PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27226323-3	2016	Here, we demonstrate that the ecdysone-20-monooxygenase Shade determines pupation timing by converting E to 20-hydroxyecdysone (20E) in the fat body, which is the organ that senses nutritional status.	Ecdysterone	108-126	shade	Drosophila melanogaster	30-55
27475001-2	2016	The expression of the nuclear hormone Bmftz-f1 in the posterior silk gland (PSG) is induced by 20-hydroxyecdysone in vivo and in vitro.	Ecdysterone	95-113	nuclear hormone receptor FTZ-F1	Bombyx mori	38-46
27229883-0	2016	beta-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway.	Ecdysterone	0-16	mitogen-activated protein kinase 14	Homo sapiens	137-140
27229883-0	2016	beta-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway.	Ecdysterone	0-16	mitogen-activated protein kinase 14	Homo sapiens	141-145
27229883-0	2016	beta-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway.	Ecdysterone	0-16	tumor protein p53	Homo sapiens	147-150
27329527-0	2016	20-Hydroxyecdysone stimulates nuclear accumulation of BmNep1, a nuclear ribosome biogenesis-related protein in the silkworm, Bombyx mori.	Ecdysterone	0-18	Nep1 protein	Bombyx mori	54-60
27329527-7	2016	Using BmN cells originally derived from ovaries, we demonstrated that 20-hydroxyecdysone (20E) induced BmNep1 expression and stimulated nuclear accumulation of BmNep1.	Ecdysterone	70-88	Nep1 protein	Bombyx mori	103-109
27329527-7	2016	Using BmN cells originally derived from ovaries, we demonstrated that 20-hydroxyecdysone (20E) induced BmNep1 expression and stimulated nuclear accumulation of BmNep1.	Ecdysterone	70-88	Nep1 protein	Bombyx mori	160-166
27329527-7	2016	Using BmN cells originally derived from ovaries, we demonstrated that 20-hydroxyecdysone (20E) induced BmNep1 expression and stimulated nuclear accumulation of BmNep1.	Ecdysterone	90-93	Nep1 protein	Bombyx mori	103-109
27329527-7	2016	Using BmN cells originally derived from ovaries, we demonstrated that 20-hydroxyecdysone (20E) induced BmNep1 expression and stimulated nuclear accumulation of BmNep1.	Ecdysterone	90-93	Nep1 protein	Bombyx mori	160-166
27365399-0	2016	20-Hydroxyecdysone (20E) Primary Response Gene E75 Isoforms Mediate Steroidogenesis Autoregulation and Regulate Developmental Timing in Bombyx.	Ecdysterone	0-18	nuclear hormone receptor E75	Bombyx mori	47-50
27448766-8	2016	Additionally, studies with inhibitors of both the EGFR and ERK, demonstrated that Ecdysterone activates NOS through modulation of EGFR and ERK.	Ecdysterone	82-93	epidermal growth factor receptor	Oryctolagus cuniculus	50-54
27448766-8	2016	Additionally, studies with inhibitors of both the EGFR and ERK, demonstrated that Ecdysterone activates NOS through modulation of EGFR and ERK.	Ecdysterone	82-93	epidermal growth factor receptor	Oryctolagus cuniculus	130-134
26250909-1	2016	The active form of the Drosophila steroid hormone ecdysone, 20-hydroxyecdysone (20E), binds the heterodimer EcR/USP nuclear receptor to regulate target genes that elicit proliferation, cell death and differentiation during insect development.	Ecdysterone	60-78	Ecdysone receptor	Drosophila melanogaster	108-111
27090809-12	2016	However, 20-hydroxyecdysone treatment decreased HR38 expression.	Ecdysterone	9-27	probable nuclear hormone receptor HR38	Bombyx mori	48-52
26584207-0	2015	Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats.	Ecdysterone	45-49	CREB regulated transcription coactivator 1	Mus musculus	97-103
26802554-6	2016	In this work, we tried to induce the topical effects of Ecd by preparation of more lipophilic complexes, with 2 or 4 molecules of 20-hydroxyecdysone (E20) attached to a relatively large nucleus of the porphyrin.	Ecdysterone	130-148	ecdysoneless cell cycle regulator	Homo sapiens	56-59
26727186-0	2016	BmATG5 and BmATG6 mediate apoptosis following autophagy induced by 20-hydroxyecdysone or starvation.	Ecdysterone	67-85	autophagy 5-like	Bombyx mori	0-6
26584207-0	2015	Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats.	Ecdysterone	25-43	CREB regulated transcription coactivator 1	Mus musculus	97-103
26468126-4	2015	In mutant dmfrn larvae reared under iron replete conditions, the expression of halloween genes is increased and 20-hydroxyecdysone (20E), the active form of ecdysone, is synthesized.	Ecdysterone	112-130	mitoferrin	Drosophila melanogaster	10-15
26048653-0	2015	Phytoestrogen beta-Ecdysterone Protects PC12 Cells Against MPP+-Induced Neurotoxicity In Vitro: Involvement of PI3K-Nrf2-Regulated Pathway.	Ecdysterone	14-30	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	111-120
25920486-2	2015	In this study, we measured the 20-hydroxyecdysone (20E)-induced transcriptional level of the CYP6ab4 gene using reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) with a dual spike-in strategy.	Ecdysterone	31-49	cytochrome P450 6AB4	Bombyx mori	93-100
25920486-2	2015	In this study, we measured the 20-hydroxyecdysone (20E)-induced transcriptional level of the CYP6ab4 gene using reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) with a dual spike-in strategy.	Ecdysterone	51-54	cytochrome P450 6AB4	Bombyx mori	93-100
26289344-4	2015	Here we profile tRNA, transcript and protein levels in Drosophila Kc167 cells, a plasmatocyte cell line that, upon treatment with 20-hydroxyecdysone, differentiates into macrophages.	Ecdysterone	130-148	transfer RNA:Lysine-TTT 2-2	Drosophila melanogaster	16-20
26378227-0	2015	20-Hydroxyecdysone (20E) Primary Response Gene E93 Modulates 20E Signaling to Promote Bombyx Larval-Pupal Metamorphosis.	Ecdysterone	0-18	mushroom body large-type Kenyon cell-specific protein 1	Bombyx mori	47-50
26378227-1	2015	As revealed in a previous microarray study to identify genes regulated by 20-hydroxyecdysone (20E) and juvenile hormone (JH) in the silkworm, Bombyx mori, E93 expression in the fat body was markedly low prior to the wandering stage but abundant during larval-pupal metamorphosis.	Ecdysterone	74-92	mushroom body large-type Kenyon cell-specific protein 1	Bombyx mori	155-158
26363295-1	2015	20-hydroxyecdysone (20E)-induced expression of the wing disc cuticle protein gene BmWCP4 was mediated by the transcription factor BmPOUM2, which binds to the cis-response elements (CREs) of BmWCP4 gene in Bombyx mori.	Ecdysterone	0-18	Wcp7	Bombyx mori	61-76
26363295-1	2015	20-hydroxyecdysone (20E)-induced expression of the wing disc cuticle protein gene BmWCP4 was mediated by the transcription factor BmPOUM2, which binds to the cis-response elements (CREs) of BmWCP4 gene in Bombyx mori.	Ecdysterone	0-18	cuticular protein RR-2 motif 93	Bombyx mori	82-88
26363295-1	2015	20-hydroxyecdysone (20E)-induced expression of the wing disc cuticle protein gene BmWCP4 was mediated by the transcription factor BmPOUM2, which binds to the cis-response elements (CREs) of BmWCP4 gene in Bombyx mori.	Ecdysterone	0-18	silk gland factor 3	Bombyx mori	130-137
26363295-1	2015	20-hydroxyecdysone (20E)-induced expression of the wing disc cuticle protein gene BmWCP4 was mediated by the transcription factor BmPOUM2, which binds to the cis-response elements (CREs) of BmWCP4 gene in Bombyx mori.	Ecdysterone	0-18	cuticular protein RR-2 motif 93	Bombyx mori	190-196
26272745-0	2015	The Steroid Hormone 20-Hydroxyecdysone Up-regulates Ste-20 Family Serine/Threonine Kinase Hippo to Induce Programmed Cell Death.	Ecdysterone	20-38	serine/threonine kinase 24	Homo sapiens	52-58
26048653-3	2015	The aim of this study is to evaluate the hypothesis that the neuroprotective effects of phytoestrogen beta-ecdysterone (beta-Ecd) might mainly result from its antioxidant capability by the activation of the phosphoinositide-3-kinase (PI3K)-nuclear factor E2-related factor 2 (Nrf2)-regulated signaling pathway.	Ecdysterone	102-118	NFE2 like bZIP transcription factor 2	Rattus norvegicus	276-280
26048653-3	2015	The aim of this study is to evaluate the hypothesis that the neuroprotective effects of phytoestrogen beta-ecdysterone (beta-Ecd) might mainly result from its antioxidant capability by the activation of the phosphoinositide-3-kinase (PI3K)-nuclear factor E2-related factor 2 (Nrf2)-regulated signaling pathway.	Ecdysterone	120-128	NFE2 like bZIP transcription factor 2	Rattus norvegicus	276-280
26166384-0	2015	Bombyx E75 isoforms display stage- and tissue-specific responses to 20-hydroxyecdysone.	Ecdysterone	68-86	nuclear hormone receptor E75	Bombyx mori	7-10
25979705-3	2015	Loss of CTCF results in delayed and less synchronized larval development that can only be rescued by feeding larvae with both, the steroid hormone 20-hydroxyecdysone and cholesterol.	Ecdysterone	147-165	CTCF	Drosophila melanogaster	8-12
26126120-10	2015	The ApmVg transcript can be detected in the fat bodies of female pupae four days after treatment with 20-hydroxyecdysone and shows an expression pattern distinct from that of vitellogenin (Vg), which is detectable throughout diapausing and in post-diapause development.	Ecdysterone	102-120	vitellogenin	Bombyx mori	7-9
26060342-7	2015	Molecular docking experiments supported the ERbeta mediated action of ecdysterone.	Ecdysterone	70-81	estrogen receptor 2	Rattus norvegicus	44-50
26075272-3	2015	Here, we describe the ability of 20-hydroxyecdysone (1) and its mono- (2) and diacetonide (3) derivatives to sensitize various MDR and non-MDR cancer cell lines towards doxorubicin, paclitaxel, vincristine, or cisplatin.	Ecdysterone	33-51	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	127-130
25596092-6	2015	First, a small amount of 20-hydroxyecdysone was injected on day 4, two days before the expected day of the PTTH surge, to simulate the small rise in hemolymph ecdysteroid titer on day 5.	Ecdysterone	25-43	prothoracicotropic hormone	Bombyx mori	107-111
25617057-0	2015	Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1beta-induced catabolic gene expression in cartilage.	Ecdysterone	27-45	interleukin 1 beta	Mus musculus	58-66
26075272-3	2015	Here, we describe the ability of 20-hydroxyecdysone (1) and its mono- (2) and diacetonide (3) derivatives to sensitize various MDR and non-MDR cancer cell lines towards doxorubicin, paclitaxel, vincristine, or cisplatin.	Ecdysterone	33-51	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	139-142
25252945-4	2014	Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential expression of the nuclear receptors E75, DHR3 and betaFtz-f1, representing a model for steroid hormone signalling.	Ecdysterone	32-50	Ecdysone receptor	Drosophila melanogaster	69-72
25566327-8	2014	20-hydroxyecdysone (20E) application experiments revealed that low 20E levels induce EcR expression during development, whereas high ecdysteroid titers seem to be repressive.	Ecdysterone	0-18	ecdysone receptor	Apis mellifera	85-88
25213334-2	2014	In this study, we found that a partial TE (Taguchi) inserted in the cis-regulatory region of the silkworm ecdysone oxidase (EO) gene, which encodes a crucial enzyme to reduce the titer of molting hormone (20-hydroxyecdysone, 20E).	Ecdysterone	205-223	ecdysone oxidase	Bombyx mori	106-122
25213334-2	2014	In this study, we found that a partial TE (Taguchi) inserted in the cis-regulatory region of the silkworm ecdysone oxidase (EO) gene, which encodes a crucial enzyme to reduce the titer of molting hormone (20-hydroxyecdysone, 20E).	Ecdysterone	205-223	ecdysone oxidase	Bombyx mori	124-126
25240618-0	2014	Sumoylation modulates 20-hydroxyecdysone signaling by maintaining USP protein levels in Drosophila.	Ecdysterone	22-40	ultraspiracle	Drosophila melanogaster	66-69
25240618-1	2014	The nuclear receptor complex for the insect steroid hormone, 20-hydroxyecdysone (20E), is a heterodimer of EcR and USP.	Ecdysterone	61-79	Ecdysone receptor	Drosophila melanogaster	107-110
25240618-1	2014	The nuclear receptor complex for the insect steroid hormone, 20-hydroxyecdysone (20E), is a heterodimer of EcR and USP.	Ecdysterone	61-79	ultraspiracle	Drosophila melanogaster	115-118
25252945-4	2014	Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential expression of the nuclear receptors E75, DHR3 and betaFtz-f1, representing a model for steroid hormone signalling.	Ecdysterone	32-50	Ecdysone-induced protein 75B	Drosophila melanogaster	140-143
25252945-4	2014	Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential expression of the nuclear receptors E75, DHR3 and betaFtz-f1, representing a model for steroid hormone signalling.	Ecdysterone	32-50	Hormone receptor 3	Drosophila melanogaster	145-149
25252945-4	2014	Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential expression of the nuclear receptors E75, DHR3 and betaFtz-f1, representing a model for steroid hormone signalling.	Ecdysterone	32-50	ftz transcription factor 1	Drosophila melanogaster	154-164
24393712-3	2014	The 3.6-kb upstream promoter region of BmE74B was responsive to 20-hydroxyecdysone (20E) in a dose-dependent manner, and the highest luciferase activity was observed in the presence of 0.2 mug/ml 20E.	Ecdysterone	64-82	transcription factor E74	Bombyx mori	39-45
24727669-1	2014	In insects, a steroid hormone, 20-hydroxyecdysone (20E), plays important roles in the regulation of developmental transitions by initiating signaling cascades via the ecdysone receptor (EcR).	Ecdysterone	31-49	Ecdysone receptor	Drosophila melanogaster	167-184
24727669-1	2014	In insects, a steroid hormone, 20-hydroxyecdysone (20E), plays important roles in the regulation of developmental transitions by initiating signaling cascades via the ecdysone receptor (EcR).	Ecdysterone	31-49	Ecdysone receptor	Drosophila melanogaster	186-189
24945490-10	2014	Injection of 20-hydroxyecdysone (20E) into vvl knockdown larvae could restore the expression of HR3 although molting was never restored.	Ecdysterone	13-31	ventral vein lacking	Tribolium castaneum	43-46
24945490-10	2014	Injection of 20-hydroxyecdysone (20E) into vvl knockdown larvae could restore the expression of HR3 although molting was never restored.	Ecdysterone	13-31	probable nuclear hormone receptor HR3	Tribolium castaneum	96-99
24648308-0	2014	beta-Ecdysterone suppresses interleukin-1beta-induced apoptosis and inflammation in rat chondrocytes via inhibition of NF-kappaB signaling pathway.	Ecdysterone	0-16	interleukin 1 beta	Rattus norvegicus	28-45
24480536-6	2014	Moreover, EDS administration suppressed the ischemia stimulated activity of astrocytes and microglia cells by inhibiting the production of tumor necrosis alpha (TNF-alpha) in the brain of gerbil.	Ecdysterone	10-13	tumor necrosis factor	Homo sapiens	161-170
24373956-7	2014	Administration of high 20-hydroxyecdysone titers in the medium can also rescue the border cell migration phenotype in cultured egg chambers with an entirely phm mutant follicular epithelium.	Ecdysterone	23-41	phantom	Drosophila melanogaster	157-160
23811219-0	2013	20-Hydroxyecdysone-induced transcriptional activity of FoxO upregulates brummer and acid lipase-1 and promotes lipolysis in Bombyx fat body.	Ecdysterone	0-18	fkhr	Bombyx mori	55-59
24316411-0	2014	E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body.	Ecdysterone	29-47	Ecdysone-induced protein 93F	Drosophila melanogaster	0-3
24316411-2	2014	Both autophagy and caspase activity are induced by a pulse of molting hormone (20-hydroxyecdysone, 20E) via the 20E nuclear receptor complex, EcR-USP.	Ecdysterone	79-97	Ecdysone receptor	Drosophila melanogaster	142-145
25486781-1	2013	The expression of the DD2R gene was studied by in situ hybridization in the fat body (place of the synthesis of enzymes that degrade juvenile hormone) and ovarian follicular cells (place of the synthesis of 20-hydroxyecdysone) in young and sexually mature D. melanogaster females.	Ecdysterone	207-225	Dopamine 2-like receptor	Drosophila melanogaster	22-26
24036278-2	2013	Both autophagy and caspase activity progressively increase in the remodeling fat body, and they are induced by a pulse of the molting hormone (20-hydroxyecdysone, 20E) during the larval-prepupal transition.	Ecdysterone	143-161	Death caspase-1	Drosophila melanogaster	19-26
24023771-5	2013	A G-protein-coupled receptor (GPCR) binding to 20-hydroxyecdysone, the main insect steroid hormone, and dopamine, has been identified in Drosophila (DmDopEcR), and was suggested to modulate neuronal signaling.	Ecdysterone	47-65	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	149-157
23811219-0	2013	20-Hydroxyecdysone-induced transcriptional activity of FoxO upregulates brummer and acid lipase-1 and promotes lipolysis in Bombyx fat body.	Ecdysterone	0-18	lipase-1	Bombyx mori	89-97
23811219-1	2013	In a previous study, we have shown that the molting hormone, 20-hydroxyecdysone (20E), reduces insect food consumption resulting in fat body lipolysis during the non-feeding molting and pupation stages, and assumed that the transcription factor FoxO is involved in this process.	Ecdysterone	61-79	fkhr	Bombyx mori	245-249
23707601-11	2013	miR-281 expression was suppressed by 20-hydroxyecdysone treatments but not affected by juvenile hormone treatments.	Ecdysterone	37-55	microRNA 281	Bombyx mori	0-7
23397605-0	2013	20-Hydroxyecdysone-induced bone morphogenetic protein-2-dependent osteogenic differentiation through the ERK pathway in human periodontal ligament stem cells.	Ecdysterone	0-18	bone morphogenetic protein 2	Homo sapiens	27-55
23397605-0	2013	20-Hydroxyecdysone-induced bone morphogenetic protein-2-dependent osteogenic differentiation through the ERK pathway in human periodontal ligament stem cells.	Ecdysterone	0-18	mitogen-activated protein kinase 1	Homo sapiens	105-108
23397605-6	2013	20-Hydroxyecdysone promoted PDLS cell proliferation; significantly increased the gene expression levels of runt-related transcription factor 2, alkaline phosphatase (ALP), type I collagen, and osteocalcin.	Ecdysterone	0-18	RUNX family transcription factor 2	Homo sapiens	107-142
23397605-6	2013	20-Hydroxyecdysone promoted PDLS cell proliferation; significantly increased the gene expression levels of runt-related transcription factor 2, alkaline phosphatase (ALP), type I collagen, and osteocalcin.	Ecdysterone	0-18	alkaline phosphatase, placental	Homo sapiens	144-164
23397605-6	2013	20-Hydroxyecdysone promoted PDLS cell proliferation; significantly increased the gene expression levels of runt-related transcription factor 2, alkaline phosphatase (ALP), type I collagen, and osteocalcin.	Ecdysterone	0-18	alkaline phosphatase, placental	Homo sapiens	166-169
23397605-6	2013	20-Hydroxyecdysone promoted PDLS cell proliferation; significantly increased the gene expression levels of runt-related transcription factor 2, alkaline phosphatase (ALP), type I collagen, and osteocalcin.	Ecdysterone	0-18	bone gamma-carboxyglutamate protein	Homo sapiens	172-204
23397605-7	2013	Moreover, 20-Hydroxyecdysone enhanced bone formation by PDLS cells and significantly increased bone morphogenetic protein-2 (BMP-2) mRNA and protein expression.	Ecdysterone	10-28	bone morphogenetic protein 2	Homo sapiens	95-123
23397605-7	2013	Moreover, 20-Hydroxyecdysone enhanced bone formation by PDLS cells and significantly increased bone morphogenetic protein-2 (BMP-2) mRNA and protein expression.	Ecdysterone	10-28	bone morphogenetic protein 2	Homo sapiens	125-130
23397605-9	2013	20-Hydroxyecdysone also increased the phosphorylation of ERK.	Ecdysterone	0-18	mitogen-activated protein kinase 1	Homo sapiens	57-60
23397605-10	2013	These findings provide evidence to state that 20-Hydroxyecdysone stimulates cell proliferation and induces osteogenic differentiation through the induction of BMP-2 expression in PDLS cells.	Ecdysterone	46-64	bone morphogenetic protein 2	Homo sapiens	159-164
23397605-11	2013	It also shows that the ERK pathway is involved in 20-Hydroxyecdysone induced BMP-2 expression and osteogenic differentiation.	Ecdysterone	50-68	mitogen-activated protein kinase 1	Homo sapiens	23-26
