PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29197540-2	2018	Compounds 3 and 4 are structurally characterized as intact lanostane-type triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is a 24-methylene-lanostane.	triterpenoids	74-87	RNA polymerase III subunit K	Homo sapiens	137-141
30504678-2	2018	In the present study, we further investigated the biological activities of three pentacyclic triterpenoids closely related to ursolic acid on the interleukin 1alpha-induced expression and intracellular trafficking of ICAM-1.	triterpenoids	93-106	interleukin 1 alpha	Homo sapiens	146-164
30504678-2	2018	In the present study, we further investigated the biological activities of three pentacyclic triterpenoids closely related to ursolic acid on the interleukin 1alpha-induced expression and intracellular trafficking of ICAM-1.	triterpenoids	93-106	intercellular adhesion molecule 1	Homo sapiens	217-223
29077044-4	2017	We aimed to investigate whether bioactive triterpenoids modulate the KLK5 protease.	triterpenoids	42-55	kallikrein related peptidase 5	Homo sapiens	69-73
29042257-9	2017	HRLC-MS and GC-MS helped identify the presence of gymnemic acid (GA), triterpenoids and steroids in EL which could be the reason for PK interaction of CYP1A2 and CYP2C9.	triterpenoids	70-83	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	151-157
29077044-10	2017	Our study reveals that triterpenoids, such as ursolic acid and tumulosic acid, modulate the KLK5 protease activity and cathelicidin peptide production.	triterpenoids	23-36	kallikrein related peptidase 5	Homo sapiens	92-96
29077044-5	2017	Nineteen triterpenoids occurring in medicinal crude drugs were evaluated using an enzymatic assay to measure the anti-KLK5 activity.	triterpenoids	9-22	kallikrein related peptidase 5	Homo sapiens	118-122
28366661-0	2017	Synthetic triterpenoids inhibit GSK3beta activity and localization and affect focal adhesions and cell migration.	triterpenoids	10-23	glycogen synthase kinase 3 beta	Homo sapiens	32-40
28946703-0	2017	Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation.	triterpenoids	8-21	interleukin 6	Homo sapiens	54-58
28946703-0	2017	Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation.	triterpenoids	8-21	signal transducer and activator of transcription 3	Homo sapiens	67-72
28735730-9	2017	In addition, a total of 21 lupane-type triterpenoids structurally-related to impressic acid were isolated from the same plant materials and their suppressive activities against MMP-13 expression were also examined.	triterpenoids	39-52	collagenase 3	Oryctolagus cuniculus	177-183
28506899-8	2017	Moreover, a HepG2 cell model treated with CCl4 (0.35%) was used to screen the protective activities of 29 AC triterpenoids.	triterpenoids	109-122	C-C motif chemokine ligand 4	Homo sapiens	42-46
28506899-13	2017	At 20muM, 16 of 29 triterpenoids showed significant protective activities, increasing HepG2 cell viability from 46% of the CCl4 group to >90%.	triterpenoids	19-32	C-C motif chemokine ligand 4	Homo sapiens	123-127
28851867-3	2017	Triterpenoids are a class of small molecules with potent immunomodulatory activity linked to activation of Nrf2 target genes, and can also suppress the manifestations of experimental autoimmune encephalomyelitis (EAE).	triterpenoids	0-13	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
28754329-0	2017	Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids.	triterpenoids	116-129	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	14-41
28754329-0	2017	Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids.	triterpenoids	116-129	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	43-46
28754329-4	2017	In this study, we investigated the inhibitory effects of various polyphenols and triterpenoids on the UGT-mediated GA 3-O-glucuronidation.	triterpenoids	81-94	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	102-105
28766112-5	2017	The molecular simulations revealed that oleanolic acid and ursolic acid interact with amino acid residues within the binding pocket of human salivary alpha-amylase, among which the side chain of Arg195 and Asp 197 was supposed to be important in imparting the inhibitory activity of triterpenoids.	triterpenoids	283-296	amylase alpha 1A	Homo sapiens	141-163
28366661-8	2017	Therefore, the triterpenoids may affect cell migration via a mechanism that targets and alters the activity and localization of GSK3beta.	triterpenoids	15-28	glycogen synthase kinase 3 beta	Homo sapiens	128-136
28366661-2	2017	We have shown that triterpenoids inhibit cell migration in part by interfering with Arp2/3-dependent branched actin polymerization in lamellipodia (To et al., 2010).	triterpenoids	19-32	actin related protein 2	Homo sapiens	84-88
28366661-4	2017	Furthermore, triterpenoids were observed to inhibit GSK3beta activity and increase cellular focal adhesion size.	triterpenoids	13-26	glycogen synthase kinase 3 beta	Homo sapiens	52-60
28713276-0	2017	Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1.	triterpenoids	48-61	carboxylesterase 1	Homo sapiens	111-129
28713276-3	2017	To this end, a series of natural triterpenoids were collected and their inhibitory effects against human carboxylesterases (hCEs) were assayed using D-Luciferin methyl ester (DME) and 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate (DDAB) as specific optical substrate for hCE1, and hCE2, respectively.	triterpenoids	33-46	carboxylesterase 1	Homo sapiens	105-122
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	triterpenoids	43-56	carboxylesterase 1	Homo sapiens	146-150
28507119-0	2017	Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids.	triterpenoids	81-94	cation channel sperm associated 1	Homo sapiens	40-47
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	triterpenoids	43-56	carboxylesterase 2	Homo sapiens	186-190
28713276-6	2017	The inhibitory effects of these derivatives on hCEs were assayed and the structure-activity relationships of tested triterpenoids as hCE1 inhibitors were carefully investigated.	triterpenoids	116-129	carboxylesterase 1	Homo sapiens	133-137
28713276-9	2017	3D-QSAR analysis of all tested triterpenoids including OA and UA derivatives provide new insights into the fine relationships linking between the inhibitory effects on hCE1 and the steric-electrostatic properties of triterpenoids.	triterpenoids	31-44	carboxylesterase 1	Homo sapiens	168-172
28713276-9	2017	3D-QSAR analysis of all tested triterpenoids including OA and UA derivatives provide new insights into the fine relationships linking between the inhibitory effects on hCE1 and the steric-electrostatic properties of triterpenoids.	triterpenoids	216-229	carboxylesterase 1	Homo sapiens	168-172
28126414-7	2017	Furthermore, the structural information and inhibitory capacities of all reported hCEs inhibitors including fatty acids, flavonoids, tanshinones and triterpenoids have been systematically summarized.	triterpenoids	149-162	cat eye syndrome chromosome region	Homo sapiens	82-86
28445411-7	2017	To the best of our knowledge, this is the first report on semi-synthetic pentacyclic triterpenoids with FXR-modulatory activities.	triterpenoids	85-98	nuclear receptor subfamily 1 group H member 4	Homo sapiens	104-107
28322779-0	2017	Semisynthetic oleanane triterpenoids inhibit migration and invasion of human breast cancer cells through downregulated expression of the ITGB1/PTK2/PXN pathway.	triterpenoids	23-36	integrin subunit beta 1	Homo sapiens	137-142
28322779-0	2017	Semisynthetic oleanane triterpenoids inhibit migration and invasion of human breast cancer cells through downregulated expression of the ITGB1/PTK2/PXN pathway.	triterpenoids	23-36	protein tyrosine kinase 2	Homo sapiens	143-147
28322779-0	2017	Semisynthetic oleanane triterpenoids inhibit migration and invasion of human breast cancer cells through downregulated expression of the ITGB1/PTK2/PXN pathway.	triterpenoids	23-36	paxillin	Homo sapiens	148-151
29050217-0	2017	Triterpenoids from Aglaia abbreviata exert cytotoxicity and multidrug resistant reversal effect in MCF-7/ADM cells via reactive oxygen species induction and P-glycoprotein inhibition.	triterpenoids	0-13	ATP binding cassette subfamily B member 1	Homo sapiens	157-171
28929690-9	2016	AR triterpenoids extracts had the ability of activation for PPARalpha, PPARbeta and PPARgamma.	triterpenoids	3-16	peroxisome proliferator activated receptor alpha	Homo sapiens	60-69
28134508-4	2017	Through screening a small molecule library, we have identified a class of synthetic triterpenoids that efficiently inhibit ghrelin acylation by the human isoform of GOAT (hGOAT).	triterpenoids	84-97	appetite-regulating hormone	Capra hircus	123-130
28867736-3	2017	Among these triterpenoids, compound 4, which showed the most potent inhibitory activity, effectively down-regulated LPS-induced protein expression of inducible nitric oxide synthase (iNOS) in RAW264.7 cells and in HT-29 cells.	triterpenoids	12-25	nitric oxide synthase 2, inducible	Mus musculus	150-181
28024463-0	2017	In silico Evidence for Binding of Pentacyclic Triterpenoids to Keap1-Nrf2 Protein-Protein Binding Site.	triterpenoids	46-59	kelch like ECH associated protein 1	Homo sapiens	63-68
28024463-0	2017	In silico Evidence for Binding of Pentacyclic Triterpenoids to Keap1-Nrf2 Protein-Protein Binding Site.	triterpenoids	46-59	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
28024463-3	2017	Naturally occurring pentacyclic triterpenoids (PTs) and their synthetic derivatives are projected as activators of Nrf2 signalling.	triterpenoids	32-45	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
28929690-9	2016	AR triterpenoids extracts had the ability of activation for PPARalpha, PPARbeta and PPARgamma.	triterpenoids	3-16	peroxisome proliferator activated receptor gamma	Homo sapiens	84-93
