PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1450954-0 1992 Neuroprotective effect of protein kinase C inhibitors on oxygen/glucose free-induced decreases in 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices. Oxygen 57-63 carbonic anhydrase 1 Rattus norvegicus 124-127 1450954-0 1992 Neuroprotective effect of protein kinase C inhibitors on oxygen/glucose free-induced decreases in 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices. Glucose 64-71 carbonic anhydrase 1 Rattus norvegicus 124-127 1450954-2 1992 We have demonstrated that rat hippocampal slices exposed to oxygen/glucose-free medium showed decreases in 2-deoxyglucose (2-DG) uptake and CA1 field potentials elicited by the stimulation of Schaffer collaterals. Oxygen 60-66 carbonic anhydrase 1 Rattus norvegicus 140-143 1450954-2 1992 We have demonstrated that rat hippocampal slices exposed to oxygen/glucose-free medium showed decreases in 2-deoxyglucose (2-DG) uptake and CA1 field potentials elicited by the stimulation of Schaffer collaterals. Glucose 67-74 carbonic anhydrase 1 Rattus norvegicus 140-143 1450954-3 1992 Therefore we examined the effect of protein kinase C inhibitors on oxygen/glucose free-induced impairments of 2-DG uptake and CA1 field potentials. Oxygen 67-73 carbonic anhydrase 1 Rattus norvegicus 126-129 1450954-3 1992 Therefore we examined the effect of protein kinase C inhibitors on oxygen/glucose free-induced impairments of 2-DG uptake and CA1 field potentials. Glucose 74-81 carbonic anhydrase 1 Rattus norvegicus 126-129 1450954-4 1992 Pretreatment with staurosporine, K252a and H-7 attenuated decreases in 2-DG uptake and CA1 field potentials. Staurosporine 18-31 carbonic anhydrase 1 Rattus norvegicus 87-90 1450954-6 1992 Therefore we examined the effect of pretreatment with phorbol ester for 90 min on oxygen/glucose free-induced decreases in 2-DG uptake and CA1 field potentials. Phorbol Esters 54-67 carbonic anhydrase 1 Rattus norvegicus 139-142 1450954-6 1992 Therefore we examined the effect of pretreatment with phorbol ester for 90 min on oxygen/glucose free-induced decreases in 2-DG uptake and CA1 field potentials. Oxygen 82-88 carbonic anhydrase 1 Rattus norvegicus 139-142 1450954-6 1992 Therefore we examined the effect of pretreatment with phorbol ester for 90 min on oxygen/glucose free-induced decreases in 2-DG uptake and CA1 field potentials. Glucose 89-96 carbonic anhydrase 1 Rattus norvegicus 139-142 23199535-11 2012 Low Mg levels, high TG levels in association with enhanced HbA1c levels could thus serve as a reliable biochemical indicator of insulin status and action without resorting to the usage of criteria for insulin sensitivity and resistance. Magnesium 4-6 insulin Homo sapiens 128-135 22779914-3 2012 As expected from sequence alignments, CIB2-4 were shown to bind calcium (Ca(2+)) and magnesium (Mg(2+)) ions. Magnesium 85-94 calcium and integrin binding family member 2 Homo sapiens 38-44 22992416-12 2012 CONCLUSION: The data suggest that Zn-induced leptin resistance can be attenuated through restoring the ionic balance of Zn, Cu and Mg through inclusion of antioxidants in diet such as these modified eggs. Magnesium 131-133 leptin Rattus norvegicus 45-51 22556098-5 2012 In 2-parameter models, Mg, Ca, or pH are selected by stepwise multiple regression for Ni, Cu, and Zn HC5, respectively, and increase the accuracy to 87%-94%. Magnesium 23-25 CYCS pseudogene 1 Homo sapiens 101-104 22556098-7 2012 Three-parameter models have DOC and pH in common, the third parameter is Mg, Ca, or Na for HC5 of Ni, Cu, and Zn, respectively. Magnesium 73-75 CYCS pseudogene 1 Homo sapiens 91-94 22972143-5 2012 SELECTION CRITERIA: Randomized controlled trials (RCTs) of magnesium supplementation (in any form) to prevent skeletal muscle cramps in any patient group (i.e. all clinical presentations of cramp). Magnesium 59-68 cathelicidin antimicrobial peptide Homo sapiens 126-131 22762246-12 2012 CONCLUSIONS: The cases of PPIH show severe symptoms of magnesium depletion and identification of its causation was only possible through withdrawal of the PPI. Magnesium 55-64 peptidylprolyl isomerase H Homo sapiens 26-30 22854408-1 2012 BACKGROUND: Dietary magnesium might be related to colorectal tumor risk through the pivotal roles of magnesium in cellular metabolism, insulin resistance, and systemic inflammation. Magnesium 20-29 insulin Homo sapiens 135-142 22310734-11 2012 Levels of TBARS and MPO were significantly lower than those of I/R group in Magnesium-treated group. Magnesium 76-85 myeloperoxidase Rattus norvegicus 20-23 22310734-13 2012 Increased TBARS and MPO activity can be inhibited by magnesium treatment. Magnesium 53-62 myeloperoxidase Rattus norvegicus 20-23 22659570-4 2012 Stimulation of MG-63 cells with LPA or synthetic LPA receptor agonists resulted in p42/44 MAPK phosphorylation via LPA(1)-LPA(3) receptors. Magnesium 15-17 erythrocyte membrane protein band 4.2 Homo sapiens 83-86 22659570-4 2012 Stimulation of MG-63 cells with LPA or synthetic LPA receptor agonists resulted in p42/44 MAPK phosphorylation via LPA(1)-LPA(3) receptors. Magnesium 15-17 lysophosphatidic acid receptor 1 Homo sapiens 115-121 22922232-3 2012 A characteristic property of TRPM7 channels is their sensitivity to intracellular Mg ( 2+) and pH. Magnesium 82-84 transient receptor potential cation channel subfamily M member 7 Homo sapiens 29-34 22897576-0 2012 Restricting dietary magnesium accelerates ectopic connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-) ). Magnesium 20-29 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 Mus musculus 129-139 22897576-10 2012 Our findings indicate that the mineral content, particularly magnesium, can modify the extent and the onset of mineralization in Abcc6(-/-) mice and suggest that dietary magnesium levels may contribute to the phenotypic variability of PXE. Magnesium 61-70 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 Mus musculus 129-134 22846351-3 2012 In general, 95% filtered magnesium is collectively reabsorbed in the proximal tubule (15%-20%) , thick ascending limb of Henle (TAL, 65%-75%) , and the distal convoluted tubule (DCT, 5%-10%) . Magnesium 25-34 leucine rich repeat and sterile alpha motif containing 1 Homo sapiens 128-131 22846351-4 2012 In the TAL, magnesium reabsorption regulated by the paracellular pathway via claudin-16 is driven by electrochemical voltage. Magnesium 12-21 leucine rich repeat and sterile alpha motif containing 1 Homo sapiens 7-10 22846351-4 2012 In the TAL, magnesium reabsorption regulated by the paracellular pathway via claudin-16 is driven by electrochemical voltage. Magnesium 12-21 claudin 16 Homo sapiens 77-87 22846351-6 2012 In the DCT, the transcellular pathway via transient receptor potential melastatin 6 (TRPM6) plays a fundamental role in the final 5%-10% magnesium reabsorption. Magnesium 137-146 transient receptor potential cation channel subfamily M member 6 Homo sapiens 42-83 22846351-6 2012 In the DCT, the transcellular pathway via transient receptor potential melastatin 6 (TRPM6) plays a fundamental role in the final 5%-10% magnesium reabsorption. Magnesium 137-146 transient receptor potential cation channel subfamily M member 6 Homo sapiens 85-90 22846360-2 2012 In addition, magnesium replacement therapy improves insulin resistance and glycemic control. Magnesium 13-22 insulin Homo sapiens 52-59 22846360-3 2012 Low levels of magnesium in the venous blood induce the disturbances of auto-phosphylation on the insulin receptor and deteriorate insulin resistance. Magnesium 14-23 insulin receptor Homo sapiens 97-113 22846360-3 2012 Low levels of magnesium in the venous blood induce the disturbances of auto-phosphylation on the insulin receptor and deteriorate insulin resistance. Magnesium 14-23 insulin Homo sapiens 97-104 22842399-3 2012 Upon dehydriding, MgH(2) first decomposed to convert to Mg and liberate hydrogen with an on-set temperature of ~290 C. Subsequently, LiBH(4) reacted with CaH(2) to form CaB(6) and LiH in addition to further hydrogen release. Magnesium 18-20 neural proliferation, differentiation and control 1 Homo sapiens 170-173 22891322-7 2012 In isolated perfused TAL tubules of claudin-10-deficient mice, paracellular permeability of sodium is decreased, and the relative permeability of calcium and magnesium is increased. Magnesium 158-167 claudin 10 Mus musculus 36-46 22901676-0 2012 Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore. Magnesium 13-22 caspase 3 Homo sapiens 52-61 22803592-0 2012 X-ray structures of magnesium and manganese complexes with the N-terminal domain of calmodulin: insights into the mechanism and specificity of metal ion binding to an EF-hand. Magnesium 20-29 calmodulin 1 Homo sapiens 84-94 22803592-1 2012 Calmodulin (CaM), a member of the EF-hand superfamily, regulates many aspects of cell function by responding specifically to micromolar concentrations of Ca(2+) in the presence of an ~1000-fold higher concentration of cellular Mg(2+). Magnesium 227-229 calmodulin 1 Homo sapiens 0-10 22803592-1 2012 Calmodulin (CaM), a member of the EF-hand superfamily, regulates many aspects of cell function by responding specifically to micromolar concentrations of Ca(2+) in the presence of an ~1000-fold higher concentration of cellular Mg(2+). Magnesium 227-229 calmodulin 1 Homo sapiens 12-15 22803592-2 2012 To explain the structural basis of metal ion binding specificity, we have determined the X-ray structures of the N-terminal domain of calmodulin (N-CaM) in complexes with Mg(2+), Mn(2+), and Zn(2+). Magnesium 171-173 calmodulin 1 Homo sapiens 134-144 22803592-2 2012 To explain the structural basis of metal ion binding specificity, we have determined the X-ray structures of the N-terminal domain of calmodulin (N-CaM) in complexes with Mg(2+), Mn(2+), and Zn(2+). Magnesium 171-173 neural cell adhesion molecule 1 Homo sapiens 146-151 22587440-5 2012 Depletion of TRPM7 lowered cellular Mg(2+), decreased the concentration of ROS and lessened p38 MAPK (mitogen-activated protein kinase) and JNK (c-Jun N-terminal kinase) activation as well as decreased caspase 3 activation and PARP [poly(ADP-ribose) polymerase] cleavage in response to apoptotic stimuli. Magnesium 36-38 transient receptor potential cation channel subfamily M member 7 Homo sapiens 13-18 22587440-8 2012 Taken together, these data uncover an essential role for Mg(2+) in TRPM7"s control of cell survival and in the regulation of cellular ROS levels. Magnesium 57-59 transient receptor potential cation channel subfamily M member 7 Homo sapiens 67-72 22646904-7 2012 Since hypomagnesemia alone can trigger oxidative stress and cardiac injury, we suggest that inhibition of EGFR-TK caused magnesium wasting, which partly contributed to decreased cardiac contractility. Magnesium 121-130 epidermal growth factor receptor Rattus norvegicus 106-110 22668657-5 2012 Membrane associated ATPase functions that are crucial in regulating the intracellular ionic environment, are magnesium-dependent. Magnesium 109-118 dynein axonemal heavy chain 8 Homo sapiens 20-26 22634382-0 2012 TRPM7: a unique channel involved in magnesium homeostasis. Magnesium 36-45 transient receptor potential cation channel subfamily M member 7 Homo sapiens 0-5 22395648-1 2012 Three magnesium ions (Mg(2+)), named Mg1 (in Mid domain), Mg2 and Mg3 (both in PIWI domain), located at the small RNA binding domain of Argonaute (Ago) protein, are important for sequence-specific miRNA-target interactions. Magnesium 6-15 mucin 5B, oligomeric mucus/gel-forming Homo sapiens 37-40 22752972-7 2012 Using magnesium we were able to produce a clip sufficiently small to close vocal fold incisions. Magnesium 6-15 CAP-Gly domain containing linker protein 1 Homo sapiens 42-46 22710690-3 2012 Significant fluorescence enhancement is observed with MS1 in the presence of Hg(2+); the metal ions Ag(+), Ca(2+), Cd(2+), Co(2+), Cu(2+), Fe(2+), Fe(3+), K(+), Mg(2+), Mn(2+), Ni(2+), Pb(2+), and Zn(2+) cause only minor changes in the fluorescence of the system. Magnesium 161-163 MS Homo sapiens 54-57 22750005-8 2012 Our structure revealed that the non-hydrolysable, constitutively active form of Rab6A" can accommodate GDP/Mg(2+) in the open conformation. Magnesium 107-109 RAB6A, member RAS oncogene family Homo sapiens 80-85 22633825-0 2012 Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Magnesium 0-9 achaete-scute family bHLH transcription factor 2 Homo sapiens 51-57 22484167-2 2012 The presence of hardness salts results in an essential increase of the SDS adsorption activity, which indicates the formation of Ca(DS)(2) and Mg(DS)(2) in the SDS solutions. Magnesium 143-145 serine dehydratase Homo sapiens 71-74 22484167-2 2012 The presence of hardness salts results in an essential increase of the SDS adsorption activity, which indicates the formation of Ca(DS)(2) and Mg(DS)(2) in the SDS solutions. Magnesium 143-145 serine dehydratase Homo sapiens 160-163 22484167-3 2012 The surface tension isotherms of SDS in presence of Ca(DS)(2) and Mg(DS)(2) are described using the generalised Frumkin model. Magnesium 66-68 serine dehydratase Homo sapiens 33-36 22662000-0 2012 The association of bone mineral density and parathyroid hormone with serum magnesium in adult patients with sickle-cell anaemia. Magnesium 75-84 parathyroid hormone Homo sapiens 44-63 22225942-4 2012 The results present that uniform, nonporous, amorphous PLLA and semi-crystalline PCL films are coated on Mg. PLLA film shows better adhesion strength to Mg substrate than that of PCL film. Magnesium 105-107 PHD finger protein 1 Homo sapiens 81-84 23798918-1 2012 BACKGROUND: This study aimed to investigate whether magnesium supplementation might affect serum magnesium, high sensitive C-reactive protein (hs-CRP), plasma fibrinogen, and interleukin 6 (IL-6) levels in healthy middle-aged overweight women. Magnesium 52-61 C-reactive protein Homo sapiens 123-141 23798918-1 2012 BACKGROUND: This study aimed to investigate whether magnesium supplementation might affect serum magnesium, high sensitive C-reactive protein (hs-CRP), plasma fibrinogen, and interleukin 6 (IL-6) levels in healthy middle-aged overweight women. Magnesium 52-61 interleukin 6 Homo sapiens 175-188 23798918-1 2012 BACKGROUND: This study aimed to investigate whether magnesium supplementation might affect serum magnesium, high sensitive C-reactive protein (hs-CRP), plasma fibrinogen, and interleukin 6 (IL-6) levels in healthy middle-aged overweight women. Magnesium 52-61 interleukin 6 Homo sapiens 190-194 23798918-9 2012 Mean concentration of IL-6 was significantly increased in the magnesium group comparing the baseline value(P=0.001). Magnesium 62-71 interleukin 6 Homo sapiens 22-26 22995212-0 2012 Effects of a high-calcium diet on serum insulin-like growth factor-1 levels in magnesium-deficient rats. Magnesium 79-88 insulin-like growth factor 1 Rattus norvegicus 40-68 22995212-3 2012 Serum concentrations of osteocalcin and IGF-1 were significantly lower in rats fed the Mg-deficient diet than in rats fed the normal-Mg diet. Magnesium 87-89 bone gamma-carboxyglutamate protein Rattus norvegicus 24-35 22995212-3 2012 Serum concentrations of osteocalcin and IGF-1 were significantly lower in rats fed the Mg-deficient diet than in rats fed the normal-Mg diet. Magnesium 87-89 insulin-like growth factor 1 Rattus norvegicus 40-45 22995212-6 2012 Moreover, unchanged serum IGF-1 concentrations may contribute to the decreased bone formation seen in Mg-deficient rats receiving a high-Ca diet. Magnesium 102-104 insulin-like growth factor 1 Rattus norvegicus 26-31 23015202-0 2012 Down-regulation of hepatic phosphoenolpyruvate carboxykinase expression in magnesium-deficient rats. Magnesium 75-84 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 27-60 23015202-9 2012 We observed lower expression of hepatic PEPCK mRNA, in the magnesium-deficient rats, thus suggesting a possible compensatory mechanism to diminish glycogenesis. Magnesium 59-68 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 40-45 23015202-12 2012 Hyperinsulinemia induces hepatic down-regulation of PEPCK, and is possibly a key mechanism inducing the metabolic complications of magnesium deficiency. Magnesium 131-140 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 52-57 23092042-9 2012 Many studies have been conducted with results supporting the prophylactic use of amiodarone and beta-blockers, while the treatment with new agents such as magnesium, statins, omega-3 fatty acids and inhibitors of the renin-angiotensin-aldosterone system is still being investigated. Magnesium 155-164 renin Homo sapiens 217-222 22556412-7 2012 The inhibition of intrinsic AID enzymatic activity by Fe(2+) was specific, as shown by lack of inhibition of AID-mediated dC deamination by other bivalent metal ions, such as Zn(2+), Mn(2+), Mg(2+), or Ni(2+), and the inability of Fe(2+) to inhibit UNG-mediated dU excision. Magnesium 191-193 activation induced cytidine deaminase Homo sapiens 28-31 22460708-1 2012 Transient receptor potential melastatin 7 (TRPM7) channels were originally identified electrophysiologically when depletion of cytosolic Mg(2+) resulted in the gradual development of an outwardly rectifying cation current. Magnesium 137-139 transient receptor potential cation channel subfamily M member 7 Homo sapiens 43-48 22655012-6 2012 As an application of our device, we study the influence of divalent ions on vimentin intermediate filament networks in a quantitative way by tuning the magnesium concentration from drop to drop. Magnesium 152-161 vimentin Homo sapiens 76-84 22686203-6 2012 Baseline CIMT in Abcc6(-/-) versus Abcc6(+/+) mice was increased (p value = 0.009), whereas CIMT in magnesium-treated versus untreated Abcc6(-/-) mice was reduced (p value = 0.024). Magnesium 100-109 CIMT Homo sapiens 92-96 22406257-7 2012 There are case reports of seizures being controlled with magnesium supplementation in people with specific conditions, and recently in an open randomized trial, children with infantile spasms responded better to adrenocorticotropic hormone (ACTH) plus magnesium than to ACTH alone. Magnesium 57-66 proopiomelanocortin Homo sapiens 212-239 22406257-7 2012 There are case reports of seizures being controlled with magnesium supplementation in people with specific conditions, and recently in an open randomized trial, children with infantile spasms responded better to adrenocorticotropic hormone (ACTH) plus magnesium than to ACTH alone. Magnesium 57-66 proopiomelanocortin Homo sapiens 241-245 23155975-9 2012 While mean serum ET-1 levels in the group with low magnesium levels were significantly higher than that of the group with normal magnesium levels (p < 0.05), mean bone mineral density and bone mineral content levels were significantly lower (p < 0.05). Magnesium 51-60 endothelin 1 Homo sapiens 17-21 22668657-7 2012 Magnesium deficiency by interfering with ATPase functions causes increased intracellular calcium and sodium and decreases intracellular potassium concentration. Magnesium 0-9 dynein axonemal heavy chain 8 Homo sapiens 41-47 22508922-7 2012 Children given magnesium were more likely to have been previously admitted to ICU (odds ratio [OR] 11.2), hospitalized within the past year (OR 3.8), received corticosteroids before arrival (OR 4.0), presented with severe exacerbation (OR 6.1), and to have been treated at 1 particular center (OR 14.9). Magnesium 15-24 olfactory receptor family 5 subfamily K member 1 Homo sapiens 141-147 22508922-7 2012 Children given magnesium were more likely to have been previously admitted to ICU (odds ratio [OR] 11.2), hospitalized within the past year (OR 3.8), received corticosteroids before arrival (OR 4.0), presented with severe exacerbation (OR 6.1), and to have been treated at 1 particular center (OR 14.9). Magnesium 15-24 olfactory receptor family 3 subfamily A member 1 Homo sapiens 191-197 22508922-7 2012 Children given magnesium were more likely to have been previously admitted to ICU (odds ratio [OR] 11.2), hospitalized within the past year (OR 3.8), received corticosteroids before arrival (OR 4.0), presented with severe exacerbation (OR 6.1), and to have been treated at 1 particular center (OR 14.9). Magnesium 15-24 olfactory receptor family 2 subfamily I member 1 pseudogene Homo sapiens 236-242 22450164-5 2012 The nuclease activity of the His-AtCaN2 fusion protein was highest at 37 C, required a neutral or weakly-alkaline environment, and was stimulated by Ca(2+) and Mg(2+), but inhibited by Zn(2+) and high concentration of Mn(2+). Magnesium 160-162 Ca(2+)-dependent nuclease family protein Arabidopsis thaliana 33-39 22460768-1 2012 We report on the electrochemical characteristics of GaN nanowire (NW) ensembles grown by plasma-assisted molecular beam epitaxy on Si111 substrates and on the influence of Si and Mg doping. Magnesium 179-181 gigaxonin Homo sapiens 52-55 22416042-5 2012 In the case of o-SLG, the addition of Cu(2+) and Mg(2+) ions maintained the gelating ability of the compound, whilst Zn(2+) and Ni(2+) ions destroyed the gel. Magnesium 49-51 sialic acid binding Ig like lectin 12 Homo sapiens 17-20 22587269-3 2012 We show that the ultraviolet photoluminescence peak attributed to Mg acceptors in GaN is likely related to Mg-H complexes, explaining the results of photoluminescence and electron paramagnetic resonance experiments. Magnesium 66-68 gigaxonin Homo sapiens 82-85 22301056-2 2012 Studies performed in native and heterologous expression systems have shown that TRPM7 forms nonselective cation channels functional in the plasma membrane and activated on depletion of cellular Mg(2+). Magnesium 194-196 transient receptor potential cation channel subfamily M member 7 Homo sapiens 80-85 22301056-6 2012 In the present study we investigated intracellular Mg(2+) and pH dependence of native TRPM7 currents using whole cell patch-clamp electrophysiology in human Jurkat T lymphocytes and HEK293 cells. Magnesium 51-53 transient receptor potential cation channel subfamily M member 7 Homo sapiens 86-91 22301056-8 2012 Additionally, we present data on amplitude distribution of preactivated TRPM7 currents in Jurkat T lymphocytes in the absence of prior Mg(2+) or proton depletion. Magnesium 135-137 transient receptor potential cation channel subfamily M member 7 Homo sapiens 72-77 22203099-3 2012 Yeast hexokinase A exists as a MG state at pH 2.5 that does not show any cooperative transition upon heating. Magnesium 31-33 hexokinase Saccharomyces cerevisiae S288C 6-16 22236806-2 2012 CcO includes 13 different protein subunits, 7 species of phospholipids, 7 species of triglycerides, 4 redox-active metal sites (Cu(A), heme a (Fe(a)), Cu(B), heme a(3) (Fe(a3))) and 3 redox-inactive metal sites (Mg(2+), Zn(2+) and Na(+)). Magnesium 212-214 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 0-3 22287575-5 2012 HW was generated by immersing a magnesium stick in tap water (Mg + 2H(2)O Mg (OH)(2) + H(2)). Magnesium 32-41 USO1 vesicle transport factor Rattus norvegicus 51-54 19793331-14 2012 Regarding the mineral composition, in ML-GH group increments in concentrations of phosphorus (10.70 vs 10.34; p = .013) were observed at 2 weeks and of magnesium (0.29 vs 0.25; p = .019) 5 weeks after implantation. Magnesium 152-161 somatotropin Canis lupus familiaris 41-43 22415230-6 2012 Similarly, magnesium intakes were significantly inversely associated with concentrations of plasma C-peptide in age-adjusted model (P(trend)=0.002) but not in multivariate-adjusted model (P(trend)=0.61). Magnesium 11-20 insulin Homo sapiens 99-108 22169953-2 2012 We have analyzed the effects of Mg(2+) and Zn(2+) on the conformational activation process based on NMR measurements of [methyl-(13)C]methionine DNA polymerase beta. Magnesium 32-34 DNA polymerase beta Homo sapiens 145-164 22291014-3 2012 Metal binding constants for BDP, determined by competition isothermal titration calorimetry, are 2.4 nm and 10 mum for Mn(2+) and Mg(2+) ions, respectively. Magnesium 130-132 protein phosphatase, Mg2+/Mn2+ dependent 1K Homo sapiens 28-31 22422993-7 2012 X-ray crystallography of the RUC-2-alpha(IIb)beta(3) headpiece complex in 1 mM calcium ion (Ca(2+))/5 mM Mg(2+) at 2.6 A revealed that RUC-2 binds to alpha(IIb) the way RUC-1 does, but in addition, it binds to the beta(3) MIDAS residue glutamic acid 220, thus displacing Mg(2+) from the MIDAS. Magnesium 105-107 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 45-52 22405347-0 2012 Characterization of magnesium requirement of human 5"-tyrosyl DNA phosphodiesterase mediated reaction. Magnesium 20-29 tyrosyl-DNA phosphodiesterase 2 Homo sapiens 51-83 21890891-5 2012 Moreover, these LPS/ficolin-3 complexes activated the lectin pathway of complement in a C4b-deposition assay in a calcium- and magnesium-dependent way. Magnesium 127-136 ficolin 3 Homo sapiens 20-29 22183257-0 2012 Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells. Magnesium 38-47 transient receptor potential cation channel subfamily M member 7 Homo sapiens 10-15 22183257-2 2012 Since microvascular endothelial cells are protagonists in this process, we investigated the behavior of these cells cultured in low extracellular magnesium or silenced for its transporter Transient Receptor Potential Melastatin (TRPM)7, essential for cellular magnesium homeostasis. Magnesium 260-269 transient receptor potential cation channel subfamily M member 7 Homo sapiens 229-235 22183257-4 2012 Silencing TRPM7 mimics the effects of low extracellular magnesium