23397605-11	2013	It also shows that the ERK pathway is involved in 20-Hydroxyecdysone induced BMP-2 expression and osteogenic differentiation.	Ecdysterone	50-68	bone morphogenetic protein 2	Homo sapiens	77-82
22858168-0	2012	20-Hydroxyecdysone attenuates TGF-beta1-induced renal cellular fibrosis in proximal tubule cells.	Ecdysterone	0-18	transforming growth factor beta 1	Homo sapiens	30-39
23136906-0	2012	PKC-mediated USP phosphorylation at Ser35 modulates 20-hydroxyecdysone signaling in Drosophila.	Ecdysterone	52-70	Protein C kinase 53E	Drosophila melanogaster	0-3
23136906-0	2012	PKC-mediated USP phosphorylation at Ser35 modulates 20-hydroxyecdysone signaling in Drosophila.	Ecdysterone	52-70	ultraspiracle	Drosophila melanogaster	13-16
23136906-1	2012	The nuclear receptor complex of the steroid hormone, 20-hydroxyecdysone (20E), is a heterodimer composed of EcR and USP.	Ecdysterone	53-71	Ecdysone receptor	Drosophila melanogaster	108-111
23136906-1	2012	The nuclear receptor complex of the steroid hormone, 20-hydroxyecdysone (20E), is a heterodimer composed of EcR and USP.	Ecdysterone	53-71	ultraspiracle	Drosophila melanogaster	116-119
22310011-1	2012	The steroid hormone 20-hydroxyecdysone and its EcR/USP receptor are vital during arthropod development for coordinating molting and metamorphosis.	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	47-50
22668504-5	2012	Moreover, we isolated and identified 20-hydroxyecdysone (20-HES) as a marker component in FAJN.	Ecdysterone	37-55	ribosome binding protein 1	Homo sapiens	60-63
22623504-3	2012	In this study, the expression levels of seven commonly used reference genes (ACT, GAPDH, 28srRNA, RPL3, alpha-tubulin, UBC, and TBP) were detected at different development time points and in response to treatment with 20-hydroxyecdysone (20E) and with rutin.	Ecdysterone	218-236	glyceraldehyde-3-phosphate dehydrogenase	Bombyx mori	82-87
22623504-3	2012	In this study, the expression levels of seven commonly used reference genes (ACT, GAPDH, 28srRNA, RPL3, alpha-tubulin, UBC, and TBP) were detected at different development time points and in response to treatment with 20-hydroxyecdysone (20E) and with rutin.	Ecdysterone	218-236	ribosomal protein L3	Bombyx mori	98-102
22623504-3	2012	In this study, the expression levels of seven commonly used reference genes (ACT, GAPDH, 28srRNA, RPL3, alpha-tubulin, UBC, and TBP) were detected at different development time points and in response to treatment with 20-hydroxyecdysone (20E) and with rutin.	Ecdysterone	218-236	TATA-box-binding protein	Bombyx mori	128-131
22510985-2	2012	In this study, we show that the Drosophila steroid hormone 20-hydroxyecdysone (20E) and its nuclear receptor directly activate transcription of the evolutionarily conserved let-7-complex (let-7-C) locus, which encodes the co-transcribed microRNAs miR-100, let-7 and miR-125.	Ecdysterone	59-77	let-7	Drosophila melanogaster	173-178
22510985-2	2012	In this study, we show that the Drosophila steroid hormone 20-hydroxyecdysone (20E) and its nuclear receptor directly activate transcription of the evolutionarily conserved let-7-complex (let-7-C) locus, which encodes the co-transcribed microRNAs miR-100, let-7 and miR-125.	Ecdysterone	59-77	let-7	Drosophila melanogaster	188-193
22510985-2	2012	In this study, we show that the Drosophila steroid hormone 20-hydroxyecdysone (20E) and its nuclear receptor directly activate transcription of the evolutionarily conserved let-7-complex (let-7-C) locus, which encodes the co-transcribed microRNAs miR-100, let-7 and miR-125.	Ecdysterone	59-77	mir-100 stem loop	Drosophila melanogaster	247-254
22510985-2	2012	In this study, we show that the Drosophila steroid hormone 20-hydroxyecdysone (20E) and its nuclear receptor directly activate transcription of the evolutionarily conserved let-7-complex (let-7-C) locus, which encodes the co-transcribed microRNAs miR-100, let-7 and miR-125.	Ecdysterone	59-77	let-7	Drosophila melanogaster	188-193
22510985-2	2012	In this study, we show that the Drosophila steroid hormone 20-hydroxyecdysone (20E) and its nuclear receptor directly activate transcription of the evolutionarily conserved let-7-complex (let-7-C) locus, which encodes the co-transcribed microRNAs miR-100, let-7 and miR-125.	Ecdysterone	59-77	mir-125 stem loop	Drosophila melanogaster	266-273
22559968-2	2012	The active metabolite of ecdysone, 20-hydroxyecdysone (20E), works through ecdysone receptor (EcR) and ultraspiracle (USP) to initiate molting and metamorphosis by regulating downstream genes.	Ecdysterone	35-53	ecdysone receptor	Bombyx mori	75-92
22559968-2	2012	The active metabolite of ecdysone, 20-hydroxyecdysone (20E), works through ecdysone receptor (EcR) and ultraspiracle (USP) to initiate molting and metamorphosis by regulating downstream genes.	Ecdysterone	35-53	ecdysone receptor	Bombyx mori	94-97
22559968-2	2012	The active metabolite of ecdysone, 20-hydroxyecdysone (20E), works through ecdysone receptor (EcR) and ultraspiracle (USP) to initiate molting and metamorphosis by regulating downstream genes.	Ecdysterone	35-53	protein ultraspiracle homolog	Bombyx mori	118-121
22882178-7	2012	The steroid hormone 20-hydroxyecdysone is able to promote the transformation of granulocytes into macrogranulocytes, and up-regulate the expression level of cathepsin L.	Ecdysterone	20-38	cathepsin L	Mus musculus	157-168
22828514-7	2012	These results suggest that the EcREs are vital for activation of the promoter by 20-hydroxyecdysone (20E) in the larval fat body and further support the crucial role of ecdysone signaling to control cathepsin D gene transcription.	Ecdysterone	81-99	cathepsin D	Bombyx mori	199-210
22484004-3	2012	Administration of 20-OH-ecdysone showed significant increase in the levels of glycolytic enzyme (hexokinase) and hepatic shunt enzyme (glucose-6-phosphate dehydrogenase) whereas significant decrease in the levels of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) in diabetic treated rats.	Ecdysterone	18-32	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	239-260
22310011-1	2012	The steroid hormone 20-hydroxyecdysone and its EcR/USP receptor are vital during arthropod development for coordinating molting and metamorphosis.	Ecdysterone	20-38	ultraspiracle	Drosophila melanogaster	51-54
22574182-5	2012	A Cyp301a1 piggyBac insertion mutant and RNAi of Cyp301a1 both show a similar cuticle malformation phenotype, which can be reduced by 20-hydroxyecdysone, suggesting that Cyp301a1 is an important gene involved in the formation of the adult cuticle and may be involved in ecdysone regulation in this tissue.	Ecdysterone	134-152	Cyp301a1	Drosophila melanogaster	2-10
23226617-4	2012	Furthermore, DREF knockdown in the prothoracic gland of larva prevented pupation and this was rescued via 20-hydroxyecdysone treatment.	Ecdysterone	106-124	DNA replication-related element factor	Drosophila melanogaster	13-17
22574182-5	2012	A Cyp301a1 piggyBac insertion mutant and RNAi of Cyp301a1 both show a similar cuticle malformation phenotype, which can be reduced by 20-hydroxyecdysone, suggesting that Cyp301a1 is an important gene involved in the formation of the adult cuticle and may be involved in ecdysone regulation in this tissue.	Ecdysterone	134-152	Cyp301a1	Drosophila melanogaster	49-57
22574182-5	2012	A Cyp301a1 piggyBac insertion mutant and RNAi of Cyp301a1 both show a similar cuticle malformation phenotype, which can be reduced by 20-hydroxyecdysone, suggesting that Cyp301a1 is an important gene involved in the formation of the adult cuticle and may be involved in ecdysone regulation in this tissue.	Ecdysterone	134-152	Cyp301a1	Drosophila melanogaster	49-57
22500399-0	2012	[Effects of ecdysterone on the expression of NF-kappaB p65 in H2O2 induced oxidative damage of human lens epithelial cells].	Ecdysterone	12-23	nuclear factor kappa B subunit 1	Homo sapiens	45-54
22500399-0	2012	[Effects of ecdysterone on the expression of NF-kappaB p65 in H2O2 induced oxidative damage of human lens epithelial cells].	Ecdysterone	12-23	RELA proto-oncogene, NF-kB subunit	Homo sapiens	55-58
22500399-1	2012	OBJECTIVE: To study the effects of ecdysterone (ECR) on the expression of nuclear factor (NF)-kappaB in H2O2 induced oxidative damage of human lens epithelial cells (HLECs).	Ecdysterone	35-46	nuclear factor kappa B subunit 1	Homo sapiens	74-100
21900267-1	2011	The steroid hormone 20-hydroxyecdysone (20E) regulates gene transcription through the heterodimeric nuclear receptor composed of ecdysone receptor (EcR) and Ultraspiracle (USP).	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	129-146
21968404-6	2011	Expression of Kr-h1, a JH response gene that inhibits 20-hydroxyecdysone (20E)-induced broad (br) expression, is abolished in Met(27) gce(2.5k) during larval molts.	Ecdysterone	54-72	Kruppel homolog 1	Drosophila melanogaster	14-19
21968404-6	2011	Expression of Kr-h1, a JH response gene that inhibits 20-hydroxyecdysone (20E)-induced broad (br) expression, is abolished in Met(27) gce(2.5k) during larval molts.	Ecdysterone	54-72	Methoprene-tolerant	Drosophila melanogaster	126-129
21900267-1	2011	The steroid hormone 20-hydroxyecdysone (20E) regulates gene transcription through the heterodimeric nuclear receptor composed of ecdysone receptor (EcR) and Ultraspiracle (USP).	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	148-151
21900267-1	2011	The steroid hormone 20-hydroxyecdysone (20E) regulates gene transcription through the heterodimeric nuclear receptor composed of ecdysone receptor (EcR) and Ultraspiracle (USP).	Ecdysterone	20-38	ultraspiracle	Drosophila melanogaster	172-175
21928393-0	2011	Increased levels of the cell cycle inhibitor protein, dacapo, accompany 20-hydroxyecdysone-induced G1 arrest in a mosquito cell line.	Ecdysterone	72-90	dacapo	Drosophila melanogaster	54-60
21769927-4	2011	Correlation of ALP activity and mRNA levels at different developmental stages, or following application of 20-hydroxyecdysone (20E) and insecticide fenvalerate, suggests that Nl-ALP1 and Nl-ALP2 might encode a soluble (sALP) and a membrane-bound ALP (mALP), respectively.	Ecdysterone	107-125	alopecia, recessive	Mus musculus	15-18
21769927-4	2011	Correlation of ALP activity and mRNA levels at different developmental stages, or following application of 20-hydroxyecdysone (20E) and insecticide fenvalerate, suggests that Nl-ALP1 and Nl-ALP2 might encode a soluble (sALP) and a membrane-bound ALP (mALP), respectively.	Ecdysterone	107-125	alopecia, recessive	Mus musculus	178-181
21763268-3	2011	26-Hydroxylation of the insect steroid hormone 20-hydroxyecdysone by a microsomal cytochrome P450 was previously found to be responsible for hormonal resistance in a Chironomus cell line mainly producing the (25S)-epimer of 20,26-dihydroxyecdysone.	Ecdysterone	47-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	82-97
21277979-2	2011	We show here that the expression of neverland and Non-molting glossy/shroud, which are involved in early steps of ecdysteroid synthesis, was enhanced in the ovary, while the expression of CYP306A1 and CYP302A1, which are involved in later steps of ecdysone synthesis, was enhanced in the brain, and the expression of CYP314A1, which is involved in converting ecdysone into active 20-hydroxyecdysone (20E), was enhanced in the brain, fat body, and ovary.	Ecdysterone	380-398	cytochrome P450 306a1	Apis mellifera	188-196
21671917-4	2011	The results showed that the Blimp-1 gene is transcribed in cultured organs taken from a low ecdysteroid period even after extended exposure to 20-hydroxyecdysone, while well-known early genes such as E75A are repressed under the same conditions.	Ecdysterone	143-161	Blimp-1	Drosophila melanogaster	28-35
21627452-6	2011	Adding 20-hydroxyecdysone or its analog, tebufenozide to cultured fat bodies increased beta-galactosidase activity in these tissues.	Ecdysterone	7-25	beta-galactosidase	Bombyx mori	87-105
21627452-7	2011	Therefore, 20-hydroxyecdysone may induce a structural change in Sialyl Lewis x type sugar chains on the cell surface of silkworm"s organs by increasing the beta-galactosidase activity to detach hemocytes from organs and increase the number of circulating hemocytes during the larval-larval molting period.	Ecdysterone	11-29	beta-galactosidase	Bombyx mori	156-174
21277979-2	2011	We show here that the expression of neverland and Non-molting glossy/shroud, which are involved in early steps of ecdysteroid synthesis, was enhanced in the ovary, while the expression of CYP306A1 and CYP302A1, which are involved in later steps of ecdysone synthesis, was enhanced in the brain, and the expression of CYP314A1, which is involved in converting ecdysone into active 20-hydroxyecdysone (20E), was enhanced in the brain, fat body, and ovary.	Ecdysterone	380-398	cytochrome P450 302a1, mitochondrial	Apis mellifera	201-209
21277979-2	2011	We show here that the expression of neverland and Non-molting glossy/shroud, which are involved in early steps of ecdysteroid synthesis, was enhanced in the ovary, while the expression of CYP306A1 and CYP302A1, which are involved in later steps of ecdysone synthesis, was enhanced in the brain, and the expression of CYP314A1, which is involved in converting ecdysone into active 20-hydroxyecdysone (20E), was enhanced in the brain, fat body, and ovary.	Ecdysterone	380-398	cytochrome P450 314A1	Apis mellifera	317-325
20932968-5	2011	When Cyp18a1 is transfected in Drosophila S2 cells, extensive conversion of 20-hydroxyecdysone (20E) into 20-hydroxyecdysonoic acid is observed.	Ecdysterone	76-94	Cytochrome P450-18a1	Drosophila melanogaster	5-12
20609020-6	2010	Furthermore, both BmTor genes were up-regulated by either starvation or the moulting hormone 20-hydroxyecdysone (20E), while BmTor2 was more sensitive to both treatments than BmTor1.	Ecdysterone	93-111	target of rapamycin isoform 2	Bombyx mori	125-131
22087234-3	2011	Until recent years, increasing evidence has suggested that JH modulates the action of 20-hydroxyecdysone (20E) by regulating expression of broad (br), a 20E early response gene, through Met/Gce and Kr-h1.	Ecdysterone	86-104	Kruppel homolog 1	Drosophila melanogaster	198-203
20872795-7	2010	In addition, 20-Hydroxyecdysone dramatically reduced the CoCl(2)-induced production of reactive oxygen species (ROS), decreased the depolarization of the mitochondrial membrane, inhibited the release of cytochrome c into the cytosol and increased the Bax/Bcl-2 ratio.	Ecdysterone	13-31	BCL2 associated X, apoptosis regulator	Rattus norvegicus	251-254
20872795-7	2010	In addition, 20-Hydroxyecdysone dramatically reduced the CoCl(2)-induced production of reactive oxygen species (ROS), decreased the depolarization of the mitochondrial membrane, inhibited the release of cytochrome c into the cytosol and increased the Bax/Bcl-2 ratio.	Ecdysterone	13-31	BCL2, apoptosis regulator	Rattus norvegicus	255-260
20872795-8	2010	Furthermore, 20-Hydroxyecdysone eliminated the CoCl(2)-induced activation of caspase-3.	Ecdysterone	13-31	caspase 3	Rattus norvegicus	77-86
20817116-1	2010	In holometabolous insects, the steroid hormone 20-hydroxyecdysone (20E), in coordination with juvenile hormone, regulates the major developmental events that promote larval development and the transition from the larval to the pupal stage.	Ecdysterone	47-65	Partner of Bursicon	Drosophila melanogaster	227-232
20609020-6	2010	Furthermore, both BmTor genes were up-regulated by either starvation or the moulting hormone 20-hydroxyecdysone (20E), while BmTor2 was more sensitive to both treatments than BmTor1.	Ecdysterone	93-111	target of rapamycin isoform 1	Bombyx mori	175-181
20197069-4	2010	Developmental profile studies revealed that the expression levels of InR, IRS, PI3K110, and PDK were elevated in the fat body during molting and pupation, periods when animals ceased feeding and hemolymph levels of 20-hydroxyecdysone (20E) were high.	Ecdysterone	215-233	insulin receptor	Bombyx mori	69-72
20803583-0	2010	Sox14 is required for transcriptional and developmental responses to 20-hydroxyecdysone at the onset of drosophila metamorphosis.	Ecdysterone	69-87	Sox box protein 14	Drosophila melanogaster	0-5
20803583-1	2010	The steroid hormone 20-hydroxyecdysone (20E), by means of a heterodimer consisting of two nuclear receptors, the Ecdysone receptor (EcR) and Ultraspiracle (Usp), triggers the major developmental transitions in the Drosophila life cycle through the regulation of genetic hierarchies.	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	113-130
20803583-1	2010	The steroid hormone 20-hydroxyecdysone (20E), by means of a heterodimer consisting of two nuclear receptors, the Ecdysone receptor (EcR) and Ultraspiracle (Usp), triggers the major developmental transitions in the Drosophila life cycle through the regulation of genetic hierarchies.	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	132-135
20803583-1	2010	The steroid hormone 20-hydroxyecdysone (20E), by means of a heterodimer consisting of two nuclear receptors, the Ecdysone receptor (EcR) and Ultraspiracle (Usp), triggers the major developmental transitions in the Drosophila life cycle through the regulation of genetic hierarchies.	Ecdysterone	20-38	ultraspiracle	Drosophila melanogaster	156-159
20816850-7	2010	After diapause is broken by injection of 20-hydroxyecdysone, expression of Hea-cox1 mRNA and protein increases gradually and COX activity increases significantly.	Ecdysterone	41-59	cytochrome c oxidase subunit I	Helicoverpa armigera	79-83
20672340-2	2010	These DAHs have been shown to manifest their toxicity via interaction with the ecdysone receptor (EcR) in susceptible insects, as does the natural insect moulting hormone 20-hydroxyecdysone (20E).	Ecdysterone	171-189	ecdysone receptor	Bombyx mori	79-96
20798594-5	2010	Here we used Drosophila S2 cells to analyze the effects of 20-HE on D. melanogaster microRNA let-7 and miR-125, the homolog of lin-4.	Ecdysterone	59-64	let-7	Drosophila melanogaster	93-98
20798594-5	2010	Here we used Drosophila S2 cells to analyze the effects of 20-HE on D. melanogaster microRNA let-7 and miR-125, the homolog of lin-4.	Ecdysterone	59-64	lin-4	Caenorhabditis elegans	127-132
20798594-6	2010	The induction by 20-HE of let-7 and miR-125 in S2 cells is inhibited by RNAi knockdown of the ecdysone receptor and, as previously shown, by knockdown of its cofactor broad-complex C. To help resolve the currently ambiguous role of 20-HE in the control of microRNA, we show that nanomolar concentrations of 20-HE primes cells to subsequently express microRNA when exposed to micromolar levels of 20-HE.	Ecdysterone	17-22	let-7	Drosophila melanogaster	26-31
20798594-6	2010	The induction by 20-HE of let-7 and miR-125 in S2 cells is inhibited by RNAi knockdown of the ecdysone receptor and, as previously shown, by knockdown of its cofactor broad-complex C. To help resolve the currently ambiguous role of 20-HE in the control of microRNA, we show that nanomolar concentrations of 20-HE primes cells to subsequently express microRNA when exposed to micromolar levels of 20-HE.	Ecdysterone	17-22	mir-125 stem loop	Drosophila melanogaster	36-43
20197069-4	2010	Developmental profile studies revealed that the expression levels of InR, IRS, PI3K110, and PDK were elevated in the fat body during molting and pupation, periods when animals ceased feeding and hemolymph levels of 20-hydroxyecdysone (20E) were high.	Ecdysterone	215-233	pyruvate dehydrogenase kinase	Bombyx mori	92-95
20363237-3	2010	In this study we show that in a mouse skeletal muscle cell line, C(2)C(12), 20-hydroxyecdysone (20HE), a common phytoecdysteroid in both insects and plants, elicited a rapid elevation in intracellular calcium, followed by sustained Akt activation and increased protein synthesis.	Ecdysterone	76-94	thymoma viral proto-oncogene 1	Mus musculus	232-235