28929690-10	2016	The results suggested that triterpenoids extracts from AR were PPARalpha, PPARbeta and PPARgamma agonists.	triterpenoids	27-40	peroxisome proliferator activated receptor alpha	Homo sapiens	63-72
27989132-5	2016	Many dietary phytochemicals with cancer chemopreventive properties, such as polyphenols, isothiocyanates, and triterpenoids, exert antioxidant and anti-inflammatory functions by activating the Nrf2 pathway.	triterpenoids	110-123	NFE2 like bZIP transcription factor 2	Homo sapiens	193-197
27591010-0	2016	Triterpenoids from Momordica balsamina: Reversal of ABCB1-mediated multidrug resistance.	triterpenoids	0-13	ATP binding cassette subfamily B member 1	Homo sapiens	52-57
27591010-1	2016	The ability as P-glycoprotein (P-gp, ABCB1) modulators of thirty (1-30) triterpenoids of the cucurbitane-type was evaluated on human L5178 mouse T-lymphoma cell line transfected with the human MDR1 gene, through the rhodamine-123 exclusion assay.	triterpenoids	72-85	ATP binding cassette subfamily B member 1	Homo sapiens	15-29
27591010-1	2016	The ability as P-glycoprotein (P-gp, ABCB1) modulators of thirty (1-30) triterpenoids of the cucurbitane-type was evaluated on human L5178 mouse T-lymphoma cell line transfected with the human MDR1 gene, through the rhodamine-123 exclusion assay.	triterpenoids	72-85	ATP binding cassette subfamily B member 1	Homo sapiens	31-35
27591010-1	2016	The ability as P-glycoprotein (P-gp, ABCB1) modulators of thirty (1-30) triterpenoids of the cucurbitane-type was evaluated on human L5178 mouse T-lymphoma cell line transfected with the human MDR1 gene, through the rhodamine-123 exclusion assay.	triterpenoids	72-85	ATP binding cassette subfamily B member 1	Homo sapiens	37-42
28929690-10	2016	The results suggested that triterpenoids extracts from AR were PPARalpha, PPARbeta and PPARgamma agonists.	triterpenoids	27-40	peroxisome proliferator activated receptor delta	Homo sapiens	74-82
28929690-10	2016	The results suggested that triterpenoids extracts from AR were PPARalpha, PPARbeta and PPARgamma agonists.	triterpenoids	27-40	peroxisome proliferator activated receptor gamma	Homo sapiens	87-96
28929690-9	2016	AR triterpenoids extracts had the ability of activation for PPARalpha, PPARbeta and PPARgamma.	triterpenoids	3-16	peroxisome proliferator activated receptor delta	Homo sapiens	71-79
27333990-4	2016	In an attempt to develop novel anti-KRAS mutant chemotherapeutics, we isolated three novel triterpenoids from Amoora rohituka stem and their chemical structures were characterized by extensive 1H-NMR, 13C-NMR, Mass, IR spectroscopic studies and chemical transformations.	triterpenoids	91-104	KRAS proto-oncogene, GTPase	Homo sapiens	36-40
27242339-2	2016	RS9 is categorized as a triterpenoid, and well-known triterpenoids such as RTA 402 (bardoxolone methyl) and RTA 408 have been tested in clinical trials.	triterpenoids	53-66	MAS related GPR family member F	Homo sapiens	75-78
27242339-5	2016	All the above triterpenoids increased the level of an Nrf2-targeted gene, NADPH:quinone oxidoreductase-1, in normal human epidermal keratinocytes.	triterpenoids	14-27	NFE2 like bZIP transcription factor 2	Homo sapiens	54-58
27242339-5	2016	All the above triterpenoids increased the level of an Nrf2-targeted gene, NADPH:quinone oxidoreductase-1, in normal human epidermal keratinocytes.	triterpenoids	14-27	2,4-dienoyl-CoA reductase 1	Homo sapiens	74-79
26006769-0	2016	Therapeutic effects of nanogel containing triterpenoids isolated from Ganoderma lucidum (GLT) using therapeutic ultrasound (TUS) for frostbite in rats.	triterpenoids	42-55	solute carrier family 1 member 2	Rattus norvegicus	89-92
26006769-1	2016	OBJECTIVE: The aim of this study was to evaluate the effect of therapeutic ultrasound (TUS) on dermal delivery and therapeutic effect for frostbite of nanogel containing triterpenoids isolated from Ganoderma lucidum (GLT).	triterpenoids	170-183	solute carrier family 1 member 2	Rattus norvegicus	217-220
27449295-10	2016	Investigation of other pentacyclic triterpenoids may aid in the development of novel SENP1 inhibitor drugs.	triterpenoids	35-48	SUMO specific peptidase 1	Homo sapiens	85-90
27032192-3	2016	All lanostane triterpenoids (1-16) possesses a carboxy group at C-20 position and their strength of antiproliferative activity was affected by the presence or absence of a hydroxy group at C-15 position and at the side chain.	triterpenoids	14-27	placenta associated 8	Homo sapiens	189-193
27359376-0	2016	Novel triterpenoids isolated from raisins exert potent antiproliferative activities by targeting mitochondrial and Ras/Raf/ERK signaling in human breast cancer cells.	triterpenoids	6-19	zinc fingers and homeoboxes 2	Homo sapiens	119-122
27359376-0	2016	Novel triterpenoids isolated from raisins exert potent antiproliferative activities by targeting mitochondrial and Ras/Raf/ERK signaling in human breast cancer cells.	triterpenoids	6-19	EPH receptor B2	Homo sapiens	123-126
27287417-0	2016	Inhibitory effects of pentacyclic triterpenoids from Astilbe rivularis on TGFBIp-induced inflammatory responses in vitro and in vivo.	triterpenoids	34-47	transforming growth factor beta induced	Homo sapiens	74-80
26908173-1	2016	Semisynthetic triterpenoids such as bardoxolone methyl (methyl-2-cyano 3,12-dioxooleano-1,9-dien-28-oate; CDDO-Me) (4) are potent inducers of antioxidant and anti-inflammatory signaling pathways, including those regulated by the transcription factor Nrf2.	triterpenoids	14-27	NFE2 like bZIP transcription factor 2	Rattus norvegicus	250-254
26845717-9	2016	Furthermore, the triterpenoids increased the expression of cyclin-B1, cyclin-D1 and cleaved caspase-3, as determined by immunofluorescence, indicating an important role of apoptosis in cell death induced by these compounds.	triterpenoids	17-30	cyclin B1	Homo sapiens	59-68
24963753-0	2016	Nanogel for dermal application of the triterpenoids isolated from Ganoderma lucidum (GLT) for frostbite treatment.	triterpenoids	38-51	solute carrier family 1 member 2	Rattus norvegicus	85-88
26996014-0	2016	Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids.	triterpenoids	99-112	sucrase-isomaltase	Homo sapiens	14-31
26845717-9	2016	Furthermore, the triterpenoids increased the expression of cyclin-B1, cyclin-D1 and cleaved caspase-3, as determined by immunofluorescence, indicating an important role of apoptosis in cell death induced by these compounds.	triterpenoids	17-30	cyclin D1	Homo sapiens	70-79
26425784-0	2015	Protostane Triterpenoids from the Rhizome of Alisma orientale Exhibit Inhibitory Effects on Human Carboxylesterase 2.	triterpenoids	11-24	carboxylesterase 2	Homo sapiens	98-116
26314956-0	2015	Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells.	triterpenoids	30-43	lon peptidase 1, mitochondrial	Homo sapiens	14-26
26474287-0	2015	Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.	triterpenoids	80-93	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	21-26
25428559-0	2015	Spectroscopic analysis on structure-affinity relationship in the interactions of different oleanane-type triterpenoids with bovine serum albumin.	triterpenoids	105-118	albumin	Homo sapiens	131-144
25939751-0	2015	Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.	triterpenoids	35-48	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
25939751-5	2015	Although the triterpenoids and DMF both activated the Nrf2 pathway, CDDO-Im and CDDO-Me were markedly more potent than DMF.	triterpenoids	13-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
25690285-3	2015	Three triterpenoids isolated from the root bark of the plant, koetjapic (1), 3-oxoolean-12-en-30-oic (2), and betulinic (3) acids, exhibited significant concentration-dependent inhibitory effects on PGE2 production with IC50 values of 1.05, 1.54, and 2.59 muM, respectively, as compared with the positive control, indomethacin (IC50 = 0.45 muM).	triterpenoids	6-19	latexin	Homo sapiens	256-259
25970614-1	2015	Cucurbitacins, the natural triterpenoids possessing many biological activities, have been reported to suppress the mTORC1/p70S6K pathway and to induce autophagy.	triterpenoids	27-40	CREB regulated transcription coactivator 1	Mus musculus	115-121
25970614-1	2015	Cucurbitacins, the natural triterpenoids possessing many biological activities, have been reported to suppress the mTORC1/p70S6K pathway and to induce autophagy.	triterpenoids	27-40	ribosomal protein S6 kinase B1	Homo sapiens	122-128
25938234-0	2015	Pentacyclic Triterpenoids Inhibit IKKbeta Mediated Activation of NF-kappaB Pathway: In Silico and In Vitro Evidences.	triterpenoids	12-25	inhibitor of kappaB kinase beta	Mus musculus	34-41
25938234-0	2015	Pentacyclic Triterpenoids Inhibit IKKbeta Mediated Activation of NF-kappaB Pathway: In Silico and In Vitro Evidences.	triterpenoids	12-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	65-74
25683606-13	2015	This suggests that Nrf2-activating drugs including triterpenoids could be a therapeutic strategy for retinal neuroprotection.	triterpenoids	51-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
25511620-5	2015	This review article is focused on triterpenoids that activate Nrf2, and their potential for reducing oxidative stress in SCD as an approach to prevent organ dysfunction associated with this disease.	triterpenoids	34-47	NFE2 like bZIP transcription factor 2	Homo sapiens	62-66
25690285-3	2015	Three triterpenoids isolated from the root bark of the plant, koetjapic (1), 3-oxoolean-12-en-30-oic (2), and betulinic (3) acids, exhibited significant concentration-dependent inhibitory effects on PGE2 production with IC50 values of 1.05, 1.54, and 2.59 muM, respectively, as compared with the positive control, indomethacin (IC50 = 0.45 muM).	triterpenoids	6-19	latexin	Homo sapiens	340-343
