PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30253244-3	2018	THS exposure generated from as low as the 10 cigarettes-smoking regimen, resulted in increased circulating inflammatory cytokines, tumor necrosis factor alpha, interleukin 1 alpha, and granulocyte macrophage colony-stimulating factor.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	tumor necrosis factor	Homo sapiens	131-158
30393232-4	2019	Under the induction of THS, gut barrier failure was characterized by injury of permeability and mucus layer, which were companied by the decreased expression of zonula occludens-1 in the colon and increased levels of inflammatory factors including tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-6, and IL-1beta in the serum.	THYMIDINE-5'-(DITHIO)PHOSPHATE	23-26	tumor necrosis factor	Rattus norvegicus	248-275
30393232-4	2019	Under the induction of THS, gut barrier failure was characterized by injury of permeability and mucus layer, which were companied by the decreased expression of zonula occludens-1 in the colon and increased levels of inflammatory factors including tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-6, and IL-1beta in the serum.	THYMIDINE-5'-(DITHIO)PHOSPHATE	23-26	interferon gamma	Rattus norvegicus	277-293
30393232-4	2019	Under the induction of THS, gut barrier failure was characterized by injury of permeability and mucus layer, which were companied by the decreased expression of zonula occludens-1 in the colon and increased levels of inflammatory factors including tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-6, and IL-1beta in the serum.	THYMIDINE-5'-(DITHIO)PHOSPHATE	23-26	interleukin 6	Rattus norvegicus	295-313
30393232-4	2019	Under the induction of THS, gut barrier failure was characterized by injury of permeability and mucus layer, which were companied by the decreased expression of zonula occludens-1 in the colon and increased levels of inflammatory factors including tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-6, and IL-1beta in the serum.	THYMIDINE-5'-(DITHIO)PHOSPHATE	23-26	interleukin 1 beta	Rattus norvegicus	319-327
30253244-3	2018	THS exposure generated from as low as the 10 cigarettes-smoking regimen, resulted in increased circulating inflammatory cytokines, tumor necrosis factor alpha, interleukin 1 alpha, and granulocyte macrophage colony-stimulating factor.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	interleukin 1 alpha	Homo sapiens	160-179
30253244-3	2018	THS exposure generated from as low as the 10 cigarettes-smoking regimen, resulted in increased circulating inflammatory cytokines, tumor necrosis factor alpha, interleukin 1 alpha, and granulocyte macrophage colony-stimulating factor.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	colony stimulating factor 2	Homo sapiens	185-233
29720175-14	2018	By contrast, the probability of appendectomy provision by THs was increased by performance-related payment (PRP).	THYMIDINE-5'-(DITHIO)PHOSPHATE	58-61	prion protein	Homo sapiens	108-111
29488614-6	2018	THS caused significant reductions in heart rate and mean arterial blood pressure, and was associated with significant increases in tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, p-p38MAPK, NF-kappaB and AP-1 activation, in addition to TLR4 expression, in the lung.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	tumor necrosis factor	Rattus norvegicus	131-158
29488614-6	2018	THS caused significant reductions in heart rate and mean arterial blood pressure, and was associated with significant increases in tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, p-p38MAPK, NF-kappaB and AP-1 activation, in addition to TLR4 expression, in the lung.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	interleukin 1 beta	Rattus norvegicus	180-188
29488614-6	2018	THS caused significant reductions in heart rate and mean arterial blood pressure, and was associated with significant increases in tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, p-p38MAPK, NF-kappaB and AP-1 activation, in addition to TLR4 expression, in the lung.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	toll-like receptor 4	Rattus norvegicus	247-251
27350053-12	2016	Thus, distinctions in the target organ and the TPO inhibitory potency between these chemicals are likely contributing to different reductions of maternal THs levels and affecting the potency to cause developmental toxicity and neurotoxicity.	THYMIDINE-5'-(DITHIO)PHOSPHATE	154-157	thyroid peroxidase	Homo sapiens	47-50
28487990-1	2017	The present study aimed to investigate the role of Bruton"s tyrosine kinase (BTK) in the pathogenesis of lung injury induced by trauma-hemorrhagic shock (THS), and to examine the pulmonary protective effects of BTK inhibition.	THYMIDINE-5'-(DITHIO)PHOSPHATE	154-157	Bruton tyrosine kinase	Rattus norvegicus	77-80
28487990-8	2017	BTK was notably activated in lungs of THS rats.	THYMIDINE-5'-(DITHIO)PHOSPHATE	38-41	Bruton tyrosine kinase	Rattus norvegicus	0-3
28487990-9	2017	BALF protein concentration, total leukocytes and eosinophils, peripheral blood expression levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and monocyte chemotactic protein 1 were significantly upregulated after THS induction, and each exhibited decreased expression upon LFM-A13 treatment.	THYMIDINE-5'-(DITHIO)PHOSPHATE	230-233	tumor necrosis factor	Rattus norvegicus	100-127
