PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30706146-3	2019	Here, kinetics and thermodynamics of fluoride and azide binding to ferric human Hb (Hb(III)) complexed with the human Hp phenotypes 1-1 and 2-2 (Hp1-1:Hb(III) and Hp2-2:Hb(III), respectively) are reported (pH 7.0 and 20.0  C).	Ferric enterobactin ion	67-73	chromobox 5	Homo sapiens	145-150
29891307-5	2018	Antioxidant assay showed that ALP-1 exhibited strong DPPH and HO scavenging activities, as well as ferric-reducing antioxidant power.	Ferric enterobactin ion	99-105	asparaginase and isoaspartyl peptidase 1	Homo sapiens	30-35
30612358-5	2019	HgCl2 treatment resulted in oxidation of ferrous iron of hemoglobin to ferric form giving methemoglobin which is inactive as an oxygen transporter.	Ferric enterobactin ion	71-77	hemoglobin subunit gamma 2	Homo sapiens	90-103
29088986-4	2018	TAC was determined simultaneously with two methods (ferric reducing ability of plasma - FRAP, 2.2-diphenyl-1-picryl-hydrazyl - DPPH and countertypes for saliva - FRAS and DPPHS test), with and without UA (native TAC and Nu-TAC, respectively).	Ferric enterobactin ion	52-58	mechanistic target of rapamycin kinase	Homo sapiens	88-92
30202000-5	2018	Here, we show that transferrin containing ferric ion could be an ideal thermosensitizer for the increased efficiency of radiofrequency hyperthermia.	Ferric enterobactin ion	42-48	transferrin	Mus musculus	19-30
29690623-6	2018	Nu-TAC was assessed simultaneously with two methods in plasma (Ferric Reducing Ability of Plasma:Nu-FRAP, 2.2-diphenyl-1-picryl-hydrazyl:Nu-DPPH) and in saliva (Nu-FRAS and Nu-DPPHS test).	Ferric enterobactin ion	63-69	mechanistic target of rapamycin kinase	Homo sapiens	100-104
29659799-3	2018	Using the Miller assay it was determined that under low iron availability exposure to sub-inhibitory doses of hepcidin (4-12muM) led to 2-fold and 4-fold increases in the expression of ftnA and bfd, respectively (P < 0.05), in both a wild type (WT) and Deltafur (ferric uptake regulator) background.	Ferric enterobactin ion	266-272	hepcidin antimicrobial peptide	Homo sapiens	110-118
29659799-3	2018	Using the Miller assay it was determined that under low iron availability exposure to sub-inhibitory doses of hepcidin (4-12muM) led to 2-fold and 4-fold increases in the expression of ftnA and bfd, respectively (P < 0.05), in both a wild type (WT) and Deltafur (ferric uptake regulator) background.	Ferric enterobactin ion	266-272	ADAM metallopeptidase domain 1A (pseudogene)	Homo sapiens	185-189
29457669-6	2018	NAC also diminished the malathion-induced DNA fragmentation along with significantly reduction in oxidative stress parameters causing decrease in lipid peroxidation and enhancement of ferric reducing antioxidant power within testicular germ cells.	Ferric enterobactin ion	184-190	synuclein alpha	Homo sapiens	0-3
29488201-5	2018	A low operational cost of 0.35 $ m-3 was achieved because pH adjustment and iron-containing sludge disposal could be avoided since a total COD and color removal efficiency of 85 and 79% could be achieved at an original pH of 6.8 by the above sequential process with a ferric ion concentration below 0.8 mg L-1 after the Fe0/H2O2 reaction.	Ferric enterobactin ion	268-274	L1 cell adhesion molecule	Homo sapiens	306-309
28473297-0	2018	NADH reduction of nitroaromatics as a probe for residual ferric form high-spin in a cytochrome P450.	Ferric enterobactin ion	57-63	spindlin 1	Homo sapiens	74-78
29138269-9	2018	By contrast, the effect of cinaciguat on 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one-oxidized (ferric) sGC was moderate, reaching ~10%-15% of maximal activity.	Ferric enterobactin ion	96-102	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	104-107
28473297-0	2018	NADH reduction of nitroaromatics as a probe for residual ferric form high-spin in a cytochrome P450.	Ferric enterobactin ion	57-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	84-99
29209355-4	2017	The trivalent ferric cation (at 10 mM) proved to be essential for promoting flocculation under weak alkaline conditions (pH ~8.5), with a maximum efficiency that exceeded 95 and 85% for wild-type CC1690 and the cell wall-deficient sta6 mutant, respectively.	Ferric enterobactin ion	14-20	uncharacterized protein	Chlamydomonas reinhardtii	231-235
29035597-6	2018	Higher ferric reducing ability of plasma (FRAP) levels were measured after exercise with CQA coffee versus placebo (p = .01).	Ferric enterobactin ion	7-13	mechanistic target of rapamycin kinase	Homo sapiens	42-46
29185409-1	2017	Methemoglobin (MetHb) is a form of hemoglobin which contains iron in ferric state.	Ferric enterobactin ion	69-75	hemoglobin subunit gamma 2	Homo sapiens	0-13
29185409-1	2017	Methemoglobin (MetHb) is a form of hemoglobin which contains iron in ferric state.	Ferric enterobactin ion	69-75	hemoglobin subunit gamma 2	Homo sapiens	15-20
28759066-0	2017	Structural changes and picosecond to second dynamics of cytochrome c in interaction with nitric oxide in ferrous and ferric redox states.	Ferric enterobactin ion	117-123	cytochrome c, somatic	Homo sapiens	56-68
29027792-1	2017	Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible structure, particularly in the ferric form, such that it is able to sample a broad conformational space.	Ferric enterobactin ion	123-129	cytochrome c, somatic	Canis lupus familiaris	0-12
29027792-1	2017	Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible structure, particularly in the ferric form, such that it is able to sample a broad conformational space.	Ferric enterobactin ion	123-129	cytochrome c, somatic	Canis lupus familiaris	14-19
28991453-3	2017	This work provides detailed information about the active site structure of CYP11A1 in the resting state and substrate-bound ferric forms as well as the CO-ligated adducts.	Ferric enterobactin ion	124-130	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	75-82
28991453-8	2017	While this work shows that Adx has an only weak effect on ferric and ferrous CO states, it has a relatively stronger impact on the Fe-O-O fragments of the functionally relevant oxy complexes.	Ferric enterobactin ion	58-64	ferredoxin 1	Homo sapiens	27-30
28715687-7	2018	DPTB-TMS is highly efficient for the detection of ferric ions even in the presence of other metal ions.	Ferric enterobactin ion	50-56	PYD and CARD domain containing	Homo sapiens	5-8
28753305-4	2017	In this study, we report that cuprous oxide nanoparticles (Cu2O NPs) possess cytochrome c oxidase (CcO)-like activity and catalyze the oxidation of cytochrome c (Cyt c), converting it from the ferrous state to the ferric state under atmospheric oxygen conditions.	Ferric enterobactin ion	214-220	cytochrome c, somatic	Homo sapiens	77-89
28753305-4	2017	In this study, we report that cuprous oxide nanoparticles (Cu2O NPs) possess cytochrome c oxidase (CcO)-like activity and catalyze the oxidation of cytochrome c (Cyt c), converting it from the ferrous state to the ferric state under atmospheric oxygen conditions.	Ferric enterobactin ion	214-220	cytochrome c, somatic	Homo sapiens	148-160
28220853-1	2017	For the first time, renewable and easy accessible pre-bleached spent coffee powder coated with polyethylenimine (PEI) and ferric ions (Coffee-PEI-Fe) was used for the successive adsorption of As(V), Cu(II) and P(V) ions from spiked water samples.	Ferric enterobactin ion	122-128	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	192-197
28685208-4	2017	Both ferric and ferrous ions could significantly enhance the activity of MAO-B, instead of MAO-A, in SH-SY5Y cells.	Ferric enterobactin ion	5-11	monoamine oxidase B	Homo sapiens	73-78
28685208-4	2017	Both ferric and ferrous ions could significantly enhance the activity of MAO-B, instead of MAO-A, in SH-SY5Y cells.	Ferric enterobactin ion	5-11	monoamine oxidase A	Homo sapiens	91-96
28281709-0	2017	Magnetostructural relationship for mu2-phenoxido bridged ferric dimers.	Ferric enterobactin ion	57-63	adaptor related protein complex 1 subunit mu 2	Homo sapiens	35-38
28562754-6	2017	Biochemical analyses during the acute phase showed increased ferric-reducing ability of plasma (FRAP) and glutathione (GSH) levels in the vitamin C and C/E groups.	Ferric enterobactin ion	61-67	mechanistic target of rapamycin kinase	Mus musculus	96-100
28687456-6	2017	Markers of OS [4-hydroxynonenol (4-HNE), malondialdehyde (MDA) and serum SOD (S-SOD)] and antioxidant status [ferric reducing the ability of plasma (FRAP), Glutathione peroxidase (GPX) and Vitamin C (Vit C)] were measured in quiescent phase and during an episode of pancreatitis.	Ferric enterobactin ion	110-116	mechanistic target of rapamycin kinase	Homo sapiens	149-153
27842254-1	2017	A novel biomimetic drug delivery system (BDDS) inspired by the pH-dependent ferric ion-transport and release manner of transferrin (Tf) was developed for combating multidrug-resistant breast cancer.	Ferric enterobactin ion	76-82	transferrin	Homo sapiens	119-130
27267282-1	2016	A novel rhodamine-based dual probe Rh-2 for trivalent ferric ions (Fe(3+)) was successfully designed and synthesized, which exhibited a highly sensitive and selective recognition towards Fe(3+) with an enhanced fluorescence emission in methanol-water media (v/v=7/3, pH=7.2).	Ferric enterobactin ion	54-60	Rh associated glycoprotein	Homo sapiens	35-39
27343172-2	2016	Oxidation of thiocyanate to hypothiocyanite mediated by the redox intermediate Compound I rapidly restores the ferric state of MPO.	Ferric enterobactin ion	111-117	myeloperoxidase	Homo sapiens	127-130
27343172-4	2016	The reaction of ferric MPO with hypothiocyanite directly forms the MPO-cyanide complex, whereas a transient product derived from the reaction between hypothiocyanite and hydrogen peroxide is demonstrated to mediate the conversion of ferric MPO to Compound II.	Ferric enterobactin ion	16-22	myeloperoxidase	Homo sapiens	23-26
27343172-4	2016	The reaction of ferric MPO with hypothiocyanite directly forms the MPO-cyanide complex, whereas a transient product derived from the reaction between hypothiocyanite and hydrogen peroxide is demonstrated to mediate the conversion of ferric MPO to Compound II.	Ferric enterobactin ion	16-22	myeloperoxidase	Homo sapiens	67-70
27343172-4	2016	The reaction of ferric MPO with hypothiocyanite directly forms the MPO-cyanide complex, whereas a transient product derived from the reaction between hypothiocyanite and hydrogen peroxide is demonstrated to mediate the conversion of ferric MPO to Compound II.	Ferric enterobactin ion	16-22	myeloperoxidase	Homo sapiens	67-70
27343172-4	2016	The reaction of ferric MPO with hypothiocyanite directly forms the MPO-cyanide complex, whereas a transient product derived from the reaction between hypothiocyanite and hydrogen peroxide is demonstrated to mediate the conversion of ferric MPO to Compound II.	Ferric enterobactin ion	233-239	myeloperoxidase	Homo sapiens	23-26
27343172-4	2016	The reaction of ferric MPO with hypothiocyanite directly forms the MPO-cyanide complex, whereas a transient product derived from the reaction between hypothiocyanite and hydrogen peroxide is demonstrated to mediate the conversion of ferric MPO to Compound II.	Ferric enterobactin ion	233-239	myeloperoxidase	Homo sapiens	67-70
27343172-4	2016	The reaction of ferric MPO with hypothiocyanite directly forms the MPO-cyanide complex, whereas a transient product derived from the reaction between hypothiocyanite and hydrogen peroxide is demonstrated to mediate the conversion of ferric MPO to Compound II.	Ferric enterobactin ion	233-239	myeloperoxidase	Homo sapiens	67-70
27441502-1	2016	To improve the selectivity, delivery, and activity of ferric (Fe) anticancer agents, we design prodrugs based on N-donor residues of the human serum albumin (HSA) carrier IIA subdomain.	Ferric enterobactin ion	54-60	albumin	Homo sapiens	143-162
27402851-5	2016	The use of a polarized electrode to efficiently interconvert the ferric (Fe(3+)) and ferrous (Fe(2+)) forms of an immobilized NGB showed that the disulfide bridge both defines the kinetics of NO dioxygenase activity and regulates appearance of the free ferrous deoxy-NGB, which is the redox active form of the protein in contrast to oxy-NGB.	Ferric enterobactin ion	65-71	neuroglobin	Homo sapiens	126-129
27022137-1	2016	In this study, we investigated the effects of paraoxonase 1 (PON1) activities and the variant PON1-Q192R on the ferric reducing ability of plasma (FRAP) and total thiol.	Ferric enterobactin ion	112-118	paraoxonase 1	Homo sapiens	94-98
27022137-1	2016	In this study, we investigated the effects of paraoxonase 1 (PON1) activities and the variant PON1-Q192R on the ferric reducing ability of plasma (FRAP) and total thiol.	Ferric enterobactin ion	112-118	mechanistic target of rapamycin kinase	Homo sapiens	147-151
26935256-2	2016	Therefore, our group aimed to evaluate the correlation between the adipokines (adiponectin and leptin) and the oxidative stress marker malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) and antioxidant activity of plasma [ferric reducing ability of plasma (FRAP)] in healthy pregnant women and patients with gestational hypertension and pre-eclampsia.	Ferric enterobactin ion	239-245	adiponectin, C1Q and collagen domain containing	Homo sapiens	79-90
26868517-0	2016	Concentration of MS2 phage in river water by a combined ferric colloid adsorption and foam separation-based method, with MS2 phage leaching from ferric colloid.	Ferric enterobactin ion	56-62	MS2	Homo sapiens	17-20
26868517-0	2016	Concentration of MS2 phage in river water by a combined ferric colloid adsorption and foam separation-based method, with MS2 phage leaching from ferric colloid.	Ferric enterobactin ion	145-151	MS2	Homo sapiens	17-20
27651951-6	2016	The ferric reducing ability of plasma (FRAP) was considered to be an antioxidant power of human plasma.	Ferric enterobactin ion	4-10	mechanistic target of rapamycin kinase	Homo sapiens	39-43
26868517-0	2016	Concentration of MS2 phage in river water by a combined ferric colloid adsorption and foam separation-based method, with MS2 phage leaching from ferric colloid.	Ferric enterobactin ion	145-151	MS2	Homo sapiens	121-124
26995402-6	2016	In the presence of Alpha-hemoglobin stabilizing protein (AHSP), which stabilizes the alpha-subunit in a redox inactive hexacoordinate conformation (thus unable to undergo the redox ferric/ferryl transition), Cys93 oxidation was substantially reduced in both proteins.	Ferric enterobactin ion	181-187	alpha hemoglobin stabilizing protein	Homo sapiens	19-55
26995402-6	2016	In the presence of Alpha-hemoglobin stabilizing protein (AHSP), which stabilizes the alpha-subunit in a redox inactive hexacoordinate conformation (thus unable to undergo the redox ferric/ferryl transition), Cys93 oxidation was substantially reduced in both proteins.	Ferric enterobactin ion	181-187	alpha hemoglobin stabilizing protein	Homo sapiens	57-61
27283901-9	2016	The mechanism underlying this effect is that tyrosinase promotes melanin production and ferric ion adsorption only in hTERT-expressing cells.	Ferric enterobactin ion	88-94	tyrosinase	Homo sapiens	45-55
27101151-1	2016	Although the interaction of low-spin ferric complexes with nitric oxide has been well studied, examples of stable high-spin ferric nitrosyls (such as those that could be expected to form at typical non-heme iron sites in biology) are extremely rare.	Ferric enterobactin ion	124-130	spindlin 1	Homo sapiens	119-123
26868517-3	2016	When ferric colloid adsorption was performed prior to foam separation, MS2 phage was effectively removed from river water and concentrated in the generated foam within 7 min.	Ferric enterobactin ion	5-11	MS2	Homo sapiens	71-74
26868517-5	2016	Furthermore, based on the analysis of the collected ferric colloid dissolved using deferoxamine, the MS2 concentration in the colloid-dissolved solution was 190-fold higher than that found in raw water according to RT-qPCR analysis.	Ferric enterobactin ion	52-58	MS2	Homo sapiens	101-104
27243218-10	2016	Furthermore, the concentrations of nitric oxide, nitrite, nitrate, and the ferric reducing ability of plasma decreased with AAC indicating a lower oxidative stress status.	Ferric enterobactin ion	75-81	glycine N-acyltransferase	Bos taurus	124-127
27508376-7	2016	Phosphorus removal was significantly enhanced, exceeding 90% in E-BF by chemical precipitation, physical adsorption, and flocculation of phosphorus because of the in situ formation of ferric ions by the anodizing of sacrificial iron anodes.	Ferric enterobactin ion	184-190	EBF transcription factor 1	Homo sapiens	64-68
26722635-0	2015	Tyrosine modification increases the affinity of gastrin for ferric ions.	Ferric enterobactin ion	60-66	gastrin	Homo sapiens	48-55
27119042-1	2016	A ratiometric probe for determining ferric ions (Fe(3+)) was developed based on nitrogen-doped carbon dots (CDs) and rhodamine B isothiocyanate (RhB), which was then applied to selective detection of Fe(3+) in PB buffer solution, lake water, and tap water.	Ferric enterobactin ion	36-42	filamin B	Homo sapiens	246-249
26329855-4	2015	It is noteworthy that the Y48pCMF mutation significantly destabilizes the Fe-Met bond in the ferric form of cytochrome c, thereby lowering the pKa value for the alkaline transition of the heme-protein.	Ferric enterobactin ion	93-99	cytochrome c, somatic	Homo sapiens	108-120
26041225-4	2015	Protein hydrolysates from HT IPP showed no ORAC, superoxide or hydroxyl scavenging activity but had significantly (P<0.05) improved (80%) ferric reducing antioxidant power.	Ferric enterobactin ion	141-147	intracisternal A particle-promoted polypeptide	Homo sapiens	29-32
26457677-1	2015	The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated forms of the hormone.	Ferric enterobactin ion	38-44	gastrin	Homo sapiens	20-27
