PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9867872-1	1999	The Ah receptor (AhR) mediates many of the toxic responses induced by polyhalogenated and polycyclic hydrocarbons (PAHs) which are ubiquitous environmental contaminants causing toxic responses in human and wildlife.	Hydrocarbons, Cyclic	90-113	aryl hydrocarbon receptor	Homo sapiens	4-15
10977129-3	2000	Polycyclic hydrocarbons, such as acenaphthylene, were recently found to induce cytochrome P450 1A2 gene expression in young DBA2 mice by aromatic hydrocarbon receptor-independent pathways.	Hydrocarbons, Cyclic	0-23	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	79-98
10424773-7	1999	Because of the ubiquitous nature of 3MC-inducible CYP1A1 throughout the animal rather than just "portals of entry," these results support our hypothesis that CYP1A1, induced by particular endogenous signals in various tissues and cell types, might participate in one or more critical life processes--in addition to its well-established role of metabolism of polycyclic hydrocarbons, certain drugs, and other environmental pollutants.	Hydrocarbons, Cyclic	358-381	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	50-56
10424773-7	1999	Because of the ubiquitous nature of 3MC-inducible CYP1A1 throughout the animal rather than just "portals of entry," these results support our hypothesis that CYP1A1, induced by particular endogenous signals in various tissues and cell types, might participate in one or more critical life processes--in addition to its well-established role of metabolism of polycyclic hydrocarbons, certain drugs, and other environmental pollutants.	Hydrocarbons, Cyclic	358-381	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	158-164
9867872-1	1999	The Ah receptor (AhR) mediates many of the toxic responses induced by polyhalogenated and polycyclic hydrocarbons (PAHs) which are ubiquitous environmental contaminants causing toxic responses in human and wildlife.	Hydrocarbons, Cyclic	90-113	aryl hydrocarbon receptor	Homo sapiens	17-20
8079350-0	1994	Induction of CYP1A1 gene expression in mouse hepatoma cells by benzo[e]pyrene, a ligand of the 4S polycyclic hydrocarbon-binding protein.	Hydrocarbons, Cyclic	98-120	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	13-19
9804920-1	1998	Bitumen samples and fumes consist essentially of polycyclic hydrocarbons (PAH) and their derivatives, some of which are known to be carcinogenic or co-carcinogenic in animals.	Hydrocarbons, Cyclic	49-72	phenylalanine hydroxylase	Homo sapiens	74-77
9478971-2	1998	Transcriptional activation of the Cyp1B1 gene in rodents is stimulated by both polycyclic hydrocarbons and cAMP.	Hydrocarbons, Cyclic	79-102	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	34-40
9514075-1	1998	The tumor-associated aldehyde dehydrogenase 3 (ALDH3) and the glutathione transferase (GST)Ya form are coded by members of the Ah (aryl hydrocarbon) battery group of genes activated in the liver by polycyclic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Hydrocarbons, Cyclic	198-221	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	21-45
9514075-1	1998	The tumor-associated aldehyde dehydrogenase 3 (ALDH3) and the glutathione transferase (GST)Ya form are coded by members of the Ah (aryl hydrocarbon) battery group of genes activated in the liver by polycyclic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Hydrocarbons, Cyclic	198-221	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	47-52
9514075-1	1998	The tumor-associated aldehyde dehydrogenase 3 (ALDH3) and the glutathione transferase (GST)Ya form are coded by members of the Ah (aryl hydrocarbon) battery group of genes activated in the liver by polycyclic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Hydrocarbons, Cyclic	198-221	glutathione S-transferase alpha 4	Rattus norvegicus	62-85
9367523-1	1997	Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1.	Hydrocarbons, Cyclic	85-108	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	18-24
7740558-8	1995	By inducing CYP1A1, PCBs can trigger the "activation" of xenobiotics, such as polycyclic hydrocarbons, into mutagenic compounds.	Hydrocarbons, Cyclic	78-101	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	12-18
