PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29121804-9	2017	HO-1 was required for these anti-inflammatory effects as tin protoporphyrin IX (SnPPIX), an HO-1 inhibitor, abolished the effects of MAC on LPS-induced iNOS, NO, and NF-[Formula: see text]B activation.	tin protoporphyrin IX	80-86	nitric oxide synthase 2, inducible	Mus musculus	152-156
29121804-9	2017	HO-1 was required for these anti-inflammatory effects as tin protoporphyrin IX (SnPPIX), an HO-1 inhibitor, abolished the effects of MAC on LPS-induced iNOS, NO, and NF-[Formula: see text]B activation.	tin protoporphyrin IX	57-78	heme oxygenase 1	Mus musculus	92-96
29121804-9	2017	HO-1 was required for these anti-inflammatory effects as tin protoporphyrin IX (SnPPIX), an HO-1 inhibitor, abolished the effects of MAC on LPS-induced iNOS, NO, and NF-[Formula: see text]B activation.	tin protoporphyrin IX	57-78	nitric oxide synthase 2, inducible	Mus musculus	152-156
29121804-9	2017	HO-1 was required for these anti-inflammatory effects as tin protoporphyrin IX (SnPPIX), an HO-1 inhibitor, abolished the effects of MAC on LPS-induced iNOS, NO, and NF-[Formula: see text]B activation.	tin protoporphyrin IX	80-86	heme oxygenase 1	Mus musculus	92-96
27922667-6	2017	Moreover, while downregulation of HO-1 by the small-molecule inhibitor tin protoporphyrin (SnPP) promoted migration, upregulation of HO-1 by the small-molecule activator cobalt protoporphyrin (CoPP) showed the opposite effect.	tin protoporphyrin IX	71-89	heme oxygenase 1	Homo sapiens	34-38
27795400-4	2016	To address this controversy, we administered tin protoporphyrin IX (SnPPIX), a well-characterized HO-1 enzymatic inhibitor, to mice during acute M. tuberculosis infection.	tin protoporphyrin IX	45-66	heme oxygenase 1	Homo sapiens	98-102
27795400-4	2016	To address this controversy, we administered tin protoporphyrin IX (SnPPIX), a well-characterized HO-1 enzymatic inhibitor, to mice during acute M. tuberculosis infection.	tin protoporphyrin IX	68-74	heme oxygenase 1	Homo sapiens	98-102
27553177-4	2016	This antiviral effect of HO-1 was attenuated by its inhibitor tin protoporphyrin (SnPP), suggesting that HO-1 was an important cellular factor against DENV replication.	tin protoporphyrin IX	62-80	heme oxygenase 1	Mus musculus	25-29
27488535-5	2016	Inhibition of HO-1 by tin protoporphyrin (SnPP) or siRNA downregulated Pax3/7-FoxO1 target genes and induced a myogenic program in RMS.	tin protoporphyrin IX	22-40	heme oxygenase 1	Homo sapiens	14-18
27488535-5	2016	Inhibition of HO-1 by tin protoporphyrin (SnPP) or siRNA downregulated Pax3/7-FoxO1 target genes and induced a myogenic program in RMS.	tin protoporphyrin IX	22-40	paired box 3	Homo sapiens	71-75
27553177-4	2016	This antiviral effect of HO-1 was attenuated by its inhibitor tin protoporphyrin (SnPP), suggesting that HO-1 was an important cellular factor against DENV replication.	tin protoporphyrin IX	62-80	heme oxygenase 1	Mus musculus	105-109
27548124-7	2016	Treatment with tin protoporphyrin, an inhibitor of HO-1, reversed the RAME-induced suppression of NO production.	tin protoporphyrin IX	15-33	heme oxygenase 1	Mus musculus	51-55
26670903-7	2015	The presence of SnPPIX significantly enhanced Cd-induced caspase 3 activities.	tin protoporphyrin IX	16-22	caspase 3	Homo sapiens	57-66
26730587-9	2016	Furthermore, the antinociceptive effects of morphine were enhanced by CoPP treatment and reversed by the administration of an HO-1 inhibitor, tin protoporphyrin IX (SnPP).	tin protoporphyrin IX	142-163	heme oxygenase 1	Mus musculus	126-130
25895145-7	2015	Tin protoporphyrin IX (TinPPIX), another HO-1 inhibitor, was also used in part for this study.	tin protoporphyrin IX	0-21	heme oxygenase 1	Mus musculus	41-45
26507166-12	2015	Tin protoporphyrin (SnPP)-IX, a HO-1 inhibitor, blocked the effect of hemin restoring MUC5AC protein secretion (p b 0.05) and goblet cell hyperplasia.	tin protoporphyrin IX	0-18	heme oxygenase 1	Homo sapiens	32-36
26507166-12	2015	Tin protoporphyrin (SnPP)-IX, a HO-1 inhibitor, blocked the effect of hemin restoring MUC5AC protein secretion (p b 0.05) and goblet cell hyperplasia.	tin protoporphyrin IX	0-18	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	86-92
26869829-8	2015	Cotreatment of GRo with tin protoporphyrin IX, a selective inhibitor of HO-1, not only inhibited upregulation of HO-1 induced by GRo, but also reversed the anti-inflammatory effect of GRo in LPS treated Raw 264.7 cells.	tin protoporphyrin IX	24-45	heme oxygenase 1	Mus musculus	72-76
26869829-8	2015	Cotreatment of GRo with tin protoporphyrin IX, a selective inhibitor of HO-1, not only inhibited upregulation of HO-1 induced by GRo, but also reversed the anti-inflammatory effect of GRo in LPS treated Raw 264.7 cells.	tin protoporphyrin IX	24-45	heme oxygenase 1	Mus musculus	113-117
25977183-5	2015	Both silencing the nuclear factor E2-related factor 2 (Nrf2) and the supplement of tin protoporphyrin IX (SnPP), a haeme oxygenase-1 (HO-1) inhibitor, cancelled the inhibitory effect of Z-lig on UVB-induced ROS upregulation in NHEKs.	tin protoporphyrin IX	83-104	heme oxygenase 1	Homo sapiens	115-139
26193830-4	2015	MATERIALS AND METHODS: Adult male Sprague-Dawley rats were randomized to receive I/R, I/R plus cepharanthine, or I/R plus cepharanthine plus the HO-1 activity inhibitor tin protoporphyrin (SnPP; n = 12 in each group).	tin protoporphyrin IX	169-187	heme oxygenase 1	Rattus norvegicus	145-149
25860295-6	2015	Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX.	tin protoporphyrin IX	94-101	fibrinogen beta chain	Homo sapiens	7-17
25860295-6	2015	Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX.	tin protoporphyrin IX	144-151	fibrinogen beta chain	Homo sapiens	7-17
25895145-14	2015	Zinc protoporphyrin IX and TinPPIX inhibited the expression of HO-1 protein.	tin protoporphyrin IX	27-34	heme oxygenase 1	Mus musculus	63-67
26329008-7	2015	Notably, tin protoporphyrin IX (SnPP), an inhibitor of HO-1, also attenuated TLR7-induced transcription of the TNF-alpha and IL-6 genes, suggesting that the effect of quercetin is mediated by HO-1.	tin protoporphyrin IX	9-30	toll-like receptor 7	Mus musculus	77-81
25744070-11	2015	Inhibition of HO-1 by tin protoporphyrin IX exacerbated autophagy and mitochondrial activity as well as cell viability in young cells.	tin protoporphyrin IX	22-43	heme oxygenase 1	Homo sapiens	14-18
25462643-11	2015	Moreover, the time dependence of HO-1 protein production for DHDMC was compared to its enzyme activity, which was further evaluated in the presence of lipopolysaccharide and the specific HO-1 inhibitor tin protoporphyrin IX.	tin protoporphyrin IX	202-223	heme oxygenase 1	Mus musculus	33-37
25462643-11	2015	Moreover, the time dependence of HO-1 protein production for DHDMC was compared to its enzyme activity, which was further evaluated in the presence of lipopolysaccharide and the specific HO-1 inhibitor tin protoporphyrin IX.	tin protoporphyrin IX	202-223	heme oxygenase 1	Mus musculus	187-191
25954969-10	2015	Inhibition of HO1 with tin protoporphyrin IX partially reversed the renoprotective effects of RSV.	tin protoporphyrin IX	23-44	heme oxygenase 1	Mus musculus	14-17
25620054-5	2015	HO-1 expression and/or activity were inhibited by siRNA or tin protoporphyrin (Sn PPIX) and enhanced by an expression plasmid or cobalt protoporphyrin (CoPPIX).	tin protoporphyrin IX	59-77	heme oxygenase 1	Homo sapiens	0-4
25620054-5	2015	HO-1 expression and/or activity were inhibited by siRNA or tin protoporphyrin (Sn PPIX) and enhanced by an expression plasmid or cobalt protoporphyrin (CoPPIX).	tin protoporphyrin IX	79-86	heme oxygenase 1	Homo sapiens	0-4
25620054-7	2015	Inhibition of HO-1 enzymatic activity with SnPPIX and silencing of the HO-1 gene by siRNA enhanced DEP-induced ROS production, further decreased cell viability and increased expression of inflammatory and cell adhesion molecules.	tin protoporphyrin IX	43-49	heme oxygenase 1	Homo sapiens	14-18
26329008-7	2015	Notably, tin protoporphyrin IX (SnPP), an inhibitor of HO-1, also attenuated TLR7-induced transcription of the TNF-alpha and IL-6 genes, suggesting that the effect of quercetin is mediated by HO-1.	tin protoporphyrin IX	9-30	tumor necrosis factor	Mus musculus	111-120
26329008-7	2015	Notably, tin protoporphyrin IX (SnPP), an inhibitor of HO-1, also attenuated TLR7-induced transcription of the TNF-alpha and IL-6 genes, suggesting that the effect of quercetin is mediated by HO-1.	tin protoporphyrin IX	9-30	interleukin 6	Mus musculus	125-129
24968709-10	2014	HO-1 knockdown or treatment with the HO-1 inhibitor tin protoporphyrin (SnPPIX) reversed the protective role of EGCG, indicating an important role for HO-1.	tin protoporphyrin IX	52-70	heme oxygenase 1	Homo sapiens	37-41
25342030-10	2014	Recombinant human MFGE8 reduced oxidative stress and enhanced the expression of extracellular signal-regulated kinase, nuclear factor erythroid 2-related factor 2, and HO-1; and the effects were abolished by integrin beta3 siRNA and HO inhibitor SnPP IX.	tin protoporphyrin IX	246-253	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	18-23
25342030-10	2014	Recombinant human MFGE8 reduced oxidative stress and enhanced the expression of extracellular signal-regulated kinase, nuclear factor erythroid 2-related factor 2, and HO-1; and the effects were abolished by integrin beta3 siRNA and HO inhibitor SnPP IX.	tin protoporphyrin IX	246-253	integrin subunit beta 3	Homo sapiens	208-222
25402296-11	2014	Heme oxygenase-1 was inhibited with tin protoporphyrin IX.	tin protoporphyrin IX	36-57	heme oxygenase 1	Rattus norvegicus	0-16
25402296-17	2014	The inhibition of heme oxygenase-1 with tin protoporphyrin IX in rats or heme oxygenase-1-specific small interfering RNA in mice decreased ischemic preconditioning-induced autophagy and diminished the protective effects of ischemic preconditioning against ischemia/reperfusion injury.	tin protoporphyrin IX	40-61	heme oxygenase 1	Rattus norvegicus	18-34
24968709-10	2014	HO-1 knockdown or treatment with the HO-1 inhibitor tin protoporphyrin (SnPPIX) reversed the protective role of EGCG, indicating an important role for HO-1.	tin protoporphyrin IX	52-70	heme oxygenase 1	Homo sapiens	37-41
24968709-10	2014	HO-1 knockdown or treatment with the HO-1 inhibitor tin protoporphyrin (SnPPIX) reversed the protective role of EGCG, indicating an important role for HO-1.	tin protoporphyrin IX	72-78	heme oxygenase 1	Homo sapiens	37-41
24968709-10	2014	HO-1 knockdown or treatment with the HO-1 inhibitor tin protoporphyrin (SnPPIX) reversed the protective role of EGCG, indicating an important role for HO-1.	tin protoporphyrin IX	72-78	heme oxygenase 1	Homo sapiens	37-41
24434421-5	2014	These effects were abolished by pre-incubation of cells with concentrations of BTCC or PTCC that maximize HO-1 induction and were reversed by the inhibitor of heme oxygenase activity tin protoporphyrin IX (SnPPIX).	tin protoporphyrin IX	206-212	heme oxygenase 1	Rattus norvegicus	106-110
25091623-8	2014	Inhibition of HO-1 activity by treatment with tin protoporphyrin IX, a specific HO-1 inhibitor, abrogated the inhibitory effects of 3-DSC on the production of NO and IL-6 in LPS-stimulated RAW264.7 cells.	tin protoporphyrin IX	46-67	heme oxygenase 1	Mus musculus	14-18
25091623-8	2014	Inhibition of HO-1 activity by treatment with tin protoporphyrin IX, a specific HO-1 inhibitor, abrogated the inhibitory effects of 3-DSC on the production of NO and IL-6 in LPS-stimulated RAW264.7 cells.	tin protoporphyrin IX	46-67	heme oxygenase 1	Mus musculus	80-84
25091623-8	2014	Inhibition of HO-1 activity by treatment with tin protoporphyrin IX, a specific HO-1 inhibitor, abrogated the inhibitory effects of 3-DSC on the production of NO and IL-6 in LPS-stimulated RAW264.7 cells.	tin protoporphyrin IX	46-67	interleukin 6	Mus musculus	166-170
24860503-11	2014	Inhibition of HO-1 activity with tin protoporphyrin demonstrated HO-1 was not essential for the protection by wt-hFHC.	tin protoporphyrin IX	33-51	heme oxygenase 1	Mus musculus	14-18
24860503-11	2014	Inhibition of HO-1 activity with tin protoporphyrin demonstrated HO-1 was not essential for the protection by wt-hFHC.	tin protoporphyrin IX	33-51	heme oxygenase 1	Mus musculus	65-69
24473736-5	2014	In contrast, addition of Sn-protoporphyrin (SnPP) to inhibit HSP32 expression completely reversed its hepatoprotective effect.	tin protoporphyrin IX	25-42	heme oxygenase 1	Mus musculus	61-66
24473736-5	2014	In contrast, addition of Sn-protoporphyrin (SnPP) to inhibit HSP32 expression completely reversed its hepatoprotective effect.	tin protoporphyrin IX	44-48	heme oxygenase 1	Mus musculus	61-66
24337631-8	2014	Moreover, pretreatment of tin protoporphyrin IX (SnPP), a chemical inhibitor of HO-1, reversed the ability of isothamnetin to inhibit COX-2 expression.	tin protoporphyrin IX	26-47	heme oxygenase 1	Rattus norvegicus	80-84
24337631-8	2014	Moreover, pretreatment of tin protoporphyrin IX (SnPP), a chemical inhibitor of HO-1, reversed the ability of isothamnetin to inhibit COX-2 expression.	tin protoporphyrin IX	26-47	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	134-139
24478369-7	2014	Inhibition of HO-1 activity with tin protoporphyrin IX attenuated the protective effects of DHA.	tin protoporphyrin IX	33-54	heme oxygenase 1	Mus musculus	14-18
23441850-11	2013	In addition, inhibition of HO-1 activity by tin protoporphyrin IX blocked the inhibitory effect of isorhamnetin on IL-6 production.	tin protoporphyrin IX	44-65	interleukin 6	Mus musculus	115-119
24268287-3	2014	In this study, we show that higher HO1 expression in Tregs is associated with increased survival under hypoxic conditions and that HO1 inhibitor, tin protoporphyrin (SnPP), abrogates the survival benefits.	tin protoporphyrin IX	146-164	heme oxygenase 1	Mus musculus	131-134
23864430-5	2013	The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads.	tin protoporphyrin IX	45-52	fibrinogen beta chain	Homo sapiens	16-26
23311871-5	2013	This was associated with induction of HO-1 expression, an effect reversed by alpha-bungarotoxin and by tin-protoporphyrin IX.	tin protoporphyrin IX	103-124	heme oxygenase 1	Mus musculus	38-42
24097973-6	2013	HO-1 inducer hemin or HO-1 inhibitor tin protoporphyrin IX was injected intraperitoneally into ovalbumin-challenged DO11.10 mice.	tin protoporphyrin IX	37-58	heme oxygenase 1	Mus musculus	22-26
23908468-5	2013	The HO-1 inhibitor, tin protoporphyrin, blocked MP4CO protection, consistent with HO-1 involvement in the protection afforded by MP4CO.	tin protoporphyrin IX	20-38	heme oxygenase 1	Mus musculus	4-8
