	1979	Simultaneous measurements of oxygen consumption and transmembrane transport of Ca2+, H+, and phosphate show that the efflux of Ca2+ from respiring tightly coupled rat liver mitochondria takes place by an electroneutral Ca2+/2H+ antiport process that is ruthenium red-insensitive and that is regulated by the oxidation-reduction state of the mitochondrial pyridine nucleotides.	Ruthenium Red	253-266	carbonic anhydrase 2	Rattus norvegicus	79-82
36390-1	1979	Simultaneous measurements of oxygen consumption and transmembrane transport of Ca2+, H+, and phosphate show that the efflux of Ca2+ from respiring tightly coupled rat liver mitochondria takes place by an electroneutral Ca2+/2H+ antiport process that is ruthenium red-insensitive and that is regulated by the oxidation-reduction state of the mitochondrial pyridine nucleotides.	Ruthenium Red	253-266	carbonic anhydrase 2	Rattus norvegicus	127-130
36390-1	1979	Simultaneous measurements of oxygen consumption and transmembrane transport of Ca2+, H+, and phosphate show that the efflux of Ca2+ from respiring tightly coupled rat liver mitochondria takes place by an electroneutral Ca2+/2H+ antiport process that is ruthenium red-insensitive and that is regulated by the oxidation-reduction state of the mitochondrial pyridine nucleotides.	Ruthenium Red	253-266	carbonic anhydrase 2	Rattus norvegicus	127-130
36390-4	1979	Upon subsequent addition of ruthenium red to block Ca2+ transport via the electrophoretic influx pathway, and acetoacetate, to bring mitochondrial pyridine nucleotides into the oxidized state, Ca2+ efflux and H+ influx ensued.	Ruthenium Red	28-41	carbonic anhydrase 2	Rattus norvegicus	51-54
36390-4	1979	Upon subsequent addition of ruthenium red to block Ca2+ transport via the electrophoretic influx pathway, and acetoacetate, to bring mitochondrial pyridine nucleotides into the oxidized state, Ca2+ efflux and H+ influx ensued.	Ruthenium Red	28-41	carbonic anhydrase 2	Rattus norvegicus	193-196
314624-13	1979	Subsequent treatment of the neuraminidase-treated muscles with 30 microns of ruthenium red has no further effect on contraction threshold.	Ruthenium Red	77-90	neuraminidase 1	Homo sapiens	28-41
711630-8	1978	Addition of ruthenium red reversed divalent cation ionophore-induced swelling and released Ca2+ from preloaded mitochondria.	Ruthenium Red	12-25	carbonic anhydrase 2	Homo sapiens	91-94
336090-4	1977	In mitochondria, the neutral ionophore promotes the active transport of Ca2+ in response to the negative membrane potential generated by respiration, in the presence of the specific inhibitor of the natural carrier ruthenium red.	Ruthenium Red	215-228	carbonic anhydrase 2	Homo sapiens	72-75
153028-3	1978	Ruthenium red and hexamine cobalt in a concentration of 10(-4) inhibit this ATPase activity by 50-60%.	Ruthenium Red	0-13	dynein axonemal heavy chain 8	Homo sapiens	76-82
149451-0	1978	Inhibition of Mg, Ca-ATPase from E. coli by ruthenium red.	Ruthenium Red	44-57	ATPase	Escherichia coli	21-27
149451-1	1978	The membrane-bound, solubilized, and trypsin-treated forms of Mg, Ca-ATPase from E. coli are inhibited by ruthenium red [RR].	Ruthenium Red	106-119	ATPase	Escherichia coli	69-75
588575-3	1977	Conversely, ruthenium red blocks Ca2+ uptake and H+ production but does not prevent dinitrophenol-induced Ca2+ efflux and H+ uptake by mitochondria.	Ruthenium Red	12-25	carbonic anhydrase 2	Sus scrofa	33-36
588575-5	1977	The efflux of Ca2+ from mitochondria is mediated by a bongkrekic acid sensitive component which is apparently not identical to the ruthenium red sensitive Ca2+ uptake carrier.	Ruthenium Red	131-144	carbonic anhydrase 2	Sus scrofa	14-17
240699-1	1975	This report describes a kinetic analysis of energy-linked Ca2+ transport in rat liver mitochondria, in which a ruthenium red/EGTA [ethanedioxy-bis(ethylamine)-tetraacetic acid] quenching technique has been used to measure rates of 45Ca2+ transport.	Ruthenium Red	111-124	carbonic anhydrase 2	Rattus norvegicus	58-61
1276140-8	1976	Ruthenium red is a powerful inhibitor of ATP dependent Mg2+ flux.	Ruthenium Red	0-13	mucin 7, secreted	Homo sapiens	55-58
127016-8	1975	Ruthenium red-positive materials at mesenchymal cell surfaces display sensitivity to testicular hyaluronidase, Pronase and trypsin but resist removal with neuraminidase and EDTA.	Ruthenium Red	0-13	neuraminidase 1	Homo sapiens	155-168