9743595-6	1998	Only the IA1 isozyme was observed to be inducible with selected polycyclic hydrocarbons.	Hydrocarbons, Cyclic	64-87	INSM transcriptional repressor 1	Homo sapiens	9-12
9760279-11	1998	We conclude that (i) several polycyclic hydrocarbons and their oxidation products are very inhibitory with respect to human P450s 1A1, 1A2, and 1B1; (ii) of these inhibitors only some are mechanism-based inactivators; and (iii) some of the inhibitors are potentially useful for distinguishing between human P450s 1A1 and 1B1.	Hydrocarbons, Cyclic	29-52	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	307-324
7574713-10	1995	Collectively, these findings suggest that, in addition to the Ah (dioxin) receptor, glycine N-methyltransferase appears to be both a polycyclic aromatic hydrocarbon-binding protein and a mediator of the induction of the cytochrome P4501A1 gene by polycyclic hydrocarbons such as benzo(a)pyrene.	Hydrocarbons, Cyclic	247-270	glycine N-methyltransferase	Rattus norvegicus	84-111
7574713-10	1995	Collectively, these findings suggest that, in addition to the Ah (dioxin) receptor, glycine N-methyltransferase appears to be both a polycyclic aromatic hydrocarbon-binding protein and a mediator of the induction of the cytochrome P4501A1 gene by polycyclic hydrocarbons such as benzo(a)pyrene.	Hydrocarbons, Cyclic	247-270	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	220-238
7744798-0	1995	Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1.	Hydrocarbons, Cyclic	58-80	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	32-47
7744798-0	1995	Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1.	Hydrocarbons, Cyclic	58-80	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	99-105
1694720-2	1990	One pivotal gene, CYP1A1, codes for an inducible cytochrome P450 isozyme (P450IA1) responsible for the bioactivation of numerous carcinogenic polycyclic hydrocarbons and aromatic amines.	Hydrocarbons, Cyclic	142-165	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	18-24
8037457-1	1994	Human cytochrome P450 (P450) 1A1 is primarily an extrahepatic enzyme and is important because of its roles in the activation of polycyclic hydrocarbons and other xenobiotic chemicals.	Hydrocarbons, Cyclic	128-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-32
2029514-0	1991	CO binding studies of engineered cytochrome P-450ds: effects of mutations at putative distal sites in the presence of polycyclic hydrocarbons.	Hydrocarbons, Cyclic	118-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-49
8395783-5	1993	It is most likely that the correlation between genetic differences in human or murine CYP1A1 inducibility by polycyclic hydrocarbons or TCDD and increased risk of cancer will be explained by differences in the AHR gene, leading to enhanced tumor promotion (rather than in the CYP1A1 structural gene).	Hydrocarbons, Cyclic	109-132	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	86-92
8395783-5	1993	It is most likely that the correlation between genetic differences in human or murine CYP1A1 inducibility by polycyclic hydrocarbons or TCDD and increased risk of cancer will be explained by differences in the AHR gene, leading to enhanced tumor promotion (rather than in the CYP1A1 structural gene).	Hydrocarbons, Cyclic	109-132	aryl-hydrocarbon receptor	Mus musculus	210-213
1306096-1	1992	We have conducted a pilot study to assess levels of cytochrome CYP1A1 gene expression in human peripheral lymphocytes as a molecular biomarker assay for polycyclic hydrocarbon exposure.	Hydrocarbons, Cyclic	153-175	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	63-69
2118391-4	1990	A possibility to use the method of the inhibitory analysis of fish microsomal activities by specific antibodies to the rat cytochrome P-450 isoforms for biomonitoring and biotesting of polycyclic hydrocarbons and polychlorinated biphenyls in aquatic systems is discussed.	Hydrocarbons, Cyclic	185-208	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	123-139
3293833-1	1988	A model has been proposed for the induction of cytochrome P450c in liver by polycyclic hydrocarbons such as benzo(a)pyrene (BaP) and 3-methylcholanthrene (3MC).	Hydrocarbons, Cyclic	76-99	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	47-63