25536195-2	2014	Synthetic triterpenoids, including CDDO-Me, act as anti-inflammatory and antioxidant modulators primarily by inducing the transcription factor Nrf2 to activate downstream genes containing antioxidant response elements (AREs).	triterpenoids	10-23	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
24715223-1	2014	INTRODUCTION: Synthetic triterpenoids inhibit IL-17 and improve autoimmune disease in mice.	triterpenoids	24-37	interleukin 17A	Mus musculus	46-51
25238076-0	2014	Triterpenoids as novel natural inhibitors of human cathepsin L.	triterpenoids	0-13	cathepsin L	Homo sapiens	51-62
25088972-5	2014	Among the triterpenoids isolated, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid (7), 9 and 10 showed high potent inhibitory activity toward the proliferation of HepG2 cells, which the IC50 values were lower than 5 muM.	triterpenoids	10-23	latexin	Homo sapiens	222-225
25238076-2	2014	Using a bioactivity-guided fractionation, a series of triterpenoids was identified as a new class of competitive inhibitors towards cathepsin L with affinity values in micromolar range.	triterpenoids	54-67	cathepsin L	Homo sapiens	132-143
23795939-1	2013	A search for inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) from Walsura cochinchinensis yielded 10 new limonoids, cochinchinoids A-J (1-10), and two new triterpenoids, 3-epimesendanin S (11) and cochinchinoid K (12).	triterpenoids	178-191	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	71-82
24783956-8	2014	NRF2 inducers such as phytochemical isothyocyanates and synthetic triterpenoids, have been discovered and used in model systems of oxidant-induced lung diseases, and data suggest a potential for clinical interventions.	triterpenoids	66-79	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
24548018-2	2014	In the current contribution, our central goal was to integratively dissect the biointeraction of two typical triterpenoids, ursolic acid and oleanolic acid, by the most fundamental macromolecule bovine serum albumin (BSA) by employing molecular modeling, steady state and time-resolved fluorescence, and circular dichroism spectra at the molecular scale.	triterpenoids	109-122	albumin	Homo sapiens	202-215
24457265-1	2014	The C-3, C-17 and C-22 congeners of pentacyclic triterpenoids reduced lantadene A (3), B (4) and 22beta-hydroxyoleanolic acid (5) were synthesized and were tested in vitro for their NF-kappaB and IKKbeta inhibitory potencies and cytotoxicity against A549 lung cancer cells.	triterpenoids	48-61	complement C3	Homo sapiens	4-13
24457265-1	2014	The C-3, C-17 and C-22 congeners of pentacyclic triterpenoids reduced lantadene A (3), B (4) and 22beta-hydroxyoleanolic acid (5) were synthesized and were tested in vitro for their NF-kappaB and IKKbeta inhibitory potencies and cytotoxicity against A549 lung cancer cells.	triterpenoids	48-61	nuclear factor kappa B subunit 1	Homo sapiens	182-191
24457265-1	2014	The C-3, C-17 and C-22 congeners of pentacyclic triterpenoids reduced lantadene A (3), B (4) and 22beta-hydroxyoleanolic acid (5) were synthesized and were tested in vitro for their NF-kappaB and IKKbeta inhibitory potencies and cytotoxicity against A549 lung cancer cells.	triterpenoids	48-61	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	196-203
24486487-2	2014	Several synthetic oleanolic triterpenoids including dihydro-CDDO-trifluoroethyl amide (dh404) appear to be potent activators of Nrf2 and exhibit chemopreventive promises in multiple disease models.	triterpenoids	28-41	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
24533814-3	2014	However, most known inducers (e.g., triterpenoids, isothiocyanates and sulfoxythiocarbamates) that activate the ARE system through electrophilic attacks on the cysteine sulfhydryl group of Keap1 also disrupt theKeap1-Nrf2 interaction.	triterpenoids	36-49	kelch like ECH associated protein 1	Homo sapiens	189-194
24533814-3	2014	However, most known inducers (e.g., triterpenoids, isothiocyanates and sulfoxythiocarbamates) that activate the ARE system through electrophilic attacks on the cysteine sulfhydryl group of Keap1 also disrupt theKeap1-Nrf2 interaction.	triterpenoids	36-49	NFE2 like bZIP transcription factor 2	Homo sapiens	217-221
24697659-4	2014	Among the isolates, three pentacyclic triterpenoids, ursolic acid (1), asiatic acid (3) and terminolic acid (6), together with one tannin casuarinin (17), were found to significantly decrease interleukin-8 (IL-8) production in human colon cancer cells.	triterpenoids	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	192-205
24697659-4	2014	Among the isolates, three pentacyclic triterpenoids, ursolic acid (1), asiatic acid (3) and terminolic acid (6), together with one tannin casuarinin (17), were found to significantly decrease interleukin-8 (IL-8) production in human colon cancer cells.	triterpenoids	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
24204647-6	2013	To our knowledge, this is the first report to show that G.lucidum triterpenoids could suppress cell migration and adhesion through FAK-SRC-paxillin signaling pathway.	triterpenoids	66-79	protein tyrosine kinase 2	Homo sapiens	131-134
24204647-6	2013	To our knowledge, this is the first report to show that G.lucidum triterpenoids could suppress cell migration and adhesion through FAK-SRC-paxillin signaling pathway.	triterpenoids	66-79	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	135-138
25027934-1	2014	The new series of pentacyclic triterpenoids reduced lantadene A (3), B (4), and 22beta-hydroxy-3-oxo-olean-12-en-28-oic acid (5) analogs were synthesized and tested in vitro for their NF-kappaB and IKKbeta inhibitory potencies and cytotoxicity against A549 lung cancer cells.	triterpenoids	30-43	nuclear factor kappa B subunit 1	Homo sapiens	184-193
25027934-1	2014	The new series of pentacyclic triterpenoids reduced lantadene A (3), B (4), and 22beta-hydroxy-3-oxo-olean-12-en-28-oic acid (5) analogs were synthesized and tested in vitro for their NF-kappaB and IKKbeta inhibitory potencies and cytotoxicity against A549 lung cancer cells.	triterpenoids	30-43	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	198-205
24869765-0	2014	Dammarane-type triterpenoids as 11beta-HSD1 inhibitors from Homonoia riparia.	triterpenoids	15-28	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	32-43
24869765-1	2014	An exploration for 11beta-HSD1 inhibitors from Homonoia riparia returned eight new dammarane-type triterpenoids, horipenoids A-H (1-8), and a known oleanane-type triterpenoid (9).	triterpenoids	98-111	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	19-30
24837432-3	2014	Synthetic triterpenoids are a class of small molecules that suppress COX-2 as well as inflammatory cytokine signaling.	triterpenoids	10-23	prostaglandin-endoperoxide synthase 2	Mus musculus	69-74
24879289-0	2014	Discovery of triterpenoids as reversible inhibitors of alpha/beta-hydrolase domain containing 12 (ABHD12).	triterpenoids	13-26	abhydrolase domain containing 12, lysophospholipase	Homo sapiens	98-104
24879289-9	2014	Although the triterpenoids typically may have multiple protein targets, we witnessed unprecedented selectivity for ABHD12 among the metabolic serine hydrolases, as activity-based protein profiling of mouse brain membrane proteome indicated that the representative ABHD12 inhibitors did not inhibit other serine hydrolases, nor did they target cannabinoid receptors.	triterpenoids	13-26	abhydrolase domain containing 12	Mus musculus	264-270
24606795-41	2014	Other strategies include the triggering of Nrf2/antioxidant response element (ARE) pathway by triterpenoids (derivatives of oleanolic acid) or by Bacopa monniera, the enhancement of ATP production by carnitine and -lipoic acid.	triterpenoids	94-107	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47
24659938-2	2014	Low nanomolar concentrations of triterpenoids inhibit the induction of inflammatory cytokines, and these drugs are potent activators of the Nrf2 cytoprotective pathway.	triterpenoids	32-45	NFE2 like bZIP transcription factor 2	Homo sapiens	140-144
24659938-5	2014	In an experimental model of lung cancer, the triterpenoids activated the Nrf2 pathway, as seen by induction of the cytoprotective enzyme NQO1, and reduced the toxicity of carboplatin and paclitaxel.	triterpenoids	45-58	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
24659938-5	2014	In an experimental model of lung cancer, the triterpenoids activated the Nrf2 pathway, as seen by induction of the cytoprotective enzyme NQO1, and reduced the toxicity of carboplatin and paclitaxel.	triterpenoids	45-58	NAD(P)H quinone dehydrogenase 1	Homo sapiens	137-141
23244591-4	2013	While it has been well-established that synthetic oleanane triterpenoids pharmacologically activate Nrf2, their effects on bile flow and hepatic cytoprotective capacity have not been fully explored.	triterpenoids	59-72	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-104
23480293-0	2013	Oxidation of Fe(II) leads to increased C-2 methylation of pentacyclic triterpenoids in the anoxygenic phototrophic bacterium Rhodopseudomonas palustris strain TIE-1.	triterpenoids	70-83	complement C2	Homo sapiens	39-42
23480293-8	2013	The presence of C-2 methylated pentacyclic triterpenoids has commonly been used as a biosignature for the interpretation of paleoenvironments.	triterpenoids	43-56	complement C2	Homo sapiens	16-19
24009841-0	2012	Targeting nrf2-mediated gene transcription by triterpenoids and their derivatives.	triterpenoids	46-59	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
23614029-10	2013	A significant decrease of CD31-positive tumor blood vessels was observed after treatment with solubilized triterpenoids and different mistletoe extracts.	triterpenoids	106-119	platelet/endothelial cell adhesion molecule 1	Mus musculus	26-30
23717159-0	2013	Oleanane-triterpenoids from Panax stipuleanatus inhibit NF-kappaB.	triterpenoids	9-22	nuclear factor kappa B subunit 1	Homo sapiens	56-65