on human microvascular endothelial cells (HMEC). Magnesium 56-65 transient receptor potential cation channel subfamily M member 7 Homo sapiens 10-15 22183257-6 2012 Since low extracellular magnesium markedly decreases TRPM7 in HMEC, we suggest that TRPM7 downregulation might mediate low magnesium-induced inhibition of cell growth and migration. Magnesium 24-33 transient receptor potential cation channel subfamily M member 7 Homo sapiens 53-58 22183257-6 2012 Since low extracellular magnesium markedly decreases TRPM7 in HMEC, we suggest that TRPM7 downregulation might mediate low magnesium-induced inhibition of cell growth and migration. Magnesium 24-33 transient receptor potential cation channel subfamily M member 7 Homo sapiens 84-89 22183257-6 2012 Since low extracellular magnesium markedly decreases TRPM7 in HMEC, we suggest that TRPM7 downregulation might mediate low magnesium-induced inhibition of cell growth and migration. Magnesium 123-132 transient receptor potential cation channel subfamily M member 7 Homo sapiens 84-89 22042551-11 2012 The optimum pH was in the range of 7.5-8 for both APE1s and had an optimal activity at 50-100 mM KCl, and they showed Mg(2+) dependence and abrogation of activity at high salt. Magnesium 118-120 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 50-54 22364157-2 2012 Low magnesium intakes and blood levels have been associated with type 2 diabetes, metabolic syndrome, elevated C-reactive protein, hypertension, atherosclerotic vascular disease, sudden cardiac death, osteoporosis, migraine headache, asthma, and colon cancer. Magnesium 4-13 C-reactive protein Homo sapiens 111-129 22364157-7 2012 Cellular magnesium deficit, perhaps involving TRPM6/7 channels, elicits calcium-activated inflammatory cascades independent of injury or pathogens. Magnesium 9-18 transient receptor potential cation channel subfamily M member 6 Homo sapiens 46-51 22611938-0 2012 [Effects of magnesium intake on expression of insulin receptor in type 2 diabetes rats]. Magnesium 12-21 insulin receptor Rattus norvegicus 46-62 22611938-1 2012 OBJECTIVE: To investigate the effects of magnesium intake on expression of insulin receptor in type 2 diabetes rats. Magnesium 41-50 insulin receptor Rattus norvegicus 75-91 22340148-3 2012 RESULTS: Significant correlations were found between GAF scores and energy (kilocalories), carbohydrates, fibre, total fat, linoleic acid, riboflavin, niacin, folate, vitamin B6, vitamin B12, pantothenic acid, calcium, phosphorus, potassium, and iron (all P values < 0.05), as well as magnesium (r = 0.41, P < 0.001) and zinc (r = 0.35, P < 0.001). Magnesium 288-297 fibroblast growth factor 9 Homo sapiens 53-56 26069820-8 2012 Also examined in this review is the role of magnesium on parathyroid hormone (PTH) levels in dialysis patients. Magnesium 44-53 parathyroid hormone Homo sapiens 57-76 21719932-7 2012 Serum magnesium levels were inversely correlated with body mass index, systolic blood pressure, diastolic blood pressure, waist circumference and fasting insulin levels. Magnesium 6-15 insulin Homo sapiens 154-161 21310790-5 2012 A requirement for an intact Walker A box and the magnesium-co-ordinating aspartate of the classical Walker B box suggest that an initial ATP hydrolysis step is necessary for activation of both NOD1 and NOD2. Magnesium 49-58 nucleotide binding oligomerization domain containing 1 Homo sapiens 193-197 21310790-5 2012 A requirement for an intact Walker A box and the magnesium-co-ordinating aspartate of the classical Walker B box suggest that an initial ATP hydrolysis step is necessary for activation of both NOD1 and NOD2. Magnesium 49-58 nucleotide binding oligomerization domain containing 2 Homo sapiens 202-206 21984552-0 2012 Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg2+, NF-kappaB, and de novo ceramide. Magnesium 11-20 nuclear factor kappa B subunit 1 Homo sapiens 133-142 22332695-0 2012 Proton pump inhibitors are associated with lower magnesium levels in older people with chronic kidney disease. Magnesium 49-58 ATPase H+/K+ transporting subunit alpha Homo sapiens 0-11 22130146-0 2012 Synthesis, structural and hydrogenation properties of Mg-rich MgH2-TiH2 nanocomposites prepared by reactive ball milling under hydrogen gas. Magnesium 54-56 RuvB like AAA ATPase 2 Homo sapiens 67-71 22907037-4 2012 Despite differences in patient populations, some observational and interventional studies have suggested that low serum/dietary magnesium is associated with higher CIMT and more cardiovascular risk factors. Magnesium 128-137 CIMT Homo sapiens 164-168 22907037-9 2012 Potentially promising avenues include the combination of magnesium with a statin to reduce cholesterol, C-reactive protein and CIMT, and its early use to reduce stroke morbidity and mortality. Magnesium 57-66 C-reactive protein Homo sapiens 104-122 22907037-9 2012 Potentially promising avenues include the combination of magnesium with a statin to reduce cholesterol, C-reactive protein and CIMT, and its early use to reduce stroke morbidity and mortality. Magnesium 57-66 CIMT Homo sapiens 127-131 21964343-7 2012 After 48h of MG-2477 exposure, phosphatidylserine externalization on the cell membrane, caspase-3 activation, and PARP cleavage occurred, revealing that apoptotic cell death had begun. Magnesium 13-15 caspase 3 Homo sapiens 88-97 21964343-7 2012 After 48h of MG-2477 exposure, phosphatidylserine externalization on the cell membrane, caspase-3 activation, and PARP cleavage occurred, revealing that apoptotic cell death had begun. Magnesium 13-15 collagen type XI alpha 2 chain Homo sapiens 114-118 21964343-10 2012 Treatment with MG-2477 also reduced phosphorylation of mTOR downstream targets p70 ribosomal S6 kinase and 4E-BP1. Magnesium 15-17 mechanistic target of rapamycin kinase Homo sapiens 55-59 21964343-11 2012 Overexpression of Akt by transfection with a Myr-Akt vector decreased MG-2477 induced autophagy, indicating that Akt is involved. Magnesium 70-72 AKT serine/threonine kinase 1 Homo sapiens 18-21 21964343-11 2012 Overexpression of Akt by transfection with a Myr-Akt vector decreased MG-2477 induced autophagy, indicating that Akt is involved. Magnesium 70-72 AKT serine/threonine kinase 1 Homo sapiens 49-52 21964343-11 2012 Overexpression of Akt by transfection with a Myr-Akt vector decreased MG-2477 induced autophagy, indicating that Akt is involved. Magnesium 70-72 AKT serine/threonine kinase 1 Homo sapiens 49-52 21696337-0 2012 Serum magnesium concentrations in polycystic ovary syndrome and its association with insulin resistance. Magnesium 6-15 insulin Homo sapiens 85-92 22379366-4 2012 Mg is an antioxidant and calcium blocker and in space there is oxidative stress, insulin resistance, and inflammatory conditions with evidence in experimental animals of significant endothelial injuries and damage to mitochondria. Magnesium 0-2 insulin Homo sapiens 81-88 21696337-1 2012 OBJECTIVE: It has been revealed that low serum magnesium (Mg) is often associated with insulin resistance (IR), cardiovascular problems, diabetes mellitus, and hypertension. Magnesium 47-56 insulin Homo sapiens 87-94 22099153-3 2011 In this study we analyzed abundances miRNA-125b and miRNA-146a in magnesium-, iron-, gallium, and aluminum-sulfate-stressed human-astroglial (HAG) cells, a structural and immune-responsive brain cell type. Magnesium 66-75 microRNA 146a Homo sapiens 52-62 22185916-6 2012 The levels of alpha-smooth muscle actin protein and mRNA expression were increased by chronic CCl(4) exposure and Mg-CUD attenuated these increases. Magnesium 114-116 actin gamma 2, smooth muscle Rattus norvegicus 14-39 22518291-4 2012 In addition, lower concentrations of magnesium are associated with oxidative stress, proinflammatory state, endothelial dysfunction, platelet aggregation, insulin resistance, and hyperglycemia. Magnesium 37-46 insulin Homo sapiens 155-162 21914662-0 2012 Establishment of an in planta magnesium monitoring system using CAX3 promoter-luciferase in Arabidopsis. Magnesium 30-39 cation exchanger 3 Arabidopsis thaliana 64-68 21914662-3 2012 Mg deficiency-induced genes were identified by microarray analysis and transgenic lines that expressed luciferase (LUC) under the control of the Mg deficiency-inducible CAX3 promoter were established. Magnesium 0-2 cation exchanger 3 Arabidopsis thaliana 169-173 21914662-5 2012 The CAX3 expression pattern was also examined in a previously characterized low Mg-sensitive mutant, mrs2-7. Magnesium 80-82 cation exchanger 3 Arabidopsis thaliana 4-8 21914662-7 2012 In addition, CAX3 expression was negatively correlated with the shoot Mg concentration. Magnesium 70-72 cation exchanger 3 Arabidopsis thaliana 13-17 21914662-8 2012 Together, these results indicate that CAX3 transcription is a quantitative marker of the Mg status in Arabidopsis. Magnesium 89-91 cation exchanger 3 Arabidopsis thaliana 38-42 22876566-2 2012 Mutations of the transient receptor potential melastatin 6 (TRPM6) gene, which codes for TRPM6, the basic channel for intestinal Mg absorption and a new member of the transient receptor potential (TRP) family of cation channels, result in primary hypomagnesemia. Magnesium 129-131 transient receptor potential cation channel subfamily M member 6 Homo sapiens 17-58 22876566-2 2012 Mutations of the transient receptor potential melastatin 6 (TRPM6) gene, which codes for TRPM6, the basic channel for intestinal Mg absorption and a new member of the transient receptor potential (TRP) family of cation channels, result in primary hypomagnesemia. Magnesium 129-131 transient receptor potential cation channel subfamily M member 6 Homo sapiens 60-65 22876566-2 2012 Mutations of the transient receptor potential melastatin 6 (TRPM6) gene, which codes for TRPM6, the basic channel for intestinal Mg absorption and a new member of the transient receptor potential (TRP) family of cation channels, result in primary hypomagnesemia. Magnesium 129-131 transient receptor potential cation channel subfamily M member 6 Homo sapiens 89-94 22974787-2 2012 TRPM6, TRPM7 and MagT1 are involved in the active transcellular Mg transport processes in intestine and kidney. Magnesium 64-66 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 22974787-2 2012 TRPM6, TRPM7 and MagT1 are involved in the active transcellular Mg transport processes in intestine and kidney. Magnesium 64-66 transient receptor potential cation channel subfamily M member 7 Homo sapiens 7-12 22974787-2 2012 TRPM6, TRPM7 and MagT1 are involved in the active transcellular Mg transport processes in intestine and kidney. Magnesium 64-66 magnesium transporter 1 Homo sapiens 17-22 23387283-9 2012 As Mg is essential for PTH secretion in response to hypocalcemia and to inhibit the K channel activity that controls urinary K excretion, hypomagnesemia can cause hypocalcemia and hypokalemia, which is refractory to repletion therapy unless Mg is administered. Magnesium 3-5 parathyroid hormone Homo sapiens 23-26 22577491-8 2012 Regarding the inter-individual relationships among serum redox statuses and dietary nutrient intakes, significant correlations were noted in CAT versus carbohydrates, protein, magnesium, and manganese; GSH versus carbohydrates, protein, fat, selenium, zinc, iron, and magnesium; XO versus cholesterol; CAT versus GSH. Magnesium 176-185 catalase Homo sapiens 141-144 22577491-8 2012 Regarding the inter-individual relationships among serum redox statuses and dietary nutrient intakes, significant correlations were noted in CAT versus carbohydrates, protein, magnesium, and manganese; GSH versus carbohydrates, protein, fat, selenium, zinc, iron, and magnesium; XO versus cholesterol; CAT versus GSH. Magnesium 268-277 catalase Homo sapiens 141-144 23285003-0 2012 The role of serum magnesium and calcium on the association between adiponectin levels and all-cause mortality in end-stage renal disease patients. Magnesium 18-27 adiponectin, C1Q and collagen domain containing Homo sapiens 67-78 23285003-3 2012 Here, we examined the association of ADPN with serum magnesium (s-Mg) and calcium (s-Ca) levels and explored the possibility whether these two factors could modify the relationship between ADPN and all-cause mortality in patients with end-stage renal disease. Magnesium 53-62 adiponectin, C1Q and collagen domain containing Homo sapiens 37-41 23285003-5 2012 S-Mg and s-Ca levels emerged as positive and negative predictors of ADPN levels, respectively. Magnesium 2-4 adiponectin, C1Q and collagen domain containing Homo sapiens 68-72 23285003-7 2012 There was a significant 4% increased risk for all-cause mortality for each 1-microg/ml increment of ADPN (crude HR, 1.04; 95% CI, 1.01-1.07), even after adjustment for s-Mg and s-Ca levels, dialysis mode, age, albumin and C-reactive protein. Magnesium 170-172 adiponectin, C1Q and collagen domain containing Homo sapiens 100-104 23071810-5 2012 Both cax1 and cax1/cax2 had increased tolerance to Mg stress, while cax2 and cax2/cax3 both had increased sensitivity to Mn stress. Magnesium 51-53 cation exchanger 1 Arabidopsis thaliana 5-9 23071810-5 2012 Both cax1 and cax1/cax2 had increased tolerance to Mg stress, while cax2 and cax2/cax3 both had increased sensitivity to Mn stress. Magnesium 51-53 cation exchanger 1 Arabidopsis thaliana 14-18 23071810-5 2012 Both cax1 and cax1/cax2 had increased tolerance to Mg stress, while cax2 and cax2/cax3 both had increased sensitivity to Mn stress. Magnesium 51-53 cation exchanger 2 Arabidopsis thaliana 19-23 22900022-3 2012 METHODOLOGY/PRINCIPAL FINDINGS: TC10 requires high concentrations of magnesium in order to stabilize guanine nucleotide binding. Magnesium 69-78 ras homolog family member Q Homo sapiens 32-36 22900022-4 2012 Kinetic analysis of this process revealed that magnesium acutely decreased the nucleotide release and exchange rates of TC10, suggesting that the G protein may behave as a rapidly exchanging, and therefore active protein in vivo. Magnesium 47-56 ras homolog family member Q Homo sapiens 120-124 22679498-1 2012 Due to its extreme salinity and high Mg concentration the Dead Sea is characterized by a very low density of cells most of which are Archaea. Magnesium 37-39 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 63-66 22291997-11 2012 Absolute changes in HbA1c independently predicted magnesium changes in the multiple linear regression analysis. Magnesium 50-59 hemoglobin subunit alpha 1 Homo sapiens 20-24 22237213-10 2012 There was a significant positive correlation between serum Mg and serum lipoprotein-a (LP-a) (r = 0.40, P < 0.007), serum HDL (r = 0.31, P < 0.01) and serum TG (r = 0.35, P < 0.005). Magnesium 59-61 lipoprotein(a) Homo sapiens 72-85 22237213-10 2012 There was a significant positive correlation between serum Mg and serum lipoprotein-a (LP-a) (r = 0.40, P < 0.007), serum HDL (r = 0.31, P < 0.01) and serum TG (r = 0.35, P < 0.005). Magnesium 59-61 lipoprotein(a) Homo sapiens 87-91 22237213-14 2012 We conclude that patients with chronic kidney disease undergoing MHD show positive correlation between serum Mg and serum HDL, LP-a and TG. Magnesium 109-111 lipoprotein(a) Homo sapiens 127-131 22642069-7 2012 Contribution of tap water in the intake of calcium and magnesium depended on the contents of these minerals in water, and amounted from 6,0% (< or = 68,3 mg calcium on dm3 water--1st quartile) to 14,8% (> 112 mg/dm3--4th quartile) for calcium and from 2,9% (< or = 10,9 mg/dm3) to 4,7% (> 15,4 mg/dm3) for magnesium. Magnesium 55-64 nuclear RNA export factor 1 Homo sapiens 16-19 22642069-7 2012 Contribution of tap water in the intake of calcium and magnesium depended on the contents of these minerals in water, and amounted from 6,0% (< or = 68,3 mg calcium on dm3 water--1st quartile) to 14,8% (> 112 mg/dm3--4th quartile) for calcium and from 2,9% (< or = 10,9 mg/dm3) to 4,7% (> 15,4 mg/dm3) for magnesium. Magnesium 318-327 nuclear RNA export factor 1 Homo sapiens 16-19 22642069-9 2012 Comparing the average content of minerals in non-boiled and boiled tap water the cooking process influenced the levels of calcium (95,8 +/- 31,8 vs 89,7 +/- 31,1 mg/dm3), magnesium (12,1 +/- 3,24 vs. 12,7 +/- 3,04 mg/dm3), zinc (0,35 +/- 0,87 vs. 0,17 +/- 0,89 mg/dm3), potassium (3,31 +/- 2,67 vs. 3,66 +/- 4,18 mg/dm3) and sodium (23,2 +/- 15,4 vs. 25,9 +/- 17,2 mg/dm3). Magnesium 171-180 nuclear RNA export factor 1 Homo sapiens 67-70 21982822-5 2011 Electrophysiological analyses revealed that the cytoplasmic pore of Kir3.2 selectively binds positively charged molecules and has a higher affinity for Mg(2+) when it has a low probability of being open. Magnesium 152-154 potassium inwardly rectifying channel subfamily J member 6 Homo sapiens 68-74 22110057-3 2011 Evidence is presented that the developing MG is patterned by sequential Ephrin/FGF/MAPK and Delta/Notch signaling events. Magnesium 42-44 ephrin Ciona intestinalis 72-78 27957023-1 2011 BACKGROUND: Proton pump inhibitors (PPIs) cause a sharp elevation of gastro-duodenal luminal pH which in turn has resulted in reports of reduced absorption of magnesium and certain other nutrients. Magnesium 159-168 ATPase H+/K+ transporting subunit alpha Homo sapiens 12-23 21675994-3 2011 Studies have shown that magnesium intake affects the secretion of total IGF-1 and increase testosterone bioactivity. Magnesium 24-33 insulin like growth factor 1 Homo sapiens 72-77 21675994-7 2011 Linear regression models were used to test the relationship between magnesium and testosterone and IGF-1. Magnesium 68-77 insulin like growth factor 1 Homo sapiens 99-104 21675994-9 2011 After adjusting for age, magnesium was positively associated with total testosterone (beta +- SE, 34.9 +- 10.3; p = 0.001) and with total IGF-1 (beta +- SE, 15.9 +- 4.8; p = 0.001). Magnesium 25-34 insulin like growth factor 1 Homo sapiens 138-143 21675994-11 2011 In the multivariate analysis adjusted for age, BMI, log (IL-6), liver function, energy intake, log (insulin), log (DHEAS), selenium, magnesium levels were also still significantly associated with IGF-1 (beta +- SE, 16.43 +- 4.90; p = 0.001) and remained significant after adjusting for total testosterone (beta +- SE, 14.4 +- 4.9; p = 0.01). Magnesium 133-142 insulin like growth factor 1 Homo sapiens 196-201 21675994-12 2011 In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1. Magnesium 26-35 insulin like growth factor 1 Homo sapiens 129-134 21780161-0 2011 Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21(Cip1) and p27(Kip1) in renal epithelial NRK-52E cells. Magnesium 0-9 KRAS proto-oncogene, GTPase Rattus norvegicus 107-110 21780161-0 2011 Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21(Cip1) and p27(Kip1) in renal epithelial NRK-52E cells. Magnesium 0-9 cyclin-dependent kinase inhibitor 1A Rattus norvegicus 111-115 21780161-0 2011 Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21(Cip1) and p27(Kip1) in renal epithelial NRK-52E cells. Magnesium 0-9 cyclin-dependent kinase inhibitor 1B Rattus norvegicus 122-125 21780161-0 2011 Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21(Cip1) and p27(Kip1) in renal epithelial NRK-52E cells. Magnesium 0-9 cyclin-dependent kinase inhibitor 1B Rattus norvegicus 126-130 21780161-11 2011 Together, lack of magnesium may increase p21(Cip1) and p27(Kip1) levels mediated by the decrease in ATP content and the activation of p53, resulting in the suppression of cell cycle progression from G1 to S phase in NRK-52E cells. Magnesium 18-27 KRAS proto-oncogene, GTPase Rattus norvegicus 41-44 21780161-11 2011 Together, lack of magnesium may increase p21(Cip1) and p27(Kip1) levels mediated by the decrease in ATP content and the activation of p53, resulting in the suppression of cell cycle progression from G1 to S phase in NRK-52E cells. Magnesium 18-27 cyclin-dependent kinase inhibitor 1A Rattus norvegicus 45-49 21780161-11 2011 Together, lack of magnesium may increase p21(Cip1) and p27(Kip1) levels mediated by the decrease in ATP content and the activation of p53, resulting in the suppression of cell cycle progression from G1 to S phase in NRK-52E cells. Magnesium 18-27 cyclin-dependent kinase inhibitor 1B Rattus norvegicus 55-58 21780161-11 2011 Together, lack of magnesium may increase p21(Cip1) and p27(Kip1) levels mediated by the decrease in ATP content and the activation of p53, resulting in the suppression of cell cycle progression from G1 to S phase in NRK-52E cells. Magnesium 18-27 cyclin-dependent kinase inhibitor 1B Rattus norvegicus 59-63 21780161-11 2011 Together, lack of magnesium may increase p21(Cip1) and p27(Kip1) levels mediated by the decrease in ATP content and the activation of p53, resulting in the suppression of cell cycle progression from G1 to S phase in NRK-52E cells. Magnesium 18-27 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 134-137 22068124-0 2011 Infusion of Mg in humans acutely reduces serum insulin levels: a pilot study. Magnesium 12-14 insulin Homo sapiens 47-54 22113391-6 2011 Inhibition of the EGFR induces a mutated-like transient receptor potential cation channel, subfamily M, member 6 (TRPM6) syndrome, characterized by urinary magnesium and calcium wasting. Magnesium 156-165 epidermal growth factor receptor Homo sapiens 18-22 22113391-6 2011 Inhibition of the EGFR induces a mutated-like transient receptor potential cation channel, subfamily M, member 6 (TRPM6) syndrome, characterized by urinary magnesium and calcium wasting. Magnesium 156-165 transient receptor potential cation channel subfamily M member 6 Homo sapiens 114-119 22113391-8 2011 It is a reversible toxicity; the recovery of magnesium serum levels is usually seen 4-6 weeks of stopping the anti-EGFR antibody. Magnesium 45-54 epidermal growth factor receptor Homo sapiens 115-119 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Magnesium 66-75 mutS homolog 2 Homo sapiens 18-23 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Magnesium 66-75 mutS homolog 6 Homo sapiens 24-29 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Magnesium 66-75 mutS homolog 6 Homo sapiens 120-125 21937421-3 2011 Destabilization of magnesium results in ADP release from hMSH2 that allows high affinity ATP binding by hMSH6, which then enhances ATP binding by hMSH2. Magnesium 19-28 mutS homolog 2 Homo sapiens 57-62 21937421-3 2011 Destabilization of magnesium results in ADP release from hMSH2 that allows high affinity ATP binding by hMSH6, which then enhances ATP binding by hMSH2. Magnesium 19-28 mutS homolog 6 Homo sapiens 104-109 21937421-3 2011 Destabilization of magnesium results in ADP release from hMSH2 that allows high affinity ATP binding by hMSH6, which then enhances ATP binding by hMSH2. Magnesium 19-28 mutS homolog 2 Homo sapiens 146-151 21926172-0 2011 Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. Magnesium 49-58 transient receptor potential cation channel subfamily M member 7 Homo sapiens 78-119 21926172-0 2011 Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. Magnesium 49-58 transient receptor potential cation channel subfamily M member 7 Homo sapiens 121-126 21926172-1 2011 Transient receptor potential melastatin 7 (TRPM7) channels represent the major magnesium-uptake mechanism in mammalian cells and are key regulators of cell growth and proliferation. Magnesium 79-88 transient receptor potential cation channel subfamily M member 7 Homo sapiens 0-41 21926172-1 2011 Transient receptor potential melastatin 7 (TRPM7) channels represent the major magnesium-uptake mechanism in mammalian cells and are key regulators of cell growth and proliferation. Magnesium 79-88 transient receptor potential cation channel subfamily M member 7 Homo sapiens 43-48 21926172-6 2011 Mutating a Mg(2+) binding site on the TRPM7 kinase domain reduced the potency of the compound, whereas kinase deletion enhanced its efficacy independent of Mg(2+). Magnesium 11-13 transient receptor potential cation channel subfamily M member 7 Homo sapiens 38-43 21221836-0 2011 Intra-erythrocyte magnesium is associated with gamma-glutamyl transferase in obese children and adolescents. Magnesium 18-27 gamma-glutamyltransferase 1 Homo sapiens 47-73 21864896-2 2011 In the present study, we have synthesized biodegradable calcium/magnesium-doped silica-based scaffolds with hierarchically macro/mesoporous structure (CMMS), and incorporated recombinant human bone morphogenetic protein-2 (rhBMP-2) into the scaffolds to obtain a hybrid system for osteogenic factor delivery in the functional repair of bone defects. Magnesium 64-73 bone morphogenetic protein 2 Homo sapiens 193-221 21803600-5 2011 The independent correlates of serum resistin levels in patients with cervical HF were serum osteocalcin and magnesium (both negatively associated) and in patients with trochanteric HF, serum PTH, calcium and age (all positively associated). Magnesium 108-117 resistin Homo sapiens 36-44 21810903-4 2011 In excised inside-out patch-clamp measurements, ATP reactivated the human TRPV6 channels after current rundown only in the presence of Mg(2+). Magnesium 135-137 transient receptor potential cation channel subfamily V member 6 Homo sapiens 74-79 21594582-9 2011 After administration of magnesium, bone marker levels were increased, and TmP/GFR was reduced to normal levels, despite the persistent elevation of PTH. Magnesium 24-33 Rap guanine nucleotide exchange factor 5 Homo sapiens 74-81 21594582-9 2011 After administration of magnesium, bone marker levels were increased, and TmP/GFR was reduced to normal levels, despite the persistent elevation of PTH. Magnesium 