28487990-9	2017	BALF protein concentration, total leukocytes and eosinophils, peripheral blood expression levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and monocyte chemotactic protein 1 were significantly upregulated after THS induction, and each exhibited decreased expression upon LFM-A13 treatment.	THYMIDINE-5'-(DITHIO)PHOSPHATE	230-233	interleukin 1 beta	Rattus norvegicus	129-151
28487990-9	2017	BALF protein concentration, total leukocytes and eosinophils, peripheral blood expression levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and monocyte chemotactic protein 1 were significantly upregulated after THS induction, and each exhibited decreased expression upon LFM-A13 treatment.	THYMIDINE-5'-(DITHIO)PHOSPHATE	230-233	C-C motif chemokine ligand 2	Rattus norvegicus	162-192
28487990-10	2017	THS-induced interstitial hyperplasia, edema and neutrophilic infiltration in lungs were improved by the inhibition of BTK.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	Bruton tyrosine kinase	Rattus norvegicus	118-121
28487990-11	2017	In addition, THS-induced NO release, iNOS overexpression, and NF-kappaB and MAPK signaling were suppressed by BTK inhibition.	THYMIDINE-5'-(DITHIO)PHOSPHATE	13-16	nitric oxide synthase 2	Rattus norvegicus	37-41
28487990-11	2017	In addition, THS-induced NO release, iNOS overexpression, and NF-kappaB and MAPK signaling were suppressed by BTK inhibition.	THYMIDINE-5'-(DITHIO)PHOSPHATE	13-16	Bruton tyrosine kinase	Rattus norvegicus	110-113
28487990-12	2017	Results from the present study demonstrate that BTK may serve a pivotal role in the pathogenesis of THS-related lung injury, and the inhibition of BTK may significantly alleviate THS-induced lung damage.	THYMIDINE-5'-(DITHIO)PHOSPHATE	100-103	Bruton tyrosine kinase	Rattus norvegicus	48-51
28487990-12	2017	Results from the present study demonstrate that BTK may serve a pivotal role in the pathogenesis of THS-related lung injury, and the inhibition of BTK may significantly alleviate THS-induced lung damage.	THYMIDINE-5'-(DITHIO)PHOSPHATE	179-182	Bruton tyrosine kinase	Rattus norvegicus	147-150
29440622-6	2018	RNA sequencing analysis revealed that THS exposure induced endoplasmic reticulum stress and activated p53 signaling.	THYMIDINE-5'-(DITHIO)PHOSPHATE	38-41	transformation related protein 53, pseudogene	Mus musculus	102-105
28912356-5	2017	We found that THS exposure, as early as 1 month, resulted in increased circulating inflammatory cytokines, tumor necrosis factor by an order of magnitude of 2 and granulocyte macrophage colony-stimulating factor by an order of magnitude of 1.5 and in increases in the stress hormone epinephrine and the liver damage biomarker aspartate aminotransferase (AST), increased in magnitude 1.5 and 2.5 times compared with controls, respectively.	THYMIDINE-5'-(DITHIO)PHOSPHATE	14-17	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	326-352
28912356-5	2017	We found that THS exposure, as early as 1 month, resulted in increased circulating inflammatory cytokines, tumor necrosis factor by an order of magnitude of 2 and granulocyte macrophage colony-stimulating factor by an order of magnitude of 1.5 and in increases in the stress hormone epinephrine and the liver damage biomarker aspartate aminotransferase (AST), increased in magnitude 1.5 and 2.5 times compared with controls, respectively.	THYMIDINE-5'-(DITHIO)PHOSPHATE	14-17	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	354-357
26489853-6	2015	Glutathione metabolism in GC-2 cells, and nucleic acid and ammonia metabolism in TM-4 cells, was changed significantly by THS treatment.	THYMIDINE-5'-(DITHIO)PHOSPHATE	122-125	guanylate cyclase 2f	Mus musculus	26-30
26885630-4	2016	BET surface area study of C(F)@THS revealed the existence of a slit like mesoporosity with a surface area value of 81 m(2) g(-1).	THYMIDINE-5'-(DITHIO)PHOSPHATE	31-34	delta/notch like EGF repeat containing	Homo sapiens	0-3
26934053-5	2016	Using mice exposed to THS under conditions that mimic exposure of humans, we show that THS increases cellular oxidative stress by increasing superoxide dismutase (SOD) activity and hydrogen peroxide (H2O2) levels while reducing the activity of antioxidant enzymes catalase and glutathione peroxidase (GPx) that break down H2O2 into H2O and O2.	THYMIDINE-5'-(DITHIO)PHOSPHATE	87-90	catalase	Homo sapiens	264-272
26934053-9	2016	To determine whether these effects on THS-induced insulin resistance are due to increase in oxidative stress, we treated mice exposed to THS with the antioxidants N-acetyl cysteine (NAC) and alpha-tocopherol (alpha-toc) and showed that the oxidative stress, the molecular damage, and the insulin resistance, were significantly reversed.	THYMIDINE-5'-(DITHIO)PHOSPHATE	38-41	insulin	Homo sapiens	50-57
26934053-11	2016	In conclusion, THS exposure results in insulin resistance in the form of non-obese type II diabetes (NODII) through oxidative stress.	THYMIDINE-5'-(DITHIO)PHOSPHATE	15-18	insulin	Homo sapiens	39-46