20363237-3	2010	In this study we show that in a mouse skeletal muscle cell line, C(2)C(12), 20-hydroxyecdysone (20HE), a common phytoecdysteroid in both insects and plants, elicited a rapid elevation in intracellular calcium, followed by sustained Akt activation and increased protein synthesis.	Ecdysterone	96-100	thymoma viral proto-oncogene 1	Mus musculus	232-235
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysterone	131-149	Ecdysone receptor	Drosophila melanogaster	173-190
19631716-13	2010	HR3 levels were significantly induced by 20-hydroxyecdysone; while E75 levels were minimally affected.	Ecdysterone	41-59	Hormone receptor 3	Drosophila melanogaster	0-3
20023167-6	2010	We show that mid-embryonic expression of DHR3 and betaFTZ-F1 is part of a 20-hydroxyecdysone (20E)-triggered transcriptional cascade similar to that seen in mid-prepupae, directing maximal expression of E74A and E75A during late embryogenesis.	Ecdysterone	74-92	Hormone receptor 3	Drosophila melanogaster	41-45
20023167-6	2010	We show that mid-embryonic expression of DHR3 and betaFTZ-F1 is part of a 20-hydroxyecdysone (20E)-triggered transcriptional cascade similar to that seen in mid-prepupae, directing maximal expression of E74A and E75A during late embryogenesis.	Ecdysterone	74-92	ftz transcription factor 1	Drosophila melanogaster	50-60
20023167-6	2010	We show that mid-embryonic expression of DHR3 and betaFTZ-F1 is part of a 20-hydroxyecdysone (20E)-triggered transcriptional cascade similar to that seen in mid-prepupae, directing maximal expression of E74A and E75A during late embryogenesis.	Ecdysterone	74-92	Ecdysone-induced protein 74EF	Drosophila melanogaster	203-207
20023167-6	2010	We show that mid-embryonic expression of DHR3 and betaFTZ-F1 is part of a 20-hydroxyecdysone (20E)-triggered transcriptional cascade similar to that seen in mid-prepupae, directing maximal expression of E74A and E75A during late embryogenesis.	Ecdysterone	74-92	Ecdysone-induced protein 75B	Drosophila melanogaster	212-216
19802901-0	2009	20-hydroxyecdysone and juvenile hormone influence tyrosine hydroxylase activity in Drosophila females under normal and heat stress conditions.	Ecdysterone	0-18	pale	Drosophila melanogaster	50-70
19802901-1	2009	The effects of exogenous 20-hydroxyecdysone (20E) and the juvenile hormone (JH) on the activity of the tyrosine hydroxylase (TH), the first and rate-limiting DA biosynthetic enzyme, has been studied in young females of wild type D. virilis and D. melanogaster under normal conditions and under heat stress (38 degrees C).	Ecdysterone	25-43	pale	Drosophila melanogaster	103-123
19754738-3	2009	Deletion analysis in Drosophila melanogaster mbn2 (mbn2) cells identified a cis-regulatory element (AAGAAAGATCCCCTG) necessary for 20-hydroxyecdysone enhancement of peptidoglycan-induced expression of diptericin in the 3 kb diptericin promoter.	Ecdysterone	131-149	Diptericin A	Drosophila melanogaster	201-211
19754738-3	2009	Deletion analysis in Drosophila melanogaster mbn2 (mbn2) cells identified a cis-regulatory element (AAGAAAGATCCCCTG) necessary for 20-hydroxyecdysone enhancement of peptidoglycan-induced expression of diptericin in the 3 kb diptericin promoter.	Ecdysterone	131-149	Diptericin A	Drosophila melanogaster	224-234
19754738-5	2009	20-hydroxyecdysone also enhanced peptidoglycan-induced expression of four other antimicrobial peptide (AMP) genes--drosomycin, attacin-A, metchnikowin and cecropin A1.	Ecdysterone	0-18	Drosomycin	Drosophila melanogaster	115-125
19754738-5	2009	20-hydroxyecdysone also enhanced peptidoglycan-induced expression of four other antimicrobial peptide (AMP) genes--drosomycin, attacin-A, metchnikowin and cecropin A1.	Ecdysterone	0-18	Attacin-A	Drosophila melanogaster	127-136
19754738-5	2009	20-hydroxyecdysone also enhanced peptidoglycan-induced expression of four other antimicrobial peptide (AMP) genes--drosomycin, attacin-A, metchnikowin and cecropin A1.	Ecdysterone	0-18	Cecropin A1	Drosophila melanogaster	155-166
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysterone	131-149	Ecdysone receptor	Drosophila melanogaster	231-234
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysterone	131-149	Ecdysone receptor	Drosophila melanogaster	249-254
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysterone	131-149	Ecdysone receptor	Drosophila melanogaster	256-262
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysterone	131-149	Ecdysone receptor	Drosophila melanogaster	249-252
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysterone	131-149	ultraspiracle	Drosophila melanogaster	294-297
19072925-4	2009	When compared to the control insects undergoing larval-pupal molt, down-regulation of expression of transcription factor, Broad, and up-regulation of other genes involved in 20-hydroxyecdysone (20E) action (FTZ-F1, E74) were observed in JHA-treated larvae undergoing supernumerary larval molts.	Ecdysterone	174-192	nuclear hormone receptor FTZ-F1	Tribolium castaneum	207-213
19268446-1	2009	In insects, 20-hydroxyecdysone acts by binding on a heterodimer constituted by the ecdysone receptor (EcR) and Ultraspiracle (USP), the homolog to the vertebrate retinoid X receptor (RXR).	Ecdysterone	12-30	Ecdysone receptor	Drosophila melanogaster	83-100
19268446-1	2009	In insects, 20-hydroxyecdysone acts by binding on a heterodimer constituted by the ecdysone receptor (EcR) and Ultraspiracle (USP), the homolog to the vertebrate retinoid X receptor (RXR).	Ecdysterone	12-30	Ecdysone receptor	Drosophila melanogaster	102-105
19268446-1	2009	In insects, 20-hydroxyecdysone acts by binding on a heterodimer constituted by the ecdysone receptor (EcR) and Ultraspiracle (USP), the homolog to the vertebrate retinoid X receptor (RXR).	Ecdysterone	12-30	ultraspiracle	Drosophila melanogaster	126-129
19237466-1	2009	We determined the physical locations of the heterodimeric Ecdysone receptor/Ultraspiracle (ECR/USP) nuclear hormone receptor complex throughout the entire nonrepetitive genome of Drosophila melanogaster using a cell line (Kc167) that differentiates in response to 20-hydroxyecdysone (20-HE).	Ecdysterone	264-282	Ecdysone receptor	Drosophila melanogaster	58-98
19237466-1	2009	We determined the physical locations of the heterodimeric Ecdysone receptor/Ultraspiracle (ECR/USP) nuclear hormone receptor complex throughout the entire nonrepetitive genome of Drosophila melanogaster using a cell line (Kc167) that differentiates in response to 20-hydroxyecdysone (20-HE).	Ecdysterone	284-289	Ecdysone receptor	Drosophila melanogaster	58-98
19278013-1	2009	The effect of exogenous 20-hydroxyecdysone (20E) and juvenile hormone (JH) on the activities of the tyrosine decarboxylase (TDC), the first enzyme in octopamine (OA) synthesis, has been studied in young females of wild type D. virilis and D. melanogaster under normal and heat stress (38 degrees C) conditions.	Ecdysterone	24-42	Tyrosine decarboxylase 1	Drosophila melanogaster	124-127
19580867-3	2009	The promoter activity of BMWCP10 was responsive to 20-hydroxyecdysone (20E) in a dose-dependent manner, and the highest luciferase activity was observed in the presence of 2 microg/ml 20E.	Ecdysterone	51-69	cuticular protein RR-1 motif 21	Bombyx mori	25-32
19465595-3	2009	In the fat body of the JH-deficient animals, Dronc and Drice, two caspase genes that are crucial for PCD induced by the molting hormone 20-hydroxyecdysone (20E), were significantly upregulated.	Ecdysterone	136-154	Death regulator Nedd2-like caspase	Drosophila melanogaster	45-50
19465595-3	2009	In the fat body of the JH-deficient animals, Dronc and Drice, two caspase genes that are crucial for PCD induced by the molting hormone 20-hydroxyecdysone (20E), were significantly upregulated.	Ecdysterone	136-154	Death related ICE-like caspase	Drosophila melanogaster	55-60
19162019-4	2009	In S2 cells, the stable overexpression of Dm_MSBP suppressed the growth arrest triggered by 20-hydroxyecdysone and prevented the temporal activation of extracellular signal-regulated kinase proteins.	Ecdysterone	92-110	membrane steroid binding protein	Drosophila melanogaster	42-49
18038140-1	2008	The effect of 20-hydroxyecdysone (20E) and the juvenile hormone (JH) on the activity of the arylalkylamine N-acetyltransferase (AANAT) was studied in young females of wild-type D. virilis and D. melanogaster.	Ecdysterone	14-32	Arylalkylamine N-acetyltransferase 1	Drosophila melanogaster	92-126
19133079-9	2008	Salivary gland culture experiments showed that the Cchsp27 gene is regulated by 20-hydroxyecdysone.	Ecdysterone	80-98	heat shock protein 27	Ceratitis capitata	51-58
18353099-8	2008	Eip63F-1 is one of many genes controlled by the steroid hormone 20-hydroxyecdysone that appear to be co-regulated by Fkh.	Ecdysterone	64-82	Ecdysone-induced protein 63F 1	Drosophila melanogaster	0-8
18353099-8	2008	Eip63F-1 is one of many genes controlled by the steroid hormone 20-hydroxyecdysone that appear to be co-regulated by Fkh.	Ecdysterone	64-82	fork head	Drosophila melanogaster	117-120
18038140-1	2008	The effect of 20-hydroxyecdysone (20E) and the juvenile hormone (JH) on the activity of the arylalkylamine N-acetyltransferase (AANAT) was studied in young females of wild-type D. virilis and D. melanogaster.	Ecdysterone	14-32	Arylalkylamine N-acetyltransferase 1	Drosophila melanogaster	128-133
17703313-6	2008	We discuss the supposition that ecdysone 20-monooxygenase occupies a key position in the regulation of 20-hydroxyecdysone titre under the conditions that lead to changes in juvenile hormone titre and biogenic amine levels.	Ecdysterone	103-121	shade	Drosophila melanogaster	32-57
18256476-7	2008	DmST4 also showed low but not negligible activity toward 20-hydroxyecdysone.	Ecdysterone	57-75	Sulfotransferase 4	Drosophila melanogaster	0-5
17703313-0	2008	Role of ecdysone 20-monooxygenase in regulation of 20-hydroxyecdysone levels by juvenile hormone and biogenic amines in Drosophila.	Ecdysterone	51-69	shade	Drosophila melanogaster	8-33
17923694-5	2007	Drosophila Blimp-1 (dBlimp-1) is induced directly by 20-hydroxyecdysone, and its product exists during high-ecdysteroid periods and turns over rapidly.	Ecdysterone	53-71	Blimp-1	Drosophila melanogaster	11-18
17967346-8	2007	By injecting 20-hydroxyecdysone (20E) in early pupae we demonstrated that hormone titer decay after the peak is critical for AmelCPR14 expression induction.	Ecdysterone	13-31	cuticular protein 14	Apis mellifera	125-134
17923694-5	2007	Drosophila Blimp-1 (dBlimp-1) is induced directly by 20-hydroxyecdysone, and its product exists during high-ecdysteroid periods and turns over rapidly.	Ecdysterone	53-71	Blimp-1	Drosophila melanogaster	20-28
17924685-1	2007	Ecdysone receptor (EcR) and its heterodimeric partner, ultraspiracle protein (USP), are nuclear receptors that mediate the action of the insect molting hormone 20-hydroxyecdysone (20E).	Ecdysterone	160-178	ultraspiracle	Drosophila melanogaster	78-81
17658648-2	2007	A transient expression experiment using BmN cells and a series of truncated ie1 promoter constructs demonstrated that the activity of the ie1 promoter responded to alpha-ecdysone and 20-hydroxyecdysone, which required a tridecameric nucleotide stretch (ie1EcRE, 5"-GTGTTATCGACCT-3") homologous to the ecdysone response element reported for Drosophila (DmEcRE).	Ecdysterone	183-201	integument esterase 1	Bombyx mori	76-79
17658648-2	2007	A transient expression experiment using BmN cells and a series of truncated ie1 promoter constructs demonstrated that the activity of the ie1 promoter responded to alpha-ecdysone and 20-hydroxyecdysone, which required a tridecameric nucleotide stretch (ie1EcRE, 5"-GTGTTATCGACCT-3") homologous to the ecdysone response element reported for Drosophila (DmEcRE).	Ecdysterone	183-201	integument esterase 1	Bombyx mori	138-141
17924685-1	2007	Ecdysone receptor (EcR) and its heterodimeric partner, ultraspiracle protein (USP), are nuclear receptors that mediate the action of the insect molting hormone 20-hydroxyecdysone (20E).	Ecdysterone	160-178	Ecdysone receptor	Drosophila melanogaster	0-17
17804599-2	2007	npc1a, the Drosophila NPC1 ortholog, regulates sterol homeostasis and is essential for molting hormone (20-hydroxyecdysone; 20E) biosynthesis.	Ecdysterone	104-122	Niemann-Pick type C-1a	Drosophila melanogaster	0-5
17924685-1	2007	Ecdysone receptor (EcR) and its heterodimeric partner, ultraspiracle protein (USP), are nuclear receptors that mediate the action of the insect molting hormone 20-hydroxyecdysone (20E).	Ecdysterone	160-178	Ecdysone receptor	Drosophila melanogaster	19-22
17924685-1	2007	Ecdysone receptor (EcR) and its heterodimeric partner, ultraspiracle protein (USP), are nuclear receptors that mediate the action of the insect molting hormone 20-hydroxyecdysone (20E).	Ecdysterone	160-178	ultraspiracle	Drosophila melanogaster	55-76
17894557-0	2007	20-Hydroxyecdysone regulation of two isoforms of the Ets transcription factor E74 gene in programmed cell death in the silkworm anterior silk gland.	Ecdysterone	0-18	transcription factor E74	Bombyx mori	78-81
17804599-2	2007	npc1a, the Drosophila NPC1 ortholog, regulates sterol homeostasis and is essential for molting hormone (20-hydroxyecdysone; 20E) biosynthesis.	Ecdysterone	104-122	Niemann-Pick type C-1a	Drosophila melanogaster	22-26
17582738-2	2007	20-hydroxyecdysone interacts with juvenile hormone to control insect growth and development and then activates several transcription factors, i.e., Broad, E74, and E75, and, subsequently, the late target genes.	Ecdysterone	0-18	transcription factor E74	Bombyx mori	155-158
17582738-2	2007	20-hydroxyecdysone interacts with juvenile hormone to control insect growth and development and then activates several transcription factors, i.e., Broad, E74, and E75, and, subsequently, the late target genes.	Ecdysterone	0-18	nuclear hormone receptor E75	Bombyx mori	164-167
17679695-4	2007	In Drosophila, the salivary gland is sculpted by caspase-mediated programmed cell death initiated by the steroid hormone 20-hydroxyecdysone (ecdysone).	Ecdysterone	121-139	Death caspase-1	Drosophila melanogaster	49-56
17570489-0	2007	Tissue-specific regulation of juvenile hormone esterase gene expression by 20-hydroxyecdysone and juvenile hormone in Bombyx mori.	Ecdysterone	75-93	juvenile hormone esterase 1	Bombyx mori	30-55
17570489-5	2007	When 20-hydroxyecdysone (20E) was injected into mid-5th instar larvae, JHE mRNA expression was induced in the anterior silk gland but suppressed in the fat body.	Ecdysterone	5-23	juvenile hormone esterase 1	Bombyx mori	71-74
18080490-5	2007	Ecdysterone treatment normalized the levels of stable NO metabolites, ability to generate superoxide, iNOS and nNOS activity, but not bilirubine level, NR and AII activity.	Ecdysterone	0-11	nitric oxide synthase 2	Rattus norvegicus	102-106
17899820-1	2007	The effect of various duration of heat stress (38 degrees C) on the activity of ecdysone 20-monooxygenase converting ecdysone into 20-hydroxyecdysone has been studied in D. virilis of wild type and mutant strain females, which differ by the mode of heat stress response of ecdysone and 20-hydroxyecdysone.	Ecdysterone	131-149	shade	Drosophila melanogaster	80-105
17899820-2	2007	We are the first to show that heat stress induces activity of ecdysone 20-monooxygenase in Drosophila females and enzyme activity correlates with the level of 20-hydroxyecdysone.	Ecdysterone	159-177	shade	Drosophila melanogaster	62-87
18080490-5	2007	Ecdysterone treatment normalized the levels of stable NO metabolites, ability to generate superoxide, iNOS and nNOS activity, but not bilirubine level, NR and AII activity.	Ecdysterone	0-11	nitric oxide synthase 1	Rattus norvegicus	111-115
17015464-3	2006	The betaFtz-F1 orphan nuclear receptor acts as a competence factor for the steroid hormone 20-hydroxyecdysone (20E) in Drosophila melanogaster metamorphosis and mosquito reproduction.	Ecdysterone	91-109	ftz transcription factor 1	Drosophila melanogaster	4-14
16368930-7	2006	Moreover, mmy expression is selectively upregulated in epithelia at the time they actively deposit aECM, and is altered by the moulting hormone 20-Hydroxyecdysone, suggesting that mmy is part of a developmental genetic programme to promote aECM formation.	Ecdysterone	144-162	mummy	Drosophila melanogaster	10-13
16911531-1	2006	The steroid hormone 20-hydroxyecdysone (20E) initiates insect molting and metamorphosis through binding with a heterodimer of two nuclear receptors, the ecdysone receptor (EcR) and ultraspiracle (USP).	Ecdysterone	20-38	ecdysone receptor	Bombyx mori	153-170
16911531-1	2006	The steroid hormone 20-hydroxyecdysone (20E) initiates insect molting and metamorphosis through binding with a heterodimer of two nuclear receptors, the ecdysone receptor (EcR) and ultraspiracle (USP).	Ecdysterone	20-38	ecdysone receptor	Bombyx mori	172-175
16911531-1	2006	The steroid hormone 20-hydroxyecdysone (20E) initiates insect molting and metamorphosis through binding with a heterodimer of two nuclear receptors, the ecdysone receptor (EcR) and ultraspiracle (USP).	Ecdysterone	20-38	protein ultraspiracle homolog	Bombyx mori	196-199
16783823-1	2006	Ecdysone receptor (EcR) and its heterodimer, ultraspiracle protein (USP), are ligand-dependent transcriptional factors that mediate the action of molting hormone 20-hydroxyecdysone.	Ecdysterone	162-180	Ecdysone receptor	Drosophila melanogaster	0-17
16783823-1	2006	Ecdysone receptor (EcR) and its heterodimer, ultraspiracle protein (USP), are ligand-dependent transcriptional factors that mediate the action of molting hormone 20-hydroxyecdysone.	Ecdysterone	162-180	Ecdysone receptor	Drosophila melanogaster	19-22
16783823-1	2006	Ecdysone receptor (EcR) and its heterodimer, ultraspiracle protein (USP), are ligand-dependent transcriptional factors that mediate the action of molting hormone 20-hydroxyecdysone.	Ecdysterone	162-180	ultraspiracle	Drosophila melanogaster	45-66
16783823-1	2006	Ecdysone receptor (EcR) and its heterodimer, ultraspiracle protein (USP), are ligand-dependent transcriptional factors that mediate the action of molting hormone 20-hydroxyecdysone.	Ecdysterone	162-180	ultraspiracle	Drosophila melanogaster	68-71
16427073-2	2006	The more active form of these hormones, 20-hydroxyecdysone (20E), acts upon binding to its heterodimeric receptor, formed by the two nuclear receptors, EcR and RXR/USP.	Ecdysterone	40-58	ultraspiracle	Drosophila melanogaster	164-167
16246375-10	2006	The results indicate that ecdysterone is able to exert the glucose-lowering effect in hepatocytes which is insulin-independent, but has no effect on insulin release.	Ecdysterone	26-37	insulin	Homo sapiens	107-114
16273522-1	2006	Periodic pulses of the insect steroid molting hormone 20-hydroxyecdysone (20E), acting via its nuclear receptor complex (EcR/USP), control gene expression at many stages throughout Drosophila development.	Ecdysterone	54-72	Ecdysone receptor	Drosophila melanogaster	121-124
16273522-1	2006	Periodic pulses of the insect steroid molting hormone 20-hydroxyecdysone (20E), acting via its nuclear receptor complex (EcR/USP), control gene expression at many stages throughout Drosophila development.	Ecdysterone	54-72	ultraspiracle	Drosophila melanogaster	125-128
16368930-7	2006	Moreover, mmy expression is selectively upregulated in epithelia at the time they actively deposit aECM, and is altered by the moulting hormone 20-Hydroxyecdysone, suggesting that mmy is part of a developmental genetic programme to promote aECM formation.	Ecdysterone	144-162	mummy	Drosophila melanogaster	180-183
16230625-1	2005	A number of insect effector genes activated by the steroid hormone 20-hydroxyecdysone (20E) are dually controlled by the ecdysteroid receptor (EcR/USP) and products of ecdysteroid early responsive genes (E74, E75, and Broad).	Ecdysterone	67-85	protein ultraspiracle	Aedes aegypti	147-150