12556-5	1976	The energy-independent accumulation of iron-transferrin reveals no saturation kinetics, it is inhibited neither by ruthenium red nor by N-ethylmaleimide, and it proceeds linearly for at least 90 min.	Ruthenium Red	115-128	transferrin	Rattus norvegicus	44-55
33733088-9	2021	5 muM of ruthenium red was used as an efficient blocker of ionic current through TRPV4 channels.	Ruthenium Red	9-22	transient receptor potential cation channel subfamily V member 4	Homo sapiens	81-86
807204-4	1975	5 muM) and high affinity for the Ca-2+-transport inhibitoy, Ruthenium Red (approx.	Ruthenium Red	60-73	carbonic anhydrase 2	Rattus norvegicus	33-38
33827677-10	2021	We conclude that RuR has a decreased affinity for guinea pig TRPA1 compared to mouse TRPA1.	Ruthenium Red	17-20	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	61-66
4357869-2	1973	Ruthenium Red (2.5-10.0 muM) reduces the synaptic potential to subthreshold levels.	Ruthenium Red	0-13	latexin	Homo sapiens	24-27
33901737-9	2021	Studies with Ca2+ channel inhibitors, Ruthenium Red and 2-Aminoethoxydiphenyl borate, lowers the inhibitory effects of 7HF on CD4+ T cell and macrophage responses.	Ruthenium Red	38-51	CD4 molecule	Homo sapiens	126-129
33321111-7	2021	Our results also revealed that Ca2+ finally transited in mitochondria through mitochondrial Ca2+ uniporter (MCU), causing I3M-mediated paraptosis; however, the paraptosis was completely inhibited by, ruthenium red, an MCU inhibitor.	Ruthenium Red	200-213	mitochondrial calcium uniporter	Homo sapiens	218-221
33161753-4	2021	Disruption in the filling of this pool caused activation of ruthenium red-inhibitable RyR1 Ca2+ leaks suggesting that SERCA1 pump formation of outward Ca2+ gradients is an important aspect of Ca2+ flux control channel opening and closing.	Ruthenium Red	60-73	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	118-124
32421358-6	2020	Inhibition of transient receptor potential vanilloid 1 (TRPV1) and TRPV1 and ankyrin 1 cation channels (TRPA1) with ruthenium red eliminated the difference.	Ruthenium Red	116-129	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-54
32652086-8	2020	Olanzapine treatment also altered the mRNA expression of hypothalamic appetite-regulating and nutrient-sensing factors, inflammatory genes and TRPV1/TRPV3, which were reversed with ruthenium red and capsazepine treatment.	Ruthenium Red	181-194	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	143-148
32652086-8	2020	Olanzapine treatment also altered the mRNA expression of hypothalamic appetite-regulating and nutrient-sensing factors, inflammatory genes and TRPV1/TRPV3, which were reversed with ruthenium red and capsazepine treatment.	Ruthenium Red	181-194	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	149-154
32706268-4	2020	In the present work, we demonstrated in an ex vivo diaphragmatic tissue rat model that diaphragmatic lymphatics express transient receptor potential channels of the vanilloid 4 subfamily (TRPV4) and that their blockade by both the nonselective antagonist Ruthenium Red and the selective antagonist HC-067047 abolished the response of lymphatics to temperature changes.	Ruthenium Red	255-268	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	188-193
32421358-6	2020	Inhibition of transient receptor potential vanilloid 1 (TRPV1) and TRPV1 and ankyrin 1 cation channels (TRPA1) with ruthenium red eliminated the difference.	Ruthenium Red	116-129	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	104-109
32421358-6	2020	Inhibition of transient receptor potential vanilloid 1 (TRPV1) and TRPV1 and ankyrin 1 cation channels (TRPA1) with ruthenium red eliminated the difference.	Ruthenium Red	116-129	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-61
32421358-6	2020	Inhibition of transient receptor potential vanilloid 1 (TRPV1) and TRPV1 and ankyrin 1 cation channels (TRPA1) with ruthenium red eliminated the difference.	Ruthenium Red	116-129	ankyrin 1	Rattus norvegicus	77-86
31778738-6	2020	Vanilloid transient potential (TRPV) channel inhibitor Ruthenium Red, but not a voltage-dependent calcium channel (VDCC) inhibitor nifedipine, efficiently stunted Ca2+ entry, and comparable abrogation was reproduced in cells treated with TRPV4-selective inhibitor RN-1734 or transfected with TRPV4-specific siRNA.	Ruthenium Red	55-68	transient receptor potential cation channel subfamily V member 4	Homo sapiens	238-243