25958090-1	2015	The thisbe (ths) gene encodes a Drosophila fibroblast growth factor (FGF), and mutant females are viable but sterile suggesting a link between FGF signaling and fertility.	THYMIDINE-5'-(DITHIO)PHOSPHATE	12-15	branchless	Drosophila melanogaster	43-67
25958090-1	2015	The thisbe (ths) gene encodes a Drosophila fibroblast growth factor (FGF), and mutant females are viable but sterile suggesting a link between FGF signaling and fertility.	THYMIDINE-5'-(DITHIO)PHOSPHATE	12-15	branchless	Drosophila melanogaster	69-72
25958090-1	2015	The thisbe (ths) gene encodes a Drosophila fibroblast growth factor (FGF), and mutant females are viable but sterile suggesting a link between FGF signaling and fertility.	THYMIDINE-5'-(DITHIO)PHOSPHATE	12-15	branchless	Drosophila melanogaster	143-146
23462851-11	2013	The long amplicon-quantitative PCR assay quantified significantly higher levels of oxidative DNA damage in hypoxanthine phosphoribosyltransferase 1 (HPRT) and polymerase beta (POLB) genes of cultured human cells exposed to chronic THS for 24h compared with untreated cells, suggesting that THS exposure is related to increased oxidative stress and could be an important contributing factor in THS-mediated toxicity.	THYMIDINE-5'-(DITHIO)PHOSPHATE	231-234	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	107-147
25090026-8	2014	In univariate analysis, high MYC/BCL2 DHS, high MYC/BCL6 DHS and high THS were associated with inferior OS and PFS in both CHOP and R-CHOP cohorts (P<0.05).	THYMIDINE-5'-(DITHIO)PHOSPHATE	70-73	DNA damage inducible transcript 3	Homo sapiens	123-127
25090026-11	2014	These data together suggest that the immunohistochemical DHSs and THS defined a large subset of DLBCLs with double-hit biology and was strongly associated with poor outcome in patients treated with R-CHOP or CHOP.	THYMIDINE-5'-(DITHIO)PHOSPHATE	66-69	DNA damage inducible transcript 3	Homo sapiens	208-212
24362320-1	2014	By isolating putative binding partners through the two-hybrid system (THS) we further extended the characterization of the specific interstrand cross-link (ICL) repair gene PSO2 of Saccharomyces cerevisiae.	THYMIDINE-5'-(DITHIO)PHOSPHATE	70-73	DNA cross-link repair protein PSO2	Saccharomyces cerevisiae S288C	173-177
24362320-2	2014	Nine fusion protein products were isolated for Pso2p using THS, among them the Sak1 kinase, which interacted with the C-terminal beta-CASP domain of Pso2p.	THYMIDINE-5'-(DITHIO)PHOSPHATE	59-62	DNA cross-link repair protein PSO2	Saccharomyces cerevisiae S288C	47-52
24362320-2	2014	Nine fusion protein products were isolated for Pso2p using THS, among them the Sak1 kinase, which interacted with the C-terminal beta-CASP domain of Pso2p.	THYMIDINE-5'-(DITHIO)PHOSPHATE	59-62	serine/threonine protein kinase SAK1	Saccharomyces cerevisiae S288C	79-83
24362320-2	2014	Nine fusion protein products were isolated for Pso2p using THS, among them the Sak1 kinase, which interacted with the C-terminal beta-CASP domain of Pso2p.	THYMIDINE-5'-(DITHIO)PHOSPHATE	59-62	DNA cross-link repair protein PSO2	Saccharomyces cerevisiae S288C	149-154
23462851-11	2013	The long amplicon-quantitative PCR assay quantified significantly higher levels of oxidative DNA damage in hypoxanthine phosphoribosyltransferase 1 (HPRT) and polymerase beta (POLB) genes of cultured human cells exposed to chronic THS for 24h compared with untreated cells, suggesting that THS exposure is related to increased oxidative stress and could be an important contributing factor in THS-mediated toxicity.	THYMIDINE-5'-(DITHIO)PHOSPHATE	231-234	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	149-153
23462851-11	2013	The long amplicon-quantitative PCR assay quantified significantly higher levels of oxidative DNA damage in hypoxanthine phosphoribosyltransferase 1 (HPRT) and polymerase beta (POLB) genes of cultured human cells exposed to chronic THS for 24h compared with untreated cells, suggesting that THS exposure is related to increased oxidative stress and could be an important contributing factor in THS-mediated toxicity.	THYMIDINE-5'-(DITHIO)PHOSPHATE	231-234	DNA polymerase beta	Homo sapiens	176-180
23462851-11	2013	The long amplicon-quantitative PCR assay quantified significantly higher levels of oxidative DNA damage in hypoxanthine phosphoribosyltransferase 1 (HPRT) and polymerase beta (POLB) genes of cultured human cells exposed to chronic THS for 24h compared with untreated cells, suggesting that THS exposure is related to increased oxidative stress and could be an important contributing factor in THS-mediated toxicity.	THYMIDINE-5'-(DITHIO)PHOSPHATE	290-293	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	149-153
23462851-11	2013	The long amplicon-quantitative PCR assay quantified significantly higher levels of oxidative DNA damage in hypoxanthine phosphoribosyltransferase 1 (HPRT) and polymerase beta (POLB) genes of cultured human cells exposed to chronic THS for 24h compared with untreated cells, suggesting that THS exposure is related to increased oxidative stress and could be an important contributing factor in THS-mediated toxicity.	THYMIDINE-5'-(DITHIO)PHOSPHATE	290-293	DNA polymerase beta	Homo sapiens	176-180
