PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25479718-10	2015	The results showed that berberine hydrochloride significantly attenuated neutrophil infiltration, suppressed myeloperoxidase activity and decreased NO, TNF-alphaand IL-1betaproduction.	berberine chloride	24-47	myeloperoxidase	Mus musculus	109-124
27601129-0	2016	p53, Bcl-2 and cox-2 are involved in berberine hydrochloride-induced apoptosis of HeLa229 cells.	berberine chloride	37-60	tumor protein p53	Homo sapiens	0-3
27601129-0	2016	p53, Bcl-2 and cox-2 are involved in berberine hydrochloride-induced apoptosis of HeLa229 cells.	berberine chloride	37-60	BCL2 apoptosis regulator	Homo sapiens	5-10
27601129-0	2016	p53, Bcl-2 and cox-2 are involved in berberine hydrochloride-induced apoptosis of HeLa229 cells.	berberine chloride	37-60	prostaglandin-endoperoxide synthase 2	Homo sapiens	15-20
27601129-5	2016	Berberine hydrochloride upregulated the mRNA expression levels of p53, and downregulated mRNA expression levels of Bcl-2 and cox-2, in a dose-dependent manner.	berberine chloride	0-23	tumor protein p53	Homo sapiens	66-69
27601129-5	2016	Berberine hydrochloride upregulated the mRNA expression levels of p53, and downregulated mRNA expression levels of Bcl-2 and cox-2, in a dose-dependent manner.	berberine chloride	0-23	BCL2 apoptosis regulator	Homo sapiens	115-120
27601129-5	2016	Berberine hydrochloride upregulated the mRNA expression levels of p53, and downregulated mRNA expression levels of Bcl-2 and cox-2, in a dose-dependent manner.	berberine chloride	0-23	prostaglandin-endoperoxide synthase 2	Homo sapiens	125-130
27601129-6	2016	In conclusion, berberine hydrochloride inhibited the proliferation and induced apoptosis of HeLa229 cells, potentially via the upregulation of p53 and the downregulation of Bcl-2 and cox-2 mRNA expression levels.	berberine chloride	15-38	tumor protein p53	Homo sapiens	143-146
27601129-6	2016	In conclusion, berberine hydrochloride inhibited the proliferation and induced apoptosis of HeLa229 cells, potentially via the upregulation of p53 and the downregulation of Bcl-2 and cox-2 mRNA expression levels.	berberine chloride	15-38	BCL2 apoptosis regulator	Homo sapiens	173-178
27601129-6	2016	In conclusion, berberine hydrochloride inhibited the proliferation and induced apoptosis of HeLa229 cells, potentially via the upregulation of p53 and the downregulation of Bcl-2 and cox-2 mRNA expression levels.	berberine chloride	15-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	183-188
27535021-0	2016	Berberine Hydrochloride Protects C2C12 Myoblast Cells Against Oxidative Stress-Induced Damage via Induction of Nrf-2-Mediated HO-1 Expression.	berberine chloride	0-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-116
27535021-0	2016	Berberine Hydrochloride Protects C2C12 Myoblast Cells Against Oxidative Stress-Induced Damage via Induction of Nrf-2-Mediated HO-1 Expression.	berberine chloride	0-23	heme oxygenase 1	Mus musculus	126-130
27535021-1	2016	Preclinical Research The aim of the present study was to evaluate the effects of berberine hydrochloride (BBH), an isoquinoline alkaloid that can be isolated from a variety of herbs, on hydrogen peroxide (H2 O2 )-induced oxidative stress in C2C12 myoblasts and to investigate the molecular mechanisms involved in this process, especially the expression of the Nrf2/HO-1 pathway.	berberine chloride	81-104	nuclear factor, erythroid derived 2, like 2	Mus musculus	360-364
27535021-1	2016	Preclinical Research The aim of the present study was to evaluate the effects of berberine hydrochloride (BBH), an isoquinoline alkaloid that can be isolated from a variety of herbs, on hydrogen peroxide (H2 O2 )-induced oxidative stress in C2C12 myoblasts and to investigate the molecular mechanisms involved in this process, especially the expression of the Nrf2/HO-1 pathway.	berberine chloride	81-104	heme oxygenase 1	Mus musculus	365-369
27278862-0	2016	MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC 803 cell proliferation and IL-8 secretion in vitro and in vivo.	berberine chloride	55-78	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
25479718-11	2015	Furthermore, berberine hydrochloride inhibited the phosphorylation of the NF-kappaB p65 subunit and the degradation of its inhibitor, IkappaBalpha.	berberine chloride	13-36	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	134-146
24676878-9	2014	Our novel findings identified berberine hydrochloride as a promising strategy to prevent adhesion by downregulating ICAM-1 and reduce inflammation by inhibiting the TAK1/JNK and TAK1/NF-kappaB signaling after abdominal surgery, which brought out a good therapeutic approach for the development of clinical application for postoperative abdominal adhesion and inflammation.	berberine chloride	30-53	intercellular adhesion molecule 1	Rattus norvegicus	116-122
25335112-0	2014	Berberine hydrochloride IL-8 dependently inhibits invasion and IL-8-independently promotes cell apoptosis in MDA-MB-231 cells.	berberine chloride	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
25559449-6	2014	The IC50 values of celecoxib, rofecoxib, sinomenine, bulleyaconitine A, tetrandrine, fangchinoline, berberine hydrochloride and sophocarpidine towards COX-2 were determined.	berberine chloride	100-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
24767505-6	2014	It was observed from the adsorption experiments that the equilibrium adsorption amounts of berberine hydrochloride are strongly correlated with the BET specific surface area and pore volume of the adsorbents.	berberine chloride	91-114	delta/notch like EGF repeat containing	Homo sapiens	148-151
24767505-7	2014	The adsorbent with the highest BET of 2193.5 m(2)/g displayed the largest adsorption capacity of 574 mg/g at an equilibrium concentration of 0.10mg/mL of berberine hydrochloride in an aqueous solution.	berberine chloride	154-177	delta/notch like EGF repeat containing	Homo sapiens	31-34
24676878-9	2014	Our novel findings identified berberine hydrochloride as a promising strategy to prevent adhesion by downregulating ICAM-1 and reduce inflammation by inhibiting the TAK1/JNK and TAK1/NF-kappaB signaling after abdominal surgery, which brought out a good therapeutic approach for the development of clinical application for postoperative abdominal adhesion and inflammation.	berberine chloride	30-53	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	165-169