32149229-4	2020	In contrast, addition of capsaicin to TRPV1-expressing HEK293 cells containing an optimum amount of a TRPV1 antagonist (ruthenium red), resulted in no detectable magnetic or fluorescent signals.	Ruthenium Red	120-133	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
32692797-3	2020	Rats were treated with different doses of MCU blocker ruthenium red (RuR), administered 5 min before ischemia or reperfusion.	Ruthenium Red	54-67	mitochondrial calcium uniporter	Rattus norvegicus	42-45
32692797-3	2020	Rats were treated with different doses of MCU blocker ruthenium red (RuR), administered 5 min before ischemia or reperfusion.	Ruthenium Red	69-72	mitochondrial calcium uniporter	Rattus norvegicus	42-45
31778738-6	2020	Vanilloid transient potential (TRPV) channel inhibitor Ruthenium Red, but not a voltage-dependent calcium channel (VDCC) inhibitor nifedipine, efficiently stunted Ca2+ entry, and comparable abrogation was reproduced in cells treated with TRPV4-selective inhibitor RN-1734 or transfected with TRPV4-specific siRNA.	Ruthenium Red	55-68	transient receptor potential cation channel subfamily V member 4	Homo sapiens	292-297
31727906-9	2019	Yoda1 evoked Ca2+ entry was inhibited by Yoda1 antagonist Dooku1 as well as other Piezo1 inhibitors gadolinium and ruthenium red, and not mimicked by 2e.	Ruthenium Red	115-128	piezo-type mechanosensitive ion channel component 1	Mus musculus	82-88
31664854-9	2020	There is little evidence, however, that TRPA1, TRPV1, TRPC3, TRPC6, or other ruthenium red-sensitive TRP channels are required for PAR1/Gq-PLCbeta3-mediated membrane depolarization and action potential discharge in bronchopulmonary nodose C-fibers in the mouse.	Ruthenium Red	77-90	phospholipase C, beta 3	Mus musculus	139-147
31542963-11	2020	The effects of H2S were significantly antagonized by administration of glibenclamide as KATP channel blocker, Nomega-nitro-l-arginine, as eNOS inhibitor, or ruthenium red, as transient receptor potential vanilloid 1 (TRPV1) antagonist.	Ruthenium Red	157-170	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	175-215
31719194-9	2019	Finally, macrophages generate TRPV2-like heat-induced inward currents upon oxidation and exhibit reduced phagocytosis when exposed to the TRP channel inhibitor ruthenium red (RR) or to DTT.	Ruthenium Red	160-173	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	30-35
31719194-9	2019	Finally, macrophages generate TRPV2-like heat-induced inward currents upon oxidation and exhibit reduced phagocytosis when exposed to the TRP channel inhibitor ruthenium red (RR) or to DTT.	Ruthenium Red	175-177	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	30-35
30761248-8	2019	In addition, TRPV4 was activated by hypotonic solutions (220 m Osm), and this effect was abolished by ruthenium red.	Ruthenium Red	102-115	transient receptor potential cation channel subfamily V member 4	Homo sapiens	13-18
31680945-12	2019	However, the protective effect could be ameliorated by ruthenium red (an MCU inhibitor) and abrogated by spermine (an MCU activator) in vitro.	Ruthenium Red	55-68	mitochondrial calcium uniporter	Rattus norvegicus	73-76
31365302-4	2019	This procedure was repeated before and after injecting the TRPV1 blockers - capsazepine (100mug100muL-1), ruthenium red (100mug100muL-1) or IRTX (1mug100muL-1).	Ruthenium Red	106-119	mitochondrial E3 ubiquitin protein ligase 1	Rattus norvegicus	130-135
30756474-3	2019	Under physiological conditions, MCU can be inhibited by ruthenium red (RR) and activated by spermine (Sper).	Ruthenium Red	56-69	mitochondrial calcium uniporter	Mus musculus	32-35
30756474-3	2019	Under physiological conditions, MCU can be inhibited by ruthenium red (RR) and activated by spermine (Sper).	Ruthenium Red	71-73	mitochondrial calcium uniporter	Mus musculus	32-35
30756474-7	2019	Blockage of MCU by RR prevented Ca2+ and iron accumulation, abated the level of oxidative stress, improved the energy supply, stabilized mitochondria, reduced DNA damage and decreased apoptosis both in vivo and in vitro.	Ruthenium Red	19-21	mitochondrial calcium uniporter	Mus musculus	12-15
30933994-14	2019	Furthermore, the analyses of purified recombinant EFCAB2 by Stains-all, ruthenium red staining, and by applying in vitro autoradiography assay showed that the physiological function of this protein is Ca2+ binding.	Ruthenium Red	72-85	EF-hand calcium binding domain 2	Mus musculus	50-56