24-33 parathyroid hormone Homo sapiens 148-151 22051430-7 2011 Preliminary evidence suggests that insulin sensitivity, hyperglycemia, diabetes mellitus, left ventricular hypertrophy, and dyslipidemia may be improved with increased magnesium intake. Magnesium 168-177 insulin Homo sapiens 35-42 20838396-2 2011 In this process, we found that in the CMYA5 gene, there were two non-synonymous markers, rs3828611 and rs10043986, showing nominal significance in both the CATIE and MGS-GAIN samples. Magnesium 166-169 cardiomyopathy associated 5 Homo sapiens 38-43 21936511-1 2011 Using the minima hopping global geometry optimization method on density functional potential energy surface, we have studied the structural and electronic properties of magnesium clusters for a size range of Mg(N) where N = 10-56. Magnesium 169-178 helt bHLH transcription factor Homo sapiens 208-213 21936511-1 2011 Using the minima hopping global geometry optimization method on density functional potential energy surface, we have studied the structural and electronic properties of magnesium clusters for a size range of Mg(N) where N = 10-56. Magnesium 169-178 nuclear receptor subfamily 4 group A member 1 Homo sapiens 220-226 21177272-6 2011 Although both LiF:Mg,Ti and CaF(2):Dy TLDs showed a strong response to (222)Rn, the badges prevented measurable radon detection by the TLDs within. Magnesium 18-20 LIF interleukin 6 family cytokine Homo sapiens 14-17 21875085-11 2011 Magnesium ions may serve as a physiological cofactor with calcium for NCS-1-D2R binding. Magnesium 0-9 neuronal calcium sensor 1 Homo sapiens 70-75 22059076-0 2011 Engineering Parvalbumin for the Heart: Optimizing the Mg Binding Properties of Rat beta-Parvalbumin. Magnesium 54-56 parvalbumin Rattus norvegicus 12-23 22059076-0 2011 Engineering Parvalbumin for the Heart: Optimizing the Mg Binding Properties of Rat beta-Parvalbumin. Magnesium 54-56 parvalbumin Rattus norvegicus 88-99 22059076-1 2011 Parvalbumin (PV), an EF-hand protein family member, is a delayed calcium buffer that exchanges magnesium for calcium to facilitate fast skeletal muscle relaxation. Magnesium 95-104 parvalbumin Rattus norvegicus 0-11 22016520-7 2011 In intact animals, elevation of brain magnesium increased NMDA receptors (NMDARs) signaling, BDNF expression, density of presynaptic puncta, and synaptic plasticity in the PFC but, interestingly, not in the basolateral amygdala. Magnesium 38-47 brain-derived neurotrophic factor Rattus norvegicus 93-97 21729692-6 2011 In addition, we demonstrate that the activity of MIPS from Arabidopsis thaliana is moderately enhanced by the addition Mg(2+) and is not enhanced by other divalent metal ions (Zn(2+) and Mn(2+)), consistent with what has been observed for other eukaryotic MIPS enzymes. Magnesium 119-121 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 49-53 21705076-11 2011 Briefly, Ca, Mg and Si ions extracted from akermanite in the concentrations of 2.36, 1.11, 1.03 mM, respectively, could facilitate the osteogenic differentiation of hASCs via an ERK pathway, and suppress the proliferation of hASCs without significant cytotoxicity. Magnesium 13-15 mitogen-activated protein kinase 1 Homo sapiens 178-181 21696366-4 2011 Consistent with this conclusion, structure-function analyses of heterologous SLC41A1 transporter expression demonstrate that SLC41A1 transporters exhibit the same plasma membrane orientation as homologous bacterial MgtE proteins, are capable of complementing growth of TRPM7-deficient cells only when the Mg(2+) transporting pore is intact, and require an N-terminal cytoplasmic domain for Mg(2+)-dependent regulation of lysosomal degradation and surface expression. Magnesium 215-217 solute carrier family 41 member 1 Homo sapiens 125-132 21736832-0 2011 Hepcidin expression in the liver of rats fed a magnesium-deficient diet. Magnesium 47-56 hepcidin antimicrobial peptide Rattus norvegicus 0-8 21736832-2 2011 In the present study, we examined the gene expression of Hepcidin, a peptide hormone produced in the liver to regulate intestinal Fe absorption negatively, in Mg-deficient rats. Magnesium 159-161 hepcidin antimicrobial peptide Rattus norvegicus 57-65 21858842-0 2011 Magnesium deficiency up-regulates Myod expression in rat skeletal muscle and C2C12 myogenic cells. Magnesium 0-9 myogenic differentiation 1 Mus musculus 34-38 21858842-5 2011 In vivo effects of Mg deficiency on myogenic gene expression were partially reproduced in in vitro C2C12 cells; expression of Myod was up-regulated by a mixed culture of myoblasts and myotubes with Mg-deficient medium, which related to the simultaneous up-regulation of Myhc IIb, a myotube-specific protein. Magnesium 19-21 myogenic differentiation 1 Mus musculus 126-130 21858842-5 2011 In vivo effects of Mg deficiency on myogenic gene expression were partially reproduced in in vitro C2C12 cells; expression of Myod was up-regulated by a mixed culture of myoblasts and myotubes with Mg-deficient medium, which related to the simultaneous up-regulation of Myhc IIb, a myotube-specific protein. Magnesium 19-21 myosin, heavy polypeptide 4, skeletal muscle Mus musculus 270-278 22400262-5 2011 The LDH incorporating magnesium or calcium divalent cations present high-quality surface topology for DAO immobilization and the ability to keep the enzyme in a well conformation for biogenic amines catabolism and histamine detection. Magnesium 22-31 amine oxidase copper containing 1 Homo sapiens 102-105 21620965-7 2011 After incubation with EDTA, addition of Mn(++) or Mg(++) caused reversion of Band 1 to a Band 2/Band 3 PDE5 mixture in which Band 3 PDE5 predominated. Magnesium 50-56 phosphodiesterase 5A Homo sapiens 103-107 21620965-7 2011 After incubation with EDTA, addition of Mn(++) or Mg(++) caused reversion of Band 1 to a Band 2/Band 3 PDE5 mixture in which Band 3 PDE5 predominated. Magnesium 50-56 phosphodiesterase 5A Homo sapiens 132-136 21821372-0 2011 The association of serum C-reactive protein, uric acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes. Magnesium 59-68 insulin Homo sapiens 74-81 21540113-2 2011 This viral ATPase contains four known functional motifs (motifs I-IV) and a novel AYDG motif; they are essential for ATP hydrolysis reaction by binding ATP and magnesium ions. Magnesium 160-169 dynein axonemal heavy chain 8 Homo sapiens 11-17 21540113-8 2011 Divalent ions such as magnesium and calcium were essential for ATPase activity. Magnesium 22-31 dynein axonemal heavy chain 8 Homo sapiens 63-69 21940450-8 2011 In addition, we found that, like other members of the TRPM subfamily, TRPM1 current is susceptible to voltage-independent inhibition by intracellular magnesium, and that modulation by PKCalpha relieves this inhibition, as the potentiating effects of OAG are absent in low intracellular magnesium. Magnesium 150-159 transient receptor potential cation channel, subfamily M, member 1 Mus musculus 70-75 21940450-8 2011 In addition, we found that, like other members of the TRPM subfamily, TRPM1 current is susceptible to voltage-independent inhibition by intracellular magnesium, and that modulation by PKCalpha relieves this inhibition, as the potentiating effects of OAG are absent in low intracellular magnesium. Magnesium 286-295 transient receptor potential cation channel, subfamily M, member 1 Mus musculus 70-75 21940450-8 2011 In addition, we found that, like other members of the TRPM subfamily, TRPM1 current is susceptible to voltage-independent inhibition by intracellular magnesium, and that modulation by PKCalpha relieves this inhibition, as the potentiating effects of OAG are absent in low intracellular magnesium. Magnesium 286-295 protein kinase C, alpha Mus musculus 184-192 21940450-9 2011 We conclude that activation of PKCalpha initiates a modulatory mechanism at the rod-rod bipolar cell synapse whose function is to reduce inhibition of the TRPM1 current by magnesium, thereby increasing the gain of transmission at this synapse. Magnesium 172-181 protein kinase C, alpha Mus musculus 31-39 21940450-9 2011 We conclude that activation of PKCalpha initiates a modulatory mechanism at the rod-rod bipolar cell synapse whose function is to reduce inhibition of the TRPM1 current by magnesium, thereby increasing the gain of transmission at this synapse. Magnesium 172-181 transient receptor potential cation channel, subfamily M, member 1 Mus musculus 155-160 21762700-7 2011 Interestingly, both the endoribonuclease and the ssRNA AP site cleavage activities of WT APE1 were present in the absence of Mg(2+), while ssDNA AP site cleavage required Mg(2+) (optimally at 0.5-2.0 mM). Magnesium 125-127 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 89-93 21653632-1 2011 Renal magnesium (Mg(2+)) and sodium (Na(+)) loss are well-known side effects of cyclosporine (CsA) treatment in humans, but the underlying mechanisms still remain unclear. Magnesium 6-15 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 94-97 21488144-1 2011 BACKGROUND: Magnesium modulates insulin-mediated glucose uptake but data regarding its role in insulin secretion are scarce; therefore, in this study we determined whether decreased serum magnesium levels are associated with the impairment of insulin secretion in non-diabetic individuals. Magnesium 12-21 insulin Homo sapiens 32-39 21945443-3 2011 The yeast transformants expressing AtCCX5 were created and their growth in the presence of various cations (K(+), Na(+), Ca(2+), Mg(2+), Fe(2+), Cu(2+), Co(2+), Cd(2+), Mn(2+), Ba(2+), Ni(2+), Zn(2+), and Li(+)) were analyzed. Magnesium 129-131 cation exchanger 11 Arabidopsis thaliana 35-41 21947671-0 2011 MagT1: a highly specific magnesium channel with important roles beyond cellular magnesium homeostasis. Magnesium 25-34 magnesium transporter 1 Homo sapiens 0-5 21947671-3 2011 Among these novel channels, MagT1 has gained most of the attention, given its high selectivity for Mg(2+) and its possible involvement in cellular functions reaching far beyond magnesium homeostasis, as the latest findings seem to imply. Magnesium 99-101 magnesium transporter 1 Homo sapiens 28-33 21947671-3 2011 Among these novel channels, MagT1 has gained most of the attention, given its high selectivity for Mg(2+) and its possible involvement in cellular functions reaching far beyond magnesium homeostasis, as the latest findings seem to imply. Magnesium 177-186 magnesium transporter 1 Homo sapiens 28-33 21951649-6 2011 Immunohistochemical and western blot analyses confirmed that rat mammary tissues express TRPM6 protein levels similar to those found in the kidney, and that protein expression is modulated by dietary Mg(2+). Magnesium 200-202 transient receptor potential cation channel, subfamily M, member 6 Rattus norvegicus 89-94 21341336-6 2011 Moreover, pretreatment of CsA, a cyclophilin D ligand that inhibits mitochondria potential uncoupling, prevented the activation of caspase-9 and caspase-3, but not caspase-8, and the apoptosis of MG-63 cells, triggered by corosolic acid. Magnesium 196-198 peptidylprolyl isomerase D Homo sapiens 33-46 21341336-6 2011 Moreover, pretreatment of CsA, a cyclophilin D ligand that inhibits mitochondria potential uncoupling, prevented the activation of caspase-9 and caspase-3, but not caspase-8, and the apoptosis of MG-63 cells, triggered by corosolic acid. Magnesium 196-198 caspase 9 Homo sapiens 131-140 21569135-7 2011 Magnesium binding induces the rearrangement of some residues around the active site of CKI1(RD) , as was determined by both X-ray crystallography and NMR spectroscopy. Magnesium 0-9 casein kinase I Arabidopsis thaliana 87-95 21670148-5 2011 These defects are accompanied by a significant reduction in integrin beta1 protein levels due to accelerated degradation through an MG-132-sensitive proteasomal pathway. Magnesium 132-134 integrin subunit beta 1 Homo sapiens 60-74 21732644-2 2011 With more nucleophilic RMgCl species (R = Bu, i-Pr, Ph) both nucleophilic addition-elimination at C-4 and bromine-magnesium exchange at C-5 occurred. Magnesium 114-123 complement C5 Homo sapiens 136-139 21739987-2 2011 The measurement of the UV-vis absorption spectrum of alpha-tocopheroxyl (alpha-Toc( )) radical was performed by reacting aroxyl (ArO( )) radical with alpha-tocopherol (alpha-TocH) in acetonitrile solution including four kinds of alkali and alkaline earth metal salts (MX or MX(2)) (LiClO(4), LiI, NaClO(4), and Mg(ClO(4))(2)), using stopped-flow spectrophotometry. Magnesium 311-313 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 129-132 21747282-1 2011 In rodents with dietary magnesium deficiency (Mg deficiency), hypomagnesemia, occurs leading to a rise in circulating substance P from neuronal tissues to trigger systemic inflammatory stress in cardiac and intestinal tissues. Magnesium 24-33 tachykinin precursor 1 Homo sapiens 118-129 21775096-8 2011 The levels of Grp78 and capase-12 mRNA, Grp78 and caspase-12 protein in the MG-132 groups were higher than in the control group (P<0.01). Magnesium 76-78 heat shock protein family A (Hsp70) member 5 Homo sapiens 14-19 21801348-13 2011 Decreased levels of P1NP were observed in TE-85 and MG-63 after GLP-1, GLP-2 and OB. Magnesium 52-54 glucagon like peptide 1 receptor Homo sapiens 64-69 21714500-0 2011 Binding of calcium, magnesium, and target peptides to Cdc31, the centrin of yeast Saccharomyces cerevisiae. Magnesium 20-29 centrin Saccharomyces cerevisiae S288C 54-59 21627970-5 2011 Furthermore, overexpression of MagT1 in TRPM7(-/-) cells augments their capacity to uptake Mg(2+), and improves their growth behavior in the absence of excess Mg(2+). Magnesium 91-93 transient receptor potential cation channel subfamily M member 7 Gallus gallus 40-45 21270092-4 2011 In addition, we discuss a study reporting on the regulation of the mammalian potassium kidney channel ROMK by intracellular and extracellular magnesium, which may be important in the pathogenesis of persistent hypokalemia in patients with concomitant potassium and magnesium deficiency. Magnesium 142-151 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 102-106 21614594-2 2011 In this study, fluorine ions are incorporated into magnesium-containing hydroxyapatite coatings (MgF(y)HA) via sol-gel method to improve the long-term stability of the implants. Magnesium 51-60 signal transducer and activator of transcription 5A Homo sapiens 97-100 21115601-0 2011 Early magnesium modifications as a surrogate marker of efficacy of cetuximab-based anticancer treatment in KRAS wild-type advanced colorectal cancer patients. Magnesium 6-15 KRAS proto-oncogene, GTPase Homo sapiens 107-111 21262274-0 2011 Insights into modulation of calcium signaling by magnesium in calmodulin, troponin C and related EF-hand proteins. Magnesium 49-58 calmodulin 1 Homo sapiens 62-72 21187142-3 2011 Incubation of PDE5 with Mg(++) or Mn(++), which is known to stimulate activity, caused a similar shift of the enzyme from Band 2 to Band 3 as did cGMP or sildenafil, but incubation with EDTA caused a time- and concentration-dependent shift to higher mobility (shift of Bands 2 and 3 to Band 1). Magnesium 24-30 phosphodiesterase 5A Homo sapiens 14-18 21406963-6 2011 Mean methylation of the Hsd11b2 promoter in the Mg-deficient offspring (33.2%) was higher than in controls (10.4%). Magnesium 48-50 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 24-31 21261624-0 2011 Magnesium transporters, MGT2/MRS2-1 and MGT3/MRS2-5, are important for magnesium partitioning within Arabidopsis thaliana mesophyll vacuoles. Magnesium 71-80 magnesium transporter 2 Arabidopsis thaliana 24-28 21261624-0 2011 Magnesium transporters, MGT2/MRS2-1 and MGT3/MRS2-5, are important for magnesium partitioning within Arabidopsis thaliana mesophyll vacuoles. Magnesium 71-80 magnesium transporter 2 Arabidopsis thaliana 29-35 21261624-0 2011 Magnesium transporters, MGT2/MRS2-1 and MGT3/MRS2-5, are important for magnesium partitioning within Arabidopsis thaliana mesophyll vacuoles. Magnesium 71-80 magnesium transporter 3 Arabidopsis thaliana 40-44 21261624-0 2011 Magnesium transporters, MGT2/MRS2-1 and MGT3/MRS2-5, are important for magnesium partitioning within Arabidopsis thaliana mesophyll vacuoles. Magnesium 71-80 magnesium transporter 3 Arabidopsis thaliana 45-51 21261624-4 2011 Specifically, AtMGT2/AtMRS2-1 and AtMGT3/AtMRS2-5 were shown to be targeted to the tonoplast and corresponding T-DNA insertion lines had perturbed mesophyll-specific vacuolar magnesium accumulation under serpentine conditions. Magnesium 175-184 magnesium transporter 2 Arabidopsis thaliana 14-20 21261624-4 2011 Specifically, AtMGT2/AtMRS2-1 and AtMGT3/AtMRS2-5 were shown to be targeted to the tonoplast and corresponding T-DNA insertion lines had perturbed mesophyll-specific vacuolar magnesium accumulation under serpentine conditions. Magnesium 175-184 magnesium transporter 2 Arabidopsis thaliana 21-29 21261624-4 2011 Specifically, AtMGT2/AtMRS2-1 and AtMGT3/AtMRS2-5 were shown to be targeted to the tonoplast and corresponding T-DNA insertion lines had perturbed mesophyll-specific vacuolar magnesium accumulation under serpentine conditions. Magnesium 175-184 magnesium transporter 3 Arabidopsis thaliana 34-40 21261624-4 2011 Specifically, AtMGT2/AtMRS2-1 and AtMGT3/AtMRS2-5 were shown to be targeted to the tonoplast and corresponding T-DNA insertion lines had perturbed mesophyll-specific vacuolar magnesium accumulation under serpentine conditions. Magnesium 175-184 magnesium transporter 3 Arabidopsis thaliana 41-49 21345721-7 2011 In addition, the effect of some metal ions Cu(2+), Ca(2+), Mg(2+), and Zn(2+) on the binding constant between SAS and BSA was examined. Magnesium 59-61 tetraspanin 31 Homo sapiens 110-113 21345721-7 2011 In addition, the effect of some metal ions Cu(2+), Ca(2+), Mg(2+), and Zn(2+) on the binding constant between SAS and BSA was examined. Magnesium 59-61 albumin Homo sapiens 118-121 21592965-1 2011 Biotin carboxylase (BC) activity is shared among biotin-dependent carboxylases and catalyzes the Mg-ATP-dependent carboxylation of biotin using bicarbonate as the CO(2) donor. Magnesium 97-99 methylcrotonyl-CoA carboxylase subunit 2 Homo sapiens 0-18 21592965-1 2011 Biotin carboxylase (BC) activity is shared among biotin-dependent carboxylases and catalyzes the Mg-ATP-dependent carboxylation of biotin using bicarbonate as the CO(2) donor. Magnesium 97-99 methylcrotonyl-CoA carboxylase subunit 2 Homo sapiens 20-22 21592965-4 2011 Two structures are wild-type BC in complex with two ADP molecules and two Ca(2+) ions or two ADP molecules and one Mg(2+) ion. Magnesium 115-117 methylcrotonyl-CoA carboxylase subunit 2 Homo sapiens 29-31 21496075-1 2011 REASONS FOR PERFORMING STUDY: Obesity and insulin resistance are risk factors for laminitis in equids and supplements containing chromium and magnesium might improve insulin sensitivity. Magnesium 142-151 INS Equus caballus 42-49 21496075-1 2011 REASONS FOR PERFORMING STUDY: Obesity and insulin resistance are risk factors for laminitis in equids and supplements containing chromium and magnesium might improve insulin sensitivity. Magnesium 142-151 INS Equus caballus 166-173 21496075-2 2011 HYPOTHESIS: A supplement containing chromium, magnesium and other nutraceuticals would alter morphometric measurements, blood variables, and insulin sensitivity in laminitic obese horses. Magnesium 46-55 INS Equus caballus 141-148 21525006-4 2011 Here, we disclose that ATP and Mg(2+) (ATP/Mg) promote the self-polymerization of chloroplast 2-Cys Prx (polypeptide 23.5 kDa) into soluble higher order assemblies (>2 MDa) that proceed to insoluble aggregates beyond 5 mM ATP. Magnesium 31-33 periaxin Homo sapiens 100-103 21212164-8 2011 RESULTS: Lower serum magnesium was independently associated with PWV (P = 0.018) in addition to age, CRP, HR, diabetes and mean arterial pressure (model R(2) = 0.45; P < 0.001). Magnesium 21-30 C-reactive protein Homo sapiens 101-104 21524996-7 2011 High resolution crystallographic structure analysis further confirmed that the Mn-bound ILK adopts the same pseudo active site conformation as that of the Mg-bound ILK. Magnesium 155-157 integrin linked kinase Homo sapiens 88-91 21524996-7 2011 High resolution crystallographic structure analysis further confirmed that the Mn-bound ILK adopts the same pseudo active site conformation as that of the Mg-bound ILK. Magnesium 155-157 integrin linked kinase Homo sapiens 164-167 21487014-0 2011 Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro. Magnesium 45-54 transient receptor potential cation channel, subfamily M, member 7 Rattus norvegicus 59-100 21487014-0 2011 Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro. Magnesium 45-54 transient receptor potential cation channel, subfamily M, member 7 Rattus norvegicus 102-107 21487014-2 2011 This study aimed to explore whether magnesium was transported via a TRPM7 channel into the intracellular space of rat hippocampal neurons after 1 h of oxygen-glucose deprivation (OGD) and acute chemical ischemia (CI) by using methods of the Mg(2+) fluorescent probe Mag-Fura-2 to detect intracellular magnesium concentration ([Mg(2+)](i)) and flame atomic absorption spectrometry to measure extracellular magnesium concentration ([Mg(2+)](o)). Magnesium 36-45 transient receptor potential cation channel, subfamily M, member 7 Rattus norvegicus 68-73 21487014-2 2011 This study aimed to explore whether magnesium was transported via a TRPM7 channel into the intracellular space of rat hippocampal neurons after 1 h of oxygen-glucose deprivation (OGD) and acute chemical ischemia (CI) by using methods of the Mg(2+) fluorescent probe Mag-Fura-2 to detect intracellular magnesium concentration ([Mg(2+)](i)) and flame atomic absorption spectrometry to measure extracellular magnesium concentration ([Mg(2+)](o)). Magnesium 301-310 transient receptor potential cation channel, subfamily M, member 7 Rattus norvegicus 68-73 21487014-2 2011 This study aimed to explore whether magnesium was transported via a TRPM7 channel into the intracellular space of rat hippocampal neurons after 1 h of oxygen-glucose deprivation (OGD) and acute chemical ischemia (CI) by using methods of the Mg(2+) fluorescent probe Mag-Fura-2 to detect intracellular magnesium concentration ([Mg(2+)](i)) and flame atomic absorption spectrometry to measure extracellular magnesium concentration ([Mg(2+)](o)). Magnesium 301-310 transient receptor potential cation channel, subfamily M, member 7 Rattus norvegicus 68-73 21487014-8 2011 By silencing TRPM7 with shRNA in hippocampal neurons, it was found that not only was the increase of [Mg(2+)](i) induced by OGD or CI but also the basal levels of [Mg(2+)](i) were attenuated. Magnesium 102-104 transient receptor potential cation channel, subfamily M, member 7 Rattus norvegicus 13-18 21401523-6 2011 In particular, calcium and magnesium are recognized by proteins with markedly different binding affinities and cause significantly different conformational changes and stabilization effects in the binding proteins (as in the fifth ligand binding repeat of the LDL receptor binding domain, calcium-binding protein 1, or parvalbumin). Magnesium 27-36 calcium binding protein 1 Homo sapiens 289-314 21401523-6 2011 In particular, calcium and magnesium are recognized by proteins with markedly different binding affinities and cause significantly different conformational changes and stabilization effects in the binding proteins (as in the fifth ligand binding repeat of the LDL receptor binding domain, calcium-binding protein 1, or parvalbumin). Magnesium 27-36 parvalbumin Homo sapiens 319-330 22235507-0 2011 To study various concentrations of magnesium and aluminium on amylin hormone conformation. Magnesium 35-44 islet amyloid polypeptide Homo sapiens 62-68 22235507-3 2011 The aim of this study was to investigate whether different concentrations of magnesium and aluminium alter amylin conformation under near-physiological circumstances. Magnesium 77-86 islet amyloid polypeptide Homo sapiens 107-113 22235507-5 2011 This in vitro study showed that magnesium had contradictory effects on amylin folding and these effects were magnesium concentration dependent. Magnesium 32-41 islet amyloid polypeptide Homo sapiens 71-77 22235507-5 2011 This in vitro study showed that magnesium had contradictory effects on amylin folding and these effects were magnesium concentration dependent. Magnesium 109-118 islet amyloid polypeptide Homo sapiens 71-77 21506533-1 2011 The extracellular signal-regulated protein kinase, ERK2, fully activated by phosphorylation and without a His(6) tag, shows little tendency to dimerize with or without either calcium or magnesium ions when analyzed by light scattering or analytical ultracentrifugation. Magnesium 186-195 mitogen-activated protein kinase 1 Homo sapiens 51-55 21276780-0 2011 NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2. Magnesium 53-62 aldehyde dehydrogenase 2 family member Homo sapiens 71-76 21460229-4 2011 Here, we describe the molecular bases for the md- and mg-dependent rescue of the A(y) phenotype at the MC4R. Magnesium 54-56 melanocortin 4 receptor Mus musculus 103-107 21538606-2 2011 COMT catalyzes the transfer of an activated methyl group from S-adenosylmethionine (SAM) to its catechol substrates, such as L-dopa, in the presence of magnesium ions. Magnesium 152-161 catechol-O-methyltransferase Homo sapiens 0-4 21381700-5 2011 Herein, we show that a designed intramolecular version of the 11-bp core sequence of the said targets, which also