16079224-7	2006	The recessive lethal phenotype of NPC1a mutants can be partially rescued on a diet of high cholesterol or one that includes the insect steroid hormone 20-hydroxyecdysone.	Ecdysterone	151-169	Niemann-Pick type C-1a	Drosophila melanogaster	34-39
16271363-7	2006	Addition of molting hormone, 20-hydroxyecdysone, circumstantially enhanced the hematopoietic activity of bombyxin and insulin.	Ecdysterone	29-47	insulin	Bos taurus	118-125
16325168-1	2005	The steroid hormone 20-hydroxyecdysone (ecdysone) activates a relatively small number of immediate-early genes during Drosophila pupal development, yet is able to orchestrate distinct differentiation events in a wide variety of tissues.	Ecdysterone	20-38	Partner of Bursicon	Drosophila melanogaster	129-134
16230625-1	2005	A number of insect effector genes activated by the steroid hormone 20-hydroxyecdysone (20E) are dually controlled by the ecdysteroid receptor (EcR/USP) and products of ecdysteroid early responsive genes (E74, E75, and Broad).	Ecdysterone	67-85	ecdysone-inducible protein E75	Aedes aegypti	209-212
14693382-5	2004	The holoreceptor of 20-hydroxyecdysone consists of two nuclear receptors (NRs) ecdysone receptor (EcR) and ultraspiracle (USP), USP being the insect orthologue of the vertebrate RXR.	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	98-101
16055147-6	2005	To verify whether the high Hex 70b expression is dependent on high hormone levels, we treated 5th instar larvae with JH or 20-hydroxyecdysone (20E).	Ecdysterone	123-141	hexamerin 70b	Apis mellifera	27-34
15987944-3	2005	Here, we describe the activation of a novel, neuronally expressed Drosophila GPCR by the insect ecdysteroids ecdysone (E) and 20-hydroxyecdysone (20E).	Ecdysterone	126-144	Octopamine receptor in mushroom bodies	Drosophila melanogaster	77-81
15794746-6	2005	Overexpression in Sf9 cells of recombinant Drosophila melanogaster ultraspiracle (dUSP) fostered formation of dUSP oligomer (potentially homodimer), as measured by coimmunoprecipitation assay and electrophoretic mobility assay (EMSA) on a DR1 probe, and also increased the level of transcription in response to JH III, but did not increase the transcriptional response to either 20OHE treatment alone or to the two hormones together.	Ecdysterone	379-384	ultraspiracle	Drosophila melanogaster	82-86
15794746-6	2005	Overexpression in Sf9 cells of recombinant Drosophila melanogaster ultraspiracle (dUSP) fostered formation of dUSP oligomer (potentially homodimer), as measured by coimmunoprecipitation assay and electrophoretic mobility assay (EMSA) on a DR1 probe, and also increased the level of transcription in response to JH III, but did not increase the transcriptional response to either 20OHE treatment alone or to the two hormones together.	Ecdysterone	379-384	ultraspiracle	Drosophila melanogaster	110-114
15794746-7	2005	Inapposite, overexpression of recombinant D. melanogaster ecdysone receptor (dEcR) in the transfected cells generated dUSP/dEcR heterodimer [as measured by EMSA (supershift) on a DR1 probe] and increased the transcriptional response to 20OHE-alone treatment, but did not increase the transcriptional response to the JH III-alone treatment.	Ecdysterone	236-241	Ecdysone receptor	Drosophila melanogaster	77-81
15890182-9	2005	20-hydroxyecdysone induced DHR3 mRNA and suppressed JH III induction of DmJhe mRNA.	Ecdysterone	0-18	Hormone receptor 3	Drosophila melanogaster	27-31
15890182-9	2005	20-hydroxyecdysone induced DHR3 mRNA and suppressed JH III induction of DmJhe mRNA.	Ecdysterone	0-18	Juvenile hormone esterase	Drosophila melanogaster	72-77
16399407-3	2005	Over the past several years, the use of the fly database and the techniques and paradigms of biochemistry, analytical chemistry, and molecular genetics have allowed the cloning and sequencing of four genes in the Halloween gene family of Drosophila melanogaster, all of them encoding cytochrome P450 (CYP) enzymes, each of which mediates one of the four terminal hydroxylation steps in 20E biosynthesis.	Ecdysterone	386-389	disembodied	Drosophila melanogaster	284-299
15342648-6	2004	The level of Croquemort, a candidate phagocytosis receptor of Drosophila hemocytes/macrophages, increased in l(2)mbn cells after treatment with 20-hydroxyecdysone, whereas that of Draper, another candidate phagocytosis receptor, remained unchanged.	Ecdysterone	144-162	croquemort	Drosophila melanogaster	13-23
15303649-8	2004	Ecdysterone was shown to improve the learning and memory of the rats and increase the expression of c-fos.	Ecdysterone	0-11	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	100-105
16061249-0	2005	In vivo role of 20-hydroxyecdysone in the regulation of the vitellogenin mRNA and egg development in the American dog tick, Dermacentor variabilis (Say).	Ecdysterone	16-34	vitellogenin	Oryctolagus cuniculus	60-72
16061249-1	2005	Injection of the hormone 20-hydroxyecdysone (20-E) into partially fed (virgin) female adults of the American dog tick, Dermacentor variabilis, while they are attached and feeding on the rabbit host, initiated the expression of the vitellogenin (Vg) gene, and Vg protein secretion and uptake by the ovary.	Ecdysterone	25-43	vitellogenin	Oryctolagus cuniculus	231-243
16061249-1	2005	Injection of the hormone 20-hydroxyecdysone (20-E) into partially fed (virgin) female adults of the American dog tick, Dermacentor variabilis, while they are attached and feeding on the rabbit host, initiated the expression of the vitellogenin (Vg) gene, and Vg protein secretion and uptake by the ovary.	Ecdysterone	25-43	vitellogenin	Oryctolagus cuniculus	245-247
16061249-1	2005	Injection of the hormone 20-hydroxyecdysone (20-E) into partially fed (virgin) female adults of the American dog tick, Dermacentor variabilis, while they are attached and feeding on the rabbit host, initiated the expression of the vitellogenin (Vg) gene, and Vg protein secretion and uptake by the ovary.	Ecdysterone	25-43	vitellogenin	Oryctolagus cuniculus	259-261
16034983-3	2005	In vivo hormone treatment experiments suggest that the decrease of 20-hydroxyecdysone concentration occurring in previtellogenic phases allows Vg production.	Ecdysterone	67-85	vitellogenin	Apis mellifera	143-145
15110862-8	2004	The negative regulation of AmTRF by ecdysteroids deduced from the developmental expression profile was confirmed by experimental treatment of spinning-stage honey bee larvae with 20-hydroxyecdysone, and of fourth instar-larvae with juvenile hormone.	Ecdysterone	179-197	transferrin 1	Apis mellifera	27-32
15026169-5	2004	A third enzyme, necessary for the critical conversion of ecdysone to 20-hydroxyecdysone, the 20-monooxygenase, is encoded by shade (shd) (CYP314A1).	Ecdysterone	69-87	shade	Drosophila melanogaster	138-146
14693382-5	2004	The holoreceptor of 20-hydroxyecdysone consists of two nuclear receptors (NRs) ecdysone receptor (EcR) and ultraspiracle (USP), USP being the insect orthologue of the vertebrate RXR.	Ecdysterone	20-38	ultraspiracle	Drosophila melanogaster	122-125
14693382-5	2004	The holoreceptor of 20-hydroxyecdysone consists of two nuclear receptors (NRs) ecdysone receptor (EcR) and ultraspiracle (USP), USP being the insect orthologue of the vertebrate RXR.	Ecdysterone	20-38	ultraspiracle	Drosophila melanogaster	128-131
14599496-5	2003	Each of the EcR variants responded to the synthetic ecdysteroid, muristerone A (murA), but a maximal response to 20-hydroxyecdysone (20E) was achieved only for specific EcR combinations with its heterodimeric partner.	Ecdysterone	113-131	Ecdysone receptor	Drosophila melanogaster	12-15
14599496-5	2003	Each of the EcR variants responded to the synthetic ecdysteroid, muristerone A (murA), but a maximal response to 20-hydroxyecdysone (20E) was achieved only for specific EcR combinations with its heterodimeric partner.	Ecdysterone	113-131	Ecdysone receptor	Drosophila melanogaster	169-172
12093364-0	2002	Ance, a Drosophila angiotensin-converting enzyme homologue, is expressed in imaginal cells during metamorphosis and is regulated by the steroid, 20-hydroxyecdysone.	Ecdysterone	145-163	Angiotensin converting enzyme	Drosophila melanogaster	0-4
12674500-1	2003	Two members of the nuclear receptor superfamily, EcR (ecdysteroid receptor protein) and Usp (Ultraspiracle), heterodimerize to form a functional receptor for the steroid hormone 20-hydroxyecdysone and thus enable it to coordinate morphogenetic events during insect metamorphosis.	Ecdysterone	178-196	ultraspiracle	Drosophila melanogaster	88-91
12674500-1	2003	Two members of the nuclear receptor superfamily, EcR (ecdysteroid receptor protein) and Usp (Ultraspiracle), heterodimerize to form a functional receptor for the steroid hormone 20-hydroxyecdysone and thus enable it to coordinate morphogenetic events during insect metamorphosis.	Ecdysterone	178-196	ultraspiracle	Drosophila melanogaster	93-106
12386839-8	2002	These results suggest that 20-hydroxyecdysone, via the ecdysteroid receptor, is responsible for the developmental difference between diapause and non-diapause in B. mori embryos.	Ecdysterone	27-45	ecdysone receptor	Bombyx mori	55-75
12200421-1	2002	The orphan nuclear receptors BmE75 and BmHR3 are induced by 20-hydroxyecdysone in the ovary of the silk moth Bombyx mori at the beginning of pupation and show stage-specific expression in ovarian follicles during pharate adult development.	Ecdysterone	60-78	nuclear hormone receptor E75	Bombyx mori	29-34
12200421-1	2002	The orphan nuclear receptors BmE75 and BmHR3 are induced by 20-hydroxyecdysone in the ovary of the silk moth Bombyx mori at the beginning of pupation and show stage-specific expression in ovarian follicles during pharate adult development.	Ecdysterone	60-78	hormone receptor 3	Bombyx mori	39-44
12093364-9	2002	Physiological levels of 20-hydroxyecdysone induced the synthesis of ACE-like activity and Ance protein by a wing disc cell line (Cl.8+), confirming that Ance is an ecdysteroid-responsive gene.	Ecdysterone	24-42	angiotensin I converting enzyme	Homo sapiens	68-71
12093364-9	2002	Physiological levels of 20-hydroxyecdysone induced the synthesis of ACE-like activity and Ance protein by a wing disc cell line (Cl.8+), confirming that Ance is an ecdysteroid-responsive gene.	Ecdysterone	24-42	Angiotensin converting enzyme	Drosophila melanogaster	90-94
12093364-9	2002	Physiological levels of 20-hydroxyecdysone induced the synthesis of ACE-like activity and Ance protein by a wing disc cell line (Cl.8+), confirming that Ance is an ecdysteroid-responsive gene.	Ecdysterone	24-42	Angiotensin converting enzyme	Drosophila melanogaster	153-157
11755056-5	2002	Injection of 20-hydroxyecdysone (20E) into feeding last instar larvae induced accumulation of BmChiR1 mRNA.	Ecdysterone	13-31	chitinase-related protein 1	Bombyx mori	94-101
12370123-9	2002	Transient transfection assays in Drosophila S2 cells showed that AaSvp was able to repress 20-hydroxyecdysone (20E)-dependent transactivation mediated by the mosquito ecdysteroid receptor complex.	Ecdysterone	91-109	nuclear receptor subfamily 2 group F member 1-B	Aedes aegypti	65-70
12176145-0	2002	Production of the baculovirus-expressed dengue virus glycoprotein NS1 can be improved dramatically with optimised regimes for fed-batch cultures and the addition of the insect moulting hormone, 20-Hydroxyecdysone.	Ecdysterone	194-212	influenza virus NS1A binding protein	Homo sapiens	66-69
11923209-6	2002	In addition, both GAL4-EcR and GAL4-USP are activated in larval organs cultured with 20-hydroxyecdysone (20E), consistent with EcR/USP acting as a 20E receptor.	Ecdysterone	85-103	Ecdysone receptor	Drosophila melanogaster	23-26
11923209-6	2002	In addition, both GAL4-EcR and GAL4-USP are activated in larval organs cultured with 20-hydroxyecdysone (20E), consistent with EcR/USP acting as a 20E receptor.	Ecdysterone	85-103	ultraspiracle	Drosophila melanogaster	36-39
11254363-0	2001	Regulation of transcription factors MHR4 and betaFTZ-F1 by 20-hydroxyecdysone during a larval molt in the tobacco hornworm, Manduca sexta.	Ecdysterone	59-77	ftz transcription factor 1	Drosophila melanogaster	45-55
11564603-2	2001	The action of 20-hydroxyecdysone is mediated by its binding to the ecdysteroid receptor (EcR), which requires a heterodimeric partner, ultraspiracle protein (USP), a homologue of the retinoid X receptor (RXR).	Ecdysterone	14-32	ultraspiracle	Drosophila melanogaster	158-161
11564603-2	2001	The action of 20-hydroxyecdysone is mediated by its binding to the ecdysteroid receptor (EcR), which requires a heterodimeric partner, ultraspiracle protein (USP), a homologue of the retinoid X receptor (RXR).	Ecdysterone	14-32	retinoid X receptor alpha	Homo sapiens	204-207
11432742-1	2001	The steroid hormone, 20-hydroxyecdysone (20E), directs Drosophila metamorphosis via a heterodimeric receptor formed by two members of the nuclear hormone receptors superfamily, the product of the EcR (EcR) and of the ultraspiracle (Usp) genes.	Ecdysterone	21-39	Ecdysone receptor	Drosophila melanogaster	196-199
11432742-1	2001	The steroid hormone, 20-hydroxyecdysone (20E), directs Drosophila metamorphosis via a heterodimeric receptor formed by two members of the nuclear hormone receptors superfamily, the product of the EcR (EcR) and of the ultraspiracle (Usp) genes.	Ecdysterone	21-39	Ecdysone receptor	Drosophila melanogaster	201-204
11432742-1	2001	The steroid hormone, 20-hydroxyecdysone (20E), directs Drosophila metamorphosis via a heterodimeric receptor formed by two members of the nuclear hormone receptors superfamily, the product of the EcR (EcR) and of the ultraspiracle (Usp) genes.	Ecdysterone	21-39	ultraspiracle	Drosophila melanogaster	232-235
11333238-7	2001	Furthermore, our studies predict the existence of feedback inhibition through protein kinase A on the InsP(3) receptor by increased levels of 20-hydroxyecdysone.	Ecdysterone	142-160	Protein kinase, cAMP-dependent, catalytic subunit 1	Drosophila melanogaster	78-94
11333238-7	2001	Furthermore, our studies predict the existence of feedback inhibition through protein kinase A on the InsP(3) receptor by increased levels of 20-hydroxyecdysone.	Ecdysterone	142-160	Inositol 1,4,5,-trisphosphate receptor	Drosophila melanogaster	102-118
11105053-1	2000	The ultraspiracle (usp) gene encodes a nuclear receptor that forms a heterodimer with the ecdysone receptor (EcR) to mediate transcriptional responses to the insect steroid hormone, 20-hydroxyecdysone (20HE).	Ecdysterone	182-200	ultraspiracle	Drosophila melanogaster	19-22
11105053-1	2000	The ultraspiracle (usp) gene encodes a nuclear receptor that forms a heterodimer with the ecdysone receptor (EcR) to mediate transcriptional responses to the insect steroid hormone, 20-hydroxyecdysone (20HE).	Ecdysterone	182-200	Ecdysone receptor	Drosophila melanogaster	90-107
11105053-1	2000	The ultraspiracle (usp) gene encodes a nuclear receptor that forms a heterodimer with the ecdysone receptor (EcR) to mediate transcriptional responses to the insect steroid hormone, 20-hydroxyecdysone (20HE).	Ecdysterone	182-200	Ecdysone receptor	Drosophila melanogaster	109-112
11180842-3	2000	We have previously shown that the timing of expression of the Ecdysone Receptor (EcR) and Ultraspiracle (USP), the two proteins that constitute the functional receptor for the steroid hormone 20-hydroxyecdysone, regulates the timing and progression of ovarian differentiation in Drosophila melanogaster (Diptera: Drosophilidae).	Ecdysterone	192-210	Ecdysone receptor	Drosophila melanogaster	62-79
10989290-2	2000	Discrete modifications to 20-hydroxyecdysone, the apparent natural ligand for the ecdysone receptor (EcR), conferred dramatic changes on the transcriptional activity of this receptor, suggesting that other biologically relevant EcR ligands may exist.	Ecdysterone	26-44	Ecdysone receptor	Drosophila melanogaster	82-99
10989290-2	2000	Discrete modifications to 20-hydroxyecdysone, the apparent natural ligand for the ecdysone receptor (EcR), conferred dramatic changes on the transcriptional activity of this receptor, suggesting that other biologically relevant EcR ligands may exist.	Ecdysterone	26-44	Ecdysone receptor	Drosophila melanogaster	101-104
10989290-2	2000	Discrete modifications to 20-hydroxyecdysone, the apparent natural ligand for the ecdysone receptor (EcR), conferred dramatic changes on the transcriptional activity of this receptor, suggesting that other biologically relevant EcR ligands may exist.	Ecdysterone	26-44	Ecdysone receptor	Drosophila melanogaster	228-231
11093245-4	2000	It was possible to induce catalase expression by administering exogenous 20-hydroxyecdysone (Ec) in culture at certain stages of development (usually at time points corresponding to previously observed hormone and catalase peaks).	Ecdysterone	73-91	Catalase	Drosophila melanogaster	26-34
11093245-4	2000	It was possible to induce catalase expression by administering exogenous 20-hydroxyecdysone (Ec) in culture at certain stages of development (usually at time points corresponding to previously observed hormone and catalase peaks).	Ecdysterone	73-91	Catalase	Drosophila melanogaster	214-222
11180842-3	2000	We have previously shown that the timing of expression of the Ecdysone Receptor (EcR) and Ultraspiracle (USP), the two proteins that constitute the functional receptor for the steroid hormone 20-hydroxyecdysone, regulates the timing and progression of ovarian differentiation in Drosophila melanogaster (Diptera: Drosophilidae).	Ecdysterone	192-210	Ecdysone receptor	Drosophila melanogaster	81-84
11180842-3	2000	We have previously shown that the timing of expression of the Ecdysone Receptor (EcR) and Ultraspiracle (USP), the two proteins that constitute the functional receptor for the steroid hormone 20-hydroxyecdysone, regulates the timing and progression of ovarian differentiation in Drosophila melanogaster (Diptera: Drosophilidae).	Ecdysterone	192-210	ultraspiracle	Drosophila melanogaster	105-108
10683169-1	2000	The steroid hormone 20-hydroxyecdysone (20E) initiates metamorphosis in insects by signaling through the ecdysone receptor complex, a heterodimer of the ecdysone receptor (EcR) and ultraspiracle (USP).	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	105-122
10778857-1	2000	The steroid hormone 20-hydroxyecdysone coordinates the stages of Drosophila development by activating a nuclear receptor heterodimer consisting of the ecdysone receptor, EcR, and the Drosophila RXR receptor, USP.	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	151-168
10778857-1	2000	The steroid hormone 20-hydroxyecdysone coordinates the stages of Drosophila development by activating a nuclear receptor heterodimer consisting of the ecdysone receptor, EcR, and the Drosophila RXR receptor, USP.	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	170-173
10778857-1	2000	The steroid hormone 20-hydroxyecdysone coordinates the stages of Drosophila development by activating a nuclear receptor heterodimer consisting of the ecdysone receptor, EcR, and the Drosophila RXR receptor, USP.	Ecdysterone	20-38	ultraspiracle	Drosophila melanogaster	208-211
10683169-1	2000	The steroid hormone 20-hydroxyecdysone (20E) initiates metamorphosis in insects by signaling through the ecdysone receptor complex, a heterodimer of the ecdysone receptor (EcR) and ultraspiracle (USP).	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	153-170
10683169-1	2000	The steroid hormone 20-hydroxyecdysone (20E) initiates metamorphosis in insects by signaling through the ecdysone receptor complex, a heterodimer of the ecdysone receptor (EcR) and ultraspiracle (USP).	Ecdysterone	20-38	Ecdysone receptor	Drosophila melanogaster	172-175