23864430-5	2013	The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads.	tin protoporphyrin IX	101-108	fibrinogen beta chain	Homo sapiens	16-26
23977989-5	2013	Curcumin suppressed TNF-alpha- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA.	tin protoporphyrin IX	130-151	tumor necrosis factor	Homo sapiens	20-29
23661026-8	2013	Knockdown of HO-1 in Smad7-overexpressed cardiac fibroblasts or cells pretreated with SnPP IX, a competitive inhibitor of HO-1 activity, resulted in increased productions of ROS and NADPH p47(phox), and abolished the inhibitory effects of Smad7 on MMP9 activity and collagen expression.	tin protoporphyrin IX	86-93	heme oxygenase 1	Homo sapiens	13-17
23661026-8	2013	Knockdown of HO-1 in Smad7-overexpressed cardiac fibroblasts or cells pretreated with SnPP IX, a competitive inhibitor of HO-1 activity, resulted in increased productions of ROS and NADPH p47(phox), and abolished the inhibitory effects of Smad7 on MMP9 activity and collagen expression.	tin protoporphyrin IX	86-93	SMAD family member 7	Homo sapiens	21-26
23661026-8	2013	Knockdown of HO-1 in Smad7-overexpressed cardiac fibroblasts or cells pretreated with SnPP IX, a competitive inhibitor of HO-1 activity, resulted in increased productions of ROS and NADPH p47(phox), and abolished the inhibitory effects of Smad7 on MMP9 activity and collagen expression.	tin protoporphyrin IX	86-93	heme oxygenase 1	Homo sapiens	122-126
23661026-8	2013	Knockdown of HO-1 in Smad7-overexpressed cardiac fibroblasts or cells pretreated with SnPP IX, a competitive inhibitor of HO-1 activity, resulted in increased productions of ROS and NADPH p47(phox), and abolished the inhibitory effects of Smad7 on MMP9 activity and collagen expression.	tin protoporphyrin IX	86-93	pleckstrin	Homo sapiens	188-191
23661026-8	2013	Knockdown of HO-1 in Smad7-overexpressed cardiac fibroblasts or cells pretreated with SnPP IX, a competitive inhibitor of HO-1 activity, resulted in increased productions of ROS and NADPH p47(phox), and abolished the inhibitory effects of Smad7 on MMP9 activity and collagen expression.	tin protoporphyrin IX	86-93	SMAD family member 7	Homo sapiens	239-244
23661026-8	2013	Knockdown of HO-1 in Smad7-overexpressed cardiac fibroblasts or cells pretreated with SnPP IX, a competitive inhibitor of HO-1 activity, resulted in increased productions of ROS and NADPH p47(phox), and abolished the inhibitory effects of Smad7 on MMP9 activity and collagen expression.	tin protoporphyrin IX	86-93	matrix metallopeptidase 9	Homo sapiens	248-252
23977989-5	2013	Curcumin suppressed TNF-alpha- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA.	tin protoporphyrin IX	130-151	intercellular adhesion molecule 1	Homo sapiens	39-45
23977989-5	2013	Curcumin suppressed TNF-alpha- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA.	tin protoporphyrin IX	130-151	heme oxygenase 1	Homo sapiens	184-188
23665328-6	2013	Treatment of cells with HO-1 inhibitor SnPP IX (tin protoporphyrin IX) attenuated the LPS-mediated responses, HIV-1 replication and secretion of MIP1alpha, MIP1beta, and LD78beta chemokines with little change in surface CCR-5 expression.	tin protoporphyrin IX	39-46	heme oxygenase 1	Homo sapiens	24-28
23665328-6	2013	Treatment of cells with HO-1 inhibitor SnPP IX (tin protoporphyrin IX) attenuated the LPS-mediated responses, HIV-1 replication and secretion of MIP1alpha, MIP1beta, and LD78beta chemokines with little change in surface CCR-5 expression.	tin protoporphyrin IX	39-46	C-C motif chemokine ligand 3	Homo sapiens	145-154
23665328-6	2013	Treatment of cells with HO-1 inhibitor SnPP IX (tin protoporphyrin IX) attenuated the LPS-mediated responses, HIV-1 replication and secretion of MIP1alpha, MIP1beta, and LD78beta chemokines with little change in surface CCR-5 expression.	tin protoporphyrin IX	39-46	C-C motif chemokine ligand 4	Homo sapiens	156-164
23665328-6	2013	Treatment of cells with HO-1 inhibitor SnPP IX (tin protoporphyrin IX) attenuated the LPS-mediated responses, HIV-1 replication and secretion of MIP1alpha, MIP1beta, and LD78beta chemokines with little change in surface CCR-5 expression.	tin protoporphyrin IX	39-46	C-C motif chemokine receptor 5	Homo sapiens	220-225
23665328-6	2013	Treatment of cells with HO-1 inhibitor SnPP IX (tin protoporphyrin IX) attenuated the LPS-mediated responses, HIV-1 replication and secretion of MIP1alpha, MIP1beta, and LD78beta chemokines with little change in surface CCR-5 expression.	tin protoporphyrin IX	48-69	heme oxygenase 1	Homo sapiens	24-28
23665328-6	2013	Treatment of cells with HO-1 inhibitor SnPP IX (tin protoporphyrin IX) attenuated the LPS-mediated responses, HIV-1 replication and secretion of MIP1alpha, MIP1beta, and LD78beta chemokines with little change in surface CCR-5 expression.	tin protoporphyrin IX	48-69	C-C motif chemokine ligand 3	Homo sapiens	145-154
23665328-6	2013	Treatment of cells with HO-1 inhibitor SnPP IX (tin protoporphyrin IX) attenuated the LPS-mediated responses, HIV-1 replication and secretion of MIP1alpha, MIP1beta, and LD78beta chemokines with little change in surface CCR-5 expression.	tin protoporphyrin IX	48-69	C-C motif chemokine ligand 4	Homo sapiens	156-164
23665328-6	2013	Treatment of cells with HO-1 inhibitor SnPP IX (tin protoporphyrin IX) attenuated the LPS-mediated responses, HIV-1 replication and secretion of MIP1alpha, MIP1beta, and LD78beta chemokines with little change in surface CCR-5 expression.	tin protoporphyrin IX	48-69	C-C motif chemokine receptor 5	Homo sapiens	220-225
23523860-5	2013	Consistent with these observations, tin protoporphyrin (SnPP), a well-established HO-1 inhibitor, was found to be much less cytotoxic than ZnPP, and docosahexaenoic acid (DHA), an HO-1 inducer, enhanced ZnPP"s cytotoxicity.	tin protoporphyrin IX	36-54	heme oxygenase 1	Homo sapiens	82-86
22769443-9	2013	Inhibition of HO-1 activity by tin protoporphyrin IX (SnPP) abolished the suppressive effect of kaempferol on NO production.	tin protoporphyrin IX	31-52	heme oxygenase 1	Mus musculus	14-18
23566812-5	2013	The effects of TMC on LPS-induced NO, PGE2, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta production were partially reversed by the HO inhibitor tin protoporphyrin (SnPP).	tin protoporphyrin IX	161-179	tumor necrosis factor	Mus musculus	44-77
23566812-5	2013	The effects of TMC on LPS-induced NO, PGE2, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta production were partially reversed by the HO inhibitor tin protoporphyrin (SnPP).	tin protoporphyrin IX	161-179	interleukin 1 beta	Mus musculus	83-105
23525626-9	2013	These inhibitory effects BL were almost completely abolished by CC and partly by tin protoporphyrin-IX, a competitive inhibitor of HO-1.	tin protoporphyrin IX	81-102	heme oxygenase 1	Homo sapiens	131-135
23088309-6	2013	Both an AMPK inhibitor (compound C) and a HO-1 activity inhibitor (SnPPIX) but not inhibitors of MAPKs, PI3K and PKC reduced the production of VEGF by CKD712.	tin protoporphyrin IX	67-73	vascular endothelial growth factor A	Mus musculus	143-147
23429283-5	2013	The protection of xyloketal B against angiotensin II-induced apoptosis and reactive oxygen species (ROS) production could be abrogated by the HO-1 specific inhibitor, tin protoporphyrin-IX (SnPP).	tin protoporphyrin IX	167-188	heme oxygenase 1a	Danio rerio	142-146
23333396-9	2013	Moreover, a selective HO-1 inhibitor, tin protoporphyrin IX (SnPP), significantly blocked the anti-ischemic effect of LMT-335.	tin protoporphyrin IX	38-59	heme oxygenase 1	Rattus norvegicus	22-26
23573137-7	2013	However, blocking HO-1 activity by tin protoporphyrin IX (SnPP), an HO-1 inhibitor, markedly abolished these beneficial effects of ALA in LPS-induced ALI.	tin protoporphyrin IX	35-56	heme oxygenase 1	Homo sapiens	18-22
23573137-7	2013	However, blocking HO-1 activity by tin protoporphyrin IX (SnPP), an HO-1 inhibitor, markedly abolished these beneficial effects of ALA in LPS-induced ALI.	tin protoporphyrin IX	35-56	heme oxygenase 1	Homo sapiens	68-72
22820842-4	2012	More importantly, we found that Tin-protoporphyrin (SnPP), a selective inhibitor of HO-1, could block the effect of simvastatin on inhibition of cell proliferation in response to serotonin and abolish simvastatin-induced p21(WAF1) expression.	tin protoporphyrin IX	32-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	221-224
22820842-4	2012	More importantly, we found that Tin-protoporphyrin (SnPP), a selective inhibitor of HO-1, could block the effect of simvastatin on inhibition of cell proliferation in response to serotonin and abolish simvastatin-induced p21(WAF1) expression.	tin protoporphyrin IX	32-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	225-229
22564506-11	2012	The effects of santamarin on LPS-induced NO, PGE(2), TNF-alpha, and IL-1beta production were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP).	tin protoporphyrin IX	135-153	tumor necrosis factor	Mus musculus	53-62
22564506-11	2012	The effects of santamarin on LPS-induced NO, PGE(2), TNF-alpha, and IL-1beta production were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP).	tin protoporphyrin IX	135-153	interleukin 1 beta	Mus musculus	68-76
22522044-11	2012	Treatment of infected animals with anti-oxidants alpha-lipoic acid and N-acetylcysteine and HO inhibitor stannous protoporphyrin (SnPPIX) showed only selective beneficial effects on HO-1 and COX-2 expression in the liver and spleen and serum levels of KC and MCP-1.	tin protoporphyrin IX	130-136	heme oxygenase 1	Mus musculus	182-186
22661086-9	2012	Treatment of IRAK-M(-/-) mice in vivo and IRAK-M(-/-) AECs in vitro with the heme oxygenase-1 inhibitor, tin protoporphyrin, substantially decreased survival and significantly reduced the number of live cells after hyperoxia exposure.	tin protoporphyrin IX	105-123	interleukin-1 receptor-associated kinase 3	Mus musculus	13-19
22661086-9	2012	Treatment of IRAK-M(-/-) mice in vivo and IRAK-M(-/-) AECs in vitro with the heme oxygenase-1 inhibitor, tin protoporphyrin, substantially decreased survival and significantly reduced the number of live cells after hyperoxia exposure.	tin protoporphyrin IX	105-123	interleukin-1 receptor-associated kinase 3	Mus musculus	42-48
22661086-9	2012	Treatment of IRAK-M(-/-) mice in vivo and IRAK-M(-/-) AECs in vitro with the heme oxygenase-1 inhibitor, tin protoporphyrin, substantially decreased survival and significantly reduced the number of live cells after hyperoxia exposure.	tin protoporphyrin IX	105-123	heme oxygenase 1	Mus musculus	77-93
22522044-11	2012	Treatment of infected animals with anti-oxidants alpha-lipoic acid and N-acetylcysteine and HO inhibitor stannous protoporphyrin (SnPPIX) showed only selective beneficial effects on HO-1 and COX-2 expression in the liver and spleen and serum levels of KC and MCP-1.	tin protoporphyrin IX	130-136	cytochrome c oxidase II, mitochondrial	Mus musculus	191-196
22522044-11	2012	Treatment of infected animals with anti-oxidants alpha-lipoic acid and N-acetylcysteine and HO inhibitor stannous protoporphyrin (SnPPIX) showed only selective beneficial effects on HO-1 and COX-2 expression in the liver and spleen and serum levels of KC and MCP-1.	tin protoporphyrin IX	130-136	chemokine (C-C motif) ligand 2	Mus musculus	259-264
22095827-8	2012	Treatment of the animals with tin protoporphyrin-IX, a global HO inhibitor, or HO-1 small interfering RNA to knock down carotid artery HO-1 attenuated the ability of niacin to inhibit vascular inflammation.	tin protoporphyrin IX	30-51	heme oxygenase 1	Homo sapiens	135-139
22461332-5	2012	The protection was abolished when the cultures were transfected with nuclear factor (erythroid-derived 2) like-2-shRNA or coincubated with tin protoporphyrin IX, a specific HO-1 inhibitor.	tin protoporphyrin IX	139-160	heme oxygenase 1	Rattus norvegicus	173-177
21514603-7	2012	Inversely, the administration of tin protoporphyrin IX (SnPPN), a specific inhibitor of HO-1, completely abolished the therapeutic effects of octreotide, indicating that the favorable effects of octreotide against intestinal I/R injury is predominantly dependent on the early induction of HO-1.	tin protoporphyrin IX	33-54	heme oxygenase 1	Rattus norvegicus	88-92
21514603-7	2012	Inversely, the administration of tin protoporphyrin IX (SnPPN), a specific inhibitor of HO-1, completely abolished the therapeutic effects of octreotide, indicating that the favorable effects of octreotide against intestinal I/R injury is predominantly dependent on the early induction of HO-1.	tin protoporphyrin IX	33-54	heme oxygenase 1	Rattus norvegicus	289-293
22718607-7	2012	After the induction of HO-1 by hemin, gut barrier failure and apoptosis were abrogated in the immature gut, while the inhibition of HO-1 by tin protoporphyrin IX significantly aggravated gut injury.	tin protoporphyrin IX	140-161	heme oxygenase 1	Rattus norvegicus	132-136
21275512-10	2011	The protective effects of CoPP were HO-1 dependent because the upregulation of HO-1 and the RGC protection were both abolished by the HO-1 inhibitor tin protoporphyrin (SnPP).	tin protoporphyrin IX	149-167	heme oxygenase 1	Rattus norvegicus	36-40
22879979-11	2012	Moreover, the inhibition of HO with SnPPIX unmasked the toxic effect of high glucose and revealed the protection conferred by HO-1.	tin protoporphyrin IX	36-42	heme oxygenase 1	Homo sapiens	126-130
22001321-11	2011	Inhibitor of HO-1 activity, tin protoporphyrin IX, further increased HA-mediated reactivation of HIV-1 "mini-virus" in Jurkat clones, and this effect was also inhibited by N-acetyl cysteine.	tin protoporphyrin IX	28-49	heme oxygenase 1	Homo sapiens	13-17
21910986-5	2011	Pretreatment with the HO-1 inhibitor, tin protoporphyrin (SnPP), attenuated the inhibitory activities of LA on LPS-induced inflammatory NO, PGE(2), IL-1beta, TNF-alpha, IL-6 and IL-12 production.	tin protoporphyrin IX	38-56	heme oxygenase 1	Homo sapiens	22-26
21910986-5	2011	Pretreatment with the HO-1 inhibitor, tin protoporphyrin (SnPP), attenuated the inhibitory activities of LA on LPS-induced inflammatory NO, PGE(2), IL-1beta, TNF-alpha, IL-6 and IL-12 production.	tin protoporphyrin IX	38-56	interleukin 1 beta	Homo sapiens	148-156
21910986-5	2011	Pretreatment with the HO-1 inhibitor, tin protoporphyrin (SnPP), attenuated the inhibitory activities of LA on LPS-induced inflammatory NO, PGE(2), IL-1beta, TNF-alpha, IL-6 and IL-12 production.	tin protoporphyrin IX	38-56	interleukin 6	Homo sapiens	169-173
21840424-10	2011	Additionally, treatment with tin-protoporphyrin (SnPP), a selective inhibitor of HO-1, reversed the alpha-iso-cubebenol-mediated inhibition of P. gingivalis LPS-induced pro-inflammatory cytokines.	tin protoporphyrin IX	29-47	heme oxygenase 1	Homo sapiens	81-85