26457677-6	2015	We conclude that gastrin selectively binds two In3+ or Ru3+ ions, and that the affinity of the first site for In3+ or Ru3+ ions is higher than for ferric ions.	Ferric enterobactin ion	147-153	gastrin	Homo sapiens	17-24
26346916-1	2015	Electron transport (ETp) across met-myoglobin (m-Mb), as measured in a solid-state-like configuration between two electronic contacts, increases by up to 20 fold if Mb is covalently bound to one of the contacts, a Si electrode, in an oriented manner by its hemin (ferric) group, rather than in a non-oriented manner.	Ferric enterobactin ion	264-270	myoglobin	Homo sapiens	36-45
26664465-2	2015	Cerium ionic radius and its binding properties are similar to ferric ions, which may be bound to transferrin.	Ferric enterobactin ion	62-68	transferrin	Homo sapiens	97-108
25656940-2	2015	Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1) facilitating the export of iron from cells.	Ferric enterobactin ion	87-93	ceruloplasmin	Rattus norvegicus	0-13
26051633-5	2015	Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio.	Ferric enterobactin ion	123-129	CD4 molecule	Homo sapiens	25-28
26051633-5	2015	Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio.	Ferric enterobactin ion	123-129	CD8a molecule	Homo sapiens	29-32
26091015-4	2015	We show here that addition of NEt3 indeed allows the deprotonation of these ligands, the resulting complexes bearing either anilide or benzimidazolide that are coordinated to the ferric site.	Ferric enterobactin ion	179-185	tetraspanin 2	Homo sapiens	30-34
25656940-2	2015	Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1) facilitating the export of iron from cells.	Ferric enterobactin ion	87-93	ceruloplasmin	Rattus norvegicus	15-17
25656940-2	2015	Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1) facilitating the export of iron from cells.	Ferric enterobactin ion	87-93	solute carrier family 40 member 1	Rattus norvegicus	136-139
26785343-2	2015	Ceruloplasmin (Cp), an acute phase reactant protein that can convert ferrous iron to its less reactive ferric form facilitating binding to ferritin, has ferroxidase activity that is important to iron handling.	Ferric enterobactin ion	103-109	ceruloplasmin	Homo sapiens	0-13
25529660-0	2015	A universally calibrated microplate ferric reducing antioxidant power (FRAP) assay for foods and applications to Manuka honey.	Ferric enterobactin ion	36-42	mechanistic target of rapamycin kinase	Mus musculus	71-75
25792380-1	2015	Human serum transferrin (hTf) transports ferric ions in the blood stream and delivers them to cells via receptor-mediated endocytosis.	Ferric enterobactin ion	41-47	transferrin	Homo sapiens	12-23
25666609-7	2015	Spectroscopic analysis of the recombinant GLB-33 GD showed that the heme is pentacoordinate when ferrous and in the hydroxide-ligated form when ferric, even at neutral pH.	Ferric enterobactin ion	144-150	GLoBin related	Caenorhabditis elegans	42-48
25498622-5	2015	The antioxidant properties of the beta-C/M were investigated by the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method and ferric reducing antioxidant power (FRAP) method, respectively.	Ferric enterobactin ion	117-123	colony stimulating factor 2 receptor subunit beta	Homo sapiens	34-40
25152357-4	2014	RESULTS: Revised enzymatic kinetics for ceruloplasmin (Vmax 35muMFe(3+)/min/muM; Km 15muM) are provided under physiological conditions, and inhibition by sodium azide (Ki for Ferric Gain 78.3muM, Ki for transferrin loading 8.1x10(4)muM) is quantified.	Ferric enterobactin ion	175-181	ceruloplasmin	Homo sapiens	40-53
25635662-0	2015	Interplay between inhibitory ferric and stimulatory curcumin regulates phosphorylation-dependent human cystic fibrosis transmembrane conductance regulator and DeltaF508 activity.	Ferric enterobactin ion	29-35	CF transmembrane conductance regulator	Homo sapiens	103-154
25127743-2	2014	Reduction of dietary iron from the ferric to the ferrous form is required for uptake by solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) into the enterocytes.	Ferric enterobactin ion	35-41	solute carrier family 11 member 2	Homo sapiens	173-180
25506715-1	2015	The first step in the enzymatic cycle of mammalian peroxidases, including lactoperoxidase (LPO), is binding of hydrogen peroxide to the ferric resting state to form a ferric-hydroperoxo intermediate designated as Compound 0, the residual proton temporarily associating with the distal pocket His109 residue.	Ferric enterobactin ion	136-142	lactoperoxidase	Homo sapiens	74-89
25506715-1	2015	The first step in the enzymatic cycle of mammalian peroxidases, including lactoperoxidase (LPO), is binding of hydrogen peroxide to the ferric resting state to form a ferric-hydroperoxo intermediate designated as Compound 0, the residual proton temporarily associating with the distal pocket His109 residue.	Ferric enterobactin ion	136-142	lactoperoxidase	Homo sapiens	91-94
25965476-7	2015	In vitro antioxidant assay, GPA1, GPA2 and GPA3 could scavenge 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and hydroxyl radical, chelate ferrous ion and reduce ferric ion.	Ferric enterobactin ion	162-168	glycoprotein hormone subunit alpha 2	Homo sapiens	34-38
25475739-9	2014	Comparison between the bis-imidazole model complex and cyt c in ferrous and ferric oxidation states show quantitative differences that reflect differences in axial ligand covalency.	Ferric enterobactin ion	76-82	cytochrome c, somatic	Homo sapiens	55-60
25013070-4	2014	We present neutron structures of the ferric derivative of cytochrome c peroxidase and its ferryl intermediate; these allow direct visualization of protonation states.	Ferric enterobactin ion	37-43	cytochrome c, somatic	Homo sapiens	58-70
25372675-1	2014	Sperm whale myoglobin (Mb) functions as an oxygen-storage protein, but in the ferric state it possesses a weak peroxidase activity which enables it to carry out H2O2-dependent dehalogenation reactions.	Ferric enterobactin ion	78-84	myoglobin	Physeter catodon	12-21
25007760-2	2014	4-Arylquinoline 2-carboxylates 1o and 1q displayed significant antioxidant activity as indicated by their Fe-reducing power in the ferric reducing ability of plasma (FRAP) assay.	Ferric enterobactin ion	131-137	mechanistic target of rapamycin kinase	Homo sapiens	166-170
24991925-7	2014	Apo-transferrin (Tf), the primary carrier of soluble iron in the plasma, binds ferric ion to form mono-ferric and di-ferric transferrin.	Ferric enterobactin ion	79-85	transferrin	Homo sapiens	4-15
24991925-7	2014	Apo-transferrin (Tf), the primary carrier of soluble iron in the plasma, binds ferric ion to form mono-ferric and di-ferric transferrin.	Ferric enterobactin ion	79-85	transferrin	Homo sapiens	124-135
24690308-1	2014	The previously published method allowing the separation of non-ferric (iron-free) and ferric (iron-saturated) forms of human serum transferrin via capillary electrophoresis has been further developed.	Ferric enterobactin ion	63-69	transferrin	Homo sapiens	131-142
24632414-3	2014	In this study, we measured cyanide binding to the ferric state of the wild-type (WT) Cgb, and found that the binding consisted of multiple steps.	Ferric enterobactin ion	50-56	cytoglobin	Homo sapiens	85-88
24690308-1	2014	The previously published method allowing the separation of non-ferric (iron-free) and ferric (iron-saturated) forms of human serum transferrin via capillary electrophoresis has been further developed.	Ferric enterobactin ion	86-92	transferrin	Homo sapiens	131-142
24690308-3	2014	As a result, two previously unobserved monoferric forms of protein have been separated and identified, moreover, the loss of ferric ions from transferrin during electrophoretic separation has been considerably reduced by methanol, and the method selectivity has been yet increased resulting in a total separation of proteins exerting only subtle or none difference in mass-to-charge ratio.	Ferric enterobactin ion	43-49	transferrin	Homo sapiens	142-153
24690308-4	2014	The new method has allowed us to monitor the gradual iron saturation of transferrin by mixing the iron-free form of protein with the buffers with different concentrations of ferric ions.	Ferric enterobactin ion	174-180	transferrin	Homo sapiens	72-83
24446191-13	2014	Ferric reducing/antioxidant power (FRAP) value was decreased in the Vit C and Cr groups by transport.	Ferric enterobactin ion	0-6	vitrin	Gallus gallus	68-71
23811155-3	2013	In the new assay, LOX-derived lipid hydroperoxides oxidize the ferrous ion (Fe2+) to the ferric ion (Fe3+), the latter of which binds with thiocyanate (SCN-) to generate a red ferrithiocyanate (FTC) complex.	Ferric enterobactin ion	89-95	lysyl oxidase	Homo sapiens	18-21
24249253-5	2014	The ferric-reducing antioxidant power (FRAP assay) was 0.046 mumol/L trolox equivalent/mug/mL of extract.	Ferric enterobactin ion	4-10	mechanistic target of rapamycin kinase	Mus musculus	39-43
23981688-1	2014	BACKGROUND: Duodenal cytochrome b (Dcytb) is a mammalian plasma ferric reductase enzyme that catalyses the reduction of ferric to ferrous ion in the process of iron absorption.	Ferric enterobactin ion	64-70	cytochrome b reductase 1	Homo sapiens	12-33
23981688-1	2014	BACKGROUND: Duodenal cytochrome b (Dcytb) is a mammalian plasma ferric reductase enzyme that catalyses the reduction of ferric to ferrous ion in the process of iron absorption.	Ferric enterobactin ion	64-70	cytochrome b reductase 1	Homo sapiens	35-40
24881668-7	2014	Superoxide-treated hNgb in the ferric form was readily converted to the oxygenated ferrous form, and the result suggested that ferric hNgb could scavenge superoxide by change of an oxidation state in a heme iron.	Ferric enterobactin ion	31-37	neuroglobin	Homo sapiens	19-23
24881668-7	2014	Superoxide-treated hNgb in the ferric form was readily converted to the oxygenated ferrous form, and the result suggested that ferric hNgb could scavenge superoxide by change of an oxidation state in a heme iron.	Ferric enterobactin ion	31-37	neuroglobin	Homo sapiens	134-138
24211270-1	2014	Heme oxygenase (HO)-1 is an oxidative stress-response enzyme which catalyzes the degradation of heme into bilirubin, ferric ion, and carbon monoxide (CO).	Ferric enterobactin ion	117-123	heme oxygenase 1	Homo sapiens	0-21
25189388-3	2014	Unlike the native protein, cytochrome c within the complex binds ligands rapidly; in particular, NO can coordinate to either the ferric or ferrous iron of the heme.	Ferric enterobactin ion	129-135	cytochrome c, somatic	Homo sapiens	27-39
24473150-6	2014	However, aluminum, cupric, ferric and calcium ions were able to inhibit AChE via noncompetitive mechanism of inhibition.	Ferric enterobactin ion	27-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-76
25146186-1	2014	The interaction of both ferric (Fe3+) and cupric (Cu2+) ions with human serum albumin (HSA) was assayed at a temperature of 27 C in aqueous solution using isothermal titration calorimetry.	Ferric enterobactin ion	24-30	albumin	Homo sapiens	72-85
23584744-5	2013	PGP- and EGP-fortified breads diminished the negative impact of high-cholesterol/cholic acid diet, lowering total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), lipid peroxidation, glucose and leptin levels, preventing visceral fat accumulation and increasing high-density lipoprotein cholesterol and plasma ferric-reducing antioxidant power levels.	Ferric enterobactin ion	324-330	phosphoglycolate phosphatase	Rattus norvegicus	0-3
24038606-1	2013	Spin doctor: A mononuclear ferric complex [Fe(H-5-Br-thsa)(5-Br-thsa)] H2O (1) (H2-5-Br-thsa = 5-bromo-2-hydroxybenzylidene)hydrazinecarbothioamide) was synthesized and its magnetic properties and structure were investigated by DFT calculations.	Ferric enterobactin ion	27-33	spindlin 1	Homo sapiens	0-4
24046423-6	2013	This result indicated that the regulation of Hsp-70 gene expression in normal chickens, as estimated by oxidative stress indices [TBA reacting substances, ferric reducing/antioxidant power, and ceruloplasmin oxidase activity] levels, is tissue-specific.	Ferric enterobactin ion	155-161	heat shock protein family A (Hsp70) member 2	Gallus gallus	45-51
22882431-8	2013	THP-1 cell activation was inhibited by exposures to both plasma and a ferric compound; the effect of plasma on macrophage activation was not reversed by the iron chelator desferroxamine.	Ferric enterobactin ion	70-76	GLI family zinc finger 2	Homo sapiens	0-5
23597830-2	2013	The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields after excitotoxicity induced by the glutamate analog kainate (KA), but in order for iron to be transported by DMT1, it must be converted from the ferric to the ferrous form.	Ferric enterobactin ion	280-286	RoBo-1	Rattus norvegicus	28-56
23597830-2	2013	The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields after excitotoxicity induced by the glutamate analog kainate (KA), but in order for iron to be transported by DMT1, it must be converted from the ferric to the ferrous form.	Ferric enterobactin ion	280-286	RoBo-1	Rattus norvegicus	58-62
23507749-3	2013	A very good correlation of 0.807 was observed between the ferric reducing ability of plasma (FRAP) and total antioxidant status (TAS) assay and also a fair correlation of 0.501 between the biological antioxidant potential (BAP) and TAS assay.	Ferric enterobactin ion	58-64	mechanistic target of rapamycin kinase	Homo sapiens	93-97
22570238-4	2012	In this study, we found that ferric ion promoted Receptor Activator of Nuclear Factor kappa B Ligand (RANKL)-induced osteoclast (OC) formation in both RAW264.7 cells and bone marrow-derived macrophages (BMMs), and this effect was accompanied by elevated levels of reactive oxygen species (ROS) and oxidative stress.	Ferric enterobactin ion	29-35	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	49-100
23201463-2	2013	MetHb is produced in the RBC by irreversible NO-induced oxidation of the oxygen carrying ferrous ion (Fe(2+)) present in the heme group of the hemoglobin (Hb) molecule to its non-oxygen binding ferric state (Fe(3+)).	Ferric enterobactin ion	194-200	hemoglobin subunit gamma 2	Homo sapiens	0-5
23170793-4	2013	We have recently shown that trivalent iron (ferric ions) generates hydroxyl radicals, which subsequently convert FBG into abnormal fibrin clots in the form of DMDs.	Ferric enterobactin ion	44-50	fibrinogen beta chain	Homo sapiens	113-116
23337054-3	2013	Malondialdehyde (MDA) is an oxidative stress marker, and ferric reducing ability of plasma (FRAP) is an anti-oxidant capacity marker.	Ferric enterobactin ion	57-63	mechanistic target of rapamycin kinase	Homo sapiens	92-96
23132248-2	2012	beta-Galactosidase, encoded by lacZ, is usually detected using X-gal in combination with ferric and ferrous ions.	Ferric enterobactin ion	89-95	galactosidase, beta 1	Mus musculus	0-18
24135101-6	2013	Solution pH below 3.0 and stirring speed of 700 rev min(-1) could ensure a sufficiently high oxidation rate for Na(2)SO(3) with ferric ion higher than 0.469 mM.	Ferric enterobactin ion	128-134	CD59 molecule (CD59 blood group)	Homo sapiens	52-58
22570238-4	2012	In this study, we found that ferric ion promoted Receptor Activator of Nuclear Factor kappa B Ligand (RANKL)-induced osteoclast (OC) formation in both RAW264.7 cells and bone marrow-derived macrophages (BMMs), and this effect was accompanied by elevated levels of reactive oxygen species (ROS) and oxidative stress.	Ferric enterobactin ion	29-35	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	102-107
22389496-1	2012	Bacteria use tight-binding, ferric-specific chelators called siderophores to acquire iron from the environment and from the host during infection; animals use proteins such as transferrin and ferritin to transport and store iron.	Ferric enterobactin ion	28-34	transferrin	Homo sapiens	176-187
22957700-11	2012	Magnetic circular dichroism, resonance Raman, and electron paramagnetic resonance spectroscopic data on the ferric, ferrous, and ferrous-CO complexes of GAPDH showed that the heme is bis-ligated with His as the proximal ligand.	Ferric enterobactin ion	108-114	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	153-158
22836558-8	2012	Iron homeostasis is mainly regulated by transferrin, which transports ferric ions to other cells.	Ferric enterobactin ion	70-76	transferrin	Homo sapiens	40-51
22913825-3	2012	The key enzyme is 5-lipoxygenase, a dioxygenase containing a nonheme-bound ferric central ion, which in the catalytic complex with 5-lipoxygenase activating protein forms 5-hydroperoxyeicosatetraenoic acid.	Ferric enterobactin ion	75-81	arachidonate 5-lipoxygenase	Homo sapiens	18-32
22913825-3	2012	The key enzyme is 5-lipoxygenase, a dioxygenase containing a nonheme-bound ferric central ion, which in the catalytic complex with 5-lipoxygenase activating protein forms 5-hydroperoxyeicosatetraenoic acid.	Ferric enterobactin ion	75-81	arachidonate 5-lipoxygenase	Homo sapiens	131-145
22294389-4	2012	CDH induces PB formation via both reduction of ferricyanide to ferrocyanide reacting with an excess of Fe3+ (pathway 1) and reduction of ferric ions to Fe2+ reacting with the excess of ferricyanide (pathway 2).	Ferric enterobactin ion	47-53	choline dehydrogenase	Homo sapiens	0-3
22446753-2	2012	It was found that ferric ion (Fe(3+)) could selectively quench the fluorescence of 2PC-PPH, whereas many other metal ions, such as Mn(2+), Zn(2+), Cu(2+), K(+), Al(3+), Ca(2+), Ni(2+), Co(2+), Cr(3+) and Fe(2+), could not quench its fluorescence.	Ferric enterobactin ion	18-24	enolase 1	Homo sapiens	87-90
22146473-6	2012	In contrast to the previously known plutonium-binding proteins transferrin and ferritin, which bind ferric ions, most identified proteins in our experiment are known to bind calcium, magnesium, or divalent transition metal ions.	Ferric enterobactin ion	100-106	transferrin	Rattus norvegicus	63-74