10683169-1	2000	The steroid hormone 20-hydroxyecdysone (20E) initiates metamorphosis in insects by signaling through the ecdysone receptor complex, a heterodimer of the ecdysone receptor (EcR) and ultraspiracle (USP).	Ecdysterone	20-38	ultraspiracle	Drosophila melanogaster	196-199
10502114-2	1999	In Drosophila melanogaster, the receptor for the insect molting hormone, 20-hydroxyecdysone, is a heterodimer composed of the Ecdysone Receptor and Ultraspiracle (USP) proteins.	Ecdysterone	73-91	ultraspiracle	Drosophila melanogaster	148-161
10231363-4	1999	Expression of Fbp-1 is induced by a low level of 20-hydroxy-ecdysone (>/= 10-7 m).	Ecdysterone	49-68	Fat body protein 1	Drosophila melanogaster	14-19
10231363-7	1999	Therefore, 20-hydroxy-ecdysone regulates Fbp-1 expression and function at two different levels.	Ecdysterone	11-30	Fat body protein 1	Drosophila melanogaster	41-46
10319443-1	1999	Treating Drosophila Kc tissue culture cells with 20-hydroxyecdysone (20E) causes a rapid 10-fold increase in the synthesis of three polypeptides, with molecular weights of 28 kD, 29 kD, and 40 kD (named EIP28, EIP29, and EIP 40, in reference to their molecular weights), as shown by Savakis et al.	Ecdysterone	49-67	Methionine sulfoxide reductase A	Drosophila melanogaster	203-208
10411302-6	1999	Furthermore, in vitro fat body culture experiments demonstrate that AaE75 isoforms are induced by 20-hydroxyecdysone, an active ecdysteroid in the mosquito.	Ecdysterone	98-116	ecdysone-inducible protein E75	Aedes aegypti	68-73
10319443-1	1999	Treating Drosophila Kc tissue culture cells with 20-hydroxyecdysone (20E) causes a rapid 10-fold increase in the synthesis of three polypeptides, with molecular weights of 28 kD, 29 kD, and 40 kD (named EIP28, EIP29, and EIP 40, in reference to their molecular weights), as shown by Savakis et al.	Ecdysterone	49-67	Ecdysone-induced protein 55E	Drosophila melanogaster	221-227
9755479-3	1998	The mRNAs for hormone receptor 3 homologues cloned from Drosophila (DHR3) and Choristoneura (CHR3) are directly induced by 20-hydroxyecdysone (20E) and serve as suitable markers for studying ecdysone action.	Ecdysterone	123-141	Hormone receptor 3	Drosophila melanogaster	14-32
10398339-1	1999	20-hydroxyecdysone (1 microM) was found to activate in vitro T-cell CD2 presentation, which is suppressed both in secondary immunodeficient persons and pharmacologically by increasing intracellular cAMP levels.	Ecdysterone	0-18	CD2 molecule	Homo sapiens	68-71
10398340-1	1999	Acetonides can be formed between vicinal diols in cis position such as positions C-2/C-3 and C-20/C-22 in 20-hydroxyecdysone, for example.	Ecdysterone	107-125	complement C2	Homo sapiens	82-85
10398340-1	1999	Acetonides can be formed between vicinal diols in cis position such as positions C-2/C-3 and C-20/C-22 in 20-hydroxyecdysone, for example.	Ecdysterone	107-125	complement C3	Homo sapiens	86-89
9790883-7	1998	The gel mobility-shift experiments showed that UspDBD exhibited higher affinity than EcRDBD toward a 20-hydroxyecdysone response element from the Drosophila hsp 27 gene (hsp 27pal).	Ecdysterone	101-119	Heat shock protein 27	Drosophila melanogaster	157-163
9790883-7	1998	The gel mobility-shift experiments showed that UspDBD exhibited higher affinity than EcRDBD toward a 20-hydroxyecdysone response element from the Drosophila hsp 27 gene (hsp 27pal).	Ecdysterone	101-119	Heat shock protein 27	Drosophila melanogaster	170-176
10084681-6	1999	We show that the death of these neurons is dependent upon the fall in the titer of the steroid hormone 20-hydroxyecdysone that occurs at the end of metamorphosis, and demonstrate that the accumulation of both reaper and grim transcripts is inhibited by this steroid hormone.	Ecdysterone	103-121	grim	Drosophila melanogaster	220-224
9755479-3	1998	The mRNAs for hormone receptor 3 homologues cloned from Drosophila (DHR3) and Choristoneura (CHR3) are directly induced by 20-hydroxyecdysone (20E) and serve as suitable markers for studying ecdysone action.	Ecdysterone	123-141	Hormone receptor 3	Drosophila melanogaster	68-72
9413997-2	1997	Late FTZ-F1, a member of the nuclear receptor superfamily, is a unique transcription factor which is induced by a pulse exposure of 20-hydroxyecdysone.	Ecdysterone	132-150	ftz transcription factor 1	Drosophila melanogaster	5-11
9342230-8	1997	In the cultured anterior silk glands of day 0 of the fifth instar, transcription of BmEcR-A and BmEcR-B1 was induced dose dependently by more than 5 ng/ml 20-hydroxyecdysone.	Ecdysterone	155-173	ecdysone receptor	Bombyx mori	84-89
9342230-8	1997	In the cultured anterior silk glands of day 0 of the fifth instar, transcription of BmEcR-A and BmEcR-B1 was induced dose dependently by more than 5 ng/ml 20-hydroxyecdysone.	Ecdysterone	155-173	ecdysone receptor	Bombyx mori	96-101
9342230-9	1997	BmEcR-A and BmEcR-B1 mRNAs were induced within 2 h and 1 h, respectively, of the addition of 20-hydroxyecdysone.	Ecdysterone	93-111	ecdysone receptor	Bombyx mori	0-5
9342230-9	1997	BmEcR-A and BmEcR-B1 mRNAs were induced within 2 h and 1 h, respectively, of the addition of 20-hydroxyecdysone.	Ecdysterone	93-111	ecdysone receptor	Bombyx mori	12-17
9131779-1	1997	Choristoneura hormone receptor 3 (CHR3) is a 20E (20-hydroxyecdysone)-induced delayed early gene that is homologous to Manduca hormone receptor 3 (MHR3), Drosophila hormone receptor 3 (DHR3), and Galleria hormone receptor 3 (GHR3).	Ecdysterone	50-68	Hormone receptor 3	Drosophila melanogaster	14-32
9128741-2	1997	Transcription of Lsp-2 is controlled by 20-hydroxyecdysone.	Ecdysterone	40-58	Larval serum protein 2	Drosophila melanogaster	17-22
9256362-8	1997	This pattern of expression is consistent with the known induction of Cyp18 transcription by 20-hydroxyecdysone at the time of pupariation and suggests that ecdysteroids are major regulators of Cyp18 expression throughout postembryonic development.	Ecdysterone	92-110	Cytochrome P450-18a1	Drosophila melanogaster	69-74
9125169-1	1997	The expression and enzymatic activities of insecticide resistance-related cytochrome P450B are increased by the treatment with 20-hydroxyecdysone (20HE) in D. melanogaster Oregon R flies.	Ecdysterone	127-145	Cytochrome P450-6a2	Drosophila melanogaster	85-90
9125169-1	1997	The expression and enzymatic activities of insecticide resistance-related cytochrome P450B are increased by the treatment with 20-hydroxyecdysone (20HE) in D. melanogaster Oregon R flies.	Ecdysterone	147-151	Cytochrome P450-6a2	Drosophila melanogaster	85-90
9131782-6	1997	However, when JH was applied prior to 20-hydroxyecdysone feeding, the activity of MDH was significantly stimulated.	Ecdysterone	38-56	Malate dehydrogenase 1	Drosophila melanogaster	82-85
9131779-1	1997	Choristoneura hormone receptor 3 (CHR3) is a 20E (20-hydroxyecdysone)-induced delayed early gene that is homologous to Manduca hormone receptor 3 (MHR3), Drosophila hormone receptor 3 (DHR3), and Galleria hormone receptor 3 (GHR3).	Ecdysterone	50-68	Hormone receptor 3	Drosophila melanogaster	185-189
28306084-0	1996	Isolation and characterization of Urbain, a 20-hydroxyecdysone-inducible gene expressed during morphogenesis of Bombyx mori wing imaginal discs.	Ecdysterone	44-62	urbain	Bombyx mori	34-40
9094207-0	1997	IMP-L3, A 20-hydroxyecdysone-responsive gene encodes Drosophila lactate dehydrogenase: structural characterization and developmental studies.	Ecdysterone	10-28	Lactate dehydrogenase	Drosophila melanogaster	0-6
9094207-0	1997	IMP-L3, A 20-hydroxyecdysone-responsive gene encodes Drosophila lactate dehydrogenase: structural characterization and developmental studies.	Ecdysterone	10-28	Lactate dehydrogenase	Drosophila melanogaster	64-85
9094207-3	1997	In cultured imaginal discs, IMP-L3 transcript levels and LDH enzyme activity increase in response to the steroid hormone, 20-hydroxyecdysone.	Ecdysterone	122-140	Lactate dehydrogenase	Drosophila melanogaster	28-34
9094207-3	1997	In cultured imaginal discs, IMP-L3 transcript levels and LDH enzyme activity increase in response to the steroid hormone, 20-hydroxyecdysone.	Ecdysterone	122-140	Lactate dehydrogenase	Drosophila melanogaster	57-60
8973337-2	1996	snwA is homologous to a novel human gene SNW1 and to Bx42 from Drosophila melanogaster, a gene coding for a chromatin binding protein responsive to 20-OH-ecdysone.	Ecdysterone	148-162	SNW domain containing 1	Homo sapiens	53-57
8955885-8	1996	Injection of 20-hydroxyecdysone to insects which were thorax-ligated for 24 and 48 h was found to significantly increase the concentration of actin, suggesting that the ecdysteroids mediate the muscle actin synthesis during the larval development of Corcyra.	Ecdysterone	13-31	actin, beta	Gallus gallus	142-147
8955885-8	1996	Injection of 20-hydroxyecdysone to insects which were thorax-ligated for 24 and 48 h was found to significantly increase the concentration of actin, suggesting that the ecdysteroids mediate the muscle actin synthesis during the larval development of Corcyra.	Ecdysterone	13-31	actin, beta	Gallus gallus	201-206
8890156-2	1996	Two of the Fork head/SEBP2 binding sites are located within an ecdysone response unit which controls the tissue- and stage-specific responses of Sgs-4 to the steroid hormone 20-hydroxyecdysone.	Ecdysterone	174-192	fork head	Drosophila melanogaster	11-20
8890156-2	1996	Two of the Fork head/SEBP2 binding sites are located within an ecdysone response unit which controls the tissue- and stage-specific responses of Sgs-4 to the steroid hormone 20-hydroxyecdysone.	Ecdysterone	174-192	fork head	Drosophila melanogaster	21-26
8890156-2	1996	Two of the Fork head/SEBP2 binding sites are located within an ecdysone response unit which controls the tissue- and stage-specific responses of Sgs-4 to the steroid hormone 20-hydroxyecdysone.	Ecdysterone	174-192	Salivary gland secretion 4	Drosophila melanogaster	145-150
8649409-5	1996	In cell transformation assays, direct repeats DR0 to DR5 alone can render the minimum viral tk or Drosophila Fbp1 promoter responsive to 20-hydroxyecdysone, as does the palindromic hsp27 EcRE.	Ecdysterone	137-155	Fat body protein 1	Drosophila melanogaster	109-113
8649409-5	1996	In cell transformation assays, direct repeats DR0 to DR5 alone can render the minimum viral tk or Drosophila Fbp1 promoter responsive to 20-hydroxyecdysone, as does the palindromic hsp27 EcRE.	Ecdysterone	137-155	Heat shock protein 27	Drosophila melanogaster	181-186
9104497-1	1996	Two members of the nuclear receptor superfamily, EcR and Ultraspiracle (Usp) heterodimerize to form a functional receptor for 20-hydroxyecdysone-the key ecdysteroid controlling induction and modulation of morphogenetic events through Drosophila development.	Ecdysterone	126-144	Ecdysone receptor	Drosophila melanogaster	49-52
8900593-5	1996	BmEcR/BmCF1 forms a specific complex with an ecdysone response element (EcRE) derived from the heat shock protein 27 (hsp27) gene promoter of Drosophila; and, as with DmEcR/DmUSP, formation of this complex is stimulated by the presence of 20-hydroxyecdysone.	Ecdysterone	239-257	ecdysone receptor	Bombyx mori	0-5
8900593-5	1996	BmEcR/BmCF1 forms a specific complex with an ecdysone response element (EcRE) derived from the heat shock protein 27 (hsp27) gene promoter of Drosophila; and, as with DmEcR/DmUSP, formation of this complex is stimulated by the presence of 20-hydroxyecdysone.	Ecdysterone	239-257	protein ultraspiracle homolog	Bombyx mori	6-11
8900593-5	1996	BmEcR/BmCF1 forms a specific complex with an ecdysone response element (EcRE) derived from the heat shock protein 27 (hsp27) gene promoter of Drosophila; and, as with DmEcR/DmUSP, formation of this complex is stimulated by the presence of 20-hydroxyecdysone.	Ecdysterone	239-257	ultraspiracle	Drosophila melanogaster	173-178
8606006-0	1996	20-Hydroxyecdysone, but not juvenile hormone, regulation of yolk protein gene expression can be mapped to cis-acting DNA sequences.	Ecdysterone	0-18	Yolk protein 1	Drosophila melanogaster	60-72
9104497-1	1996	Two members of the nuclear receptor superfamily, EcR and Ultraspiracle (Usp) heterodimerize to form a functional receptor for 20-hydroxyecdysone-the key ecdysteroid controlling induction and modulation of morphogenetic events through Drosophila development.	Ecdysterone	126-144	ultraspiracle	Drosophila melanogaster	57-70
9104497-1	1996	Two members of the nuclear receptor superfamily, EcR and Ultraspiracle (Usp) heterodimerize to form a functional receptor for 20-hydroxyecdysone-the key ecdysteroid controlling induction and modulation of morphogenetic events through Drosophila development.	Ecdysterone	126-144	ultraspiracle	Drosophila melanogaster	72-75
8544820-2	1995	Accumulation of the larval Lsp-2 transcript is enhanced by 20-hydroxyecdysone.	Ecdysterone	59-77	Larval serum protein 2	Drosophila melanogaster	27-32
7479849-6	1995	DHR78 is induced by 20-hydroxyecdysone (20E) in cultured larval organs, and its encoded protein binds to two AGGTCA half-sites arranged as either direct or palindromic repeats.	Ecdysterone	20-38	Hormone-receptor-like in 78	Drosophila melanogaster	0-5
7633470-1	1995	To understand the role that 20-hydroxy-ecdysone (20E) plays during ovarian development in Bombyx mori, we have undertaken the cloning of the silkworm ecdysone receptor (EcR) and a study of its expression during follicular cell differentiation.	Ecdysterone	28-47	ecdysone receptor	Bombyx mori	150-167
7556910-0	1995	The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by 20-hydroxyecdysone.	Ecdysterone	98-116	Ecdysone-induced protein 93F	Drosophila melanogaster	15-18
7633470-1	1995	To understand the role that 20-hydroxy-ecdysone (20E) plays during ovarian development in Bombyx mori, we have undertaken the cloning of the silkworm ecdysone receptor (EcR) and a study of its expression during follicular cell differentiation.	Ecdysterone	28-47	ecdysone receptor	Bombyx mori	169-172
8007953-1	1994	The transcription of the Drosophila melanogaster Fbp1 gene is induced by the steroid hormone 20-hydroxyecdysone and restricted to the late-third-instar fat body tissue.	Ecdysterone	93-111	Fat body protein 1	Drosophila melanogaster	49-53
7750638-0	1995	Characterization of the dopa decarboxylase gene of Manduca sexta and its suppression by 20-hydroxyecdysone.	Ecdysterone	88-106	Dopa decarboxylase	Drosophila melanogaster	24-42
7721865-6	1995	Both accumulation of ubiquitin polypeptide and the enzymes of the conjugation pathway are subject to regulation by declining titers of the insect molting hormone 20-hydroxyecdysone, which signals onset of programmed cell death in the intersegmental muscles.	Ecdysterone	162-180	ubiquitin	Nicotiana tabacum	21-30
7882975-1	1995	The steroid hormone 20-hydroxyecdysone controls both induction and repression of the Drosophila "intermolt gene" Sgs-4.	Ecdysterone	20-38	Salivary gland secretion 4	Drosophila melanogaster	113-118
8150206-6	1994	Injection of 20-hydroxyecdysone at the third day of the 5th instar larvae induced BmFTZ-F1 mRNA in the posterior silk gland after 24 hr.	Ecdysterone	13-31	nuclear hormone receptor FTZ-F1	Bombyx mori	82-90
8150206-7	1994	When 5th instar silk glands were cultured in vitro, BmFTZ-F1 mRNA was induced by a 6-hr exposure to 20-hydroxyecdysone followed by 6 hr in hormone-free medium.	Ecdysterone	100-118	nuclear hormone receptor FTZ-F1	Bombyx mori	52-60
8155577-1	1993	Transcription of the D. melanogaster Fat-body-protein-1 (Fbp1) gene is induced by the steroid hormone 20-hydroxyecdysone and is restricted to the fat body tissue at the end of the third larval instar.	Ecdysterone	102-120	Fat body protein 1	Drosophila melanogaster	37-55
8155577-1	1993	Transcription of the D. melanogaster Fat-body-protein-1 (Fbp1) gene is induced by the steroid hormone 20-hydroxyecdysone and is restricted to the fat body tissue at the end of the third larval instar.	Ecdysterone	102-120	Fat body protein 1	Drosophila melanogaster	57-61
8355263-4	1993	The toxicity of phenobarbital was shown to be decreased by the cytochrome P-450 inhibitor piperonyl butoxide by adding 20-hydroxyecdysone or by treatment with aminophylline--the indirect enhancer of ecdysone production in the larval prothoracic gland.	Ecdysterone	119-137	Cytochrome P450-9b2	Drosophila melanogaster	63-79
8432403-4	1993	Analysis of expression characteristics in imaginal discs cultured in vitro reveals that the IMP-E1 gene is expressed within 15-30 min after exposure to 20-hydroxyecdysone while the expression of the IMP-L1 gene is delayed 6-8 hr.	Ecdysterone	152-170	Ecdysone-inducible gene E1	Drosophila melanogaster	92-98
8325235-3	1993	The other laboratory previously reported that during 20-hydroxyecdysone-induced eversion of Drosophila imaginal discs a glycoprotein named gp125 arises (Birr et al., 1990).	Ecdysterone	53-71	Collagen type IV alpha 1	Drosophila melanogaster	139-144
8432403-7	1993	Differences between the induction characteristics of IMP-E1 and the early 20-hydroxyecdysone-responsive gene E74 lead us to propose an addition to the Ashburner model for the 20-hydroxyecdysone regulatory hierarchy.	Ecdysterone	175-193	Ecdysone-inducible gene E1	Drosophila melanogaster	53-59
9087542-1	1993	In Drosophila Kc cells, the 60C beta3 tubulin transcription unit, whose expression is induced by 20-hydroxyecdysone (20-OHE), has the same structure as in Drosophila.	Ecdysterone	97-115	beta-Tubulin at 60D	Drosophila melanogaster	32-37
1926586-0	1991	[Ecdysterone induces the activity of multiple forms of acid phosphatase and malate dehydrogenase in fat bodies of Anterahea pernyi pupae].	Ecdysterone	1-12	malic enzyme 1	Homo sapiens	76-96
1944271-6	1991	In contrast, high-level expression of the hsp23 gene begins only after a lag of about 6 h, is dependent on the continuous presence of ecdysterone, and is sensitive to low concentrations of protein synthesis inhibitors.	Ecdysterone	134-145	Heat shock protein 23	Drosophila melanogaster	42-47
1653701-1	1991	A gel-filtration assay has been developed with which the specific interaction between Drosophila melanogaster ecdysteroid receptor and the 20-hydroxy-ecdysone responsive element of the hsp27 gene promoter region was characterized in terms of complex formation, saturation of DNA binding and the apparent molecular mass of the complex.	Ecdysterone	139-158	Ecdysone receptor	Drosophila melanogaster	110-130
1653701-1	1991	A gel-filtration assay has been developed with which the specific interaction between Drosophila melanogaster ecdysteroid receptor and the 20-hydroxy-ecdysone responsive element of the hsp27 gene promoter region was characterized in terms of complex formation, saturation of DNA binding and the apparent molecular mass of the complex.	Ecdysterone	139-158	Heat shock protein 27	Drosophila melanogaster	185-190
8394607-8	1993	Simultaneous influence of ecdysterone and vitamin D3 leads to the partial normalization of the biochemical indices studied (except for those which characterize LPO reactions) mainly in the active chromatin fraction.	Ecdysterone	26-37	lactoperoxidase	Rattus norvegicus	160-163
1926586-1	1991	The method of electrophoresis in PAAG has been used to study activity of multiple forms of acid phosphatase and malate dehydrogenase of the fat body of Anterahea pernyi pupae in norm and affected by ecdysterone.	Ecdysterone	199-210	malic enzyme 1	Homo sapiens	112-132
1926586-3	1991	Ecdysterone injection considerably elevates activity of the most electrophoretically mobile form of acid phosphatase and provokes new formation of malate dehydrogenase form.	Ecdysterone	0-11	malic enzyme 1	Homo sapiens	147-167
2118989-3	1990	A direct repeat, 5"-AAGTGAGAGTGAT-3", is the proposed cis-regulatory element involved in 20-hydroxyecdysone repression of the UO gene.	Ecdysterone	89-107	Urate oxidase	Drosophila melanogaster	126-128