22583404-7	2012	Triterpenoids also activate or deactive nuclear receptors and G-protein coupled receptors, and these pathways contribute to their antitumorigenic activity and may also play a role in targeting Sp1, Sp3 and Sp4 which are highly overexpressed in multiple cancers and appear to be important for maintaining the cancer phenotype.	triterpenoids	0-13	Sp3 transcription factor	Homo sapiens	198-201
22583404-7	2012	Triterpenoids also activate or deactive nuclear receptors and G-protein coupled receptors, and these pathways contribute to their antitumorigenic activity and may also play a role in targeting Sp1, Sp3 and Sp4 which are highly overexpressed in multiple cancers and appear to be important for maintaining the cancer phenotype.	triterpenoids	0-13	Sp4 transcription factor	Homo sapiens	206-209
23581983-8	2013	The most effective Keap1-Nrf2 activators are synthetic oleanane triterpenoids.	triterpenoids	64-77	kelch like ECH associated protein 1	Homo sapiens	19-24
23581983-8	2013	The most effective Keap1-Nrf2 activators are synthetic oleanane triterpenoids.	triterpenoids	64-77	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
24009841-4	2012	Activation of Nrf2 by triterpenoids induces the expression of phase 2 detoxifying and antioxidant enzymes such as NAD(P)H quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) - proteins which can protect cells or tissues against various toxic metabolites.	triterpenoids	22-35	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
24009841-4	2012	Activation of Nrf2 by triterpenoids induces the expression of phase 2 detoxifying and antioxidant enzymes such as NAD(P)H quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) - proteins which can protect cells or tissues against various toxic metabolites.	triterpenoids	22-35	NAD(P)H quinone dehydrogenase 1	Homo sapiens	114-146
24009841-4	2012	Activation of Nrf2 by triterpenoids induces the expression of phase 2 detoxifying and antioxidant enzymes such as NAD(P)H quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) - proteins which can protect cells or tissues against various toxic metabolites.	triterpenoids	22-35	NAD(P)H quinone dehydrogenase 1	Homo sapiens	148-152
24009841-4	2012	Activation of Nrf2 by triterpenoids induces the expression of phase 2 detoxifying and antioxidant enzymes such as NAD(P)H quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) - proteins which can protect cells or tissues against various toxic metabolites.	triterpenoids	22-35	heme oxygenase 1	Homo sapiens	158-174
22812017-0	2012	[Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4].	triterpenoids	1-14	chemokine (C-C motif) ligand 4	Mus musculus	87-91
23045680-5	2012	Here, we report that Nrf2 activation by the synthetic triterpenoids, bardoxolone methyl (BARD) and 2-cyano-3,12-dioxooleana-1,9 (11)-dien-28-oic acid-ethyl amide, protects colonic epithelial cells against IR-induced damage, in part, by enhancing signaling of the DNA damage response.	triterpenoids	54-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
23045680-10	2012	These results demonstrate that Nrf2 activation by synthetic triterpenoids is a promising candidate target to protect the gastrointestinal tract against acute IR in vitro and in vivo.	triterpenoids	60-73	nuclear factor, erythroid derived 2, like 2	Mus musculus	31-35
22659375-3	2012	Docking results suggested that both the triterpenoids (1 and 2) showed immune modulatory and anti-inflammatory activity due to high binding affinity to human receptors viz., NF-kappaB p52 (-50.549 kcal/mol), tumor necrosis factor (TNF-alpha) (-47.632 kcal/mol), nuclear factor NF-Kappa-B P50 (-16.798 kcal/mol) and cyclooxygenase-2 (-55.244 kcal/mol).	triterpenoids	40-53	tumor necrosis factor	Homo sapiens	208-229
22659375-3	2012	Docking results suggested that both the triterpenoids (1 and 2) showed immune modulatory and anti-inflammatory activity due to high binding affinity to human receptors viz., NF-kappaB p52 (-50.549 kcal/mol), tumor necrosis factor (TNF-alpha) (-47.632 kcal/mol), nuclear factor NF-Kappa-B P50 (-16.798 kcal/mol) and cyclooxygenase-2 (-55.244 kcal/mol).	triterpenoids	40-53	tumor necrosis factor	Homo sapiens	231-240
22659375-3	2012	Docking results suggested that both the triterpenoids (1 and 2) showed immune modulatory and anti-inflammatory activity due to high binding affinity to human receptors viz., NF-kappaB p52 (-50.549 kcal/mol), tumor necrosis factor (TNF-alpha) (-47.632 kcal/mol), nuclear factor NF-Kappa-B P50 (-16.798 kcal/mol) and cyclooxygenase-2 (-55.244 kcal/mol).	triterpenoids	40-53	nuclear factor kappa B subunit 1	Homo sapiens	277-291
22659375-3	2012	Docking results suggested that both the triterpenoids (1 and 2) showed immune modulatory and anti-inflammatory activity due to high binding affinity to human receptors viz., NF-kappaB p52 (-50.549 kcal/mol), tumor necrosis factor (TNF-alpha) (-47.632 kcal/mol), nuclear factor NF-Kappa-B P50 (-16.798 kcal/mol) and cyclooxygenase-2 (-55.244 kcal/mol).	triterpenoids	40-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	315-331
23252274-6	2012	RESULTS: The substrate was transformed to two new hydroxyl substituted triterpenoids, with a yield of 21.15%; The products displayed anti-proliferative effect against PC3 and DU145 cells with IC50 values of 14.5 micromol/L and 27.8 micromol/L, respectively.	triterpenoids	71-84	chromobox 8	Homo sapiens	167-170
21933912-7	2012	In BRCA1-deficient cell lines, the triterpenoids directly interacted with ErbB2, decreased constitutive phosphorylation of ErbB2, inhibited proliferation, and induced G(0)-G(1) arrest.	triterpenoids	35-48	erb-b2 receptor tyrosine kinase 2	Mus musculus	74-79
21933912-7	2012	In BRCA1-deficient cell lines, the triterpenoids directly interacted with ErbB2, decreased constitutive phosphorylation of ErbB2, inhibited proliferation, and induced G(0)-G(1) arrest.	triterpenoids	35-48	erb-b2 receptor tyrosine kinase 2	Mus musculus	123-128
21880714-0	2011	Ligand-receptor interaction between triterpenoids and the 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells.	triterpenoids	36-49	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	102-112
21651437-1	2011	With the exception of polysaccharides and triterpenes/triterpenoids compounds, fungal immunomodulatory protein (FIP), a small molecule protein, is also an important bioactive component with immune regulating activity.	triterpenoids	54-67	upstream transcription factor 2, c-fos interacting	Homo sapiens	112-115
21880714-2	2011	Ligand fitting of five different triterpenoids to 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) was analyzed with a molecular modeling method, and glycyrrhetinic acid (GA) was the best-fitted triterpenoid to the ligand binding site in 11betaHSD2.	triterpenoids	33-46	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	94-104
21880714-8	2011	To the best of our knowledge, this is the first report on in silico prediction of the toxic effects of triterpenoids on tumor cells by 11betaHSD2 inhibition.	triterpenoids	103-116	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	135-145
22355716-2	2011	Here we demonstrate the dual capacity of triterpenoids to simultaneously repress production of IL-17 and other pro-inflammatory mediators while exerting neuroprotective effects directly through Nrf2-dependent induction of anti-oxidant genes.	triterpenoids	41-54	interleukin 17A	Mus musculus	95-100
21893415-0	2011	Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.	triterpenoids	41-54	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	10-14
21193311-4	2011	A search for estramustine phosphate analogs led to identification of two triterpenoids, enoxolone, and celastrol, having Shp2 PTP inhibitor activity.	triterpenoids	73-86	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	121-125
21193311-4	2011	A search for estramustine phosphate analogs led to identification of two triterpenoids, enoxolone, and celastrol, having Shp2 PTP inhibitor activity.	triterpenoids	73-86	protein tyrosine phosphatase receptor type U	Homo sapiens	126-129
21193311-5	2011	With the previously reported PTP1B inhibitor trodusquemine, our study reveals steroids and triterpenoids with negatively charged phosphate, carboxylate, or sulfonate groups as novel pharmacophores of selective PTP inhibitors.	triterpenoids	91-104	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	29-34
21193311-5	2011	With the previously reported PTP1B inhibitor trodusquemine, our study reveals steroids and triterpenoids with negatively charged phosphate, carboxylate, or sulfonate groups as novel pharmacophores of selective PTP inhibitors.	triterpenoids	91-104	protein tyrosine phosphatase receptor type U	Homo sapiens	29-32
21503999-1	2011	A rapid and stable method consisting of high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry was established for the identification and differentiation of common diastereoisomeric ursane-type triterpenoids at the C-3 position.	triterpenoids	240-253	complement C3	Homo sapiens	261-264
21503999-4	2011	Energy-resolved mass spectrometric experiments were carried out to support the differentiation of these diastereoisomeric triterpenoids at the C-3 position.	triterpenoids	122-135	complement C3	Homo sapiens	143-146
21503999-5	2011	Using this method, a total of nine ursane-type triterpenoids from a plant crude extract, including four pairs of epimers at the C-3 position, were identified and distinguished rapidly.	triterpenoids	47-60	complement C3	Homo sapiens	128-131
22355716-2	2011	Here we demonstrate the dual capacity of triterpenoids to simultaneously repress production of IL-17 and other pro-inflammatory mediators while exerting neuroprotective effects directly through Nrf2-dependent induction of anti-oxidant genes.	triterpenoids	41-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	194-198