24676878-9	2014	Our novel findings identified berberine hydrochloride as a promising strategy to prevent adhesion by downregulating ICAM-1 and reduce inflammation by inhibiting the TAK1/JNK and TAK1/NF-kappaB signaling after abdominal surgery, which brought out a good therapeutic approach for the development of clinical application for postoperative abdominal adhesion and inflammation.	berberine chloride	30-53	mitogen-activated protein kinase 8	Rattus norvegicus	170-173
24676878-9	2014	Our novel findings identified berberine hydrochloride as a promising strategy to prevent adhesion by downregulating ICAM-1 and reduce inflammation by inhibiting the TAK1/JNK and TAK1/NF-kappaB signaling after abdominal surgery, which brought out a good therapeutic approach for the development of clinical application for postoperative abdominal adhesion and inflammation.	berberine chloride	30-53	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	178-182
21434883-3	2011	EXPERIMENTAL APPROACH: Through high-throughput cell-based screening using the NCI compound library, we identified NSC163088 (berberine chloride) as a novel inhibitor of JAK3.	berberine chloride	114-123	Janus kinase 3	Rattus norvegicus	169-173
23664937-0	2013	Effects of beta-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate.	berberine chloride	61-84	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	88-102
23664937-1	2013	The major objective of this work is to investigate the enhancing effect of beta-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein (Pgp) substrate.	berberine chloride	125-148	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	152-166
23664937-1	2013	The major objective of this work is to investigate the enhancing effect of beta-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein (Pgp) substrate.	berberine chloride	125-148	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	168-171
23948403-1	2013	OBJECTIVE: To investigate the effect of berberine hydrochloride (BBR) on the proliferation, apoptosis, TNF-alpha, IL-2 and IFN-gamma secretion of splenocytes in mice.	berberine chloride	40-63	interferon gamma	Mus musculus	123-132
23302384-0	2012	[Effect of berberine hydrochloride on the secretion of monocyte chemoattractant protein-1 from human periodontal ligament cells in vitro].	berberine chloride	11-34	C-C motif chemokine ligand 2	Homo sapiens	55-89
23302384-1	2012	OBJECTIVE: To observe the effects of berberine hydrochloride on the secretion of monocyte chemoattractant protein-1 (MCP-1) from human periodontal ligament cells (PDLC) in vitro culture.	berberine chloride	37-60	chemokine (C-C motif) ligand 2	Mus musculus	81-115
23302384-1	2012	OBJECTIVE: To observe the effects of berberine hydrochloride on the secretion of monocyte chemoattractant protein-1 (MCP-1) from human periodontal ligament cells (PDLC) in vitro culture.	berberine chloride	37-60	chemokine (C-C motif) ligand 2	Mus musculus	117-122
23302384-9	2012	CONCLUSIONS: The inhibitory effect of berberine hydrochloride on the activities of MCP-1 from PDLC was more significant when PDLC were stimulated with LPS and in a concentration-dependent manner.	berberine chloride	38-61	C-C motif chemokine ligand 2	Homo sapiens	83-88
21641970-0	2011	Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia.	berberine chloride	0-23	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	35-51
21641970-1	2011	The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia.	berberine chloride	14-37	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	57-73
21641970-1	2011	The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia.	berberine chloride	14-37	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	75-80
21434883-3	2011	EXPERIMENTAL APPROACH: Through high-throughput cell-based screening using the NCI compound library, we identified NSC163088 (berberine chloride) as a novel inhibitor of JAK3.	berberine chloride	125-143	Janus kinase 3	Rattus norvegicus	169-173
21434883-5	2011	KEY RESULTS: We show that berberine chloride has selectivity for JAK3 over other JAK kinase members, as well as over other oncogenic kinases such as Src, in various cellular assays.	berberine chloride	26-44	Janus kinase 3	Rattus norvegicus	65-69
21434883-5	2011	KEY RESULTS: We show that berberine chloride has selectivity for JAK3 over other JAK kinase members, as well as over other oncogenic kinases such as Src, in various cellular assays.	berberine chloride	26-44	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	149-152
21434883-6	2011	Biochemical and modelling studies strongly suggested that berberine chloride bound directly to the kinase domain of JAK3.	berberine chloride	58-76	Janus kinase 3	Rattus norvegicus	116-120
21434883-7	2011	Also phospho-JAK3 levels were significantly increased in the synovial tissues of rat joints with acute inflammation, and the treatment of these rats with berberine chloride decreased JAK3 phosphorylation and suppressed the inflammatory responses.	berberine chloride	154-172	Janus kinase 3	Rattus norvegicus	13-17
21434883-7	2011	Also phospho-JAK3 levels were significantly increased in the synovial tissues of rat joints with acute inflammation, and the treatment of these rats with berberine chloride decreased JAK3 phosphorylation and suppressed the inflammatory responses.	berberine chloride	154-172	Janus kinase 3	Rattus norvegicus	183-187
21434883-8	2011	CONCLUSIONS AND IMPLICATIONS: The up-regulation of JAK3/STATs was closely correlated with acute arthritic inflammation and that inhibition of JAK3 activity by JAK3 antagonists, such as berberine chloride, alleviated the inflammation in vivo.	berberine chloride	185-203	Janus kinase 3	Rattus norvegicus	51-55
21434883-8	2011	CONCLUSIONS AND IMPLICATIONS: The up-regulation of JAK3/STATs was closely correlated with acute arthritic inflammation and that inhibition of JAK3 activity by JAK3 antagonists, such as berberine chloride, alleviated the inflammation in vivo.	berberine chloride	185-203	Janus kinase 3	Rattus norvegicus	142-146
21434883-8	2011	CONCLUSIONS AND IMPLICATIONS: The up-regulation of JAK3/STATs was closely correlated with acute arthritic inflammation and that inhibition of JAK3 activity by JAK3 antagonists, such as berberine chloride, alleviated the inflammation in vivo.	berberine chloride	185-203	Janus kinase 3	Rattus norvegicus	142-146