21975817-5	2011	In addition, treatment with SnPP (tin protoporphyrin IX), a selective HO-1 inhibitor, counteracted the inhibitory effect of EG on nitrite production, suggesting that HO-1 is, at least in part, implicated in the inhibition of NO production induced by EG treatment.	tin protoporphyrin IX	34-55	heme oxygenase 1	Homo sapiens	70-74
21975817-5	2011	In addition, treatment with SnPP (tin protoporphyrin IX), a selective HO-1 inhibitor, counteracted the inhibitory effect of EG on nitrite production, suggesting that HO-1 is, at least in part, implicated in the inhibition of NO production induced by EG treatment.	tin protoporphyrin IX	34-55	heme oxygenase 1	Homo sapiens	166-170
20716121-5	2011	In HO-1 Tg hearts treated with 50 mumol/kg of tin protoporphyrin IX (SnPPIX), an HO enzyme inhibitor, abolished the post-ischemic cardiac recovery.	tin protoporphyrin IX	46-67	heme oxygenase 1	Mus musculus	3-7
20716121-5	2011	In HO-1 Tg hearts treated with 50 mumol/kg of tin protoporphyrin IX (SnPPIX), an HO enzyme inhibitor, abolished the post-ischemic cardiac recovery.	tin protoporphyrin IX	69-75	heme oxygenase 1	Mus musculus	3-7
20716121-6	2011	HO-1 related carbon monoxide (CO) production was detected in NTg, HO-1 Tg and HO-1 Tg + SnPPIX treated groups, and a substantial increase in CO production was observed in the HO-1 Tg hearts subjected to ischemia/reperfusion.	tin protoporphyrin IX	88-94	heme oxygenase 1	Mus musculus	0-4
20716121-7	2011	Moreover, in ischemia/reperfusion-induced tissue Na(+) and Ca(2+) gains were reduced in HO-1 Tg group in comparison with the NTg and HO-1 Tg + SnPPIX treated groups; furthermore K(+) loss was reduced in the HO-1 Tg group.	tin protoporphyrin IX	143-149	heme oxygenase 1	Mus musculus	88-92
21437926-9	2011	Pharmacological inhibition of HO-1 activity using tin protoporphyrin or knockdown of HO-1 prevents the induction of autophagic signaling in these models and results in increased hepatocellular injury, apoptosis, and death.	tin protoporphyrin IX	50-68	heme oxygenase 1	Mus musculus	30-34
21198546-5	2011	This protection was decreased by an inhibitor of HO-1 action, tin protoporphyrin.	tin protoporphyrin IX	62-80	heme oxygenase 1	Rattus norvegicus	49-53
21448202-12	2011	HO-2 selectivity was greatest for tin protoporphyrin.	tin protoporphyrin IX	34-52	heme oxygenase 2	Rattus norvegicus	0-4
21275512-10	2011	The protective effects of CoPP were HO-1 dependent because the upregulation of HO-1 and the RGC protection were both abolished by the HO-1 inhibitor tin protoporphyrin (SnPP).	tin protoporphyrin IX	149-167	heme oxygenase 1	Rattus norvegicus	79-83
21275512-10	2011	The protective effects of CoPP were HO-1 dependent because the upregulation of HO-1 and the RGC protection were both abolished by the HO-1 inhibitor tin protoporphyrin (SnPP).	tin protoporphyrin IX	149-167	heme oxygenase 1	Rattus norvegicus	79-83
21705844-9	2011	The effects of asperlin on the LPS-induced expression of iNOS and COX-2 and production of NO, PGE2, TNF-alpha, and IL-1beta were partially reversed by a HO-1 inhibitor, tin protoporphyrin.	tin protoporphyrin IX	169-187	nitric oxide synthase 2, inducible	Mus musculus	57-61
21037234-6	2011	Finally, activation of AMPK inhibited cytokine-mediated EC death, and this was prevented by the HO inhibitor tin protoporphyrin-IX or by silencing HO-1 expression.	tin protoporphyrin IX	109-130	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	23-27
21075647-9	2011	These potential benefits of simvastatin were all abolished by co-application of tin protoporphyrin-IX (SnPP), a specific heme oxygenase-1 (HO-1) inhibitor.	tin protoporphyrin IX	80-101	heme oxygenase 1	Rattus norvegicus	121-137
21075647-9	2011	These potential benefits of simvastatin were all abolished by co-application of tin protoporphyrin-IX (SnPP), a specific heme oxygenase-1 (HO-1) inhibitor.	tin protoporphyrin IX	80-101	heme oxygenase 1	Rattus norvegicus	139-143
20940016-6	2011	Tin protoporphyrin IX (SnPP), a heme oxygenase-1(HO-1) inhibitor, blocked the inhibitory effect of dipyridamole on lipopolysaccharide-induced COX-2 and MCP-1 expression.	tin protoporphyrin IX	0-21	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	142-147
20940016-6	2011	Tin protoporphyrin IX (SnPP), a heme oxygenase-1(HO-1) inhibitor, blocked the inhibitory effect of dipyridamole on lipopolysaccharide-induced COX-2 and MCP-1 expression.	tin protoporphyrin IX	0-21	C-C motif chemokine ligand 2	Rattus norvegicus	152-157
21131421-5	2011	A heme oxygenase-1 (HO-1) inhibitor, tin-protoporphyrin-IX, markedly increased fluid accumulation in toxin A-treated wild-type mice, indicating the protective roles of HO-1 in this situation.	tin protoporphyrin IX	37-58	heme oxygenase 1	Mus musculus	2-18
21131421-5	2011	A heme oxygenase-1 (HO-1) inhibitor, tin-protoporphyrin-IX, markedly increased fluid accumulation in toxin A-treated wild-type mice, indicating the protective roles of HO-1 in this situation.	tin protoporphyrin IX	37-58	heme oxygenase 1	Mus musculus	20-24
21131421-5	2011	A heme oxygenase-1 (HO-1) inhibitor, tin-protoporphyrin-IX, markedly increased fluid accumulation in toxin A-treated wild-type mice, indicating the protective roles of HO-1 in this situation.	tin protoporphyrin IX	37-58	heme oxygenase 1	Mus musculus	168-172
20807546-3	2010	Interestingly, pretreatment with tin-protoporphyrin IX, a specific inhibitor of HO, caused a reduction in basal Nrf2 activity and thus enhanced sensitivity to MeHg.	tin protoporphyrin IX	33-54	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
20599745-4	2010	Treatment of HaCaT cells with tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, reversed the suppressive effect of celastrol on IFN-gamma-induced protein and mRNA expression of ICAM-1.	tin protoporphyrin IX	30-51	heme oxygenase 1	Homo sapiens	84-88
20621084-6	2010	The cytoprotective effect of sappanchalcone was nullified by HO-1 inhibitor, Tin protoporphyrin (SnPP).	tin protoporphyrin IX	77-95	heme oxygenase 1	Homo sapiens	61-65
20599750-8	2010	Treatment of RGM-1 cells with an HO-1 inhibitor (tin-protoporphyrin), or HO-1 siRNA inhibited sofalcone-induced VEGF production, suggesting that the effect of sofalcone on VEGF expression is mediated by the HO-1 pathway.	tin protoporphyrin IX	49-67	vascular endothelial growth factor A	Rattus norvegicus	112-116
20447456-7	2010	The relevance of HO-1 in 2MeSADP-induced neuroprotection was further demonstrated by the evidence that HO-1 inhibition with tin protoporphyrin (SnPP) prevented protection against H(2)O(2)-induced oxidative stress and cell death.	tin protoporphyrin IX	124-142	heme oxygenase 1	Mus musculus	17-21
20447456-7	2010	The relevance of HO-1 in 2MeSADP-induced neuroprotection was further demonstrated by the evidence that HO-1 inhibition with tin protoporphyrin (SnPP) prevented protection against H(2)O(2)-induced oxidative stress and cell death.	tin protoporphyrin IX	124-142	heme oxygenase 1	Mus musculus	103-107
20599745-4	2010	Treatment of HaCaT cells with tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, reversed the suppressive effect of celastrol on IFN-gamma-induced protein and mRNA expression of ICAM-1.	tin protoporphyrin IX	30-51	interferon gamma	Homo sapiens	138-147
20599745-4	2010	Treatment of HaCaT cells with tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, reversed the suppressive effect of celastrol on IFN-gamma-induced protein and mRNA expression of ICAM-1.	tin protoporphyrin IX	30-51	intercellular adhesion molecule 1	Homo sapiens	187-193
20088848-6	2010	Treatment with tin protoporphyrin, a selective inhibitor of HO-1, reversed the inhibition of nitric oxide production by MBMC, suggesting that HO-1 induction mediates MBMC-mediated suppression of nitric oxide production.	tin protoporphyrin IX	15-33	heme oxygenase 1	Mus musculus	60-64
20088848-6	2010	Treatment with tin protoporphyrin, a selective inhibitor of HO-1, reversed the inhibition of nitric oxide production by MBMC, suggesting that HO-1 induction mediates MBMC-mediated suppression of nitric oxide production.	tin protoporphyrin IX	15-33	heme oxygenase 1	Mus musculus	142-146
20053955-8	2010	Treatment with tin protoporphyrin IX, an HO inhibitor, or transfection of HO-1 small interfering RNA abolished the inductive effect of CORM-2 on p21(Waf1/Cip1) and reversed the suppressive effect of CORM-2 on PSC growth.	tin protoporphyrin IX	15-36	KRAS proto-oncogene, GTPase	Rattus norvegicus	145-148
20336709-5	2010	Interestingly, the inhibitory effects of DLPC on LPS-induced iNOS expression and TNF-alpha production were reversed by tin protoporphyrin, a HO-1 inhibitor.	tin protoporphyrin IX	119-137	heme oxygenase 1, chloroplastic	Glycine max	141-145
20061555-8	2010	Specificity of HO-1 was confirmed by substantial reversal of LPS-induced viral replication by pretreatment of cells with SnPP IX, an inhibitor of HO-1 enzyme activity.	tin protoporphyrin IX	121-128	heme oxygenase 1	Homo sapiens	15-19
20061555-8	2010	Specificity of HO-1 was confirmed by substantial reversal of LPS-induced viral replication by pretreatment of cells with SnPP IX, an inhibitor of HO-1 enzyme activity.	tin protoporphyrin IX	121-128	heme oxygenase 1	Homo sapiens	146-150
20053955-8	2010	Treatment with tin protoporphyrin IX, an HO inhibitor, or transfection of HO-1 small interfering RNA abolished the inductive effect of CORM-2 on p21(Waf1/Cip1) and reversed the suppressive effect of CORM-2 on PSC growth.	tin protoporphyrin IX	15-36	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	149-153
20053955-8	2010	Treatment with tin protoporphyrin IX, an HO inhibitor, or transfection of HO-1 small interfering RNA abolished the inductive effect of CORM-2 on p21(Waf1/Cip1) and reversed the suppressive effect of CORM-2 on PSC growth.	tin protoporphyrin IX	15-36	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	154-158
19646271-8	2009	Systemic treatment of siRNA targeting rHO-1 reduced hepatic HO-1 expression and decreased the serum bilirubin levels in a time- and dose-dependent manner, and siRNA decreased the indirect bilirubin levels more effectively than Sn-protoporphyrin (SnPP), an HO-1 inhibitor.	tin protoporphyrin IX	246-250	heme oxygenase 1	Rattus norvegicus	38-43
19520142-8	2009	In contrast, inhibition of HO activity by administration of tin protoporphyrin IX (SnPP, a specific inhibitor of HO) abolished the neuroprotective effects of HO-1 induction.	tin protoporphyrin IX	60-81	heme oxygenase 1	Rattus norvegicus	158-162
20194885-9	2010	Conversely, we observed a significant reduction in the expression of vascular endothelial growth factor in nondiabetic and diabetic animals treated with tin protoporphyrin (SnPP, a heme oxygenase-1 enzyme inhibitor), even after Ad.Trx1 therapy.	tin protoporphyrin IX	153-171	heme oxygenase 1	Rattus norvegicus	181-197
20081544-11	2010	In contrast, inhibition of endogenous HO-1 by SnPP aggravated the colitis.	tin protoporphyrin IX	46-50	heme oxygenase 1	Mus musculus	38-42
19660867-6	2009	This effect was prevented by treatment with tin protoporphyrin (SnPP, an inhibitor of HO-1 activity) administered via intraplantar 5min before the test, suggesting a main role of HO-1.	tin protoporphyrin IX	44-62	heme oxygenase 1	Mus musculus	86-90
19660867-6	2009	This effect was prevented by treatment with tin protoporphyrin (SnPP, an inhibitor of HO-1 activity) administered via intraplantar 5min before the test, suggesting a main role of HO-1.	tin protoporphyrin IX	44-62	heme oxygenase 1	Mus musculus	179-183
19646271-8	2009	Systemic treatment of siRNA targeting rHO-1 reduced hepatic HO-1 expression and decreased the serum bilirubin levels in a time- and dose-dependent manner, and siRNA decreased the indirect bilirubin levels more effectively than Sn-protoporphyrin (SnPP), an HO-1 inhibitor.	tin protoporphyrin IX	246-250	heme oxygenase 1	Rattus norvegicus	39-43
19356721-5	2009	Pretreatment of cells with tin protoporphyrin (a HO-1 inhibitor) or hemoglobin (a carbon monoxide scavenging agent) reversed dipyridamole inhibition of osteopontin expression.	tin protoporphyrin IX	27-45	secreted phosphoprotein 1	Rattus norvegicus	152-163
19495412-4	2009	Inhibition of HO-1 by tin protoporphyrin-IX resulted in retardation of wound closure.	tin protoporphyrin IX	22-43	heme oxygenase 1	Mus musculus	14-18
19226281-10	2009	Promoters of eNOS and HO-1 (L-arginine and haemin) ameliorated the [NO]/[ONOO(-)] ratio while their inhibitors (L-NAME or tin-protoporphyrin) showed no improvement in these ratio.	tin protoporphyrin IX	122-140	heme oxygenase 1	Oryctolagus cuniculus	22-26
19239904-4	2009	The suppressive effect of sofalcone on NO production was attenuated by treatment with tin-protoporphyrin (SnPP), a heme-oxygenase (HO)-1 inhibitor.	tin protoporphyrin IX	86-104	heme oxygenase 1	Homo sapiens	115-136
19372106-4	2009	One group of rats received ketamine (70 mg/kg ip) or saline concurrently with either the HO-1 inhibitor tin protoporphyrin IX (50 micromol/kg ip) or saline.	tin protoporphyrin IX	104-125	heme oxygenase 1	Rattus norvegicus	89-93
19885007-7	2009	Aprotinin effects were reversed by pre-treatment with the HO-1 inhibitor, tin protoporphyrin IX (SnPPIX).	tin protoporphyrin IX	74-95	heme oxygenase 1	Rattus norvegicus	58-62
19885007-7	2009	Aprotinin effects were reversed by pre-treatment with the HO-1 inhibitor, tin protoporphyrin IX (SnPPIX).	tin protoporphyrin IX	97-103	heme oxygenase 1	Rattus norvegicus	58-62
18772364-11	2008	Tin protoporphyrin (10 micromol/kg sc), an HO-1 inhibitor, partially abrogated protection by EDHB against ALT release, necrosis, and mitochondrial depolarization.	tin protoporphyrin IX	0-18	heme oxygenase 1	Mus musculus	43-47
18341478-8	2008	SnP (tin protoporphyrin), an HO-1 inhibitor, counteracted the effects of Adv-HO-1.	tin protoporphyrin IX	5-23	heme oxygenase 1	Homo sapiens	29-33
18341478-8	2008	SnP (tin protoporphyrin), an HO-1 inhibitor, counteracted the effects of Adv-HO-1.	tin protoporphyrin IX	5-23	heme oxygenase 1	Homo sapiens	77-81
18809379-4	2008	Furthermore, SnPPIX, a HO-1 inhibitor, reversed the effects of NS-398 on PGE(2) production, suggesting that COX-2 activity can be affected by HO-1.	tin protoporphyrin IX	13-19	heme oxygenase 1	Homo sapiens	23-27
18809379-4	2008	Furthermore, SnPPIX, a HO-1 inhibitor, reversed the effects of NS-398 on PGE(2) production, suggesting that COX-2 activity can be affected by HO-1.	tin protoporphyrin IX	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
18809379-4	2008	Furthermore, SnPPIX, a HO-1 inhibitor, reversed the effects of NS-398 on PGE(2) production, suggesting that COX-2 activity can be affected by HO-1.	tin protoporphyrin IX	13-19	heme oxygenase 1	Homo sapiens	142-146