22101012-1	2012	Transferrin receptor mediates internalization of transferrin with bound ferric ions through the clathrin-dependent pathway.	Ferric enterobactin ion	72-78	transferrin receptor	Homo sapiens	0-20
22101012-1	2012	Transferrin receptor mediates internalization of transferrin with bound ferric ions through the clathrin-dependent pathway.	Ferric enterobactin ion	72-78	transferrin	Homo sapiens	49-60
22308374-0	2012	Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.	Ferric enterobactin ion	0-6	DGCR8 microprocessor complex subunit	Homo sapiens	56-61
22172990-1	2012	The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated gastrins in vitro and in vivo.	Ferric enterobactin ion	38-44	gastrin	Mus musculus	20-27
21653899-3	2011	Expression of mouse Zip14 in RNA-injected oocytes stimulated the uptake of (55)Fe in the presence of l-ascorbate but not nitrilotriacetic acid, indicating that Zip14 is an iron transporter specific for ferrous ion (Fe(2+)) over ferric ion (Fe(3+)).	Ferric enterobactin ion	228-234	solute carrier family 39 (zinc transporter), member 14	Mus musculus	20-25
23505335-0	2011	Impact of Proximal and Distal Pocket Site-Directed Mutations on the Ferric/Ferrous Heme Redox Potential of Yeast Cytochrome-c-Peroxidase.	Ferric enterobactin ion	68-74	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	113-136
21978190-2	2011	The high-frequency RR (1300-1700 cm(-1)) indicates that the heme group is in the ferric, six-coordinate, low-spin state for both resting and ligand-bound hPGIS/zPGIS.	Ferric enterobactin ion	81-87	prostaglandin I2 synthase	Homo sapiens	154-159
21653899-3	2011	Expression of mouse Zip14 in RNA-injected oocytes stimulated the uptake of (55)Fe in the presence of l-ascorbate but not nitrilotriacetic acid, indicating that Zip14 is an iron transporter specific for ferrous ion (Fe(2+)) over ferric ion (Fe(3+)).	Ferric enterobactin ion	228-234	solute carrier family 39 (zinc transporter), member 14	Mus musculus	160-165
21554740-10	2011	The most specific and linear response was observed for pyoverdin immobilized in sol-gel C. In contrast, a solution of pyoverdin (3.0 muM) exposed to iron (II or III) for 10 minutes showed an increase in fluorescence (101 - 114%) at low ferrous concentrations (0.45 - 2.18 muM) while exposure to all ferric ion concentrations (0.45 - 3.03 muM) caused quenching.	Ferric enterobactin ion	299-305	latexin	Homo sapiens	133-136
21875066-2	2011	The presence of a heme cofactor in CBS is enigmatic, and its conversion from the ferric- to ferrous-CO state inhibits enzyme activity.	Ferric enterobactin ion	81-87	cystathionine beta-synthase	Homo sapiens	35-38
21652729-2	2011	We have previously demonstrated that ferric ions bind to gastrins, that the gastrin-ferric ion complex interacts with the iron transport protein transferrin in vitro, and that circulating gastrin concentrations positively correlate with transferrin saturation in vivo.	Ferric enterobactin ion	37-43	gastrin	Mus musculus	57-64
21652729-2	2011	We have previously demonstrated that ferric ions bind to gastrins, that the gastrin-ferric ion complex interacts with the iron transport protein transferrin in vitro, and that circulating gastrin concentrations positively correlate with transferrin saturation in vivo.	Ferric enterobactin ion	37-43	gastrin	Mus musculus	76-83
21652729-2	2011	We have previously demonstrated that ferric ions bind to gastrins, that the gastrin-ferric ion complex interacts with the iron transport protein transferrin in vitro, and that circulating gastrin concentrations positively correlate with transferrin saturation in vivo.	Ferric enterobactin ion	84-90	transferrin	Mus musculus	145-156
21652729-2	2011	We have previously demonstrated that ferric ions bind to gastrins, that the gastrin-ferric ion complex interacts with the iron transport protein transferrin in vitro, and that circulating gastrin concentrations positively correlate with transferrin saturation in vivo.	Ferric enterobactin ion	84-90	gastrin	Mus musculus	76-83
21652729-2	2011	We have previously demonstrated that ferric ions bind to gastrins, that the gastrin-ferric ion complex interacts with the iron transport protein transferrin in vitro, and that circulating gastrin concentrations positively correlate with transferrin saturation in vivo.	Ferric enterobactin ion	84-90	transferrin	Mus musculus	237-248
21536298-2	2011	The magnetic carbonaceous material with the maximum magnetic flux density on every axis (ESS-1) was obtained from the ferric-loaded resin by carbonization at 700 C, followed by activation with the oyster shell at 900 C, and magnetization.	Ferric enterobactin ion	118-124	transforming growth factor beta receptor 1	Homo sapiens	89-94
21376789-1	2011	Transferrin is a blood-plasma glycoprotein, which is responsible for ferric-ion delivery and which functions as the most important ferric pool in the body.	Ferric enterobactin ion	69-75	transferrin	Homo sapiens	0-11
21376789-1	2011	Transferrin is a blood-plasma glycoprotein, which is responsible for ferric-ion delivery and which functions as the most important ferric pool in the body.	Ferric enterobactin ion	131-137	transferrin	Homo sapiens	0-11
21376789-6	2011	Furthermore, it is shown that the preparation of these complexes from holo-transferrin leads to an irreversible loss of the ferric ions from the protein.	Ferric enterobactin ion	124-130	transferrin	Homo sapiens	75-86
21071493-1	2011	The ferric uptake regulator Fur has been reported to repress the expression of rmpA, a regulatory gene for the mucoid phenotype, leading to decreased capsular polysaccharide (CPS) biosynthesis in Klebsiella pneumoniae CG43.	Ferric enterobactin ion	4-10	regulator of mucoid phenotype	Klebsiella pneumoniae CG43	79-83
21517759-4	2011	The active IDO conformer exists only in the presence of reducing cofactors (such as cytochrome b(5)), requiring the single electron reduction of ferric-to-ferrous iron (Fe(3+) Fe(2+)), which facilitates binding of L-Trp and O(2) to the enzyme active site.	Ferric enterobactin ion	145-151	indoleamine 2,3-dioxygenase 1	Homo sapiens	11-14
22191012-6	2011	Also ferric-reducing ability of plasma (FRAP) increased significantly (interaction P = 0.024) after supplementation.	Ferric enterobactin ion	5-11	mechanistic target of rapamycin kinase	Homo sapiens	40-44
21195058-6	2011	In contrast, in the presence of ferric ions the rate of cleavage of both progastrin(55-80) and phosphoSer(75)progastrin(55-80) by prohormone convertase 1 was significantly reduced.	Ferric enterobactin ion	32-38	proprotein convertase subtilisin/kexin type 1	Homo sapiens	130-153
21150830-3	2010	The 60% ethanol extract (P-60) showed strong antioxidant activity based on the results of 2,2"-azino-di(3-ethylbenzthiazoline-6-sulfonic acid (ABTS +), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assay methods.	Ferric enterobactin ion	193-199	plasma protein 1	Mus musculus	25-29
21119927-2	2010	In this method, ferric ions are immobilized in the second-dimensional polyacrylamide gel to extract the phosphoprotein beta-casein from a mixture containing proteins with a broad range of pI and MW.	Ferric enterobactin ion	16-22	casein beta	Homo sapiens	119-130
23934922-8	2011	CONCLUSIONS/SIGNIFICANCE: Our data thus indicate that oxidative stress affects alpha-synuclein aggregation via oxidation of iron to the ferric state.	Ferric enterobactin ion	136-142	synuclein alpha	Homo sapiens	79-94
21966113-4	2010	A significant (P < 0.001) positive correlation (r = 0.8979) is observed between GST activity and total plasma antioxidant potential measured as ferric reducing ability of the plasma (FRAP).	Ferric enterobactin ion	147-153	mechanistic target of rapamycin kinase	Homo sapiens	186-190
20958043-4	2010	However, in treatment media with higher ionic strengths, ferric ion was released from the LF molecule into the aqueous phase.	Ferric enterobactin ion	57-63	lactotransferrin	Bos taurus	90-92
20608730-9	2010	The results also indicated that reduction of ferric to ferrous iron drives variations in ESP activity during early plant development.	Ferric enterobactin ion	45-51	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	89-92
19859668-1	2010	Human transferrin (Tf) very tightly binds two ferric ions to deliver iron to cells.	Ferric enterobactin ion	46-52	transferrin	Homo sapiens	6-17
19859668-1	2010	Human transferrin (Tf) very tightly binds two ferric ions to deliver iron to cells.	Ferric enterobactin ion	46-52	transferrin	Homo sapiens	19-21
21222379-7	2010	RESULTS: Both ferric (Fe3+) and ferrous (Fe2+) ions significantly decreased the BChE activity in all tested concentrations.	Ferric enterobactin ion	14-20	butyrylcholinesterase	Homo sapiens	80-84
20568729-4	2010	The data are consistent with cryogenic generation and trapping, at 100 K, of a ferrous d(6) Mb(II)(ONO)* complex by photoreduction of the ferric precursor crystals using high-intensity X-ray radiation.	Ferric enterobactin ion	138-144	myoglobin	Homo sapiens	92-94
21305139-4	2009	The ferric ion ligands have been identified as glutamates 7, 8 and 9 in the 18 amino acid peptide glycine-extended gastrin.	Ferric enterobactin ion	4-10	gastrin	Homo sapiens	115-122
20395538-2	2010	Gastrins bind two ferric ions selectively and with high affinity, and the biological activity of glycine-extended gastrin (Ggly) in vitro is dependent on the presence of ferric ions.	Ferric enterobactin ion	18-24	gastrin	Mus musculus	114-121
20395538-2	2010	Gastrins bind two ferric ions selectively and with high affinity, and the biological activity of glycine-extended gastrin (Ggly) in vitro is dependent on the presence of ferric ions.	Ferric enterobactin ion	170-176	gastrin	Mus musculus	114-121
20155941-4	2010	Normal coordinate structural decomposition (NSD) of the ferric CBS crystal structure predicts the enhancement of normal modes with significant heme "doming", "ruffling", and "saddling" content, and they are observed in the coherence spectra near approximately 40, approximately 60, and approximately 90 cm(-1).	Ferric enterobactin ion	56-62	cystathionine beta-synthase	Homo sapiens	63-66
20155941-6	2010	For ferric CBS, we observe a new mode near approximately 25 cm(-1), possibly involving the response of the protein, which exhibits a phase jump of approximately pi for excitation on the blue and red side of the Soret band maximum.	Ferric enterobactin ion	4-10	cystathionine beta-synthase	Homo sapiens	11-14
19664057-3	2009	Several lines of evidence, including the facts that transferrin binds gastrin, that gastrins bind ferric ions, and that the level of expression of gastrins positively correlates with transferrin saturation, suggest the possible involvement of the transferrin-gastrin interaction in iron homeostasis.	Ferric enterobactin ion	98-104	gastrin	Homo sapiens	84-91
19664057-6	2009	The fact that no interaction was observed in the presence of the chelator EDTA suggested that the gastrin-ferric ion complex was the interacting species.	Ferric enterobactin ion	106-112	gastrin	Homo sapiens	98-105
19664057-7	2009	Moreover, removal of ferric ions with EDTA reduced the stability of the complex between apo-transferrin and gastrins, and no interaction was observed between Gamide or Ggly and diferric transferrin.	Ferric enterobactin ion	21-27	transferrin	Homo sapiens	92-103
20395538-9	2010	These observations are consistent with the hypothesis that the biological activity of progastrin and Ggly in vivo is dependent on the presence of ferric ions and further suggest that chelating agents may block the stimulatory effects of gastrin precursors in the development of colorectal carcinoma.	Ferric enterobactin ion	146-152	gastrin	Mus musculus	89-96
20527030-8	2010	H(2)O binding to metmyoglobin (17,585 Da), where the heme iron is in the ferric oxidation state, is observed in ESI-MS. CO binding to Mb (17,595 Da), on the other hand, can be only observed after the heme iron is reduced to the ferrous form.	Ferric enterobactin ion	73-79	myoglobin	Homo sapiens	134-136
20199369-9	2010	Direct correlations were found between hepatocyte growth factor levels and ferric reducing activity of plasma as well as hepatocyte growth factor and creatinine or uric acid.	Ferric enterobactin ion	75-81	hepatocyte growth factor	Homo sapiens	39-63
19731896-4	2010	FeSINC nanoparticles were prepared by coprecipitation of both ferric and ferrous salts on the bovine insulin loaded silica nanoparticle.	Ferric enterobactin ion	62-68	insulin	Bos taurus	101-108
19032755-3	2008	METHODS: We assessed the resting and n-formyl-methionyl-leucyl-phenylalanine (fMLP)- induced whole blood chemiluminescence (as a measure of oxidant production by polymorphonuclear leukocytes and monocytes), ferric reducing ability of plasma (FRAP) and H2O2 generation in the whole blood of 27 untreated OSAS patients, 22 subjects after a night of CPAP therapy and 11 controls without OSAS.	Ferric enterobactin ion	207-213	formyl peptide receptor 1	Homo sapiens	78-82
19617683-0	2009	Polymorphism in the spin-crossover ferric complexes [(TPA)Fe(III)(TCC)]PF6.	Ferric enterobactin ion	35-41	sperm associated antigen 17	Homo sapiens	71-74
19218188-3	2009	In the present study, we measured the conformational changes in the haem pocket of recombinant human TDO (rhTDO) in ferric form that are induced by l-Trp binding using both resonance Raman and optical absorption spectroscopies.	Ferric enterobactin ion	116-122	tryptophan 2,3-dioxygenase	Homo sapiens	101-104
18778686-7	2008	On the contrary, the Gm and rHO-1 reactions with hydrogen peroxide both provided ferric low-spin intermediates though their yields were different.	Ferric enterobactin ion	81-87	heme oxygenase 1	Rattus norvegicus	28-33
19798993-1	2009	In the present work, the iron oxyhydroxides were prepared by hydrolysis and neutralization of ferric ion from FeCl3, Fe(NO3)3 and Fe2 (SO4)3 salts, under the conditions of various pH values and aging for about 6 days at 60 degrees C. These iron minerals were identified and characterized using X-ray diffraction (XRD), infrared spectroscopy (IR) and scanning electron microscopy (SEM).	Ferric enterobactin ion	94-100	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
19798993-3	2009	Results showed that ferrihydrite formed in the ferric solutions containing Cl-, NO3- and SO4(2-) at pH values of 8 and 10.	Ferric enterobactin ion	47-53	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
17990009-3	2008	Rates of iron removal from transferrin were determined spectrophotometrically for the ten ligands, which all efficiently acquire ferric ion from diferric transferrin with a hyperbolic dependence on ligand concentration (saturation kinetics).	Ferric enterobactin ion	129-135	transferrin	Homo sapiens	27-38
18241201-1	2008	BVR-B (biliverdin-IXbeta reductase) also known as FR (flavin reductase) is a promiscuous enzyme catalysing the pyridine-nucleotide-dependent reduction of a variety of flavins, biliverdins, PQQ (pyrroloquinoline quinone) and ferric ion.	Ferric enterobactin ion	224-230	biliverdin reductase B	Homo sapiens	0-5
18241201-1	2008	BVR-B (biliverdin-IXbeta reductase) also known as FR (flavin reductase) is a promiscuous enzyme catalysing the pyridine-nucleotide-dependent reduction of a variety of flavins, biliverdins, PQQ (pyrroloquinoline quinone) and ferric ion.	Ferric enterobactin ion	224-230	biliverdin reductase B	Homo sapiens	7-34
18717590-11	2008	Models are proposed in which the accumulation of ferric nanoparticles is caused either by the absence of a ligand that prevents such precipitation in wild-type mitochondria or by a more oxidizing environment within the mitochondria of Yah1p-depleted cells exposed to O 2.	Ferric enterobactin ion	49-55	adrenodoxin	Saccharomyces cerevisiae S288C	235-240
18447830-9	2008	EPR spectroscopy identified the ferric state of the bound metal, and indicated that the iron-hepcidin complex shares some similarities with the rubredoxin iron-sulfur complex, suggesting the presence of Fe(3+) in a tetrahedral sulfur co-ordination.	Ferric enterobactin ion	32-38	hepcidin antimicrobial peptide	Homo sapiens	93-101
18359283-14	2008	Our results, and a structure model based on the crystal structures of the ferrous dioxygen complexes of P450(cam) and its T252A mutant, suggest that Asn252 can stabilize the ferric hydroperoxy intermediate, preventing premature release of H(2)O(2) and enabling addition of the second proton to the distal oxygen to generate the catalytic ferryl species.	Ferric enterobactin ion	174-180	calmodulin 3	Homo sapiens	104-113
17990009-3	2008	Rates of iron removal from transferrin were determined spectrophotometrically for the ten ligands, which all efficiently acquire ferric ion from diferric transferrin with a hyperbolic dependence on ligand concentration (saturation kinetics).	Ferric enterobactin ion	129-135	transferrin	Homo sapiens	154-165
18006263-5	2008	TF is well known as a ferric ion transfer protein, and hence formation of this protein might be changed by ferric ion.	Ferric enterobactin ion	22-28	transferrin	Homo sapiens	0-2
17889392-2	2007	In the present study, a bioinformatics analysis showed that PA2384 has a weak similarity to the N-terminus DNA-binding domain of Fur, the well-known ferric uptake regulator.	Ferric enterobactin ion	149-155	hypothetical protein	Pseudomonas aeruginosa PAO1	60-66
18254708-5	2008	Associations between the DPPH test and the ferric reducing ability of serum (FRAP) method, measuring total antioxidant potential, were evaluated in sera from 78 healthy non-smoking men.	Ferric enterobactin ion	43-49	mechanistic target of rapamycin kinase	Homo sapiens	77-81