2576817-1	1989	Certain strains of mice vary in their enzyme inducibility by polycyclic hydrocarbons, i.e., the strain C57 shows high and the strain DBA shows low inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]pyrene (BaP).	Hydrocarbons, Cyclic	61-84	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	163-191
2576817-1	1989	Certain strains of mice vary in their enzyme inducibility by polycyclic hydrocarbons, i.e., the strain C57 shows high and the strain DBA shows low inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]pyrene (BaP).	Hydrocarbons, Cyclic	61-84	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	193-196
35130690-0	2022	Nonbenzenoid High-Spin Polycyclic Hydrocarbons Generated by Atom Manipulation.	Hydrocarbons, Cyclic	23-46	spindlin 1	Homo sapiens	18-22
2477842-1	1989	The dioxin-inducible cytochrome P(1)450 (Cyp1a1 gene) and P(3)450 (Cyp1a2 gene) enzymes have been implicated in the metabolism of numerous polycyclic hydrocarbons and arylamines, respectively.	Hydrocarbons, Cyclic	139-162	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	41-47
2477842-1	1989	The dioxin-inducible cytochrome P(1)450 (Cyp1a1 gene) and P(3)450 (Cyp1a2 gene) enzymes have been implicated in the metabolism of numerous polycyclic hydrocarbons and arylamines, respectively.	Hydrocarbons, Cyclic	139-162	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	67-73
3179354-1	1988	Changes in the metabolic activity of 7-ethoxyresorufin in rat liver microsomes containing different amounts of cytochrome P-450 induced by 3-methylcholanthrene and other polycyclic hydrocarbons (P-450c) were studied.	Hydrocarbons, Cyclic	170-193	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	111-127
229673-3	1979	The contribution of the native high spin species to the total cytochrome P-450 content of microsomes was calculated to be between 40% and 65% after induction with phenobarbital and polycyclic hydrocarbons, respectively.	Hydrocarbons, Cyclic	181-204	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	62-78
3932282-7	1985	Treatment of hepatocytes with a-naphthoflavone, a selective inhibitor of polycyclic hydrocarbon-inducible cytochrome P-450 form(s), prior to exposure to the heterocyclic amines completely inhibited the mutagenic effect in the bacteria.	Hydrocarbons, Cyclic	73-95	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	106-122
2988922-12	1985	A polycyclic hydrocarbon, benzo(a)pyrene, which causes induction of aryl hydrocarbon hydroxylase activity in fetal hepatocytes, inhibited the stimulation of aromatase activity by dexamethasone.	Hydrocarbons, Cyclic	2-24	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	68-96
6150709-9	1984	Some compounds including polycyclic hydrocarbons and warfarin induced ECD but had no associated effect on GGT in hepatocytes.	Hydrocarbons, Cyclic	25-48	ecdysoneless cell cycle regulator	Rattus norvegicus	70-73
6353196-2	1983	The content and inventory of the types of cytochrome P-450 is readily modified following in vivo treatment of animals with "inducing agents" such as barbiturates, steroids and polycyclic hydrocarbons.	Hydrocarbons, Cyclic	176-199	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	42-58
6960350-7	1982	This demonstrates that different forms of cytochrome P-450 may catalyze the epoxidation reaction preferentially at different sides of the methyl-substituted double bond of a planar polycyclic hydrocarbon molecule.	Hydrocarbons, Cyclic	181-203	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	42-58
6286112-1	1982	Human colon tumor cells (cell line LS174T) retain a cytochrome P-450-containing drug metabolism system capable of hydroxylating polycyclic hydrocarbons and the anticancer drug cyclophosphamide.	Hydrocarbons, Cyclic	128-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	52-68
6180607-4	1982	Extensive studies by Huggins and by others have shown that the quinone reductase in liver and some other tissues of rats is inducible by various polycyclic hydrocarbons and aromatic amines, as well as by certain azo dyes.	Hydrocarbons, Cyclic	145-168	crystallin, zeta	Mus musculus	63-80