18772364-11	2008	Tin protoporphyrin (10 micromol/kg sc), an HO-1 inhibitor, partially abrogated protection by EDHB against ALT release, necrosis, and mitochondrial depolarization.	tin protoporphyrin IX	0-18	glutamic pyruvic transaminase, soluble	Mus musculus	106-109
18573251-6	2008	Inhibition of HO-1 activity using the HO-1 inhibitor tin protoporphyrin IX (SnPPIX), resulted in loss of cytoprotection.	tin protoporphyrin IX	53-74	heme oxygenase 1	Homo sapiens	14-18
18573251-6	2008	Inhibition of HO-1 activity using the HO-1 inhibitor tin protoporphyrin IX (SnPPIX), resulted in loss of cytoprotection.	tin protoporphyrin IX	53-74	heme oxygenase 1	Homo sapiens	38-42
18573251-6	2008	Inhibition of HO-1 activity using the HO-1 inhibitor tin protoporphyrin IX (SnPPIX), resulted in loss of cytoprotection.	tin protoporphyrin IX	76-82	heme oxygenase 1	Homo sapiens	14-18
18573251-6	2008	Inhibition of HO-1 activity using the HO-1 inhibitor tin protoporphyrin IX (SnPPIX), resulted in loss of cytoprotection.	tin protoporphyrin IX	76-82	heme oxygenase 1	Homo sapiens	38-42
18602978-7	2008	Treatment with tin protoporphyrin IX (SnPP), an inhibitor of the catalytic activity of HO, significantly abolished the suppressive effect of Sasim on LPS-induced TNF-a production in THP-1/M cells.	tin protoporphyrin IX	15-36	tumor necrosis factor	Homo sapiens	162-167
18602978-7	2008	Treatment with tin protoporphyrin IX (SnPP), an inhibitor of the catalytic activity of HO, significantly abolished the suppressive effect of Sasim on LPS-induced TNF-a production in THP-1/M cells.	tin protoporphyrin IX	15-36	GLI family zinc finger 2	Homo sapiens	182-187
18323531-9	2008	Inhibition of HO activity with tin protoporphyrin-IX abolished the survival benefits of cav-1(-/-) cells and cav-1(-/-) mice exposed to hyperoxia.	tin protoporphyrin IX	31-52	caveolin 1, caveolae protein	Mus musculus	88-93
18323531-9	2008	Inhibition of HO activity with tin protoporphyrin-IX abolished the survival benefits of cav-1(-/-) cells and cav-1(-/-) mice exposed to hyperoxia.	tin protoporphyrin IX	31-52	caveolin 1, caveolae protein	Mus musculus	109-114
18569078-5	2008	Ear swelling induced by DNFB challenge was significantly reduced by topical treatment with cobalt protoporphyrin IX (CoPP), a HO-1 inducer, but exaggerated by blockage of HO-1 activity with tin protoporphyrin IX (SnPP), a HO-1 inhibitor.	tin protoporphyrin IX	190-211	heme oxygenase 1	Mus musculus	171-175
17964723-4	2008	The effect of CoPP was prevented by treatment with tin protoporphyrin (SnPP, an inhibitor of HO-1 activity) administered either by i.p.	tin protoporphyrin IX	51-69	heme oxygenase 1	Mus musculus	93-97
18426999-7	2008	Treatment of Bach1(-/-) mice with tin-protoporphyrin, an inhibitor of HO, abolished the antihypertrophic and antiremodeling effects of Bach1 gene ablation.	tin protoporphyrin IX	34-52	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	13-18
18426999-7	2008	Treatment of Bach1(-/-) mice with tin-protoporphyrin, an inhibitor of HO, abolished the antihypertrophic and antiremodeling effects of Bach1 gene ablation.	tin protoporphyrin IX	34-52	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	135-140
18563666-5	2008	Using the chemical inhibitor tin protoporphyrin, we also found that the inhibitory action of ISL on PDGF-induced proliferation is mediated by HO-1.	tin protoporphyrin IX	29-47	heme oxygenase 1	Rattus norvegicus	142-146
18344023-3	2008	Tin-protoporphyrin (SnPP) markedly inhibited the transforming growth factor beta1 (TGFbeta1)-induced expression of PAI-1 protein.	tin protoporphyrin IX	0-18	transforming growth factor beta 1	Homo sapiens	49-81
18344023-3	2008	Tin-protoporphyrin (SnPP) markedly inhibited the transforming growth factor beta1 (TGFbeta1)-induced expression of PAI-1 protein.	tin protoporphyrin IX	0-18	transforming growth factor beta 1	Homo sapiens	83-91
18344023-3	2008	Tin-protoporphyrin (SnPP) markedly inhibited the transforming growth factor beta1 (TGFbeta1)-induced expression of PAI-1 protein.	tin protoporphyrin IX	0-18	serpin family E member 1	Homo sapiens	115-120
18293301-8	2008	Application of SnPPIX, a HO-1 inhibitor, decreased the viability of HCC-1.2 cells, indicating the protective role of HO-1 induction.	tin protoporphyrin IX	15-21	heme oxygenase 1	Homo sapiens	25-29
18293301-8	2008	Application of SnPPIX, a HO-1 inhibitor, decreased the viability of HCC-1.2 cells, indicating the protective role of HO-1 induction.	tin protoporphyrin IX	15-21	C-C motif chemokine ligand 14	Homo sapiens	68-73
18293301-8	2008	Application of SnPPIX, a HO-1 inhibitor, decreased the viability of HCC-1.2 cells, indicating the protective role of HO-1 induction.	tin protoporphyrin IX	15-21	heme oxygenase 1	Homo sapiens	117-121
18505586-5	2008	S-methionyl-L-thiocitrulline (SMTC), and tin protoporphyrin (SnPP) were used to inhibit neuronal/constitutive NOS-1 and heme-oxygenase, respectively, and alter NO and CO production, respectively, as assessed by paired t-tests.	tin protoporphyrin IX	41-59	nitric oxide synthase 1, neuronal	Mus musculus	110-115
18633191-8	2008	The effects of Bach1 ablation on the plaque area and 8-iso-PG F2alpha excretion were almost completely abolished by treating DKO mice with Sn protoporphyrin, an inhibitor of HO activity.	tin protoporphyrin IX	139-156	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	15-20
18252008-6	2008	Cobalt protoporphyrin or tin protoporphyrin was injected during this period to induce or inhibit HO-1 activity, respectively.	tin protoporphyrin IX	25-43	heme oxygenase 1	Mus musculus	97-101
18569078-5	2008	Ear swelling induced by DNFB challenge was significantly reduced by topical treatment with cobalt protoporphyrin IX (CoPP), a HO-1 inducer, but exaggerated by blockage of HO-1 activity with tin protoporphyrin IX (SnPP), a HO-1 inhibitor.	tin protoporphyrin IX	190-211	heme oxygenase 1	Mus musculus	171-175
17603281-6	2007	Inhibition of VSMC growth and expression of p21(WAF1/CIP1) by curcumin were partially, but not completely, abolished when the cells were co- incubated with the HO inhibitor tin protoporphyrin.	tin protoporphyrin IX	173-191	KRAS proto-oncogene, GTPase	Rattus norvegicus	44-47
17982681-6	2007	Diminishing HO-1 activity by the HO-1 inhibitor tin protoporphyrin IX (SnPPIX) significantly enhanced the formation of PPIX up to 1.8 fold.	tin protoporphyrin IX	48-69	heme oxygenase 1	Homo sapiens	12-16
17982681-6	2007	Diminishing HO-1 activity by the HO-1 inhibitor tin protoporphyrin IX (SnPPIX) significantly enhanced the formation of PPIX up to 1.8 fold.	tin protoporphyrin IX	48-69	heme oxygenase 1	Homo sapiens	33-37
17982681-6	2007	Diminishing HO-1 activity by the HO-1 inhibitor tin protoporphyrin IX (SnPPIX) significantly enhanced the formation of PPIX up to 1.8 fold.	tin protoporphyrin IX	71-77	heme oxygenase 1	Homo sapiens	12-16
17982681-6	2007	Diminishing HO-1 activity by the HO-1 inhibitor tin protoporphyrin IX (SnPPIX) significantly enhanced the formation of PPIX up to 1.8 fold.	tin protoporphyrin IX	71-77	heme oxygenase 1	Homo sapiens	33-37
17982681-9	2007	The pharmacological inhibition of HO-1 activity by SnPPIX leads to a considerable increase in the sensitivity of tumor cells to ALA-PDT treatment.	tin protoporphyrin IX	51-57	heme oxygenase 1	Homo sapiens	34-38
17881360-9	2007	Likewise, inhibition of HO-1 activity by chronic administration of the HO-1 inhibitor tin protoporphyrin IX to mice reduces RhoAQL-induced tumor growth by 70%.	tin protoporphyrin IX	86-107	heme oxygenase 1	Mus musculus	24-28
17881360-9	2007	Likewise, inhibition of HO-1 activity by chronic administration of the HO-1 inhibitor tin protoporphyrin IX to mice reduces RhoAQL-induced tumor growth by 70%.	tin protoporphyrin IX	86-107	heme oxygenase 1	Homo sapiens	71-75
17679649-5	2007	The increase in HO-1 activity and inhibition of NADPH oxidase activity by hemin were reversed by tin protoporphyrin-IX and were not associated with changes in Nox2 or Nox4 protein levels.	tin protoporphyrin IX	97-118	heme oxygenase 1	Homo sapiens	16-20
17991714-9	2007	This protective effect was specifically blocked by Sn-protoporphyrin, a HO-1 enzymatic inhibitor.	tin protoporphyrin IX	51-68	heme oxygenase 1	Mus musculus	72-76
18210237-8	2007	The inhibitory effects of costunolide on TNF-alpha and IL-6 production were abrogated by tin protoporphyrin, an HO inhibitor.	tin protoporphyrin IX	89-107	tumor necrosis factor	Homo sapiens	41-50
18210237-8	2007	The inhibitory effects of costunolide on TNF-alpha and IL-6 production were abrogated by tin protoporphyrin, an HO inhibitor.	tin protoporphyrin IX	89-107	interleukin 6	Homo sapiens	55-59
17673672-10	2007	In vitro analysis revealed that IL-10 significantly inhibited excessive proliferation of cultured human PA smooth muscle cells treated with transforming growth factor-beta1 or the heme oxygenase inhibitor tin protoporphyrin IX.	tin protoporphyrin IX	205-226	interleukin 10	Homo sapiens	32-37
17603281-6	2007	Inhibition of VSMC growth and expression of p21(WAF1/CIP1) by curcumin were partially, but not completely, abolished when the cells were co- incubated with the HO inhibitor tin protoporphyrin.	tin protoporphyrin IX	173-191	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	48-52
17603281-6	2007	Inhibition of VSMC growth and expression of p21(WAF1/CIP1) by curcumin were partially, but not completely, abolished when the cells were co- incubated with the HO inhibitor tin protoporphyrin.	tin protoporphyrin IX	173-191	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	53-57
17437850-9	2007	In addition, the protective effects of hemin were significantly offset by the heme oxygenase-1 inhibitor tin protoporphyrin.	tin protoporphyrin IX	105-123	heme oxygenase 1	Rattus norvegicus	78-94
17275847-5	2007	When animals were pretreated with hemin for augmentation of HO-1 expression, CCl(4)-exposure was associated with a reduction of intrahepatic leukocyte accumulation, while inhibition of CCl(4)-induced HO-1 expression by tin protoporphyrin-IX (SnPP-IX) enhanced leukocytic response.	tin protoporphyrin IX	219-240	heme oxygenase 1	Homo sapiens	60-64
17275847-5	2007	When animals were pretreated with hemin for augmentation of HO-1 expression, CCl(4)-exposure was associated with a reduction of intrahepatic leukocyte accumulation, while inhibition of CCl(4)-induced HO-1 expression by tin protoporphyrin-IX (SnPP-IX) enhanced leukocytic response.	tin protoporphyrin IX	219-240	heme oxygenase 1	Homo sapiens	200-204
17275847-5	2007	When animals were pretreated with hemin for augmentation of HO-1 expression, CCl(4)-exposure was associated with a reduction of intrahepatic leukocyte accumulation, while inhibition of CCl(4)-induced HO-1 expression by tin protoporphyrin-IX (SnPP-IX) enhanced leukocytic response.	tin protoporphyrin IX	242-249	heme oxygenase 1	Homo sapiens	60-64
17275847-5	2007	When animals were pretreated with hemin for augmentation of HO-1 expression, CCl(4)-exposure was associated with a reduction of intrahepatic leukocyte accumulation, while inhibition of CCl(4)-induced HO-1 expression by tin protoporphyrin-IX (SnPP-IX) enhanced leukocytic response.	tin protoporphyrin IX	242-249	heme oxygenase 1	Homo sapiens	200-204
16826603-5	2006	Ang II elicited apoptosis was augmented in the presence of tin protoporphyrin, an inhibitor of HO activity, while HO-1 gene transfer to myocytes attenuated Ang II-mediated apoptosis but not hypertrophy.	tin protoporphyrin IX	59-77	angiotensinogen	Rattus norvegicus	0-6
17018578-5	2007	MGd used in combination with tin protoporphyrin IX, an inhibitor of HO1, resulted in synergistic cell killing.	tin protoporphyrin IX	29-50	heme oxygenase 1	Homo sapiens	68-71
16982036-7	2006	Using the chemical inhibitor tin protoporphyrin, we also found that the inhibitory action of TMMC on PDGF-induced proliferation is mediated by HO-1.	tin protoporphyrin IX	29-47	heme oxygenase 1	Rattus norvegicus	143-147
17292349-8	2007	In contrast, the HO-1 inhibitor, zinc protoporphyrin (50 micromol/kg/day, s.c) significantly increased the colonic damage and myeloperoxidase activity over 10 days, as did tin protoporphyrin (30 micromol/kg/day, s.c).	tin protoporphyrin IX	172-190	heme oxygenase 1	Rattus norvegicus	17-21
16950787-5	2006	HO-1 inhibition with tin-protoporphyrin IX and silencing with RNA interference rendered cells more sensitive to apoptosis induction by EGCG and classical prooxidants.	tin protoporphyrin IX	21-42	heme oxygenase 1	Homo sapiens	0-4
16849502-7	2006	Inhibition of p38alpha no longer occurred when HO activity was inhibited by tin protoporphyrin IX, suggesting that p38alpha degradation was mediated by an end product of heme catabolism.	tin protoporphyrin IX	76-97	mitogen-activated protein kinase 14	Homo sapiens	14-22
16327497-4	2005	In additional heat-preconditioned animals (n = 8), HSP-32 was inhibited by tin-protoporphyrin-IX.	tin protoporphyrin IX	75-96	heme oxygenase 1	Mus musculus	51-57
16476737-5	2006	Moreover, targeted knock-down gene expression of HO-1 by small hairpin RNA and chemical inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPP), impaired vGPCR-induced survival, proliferation, transformation, and vascular endothelial growth factor (VEGF)-A expression.	tin protoporphyrin IX	129-150	heme oxygenase 1	Homo sapiens	102-106
16552707-8	2006	An HO-1 inhibitor, tin-protoporphyrin-IX, significantly increased APAP-induced mortality, implicating HO-1 as a protective molecule for APAP-induced liver injury.	tin protoporphyrin IX	19-40	heme oxygenase 1	Mus musculus	3-7
16552707-8	2006	An HO-1 inhibitor, tin-protoporphyrin-IX, significantly increased APAP-induced mortality, implicating HO-1 as a protective molecule for APAP-induced liver injury.	tin protoporphyrin IX	19-40	heme oxygenase 1	Mus musculus	102-106
16545694-5	2006	The involvement of HO-1 in VEGF synthesis was confirmed by inhibition of VEGF expression by SnPPIX, a blocker of HO activity and by attenuation of HO-1 mRNA expression with specific siRNA.	tin protoporphyrin IX	92-98	heme oxygenase 1	Homo sapiens	19-23
16545694-5	2006	The involvement of HO-1 in VEGF synthesis was confirmed by inhibition of VEGF expression by SnPPIX, a blocker of HO activity and by attenuation of HO-1 mRNA expression with specific siRNA.	tin protoporphyrin IX	92-98	vascular endothelial growth factor A	Homo sapiens	27-31
16545694-5	2006	The involvement of HO-1 in VEGF synthesis was confirmed by inhibition of VEGF expression by SnPPIX, a blocker of HO activity and by attenuation of HO-1 mRNA expression with specific siRNA.	tin protoporphyrin IX	92-98	vascular endothelial growth factor A	Homo sapiens	73-77