17889392-2	2007	In the present study, a bioinformatics analysis showed that PA2384 has a weak similarity to the N-terminus DNA-binding domain of Fur, the well-known ferric uptake regulator.	Ferric enterobactin ion	149-155	ferric uptake regulation protein	Pseudomonas aeruginosa PAO1	129-132
18075106-1	2007	Zeolite matrix FAU is applied as an effective support that can be readily exchanged with ferric ions simply by wet ion exchange.	Ferric enterobactin ion	89-95	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	15-18
17938141-0	2007	Involvement of 101F6, a homologue of cytochrome b561, in the reduction of ferric ions.	Ferric enterobactin ion	74-80	cytochrome b-561	Mus musculus	37-52
17938141-9	2007	Finally, reduction of ferric ions as well as of azo-dye increased with 101F6- or SDR-2-expressing cells.	Ferric enterobactin ion	22-28	serine dehydratase regulator 2	Mus musculus	81-86
17938141-10	2007	Thus, both 101F6 and SDR-2 were localized in small vesicles of cells and played roles in the reduction of ferric ions.	Ferric enterobactin ion	106-112	serine dehydratase regulator 2	Mus musculus	21-26
18031064-5	2007	Second, in order to probe the role of heme in the biological functioning of Dap1p, we measured ferric and ferrous heme binding affinities for Dap1p and the mutant Dap1pY138F, as well as equilibrium midpoint reduction potentials of the Fe(III)/Fe(II) couples.	Ferric enterobactin ion	95-101	Dap1p	Saccharomyces cerevisiae S288C	76-81
18031064-5	2007	Second, in order to probe the role of heme in the biological functioning of Dap1p, we measured ferric and ferrous heme binding affinities for Dap1p and the mutant Dap1pY138F, as well as equilibrium midpoint reduction potentials of the Fe(III)/Fe(II) couples.	Ferric enterobactin ion	95-101	Dap1p	Saccharomyces cerevisiae S288C	142-147
17972915-5	2007	Here, we report that Erv1 forms a 1:1 complex with cytochrome c and a reduced Erv1 can transfer electrons directly to the ferric form of the cytochrome.	Ferric enterobactin ion	122-128	growth factor, augmenter of liver regeneration	Homo sapiens	21-25
17972915-5	2007	Here, we report that Erv1 forms a 1:1 complex with cytochrome c and a reduced Erv1 can transfer electrons directly to the ferric form of the cytochrome.	Ferric enterobactin ion	122-128	cytochrome c, somatic	Homo sapiens	51-63
17972915-5	2007	Here, we report that Erv1 forms a 1:1 complex with cytochrome c and a reduced Erv1 can transfer electrons directly to the ferric form of the cytochrome.	Ferric enterobactin ion	122-128	growth factor, augmenter of liver regeneration	Homo sapiens	78-82
17562327-0	2007	Ferricyanide-mediated oxidation of ferrous nitrosylated sperm whale myoglobin involves the formation of the ferric nitrosylated intermediate.	Ferric enterobactin ion	108-114	myoglobin	Physeter catodon	68-77
18323241-1	2007	The joint effect of Antoxid (AX), extract from Radix Scutellariae baicalensis, with vitamin C on ferric reducing human plasma ability (FRAP) was examined.	Ferric enterobactin ion	97-103	mechanistic target of rapamycin kinase	Homo sapiens	135-139
17209551-6	2007	In the absence of NO, EPO-Fe(III) primarily converted to compound I and, upon H2O2 exhaustion, it decayed rapidly to the ferric form.	Ferric enterobactin ion	121-127	eosinophil peroxidase	Homo sapiens	22-25
18062223-9	2007	Spectrophotometric analysis revealed that the ratio of A406 to A280 for the catalase was 0.97, indicating the presence of a ferric component.	Ferric enterobactin ion	124-130	Rru_A1356	Rhodospirillum rubrum ATCC 11170	76-84
17655520-1	2007	Methemoglobin, a form of hemoglobin that does not bind oxygen, is produced when iron in red blood cells is oxidized from the ferrous state to the ferric state.	Ferric enterobactin ion	146-152	hemoglobin subunit gamma 2	Homo sapiens	0-13
17511610-2	2007	Lactoferrin was identified by N-terminal amino acid sequence and by capability to capture ferric cations resulting in a complex with absorbance maximum at 460-470 nm.	Ferric enterobactin ion	90-96	lactotransferrin	Canis lupus familiaris	0-11
17042493-6	2006	This peculiar behavior is discussed with respect to the MPO-typical covalent heme to protein linkages as well as to the published structures of ferric MPO and its cyanide complex and the recently published structure of lactoperoxidase as well as the physiological role of MPO in bacterial killing.	Ferric enterobactin ion	144-150	myeloperoxidase	Homo sapiens	151-154
17202686-3	2007	And six compounds were also subjected to six tests to speculate their properties: (1) inhibition of NO production by cultured J774.1 (macrophage-like) cell line, (2) suppression of inducible NO synthase (iNOS) gene expression, (3) inhibition of NO production by murine peritoneal macrophages, (4) DPPH radical scavenging activity, (5) reduction of ferric ion and (6) antioxidant activity.	Ferric enterobactin ion	348-354	nitric oxide synthase 2, inducible	Mus musculus	204-208
16928691-5	2006	Thus, the first electron to reduce the ferric iron of heme complexed with rHO-1 must be transferred from FMN.	Ferric enterobactin ion	39-45	heme oxygenase 1	Rattus norvegicus	74-79
17042493-6	2006	This peculiar behavior is discussed with respect to the MPO-typical covalent heme to protein linkages as well as to the published structures of ferric MPO and its cyanide complex and the recently published structure of lactoperoxidase as well as the physiological role of MPO in bacterial killing.	Ferric enterobactin ion	144-150	myeloperoxidase	Homo sapiens	151-154
16979986-7	2006	We evaluated the antioxidant power ferric reducing ability of plasma (FRAP) assay.	Ferric enterobactin ion	35-41	mechanistic target of rapamycin kinase	Homo sapiens	70-74
16413820-17	2006	The ferric reducing ability of plasma (FRAP) method reveals that the plasma of infusion-treated mice has a significantly higher antioxidant capacity than plasma from controls (p<0.01).	Ferric enterobactin ion	4-10	mechanistic target of rapamycin kinase	Mus musculus	39-43
16714573-8	2006	iha expression was regulated by the ferric uptake regulator Fur and by iron availability, as shown by real-time reverse transcriptase PCR.	Ferric enterobactin ion	36-42	bifunctional enterobactin receptor/adhesin protein	Escherichia coli	0-3
16154530-1	2005	O2-dependent reactions of the ferric and ferrous forms of alpha-hydroxyheme complexed with water-soluble rat heme oxygenase-1 were examined by rapid-scan stopped-flow measurements.	Ferric enterobactin ion	30-36	heme oxygenase 1	Rattus norvegicus	109-125
16445290-3	2006	We analyzed the structural effects of l-arginine (Arg) and tetrahydrobiopterin (H(4)B) binding on several key complexes (ferric, ferrous, ferrous-CO, and ferric-NO) and characterized the bonding properties of the proximal cysteine ligand.	Ferric enterobactin ion	121-127	H4 clustered histone 4	Homo sapiens	80-85
16719370-6	2006	In its oxidized, or ferric state, CYP exists as an equilibrium mixture of high- and low-spin configurations, each with distinctive UV/Vis absorption peaks.	Ferric enterobactin ion	20-26	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	34-37
15852126-0	2005	Spin crossover of ferric complexes with catecholate derivatives.	Ferric enterobactin ion	18-24	spindlin 1	Homo sapiens	0-4
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Ferric enterobactin ion	233-239	neuroglobin	Homo sapiens	34-37
16285745-7	2005	Reaction of the reduced DcrA-N with molecular oxygen results in autoxidation to form a ferric state without forming any stable oxygen-bound form probably due to the extremely low redox potential of DcrA-N (-250 mV).	Ferric enterobactin ion	87-93	dcrA	Desulfovibrio vulgaris str. Hildenborough	24-28
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Ferric enterobactin ion	233-239	cytoglobin	Homo sapiens	0-10
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Ferric enterobactin ion	233-239	cytoglobin	Homo sapiens	12-15
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Ferric enterobactin ion	233-239	neuroglobin	Homo sapiens	21-32
16040738-5	2005	These experiments reveal that, in ferric SOLly GLB1, one of the histidine planes is rotated 20 degrees (+/-10 degrees ) away from a N(heme)-Fe-N(heme) axis.	Ferric enterobactin ion	34-40	non-symbiotic hemoglobin class 1	Solanum lycopersicum	47-51
15931225-3	2005	The structure of AHSP bound to ferrous alphaHb is thought to represent a transitional complex through which alphaHb is converted to a non-reactive, hexacoordinate ferric form.	Ferric enterobactin ion	163-169	alpha hemoglobin stabilizing protein	Homo sapiens	17-21
15723537-2	2005	We previously demonstrated that ferric human Ngb binds to the alpha-subunits of heterotrimeric G proteins (Galpha) and acts as a guanine nucleotide dissociation inhibitor (GDI) for Galpha.	Ferric enterobactin ion	32-38	neuroglobin	Homo sapiens	45-48
15705575-4	2005	Here, the binding of ferric ion (chelated with a 2-fold molar ratio of nitrilotriacetate) to mTf has been studied using isothermal titration calorimetry and differential scanning calorimetry.	Ferric enterobactin ion	21-27	melanotransferrin	Mus musculus	93-96
15723537-2	2005	We previously demonstrated that ferric human Ngb binds to the alpha-subunits of heterotrimeric G proteins (Galpha) and acts as a guanine nucleotide dissociation inhibitor (GDI) for Galpha.	Ferric enterobactin ion	32-38	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	107-113
15723537-2	2005	We previously demonstrated that ferric human Ngb binds to the alpha-subunits of heterotrimeric G proteins (Galpha) and acts as a guanine nucleotide dissociation inhibitor (GDI) for Galpha.	Ferric enterobactin ion	32-38	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	181-187
16119677-1	2005	PURPOSE: The comparison of nutrition of children with high level of physical activity in dependence on antioxidative efficiency expressed in Ferric Reducing Ability of Plasma--FRAP adapted for saliva.	Ferric enterobactin ion	141-147	mechanistic target of rapamycin kinase	Homo sapiens	176-180
15155457-10	2004	Ferric ion was reduced to ferrous ion and taken up by hepatocytes by a pathway shared with diferric transferrin.	Ferric enterobactin ion	0-6	transferrin	Mus musculus	100-111
15548892-3	2004	Co-incubation of the oxy form (HbFe(2+)) with hypoxic BAECs resulted in an increase in the expression of HIF-1alpha in a manner that corresponded linearly with the decay of HbFe(2+) and accumulation of the ferric form (HbFe(3+)).	Ferric enterobactin ion	206-212	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-115
15544339-5	2004	Instead, pH was found to control the equilibrium amount of ferric and ferrous heme present after reaction of CBS with one-electron reducing agents.	Ferric enterobactin ion	59-65	cystathionine beta-synthase	Homo sapiens	109-112
15325179-1	2004	In this study, the relative importance of the dual reaction pathways of CO2*- in the photo/ferrioxalate system, where it acts both as a reductant for reducing the ferric ion and as an agent for the formation of H(2)O(2), was investigated as a function of the concentrations of ferrioxalate and oxygen.	Ferric enterobactin ion	163-169	complement C2	Homo sapiens	72-75
15801461-9	2004	The redox state of the electrostatically bound cytochrome c monolayers could be electrochemically switched between ferric and ferrous forms.	Ferric enterobactin ion	115-121	cytochrome c, somatic	Homo sapiens	47-59
15260345-8	2004	The reaction mechanism for pyrite oxidation at pH 2 is first order for pyrite leached by solutions containing only ferric, ferric together with silicate, and ferric combined with silicate and lipid.	Ferric enterobactin ion	115-121	polyhomeotic homolog 2	Homo sapiens	47-51
15260345-8	2004	The reaction mechanism for pyrite oxidation at pH 2 is first order for pyrite leached by solutions containing only ferric, ferric together with silicate, and ferric combined with silicate and lipid.	Ferric enterobactin ion	123-129	polyhomeotic homolog 2	Homo sapiens	47-51
15260345-8	2004	The reaction mechanism for pyrite oxidation at pH 2 is first order for pyrite leached by solutions containing only ferric, ferric together with silicate, and ferric combined with silicate and lipid.	Ferric enterobactin ion	123-129	polyhomeotic homolog 2	Homo sapiens	47-51
15165856-3	2004	Here, the X-ray crystal structure of wild type human Cgb in the ferric state at 2.4A resolution is reported.	Ferric enterobactin ion	64-70	cytoglobin	Homo sapiens	53-56
15130787-4	2004	In the absence of dioxygen, ferrous MPO decays to ferric MPO (0.04 s(-1) at pH 8 versus 1.4 s(-1) at pH 5).	Ferric enterobactin ion	50-56	myeloperoxidase	Homo sapiens	36-39
15130787-4	2004	In the absence of dioxygen, ferrous MPO decays to ferric MPO (0.04 s(-1) at pH 8 versus 1.4 s(-1) at pH 5).	Ferric enterobactin ion	50-56	myeloperoxidase	Homo sapiens	57-60
15130787-8	2004	The rate constant of dioxygen dissociation from compound III is much higher than conversion of compound III to ferric MPO (which is not affected by the oxygen concentration).	Ferric enterobactin ion	111-117	myeloperoxidase	Homo sapiens	118-121
15070359-2	2004	Using electron paramagnetic resonance (EPR), we show that formation of a disulfide bridge in ferric hNgb causes a considerable change in the heme pocket structure, whereas this is not so clear for ferric hCygb.	Ferric enterobactin ion	93-99	neuroglobin	Homo sapiens	100-104
15066989-5	2004	In contrast, in the NO-bound ferric complexes, the addition of l-Arg alone does not affect the structural properties of the Fe-N-O moiety, but H4B binding forces it to adopt a bent structure, which is further enhanced by the subsequent addition of l-Arg.	Ferric enterobactin ion	29-35	H4 clustered histone 4	Homo sapiens	143-146
15110862-1	2004	Social life is prone to invasion by microorganisms, and binding of ferric ions by transferrin is an efficient strategy to restrict their access to iron.	Ferric enterobactin ion	67-73	transferrin	Apis mellifera	82-93
15056890-4	2004	After transferrin-rich extract was isolated by batch type ion exchange chromatography, a soluble ferric complex of the transferrin extract was prepared by adding ferric salts to transferrin extract followed by dialysis, sterilization, and freeze drying.	Ferric enterobactin ion	97-103	transferrin	Rattus norvegicus	119-130
15056890-4	2004	After transferrin-rich extract was isolated by batch type ion exchange chromatography, a soluble ferric complex of the transferrin extract was prepared by adding ferric salts to transferrin extract followed by dialysis, sterilization, and freeze drying.	Ferric enterobactin ion	97-103	transferrin	Rattus norvegicus	119-130
12842469-0	2003	Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications.	Ferric enterobactin ion	26-32	heme oxygenase 1	Homo sapiens	97-113
14645216-3	2004	Wild-type neuroglobin has been shown to have six-coordinate heme in both ferric and ferrous states.	Ferric enterobactin ion	73-79	neuroglobin	Homo sapiens	10-21
14729300-0	2004	Synergistic anion-directed coordination of ferric and cupric ions to bovine serum transferrin--an inorganic perspective.	Ferric enterobactin ion	43-49	transferrin	Homo sapiens	82-93
14645044-1	2003	Human serum transferrin tightly binds ferric ions in the blood stream but is able to release them in cells by a process involving receptor-mediated endocytosis and decrease in pH.	Ferric enterobactin ion	38-44	transferrin	Homo sapiens	12-23
12743117-1	2003	Ceruloplasmin (Cp) is a ferroxidase that converts highly toxic ferrous iron to its non-toxic ferric form.	Ferric enterobactin ion	93-99	ceruloplasmin	Homo sapiens	0-13
12480932-5	2003	After sonication of the cells wild-type neuroglobin oxidizes rapidly to the hexacoordinated ferric form, whereas NO ligation initially protects the mutants from oxidation.	Ferric enterobactin ion	92-98	neuroglobin	Mus musculus	40-51
18494894-10	2003	This was minimized by the use of an agent, butylated hydroxytoluene (BHT), capable of liberating iron from transferrin via reduction of transferrin-bound ferric ions, allowing subsequent sequestration of Fe(II).	Ferric enterobactin ion	154-160	transferrin	Homo sapiens	107-118
18494894-10	2003	This was minimized by the use of an agent, butylated hydroxytoluene (BHT), capable of liberating iron from transferrin via reduction of transferrin-bound ferric ions, allowing subsequent sequestration of Fe(II).	Ferric enterobactin ion	154-160	transferrin	Homo sapiens	136-147
12700102-8	2003	However, unlike the other TonB-dependent receptors where vitamins or ferric-siderophores are wholly internalized, the bacterial transferrin receptor must remove iron from transferrin at the cell surface.	Ferric enterobactin ion	69-75	transferrin	Homo sapiens	128-139
12582819-1	2003	The sperm whale myoglobin mutant H64V, where the distal histidine is mutated to valine, is known to be five coordinated in the ferric state at room temperature and physiological pH.	Ferric enterobactin ion	127-133	myoglobin	Physeter catodon	16-25
12888278-1	2003	Both the binding and releasing of ferric ions in C-, and N-terminal binding sites of human serum transferrin are different.	Ferric enterobactin ion	34-40	transferrin	Homo sapiens	97-108
12601757-1	2003	Lactoferrin, a member of the transferrin family of approximately 80 kDa, consists of a single polypeptide chain folded in two symmetric, globular lobes (N- and C-lobes), each able to bind one ferric ion.	Ferric enterobactin ion	192-198	lactotransferrin	Bos taurus	0-11
12601757-1	2003	Lactoferrin, a member of the transferrin family of approximately 80 kDa, consists of a single polypeptide chain folded in two symmetric, globular lobes (N- and C-lobes), each able to bind one ferric ion.	Ferric enterobactin ion	192-198	serotransferrin	Bos taurus	29-40
