PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23428130-9	2013	The immunohistochemical results showed that phosphor-dynamin-1 was highly expressed in the cytoplasm of hippocampal neurons of AC, CC and HC groups, but its expression was significantly reduced in the AS, CS and HM groups (P<0.05).	His-Met	212-214	dynamin 1	Homo sapiens	53-62
28188730-8	2017	KEY FINDINGS: The unstable plaque formation and lesion apoptotic cells are increased in ApoE-/- mice supplemented with high-methionine (HM), accompanied with a decreased expression of histone H3 lysine 9 dimethylation.	His-Met	136-138	apolipoprotein E	Mus musculus	88-92
26806788-4	2016	RESULTS: The average number of ZNF469 non-synonymous variants was 16.31 and 16.0 for individuals with KTCN and HM, respectively (p = 0.3724).	His-Met	111-113	zinc finger protein 469	Homo sapiens	31-37
26035067-10	2015	Treatment with HM inhibited HG-induced oxidative stress by suppressing hydroxyl and ONOO- production, levels of 8-OHdG, caspase-3 activity and apoptosis in the SCs.	His-Met	15-17	caspase 3	Homo sapiens	120-129
27067455-18	2016	Using fluorescently labelled C1-3 we can assess HM numbers in the injured liver and monitor response to therapy.	His-Met	48-50	Rho GTPase activating protein 4	Mus musculus	29-33
26757632-8	2015	RESULTS: IL-17 expression in periodontal ligament showed more positively in PM and RM groups compared with NC, PC and HM groups.	His-Met	118-120	interleukin 17A	Rattus norvegicus	9-14
21310961-5	2011	In HEK293T cells, insulin and constitutively active mutants of small GTPase H-Ras and PI3K could induce HM phosphorylation of both AKT mutants, which was blocked by the PI3K inhibitor LY294002.	His-Met	104-106	insulin	Homo sapiens	18-25
21562092-8	2011	In -10066 G/G homozygotes, serum adiponectin increased with age after the HM diet and decreased after the LF diet.	His-Met	74-76	adiponectin, C1Q and collagen domain containing	Homo sapiens	33-44
21310961-5	2011	In HEK293T cells, insulin and constitutively active mutants of small GTPase H-Ras and PI3K could induce HM phosphorylation of both AKT mutants, which was blocked by the PI3K inhibitor LY294002.	His-Met	104-106	HRas proto-oncogene, GTPase	Homo sapiens	76-81
21310961-5	2011	In HEK293T cells, insulin and constitutively active mutants of small GTPase H-Ras and PI3K could induce HM phosphorylation of both AKT mutants, which was blocked by the PI3K inhibitor LY294002.	His-Met	104-106	AKT serine/threonine kinase 1	Homo sapiens	131-134
19103478-9	2009	We suggest that HM can modulate the inflammatory response by inducing IL-8 and IL-6 production via TLR4-dependent activation of the NF-kappaB signaling pathway.	His-Met	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
19103478-9	2009	We suggest that HM can modulate the inflammatory response by inducing IL-8 and IL-6 production via TLR4-dependent activation of the NF-kappaB signaling pathway.	His-Met	16-18	interleukin 6	Homo sapiens	79-83
19103478-9	2009	We suggest that HM can modulate the inflammatory response by inducing IL-8 and IL-6 production via TLR4-dependent activation of the NF-kappaB signaling pathway.	His-Met	16-18	toll like receptor 4	Homo sapiens	99-103
34447474-3	2021	However, the potential effect of HM on the production of interleukin-1beta (IL-1beta), the main immunoregulatory cytokine secreted by activated monocytes, has not been reported.	His-Met	33-35	interleukin 1 beta	Homo sapiens	57-74
19056240-11	2009	Decreases in Bax expression, increases in B-cell lymphoma-2 expression, decreases in apoptotic cell number, and amelioration of histopathologic findings were observed in livers of rats fed with the taurine plus HM diet.	His-Met	211-213	BCL2 associated X, apoptosis regulator	Rattus norvegicus	13-16