16547262-7	2006	Suppression of HIV replication in hemin-activated cells correlated with the induction of HO-1 and was attenuated by tin protoporphyrin (SnPP) IX, an inhibitor of HO-1 activity, suggesting a pivotal role of this endogenous enzyme in the regulation of HIV infection.	tin protoporphyrin IX	116-134	heme oxygenase 1	Homo sapiens	162-166
16327497-11	2005	Most strikingly, inhibition of HSP-32 by tin-protoporphyrin-IX completely blunted the preconditioning-induced improvement of microcirculation and resulted in manifestation of 72% +/- 4% necrosis.	tin protoporphyrin IX	41-62	heme oxygenase 1	Mus musculus	31-37
16198371-5	2005	This angiogenic response was repressed by tin-protoporphyrin IX (SnPP), an HO-1 inhibitor, along with downregulation of VEGF expression.	tin protoporphyrin IX	42-63	heme oxygenase 1	Rattus norvegicus	75-79
16395656-5	2005	The HO-1 inducer hemin is associated with the suppression of LPS-induced NO production in a dose-dependent manner, and the HO-1 inhibitor tin protoporphyrin attenuates the inhibitory activity of PPD on LPS-induced NO production.	tin protoporphyrin IX	138-156	heme oxygenase 1	Mus musculus	123-127
15901601-8	2005	This inhibitory effect of the analog is modulated by HO-1 because it was blocked by SnPPIX, a competitive inhibitor that blocks HO-1 activity.	tin protoporphyrin IX	84-90	heme oxygenase 1	Homo sapiens	53-57
16309584-5	2005	Inhibition of HO activity by SnPPIX decreased VEGF production, while, interestingly, it did not affect IL-8.	tin protoporphyrin IX	29-35	vascular endothelial growth factor A	Homo sapiens	46-50
15901601-8	2005	This inhibitory effect of the analog is modulated by HO-1 because it was blocked by SnPPIX, a competitive inhibitor that blocks HO-1 activity.	tin protoporphyrin IX	84-90	heme oxygenase 1	Homo sapiens	128-132
15911218-8	2005	AZD3582-induced blockade of free-radical formation was reversed in the presence of the HO-1 inhibitor, tin protoporphyrin-IX (SnPP).	tin protoporphyrin IX	103-124	heme oxygenase 1	Homo sapiens	87-91
15996225-7	2005	In contrast, tin protoporphyrin-mediated HO-1 inhibition restored hepatic damage in otherwise IRI-resistant TLR4 mutant/KO mice.	tin protoporphyrin IX	13-31	heme oxygenase 1	Mus musculus	41-45
15996225-7	2005	In contrast, tin protoporphyrin-mediated HO-1 inhibition restored hepatic damage in otherwise IRI-resistant TLR4 mutant/KO mice.	tin protoporphyrin IX	13-31	toll-like receptor 4	Mus musculus	108-112
15689417-8	2005	Furthermore, using tin protoporphyrin IX (SnPP) and anti-MCP-1 antibody to abolish iAs-induced HO-1 and MCP-1 activity, respectively, shows that HO-1 has protective effect against iAs-induced injury in VSMCs and MCP-1 is chemoattractive to human monocytes, THP-1.	tin protoporphyrin IX	19-40	heme oxygenase 1	Homo sapiens	95-99
15689417-8	2005	Furthermore, using tin protoporphyrin IX (SnPP) and anti-MCP-1 antibody to abolish iAs-induced HO-1 and MCP-1 activity, respectively, shows that HO-1 has protective effect against iAs-induced injury in VSMCs and MCP-1 is chemoattractive to human monocytes, THP-1.	tin protoporphyrin IX	19-40	C-C motif chemokine ligand 2	Homo sapiens	104-109
15689417-8	2005	Furthermore, using tin protoporphyrin IX (SnPP) and anti-MCP-1 antibody to abolish iAs-induced HO-1 and MCP-1 activity, respectively, shows that HO-1 has protective effect against iAs-induced injury in VSMCs and MCP-1 is chemoattractive to human monocytes, THP-1.	tin protoporphyrin IX	19-40	heme oxygenase 1	Homo sapiens	145-149
15689417-8	2005	Furthermore, using tin protoporphyrin IX (SnPP) and anti-MCP-1 antibody to abolish iAs-induced HO-1 and MCP-1 activity, respectively, shows that HO-1 has protective effect against iAs-induced injury in VSMCs and MCP-1 is chemoattractive to human monocytes, THP-1.	tin protoporphyrin IX	19-40	C-C motif chemokine ligand 2	Homo sapiens	104-109
15226216-5	2004	Cotreatment of cells with tin protoporphyrin IX, a HO inhibitor, significantly reversed the suppressive effect of HO-1.	tin protoporphyrin IX	26-47	heme oxygenase 1	Rattus norvegicus	114-118
15543205-4	2005	Therapeutic administration of the HO-1 inhibitor tin protoporphyrin IX was able to control the symptoms of arthritis.	tin protoporphyrin IX	49-70	heme oxygenase 1	Rattus norvegicus	34-38
15596152-4	2005	Inhibition of HO-1 activity by tin protoporphyrin (SnPPIX) resulted in downregulation of VEGF synthesis in murine fibroblasts and human keratinocytes.	tin protoporphyrin IX	31-49	heme oxygenase 1	Mus musculus	14-18
15596152-4	2005	Inhibition of HO-1 activity by tin protoporphyrin (SnPPIX) resulted in downregulation of VEGF synthesis in murine fibroblasts and human keratinocytes.	tin protoporphyrin IX	31-49	vascular endothelial growth factor A	Mus musculus	89-93
15596152-4	2005	Inhibition of HO-1 activity by tin protoporphyrin (SnPPIX) resulted in downregulation of VEGF synthesis in murine fibroblasts and human keratinocytes.	tin protoporphyrin IX	51-57	heme oxygenase 1	Mus musculus	14-18
15596152-4	2005	Inhibition of HO-1 activity by tin protoporphyrin (SnPPIX) resulted in downregulation of VEGF synthesis in murine fibroblasts and human keratinocytes.	tin protoporphyrin IX	51-57	vascular endothelial growth factor A	Mus musculus	89-93
15220209-9	2004	Tin-protoporphyrin IX (HO-1 inhibitor) partially reversed the cadmium chloride-mediated downregulation of iNOS expression.	tin protoporphyrin IX	0-21	heme oxygenase 1	Mus musculus	23-27
15220209-9	2004	Tin-protoporphyrin IX (HO-1 inhibitor) partially reversed the cadmium chloride-mediated downregulation of iNOS expression.	tin protoporphyrin IX	0-21	nitric oxide synthase 2, inducible	Mus musculus	106-110
12969148-10	2003	Tin protoporphyrin (SnPP), an inhibitor of HO function, significantly reversed the cytoprotection by HO-1.	tin protoporphyrin IX	0-18	heme oxygenase 1	Homo sapiens	101-105
14512878-5	2003	In addition, overexpression of HO-1 by adenoviral gene transfer resulted in protection from apoptotic liver injury, whereas inhibition of HO-1 enzymatic activity by tin-protoporphyrin-IX (SnPP) abrogated the protective effect.	tin protoporphyrin IX	165-186	heme oxygenase 1	Mus musculus	138-142
14662543-10	2003	Blockade of HO in vivo with tin protoporphyrin IX abolished the sex differences caused by diverse HO1 expression.	tin protoporphyrin IX	28-49	heme oxygenase 1	Rattus norvegicus	98-101
14563492-7	2003	Pretreatment of the HO-1 inhibitor, tin protoporphyrin (10 microM), attenuated the inhibitory activities of the indicated flavonoids on LPS-induced NO production.	tin protoporphyrin IX	36-54	heme oxygenase 1	Mus musculus	20-24
14563492-7	2003	Pretreatment of the HO-1 inhibitor, tin protoporphyrin (10 microM), attenuated the inhibitory activities of the indicated flavonoids on LPS-induced NO production.	tin protoporphyrin IX	36-54	toll-like receptor 4	Mus musculus	136-139
12919086-5	2003	However, inhibition of HO-1 with tin protoporphyrin reversed cytoprotective/antiapoptotic effects of IL-13.	tin protoporphyrin IX	33-51	heme oxygenase 1	Rattus norvegicus	23-27
12919086-5	2003	However, inhibition of HO-1 with tin protoporphyrin reversed cytoprotective/antiapoptotic effects of IL-13.	tin protoporphyrin IX	33-51	interleukin 13	Rattus norvegicus	101-106
12926842-2	2003	To investigate the role of HO-1 in EAE, a putative inhibitor [tin-protoporphyrin IX (Sn-PP IX)] of HO-1 was administered to SJL mice during active disease.	tin protoporphyrin IX	62-83	heme oxygenase 1	Mus musculus	99-103
12819870-2	2003	We investigated the protective role of HO-1, induced by tin-protoporphyrin IX (SnPP), in attenuating liver transplantation injury.	tin protoporphyrin IX	56-77	heme oxygenase 1	Rattus norvegicus	39-43
12646399-8	2003	This potentiation was inhibited by incubation with the HO inhibitor tin protoporphyrin IX, supporting a role for HO-1 in the potentiation of the cytotoxic response.	tin protoporphyrin IX	68-89	heme oxygenase 1	Homo sapiens	113-117
12709592-9	2003	The effect of a HO-1 enzyme activity inhibitor, tin protoporphyrin (SnPP), on Caco-2 cell proliferation and differentiation was examined.	tin protoporphyrin IX	48-66	heme oxygenase 1	Homo sapiens	16-20
12716475-4	2003	Here, we investigated the role of the HO pathway in the production and angiogenic activity of vascular endothelial growth factor (VEGF) in endothelial cells treated with SnPPIX, or cultured in the presence of a CO-releasing molecule (CO-RM).	tin protoporphyrin IX	170-176	vascular endothelial growth factor A	Homo sapiens	94-128
12716475-4	2003	Here, we investigated the role of the HO pathway in the production and angiogenic activity of vascular endothelial growth factor (VEGF) in endothelial cells treated with SnPPIX, or cultured in the presence of a CO-releasing molecule (CO-RM).	tin protoporphyrin IX	170-176	vascular endothelial growth factor A	Homo sapiens	130-134
12716475-7	2003	SnPPIX prevented the induction of CO generation and inhibited VEGF synthesis.	tin protoporphyrin IX	0-6	vascular endothelial growth factor A	Homo sapiens	62-66
12716475-8	2003	Moreover, SnPPIX reduced the VEGF-elicited angiogenic activities of endothelial cells by decreasing their proliferation (by 26%), migration (by 46%), formation of tubes on Matrigel (by 48%), and outgrowth of capillaries from endothelial spheroids (by 30%).	tin protoporphyrin IX	10-16	vascular endothelial growth factor A	Homo sapiens	29-33
12591764-9	2003	CONCLUSIONS: The induction of HO-1 expression by rapamycin and, more importantly, the effects of tin protoporphyrin, an inhibitor of HO activity, on the antiproliferative actions of rapamycin suggest that the effects of rapamycin may be, at least in part, modulated by its actions on HO-1.	tin protoporphyrin IX	97-115	heme oxygenase 1	Homo sapiens	284-288
12578834-5	2003	The relevance of HO-1 in NGF-induced ROS reduction was further demonstrated by the evidence that cells treated with the HO-1 inhibitor tin-protoporphyrin or infected with a retroviral expression vector for antisense HO-1 exhibited enhanced ROS release in response to 6-OHDA, despite the presence of the neurotrophin.	tin protoporphyrin IX	135-153	heme oxygenase 1	Homo sapiens	17-21
12578834-5	2003	The relevance of HO-1 in NGF-induced ROS reduction was further demonstrated by the evidence that cells treated with the HO-1 inhibitor tin-protoporphyrin or infected with a retroviral expression vector for antisense HO-1 exhibited enhanced ROS release in response to 6-OHDA, despite the presence of the neurotrophin.	tin protoporphyrin IX	135-153	nerve growth factor	Homo sapiens	25-28
12578834-5	2003	The relevance of HO-1 in NGF-induced ROS reduction was further demonstrated by the evidence that cells treated with the HO-1 inhibitor tin-protoporphyrin or infected with a retroviral expression vector for antisense HO-1 exhibited enhanced ROS release in response to 6-OHDA, despite the presence of the neurotrophin.	tin protoporphyrin IX	135-153	heme oxygenase 1	Rattus norvegicus	120-124
12578834-5	2003	The relevance of HO-1 in NGF-induced ROS reduction was further demonstrated by the evidence that cells treated with the HO-1 inhibitor tin-protoporphyrin or infected with a retroviral expression vector for antisense HO-1 exhibited enhanced ROS release in response to 6-OHDA, despite the presence of the neurotrophin.	tin protoporphyrin IX	135-153	heme oxygenase 1	Homo sapiens	120-124
12578834-5	2003	The relevance of HO-1 in NGF-induced ROS reduction was further demonstrated by the evidence that cells treated with the HO-1 inhibitor tin-protoporphyrin or infected with a retroviral expression vector for antisense HO-1 exhibited enhanced ROS release in response to 6-OHDA, despite the presence of the neurotrophin.	tin protoporphyrin IX	135-153	brain derived neurotrophic factor	Homo sapiens	303-315
12396617-6	2002	However, inhibition of HO-1 after treatment with tin protoporphyrin reversed the immunomodulatory/antiapoptotic effects of Ad-IL-13 both in vivo (infectious transplantation tolerance), and in vitro (HUVECs).	tin protoporphyrin IX	49-67	heme oxygenase 1	Homo sapiens	23-27
12673348-2	2003	Tin protoporphyrin (SnPPIX) and zinc protoporphyrin (ZnPPIX) are commonly used as competitive inhibitors of HO-1.	tin protoporphyrin IX	0-18	heme oxygenase 1	Mus musculus	108-112
12673348-2	2003	Tin protoporphyrin (SnPPIX) and zinc protoporphyrin (ZnPPIX) are commonly used as competitive inhibitors of HO-1.	tin protoporphyrin IX	20-26	heme oxygenase 1	Mus musculus	108-112
12673348-3	2003	We aimed to compare the effects of SnPPIX and ZnPPIX on the production of vascular endothelial growth factor (VEGF), activity of inducible nitric oxide synthase (iNOS) and cell viability.	tin protoporphyrin IX	35-41	vascular endothelial growth factor A	Mus musculus	74-108
12673348-3	2003	We aimed to compare the effects of SnPPIX and ZnPPIX on the production of vascular endothelial growth factor (VEGF), activity of inducible nitric oxide synthase (iNOS) and cell viability.	tin protoporphyrin IX	35-41	vascular endothelial growth factor A	Mus musculus	110-114
12673348-6	2003	After a 24 h incubation period SnPPIX and ZnPPIX significantly reduced the generation of VEGF in vascular smooth muscle cells and RAW264.7, both in resting and stimulated cells.	tin protoporphyrin IX	31-37	vascular endothelial growth factor A	Mus musculus	89-93
12673348-9	2003	Generation of nitric oxide by iNOS was significantly increased by SnPPIX but strongly decreased by ZnPPIX.	tin protoporphyrin IX	66-72	nitric oxide synthase 2, inducible	Mus musculus	30-34
12673348-12	2003	In summary, SnPPIX and ZnPPIX can be used as HO-1 inhibitors in some experimental models.	tin protoporphyrin IX	12-18	heme oxygenase 1	Mus musculus	45-49
12396617-6	2002	However, inhibition of HO-1 after treatment with tin protoporphyrin reversed the immunomodulatory/antiapoptotic effects of Ad-IL-13 both in vivo (infectious transplantation tolerance), and in vitro (HUVECs).	tin protoporphyrin IX	49-67	interleukin 13	Homo sapiens	126-131
12230869-9	2002	Importantly, the inhibition of the HO-1 pathway by tin protoporphyrin-IX significantly reduced the stimulatory effect of 15d-PGJ(2) on VEGF synthesis.	tin protoporphyrin IX	51-72	heme oxygenase 1	Homo sapiens	35-39
12121889-6	2002	These effects were abolished by the heme-oxygenase-1 (HO-1) inhibitor tin protoporphyrin (Sn-PP).	tin protoporphyrin IX	70-88	heme oxygenase 1	Rattus norvegicus	36-52
12121889-6	2002	These effects were abolished by the heme-oxygenase-1 (HO-1) inhibitor tin protoporphyrin (Sn-PP).	tin protoporphyrin IX	70-88	heme oxygenase 1	Rattus norvegicus	54-58
12230869-9	2002	Importantly, the inhibition of the HO-1 pathway by tin protoporphyrin-IX significantly reduced the stimulatory effect of 15d-PGJ(2) on VEGF synthesis.	tin protoporphyrin IX	51-72	vascular endothelial growth factor A	Homo sapiens	135-139