constitutes an integral, short, and symmetrical segment (G(2)AG(5)AG(2)) (C(2)TC(5)TC(2)) of human c-jun protooncogene forms a stable triplex, even in the absence of magnesium. Magnesium 280-289 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 213-218 21402051-5 2011 An increase in G6Pase activity was also observed in liver microsomes from rats starved overnight, which presented a ~15% decrease in hepatic Mg(2+) content. Magnesium 141-143 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 15-21 21396942-5 2011 These structures reveal the structural basis for the allosteric activation of cN-II, uncovering a mechanism where an effector-induced disorder-to-order transition generates rearrangements within the catalytic site and the subsequent coordination of the catalytically essential magnesium. Magnesium 277-286 5'-nucleotidase, cytosolic II Homo sapiens 78-83 21565702-0 2011 Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis. Magnesium 67-76 cyclin dependent kinase 2 Homo sapiens 117-121 21499287-9 2011 MG-132 (18.5 mumol/L) suppressed the proteasome activity by about 70% at 3 h. It induced apoptosis via down-regulation of antiapoptotic proteins Bcl-2 and XIAP, up-regulation of pro-apoptotic protein Bax and caspase-3, and production of cleaved C-terminal 85 kDa PARP). Magnesium 0-2 BCL2 apoptosis regulator Homo sapiens 145-150 21499287-9 2011 MG-132 (18.5 mumol/L) suppressed the proteasome activity by about 70% at 3 h. It induced apoptosis via down-regulation of antiapoptotic proteins Bcl-2 and XIAP, up-regulation of pro-apoptotic protein Bax and caspase-3, and production of cleaved C-terminal 85 kDa PARP). Magnesium 0-2 X-linked inhibitor of apoptosis Homo sapiens 155-159 21499287-9 2011 MG-132 (18.5 mumol/L) suppressed the proteasome activity by about 70% at 3 h. It induced apoptosis via down-regulation of antiapoptotic proteins Bcl-2 and XIAP, up-regulation of pro-apoptotic protein Bax and caspase-3, and production of cleaved C-terminal 85 kDa PARP). Magnesium 0-2 BCL2 associated X, apoptosis regulator Homo sapiens 200-203 21499287-9 2011 MG-132 (18.5 mumol/L) suppressed the proteasome activity by about 70% at 3 h. It induced apoptosis via down-regulation of antiapoptotic proteins Bcl-2 and XIAP, up-regulation of pro-apoptotic protein Bax and caspase-3, and production of cleaved C-terminal 85 kDa PARP). Magnesium 0-2 caspase 3 Homo sapiens 208-217 21499287-9 2011 MG-132 (18.5 mumol/L) suppressed the proteasome activity by about 70% at 3 h. It induced apoptosis via down-regulation of antiapoptotic proteins Bcl-2 and XIAP, up-regulation of pro-apoptotic protein Bax and caspase-3, and production of cleaved C-terminal 85 kDa PARP). Magnesium 0-2 collagen type XI alpha 2 chain Homo sapiens 263-267 21270092-4 2011 In addition, we discuss a study reporting on the regulation of the mammalian potassium kidney channel ROMK by intracellular and extracellular magnesium, which may be important in the pathogenesis of persistent hypokalemia in patients with concomitant potassium and magnesium deficiency. Magnesium 265-274 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 102-106 21241290-0 2011 Magnesium improves the beta-cell function to compensate variation of insulin sensitivity: double-blind, randomized clinical trial. Magnesium 0-9 insulin Homo sapiens 69-76 21482872-8 2011 There was also a significant correlation between MG expression grade and CD45 cell infiltration (r = 0.414; P = .05). Magnesium 49-51 protein tyrosine phosphatase receptor type C Homo sapiens 73-77 21296886-2 2011 SLC25A25 is thought to control ATP homeostasis by functioning as a Ca(2+)-regulated shuttle of ATP-Mg(2+) and P(i) across the inner mitochondrial membrane. Magnesium 99-101 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Mus musculus 0-8 21406976-2 2011 In our article1 we provide evidence that two Mg ( 2+) -dependent phosphatidic acid phosphatase enzymes, called PAH1 and PAH2, are capable of repressing phospholipid biosynthesis at the endoplasmic reticulum in Arabidopsis thaliana. Magnesium 45-47 Lipin family protein Arabidopsis thaliana 111-115 21406976-2 2011 In our article1 we provide evidence that two Mg ( 2+) -dependent phosphatidic acid phosphatase enzymes, called PAH1 and PAH2, are capable of repressing phospholipid biosynthesis at the endoplasmic reticulum in Arabidopsis thaliana. Magnesium 45-47 phosphatidic acid phosphohydrolase 2 Arabidopsis thaliana 120-124 21252222-6 2011 4-Hydroxynonenal, an oxidized prostaglandin J(2), and 9- or 10-nitrooleate caused a significant inhibition of ALDH-2 activity, which was improved in the presence of Mg(2+) and Ca(2+). Magnesium 165-167 aldehyde dehydrogenase 2 family member Homo sapiens 110-116 21291896-0 2011 Deficiency of calcium and magnesium induces apoptosis via scavenger receptor BI. Magnesium 26-35 scavenger receptor class B member 1 Cricetulus griseus 58-79 21291896-5 2011 In this study, we assessed our hypothesis that the deficiency of calcium/magnesium induces apoptosis via SR-BI apoptotic pathway. Magnesium 73-82 scavenger receptor class B member 1 Cricetulus griseus 105-110 21291896-11 2011 KEY FINDINGS: The deficiency of calcium/magnesium induced cell apoptosis in CHO-SR-BI cells, but not in CHO-vector cells. Magnesium 40-49 scavenger receptor class B member 1 Cricetulus griseus 80-85 21291896-13 2011 Furthermore, the restoration of calcium or magnesium, but not zinc, protected CHO-SR-BI cells from apoptotic cell death, in a dose-dependent fashion. Magnesium 43-52 scavenger receptor class B member 1 Cricetulus griseus 82-87 21177861-6 2011 Furthermore, magnesium competes with calcium for binding to calreticulin and reduces thermostability. Magnesium 13-22 calreticulin Homo sapiens 60-72 21397062-8 2011 The mutations found in CNNM2, its observed sensitivity to extracellular Mg(2+), and its basolateral localization signify a critical role for CNNM2 in epithelial Mg(2+) transport. Magnesium 72-74 cyclin and CBS domain divalent metal cation transport mediator 2 Homo sapiens 23-28 21354393-0 2011 Modulation of Kir1.1 inactivation by extracellular Ca and Mg. Magnesium 58-60 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 14-20 21354393-1 2011 Kir1.1 inactivation, associated with transient internal acidification, is strongly dependent on external K, Ca, and Mg. Magnesium 116-118 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 0-6 21354393-9 2011 Extracellular Ca and Mg probably potentiate the slow, K-dependent inactivation of Kir1.1 by decreasing the affinity of the channel for external K independently of divalent block. Magnesium 21-23 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 82-88 21354393-10 2011 The removal of external Ca and Mg largely eliminated both Kir1.1 inactivation and the K-dependence of pH gating, thereby uncoupling the selectivity filter gate from the cytoplasmic-side bundle-crossing gate. Magnesium 31-33 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 58-64 21207015-5 2011 Gene expression of TRPM7 increased with osteoblastic differentiation, suggesting the importance of intracellular Ca/Mg homeostasis to cell differentiation. Magnesium 116-118 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 19-24 21207015-6 2011 Alteration of intracellular Ca/Mg homeostasis by culture conditions with low extracellular Ca or Mg significantly reduced the osteoblastic differentiation markers alkaline phosphatase activity and osteocalcin gene expression. Magnesium 31-33 bone gamma-carboxyglutamate protein 2 Mus musculus 197-208 21207015-6 2011 Alteration of intracellular Ca/Mg homeostasis by culture conditions with low extracellular Ca or Mg significantly reduced the osteoblastic differentiation markers alkaline phosphatase activity and osteocalcin gene expression. Magnesium 97-99 bone gamma-carboxyglutamate protein 2 Mus musculus 197-208 21207015-10 2011 Gene expression of osteoblastic transcription factor Runx2 was reduced by conditions of culture under low extracellular Ca or Mg levels, as well as by TRPM7 silencing. Magnesium 126-128 runt related transcription factor 2 Mus musculus 53-58 21207015-11 2011 Our results indicate that intracellular Ca and Mg homeostasis ensured by TRPM7 expression is important for the osteoblastic differentiation of MC3T3 cells. Magnesium 47-49 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 73-78 21205110-0 2011 Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial. Magnesium 5-14 insulin Homo sapiens 39-46 21205110-1 2011 The incidence of insulin resistance and metabolic syndrome correlates with the availability of magnesium (Mg). Magnesium 95-104 insulin Homo sapiens 17-24 21205110-2 2011 We studied the effect of oral Mg supplementation on insulin sensitivity and other characteristics of the metabolic syndrome in normomagnesemic, overweight, insulin resistant, non-diabetic subjects. Magnesium 30-32 insulin Homo sapiens 52-59 21205110-5 2011 Mg supplementation resulted in a significant improvement of fasting plasma glucose and some insulin sensitivity indices (ISIs) compared to placebo. Magnesium 0-2 insulin Homo sapiens 92-99 21205110-7 2011 The results provide significant evidence that oral Mg supplementation improves insulin sensitivity even in normomagnesemic, overweight, non-diabetic subjects emphasizing the need for an early optimization of Mg status to prevent insulin resistance and subsequently type 2 diabetes. Magnesium 51-53 insulin Homo sapiens 79-86 21205110-7 2011 The results provide significant evidence that oral Mg supplementation improves insulin sensitivity even in normomagnesemic, overweight, non-diabetic subjects emphasizing the need for an early optimization of Mg status to prevent insulin resistance and subsequently type 2 diabetes. Magnesium 51-53 insulin Homo sapiens 229-236 21258847-1 2011 In the present study, we fabricated magnesium doped apatite cement (md-AC) with rapid self-setting characteristic by adding the mixed powders of magnesium oxide and calcium dihydrogen phosphate (MO-CDP) into hydroxyapatite cement (HAC). Magnesium 36-45 cut like homeobox 1 Homo sapiens 198-201 21239611-2 2011 Two types of Smad phosphatases--small C-terminal domain phosphatase 1 (SCP1) and protein phosphatase magnesium-dependent 1A--have been shown to inhibit BMP activity. Magnesium 101-110 bone morphogenetic protein 1 Homo sapiens 152-155 21077987-6 2011 Serum magnesium levels in group A were significantly lower than those in group B or C (A, 1.78 +- 0.16 mg/dL; B, 2.00 +- 0.14 mg/dL; C, 2.03 +- 0.10 mg/dL; A vs B, C, P < 0.01), and a significant correlation between these and the duration of CsA treatment was found (r = -0.68, P < 0.001). Magnesium 6-15 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 245-248 21421810-7 2011 This perturbation of sphingolipid biosynthesis in the Arabidopsis tsc10a mutant leads an altered leaf ionome, including increases in Na, K, and Rb and decreases in Mg, Ca, Fe, and Mo. Magnesium 164-166 NAD(P)-binding Rossmann-fold superfamily protein Arabidopsis thaliana 66-72 21199822-7 2011 On the other hand, the LiF:Mg,Cu,P material presents a stable behaviour within +- 5 %. Magnesium 27-29 LIF interleukin 6 family cytokine Homo sapiens 23-26 21103538-7 2011 The frequencies of the C=C vibrational modes are consistent with a six-coordinated state of the POR-bound Pchlide, suggesting that there are two coordination interactions between the central Mg atom of the chromophore and protein residues, and/or a water molecule. Magnesium 191-193 cytochrome p450 oxidoreductase Homo sapiens 96-99 21306649-13 2011 CONCLUSION: Our results indicate that for women PTH is a plausible mediator in the association between MS and a range of explanatory variables, including vit D, magnesium and phosphate. Magnesium 161-170 parathyroid hormone Homo sapiens 48-51 21237158-1 2011 The eukaryotic sulfiredoxin (Srx) catalyzes the reduction of overoxidized typical 2-Cys peroxiredoxins PrxSO(2) via ATP/Mg(2+)-dependent phosphorylation of the sulfinic acid group, followed by formation of a PrxSO-SSrx thiolsulfinate intermediate. Magnesium 120-122 sulfiredoxin 1 Homo sapiens 15-27 21237158-1 2011 The eukaryotic sulfiredoxin (Srx) catalyzes the reduction of overoxidized typical 2-Cys peroxiredoxins PrxSO(2) via ATP/Mg(2+)-dependent phosphorylation of the sulfinic acid group, followed by formation of a PrxSO-SSrx thiolsulfinate intermediate. Magnesium 120-122 sulfiredoxin 1 Homo sapiens 29-32 21159786-8 2011 RESULTS: We observed that magnesium treatment significantly decreased fasting C-peptide concentrations (change: -0.4 ng/mL after magnesium treatment compared with +0.05 ng/mL after placebo treatment; P = 0.004) and appeared to decrease fasting insulin concentrations (change: -2.2 muU/mL after magnesium treatment compared with 0.0 muU/mL after placebo treatment; P = 0.25). Magnesium 26-35 insulin Homo sapiens 244-251 21112948-2 2011 We tested the hypothesis that certain sphingolipids and neutral sphingomyelinase (N-SMase) can regulate intracellular free magnesium ions ([Mg2+]i) in vascular smooth muscle (VSM) cells. Magnesium 123-132 sphingomyelin phosphodiesterase 2 Rattus norvegicus 82-89 20691598-9 2011 Ca(2+)/Mg(2+) binding to the lanthanide complexes slows down the exchange of the amide protons on YbL(1) which is responsible for the diminished CEST effect. Magnesium 7-9 DNA polymerase epsilon 3, accessory subunit Homo sapiens 98-104 20803213-0 2011 Magnesium treatment for patients with refractory status epilepticus due to POLG1-mutations. Magnesium 0-9 DNA polymerase gamma, catalytic subunit Homo sapiens 75-80 21112970-4 2011 Inhibition of L-PGDS activity in MG-63 cells triggers redistribution of Arr3 and L-PGDS to the cytoplasm. Magnesium 33-35 prostaglandin D2 synthase Homo sapiens 14-20 21112970-4 2011 Inhibition of L-PGDS activity in MG-63 cells triggers redistribution of Arr3 and L-PGDS to the cytoplasm. Magnesium 33-35 arrestin 3 Homo sapiens 72-76 21112970-4 2011 Inhibition of L-PGDS activity in MG-63 cells triggers redistribution of Arr3 and L-PGDS to the cytoplasm. Magnesium 33-35 prostaglandin D2 synthase Homo sapiens 81-87 21272366-13 2011 Surprisingly, MG-132 but not IFN-gamma could also increase DR5-mediated apoptosis in SW948-TR. Magnesium 14-16 TNF receptor superfamily member 10b Homo sapiens 59-62 20940292-8 2011 Mature KLK8 activity was enhanced by calcium and magnesium ions and attenuated by zinc ions and by autocleavage after Arg(164). Magnesium 49-58 kallikrein related peptidase 8 Homo sapiens 7-11 21130072-2 2011 Recently heterozygous mutations in the HNF1B gene have been identified in patients with hypomagnesemia due to renal Mg(2+) wasting. Magnesium 116-118 HNF1 homeobox B Homo sapiens 39-44 21290295-2 2011 TRPM7 current is typically small at physiological magnesium concentrations, but large outwardly rectifying currents develop in low-magnesium extracellular solution when cells are dialyzed with magnesium free solutions during whole-cell patch clamp recordings. Magnesium 50-59 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 0-5 21290295-3 2011 In addition to regulation by magnesium, TRPM7 current is potentiated by low extracellular pH and inhibited by depletion of phosphatidylinositol 4,5-bisphosphate (PIP(2)) during phospholipase C mediated signaling events. Magnesium 29-38 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 40-45 21290295-4 2011 A diverse body of literature has implicated TRPM7 in fundamental cellular processes including death, survival, proliferation, cell cycle progression, magnesium homeostasis and responses to shear stress and oxidative stress. Magnesium 150-159 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 44-49 21047614-6 2011 After controlling for race, body mass index, admission hematocrit, induction status, magnesium therapy, and chorioamnionitis using logistic regression, oxytocin area under the curve continued to predict severe PPH. Magnesium 85-94 oxytocin/neurophysin I prepropeptide Homo sapiens 152-160 21791920-12 2011 CONCLUSION: This study supports the fundamental role of claudin 19 for magnesium homeostasis, normal tubular structures in the kidney, and undisturbed organization and development of the retina. Magnesium 71-80 claudin 19 Homo sapiens 56-66 29861700-0 2011 Minerals (Zn, Fe, Ca and Mg) and Antinutrient (Phytic Acid) Constituents in Common Bean. Magnesium 25-27 brain expressed associated with NEDD4 1 Homo sapiens 83-87 22471458-8 2011 RESULTS: KISS1 mRNA expression was moderate in U-2 OS, weak in Saos-2 and lost in MG-63. Magnesium 82-84 KiSS-1 metastasis suppressor Homo sapiens 9-14 20880582-9 2011 Furthermore, BMP-2 immobilized Ti promoted significantly higher ALP activity and calcium deposition by MG-63 cells than pristine Ti. Magnesium 103-105 bone morphogenetic protein 2 Homo sapiens 13-18 20932259-4 2011 In addition, mutations in the TRPM6 gene constitute the underlying genetic defect in hypomagnesemia with secondary hypocalcemia, a rare autosomal-recessive disease characterized by low serum magnesium accompanied by hypocalcemia. Magnesium 191-200 transient receptor potential cation channel, subfamily M, member 6 Mus musculus 30-35 21413179-8 2011 Our results show that this Hg20 detection method has excellent selectivity over other divalent metal ions (e.g. Pb(2+), Cu(2+), Mn(2+), Co(2+), Zn(2+), Cd(2+), Mg(2+), Ca(2+), and Ba(2+)). Magnesium 160-162 gamma-aminobutyric acid type B receptor subunit 2 Homo sapiens 27-31 21848011-1 2011 Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is caused by a mutation in the gene CLDN16, which encodes paracellin 1 (claudin-16), atight junction protein mediating paracellular transport which is expressed in the thick ascending loop of Henle and in the distal convoluted tubule, where reabsorption of magnesium occurs. Magnesium 330-339 claudin 16 Homo sapiens 109-115 21848011-1 2011 Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is caused by a mutation in the gene CLDN16, which encodes paracellin 1 (claudin-16), atight junction protein mediating paracellular transport which is expressed in the thick ascending loop of Henle and in the distal convoluted tubule, where reabsorption of magnesium occurs. Magnesium 330-339 claudin 16 Homo sapiens 131-143 21848011-1 2011 Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is caused by a mutation in the gene CLDN16, which encodes paracellin 1 (claudin-16), atight junction protein mediating paracellular transport which is expressed in the thick ascending loop of Henle and in the distal convoluted tubule, where reabsorption of magnesium occurs. Magnesium 330-339 claudin 16 Homo sapiens 145-155 21209254-6 2011 The Sweet Pee mutants had improved glucose tolerance, higher urinary excretion of calcium and magnesium, and growth retardation. Magnesium 94-103 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 10-13 21336731-1 2011 To construct a lentiviral shRNA vector targeting human protein phosphatase 1D magnesium-dependent (PPM1D) gene and detect its effectiveness of gene silencing in human gliomas, specific siRNA targets with short hairpin frame were designed and synthesized. Magnesium 78-87 protein phosphatase, Mg2+/Mn2+ dependent 1D Homo sapiens 55-77 21336731-1 2011 To construct a lentiviral shRNA vector targeting human protein phosphatase 1D magnesium-dependent (PPM1D) gene and detect its effectiveness of gene silencing in human gliomas, specific siRNA targets with short hairpin frame were designed and synthesized. Magnesium 78-87 protein phosphatase, Mg2+/Mn2+ dependent 1D Homo sapiens 99-104 21456209-5 2011 TPR results showed that addition of Mg facilitated the reduction of Fe2O3 and decrease in reduction temperature. Magnesium 36-38 translocated promoter region, nuclear basket protein Homo sapiens 0-3 21080035-3 2011 Human prothrombin was cleaved with cathepsin G in the absence of calcium and magnesium ions. Magnesium 77-86 coagulation factor II, thrombin Homo sapiens 6-17 20955720-7 2011 Similarly in the presence of amantadine or memantine the potency of Mg(2+) in blocking GluN1/GluN2A NMDARs was reduced. Magnesium 68-70 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 87-92 20955720-7 2011 Similarly in the presence of amantadine or memantine the potency of Mg(2+) in blocking GluN1/GluN2A NMDARs was reduced. Magnesium 68-70 glutamate ionotropic receptor NMDA type subunit 2A Homo sapiens 93-99 21168205-10 2011 RESULTS: Exposure to magnesium (0.7-7g/day) slightly decreased PP13 release from controls, and slightly increased it in preeclampsia and first trimester termination. Magnesium 21-30 galectin 13 Homo sapiens 63-67 21280127-8 2011 The first type of metal, which includes magnesium, calcium and manganese, invoked a slight stabilization of the active conformation of PAI-1. Magnesium 40-49 serpin family E member 1 Homo sapiens 135-140 22145455-0 2011 The relationship between serum magnesium levels with childhood obesity and insulin resistance: a review of the literature. Magnesium 31-40 insulin Homo sapiens 75-82 22145455-1 2011 BACKGROUND: Magnesium, the second most abundant intracellular cation, plays a major role in regulating insulin effect and insulin mediated glucose uptake. Magnesium 12-21 insulin Homo sapiens 103-110 22145455-1 2011 BACKGROUND: Magnesium, the second most abundant intracellular cation, plays a major role in regulating insulin effect and insulin mediated glucose uptake. Magnesium 12-21 insulin Homo sapiens 122-129 22145455-2 2011 It has been shown that serum magnesium levels were negatively correlated with HOMA-IR (homeostasis model of insulin resistance) index. Magnesium 29-38 insulin Homo sapiens 108-115 22145455-3 2011 AIM: To investigate the relationship between serum magnesium levels with obesity and insulin resistance in childhood. Magnesium 51-60 insulin Homo sapiens 85-92 22145455-9 2011 CONCLUSIONS: Low serum magnesium levels may contribute to the development of insulin resistance in obese children. Magnesium 23-32 insulin Homo sapiens 77-84 20729278-8 2011 In vitro recombinant TSSK2 activity assays showed maximum enzymatic activity at 5 mM Mg(2+) and a Km for ATP of ~10 microM. Magnesium 85-87 testis-specific serine kinase 2 Mus musculus 21-26 21490788-5 2011 Taken together, intrauterine magnesium deficiency in the fetus may lead to or at least program insulin resistance after birth. Magnesium 29-38 insulin Homo sapiens 95-102 21738593-0 2011 Regulation of Alr1 Mg transporter activity by intracellular magnesium. Magnesium 60-69 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 14-18 21335993-4 2011 Milk is an important source of minerals supporting growth (type II nutrients), such as potassium, magnesium, phosphorus and zinc, and the high lactose content also seems to support growth due to a prebiotic effect and improved absorption of minerals. Magnesium 98-107 Weaning weight-maternal milk Bos taurus 0-4 22163032-5 2011 When Ca(2+) mobilization is induced by BzATP, a P2X(7) agonist, it is attenuated in the presence of extracellular Mg(2+) or Zn(2+), negligible in the absence of extracellular Ca(2+), and inhibited by the competitive P2X7 receptor inhibitor, A438079. Magnesium 114-116 purinergic receptor P2X 7 Homo sapiens 48-54 22039534-7 2011 However, with luminal Ba(2+)or Mg(2+), RyR2 were less sensitive to cytosolic Ca(2+) and caffeine-mediated activation, openings were shorter and voltage-dependence was more marked (compared to RyR2 with luminal Ca(2+)or Sr(2+)). Magnesium 31-33 ryanodine receptor 2 Sus scrofa 39-43 22039534-7 2011 However, with luminal Ba(2+)or Mg(2+), RyR2 were less sensitive to cytosolic Ca(2+) and caffeine-mediated activation, openings were shorter and voltage-dependence was more marked (compared to RyR2 with luminal Ca(2+)or Sr(2+)). Magnesium 31-33 ryanodine receptor 2 Sus scrofa 192-196 21738593-2 2011 In yeast, Mg uptake is primarily mediated by the Alr1 transporter, which also allows low affinity uptake of other divalent cations such as Ni(2+), Mn(2+), Zn(2+) and Co(2+). Magnesium 10-12 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 49-53 21738593-3 2011 Using Ni(2+) uptake to assay Alr1 activity, we observed approximately nine-fold more activity under Mg-deficient conditions. Magnesium 100-102 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 29-33 21738593-4 2011 The mnr2 mutation, which is thought to block release of vacuolar Mg stores, was associated with increased Alr1 activity, suggesting Alr1 was regulated by intracellular Mg supply. Magnesium 65-67 putative Mg(2+) transporter MNR2 Saccharomyces cerevisiae S288C 4-8 21738593-4 2011 The mnr2 mutation, which is thought to block release of vacuolar Mg stores, was associated with increased Alr1 activity, suggesting Alr1 was regulated by intracellular Mg supply. Magnesium 168-170 putative Mg(2+) transporter MNR2 Saccharomyces cerevisiae S288C 4-8 21738593-4 2011 The mnr2 mutation, which is thought to block release of vacuolar Mg stores, was associated with increased Alr1 activity, suggesting Alr1 was regulated by intracellular Mg supply. Magnesium 168-170 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 132-136 21738593-5 2011 Consistent with a previous report of the regulation of Alr1 expression by Mg supply, Mg deficiency and the mnr2 mutation both increased the accumulation of a carboxy-terminal epitope-tagged version of the Alr1 protein (Alr1-HA). Magnesium 74-76 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 55-59 21738593-5 2011 Consistent with a previous report of the regulation of Alr1 expression by Mg supply, Mg deficiency and the mnr2 mutation