PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33939580-3	2021	In alpha-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC50 range of 9.17-97.53 microM, as compared with that of the positive control acarbose (249 microM).	biflavone	77-86	sucrase-isomaltase	Homo sapiens	3-20
19041241-1	2009	In order to establish anti-inflammatory potential of biflavonoids, 17 biflavone derivatives having a 6-O-7"" linkage were synthesized and their effects on cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were evaluated.	biflavone	70-79	prostaglandin-endoperoxide synthase 2	Mus musculus	173-178
33854174-0	2021	Identification and functional analysis of a biflavone as a novel inhibitor of transient receptor potential vanilloid 4-dependent atherogenic processes.	biflavone	44-53	transient receptor potential cation channel subfamily V member 4	Homo sapiens	78-118
33854174-4	2021	Herein, using a fluorometric imaging plate reader-supported Ca2+ influx assay, we report semi high-throughput screening-based identification of ginkgetin, a biflavone, as a novel inhibitor of transient receptor potential vanilloid 4 (TRPV4)-dependent proatherogenic and inflammatory processes in macrophages.	biflavone	157-166	transient receptor potential cation channel subfamily V member 4	Homo sapiens	192-232
33854174-4	2021	Herein, using a fluorometric imaging plate reader-supported Ca2+ influx assay, we report semi high-throughput screening-based identification of ginkgetin, a biflavone, as a novel inhibitor of transient receptor potential vanilloid 4 (TRPV4)-dependent proatherogenic and inflammatory processes in macrophages.	biflavone	157-166	transient receptor potential cation channel subfamily V member 4	Homo sapiens	234-239
33571798-0	2021	Exploring the efficacy of naturally occurring biflavone based antioxidants towards the inhibition of the SARS-CoV-2 spike glycoprotein mediated membrane fusion.	biflavone	46-55	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	116-121
33571798-1	2021	Molecular docking studies were done to show the inhibitory effect of two naturally occurring biflavone based anti-HIV agents, hinokiflavone and robustaflavone against the SARS-CoV-2 spike (S) protein mediated attack on the human ACE2 receptors via membrane fusion mechanism.	biflavone	93-102	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	182-187
33571798-1	2021	Molecular docking studies were done to show the inhibitory effect of two naturally occurring biflavone based anti-HIV agents, hinokiflavone and robustaflavone against the SARS-CoV-2 spike (S) protein mediated attack on the human ACE2 receptors via membrane fusion mechanism.	biflavone	93-102	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	171-172
33571798-1	2021	Molecular docking studies were done to show the inhibitory effect of two naturally occurring biflavone based anti-HIV agents, hinokiflavone and robustaflavone against the SARS-CoV-2 spike (S) protein mediated attack on the human ACE2 receptors via membrane fusion mechanism.	biflavone	93-102	angiotensin converting enzyme 2	Homo sapiens	229-233
30472463-3	2019	Here, we demonstrated a novel role of ginkgetin, a biflavone from Ginkgo biloba leaves, as a STAT5 inhibitor that blocks the differentiation of preadipocytes into adipocytes.	biflavone	51-60	signal transducer and activator of transcription 5A	Mus musculus	93-98
27082979-4	2016	Bischromone 10 and biflavone 13 both promoted the mammalian TNF-alpha signaling pathway and Drosophila innate immunity.	biflavone	19-28	tumor necrosis factor	Homo sapiens	60-69