12133272-7	2002	These beneficial effects were abrogated after adjunctive treatment with tin protoporphyrin (SnPP), an HO-1 antagonist.	tin protoporphyrin IX	72-90	heme oxygenase 1	Rattus norvegicus	102-106
12006174-5	2002	In contrast, inhibition of HO activity by tin protoporphyrin IX (SnPPIX) totally prevented cytokine-induced increase in VEGF, despite an augmented synthesis of intracellular NO.	tin protoporphyrin IX	42-63	vascular endothelial growth factor A	Rattus norvegicus	120-124
11981758-6	2002	HO-1 was specifically induced and inhibited by cobalt protoporphyrin and tin protoporphyrin, respectively.	tin protoporphyrin IX	73-91	heme oxygenase 1	Rattus norvegicus	0-4
12006174-5	2002	In contrast, inhibition of HO activity by tin protoporphyrin IX (SnPPIX) totally prevented cytokine-induced increase in VEGF, despite an augmented synthesis of intracellular NO.	tin protoporphyrin IX	65-71	vascular endothelial growth factor A	Rattus norvegicus	120-124
12006174-7	2002	Similarly, VEGF synthesis induced by hypoxia was down-regulated by SnPPIX, but not by inhibitors of NO synthase.	tin protoporphyrin IX	67-73	vascular endothelial growth factor A	Rattus norvegicus	11-15
11734449-6	2001	These effects of Hb were reduced by the HO-1 inhibitor tin-protoporphyrin (Sn-PP 20 micromol/kg), while Sn-PP had no effect in the absence of Hb.	tin protoporphyrin IX	55-73	heme oxygenase 1	Rattus norvegicus	40-44
12112002-8	2002	Under UVC (100 J/m(2)) and UVB (50 J/m(2)) irradiation, PGE(2) or SP-NO treatment prevents cells from UVC or UVB-induced cell death, and HO-1 inhibitor tin protoporphyrin (SnPP) reverses the preventive effects of PGE(2) and SP-NO.	tin protoporphyrin IX	152-170	heme oxygenase 1	Homo sapiens	137-141
11723024-6	2001	In a separate group of animals, concomitant treatment of Ad-HO-1 with the HO-1 inhibitor tin protoporphyrin completely restored each morphometric parameter to control levels.	tin protoporphyrin IX	89-107	heme oxygenase 1	Rattus norvegicus	60-64
11723024-6	2001	In a separate group of animals, concomitant treatment of Ad-HO-1 with the HO-1 inhibitor tin protoporphyrin completely restored each morphometric parameter to control levels.	tin protoporphyrin IX	89-107	heme oxygenase 1	Rattus norvegicus	74-78
11598499-10	2001	This protective effect of HO-1 was reversed by coincubation with tin protoporphyrin (SnPP9; 10(-5) mol/L), a selective inhibitor of HO-1 (P < 0.01).	tin protoporphyrin IX	65-83	heme oxygenase 1	Canis lupus familiaris	26-30
11598499-10	2001	This protective effect of HO-1 was reversed by coincubation with tin protoporphyrin (SnPP9; 10(-5) mol/L), a selective inhibitor of HO-1 (P < 0.01).	tin protoporphyrin IX	65-83	heme oxygenase 1	Canis lupus familiaris	132-136
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	73-79	tumor necrosis factor	Mus musculus	126-153
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	50-71	heme oxygenase 1	Mus musculus	23-27
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	73-79	tumor necrosis factor	Mus musculus	155-164
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	50-71	tumor necrosis factor	Mus musculus	126-153
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	73-79	interleukin 1 beta	Mus musculus	190-207
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	50-71	tumor necrosis factor	Mus musculus	155-164
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	73-79	interleukin 1 beta	Mus musculus	209-217
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	50-71	interleukin 1 beta	Mus musculus	190-207
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	50-71	interleukin 1 beta	Mus musculus	209-217
11260115-4	2001	In a second group of animals, after heat-shock priming, the action of HSP-32 was inhibited by tin protoporphyrin IX.	tin protoporphyrin IX	94-115	heme oxygenase 1	Rattus norvegicus	70-76
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	73-79	heme oxygenase 1	Mus musculus	23-27
11238670-5	2001	Under the same immunosuppressive regimen that allows mouse-to-rat cardiac transplants to survive long term (i.e., cobra venom factor plus cyclosporin A), inhibition of HO-1 activity by tin protoporphyrin, caused graft rejection in 3--7 days.	tin protoporphyrin IX	185-203	heme oxygenase 1	Rattus norvegicus	168-172
11238670-7	2001	Under inhibition of HO-1 activity by tin protoporphyrin, exogenous CO suppressed graft rejection and restored long-term graft survival.	tin protoporphyrin IX	37-55	heme oxygenase 1	Rattus norvegicus	20-24
11223432-3	2001	Rats were subjected to left carotid artery (LCA) balloon injury following pre-treatment with either vehicle, the HO-1 inducer hemin (50 mg/kg, SC), or concomitant treatment with hemin and the HO-1 inhibitor tin-protoporphyrin IX (SnPP-IX; 50 micromol/kg, IP).	tin protoporphyrin IX	207-228	heme oxygenase 1	Rattus norvegicus	192-196
11260115-10	2001	Inhibition of HSP-32 by tin protoporphyrin IX completely abolished the priming-induced improvement in capillary perfusion, as indicated by the lack of increased capillary diameters and volumetric blood flow.	tin protoporphyrin IX	24-45	heme oxygenase 1	Rattus norvegicus	14-20
11015442-4	2000	When HO-1 enzymatic activity is blocked by tin protoporphyrin (SnPPIX) or the action of CO is inhibited by hemoglobin (Hb), HO-1 no longer prevents EC apoptosis while these reagents do not affect the antiapoptotic action of bcl-2.	tin protoporphyrin IX	43-61	heme oxygenase 1	Homo sapiens	5-9
11076874-8	2000	This inhibitory effect was abolished by the HO-1 specific inhibitor tin protoporphyrin.	tin protoporphyrin IX	68-86	heme oxygenase 1	Homo sapiens	44-48
11530233-4	2001	After documenting the segmental and laminar distribution of Fos-positive nuclei following a 5% formalin injection, we went on to determine that the heme oxygenase inhibitor tin-protoporphyrin or morphine reduced this Fos expression as analyzed using confocal fluorescence microscopy.	tin protoporphyrin IX	173-191	FBJ osteosarcoma oncogene	Mus musculus	60-63
11530233-4	2001	After documenting the segmental and laminar distribution of Fos-positive nuclei following a 5% formalin injection, we went on to determine that the heme oxygenase inhibitor tin-protoporphyrin or morphine reduced this Fos expression as analyzed using confocal fluorescence microscopy.	tin protoporphyrin IX	173-191	FBJ osteosarcoma oncogene	Mus musculus	217-220
11015442-5	2000	Exposure of ECs to exogenous CO, under inhibition of HO-1 activity by SnPPIX, substitutes HO-1 in preventing EC apoptosis.	tin protoporphyrin IX	70-76	heme oxygenase 1	Homo sapiens	53-57
11015442-4	2000	When HO-1 enzymatic activity is blocked by tin protoporphyrin (SnPPIX) or the action of CO is inhibited by hemoglobin (Hb), HO-1 no longer prevents EC apoptosis while these reagents do not affect the antiapoptotic action of bcl-2.	tin protoporphyrin IX	63-69	heme oxygenase 1	Homo sapiens	5-9
10559009-7	1999	Incubation of platelets with PDGF-treated SMCs resulted in a significant increase in platelet cGMP concentration that was reversed by treatment of SMCs with the HO-1 inhibitor tin protoporphyrin-IX or by addition of the CO scavenger hemoglobin to platelets.	tin protoporphyrin IX	176-197	heme oxygenase 1	Rattus norvegicus	161-165
9335326-6	1997	Sn-protoporphyrin, an inhibitor of heme oxygenase (which releases iron from hemin), prevented hemin-induced suppression of TNF-alpha expression.	tin protoporphyrin IX	0-17	tumor necrosis factor	Homo sapiens	123-132
10232842-6	1999	An inhibitor of both HO-1 and heme-dependent guanylate cyclase (tin-protoporphyrin IX) greatly sensitized NO-pretreated NSC34 cells to the NO challenge.	tin protoporphyrin IX	64-85	heme oxygenase 1	Mus musculus	21-62
9441836-7	1997	Tin protoporphyrin-IX (SnPP, 25 microM), an inhibitor of heme oxygenase, was found to attenuate SIN-1-induced cytoprotection.	tin protoporphyrin IX	0-21	MAPK associated protein 1	Homo sapiens	96-101
10460761-5	1999	Tin protoporphyrin IX (50 micrometer) and zinc protoporphyrin IX (10 microM), inhibitors of HO-1, reduced hemin-induced and IL-1beta-induced inhibitory effects.	tin protoporphyrin IX	0-21	heme oxygenase 1	Homo sapiens	92-96
10460761-5	1999	Tin protoporphyrin IX (50 micrometer) and zinc protoporphyrin IX (10 microM), inhibitors of HO-1, reduced hemin-induced and IL-1beta-induced inhibitory effects.	tin protoporphyrin IX	0-21	interleukin 1 beta	Homo sapiens	124-132
10425182-7	1999	Local application of tin protoporphyrin, a HO inhibitor, blocked this effect, suggesting that induced HO-1 in the carotid artery was responsible for the inhibition of neointimal formation after balloon injury.	tin protoporphyrin IX	21-39	heme oxygenase 1	Rattus norvegicus	102-106
9884071-9	1998	In contrast, the selective inhibitor of haeme oxygenase, tin protoporphyrin IX (SnPP-IX, 10 microM), restored the pressor response to PE in SNAP-treated rings whilst markedly reducing CO and cyclic GMP production.	tin protoporphyrin IX	57-78	5'-nucleotidase, cytosolic II	Homo sapiens	198-201
9884071-9	1998	In contrast, the selective inhibitor of haeme oxygenase, tin protoporphyrin IX (SnPP-IX, 10 microM), restored the pressor response to PE in SNAP-treated rings whilst markedly reducing CO and cyclic GMP production.	tin protoporphyrin IX	80-87	5'-nucleotidase, cytosolic II	Homo sapiens	198-201
9239406-10	1997	Treatment of sheared SMCs with the HO-1 inhibitor, tin protoporphyrin-IX, blocked the antiaggregatory effect of the cells, whereas the iNOS inhibitor, methyl--arginine, had no effect.	tin protoporphyrin IX	51-72	heme oxygenase 1	Rattus norvegicus	35-39
7647974-10	1995	Although, less effective than ZnPP, tin protoporphyrin-IX (SnPP; 0.1 mM) and protoporphyrin-IX (PP; 0.1 mM) also attenuated the VIP-evoked relaxation.	tin protoporphyrin IX	36-57	vasoactive intestinal peptide	Rattus norvegicus	128-131
8816811-10	1996	Tin protoporphyrin, a selective inhibitor of HO, reversed the growth arrest and ablated the increased survival against hyperoxia observed in the A549-A4 cells overexpressing HO-1.	tin protoporphyrin IX	0-18	heme oxygenase 1	Homo sapiens	174-178
9596945-1	1997	OBJECTIVE: The purification and identification of heme oxygenase isoforms (HO-1) and HO-2 from human liver were described and Sn-protoporphyrin (SnPP) was used to inhibit HO-1 activity in order to provide a new method for prevention and treatment of neonatal jaundice.	tin protoporphyrin IX	126-143	heme oxygenase 1	Homo sapiens	75-79
9596945-1	1997	OBJECTIVE: The purification and identification of heme oxygenase isoforms (HO-1) and HO-2 from human liver were described and Sn-protoporphyrin (SnPP) was used to inhibit HO-1 activity in order to provide a new method for prevention and treatment of neonatal jaundice.	tin protoporphyrin IX	126-143	heme oxygenase 1	Homo sapiens	171-175
9596945-1	1997	OBJECTIVE: The purification and identification of heme oxygenase isoforms (HO-1) and HO-2 from human liver were described and Sn-protoporphyrin (SnPP) was used to inhibit HO-1 activity in order to provide a new method for prevention and treatment of neonatal jaundice.	tin protoporphyrin IX	145-149	heme oxygenase 1	Homo sapiens	171-175
7589541-4	1995	Tin-protoporphyrin (SnPP) prevents protection, suggesting involvement of hsp32 (heme oxygenase) and/or guanylyl cyclase (GC).	tin protoporphyrin IX	0-18	heme oxygenase 1	Rattus norvegicus	73-78
8387947-1	1993	Exposure of Hep3B cells to metalloporphyrins (tinprotoporphyrin and heme) or cobalt chloride resulted in the production of a significant number of heme oxygenase transcripts, erythropoietin transcripts or both, as indicated by in situ hybridization.	tin protoporphyrin IX	46-63	erythropoietin	Homo sapiens	175-189
7746837-4	1995	This effect on ceruloplasmin was specific to cobalt-protoporphyrin, since equimolar doses (25 mumol/kg body weight) of both tin-protoporphyrin and iron-protoporphyrin did not produce changes in the levels of circulating ceruloplasmin.	tin protoporphyrin IX	124-142	ceruloplasmin	Rattus norvegicus	15-28
8340702-0	1993	Investigations on the role of hemopexin and albumin in plasma clearance and tissue distribution of Sn-protoporphyrin.	tin protoporphyrin IX	99-116	hemopexin	Rattus norvegicus	30-39
8387947-3	1993	Tin-protoporphyrin (10 mumol/L) produced an eightfold to 10-fold increase in erythropoietin RNA within 40 min.	tin protoporphyrin IX	0-18	erythropoietin	Homo sapiens	77-91
8387947-11	1993	Thus both erythropoietin and heme oxygenase genes appear to be expressed after treatment with tin-protoporphyrin, heme or cobalt chloride; however, the time and patterns of expression are different.	tin protoporphyrin IX	94-112	erythropoietin	Homo sapiens	10-24
2250572-2	1990	Sn-protoporphyrin, a potent inhibitor of heme degradation both in vitro and in vivo, when administered to rodents prior to doxorubicin, mitigates the drug-induced toxic actions which are reflected by the drug-induced decreases of both cellular heme and cytochrome P450 content.	tin protoporphyrin IX	0-17	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	253-268
8456113-5	1993	In contrast, tin-protoporphyrin enhanced the IFN-gamma effects as seen by increased neopterin production, enhanced tryptophan degradation, and elevated HLA-DR antigen expression on cells.	tin protoporphyrin IX	13-31	interferon gamma	Homo sapiens	45-54
1610897-3	1992	Western blot analysis of HO-2 in testes microsomes of Sn-protoporphyrin-treated rats revealed a dramatic disruption of the integrity of the HO-2 protein.	tin protoporphyrin IX	54-71	heme oxygenase 2	Rattus norvegicus	25-29
1610897-3	1992	Western blot analysis of HO-2 in testes microsomes of Sn-protoporphyrin-treated rats revealed a dramatic disruption of the integrity of the HO-2 protein.	tin protoporphyrin IX	54-71	heme oxygenase 2	Rattus norvegicus	140-144
1610897-8	1992	In in vitro studies with purified HO-1 and HO-2, both Sn- and Zn-protoporphyrins were equally inhibitory to HO-1 activity; Sn-protoporphyrin, however, was by far more inhibitory to HO-2-dependent activity than to that of HO-1.	tin protoporphyrin IX	123-140	heme oxygenase 2	Rattus norvegicus	181-185
1610897-9	1992	Together, these findings and the fact that HO-2 under normal conditions is the predominant form of the enzyme in most organs suggest that loss of HO-2 protein integrity may to a significant degree account for suppression of bilirubin formation by Sn-protoporphyrin.	tin protoporphyrin IX	247-264	heme oxygenase 2	Rattus norvegicus	43-47