both increased the accumulation of a carboxy-terminal epitope-tagged version of the Alr1 protein (Alr1-HA). Magnesium 74-76 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 205-209 21738593-5 2011 Consistent with a previous report of the regulation of Alr1 expression by Mg supply, Mg deficiency and the mnr2 mutation both increased the accumulation of a carboxy-terminal epitope-tagged version of the Alr1 protein (Alr1-HA). Magnesium 74-76 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 205-209 22180838-0 2011 Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity. Magnesium 56-65 transient receptor potential cation channel subfamily M member 6 Homo sapiens 77-82 21179559-1 2010 In a previous study we proposed that the depolarized state of the wake-promoting hypocretin/orexin (hcrt/orx) neurons was independent of synaptic inputs as it persisted in tetrodotoxin and low calcium/high magnesium solutions. Magnesium 206-215 hypocretin neuropeptide precursor Rattus norvegicus 81-98 21179559-1 2010 In a previous study we proposed that the depolarized state of the wake-promoting hypocretin/orexin (hcrt/orx) neurons was independent of synaptic inputs as it persisted in tetrodotoxin and low calcium/high magnesium solutions. Magnesium 206-215 hypocretin neuropeptide precursor Rattus norvegicus 100-104 20932883-6 2010 The Mg-sensitive part of (109)Cd uptake increased at acidic pH, a condition known to stimulate TRPM7 channel activity. Magnesium 4-6 transient receptor potential cation channel subfamily M member 7 Homo sapiens 95-100 20932883-7 2010 Stimulating TRPM7 channel activity by cellular Mg starvation enhanced (109)Cd uptake. Magnesium 47-49 transient receptor potential cation channel subfamily M member 7 Homo sapiens 12-17 20932883-8 2010 Silencing TRPM7 channel expression abolished the Mg-sensitive and the Mg starvation-induced uptake indicating that TRPM7 is involved in Cd transport in osteoblasts. Magnesium 49-51 transient receptor potential cation channel subfamily M member 7 Homo sapiens 10-15 20932883-8 2010 Silencing TRPM7 channel expression abolished the Mg-sensitive and the Mg starvation-induced uptake indicating that TRPM7 is involved in Cd transport in osteoblasts. Magnesium 49-51 transient receptor potential cation channel subfamily M member 7 Homo sapiens 115-120 20932883-8 2010 Silencing TRPM7 channel expression abolished the Mg-sensitive and the Mg starvation-induced uptake indicating that TRPM7 is involved in Cd transport in osteoblasts. Magnesium 70-72 transient receptor potential cation channel subfamily M member 7 Homo sapiens 10-15 20932883-8 2010 Silencing TRPM7 channel expression abolished the Mg-sensitive and the Mg starvation-induced uptake indicating that TRPM7 is involved in Cd transport in osteoblasts. Magnesium 70-72 transient receptor potential cation channel subfamily M member 7 Homo sapiens 115-120 20935146-0 2010 Short-term magnesium deficiency upregulates sphingomyelin synthase and p53 in cardiovascular tissues and cells: relevance to the de novo synthesis of ceramide. Magnesium 11-20 spermine synthase Rattus norvegicus 44-66 20935146-0 2010 Short-term magnesium deficiency upregulates sphingomyelin synthase and p53 in cardiovascular tissues and cells: relevance to the de novo synthesis of ceramide. Magnesium 11-20 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 71-74 20935146-2 2010 The data indicated that short-term magnesium deficiency (10% normal dietary intake) resulted in the upregulation of SMS and p53 in both ventricular and aortic smooth muscles; even very low levels of water-borne Mg(2+) (e.g., 15 mg l(-1) day(-1)) either prevented or ameliorated the upregulation in SMS and p53. Magnesium 35-44 spermine synthase Rattus norvegicus 116-119 20935146-2 2010 The data indicated that short-term magnesium deficiency (10% normal dietary intake) resulted in the upregulation of SMS and p53 in both ventricular and aortic smooth muscles; even very low levels of water-borne Mg(2+) (e.g., 15 mg l(-1) day(-1)) either prevented or ameliorated the upregulation in SMS and p53. Magnesium 35-44 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 124-127 20935146-2 2010 The data indicated that short-term magnesium deficiency (10% normal dietary intake) resulted in the upregulation of SMS and p53 in both ventricular and aortic smooth muscles; even very low levels of water-borne Mg(2+) (e.g., 15 mg l(-1) day(-1)) either prevented or ameliorated the upregulation in SMS and p53. Magnesium 35-44 spermine synthase Rattus norvegicus 298-301 20935146-2 2010 The data indicated that short-term magnesium deficiency (10% normal dietary intake) resulted in the upregulation of SMS and p53 in both ventricular and aortic smooth muscles; even very low levels of water-borne Mg(2+) (e.g., 15 mg l(-1) day(-1)) either prevented or ameliorated the upregulation in SMS and p53. Magnesium 35-44 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 306-309 20859819-1 2010 The curative waters of HCO3-SO4-Mg-Na+H2S chemical type and 0.6-0.8 g/dm3 total dissolved solids are exploited in Horyniec Spa located at the northern boundary of the Carpathian Foredeep, near the Polish-Ukrainian border. Magnesium 32-34 surfactant protein A2 Homo sapiens 123-126 21240387-5 2010 Stretching of cardiomyocytes isolated from wild type mice and from NOS1(-/-)- and NOS2(-/-)- knockout mice led to the appearance in MG-currents typical for the specified magnitude of stretching, while stretching of cardiomyocytes from NOS3(-/-)- knockout mice did not produce in MG-current. Magnesium 132-134 nitric oxide synthase 1, neuronal Mus musculus 67-71 21240387-5 2010 Stretching of cardiomyocytes isolated from wild type mice and from NOS1(-/-)- and NOS2(-/-)- knockout mice led to the appearance in MG-currents typical for the specified magnitude of stretching, while stretching of cardiomyocytes from NOS3(-/-)- knockout mice did not produce in MG-current. Magnesium 132-134 nitric oxide synthase 2, inducible Mus musculus 82-86 21240387-5 2010 Stretching of cardiomyocytes isolated from wild type mice and from NOS1(-/-)- and NOS2(-/-)- knockout mice led to the appearance in MG-currents typical for the specified magnitude of stretching, while stretching of cardiomyocytes from NOS3(-/-)- knockout mice did not produce in MG-current. Magnesium 279-281 nitric oxide synthase 1, neuronal Mus musculus 67-71 21240387-5 2010 Stretching of cardiomyocytes isolated from wild type mice and from NOS1(-/-)- and NOS2(-/-)- knockout mice led to the appearance in MG-currents typical for the specified magnitude of stretching, while stretching of cardiomyocytes from NOS3(-/-)- knockout mice did not produce in MG-current. Magnesium 279-281 nitric oxide synthase 2, inducible Mus musculus 82-86 20807870-0 2010 Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Magnesium 0-9 insulin Homo sapiens 55-62 20807870-1 2010 OBJECTIVE: To investigate the long-term associations of magnesium intake with incidence of diabetes, systemic inflammation, and insulin resistance among young American adults. Magnesium 56-65 insulin Homo sapiens 128-135 20807870-7 2010 Consistently, magnesium intake was significantly inversely associated with hs-CRP, IL-6, fibrinogen, and HOMA-IR, and serum magnesium levels were inversely correlated with hs-CRP and HOMA-IR. Magnesium 14-23 interleukin 6 Homo sapiens 83-87 20807870-9 2010 This inverse association may be explained, at least in part, by the inverse correlations of magnesium intake with systemic inflammation and insulin resistance. Magnesium 92-101 insulin Homo sapiens 140-147 20881241-1 2010 The transient receptor potential melastatin 7 (trpm7) channel kinase is a primary regulator of magnesium homeostasis in vitro. Magnesium 95-104 transient receptor potential cation channel, subfamily M, member 7 Danio rerio 4-45 20881241-1 2010 The transient receptor potential melastatin 7 (trpm7) channel kinase is a primary regulator of magnesium homeostasis in vitro. Magnesium 95-104 transient receptor potential cation channel, subfamily M, member 7 Danio rerio 47-52 20881241-3 2010 Using zebrafish trpm7 mutants, we show that early larvae exhibit reduced levels of both total magnesium and total calcium. Magnesium 94-103 transient receptor potential cation channel, subfamily M, member 7 Danio rerio 16-21 20881241-5 2010 Using transgenic overexpression and morpholino oligonucleotide knockdown, we demonstrate that stc1 modulates both calcium and magnesium levels in trpm7 mutants and in the wild type and that levels of these cations are restored to normal in trpm7 mutants when stc1 activity is blocked. Magnesium 126-135 stanniocalcin 1 Danio rerio 94-98 20881241-5 2010 Using transgenic overexpression and morpholino oligonucleotide knockdown, we demonstrate that stc1 modulates both calcium and magnesium levels in trpm7 mutants and in the wild type and that levels of these cations are restored to normal in trpm7 mutants when stc1 activity is blocked. Magnesium 126-135 transient receptor potential cation channel, subfamily M, member 7 Danio rerio 146-151 21199787-14 2010 Magnesium supplementation vs placebo decreased plasma CRP in participants with baseline values > 3.0 mg/L. Magnesium 0-9 C-reactive protein Homo sapiens 54-57 21233058-5 2010 Ca:Mg rose from largely below 3.0 in 1994-5 to generally above or approaching 3.0 after 2000, coinciding with a sharp 2% rise in type 2 diabetes incidence and prevalence in the USA population and a 1994-2005 rise in colorectal cancer incidence among young white, non-Hispanic adult men and women in the USA. Magnesium 3-5 basic helix-loop-helix family member e40 Homo sapiens 112-119 21045827-6 2010 Cells derived from heterozygous TRPM7(Deltakinase) mice demonstrated reduced TRPM7 currents that had increased sensitivity to the inhibition by Mg(2+). Magnesium 144-146 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 32-37 20831861-0 2010 GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity. Magnesium 71-80 gap junction protein, delta 2 Mus musculus 26-36 20923173-12 2010 In all Mg2+ binding motifs, a key hydrogen bond was identified between a magnesium-bound water and Cys1p, bridging the two metallic binding sites and, thereby, reducing the equilibrium distance between the reacting atoms of FPP Cys1p. Magnesium 73-82 cystin 1 Homo sapiens 99-104 20923173-12 2010 In all Mg2+ binding motifs, a key hydrogen bond was identified between a magnesium-bound water and Cys1p, bridging the two metallic binding sites and, thereby, reducing the equilibrium distance between the reacting atoms of FPP Cys1p. Magnesium 73-82 cystin 1 Homo sapiens 228-233 21045827-6 2010 Cells derived from heterozygous TRPM7(Deltakinase) mice demonstrated reduced TRPM7 currents that had increased sensitivity to the inhibition by Mg(2+). Magnesium 144-146 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 77-82 20600865-5 2010 In the present study, we show that exposure of endothelial cells to low magnesium increases the secretion of RANTES, interleukin 8 and platelet derived growth factor BB, all important players in atherogenesis. Magnesium 72-81 C-C motif chemokine ligand 5 Homo sapiens 109-115 20600865-5 2010 In the present study, we show that exposure of endothelial cells to low magnesium increases the secretion of RANTES, interleukin 8 and platelet derived growth factor BB, all important players in atherogenesis. Magnesium 72-81 C-X-C motif chemokine ligand 8 Homo sapiens 117-130 21284342-3 2010 Transient receptor potential melastatin 6 (TRPM6) is a newly identified channel that is involved in active epithelial magnesium transport, and downregulation of TRPM6 in the kidney was related to reduced Mg2+ reabsorption in mouse model. Magnesium 118-127 transient receptor potential cation channel, subfamily M, member 6 Mus musculus 0-41 20497442-2 2010 MATERIAL AND METHODS: Mg-incorporated Ti oxide surfaces were produced by hydrothermal treatment using Mg-containing solution on two different microstructured surfaces--abraded minimally rough (Ma) or grit-blasted moderately rough (RBM) samples. Magnesium 22-24 RNA binding motif protein, Y chromosome Mus musculus 231-234 20497442-11 2010 Mg incorporation further increased the mRNA expressions of key osteoblast genes and integrins (alpha1, alpha2, alpha5, and beta1) in cells grown on both the smooth and the micro-rough surfaces. Magnesium 0-2 hemoglobin, beta adult major chain Mus musculus 103-128 21284342-3 2010 Transient receptor potential melastatin 6 (TRPM6) is a newly identified channel that is involved in active epithelial magnesium transport, and downregulation of TRPM6 in the kidney was related to reduced Mg2+ reabsorption in mouse model. Magnesium 118-127 transient receptor potential cation channel, subfamily M, member 6 Mus musculus 43-48 21284342-4 2010 The aim of the study was to investigate whether plasma and erythrocyte magnesium levels were correlated with renal expression of TRPM6 mRNA in C57BL/6 asthmatic mice. Magnesium 71-80 transient receptor potential cation channel, subfamily M, member 6 Mus musculus 129-134 20694825-1 2010 It has already been shown that the mutant Leu94Gly of horse cytochrome c exists in a molten globule (MG) state. Magnesium 101-103 cytochrome c, somatic Equus caballus 60-72 20806408-9 2010 Additionally, the L10P, L166P, and P158DEL DJ-1 variants exhibited altered profiles on size-exclusion chromatography and demonstrated reduced solubilities in comparison with WT protein, and the latter aberration could be exacerbated in the presence of MG-132. Magnesium 252-254 immunoglobulin kappa variable 3-7 (non-functional) Homo sapiens 18-22 20806408-9 2010 Additionally, the L10P, L166P, and P158DEL DJ-1 variants exhibited altered profiles on size-exclusion chromatography and demonstrated reduced solubilities in comparison with WT protein, and the latter aberration could be exacerbated in the presence of MG-132. Magnesium 252-254 Parkinsonism associated deglycase Homo sapiens 43-47 20862437-3 2010 The molar ratio of Mg2(+):Ca2(+):CO32-and the concentrations of the reactants (CaCl2, Na2CO3, and MgCl2) play important roles in the Mg:Ca molar ratio of the obtained Mg-ACC nanoparticles. Magnesium 98-100 mucin 7, secreted Homo sapiens 19-22 20811796-0 2010 Calcium and Magnesium Supplementation Improves Serum OPG/RANKL in Calcium-Deficient Ovariectomized Rats. Magnesium 12-21 TNF receptor superfamily member 11B Rattus norvegicus 53-56 21169130-0 2010 Plasma matrix metalloproteinase 9 correlates with disorders of brain magnesium homeostasis in patients undergoing coronary artery bypass surgery. Magnesium 69-78 matrix metallopeptidase 9 Homo sapiens 7-33 20811796-0 2010 Calcium and Magnesium Supplementation Improves Serum OPG/RANKL in Calcium-Deficient Ovariectomized Rats. Magnesium 12-21 TNF superfamily member 11 Rattus norvegicus 57-62 20811796-1 2010 Magnesium (Mg) deficiency has been reported to result in increases in bone resorption through changes in the cytokine system, such as decreases in serum osteoprotegerin (OPG) concentrations and increases in receptor activator of NF-kappaB ligand (RANKL) concentrations. Magnesium 0-9 TNF receptor superfamily member 11B Rattus norvegicus 153-168 20811796-1 2010 Magnesium (Mg) deficiency has been reported to result in increases in bone resorption through changes in the cytokine system, such as decreases in serum osteoprotegerin (OPG) concentrations and increases in receptor activator of NF-kappaB ligand (RANKL) concentrations. Magnesium 0-9 TNF receptor superfamily member 11B Rattus norvegicus 170-173 20811796-1 2010 Magnesium (Mg) deficiency has been reported to result in increases in bone resorption through changes in the cytokine system, such as decreases in serum osteoprotegerin (OPG) concentrations and increases in receptor activator of NF-kappaB ligand (RANKL) concentrations. Magnesium 0-9 TNF superfamily member 11 Rattus norvegicus 207-245 20811796-1 2010 Magnesium (Mg) deficiency has been reported to result in increases in bone resorption through changes in the cytokine system, such as decreases in serum osteoprotegerin (OPG) concentrations and increases in receptor activator of NF-kappaB ligand (RANKL) concentrations. Magnesium 0-9 TNF superfamily member 11 Rattus norvegicus 247-252 20811796-1 2010 Magnesium (Mg) deficiency has been reported to result in increases in bone resorption through changes in the cytokine system, such as decreases in serum osteoprotegerin (OPG) concentrations and increases in receptor activator of NF-kappaB ligand (RANKL) concentrations. Magnesium 11-13 TNF receptor superfamily member 11B Rattus norvegicus 153-168 20811796-1 2010 Magnesium (Mg) deficiency has been reported to result in increases in bone resorption through changes in the cytokine system, such as decreases in serum osteoprotegerin (OPG) concentrations and increases in receptor activator of NF-kappaB ligand (RANKL) concentrations. Magnesium 11-13 TNF receptor superfamily member 11B Rattus norvegicus 170-173 20811796-1 2010 Magnesium (Mg) deficiency has been reported to result in increases in bone resorption through changes in the cytokine system, such as decreases in serum osteoprotegerin (OPG) concentrations and increases in receptor activator of NF-kappaB ligand (RANKL) concentrations. Magnesium 11-13 TNF superfamily member 11 Rattus norvegicus 207-245 20811796-1 2010 Magnesium (Mg) deficiency has been reported to result in increases in bone resorption through changes in the cytokine system, such as decreases in serum osteoprotegerin (OPG) concentrations and increases in receptor activator of NF-kappaB ligand (RANKL) concentrations. Magnesium 11-13 TNF superfamily member 11 Rattus norvegicus 247-252 20811796-2 2010 However, there are few data about the effects of Mg supplementation on OPG and RANKL. Magnesium 49-51 TNF receptor superfamily member 11B Rattus norvegicus 71-74 20811796-2 2010 However, there are few data about the effects of Mg supplementation on OPG and RANKL. Magnesium 49-51 TNF superfamily member 11 Rattus norvegicus 79-84 20804539-7 2010 Interestingly, IL-6(-/-) mice had intact MG formation; however, SG organization was impaired. Magnesium 41-43 interleukin 6 Mus musculus 15-19 20660032-10 2010 Mean serum Ca and P significantly increased compared to baseline, whereas serum Mg decreased at 3 d. Magnesium 80-82 serpin family C member 1 Homo sapiens 93-99 20713064-0 2010 Magnesium-dependent interaction of PKR with adenovirus VAI. Magnesium 0-9 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 35-38 20713064-8 2010 Two PKR monomers bind in the absence of Mg(2+), but a single monomer binds in the presence of divalent ion. Magnesium 40-42 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 4-7 20633668-7 2010 RESULTS: Magnesium increased adhesion of human synovial MSCs to collagen, and this effect was inhibited by neutralizing antibodies for integrin alpha3 and beta1. Magnesium 9-18 integrin subunit alpha 3 Homo sapiens 135-150 24421973-10 2010 CONCLUSIONS: The magnesium-incorporated anodized surface showed significantly higher fibronectin adsorption and lower albumin adsorption than the blasted surface. Magnesium 17-26 fibronectin 1 Homo sapiens 85-96 20633668-7 2010 RESULTS: Magnesium increased adhesion of human synovial MSCs to collagen, and this effect was inhibited by neutralizing antibodies for integrin alpha3 and beta1. Magnesium 9-18 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 155-160 20633668-8 2010 Magnesium also promoted synthesis of cartilage matrix during in vitro chondrogenesis of synovial MSCs, which was diminished by neutralizing antibodies for integrin beta1 but not for integrin alpha3. Magnesium 0-9 integrin subunit beta 1 Homo sapiens 155-169 20970606-0 2010 Changes in magnesium and potassium homeostasis after conversion from a calcineurin inhibitor regimen to an mTOR inhibitor-based regimen. Magnesium 11-20 mechanistic target of rapamycin kinase Homo sapiens 107-111 20970606-3 2010 OBJECTIVE: To evaluate the potassium and magnesium changes due to converting patients from CNIs to mTOR inhibitors. Magnesium 41-50 mechanistic target of rapamycin kinase Homo sapiens 99-103 20678472-5 2010 It activated multicaspases, and increased the activities of caspase-8 and caspase-9 in both MG-63 and SaOS-2 cells. Magnesium 92-94 caspase 8 Homo sapiens 60-69 20122908-6 2010 Senescence marker protein (SMP30), another putative six-bladed beta-propeller, hydrolyzes DFP, sarin and soman in the presence of Mg(2+) or Mn(2+). Magnesium 130-132 regucalcin Homo sapiens 27-32 21134864-8 2010 The mucoadhesive properties of MGs were evaluated in aqueous solution by measuring the mucin adsorbed on MGs. Magnesium 31-34 LOC100508689 Homo sapiens 87-92 21134864-8 2010 The mucoadhesive properties of MGs were evaluated in aqueous solution by measuring the mucin adsorbed on MGs. Magnesium 105-108 LOC100508689 Homo sapiens 87-92 20581087-0 2010 Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome c. The present work tested the hypothesis that a short-term dietary deficiency of magnesium (Mg) (21 days) in rats would result in the upregulation of the two major subunits of serine palmitoyl-CoA-transferase, serine palmitoyl transferase (SPT 1) and SPT 2 (the rate-limiting enzymes responsible for the de novo biosynthesis of ceramides) in left ventricular, right ventricular, and atrial heart muscle and abdominal aortic smooth muscle, as well as induce a reduction in serum sphingomyelin concomitant with the release of mitochondrial cytochrome c (Cyto c) in these tissues. Magnesium 0-9 salivary protein 1 Rattus norvegicus 63-68 20581087-0 2010 Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome c. The present work tested the hypothesis that a short-term dietary deficiency of magnesium (Mg) (21 days) in rats would result in the upregulation of the two major subunits of serine palmitoyl-CoA-transferase, serine palmitoyl transferase (SPT 1) and SPT 2 (the rate-limiting enzymes responsible for the de novo biosynthesis of ceramides) in left ventricular, right ventricular, and atrial heart muscle and abdominal aortic smooth muscle, as well as induce a reduction in serum sphingomyelin concomitant with the release of mitochondrial cytochrome c (Cyto c) in these tissues. Magnesium 0-9 salivary protein 1 Rattus norvegicus 396-401 20635860-0 2010 Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein. Magnesium 11-20 furin, paired basic amino acid cleaving enzyme Homo sapiens 47-52 20635860-0 2010 Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein. Magnesium 11-20 endogenous retrovirus group K member 20 Homo sapiens 133-154 20635860-1 2010 Here we report a detailed analysis of magnesium (Mg2+) ion effects on furin hydrolysis of fluorescent resonance energy transfer decapeptide substrates derived from canonical R-X-K/R-R furin cleavage motifs within certain viral envelope glycoproteins and eukaryotic proproteins. Magnesium 38-47 furin, paired basic amino acid cleaving enzyme Homo sapiens 70-75 20635860-1 2010 Here we report a detailed analysis of magnesium (Mg2+) ion effects on furin hydrolysis of fluorescent resonance energy transfer decapeptide substrates derived from canonical R-X-K/R-R furin cleavage motifs within certain viral envelope glycoproteins and eukaryotic proproteins. Magnesium 38-47 furin, paired basic amino acid cleaving enzyme Homo sapiens 184-189 20978615-2 2010 A prototype compound was designed and docked into the catalytic domain of the AdSS enzyme bridging the region between the magnesium center of the protein to the nucleoside region. Magnesium 122-131 adenylosuccinate synthase 2 Homo sapiens 78-82 20601877-8 2010 SUMMARY: Basolateral K channels including big-conductance K channel and Kir4.1/5.1 play an important role in regulating Na and Mg transport in the ASDN. Magnesium 127-129 potassium inwardly-rectifying channel, subfamily J, member 10 Mus musculus 72-78 20616717-1 2010 PURPOSE OF REVIEW: Claudin-16 and claudin-19 play a major role in the regulation of magnesium reabsorption in the thick ascending limb (TAL). Magnesium 84-93 claudin 16 Mus musculus 19-29 20616717-1 2010 PURPOSE OF REVIEW: Claudin-16 and claudin-19 play a major role in the regulation of magnesium reabsorption in the thick ascending limb (TAL). Magnesium 84-93 claudin 19 Mus musculus 34-44 20616717-2 2010 This review describes recent findings of the physiological function of claudin-16 and claudin-19 underlying normal transport function for magnesium reabsorption in the TAL. Magnesium 138-147 claudin 16 Mus musculus 71-81 20616717-2 2010 This review describes recent findings of the physiological function of claudin-16 and claudin-19 underlying normal transport function for magnesium reabsorption in the TAL. Magnesium 138-147 claudin 19 Mus musculus 86-96 20616717-7 2010 Loss of either claudin-16 or claudin-19 in the mouse kidney abolishes the cation selectivity for the TAL paracellular pathway, leading to excessive renal wasting of magnesium. Magnesium 165-174 claudin 16 Mus musculus 15-25 20616717-7 2010 Loss of either claudin-16 or claudin-19 in the mouse kidney abolishes the cation selectivity for the TAL paracellular pathway, leading to excessive renal wasting of magnesium. Magnesium 165-174 claudin 19 Mus musculus 29-39 20616717-9 2010 In the mouse TAL, claudin-16 and claudin-19 cooperate to form cation-selective paracellular channels required for normal levels of magnesium reabsorption. Magnesium 131-140 claudin 16 Mus musculus 18-28 20616717-9 2010 In the mouse TAL, claudin-16 and claudin-19 cooperate to form cation-selective