23462851-11	2013	The long amplicon-quantitative PCR assay quantified significantly higher levels of oxidative DNA damage in hypoxanthine phosphoribosyltransferase 1 (HPRT) and polymerase beta (POLB) genes of cultured human cells exposed to chronic THS for 24h compared with untreated cells, suggesting that THS exposure is related to increased oxidative stress and could be an important contributing factor in THS-mediated toxicity.	THYMIDINE-5'-(DITHIO)PHOSPHATE	290-293	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	149-153
23462851-11	2013	The long amplicon-quantitative PCR assay quantified significantly higher levels of oxidative DNA damage in hypoxanthine phosphoribosyltransferase 1 (HPRT) and polymerase beta (POLB) genes of cultured human cells exposed to chronic THS for 24h compared with untreated cells, suggesting that THS exposure is related to increased oxidative stress and could be an important contributing factor in THS-mediated toxicity.	THYMIDINE-5'-(DITHIO)PHOSPHATE	290-293	DNA polymerase beta	Homo sapiens	176-180
22219352-3	2012	The expression of the fibroblast growth factor receptor (FGFR) heartless and its ligands, pyramus (pyr) and thisbe (ths), within CVM and TVM cells, respectively, suggested FGF signaling may influence CVM cell guidance.	THYMIDINE-5'-(DITHIO)PHOSPHATE	116-119	breathless	Drosophila melanogaster	22-55
22609944-2	2012	In Drosophila, the FGF8-like ligands Pyramus (Pyr) and Thisbe (Ths), which signal through their receptor Heartless (Htl), are known to regulate early mesodermal cell migration after gastrulation as well as glial cell migration during eye development.	THYMIDINE-5'-(DITHIO)PHOSPHATE	63-66	pyramus	Drosophila melanogaster	37-44
22609944-2	2012	In Drosophila, the FGF8-like ligands Pyramus (Pyr) and Thisbe (Ths), which signal through their receptor Heartless (Htl), are known to regulate early mesodermal cell migration after gastrulation as well as glial cell migration during eye development.	THYMIDINE-5'-(DITHIO)PHOSPHATE	63-66	pyramus	Drosophila melanogaster	37-40
22219352-3	2012	The expression of the fibroblast growth factor receptor (FGFR) heartless and its ligands, pyramus (pyr) and thisbe (ths), within CVM and TVM cells, respectively, suggested FGF signaling may influence CVM cell guidance.	THYMIDINE-5'-(DITHIO)PHOSPHATE	116-119	breathless	Drosophila melanogaster	57-61
22219352-3	2012	The expression of the fibroblast growth factor receptor (FGFR) heartless and its ligands, pyramus (pyr) and thisbe (ths), within CVM and TVM cells, respectively, suggested FGF signaling may influence CVM cell guidance.	THYMIDINE-5'-(DITHIO)PHOSPHATE	116-119	branchless	Drosophila melanogaster	57-60
20162355-10	2010	In first and second bioreactor test cases, the addition of a pulsatile THS to the WSS resulted in opposite trends of ICAM-1 down-regulation and up-regulation, respectively.	THYMIDINE-5'-(DITHIO)PHOSPHATE	71-74	intercellular adhesion molecule 1	Homo sapiens	117-123
20472287-4	2010	More importantly, tumor homogenate supernatant (THS) could effectively release DOX from CPX2 while the plasma and liver homogenate supernatant (LHS) could not, which was confirmed by an in vivo test.	THYMIDINE-5'-(DITHIO)PHOSPHATE	48-51	complexin 2	Homo sapiens	88-92
22850641-8	2012	THS induction was associated with significantly increased plasma concentrations of Cr, AST, CPK, IL-6, IL-10, and TNF-alpha from the baseline values by two- to three-fold after the hemorrhage phase, and THS-induced mice demonstrated significantly increased histological injury scores.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	87-90
22850641-8	2012	THS induction was associated with significantly increased plasma concentrations of Cr, AST, CPK, IL-6, IL-10, and TNF-alpha from the baseline values by two- to three-fold after the hemorrhage phase, and THS-induced mice demonstrated significantly increased histological injury scores.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	cystin 1	Mus musculus	92-95
22850641-8	2012	THS induction was associated with significantly increased plasma concentrations of Cr, AST, CPK, IL-6, IL-10, and TNF-alpha from the baseline values by two- to three-fold after the hemorrhage phase, and THS-induced mice demonstrated significantly increased histological injury scores.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	interleukin 6	Mus musculus	97-101
22850641-8	2012	THS induction was associated with significantly increased plasma concentrations of Cr, AST, CPK, IL-6, IL-10, and TNF-alpha from the baseline values by two- to three-fold after the hemorrhage phase, and THS-induced mice demonstrated significantly increased histological injury scores.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	interleukin 10	Mus musculus	103-108
22850641-8	2012	THS induction was associated with significantly increased plasma concentrations of Cr, AST, CPK, IL-6, IL-10, and TNF-alpha from the baseline values by two- to three-fold after the hemorrhage phase, and THS-induced mice demonstrated significantly increased histological injury scores.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	tumor necrosis factor	Mus musculus	114-123