1610897-9	1992	Together, these findings and the fact that HO-2 under normal conditions is the predominant form of the enzyme in most organs suggest that loss of HO-2 protein integrity may to a significant degree account for suppression of bilirubin formation by Sn-protoporphyrin.	tin protoporphyrin IX	247-264	heme oxygenase 2	Rattus norvegicus	146-150
1371161-1	1992	The present investigation provides evidence of the ability of Sn-protoporphyrin to cause striking alterations in adrenal and testicular cytochrome P-450-dependent steroidogenesis and defines the potential of this metalloporphyrin to serve as a cellular toxin.	tin protoporphyrin IX	62-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	136-152
1542552-7	1992	Disruption by Sn-protoporphyrin of adrenal hemoprotein-dependent functions was not restricted to steroidogenic activities and encompassed drug metabolism activity of the organ; benzo(a)pyrene hydroxylase activity of both the microsomal and the mitochondrial fractions, as well as the microsomal NADPH-cytochrome P-450 reductase activity, were significantly reduced.	tin protoporphyrin IX	14-31	cytochrome p450 oxidoreductase	Rattus norvegicus	295-327
2250572-3	1990	Sn-protoporphyrin thus provides a pharmacological means of protecting against the toxic effects of doxorubicin and other drugs which enhance heme oxygenase activity and thus decrease cellular heme and cytochrome P450 content in vivo.	tin protoporphyrin IX	0-17	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	201-216
33815094-8	2021	HO-1 inhibitor (Sn-protoporphyrin, SnPP) was used to suppress the function and expression of HO-1 in PD mice.	tin protoporphyrin IX	16-33	heme oxygenase 1	Mus musculus	0-4
33807391-6	2021	IL-8 mRNA expression was analyzed in saliva-stimulated THP-1 cells treated with CAPE and the heme oxygenase-1 (HO-1) inhibitor tin-protoporphyrin (SnPP).	tin protoporphyrin IX	127-145	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
33807391-6	2021	IL-8 mRNA expression was analyzed in saliva-stimulated THP-1 cells treated with CAPE and the heme oxygenase-1 (HO-1) inhibitor tin-protoporphyrin (SnPP).	tin protoporphyrin IX	127-145	heme oxygenase 1	Homo sapiens	93-109
33807391-6	2021	IL-8 mRNA expression was analyzed in saliva-stimulated THP-1 cells treated with CAPE and the heme oxygenase-1 (HO-1) inhibitor tin-protoporphyrin (SnPP).	tin protoporphyrin IX	127-145	heme oxygenase 1	Homo sapiens	111-115
33815094-8	2021	HO-1 inhibitor (Sn-protoporphyrin, SnPP) was used to suppress the function and expression of HO-1 in PD mice.	tin protoporphyrin IX	16-33	heme oxygenase 1	Mus musculus	93-97
34439456-9	2021	Furthermore, when the cells were pretreated with tin protoporphyrin (an HO-1 inhibitor), the anti-inflammatory effects of NeB were reduced.	tin protoporphyrin IX	49-67	heme oxygenase 1	Mus musculus	72-76
23216607-12	2013	Protective effects of hemin were reversed by co-administration of tin protoporphyrin, an HO-1 inhibitor.	tin protoporphyrin IX	66-84	heme oxygenase 1	Mus musculus	89-93
34863556-7	2022	Moreover, TinPPIX further augments the free heme level along with amplifies the CDT efficacy by disabling heme oxygenase-1 (HO-1)-mediated heme conversion into antioxidative bilirubin.	tin protoporphyrin IX	10-17	heme oxygenase 1	Homo sapiens	106-122
34863556-7	2022	Moreover, TinPPIX further augments the free heme level along with amplifies the CDT efficacy by disabling heme oxygenase-1 (HO-1)-mediated heme conversion into antioxidative bilirubin.	tin protoporphyrin IX	10-17	heme oxygenase 1	Homo sapiens	124-128
34575836-11	2021	The effects of compound 1 were partly reversed by co-treatment with a HO-1 inhibitor, tin protoporphyrin IX.	tin protoporphyrin IX	86-107	heme oxygenase 1	Homo sapiens	70-74
2512345-8	1989	Hemin and Sn-protoporphyrin, in combination with IL-2, increase IL-2R on PBMC.	tin protoporphyrin IX	10-27	interleukin 2 receptor subunit alpha	Homo sapiens	64-69
35453452-3	2022	We found that cell toxicity and mitochondrial depolarization by BTZ were increased upon inhibition of HO-1 and TLR4 by using tin protoporphyrin IX (SnPP) and TAK-242, respectively.	tin protoporphyrin IX	125-146	heme oxygenase 1	Homo sapiens	102-106
35453452-3	2022	We found that cell toxicity and mitochondrial depolarization by BTZ were increased upon inhibition of HO-1 and TLR4 by using tin protoporphyrin IX (SnPP) and TAK-242, respectively.	tin protoporphyrin IX	125-146	toll like receptor 4	Homo sapiens	111-115
2512345-10	1989	Sn-protoporphyrin, a more potent mitogen than hemin, fails to induce cytotoxicity, and has a marked inhibitory effect on cytotoxicity induced by IL-2.	tin protoporphyrin IX	0-17	interleukin 2	Homo sapiens	145-149
2512345-11	1989	Hemin and Sn-protoporphyrin stimulate TNF-alpha and IFN-gamma production by PBMC.	tin protoporphyrin IX	10-27	tumor necrosis factor	Homo sapiens	38-47
2512345-11	1989	Hemin and Sn-protoporphyrin stimulate TNF-alpha and IFN-gamma production by PBMC.	tin protoporphyrin IX	10-27	interferon gamma	Homo sapiens	52-61
3281127-0	1988	Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility.	tin protoporphyrin IX	0-17	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	107-110
3422558-0	1988	Tin-protoporphyrin inhibits heme oxygenase and prevents the decline in hepatic heme and cytochrome P-450 contents produced in nude mice by tumor transplantation.	tin protoporphyrin IX	0-18	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	88-104
2443589-6	1987	HBP was extensively photo-oxidized, as evidenced by a decrease in its antigenicity and electrophoretic mobility, and it was cross-linked by naturally occurring porphyrins as well as by the synthetic tin-protoporphyrin and hematoporphyrin derivative.	tin protoporphyrin IX	199-217	heme binding protein 1	Homo sapiens	0-3
3753975-10	1986	The apparent affinity of Sn-protoporphyrin for human serum albumin is less than 1/1000 that of heme and 1/30 to 1/100 that of protoporphyrin.	tin protoporphyrin IX	25-42	albumin	Homo sapiens	53-66
3753975-11	1986	Competition studies between heme and Sn-protoporphyrin and between bilirubin and Sn-protoporphyrin indicate that Sn-protoporphyrin distributes differently among porphyrin-binding sites on serum albumin than does heme and that it is also not an effective competitor with bilirubin for bilirubin-binding sites.	tin protoporphyrin IX	81-98	albumin	Homo sapiens	188-201
3753975-4	1986	We have investigated aspects of the chemistry of tin-protoporphyrin in aqueous solution and of its interactions with heme-binding proteins other than heme oxygenase, specifically apomyoglobin and human serum albumin.	tin protoporphyrin IX	49-67	albumin	Homo sapiens	202-215
3753975-11	1986	Competition studies between heme and Sn-protoporphyrin and between bilirubin and Sn-protoporphyrin indicate that Sn-protoporphyrin distributes differently among porphyrin-binding sites on serum albumin than does heme and that it is also not an effective competitor with bilirubin for bilirubin-binding sites.	tin protoporphyrin IX	81-98	albumin	Homo sapiens	188-201
3965510-0	1985	Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase.	tin protoporphyrin IX	0-17	tryptophan 2,3-dioxygenase	Homo sapiens	79-99
3753975-8	1986	Binding of Sn-protoporphyrin to both apomyoglobin and serum albumin is unexpectedly weak.	tin protoporphyrin IX	11-28	albumin	Homo sapiens	54-67
3753872-4	1986	SnCl2 did not alter the heme saturation of tryptophan pyrrolase; however, treatment of rats with Sn-protoporphyrin, a potent competitive inhibitor of heme oxygenase activity both in vivo and in vitro, produced a rapid and complete heme saturation of tryptophan pyrrolase.	tin protoporphyrin IX	97-114	tryptophan 2,3-dioxygenase	Rattus norvegicus	250-270
3753872-5	1986	In addition, upon simultaneous administration of Sn-protoporphyrin and CoCl2, Sn-protoporphyrin prevented the CoCl2-mediated decrease in heme saturation of tryptophan pyrrolase.	tin protoporphyrin IX	49-66	tryptophan 2,3-dioxygenase	Rattus norvegicus	156-176
3753872-5	1986	In addition, upon simultaneous administration of Sn-protoporphyrin and CoCl2, Sn-protoporphyrin prevented the CoCl2-mediated decrease in heme saturation of tryptophan pyrrolase.	tin protoporphyrin IX	78-95	tryptophan 2,3-dioxygenase	Rattus norvegicus	156-176
3965510-5	1985	Sn-protoporphyrin, in doses (10 mumol/kg body wt) which entirely suppress neonatal hyperbilirubinemia in the experimental animal, leads to a very rapid (approximately 30-60 min) increase in the heme saturation of tryptophan pyrrolase from normal levels of approximately 50-60% to nearly 100%.	tin protoporphyrin IX	0-17	tryptophan 2,3-dioxygenase	Homo sapiens	213-233
3965510-6	1985	The effect peaks at 1-2 h and lasts for at least 12 h. Sn-protoporphyrin is also able to block the rapid and marked decline in heme saturation of tryptophan pyrrolase elicited by inorganic cobalt, a potent inducer of heme oxygenase in liver.	tin protoporphyrin IX	55-72	tryptophan 2,3-dioxygenase	Homo sapiens	146-166
3965510-7	1985	These findings establish clearly that after the administration of Sn-protoporphyrin in the whole animal, a functionally active heme pool, the one related to tryptophan pyrrolase, is rapidly increased in liver, confirming that the metalloporphyrin inhibits the degradation of endogenous heme by heme oxygenase.	tin protoporphyrin IX	66-83	tryptophan 2,3-dioxygenase	Homo sapiens	157-177
33668397-8	2021	An inhibitor assay using tin protoporphyrin IX (SnPP) confirmed that the enhancement of HO-1 by pre-treatment with THF protects SH-SY5y cells from CoCl2-induced neurotoxicity under hypoxic conditions.	tin protoporphyrin IX	25-46	heme oxygenase 1	Homo sapiens	88-92
33713981-4	2021	Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs.	tin protoporphyrin IX	73-94	heme oxygenase 1	Rattus norvegicus	58-62
33713981-4	2021	Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs.	tin protoporphyrin IX	73-94	NLR family, pyrin domain containing 3	Rattus norvegicus	146-151
33713981-4	2021	Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs.	tin protoporphyrin IX	73-94	caspase 1	Rattus norvegicus	156-165
33713981-4	2021	Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs.	tin protoporphyrin IX	73-94	heat shock protein family B (small) member 6	Rattus norvegicus	167-170
33713981-4	2021	Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs.	tin protoporphyrin IX	96-102	NFE2 like bZIP transcription factor 2	Rattus norvegicus	9-13
33713981-4	2021	Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs.	tin protoporphyrin IX	96-102	heme oxygenase 1	Rattus norvegicus	58-62
33713981-4	2021	Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs.	tin protoporphyrin IX	96-102	NLR family, pyrin domain containing 3	Rattus norvegicus	146-151
33713981-4	2021	Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs.	tin protoporphyrin IX	96-102	caspase 1	Rattus norvegicus	156-165
33713981-4	2021	Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs.	tin protoporphyrin IX	96-102	heat shock protein family B (small) member 6	Rattus norvegicus	167-170
33584308-10	2020	Interestingly, ALI dose-dependently inhibited these protein contents of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and glutathione peroxidase 4 (GPX4), which could be partly rescued by Tin-protoporphyrin IX (SnPP) and mitoTEMPO co-treatment.	tin protoporphyrin IX	219-240	NFE2 like bZIP transcription factor 2	Homo sapiens	72-115
33584308-10	2020	Interestingly, ALI dose-dependently inhibited these protein contents of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and glutathione peroxidase 4 (GPX4), which could be partly rescued by Tin-protoporphyrin IX (SnPP) and mitoTEMPO co-treatment.	tin protoporphyrin IX	219-240	glutathione peroxidase 4	Homo sapiens	153-177
33584308-10	2020	Interestingly, ALI dose-dependently inhibited these protein contents of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and glutathione peroxidase 4 (GPX4), which could be partly rescued by Tin-protoporphyrin IX (SnPP) and mitoTEMPO co-treatment.	tin protoporphyrin IX	219-240	glutathione peroxidase 4	Homo sapiens	179-183
33615179-5	2021	Previously, aqueous tin protoporphyrin IX (SnPPIX), a heme oxygenase-1 inhibitor, administered as multiple daily intraperitoneal (IP) injections, showed considerable antitubercular efficacy and treatment shortening capabilities as a host-directed therapy in infected mice.	tin protoporphyrin IX	20-41	heme oxygenase 1	Mus musculus	54-70
33615179-5	2021	Previously, aqueous tin protoporphyrin IX (SnPPIX), a heme oxygenase-1 inhibitor, administered as multiple daily intraperitoneal (IP) injections, showed considerable antitubercular efficacy and treatment shortening capabilities as a host-directed therapy in infected mice.	tin protoporphyrin IX	43-49	heme oxygenase 1	Mus musculus	54-70
33381031-8	2020	Induction of HO-1 by ferric protoporphyrin IX (FePP) inhibited TPA-induced uPAR expression, and this effect was abolished by treatment with the HO-1 inhibitor tin protoporphyrin IX (SnPP).	tin protoporphyrin IX	159-180	heme oxygenase 1	Homo sapiens	13-17
33381031-8	2020	Induction of HO-1 by ferric protoporphyrin IX (FePP) inhibited TPA-induced uPAR expression, and this effect was abolished by treatment with the HO-1 inhibitor tin protoporphyrin IX (SnPP).	tin protoporphyrin IX	159-180	plasminogen activator, urokinase receptor	Homo sapiens	75-79
33381031-8	2020	Induction of HO-1 by ferric protoporphyrin IX (FePP) inhibited TPA-induced uPAR expression, and this effect was abolished by treatment with the HO-1 inhibitor tin protoporphyrin IX (SnPP).	tin protoporphyrin IX	159-180	heme oxygenase 1	Homo sapiens	144-148
33076330-6	2020	Similarly, knockdown of HO-1 by siRNA or inhibition of HO-1 activity by tin protoporphyrin IX (SnPPIX) had no effect on CBD-induced autophagy and metabolic activity.	tin protoporphyrin IX	72-93	heme oxygenase 1	Homo sapiens	55-59
32558263-11	2020	Further, inhibition of heme oxygenase activity with tin protoporphyrin markedly reduces melanosphere formation driven by either Bach1 derepression or B-RafV600E expression.	tin protoporphyrin IX	52-70	BTB domain and CNC homolog 1	Homo sapiens	128-133
33076330-6	2020	Similarly, knockdown of HO-1 by siRNA or inhibition of HO-1 activity by tin protoporphyrin IX (SnPPIX) had no effect on CBD-induced autophagy and metabolic activity.	tin protoporphyrin IX	95-101	heme oxygenase 1	Homo sapiens	55-59
33076330-9	2020	Remarkably, inhibition of HO-1 by SnPPIX under conditions of autophagy deficit led to a significant reversal of apoptosis in cannabinoid-treated cells.	tin protoporphyrin IX	34-40	heme oxygenase 1	Homo sapiens	26-30
32321531-14	2020	HO-1 inhibitor tin protoporphyrin IX (SnPP IX) reversed the effects of ALT on Beas-2B and NHBE cell inflammation, apoptosis and oxidative stress.	tin protoporphyrin IX	15-36	heme oxygenase 1	Mus musculus	0-4