1868625-1	1991	A transient expression assay was used to localize cis-acting DNA regulatory elements near the Drosophila heat shock protein (hsp) 22 gene, that are involved in heat shock expression and in ecdysterone-induced expression.	Ecdysterone	189-200	Heat shock protein 22	Drosophila melanogaster	105-132
2081462-1	1990	An apical surface glycoprotein, designated gp125 for its apparent molecular weight of 125,000, appears in Ca2(+)-free, ionic detergent extracts of imaginal discs of Drosophila melanogaster in response to the steroid hormone, 20-hydroxyecdysone (20-HE).	Ecdysterone	225-243	Collagen type IV alpha 1	Drosophila melanogaster	43-48
2081462-1	1990	An apical surface glycoprotein, designated gp125 for its apparent molecular weight of 125,000, appears in Ca2(+)-free, ionic detergent extracts of imaginal discs of Drosophila melanogaster in response to the steroid hormone, 20-hydroxyecdysone (20-HE).	Ecdysterone	245-250	Collagen type IV alpha 1	Drosophila melanogaster	43-48
2081462-2	1990	Gp125 is not synthesized in response to 20-HE, but results from modification of an existing macromolecule.	Ecdysterone	40-45	Collagen type IV alpha 1	Drosophila melanogaster	0-5
28305675-4	1990	The peak in activity reappears when ecd-1 is either shifted back to 20  C after 60 h at 29  C or is fed 20-hydroxyecdysone.	Ecdysterone	104-122	ecdysoneless	Drosophila melanogaster	36-41
28305675-5	1990	At the restrictive temperature, imaginal discs from ecd-1 larvae progressively lose AK activity, whereas discs from 20-hydroxyecdysone-fed larvae have a marked increase in AK activity at stage P3 of the prepupal period.	Ecdysterone	116-134	Arginine kinase	Drosophila melanogaster	172-174
12106278-9	1990	When insulin was added in combination with 20-hydroxyecdysone the stimulation of neurite outgrowth exceeded that seen when insulin was added alone.	Ecdysterone	43-61	insulin	Homo sapiens	123-130
2110062-0	1990	Affinity labelling of a partially purified ecdysteroid receptor with a bromoacetylated 20-OH-ecdysone derivative.	Ecdysterone	87-101	Ecdysone receptor	Drosophila melanogaster	43-63
2110062-6	1990	The value of the apparent reaction rate constant is very similar to that of the association rate constant for the binding of 20-OH-ecdysone to the ecdysteroid receptor.	Ecdysterone	125-139	Ecdysone receptor	Drosophila melanogaster	147-167
2108903-3	1990	Exogeneous treatment of third instar larvae with 20-hydroxyecdysone induces the accumulation of Gld mRNA in the hypoderm and anterior spiracular gland cells.	Ecdysterone	49-67	Glucose dehydrogenase	Drosophila melanogaster	96-99
2306250-2	1990	Forms 1, 2, 3, 5, and 6 catalyzed the formation of 20-hydroxy-ecdysone from ecdysone in the presence of NADPH and pig adrenal adrenodoxin and adrenodoxin reductase at rates not much different that observed in mitochondria; whereas, fraction 4 showed an activity which was about 10-fold higher than mitochondria.	Ecdysterone	51-70	ferredoxin reductase	Sus scrofa	142-163
1976473-16	1990	The role of 20-OH ecdysone in the induction of vitellogenin synthesis in the fat body, as well as the presence of met-enkephalin like immunoreactivity in the gonads is well established in both species.	Ecdysterone	12-26	Yolk protein 1	Drosophila melanogaster	47-59
2349088-0	1990	Regulatory elements in the first intron contribute to transcriptional regulation of the beta 3 tubulin gene by 20-hydroxyecdysone in Drosophila Kc cells.	Ecdysterone	111-129	beta-Tubulin at 60D	Drosophila melanogaster	95-102
2349088-1	1990	We have studied the transcriptional regulation of the beta 3 tubulin gene by the steroid hormone 20-hydroxyecdysone (20-OH-E) in Drosophila Kc cells.	Ecdysterone	97-115	beta-Tubulin at 60D	Drosophila melanogaster	61-68
2407577-0	1990	Regulation of dopa decarboxylase gene expression in the larval epidermis of the tobacco hornworm by 20-hydroxyecdysone and juvenile hormone.	Ecdysterone	100-118	Dopa decarboxylase	Drosophila melanogaster	14-32
2407577-6	1990	Infusion of 1 microgram/hr 20-hydroxyecdysone (20-HE) for 18 hr beginning 2 hr after HCS or addition of 1 microgram/ml 20-HE to the culture medium for 24 hr prevented the normal increase in DDC mRNA.	Ecdysterone	27-45	Dopa decarboxylase	Drosophila melanogaster	190-193
2407577-6	1990	Infusion of 1 microgram/hr 20-hydroxyecdysone (20-HE) for 18 hr beginning 2 hr after HCS or addition of 1 microgram/ml 20-HE to the culture medium for 24 hr prevented the normal increase in DDC mRNA.	Ecdysterone	47-52	Dopa decarboxylase	Drosophila melanogaster	190-193
2407577-6	1990	Infusion of 1 microgram/hr 20-hydroxyecdysone (20-HE) for 18 hr beginning 2 hr after HCS or addition of 1 microgram/ml 20-HE to the culture medium for 24 hr prevented the normal increase in DDC mRNA.	Ecdysterone	119-124	Dopa decarboxylase	Drosophila melanogaster	190-193
2407577-8	1990	Twelve or more hours of incubation with 20-HE was required for an increase in DDC mRNA, but continuous exposure to 20-HE prevented the increase.	Ecdysterone	40-45	Dopa decarboxylase	Drosophila melanogaster	78-81
30270498-2	2019	A 20-hydroxyecdysone pulse allows ftz-f1 gene expression, which then regulates the activity of downstream genes involved in major developmental progression events.	Ecdysterone	2-20	nuclear hormone receptor FTZ-F1	Apis mellifera	34-40
34173258-11	2021	After the 20-hydroxyecdysone (20E) treatment, the expression characteristics of these four genes (BmAtg7, BmAtg8, BmEcr and BmJHBP2) were contrary to the results after depletion of BmAtg7.	Ecdysterone	10-28	autophagy related protein Atg8	Bombyx mori	106-112
34296248-0	2021	20-hydroxyecdysone (20E) signaling regulates amnioserosa morphogenesis during Drosophila dorsal closure: EcR modulates gene expression in a complex with the AP-1 subunit, Jun.	Ecdysterone	0-18	Ecdysone receptor	Drosophila melanogaster	105-108
34296248-0	2021	20-hydroxyecdysone (20E) signaling regulates amnioserosa morphogenesis during Drosophila dorsal closure: EcR modulates gene expression in a complex with the AP-1 subunit, Jun.	Ecdysterone	0-18	Jun-related antigen	Drosophila melanogaster	157-161
34296248-0	2021	20-hydroxyecdysone (20E) signaling regulates amnioserosa morphogenesis during Drosophila dorsal closure: EcR modulates gene expression in a complex with the AP-1 subunit, Jun.	Ecdysterone	20-23	Jun-related antigen	Drosophila melanogaster	157-161
34870111-4	2021	In this regard, the steroid hormone 20-hydroxyecdysone (20E) represents an intriguing candidate for regulating glycolytic gene expression in embryos - not only does the embryonic 20E pulse immediately precede transcriptional up-regulation of glycolytic metabolism, but 20E is also known to promote Lactate dehydrogenase gene expression.	Ecdysterone	36-54	Lactate dehydrogenase	Drosophila melanogaster	298-319
34237140-11	2021	Ecdysterone was also linked to up-regulation of anti-apoptotic protein Bcl-2 and down-regulation of pro-apoptotic proteins Bax and cleaved caspase-3.	Ecdysterone	0-11	BCL2, apoptosis regulator	Rattus norvegicus	71-76
34237140-11	2021	Ecdysterone was also linked to up-regulation of anti-apoptotic protein Bcl-2 and down-regulation of pro-apoptotic proteins Bax and cleaved caspase-3.	Ecdysterone	0-11	BCL2 associated X, apoptosis regulator	Rattus norvegicus	123-126
34237140-11	2021	Ecdysterone was also linked to up-regulation of anti-apoptotic protein Bcl-2 and down-regulation of pro-apoptotic proteins Bax and cleaved caspase-3.	Ecdysterone	0-11	caspase 3	Rattus norvegicus	139-148
34173258-11	2021	After the 20-hydroxyecdysone (20E) treatment, the expression characteristics of these four genes (BmAtg7, BmAtg8, BmEcr and BmJHBP2) were contrary to the results after depletion of BmAtg7.	Ecdysterone	30-33	autophagy related protein Atg8	Bombyx mori	106-112
35514223-0	2022	CYP314A1-dependent 20-hydroxyecdysone biosynthesis is involved in regulating the development of pupal diapause and energy metabolism in the Chinese citrus fruit fly, Bactrocera minax.	Ecdysterone	19-37	shade	Drosophila melanogaster	0-8
34237197-4	2022	Among these genes, dy knockdown increased CYP18A1 expression to elevate the 26-hydroxylation of 20-hydroxyecdysone, which ultimately led to growth defects in wing cells.	Ecdysterone	96-114	cytochrome P450 CYP18A1	Tribolium castaneum	42-49
34207569-1	2021	Ecdysterone is a phytosteroid widely discussed for its various pharmacological, growth-promoting, and anabolic effects, mediated by the activation of estrogen receptor beta (ERbeta).	Ecdysterone	0-11	estrogen receptor 1	Homo sapiens	150-172
34207569-1	2021	Ecdysterone is a phytosteroid widely discussed for its various pharmacological, growth-promoting, and anabolic effects, mediated by the activation of estrogen receptor beta (ERbeta).	Ecdysterone	0-11	estrogen receptor 1	Homo sapiens	174-180
35514223-2	2022	The insect steroid hormone 20-hydroxyecdysone (20E), is converted from ecdysone by the cytochrome P450 enzyme shade (CYP314A1), and it exerts potent effect on the induction and maintenance of diapause in obligatory diapause insects.	Ecdysterone	27-45	shade	Drosophila melanogaster	117-125
35514223-2	2022	The insect steroid hormone 20-hydroxyecdysone (20E), is converted from ecdysone by the cytochrome P450 enzyme shade (CYP314A1), and it exerts potent effect on the induction and maintenance of diapause in obligatory diapause insects.	Ecdysterone	47-50	shade	Drosophila melanogaster	117-125
35523813-3	2022	This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels.	Ecdysterone	188-206	Insulin-like receptor	Drosophila melanogaster	40-47
35514223-11	2022	CONCLUSION: The 20E biosynthesis was regulated by the expression of CYP314A1, and was involved in the induction and termination phase of obligate diapause by regulating energy metabolism in B. minax.	Ecdysterone	16-19	shade	Drosophila melanogaster	68-76
35088829-5	2022	Antp mediates wing growth in Bombyx by directly regulating the ecdysteriod biosynthesis enzyme gene (shade) in the wing tissue, which leads to local production of the growth hormone 20-hydroxyecdysone.	Ecdysterone	182-200	Antennapedia	Drosophila melanogaster	0-4
35323526-1	2022	Fushi Tarazu Factor 1 (FTZ-F1), a member of the nuclear receptor superfamily, is the downstream factor of 20-hydroxyecdysone signaling.	Ecdysterone	106-124	ftz transcription factor 1	Drosophila melanogaster	23-29
35311602-1	2022	AIM: To prepare ecdysterone(ES)/hydroxypropyl-beta-cyclodextrin(HP-beta-CD) inclusion complex, thus improving the water solubility and bioavailability of ES.	Ecdysterone	16-27	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	67-74
2508058-0	1989	A member of the steroid hormone receptor gene family is expressed in the 20-OH-ecdysone inducible puff 75B in Drosophila melanogaster.	Ecdysterone	73-87	Ecdysone-induced protein 75B	Drosophila melanogaster	103-106
2508058-1	1989	Drosophila melanogaster DNA has been cloned which encompasses a major part of the 20-OH-ecdysone inducible puff 75B.	Ecdysterone	82-96	Ecdysone-induced protein 75B	Drosophila melanogaster	112-115
2508058-3	1989	This accumulation is correlated with the 20-OH-ecdysone induced activity of puff 75B.	Ecdysterone	41-55	Ecdysone-induced protein 75B	Drosophila melanogaster	81-84
2508058-6	1989	A study of the tissue distribution in larvae revealed that 75B mRNA is present in most, if not all 20-OH-ecdysone target tissues.	Ecdysterone	99-113	Ecdysone-induced protein 75B	Drosophila melanogaster	59-62
2508058-7	1989	It is proposed that 75B protein is a DNA-binding protein playing a key role in mediating the regulation of the larval molt by 20-OH-ecdysone.	Ecdysterone	126-140	Ecdysone-induced protein 75B	Drosophila melanogaster	20-23
3393913-2	1988	In ecdysone-sensitive Drosophila Kc cells, the insecticide RH 5849 (1,2-dibenzoyl-1-tert-butylhydrazine) mimics the action of 20-hydroxyecdysone by causing the formation of processes, an inhibition of cell proliferation, and induction of acetylcholinesterase.	Ecdysterone	126-144	Acetylcholine esterase	Drosophila melanogaster	238-258
2504635-1	1989	The temporal patterns of glucose dehydrogenase (Gld) and alcohol dehydrogenase (Adh) expression in Drosophila are correlated positively and negatively, respectively, with ecdysterone titers during the late third instar.	Ecdysterone	171-182	Glucose dehydrogenase	Drosophila melanogaster	25-46
2504635-1	1989	The temporal patterns of glucose dehydrogenase (Gld) and alcohol dehydrogenase (Adh) expression in Drosophila are correlated positively and negatively, respectively, with ecdysterone titers during the late third instar.	Ecdysterone	171-182	Glucose dehydrogenase	Drosophila melanogaster	48-51
2504635-1	1989	The temporal patterns of glucose dehydrogenase (Gld) and alcohol dehydrogenase (Adh) expression in Drosophila are correlated positively and negatively, respectively, with ecdysterone titers during the late third instar.	Ecdysterone	171-182	Alcohol dehydrogenase	Drosophila melanogaster	57-78
2504635-1	1989	The temporal patterns of glucose dehydrogenase (Gld) and alcohol dehydrogenase (Adh) expression in Drosophila are correlated positively and negatively, respectively, with ecdysterone titers during the late third instar.	Ecdysterone	171-182	Alcohol dehydrogenase	Drosophila melanogaster	80-83
2506151-1	1989	Transcript accumulation of the 3C glue protein gene Sgs-4 was induced in cultured salivary glands of Drosophila third instar larvae by supplementing the culture medium with 20-OH-ecdysone.	Ecdysterone	173-187	Salivary gland secretion 4	Drosophila melanogaster	52-57
2461886-6	1988	Transcripts corresponding to EDG-64CD exhibit delayed accumulation in the continuous presence of 20-HE.	Ecdysterone	97-102	Edg64CD	Drosophila melanogaster	29-37
2507336-0	1989	20-OH-ecdysone regulates 60 C beta tubulin gene expression in Kc cells and during Drosophila development.	Ecdysterone	0-14	beta-Tubulin at 60D	Drosophila melanogaster	25-42
3556581-0	1987	Counteraction by 20-hydroxyecdysone of the effect of juvenile hormone on phosphorylation of ribosomal protein S6.	Ecdysterone	17-35	Ribosomal protein S6	Drosophila melanogaster	92-112
2461849-2	1988	Transcription of the genes is regulated by the genes tra, tra-2 and dsx and also by the insect hormones, juvenile hormone and 20-hydroxyecdysone.	Ecdysterone	126-144	transformer	Drosophila melanogaster	53-56
2461849-2	1988	Transcription of the genes is regulated by the genes tra, tra-2 and dsx and also by the insect hormones, juvenile hormone and 20-hydroxyecdysone.	Ecdysterone	126-144	transformer 2	Drosophila melanogaster	58-63
2461849-2	1988	Transcription of the genes is regulated by the genes tra, tra-2 and dsx and also by the insect hormones, juvenile hormone and 20-hydroxyecdysone.	Ecdysterone	126-144	doublesex	Drosophila melanogaster	68-71
3503705-2	1987	20-hydroxyecdysone can affect the transcription of these genes in males and females, as can mutations in the sex-determining genes tra, tra-2, ix and dsx.	Ecdysterone	0-18	transformer	Drosophila melanogaster	34-37
3503705-2	1987	20-hydroxyecdysone can affect the transcription of these genes in males and females, as can mutations in the sex-determining genes tra, tra-2, ix and dsx.	Ecdysterone	0-18	transformer 2	Drosophila melanogaster	136-141
3503705-2	1987	20-hydroxyecdysone can affect the transcription of these genes in males and females, as can mutations in the sex-determining genes tra, tra-2, ix and dsx.	Ecdysterone	0-18	doublesex	Drosophila melanogaster	150-153
3503705-7	1987	20-hydroxyecdysone can override the sex-determination system and induce yolk protein synthesis in normal males and tra-2ts reared and maintained at the restrictive temperature.	Ecdysterone	0-18	transformer 2	Drosophila melanogaster	115-120
2825814-1	1988	The expression of 56D and 60C beta-tubulin genes has been examined in Drosophila melanogaster Kc cells in response to the insect moulting hormone, 20-hydroxyecdysone (20-OH-E).	Ecdysterone	147-165	Odorant-binding protein 56d	Drosophila melanogaster	18-21
3926562-0	1985	Ecdysterone selectively stimulates the expression of a 23000-Da heat-shock protein-beta-galactosidase hybrid gene in cultured Drosophila cells.	Ecdysterone	0-11	beta galactosidase	Drosophila melanogaster	83-101
3025658-0	1986	Modulation of novel-length DOPA decarboxylase transcripts by 20-OH-ecdysone in a Drosophila melanogaster Kc cell subline.	Ecdysterone	61-75	Dopa decarboxylase	Drosophila melanogaster	27-45
3025658-1	1986	The induction of DOPA decarboxylase (DDC) activity by 20-OH-ecdysone (20-OHE) in a subline of Drosophila melanogaster Kc cells was investigated.	Ecdysterone	54-68	Dopa decarboxylase	Drosophila melanogaster	17-35
3025658-1	1986	The induction of DOPA decarboxylase (DDC) activity by 20-OH-ecdysone (20-OHE) in a subline of Drosophila melanogaster Kc cells was investigated.	Ecdysterone	54-68	Dopa decarboxylase	Drosophila melanogaster	37-40
3025658-1	1986	The induction of DOPA decarboxylase (DDC) activity by 20-OH-ecdysone (20-OHE) in a subline of Drosophila melanogaster Kc cells was investigated.	Ecdysterone	70-76	Dopa decarboxylase	Drosophila melanogaster	17-35
3025658-1	1986	The induction of DOPA decarboxylase (DDC) activity by 20-OH-ecdysone (20-OHE) in a subline of Drosophila melanogaster Kc cells was investigated.	Ecdysterone	70-76	Dopa decarboxylase	Drosophila melanogaster	37-40
24305901-8	1986	In addition, we have demonstrated that the enzymes Superoxide dismutase (SOD, EC 1.15.1.1) were present in schistosomes and that the total Superoxide dismutase activities in both males and females could be correlated with the 20-hydroxyecdysone within parasites.	Ecdysterone	226-244	superoxide dismutase 1	Homo sapiens	51-71
24305901-8	1986	In addition, we have demonstrated that the enzymes Superoxide dismutase (SOD, EC 1.15.1.1) were present in schistosomes and that the total Superoxide dismutase activities in both males and females could be correlated with the 20-hydroxyecdysone within parasites.	Ecdysterone	226-244	superoxide dismutase 1	Homo sapiens	73-76
24305901-8	1986	In addition, we have demonstrated that the enzymes Superoxide dismutase (SOD, EC 1.15.1.1) were present in schistosomes and that the total Superoxide dismutase activities in both males and females could be correlated with the 20-hydroxyecdysone within parasites.	Ecdysterone	226-244	superoxide dismutase 1	Homo sapiens	139-159
3007239-0	1986	Differential responses of the dopa decarboxylase gene to 20-OH-ecdysone in Drosophila melanogaster.	Ecdysterone	57-71	Dopa decarboxylase	Drosophila melanogaster	30-48
3007239-1	1986	The dopa decarboxylase gene (Ddc) of Drosophila melanogaster responds to 20-OH-ecdysone in the mature larval epidermis and in imaginal discs (presumptive adult epidermis) in a tissue-specific manner.	Ecdysterone	73-87	Dopa decarboxylase	Drosophila melanogaster	4-22
3007239-1	1986	The dopa decarboxylase gene (Ddc) of Drosophila melanogaster responds to 20-OH-ecdysone in the mature larval epidermis and in imaginal discs (presumptive adult epidermis) in a tissue-specific manner.	Ecdysterone	73-87	Dopa decarboxylase	Drosophila melanogaster	29-32
3007239-2	1986	Exposure of the mature larval epidermis to 20-OH-ecdysone caused a rapid accumulation of DDC transcripts.	Ecdysterone	43-57	Dopa decarboxylase	Drosophila melanogaster	89-92
3007239-5	1986	However, when discs were exposed to 20-OH-ecdysone and then cultured in its absence, DDC activity and DDC transcript levels started to increase 6 hr after hormone withdrawal.	Ecdysterone	36-50	Dopa decarboxylase	Drosophila melanogaster	85-88
3007239-5	1986	However, when discs were exposed to 20-OH-ecdysone and then cultured in its absence, DDC activity and DDC transcript levels started to increase 6 hr after hormone withdrawal.	Ecdysterone	36-50	Dopa decarboxylase	Drosophila melanogaster	102-105
3749134-0	1986	Differential induction of dopa decarboxylase activity by 20-OH ecdysone in sublines of the Drosophila Kc cell line.	Ecdysterone	57-71	Dopa decarboxylase	Drosophila melanogaster	26-44