30649920-8	2019	In contrast, probenecid, a TRPV2 activator, induced an increase in [Ca2+]c in MIN6 cells, which was attenuated by ruthenium red.	Ruthenium Red	114-127	transient receptor potential cation channel, subfamily V, member 2	Mus musculus	27-32
31415758-5	2019	This effect was abolished by treating cells with mechano-gated channel inhibitors, such as gadolinium, transient receptor potential (TRP) family inhibitor, ruthenium red, and with pharmacological and small interfering RNA-mediated TRPV1 inhibition.	Ruthenium Red	156-169	transient receptor potential cation channel subfamily V member 1	Homo sapiens	231-236
30826858-5	2019	Unexpectedly, CaSR response (high Ca2+-elicited cytosolic [Ca2+] elevation) was unaffected by edelfosine or U73122 but strongly suppressed by SK&F 96365, ruthenium red, and 2-aminoethoxydiphenyl borate (2-APB), suggesting involvement of TRPV and TRPC channels but not Gq-phospholipase C. Acute application of NPS2143, a negative allosteric modulator of CaSR, suppressed CaSR response.	Ruthenium Red	158-171	calcium-sensing receptor	Mus musculus	14-18
30707395-7	2019	Ruthenium red (RR) staining of the seeds showed defective mucilage of tlp2-1 mutant after vigorous shaking compared to wild type (WT).	Ruthenium Red	0-13	tubby like protein 2	Arabidopsis thaliana	70-74
30707395-7	2019	Ruthenium red (RR) staining of the seeds showed defective mucilage of tlp2-1 mutant after vigorous shaking compared to wild type (WT).	Ruthenium Red	15-17	tubby like protein 2	Arabidopsis thaliana	70-74
30717379-6	2019	Ruthenium red (a non-selective antagonist of TRP channels, including TRPV3), when administered intravenously at a dose of 0.1 mg/kg, attenuated the self-grooming behavior induced by either ambient warmth or epidermal camphor.	Ruthenium Red	0-13	transient receptor potential cation channel, subfamily V, member 3	Rattus norvegicus	69-74
31685769-2	2019	TRPV4 antagonists ruthenium red and HC-067047 significantly blocked increased urinary volume after intragastric administration of water and 4alpha-PDD-induced diuresis.	Ruthenium Red	18-31	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
30299584-5	2018	TRPV3 expression was also increased in Ang II-induced cardiomyocyte hypertrophy in vitro, which was remarkably increased by carvacrol (a nonselective TRPV channel agonist), and reduced by ruthenium red (a nonselective TRPV channel antagonist).	Ruthenium Red	188-201	transient receptor potential cation channel, subfamily V, member 3	Rattus norvegicus	0-5
29803339-6	2018	Seven-week administration of MCU inhibitor ruthenium red improved cardiac function and mitigated its pathological change.	Ruthenium Red	43-56	mitochondrial calcium uniporter	Homo sapiens	29-32
30454562-3	2018	We unexpectedly find that MICU1 suppresses inhibition of MCU by ruthenium red/Ru360, which bind to MCU"s DIME motif, the selectivity filter.	Ruthenium Red	64-77	mitochondrial calcium uptake 1	Homo sapiens	26-31
30454562-3	2018	We unexpectedly find that MICU1 suppresses inhibition of MCU by ruthenium red/Ru360, which bind to MCU"s DIME motif, the selectivity filter.	Ruthenium Red	64-77	mitochondrial calcium uniporter	Homo sapiens	57-60
30454562-3	2018	We unexpectedly find that MICU1 suppresses inhibition of MCU by ruthenium red/Ru360, which bind to MCU"s DIME motif, the selectivity filter.	Ruthenium Red	64-77	mitochondrial calcium uniporter	Homo sapiens	99-102
30226565-5	2018	Suppression of TRPV1 activity by treatment with the TRPV1 antagonists capsazepine and ruthenium red significantly reduced UV-induced GSDMC expression, whereas direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased GSDMC expression.	Ruthenium Red	86-99	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
30251695-11	2018	Treatment of ALR-shRNA-cells with Ruthenium Red (RuR), a specific inhibitor of mitochondrial calcium uniporter (MCU), significantly suppressed mitochondrial Ca2+ influx, HSC migration, mitochondrial fusion and ATP production.	Ruthenium Red	34-47	growth factor, augmenter of liver regeneration	Mus musculus	13-16
30226565-5	2018	Suppression of TRPV1 activity by treatment with the TRPV1 antagonists capsazepine and ruthenium red significantly reduced UV-induced GSDMC expression, whereas direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased GSDMC expression.	Ruthenium Red	86-99	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