12547225-1	2002	Dcytb has been identified as the mammalian transplasma ferric reductase that catalyzes the reduction of ferric to ferrous iron in the process of iron absorption.	Ferric enterobactin ion	55-61	cytochrome b reductase 1	Homo sapiens	0-5
12071697-4	2002	Increasing the initial pH of shake-flask culture medium from 6.0 to 7.0 or adding ferric ions to the medium (to 100 microM) resulted in significant improvements in expression of rPLF from P. pastoris.	Ferric enterobactin ion	82-88	periostin	Rattus norvegicus	178-182
12137512-6	2002	Following on recent reports, we demonstrate the persulfide form of IscU to be a dead-end complex that is incapable of forming holoprotein after addition of ferrous or ferric ion.	Ferric enterobactin ion	167-173	iron-sulfur cluster assembly enzyme	Homo sapiens	67-71
12473103-3	2002	Lanthanide cations are similar to ferric ions with regard to transferrin binding, suggesting transferrin-receptor mediated transport is possible; however, this has not yet been confirmed.	Ferric enterobactin ion	34-40	transferrin	Homo sapiens	61-72
12162745-5	2002	Nonlinear regression analysis of OPP"s inhibition of arachidonic acid dioxygenation indicated mixed inhibition toward the ferric form of 12-LOX with apparent K(I) values in the low micromolar range: 2.0 +/- 0.2 microM for the free enzyme and 4.5 +/- 0.7 microM for the substrate-bound form of the enzyme.	Ferric enterobactin ion	122-128	lysyl oxidase	Homo sapiens	140-143
11535048-0	2001	Selective, high-affinity binding of ferric ions by glycine-extended gastrin(17).	Ferric enterobactin ion	36-42	gastrin	Homo sapiens	68-75
12367579-6	2002	By a careful, layer by layer analysis of transgene expression along the crypt-villus axis, we were able to affirm that the ectopic expression of transgenic HFE in the differentiated villi enterocytes was responsible for ferric hyperabsorption, a phenomenon exacerbated in the absence of endogenous HFE expression, which we assessed by crossing the transgene onto an HFE(-/-) (knockout) background.	Ferric enterobactin ion	220-226	homeostatic iron regulator	Mus musculus	156-159
11999386-8	2002	In contrast, the assays TEAC II and III, DPPH, DMPD and FRAP analyse the ability to reduce the radical cation (TEAC II and III, DPPH, DMPD) or the ferric ion (FRAP).	Ferric enterobactin ion	147-153	mechanistic target of rapamycin kinase	Homo sapiens	56-60
11999386-8	2002	In contrast, the assays TEAC II and III, DPPH, DMPD and FRAP analyse the ability to reduce the radical cation (TEAC II and III, DPPH, DMPD) or the ferric ion (FRAP).	Ferric enterobactin ion	147-153	mechanistic target of rapamycin kinase	Homo sapiens	159-163
11535048-11	2001	The binding of ferric ions by glycine-extended gastrin(17) at low pH is consistent with a role for progastrin-derived peptides in iron uptake from the lumen of the gastrointestinal tract.	Ferric enterobactin ion	15-21	gastrin	Homo sapiens	47-54
11535048-2	2001	A role for the hormone gastrin in iron uptake as a chelator of ferric ions in the gastric lumen has been proposed previously [Baldwin, G. S. (1992) Med.	Ferric enterobactin ion	63-69	gastrin	Homo sapiens	23-30
11535048-5	2001	The maximum at 281 nm in the absorption spectrum of glycine-extended gastrin(17) at pH 4.0 increased (2.07 +/- 0.30)-fold in the presence of > or =2 equiv of ferric ions.	Ferric enterobactin ion	161-167	gastrin	Homo sapiens	69-76
11535048-6	2001	Titration of glycine-extended gastrin(17) with ferric ions under stoichiometric conditions indicated that the stoichiometry of binding was 2.00 +/- 0.28 mol of Fe(3+)/mol of peptide.	Ferric enterobactin ion	47-53	gastrin	Homo sapiens	30-37
11300822-1	2001	Myoglobin was reconstituted with the ferric complex of corrphycene, a novel porphyrin isomer with a rearranged tetrapyrrole array, to investigate the influence of porphyrin deformation on the equilibrium between high-spin (S = 5/2) and low-spin (S = 1/2) states in the azide derivative.	Ferric enterobactin ion	37-43	myoglobin	Homo sapiens	0-9
11500408-2	2001	The virulence of P. aeruginosa PAO1 is influenced by the iron- and oxygen-regulated gene encoding the alternative sigma factor PvdS, which is regulated through the ferric uptake regulator (Fur).	Ferric enterobactin ion	164-170	ferric uptake regulation protein	Pseudomonas aeruginosa PAO1	189-192
11367578-2	2001	The photon intensity was affected by the ferric state of Hb (methemoglobin > oxyhemoglobin), and was roughly correlated with the radical-scavenging potential of catechins.	Ferric enterobactin ion	41-47	hemoglobin subunit gamma 2	Homo sapiens	61-74
11457012-5	2001	These results indicate that the heme iron of myoglobin in the film is the ferric low-spin state, and the iron atom is pulled to the heme plane.	Ferric enterobactin ion	74-80	myoglobin	Homo sapiens	45-54
11473128-4	2001	The ferric (Fe(3+)) form of neuroglobin is also hexacoordinated with the protein ligand E7-His and does not exhibit pH dependence.	Ferric enterobactin ion	4-10	neuroglobin	Mus musculus	28-39
11226677-4	2001	Bcl-xL protein was also up-regulated during oxidative stress induced by exposure to hydrogen peroxide (3-100microM) or ferric ions (1-10microM).	Ferric enterobactin ion	119-125	BCL2 like 1	Homo sapiens	0-6
11148040-5	2001	In this study, we have characterized the heme cofactor of CBS in both the ferric and ferrous states using resonance Raman spectroscopy.	Ferric enterobactin ion	74-80	cystathionine beta-synthase	Homo sapiens	58-61
11123951-2	2000	Obtaining viable H. pylori mutants upon mutagenesis of the genes encoding NifU and NifS was unsuccessful even by growing the potential transformants under many different conditions including low O(2) atmosphere and supplementation with both ferric and ferrous iron.	Ferric enterobactin ion	241-247	iron-sulfur cluster assembly enzyme	Homo sapiens	74-78
11158346-9	2001	Cells bearing the AFT1(up) mutation accumulated large amounts of ferric siderophores.	Ferric enterobactin ion	65-71	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	18-22
10996833-2	2000	FMO is an intracellular ferrireductase which may be responsible for the obligatory reduction of ferric to ferrous iron so that reduced iron can be incorporated into heme by ferrochelatase.	Ferric enterobactin ion	96-102	ferrochelatase	Homo sapiens	173-187
11140262-9	2000	The marked difference in the kinetics of photoinactivation of the apo and holo forms, the light dose-independent effect of the sulfhydril group reagent, 2-mercaptoethanol and the partial protection brought by the ferric ion complexing agent desferrioxamine suggest that the photochemistry of the 4Fe-4S cluster of the holo form plays little, if any, role in the photoinactivation of the apo-IRP-1/IRE interaction.	Ferric enterobactin ion	213-219	aconitase 1	Homo sapiens	391-396
11068048-4	2000	At pH 7 and 15 degrees C, the rate constant of the reaction between 3-chloroperoxybenzoic acid and ferric MPO was similar to that with hydrogen peroxide (1.8x10(7) M(-1) s(-1) and 1.4x10(7) M(-1) s(-1), respectively).	Ferric enterobactin ion	99-105	myeloperoxidase	Homo sapiens	106-109
10920253-3	2000	Alkylamines (C >/= 5) induced changes in the spectrum of ferric P450(SPalpha) to one typical of a nitrogenous ligand-bound low-spin form of ferric P450, although their affinities were lower than those for other P450s, and a substrate, laurate, did not interfere with the binding in contrast with in the cases of other P450s.	Ferric enterobactin ion	60-66	CD5 molecule like	Homo sapiens	67-79
10922514-6	2000	However, we propose that regulation of the GAT-3 subtype transporter was chronically elevated (at least 30 days), represents an effect of epileptogenesis induced by ferric ion injected into the amygdaloid body.	Ferric enterobactin ion	165-171	solute carrier family 6 member 11	Rattus norvegicus	43-48
10844648-5	2000	Antibody production against FetA commonly occurs in infected patients, and we therefore hypothesize that phase variation reflects a balance between the advantages of being able to use a ferric siderophore as an iron source and evasion of the host immune response.	Ferric enterobactin ion	186-192	ATPase phospholipid transporting 8B5, pseudogene	Homo sapiens	28-32
10622706-1	1999	The O2*- -generating step of plant peroxidases during their catalytic cycle is represented by the decay of compound III (CoIII) into ferriperoxidase, which most likely involves the dissociation of a ferric-O2*- complex to yield the ferric form of the enzyme and O2*-.	Ferric enterobactin ion	199-205	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	107-119
10681518-5	2000	NO binds to both ferric (Fe(III), the catalytically active species) and ferrous (Fe(II)) forms of MPO, generating stable low-spin six-coordinate complexes, MPO-Fe(III).NO and MPO-Fe(II).NO, respectively.	Ferric enterobactin ion	17-23	myeloperoxidase	Homo sapiens	98-101
10681518-5	2000	NO binds to both ferric (Fe(III), the catalytically active species) and ferrous (Fe(II)) forms of MPO, generating stable low-spin six-coordinate complexes, MPO-Fe(III).NO and MPO-Fe(II).NO, respectively.	Ferric enterobactin ion	17-23	myeloperoxidase	Homo sapiens	156-159
10681518-5	2000	NO binds to both ferric (Fe(III), the catalytically active species) and ferrous (Fe(II)) forms of MPO, generating stable low-spin six-coordinate complexes, MPO-Fe(III).NO and MPO-Fe(II).NO, respectively.	Ferric enterobactin ion	17-23	myeloperoxidase	Homo sapiens	156-159
10601869-2	2000	Assignment of three heme methyl resonances of the isocyanide adduct of cytochrome P450 in the ferric low-spin state was recently performed using electron exchange in the presence of putidaredoxin [Mouro, C., Bondon, A., Jung, C., Hui Bon Hoa, G., De Certaines, J.D., Spencer, R.G.S.	Ferric enterobactin ion	94-100	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	71-86
10994872-1	2000	Myeloperoxidase is very susceptible to reducing radicals because the reduction potential of the ferric/ferrous redox couple is much higher compared with other peroxidases.	Ferric enterobactin ion	96-102	myeloperoxidase	Homo sapiens	0-15
10704209-1	2000	Previous work has demonstrated that the ferric form of soybean lipoxygenase-1 will catalyze an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce 9, 11-octadecadienoic acid and iodide ion.	Ferric enterobactin ion	40-46	linoleate 9S-lipoxygenase-4	Glycine max	63-75
10601869-0	2000	Assignment of heme methyl 1H-NMR resonances of high-spin and low-spin ferric complexes of cytochrome p450cam using one-dimensional and two-dimensional paramagnetic signals enhancement (PASE) magnetization transfer experiments.	Ferric enterobactin ion	70-76	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	90-105
10502679-7	1999	EPR spectra of cytochrome b(558) activated by either arachidonic acid or myristic acid, showed that a transient high-spin ferric species accounting for approximately 50% of the heme appeared in the presence of arachidonic acid, but not in the presence of myristic acid.	Ferric enterobactin ion	122-128	cytochrome b	Sus scrofa	15-27
10569637-5	1999	When subjected to acute oxidant stress by exposure to ferric/ascorbic acid or tert-butylhydroperoxide (tert-BHT), catalase activity showed a steeper decline compared with GSH-PX.	Ferric enterobactin ion	54-60	catalase	Homo sapiens	114-122
10521251-5	1999	The Fe(II)-substituted insulin hexamer is converted to the ferric analogue upon addition of phenol.	Ferric enterobactin ion	59-65	insulin	Homo sapiens	23-30
10388773-1	1999	Electronic absorption and resonance Raman (RR) spectra of the ferric form of barley grain peroxidase (BP 1) at various pH values, at both room temperature and 20 K, are reported, together with electron paramagnetic resonance spectra at 10 K. The ferrous forms and the ferric complex with fluoride have also been studied.	Ferric enterobactin ion	62-68	prx7	Hordeum vulgare	90-100
10192390-1	1999	Plasma iron circulates bound to transferrin (Trf), which solubilizes the ferric ion and attenuates its reactivity.	Ferric enterobactin ion	73-79	transferrin	Mus musculus	32-43
10381381-3	1999	Metalloporphyrins, including zinc-, cobalt-, and tin-protoporphyrin, ferric ion, and protoporphyrin also induced c-fos mRNA.	Ferric enterobactin ion	69-75	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118
10192390-1	1999	Plasma iron circulates bound to transferrin (Trf), which solubilizes the ferric ion and attenuates its reactivity.	Ferric enterobactin ion	73-79	transferrin	Mus musculus	45-48
9882647-13	1999	It was concluded that the observed EutF phenotypes were due to the partial loss of TonB function, which is proposed to result in reduced cobalamin and ferric siderophore transport in an aerobic environment; thus, the eutF locus does not exist.	Ferric enterobactin ion	151-157	transporter TonB	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	83-87
9779582-11	1998	However, in the ferric form, substitution of Trp-14 in W14F resulted in low stability at acid pH, as evident from lifetimes modifications at pH 4.8, while no modifications were produced by titrations of W7F to pH 4.5.	Ferric enterobactin ion	16-22	thioredoxin domain containing 17	Homo sapiens	45-51
9822635-3	1998	In low density lipoprotein (LDL), myoglobin induced a 30-fold increase in the formation of F2-isoprostanes by a mechanism involving redox cycling between ferric and ferryl forms of myoglobin.	Ferric enterobactin ion	154-160	myoglobin	Homo sapiens	34-43
10022330-9	1998	Transferrin capacity is saturated after the absorption of a toxic dose resulting in much of the circulating iron being hydrated ferric ion.	Ferric enterobactin ion	128-134	transferrin	Homo sapiens	0-11
11670788-1	1998	Application to High-Spin Ferric Complexes.	Ferric enterobactin ion	25-31	spindlin 1	Homo sapiens	20-24
11670788-8	1998	The problem of ZFS in high-spin ferric complexes is treated at some length, and contributions due to low-symmetry distortions, anisotropic covalency, charge-transfer states, and ligand spin-orbit coupling are discussed.	Ferric enterobactin ion	32-38	spindlin 1	Homo sapiens	27-31
9545294-10	1998	Inactivation of XylE by 4-methylcatechol resulted in oxidation of the active site iron to a high spin ferric state that was detectable by EPR.	Ferric enterobactin ion	102-108	catechol 2,3-dioxygenase	Pseudomonas putida	16-20
9760232-1	1998	Serum transferrin binds ferric ions in the bloodstream and transports them to cells, where they are released in a process involving receptor-mediated endocytosis.	Ferric enterobactin ion	24-30	transferrin	Homo sapiens	6-17
9531620-11	1998	The higher iron absorption capacity in the beta2m-/- mice may involve the initial step of ferric mucosal uptake and the subsequent step of mucosal transfer of iron to the plasma.	Ferric enterobactin ion	90-96	beta-2 microglobulin	Mus musculus	43-49
9478985-0	1998	Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts.	Ferric enterobactin ion	24-30	matrix metallopeptidase 1	Homo sapiens	117-141
9637000-2	1998	The modification caused a shift of the Soret band in the light absorption spectrum, from 430 nm to 418 nm in the case of myeloperoxidase (native ferric form), and from 412 nm to 406 nm in the case of lactoperoxidase (native ferric form).	Ferric enterobactin ion	145-151	myeloperoxidase	Homo sapiens	121-136
9637000-2	1998	The modification caused a shift of the Soret band in the light absorption spectrum, from 430 nm to 418 nm in the case of myeloperoxidase (native ferric form), and from 412 nm to 406 nm in the case of lactoperoxidase (native ferric form).	Ferric enterobactin ion	224-230	myeloperoxidase	Homo sapiens	121-136
9502734-6	1998	Consistent with preliminary histochemical analysis indicating that at least the transport of ferric ions is defective in Hdh mutants and in conjunction with the known localization of huntingtin in the membranes of vesicles associated with microtubules, we hypothesize that this protein is involved in the intracellular trafficking of nutrients in early embryos.	Ferric enterobactin ion	93-99	huntingtin	Mus musculus	121-124
9478985-0	1998	Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts.	Ferric enterobactin ion	24-30	matrix metallopeptidase 1	Homo sapiens	143-183
9478985-0	1998	Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts.	Ferric enterobactin ion	24-30	matrix metallopeptidase 3	Homo sapiens	189-202
9478985-0	1998	Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts.	Ferric enterobactin ion	24-30	matrix metallopeptidase 3	Homo sapiens	204-209
9182996-2	1997	More recently, NO was shown to interact also with a mammalian 15-lipoxygenase [Wiesner, R., Rathmann, J., Holzhutter, H. G., Stosser, R., Mader, K., Nolting, H. & Kuhn, H. (1996) Nitric oxide oxidises ferrous mammalian lipoxygenases to a pre-activated ferric species, FEBS Lett.	Ferric enterobactin ion	256-262	arachidonate 15-lipoxygenase	Homo sapiens	62-77
9407045-3	1997	Because the intermediate exhibits characteristic absorption spectrum of compound I and bears two electron oxidizing equivalents above the ferric state, we have assigned the species as compound I of myoglobin (Mb-I).	Ferric enterobactin ion	138-144	myoglobin	Physeter catodon	198-207
9407045-3	1997	Because the intermediate exhibits characteristic absorption spectrum of compound I and bears two electron oxidizing equivalents above the ferric state, we have assigned the species as compound I of myoglobin (Mb-I).	Ferric enterobactin ion	138-144	myoglobin	Physeter catodon	209-213
9434735-1	1997	Recombinant human theta class glutathione transferase T1-1 has been heterologously expressed in Escherichia coli and a simple purification method involving immobilized ferric ion affinity chromatography and Orange A dye chromatography is described.	Ferric enterobactin ion	168-174	glutathione S-transferase theta 1	Homo sapiens	30-58