6146468-0	1984	Ecdysterone induces acetylcholinesterase in mammalian brain.	Ecdysterone	0-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-40
3917412-10	1985	This rules out the existence of a distinct embryonic DDC gene unresponsive to 20-OH-ecdysone.	Ecdysterone	78-92	Dopa decarboxylase	Drosophila melanogaster	53-56
3917412-11	1985	Second, no evidence was found to support the hypothesis that a delay in the translation of DDC transcripts, produced in response to the elevated titer of 20-OH-ecdysone at midembryogenesis, caused the lag.	Ecdysterone	154-168	Dopa decarboxylase	Drosophila melanogaster	91-94
6588379-8	1984	beta-Ecdysterone, the Drosophila molting hormone, also inhibits embryonic differentiation and induces hsp 23, 22a, and 22b, a partial subset of the heat shock proteins (hsp 22, 23, 26, and 27) induced by the hormone in imaginal discs and some Drosophila continuous cell lines.	Ecdysterone	0-16	Heat shock protein 23	Drosophila melanogaster	102-108
6588379-8	1984	beta-Ecdysterone, the Drosophila molting hormone, also inhibits embryonic differentiation and induces hsp 23, 22a, and 22b, a partial subset of the heat shock proteins (hsp 22, 23, 26, and 27) induced by the hormone in imaginal discs and some Drosophila continuous cell lines.	Ecdysterone	0-16	Heat shock protein 22	Drosophila melanogaster	169-175
3891759-0	1985	The pupal cuticle of Drosophila: biphasic synthesis of pupal cuticle proteins in vivo and in vitro in response to 20-hydroxyecdysone.	Ecdysterone	114-132	Partner of Bursicon	Drosophila melanogaster	4-9
3891759-0	1985	The pupal cuticle of Drosophila: biphasic synthesis of pupal cuticle proteins in vivo and in vitro in response to 20-hydroxyecdysone.	Ecdysterone	114-132	Partner of Bursicon	Drosophila melanogaster	55-60
3891759-6	1985	The low molecular weight pupal cuticle proteins accumulate in response to a pulse of the insect steroid hormone 20-hydroxyecdysone and begin to appear 6 h after the withdrawal of the hormone from the culture medium.	Ecdysterone	112-130	Partner of Bursicon	Drosophila melanogaster	25-30
6436495-3	1984	The results indicate that relative to hsp22, the rate of hsp23 synthesis is significantly greater during recovery from heat shock and during ecdysterone induction.	Ecdysterone	141-152	Heat shock protein 23	Drosophila melanogaster	57-62
6427061-15	1984	Nearly normal levels of ecdysteroids appeared at 27.5 degrees C. Feeding ecd-1 larvae maintained at restrictive temperature on 20-hydroxyecdysone-yeast mixture for 16 hr triggered abortive pupariation.	Ecdysterone	127-145	ecdysoneless	Drosophila melanogaster	73-78
6146468-2	1984	Ecdysterone produced an increase of AChE in rat brain slices.	Ecdysterone	0-11	acetylcholinesterase	Rattus norvegicus	36-40
6146468-5	1984	Pretreatment with cycloheximide or actinomycin D abolished the ecdysterone action on brain AChE.	Ecdysterone	63-74	acetylcholinesterase	Rattus norvegicus	91-95
6146468-6	1984	These results support the idea that induction of AChE may be involved in the heterophilic action of ecdysterone.	Ecdysterone	100-111	acetylcholinesterase	Rattus norvegicus	49-53
6194869-0	1983	A novel form of DOPA decarboxylase produced in drosophila cells in response to 20-hydroxyecdysone.	Ecdysterone	79-97	Dopa decarboxylase	Drosophila melanogaster	16-34
6198419-0	1983	20-hydroxyecdysone stimulates tissue-specific yolk-protein gene transcription in both male and female Drosophila.	Ecdysterone	0-18	Yolk protein 1	Drosophila melanogaster	46-58
6194869-1	1983	Two cloned derivatives of the Kc cell line of Drosophila were shown to produce DOPA decarboxylase following administration of the steroid moulting hormone 20-hydroxyecdysone.	Ecdysterone	155-173	Dopa decarboxylase	Drosophila melanogaster	79-97
6193215-3	1983	Yolk-protein synthesis, which normally occurs in the ovaries and fat bodies of females, but not in males unless stimulated with 20-hydroxy-ecdysone, is reduced.	Ecdysterone	128-147	Yolk protein 1	Drosophila melanogaster	0-12
6302276-6	1983	We demonstrated that these two recombinant phages, hybridizing preferentially with poly(A)+ RNA of ecdysterone-treated cells, contain the 5 C actin gene.	Ecdysterone	99-110	Actin 5C	Drosophila melanogaster	138-147
28305121-2	1983	Binding experiments with H3-alpha-amanitin demonstrate that the concentration of RNA polymerase II molecules increases two- to threefold within 3 h after ecdysterone treatment.	Ecdysterone	154-165	H3 clustered histone 1	Homo sapiens	25-33
6407003-1	1983	Expression of the LSP-2 and P1 genes was induced in cultured fat bodies of Drosophila third-instar larvae by supplementing the culture medium with ecdysterone.	Ecdysterone	147-158	Larval serum protein 2	Drosophila melanogaster	18-23
6407003-6	1983	Only the second method was used for the LSP-2 transcript because the earlier expression of the LSP-2 gene results in a measurable accumulation of the transcript in the fat bodies before ecdysterone supplementation.	Ecdysterone	186-197	Larval serum protein 2	Drosophila melanogaster	95-100
6302276-8	1983	Results of these experiments indicate that there is a sharp increase in the level of RNA coding for actin after ecdysterone treatment of the cell, and that there are two forms of actin-specific RNA in the D. melanogaster cells.	Ecdysterone	112-123	Actin 5C	Drosophila melanogaster	100-105
6302276-10	1983	Our results suggest that the expression of actin genes in D. melanogaster Kc 0% cells is modulated by ecdysterone.	Ecdysterone	102-113	Actin 5C	Drosophila melanogaster	43-48
6801663-5	1982	Hybridization of a nick-translated genomic clone containing the hsp23 gene to a total RNA blot showed that ecdysterone stimulation of hsp23 synthesis was the result of an increase in the hsp23 RNA content of S3 cells.	Ecdysterone	107-118	Heat shock protein 23	Drosophila melanogaster	64-69
6416767-3	1983	The yolk protein genes (YP genes), normally not transcribed in males, become expressed when males are injected with or fed 20-hydroxyecdysone.	Ecdysterone	123-141	Yolk protein 1	Drosophila melanogaster	4-16
6801663-5	1982	Hybridization of a nick-translated genomic clone containing the hsp23 gene to a total RNA blot showed that ecdysterone stimulation of hsp23 synthesis was the result of an increase in the hsp23 RNA content of S3 cells.	Ecdysterone	107-118	Heat shock protein 23	Drosophila melanogaster	134-139
6801663-5	1982	Hybridization of a nick-translated genomic clone containing the hsp23 gene to a total RNA blot showed that ecdysterone stimulation of hsp23 synthesis was the result of an increase in the hsp23 RNA content of S3 cells.	Ecdysterone	107-118	Heat shock protein 23	Drosophila melanogaster	134-139
6818315-5	1982	Ecdysterone increases the levels of at least three of the four LSP transcripts in the fat bodies when ecdysterone-deficient larvae from the temperature-sensitive mutant ecd1 are supplemented with the hormone.	Ecdysterone	102-113	ecdysoneless	Drosophila melanogaster	169-173
16593141-14	1982	A quantitative assay of hormone-receptor complex in K(c) cells before and after hormone stimulation showed that ecdysterone does not regulate the synthesis and the available amount of its receptor.	Ecdysterone	112-123	Adipokinetic hormone receptor	Drosophila melanogaster	24-40
6800787-2	1982	Ecdysterone (20-hydroxyecdysone), a hormonal steroid of critical importance in insect physiology, induces catalase activity in the sensitive clones.	Ecdysterone	0-11	Catalase	Drosophila melanogaster	106-114
6800787-2	1982	Ecdysterone (20-hydroxyecdysone), a hormonal steroid of critical importance in insect physiology, induces catalase activity in the sensitive clones.	Ecdysterone	13-31	Catalase	Drosophila melanogaster	106-114
6776639-0	1980	Acetylcholinesterase induction by beta-ecdysone in Drosophila cell lines and their hybrids.	Ecdysterone	34-47	Acetylcholine esterase	Drosophila melanogaster	0-20
6776639-1	1980	Drosophila S3 line cells maintain a high basal level of acetylcholinesterase (AChE) activity, which is lost and then reinduced following exposure to the steroid, beta-ecdysone.	Ecdysterone	162-175	Acetylcholine esterase	Drosophila melanogaster	56-76
6776639-1	1980	Drosophila S3 line cells maintain a high basal level of acetylcholinesterase (AChE) activity, which is lost and then reinduced following exposure to the steroid, beta-ecdysone.	Ecdysterone	162-175	Acetylcholine esterase	Drosophila melanogaster	78-82
6776639-5	1980	MDER line cells, which continue to grow in the presence of beta-ecdysone and are therefore termed resistant, show a low basal AChE level that is not further elevated by hormone.	Ecdysterone	59-72	Acetylcholine esterase	Drosophila melanogaster	126-130
223546-0	1979	Effect of ecdysterone on cyclic AMP and cyclic GMP in mouse plasma.	Ecdysterone	10-21	5'-nucleotidase, cytosolic II	Mus musculus	47-50
7348598-6	1980	These results are discussed in terms of a model in which beta-ecdysone affects the distribution of tubulin in "assembly-active" and "assembly-inactive" pools.	Ecdysterone	57-70	beta-Tubulin at 85D	Drosophila melanogaster	99-106
6776524-0	1980	Induction of translatable mRNA for dopa decarboxylase in Drosophila: an early response to ecdysterone.	Ecdysterone	90-101	Dopa decarboxylase	Drosophila melanogaster	35-53
6776524-5	1980	To obtain evidence that ecdysterone induces the appearance of this mRNA we made use of the temperature-sensitive ecd1 mutant.	Ecdysterone	24-35	ecdysoneless	Drosophila melanogaster	113-117
6776524-14	1980	In addition, a parallel increase in translatable dopa decarboxylase mRNA occurs, which may be a primary response of these target cells to ecdysterone.	Ecdysterone	138-149	Dopa decarboxylase	Drosophila melanogaster	49-67
11945974-0	1971	Inhibitory effects of alpha-amanitin on RNA synthesis and induction of DOPA-decarboxylase by beta-ecdysone.	Ecdysterone	93-106	dopa decarboxylase	Homo sapiens	71-89
877552-0	1977	Induction of acetylcholinesterase activity by beta-ecdysone in a Drosophila cell line.	Ecdysterone	46-59	Acetylcholine esterase	Drosophila melanogaster	13-33
877552-1	1977	When cells of the Drosophila Kc-H line are treated with larger than or equal to 10(-8) molar beta-ecdysone, they extend long processes and acquire acetylcholinesterase activity.	Ecdysterone	93-106	Acetylcholine esterase	Drosophila melanogaster	147-167
33876419-0	2021	beta-Ecdysone attenuates cartilage damage in a mouse model of collagenase-induced osteoarthritis via mediating FOXO1/ADAMTS-4/5 signaling axis.	Ecdysterone	0-13	forkhead box O1	Mus musculus	111-116
33878320-9	2021	Interestingly, 20-HE revealed proapoptotic activity in MDA-MB-231 and T-47D cells that was manifested by alterations in PARP, Bax, and Bcl-2 levels as well as caspase-3 activation.	Ecdysterone	15-20	collagen type XI alpha 2 chain	Homo sapiens	120-124
33878320-9	2021	Interestingly, 20-HE revealed proapoptotic activity in MDA-MB-231 and T-47D cells that was manifested by alterations in PARP, Bax, and Bcl-2 levels as well as caspase-3 activation.	Ecdysterone	15-20	BCL2 associated X, apoptosis regulator	Homo sapiens	126-129
33878320-9	2021	Interestingly, 20-HE revealed proapoptotic activity in MDA-MB-231 and T-47D cells that was manifested by alterations in PARP, Bax, and Bcl-2 levels as well as caspase-3 activation.	Ecdysterone	15-20	BCL2 apoptosis regulator	Homo sapiens	135-140
33878320-9	2021	Interestingly, 20-HE revealed proapoptotic activity in MDA-MB-231 and T-47D cells that was manifested by alterations in PARP, Bax, and Bcl-2 levels as well as caspase-3 activation.	Ecdysterone	15-20	caspase 3	Homo sapiens	159-168
33878320-10	2021	Moreover, 20-HE induced autophagy that was mediated by modification of autophagy-associated proteins, i.e., LC3, p62, and mTOR, but only in MDA-MB-231 cells.	Ecdysterone	10-15	nucleoporin 62	Homo sapiens	113-116
33878320-10	2021	Moreover, 20-HE induced autophagy that was mediated by modification of autophagy-associated proteins, i.e., LC3, p62, and mTOR, but only in MDA-MB-231 cells.	Ecdysterone	10-15	mechanistic target of rapamycin kinase	Homo sapiens	122-126
33876419-1	2021	BACKGROUND: beta-Ecdysone has been reported to perform a protective effect to prevent interleukin 1beta (IL-1beta)-induced apoptosis and inflammatory response in chondrocytes.	Ecdysterone	12-25	interleukin 1 beta	Mus musculus	86-103
33876419-1	2021	BACKGROUND: beta-Ecdysone has been reported to perform a protective effect to prevent interleukin 1beta (IL-1beta)-induced apoptosis and inflammatory response in chondrocytes.	Ecdysterone	12-25	interleukin 1 alpha	Mus musculus	105-113
33876419-12	2021	However, beta-Ecdysone treatment was able to rescue FOXO1 protein expression in the nucleus to inhibit the transcription and translation of a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (ADAMTS-4) and ADAMTS-5.	Ecdysterone	9-22	forkhead box O1	Mus musculus	52-57
33876419-12	2021	However, beta-Ecdysone treatment was able to rescue FOXO1 protein expression in the nucleus to inhibit the transcription and translation of a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (ADAMTS-4) and ADAMTS-5.	Ecdysterone	9-22	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Mus musculus	140-233
33876419-0	2021	beta-Ecdysone attenuates cartilage damage in a mouse model of collagenase-induced osteoarthritis via mediating FOXO1/ADAMTS-4/5 signaling axis.	Ecdysterone	0-13	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Mus musculus	117-127
33876419-12	2021	However, beta-Ecdysone treatment was able to rescue FOXO1 protein expression in the nucleus to inhibit the transcription and translation of a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (ADAMTS-4) and ADAMTS-5.	Ecdysterone	9-22	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Mus musculus	235-243
33876419-12	2021	However, beta-Ecdysone treatment was able to rescue FOXO1 protein expression in the nucleus to inhibit the transcription and translation of a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (ADAMTS-4) and ADAMTS-5.	Ecdysterone	9-22	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	249-257
33632227-2	2021	Kr-h1 can also be induced by molting hormone 20-hydroxyecdysone (20E), however, the underlying mechanism of 20E-induced Kr-h1 expression remains unclear.	Ecdysterone	45-63	Kruppel homolog 1	Bombyx mori	0-5
33876419-13	2021	CONCLUSION: The findings suggested that beta-Ecdysone functioned as a FOXO1 activator to protect collagenase-induced cartilage damage.	Ecdysterone	40-53	forkhead box O1	Mus musculus	70-75
33876419-14	2021	FOXO1 might be a potential molecular target of beta-Ecdysone for the effective prevention and treatment of OA.	Ecdysterone	47-60	forkhead box O1	Mus musculus	0-5
33759363-0	2021	Analytical strategy for the detection of ecdysterone and its metabolites in vivo in uPA(+/+)-SCID mice with humanised liver, human urine samples and estimation of prevalence of its use in anti-doping samples.	Ecdysterone	41-52	proline-rich acidic protein 1	Mus musculus	84-87
33632227-2	2021	Kr-h1 can also be induced by molting hormone 20-hydroxyecdysone (20E), however, the underlying mechanism of 20E-induced Kr-h1 expression remains unclear.	Ecdysterone	65-68	Kruppel homolog 1	Bombyx mori	0-5
33632227-2	2021	Kr-h1 can also be induced by molting hormone 20-hydroxyecdysone (20E), however, the underlying mechanism of 20E-induced Kr-h1 expression remains unclear.	Ecdysterone	108-111	Kruppel homolog 1	Bombyx mori	0-5
33632227-2	2021	Kr-h1 can also be induced by molting hormone 20-hydroxyecdysone (20E), however, the underlying mechanism of 20E-induced Kr-h1 expression remains unclear.	Ecdysterone	108-111	Kruppel homolog 1	Bombyx mori	120-125
33430924-4	2021	Because current therapeutic options for COVID-19 patients are limited specifically for this elderly population at risk, Biophytis is developing BIO101 (20-hydroxyecdysone, a Mas receptor activator) as a new treatment option for managing patients with SARS-CoV-2 infection at the severe stage.	Ecdysterone	152-170	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	174-186
33609783-5	2021	We also propose that the new MasR activator BIO101, a pharmaceutical grade formulation of 20-hydroxyecdysone that has anti-inflammatory, anti-fibrotic and cardioprotective properties, could restore RAS balance and improve the health of COVID-19 patients who have severe pneumonia.	Ecdysterone	90-108	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	29-33
33430924-8	2021	We propose that RAS balance could be restored in COVID-19 patients through MasR activation downstream of ACE2 activity, with 20-hydroxyecdysone (BIO101) a non-peptidic Mas receptor (MasR) activator.	Ecdysterone	125-143	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	168-180
33430924-8	2021	We propose that RAS balance could be restored in COVID-19 patients through MasR activation downstream of ACE2 activity, with 20-hydroxyecdysone (BIO101) a non-peptidic Mas receptor (MasR) activator.	Ecdysterone	125-143	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	182-186
33430924-9	2021	Indeed, MasR activation by 20-hydroxyecdysone harbours anti-inflammatory, anti-thrombotic, and anti-fibrotic properties.	Ecdysterone	27-45	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	8-12
33420323-3	2021	The current work describes the molecular mechanism employed by the Negative ELongation Factor (NELF) to control the Pol II pause at genes whose transcription is induced by 20-hydroxyecdysone (20E).	Ecdysterone	172-190	Negative elongation factor E	Drosophila melanogaster	67-93
33420323-3	2021	The current work describes the molecular mechanism employed by the Negative ELongation Factor (NELF) to control the Pol II pause at genes whose transcription is induced by 20-hydroxyecdysone (20E).	Ecdysterone	172-190	Negative elongation factor E	Drosophila melanogaster	95-99
33420323-3	2021	The current work describes the molecular mechanism employed by the Negative ELongation Factor (NELF) to control the Pol II pause at genes whose transcription is induced by 20-hydroxyecdysone (20E).	Ecdysterone	172-190	RNA polymerase II 215kD subunit	Drosophila melanogaster	116-122
32773037-3	2020	Here, we show 20-Hydroxy-Ecdysone (20HE)-signaling controlling organ homeostasis with physiological and pathological implications.	Ecdysterone	35-39	ecdysoneless	Drosophila melanogaster	25-33
33066376-0	2020	BmFoxO Gene Regulation of the Cell Cycle Induced by 20-Hydroxyecdysone in BmN-SWU1 Cells.	Ecdysterone	52-70	fkhr	Bombyx mori	0-6
33066376-3	2020	In this study, we demonstrated that the BmFoxO gene participates in the regulation of the cell cycle induced by 20-Hydroxyecdysone (20E) in BmN-SWU1 cells.	Ecdysterone	112-130	fkhr	Bombyx mori	40-46
33066376-3	2020	In this study, we demonstrated that the BmFoxO gene participates in the regulation of the cell cycle induced by 20-Hydroxyecdysone (20E) in BmN-SWU1 cells.	Ecdysterone	132-135	fkhr	Bombyx mori	40-46
33115752-2	2020	The broad (br) Z2 isoform encodes a transcription factor required for disc morphogenesis in response to 20-hydroxyecdysone, yet how it accomplishes this remains largely unknown.	Ecdysterone	104-122	broad	Drosophila melanogaster	4-17
33089948-2	2021	Previous studies have shown that 20E-induced let-7 exhibits crosstalk with cell cycle.	Ecdysterone	33-36	let-7	Drosophila melanogaster	45-50
33089948-3	2021	Here, we examined the underlying molecular mechanisms and physiological functions of 20E-induced let-7 in the fat body, an organ for energy storage and nutrient mobilization that plays a critical role in the larval growth.	Ecdysterone	85-88	let-7	Drosophila melanogaster	97-102
33089948-3	2021	Here, we examined the underlying molecular mechanisms and physiological functions of 20E-induced let-7 in the fat body, an organ for energy storage and nutrient mobilization that plays a critical role in the larval growth.	Ecdysterone	85-88	fat	Drosophila melanogaster	110-113