paracellular channels required for normal levels of magnesium reabsorption. Magnesium 131-140 claudin 19 Mus musculus 33-43 21787646-8 2010 The results also provide evidence that V-Mg interactions may be involved in the decrease of erythrocyte GR activity and Mg concentration in the plasma under concomitant treatment with both metals at the doses of 12.6mgV and 6mgMg/kg b.w./24h. Magnesium 41-43 glutathione-disulfide reductase Rattus norvegicus 104-106 20696983-0 2010 Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Magnesium 100-109 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 80-85 20696983-9 2010 Magnesium prevented calcification and decreased osteocalcin expression and BMP-2 activity and increased expression of calcification inhibitors, osteopontin and matrix Gla protein. Magnesium 0-9 bone gamma-carboxyglutamate protein 2 Mus musculus 48-59 20696983-9 2010 Magnesium prevented calcification and decreased osteocalcin expression and BMP-2 activity and increased expression of calcification inhibitors, osteopontin and matrix Gla protein. Magnesium 0-9 bone morphogenetic protein 2 Mus musculus 75-80 20696983-9 2010 Magnesium prevented calcification and decreased osteocalcin expression and BMP-2 activity and increased expression of calcification inhibitors, osteopontin and matrix Gla protein. Magnesium 0-9 secreted phosphoprotein 1 Mus musculus 144-155 20696983-9 2010 Magnesium prevented calcification and decreased osteocalcin expression and BMP-2 activity and increased expression of calcification inhibitors, osteopontin and matrix Gla protein. Magnesium 0-9 matrix Gla protein Mus musculus 160-178 20696983-10 2010 TRPM 7 activation was decreased by calcification medium, an effect reversed by magnesium. Magnesium 79-88 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 0-6 20696983-13 2010 Magnesium negatively regulates vascular calcification and osteogenic differentiation through increased/restored TRPM7 activity and increased expression of anticalcification proteins, including osteopontin, BMP-7, and matrix Gla protein. Magnesium 0-9 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 112-117 20696983-13 2010 Magnesium negatively regulates vascular calcification and osteogenic differentiation through increased/restored TRPM7 activity and increased expression of anticalcification proteins, including osteopontin, BMP-7, and matrix Gla protein. Magnesium 0-9 secreted phosphoprotein 1 Mus musculus 193-204 20696983-13 2010 Magnesium negatively regulates vascular calcification and osteogenic differentiation through increased/restored TRPM7 activity and increased expression of anticalcification proteins, including osteopontin, BMP-7, and matrix Gla protein. Magnesium 0-9 bone morphogenetic protein 7 Mus musculus 206-211 20696983-13 2010 Magnesium negatively regulates vascular calcification and osteogenic differentiation through increased/restored TRPM7 activity and increased expression of anticalcification proteins, including osteopontin, BMP-7, and matrix Gla protein. Magnesium 0-9 matrix Gla protein Mus musculus 217-235 20371155-10 2010 Mg level directly influences transient receptor potential melastatin 7 (TRPM7) related Ca influx, calcium-adenosine triphosphatase (Ca-ATP) levels, and cell proliferation, and thereby could lead to cancer. Magnesium 0-2 transient receptor potential cation channel subfamily M member 7 Homo sapiens 29-70 20371155-10 2010 Mg level directly influences transient receptor potential melastatin 7 (TRPM7) related Ca influx, calcium-adenosine triphosphatase (Ca-ATP) levels, and cell proliferation, and thereby could lead to cancer. Magnesium 0-2 transient receptor potential cation channel subfamily M member 7 Homo sapiens 72-77 20719712-0 2010 Downregulation of HD-PTP by high magnesium concentration: novel insights into magnesium-induced endothelial migration. Magnesium 33-42 protein tyrosine phosphatase non-receptor type 23 Homo sapiens 18-24 20719712-0 2010 Downregulation of HD-PTP by high magnesium concentration: novel insights into magnesium-induced endothelial migration. Magnesium 78-87 protein tyrosine phosphatase non-receptor type 23 Homo sapiens 18-24 20719712-3 2010 Interestingly, we show that magnesium induced-endothelial motility correlates with the downregulation of HD-PTP, a potential tyrosine phopshatase previously shown to be involved in modulating cell migration. Magnesium 28-37 protein tyrosine phosphatase non-receptor type 23 Homo sapiens 105-111 20719712-6 2010 Our results indicate that, in the presence of high magnesium concentrations, endothelial cells are stimulated to migrate through complex mechanisms involving also HD-PTP. Magnesium 51-60 protein tyrosine phosphatase non-receptor type 23 Homo sapiens 163-169 20810356-0 2010 Dietary magnesium supplementation suppresses bone resorption via inhibition of parathyroid hormone secretion in rats fed a high-phosphorus diet. Magnesium 8-17 parathyroid hormone Rattus norvegicus 79-98 20810356-6 2010 Dietary Mg supplementation had a significant influence on serum PTH levels in the HP and HPHMg groups. Magnesium 8-10 parathyroid hormone Rattus norvegicus 64-67 20810356-7 2010 These results suggest that dietary Mg supplementation suppresses the high bone resorption induced by a high-P diet via inhibition of PTH secretion. Magnesium 35-37 parathyroid hormone Rattus norvegicus 133-136 20401728-8 2010 Using FluoZin3 to image changes of the intracellular zinc concentration, we show that pancreatic beta-cells take up zinc through TRPM3 channels even when extracellular zinc concentrations are low and physiological levels of calcium and magnesium are present. Magnesium 236-245 transient receptor potential cation channel subfamily M member 3 Homo sapiens 129-134 20678472-5 2010 It activated multicaspases, and increased the activities of caspase-8 and caspase-9 in both MG-63 and SaOS-2 cells. Magnesium 92-94 caspase 9 Homo sapiens 74-83 20700443-5 2010 The association of common variants at six genomic regions (in or near MUC1, ATP2B1, DCDC5, TRPM6, SHROOM3, and MDS1) with serum magnesium levels was genome-wide significant when meta-analyzed with the replication dataset. Magnesium 128-137 mucin 1, cell surface associated Homo sapiens 70-74 20700443-5 2010 The association of common variants at six genomic regions (in or near MUC1, ATP2B1, DCDC5, TRPM6, SHROOM3, and MDS1) with serum magnesium levels was genome-wide significant when meta-analyzed with the replication dataset. Magnesium 128-137 ATPase plasma membrane Ca2+ transporting 1 Homo sapiens 76-82 20700443-5 2010 The association of common variants at six genomic regions (in or near MUC1, ATP2B1, DCDC5, TRPM6, SHROOM3, and MDS1) with serum magnesium levels was genome-wide significant when meta-analyzed with the replication dataset. Magnesium 128-137 doublecortin domain containing 5 Homo sapiens 84-89 20700443-5 2010 The association of common variants at six genomic regions (in or near MUC1, ATP2B1, DCDC5, TRPM6, SHROOM3, and MDS1) with serum magnesium levels was genome-wide significant when meta-analyzed with the replication dataset. Magnesium 128-137 transient receptor potential cation channel subfamily M member 6 Homo sapiens 91-96 20700443-5 2010 The association of common variants at six genomic regions (in or near MUC1, ATP2B1, DCDC5, TRPM6, SHROOM3, and MDS1) with serum magnesium levels was genome-wide significant when meta-analyzed with the replication dataset. Magnesium 128-137 shroom family member 3 Homo sapiens 98-105 20700443-5 2010 The association of common variants at six genomic regions (in or near MUC1, ATP2B1, DCDC5, TRPM6, SHROOM3, and MDS1) with serum magnesium levels was genome-wide significant when meta-analyzed with the replication dataset. Magnesium 128-137 MDS1 and EVI1 complex locus Homo sapiens 111-115 20700443-7 2010 Common variants in CNNM2, a magnesium transporter studied only in model systems to date, as well as in CNNM3 and CNNM4, were also associated with magnesium concentrations in this study. Magnesium 28-37 cyclin and CBS domain divalent metal cation transport mediator 2 Homo sapiens 19-24 20595681-0 2010 Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling. Magnesium 43-52 epidermal growth factor receptor Homo sapiens 15-19 20435075-5 2010 The metal ion magnesium (a co-factor for endonuclease) enhanced the Tau DNA nicking ability, while an endonuclease specific inhibitor, aurinetricarboxylic acid (ATA) inhibited the Tau DNA nicking ability. Magnesium 14-23 microtubule associated protein tau Homo sapiens 68-71 20671618-0 2010 Delta6 desaturase as the target of the beneficial actions of magnesium. Magnesium 61-70 fatty acid desaturase 2 Homo sapiens 0-17 20435075-5 2010 The metal ion magnesium (a co-factor for endonuclease) enhanced the Tau DNA nicking ability, while an endonuclease specific inhibitor, aurinetricarboxylic acid (ATA) inhibited the Tau DNA nicking ability. Magnesium 14-23 microtubule associated protein tau Homo sapiens 180-183 20410362-7 2010 We found that extracellular magnesium ([Mg](o)) strongly blocks SCN NMDARs exhibiting affinities and voltage sensitivities associated with NR2A and NR2B subunits. Magnesium 28-37 glutamate receptor, ionotropic, NMDA2A (epsilon 1) Mus musculus 139-143 20182393-5 2010 Proliferation in 3D is also Mg-dependent, but maximal when Mg is present at concentrations that promote maximal cell adhesion and Ca is present at concentrations less than Mg. Immunoblotting studies demonstrate that the divalent cation-dependent changes in cell-cell adhesion observed on type I collagen in both 2D and 3D are associated with the changes in E-cadherin and beta-catenin expression. Magnesium 59-61 cadherin 1 Homo sapiens 357-367 20182393-5 2010 Proliferation in 3D is also Mg-dependent, but maximal when Mg is present at concentrations that promote maximal cell adhesion and Ca is present at concentrations less than Mg. Immunoblotting studies demonstrate that the divalent cation-dependent changes in cell-cell adhesion observed on type I collagen in both 2D and 3D are associated with the changes in E-cadherin and beta-catenin expression. Magnesium 59-61 catenin beta 1 Homo sapiens 372-384 20545343-2 2010 Different chelating agents (phosvitin and gluconate) were used to bind magnesium within the prospect of improving the ion retention in the internal aqueous droplets. Magnesium 71-80 casein kinase 2 beta Homo sapiens 28-37 20512113-3 2010 The structures of p97 N-D1 fragments bearing IBMPFD mutations adopt an atypical N-domain conformation in the presence of Mg(2+).ATPgammaS, which is reversible by ADP, showing for the first time the nucleotide-dependent conformational change of the N-domain. Magnesium 121-123 melanotransferrin Homo sapiens 18-21 19665241-10 2010 Using regression analysis, independent variables significantly associated with serum magnesium levels were serum albumin, calcium, potassium, urea levels, chronic renal failure (CRF), chronic heart failure (CHF), diabetes mellitus (DM) and diuretic drugs (R(2)=0.877). Magnesium 85-94 albumin Homo sapiens 107-120 20673208-6 2010 The truncated monomer of nucleophosmin (represented only by the extractable part of the protein) on addition of magnesium ions to low ionic strength buffer or increase in buffer ionic strength was shown to form oligomers with molecular weights (210-230 kDa) similar to those revealed in the total cell lysate. Magnesium 112-121 nucleophosmin 1 Homo sapiens 25-38 20645688-5 2010 Management of the CTCL population requires vigilence to prevent infection with skin contaminants, and monitoring of potassium and magnesium, electrolytes found to be low in a large proportion of patients. Magnesium 130-139 TSPY like 2 Homo sapiens 18-22 20309841-9 2010 The three-way ANOVA showed that the changes in LPO induced by in vitro treatment of kidney supernatants with exogenous Fe or V or Mg (600, 800 and 1000 microm) were a consequence of independent action of those metals and they also resulted from the interactions between exogenous Fe (Fe(exog)) and endogenous V (V(end)) and between V(end) and exogenous V (V(exog)). Magnesium 130-132 lactoperoxidase Rattus norvegicus 47-50 20309841-15 2010 per 24 h) neither reduced nor intensified the spontaneous LPO, compared with V-only intoxicated animals; however, the stimulating effect of Mg on LPO was revealed in in vitro conditions. Magnesium 140-142 lactoperoxidase Rattus norvegicus 146-149 20155807-7 2010 In addition, a cycloheximide chase assay demonstrated that the degradation of Flag-HO-1 protein was slowed by MG-132. Magnesium 110-112 heme oxygenase 1 Homo sapiens 83-87 20563633-3 2010 ESR titrations showed that 2 mol of SL-ATP readily bound per mole of MRP3 with a dissociation constant of about 100 microM in the presence of Mg(2+) ions. Magnesium 142-144 ATP binding cassette subfamily C member 3 Homo sapiens 69-73 20591188-5 2010 We show just as in these polymerases, Thg1 possesses an active site with three acidic residues that chelate Mg++ cations. Magnesium 108-112 TSC22 domain family member 4 Homo sapiens 38-42 21114028-4 2010 RESULTS: Compared with DM treated alone group (27.29% +/- 2.41%), the apoptotic cell rate in MG-132 + DM group (19.94% +/- 2.07%) was increased (P < 0.05), bcl-2 expression was enhanced [(0.43 +/- 0.06) vs. (2.01 +/- 0.23)] (P < 0.05) and the activity of Caspase-3 was decreased significantly (P < 0.05) in MG-132 treated 2h plus DM group [(4.55 +/- 0.46) vs.(3.73 +/- 0.35)]. Magnesium 93-95 BCL2, apoptosis regulator Rattus norvegicus 159-164 21114028-4 2010 RESULTS: Compared with DM treated alone group (27.29% +/- 2.41%), the apoptotic cell rate in MG-132 + DM group (19.94% +/- 2.07%) was increased (P < 0.05), bcl-2 expression was enhanced [(0.43 +/- 0.06) vs. (2.01 +/- 0.23)] (P < 0.05) and the activity of Caspase-3 was decreased significantly (P < 0.05) in MG-132 treated 2h plus DM group [(4.55 +/- 0.46) vs.(3.73 +/- 0.35)]. Magnesium 93-95 caspase 3 Rattus norvegicus 261-270 20546583-5 2010 Magnesium deficiency, on the other hand, was associated with an increase in production of IL-13 by 80%; 95% CI: 31% to 371% and a reduction in IFN-gamma production. Magnesium 0-9 interleukin 13 Homo sapiens 90-95 20546583-5 2010 Magnesium deficiency, on the other hand, was associated with an increase in production of IL-13 by 80%; 95% CI: 31% to 371% and a reduction in IFN-gamma production. Magnesium 0-9 interferon gamma Homo sapiens 143-152 20532038-2 2010 In this study, light-scattering spectroscopy revealed that stacking of thylakoids isolated from wild type Arabidopsis and the mutant lacking STN7 protein kinase was highly influenced by cation (Mg(++)) concentrations. Magnesium 194-200 Serine/Threonine kinase domain protein Arabidopsis thaliana 141-145 20532038-3 2010 The stacking of thylakoids from the stn8 and stn7stn8 mutants, deficient in STN8 kinase and consequently in light-dependent phosphorylation of PSII, was increased even in the absence of Mg(++). Magnesium 186-192 Protein kinase superfamily protein Arabidopsis thaliana 36-40 20532038-3 2010 The stacking of thylakoids from the stn8 and stn7stn8 mutants, deficient in STN8 kinase and consequently in light-dependent phosphorylation of PSII, was increased even in the absence of Mg(++). Magnesium 186-192 Serine/Threonine kinase domain protein Arabidopsis thaliana 45-53 20410362-7 2010 We found that extracellular magnesium ([Mg](o)) strongly blocks SCN NMDARs exhibiting affinities and voltage sensitivities associated with NR2A and NR2B subunits. Magnesium 28-37 glutamate receptor, ionotropic, NMDA2B (epsilon 2) Mus musculus 148-152 20378487-8 2010 Furthermore, we observed evidence of an interaction between drinking water NO3-N and Mg intake via drinking water. Magnesium 85-87 NBL1, DAN family BMP antagonist Homo sapiens 75-78 20378487-9 2010 This is the first study to report effect modification by Mg intake from drinking water on the association between NO3-N exposure and colon cancer risk. Magnesium 57-59 NBL1, DAN family BMP antagonist Homo sapiens 114-117 20460213-0 2010 Oral magnesium supplementation decreases alanine aminotransferase levels in obese women. Magnesium 5-14 glutamic--pyruvic transaminase Homo sapiens 41-65 20507838-0 2010 The relationship between concentrations of magnesium and oxidized low density lipoprotein and the activity of platelet activating factor acetylhydrolase in the serum of patients with type 1 diabetes. Magnesium 43-52 phospholipase A2 group VII Homo sapiens 110-152 20507838-1 2010 The study was aimed at comparing the concentration of metabolic parameters, the serum concentration of oxidized low density lipoproteins (oxLDL) and the activity of platelet activating factor acetylhydrolase (PAF-AH) in the relation to the serum concentration of magnesium (Mg) in patients with type 1 diabetes (DM1). Magnesium 263-272 phospholipase A2 group VII Homo sapiens 165-207 20507838-1 2010 The study was aimed at comparing the concentration of metabolic parameters, the serum concentration of oxidized low density lipoproteins (oxLDL) and the activity of platelet activating factor acetylhydrolase (PAF-AH) in the relation to the serum concentration of magnesium (Mg) in patients with type 1 diabetes (DM1). Magnesium 263-272 phospholipase A2 group VII Homo sapiens 209-215 20507838-9 2010 Therefore, the oxidative modification of LDL and the higher activity of PAF-AH are related with the low Mg status; however, no relation has been observed between these parameters and the poor metabolic control in DM1 patients. Magnesium 104-106 phospholipase A2 group VII Homo sapiens 72-78 20519162-0 2010 Splice-variant 1 of the ancient domain protein 2 (ACDP2) complements the magnesium-deficient growth phenotype of Salmonella enterica sv. Magnesium 73-82 cyclin and CBS domain divalent metal cation transport mediator 2 Homo sapiens 50-55 20531272-0 2010 Beneficial effects of oral magnesium supplementation on insulin sensitivity and serum lipid profile. Magnesium 27-36 insulin Homo sapiens 56-63 20338184-11 2010 Glutathione-S-transferase pull-down and coimmunoprecipitation assays showed that CA-MEK1 and DN-MEK1 binds with ERK1/2 in the presence of Mg(2+). Magnesium 138-140 mitogen-activated protein kinase 1 Canis lupus familiaris 112-118 19629403-6 2010 Chronic magnesium deficiency has been associated with the development of insulin resistance. Magnesium 8-17 insulin Homo sapiens 73-80 20463899-0 2010 Drosophila TRPM channel is essential for the control of extracellular magnesium levels. Magnesium 70-79 Transient receptor potential cation channel, subfamily M Drosophila melanogaster 11-15 20222016-8 2010 Therefore, the PTH (1-34) administration mode appears to distinctly modulate the migratory responses of the MG-63 moderately and Saos 2 well-differentiated osteosarcoma cell lines. Magnesium 108-110 parathyroid hormone Homo sapiens 15-18 20077113-4 2010 Uncharged tRNA plays an important role in the activation of Gcn2, although we found that MG treatment did not elevate the levels of uncharged tRNA. Magnesium 89-91 serine/threonine-protein kinase GCN2 Saccharomyces cerevisiae S288C 60-64 20097255-3 2010 NR3A-containing NMDARs display striking regional and temporal expression specificity, and, unlike most other NMDAR subtypes, they have a low conductance, are only modestly permeable to Ca(2+), and pass current at hyperpolarized potentials in the presence of magnesium. Magnesium 258-267 glutamate ionotropic receptor NMDA type subunit 3A Homo sapiens 0-4 20593142-11 2010 Significant improvements to the erythrocyte ATPase and cardiac markers in patients treated with Mg/NAC correlated with a reduction in postoperative abnormalities. Magnesium 96-98 dynein axonemal heavy chain 8 Homo sapiens 44-50 19937979-1 2010 Transient receptor potential melastatin 6 (TRPM6) channel is involved in the reabsorption of magnesium in the kidney. Magnesium 93-102 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-41 20424264-1 2010 All known protein kinases, except CASK [calcium/calmodulin (CaM)-activated serine-threonine kinase], require magnesium ions (Mg(2+)) to stimulate the transfer of a phosphate from adenosine 5"-triphosphate (ATP) to a protein substrate. Magnesium 109-118 calcium/calmodulin dependent serine protein kinase Homo sapiens 34-38 20230017-1 2010 The magnesium molecules Mg(2), Mg(3), Mg(4), and Mg(5) have been isolated in rare-gas matrixes at 8 K and characterized for the first time by Raman spectroscopy. Magnesium 4-13 mucin 7, secreted Homo sapiens 24-29 20205471-0 2010 Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2). Magnesium 47-56 leucine rich repeat kinase 2 Homo sapiens 83-111 20205471-0 2010 Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2). Magnesium 47-56 leucine rich repeat kinase 2 Homo sapiens 113-118 20145248-0 2010 Distinct modulations of human capsaicin receptor by protons and magnesium through different domains. Magnesium 64-73 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-48 20145248-5 2010 Human TRPV1 (hTRPV1), a species ortholog with high homology to rTRPV1, is potentiated by extracellular protons and magnesium, even at saturating capsaicin. Magnesium 115-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 6-11 20145248-5 2010 Human TRPV1 (hTRPV1), a species ortholog with high homology to rTRPV1, is potentiated by extracellular protons and magnesium, even at saturating capsaicin. Magnesium 115-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-19 20145248-5 2010 Human TRPV1 (hTRPV1), a species ortholog with high homology to rTRPV1, is potentiated by extracellular protons and magnesium, even at saturating capsaicin. Magnesium 115-124 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 63-69 20145248-9 2010 In contrast, hTRPV1 TM5-6 is required for magnesium augmentation of capsaicin efficacy. Magnesium 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-19 20145248-9 2010 In contrast, hTRPV1 TM5-6 is required for magnesium augmentation of capsaicin efficacy. Magnesium 42-51 tropomyosin 3 Homo sapiens 20-23 20145248-10 2010 Our results demonstrate that capsaicin efficacy of hTRPV1 correlates with the extracellular ion milieu and unravel the relevant structural basis of modulation by protons and magnesium. Magnesium 174-183 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-57 20450628-9 2010 RESULTS: In MG-132 group, the levels of serum amylase (U/L) and sICAM-1 (pg/ml) markedly decreased in comparison with AP group (1629 +/- 59, 1794 +/- 123, 2910 +/- 152 vs 1282 +/- 61, 1525 +/- 103, 1809 +/- 117, 133 +/- 10, 157 +/- 10, 217 +/- 43 vs 106 +/- 6, 135 +/- 4, 163 +/- 19, P < 0.05 or P < 0.01); the scores of pathological changes decreased in pancreas (5.7 +/- 1.0, 7.1 +/- 1.2, 9.6 +/- 2.1 vs 3.2 +/- 1.0, 5.3 +/- 1.0, 6.9 +/- 0.8, P < 0.05 or P < 0.01);the expression of NF-kappaB protein (3.8 +/- 1.1, 4.6 +/- 1.2, 6.7 +/- 0.4 vs 1.9 +/- 0.6, 3.1 +/- 1.0, 4.7 +/- 1.0, P < 0.05 or P < 0.01) were significantly lowered than those in AP group. Magnesium 12-14 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 497-506 20221407-0 2010 Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. Magnesium 0-9 Gon-Two Like (TRP subfamily) Caenorhabditis elegans 63-68 20221407-2 2010 In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. Magnesium 40-49 Transient receptor potential channel Caenorhabditis elegans 118-123 20221407-2 2010 In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. Magnesium 40-49 LSDAT_euk domain-containing protein Caenorhabditis elegans 128-133 20221407-3 2010 In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Magnesium 166-175 Gon-Two Like (TRP subfamily) Caenorhabditis elegans 82-87 20048154-2 2010 Activation of TRPM7 channels has been shown to be involved in cellular Mg(2+) homeostasis, diseases caused by abnormal magnesium absorption, and in Ca(2+)-mediated neuronal injury under ischemic conditions. Magnesium 119-128 transient receptor potential cation channel subfamily M member 7 Homo sapiens 14-19 19914201-10 2010 The phosphothreonine levels of T225A and T233A claudin-16 were decreased in the presence of Mg(2+) and these mutants were widely distributed in the plasma membrane. Magnesium 92-94 claudin 16 Canis lupus familiaris 47-57 20064792-9 2010 For men with the 20% lowest dietary magnesium intake, an inverse association was observed between tap water magnesium intake and stroke mortality (HR per 1 mg/L intake = 0.75; 95% CI, 0.610.91), whereas for women with the 20% lowest dietary magnesium intake, the opposite was observed. Magnesium 108-117 nuclear RNA export factor 1 Homo sapiens 98-101 20064792-9 2010 For men with the 20% lowest dietary magnesium intake, an inverse association was observed between tap water magnesium intake and stroke mortality (HR per 1 mg/L intake = 0.75; 95% CI, 0.610.91), whereas for women with the 20% lowest dietary magnesium intake, the opposite was observed. Magnesium 108-117 nuclear RNA export factor 1 Homo sapiens 98-101 22993543-5 2010 Intravenous magnesium supplementation on the day of anti-EGFR treatment did not always adequately control the magnesium wasting in these patients. Magnesium 12-21 epidermal growth factor receptor Homo sapiens 57-61 20033706-4 2010 RESULTS AND DISCUSSION: The protein FHIT catalyzes the Mg(2+) dependent hydrolysis of P1-5 cent-O-adenosine-P3-5 cent-O-adenosine triphosphate, Ap3A, to AMP, and ADP. Magnesium 55-57 fragile histidine triad diadenosine triphosphatase Homo sapiens 36-40 19937979-1 2010 Transient receptor potential melastatin 6 (TRPM6) channel is involved in the reabsorption of magnesium