9383187-4	1997	One of these proteins, TbpA, is homologous to the TonB-dependent family of outer membrane receptors that are required for high-affinity uptake of vitamin B12 and ferric siderophores.	Ferric enterobactin ion	162-168	transthyretin	Homo sapiens	23-27
9200812-1	1997	High-affinity iron uptake in Saccharomyces cerevisiae involves the extracytoplasmic reduction of ferric ions by FRE1 and FRE2 reductases.	Ferric enterobactin ion	97-103	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	112-116
9200812-1	1997	High-affinity iron uptake in Saccharomyces cerevisiae involves the extracytoplasmic reduction of ferric ions by FRE1 and FRE2 reductases.	Ferric enterobactin ion	97-103	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	121-125
9294820-3	1997	The influence of ferric ions, EDTA, and visible light on the oxidation of methionine and the covalent reducible and nonreducible dimerization in human Insulin-like Growth Factor I (hIGF-I) in aqueous (1 mM) phosphate buffer solution were studied.	Ferric enterobactin ion	17-23	insulin like growth factor 1	Homo sapiens	181-187
9294820-9	1997	The covalent dimerization of hIGF-I was correlated to visible light and ferric ions.	Ferric enterobactin ion	72-78	insulin like growth factor 1	Homo sapiens	29-35
9294820-12	1997	The oxidation of methionine 59 in hIGF-I is catalyzed by light and by ferric ions in combination with EDTA.	Ferric enterobactin ion	70-76	insulin like growth factor 1	Homo sapiens	34-40
9294820-13	1997	The covalent dimerization of hIGF-I is mainly affected by light and by ferric ions.	Ferric enterobactin ion	71-77	insulin like growth factor 1	Homo sapiens	29-35
9294820-16	1997	EDTA is necessary for ferric ions to be active in the oxidation of methionine in hIGF-I but not for the covalent dimerization.	Ferric enterobactin ion	22-28	insulin like growth factor 1	Homo sapiens	81-87
9210294-6	1997	Furthermore, experiments demonstrate that at acidic pH the inhibitory effect of ascorbate on the rate of Fe(3+)-transferrin formation is not primarily due to an interaction with ceruloplasmin, but to a reduction of enzymically generated ferric ions before they are bound to apotransferrin.	Ferric enterobactin ion	237-243	transferrin	Homo sapiens	112-123
9223614-6	1997	These results suggest that neutrophils inhibit the growth of C. albicans regardless of whether there is direct contact between them and Candida cells: neutrophil growth inhibition effects were augmented in the presence of a physiological concentration of lactoferrin, perhaps through some action of lactoferrin other than chelation of ferric ion.	Ferric enterobactin ion	335-341	lactotransferrin	Bos taurus	255-266
8917440-5	1996	The addition of dopamine or H2O2 oxidizes the ferrous iron of the native human TH to the ferric state.	Ferric enterobactin ion	89-95	tyrosine hydroxylase	Homo sapiens	79-81
9178558-4	1997	No effects of diethylenetriaminepentaacetic acid (DTPA) on the induction period (the period during the first phase) and the maximum oxygen consumption rate (MOCR) in the second phase indicate that free ferric ions liberated from myoglobin had no role in any phases during the lipid peroxidation.	Ferric enterobactin ion	202-208	myoglobin	Homo sapiens	229-238
8937423-3	1996	Spectral studies revealed that LPO-compound II oxidises indomethacin through one-electron transfer and is reduced to the native ferric state as shown by its spectral shift from 430 nm to 412 nm through an isosbestic point at 421 nm.	Ferric enterobactin ion	128-134	lactoperoxidase	Homo sapiens	31-34
8870668-3	1996	Like native HST, the recombinant protein can bind two ferric ions in the presence of bicarbonate, and is actively taken up by receptor-mediated endocytosis.	Ferric enterobactin ion	54-60	fibroblast growth factor 4	Homo sapiens	12-15
8905632-4	1996	EDTA al so reduces LPO-compound-11 to the native ferric state by one-electron transfer as evidenced by the spectral shift from 428 to 412 nm.	Ferric enterobactin ion	49-55	lactoperoxidase	Homo sapiens	19-22
8660685-0	1996	Interaction of ferric complexes with NADH-cytochrome b5 reductase and cytochrome b5: lipid peroxidation, H2O2 generation, and ferric reduction.	Ferric enterobactin ion	15-21	cytochrome b5 type A	Homo sapiens	42-55
8660685-0	1996	Interaction of ferric complexes with NADH-cytochrome b5 reductase and cytochrome b5: lipid peroxidation, H2O2 generation, and ferric reduction.	Ferric enterobactin ion	15-21	cytochrome b5 type A	Homo sapiens	70-83
8660685-0	1996	Interaction of ferric complexes with NADH-cytochrome b5 reductase and cytochrome b5: lipid peroxidation, H2O2 generation, and ferric reduction.	Ferric enterobactin ion	126-132	cytochrome b5 type A	Homo sapiens	70-83
8660685-12	1996	These results indicate that the ability of NADH reductase and cytochrome b5 to interact with various ferric complexes depends on the nature of the chelating agent used to complex the iron and on the concentration of the iron.	Ferric enterobactin ion	101-107	cytochrome b5 type A	Homo sapiens	62-75
7608158-12	1995	Ferrous H64V/V68H myoglobin binds CO and NO to form stable complexes, but its reaction with O2 results in a rapid autooxidation to the ferric species.	Ferric enterobactin ion	135-141	myoglobin	Sus scrofa	18-27
8554320-12	1995	It is concluded that cytochrome b5 is required for reduction of low and high concentrations of ferric-histidine and ferric-ammonium sulfate and low concentrations of ferric-ATP and for the lipid peroxidation catalyzed by these ferric complexes.	Ferric enterobactin ion	95-101	cytochrome b5 type A	Homo sapiens	21-34
7580053-5	1995	Citrate and urate inhibit the iron-ceruloplasmin-dependent ascorbate oxidation by chelating ferric ions.	Ferric enterobactin ion	92-98	ceruloplasmin	Homo sapiens	35-48
7642502-9	1995	ADH is a homotetramer with a subunit M(r) of 46,000 and contains 1 g-atom of Fe per subunit, which, as determined by electron paramagnetic resonance analyses, is present as a mixture of ferrous and ferric forms.	Ferric enterobactin ion	198-204	iron-containing alcohol dehydrogenase	Thermococcus paralvinellae	0-3
22060567-5	1996	Differential scanning calorimetry, reflectance spectrophotometry and electrophoresis showed that treatment above 300-400 MPa caused marked denaturation of the myofibrillar and sarcoplasmic proteins and conversion of reduced myoglobin/oxymyoglobin to the denatured ferric form.	Ferric enterobactin ion	264-270	myoglobin	Homo sapiens	224-233
8633080-1	1996	The expression of at least 24 distinct genes of Pseudomonas aeruginosa PAO1 is under direct control of the "ferric uptake regulator" (Fur).	Ferric enterobactin ion	108-114	ferric uptake regulation protein	Pseudomonas aeruginosa PAO1	134-137
8548503-1	1996	The iron-binding protein transferrin has major roles in transporting, delivering, and sequestering ferric ions acquired by body tissues.	Ferric enterobactin ion	99-105	transferrin	Homo sapiens	25-36
7492589-1	1995	A resonance Raman spectroscopic study of the porcine myoglobin double mutant H64V/V68H has confirmed that the ferric form is bis-histidine ligated, has revealed that the bis-histidine ligation is retained on reduction to the ferrous form, and has demonstrated that CO can displace the ligated distal histidine to produce a ferrous CO form which has a low steady-state photolability, indicating that the replacement histidine blocks the CO escape route from the binding site.	Ferric enterobactin ion	110-116	myoglobin	Homo sapiens	53-62
7639530-6	1995	Addition of ferric ions to DHB only partially restores the NF-kappa B induction by H2O2, while this effect is almost completely restored by ferric ion addition to DHB-EE.	Ferric enterobactin ion	12-18	nuclear factor kappa B subunit 1	Homo sapiens	59-69
7819206-1	1995	The ferric form of soybean lipoxygenase catalyzes an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce iodide ions and 9,11-octadecadienoic acid (9, 11-ODA).	Ferric enterobactin ion	4-10	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7947969-6	1994	One heme group (protoporphyrin IX with an iron atom in the ferric state) is associated with one molecule of hCP.	Ferric enterobactin ion	59-65	coproporphyrinogen oxidase	Homo sapiens	108-111
8397139-2	1993	Recently, ferric ion chelated to citrate (Fe-citrate) was identified as the major non-transferrin-bound iron in the serum of GH patients.	Ferric enterobactin ion	10-16	transferrin	Homo sapiens	86-97
7947698-1	1994	Mitochondrial and microsomal cytochromes P-450SCC and P-450LM2 in the ferric substrate-free and substrate-bound states were studied by resonance Raman spectroscopy.	Ferric enterobactin ion	70-76	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	41-49
7860417-2	1994	Accumulated biological information led to a plausible model for the role of testicular transferrin in an iron shuttle system designed to transport ferric ions around the cellular tight junctions to the germ cells inside the blood-testis barrier.	Ferric enterobactin ion	147-153	transferrin	Homo sapiens	87-98
8151309-1	1994	Serum transferrin is the mammalian protein whose normal function is to transport ferric ions through the blood among sites of absorption, storage, and utilization.	Ferric enterobactin ion	81-87	transferrin	Homo sapiens	6-17
8125933-6	1994	Spectroscopic studies show that the Kd value for binding of linoleic acid to myoglobin is similar to the Km value for its oxidation and indicate that linoleic acid reduces the ferryl species to the ferric state.	Ferric enterobactin ion	198-204	myoglobin	Physeter catodon	77-86
8396885-4	1993	The reaction was inhibited by sulfhydryl reagents, was heat labile, and may account for reduction of ferric to ferrous iron during hepatic iron uptake from transferrin or from other iron sources.	Ferric enterobactin ion	101-107	transferrin	Rattus norvegicus	156-167
7975371-2	1994	In the healthy animals activity of aldose reductase was distinctly increased in the presence of ferric ions and of microsomal membranes; desferal inhibited drastically the enzyme activity.	Ferric enterobactin ion	96-102	aldo-keto reductase family 1 member B1	Rattus norvegicus	35-51
7910035-0	1994	Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states.	Ferric enterobactin ion	142-148	guanylate cyclase	Bos taurus	8-25
8369310-0	1993	Calorimetric studies of the binding of ferric ions to human serum transferrin.	Ferric enterobactin ion	39-45	transferrin	Homo sapiens	66-77
8369310-1	1993	The binding of ferric ions, chelated with nitrilotriacetate, to human serum transferrin (hTF) has been studied using ultrasensitive titration calorimetry.	Ferric enterobactin ion	15-21	transferrin	Homo sapiens	76-87
8340253-0	1993	Transforming growth factor-alpha expression of renal proximal tubules in Wistar rats treated with ferric and aluminum nitrilotriacetate.	Ferric enterobactin ion	98-104	transforming growth factor alpha	Rattus norvegicus	0-32
7686874-13	1993	The conversion of compound II to ferric MPO by DFO optimized the enzymatic activity of neutrophils, and in the presence of monochlorodimedon (compound II promoting agent) we measured an increased HOCl production.	Ferric enterobactin ion	33-39	myeloperoxidase	Homo sapiens	40-43
8501465-0	1993	Binding of the ferric uptake regulation repressor protein (Fur) to Mn(II), Fe(II), Co(II), and Cu(II) ions as co-repressors: electronic absorption, equilibrium, and 57Fe Mossbauer studies.	Ferric enterobactin ion	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
1315759-1	1992	One proposed mechanism of the inactivation of lipoxygenase by inhibitors is the reduction of the catalytically active ferric form of the enzyme to its ferrous form.	Ferric enterobactin ion	118-124	linoleate 9S-lipoxygenase-4	Glycine max	46-58
1303766-7	1992	Removal of the bound ferric ions (apo-Tf) did not alter the overall conformation, but there were subtle changes in local conformation based on its near-UV CD spectrum.	Ferric enterobactin ion	21-27	transferrin	Homo sapiens	38-40
8388915-8	1993	Proton NMR spectra of lactoperoxidase in the presence of excess thiocyanate ion illustrated the retention of a high-spin ferric configuration consistent with predominant binding of the physiological thiocyanate substrate at a non-heme site at room temperature.	Ferric enterobactin ion	121-127	lactoperoxidase	Bos taurus	22-37
8094100-1	1993	Lactoferrin (LF) and transferrin (Trf) are glycoproteins with strong affinities for ferric ions.	Ferric enterobactin ion	84-90	transferrin	Homo sapiens	21-32
8094100-1	1993	Lactoferrin (LF) and transferrin (Trf) are glycoproteins with strong affinities for ferric ions.	Ferric enterobactin ion	84-90	transferrin	Homo sapiens	34-37
1333417-1	1992	EPR (electron paramagnetic resonance) and optical spectroscopy show that human neutrophil myeloperoxidase is converted from ferric high-spin to low-spin by the addition of nitrite.	Ferric enterobactin ion	124-130	myeloperoxidase	Homo sapiens	90-105
1333795-12	1992	The one-dimensional 1H NMR spectrum of the OM cytochrome b5 indicates that the rhombic perturbation of the ferric center is essentially identical to that in the microsomal beef, rabbit, chicken, and rat cytochromes b5.	Ferric enterobactin ion	107-113	cytochrome b5	Oryctolagus cuniculus	46-59
1850741-5	1991	This brings to (at least) five the number of classes of lipoxygenase inhibitors that are capable of reducing the active-site ferric ion and suggests the generality of this approach in the rational design of lipoxygenase inhibitors.	Ferric enterobactin ion	125-131	linoleate 9S-lipoxygenase-4	Glycine max	56-68
1794978-3	1991	In the oxidized form, the Soret band was red-shifted as compared with the typical ferric low-spin form of P450 and the beta band was more intense than the alpha band.	Ferric enterobactin ion	82-88	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	106-110
1791469-0	1991	On the interaction of phosvitins with ferric ion: solubility of the Fe(III)-phosphoprotein complex under acidic conditions is a function of the iron/phosphate ratio and the degree of phosvitin phosphorylation.	Ferric enterobactin ion	38-44	casein kinase 2 beta	Homo sapiens	22-31
2065674-8	1991	Analytical and spectroscopic data indicated that fractional rates and equilibria for disassembly of the ferric complex in the presence of apoferritin were independent of the concentration of the protein and of the complex itself.	Ferric enterobactin ion	104-110	ferritin heavy chain 1	Homo sapiens	138-149
1656885-4	1991	The unprocessed recombinant protein displays the characteristic light absorption spectra of ferric mature MPO and exhibits its typical spectral changes in the presence of dithionite or hydrogen peroxide.	Ferric enterobactin ion	92-98	myeloperoxidase	Homo sapiens	106-109
1660264-7	1991	The three-dimensional X-ray structures of rabbit serum transferrin and human lactoferrin have shown that the ferric cations are co-ordinated by four protein ligands and a bidentate carbonate anion in a distorted octahedral arrangement [Anderson, Baker, Dodson, Norris, Rumball, Waters & Baker (1987) Proc.	Ferric enterobactin ion	109-115	transferrin	Homo sapiens	55-66
1910584-11	1991	These results suggested that autoxidation of heme and of ferrous ions to the unusable ferric form largely contribute toward the oxygen sensitivity of the ferrochelatase reaction in vitro.	Ferric enterobactin ion	86-92	ferrochelatase	Rattus norvegicus	154-168
1850741-5	1991	This brings to (at least) five the number of classes of lipoxygenase inhibitors that are capable of reducing the active-site ferric ion and suggests the generality of this approach in the rational design of lipoxygenase inhibitors.	Ferric enterobactin ion	125-131	linoleate 9S-lipoxygenase-4	Glycine max	207-219
2037047-2	1991	Results on the reactivity on both ferric and ferrous wild type and mutants Mb"s are presented.	Ferric enterobactin ion	34-40	myoglobin	Physeter catodon	75-77
1846742-2	1991	Reduction of nitrate, or nitrite, to N2O under aerobic conditions involves NO as an intermediate, as judged by trapping experiments with the ferric form of extracellular horse heart cytochrome c and the demonstration that the cells possess a nitric oxide reductase activity.	Ferric enterobactin ion	141-147	cytochrome c, somatic	Equus caballus	182-194
1846361-1	1991	The resonance Raman spectra of neutrophil cytochrome b558 obtained upon Soret excitation indicate that the heme is low spin six-coordinate in both ferric and ferrous oxidation states; comparison with the spectra of bis-imidazole hemin suggests imidazole or imidazolate axial ligation.	Ferric enterobactin ion	147-153	mitochondrially encoded cytochrome b	Homo sapiens	42-54
1703937-6	1990	At low concentrations the relaxivities of iron in serum, about 0.91 mmol-1 l s-1 for ferric and 0.95 mmol-1 l s-1 for ferrous ion, approximate well to the relaxivity of iron in transferrin solutions, which was measured to be about 0.92 mmol-1 l s-1.	Ferric enterobactin ion	85-91	transferrin	Homo sapiens	177-188
1977818-6	1990	However, calmodulin antagonists considerably inhibited radiation-induced lipid peroxidation in the presence of ferric (Fe3+) ions.	Ferric enterobactin ion	111-117	calmodulin 1	Rattus norvegicus	9-19
2176837-2	1990	Resonance Raman spectra of the purified sample revealed that the heme iron adopts the pure pentacoordinated ferric high-spin state on the basis of the nu 10 (1629cm-1) and nu 3 (1490 cm-1) mode frequencies, which are higher than those of the hexacoordinated ferric high-spin cytochrome P-450scc-substrate complexes.	Ferric enterobactin ion	108-114	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	275-294
2158989-2	1990	The low-spin, cyanide-ligated ferric complex of the intact bovine granulocyte myeloperoxidase (MPO-CN) has been studied by proton nuclear magnetic resonance utilizing the nuclear Overhauser effect (NOE).	Ferric enterobactin ion	30-36	myeloperoxidase	Bos taurus	78-93
