PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27639291-2	2016	During the early postnatal development, very low/low frequency (0.033-1Hz) activation of previously non-stimulated (naive) SC synapses (SR-CA1 synapses) results in a stimulus-, but not frequency-, dependent depression which is explained by postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) silencing.	1HZ	70-73	carbonic anhydrase 1	Rattus norvegicus	139-142
32463098-3	2020	The present study aimed at investigating whether ACE2 is involved in physiological stretch (10% elongation, 1Hz) mediated cellular functions and the underlying mechanism.	1HZ	108-111	angiotensin converting enzyme 2	Homo sapiens	49-53
28687447-11	2017	These findings suggest that 1Hz rTMS over the SMA can be an efficient and safe add-on therapeutic method in treatment-resistant patients with OCD.	1HZ	28-31	survival of motor neuron 1, telomeric	Homo sapiens	46-49
28536052-9	2017	CONCLUSIONS: Application of 1Hz rTMS over M1 resulted in changes of rCBF in contralateral M1 and PM, which seemed to constitute a function of interhemispheric modulation of rTMS.	1HZ	28-31	CCAAT/enhancer binding protein zeta	Rattus norvegicus	68-72
27639291-5	2016	Here, using field recordings of synaptic activity in hippocampal slices from 2nd postnatal week rats, we found that SLM-CA1 synapses are also readily depressed by activity in the very low/low frequency range (0.033-1Hz).	1HZ	215-218	carbonic anhydrase 1	Rattus norvegicus	120-123
29714946-1	2016	This study is aimed to investigate the effects of mechanical stretch on the expression of transforming growth factor-beta1(TGF-beta1)and fibroblast growth factor-2(FGF-2),and the signaling pathway in human bronchial epithelioid(16HBE)cells under mechanical stretch.Using loading device with flexible substrate(FX-4000T)to stretch 16 HBE cells,we found that the stretching elongation was 15%,at frequency of 1Hz,stretching for 0.5h,1h,1.5hand 2h.Choosing the higher expression of TGF-beta1,FGF-2and Ca2+group to carry out intervention experiments,we used the cells pretreated with canonical transient receptor potential 1(TRPC1)channel antagonist SKF96365,protein kinase C(PKC)inhibitor HA-100,and thereafter mechanical stretch to interpose.Compared with those in the blank control group,TGF-beta1and FGF-2"protein and mRNA,intracellular Ca2+fluorescence intensity were higher,and the differences were statistically significant(P<0.05)at the 4time points,0.5h,1h,1.5h and 2h.At 0.5h,the increasing rate was the highest.TGF-beta1protein and mRNA,FGF-2protein and mRNA,intracellular Ca2+luorescence intensity in the stretch+SKF96365and stretch+ HA-100 intervented group were decreased,the differences were statistically significant than those in 0.5hstretch group(P<0.05)without intervention.The expression of TGF-beta1,FGF-2 was up-regulated in 16 HBE cells under mechanical stretch,PKC,TRPC1,and Ca2+may participate in the signal path.	1HZ	407-410	transforming growth factor beta 1	Homo sapiens	90-122
29714946-1	2016	This study is aimed to investigate the effects of mechanical stretch on the expression of transforming growth factor-beta1(TGF-beta1)and fibroblast growth factor-2(FGF-2),and the signaling pathway in human bronchial epithelioid(16HBE)cells under mechanical stretch.Using loading device with flexible substrate(FX-4000T)to stretch 16 HBE cells,we found that the stretching elongation was 15%,at frequency of 1Hz,stretching for 0.5h,1h,1.5hand 2h.Choosing the higher expression of TGF-beta1,FGF-2and Ca2+group to carry out intervention experiments,we used the cells pretreated with canonical transient receptor potential 1(TRPC1)channel antagonist SKF96365,protein kinase C(PKC)inhibitor HA-100,and thereafter mechanical stretch to interpose.Compared with those in the blank control group,TGF-beta1and FGF-2"protein and mRNA,intracellular Ca2+fluorescence intensity were higher,and the differences were statistically significant(P<0.05)at the 4time points,0.5h,1h,1.5h and 2h.At 0.5h,the increasing rate was the highest.TGF-beta1protein and mRNA,FGF-2protein and mRNA,intracellular Ca2+luorescence intensity in the stretch+SKF96365and stretch+ HA-100 intervented group were decreased,the differences were statistically significant than those in 0.5hstretch group(P<0.05)without intervention.The expression of TGF-beta1,FGF-2 was up-regulated in 16 HBE cells under mechanical stretch,PKC,TRPC1,and Ca2+may participate in the signal path.	1HZ	407-410	transforming growth factor beta 1	Homo sapiens	123-132