20162355-12	2010	Similarly, in first and second bioreactor test cases, the addition of a pulsatile THS to the WSS resulted in a VCAM-1 up-regulation.	THYMIDINE-5'-(DITHIO)PHOSPHATE	82-85	vascular cell adhesion molecule 1	Homo sapiens	111-117
20162355-13	2010	However, it has been previously shown that the addition of a cyclic THS to a high- or low-steady WSS resulted in a VCAM-1 down-regulation, indicating that the EC response to idealized mechanical stimuli (steady WSS and cyclic THS) is not comparable to physiological mechanical stimuli (unsteady WSS and pulsatile THS), even though in both situations the average magnitude of WSS and THS applied were similar.	THYMIDINE-5'-(DITHIO)PHOSPHATE	68-71	vascular cell adhesion molecule 1	Homo sapiens	115-121
15075295-2	2004	Here we identify two new FGF genes, thisbe (ths) and pyramus (pyr), which probably encode the elusive ligands for this receptor.	THYMIDINE-5'-(DITHIO)PHOSPHATE	44-47	branchless	Drosophila melanogaster	25-28
19604013-8	2009	The initial ICAM-1 upregulation, due to the WSS alone, was downregulated with the addition of a cyclic THS.	THYMIDINE-5'-(DITHIO)PHOSPHATE	103-106	intercellular adhesion molecule 1	Homo sapiens	12-18
19604013-9	2009	It was observed that the largest THS (0-12%) had the greatest reducing effect on the ICAM-1 upregulation.	THYMIDINE-5'-(DITHIO)PHOSPHATE	33-36	intercellular adhesion molecule 1	Homo sapiens	85-91
19158183-4	2009	Here we analyze the specificity of FGFR [Heartless (Htl) and Breathless (Btl)] activation by each of the FGF ligands [Pyramus (Pyr), Thisbe (Ths) and Branchless (Bnl)] in Drosophila.	THYMIDINE-5'-(DITHIO)PHOSPHATE	141-144	breathless	Drosophila melanogaster	35-39
19158183-4	2009	Here we analyze the specificity of FGFR [Heartless (Htl) and Breathless (Btl)] activation by each of the FGF ligands [Pyramus (Pyr), Thisbe (Ths) and Branchless (Bnl)] in Drosophila.	THYMIDINE-5'-(DITHIO)PHOSPHATE	141-144	branchless	Drosophila melanogaster	35-38
18029320-8	2007	IL-6, IL-10, lactate, and base excess levels in the THS group were significantly higher than those in the PHS and healthy control groups.	THYMIDINE-5'-(DITHIO)PHOSPHATE	52-55	interleukin 6	Homo sapiens	0-4
18029320-8	2007	IL-6, IL-10, lactate, and base excess levels in the THS group were significantly higher than those in the PHS and healthy control groups.	THYMIDINE-5'-(DITHIO)PHOSPHATE	52-55	interleukin 10	Homo sapiens	6-11
1477802-2	1992	Calmodulin concentrations in samples of total homogenate (TH) and total homogenate supernates (THS) of the infected equine uterine tube explants were significantly lower than respective measurements on noninfected controls.	THYMIDINE-5'-(DITHIO)PHOSPHATE	95-98	calmodulin-2	Equus caballus	0-10
9344905-2	1997	To clarify its role, a yeast two-hybrid system (ths) screening was utilized to identify Nef cellular partners.	THYMIDINE-5'-(DITHIO)PHOSPHATE	48-51	S100 calcium binding protein B	Homo sapiens	88-91
9344905-4	1997	HsN3 behaved as bona fide Nef partner in ths control crosses.	THYMIDINE-5'-(DITHIO)PHOSPHATE	41-44	proteasome 20S subunit beta 4	Homo sapiens	0-4
9344905-4	1997	HsN3 behaved as bona fide Nef partner in ths control crosses.	THYMIDINE-5'-(DITHIO)PHOSPHATE	41-44	S100 calcium binding protein B	Homo sapiens	26-29
1451349-10	1992	The PA present in cell cultures and THs was identified as of the u-PA type.	THYMIDINE-5'-(DITHIO)PHOSPHATE	36-39	plasminogen activator, urokinase	Mus musculus	65-69
9882353-6	1999	Plk1 behaved as a bona fide pp65 partner in THS control crosses, and the interaction was confirmed by in vitro binding experiments.	THYMIDINE-5'-(DITHIO)PHOSPHATE	44-47	polo like kinase 1	Homo sapiens	0-4
9374706-11	1997	Iberiotoxin (IBTX; 200 nM), a maxi-K+ channel antagonist, blocked the ET-1-induced THs and reduced STOC activity.	THYMIDINE-5'-(DITHIO)PHOSPHATE	83-86	endothelin-1	Cavia porcellus	70-74
7558625-7	1995	The THS-induced ultrastructural changes represent early mEC activation.	THYMIDINE-5'-(DITHIO)PHOSPHATE	4-7	chemokine (C-C motif) ligand 28	Mus musculus	56-59
34840990-3	2021	However, the roles played by TLR5 on intestinal barrier maintenance and commensal bacterial translocation post-THS are poorly understood.	THYMIDINE-5'-(DITHIO)PHOSPHATE	111-114	toll-like receptor 5	Mus musculus	29-33
34840990-4	2021	In this research, we established THS models in wild-type (WT) and Tlr5-/- (genetically deficient in TLR5 expression) mice.	THYMIDINE-5'-(DITHIO)PHOSPHATE	33-36	toll-like receptor 5	Mus musculus	66-70
34840990-4	2021	In this research, we established THS models in wild-type (WT) and Tlr5-/- (genetically deficient in TLR5 expression) mice.	THYMIDINE-5'-(DITHIO)PHOSPHATE	33-36	toll-like receptor 5	Mus musculus	100-104
35098703-3	2022	By the first time of pyramidal-patterned hydrogel fabrication method and laminated polydimethylsiloxane (PDMS) encapsulation process, the self-powered THS shows the advantages of remarkable flexibility, good transparency ( 85%), and excellent sensing performance, including extraordinary sensitivity (45.97 mV Pa-1 ), fast response ( 20 ms), very low limit of detection (50 Pa) as well as good stability (36 000 cycles).	THYMIDINE-5'-(DITHIO)PHOSPHATE	151-154	PAXIP1 associated glutamate rich protein 1	Homo sapiens	310-314