21647250-10	2011	Berberine hydrochloride at 25 microM attenuated insulin-suppressed Pck1 (ZL/ZF cells), and insulin-induced Srebp-1c expression (SD/ZL/ZF cells), suggesting modulation of insulin action.	berberine chloride	0-23	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	67-71
21524698-6	2011	Moreover, ligustilide, schisantherin A, berberine hydrochloride and trans-resveratrol were identified for the first time as efficacious PXR agonists.	berberine chloride	40-63	nuclear receptor subfamily 1 group I member 2	Homo sapiens	136-139
21483684-6	2011	Measurement of the mRNA expression of iNOS, IL-12 and IL-10 by RT-PCR along with levels of IL-12p40 and IL-10 by ELISA showed that in infected macrophages, Berberine chloride enhanced expression of iNOS and IL-12p40, concomitant with a downregulation of IL-10.	berberine chloride	156-174	inositol-3-phosphate synthase 1	Homo sapiens	38-42
21483684-6	2011	Measurement of the mRNA expression of iNOS, IL-12 and IL-10 by RT-PCR along with levels of IL-12p40 and IL-10 by ELISA showed that in infected macrophages, Berberine chloride enhanced expression of iNOS and IL-12p40, concomitant with a downregulation of IL-10.	berberine chloride	156-174	interleukin 10	Homo sapiens	54-59
21483684-6	2011	Measurement of the mRNA expression of iNOS, IL-12 and IL-10 by RT-PCR along with levels of IL-12p40 and IL-10 by ELISA showed that in infected macrophages, Berberine chloride enhanced expression of iNOS and IL-12p40, concomitant with a downregulation of IL-10.	berberine chloride	156-174	interleukin 10	Homo sapiens	104-109
21483684-6	2011	Measurement of the mRNA expression of iNOS, IL-12 and IL-10 by RT-PCR along with levels of IL-12p40 and IL-10 by ELISA showed that in infected macrophages, Berberine chloride enhanced expression of iNOS and IL-12p40, concomitant with a downregulation of IL-10.	berberine chloride	156-174	inositol-3-phosphate synthase 1	Homo sapiens	198-202
21483684-6	2011	Measurement of the mRNA expression of iNOS, IL-12 and IL-10 by RT-PCR along with levels of IL-12p40 and IL-10 by ELISA showed that in infected macrophages, Berberine chloride enhanced expression of iNOS and IL-12p40, concomitant with a downregulation of IL-10.	berberine chloride	156-174	interleukin 10	Homo sapiens	104-109
21483684-8	2011	In infected macrophages, Berberine chloride caused a time dependent activation of p38 MAPK along with deactivation of ERK1/2; addition of a p38 MAPK inhibitor SB203580 inhibited the increased generation of NO and IL-12p40 by Berberine chloride as also prevented its decrease of IL-10.	berberine chloride	25-43	mitogen-activated protein kinase 14	Homo sapiens	82-90
21483684-8	2011	In infected macrophages, Berberine chloride caused a time dependent activation of p38 MAPK along with deactivation of ERK1/2; addition of a p38 MAPK inhibitor SB203580 inhibited the increased generation of NO and IL-12p40 by Berberine chloride as also prevented its decrease of IL-10.	berberine chloride	25-43	mitogen-activated protein kinase 3	Homo sapiens	118-124
21483684-8	2011	In infected macrophages, Berberine chloride caused a time dependent activation of p38 MAPK along with deactivation of ERK1/2; addition of a p38 MAPK inhibitor SB203580 inhibited the increased generation of NO and IL-12p40 by Berberine chloride as also prevented its decrease of IL-10.	berberine chloride	25-43	mitogen-activated protein kinase 14	Homo sapiens	140-148
21483684-8	2011	In infected macrophages, Berberine chloride caused a time dependent activation of p38 MAPK along with deactivation of ERK1/2; addition of a p38 MAPK inhibitor SB203580 inhibited the increased generation of NO and IL-12p40 by Berberine chloride as also prevented its decrease of IL-10.	berberine chloride	25-43	interleukin 10	Homo sapiens	278-283
21483684-8	2011	In infected macrophages, Berberine chloride caused a time dependent activation of p38 MAPK along with deactivation of ERK1/2; addition of a p38 MAPK inhibitor SB203580 inhibited the increased generation of NO and IL-12p40 by Berberine chloride as also prevented its decrease of IL-10.	berberine chloride	225-243	mitogen-activated protein kinase 14	Homo sapiens	82-90
21483684-8	2011	In infected macrophages, Berberine chloride caused a time dependent activation of p38 MAPK along with deactivation of ERK1/2; addition of a p38 MAPK inhibitor SB203580 inhibited the increased generation of NO and IL-12p40 by Berberine chloride as also prevented its decrease of IL-10.	berberine chloride	225-243	mitogen-activated protein kinase 14	Homo sapiens	140-148
21483684-9	2011	CONCLUSIONS: Berberine chloride modulated macrophage effector responses via the mitogen activated protein kinase (MAPK) pathway, highlighting the importance of MAPKs as an antiparasite target.	berberine chloride	13-31	mitogen-activated protein kinase 3	Homo sapiens	114-118
19902381-7	2010	Furthermore, an HP-induced decrease in cell injury was reversed by berberine chloride (BB), the inhibitor of AR.	berberine chloride	67-85	aldo-keto reductase family 1 member B1	Rattus norvegicus	109-111
18357892-0	2008	[Effect of berberine hydrochloride on the expression of interleukin-1beta and tumor necrosis factor-alpha in periodontal tissues in rats].	berberine chloride	11-34	interleukin 1 beta	Rattus norvegicus	56-73
18357892-0	2008	[Effect of berberine hydrochloride on the expression of interleukin-1beta and tumor necrosis factor-alpha in periodontal tissues in rats].	berberine chloride	11-34	tumor necrosis factor	Rattus norvegicus	78-105
18357892-1	2008	OBJECTIVE: To determine the effects of berberine hydrochloride on the expressions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in periodontal tissues in rat periodontitis model.	berberine chloride	39-62	interleukin 1 beta	Rattus norvegicus	85-102
18357892-1	2008	OBJECTIVE: To determine the effects of berberine hydrochloride on the expressions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in periodontal tissues in rat periodontitis model.	berberine chloride	39-62	interleukin 1 beta	Rattus norvegicus	104-112
18357892-1	2008	OBJECTIVE: To determine the effects of berberine hydrochloride on the expressions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in periodontal tissues in rat periodontitis model.	berberine chloride	39-62	tumor necrosis factor	Rattus norvegicus	118-145