in the kidney. Magnesium 93-102 transient receptor potential cation channel subfamily M member 6 Homo sapiens 43-48 19899171-8 2010 Whether magnesium ions can play a role in the complex cycle of LDLR internalization and recycling is not known. Magnesium 8-17 low density lipoprotein receptor Homo sapiens 63-67 19899171-12 2010 While the mildly acidic and calcium-depleted environment in late endosomes has been proposed to contribute significantly to LDL release, the presence of magnesium might assist in efficient LDLR recycling. Magnesium 153-162 low density lipoprotein receptor Homo sapiens 189-193 20350433-0 2010 [Effect of magnesium-free on glucocorticoid receptor expression in primary cultured cortical neurons of fetal rats in vitro]. Magnesium 11-20 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 29-52 20350433-7 2010 CONCLUSIONS: GR expression is modified following Mg-free-induced injury in cultured developing neurons in rats. Magnesium 49-51 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 13-15 20117086-4 2010 Addition of anti-CaSR antibodies completely blocked the effect, while CaSR agonist Mg(2+) produced a similar response to that of calcium. Magnesium 83-85 calcium sensing receptor Homo sapiens 70-74 20104875-4 2010 In the presence of 20 mM Mg(2+), activated IRAK-4 herein is demonstrated to phosphorylate a peptide substrate (IRAK-1 peptide), derived from the activation loop of IRAK-1, with a k(cat) of 30 +/- 2.9 s(-1) and K(m) values of 668 +/- 120 and 852 +/- 273 microM for ATP and the peptide, respectively. Magnesium 25-27 interleukin 1 receptor associated kinase 4 Homo sapiens 43-49 20104875-4 2010 In the presence of 20 mM Mg(2+), activated IRAK-4 herein is demonstrated to phosphorylate a peptide substrate (IRAK-1 peptide), derived from the activation loop of IRAK-1, with a k(cat) of 30 +/- 2.9 s(-1) and K(m) values of 668 +/- 120 and 852 +/- 273 microM for ATP and the peptide, respectively. Magnesium 25-27 interleukin 1 receptor associated kinase 1 Homo sapiens 111-117 20104875-4 2010 In the presence of 20 mM Mg(2+), activated IRAK-4 herein is demonstrated to phosphorylate a peptide substrate (IRAK-1 peptide), derived from the activation loop of IRAK-1, with a k(cat) of 30 +/- 2.9 s(-1) and K(m) values of 668 +/- 120 and 852 +/- 273 microM for ATP and the peptide, respectively. Magnesium 25-27 interleukin 1 receptor associated kinase 1 Homo sapiens 164-170 19488681-10 2010 Serum osteocalcin levels were significantly increased (p < 0.001) and urinary deoxypyridinoline levels were decreased (p < 0.001) in the Mg-supplemented group. Magnesium 143-145 bone gamma-carboxyglutamate protein Homo sapiens 6-17 19903755-4 2010 RESULTS: After adjustment for age, ethnicity, clinical center, time of blood draw, smoking, alcohol, physical activity, energy intake, BMI, and diabetes status, magnesium intake was inversely associated with hs-CRP (P for linear trend = 0.003), IL-6 (P < 0.0001), TNF-alpha-R2 (P = 0.0006), and sVCAM-1 (P = 0.06). Magnesium 161-170 interleukin 6 Homo sapiens 245-249 19903755-6 2010 Multivariable-adjusted geometric means across increasing quintiles of magnesium intake were 3.08, 2.63, 2.31, 2.53, and 2.16 mg/l for hs-CRP (P = 0.005); 2.91, 2.63, 2.45, 2.27, and 2.26 pg/ml for IL-6 (P = 0.0005); and 707, 681, 673, 671, and 656 ng/ml for sVCAM-1 (P = 0.04). Magnesium 70-79 interleukin 6 Homo sapiens 197-201 19903755-7 2010 An increase of 100 mg/day magnesium was inversely associated with hs-CRP (-0.23 mg/l +/- 0.07; P = 0.002), IL-6 (-0.14 +/- 0.05 pg/ml; P = 0.004), TNF-alpha-R2 (-0.04 +/- 0.02 pg/ml; P = 0.06), and sVCAM-1 (-0.04 +/- 0.02 ng/ml; P = 0.07). Magnesium 26-35 interleukin 6 Homo sapiens 107-111 19939631-5 2010 Application of DHK or TBOA markedly reduced the frequency of epileptiform discharges in CA1 in the low magnesium and the 4-AP model while pathological activity was increased in the penicillin-model. Magnesium 103-112 carbonic anhydrase 1 Rattus norvegicus 88-91 19890837-0 2010 Modulation of TRPM6 and Na(+)/Mg(2+) exchange in mammary epithelial cells in response to variations of magnesium availability. Magnesium 103-112 transient receptor potential cation channel subfamily M member 6 Homo sapiens 14-19 19890837-6 2010 Surprisingly, we found that cells grown in low magnesium upregulated mRNA for the magnesium channel TRPM6, but not for other channels like TRPM7 or MagT1. Magnesium 47-56 transient receptor potential cation channel subfamily M member 6 Homo sapiens 100-105 19890837-7 2010 TRPM6 mRNA was also rapidly upregulated or downregulated in HC11 cells deprived of magnesium or in low-magnesium cells re-added with magnesium, respectively. Magnesium 83-92 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 19890837-7 2010 TRPM6 mRNA was also rapidly upregulated or downregulated in HC11 cells deprived of magnesium or in low-magnesium cells re-added with magnesium, respectively. Magnesium 83-92 C-C motif chemokine ligand 2 Homo sapiens 60-64 19890837-7 2010 TRPM6 mRNA was also rapidly upregulated or downregulated in HC11 cells deprived of magnesium or in low-magnesium cells re-added with magnesium, respectively. Magnesium 103-112 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 19890837-7 2010 TRPM6 mRNA was also rapidly upregulated or downregulated in HC11 cells deprived of magnesium or in low-magnesium cells re-added with magnesium, respectively. Magnesium 103-112 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 19890837-9 2010 We propose that mammary epithelial cells adapt to decreased magnesium availability by upregulating magnesium influx via TRPM6, and counteract increased magnesium availability by increasing magnesium efflux primarily via Na(+)/Mg(2+) exchange. Magnesium 99-108 transient receptor potential cation channel subfamily M member 6 Homo sapiens 120-125 19890837-9 2010 We propose that mammary epithelial cells adapt to decreased magnesium availability by upregulating magnesium influx via TRPM6, and counteract increased magnesium availability by increasing magnesium efflux primarily via Na(+)/Mg(2+) exchange. Magnesium 99-108 transient receptor potential cation channel subfamily M member 6 Homo sapiens 120-125 19890837-9 2010 We propose that mammary epithelial cells adapt to decreased magnesium availability by upregulating magnesium influx via TRPM6, and counteract increased magnesium availability by increasing magnesium efflux primarily via Na(+)/Mg(2+) exchange. Magnesium 99-108 transient receptor potential cation channel subfamily M member 6 Homo sapiens 120-125 19890837-10 2010 These results show, for the first time, that TRPM6 contributes to regulating magnesium influx in mammary epithelial cells, similar to what is known for intestine and kidney. Magnesium 77-86 transient receptor potential cation channel subfamily M member 6 Homo sapiens 45-50 20050588-7 2010 The relative metal ion affinities of OT were found to be responsible for the relative effectiveness of divalent metal ions for the OT activation, which were in the order of Co(2+) > Ni(2+) > Mg(2+) > Zn(2+), with a minimal effect by Ca(2+). Magnesium 197-199 oxytocin/neurophysin I prepropeptide Homo sapiens 37-39 20050588-7 2010 The relative metal ion affinities of OT were found to be responsible for the relative effectiveness of divalent metal ions for the OT activation, which were in the order of Co(2+) > Ni(2+) > Mg(2+) > Zn(2+), with a minimal effect by Ca(2+). Magnesium 197-199 oxytocin/neurophysin I prepropeptide Homo sapiens 131-133 19919525-0 2009 TNFalpha receptor knockout in mice reduces adverse effects of magnesium deficiency on bone. Magnesium 62-71 tumor necrosis factor Mus musculus 0-8 19405049-3 2010 The T1482I variant (rs8042919) of TRPM7 gene which is suggested to play roles in regulating the cellular homeostasis of Ca(2+), Mg(2+), and trace metals, has recently been reported to be associated with Guamanian patients with ALS/PDC. Magnesium 128-130 transient receptor potential cation channel subfamily M member 7 Homo sapiens 34-39 19405049-3 2010 The T1482I variant (rs8042919) of TRPM7 gene which is suggested to play roles in regulating the cellular homeostasis of Ca(2+), Mg(2+), and trace metals, has recently been reported to be associated with Guamanian patients with ALS/PDC. Magnesium 128-130 phosducin Homo sapiens 231-234 21348392-13 2010 We observed an inverse correlation between serum magnesium and hs-CRP (r = -0.37, p = 0.02) in PD patients. Magnesium 49-58 C-reactive protein Homo sapiens 66-69 20199997-4 2010 Through different mechanisms, some components of nuts such as magnesium, fiber, alpha-linolenic acid, L-arginine, antioxidants and MUFA may protect against inflammation and insulin resistance. Magnesium 62-71 insulin Homo sapiens 173-180 20662476-5 2010 From thyroid gland calcitonin is released namely by calcium and magnesium. Magnesium 64-73 calcitonin related polypeptide alpha Homo sapiens 19-29 19882675-10 2010 Stimulation of the Wnt/beta-catenin pathway by GIN significantly reduced cell proliferation in the cell lines MG-63 and U-2-OS and enhanced differentiation in the cell lines HOS and SJSA-1, as shown by an increase in alkaline phosphatase (ALP) activity and mineralization. Magnesium 110-112 catenin beta 1 Homo sapiens 23-35 20099195-8 2010 Conversely, lower beta -glucuronidase activity was significantly associated with higher intakes of calcium, iron, and magnesium. Magnesium 118-127 glucuronidase beta Homo sapiens 18-37 19919525-5 2009 We have previously demonstrated an increase in TNFalpha in bone from Mg deficient rodents. Magnesium 69-71 tumor necrosis factor Mus musculus 47-55 19890040-1 2009 Complement factor B (fB) circulates in plasma as a proenzyme that, upon binding to C3b in the presence of Mg(2+), is cleaved by factor D to produce Ba and Bb fragments. Magnesium 106-108 complement factor B Homo sapiens 0-19 19359148-0 2009 Effects of oral magnesium supplementation on insulin sensitivity and blood pressure in normo-magnesemic nondiabetic overweight Korean adults. Magnesium 16-25 insulin Homo sapiens 45-52 19359148-1 2009 BACKGROUND AND AIM: Little is known about the effect of magnesium on insulin sensitivity and BP in healthy individuals. Magnesium 56-65 insulin Homo sapiens 69-76 19359148-2 2009 Therefore, we investigated whether magnesium could improve insulin sensitivity and blood pressure (BP) in normo-magnesemic nondiabetic overweight adults. Magnesium 35-44 insulin Homo sapiens 59-66 19966073-7 2009 A strong, magnesium-dependent phenotype of growth retardation was found for mrs2-7 when Mg(2+) concentrations were lowered to 50 microM in hydroponic cultures. Magnesium 10-19 magnesium transporter 7 Arabidopsis thaliana 76-82 19750528-1 2009 Kinetic and spectroscopic analyses were performed to gain information about the mechanism of atom-transfer radical reactions catalyzed by the complexes [RuCl2Cp*(PPh3)] and [RuClCp*(PPh3)2] (Cp*=pentamethylcyclopentadienyl), in the presence and in the absence of the reducing agent magnesium. Magnesium 282-291 caveolin 1 Homo sapiens 162-166 19692351-10 2009 Trpm6(+/-) mice had normal electrolytes except for modestly low plasma [Mg]. Magnesium 72-74 transient receptor potential cation channel, subfamily M, member 6 Mus musculus 0-5 19901987-5 2009 In the crystal, the hu3S193 Fab molecules are coordinated at their protein-protein interface by two zinc ions and in solution aggregation of Fab can be initiated by zinc, but not magnesium ions. Magnesium 179-188 FA complementation group B Homo sapiens 28-31 19750528-1 2009 Kinetic and spectroscopic analyses were performed to gain information about the mechanism of atom-transfer radical reactions catalyzed by the complexes [RuCl2Cp*(PPh3)] and [RuClCp*(PPh3)2] (Cp*=pentamethylcyclopentadienyl), in the presence and in the absence of the reducing agent magnesium. Magnesium 282-291 caveolin 1 Homo sapiens 182-186 19754085-1 2009 A kinetic study of the aroxyl (ArO*) radical-scavenging reaction of alpha-tocopherol (alpha-TocH) has been performed in the presence of six kinds of alkali and alkaline earth metal salts (LiI, LiClO(4), NaI, NaClO(4), KI, and Mg(ClO(4))(2)) in methanol solution, using stopped-flow spectrophotometry. Magnesium 226-228 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 31-35 19274447-5 2009 The results showed that the chlorophyll synthesis and oxygen evolution was destroyed, and the activities of Rubisco carboxylasae and Rubisco activase and the expression of Rubisco large subunit (rbcL), Rubisco small subunit (rbcS), and Rubisco activase subunit (rca) were significantly inhibited, then plant growth was inhibited by magnesium deficiency. Magnesium 332-341 RuBisCO large subunit Spinacia oleracea 195-199 19686285-2 2009 Here, we found that the level of germinal center-associated nuclear protein (GANP), a mammalian homologue of yeast Sac3, was markedly decreased in MGs with a poor prognosis; and thus we explored the effect of its decrease on cell-cycle progression of MG cell lines. Magnesium 147-150 minichromosome maintenance complex component 3 associated protein Homo sapiens 33-75 19686285-2 2009 Here, we found that the level of germinal center-associated nuclear protein (GANP), a mammalian homologue of yeast Sac3, was markedly decreased in MGs with a poor prognosis; and thus we explored the effect of its decrease on cell-cycle progression of MG cell lines. Magnesium 147-150 minichromosome maintenance complex component 3 associated protein Homo sapiens 77-81 19686285-2 2009 Here, we found that the level of germinal center-associated nuclear protein (GANP), a mammalian homologue of yeast Sac3, was markedly decreased in MGs with a poor prognosis; and thus we explored the effect of its decrease on cell-cycle progression of MG cell lines. Magnesium 147-150 Sac3p Saccharomyces cerevisiae S288C 115-119 19695239-7 2009 RESULTS: We found a significant association between estrogen receptor alpha (ESR1) polymorphisms, PvuII and XbaI, and magnesium (r=-0.116, p=0.012 and r=-0.126, p=0.006, respectively). Magnesium 118-127 estrogen receptor 1 Homo sapiens 52-75 19695239-7 2009 RESULTS: We found a significant association between estrogen receptor alpha (ESR1) polymorphisms, PvuII and XbaI, and magnesium (r=-0.116, p=0.012 and r=-0.126, p=0.006, respectively). Magnesium 118-127 estrogen receptor 1 Homo sapiens 77-81 19695239-10 2009 CONCLUSIONS: The significant association between magnesium and ESR1 polymorphisms supports previous studies linking physiologic changes in serum magnesium to estrogen status. Magnesium 49-58 estrogen receptor 1 Homo sapiens 63-67 19695239-10 2009 CONCLUSIONS: The significant association between magnesium and ESR1 polymorphisms supports previous studies linking physiologic changes in serum magnesium to estrogen status. Magnesium 145-154 estrogen receptor 1 Homo sapiens 63-67 19720860-0 2009 MNR2 regulates intracellular magnesium storage in Saccharomyces cerevisiae. Magnesium 29-38 putative Mg(2+) transporter MNR2 Saccharomyces cerevisiae S288C 0-4 19720860-3 2009 We describe a fifth yeast CorA homolog (Mnr2) required for Mg homeostasis. Magnesium 59-61 putative Mg(2+) transporter MNR2 Saccharomyces cerevisiae S288C 40-44 19720860-4 2009 MNR2 gene inactivation was associated with an increase in both the Mg requirement and the Mg content of yeast cells. Magnesium 67-69 putative Mg(2+) transporter MNR2 Saccharomyces cerevisiae S288C 0-4 19720860-4 2009 MNR2 gene inactivation was associated with an increase in both the Mg requirement and the Mg content of yeast cells. Magnesium 90-92 putative Mg(2+) transporter MNR2 Saccharomyces cerevisiae S288C 0-4 19720860-6 2009 An mnr2 mutant was unable to access this store, suggesting that Mg was trapped in an intracellular compartment. Magnesium 64-66 putative Mg(2+) transporter MNR2 Saccharomyces cerevisiae S288C 3-7 19720860-7 2009 Mnr2 was localized to the vacuole membrane, implicating this organelle in Mg storage. Magnesium 74-76 putative Mg(2+) transporter MNR2 Saccharomyces cerevisiae S288C 0-4 19769410-6 2009 Using structure-based molecular docking of Fen1 targeted to its metal binding pocket M2 (Mg(2+) site), we have identified a potent low-molecular weight inhibitor (LMI, NSC-281680) that efficiently blocks LP-BER. Magnesium 89-91 flap structure-specific endonuclease 1 Homo sapiens 43-47 19754085-3 2009 The second-order rate constants (k(s)) for the reaction of alpha-TocH with ArO* increased in the order of no metal salt < KI approximately NaClO(4) approximately NaI <or= LiClO(4) < Mg(ClO(4))(2) < LiI at the same concentration of metal salts. Magnesium 191-193 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 75-79 19399595-9 2009 Association constant (Ka) calculations suggest atm has two orders of magnitude stronger chelation for divalent magnesium than for calcium. Magnesium 111-120 ATM serine/threonine kinase Homo sapiens 47-50 19656910-9 2009 Sirolimus treatment reduced expression of NKCC2, and this was accompanied by greater urinary excretion of sodium, potassium, and magnesium. Magnesium 129-138 solute carrier family 12 member 1 Rattus norvegicus 42-47 19717468-0 2009 Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Magnesium 52-61 magnesium transporter 1 Homo sapiens 10-15 19717468-0 2009 Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Magnesium 52-61 tumor suppressor candidate 3 Homo sapiens 20-25 19717468-4 2009 MagT1 is universally expressed in all human tissues and its expression level is up-regulated in low extracellular Mg(2+). Magnesium 114-116 magnesium transporter 1 Homo sapiens 0-5 19745154-4 2009 Magnesium exclusion, a critical factor in promoting GDP release, is mediated by a conserved valine residue within this sensor, whereas binding of GTP-Mg2+ to the nucleotide-free complex results in magnesium-inducing displacement of the sensor to stimulate discharge of Cdc42-GTP. Magnesium 0-9 cell division cycle 42 Homo sapiens 269-274 19745154-4 2009 Magnesium exclusion, a critical factor in promoting GDP release, is mediated by a conserved valine residue within this sensor, whereas binding of GTP-Mg2+ to the nucleotide-free complex results in magnesium-inducing displacement of the sensor to stimulate discharge of Cdc42-GTP. Magnesium 197-206 cell division cycle 42 Homo sapiens 269-274 19706394-0 2009 Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. Magnesium 120-129 claudin 16 Mus musculus 0-10 19706394-0 2009 Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. Magnesium 120-129 claudin 19 Mus musculus 15-25 19706394-4 2009 Here, we show that CLDN19-siRNA mice also developed the FHHNC symptoms of chronic renal wasting of magnesium and calcium together with defective renal salt handling. Magnesium 99-108 claudin 19 Mus musculus 19-25 19540199-6 2009 In this connection, MG-132 reduced the phosphorylation of mammalian target of rapamycin (mTOR) at Ser2448 and Ser2481 and the phosphorylation of its downstream targets 4E-BP1 and p70/p85 S6 kinases. Magnesium 20-22 mechanistic target of rapamycin kinase Homo sapiens 58-87 19540199-6 2009 In this connection, MG-132 reduced the phosphorylation of mammalian target of rapamycin (mTOR) at Ser2448 and Ser2481 and the phosphorylation of its downstream targets 4E-BP1 and p70/p85 S6 kinases. Magnesium 20-22 mechanistic target of rapamycin kinase Homo sapiens 89-93 19540199-6 2009 In this connection, MG-132 reduced the phosphorylation of mammalian target of rapamycin (mTOR) at Ser2448 and Ser2481 and the phosphorylation of its downstream targets 4E-BP1 and p70/p85 S6 kinases. Magnesium 20-22 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 168-174 19540199-6 2009 In this connection, MG-132 reduced the phosphorylation of mammalian target of rapamycin (mTOR) at Ser2448 and Ser2481 and the phosphorylation of its downstream targets 4E-BP1 and p70/p85 S6 kinases. Magnesium 20-22 annexin A6 Homo sapiens 179-182 19580815-3 2009 We show that Ca(2+) is a novel metal cofactor of CSB for ATP hydrolysis, mainly through the enhancement of k(cat), and that a variety of biologically relevant model nucleic acid substrates can function to activate CSB ATPase activity with either Mg(2+) or Ca(2+) present. Magnesium 246-248 ERCC excision repair 6, chromatin remodeling factor Homo sapiens 49-52 19451148-5 2009 The requirements of ATP and Mg for the helicase activity were different from those for the ATPase activity. Magnesium 28-30 helicase for meiosis 1 Homo sapiens 39-47 19451148-5 2009 The requirements of ATP and Mg for the helicase activity were different from those for the ATPase activity. Magnesium 28-30 dynein axonemal heavy chain 8 Homo sapiens 91-97 19617379-1 2009 BACKGROUND: Magnesium is well known to inhibit catecholamine release and attenuate vasopressin-stimulated vasoconstriction. Magnesium 12-21 arginine vasopressin Homo sapiens 83-94 19895308-11 2009 Enzymatic reaction followed by paper chromatography showed that p42 catalyzed the synthesis of glutamine from glutamate in the presence of ammonium ion, ATP, and magnesium ion. Magnesium 162-171 glutamate-ammonia ligase Gallus gallus 64-67 19848120-6 2009 The CAS allows usto distinguish three groups of cations: (a) Al, H, Pb, Hg, and Cr, which are preferentially bound to the phenolic sites of the fulvic ligand; (b) Ca, Mg, Cd, Fe(II), and Mn, which display a greater effective affinity for carboxylic sites, in contrast to what would be expected from their individual complexation parameters; and (c) Fe(III), Cu, Zn, and Ni, for which phenolic and carboxylic distributions are overlapped. Magnesium 167-169 BCAR1 scaffold protein, Cas family member Homo sapiens 4-7 19780404-7 2009 Thus, we submit that inhibition of NEP by pharmacological, genetic and dietary approaches (magnesium restriction), causes greater neurogenic inflammation that may result in increased intestinal and cardiac dysfunction. Magnesium 91-100 membrane metallo-endopeptidase Rattus norvegicus 35-38 19653656-1 2009 The Kir2.1 potassium channel owes its inward-rectifying behavior to blocking by multivalent ions, e.g., magnesium and spermine, which access the channel from the cytoplasm and are thought to bind within the pore. Magnesium 104-113 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 4-10 19721377-8 2009 Claudin-16 is expressed in the tight junction (TJ) of the thick ascending limb of Henle and may be involved in the paracellular Mg(2+) transport. Magnesium 128-130 claudin 16 Homo sapiens 0-10 19715604-1 2009 BACKGROUND: Although magnesium ions (Mg2+) are known to display many similar features to other 2+ charged cations, they seem to have quite an important and unique role in biological settings, such as NMDA blocking effect. Magnesium 21-30 mucin 7, secreted Homo sapiens 37-40 19715604-9 2009 CONCLUSION: Membrane-stabilizing effect and peripheral NMDA-blocking effect possibly produced magnesium-induced mechanical hypesthesia, and extracellular cation-induced sensitization of TRPV1 channels was thought to be the primary mechanism of magnesium-induced heat hyperalgesia. Magnesium 244-253 transient receptor potential cation channel subfamily V member 1 Homo sapiens 186-191 19603830-7 2009 The fibrillation reaction of the Apaf-1 CARD was conducted at pH 2.1 and 60 degrees C, because reduction of exposed hydrophobic surfaces in the MG state is more favored under the moderated solution condition. Magnesium 144-146 apoptotic peptidase activating factor 1 Homo sapiens 33-39 19576448-0 2009 Magnesium effect on the acetylcholinesterase inhibition mechanism: a molecular chromatographic approach. Magnesium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 19576448-1 2009 The acetylcholinesterase enzyme (AChE) was immobilized on a chromatographic support to study the effect of magnesium on the binding mechanism of five AChE inhibitors (donepezil, tacrine, galanthamine, physostigmine and huperzine). Magnesium 107-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 19171197-7 2009 Bovicin HC5 is a positively charged peptide, and the ability of S. bovis JB1 to bind bovicin HC5 could be inhibited by either calcium or magnesium (100 mM). Magnesium 137-146 heterochromatin, Chr 5 Mus musculus 8-11 19171197-7 2009 Bovicin HC5 is a positively charged peptide, and the ability of S. bovis JB1 to bind bovicin HC5 could be inhibited by either calcium or magnesium (100 mM). Magnesium 137-146 heterochromatin, Chr 5 Mus musculus 93-96 19165416-2 2009 Its basic pathogenesis is impaired tubular resorption of magnesium and calcium in the thick ascending limb of the loop of Henle (TAL) due to a genetic defect in paracellin-1 (a tight junction protein expressed in TAL). Magnesium 57-66 leucine rich repeat and sterile alpha motif containing 1 Homo sapiens 129-132 19602045-12 2009 Interestingly, MG-AGE-induced cardiomyocyte dysfunction was associated with mitochondrial membrane potential (MMP) depolarization and reduced GSK-3beta inactivation in control cardiomyocytes, similar to those from in vivo diabetes. Magnesium 15-17 glycogen synthase kinase 3 beta Homo sapiens 142-151 19596806-4 2009 Here, we studied the effects of Mg(i) on voltage-dependent inactivation (VDI) of Ca(v)1.2 channels using Na(+) as permeant ion to eliminate the effects of permeant divalent cations that engage the Ca(2+)-dependent inactivation process. Magnesium 32-34 immunoglobulin lambda variable 2-8 Homo sapiens 81-89 19596806-5 2009 We confirmed that increased Mg(i) reduces peak ionic currents and increases VDI of Ca(v)1.2 channels in ventricular myocytes and in transfected cells when measured with Na(+) as permeant ion. Magnesium 