34171496-6	2021	IL-1ss, IL-6, and TNF-alpha levels were notably dampened with TXM loaded THs, and oxidative stress markers, measured as GSH and MDA, were significantly reduced.	THYMIDINE-5'-(DITHIO)PHOSPHATE	73-76	interleukin-6	Oryctolagus cuniculus	8-12
34171496-6	2021	IL-1ss, IL-6, and TNF-alpha levels were notably dampened with TXM loaded THs, and oxidative stress markers, measured as GSH and MDA, were significantly reduced.	THYMIDINE-5'-(DITHIO)PHOSPHATE	73-76	tumor necrosis factor	Oryctolagus cuniculus	18-27
34552120-5	2021	The level of phosphorylated Akt was reduced, whereas the amount of phosphorylated NF-kappaB p65 was augmented by THS.	THYMIDINE-5'-(DITHIO)PHOSPHATE	113-116	AKT serine/threonine kinase 1	Homo sapiens	28-31
34552120-5	2021	The level of phosphorylated Akt was reduced, whereas the amount of phosphorylated NF-kappaB p65 was augmented by THS.	THYMIDINE-5'-(DITHIO)PHOSPHATE	113-116	nuclear factor kappa B subunit 1	Homo sapiens	82-91
34552120-5	2021	The level of phosphorylated Akt was reduced, whereas the amount of phosphorylated NF-kappaB p65 was augmented by THS.	THYMIDINE-5'-(DITHIO)PHOSPHATE	113-116	RELA proto-oncogene, NF-kB subunit	Homo sapiens	92-95
34552120-9	2021	In conclusion, these results suggest that WZYZ activates the Akt pathway and inhibits the NF-kappaB pathway by acting on the upstream regulators, thereby improving spermatogenesis deficit induced by THS.	THYMIDINE-5'-(DITHIO)PHOSPHATE	199-202	AKT serine/threonine kinase 1	Homo sapiens	61-64
34552120-9	2021	In conclusion, these results suggest that WZYZ activates the Akt pathway and inhibits the NF-kappaB pathway by acting on the upstream regulators, thereby improving spermatogenesis deficit induced by THS.	THYMIDINE-5'-(DITHIO)PHOSPHATE	199-202	nuclear factor kappa B subunit 1	Homo sapiens	90-99
35095903-9	2021	We further demonstrated that EVs containing IL-10 mainly accumulated in the liver during THS, where they were captured by Kupffer cells and induced the expression of PTPN22.	THYMIDINE-5'-(DITHIO)PHOSPHATE	89-92	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	Mus musculus	166-172
35095903-11	2021	Therefore, our study indicates that MSC-EVs containing IL-10 alleviate THS-induced hepatic injury and may serve as a cell-free therapeutic approach for THS.	THYMIDINE-5'-(DITHIO)PHOSPHATE	71-74	interleukin 10	Mus musculus	55-60
35095903-11	2021	Therefore, our study indicates that MSC-EVs containing IL-10 alleviate THS-induced hepatic injury and may serve as a cell-free therapeutic approach for THS.	THYMIDINE-5'-(DITHIO)PHOSPHATE	152-155	interleukin 10	Mus musculus	55-60
33652180-11	2021	And the hub-site located on the CYP1A2 promoter was identified, which mediated the association between THS and decreased melatonin-level.	THYMIDINE-5'-(DITHIO)PHOSPHATE	103-106	ELAV like RNA binding protein 2	Homo sapiens	8-11
2737493-2	1989	The mean value of tactile ths (Pth) is 2.22 +/- 0.86 mA; while R2, R3 and pain threshold values are 1.25 +/- 0.34, 3.52 +/- 1.94 and 4.78 +/- 2.77 times the Pth respectively.	THYMIDINE-5'-(DITHIO)PHOSPHATE	26-29	parathyroid hormone	Homo sapiens	31-34
33652180-11	2021	And the hub-site located on the CYP1A2 promoter was identified, which mediated the association between THS and decreased melatonin-level.	THYMIDINE-5'-(DITHIO)PHOSPHATE	103-106	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	32-38
33652180-12	2021	Decreased peak of serum melatonin, increased ROS and reduced SOD and GSH-Px in pineal and liver, and elevated CYP1A2 expression in liver was also found in the THS-exposed mice.	THYMIDINE-5'-(DITHIO)PHOSPHATE	159-162	superoxide dismutase 1	Homo sapiens	61-64
33652180-12	2021	Decreased peak of serum melatonin, increased ROS and reduced SOD and GSH-Px in pineal and liver, and elevated CYP1A2 expression in liver was also found in the THS-exposed mice.	THYMIDINE-5'-(DITHIO)PHOSPHATE	159-162	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	110-116
33652180-14	2021	Overall, THS exposure is associated with abnormal melatonin catabolism through hypo-methylation of CYP1A2-promoter.	THYMIDINE-5'-(DITHIO)PHOSPHATE	9-12	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	99-105
33360692-6	2021	RESULTS: Using AR and HES alone had no significant effect on the coagulation function of THS rats, but the two in combination reduced the increases of thrombin time, prothrombin time, activated part thrombin time, international normalized ratio, fibrin degradation products, D-dimer and the decreases of platelet count and fibrinogen concentration induced by THS.	THYMIDINE-5'-(DITHIO)PHOSPHATE	359-362	ferredoxin reductase	Rattus norvegicus	15-17
33482612-7	2021	In addition, crocin greatly increased nuclear factor erythroid 2-related factor 2/heme oxygenase-1 level in liver tissues of THS rats.	THYMIDINE-5'-(DITHIO)PHOSPHATE	125-128	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-81
33482612-7	2021	In addition, crocin greatly increased nuclear factor erythroid 2-related factor 2/heme oxygenase-1 level in liver tissues of THS rats.	THYMIDINE-5'-(DITHIO)PHOSPHATE	125-128	heme oxygenase 1	Rattus norvegicus	82-98
33360692-7	2021	The CT and CFT were significantly reduced, whereas alpha and MCF were increased in the THS rats in AR + HES group.	THYMIDINE-5'-(DITHIO)PHOSPHATE	87-90	ferredoxin reductase	Rattus norvegicus	99-101