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	221-239	G protein-coupled estrogen receptor 1	Homo sapiens	69-106
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	221-239	G protein-coupled estrogen receptor 1	Homo sapiens	108-113
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	221-239	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	156-185
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	221-239	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	187-193
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	241-244	G protein-coupled estrogen receptor 1	Homo sapiens	69-106
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	241-244	G protein-coupled estrogen receptor 1	Homo sapiens	108-113
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	241-244	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	156-185
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	241-244	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	187-193
32237032-6	2020	Also, the level of 20-hydroxyecdysone (20E) and mRNA levels of the 20E signaling pathway-related genes EcR, USP, E74, E75 and Ftz-f1 were significantly reduced.	Ecdysterone	19-37	nuclear hormone receptor FTZ-F1	Bombyx mori	126-132
32573769-3	2020	We found that several genes encoding enzymes (E1, E2, and E3) for ubiquitination and SUMO-specific protease were upregulated by 20-hydroxyecdysone (20E), and, consistently, increases in ubiquitinated proteins were observed during the fourth molting stage.	Ecdysterone	128-146	ubiquitin-like protein SMT3	Bombyx mori	85-89
32573769-5	2020	The expression of the fibroin heavy-chain gene (fibH) was simultaneously suppressed approximately one day earlier in 20E-injected larvae.	Ecdysterone	117-120	fibroin heavy chain	Bombyx mori	48-52
32560131-2	2020	The broad complex (BrC) is a transcription factor mediating 20-hydroxyecdysone action, which plays important roles during metamorphosis.	Ecdysterone	60-78	broad-complex	Bombyx mori	19-22
31605000-6	2019	Also, we showed a molting hormone, 20-hydroxyecdysone, leads not only generation of superoxide but also downregulation of the expression of BmSOD proteins during pupation in B. mori.	Ecdysterone	35-53	superoxide dismutase [Cu-Zn]	Bombyx mori	140-145
32556319-1	2020	Bombyx mori vitellogenin (BmVg) is highly upregulated during pupation, and the 20-hydroxyecdysone and amino acids may regulate stage-specific BmVg expression.	Ecdysterone	79-97	vitellogenin	Bombyx mori	12-24
32277029-4	2020	During Bombyx larval molt or Drosophila pupariation, high levels of 20E activate AMPK, a molecular sensor that maintains energy homeostasis in the insect fat body.	Ecdysterone	68-71	AMP-activated protein kinase alpha subunit	Drosophila melanogaster	81-85
31840914-4	2020	In this study, the regulatory mechanism of Bombyx mori CBP (BmCBP) expression induced by 20-hydroxyecdysone (20E) was investigated.	Ecdysterone	89-107	carotenoid-binding protein	Bombyx mori	60-65
30266830-6	2018	We identify the trachea and the insulin-producing cells in the brain as direct targets through which 20-hydroxyecdysone regulates insulin signalling.	Ecdysterone	101-119	Insulin-like receptor	Drosophila melanogaster	32-39
31295549-7	2019	The 20-hydroxyecdysone treatment of both the Drosophila larvae and the S2 cells decreased transcriptional levels of ERR targets.	Ecdysterone	4-22	estrogen-related receptor	Drosophila melanogaster	116-119
30664184-7	2019	Beclin-1, an indispensable protein for the stimulation of autophagy, is upregulated and stabilized by beta-ecdysterone in a dose- and time-dependent manner in nucleus pulposus cells.	Ecdysterone	102-118	beclin 1	Rattus norvegicus	0-8
30834617-1	2019	A heterodimer of ultraspiracle (USP) and ecdysone receptor (EcR) mediates 20-hydroxyecdysone (20E) signalling cascade to regulate insect moulting and metamorphosis.	Ecdysterone	74-92	ultraspiracle	Drosophila melanogaster	32-35
31123801-1	2019	Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding.	Ecdysterone	51-62	estrogen receptor 1	Homo sapiens	158-175
31123801-1	2019	Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding.	Ecdysterone	51-62	estrogen receptor 1	Homo sapiens	177-179
30266830-6	2018	We identify the trachea and the insulin-producing cells in the brain as direct targets through which 20-hydroxyecdysone regulates insulin signalling.	Ecdysterone	101-119	Insulin-like receptor	Drosophila melanogaster	130-137
28219118-3	2018	BmATG5 and BmATG6 have been identified to mediate apoptosis following autophagy induced by 20-hydroxyecdysone and starvation in B. mori.	Ecdysterone	91-109	autophagy 5-like	Bombyx mori	0-6
30235865-4	2018	The lipoprotein vitellogenin, the synthesis of which is regulated by the two systemic hormones 20-hydroxyecdysone and juvenile hormone, is thought to be a precursor for the production of MRJPs.	Ecdysterone	95-113	vitellogenin	Apis mellifera	16-28
30235865-8	2018	We found that the expression of the mrjps (mrjp1-3) that were finally secreted in large amounts into the food jelly, in particular, were down regulated by 20-hydroxyecdysone treatment, with mrjp3 showing the highest repression value.	Ecdysterone	155-173	major royal jelly protein 1	Apis mellifera	43-48
30235865-8	2018	We found that the expression of the mrjps (mrjp1-3) that were finally secreted in large amounts into the food jelly, in particular, were down regulated by 20-hydroxyecdysone treatment, with mrjp3 showing the highest repression value.	Ecdysterone	155-173	major royal jelly protein 3	Apis mellifera	190-195
30262999-2	2018	In this study, we found that ecdysone oxidase (EO) gene, which encodes an enzyme to catalyze ecdysone (or 20-hydroxyecdysone, 20E) to 3-dehydroecdysone (3DE), was highly expressed in the mature ovaries of the domestic silkworm, Bombyx mori.	Ecdysterone	106-124	ecdysone oxidase	Bombyx mori	29-45
30262999-2	2018	In this study, we found that ecdysone oxidase (EO) gene, which encodes an enzyme to catalyze ecdysone (or 20-hydroxyecdysone, 20E) to 3-dehydroecdysone (3DE), was highly expressed in the mature ovaries of the domestic silkworm, Bombyx mori.	Ecdysterone	106-124	ecdysone oxidase	Bombyx mori	47-49
29582498-1	2018	Two Drosophila melanogaster E-twenty-six domain transcription factor isoforms (E74A and E74B) act differentially at the start of the 20-hydroxyecdysone (20E) signalling cascade to regulate larval-pupal metamorphosis.	Ecdysterone	133-151	Ecdysone-induced protein 74EF	Drosophila melanogaster	88-92
29205800-1	2018	BACKGROUND: 20-Hydroxyecdysone (20E), a crucial insect steroid hormone, can bind to its cognate nuclear receptor composed of ecdysone receptor (EcR) and ultraspiracle (USP) to activate expression of 20E-response genes, enabling subsequent metamorphosis.	Ecdysterone	12-30	ecdysone receptor	Bombyx mori	125-142
29205800-1	2018	BACKGROUND: 20-Hydroxyecdysone (20E), a crucial insect steroid hormone, can bind to its cognate nuclear receptor composed of ecdysone receptor (EcR) and ultraspiracle (USP) to activate expression of 20E-response genes, enabling subsequent metamorphosis.	Ecdysterone	12-30	ecdysone receptor	Bombyx mori	144-147
29205800-1	2018	BACKGROUND: 20-Hydroxyecdysone (20E), a crucial insect steroid hormone, can bind to its cognate nuclear receptor composed of ecdysone receptor (EcR) and ultraspiracle (USP) to activate expression of 20E-response genes, enabling subsequent metamorphosis.	Ecdysterone	12-30	protein ultraspiracle homolog	Bombyx mori	168-171
29529496-1	2018	Insect growth is regulated by the steroid hormone 20-hydroxyecdysone (20E), which works via the ecdysone receptor (EcR).	Ecdysterone	50-68	ecdysone receptor	Bombyx mori	96-113
29529496-1	2018	Insect growth is regulated by the steroid hormone 20-hydroxyecdysone (20E), which works via the ecdysone receptor (EcR).	Ecdysterone	50-68	ecdysone receptor	Bombyx mori	115-118
28843894-7	2017	On contrary, 20-hydroxyecdysone (20E) induced the expression level of Akt in TGP larvae, but at feeding only.	Ecdysterone	13-31	AKT serine/threonine kinase 1	Bos taurus	70-73
29115419-8	2018	Therefore, beta-ecdysterone may be a promising candidate drug for the treatment of osteoporosis through inducing osteoblast autophagic activity by inactivating mTOR.	Ecdysterone	11-27	mechanistic target of rapamycin kinase	Homo sapiens	160-164
29337690-4	2018	The Drosophila melanogaster peptidyl-prolyl cis-trans isomerase FK506-binding protein of 39 kDa (FKBP39) is thought to act as a transcriptional modulator of gene expression in 20-hydroxyecdysone and juvenile hormone signal transduction.	Ecdysterone	176-194	FK506-binding protein 39kD	Drosophila melanogaster	64-95
29337690-4	2018	The Drosophila melanogaster peptidyl-prolyl cis-trans isomerase FK506-binding protein of 39 kDa (FKBP39) is thought to act as a transcriptional modulator of gene expression in 20-hydroxyecdysone and juvenile hormone signal transduction.	Ecdysterone	176-194	FK506-binding protein 39kD	Drosophila melanogaster	97-103
28951206-0	2018	Leptinotarsa hormone receptor 4 (HR4) tunes ecdysteroidogenesis and mediates 20-hydroxyecdysone signaling during larval-pupal metamorphosis.	Ecdysterone	77-95	Hormone receptor 4	Drosophila melanogaster	13-31
28951206-0	2018	Leptinotarsa hormone receptor 4 (HR4) tunes ecdysteroidogenesis and mediates 20-hydroxyecdysone signaling during larval-pupal metamorphosis.	Ecdysterone	77-95	Hormone receptor 4	Drosophila melanogaster	33-36
28951206-1	2018	Hormone receptor 4 (HR4) is involved in the regulation of 20-hydroxyecdysone (20E) biosynthesis and the mediation of 20E signaling during larval-pupal transition in a holometabolan Drosophila melanogaster, whereas it acts as a repressor in 20E-responsive transcriptional cascade in a hemimetabolan, Blattella germanica.	Ecdysterone	58-76	Hormone receptor 4	Drosophila melanogaster	0-18
28951206-1	2018	Hormone receptor 4 (HR4) is involved in the regulation of 20-hydroxyecdysone (20E) biosynthesis and the mediation of 20E signaling during larval-pupal transition in a holometabolan Drosophila melanogaster, whereas it acts as a repressor in 20E-responsive transcriptional cascade in a hemimetabolan, Blattella germanica.	Ecdysterone	58-76	Hormone receptor 4	Drosophila melanogaster	20-23
28951206-1	2018	Hormone receptor 4 (HR4) is involved in the regulation of 20-hydroxyecdysone (20E) biosynthesis and the mediation of 20E signaling during larval-pupal transition in a holometabolan Drosophila melanogaster, whereas it acts as a repressor in 20E-responsive transcriptional cascade in a hemimetabolan, Blattella germanica.	Ecdysterone	78-81	Hormone receptor 4	Drosophila melanogaster	0-18
28951206-1	2018	Hormone receptor 4 (HR4) is involved in the regulation of 20-hydroxyecdysone (20E) biosynthesis and the mediation of 20E signaling during larval-pupal transition in a holometabolan Drosophila melanogaster, whereas it acts as a repressor in 20E-responsive transcriptional cascade in a hemimetabolan, Blattella germanica.	Ecdysterone	78-81	Hormone receptor 4	Drosophila melanogaster	20-23
29032156-7	2017	Administration of 20-hydroxyecdysone significantly downregulated the BmSOCS2-12 expression in fat body, and the depletion of BmSOCS2-12 enhanced the transcript levels of 20-hydroxyecdysone-responsive genes at 48 h. Altogether, BmSOCS2-12 may have multiple functional roles in the physiology of B. mori (Dazao), since it negatively regulates the expression of AMPs and ecdysteroid signaling transduction.	Ecdysterone	18-36	SOCS2-12 protein	Bombyx mori	69-79
29032156-7	2017	Administration of 20-hydroxyecdysone significantly downregulated the BmSOCS2-12 expression in fat body, and the depletion of BmSOCS2-12 enhanced the transcript levels of 20-hydroxyecdysone-responsive genes at 48 h. Altogether, BmSOCS2-12 may have multiple functional roles in the physiology of B. mori (Dazao), since it negatively regulates the expression of AMPs and ecdysteroid signaling transduction.	Ecdysterone	170-188	SOCS2-12 protein	Bombyx mori	125-135
29032156-7	2017	Administration of 20-hydroxyecdysone significantly downregulated the BmSOCS2-12 expression in fat body, and the depletion of BmSOCS2-12 enhanced the transcript levels of 20-hydroxyecdysone-responsive genes at 48 h. Altogether, BmSOCS2-12 may have multiple functional roles in the physiology of B. mori (Dazao), since it negatively regulates the expression of AMPs and ecdysteroid signaling transduction.	Ecdysterone	170-188	SOCS2-12 protein	Bombyx mori	125-135
28720705-8	2017	The phase of diapause termination is associated with enhanced transcript levels in several positive elements stimulating direct development (the 20-hydroxyecdysone pathway: Ecr, Shd, Broad; the Wnt pathway: basket, c-jun) that are countered by up-regulation in some negative elements (the insulin-signaling pathway: Ilp8, PI3k, Akt; the target of rapamycin pathway: Tsc2 and 4EBP; the Wnt pathway: shaggy).	Ecdysterone	145-163	Jun-related antigen	Drosophila melanogaster	215-220
28621470-0	2017	The POU homeodomain transcription factor POUM2 and broad complex isoform 2 transcription factor induced by 20-hydroxyecdysone collaboratively regulate vitellogenin gene expression and egg formation in the silkworm Bombyx mori.	Ecdysterone	107-125	silk gland factor 3	Bombyx mori	41-46
28621470-0	2017	The POU homeodomain transcription factor POUM2 and broad complex isoform 2 transcription factor induced by 20-hydroxyecdysone collaboratively regulate vitellogenin gene expression and egg formation in the silkworm Bombyx mori.	Ecdysterone	107-125	vitellogenin	Bombyx mori	151-163
28621470-2	2017	Our previous study showed that the silkworm (Bombyx mori) transcription factor broad complex isoform 2 (BmBrC-Z2) regulates gene expression of the Vg gene (BmVg) by induction with 20-hydroxyecdysone (20E).	Ecdysterone	180-198	vitellogenin	Bombyx mori	147-149
28390932-0	2017	20-hydroxyecdysone positively regulates the transcription of the antimicrobial peptide, lebocin, via BmEts and BmBR-C Z4 in the midgut of Bombyx mori during metamorphosis.	Ecdysterone	0-18	transcription factor Ets	Bombyx mori	101-106
28720705-8	2017	The phase of diapause termination is associated with enhanced transcript levels in several positive elements stimulating direct development (the 20-hydroxyecdysone pathway: Ecr, Shd, Broad; the Wnt pathway: basket, c-jun) that are countered by up-regulation in some negative elements (the insulin-signaling pathway: Ilp8, PI3k, Akt; the target of rapamycin pathway: Tsc2 and 4EBP; the Wnt pathway: shaggy).	Ecdysterone	145-163	Insulin-like peptide 8	Drosophila melanogaster	316-320
28720705-8	2017	The phase of diapause termination is associated with enhanced transcript levels in several positive elements stimulating direct development (the 20-hydroxyecdysone pathway: Ecr, Shd, Broad; the Wnt pathway: basket, c-jun) that are countered by up-regulation in some negative elements (the insulin-signaling pathway: Ilp8, PI3k, Akt; the target of rapamycin pathway: Tsc2 and 4EBP; the Wnt pathway: shaggy).	Ecdysterone	145-163	Akt1	Drosophila melanogaster	328-331
28720705-8	2017	The phase of diapause termination is associated with enhanced transcript levels in several positive elements stimulating direct development (the 20-hydroxyecdysone pathway: Ecr, Shd, Broad; the Wnt pathway: basket, c-jun) that are countered by up-regulation in some negative elements (the insulin-signaling pathway: Ilp8, PI3k, Akt; the target of rapamycin pathway: Tsc2 and 4EBP; the Wnt pathway: shaggy).	Ecdysterone	145-163	gigas	Drosophila melanogaster	366-379
28373010-10	2017	Brain tissue western blots of ecdysterone-treated rats showed upregulated PI3K, Akt, mTOR, and phosphorylated Akt and mTOR, and down regulated GRIN2B and the apoptotic enzyme cleaved caspase-3.	Ecdysterone	30-41	AKT serine/threonine kinase 1	Rattus norvegicus	80-83
28676356-3	2017	Analysis of mRNA level showed that BmCHSA-2b was responsive to 20-hydroxyecdysone (20E) in pupal wing unlike BmCHSA-2a, which shares almost the identical sequence as BmCHSA-2b except the first 31 amino acids, suggesting that the expression of these two alternative splicing variants is driven by different promoters of CHSA gene.	Ecdysterone	63-81	chitin synthase A	Bombyx mori	37-41
28388784-9	2017	Meanwhile, beta-ecdysone inhibited glucocorticoid function, preserving the expression of Akt1 and phospho-Akt and reducing the expression of transformation-related protein 53, ataxia telangiectasia mutated protein, caspase-3, and caspase-8.	Ecdysterone	11-24	thymoma viral proto-oncogene 1	Mus musculus	89-93
28388784-9	2017	Meanwhile, beta-ecdysone inhibited glucocorticoid function, preserving the expression of Akt1 and phospho-Akt and reducing the expression of transformation-related protein 53, ataxia telangiectasia mutated protein, caspase-3, and caspase-8.	Ecdysterone	11-24	thymoma viral proto-oncogene 1	Mus musculus	89-92
28388784-9	2017	Meanwhile, beta-ecdysone inhibited glucocorticoid function, preserving the expression of Akt1 and phospho-Akt and reducing the expression of transformation-related protein 53, ataxia telangiectasia mutated protein, caspase-3, and caspase-8.	Ecdysterone	11-24	transformation related protein 53	Mus musculus	141-174
28388784-9	2017	Meanwhile, beta-ecdysone inhibited glucocorticoid function, preserving the expression of Akt1 and phospho-Akt and reducing the expression of transformation-related protein 53, ataxia telangiectasia mutated protein, caspase-3, and caspase-8.	Ecdysterone	11-24	caspase 3	Mus musculus	215-224
28388784-9	2017	Meanwhile, beta-ecdysone inhibited glucocorticoid function, preserving the expression of Akt1 and phospho-Akt and reducing the expression of transformation-related protein 53, ataxia telangiectasia mutated protein, caspase-3, and caspase-8.	Ecdysterone	11-24	caspase 8	Mus musculus	230-239
28373010-10	2017	Brain tissue western blots of ecdysterone-treated rats showed upregulated PI3K, Akt, mTOR, and phosphorylated Akt and mTOR, and down regulated GRIN2B and the apoptotic enzyme cleaved caspase-3.	Ecdysterone	30-41	mechanistic target of rapamycin kinase	Rattus norvegicus	85-89
28373010-10	2017	Brain tissue western blots of ecdysterone-treated rats showed upregulated PI3K, Akt, mTOR, and phosphorylated Akt and mTOR, and down regulated GRIN2B and the apoptotic enzyme cleaved caspase-3.	Ecdysterone	30-41	AKT serine/threonine kinase 1	Rattus norvegicus	110-113
28373010-10	2017	Brain tissue western blots of ecdysterone-treated rats showed upregulated PI3K, Akt, mTOR, and phosphorylated Akt and mTOR, and down regulated GRIN2B and the apoptotic enzyme cleaved caspase-3.	Ecdysterone	30-41	mechanistic target of rapamycin kinase	Rattus norvegicus	118-122
28373010-10	2017	Brain tissue western blots of ecdysterone-treated rats showed upregulated PI3K, Akt, mTOR, and phosphorylated Akt and mTOR, and down regulated GRIN2B and the apoptotic enzyme cleaved caspase-3.	Ecdysterone	30-41	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	143-149
28245983-4	2017	20-hydroxyecdysone induced Drosophila cg6568 transcription both in vitro and in vivo.	Ecdysterone	0-18	Cathelicidin-like antimicrobial protein	Drosophila melanogaster	38-44
28397606-6	2017	Hemolymph titers of 20-hydroxyecdysone were very low in the last two days of the pupal period.	Ecdysterone	20-38	period	Drosophila melanogaster	87-93
27871792-0	2017	Dual inhibition of BACE1 and Abeta aggregation by beta-ecdysone: Application of a phytoecdysteroid scaffold in Alzheimer"s disease therapeutics.	Ecdysterone	50-63	beta-secretase 1	Homo sapiens	19-24
27871792-3	2017	beta-ecdysone strongly binds to the active site cavity of BACE1 with calculated dissociation constant of 1.75+-0.1muM.	Ecdysterone	0-13	beta-secretase 1	Homo sapiens	58-63