18357892-1	2008	OBJECTIVE: To determine the effects of berberine hydrochloride on the expressions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in periodontal tissues in rat periodontitis model.	berberine chloride	39-62	tumor necrosis factor	Rattus norvegicus	147-156
18357892-6	2008	Treatment with berberine hydrochloride decreased the levels of IL-1beta and TNF-alpha in periodontitis tissues (P<0.05).	berberine chloride	15-38	interleukin 1 beta	Rattus norvegicus	63-71
18357892-6	2008	Treatment with berberine hydrochloride decreased the levels of IL-1beta and TNF-alpha in periodontitis tissues (P<0.05).	berberine chloride	15-38	tumor necrosis factor	Rattus norvegicus	76-85
18357892-8	2008	CONCLUSION: Berberine hydrochloride inhibited the expression of IL-1beta and TNF-alpha in periodontal tissues in rats periodontitis model and promoted the regeneration of the periodontal tissues.	berberine chloride	12-35	interleukin 1 beta	Rattus norvegicus	64-72
18357892-8	2008	CONCLUSION: Berberine hydrochloride inhibited the expression of IL-1beta and TNF-alpha in periodontal tissues in rats periodontitis model and promoted the regeneration of the periodontal tissues.	berberine chloride	12-35	tumor necrosis factor	Rattus norvegicus	77-86
9206261-0	1996	[Interaction of human serum albumin with berberine hydrochloride by fluorescence method].	berberine chloride	41-64	albumin	Homo sapiens	22-35
12069410-0	2002	Monitoring and kinetic parameter estimation for the binding process of berberine hydrochloride to bovine serum albumin with piezoelectric quartz crystal impedance analysis.	berberine chloride	71-94	albumin	Homo sapiens	105-118
12069410-2	2002	The method was used to monitor the binding process of berberine hydrochloride to bovine serum albumin (BSA).	berberine chloride	54-77	albumin	Homo sapiens	88-101
17679427-0	2007	[Investigation on binding interaction of berberine chloride with bovine serum albumin immobilized onto chromatographic supports by frontal chromatography].	berberine chloride	41-59	albumin	Homo sapiens	72-85
17137520-0	2006	Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer"s disease.	berberine chloride	0-18	interleukin 1 beta	Rattus norvegicus	95-112
17137520-0	2006	Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer"s disease.	berberine chloride	0-18	nitric oxide synthase 2	Rattus norvegicus	117-148
17137520-3	2006	The present study was carried out to investigate the effect of berberine chloride on the spatial memory, inflammation factors interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) expression in the rat model of Alzheimer"s disease (AD) which was established by injecting Abeta (1-40) (5 microgram) into the rats hippocampuses bilaterally.	berberine chloride	63-81	interleukin 1 beta	Rattus norvegicus	126-144
9206261-1	1996	Fluorescence method has been used to observe the fluorescence quenching of human serum albumin (HSA) by its interaction with berberine hydrochloride (BH).	berberine chloride	125-148	albumin	Homo sapiens	81-94
34467733-11	2021	Berberine hydrochloride was verified to be capable of diminishing phosphorylated PI3 K/Akt protein expression.	berberine chloride	0-23	AKT serine/threonine kinase 1	Homo sapiens	87-90
1696505-1	1990	The interaction of berberine chloride with poly(A) and tRNA has been studied by various spectroscopic techniques.	berberine chloride	19-37	mitochondrially encoded tRNA glycine	Homo sapiens	55-59
34467733-12	2021	The findings indicate that aesculin, anemoside B4, and especially berberine hydrochloride in the BAEB can inhibit the chemotaxis of neutrophils, which is possibly achieved by the inhibition of F-actin and PI3 K/Akt signaling pathway.	berberine chloride	66-89	AKT serine/threonine kinase 1	Homo sapiens	211-214
35385268-8	2022	Moreover, five alkaloids, namely, berberine hydrochloride, caffeine, camptothecin, matrine, and evodiamine, were screened by using neostigmine bromide as a control; berberine hydrochloride exhibited a good inhibitory effect on AChE with an IC50 of 0.94 muM, while the other four had no obvious inhibitory effect.	berberine chloride	34-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	227-231
35612892-0	2022	Berberine chloride (dual topoisomerase I and II inhibitor) modulate mitochondrial uncoupling protein (UCP1) in molecular docking and dynamic with in-vitro cytotoxic and mitochondrial ATP production.	berberine chloride	0-18	uncoupling protein 1	Homo sapiens	102-106
35612892-8	2022	In this study, berberine chloride significantly up-regulates UCP1 gene expression in brown adipocytes.	berberine chloride	15-33	uncoupling protein 1	Homo sapiens	61-65
35385268-8	2022	Moreover, five alkaloids, namely, berberine hydrochloride, caffeine, camptothecin, matrine, and evodiamine, were screened by using neostigmine bromide as a control; berberine hydrochloride exhibited a good inhibitory effect on AChE with an IC50 of 0.94 muM, while the other four had no obvious inhibitory effect.	berberine chloride	165-188	acetylcholinesterase (Cartwright blood group)	Homo sapiens	227-231
747733-3	1978	Berberine chloride can be determined in a concentration of 10 ng ml-1 in human urine by the method described.	berberine chloride	0-18	interleukin 17F	Homo sapiens	65-69
35078575-0	2022	(Berberine hydrochloride attenuates liver injury induced by acute hypoxic exposure by inhibiting TNF-alpha/caspase-8/caspase-3 signaling pathway).	berberine chloride	1-24	tumor necrosis factor	Mus musculus	97-106
35078575-0	2022	(Berberine hydrochloride attenuates liver injury induced by acute hypoxic exposure by inhibiting TNF-alpha/caspase-8/caspase-3 signaling pathway).	berberine chloride	1-24	caspase 8	Mus musculus	107-116
35078575-0	2022	(Berberine hydrochloride attenuates liver injury induced by acute hypoxic exposure by inhibiting TNF-alpha/caspase-8/caspase-3 signaling pathway).	berberine chloride	1-24	caspase 3	Mus musculus	117-126
33652886-0	2021	Co-Delivery of Berberine Chloride and Tariquidar in Nanoliposomes Enhanced Intracellular Berberine Chloride in a Doxorubicin-Resistant K562 Cell Line Due to P-gp Overexpression.	berberine chloride	15-33	phosphoglycolate phosphatase	Homo sapiens	157-161