3695475-1	1987	The structural requirements for the interaction of about 80 cyclic hydrocarbons and related compounds with the androgen receptor of rat ventral prostate, the estrogen receptor of human breast tumor MCF-7 cells, and the glucocorticoid receptor of rat liver were examined by comparing their abilities to compete with radioactive hormones for binding to the respective receptors.	Hydrocarbons, Cyclic	60-79	androgen receptor	Rattus norvegicus	111-128
3695475-1	1987	The structural requirements for the interaction of about 80 cyclic hydrocarbons and related compounds with the androgen receptor of rat ventral prostate, the estrogen receptor of human breast tumor MCF-7 cells, and the glucocorticoid receptor of rat liver were examined by comparing their abilities to compete with radioactive hormones for binding to the respective receptors.	Hydrocarbons, Cyclic	60-79	nuclear receptor subfamily 3 group C member 1	Homo sapiens	219-242
3695475-5	1987	The androgen receptor can interact stereospecifically with nonoxygenated and nonalkylated cyclic hydrocarbons, such as 10,11-dihydro-5H-dibenzo[a,d] cycloheptene or 9,10-dihydrophenanthrene, which can, in vivo, inhibit the androgen-dependent growth of the male accessory reproductive organs.	Hydrocarbons, Cyclic	90-109	androgen receptor	Homo sapiens	4-21
3536915-2	1986	NAD(P)H:menadione oxidoreductase induction by polycyclic hydrocarbons is known to be governed by the aromatic hydrocarbon-responsive (Ah) locus.	Hydrocarbons, Cyclic	46-69	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	0-32
3705617-6	1986	It is concluded that mouse skin contains multiple forms of cytochrome P-450, and that forms functionally analogous to those induced by polycyclic hydrocarbons in rodent liver are present in untreated mouse skin.	Hydrocarbons, Cyclic	135-158	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	59-75
4059324-1	1985	The microsomal cytochrome P-450-dependent aryl hydrocarbon hydroxylase is important in the detoxification of polycyclic hydrocarbons as well as their activation to cytotoxic or carcinogenic derivatives.	Hydrocarbons, Cyclic	109-132	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	42-70
288333-3	1979	In both tissues, the induced AHH presents the same in vitro sensitivity to various inhibitors as a polycyclic hydrocarbon induced AHH.	Hydrocarbons, Cyclic	99-121	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	29-32
288333-3	1979	In both tissues, the induced AHH presents the same in vitro sensitivity to various inhibitors as a polycyclic hydrocarbon induced AHH.	Hydrocarbons, Cyclic	99-121	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	130-133
399458-4	1979	Finally, nuclei have been demonstrated to catalyze the formation of benzo[a]pyrene syn- and anti-diolepoxides, ultimate carcinogenic forms of this polycyclic hydrocarbon.	Hydrocarbons, Cyclic	147-169	synemin	Homo sapiens	83-86
711851-5	1978	AHH, a cytochrome P-450 dependent carcinogen-metabolizing enzyme appears to play an important role in the activation of polycyclic hydrocarbons into reactive moieties that can bind to DNA and that may directly induce cancer.	Hydrocarbons, Cyclic	120-143	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-3
17539139-7	1978	Studies of mixed function oxidases and cytochrome P-450 system in male gonads demonstrated that the presence of AHH, EH, and GSH-ST implicate activation and detoxification of polycyclic hydrocarbons.	Hydrocarbons, Cyclic	175-198	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-55
711851-5	1978	AHH, a cytochrome P-450 dependent carcinogen-metabolizing enzyme appears to play an important role in the activation of polycyclic hydrocarbons into reactive moieties that can bind to DNA and that may directly induce cancer.	Hydrocarbons, Cyclic	120-143	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	7-23
619902-0	1978	Specificity of human, rat and mouse skin epoxide hydratase towards K-region epoxides of polycyclic hydrocarbons.	Hydrocarbons, Cyclic	88-111	epoxide hydrolase 2, cytoplasmic	Mus musculus	41-58
4850644-0	1974	Aryl hydrocarbon hydroxylase activity induced by cannabis resin: analysis for polycyclic hydrocarbons.	Hydrocarbons, Cyclic	78-101	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-28
