PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27387499-4	2016	We have focused our attention on active-site residues of PRMT7 from the protozoan Trypanosoma brucei We have designed 26 single and double mutations in the active site, including residues in the Glu-Xaa8-Glu (double E) loop and the Met-Gln-Trp sequence of the canonical Thr-His-Trp (THW) loop known to interact with the methyl-accepting substrate arginine.	THW	283-286	protein arginine methyltransferase 7	Homo sapiens	57-62
31637953-15	2019	Conclusions: Mutation-guided MAPK pathway inhibition with MEK inhibitor or a combination of BRAF inhibitor and MEK inhibitor under concurrent THW is a feasible and a promising strategy to redifferentiate RAIR DTC, thereby rendering them suitable for RAI therapy with satisfactory retention following treatment.	THW	142-145	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	92-96
31637953-15	2019	Conclusions: Mutation-guided MAPK pathway inhibition with MEK inhibitor or a combination of BRAF inhibitor and MEK inhibitor under concurrent THW is a feasible and a promising strategy to redifferentiate RAIR DTC, thereby rendering them suitable for RAI therapy with satisfactory retention following treatment.	THW	142-145	mitogen-activated protein kinase kinase 7	Homo sapiens	111-114
29947577-6	2018	Feeding S6 or S8 to THW significantly lowered larval weight (21-37%) as well as increased expression of StPIN2 in comparison to untransformed Kennebec.	THW	20-23	proteinase inhibitor type-2	Solanum tuberosum	104-110
27387499-7	2016	Consistent with our model, the mutation of Cys-431 to His in the THW loop of human PRMT9 shifts its product specificity from SDMA toward MMA.	THW	65-68	protein arginine methyltransferase 9	Homo sapiens	83-88
24709982-7	2014	AST and ALT levels before RIT with THW were significantly higher than those before RIT with rhTSH (P<0.001).	THW	35-38	solute carrier family 17 member 5	Homo sapiens	0-3
26490048-7	2015	PCSK9 levels increased before THW and after THW in the patients compared to control group (p<0.001, p=0.004, respectively).	THW	30-33	proprotein convertase subtilisin/kexin type 9	Homo sapiens	0-5
26490048-7	2015	PCSK9 levels increased before THW and after THW in the patients compared to control group (p<0.001, p=0.004, respectively).	THW	44-47	proprotein convertase subtilisin/kexin type 9	Homo sapiens	0-5
24866576-11	2014	Also, Tg levels were lower in nonstructural disease than in structural disease in both rhTSH (3.8 vs 127.0 ng/ml, P<0.01) and THW (13.0 vs 143.5 ng/ml, P<0.0001) patients.	THW	129-132	thyroglobulin	Homo sapiens	6-8
19072673-12	2009	Insulin resistance is closely related to post-THW hypothyroidism in patients of DTC.	THW	46-49	insulin	Homo sapiens	0-7
24873669-8	2014	Gene expression levels of GAP-43, NCAM, and SYN-1 in the test groups were higher than that in thw control.	THW	94-97	growth associated protein 43	Homo sapiens	26-32
24037891-11	2013	In the THW group, Tg at ablation also proved to have independent predictive value.	THW	7-10	thyroglobulin	Homo sapiens	18-20
24037891-12	2013	Using the same threshold (7.2 ng/mL), the negative predictive value of Tg was 95% in the THW group.	THW	89-92	thyroglobulin	Homo sapiens	71-73
24900040-13	2012	Patients in the THW group had higher follow-up AST and ALT levels than did the rh-TSH group.	THW	16-19	solute carrier family 17 member 5	Homo sapiens	47-50
22978687-1	2013	BACKGROUND: The thyrotropin (TSH) level or duration of thyroid hormone withdrawal (THW) required to detect stimulated thyroglobulin (Tg) in differentiated thyroid cancer (DTC) monitoring is unknown.	THW	83-86	thyroglobulin	Homo sapiens	118-131
127164-3	1975	The change of myosin properties of thw whole cross-innervated ALD did not occur until the third month after the operation.	THW	35-38	myosin, heavy chain 15	Gallus gallus	14-20