33179429-1	2021	In this report, we develop a dual-output sensor with fluorometric and colorimetric responses, for the rapid and simple detection of Berberine hydrochloride (BRH) in 100% aqueous solution based on an anionic polythiophene derivative, poly (2-(2-(4-methylthiophen-3-yloxy)-ethyl) malonic acid) (PTMA).	berberine chloride	132-155	prothymosin alpha	Homo sapiens	293-297
33656348-0	2021	Novel Salt-Cocrystals of Berberine Hydrochloride with Aliphatic Dicarboxylic Acids: Odd-Even Alternation in Physicochemical Properties.	berberine chloride	25-48	odd-skipped related transcription factor 1	Homo sapiens	84-87
33652886-2	2021	In the present paper, the co-delivery of berberine chloride and tariquidar loaded nanoliposomes was investigated with the aim of enhancing solubility and improving desired effects for the antineoplastic drug and the P-gp inhibitor.	berberine chloride	41-59	phosphoglycolate phosphatase	Homo sapiens	216-220
32828421-8	2020	From this screen, we identified berberine chloride and zinc chloride as the first noncompetitive inhibitors of SARM1.	berberine chloride	32-50	sterile alpha and TIR motif containing 1	Homo sapiens	111-116
31512260-0	2019	Berberine chloride ameliorated PI3K/Akt-p/SIRT-1/PTEN signaling pathway in insulin resistance syndrome induced in rats.	berberine chloride	0-18	sirtuin 1	Rattus norvegicus	42-48
32607786-0	2020	Berberine chloride suppresses non-small cell lung cancer by deregulating Sin3A/TOP2B pathway in vitro and in vivo.	berberine chloride	0-18	sin3a	None	73-78
32607786-0	2020	Berberine chloride suppresses non-small cell lung cancer by deregulating Sin3A/TOP2B pathway in vitro and in vivo.	berberine chloride	0-18	top2b	None	79-84
31512260-0	2019	Berberine chloride ameliorated PI3K/Akt-p/SIRT-1/PTEN signaling pathway in insulin resistance syndrome induced in rats.	berberine chloride	0-18	phosphatase and tensin homolog	Rattus norvegicus	49-53
30743078-10	2019	The expression of IL-1, IL-1beta, IL-6, IL-12, TNF-alpha, TGF-beta and IFN-gamma were suppressed, yet the expression of IL-4 and IL-10 were up-regulated by berberine hydrochloride and sulphasalazine treatment compared to the model group.	berberine chloride	156-179	interleukin 4	Rattus norvegicus	120-124
30743078-10	2019	The expression of IL-1, IL-1beta, IL-6, IL-12, TNF-alpha, TGF-beta and IFN-gamma were suppressed, yet the expression of IL-4 and IL-10 were up-regulated by berberine hydrochloride and sulphasalazine treatment compared to the model group.	berberine chloride	156-179	interleukin 10	Rattus norvegicus	129-134
30743078-11	2019	Meanwhile, treatment with berberine hydrochloride effectively increased the expression of SIgA and decreased the expression of iNOS, MPO, MDA.	berberine chloride	26-49	nitric oxide synthase 2	Rattus norvegicus	127-131
30743078-11	2019	Meanwhile, treatment with berberine hydrochloride effectively increased the expression of SIgA and decreased the expression of iNOS, MPO, MDA.	berberine chloride	26-49	myeloperoxidase	Rattus norvegicus	133-136
30743078-14	2019	The possible mechanism of anti-inflammatory response by berberine hydrochloride may involve in the blocking of the IL-6/STAT3/NF-kappaB signaling pathway.	berberine chloride	56-79	interleukin 6	Rattus norvegicus	115-119
30743078-14	2019	The possible mechanism of anti-inflammatory response by berberine hydrochloride may involve in the blocking of the IL-6/STAT3/NF-kappaB signaling pathway.	berberine chloride	56-79	signal transducer and activator of transcription 3	Rattus norvegicus	120-125
30121557-2	2018	In this synthesis process of T-MIR, 2-acrylamide-2- methylpropanesulfonic acid (AMPS) and acrylamide (AAm) were coupled as zipper-like thermo-responsive monomers, resorcinol, and melamine as hydrophilic monomers, formaldehyde as a cross-linker, and berberine chloride (BerbC) as the template.	berberine chloride	249-267	membrane associated ring-CH-type finger 8	Homo sapiens	31-34
30891078-4	2019	Pretreatment with puerarin, baicalin, and berberine hydrochloride improved the structure and morphology of IPEC-J2 cells and inhibited ETEC adhesion by downregulating specific adhesion molecules.	berberine chloride	42-65	ETEC	Sus scrofa	135-139
30891078-6	2019	Pretreatment with puerarin, baicalin, and berberine hydrochloride protected IPEC-J2 cells from ETEC infection by inhibiting bacterial adhesion and inflammatory responses.	berberine chloride	42-65	ETEC	Sus scrofa	95-99
30834080-0	2019	Effect of berberine chloride on caspase-3 dependent apoptosis and antioxidant capacity in the hippocampus of the chronic cerebral hypoperfusion rat model.	berberine chloride	10-28	caspase 3	Rattus norvegicus	32-41
28679068-0	2018	Berberine hydrochloride counteracts enhanced IL-8 expression induced by SN 38 in AGS cells.	berberine chloride	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
28679068-2	2018	In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4.	berberine chloride	18-41	cyclin B1	Homo sapiens	150-159
28679068-2	2018	In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4.	berberine chloride	18-41	BCL2 apoptosis regulator	Homo sapiens	161-166
28679068-2	2018	In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4.	berberine chloride	18-41	H3 histone pseudogene 16	Homo sapiens	195-198
28679068-2	2018	In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4.	berberine chloride	18-41	tumor protein p53	Homo sapiens	200-203
28679068-2	2018	In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4.	berberine chloride	18-41	caspase 3	Homo sapiens	216-225
28679068-2	2018	In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4.	berberine chloride	18-41	DNA damage inducible transcript 3	Homo sapiens	273-277
28679068-2	2018	In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4.	berberine chloride	18-41	growth differentiation factor 10	Homo sapiens	279-282
28679068-2	2018	In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4.	berberine chloride	18-41	caspase 4	Homo sapiens	288-297
29849710-10	2018	Results indicated that berberine hydrochloride significantly attenuated neutrophil infiltration and dose-dependently decreased the secretion and mRNA expressions of TNF-alpha, IL-1beta, and IL-6 within a certain range.	berberine chloride	23-46	tumor necrosis factor	Mus musculus	165-174
30166108-9	2018	Furthermore, berberine hydrochloride, a primary constituent of DGLHT-E inhibited the expressions of the proliferation markers K16 and K17 in IL-22 stimulated HaCaT cells.	berberine chloride	13-36	keratin 17	Homo sapiens	134-137