30226565-5	2018	Suppression of TRPV1 activity by treatment with the TRPV1 antagonists capsazepine and ruthenium red significantly reduced UV-induced GSDMC expression, whereas direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased GSDMC expression.	Ruthenium Red	86-99	gasdermin C	Homo sapiens	133-138
30226565-5	2018	Suppression of TRPV1 activity by treatment with the TRPV1 antagonists capsazepine and ruthenium red significantly reduced UV-induced GSDMC expression, whereas direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased GSDMC expression.	Ruthenium Red	86-99	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
30226565-5	2018	Suppression of TRPV1 activity by treatment with the TRPV1 antagonists capsazepine and ruthenium red significantly reduced UV-induced GSDMC expression, whereas direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased GSDMC expression.	Ruthenium Red	86-99	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
30226565-5	2018	Suppression of TRPV1 activity by treatment with the TRPV1 antagonists capsazepine and ruthenium red significantly reduced UV-induced GSDMC expression, whereas direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased GSDMC expression.	Ruthenium Red	86-99	gasdermin C	Homo sapiens	227-232
28597712-6	2018	Subsequently, we used transient middle cerebral artery occlusion and found that ruthenium red, a blocker of CALHM1, or the lack of CALHM1, substantially attenuated the motor symptoms and reduced significantly the infarct volume.	Ruthenium Red	80-93	calcium homeostasis modulator 1	Mus musculus	108-114
30235802-8	2018	These Ca2+ transients could be blocked both by ruthenium red, an unspecific Ca2+ channel blocker, and tranilast (TRA), an antagonist of TRPV2, and were also abolished when extracellular Ca2+ was removed.	Ruthenium Red	47-60	carbonic anhydrase 2	Homo sapiens	6-9
30235802-8	2018	These Ca2+ transients could be blocked both by ruthenium red, an unspecific Ca2+ channel blocker, and tranilast (TRA), an antagonist of TRPV2, and were also abolished when extracellular Ca2+ was removed.	Ruthenium Red	47-60	carbonic anhydrase 2	Homo sapiens	76-79
30235802-8	2018	These Ca2+ transients could be blocked both by ruthenium red, an unspecific Ca2+ channel blocker, and tranilast (TRA), an antagonist of TRPV2, and were also abolished when extracellular Ca2+ was removed.	Ruthenium Red	47-60	carbonic anhydrase 2	Homo sapiens	76-79
29621761-15	2018	Ruthenium red (a TRPV5 inhibitor) can relieve progression of joint destruction in vivo which promoted us to demonstrate the effect of TRPV5 in OA.	Ruthenium Red	0-13	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	17-22
29446495-6	2018	Using correlative phenotyping of structural and biochemical characteristics, unique features of the cobl2 extruded mucilage are revealed, including: "unraveled" ray morphology, loss of primary cell wall "pyramidal" organization, reduced Ruthenium red staining intensity of the adherent mucilage layer, and increased levels of the monosaccharides arabinose and galactose.	Ruthenium Red	237-250	COBRA-like protein 2 precursor	Arabidopsis thaliana	100-105
29307826-7	2018	These single channel currents are sensitive to the specific MCU inhibitor Ruthenium Red.	Ruthenium Red	74-87	mitochondrial calcium uniporter	Homo sapiens	60-63
29664963-3	2018	Mechanical stretch increased intracellular Ca2+ influx and induced release of pro-inflammatory cytokines in lung epithelial cells that was partially blocked by about 30% with the selective TRPV4 inhibitor GSK2193874, but nearly completely blocked with the pan-calcium channel blocker ruthenium red, suggesting the involvement of more than one calcium channel in the response to mechanical stress.	Ruthenium Red	284-297	transient receptor potential cation channel subfamily V member 4	Homo sapiens	189-194
29428723-6	2018	Additionally, the Piezo1 antagonists, gadolinium and ruthenium red, but not GsMTx4, effectively blocks Yoda1-induced Akt activation.	Ruthenium Red	53-66	piezo type mechanosensitive ion channel component 1	Homo sapiens	18-24
29428723-6	2018	Additionally, the Piezo1 antagonists, gadolinium and ruthenium red, but not GsMTx4, effectively blocks Yoda1-induced Akt activation.	Ruthenium Red	53-66	AKT serine/threonine kinase 1	Homo sapiens	117-120