19191559-10	2009	Milk fat from DOHM contained a greater concentration of cis-9,trans-11 conjugated linoleic acid (CLA, 16.4 vs 11.6 mg/100 mL of milk, DOHM vs HM, respectively).	His-Met	16-18	Weaning weight-maternal milk	Bos taurus	0-4
17113648-8	2007	The HM band possessed most of the DBP binding activity (58%), and activation of cells with ionomycin greatly increased DBP binding to HM.	His-Met	4-6	D-box binding PAR bZIP transcription factor	Homo sapiens	34-37
17113648-8	2007	The HM band possessed most of the DBP binding activity (58%), and activation of cells with ionomycin greatly increased DBP binding to HM.	His-Met	4-6	D-box binding PAR bZIP transcription factor	Homo sapiens	119-122
30006087-6	2018	Both species, dWSP and HM-dWSP, were tested in LAN5 and NIH 3T3 model cells to study their biological effect.	His-Met	23-25	WASp	Drosophila melanogaster	26-30
16650380-3	2006	We used HM and LPS in parallel to induce IL-8 production by THP-I, PBMCs, and TLR4-transfected HEK293 cells.	His-Met	8-10	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
16650380-3	2006	We used HM and LPS in parallel to induce IL-8 production by THP-I, PBMCs, and TLR4-transfected HEK293 cells.	His-Met	8-10	toll like receptor 4	Homo sapiens	78-82
16650380-5	2006	On applying similar treatment to HEK293 cells that express TLR4, MD2, and CD14, both HM and LPS significantly induced IL-8 protein production.	His-Met	85-87	toll like receptor 4	Homo sapiens	59-63
16650380-5	2006	On applying similar treatment to HEK293 cells that express TLR4, MD2, and CD14, both HM and LPS significantly induced IL-8 protein production.	His-Met	85-87	lymphocyte antigen 96	Homo sapiens	65-68
16650380-5	2006	On applying similar treatment to HEK293 cells that express TLR4, MD2, and CD14, both HM and LPS significantly induced IL-8 protein production.	His-Met	85-87	CD14 molecule	Homo sapiens	74-78
16650380-5	2006	On applying similar treatment to HEK293 cells that express TLR4, MD2, and CD14, both HM and LPS significantly induced IL-8 protein production.	His-Met	85-87	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
16650380-6	2006	We have also demonstrated that HM and LPS had identical effects in terms of IL-8 stimulation by HEK293 transfected with either TLR4 or MD2-CD14.	His-Met	31-33	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
16650380-6	2006	We have also demonstrated that HM and LPS had identical effects in terms of IL-8 stimulation by HEK293 transfected with either TLR4 or MD2-CD14.	His-Met	31-33	toll like receptor 4	Homo sapiens	127-131
16650380-6	2006	We have also demonstrated that HM and LPS had identical effects in terms of IL-8 stimulation by HEK293 transfected with either TLR4 or MD2-CD14.	His-Met	31-33	lymphocyte antigen 96	Homo sapiens	135-138
16650380-6	2006	We have also demonstrated that HM and LPS had identical effects in terms of IL-8 stimulation by HEK293 transfected with either TLR4 or MD2-CD14.	His-Met	31-33	CD14 molecule	Homo sapiens	139-143
15210586-10	2004	Interestingly, GRP78/94 and phospho-PERK were markedly increased in macrophage foam cells from early lesions of mice fed the control or the HM diet.	His-Met	140-142	heat shock protein 5	Mus musculus	15-20
15210586-10	2004	Interestingly, GRP78/94 and phospho-PERK were markedly increased in macrophage foam cells from early lesions of mice fed the control or the HM diet.	His-Met	140-142	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	36-40
10806144-6	2000	The PDE-4 inhibitor alone prevented further HM formation and infiltration of neutrophil leukocytes.	His-Met	44-46	phosphodiesterase 4A	Homo sapiens	4-9