33360692-8	2021	The combination of AR and HES reversed the effect of THS on elevating platelet-derived microparticles and endothelial cell-derived microparticle levels.	THYMIDINE-5'-(DITHIO)PHOSPHATE	53-56	ferredoxin reductase	Rattus norvegicus	19-21
33654287-7	2021	Log2-fold comparison found differences between THS-polluted and THS-free homes for specific genera in samples from the built-environment (e.g., Acinetobacter, Bradyrhizobium, Corynebacterium, Gemella, Neisseria, Staphylococcus, Streptococcus, and Veillonella) and in samples from children (esp.	THYMIDINE-5'-(DITHIO)PHOSPHATE	47-50	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	290-293
33360692-10	2021	CONCLUSIONS: AR combined with HES has a significant protective effect on coagulation function of THS rats when the mean arterial pressure reaches 60 mmHg.	THYMIDINE-5'-(DITHIO)PHOSPHATE	97-100	ferredoxin reductase	Rattus norvegicus	13-15
32931469-4	2020	Here, three-dimensional (3D) self-assembled TiO2 hierarchical spheres (THS) prepared by a simple one-step hydrothermal method are employed as innovative support, and ultrafine high-density APO NPs with an average size of about 3 nm are successfully deposited and uniformly dispersed throughout THS to form hierarchical THS/APO composites.	THYMIDINE-5'-(DITHIO)PHOSPHATE	71-74	aminopeptidase O (putative)	Homo sapiens	189-192
33343806-11	2020	Meanwhile, THS induced expression of mitochondrial fission proteins Drp1 and Fis1 and decreased expression of mitochondrial fusion protein Mfn1 in vascular tissues.	THYMIDINE-5'-(DITHIO)PHOSPHATE	11-14	collapsin response mediator protein 1	Rattus norvegicus	68-72
33343806-11	2020	Meanwhile, THS induced expression of mitochondrial fission proteins Drp1 and Fis1 and decreased expression of mitochondrial fusion protein Mfn1 in vascular tissues.	THYMIDINE-5'-(DITHIO)PHOSPHATE	11-14	fission, mitochondrial 1	Rattus norvegicus	77-81
33343806-11	2020	Meanwhile, THS induced expression of mitochondrial fission proteins Drp1 and Fis1 and decreased expression of mitochondrial fusion protein Mfn1 in vascular tissues.	THYMIDINE-5'-(DITHIO)PHOSPHATE	11-14	mitofusin 1	Rattus norvegicus	139-143
32931469-4	2020	Here, three-dimensional (3D) self-assembled TiO2 hierarchical spheres (THS) prepared by a simple one-step hydrothermal method are employed as innovative support, and ultrafine high-density APO NPs with an average size of about 3 nm are successfully deposited and uniformly dispersed throughout THS to form hierarchical THS/APO composites.	THYMIDINE-5'-(DITHIO)PHOSPHATE	71-74	aminopeptidase O (putative)	Homo sapiens	323-326
32931469-5	2020	The novel THS/APO microstructure provides abundant reactive sites for photocatalytic reactions and promotes the photogenerated charge separation and transfer due to the ultrafine size of APO NPs and the TiO2/APO Type-II heterojunction.	THYMIDINE-5'-(DITHIO)PHOSPHATE	10-13	aminopeptidase O (putative)	Homo sapiens	14-17
32931469-5	2020	The novel THS/APO microstructure provides abundant reactive sites for photocatalytic reactions and promotes the photogenerated charge separation and transfer due to the ultrafine size of APO NPs and the TiO2/APO Type-II heterojunction.	THYMIDINE-5'-(DITHIO)PHOSPHATE	10-13	aminopeptidase O (putative)	Homo sapiens	187-190
32931469-5	2020	The novel THS/APO microstructure provides abundant reactive sites for photocatalytic reactions and promotes the photogenerated charge separation and transfer due to the ultrafine size of APO NPs and the TiO2/APO Type-II heterojunction.	THYMIDINE-5'-(DITHIO)PHOSPHATE	10-13	aminopeptidase O (putative)	Homo sapiens	187-190
32931469-6	2020	As a result, the THS/APO composites show significant improvement in photocatalytic activity and stability in methylene blue (MB) degradation.	THYMIDINE-5'-(DITHIO)PHOSPHATE	17-20	aminopeptidase O (putative)	Homo sapiens	21-24
32931469-7	2020	The reaction constant of THS/APO composites far exceeds that of either THS or APO, roughly 16 and 7 times higher than that of THS and APO under full-spectrum light, and 41 and 4 times higher under visible light.	THYMIDINE-5'-(DITHIO)PHOSPHATE	25-28	aminopeptidase O (putative)	Homo sapiens	29-32
32931469-7	2020	The reaction constant of THS/APO composites far exceeds that of either THS or APO, roughly 16 and 7 times higher than that of THS and APO under full-spectrum light, and 41 and 4 times higher under visible light.	THYMIDINE-5'-(DITHIO)PHOSPHATE	25-28	aminopeptidase O (putative)	Homo sapiens	78-81
32931469-7	2020	The reaction constant of THS/APO composites far exceeds that of either THS or APO, roughly 16 and 7 times higher than that of THS and APO under full-spectrum light, and 41 and 4 times higher under visible light.	THYMIDINE-5'-(DITHIO)PHOSPHATE	25-28	aminopeptidase O (putative)	Homo sapiens	78-81
32931469-7	2020	The reaction constant of THS/APO composites far exceeds that of either THS or APO, roughly 16 and 7 times higher than that of THS and APO under full-spectrum light, and 41 and 4 times higher under visible light.	THYMIDINE-5'-(DITHIO)PHOSPHATE	71-74	aminopeptidase O (putative)	Homo sapiens	29-32