29621761-15	2018	Ruthenium red (a TRPV5 inhibitor) can relieve progression of joint destruction in vivo which promoted us to demonstrate the effect of TRPV5 in OA.	Ruthenium Red	0-13	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	134-139
28947137-6	2017	However, co-treatment of HINT2 overexpressing BxPC-3 cells with ruthenium red partially inhibited HINT2-induced apoptosis, which was associated with a reduction in DeltaPsim and an increase in intracellular ROS and mitochondrial Ca2+.	Ruthenium Red	64-77	histidine triad nucleotide binding protein 2	Homo sapiens	25-30
28947137-6	2017	However, co-treatment of HINT2 overexpressing BxPC-3 cells with ruthenium red partially inhibited HINT2-induced apoptosis, which was associated with a reduction in DeltaPsim and an increase in intracellular ROS and mitochondrial Ca2+.	Ruthenium Red	64-77	histidine triad nucleotide binding protein 2	Homo sapiens	98-103
28878377-6	2017	Treating vitrified bovine oocytes with 1 muM ruthenium red (RR) significantly inhibited the Ca2+ flux from the cytoplasm into mitochondria; maintained normal mCa2+ levels, mitochondrial membrane potential, and ATP content; and inhibited apoptosis.	Ruthenium Red	45-58	carbonic anhydrase 2	Mus musculus	92-95
29204122-6	2017	Furthermore, LETM1 depletion selectively decreased Na+/Ca2+ exchange mediated by NCLX, as observed in the presence of ruthenium red, a blocker of the Mitochondrial Ca2+ Uniporter (MCU).	Ruthenium Red	118-131	leucine zipper and EF-hand containing transmembrane protein 1	Homo sapiens	13-18
29204122-6	2017	Furthermore, LETM1 depletion selectively decreased Na+/Ca2+ exchange mediated by NCLX, as observed in the presence of ruthenium red, a blocker of the Mitochondrial Ca2+ Uniporter (MCU).	Ruthenium Red	118-131	solute carrier family 8 member B1	Homo sapiens	81-85
28722259-6	2017	In TRPV1-transfected HEK293 cells, Orn and Lys (10 mM) evoked Ca2+ influx, which was blocked by ruthenium red, a TRP channel antagonist.	Ruthenium Red	96-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	3-8
28782267-5	2017	LFEx and 4,5-di-O-CQA (EC50  = 69.34 +- 1.12 muM) activated TRPV1, and these activations were significantly inhibited by ruthenium red, a general blocker of TRP channels, and capsazepine, a specific antagonist of TRPV1.	Ruthenium Red	121-134	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-65
28782267-5	2017	LFEx and 4,5-di-O-CQA (EC50  = 69.34 +- 1.12 muM) activated TRPV1, and these activations were significantly inhibited by ruthenium red, a general blocker of TRP channels, and capsazepine, a specific antagonist of TRPV1.	Ruthenium Red	121-134	transient receptor potential cation channel subfamily V member 1	Homo sapiens	213-218
28878377-6	2017	Treating vitrified bovine oocytes with 1 muM ruthenium red (RR) significantly inhibited the Ca2+ flux from the cytoplasm into mitochondria; maintained normal mCa2+ levels, mitochondrial membrane potential, and ATP content; and inhibited apoptosis.	Ruthenium Red	45-58	carbonic anhydrase 2	Mus musculus	158-162
28878377-6	2017	Treating vitrified bovine oocytes with 1 muM ruthenium red (RR) significantly inhibited the Ca2+ flux from the cytoplasm into mitochondria; maintained normal mCa2+ levels, mitochondrial membrane potential, and ATP content; and inhibited apoptosis.	Ruthenium Red	60-62	carbonic anhydrase 2	Mus musculus	92-95
28878377-6	2017	Treating vitrified bovine oocytes with 1 muM ruthenium red (RR) significantly inhibited the Ca2+ flux from the cytoplasm into mitochondria; maintained normal mCa2+ levels, mitochondrial membrane potential, and ATP content; and inhibited apoptosis.	Ruthenium Red	60-62	carbonic anhydrase 2	Mus musculus	158-162
28181698-6	2017	Interestingly, ruthenium red and Ru360, both inhibitors of the mitochondrial Ca2+ uniporter (MCU), blocked palmitic acid-induced mitochondrial Ca2+ elevation, cytochrome c release from mitochondria to cytosol, and apoptosis.	Ruthenium Red	15-28	mitochondrial calcium uniporter	Mus musculus	63-91
28181698-6	2017	Interestingly, ruthenium red and Ru360, both inhibitors of the mitochondrial Ca2+ uniporter (MCU), blocked palmitic acid-induced mitochondrial Ca2+ elevation, cytochrome c release from mitochondria to cytosol, and apoptosis.	Ruthenium Red	15-28	mitochondrial calcium uniporter	Mus musculus	93-96