10806144-8	2000	Based on both doses of rSP-C surfactant, addition of the PDE-4 inhibitor showed additional effects on oxygenation and inhibition of HM formation.	His-Met	132-134	phosphodiesterase 4A	Homo sapiens	57-62
34447474-3	2021	However, the potential effect of HM on the production of interleukin-1beta (IL-1beta), the main immunoregulatory cytokine secreted by activated monocytes, has not been reported.	His-Met	33-35	interleukin 1 alpha	Homo sapiens	76-84
34447474-5	2021	Signaling pathways involved in the HM-induced IL-1beta production was investigated in the THP-1 cells.	His-Met	35-37	interleukin 1 alpha	Homo sapiens	46-54
34447474-8	2021	The blockade of the p38 MAPK pathway, with the pharmacological inhibitor SB202190, and TLR2 receptor with a neutralization antibody, resulted in the decrease of HM-induced IL-1beta production in THP-1 cells.	His-Met	161-163	toll like receptor 2	Homo sapiens	87-91
34447474-8	2021	The blockade of the p38 MAPK pathway, with the pharmacological inhibitor SB202190, and TLR2 receptor with a neutralization antibody, resulted in the decrease of HM-induced IL-1beta production in THP-1 cells.	His-Met	161-163	interleukin 1 alpha	Homo sapiens	172-180
34447474-9	2021	The TLR4 receptor blockade also decreased HM-induced IL-1beta production, but to a lesser extent than TLR2 blockade.	His-Met	42-44	toll like receptor 4	Homo sapiens	4-8
34447474-9	2021	The TLR4 receptor blockade also decreased HM-induced IL-1beta production, but to a lesser extent than TLR2 blockade.	His-Met	42-44	interleukin 1 alpha	Homo sapiens	53-61
32322173-3	2020	Herbal melanin (HM) is an extract of the seed coats of Nigella sativa that modulates an inflammatory response through toll-like receptor 4 (TLR4).	His-Met	16-18	toll like receptor 4	Homo sapiens	140-144
35472740-5	2022	When compared to control and NC group, the diets with HM decreased the contents of total cholesterol and TG in liver, as well as upregulated the mRNA abundance of hepatic hormone-sensitive lipase and lipoprotein lipase.	His-Met	54-56	lipoprotein lipase	Gallus gallus	200-218
32448225-10	2020	CONCLUSION: HM exerts distinct anti-proliferative effects on human acute monocytic leukemia and embryonic kidney cells mainly through cell cycle interference in a TLR4-independent manner and through apoptosis induction in a TLR4-dependent manner, as observed in only the THP-1 cells.	His-Met	12-14	toll like receptor 4	Homo sapiens	163-167
32448225-10	2020	CONCLUSION: HM exerts distinct anti-proliferative effects on human acute monocytic leukemia and embryonic kidney cells mainly through cell cycle interference in a TLR4-independent manner and through apoptosis induction in a TLR4-dependent manner, as observed in only the THP-1 cells.	His-Met	12-14	toll like receptor 4	Homo sapiens	224-228
32448225-10	2020	CONCLUSION: HM exerts distinct anti-proliferative effects on human acute monocytic leukemia and embryonic kidney cells mainly through cell cycle interference in a TLR4-independent manner and through apoptosis induction in a TLR4-dependent manner, as observed in only the THP-1 cells.	His-Met	12-14	GLI family zinc finger 2	Homo sapiens	271-276
32322173-14	2020	TLR4 receptor downregulation enhanced HM-induced apoptosis while TLR4 receptor blockade partially alleviated HM-inhibited ERK phosphorylation.	His-Met	109-111	toll like receptor 4	Homo sapiens	65-69
32322173-14	2020	TLR4 receptor downregulation enhanced HM-induced apoptosis while TLR4 receptor blockade partially alleviated HM-inhibited ERK phosphorylation.	His-Met	109-111	mitogen-activated protein kinase 1	Homo sapiens	122-125
32322173-14	2020	TLR4 receptor downregulation enhanced HM-induced apoptosis while TLR4 receptor blockade partially alleviated HM-inhibited ERK phosphorylation.	His-Met	38-40	toll like receptor 4	Homo sapiens	0-4