2158989-2	1990	The low-spin, cyanide-ligated ferric complex of the intact bovine granulocyte myeloperoxidase (MPO-CN) has been studied by proton nuclear magnetic resonance utilizing the nuclear Overhauser effect (NOE).	Ferric enterobactin ion	30-36	myeloperoxidase	Bos taurus	95-98
1970297-2	1990	Vitellogenin conjugated to colloidal ferric particles of ca.	Ferric enterobactin ion	37-43	a1-a	Xenopus laevis	0-12
2161619-0	1990	Generation of reactive oxygen species and reduction of ferric chelates by microsomes in the presence of a reconstituted system containing ethanol, NAD+ and alcohol dehydrogenase.	Ferric enterobactin ion	55-61	aldo-keto reductase family 1 member A1	Homo sapiens	156-177
2161619-2	1990	Experiments were conducted to evaluate whether NADH generated from a reconstituted system containing ethanol plus NAD+ plus ADH could interact with ferric chelates to promote microsomal lipid peroxidation and generation of a hydroxyl radical (OH)-like species.	Ferric enterobactin ion	148-154	aldo-keto reductase family 1 member A1	Homo sapiens	48-51
1970297-4	1990	Several cortical membrane compartments, labeled or unlabeled with ferric particles, are involved in the internalization and the transfer of vitellogenin to the yolk platelets.	Ferric enterobactin ion	66-72	a1-a	Xenopus laevis	140-152
34310960-6	2021	Then H2O2 not only damaged structure of Tf to release Fe3+, but also was converted to hydroxyl radicals via ferric ions mediated Fenton reaction for ferroptosis.	Ferric enterobactin ion	108-114	transferrin	Homo sapiens	40-42
34973332-10	2022	Moreover, the change in bioavailable heme due to HO-2 overexpression, which selectively binds ferric over ferrous heme, is consistent with the labile heme pool being oxidized, thereby providing new insights into heme trafficking and signaling.	Ferric enterobactin ion	94-100	heme oxygenase 2	Homo sapiens	49-53
34783530-0	2021	Contrasting Effects of Ferric and Ferrous Ions on Oligomerization and Droplet Formation of Tau: Implications in Tauopathies and Neurodegeneration.	Ferric enterobactin ion	23-29	microtubule associated protein tau	Homo sapiens	91-94
34783530-2	2021	Herein, we found that ferric (Fe3+) ions enhanced tau aggregation.	Ferric enterobactin ion	22-28	microtubule associated protein tau	Homo sapiens	50-53
34581604-6	2021	The ferric uptake regulator, Fur, was found to repress traD transcript levels, but to also have a second role, acting to allow TraD protein levels to increase only in the absence of iron.	Ferric enterobactin ion	4-10	TraD	Neisseria gonorrhoeae	55-59
34581604-6	2021	The ferric uptake regulator, Fur, was found to repress traD transcript levels, but to also have a second role, acting to allow TraD protein levels to increase only in the absence of iron.	Ferric enterobactin ion	4-10	TraD	Neisseria gonorrhoeae	127-131
2095335-6	1990	Although ferrous, ferric, cobalt, and manganese ions were highly inhibitory to beta-man, they also inhibited other lysosomal hydrolases to a similar extent.	Ferric enterobactin ion	18-24	mannosidase beta	Homo sapiens	79-87
34310960-8	2021	Therefore, based on calcium and ferric ions interference strategy, the cascade catalytic CaO2/Tf/CUR offered synergistic combination of ferroptosis, Ca2+ overload therapy and chemotherapy, which held a great promise in cancer treatment.	Ferric enterobactin ion	32-38	transferrin	Homo sapiens	94-96
34360097-3	2021	The concentration of zinc (Zn) and copper (Cu) in the serum was determined by Atomic Absorption Spectrometry (AAS) and the total antioxidative potential by the Ferric Reducing Ability of Plasma (FRAP) method.	Ferric enterobactin ion	160-166	mechanistic target of rapamycin kinase	Homo sapiens	195-199
34512783-10	2021	Results of the FRAP test represented very strong ferric ion reducing activities (0.04-0.83 mmol Fe2+/g).	Ferric enterobactin ion	49-55	mechanistic target of rapamycin kinase	Homo sapiens	15-19
34347312-2	2021	The presence of catechol moiety in dopamine was exploited to form pH-responsive cross-links with ferric ions (Fe3+ ) at different pH value.	Ferric enterobactin ion	97-103	phenylalanine hydroxylase	Homo sapiens	66-68
34347312-2	2021	The presence of catechol moiety in dopamine was exploited to form pH-responsive cross-links with ferric ions (Fe3+ ) at different pH value.	Ferric enterobactin ion	97-103	phenylalanine hydroxylase	Homo sapiens	130-132
34065292-2	2021	The antioxidant activity of both latex (ADL) and the methanolic extract of leaves (ADM) is determined using 1-diphenyl-2-picrylhydrazyl (DPPH), 2,2"-azino-bis 3-ethylbenzothiazoline-6-sulphonic acid (ABTS) scavenging radical methods and ferric reducing/antioxidant power (FRAP) assay.	Ferric enterobactin ion	237-243	adrenomedullin	Mus musculus	83-86
34110158-2	2021	Here, we report biochemical, biophysical, and computational analyses revealing that 1H-indazole-4-amines inhibit both hIDO1 and hTDO by a mechanism involving direct coordination with the heme ferrous and ferric states.	Ferric enterobactin ion	204-210	indoleamine 2,3-dioxygenase 1	Homo sapiens	118-123
34110158-2	2021	Here, we report biochemical, biophysical, and computational analyses revealing that 1H-indazole-4-amines inhibit both hIDO1 and hTDO by a mechanism involving direct coordination with the heme ferrous and ferric states.	Ferric enterobactin ion	204-210	tryptophan 2,3-dioxygenase	Homo sapiens	128-132
34073216-3	2021	We demonstrated that the "redox state Raman marker" of the ferric low-spin heme in cytochrome c at 1584 cm-1 can serve as a sensitive indicator of cancer aggressiveness.	Ferric enterobactin ion	59-65	cytochrome c, somatic	Homo sapiens	83-95
35636779-10	2022	Also, IL-37 had a significantly positive correlation with ferric-reducing antioxidant power (FRAP) assay.	Ferric enterobactin ion	58-64	interleukin 37	Homo sapiens	6-11
35613428-2	2022	Currently, the widely accepted mechanisms of the anti-inflammatory effects for Ga3+ are rationalized on the basis of their similarities to ferric ions (Fe3+), which permits Ga3+ to bind with Fe-binding proteins and subsequently disturbs the Fe homeostasis in the immune cells.	Ferric enterobactin ion	139-145	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	79-82
35613428-2	2022	Currently, the widely accepted mechanisms of the anti-inflammatory effects for Ga3+ are rationalized on the basis of their similarities to ferric ions (Fe3+), which permits Ga3+ to bind with Fe-binding proteins and subsequently disturbs the Fe homeostasis in the immune cells.	Ferric enterobactin ion	139-145	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	173-176
3059280-1	1988	Lactoferrin and transferrin exhibit very similar structure and biochemical properties but they behave as two distinct antigens and their affinity for ferric ions is not of the same magnitude.	Ferric enterobactin ion	150-156	transferrin	Homo sapiens	16-27
35592205-1	2022	Methemoglobin (MetHb) is a form of hemoglobin in which iron in Hb is in an oxidized form (ferric) instead of ferrous, making it difficult to bind with oxygen.	Ferric enterobactin ion	90-96	hemoglobin subunit gamma 2	Homo sapiens	0-13
34988564-7	2022	A significant increase in the ferric reducing ability of plasma (FRAP), Trolox equivalent antioxidant capacity (TEAC), and thiol level, all measures of antioxidant capacity, was also observed in the participants who consumed the HCMF meal accompanied by RRB.	Ferric enterobactin ion	30-36	mechanistic target of rapamycin kinase	Homo sapiens	65-69
2556968-0	1989	NADH-dependent microsomal interaction with ferric complexes and production of reactive oxygen intermediates.	Ferric enterobactin ion	43-49	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-4
2556968-2	1989	Experiments were carried out to characterize the ability of NADH to interact with various ferric chelates to promote microsomal lipid peroxidation and generation of .OH-like species.	Ferric enterobactin ion	90-96	2,4-dienoyl-CoA reductase 1	Homo sapiens	60-64
2556968-10	1989	NADH-dependent lipid peroxidation was much lower than the NADPH-catalyzed reaction and showed an opposite response to catalysis by ferric complexes compared to .OH generation as production of thiobarbituric acid-reactive material was increased with ferric-ATP and -citrate, but not with ferric-EDTA or- DTPA, and was not affected by catalase, SOD, or .OH scavengers.	Ferric enterobactin ion	131-137	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-4
2556968-11	1989	These results indicate that NADH can support microsomal reduction of ferric chelates, with the subsequent production of .OH-like species and peroxidation of lipids.	Ferric enterobactin ion	69-75	2,4-dienoyl-CoA reductase 1	Homo sapiens	28-32
2916994-3	1989	In native yellow fin tuna myoglobin, changes in heme orientational preferences of approximately 3 kJ/mol occur even between two six-coordinate ferric states differing solely in spin states.	Ferric enterobactin ion	143-149	myoglobin	Physeter catodon	26-35
2665999-12	1989	In plasma, the ferrous iron is converted into the ferric form via the action of ceruloplasmin.	Ferric enterobactin ion	50-56	ceruloplasmin	Homo sapiens	80-93
3379048-2	1988	The uptake of iron from transferrin by isolated rat hepatocytes varies in parallel with plasma membrane NADH:ferricyanide oxidoreductase activity, is inhibited by ferricyanide, ferric, and ferrous iron chelators, divalent transition metal cations, and depends on calcium ions.	Ferric enterobactin ion	109-115	transferrin	Rattus norvegicus	24-35
3177366-0	1988	Effect of ferrous and ferric chelators on transferrin-iron-macrophage interactions.	Ferric enterobactin ion	22-28	transferrin	Homo sapiens	42-53
3177366-1	1988	A study was done to evaluate the effect of ferrous and ferric chelators on the interaction between transferrin-iron and cultured human blood monocytes.	Ferric enterobactin ion	55-61	transferrin	Homo sapiens	99-110
3169362-2	1988	The present kinetic study suggests that the Fe(II)-adriamycin complex acts as substrate for ceruloplasmin, which oxidizes the complex to the ferric form (Km = 21.7 microM).	Ferric enterobactin ion	141-147	ceruloplasmin	Homo sapiens	92-105
3377511-0	1988	Interaction of gastrin with transferrin: effects of ferric ions.	Ferric enterobactin ion	52-58	gastrin	Homo sapiens	15-22
3578500-10	1987	The results can be explained if the iron is released from the transferrin in intracellular vesicles in the ferrous form, where it may be chelated by bipyridine and prevented from passing to the fetus or converted to the ferric form once it is inside the cell matrix.	Ferric enterobactin ion	220-226	transferrin	Rattus norvegicus	62-73
3593741-3	1987	Using the valency hybrid hemoglobins thus prepared, the effect of the ferric spin state on the alpha 1 beta 2 subunit boundary structure was investigated by measuring the ultraviolet difference absorption spectra between the deoxy and the oxy valency hybrids associated with various ferric ligands (fluoride, aquo, azide and cyanide).	Ferric enterobactin ion	70-76	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	103-109
3784891-6	1986	Measurements of 1/T2 at 20 MHz are quite in accord with theoretical expectations for apoferritin and ferritin with up to 24 ferric ions per molecule.	Ferric enterobactin ion	124-130	ferritin heavy chain 1	Homo sapiens	85-96
2822673-5	1987	Myeloperoxidase compound I reacted with H2O2 and returned to the ferric state with concomitant evolution of an O2 molecule.	Ferric enterobactin ion	65-71	myeloperoxidase	Homo sapiens	0-15
3023322-2	1986	In the lactoperoxidase (LPO)-H2O2 system, at low H2O2 concentrations and/or alkaline conditions the peroxidatic cycle involves ferric LPO----compound I----compound II----ferric LPO conversion, whereas high H2O2 concentrations and/or acidic conditions favor the ferric LPO----compound I----compound II----compound III----ferrous LPO----ferric LPO pathway.	Ferric enterobactin ion	127-133	lactoperoxidase	Homo sapiens	7-22
3023322-2	1986	In the lactoperoxidase (LPO)-H2O2 system, at low H2O2 concentrations and/or alkaline conditions the peroxidatic cycle involves ferric LPO----compound I----compound II----ferric LPO conversion, whereas high H2O2 concentrations and/or acidic conditions favor the ferric LPO----compound I----compound II----compound III----ferrous LPO----ferric LPO pathway.	Ferric enterobactin ion	127-133	lactoperoxidase	Homo sapiens	24-27
3023322-2	1986	In the lactoperoxidase (LPO)-H2O2 system, at low H2O2 concentrations and/or alkaline conditions the peroxidatic cycle involves ferric LPO----compound I----compound II----ferric LPO conversion, whereas high H2O2 concentrations and/or acidic conditions favor the ferric LPO----compound I----compound II----compound III----ferrous LPO----ferric LPO pathway.	Ferric enterobactin ion	127-133	lactoperoxidase	Homo sapiens	134-137
3023322-2	1986	In the lactoperoxidase (LPO)-H2O2 system, at low H2O2 concentrations and/or alkaline conditions the peroxidatic cycle involves ferric LPO----compound I----compound II----ferric LPO conversion, whereas high H2O2 concentrations and/or acidic conditions favor the ferric LPO----compound I----compound II----compound III----ferrous LPO----ferric LPO pathway.	Ferric enterobactin ion	127-133	lactoperoxidase	Homo sapiens	134-137
3023322-2	1986	In the lactoperoxidase (LPO)-H2O2 system, at low H2O2 concentrations and/or alkaline conditions the peroxidatic cycle involves ferric LPO----compound I----compound II----ferric LPO conversion, whereas high H2O2 concentrations and/or acidic conditions favor the ferric LPO----compound I----compound II----compound III----ferrous LPO----ferric LPO pathway.	Ferric enterobactin ion	127-133	lactoperoxidase	Homo sapiens	134-137
3023322-2	1986	In the lactoperoxidase (LPO)-H2O2 system, at low H2O2 concentrations and/or alkaline conditions the peroxidatic cycle involves ferric LPO----compound I----compound II----ferric LPO conversion, whereas high H2O2 concentrations and/or acidic conditions favor the ferric LPO----compound I----compound II----compound III----ferrous LPO----ferric LPO pathway.	Ferric enterobactin ion	127-133	lactoperoxidase	Homo sapiens	134-137
3023322-2	1986	In the lactoperoxidase (LPO)-H2O2 system, at low H2O2 concentrations and/or alkaline conditions the peroxidatic cycle involves ferric LPO----compound I----compound II----ferric LPO conversion, whereas high H2O2 concentrations and/or acidic conditions favor the ferric LPO----compound I----compound II----compound III----ferrous LPO----ferric LPO pathway.	Ferric enterobactin ion	127-133	lactoperoxidase	Homo sapiens	134-137
3021127-3	1986	Perhydroxyl or superoxide radicals (HO.2 or O-2) cannot be established as the inactivating species in this mechanism, but they influence the rate of reconversion of the intermediate lactoperoxidase-compound III back to the resting ferric form of the enzyme.	Ferric enterobactin ion	231-237	immunoglobulin kappa variable 1D-39	Homo sapiens	44-47
3091080-6	1986	When purified ferrochelatase was incubated with the low molecular weight form of NADH dehydrogenase prepared from Complex I, heme synthesis from ferric ion occurred by the addition of NADH.	Ferric enterobactin ion	145-151	FECH	Bos taurus	14-28
3019383-2	1986	The assignment of the electron paramagnetic resonance spectrum of PAH to two, overlapping high-spin ferric signals is confirmed by computer simulation.	Ferric enterobactin ion	100-106	phenylalanine hydroxylase	Homo sapiens	66-69
2985447-1	1985	The resonance Raman spectra of ferric derivatives of myeloperoxidase at pH 8 show ligand-dependent differences.	Ferric enterobactin ion	31-37	myeloperoxidase	Homo sapiens	53-68
4074838-4	1985	An unusual feature of the stepwise structural changes of transferrin upon iron saturation is that binding of the first ferric ion is responsible for more than half of the whole change in Rq, whereas Rg alters significantly only after the binding of the second ferric ion.	Ferric enterobactin ion	119-125	transferrin	Homo sapiens	57-68
4074838-4	1985	An unusual feature of the stepwise structural changes of transferrin upon iron saturation is that binding of the first ferric ion is responsible for more than half of the whole change in Rq, whereas Rg alters significantly only after the binding of the second ferric ion.	Ferric enterobactin ion	260-266	transferrin	Homo sapiens	57-68
3935158-0	1985	Kinetics of cytochrome P-450 reduction: evidence for faster reduction of the high-spin ferric state.	Ferric enterobactin ion	87-93	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	12-28
6468841-0	1984	Hydroxylation of deoxy guanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion.	Ferric enterobactin ion	126-132	homeobox C8	Homo sapiens	40-43
2991275-8	1985	Catalase prevented the killing by menadione of deferoxamine-pretreated hepatocytes given either ferric or ferrous iron.	Ferric enterobactin ion	96-102	catalase	Homo sapiens	0-8
6489514-0	1984	The competitive equilibrium between aluminium and ferric ions for the binding sites of transferrin.	Ferric enterobactin ion	50-56	transferrin	Homo sapiens	87-98
6489514-2	1984	Competitive equilibrium between aluminium and ferric ions for transferrin binding sites is observed, and a value of 2.5 (+/- 0.4) X 10(15) M-1 is found for the apparent binding constant under physiological conditions.	Ferric enterobactin ion	46-52	transferrin	Homo sapiens	62-73
6094249-1	1984	The decay rate of the excited triplet state of Zn cytochrome c was enhanced by electron acceptors including methyl viologen and ferric complexes of cyanide, oxalate, EDTA and cytochrome c at room temperature.	Ferric enterobactin ion	128-134	cytochrome c, somatic	Homo sapiens	50-62