28254749-7	2017	Brefeldin A, a vesicular transport inhibitor, and ruthenium red, a nonselective CALHM1 channel blocker, also significantly inhibited stretch-mediated ATP release from urothelial cells.	Ruthenium Red	50-63	calcium homeostasis modulator 1	Homo sapiens	80-86
28456852-12	2017	Expression of P-selectin increased in endothelial cells following administration of a TRPV4 agonist, which was ameliorated by simultaneous addition of RR.	Ruthenium Red	151-153	selectin P	Rattus norvegicus	14-24
28456852-12	2017	Expression of P-selectin increased in endothelial cells following administration of a TRPV4 agonist, which was ameliorated by simultaneous addition of RR.	Ruthenium Red	151-153	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	86-91
28388364-7	2017	RI currents were pharmacologically blocked by ruthenium red, a compound known to block Piezo2, and were also reduced by small interfering RNA-mediated Piezo2 knockdown.	Ruthenium Red	46-59	piezo-type mechanosensitive ion channel component 2	Mus musculus	87-93
28388364-7	2017	RI currents were pharmacologically blocked by ruthenium red, a compound known to block Piezo2, and were also reduced by small interfering RNA-mediated Piezo2 knockdown.	Ruthenium Red	46-59	piezo-type mechanosensitive ion channel component 2	Mus musculus	151-157
28573491-7	2017	Ruthenium red (RU-2), a general transient receptor potential (TRP) inhibitor, reduced currents induced by ATP.	Ruthenium Red	0-13	doublecortin domain containing 2	Homo sapiens	15-19
27743934-11	2017	Moreover, application of the transient receptor potential (TRP) channel antagonist ruthenium red (RR) attenuated the hAmylin-induced increase in Ca2+.	Ruthenium Red	98-100	islet amyloid polypeptide	Homo sapiens	117-124
28274876-7	2017	These effects were almost abolished by calcium-free buffer and significantly inhibited by gadolinium (III) chloride (a mechanosensitive Ca2+ channel blocker) and ruthenium red (a transient receptor potential vanilloid 4 (TRPV4) blocker).	Ruthenium Red	162-175	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	179-219
28274876-7	2017	These effects were almost abolished by calcium-free buffer and significantly inhibited by gadolinium (III) chloride (a mechanosensitive Ca2+ channel blocker) and ruthenium red (a transient receptor potential vanilloid 4 (TRPV4) blocker).	Ruthenium Red	162-175	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	221-226
27743934-11	2017	Moreover, application of the transient receptor potential (TRP) channel antagonist ruthenium red (RR) attenuated the hAmylin-induced increase in Ca2+.	Ruthenium Red	83-96	islet amyloid polypeptide	Homo sapiens	117-124
28535500-10	2017	RESULTS: We constructed a monosodium iodoacetate (MIA) -induced rat OA model and found that ruthenium red (TRPV5 inhibitor) slowed the progression of joint destruction.	Ruthenium Red	92-105	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	107-112
26979077-6	2017	Oral treatment with selective agonists for CaSR (R-568) or TRPA1 (allyl isothiocyanate (AITC)) suppressed food intake in mice, and the agonist"s effects were suppressed by pretreatment with corresponding antagonists NPS-2143 or ruthenium red (RR), respectively.	Ruthenium Red	228-241	calcium-sensing receptor	Mus musculus	43-47
26979077-6	2017	Oral treatment with selective agonists for CaSR (R-568) or TRPA1 (allyl isothiocyanate (AITC)) suppressed food intake in mice, and the agonist"s effects were suppressed by pretreatment with corresponding antagonists NPS-2143 or ruthenium red (RR), respectively.	Ruthenium Red	228-241	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	59-64
26979077-6	2017	Oral treatment with selective agonists for CaSR (R-568) or TRPA1 (allyl isothiocyanate (AITC)) suppressed food intake in mice, and the agonist"s effects were suppressed by pretreatment with corresponding antagonists NPS-2143 or ruthenium red (RR), respectively.	Ruthenium Red	243-245	calcium-sensing receptor	Mus musculus	43-47
26979077-6	2017	Oral treatment with selective agonists for CaSR (R-568) or TRPA1 (allyl isothiocyanate (AITC)) suppressed food intake in mice, and the agonist"s effects were suppressed by pretreatment with corresponding antagonists NPS-2143 or ruthenium red (RR), respectively.	Ruthenium Red	243-245	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	59-64