29714946-1	2016	This study is aimed to investigate the effects of mechanical stretch on the expression of transforming growth factor-beta1(TGF-beta1)and fibroblast growth factor-2(FGF-2),and the signaling pathway in human bronchial epithelioid(16HBE)cells under mechanical stretch.Using loading device with flexible substrate(FX-4000T)to stretch 16 HBE cells,we found that the stretching elongation was 15%,at frequency of 1Hz,stretching for 0.5h,1h,1.5hand 2h.Choosing the higher expression of TGF-beta1,FGF-2and Ca2+group to carry out intervention experiments,we used the cells pretreated with canonical transient receptor potential 1(TRPC1)channel antagonist SKF96365,protein kinase C(PKC)inhibitor HA-100,and thereafter mechanical stretch to interpose.Compared with those in the blank control group,TGF-beta1and FGF-2"protein and mRNA,intracellular Ca2+fluorescence intensity were higher,and the differences were statistically significant(P<0.05)at the 4time points,0.5h,1h,1.5h and 2h.At 0.5h,the increasing rate was the highest.TGF-beta1protein and mRNA,FGF-2protein and mRNA,intracellular Ca2+luorescence intensity in the stretch+SKF96365and stretch+ HA-100 intervented group were decreased,the differences were statistically significant than those in 0.5hstretch group(P<0.05)without intervention.The expression of TGF-beta1,FGF-2 was up-regulated in 16 HBE cells under mechanical stretch,PKC,TRPC1,and Ca2+may participate in the signal path.	1HZ	407-410	fibroblast growth factor 2	Homo sapiens	164-169
25172625-6	2014	Interestingly, rTMS with low intensity (110% average resting motor threshold intensity, 1Hz, LIMS) triggered the activation of BDNF and TrkB, upregulated the level of synaptic protein markers, and increased synapse density and thickened PSD, and further reversed the spatial cognition dysfunction in aging mice.	1HZ	88-91	brain derived neurotrophic factor	Mus musculus	127-131
25172625-6	2014	Interestingly, rTMS with low intensity (110% average resting motor threshold intensity, 1Hz, LIMS) triggered the activation of BDNF and TrkB, upregulated the level of synaptic protein markers, and increased synapse density and thickened PSD, and further reversed the spatial cognition dysfunction in aging mice.	1HZ	88-91	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	136-140
25108227-7	2014	Cyclical mechanical stretch (10% cyclic equibiaxial stretch, 1Hz) induced hypertrophy of primary rabbit cardiomyocytes in vitro and enhanced ANP, IL-18, and IL-18Ralpha expression.	1HZ	61-64	interleukin-18	Oryctolagus cuniculus	146-151
23174210-5	2013	In the results, the ipsi-M1 excitability induced in response to single-pulse TMS was significantly decreased in the 2 Hz conditions, compared with the 1Hz and 3Hz conditions.	1HZ	151-154	myoregulin	Homo sapiens	25-27
25038415-3	2014	1Hz repetitive transcranial magnetic stimulation (rTMS) trains were applied over the SMA of healthy subjects performing a task requiring to judge the valence and arousal of emotional stimuli.	1HZ	0-3	survival of motor neuron 1, telomeric	Homo sapiens	85-88
23524265-5	2013	Oscillatory (1Hz) shear stress (10 dynes/cm2) increased TCF/LEF activity and stimulated translocation of beta-catenin to the nucleus with the distinct activity patterns of Rac1 and Cdc42.	1HZ	13-16	catenin (cadherin associated protein), beta 1	Mus musculus	105-117
23524265-5	2013	Oscillatory (1Hz) shear stress (10 dynes/cm2) increased TCF/LEF activity and stimulated translocation of beta-catenin to the nucleus with the distinct activity patterns of Rac1 and Cdc42.	1HZ	13-16	Rac family small GTPase 1	Mus musculus	172-176
23524265-5	2013	Oscillatory (1Hz) shear stress (10 dynes/cm2) increased TCF/LEF activity and stimulated translocation of beta-catenin to the nucleus with the distinct activity patterns of Rac1 and Cdc42.	1HZ	13-16	cell division cycle 42	Mus musculus	181-186