30166108-9	2018	Furthermore, berberine hydrochloride, a primary constituent of DGLHT-E inhibited the expressions of the proliferation markers K16 and K17 in IL-22 stimulated HaCaT cells.	berberine chloride	13-36	interleukin 22	Homo sapiens	141-146
29441466-1	2018	To promote the specific targeting and elimination of CD44-positive cancer cells, berberine chloride (BRB)-encapsulated hyaluronic acid-grafted poly(lactic-co-glycolic acid) copolymer (BRB-d(HA)-g-PLGA) nanoparticles (NPs) were prepared.	berberine chloride	81-99	CD44 molecule (Indian blood group)	Homo sapiens	53-57
29725453-0	2018	Berberine hydrochloride inhibits cell proliferation and promotes apoptosis of non-small cell lung cancer via the suppression of the MMP2 and Bcl-2/Bax signaling pathways.	berberine chloride	0-23	matrix metallopeptidase 2	Homo sapiens	132-136
29725453-0	2018	Berberine hydrochloride inhibits cell proliferation and promotes apoptosis of non-small cell lung cancer via the suppression of the MMP2 and Bcl-2/Bax signaling pathways.	berberine chloride	0-23	BCL2 apoptosis regulator	Homo sapiens	141-146
29725453-0	2018	Berberine hydrochloride inhibits cell proliferation and promotes apoptosis of non-small cell lung cancer via the suppression of the MMP2 and Bcl-2/Bax signaling pathways.	berberine chloride	0-23	BCL2 associated X, apoptosis regulator	Homo sapiens	147-150
29725453-3	2018	The present study aimed to determine the possible anticancer effects of berberine hydrochloride treatment on human non-small cell lung cancer (NSCLC) cell proliferation and apoptosis via the matrix metalloproteinase 2 (MMP-2) and the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax) signaling pathway.	berberine chloride	72-95	matrix metallopeptidase 2	Homo sapiens	191-217
29725453-3	2018	The present study aimed to determine the possible anticancer effects of berberine hydrochloride treatment on human non-small cell lung cancer (NSCLC) cell proliferation and apoptosis via the matrix metalloproteinase 2 (MMP-2) and the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax) signaling pathway.	berberine chloride	72-95	matrix metallopeptidase 2	Homo sapiens	219-224
29725453-3	2018	The present study aimed to determine the possible anticancer effects of berberine hydrochloride treatment on human non-small cell lung cancer (NSCLC) cell proliferation and apoptosis via the matrix metalloproteinase 2 (MMP-2) and the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax) signaling pathway.	berberine chloride	72-95	BCL2 apoptosis regulator	Homo sapiens	234-251
29725453-3	2018	The present study aimed to determine the possible anticancer effects of berberine hydrochloride treatment on human non-small cell lung cancer (NSCLC) cell proliferation and apoptosis via the matrix metalloproteinase 2 (MMP-2) and the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax) signaling pathway.	berberine chloride	72-95	BCL2 apoptosis regulator	Homo sapiens	253-258
29725453-3	2018	The present study aimed to determine the possible anticancer effects of berberine hydrochloride treatment on human non-small cell lung cancer (NSCLC) cell proliferation and apoptosis via the matrix metalloproteinase 2 (MMP-2) and the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax) signaling pathway.	berberine chloride	72-95	BCL2 associated X, apoptosis regulator	Homo sapiens	260-286
29725453-3	2018	The present study aimed to determine the possible anticancer effects of berberine hydrochloride treatment on human non-small cell lung cancer (NSCLC) cell proliferation and apoptosis via the matrix metalloproteinase 2 (MMP-2) and the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax) signaling pathway.	berberine chloride	72-95	BCL2 associated X, apoptosis regulator	Homo sapiens	288-291
29725453-6	2018	Berberine hydrochloride treatment inhibited the expression of vascular endothelial growth factor (VEGF) and nuclear factor kappaB (NF-kappaB) and transcription factor AP-1 (AP-1) proteins, in A549 cells.	berberine chloride	0-23	vascular endothelial growth factor A	Homo sapiens	62-96
29725453-6	2018	Berberine hydrochloride treatment inhibited the expression of vascular endothelial growth factor (VEGF) and nuclear factor kappaB (NF-kappaB) and transcription factor AP-1 (AP-1) proteins, in A549 cells.	berberine chloride	0-23	vascular endothelial growth factor A	Homo sapiens	98-102
29725453-6	2018	Berberine hydrochloride treatment inhibited the expression of vascular endothelial growth factor (VEGF) and nuclear factor kappaB (NF-kappaB) and transcription factor AP-1 (AP-1) proteins, in A549 cells.	berberine chloride	0-23	nuclear factor kappa B subunit 1	Homo sapiens	123-129
29725453-6	2018	Berberine hydrochloride treatment inhibited the expression of vascular endothelial growth factor (VEGF) and nuclear factor kappaB (NF-kappaB) and transcription factor AP-1 (AP-1) proteins, in A549 cells.	berberine chloride	0-23	nuclear factor kappa B subunit 1	Homo sapiens	131-140
29725453-6	2018	Berberine hydrochloride treatment inhibited the expression of vascular endothelial growth factor (VEGF) and nuclear factor kappaB (NF-kappaB) and transcription factor AP-1 (AP-1) proteins, in A549 cells.	berberine chloride	0-23	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-171
29725453-6	2018	Berberine hydrochloride treatment inhibited the expression of vascular endothelial growth factor (VEGF) and nuclear factor kappaB (NF-kappaB) and transcription factor AP-1 (AP-1) proteins, in A549 cells.	berberine chloride	0-23	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	173-177
29725453-8	2018	Subsequently, treatment with berberine hydrochloride significantly downregulated MMP-2 protein expression, increased the activity of the Bcl-2/Bax signaling pathway and suppressed the Jak2/VEGF/NF-kappaB/AP-1signaling pathways.	berberine chloride	29-52	matrix metallopeptidase 2	Homo sapiens	81-86
29725453-8	2018	Subsequently, treatment with berberine hydrochloride significantly downregulated MMP-2 protein expression, increased the activity of the Bcl-2/Bax signaling pathway and suppressed the Jak2/VEGF/NF-kappaB/AP-1signaling pathways.	berberine chloride	29-52	BCL2 apoptosis regulator	Homo sapiens	137-142
29725453-8	2018	Subsequently, treatment with berberine hydrochloride significantly downregulated MMP-2 protein expression, increased the activity of the Bcl-2/Bax signaling pathway and suppressed the Jak2/VEGF/NF-kappaB/AP-1signaling pathways.	berberine chloride	29-52	BCL2 associated X, apoptosis regulator	Homo sapiens	143-146