20959520-8	2010	In cell lines developed from the KPC mice, the triterpenoids directly interact with both signal transducer and activator of transcription 3 and IkappaB kinase (IKK) to decrease constitutive interleukin-6 secretion, inhibit constitutive signal transducer and activator of transcription 3 phosphorylation, and block the degradation of IkappaBalpha when challenged with tumor necrosis factor alpha.	triterpenoids	47-60	signal transducer and activator of transcription 3	Mus musculus	89-139
20959520-8	2010	In cell lines developed from the KPC mice, the triterpenoids directly interact with both signal transducer and activator of transcription 3 and IkappaB kinase (IKK) to decrease constitutive interleukin-6 secretion, inhibit constitutive signal transducer and activator of transcription 3 phosphorylation, and block the degradation of IkappaBalpha when challenged with tumor necrosis factor alpha.	triterpenoids	47-60	interleukin 6	Mus musculus	190-203
20959520-8	2010	In cell lines developed from the KPC mice, the triterpenoids directly interact with both signal transducer and activator of transcription 3 and IkappaB kinase (IKK) to decrease constitutive interleukin-6 secretion, inhibit constitutive signal transducer and activator of transcription 3 phosphorylation, and block the degradation of IkappaBalpha when challenged with tumor necrosis factor alpha.	triterpenoids	47-60	tumor necrosis factor	Mus musculus	367-394
20959520-8	2010	In cell lines developed from the KPC mice, the triterpenoids directly interact with both signal transducer and activator of transcription 3 and IkappaB kinase (IKK) to decrease constitutive interleukin-6 secretion, inhibit constitutive signal transducer and activator of transcription 3 phosphorylation, and block the degradation of IkappaBalpha when challenged with tumor necrosis factor alpha.	triterpenoids	47-60	signal transducer and activator of transcription 3	Mus musculus	236-286
20959520-8	2010	In cell lines developed from the KPC mice, the triterpenoids directly interact with both signal transducer and activator of transcription 3 and IkappaB kinase (IKK) to decrease constitutive interleukin-6 secretion, inhibit constitutive signal transducer and activator of transcription 3 phosphorylation, and block the degradation of IkappaBalpha when challenged with tumor necrosis factor alpha.	triterpenoids	47-60	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	333-345
20670429-4	2010	Studies have indicated that triterpenoids could act as PPAR agonists and GA is therefore postulated to restore LPL expression in the insulin resistant state.	triterpenoids	28-41	peroxisome proliferator activated receptor alpha	Rattus norvegicus	55-59
20566646-2	2010	Here, we used mass spectrometric and protein array approaches and uncovered that triterpenoids associate with proteins of the actin cytoskeleton, including actin-related protein 3 (Arp3).	triterpenoids	81-94	actin related protein 3	Rattus norvegicus	156-179
20566646-2	2010	Here, we used mass spectrometric and protein array approaches and uncovered that triterpenoids associate with proteins of the actin cytoskeleton, including actin-related protein 3 (Arp3).	triterpenoids	81-94	actin related protein 3	Rattus norvegicus	181-185
20566646-6	2010	Taken together, our data suggest that synthetic triterpenoids target Arp3 and branched actin polymerization to inhibit cell migration.	triterpenoids	48-61	actin related protein 3	Rattus norvegicus	69-73
20846448-0	2010	In vivo induction of phase II detoxifying enzymes, glutathione transferase and quinone reductase by citrus triterpenoids.	triterpenoids	107-120	crystallin, zeta	Mus musculus	79-96
20171069-2	2010	As measured by HPLC, Cyracos contains significant amounts of rosmarinic acid and the triterpenoids oleanolic acid and ursolic acid, which inhibit gamma-aminobutyric acid transaminase (GABA-T) activity and increase GABA levels in the brain (Awad et al., 2007; Awad et al., 2009).	triterpenoids	85-98	4-aminobutyrate aminotransferase	Mus musculus	146-182
20171069-2	2010	As measured by HPLC, Cyracos contains significant amounts of rosmarinic acid and the triterpenoids oleanolic acid and ursolic acid, which inhibit gamma-aminobutyric acid transaminase (GABA-T) activity and increase GABA levels in the brain (Awad et al., 2007; Awad et al., 2009).	triterpenoids	85-98	4-aminobutyrate aminotransferase	Mus musculus	184-190
19732782-7	2010	Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids.	triterpenoids	331-344	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
19732782-7	2010	Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids.	triterpenoids	331-344	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
19911773-1	2010	We describe here the biological screening of a collection of natural occurring triterpenoids against the G protein-coupled receptor TGR5, known to be activated by bile acids and which mediates some important cell functions.	triterpenoids	79-92	G protein-coupled bile acid receptor 1	Homo sapiens	132-136
20018812-7	2010	Docking data indicated that these tetracyclic triterpenoids form hydrogen bonds within the phosphatidylinositol binding pocket of the Akt pleckstrin homology domain.	triterpenoids	46-59	AKT serine/threonine kinase 1	Homo sapiens	134-137
20392997-0	2010	Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells.	triterpenoids	10-23	AKT serine/threonine kinase 1	Homo sapiens	83-86
20392997-0	2010	Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells.	triterpenoids	10-23	mechanistic target of rapamycin kinase	Homo sapiens	88-92
20392997-0	2010	Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells.	triterpenoids	10-23	nuclear factor kappa B subunit 1	Homo sapiens	97-108
19494206-0	2009	Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.	triterpenoids	10-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
19494206-0	2009	Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.	triterpenoids	10-23	thymoma viral proto-oncogene 1	Mus musculus	93-96
19494206-0	2009	Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.	triterpenoids	10-23	phosphatase and tensin homolog	Mus musculus	151-155
19846941-0	2009	Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein (ABCB1) by flow cytometry and real-time fluorometry.	triterpenoids	31-44	ATP binding cassette subfamily B member 1	Homo sapiens	73-87
19846941-0	2009	Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein (ABCB1) by flow cytometry and real-time fluorometry.	triterpenoids	31-44	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	89-94
19360320-7	2009	(Ume) fruit (Ume extract), an abundant source of triterpenoids, strongly inhibited HMGB1 release from lipopolysaccharide (LPS)-stimulated macrophage-like RAW264.7 cells.	triterpenoids	49-62	high mobility group box 1	Mus musculus	83-88
19534474-0	2009	Sipholane triterpenoids: chemistry, reversal of ABCB1/P-glycoprotein-mediated multidrug resistance, and pharmacophore modeling.	triterpenoids	10-23	ATP binding cassette subfamily B member 1	Homo sapiens	48-53
19534474-0	2009	Sipholane triterpenoids: chemistry, reversal of ABCB1/P-glycoprotein-mediated multidrug resistance, and pharmacophore modeling.	triterpenoids	10-23	ATP binding cassette subfamily B member 1	Homo sapiens	54-68
19911563-4	2009	Ursane triterpenoids 8-10 exhibited moderate cytotoxicity against PC3 cells with IC50 values ranging from 10.1 to 39.7 microM.	triterpenoids	7-20	chromobox 8	Homo sapiens	66-69
19100343-7	2009	KHBJ-9B and 3 combined triterpenoids potently inhibited the release of proteoglycan and type II collagen in a dose dependent manner without cytotoxicity in IL-1beta-treated human cartilage explants culture, whereas its single major compounds (betulin, pimaradienoic acid and betulinic acid) and COX-2 inhibitor (NS398) showed little inhibition even at high concentrations.	triterpenoids	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	295-300
18822345-4	2009	In this study, we present the synthesis and the biological evaluation of ursan or oleanan type triterpenoids which may act as selective 11beta-HSD1 inhibitors in liver as well as in peripheral tissues, like adipocytes and muscle cells.	triterpenoids	95-108	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	136-147
19100343-8	2009	KHBJ-9B and the combination of 3 triterpenoids markedly inhibited the level of IL-1beta and TNF-alpha, and down-regulated the level of aggrecanases, ADAMTS-4, ADAMTS-5, MMP-1 and MMP-13, and up-regulated TIMP-3 in human cartilage explants culture.	triterpenoids	33-46	interleukin 1 beta	Homo sapiens	79-87
19100343-8	2009	KHBJ-9B and the combination of 3 triterpenoids markedly inhibited the level of IL-1beta and TNF-alpha, and down-regulated the level of aggrecanases, ADAMTS-4, ADAMTS-5, MMP-1 and MMP-13, and up-regulated TIMP-3 in human cartilage explants culture.	triterpenoids	33-46	tumor necrosis factor	Homo sapiens	92-101
19100343-8	2009	KHBJ-9B and the combination of 3 triterpenoids markedly inhibited the level of IL-1beta and TNF-alpha, and down-regulated the level of aggrecanases, ADAMTS-4, ADAMTS-5, MMP-1 and MMP-13, and up-regulated TIMP-3 in human cartilage explants culture.	triterpenoids	33-46	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	149-157
19100343-8	2009	KHBJ-9B and the combination of 3 triterpenoids markedly inhibited the level of IL-1beta and TNF-alpha, and down-regulated the level of aggrecanases, ADAMTS-4, ADAMTS-5, MMP-1 and MMP-13, and up-regulated TIMP-3 in human cartilage explants culture.	triterpenoids	33-46	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	159-167
19100343-8	2009	KHBJ-9B and the combination of 3 triterpenoids markedly inhibited the level of IL-1beta and TNF-alpha, and down-regulated the level of aggrecanases, ADAMTS-4, ADAMTS-5, MMP-1 and MMP-13, and up-regulated TIMP-3 in human cartilage explants culture.	triterpenoids	33-46	matrix metallopeptidase 1	Homo sapiens	169-174