32931469-7	2020	The reaction constant of THS/APO composites far exceeds that of either THS or APO, roughly 16 and 7 times higher than that of THS and APO under full-spectrum light, and 41 and 4 times higher under visible light.	THYMIDINE-5'-(DITHIO)PHOSPHATE	71-74	aminopeptidase O (putative)	Homo sapiens	29-32
32934667-8	2020	TNIP2 represents a direct target of miR-15a-5p, and it was downregulated in both patients with THS and the THS rat model.	THYMIDINE-5'-(DITHIO)PHOSPHATE	95-98	TNFAIP3 interacting protein 2	Homo sapiens	0-5
32934667-8	2020	TNIP2 represents a direct target of miR-15a-5p, and it was downregulated in both patients with THS and the THS rat model.	THYMIDINE-5'-(DITHIO)PHOSPHATE	107-110	TNFAIP3 interacting protein 2	Homo sapiens	0-5
32934667-12	2020	Moreover, it was demonstrated that all the effects of miR-15a-5p on THS rats were ablated following TNIP2 silencing.	THYMIDINE-5'-(DITHIO)PHOSPHATE	68-71	TNFAIP3 interacting protein 2	Rattus norvegicus	100-105
32934667-13	2020	Taken together, the data of the current study indicate that miR-15a-5p downregulation serves a protective role in THS-induced acute lung injury via directly targeting TNIP2.	THYMIDINE-5'-(DITHIO)PHOSPHATE	114-117	TNFAIP3 interacting protein 2	Rattus norvegicus	167-172
32750045-10	2020	THS-induced over-production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in BALF and serum was suppressed by MaR1.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	interleukin 6	Rattus norvegicus	31-44
32750045-10	2020	THS-induced over-production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in BALF and serum was suppressed by MaR1.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	interleukin 6	Rattus norvegicus	46-50
32750045-10	2020	THS-induced over-production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in BALF and serum was suppressed by MaR1.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	tumor necrosis factor	Rattus norvegicus	56-83
32750045-10	2020	THS-induced over-production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in BALF and serum was suppressed by MaR1.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	tumor necrosis factor	Rattus norvegicus	85-94
32750045-11	2020	Besides, the TLR4/p38MAPK/NF-kappaB pathway activation in THS-induced rats were inhibited by MaR1 treatment.	THYMIDINE-5'-(DITHIO)PHOSPHATE	58-61	toll-like receptor 4	Rattus norvegicus	13-17
32750045-12	2020	CONCLUSIONS Our study showed that MaR1 could effectively alleviated THS-induced lung injury via inhibiting the excitation of the TLR4/p38MAPK/NF-kappaB pathway in THS-induced rats, suggesting that MaR1 might be a novel agent for lung damage treatment.	THYMIDINE-5'-(DITHIO)PHOSPHATE	68-71	toll-like receptor 4	Rattus norvegicus	129-133
32750045-12	2020	CONCLUSIONS Our study showed that MaR1 could effectively alleviated THS-induced lung injury via inhibiting the excitation of the TLR4/p38MAPK/NF-kappaB pathway in THS-induced rats, suggesting that MaR1 might be a novel agent for lung damage treatment.	THYMIDINE-5'-(DITHIO)PHOSPHATE	163-166	toll-like receptor 4	Rattus norvegicus	129-133
33204648-4	2020	Results: Data from four preclinical mouse and rat studies showed that, upon either cessation of cigarette smoke exposure or switching to THS exposure, the upregulation of CYP1A2 observed with exposure to cigarette smoke reverted close to fresh-air levels.	THYMIDINE-5'-(DITHIO)PHOSPHATE	137-140	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	171-177
33204648-7	2020	Conclusions: Because smoking cessation and switching to either electronic cigarettes or THS seem to have similar effects on CYP1A2 activity, the same measures taken for patients treated with narrow therapeutic index drugs that are metabolized by CYP1A2 and who quit smoking should be recommended for those switching to RRPs.	THYMIDINE-5'-(DITHIO)PHOSPHATE	88-91	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	124-130
32267018-6	2020	Key DNA damage response proteins including RPA, ATR, ATM, CHK1, and BRCA1 were activated in lung cells exposed to THS, consistent with replication stress.	THYMIDINE-5'-(DITHIO)PHOSPHATE	114-117	replication protein A1	Homo sapiens	43-46
32267018-6	2020	Key DNA damage response proteins including RPA, ATR, ATM, CHK1, and BRCA1 were activated in lung cells exposed to THS, consistent with replication stress.	THYMIDINE-5'-(DITHIO)PHOSPHATE	114-117	ATR serine/threonine kinase	Homo sapiens	48-51
32267018-6	2020	Key DNA damage response proteins including RPA, ATR, ATM, CHK1, and BRCA1 were activated in lung cells exposed to THS, consistent with replication stress.	THYMIDINE-5'-(DITHIO)PHOSPHATE	114-117	ATM serine/threonine kinase	Homo sapiens	53-56
32267018-6	2020	Key DNA damage response proteins including RPA, ATR, ATM, CHK1, and BRCA1 were activated in lung cells exposed to THS, consistent with replication stress.	THYMIDINE-5'-(DITHIO)PHOSPHATE	114-117	checkpoint kinase 1	Homo sapiens	58-62
32267018-6	2020	Key DNA damage response proteins including RPA, ATR, ATM, CHK1, and BRCA1 were activated in lung cells exposed to THS, consistent with replication stress.	THYMIDINE-5'-(DITHIO)PHOSPHATE	114-117	BRCA1 DNA repair associated	Homo sapiens	68-73