29725453-8	2018	Subsequently, treatment with berberine hydrochloride significantly downregulated MMP-2 protein expression, increased the activity of the Bcl-2/Bax signaling pathway and suppressed the Jak2/VEGF/NF-kappaB/AP-1signaling pathways.	berberine chloride	29-52	Janus kinase 2	Homo sapiens	184-188
29725453-8	2018	Subsequently, treatment with berberine hydrochloride significantly downregulated MMP-2 protein expression, increased the activity of the Bcl-2/Bax signaling pathway and suppressed the Jak2/VEGF/NF-kappaB/AP-1signaling pathways.	berberine chloride	29-52	vascular endothelial growth factor A	Homo sapiens	189-193
29725453-8	2018	Subsequently, treatment with berberine hydrochloride significantly downregulated MMP-2 protein expression, increased the activity of the Bcl-2/Bax signaling pathway and suppressed the Jak2/VEGF/NF-kappaB/AP-1signaling pathways.	berberine chloride	29-52	nuclear factor kappa B subunit 1	Homo sapiens	194-203
29725453-8	2018	Subsequently, treatment with berberine hydrochloride significantly downregulated MMP-2 protein expression, increased the activity of the Bcl-2/Bax signaling pathway and suppressed the Jak2/VEGF/NF-kappaB/AP-1signaling pathways.	berberine chloride	29-52	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	204-208
29725453-9	2018	These results suggest that berberine hydrochloride may be a potential novel anticancer drug, since it inhibits cell proliferation and promotes the rate of apoptosis of NSCLC cells by the suppression of the MMP-2, Bcl-2/Bax and Jak2/VEGF/NF-kappaB/AP-1 signaling pathways.	berberine chloride	27-50	matrix metallopeptidase 2	Homo sapiens	206-211
29725453-9	2018	These results suggest that berberine hydrochloride may be a potential novel anticancer drug, since it inhibits cell proliferation and promotes the rate of apoptosis of NSCLC cells by the suppression of the MMP-2, Bcl-2/Bax and Jak2/VEGF/NF-kappaB/AP-1 signaling pathways.	berberine chloride	27-50	BCL2 apoptosis regulator	Homo sapiens	213-218
29725453-9	2018	These results suggest that berberine hydrochloride may be a potential novel anticancer drug, since it inhibits cell proliferation and promotes the rate of apoptosis of NSCLC cells by the suppression of the MMP-2, Bcl-2/Bax and Jak2/VEGF/NF-kappaB/AP-1 signaling pathways.	berberine chloride	27-50	BCL2 associated X, apoptosis regulator	Homo sapiens	219-222
29725453-9	2018	These results suggest that berberine hydrochloride may be a potential novel anticancer drug, since it inhibits cell proliferation and promotes the rate of apoptosis of NSCLC cells by the suppression of the MMP-2, Bcl-2/Bax and Jak2/VEGF/NF-kappaB/AP-1 signaling pathways.	berberine chloride	27-50	Janus kinase 2	Homo sapiens	227-231
29725453-9	2018	These results suggest that berberine hydrochloride may be a potential novel anticancer drug, since it inhibits cell proliferation and promotes the rate of apoptosis of NSCLC cells by the suppression of the MMP-2, Bcl-2/Bax and Jak2/VEGF/NF-kappaB/AP-1 signaling pathways.	berberine chloride	27-50	vascular endothelial growth factor A	Homo sapiens	232-236
29725453-9	2018	These results suggest that berberine hydrochloride may be a potential novel anticancer drug, since it inhibits cell proliferation and promotes the rate of apoptosis of NSCLC cells by the suppression of the MMP-2, Bcl-2/Bax and Jak2/VEGF/NF-kappaB/AP-1 signaling pathways.	berberine chloride	27-50	nuclear factor kappa B subunit 1	Homo sapiens	237-246
29725453-9	2018	These results suggest that berberine hydrochloride may be a potential novel anticancer drug, since it inhibits cell proliferation and promotes the rate of apoptosis of NSCLC cells by the suppression of the MMP-2, Bcl-2/Bax and Jak2/VEGF/NF-kappaB/AP-1 signaling pathways.	berberine chloride	27-50	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	247-251
29849710-11	2018	Furthermore, berberine hydrochloride suppressed LPS-induced TLR4 and NF-kappaB p65 activation and the phosphorylation of I-kappaB.	berberine chloride	13-36	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	79-82
29849710-12	2018	Berberine hydrochloride can provide mice robust protection from LPS-induced mastitis, potentially via the TLR4 and NF-kappaB pathway.	berberine chloride	0-23	toll-like receptor 4	Mus musculus	106-110
29849710-12	2018	Berberine hydrochloride can provide mice robust protection from LPS-induced mastitis, potentially via the TLR4 and NF-kappaB pathway.	berberine chloride	0-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
29849710-10	2018	Results indicated that berberine hydrochloride significantly attenuated neutrophil infiltration and dose-dependently decreased the secretion and mRNA expressions of TNF-alpha, IL-1beta, and IL-6 within a certain range.	berberine chloride	23-46	interleukin 1 beta	Mus musculus	176-184
29849710-10	2018	Results indicated that berberine hydrochloride significantly attenuated neutrophil infiltration and dose-dependently decreased the secretion and mRNA expressions of TNF-alpha, IL-1beta, and IL-6 within a certain range.	berberine chloride	23-46	interleukin 6	Mus musculus	190-194
29849710-11	2018	Furthermore, berberine hydrochloride suppressed LPS-induced TLR4 and NF-kappaB p65 activation and the phosphorylation of I-kappaB.	berberine chloride	13-36	toll-like receptor 4	Mus musculus	60-64
29849710-11	2018	Furthermore, berberine hydrochloride suppressed LPS-induced TLR4 and NF-kappaB p65 activation and the phosphorylation of I-kappaB.	berberine chloride	13-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
29422010-6	2018	Pearson"s correlation analysis of PCSK-9 mRNA and protein levels in Berberine chloride delivery was performed.	berberine chloride	68-86	proprotein convertase subtilisin/kexin type 9	Homo sapiens	34-40
29372037-10	2018	Conclusion: Berberine chloride may be considered as a potential treatment for cognitive deficits and neuronal injury caused by CCH in the hippocampal CA1 area.	berberine chloride	12-30	carbonic anhydrase 1	Rattus norvegicus	150-153
28849049-0	2017	The protective effect of berberine hydrochloride on LPS-induced osteoclastogenesis through inhibiting TRAF6-Ca2+-calcineurin-NFATcl signaling pathway.	berberine chloride	25-48	TNF receptor-associated factor 6	Mus musculus	102-107