27722942-8	2016	Control experiments with non TRPV1 channel expressing HEK cells as well as experiments with the TRPV1 channel blocker ruthenium red validated the specificity of the observed impedance decrease.	Ruthenium Red	118-131	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-101
27262216-9	2016	It may be concluded that ruthenium red, a ryanodine receptor antagonist and pioglitazone, a PPAR-gamma agonist may be considered as potent pharmacological agent for the management of PaD induced endothelial dysfunction and subsequent vascular dementia.	Ruthenium Red	25-38	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	92-102
27366753-4	2016	Moreover, TRPV4 was upregulated by 4alpha-PDD and SB203580 and downregulated by RR and anisomycin.	Ruthenium Red	80-82	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	10-15
27129242-7	2016	The heteromer was inhibited by extracellular acidification and by spadin similarly to TREK-1, and its ruthenium red sensitivity was intermediate between TREK-1 and TREK-2 homodimers.	Ruthenium Red	102-115	potassium channel, two pore domain subfamily K, member 2 S homeolog	Xenopus laevis	153-159
26891254-8	2016	This stretch-evoked 5-HT overflow was inhibited by transient receptor potential A1 (TRPA1) agonist, 30 muM ruthenium red in both circular and longitudinal muscle preparations.	Ruthenium Red	107-120	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	51-82
26891254-8	2016	This stretch-evoked 5-HT overflow was inhibited by transient receptor potential A1 (TRPA1) agonist, 30 muM ruthenium red in both circular and longitudinal muscle preparations.	Ruthenium Red	107-120	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	84-89
26634999-8	2016	Ruthenium Red treatment results in the loss of CML38 signal in cytosolic granules, suggesting that calcium is necessary for stress granule association.	Ruthenium Red	0-13	calmodulin-like 38	Arabidopsis thaliana	47-52
27610031-7	2016	NAC- and cysteine-induced [Ca(2+)]i increase was effectively inhibited by calcium channel inhibitors SKF96365 (10 microM) and ruthenium red (20 microM).	Ruthenium Red	126-139	X-linked Kx blood group	Homo sapiens	0-3
27610031-9	2016	Our results show that NAC and cysteine induce [Ca(2+)]i increase through Ca(2+) influx in human neutrophils via SKF96365- and ruthenium red-dependent way.	Ruthenium Red	126-139	X-linked Kx blood group	Homo sapiens	22-25
27367668-7	2016	Under non-stimulated conditions, hypotonicity-induced trafficking of AQP5 to the APM was inhibited by ruthenium red and La(3+), suggesting the involvement of extracellular Ca(2+) entry.	Ruthenium Red	102-115	aquaporin 5	Rattus norvegicus	69-73
26865051-4	2016	Probenecid, an activator of TRPV2, induced an increase in intracellular Ca(2+) (Ca(2+) i ), an effect that may be attenuated or abolished by the TRPV2 blocker ruthenium red.	Ruthenium Red	159-172	transient receptor potential cation channel subfamily V member 2	Homo sapiens	28-33
26865051-4	2016	Probenecid, an activator of TRPV2, induced an increase in intracellular Ca(2+) (Ca(2+) i ), an effect that may be attenuated or abolished by the TRPV2 blocker ruthenium red.	Ruthenium Red	159-172	transient receptor potential cation channel subfamily V member 2	Homo sapiens	145-150
26760212-6	2016	The H(+)-gated [Ca(2+)]i elevation is mediated by channels with characteristics of TRPA1, being inhibited by ruthenium red, isopentenyl pyrophosphate, HC-030031, A967079 or TRPA1 knockout.	Ruthenium Red	109-122	transient receptor potential cation channel subfamily A member 1	Homo sapiens	83-88
26413835-4	2016	Using calcium imaging, we show that AQP-mediated fast swelling kinetics also significantly increases the amplitude of calcium transients inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium.	Ruthenium Red	165-178	transient receptor potential cation channel subfamily V member 4	Homo sapiens	202-242
26413835-4	2016	Using calcium imaging, we show that AQP-mediated fast swelling kinetics also significantly increases the amplitude of calcium transients inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium.	Ruthenium Red	165-178	transient receptor potential cation channel subfamily V member 4	Homo sapiens	244-249
25399955-6	2016	Treatment with TRPV4 antagonists (HC-067047 and ruthenium red) dose-dependently reduced brain infarction at 24 h post-MCAO.	Ruthenium Red	48-61	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	15-20