23201339-3	2013	Similarly, both intensities of low frequency magnetic stimulation (1Hz) activated brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) pathways, including the pathways for mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) and for phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt).	1HZ	67-70	brain derived neurotrophic factor	Homo sapiens	82-115
23201339-3	2013	Similarly, both intensities of low frequency magnetic stimulation (1Hz) activated brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) pathways, including the pathways for mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) and for phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt).	1HZ	67-70	brain derived neurotrophic factor	Homo sapiens	117-121
23201339-3	2013	Similarly, both intensities of low frequency magnetic stimulation (1Hz) activated brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) pathways, including the pathways for mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) and for phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt).	1HZ	67-70	neurotrophic receptor tyrosine kinase 2	Homo sapiens	127-155
23201339-3	2013	Similarly, both intensities of low frequency magnetic stimulation (1Hz) activated brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) pathways, including the pathways for mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) and for phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt).	1HZ	67-70	neurotrophic receptor tyrosine kinase 2	Homo sapiens	157-161
23201339-3	2013	Similarly, both intensities of low frequency magnetic stimulation (1Hz) activated brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) pathways, including the pathways for mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) and for phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt).	1HZ	67-70	AKT serine/threonine kinase 1	Homo sapiens	343-346
21925507-8	2011	Additionally, functional potentiation was maintained with Rrm1+Rrm2 overexpression as stimulation frequency was increased (1Hz and 2Hz).	1HZ	123-126	ribonucleotide reductase catalytic subunit M1	Rattus norvegicus	58-62
21925507-8	2011	Additionally, functional potentiation was maintained with Rrm1+Rrm2 overexpression as stimulation frequency was increased (1Hz and 2Hz).	1HZ	123-126	ribonucleotide reductase regulatory subunit M2	Rattus norvegicus	63-67
21803333-8	2011	In EPO-perfused slices significant bigger responses were obtained (1Hz, 101.12+-5.69%, 10Hz, 123.24+-2.68, and 100Hz, 216.41+-20.1) when compared to the control slices.	1HZ	67-70	erythropoietin	Mus musculus	3-6
19433335-3	2009	ANG II increased the frequency of action potentials (AP) produced by supramaximal 500 ms depolarizing currents recorded in both tonic (16 Hz vs. 58 Hz, control vs. ANG II perfusion respectively, n=9) and phasic (1Hz vs. 38 Hz, n=13) NGNs.	1HZ	212-215	angiotensinogen	Rattus norvegicus	0-6
12730276-10	2003	Accordingly, tonic block of NaV1.8 channels by vinpocetine (3 microM) increased proportionally with increasing depolarizing commands over the frequency range 0.1 to 1Hz.	1HZ	165-168	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	28-34
17368720-2	2007	In the hippocampal CA1 region of young animals, conversion of silent synapses to functional synapses occurs rapidly after pairing post-synaptic depolarization with 1Hz pre-synaptic stimulation, a protocol that also induces long-term potentiation (LTP).	1HZ	164-167	carbonic anhydrase 1	Homo sapiens	19-22
12480484-4	2002	Single-pulse (<1Hz) TMS is safe in normal subjects.	1HZ	18-21	PYD and CARD domain containing	Homo sapiens	23-26
11690727-11	2001	Electrical stimulation of MPO at 1Hz excited 27%, inhibited 3%, and had no effect on 70% of NRM cells.	1HZ	33-36	myeloperoxidase	Rattus norvegicus	26-29
34507817-7	2021	RESULTS: Reverse transcription polymerase chain reaction assays showed that the expression of osteopontin was enhanced 30 minutes after 25G-1Hz 5 minutes of stimulation.	1HZ	140-143	secreted phosphoprotein 1	Homo sapiens	94-105
34507817-8	2021	Western blotting assays showed that the expression of osteopontin and RUNX2 was upregulated 24 hours after 25G-1Hz 5 minutes of stimulation.	1HZ	111-114	secreted phosphoprotein 1	Homo sapiens	54-65
34507817-8	2021	Western blotting assays showed that the expression of osteopontin and RUNX2 was upregulated 24 hours after 25G-1Hz 5 minutes of stimulation.	1HZ	111-114	RUNX family transcription factor 2	Homo sapiens	70-75