6094249-1	1984	The decay rate of the excited triplet state of Zn cytochrome c was enhanced by electron acceptors including methyl viologen and ferric complexes of cyanide, oxalate, EDTA and cytochrome c at room temperature.	Ferric enterobactin ion	128-134	cytochrome c, somatic	Homo sapiens	175-187
6311622-1	1983	An assessment is made of the proposal: electrostatic interactions between the ferric ion of oxidised cytochrome c and its haem propionate sidechains assists in determining the value of the redox potential and plays an important role in the redox state conformation change.	Ferric enterobactin ion	78-84	cytochrome c, somatic	Homo sapiens	101-113
6692926-2	1984	Ceruloplasmin, a protein with ferroxidase activity, is able to catalyse oxidation of Fe2+ to the ferric state.	Ferric enterobactin ion	97-103	ceruloplasmin	Homo sapiens	0-13
6639687-15	1983	Ferric and ferrous ions, tested over widely varied concentrations, inhibited NAG release at low concentrations while enhancing NAG release at high concentrations.	Ferric enterobactin ion	0-6	O-GlcNAcase	Rattus norvegicus	77-80
6639687-15	1983	Ferric and ferrous ions, tested over widely varied concentrations, inhibited NAG release at low concentrations while enhancing NAG release at high concentrations.	Ferric enterobactin ion	0-6	O-GlcNAcase	Rattus norvegicus	127-130
6615809-9	1983	Such a result tends to support mechanisms for iron removal from transferrin in which the ferric ion is reduced to the less tightly bound ferrous ion.	Ferric enterobactin ion	89-95	transferrin	Homo sapiens	64-75
6690479-7	1984	The apparent heterogeneity in the molecular size and charge of GPBP observed during progressive purification was minimal when GPBP was saturated with ferric ions before the separation procedures.	Ferric enterobactin ion	150-156	GC-rich promoter binding protein 1	Homo sapiens	63-67
6690479-7	1984	The apparent heterogeneity in the molecular size and charge of GPBP observed during progressive purification was minimal when GPBP was saturated with ferric ions before the separation procedures.	Ferric enterobactin ion	150-156	GC-rich promoter binding protein 1	Homo sapiens	126-130
6258647-3	1981	Under a constant concentration of anion, the redox reaction of various types of cytochrome c with iron hexacyanides was analyzed according to the scheme: (see formula in text) where C(III) and C(II) are ferric and ferrous cytochromes, respectively, Fe(III) and Fe(II) are ferri- and ferrocyanides, respectively, C(III) .	Ferric enterobactin ion	203-209	cytochrome c, somatic	Equus caballus	80-92
6091691-2	1983	Binding of HCN with ferric beef heart cytochrome oxidase has been studied in submitochondrial particles, as with the enzyme solubilized in detergent or reconstituted into proteoliposomes.	Ferric enterobactin ion	20-26	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	11-14
6813118-8	1982	The results indicate that one equivalent of 13-hydroperoxylinoleic acid converts the enzyme from the ferrous state into the ferric state as described for soybean lipoxygenase-1.	Ferric enterobactin ion	124-130	seed linoleate 13S-lipoxygenase-1	Glycine max	162-176
6813118-9	1982	The spectral changes were reversed by sodium borohydride at 2 degrees C, but not at 37 degrees C; it is assumed that the ferric form of reticulocyte lipoxygenase suffers inactivation.	Ferric enterobactin ion	121-127	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	149-161
7295641-1	1981	The distance between the two metal-binding sites of human serum transferrin has been studied by observing energy transfer between an excited terbium ion bound at one site and a ferric (or manganic) ion bound at the other site of the same transferrin molecule.	Ferric enterobactin ion	177-183	transferrin	Homo sapiens	64-75
7470586-0	1981	Kinetic studies of spin interconversion in ferric mixed-spin derivatives of myoglobin.	Ferric enterobactin ion	43-49	myoglobin	Homo sapiens	76-85
464397-10	1979	In contrast to conalbumin, thermograms of serotransferrin solutions partially saturated with ferric ions exhibit only the peaks corresponding to those obtained on separate DSC scans of iron-free and iron serotransferrin, respectively.	Ferric enterobactin ion	93-99	transferrin	Homo sapiens	42-57
6779862-1	1980	The distance from the protein surface to ferric or manganic ions in the two specific metal-binding sites of human serum transferrin has been estimated by measuring energy transfer from freely diffusing terbium chelaters in aqueous solution to transferrin-bound metal ions.	Ferric enterobactin ion	41-47	transferrin	Homo sapiens	120-131
6779862-1	1980	The distance from the protein surface to ferric or manganic ions in the two specific metal-binding sites of human serum transferrin has been estimated by measuring energy transfer from freely diffusing terbium chelaters in aqueous solution to transferrin-bound metal ions.	Ferric enterobactin ion	41-47	transferrin	Homo sapiens	243-254
7188938-2	1980	Ferric complexes of phosvitin are strong and stable; ferrous complexes are weak and dissociate readily.	Ferric enterobactin ion	0-6	casein kinase 2 beta	Homo sapiens	20-29
718995-5	1978	The 448-nm product adduct of cytochrome P-450 is unstable in the ferric state or in the presence of sodium dithionite.	Ferric enterobactin ion	65-71	cytochrome P-450	Oryctolagus cuniculus	29-45
184092-3	1976	The proximal ligand to the heme iron atom of ferric soybean leghemoglobin is identified as imidazole by comparison of the EPR of leghemoglobin hydroxide, azide, and cyanide with the corresponding derivatives of human hemoglobin.	Ferric enterobactin ion	45-51	leghemoglobin A	Glycine max	129-142
10010-10	1976	Adrenal microsomal cytochrome P-450 had low spin ferric g values of 2.417, 2.244 and 1.919 and a high spin ferric gxy values of 7.90 and 3.85, distinct from the values obtained with mitochondria.	Ferric enterobactin ion	49-55	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	19-35
10010-10	1976	Adrenal microsomal cytochrome P-450 had low spin ferric g values of 2.417, 2.244 and 1.919 and a high spin ferric gxy values of 7.90 and 3.85, distinct from the values obtained with mitochondria.	Ferric enterobactin ion	107-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	19-35
184092-3	1976	The proximal ligand to the heme iron atom of ferric soybean leghemoglobin is identified as imidazole by comparison of the EPR of leghemoglobin hydroxide, azide, and cyanide with the corresponding derivatives of human hemoglobin.	Ferric enterobactin ion	45-51	leghemoglobin A	Glycine max	60-73
184843-8	1976	Approximately 0.4% of the total cytochrome P-450 was high spin ferric in control adrenals and in aerobic stimulated adrenals this rose to approximately to 0.6%.	Ferric enterobactin ion	63-69	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	32-48
8889-5	1976	The spectra of lyophilized preparations of HPp show the presence of both high and low-spin ferric species.	Ferric enterobactin ion	91-97	familial progressive hyperpigmentation 1	Homo sapiens	43-46
33714113-5	2021	ANF exhibited high ferric reducing antioxidant power (FRAP) and ABTS radical scavenging activity.	Ferric enterobactin ion	19-25	natriuretic peptide A	Rattus norvegicus	0-3
4364536-7	1974	The position of the chromic ion implies what is the path of electron transfer from the chromous ion to the ferric ion in this chemical reduction of cytochrome c, and suggests a possible path of electron transfer in biological oxidation-reduction reactions.	Ferric enterobactin ion	107-113	cytochrome c, somatic	Homo sapiens	148-160
169890-8	1975	Broad, high-spin, ferric ion electron paramagnetic resonance absorptions of catalase and myoglobin at room temperature obtained in the presence and absence of formate show that formate does not alter appreciably the heme environment of catalase or myoglobin or the spin state of the heme iron.	Ferric enterobactin ion	18-24	catalase	Equus caballus	76-84
33953326-2	2021	Plasmalemmal divalent metal ion transporter 1 (DMT1) is responsible for cellular uptake of ferrous (Fe2+), whereas transferrin receptors (TFR) carry transferrin (TF)-bound ferric (Fe3+).	Ferric enterobactin ion	172-178	transferrin receptor	Homo sapiens	115-136
33953326-2	2021	Plasmalemmal divalent metal ion transporter 1 (DMT1) is responsible for cellular uptake of ferrous (Fe2+), whereas transferrin receptors (TFR) carry transferrin (TF)-bound ferric (Fe3+).	Ferric enterobactin ion	172-178	transferrin receptor	Homo sapiens	138-141
33953326-2	2021	Plasmalemmal divalent metal ion transporter 1 (DMT1) is responsible for cellular uptake of ferrous (Fe2+), whereas transferrin receptors (TFR) carry transferrin (TF)-bound ferric (Fe3+).	Ferric enterobactin ion	172-178	transferrin	Homo sapiens	115-126
33348670-3	2020	In this work, we use site-directed spin labeling coupled to electron paramagnetic resonance (SDSL EPR) to add new information on the effects of ferric and ferrous iron binding on the properties of human frataxin in vitro.	Ferric enterobactin ion	144-150	frataxin	Homo sapiens	203-211
33922484-6	2021	In milk, lower values of the ferric reducing ability of plasma (FRAP) in the LML and HML-fed ewes and of 2,2"-Azino-bis 3-ethylbenzthiazoline-6-sulfonic acid (ABTS) in LML only, were found.	Ferric enterobactin ion	29-35	mechanistic target of rapamycin kinase	Homo sapiens	64-68
33949504-3	2021	The shortest cationanion distance between the phosphorus ion of the (PPh4)+ cation and the ferric ion of the [FeIII(HATD)2]- anion is 13.190 A in complex 1, whereas that between the ferrous ion of the [FeII(Phen)3]2+ cation and the ferric ion of the [FeIII(HATD)2]- anion is 7.821 A in complex 2.	Ferric enterobactin ion	91-97	potassium two pore domain channel subfamily K member 3	Homo sapiens	69-73
33144263-5	2021	Herein, we attempt to clarify the effects of defined thiol oxidation states on small molecule binding of cytoglobin heme, using cyanide binding to probe the ferric state.	Ferric enterobactin ion	157-163	cytoglobin	Homo sapiens	105-115
33256027-1	2020	Methemoglobin (MetHb) is a hemoglobin (Hb) derivative with the heme iron in ferric state (Fe3+), unable to deliver oxygen.	Ferric enterobactin ion	76-82	hemoglobin subunit gamma 2	Homo sapiens	0-13
33256027-1	2020	Methemoglobin (MetHb) is a hemoglobin (Hb) derivative with the heme iron in ferric state (Fe3+), unable to deliver oxygen.	Ferric enterobactin ion	76-82	hemoglobin subunit gamma 2	Homo sapiens	15-20
32833426-8	2020	Adropin successfully restored striatal DA; attenuated rotenone-induced motor/behaviour deficits along with strong gastroprotective potential, possibly through antioxidant activity via reduction in malondialdehyde level and upregulated superoxide dismutase, catalase activities and serum ferric reducing antioxidant power.	Ferric enterobactin ion	287-293	energy homeostasis associated	Rattus norvegicus	0-7
33157356-7	2020	Furthermore, we found that ferric ion (Fe3+) but not biliverdin and carbon monoxide, products of heme degradation by HO-1, mediated the HO-1-induced anti-DTMUV effect.	Ferric enterobactin ion	27-33	heme oxygenase 1	Homo sapiens	136-140
32146510-3	2020	Here, the kinetics of cyanide and carbon monoxide dissociation from ferrous-ligated Hp:Hb complexes are reported at pH 7.0 and 20.0  C. Cyanide dissociation from Hp1-1:Hb(II)-CN- and Hp2-2:Hb-CN- has been followed upon the dithionite-mediated conversion of ferric to ferrous-ligated Hp:Hb complexes.	Ferric enterobactin ion	257-263	chromobox 5	Homo sapiens	162-167
32785027-3	2020	We estimated TDAC among these individuals by calculating a ferric reducing ability of plasma (FRAP) score based on data from food-frequency questionnaires.	Ferric enterobactin ion	59-65	mechanistic target of rapamycin kinase	Homo sapiens	94-98
32246282-10	2020	The green color is caused by a blueshift of the CT1 band that is characteristic of the high spin ferric state of the enzyme.	Ferric enterobactin ion	97-103	cardiotrophin 1	Homo sapiens	48-51
32537936-3	2020	Here, the prodrug tirapazamine (TPZ)-loaded human serum albumin (HSA)-glucose oxidase (GOx) mixture is prepared and modified with a metal-polyphenol network composed of ferric ions (Fe3+ ) and tannic acid (TA), to obtain a self-amplified nanoreactor termed HSA-GOx-TPZ-Fe3+ -TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H2 O2 production and TA-accelerated Fe3+ /Fe2+ conversion.	Ferric enterobactin ion	169-175	albumin	Homo sapiens	50-85
32537936-3	2020	Here, the prodrug tirapazamine (TPZ)-loaded human serum albumin (HSA)-glucose oxidase (GOx) mixture is prepared and modified with a metal-polyphenol network composed of ferric ions (Fe3+ ) and tannic acid (TA), to obtain a self-amplified nanoreactor termed HSA-GOx-TPZ-Fe3+ -TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H2 O2 production and TA-accelerated Fe3+ /Fe2+ conversion.	Ferric enterobactin ion	169-175	hydroxyacid oxidase 1	Homo sapiens	87-90
32587293-4	2020	Using X-ray spectromicroscopy and electron microscopy we found that the co-aggregation of Abeta and ferritin resulted in the conversion of ferritin"s inert ferric core into more reactive low-oxidation-states.	Ferric enterobactin ion	156-162	amyloid beta precursor protein	Homo sapiens	90-95
31436417-3	2019	These consequential effects are regulated through redox changes in the heme cofactor of IDO1, which autoxidizes to the inactive ferric state during turnover.	Ferric enterobactin ion	128-134	indoleamine 2,3-dioxygenase 1	Homo sapiens	88-92
32172452-0	2020	Ferric nitrosylated myoglobin catalyzes peroxynitrite scavenging.	Ferric enterobactin ion	0-6	myoglobin	Homo sapiens	20-29
32341999-4	2020	The resulting SBP-bound ferric siderophore complex is ready for import through an associated membrane permease and enzymatic turnover is achieved through cofactor replacement from the readily available pool of extracellular siderophores.	Ferric enterobactin ion	24-30	selenium binding protein 1	Homo sapiens	14-17
32209682-3	2020	Here, we dissected a regulatory network directed by the conserved iron homeostasis regulator, ferric uptake regulator (Fur), in uropathogenic E. coli (UPEC) strain CFT073.	Ferric enterobactin ion	94-100	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	119-122
32123514-6	2019	Ferric reducing activity was <0.01, with significantly different effects across hop cultivars (pC<=0.05) and year (py<=0.05) observed only in 2012.	Ferric enterobactin ion	0-6	HOP homeobox	Homo sapiens	80-83
31540400-6	2019	Total antioxidant potential was determined spectrophotometrically using the FRAP method (ferric ion reducing antioxidant parameter) by measuring total FRAP and uric acid (UA)-independent FRAP (FRAP-UA).	Ferric enterobactin ion	89-95	mechanistic target of rapamycin kinase	Homo sapiens	76-80
31229855-3	2019	Herein, we constructed a positive feedback nanoamplifier by encapsulating glucose oxidase (GOx) in the ferric ions contained metal organic framework (MIL-100), and coating the nanoparticles with polydopamine modified hyaluronic acid (HA-PDA).	Ferric enterobactin ion	103-109	hydroxyacid oxidase 1, liver	Mus musculus	74-89
31399939-4	2019	We estimated the dietary antioxidant capacity for 5796 participants of the Rotterdam Study using a ferric reducing ability of plasma (FRAP) score.	Ferric enterobactin ion	99-105	mechanistic target of rapamycin kinase	Homo sapiens	134-138
31229855-3	2019	Herein, we constructed a positive feedback nanoamplifier by encapsulating glucose oxidase (GOx) in the ferric ions contained metal organic framework (MIL-100), and coating the nanoparticles with polydopamine modified hyaluronic acid (HA-PDA).	Ferric enterobactin ion	103-109	hydroxyacid oxidase 1, liver	Mus musculus	91-94
30864809-1	2019	Human serum transferrin (sTf) can also function as a noniron metal transporter since only 30% of it is typically saturated with a ferric ion.	Ferric enterobactin ion	130-136	transferrin	Homo sapiens	12-23
31311981-12	2019	Surface functionalization of MFC using enzyme (hexokinase) was performed to increase the adsorption efficiency towards ferric ions removal.	Ferric enterobactin ion	119-125	hexokinase 1	Homo sapiens	47-57
30771633-8	2019	TOC and UV-Vis analyses indicated that ferric ions replaced lead ions, resulting in the conversion of the EDTA-chelated Pb(II) to EDTA-chelated Fe(III).	Ferric enterobactin ion	39-45	submaxillary gland androgen regulated protein 3B	Homo sapiens	120-126
30474149-2	2019	One of the main catalysts of this process is iron, which is introduced in its ferric (Fe(III)) form via phosvitin, an egg yolk phosphoprotein rich in phosphoserines.	Ferric enterobactin ion	78-84	casein kinase 2 beta	Homo sapiens	104-113
31036221-5	2019	The relative fluorescence intensity versus ferric ions concentration yielded a good linear calibration in the range of 10.0-1000.0 muM (R2 = 0.998) and the limit of detection was 4.1 muM.	Ferric enterobactin ion	43-49	latexin	Homo sapiens	131-134
31036221-5	2019	The relative fluorescence intensity versus ferric ions concentration yielded a good linear calibration in the range of 10.0-1000.0 muM (R2 = 0.998) and the limit of detection was 4.1 muM.	Ferric enterobactin ion	43-49	latexin	Homo sapiens	183-186
31267164-2	2019	In Hb M iron is present in the oxidized ferric state (Fe3+) not in the reduced ferrous form (Fe2+) and this reduces the ability of hemoglobin to bind oxygen.	Ferric enterobactin ion	40-46	hemoglobin subunit mu	Homo sapiens	3-7
31139371-8	2019	The free radical-scavenging activity (DPPH-), ferric reducing antioxidant power (FRAP), and beta-carotene-linoleic acid assays revealed the great antioxidant potential of the jam prepared from grape peel extract, which exhibited significant levels of radical-neutralizing activity, especially as determined by the DPPH method with EC50 values ranging from 2.3 +- 0.1 to 3.9 +- 0.1 microg/ml.	Ferric enterobactin ion	46-52	F11 receptor	Homo sapiens	175-178