28578289-1	2017	The present study reports a meticulous characterization of the interaction of a potent anti-cancer drug, berberine chloride (BR) with a series of bile salt aggregates having varying hydrophobicity (sodium deoxycholate (NaDC), sodium cholate (NaC), and sodium taurocholate (NaTC)).	berberine chloride	105-123	synuclein alpha	Homo sapiens	242-245
28849049-7	2017	The PCR results demonstrated that berberine hydrochloride inhibited the mRNA expression levels of Fra-2, TRAP, beta3-integrin, cathepsin K, DC-STAMP, Atp6v0d2 and NFATc1.	berberine chloride	34-57	dendrocyte expressed seven transmembrane protein	Mus musculus	140-148
28849049-7	2017	The PCR results demonstrated that berberine hydrochloride inhibited the mRNA expression levels of Fra-2, TRAP, beta3-integrin, cathepsin K, DC-STAMP, Atp6v0d2 and NFATc1.	berberine chloride	34-57	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	150-158
28849049-1	2017	The present study investigated the protective effect of berberine hydrochloride on lipopolysaccharide (LPS) -induced acute bone destruction through inhibition of the TNF receptor associated factor 6 (TRAF6)-Ca2+-calcineurin-nuclear factor of activated T-cell 1 (NFATc1) signaling pathway.	berberine chloride	56-79	TNF receptor-associated factor 6	Mus musculus	166-198
28849049-7	2017	The PCR results demonstrated that berberine hydrochloride inhibited the mRNA expression levels of Fra-2, TRAP, beta3-integrin, cathepsin K, DC-STAMP, Atp6v0d2 and NFATc1.	berberine chloride	34-57	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	163-169
28849049-1	2017	The present study investigated the protective effect of berberine hydrochloride on lipopolysaccharide (LPS) -induced acute bone destruction through inhibition of the TNF receptor associated factor 6 (TRAF6)-Ca2+-calcineurin-nuclear factor of activated T-cell 1 (NFATc1) signaling pathway.	berberine chloride	56-79	TNF receptor-associated factor 6	Mus musculus	200-205
28849049-9	2017	The western blot analysis revelead that berberine hydrochloride treatment results in decreased expression levels of PLC-gamma1, TLR4 and TRAF6, and inhibition of Ca2+ influx.	berberine chloride	40-63	phospholipase C, gamma 1	Mus musculus	116-126
28849049-9	2017	The western blot analysis revelead that berberine hydrochloride treatment results in decreased expression levels of PLC-gamma1, TLR4 and TRAF6, and inhibition of Ca2+ influx.	berberine chloride	40-63	toll-like receptor 4	Mus musculus	128-132
28849049-9	2017	The western blot analysis revelead that berberine hydrochloride treatment results in decreased expression levels of PLC-gamma1, TLR4 and TRAF6, and inhibition of Ca2+ influx.	berberine chloride	40-63	TNF receptor-associated factor 6	Mus musculus	137-142
28849049-10	2017	In conclusion, the results of the present study suggest that berberine hydrochloride targets TRAF6 and NFATc1, thus inhibiting osteoclastogenesis and bone destruction via inhibition of the TRAF6-Ca2+-calcineurin-NFATcl signaling pathway.	berberine chloride	61-84	TNF receptor-associated factor 6	Mus musculus	93-98
28849049-10	2017	In conclusion, the results of the present study suggest that berberine hydrochloride targets TRAF6 and NFATc1, thus inhibiting osteoclastogenesis and bone destruction via inhibition of the TRAF6-Ca2+-calcineurin-NFATcl signaling pathway.	berberine chloride	61-84	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	103-109
28849049-10	2017	In conclusion, the results of the present study suggest that berberine hydrochloride targets TRAF6 and NFATc1, thus inhibiting osteoclastogenesis and bone destruction via inhibition of the TRAF6-Ca2+-calcineurin-NFATcl signaling pathway.	berberine chloride	61-84	TNF receptor-associated factor 6	Mus musculus	189-194
28849049-3	2017	A polymerase chain reaction (PCR) assay was applied to determine the effect of berberine hydrochloride on the mRNA expression levels of fos-related antigen 2 (Fra-2), tartrate-resistant acid phosphatase (TRAP), beta3-integrin, cathepsin K, dendritic cell-specific transmembrane protein (DC-STAMP), V-type proton ATPase subunit d 2 (Atp6v0d2) and NFATcl.	berberine chloride	79-102	fos-like antigen 2	Mus musculus	136-157
28849049-3	2017	A polymerase chain reaction (PCR) assay was applied to determine the effect of berberine hydrochloride on the mRNA expression levels of fos-related antigen 2 (Fra-2), tartrate-resistant acid phosphatase (TRAP), beta3-integrin, cathepsin K, dendritic cell-specific transmembrane protein (DC-STAMP), V-type proton ATPase subunit d 2 (Atp6v0d2) and NFATcl.	berberine chloride	79-102	fos-like antigen 2	Mus musculus	159-164
28849049-3	2017	A polymerase chain reaction (PCR) assay was applied to determine the effect of berberine hydrochloride on the mRNA expression levels of fos-related antigen 2 (Fra-2), tartrate-resistant acid phosphatase (TRAP), beta3-integrin, cathepsin K, dendritic cell-specific transmembrane protein (DC-STAMP), V-type proton ATPase subunit d 2 (Atp6v0d2) and NFATcl.	berberine chloride	79-102	acid phosphatase 5, tartrate resistant	Mus musculus	167-202
28849049-3	2017	A polymerase chain reaction (PCR) assay was applied to determine the effect of berberine hydrochloride on the mRNA expression levels of fos-related antigen 2 (Fra-2), tartrate-resistant acid phosphatase (TRAP), beta3-integrin, cathepsin K, dendritic cell-specific transmembrane protein (DC-STAMP), V-type proton ATPase subunit d 2 (Atp6v0d2) and NFATcl.	berberine chloride	79-102	acid phosphatase 5, tartrate resistant	Mus musculus	204-208
28849049-7	2017	The PCR results demonstrated that berberine hydrochloride inhibited the mRNA expression levels of Fra-2, TRAP, beta3-integrin, cathepsin K, DC-STAMP, Atp6v0d2 and NFATc1.	berberine chloride	34-57	fos-like antigen 2	Mus musculus	98-103
28849049-7	2017	The PCR results demonstrated that berberine hydrochloride inhibited the mRNA expression levels of Fra-2, TRAP, beta3-integrin, cathepsin K, DC-STAMP, Atp6v0d2 and NFATc1.	berberine chloride	34-57	acid phosphatase 5, tartrate resistant	Mus musculus	105-109
28849049-7	2017	The PCR results demonstrated that berberine hydrochloride inhibited the mRNA expression levels of Fra-2, TRAP, beta3-integrin, cathepsin K, DC-STAMP, Atp6v0d2 and NFATc1.	berberine chloride	34-57	cathepsin K	Mus musculus	127-138