32940965-0	2020	The NRF2 stimulating agent, tin protoporphyrin, activates protective cytokine pathways in healthy human subjects and in patients with chronic kidney disease.	tin protoporphyrin IX	28-46	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
32940965-1	2020	BACKGROUND: Tin protoporphyrin (SnPP), a heme oxygenase 1 (HO-1) inhibitor, triggers adaptive tissue responses that confer potent protection against acute renal- and extra-renal tissue injuries.	tin protoporphyrin IX	12-30	heme oxygenase 1	Homo sapiens	41-57
32940965-1	2020	BACKGROUND: Tin protoporphyrin (SnPP), a heme oxygenase 1 (HO-1) inhibitor, triggers adaptive tissue responses that confer potent protection against acute renal- and extra-renal tissue injuries.	tin protoporphyrin IX	12-30	heme oxygenase 1	Homo sapiens	59-63
32650596-8	2020	The anti-inflammatory, anti-neuroinflammatory, and neuroprotective effects of kuwanon C were reversed when co-treatment with HO-1 inhibitor of tin protoporphyrin-IX (SnPP).	tin protoporphyrin IX	143-164	heme oxygenase 1	Mus musculus	125-129
32879134-8	2020	Moreover, IL-10 improved capillary density, reduced apoptosis, and decreased inflammation in the border zone of the infarcted hearts, findings that were partially inhibited by Tin protoporphyrin (a heme oxygenase-1 inhibitor).	tin protoporphyrin IX	176-194	interleukin 10	Mus musculus	10-15
32879134-8	2020	Moreover, IL-10 improved capillary density, reduced apoptosis, and decreased inflammation in the border zone of the infarcted hearts, findings that were partially inhibited by Tin protoporphyrin (a heme oxygenase-1 inhibitor).	tin protoporphyrin IX	176-194	heme oxygenase 1	Mus musculus	198-214
32854434-7	2020	Treatment with the HO-1 inhibitor tin-protoporphyrin IX revealed that these protective effects were exerted due to an increase in HO-1 expression induced by CTO.	tin protoporphyrin IX	34-55	heme oxygenase 1	Homo sapiens	19-23
32854434-7	2020	Treatment with the HO-1 inhibitor tin-protoporphyrin IX revealed that these protective effects were exerted due to an increase in HO-1 expression induced by CTO.	tin protoporphyrin IX	34-55	heme oxygenase 1	Homo sapiens	130-134
32708634-9	2020	On the other hand, the inhibition of HO-1 activity with tin protoporphyrin IX (SnPPIX) or knockdown of HO-1 expression by Nrf2 siRNA was associated with a decrease in CBD-mediated autophagy and apoptosis.	tin protoporphyrin IX	56-77	heme oxygenase 1	Homo sapiens	37-41
32708634-9	2020	On the other hand, the inhibition of HO-1 activity with tin protoporphyrin IX (SnPPIX) or knockdown of HO-1 expression by Nrf2 siRNA was associated with a decrease in CBD-mediated autophagy and apoptosis.	tin protoporphyrin IX	79-85	heme oxygenase 1	Homo sapiens	37-41
32747020-6	2020	Further study showed that BNF inhibited activation of NF-kappaB pathway via promoting HO-1, and SnPP IX (a HO-1 inhibitor) could inhibit anti-inflammatory function of BNF.	tin protoporphyrin IX	96-103	heme oxygenase 1	Mus musculus	107-111
32291269-4	2020	Tin protoporphyrin (SnPP) induces mild, transient oxidant stress in mice, triggering increased expression of select antioxidant proteins (e.g., heme oxygenase 1 [HO-1], NAD[P]H dehydrogenase [quinone] 1 [NQO1], ferritin, p21).	tin protoporphyrin IX	0-18	heme oxygenase 1	Mus musculus	144-160
32291269-4	2020	Tin protoporphyrin (SnPP) induces mild, transient oxidant stress in mice, triggering increased expression of select antioxidant proteins (e.g., heme oxygenase 1 [HO-1], NAD[P]H dehydrogenase [quinone] 1 [NQO1], ferritin, p21).	tin protoporphyrin IX	0-18	heme oxygenase 1	Mus musculus	162-166
32291269-4	2020	Tin protoporphyrin (SnPP) induces mild, transient oxidant stress in mice, triggering increased expression of select antioxidant proteins (e.g., heme oxygenase 1 [HO-1], NAD[P]H dehydrogenase [quinone] 1 [NQO1], ferritin, p21).	tin protoporphyrin IX	0-18	NAD(P)H dehydrogenase, quinone 1	Mus musculus	169-202
32291269-4	2020	Tin protoporphyrin (SnPP) induces mild, transient oxidant stress in mice, triggering increased expression of select antioxidant proteins (e.g., heme oxygenase 1 [HO-1], NAD[P]H dehydrogenase [quinone] 1 [NQO1], ferritin, p21).	tin protoporphyrin IX	0-18	NAD(P)H dehydrogenase, quinone 1	Mus musculus	204-208
32291269-4	2020	Tin protoporphyrin (SnPP) induces mild, transient oxidant stress in mice, triggering increased expression of select antioxidant proteins (e.g., heme oxygenase 1 [HO-1], NAD[P]H dehydrogenase [quinone] 1 [NQO1], ferritin, p21).	tin protoporphyrin IX	0-18	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	221-224
32321531-14	2020	HO-1 inhibitor tin protoporphyrin IX (SnPP IX) reversed the effects of ALT on Beas-2B and NHBE cell inflammation, apoptosis and oxidative stress.	tin protoporphyrin IX	38-45	heme oxygenase 1	Mus musculus	0-4
32106625-6	2020	Interference of HO-1 activity by tin protoporphyrin IX (SnPP) impeded the alleviative effects of IAA on expression of IL-1beta and IL-6 induced by LPS, whereas demonstrated no effect on its suppression of ROS and NO production.	tin protoporphyrin IX	33-54	heme oxygenase 1	Mus musculus	16-20
31964423-12	2020	HMOX1 inhibition by tin protoporphyrin (SnPP) in normal DBMSCs resulted in a reduction in proliferation, migration, adhesion, and clone formation processes as compared to the untreated controls.	tin protoporphyrin IX	20-38	heme oxygenase 1	Homo sapiens	0-5
31964423-12	2020	HMOX1 inhibition by tin protoporphyrin (SnPP) in normal DBMSCs resulted in a reduction in proliferation, migration, adhesion, and clone formation processes as compared to the untreated controls.	tin protoporphyrin IX	40-44	heme oxygenase 1	Homo sapiens	0-5
31952230-6	2020	These inhibitory effects of HO-1 were reversed by tin protoporphyrin (SnPP)IX or by transfection with HO-1 siRNA.	tin protoporphyrin IX	50-68	heme oxygenase 1	Homo sapiens	28-32
31952230-6	2020	These inhibitory effects of HO-1 were reversed by tin protoporphyrin (SnPP)IX or by transfection with HO-1 siRNA.	tin protoporphyrin IX	70-74	heme oxygenase 1	Homo sapiens	28-32
30773786-7	2019	The HO-1 inhibitor tin protoporphyrin IX prevented the anti-senescence action evoked by Ang-(1-7) or recombinant klotho.	tin protoporphyrin IX	19-40	heme oxygenase 1	Homo sapiens	4-8
31251921-6	2019	Mechanistically, the protective effects of quercetin were (1) linked to increased expression of HO-1 in the presence or absence of lipopolysaccharide (LPS), (2) similar to that observed with the NADPH oxidase inhibitor apocynin, and (3) could be abolished by the specific small-interfering RNA against HO-1 expression or HO-1 activity inhibitor tin protoporphyrin.	tin protoporphyrin IX	345-363	heme oxygenase 1	Mus musculus	96-100
30773786-7	2019	The HO-1 inhibitor tin protoporphyrin IX prevented the anti-senescence action evoked by Ang-(1-7) or recombinant klotho.	tin protoporphyrin IX	19-40	angiopoietin 1	Homo sapiens	88-96
30773786-7	2019	The HO-1 inhibitor tin protoporphyrin IX prevented the anti-senescence action evoked by Ang-(1-7) or recombinant klotho.	tin protoporphyrin IX	19-40	klotho	Homo sapiens	113-119
30605726-8	2019	The beneficial effects of GYY4137 above were reversed by the HO-1 inhibitor tin protoporphyrin (SnPP).	tin protoporphyrin IX	76-94	heme oxygenase 1	Mus musculus	61-65
31071151-13	2019	Co-treatment of mice with atorvastatin and tin protoporphyrin IX (SnPPIX), an inhibitor of heme oxygenase, reversed the inhibitory effect of statin on cell influx and proinflammatory markers, suggesting a protective role of HO-1.	tin protoporphyrin IX	43-64	heme oxygenase 1	Mus musculus	224-228
31071151-13	2019	Co-treatment of mice with atorvastatin and tin protoporphyrin IX (SnPPIX), an inhibitor of heme oxygenase, reversed the inhibitory effect of statin on cell influx and proinflammatory markers, suggesting a protective role of HO-1.	tin protoporphyrin IX	66-72	heme oxygenase 1	Mus musculus	224-228
30884345-13	2019	We also found that the inhibitory effect of L2H17 on the inflammatory responses was attenuated by an inhibitor of HO-1 activity, Tin protoporphyrin IX (SnPP).	tin protoporphyrin IX	129-150	heme oxygenase 1	Homo sapiens	114-118
30738992-8	2019	Inhibition of HO-1 by tin protoporphyrin IX abolished the protective effects of DN on pancreatic damage.	tin protoporphyrin IX	22-43	heme oxygenase 1	Mus musculus	14-18
30534628-9	2018	HO-1 inhibitor tin protoporphyrin IX (SnPP) prevented the antiallodynic effects of gabapentinoids (pregabalin or gabapentin) during SNI-induced mechanical allodynia.	tin protoporphyrin IX	15-36	heme oxygenase 1	Mus musculus	0-4
30609764-9	2019	Inhibition of HO-1 by tin protoporphyrin, a synthetic inhibitor, reduced the protective effect of PC-1.	tin protoporphyrin IX	22-40	heme oxygenase 1	Mus musculus	14-18
30609764-9	2019	Inhibition of HO-1 by tin protoporphyrin, a synthetic inhibitor, reduced the protective effect of PC-1.	tin protoporphyrin IX	22-40	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	98-102
30076913-7	2018	Moreover, by administration of HO-1 inhibitors, tin protoporphyrin and zinc protoporphyrin, fisetin-reduced MMP-2 and MMP-9 expressions were reversed.	tin protoporphyrin IX	48-66	heme oxygenase 1	Mus musculus	31-35
30076913-7	2018	Moreover, by administration of HO-1 inhibitors, tin protoporphyrin and zinc protoporphyrin, fisetin-reduced MMP-2 and MMP-9 expressions were reversed.	tin protoporphyrin IX	48-66	matrix metallopeptidase 2	Mus musculus	108-113
30076913-7	2018	Moreover, by administration of HO-1 inhibitors, tin protoporphyrin and zinc protoporphyrin, fisetin-reduced MMP-2 and MMP-9 expressions were reversed.	tin protoporphyrin IX	48-66	matrix metallopeptidase 9	Mus musculus	118-123
29738777-0	2018	Heme oxygenase-1 inhibitor tin-protoporphyrin improves liver regeneration after partial hepatectomy.	tin protoporphyrin IX	27-45	heme oxygenase 1	Rattus norvegicus	0-16
29738777-1	2018	AIMS: This study investigates the effects of the heme oxygenase-1 (HO-1) inhibitor tin protoporphyrin IX (SnPP), on rat liver regeneration following 2/3 partial hepatectomy (PH) in order to clarify the controversial role of HO-1 in the regulation of cellular growth.	tin protoporphyrin IX	83-104	heme oxygenase 1	Rattus norvegicus	49-65
29738777-1	2018	AIMS: This study investigates the effects of the heme oxygenase-1 (HO-1) inhibitor tin protoporphyrin IX (SnPP), on rat liver regeneration following 2/3 partial hepatectomy (PH) in order to clarify the controversial role of HO-1 in the regulation of cellular growth.	tin protoporphyrin IX	83-104	heme oxygenase 1	Rattus norvegicus	67-71
29567472-13	2018	Pre-treatment of sn-protoporphyrin (SnPP), an important HO-1 inhibitor, abolished the role of SOAT1 inhibition in suppressing inflammation and abnormal cholesterol transportation.	tin protoporphyrin IX	17-34	sterol O-acyltransferase 1	Mus musculus	94-99
29567472-13	2018	Pre-treatment of sn-protoporphyrin (SnPP), an important HO-1 inhibitor, abolished the role of SOAT1 inhibition in suppressing inflammation and abnormal cholesterol transportation.	tin protoporphyrin IX	36-40	sterol O-acyltransferase 1	Mus musculus	94-99
28586635-0	2017	Tin protoporphyrin activates the oxidant-dependent NRF2-cytoprotective pathway and mitigates acute kidney injury.	tin protoporphyrin IX	0-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-55
28606512-9	2017	Additionally, RK inhibited lipid accumulation, and adipogenic transcription factor and lipogenic protein expressions were all decreased by inhibiting HO-1 or beta-catenin using tin protoporphyrin (SnPP) or beta-catenin short-interfering RNA (siRNA), respectively.	tin protoporphyrin IX	177-195	heme oxygenase 1	Mus musculus	150-154
28606512-9	2017	Additionally, RK inhibited lipid accumulation, and adipogenic transcription factor and lipogenic protein expressions were all decreased by inhibiting HO-1 or beta-catenin using tin protoporphyrin (SnPP) or beta-catenin short-interfering RNA (siRNA), respectively.	tin protoporphyrin IX	177-195	catenin (cadherin associated protein), beta 1	Mus musculus	158-170
28146411-5	2017	Inhibition of the antioxidant enzyme HO-1 by tin protoporphyrin abolished the neuroprotective effect of the SH extract, suggesting an important role of HO-1 in protection against glutamate-induced neural damage.	tin protoporphyrin IX	45-63	heme oxygenase 1	Mus musculus	37-41
29694434-10	2018	Inhibition of HO-1 activity with tin protoporphyrin blocked the protections afforded by haptoglobin and hemopexin in SS-mice.	tin protoporphyrin IX	33-51	heme oxygenase 1	Mus musculus	14-18
29694434-10	2018	Inhibition of HO-1 activity with tin protoporphyrin blocked the protections afforded by haptoglobin and hemopexin in SS-mice.	tin protoporphyrin IX	33-51	haptoglobin	Mus musculus	88-99
29694434-10	2018	Inhibition of HO-1 activity with tin protoporphyrin blocked the protections afforded by haptoglobin and hemopexin in SS-mice.	tin protoporphyrin IX	33-51	hemopexin	Mus musculus	104-113
28589248-5	2017	Tin protoporphyrin (SnPP) is a HO-1 inhibitor.	tin protoporphyrin IX	0-18	heme oxygenase 1	Rattus norvegicus	31-35
29152091-7	2017	A selective inhibitor for HO-1, Tin-Protoporphyrin, prevented the FGF-2 protection against cell death.	tin protoporphyrin IX	32-50	heme oxygenase 1	Homo sapiens	26-30
29152091-7	2017	A selective inhibitor for HO-1, Tin-Protoporphyrin, prevented the FGF-2 protection against cell death.	tin protoporphyrin IX	32-50	fibroblast growth factor 2	Homo sapiens	66-71
28635609-6	2017	In order to elucidate the possible role of HO-1 in mediating the protective effects of ghrelin, tin protoporphyrin (SnPP) HO-1 blocker was administrated; it significantly attenuated the gastroprotective effect of ghrelin.	tin protoporphyrin IX	96-114	ghrelin and obestatin prepropeptide	Rattus norvegicus	87-94
28635609-6	2017	In order to elucidate the possible role of HO-1 in mediating the protective effects of ghrelin, tin protoporphyrin (SnPP) HO-1 blocker was administrated; it significantly attenuated the gastroprotective effect of ghrelin.	tin protoporphyrin IX	96-114	heme oxygenase 1	Rattus norvegicus	122-126
26914345-7	2017	The inhibitory effect of DMF was abrogated by the heme oxygenase-1 (HO-1) inhibitor tin protoporphyrin.	tin protoporphyrin IX	84-102	heme oxygenase 1	Mus musculus	50-66
26914345-7	2017	The inhibitory effect of DMF was abrogated by the heme oxygenase-1 (HO-1) inhibitor tin protoporphyrin.	tin protoporphyrin IX	84-102	heme oxygenase 1	Mus musculus	68-72
28116663-11	2017	HO-1 was inhibited by Sn-protoporphyrin, HO-1 inhibitor, and increased by cobalt protopophyrin, HO-1 inducer.	tin protoporphyrin IX	22-39	heme oxygenase 1	Homo sapiens	0-4