898314-4	1977	Administration of actinomycin D simultaneously with polycyclic hydrocarbons prevents intensification of the CCl4 hepatotoxic effect caused by 3-methylcholanthrene and dibenz (a, h) anthracene.	Hydrocarbons, Cyclic	52-75	C-C motif chemokine ligand 4	Rattus norvegicus	108-112
821485-0	1976	The role of epidermal aryl hydrocarbon hydroxylase in the covalent binding of polycyclic hydrocarbon to DNA and its relationship to tumor initiation.	Hydrocarbons, Cyclic	78-100	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	22-50
1244357-8	1976	Dissociation was clearest with inducers of the polycyclic hydrocarbon type which led to great induction of monooxygenase while epoxide hydratase remained unchanged.	Hydrocarbons, Cyclic	47-69	epoxide hydrolase 2	Rattus norvegicus	127-144
1192552-4	1975	This property was used to detect low concentration (0.1 muM) of polycyclic hydrocarbons which are strong AHH inducers and which may also be carcinogenic.	Hydrocarbons, Cyclic	64-87	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	105-108
1192552-6	1975	A possible mechanism of action for the in vitro behaviour of polycyclic hydrocarbons and 7,8-BF towards AHH is proposed.	Hydrocarbons, Cyclic	61-84	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	104-107
1134200-0	1975	Induction of aryl hydrocarbon hydroxylase in human fetal liver cell and fibroblast cultures by polycyclic hydrocarbons.	Hydrocarbons, Cyclic	95-118	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	13-41
991864-0	1976	Epoxides derived from various polycyclic hydrocarbons as substrates of homogeneous and microsome-bound epoxide hydratase.	Hydrocarbons, Cyclic	30-53	epoxide hydrolase 2	Rattus norvegicus	103-120
991864-13	1976	All six arene oxides derived from polycyclic hydrocarbons were substrates for the homogeneous epoxide hydratase that was isolated from rat liver microsomal fractions using styrene oxide, an alkene oxide, as substrate to follow the purification.	Hydrocarbons, Cyclic	34-57	epoxide hydrolase 2	Rattus norvegicus	94-111
971515-6	1976	The relationship between induction of AHH activity by polycyclic hydrocarbons in B6 mice and the concomitant synthesis of cytochrome P-448 is discussed.	Hydrocarbons, Cyclic	54-77	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	38-41
1447-2	1976	In general, unsubstituted polycyclic hydrocarbons caused a greater induction of epidermal AHH than substituted one (1,2,3,4-dibenzanthracene greater than 1,2,5,6-dibenzanthracene greater than benz (a)anthracene equal 3-methylcholanthrene greater than 7,12-dimethlbenz (a)anthracene) which did not correlate with their ability to initiate tumors in mouse skin.	Hydrocarbons, Cyclic	26-49	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	90-93
4119360-0	1972	Studies on the induction of serum hemopexin by pentobarbital and polycyclic hydrocarbons.	Hydrocarbons, Cyclic	65-88	hemopexin	Homo sapiens	34-43
5547730-1	1971	Aryl hydrocarbon hydroxylase induction by phenobarbital, polycyclic hydrocarbons, and the insecticide, 2.2-bis(p-chlorophenyl)-1,1,1-trichloroethane (p,p"-DDT), occurs in rat fetal liver cell cultures.	Hydrocarbons, Cyclic	57-80	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-28
4099847-0	1971	Properties of cytochrome P-450 as affected by environmental factors: qualitative changes due to administration of polycyclic hydrocarbons.	Hydrocarbons, Cyclic	114-137	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-30
15551138-7	2004	There is some evidence that exposure to polycyclic hydrocarbons, paints and lacquer, and stone dust may modify the expression of Ku 70 mRNA.	Hydrocarbons, Cyclic	40-63	X-ray repair cross complementing 6	Homo sapiens	129-134
19850099-9	2009	Collectively, these results suggest that AhR ligands, such as polycyclic hydrocarbons, can modify GAPDH expression and, therefore, have the potential to alter the multiple functions of this enzyme.	Hydrocarbons, Cyclic	62-85	aryl-hydrocarbon receptor	Mus musculus	41-44
19850099-9	2009	Collectively, these results suggest that AhR ligands, such as polycyclic hydrocarbons, can modify GAPDH expression and, therefore, have the potential to alter the multiple functions of this enzyme.	Hydrocarbons, Cyclic	62-85	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	98-103