19100343-8	2009	KHBJ-9B and the combination of 3 triterpenoids markedly inhibited the level of IL-1beta and TNF-alpha, and down-regulated the level of aggrecanases, ADAMTS-4, ADAMTS-5, MMP-1 and MMP-13, and up-regulated TIMP-3 in human cartilage explants culture.	triterpenoids	33-46	matrix metallopeptidase 13	Homo sapiens	179-185
19100343-8	2009	KHBJ-9B and the combination of 3 triterpenoids markedly inhibited the level of IL-1beta and TNF-alpha, and down-regulated the level of aggrecanases, ADAMTS-4, ADAMTS-5, MMP-1 and MMP-13, and up-regulated TIMP-3 in human cartilage explants culture.	triterpenoids	33-46	TIMP metallopeptidase inhibitor 3	Homo sapiens	204-210
19213570-11	2009	Moreover, from immunofluorescence experiments we observed that treatment with these triterpenoids prevents nuclear factor NF-kappaB translocation into the nucleus and thereby the activation of downstream pathways.	triterpenoids	84-97	nuclear factor kappa B subunit 1	Homo sapiens	122-131
19063958-8	2009	Docking data showed that triterpenoids were the most active phytochemicals and the oleanane-type triterpenoids presented better LTB-binding abilities than other types of triterpenoids.	triterpenoids	97-110	lymphotoxin B	Mus musculus	128-131
19063958-8	2009	Docking data showed that triterpenoids were the most active phytochemicals and the oleanane-type triterpenoids presented better LTB-binding abilities than other types of triterpenoids.	triterpenoids	97-110	lymphotoxin B	Mus musculus	128-131
18608528-0	2008	Immunomodulatory activity of synthetic triterpenoids: inhibition of lymphocyte proliferation, cell-mediated cytotoxicity, and cytokine gene expression through suppression of NF-kappaB.	triterpenoids	39-52	nuclear factor kappa B subunit 1	Homo sapiens	174-183
18384989-4	2008	This paper aimed to investigate the anti-inflammatory and analgesic activities of the MTF extract and two main limonoid-type triterpenoids isolated from MTF.	triterpenoids	125-138	melanotransferrin	Mus musculus	153-156
18838692-3	2008	We recently found that the anti-inflammatory potencies (suppression of iNOS and COX-2 expression) of a series of triterpenoids with Michael reaction centers were closely correlated with the potencies of these agents to induce the phase 2 response.	triterpenoids	113-126	nitric oxide synthase 2, inducible	Mus musculus	71-75
18838692-3	2008	We recently found that the anti-inflammatory potencies (suppression of iNOS and COX-2 expression) of a series of triterpenoids with Michael reaction centers were closely correlated with the potencies of these agents to induce the phase 2 response.	triterpenoids	113-126	cytochrome c oxidase II, mitochondrial	Mus musculus	80-85
18757413-0	2008	Glycogen synthase kinase 3beta regulates cell death induced by synthetic triterpenoids.	triterpenoids	73-86	glycogen synthase kinase 3 beta	Homo sapiens	0-30
17361329-0	2007	Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling.	triterpenoids	10-23	notch receptor 1	Homo sapiens	159-165
18065492-7	2007	Several known individual molecular targets of CDDO-Me and related triterpenoids that are relevant to all of these findings include nuclear factor-kappaB signaling, signal transducers and activators of transcription signaling, and transforming growth factor-beta signaling, as well as Keap1, the endogenous inhibitor of the transcription factor Nrf2.	triterpenoids	66-79	nuclear factor, erythroid derived 2, like 2	Mus musculus	344-348
17822364-0	2007	Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.	triterpenoids	56-69	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
17361329-0	2007	Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling.	triterpenoids	10-23	AKT serine/threonine kinase 1	Homo sapiens	140-143
17889544-5	2007	Furthermore, the four triterpenoids were also active toward a multidrug resistant (MDR) leukemia cell line, overexpressing glycoprotein-P (P-gp).	triterpenoids	22-35	phosphoglycolate phosphatase	Homo sapiens	139-143
17917299-9	2007	A precise triterpenoid quantification using synthesized deuterated compounds of beta-amyrin (1), alpha-amyrin (2), and lupeol (3) showed that the levels of triterpenoids in hmg1 and hmg2 were 65% and 25% lower than in the wild type (WT), respectively.	triterpenoids	156-169	hydroxy methylglutaryl CoA reductase 1	Arabidopsis thaliana	173-177
17237276-0	2007	Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.	triterpenoids	52-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-106
17711345-3	2007	A (13)C NMR-based general rule for assignment of the C-21 configuration in the side chain of apotirucallane- and tirucallane-type triterpenoids was proposed.	triterpenoids	130-143	TBL1X/Y related 1	Homo sapiens	53-57
17503850-2	2007	In addition, these triterpenoids have been tested for their inhibitory effects on activation of (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor, as a primary screening test for anti-tumor initiators.	triterpenoids	19-32	nuclear receptor subfamily 4 group A member 3	Homo sapiens	165-170
17136324-0	2006	Ursane triterpenoids inhibit atherosclerosis and xanthoma in LDL receptor knockout mice.	triterpenoids	7-20	low density lipoprotein receptor	Mus musculus	61-73
16489057-11	2006	The unparalleled potency of CDDO-Im in vivo highlights the chemopreventive promise of targeting Nrf2 pathways with triterpenoids.	triterpenoids	115-128	NFE2 like bZIP transcription factor 2	Rattus norvegicus	96-100
16830816-1	2006	Cycloartane triterpenoids, which exist widely in nature, are mainly distributed in Astragalus (Leguminosae) species, Trib.	triterpenoids	12-25	RIB43A domain with coiled-coils 2	Homo sapiens	117-121
16202612-0	2006	Tyrosinase inhibitory cycloartane type triterpenoids from the methanol extract of the whole plant of Amberboa ramosa Jafri and their structure-activity relationship.	triterpenoids	39-52	tyrosinase	Homo sapiens	0-10
16202612-1	2006	New tyrosinase inhibitory cycloartane triterpenoids have been discovered from the methanol extract of the whole plant of Amberboa ramosa (Roxb.)	triterpenoids	38-51	tyrosinase	Homo sapiens	4-14
16818503-8	2006	This indicates that activation of the Smad signaling pathway by triterpenoids is an important mechanism of monocytic differentiation.	triterpenoids	64-77	SMAD family member 4	Homo sapiens	38-42
16435854-0	2006	A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants.	triterpenoids	40-53	lanosterol synthase	Homo sapiens	59-78
15930299-0	2005	The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.	triterpenoids	14-27	heme oxygenase 1	Homo sapiens	79-95
16405902-6	2006	The five triterpenoids used in the present experiment significantly suppressed N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation in concentration-dependent manner.	triterpenoids	9-22	formyl peptide receptor 1	Homo sapiens	120-124
16364033-0	2006	Phytocomponents of triterpenoids, oleanolic acid and ursolic acid, regulated differently the processing of epidermal keratinocytes via PPAR-alpha pathway.	triterpenoids	19-32	peroxisome proliferator activated receptor alpha	Homo sapiens	135-145
15930299-0	2005	The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.	triterpenoids	14-27	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
15930299-3	2005	Transfection studies using a series of reporter constructs show that activation of the human HO-1 promoter by the triterpenoids requires an antioxidant response element (ARE), a cyclic AMP response element, and an E Box sequence.	triterpenoids	114-127	heme oxygenase 1	Homo sapiens	93-97
15930299-7	2005	These studies are the first to investigate the induction of the HO-1 and Nrf2/ARE pathways by CDDO and CDDO-Im, and our results suggest that further in vivo studies are needed to explore the chemopreventive and chemotherapeutic potential of the triterpenoids.	triterpenoids	245-258	heme oxygenase 1	Homo sapiens	64-68
15930300-3	2005	We have identified synthetic triterpenoids, including 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and its derivative 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole (CDDO-Im), which sensitize TRAIL-resistant cancer cells to TRAIL-mediated apoptosis.	triterpenoids	29-42	TNF superfamily member 10	Homo sapiens	208-213
15930300-3	2005	We have identified synthetic triterpenoids, including 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and its derivative 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole (CDDO-Im), which sensitize TRAIL-resistant cancer cells to TRAIL-mediated apoptosis.	triterpenoids	29-42	TNF superfamily member 10	Homo sapiens	240-245
15930300-6	2005	The combination of triterpenoids and monoclonal anti-TRAIL receptor-1 (DR4) antibody also induces apoptosis of breast cancer cells in vitro.	triterpenoids	19-32	TNF receptor superfamily member 10a	Homo sapiens	71-74
15124099-3	2004	Triterpenoids esterified with malonic acid at C-3 possessed the strongest hemolytic activity among the tested compounds.	triterpenoids	0-13	complement C3	Homo sapiens	46-49
15798995-0	2005	Bioactive triterpenoids from Vochysia pacifica interact with cyclic nucleotide phosphodiesterase isozyme PDE4.	triterpenoids	10-23	phosphodiesterase 4A	Homo sapiens	105-109
12943194-1	2003	Fifteen new ursolic and betulinic triterpenoids, bearing various functionalities at C-3 and C-28 were synthesized as potential cytotoxic agents.	triterpenoids	34-47	complement C3	Homo sapiens	84-87
12931220-0	2003	Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL.	triterpenoids	10-23	TNF superfamily member 10	Homo sapiens	124-129
12186419-0	2002	Effects of oleanane-type triterpenoids from fabaceous plants on the expression of ICAM-1.	triterpenoids	25-38	intercellular adhesion molecule 1	Homo sapiens	82-88
12649201-0	2003	Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling.	triterpenoids	10-23	transforming growth factor beta 1	Homo sapiens	32-63
12649201-0	2003	Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling.	triterpenoids	10-23	SMAD family member 7	Homo sapiens	64-68
12649201-6	2003	Finally, these triterpenoids induce expression of the transcriptional coactivator p300-CBP-associated factor and synergize with TGF-beta in this regard.	triterpenoids	15-28	lysine acetyltransferase 2B	Homo sapiens	82-108
12649201-6	2003	Finally, these triterpenoids induce expression of the transcriptional coactivator p300-CBP-associated factor and synergize with TGF-beta in this regard.	triterpenoids	15-28	transforming growth factor beta 1	Homo sapiens	128-136
12649201-7	2003	These are the first studies to report enhancement of Smad signaling by synthetic triterpenoids and should further their optimal use for applications in prevention or treatment of diseases in which there is aberrant function of TGF-beta.	triterpenoids	81-94	SMAD family member 7	Homo sapiens	53-57
12649201-7	2003	These are the first studies to report enhancement of Smad signaling by synthetic triterpenoids and should further their optimal use for applications in prevention or treatment of diseases in which there is aberrant function of TGF-beta.	triterpenoids	81-94	transforming growth factor beta 1	Homo sapiens	227-235
12367771-4	2002	RESULTS: The superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) was significantly suppressed by betulin and lupeol depending on the concentration of the triterpenoids.	triterpenoids	182-195	formyl peptide receptor 1	Homo sapiens	87-91
12186419-1	2002	We examined the inhibitory effects of oleanane-type triterpenoids from fabaceous plants on the TNF-alpha-induced expression of cell adhesion molecules on THP-1 human monocytic leukemia cells and compared them with a glucocorticoid dexamethasone.	triterpenoids	52-65	tumor necrosis factor	Homo sapiens	95-104
12186419-1	2002	We examined the inhibitory effects of oleanane-type triterpenoids from fabaceous plants on the TNF-alpha-induced expression of cell adhesion molecules on THP-1 human monocytic leukemia cells and compared them with a glucocorticoid dexamethasone.	triterpenoids	52-65	GLI family zinc finger 2	Homo sapiens	154-159
10968284-4	2000	Bioassay-guided fractionation of the extract, guided by an assay to detect DNA polymerase beta inhibition, resulted in the isolation of six active pentacyclic triterpenoids (1-6).	triterpenoids	159-172	DNA polymerase beta	Homo sapiens	75-94
12007601-2	2002	These triterpenoids showed an inhibitory effect against enzymes involved in replication, such as calf DNA polymerase alpha (pol alpha) and rat DNA polymerase beta (pol beta).	triterpenoids	6-19	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	124-133
12007601-2	2002	These triterpenoids showed an inhibitory effect against enzymes involved in replication, such as calf DNA polymerase alpha (pol alpha) and rat DNA polymerase beta (pol beta).	triterpenoids	6-19	DNA polymerase beta	Rattus norvegicus	143-162
12007601-2	2002	These triterpenoids showed an inhibitory effect against enzymes involved in replication, such as calf DNA polymerase alpha (pol alpha) and rat DNA polymerase beta (pol beta).	triterpenoids	6-19	DNA polymerase beta	Rattus norvegicus	164-172
10970789-6	2000	Here we report that all of these triterpenoids are potent inhibitors of calf DNA polymerase alpha, rat DNA polymerase beta and human DNA topoisomerases I and II, and show moderate inhibitory effects on plant DNA polymerase II and human immunodeficiency virus reverse transcriptase.	triterpenoids	33-46	DNA polymerase beta	Rattus norvegicus	103-122
10794703-3	2000	On the basis of the structure of B-15, 19 novel olean- and urs-12-ene triterpenoids with a 1-en-3-one functionality having a substituent at C-2 in ring A have been designed and synthesized.	triterpenoids	70-83	complement component 2 (within H-2S)	Mus musculus	140-143
10968284-5	2000	These triterpenoids had IC50 values ranging from 7.5 to 16 microM in the presence of bovine serum albumin (BSA) and 2.6-5.8 microM in the absence of BSA, consistent with the possibility that these inhibitors may be of use in vivo.	triterpenoids	6-19	albumin	Homo sapiens	92-105
8588874-9	1996	Crocetin and the plant-derived amphiphilic triterpenoids described here are the most potent non-aromatic plant-derived inhibitors of cAK yet found.	triterpenoids	43-56	cyclin-dependent kinase 7	Rattus norvegicus	133-136
10654412-3	1999	Bioassay-guided fractionation of the extract, using an assay to monitor the inhibitory potential of individual fractions toward DNA polymerase beta, led to the isolation of four active ursane and oleanane triterpenoids (1-4).	triterpenoids	205-218	DNA polymerase beta	Homo sapiens	128-147
8588874-0	1996	Selective inhibition of cyclic AMP-dependent protein kinase by amphiphilic triterpenoids and related compounds.	triterpenoids	75-88	cyclin-dependent kinase 7	Rattus norvegicus	24-59
8588874-1	1996	A set of plant- and animal-derived amphiphilic triterpenoids have been shown to be potent and selective inhibitors of the catalytic subunit of rat liver cyclic AMP-dependent protein kinase (cAK).	triterpenoids	47-60	cyclin-dependent kinase 7	Rattus norvegicus	153-188
8588874-1	1996	A set of plant- and animal-derived amphiphilic triterpenoids have been shown to be potent and selective inhibitors of the catalytic subunit of rat liver cyclic AMP-dependent protein kinase (cAK).	triterpenoids	47-60	cyclin-dependent kinase 7	Rattus norvegicus	190-193
8588874-5	1996	A variety of triterpenoids not possessing this structural motif are relatively inactive as inhibitors of cAK and of CDPK, PKC and MLCK.	triterpenoids	13-26	cyclin-dependent kinase 7	Rattus norvegicus	105-108
8588874-5	1996	A variety of triterpenoids not possessing this structural motif are relatively inactive as inhibitors of cAK and of CDPK, PKC and MLCK.	triterpenoids	13-26	calcium-dependent protein kinase 19	Triticum aestivum	116-120
9485026-0	1998	Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages.	triterpenoids	6-19	nitric oxide synthase 2, inducible	Mus musculus	29-60
9485026-0	1998	Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages.	triterpenoids	6-19	nitric oxide synthase 2, inducible	Mus musculus	62-66
9485026-0	1998	Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages.	triterpenoids	6-19	cytochrome c oxidase II, mitochondrial	Mus musculus	98-103
9485026-2	1998	These triterpenoids have been tested for their ability to suppress the de novo formation of two enzymes, inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), using IFN-gamma-stimulated primary mouse macrophages or lipopolysaccharide (LPS)-activated RAW 264.7 macrophages as assay systems.	triterpenoids	6-19	nitric oxide synthase 2, inducible	Mus musculus	105-136
9485026-2	1998	These triterpenoids have been tested for their ability to suppress the de novo formation of two enzymes, inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), using IFN-gamma-stimulated primary mouse macrophages or lipopolysaccharide (LPS)-activated RAW 264.7 macrophages as assay systems.	triterpenoids	6-19	nitric oxide synthase 2, inducible	Mus musculus	138-142
9485026-2	1998	These triterpenoids have been tested for their ability to suppress the de novo formation of two enzymes, inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), using IFN-gamma-stimulated primary mouse macrophages or lipopolysaccharide (LPS)-activated RAW 264.7 macrophages as assay systems.	triterpenoids	6-19	cytochrome c oxidase II, mitochondrial	Mus musculus	174-179
9485026-2	1998	These triterpenoids have been tested for their ability to suppress the de novo formation of two enzymes, inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), using IFN-gamma-stimulated primary mouse macrophages or lipopolysaccharide (LPS)-activated RAW 264.7 macrophages as assay systems.	triterpenoids	6-19	interferon gamma	Mus musculus	188-197
9485026-2	1998	These triterpenoids have been tested for their ability to suppress the de novo formation of two enzymes, inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), using IFN-gamma-stimulated primary mouse macrophages or lipopolysaccharide (LPS)-activated RAW 264.7 macrophages as assay systems.	triterpenoids	6-19	toll-like receptor 4	Mus musculus	258-261
18975157-0	1997	Suppressive effects of triterpenoids on CINC-1 induction in interleukin-1beta-stimulated rat fibroblast NRK-49F cells.	triterpenoids	23-36	C-X-C motif chemokine ligand 1	Rattus norvegicus	40-46
18975157-0	1997	Suppressive effects of triterpenoids on CINC-1 induction in interleukin-1beta-stimulated rat fibroblast NRK-49F cells.	triterpenoids	23-36	interleukin 1 beta	Rattus norvegicus	60-77
8588874-5	1996	A variety of triterpenoids not possessing this structural motif are relatively inactive as inhibitors of cAK and of CDPK, PKC and MLCK.	triterpenoids	13-26	myosin light chain kinase 3	Rattus norvegicus	130-134
31391686-2	2019	Triterpenoids of natural and synthetic origin reported as anticancer agents with apoptotic potential and hence may prove to be good candidates for in silico testing against caspases-3 and 8.	triterpenoids	0-13	caspase 3	Homo sapiens	173-189
22685453-5	2012	While clinical trials in cancer patients with thiazolidinediones (TZD) have been disappointing, novel structurally different PPARgamma ligands, including triterpenoids, have entered clinical arena as therapeutic agents for epithelial and hematopoietic malignancies.	triterpenoids	154-167	peroxisome proliferator activated receptor gamma	Homo sapiens	125-134
30703491-0	2019	Neutrophil elastase inhibitory effects of pentacyclic triterpenoids from Eriobotrya japonica (loquat leaves).	triterpenoids	54-67	elastase, neutrophil expressed	Homo sapiens	0-19