31488357-4	2019	Compounds bearing smaller or larger polycyclic hydrocarbons than adamantane yielded all good inhibition potency of the human sEH (0.4 <= IC50 <= 21.7 nM), indicating that sEH is able to accommodate inhibitors of very different size.	Hydrocarbons, Cyclic	36-59	epoxide hydrolase 2	Homo sapiens	125-128
31488357-4	2019	Compounds bearing smaller or larger polycyclic hydrocarbons than adamantane yielded all good inhibition potency of the human sEH (0.4 <= IC50 <= 21.7 nM), indicating that sEH is able to accommodate inhibitors of very different size.	Hydrocarbons, Cyclic	36-59	epoxide hydrolase 2	Homo sapiens	177-180
26247835-2	2016	The polycyclic hydrocarbons (PAHs), pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene, were found to induce Type I binding spectra with human cytochrome P450 (P450) 2A13 and were converted to various mono- and di-oxygenated products by this enzyme.	Hydrocarbons, Cyclic	4-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	150-177
21755929-1	2011	With ab initio MP2 computational methods, a theoretical study has been carried out to characterize the interaction between aliphatic cyclic hydrocarbons, as models of molecular hydrocarbon monolayers, with cations (Li(+), Na(+), and K(+)), anions (F(-), Cl(-), and Br(-)), and both simultaneously in opposite faces of the hydrocarbons.	Hydrocarbons, Cyclic	133-152	tryptase pseudogene 1	Homo sapiens	15-18
20572170-0	2010	Theoretical design of high-spin polycyclic hydrocarbons.	Hydrocarbons, Cyclic	32-55	spindlin 1	Homo sapiens	27-31
17936463-8	2008	Using recombinant bacterial tester strains in mutagenicity assays, we observed SULT1C3-mediated activation of several large benzylic alcohols derived from alkylated polycyclic hydrocarbons: 1-hydroxymethylpyrene, both enantiomers of 1-(alpha-hydroxy)ethylpyrene, 6-hydroxymethylbenzo[a]pyrene and 6-hydroxymethylanthanthrene.	Hydrocarbons, Cyclic	165-188	sulfotransferase family 1C member 3	Homo sapiens	79-86
17103398-1	2007	A series of cyclic hydrocarbons analogs where a carbon displays unusual planar tetracoordinate structure is proposed, employing hybrid density functional theory calculations using B3LYP functional and 6-311+G** basis set.	Hydrocarbons, Cyclic	12-31	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	182-185
16551781-2	2006	Both cytochromes P450 have been reported to be overexpressed in human tumors, and cytochrome P450 2S1 is induced by carcinogenic polycyclic hydrocarbons.	Hydrocarbons, Cyclic	129-152	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	82-101
12604189-1	2003	The aldehyde dehydrogenase-3A1 (ALDH3A1) enzyme, encoded by a member of the [Ah]-gene family, is dramatically increased (more than 100-fold) by benzo[a]pyrene (BaP) and other polycyclic hydrocarbons.	Hydrocarbons, Cyclic	175-198	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	4-30
12604189-1	2003	The aldehyde dehydrogenase-3A1 (ALDH3A1) enzyme, encoded by a member of the [Ah]-gene family, is dramatically increased (more than 100-fold) by benzo[a]pyrene (BaP) and other polycyclic hydrocarbons.	Hydrocarbons, Cyclic	175-198	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	32-39
14618622-1	2004	Cigarette smoke contains polycyclic hydrocarbons and arylamines that may both be activated by sulfotransferase, encoded by SULT1A1.	Hydrocarbons, Cyclic	25-48	sulfotransferase family 1A member 1	Homo sapiens	123-130
12144816-3	2002	The cytochrome P450 1A1 (CYP1A1) gene polymorphism may play role in the development of epithelial ovarian neoplasm by detoxification of polycyclic hydrocarbons and other compounds and the concentration of estrogens and their metabolites.	Hydrocarbons, Cyclic	136-159	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	4-23
12144816-3	2002	The cytochrome P450 1A1 (CYP1A1) gene polymorphism may play role in the development of epithelial ovarian neoplasm by detoxification of polycyclic hydrocarbons and other compounds and the concentration of estrogens and their metabolites.	Hydrocarbons, Cyclic	136-159	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	25-31