30703491-2	2019	AIM OF THE STUDY: Pentacyclic triterpenoids (PTs), especially ursolic acid (UA), have been found as reversibly and competitively human neutrophil elastase (HNE) inhibitors.	triterpenoids	30-43	elastase, neutrophil expressed	Homo sapiens	135-154
31384540-0	2019	Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with anti-inflammatory activity in Caco-2 cells.	triterpenoids	35-48	cytokine like 1	Homo sapiens	6-10
31384540-2	2019	Structurally, alisolides A-F (1-6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids.	triterpenoids	143-156	cytokine like 1	Homo sapiens	114-118
31077913-1	2019	A series of nineteen nitrogen-containing lupane triterpenoids was obtained by modification of C2, C3, C20 and C28 positions of betulonic acid and their alpha-glucosidase inhibiting activity was investigated.	triterpenoids	48-61	sucrase-isomaltase	Homo sapiens	152-169
31391686-4	2019	Protein structure of caspase-3 (3DEI) and caspase-8 (3KJQ) was obtained from the protein data bank and docked with selected triterpenoids using AutoDock Tools and AutoDock Vina.	triterpenoids	124-137	caspase 8	Homo sapiens	42-51
8328279-1	1993	A new triterpenoid, squasapogenol (S-11), was isolated from the hydrolytic products of dilute ethanol (10%) extract of the roots of Glycyrrhiza squamulosa Franch, along with four known triterpenoids.	triterpenoids	185-198	surface antigen (X-linked) 2	Homo sapiens	35-39
31175950-0	2019	Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1.	triterpenoids	33-46	carboxylesterase 1	Homo sapiens	96-114
31175950-2	2019	In this study, a series of natural pentacyclic triterpenoids were collected and their inhibitory effects against CES1 and CES2 were assayed using D-luciferin methyl ester (DME) and N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinolin- 6-yl)- 2-chloroacetamide (NCEN) as specific optical substrate for CES1, and CES2, respectively.	triterpenoids	47-60	carboxylesterase 1	Homo sapiens	113-117
31175950-2	2019	In this study, a series of natural pentacyclic triterpenoids were collected and their inhibitory effects against CES1 and CES2 were assayed using D-luciferin methyl ester (DME) and N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinolin- 6-yl)- 2-chloroacetamide (NCEN) as specific optical substrate for CES1, and CES2, respectively.	triterpenoids	47-60	carboxylesterase 2	Homo sapiens	122-126
31175950-2	2019	In this study, a series of natural pentacyclic triterpenoids were collected and their inhibitory effects against CES1 and CES2 were assayed using D-luciferin methyl ester (DME) and N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinolin- 6-yl)- 2-chloroacetamide (NCEN) as specific optical substrate for CES1, and CES2, respectively.	triterpenoids	47-60	carboxylesterase 1	Homo sapiens	306-310
31175950-2	2019	In this study, a series of natural pentacyclic triterpenoids were collected and their inhibitory effects against CES1 and CES2 were assayed using D-luciferin methyl ester (DME) and N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinolin- 6-yl)- 2-chloroacetamide (NCEN) as specific optical substrate for CES1, and CES2, respectively.	triterpenoids	47-60	carboxylesterase 2	Homo sapiens	316-320
30772482-0	2019	Inhibitory ASIC2-mediated calcineurin/NFAT against colorectal cancer by triterpenoids extracted from Rhus chinensis Mill.	triterpenoids	72-85	acid sensing ion channel subunit 2	Homo sapiens	11-16
30772482-16	2019	Our findings thus provided rational evidence that inhibition of the ASIC2-induced calcineurin/NFAT pathway by triterpenoids in Rhus chinensis Mill.	triterpenoids	110-123	acid sensing ion channel subunit 2	Homo sapiens	68-73
31391686-4	2019	Protein structure of caspase-3 (3DEI) and caspase-8 (3KJQ) was obtained from the protein data bank and docked with selected triterpenoids using AutoDock Tools and AutoDock Vina.	triterpenoids	124-137	caspase 3	Homo sapiens	21-30
29600756-9	2019	RESULTS: The results showed that more than 50 natural inhibitors of CES1 or CES2, including phenolic chemicals, triterpenoids, and tanshinones were found from herbs, whereas only few inducers of CES1 and CES2 were reported.	triterpenoids	112-125	carboxylesterase 1	Homo sapiens	68-72
30976052-0	2019	The enzymes OSC1 and CYP716A263 produce a high variety of triterpenoids in the latex of Taraxacum koksaghyz.	triterpenoids	58-71	F1F0 ATP synthase subunit 5	Saccharomyces cerevisiae S288C	12-16
30381614-7	2019	The potential of previously reported triterpenoids in blocking hexokinase II (HK2) activity inspired us to investigate the inhibition effect of PA on HK2 activity.	triterpenoids	37-50	hexokinase 2	Homo sapiens	78-81
29600756-9	2019	RESULTS: The results showed that more than 50 natural inhibitors of CES1 or CES2, including phenolic chemicals, triterpenoids, and tanshinones were found from herbs, whereas only few inducers of CES1 and CES2 were reported.	triterpenoids	112-125	carboxylesterase 2	Homo sapiens	76-80
30563240-0	2018	Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane-X-Receptor.	triterpenoids	46-59	nuclear receptor subfamily 1 group I member 2	Homo sapiens	144-163
29719882-7	2018	On the other hand, inactivation of protein kinase B (Akt) resulted in a suppression of neurite lengthening in all studied triterpenoids.	triterpenoids	122-135	thymoma viral proto-oncogene 1	Mus musculus	53-56
30583632-0	2018	[Effect of total triterpenoids of Chaenomeles speciosa on PPARgamma/SIRT1/NF-kappaBp65 signaling pathway and intestinal mucosal barrier of ulcerative colitis induced by DSS in mice].	triterpenoids	17-30	peroxisome proliferator activated receptor gamma	Mus musculus	58-67
30583632-0	2018	[Effect of total triterpenoids of Chaenomeles speciosa on PPARgamma/SIRT1/NF-kappaBp65 signaling pathway and intestinal mucosal barrier of ulcerative colitis induced by DSS in mice].	triterpenoids	17-30	sirtuin 1	Mus musculus	68-73
30583632-1	2018	To observe the effect of total triterpenoids of Chaenomeles speciosa on PPARgamma/SIRT1/NF-kappaBp65 signaling pathway and intestinal mucosal barrier of ulcerative colitis induced by dextran sulfate sodium (DSS) in mice, C57BL/6 mice were randomly divided into normal group, model group, total triterpenoids of C. speciosa (50, 100 mg kg-1) groups and sulfasalazine (250 mg kg-1) group.	triterpenoids	31-44	peroxisome proliferator activated receptor gamma	Mus musculus	72-81
30583632-8	2018	These findings suggested that total triterpenoids of C. speciosa had a significantly therapeutic effect on UC mice induced by DSS, its mechanism might be related to the regulation of PPARgamma/SIRT1/NF-kappaBp65 signaling pathway, the inhibition of pro-inflammatory factor formation and the up-regulation of protein expression of protective factors.	triterpenoids	36-49	peroxisome proliferator activated receptor gamma	Mus musculus	183-192
30583632-8	2018	These findings suggested that total triterpenoids of C. speciosa had a significantly therapeutic effect on UC mice induced by DSS, its mechanism might be related to the regulation of PPARgamma/SIRT1/NF-kappaBp65 signaling pathway, the inhibition of pro-inflammatory factor formation and the up-regulation of protein expression of protective factors.	triterpenoids	36-49	sirtuin 1	Mus musculus	193-198
30320262-4	2018	Considering that triterpenoids from natural sources have been identified as inhibitors of nuclear factor kappa-light-chain-enhancer of activated B cell (NF-kappaB) signaling, docking studies were conducted to evaluate whether NF-kappaB may be a potential target.	triterpenoids	17-30	nuclear factor kappa B subunit 1	Homo sapiens	153-162
30320262-4	2018	Considering that triterpenoids from natural sources have been identified as inhibitors of nuclear factor kappa-light-chain-enhancer of activated B cell (NF-kappaB) signaling, docking studies were conducted to evaluate whether NF-kappaB may be a potential target.	triterpenoids	17-30	nuclear factor kappa B subunit 1	Homo sapiens	226-235
29793143-1	2018	A set of triterpenoids with different grades of oxidation in the lupane skeleton were prepared and evaluated as cholinesterase inhibitors.	triterpenoids	9-22	butyrylcholinesterase	Homo sapiens	112-126
30359578-0	2018	C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells.	triterpenoids	27-40	TNF superfamily member 10	Homo sapiens	53-58
30359578-0	2018	C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells.	triterpenoids	27-40	mitogen-activated protein kinase 14	Homo sapiens	77-80
30359578-0	2018	C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells.	triterpenoids	27-40	DNA damage inducible transcript 3	Homo sapiens	90-94
30359578-0	2018	C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells.	triterpenoids	27-40	TNF receptor superfamily member 10b	Homo sapiens	104-107
30217066-9	2018	Moreover, 15-O-glycosylation is a new microbial biotransformation of triterpenoids, and the biotransformed metabolite, GAA-15-O-beta-glucoside, is a new compound.	triterpenoids	69-82	alpha glucosidase	Danio rerio	119-122
30057155-0	2018	Cytotoxic and NF-kappaB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives.	triterpenoids	89-102	nuclear factor kappa B subunit 1	Homo sapiens	14-23
28856520-3	2018	However, pentacyclic triterpenoids also modulate the expression and transcriptional activities of Nrf2 and exert cytoprotective effects.	triterpenoids	21-34	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
29655695-13	2018	The interaction between triterpenoids and FXR were evaluated by luciferase assay and molecular docking.	triterpenoids	24-37	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	42-45
29655695-16	2018	Luciferase assay and molecular docking results indicated that triterpenoids could activate FXR, which resulting in ameliorative accumulation of bile acids in the liver by increase of metabolism and transportation for bile acids, and decrease of synthesis for bile acids.	triterpenoids	62-75	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	91-94