28-30 VDI Homo sapiens 76-79 19596806-5 2009 We confirmed that increased Mg(i) reduces peak ionic currents and increases VDI of Ca(v)1.2 channels in ventricular myocytes and in transfected cells when measured with Na(+) as permeant ion. Magnesium 28-30 immunoglobulin lambda variable 2-8 Homo sapiens 83-91 19711039-0 2009 Basic fibroblast growth factor increases intracellular magnesium concentration through the specific signaling pathways. Magnesium 55-64 fibroblast growth factor 2 Homo sapiens 0-30 19433582-6 2009 Induction of tyrosine hydroxylase, a target of HIF-1, by CoCl(2) injection was suppressed in the adrenal medulla of magnesium-deficient mice because of up-regulation of IPAS. Magnesium 116-125 hypoxia inducible factor 3, alpha subunit Mus musculus 169-173 18795241-4 2009 The enzyme had an optimal temperature of 25 degrees C and was relatively stable at 20-30 degrees C. Reducing sodium metabisulfite, ascorbic acid, dithiothreitol, SnCl(2), and FeCl(3) markedly inhibited PPO activity, whereas its activity was highly enhanced by Mg(2+), Ca(2+), and Mn(2+) and was moderately inhibited by Ba(2+), Cu(2+), and Zn(2+). Magnesium 260-262 polyphenol oxidase, chloroplastic-like Gossypium hirsutum 202-205 19767829-7 2009 We examined the finding that the D288C actin protein does not polymerize under oxidizing conditions and forms protein aggregates when magnesium and EGTA are present. Magnesium 134-143 actin Saccharomyces cerevisiae S288C 39-44 19346293-2 2009 In our recent study, magnesium can also bind to the p53DBD and enhance its DNA-binding activity. Magnesium 21-30 tumor protein p53 Homo sapiens 52-55 19365810-4 2009 Disruption of the proteosome pathway using selective inhibitors (MG-132, MG-115, and epoxomicin) resulted in the accumulation of p62 and CYLD, and altered the subcellular targeting and distribution of p62 and TRAF6 in osteoclast-like cells. Magnesium 65-67 nucleoporin 62 Homo sapiens 129-132 19365810-4 2009 Disruption of the proteosome pathway using selective inhibitors (MG-132, MG-115, and epoxomicin) resulted in the accumulation of p62 and CYLD, and altered the subcellular targeting and distribution of p62 and TRAF6 in osteoclast-like cells. Magnesium 65-67 CYLD lysine 63 deubiquitinase Homo sapiens 137-141 19365810-4 2009 Disruption of the proteosome pathway using selective inhibitors (MG-132, MG-115, and epoxomicin) resulted in the accumulation of p62 and CYLD, and altered the subcellular targeting and distribution of p62 and TRAF6 in osteoclast-like cells. Magnesium 65-67 nucleoporin 62 Homo sapiens 201-204 19365810-4 2009 Disruption of the proteosome pathway using selective inhibitors (MG-132, MG-115, and epoxomicin) resulted in the accumulation of p62 and CYLD, and altered the subcellular targeting and distribution of p62 and TRAF6 in osteoclast-like cells. Magnesium 65-67 TNF receptor associated factor 6 Homo sapiens 209-214 19429813-2 2009 The data indicate that short-term Mg deficiency (10% normal dietary intake) resulted in profound reductions in serum-ionized Mg and total Mg with an elevation in serum-ionized calcium (Ca(2+)), significant lowering of serum SM and serum PC, with concomitant LP, DNA fragmentation, and activation of caspase-3 in ventricular (right and left chambers), atrial (right and left chambers) and abdominal aortic smooth muscle. Magnesium 34-36 caspase 3 Rattus norvegicus 299-308 19429813-3 2009 The greater the reduction in serum-ionized Mg, the greater the effects on DNA fragmentation, LP, and caspase-3 activity. Magnesium 43-45 caspase 3 Rattus norvegicus 101-110 19593099-5 2009 These SP-mediated events may predispose the heart to injury if faced with subsequent oxidative stressors (ischemia/reperfusion, certain drugs) or facilitate development of in situ cardiac dysfunction, especially with prolonged dietary Mg restriction. Magnesium 235-237 tachykinin precursor 1 Homo sapiens 6-8 19034391-6 2009 There was a positive correlation between the serum PBI levels in maternal blood and magnesium concentration in maternal blood in patients with severe preeclampsia (r = 0.41, p < 0.05). Magnesium 84-93 submaxillary gland androgen regulated protein 3A Homo sapiens 51-54 19285387-6 2009 The metal ions Ca(2+), Mg(2+) and Mn(2+) had stimulatory effect on lipase activity, whereas Cu(2+), Fe(2+) and Zn(2+) strongly inhibited the lipase activity. Magnesium 23-25 DM80_RS12985 Burkholderia multivorans 67-73 19375481-4 2009 The affinity for guanosine nucleotides was almost identical to that exhibited by wild-type SsEF-1alpha; vice versa, the GDP exchange rate was one order of magnitude faster on the mutated elongation factor, a property partially restored when the exchange reaction was analysed in the presence of the magnesium ions chelating agent EDTA. Magnesium 299-308 ribosomal protein S18-alanine N-acetyltransferase Saccharolobus solfataricus 91-102 19297420-0 2009 Influence of magnesium ion on the binding of p53 DNA-binding domain to DNA-response elements. Magnesium 13-22 tumor protein p53 Homo sapiens 45-48 19165416-2 2009 Its basic pathogenesis is impaired tubular resorption of magnesium and calcium in the thick ascending limb of the loop of Henle (TAL) due to a genetic defect in paracellin-1 (a tight junction protein expressed in TAL). Magnesium 57-66 claudin 16 Homo sapiens 161-173 19385665-0 2009 Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release . Magnesium 96-105 hypothetical protein Saccharolobus solfataricus 14-52 19530781-0 2009 The nature of interactions between clusters of Mg and Zn with HCN from symmetry-adapted perturbation theory based of DFT. Magnesium 47-49 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 62-65 19203841-5 2009 The latter was shown to cause hypomagnesaemia by impeding EGF-dependent activation of TRPM6, the main cation channel responsible for Mg transcellular absorption in the intestine and kidney. Magnesium 133-135 transient receptor potential cation channel subfamily M member 6 Homo sapiens 86-91 19122649-0 2009 Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-)). Magnesium 17-26 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 Mus musculus 115-120 19103720-1 2009 GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of L-alpha-amino acids, a signaling augmented by the divalent cations Ca(2)(+) and Mg(2)(+). Magnesium 160-162 G protein-coupled receptor, family C, group 6, member A Mus musculus 0-6 19916462-8 2009 Additionally, the diffusion of dissociated H atom on the Mg-terminated MgB2(0001) surface is almost barrier-less. Magnesium 57-59 secretoglobin family 2A member 1 Homo sapiens 71-75 19581665-7 2009 In the past decade our understanding of transcellular magnesium transport was enhanced by the discovery of several gene mutations i.e. transient receptor potential melastin (TR PM) 6 and 7. Magnesium 54-63 transient receptor potential cation channel subfamily M member 6 Homo sapiens 135-188 19721910-2 2009 Finally, he was successfully treated by self-administered subcutaneous magnesium: he reached and maintained normal levels of serum calcium, magnesium and PTH, no more hospital admission were needed and he resumed a normal life. Magnesium 71-80 parathyroid hormone Homo sapiens 154-157 18949482-2 2009 Here, several transport proteins, like the thiazide-sensitive NaCl cotransporter (NCC) and the epithelial magnesium (Mg(2+)) channel (TRPM6), are exclusively expressed. Magnesium 106-115 transient receptor potential cation channel subfamily M member 6 Homo sapiens 134-139 19420534-1 2009 We report on the effect of Mg doping on the properties of GaN nanowires grown by plasma assisted molecular beam epitaxy. Magnesium 27-29 gigaxonin Homo sapiens 58-61 18717645-10 2009 Magnesium ions strongly inhibited the interaction between GST-CREB and TORC1 and this effect was reversed by lithium. Magnesium 0-9 cAMP responsive element binding protein 1 Homo sapiens 62-66 18717645-10 2009 Magnesium ions strongly inhibited the interaction between GST-CREB and TORC1 and this effect was reversed by lithium. Magnesium 0-9 CREB regulated transcription coactivator 1 Homo sapiens 71-76 19271703-0 2009 Magnesium-magnesium bond stabilized by a doubly reduced alpha-diimine: synthesis and structure of [K(THF)3]2[LMg-MgL] (L = [(2,6-(i)Pr2C6H3)NC(Me)]2(2-)). Magnesium 0-9 C-type lectin domain containing 10A Homo sapiens 113-116 18384665-6 2009 We conclude that hMrs2 is the major transport protein for Mg (+) uptake into mitochondria and that expression of hMrs2 is essential for the maintenance of respiratory complex I and cell viability. Magnesium 58-64 magnesium transporter MRS2 Homo sapiens 17-22 19019181-7 2009 Women within the lowest PTH quartile were younger, had lower BMI and magnesium values and higher IGF1 levels and were more likely to smoke. Magnesium 69-78 parathyroid hormone Homo sapiens 24-27 19020533-8 2009 Oral magnesium supplementation with MgCl(2) significantly reduces SBP and DBP in diabetic hypertensive adults with hypomagnesaemia. Magnesium 5-14 selenium binding protein 1 Homo sapiens 66-69 19020533-8 2009 Oral magnesium supplementation with MgCl(2) significantly reduces SBP and DBP in diabetic hypertensive adults with hypomagnesaemia. Magnesium 5-14 D-box binding PAR bZIP transcription factor Homo sapiens 74-77 19059299-10 2009 In conclusion, the present study provides evidence indicating that the antidepressant-like effect of magnesium in the FST is dependent on its interaction with the serotonergic (5-HT(1A) and 5-HT(2A/2C) receptors), noradrenergic (alpha(1)- and alpha(2)- receptors) and dopaminergic (dopamine D(1) and D(2) receptors) systems. Magnesium 101-110 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 177-184 19206206-9 2009 A divalent magnesium metal dependence study established that Btk requires a second magnesium ion for activity. Magnesium 11-20 Bruton tyrosine kinase Homo sapiens 61-64 19206206-9 2009 A divalent magnesium metal dependence study established that Btk requires a second magnesium ion for activity. Magnesium 83-92 Bruton tyrosine kinase Homo sapiens 61-64 19307450-6 2009 Enzyme kinetics of heart AC and recombinant AC5 in the presence of Mg(2+) were similar. Magnesium 67-69 adenylate cyclase 5 Mus musculus 44-47 19658273-3 2009 Recent findings from epidemiologic studies support that magnesium intake is inversely associated with C-reactive protein concentration, an important marker of inflammation strongly associated with cardiovascular disease risk. Magnesium 56-65 C-reactive protein Homo sapiens 102-120 18972069-0 2009 Relationship between serum parathyroid hormone and trace elements (serum zinc and magnesium) in hemodialyzed chronic renal failure children. Magnesium 82-91 parathyroid hormone Homo sapiens 27-46 18972069-9 2009 There was a significant negative correlation between serum levels of PTH and zinc as well as an insignificant negative correlation between PTH and serum magnesium in CRF patients. Magnesium 153-162 parathyroid hormone Homo sapiens 139-142 18972069-11 2009 However, this is another negative report on the relation between PTH and serum Mg in children with CRF. Magnesium 79-81 parathyroid hormone Homo sapiens 65-68 19425005-5 2009 PC bound to CRP in the presence of metal ions Ca(2+) and Mg(2+). Magnesium 57-59 C-reactive protein Homo sapiens 12-15 19675375-11 2009 Among micronutrients, high magnesium and calcium intake have been reported to decrease insulin resistance. Magnesium 27-36 insulin Homo sapiens 87-94 19389850-0 2009 HNF1B mutations associate with hypomagnesemia and renal magnesium wasting. Magnesium 56-65 HNF1 homeobox B Homo sapiens 0-5 19389850-12 2009 HNF1B regulates transcription of FXYD2, which participates in the tubular handling of Mg(2+), thus describing a role for HNF1B not only in nephrogenesis but also in the maintenance of tubular function. Magnesium 86-88 HNF1 homeobox B Homo sapiens 0-5 19389850-12 2009 HNF1B regulates transcription of FXYD2, which participates in the tubular handling of Mg(2+), thus describing a role for HNF1B not only in nephrogenesis but also in the maintenance of tubular function. Magnesium 86-88 FXYD domain containing ion transport regulator 2 Homo sapiens 33-38 19389850-12 2009 HNF1B regulates transcription of FXYD2, which participates in the tubular handling of Mg(2+), thus describing a role for HNF1B not only in nephrogenesis but also in the maintenance of tubular function. Magnesium 86-88 HNF1 homeobox B Homo sapiens 121-126 19410078-5 2009 The synthesis of Cyr61 in MG-63 was assessed by Western analysis. Magnesium 26-28 cellular communication network factor 1 Rattus norvegicus 17-22 18414844-2 2009 The homomeric P2X(7) receptor is extraordinary in that in addition to distinctive localization and biological functions it exhibits several hallmark properties, for example, the receptor is potently inhibited by divalent cations such as calcium, magnesium, zinc and copper. Magnesium 246-255 purinergic receptor P2X 7 Homo sapiens 14-29 19441271-0 2009 Magnesium supplementation significantly reduces serum S100beta concentrations in patients who have undergone coronary artery bypass surgery. Magnesium 0-9 S100 calcium binding protein B Homo sapiens 54-62 19441271-4 2009 This study aims to analyse different forms of Mg supplementation on serum S100beta concentrations in patients who have undergone CABG. Magnesium 46-48 S100 calcium binding protein B Homo sapiens 74-82 19441273-0 2009 The complex relationship between magnesium and serum parathyroid hormone: a study in patients with chronic intestinal failure. Magnesium 33-42 parathyroid hormone Homo sapiens 53-72 19304936-6 2009 In vitro, Arabidopsis PPH specifically dephytylates the Mg-free chlorophyll pigment, pheophytin (phein), yielding pheophorbide. Magnesium 56-58 thylakoid-associated phosphatase 38 Arabidopsis thaliana 22-25 19095394-0 2009 Magnesium effect on testosterone-SHBG association studied by a novel molecular chromatography approach. Magnesium 0-9 sex hormone binding globulin Homo sapiens 33-37 19095394-1 2009 A biochromatographic approach is developed to measure for the first time thermodynamic data and magnesium (Mg(2+)) effect for the binding of testosterone (TT) to sex hormone-binding globulin (SHBG) in a wide temperature range. Magnesium 96-105 sex hormone binding globulin Homo sapiens 162-190 19095394-1 2009 A biochromatographic approach is developed to measure for the first time thermodynamic data and magnesium (Mg(2+)) effect for the binding of testosterone (TT) to sex hormone-binding globulin (SHBG) in a wide temperature range. Magnesium 96-105 sex hormone binding globulin Homo sapiens 192-196 19095394-6 2009 At all the magnesium concentrations studied, the DeltaH values were negative due to van der Waals interactions and hydrogen bonding which are engaged at the complex interface confirming strong TT-SHBG hydrogen bond networks. Magnesium 11-20 sex hormone binding globulin Homo sapiens 196-200 19154422-7 2009 Voltage-dependent Mg(2+) block of NR2A(WT)- and NR2A(trunC)-containing NMDARs was similar but low concentrations of Mg(2+) (1 micromol.L(-1)) potentiated NR1/NR2A(delC) NMDARs. Magnesium 18-20 glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog Xenopus laevis 34-38 19187564-3 2009 Although it is well known that the synthesis and secretion of PTH is regulated by serum levels of calcium, phosphate, magnesium and 25(OH)D, less is known about the possible clustered affiliation of these parameters with MS. We aimed to explore whether MS is associated with abnormal serum levels of PTH, 25(OH)D and magnesium in a population of morbidly obese patients. Magnesium 118-127 parathyroid hormone Homo sapiens 62-65 19187564-8 2009 Patients with PTH levels in the second to fourth quartiles had higher odds of prevalent MS (odds ratio 1.47 [95% CI 0.92-2.35], 2.33 [95% CI 1.40-3.87] and 2.09 [95% CI 1.23-3.56], respectively), after adjustment for 25(OH)D, magnesium, calcium, phosphate, creatinine, age, gender, season of serum sampling, BMI, current smoking, albuminuria, CRP, insulin resistance and type 2 diabetes. Magnesium 226-235 parathyroid hormone Homo sapiens 14-17 19154422-7 2009 Voltage-dependent Mg(2+) block of NR2A(WT)- and NR2A(trunC)-containing NMDARs was similar but low concentrations of Mg(2+) (1 micromol.L(-1)) potentiated NR1/NR2A(delC) NMDARs. Magnesium 18-20 glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog Xenopus laevis 48-52 19154422-7 2009 Voltage-dependent Mg(2+) block of NR2A(WT)- and NR2A(trunC)-containing NMDARs was similar but low concentrations of Mg(2+) (1 micromol.L(-1)) potentiated NR1/NR2A(delC) NMDARs. Magnesium 18-20 glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog Xenopus laevis 48-52 19124169-0 2009 Serum and intracellular magnesium deficiency in patients with metabolic syndrome--evidences for its relation to insulin resistance. Magnesium 24-33 insulin Homo sapiens 112-119 19124169-10 2009 In conclusion, magnesium depletion in serum and mononuclear cells is common in obese people with metabolic syndrome, and it is more evident in non-white people with insulin resistance. Magnesium 15-24 insulin Homo sapiens 165-172 19103997-2 2009 The novel magnesium transporter TRPM7 is a critical regulator of magnesium homeostasis in vascular cells, but its role in pathophysiology is unclear. Magnesium 10-19 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 32-37 19170751-0 2009 Sodium/bicarbonate cotransporter NBCn1/slc4a7 increases cytotoxicity in magnesium depletion in primary cultures of hippocampal neurons. Magnesium 72-81 solute carrier family 4 member 7 Rattus norvegicus 33-38 19170751-0 2009 Sodium/bicarbonate cotransporter NBCn1/slc4a7 increases cytotoxicity in magnesium depletion in primary cultures of hippocampal neurons. Magnesium 72-81 solute carrier family 4 member 7 Rattus norvegicus 39-45 18286623-7 2009 In m-SBF with and without albumin we found an amorphous layer of carbonated calcium phosphate with some calcium replaced by magnesium. Magnesium 124-133 zinc finger protein 143 Homo sapiens 5-8 19095620-1 2009 Ribonuclease P (RNase P) is a ribonucleoprotein that catalyzes the 5" maturation of precursor transfer RNA in the presence of magnesium ions. Magnesium 126-135 ribonuclease P Saccharomyces cerevisiae S288C 0-14 19095620-1 2009 Ribonuclease P (RNase P) is a ribonucleoprotein that catalyzes the 5" maturation of precursor transfer RNA in the presence of magnesium ions. Magnesium 126-135 ribonuclease P Saccharomyces cerevisiae S288C 16-23 19149903-1 2009 BACKGROUND: Ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7) play a central role in magnesium homeostasis, which is critical for maintaining glucose and insulin metabolism. Magnesium 122-131 transient receptor potential cation channel subfamily M member 6 Homo sapiens 82-87 19149903-1 2009 BACKGROUND: Ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7) play a central role in magnesium homeostasis, which is critical for maintaining glucose and insulin metabolism. Magnesium 122-131 transient receptor potential cation channel subfamily M member 7 Homo sapiens 92-97 19149903-8 2009 Our haplotype analyses suggested a significant risk of type 2 diabetes among carriers of both the rare alleles from two non-synomous SNPs in TRPM6 (Val1393Ile in exon 26 [rs3750425] and Lys1584Glu in exon 27 [rs2274924]) when their magnesium intake was lower than 250 mg per day. Magnesium 232-241 transient receptor potential cation channel subfamily M member 6 Homo sapiens 141-146 19149903-10 2009 CONCLUSION: Our results provide suggestive evidence that two common non-synonymous TRPM6 coding region variants, Ile1393Val and Lys1584Glu polymorphisms, might confer susceptibility to type 2 diabetes in women with low magnesium intake. Magnesium 219-228 transient receptor potential cation channel subfamily M member 6 Homo sapiens 83-88 19272175-0 2009 Mutagenesis identifies the critical amino acid residues of human endonuclease G involved in catalysis, magnesium coordination, and substrate specificity. Magnesium 103-112 endonuclease G Homo sapiens 65-79 19123102-5 2009 Ca, Mg, Na, K and SO(4) were significantly leached into solution under the two leaching conditions with the total amounts in ANC leachates higher than that of DIN-S4. Magnesium 4-6 Axin Drosophila melanogaster 159-162 18812186-4 2009 GCLC catalyzes a unique gamma-carboxyl linkage from glutamate to cysteine and requires ATP and Mg(++) as cofactors in this reaction. Magnesium 95-101 glutamate-cysteine ligase catalytic subunit Homo sapiens 0-4 19013213-9 2009 The activity of another ecto-peptidase, aminopeptidase N, was also down regulated by a magnesium blockade, not regulated by NMDA receptor blockade and increased by LTCC blockade. Magnesium 87-96 alanyl aminopeptidase, membrane Rattus norvegicus 40-56 19027753-0 2009 Immunosuppressant FK506 decreases the intracellular magnesium in the human osteoblast cell by inhibiting the ERK1/2 pathway. Magnesium 52-61 mitogen-activated protein kinase 3 Homo sapiens 109-115 19027753-10 2009 SIGNIFICANCE: This study examined the role of ERK1/2 activation on the regulation of magnesium in HOB. Magnesium 85-94 mitogen-activated protein kinase 3 Homo sapiens 46-52 19027753-11 2009 These results suggest that the inhibition of ERK phosphorylation is an essential intermediate in the effects of FK506 on magnesium. Magnesium 121-130 mitogen-activated protein kinase 1 Homo sapiens 45-48 19930736-3 2009 It has been hypothesized that proton pump inhibitors impair the active transcellular magnesium transport. Magnesium 85-94 ATPase H+/K+ transporting subunit alpha Homo sapiens 30-41 19121098-10 2009 Our results indicate that the activatory effect of the Al(III)NTA complex is because of specific binding of aluminium to the polypeptide chain of GS2, however presence of magnesium at least on one of the metal-binding sites is essential to the active state of the enzyme. Magnesium 171-180 glutamine synthetase leaf isozyme, chloroplastic Triticum aestivum 146-149 19508229-8 2009 Together with previous findings that EF-hand mutants of KChIP proteins are unable to regulate the kinetics of Kv4.2, our data show that the intact EF-hands should be crucial for the formation of active conformation of KChIP2.2 when the protein is loaded with Ca(2+) and Mg(2+). Magnesium 270-272 potassium voltage-gated channel interacting protein 2 Homo sapiens 218-224 18845157-1 2008 AphA is a magnesium-dependent, bacterial class B acid phosphatase that catalyzes the hydrolysis of a variety of phosphoester substrates and belongs to the DDDD superfamily of phosphohydrolases. Magnesium 10-19 aminoglycoside 3'-phosphotransferase Escherichia coli 0-4 19056988-3 2008 Enhancing endogenous NMDAR activation in brain slices by removing external magnesium ions (Mg2+) triggered epileptiform activity, which had decreased spike amplitude and prolonged interburst interval during application of the Px1 hemichannel blocking peptide. Magnesium 75-84 pannexin 1 Homo sapiens 226-229 24459527-6 2008 The passive paracellular transport of magnesium in the TAL is closely related with the mutations in claudin-16/paracellin-1 and is responsible for familial hypomagnesemia with hypercalciuria and nephrocalcinosis. Magnesium 38-47 claudin 16 Homo sapiens 100-110 24459527-6 2008 The passive paracellular transport of magnesium in the TAL is closely related with the mutations in claudin-16/paracellin-1 and is responsible for familial hypomagnesemia with hypercalciuria and nephrocalcinosis. Magnesium 38-47 claudin 16 Homo sapiens 111-123 24459527-7 2008 The active transcellular transport of magnesium in the DCT was similarly enhanced by the realization that defects in transient receptor potential melastatin 6 (TRPM6) cause hypomagnesemia with secondary hypocalcemia. Magnesium 38-47 transient receptor potential cation channel subfamily M member 6 Homo sapiens 117-158 24459527-7 2008 The active transcellular transport of magnesium in the DCT was similarly enhanced by the realization that defects in transient receptor potential melastatin 6 (TRPM6) cause hypomagnesemia with secondary hypocalcemia. Magnesium 38-47 transient receptor potential cation channel subfamily M member 6 Homo sapiens 160-165 19016854-0 2008 Effect of magnesium ions on the activity of the cytosolic NADH/cytochrome c electron transport system. Magnesium 10-19 cytochrome c, somatic Homo sapiens 63-75 19016854-2 2008 The data presented in this article show that the protective effect of magnesium ions on the permeability of the mitochondrial outer membrane, supported by previously published data, correlates with the finding that, in hypotonic but not isotonic medium, magnesium promotes a differential effect on both the additional release of endogenous cyto-c and on the increased rate of NADH oxidation, depending on whether it is added before or after the mitochondria. Magnesium 70-79 cytochrome c, somatic Homo sapiens 340-346 19016854-2 2008 The data presented in this article show that the protective effect of magnesium ions on the permeability of the mitochondrial outer membrane, supported by previously published data, correlates with the finding that, in hypotonic but not isotonic medium, magnesium promotes a differential effect on both the additional release of endogenous cyto-c and on the increased rate of NADH oxidation, depending on whether it is added before or after the mitochondria. Magnesium 254-263 cytochrome c, somatic Homo sapiens 340-346 19016854-3 2008 At the same time, magnesium prevents or almost completely removes the binding of exogenously added cyto-c. Magnesium 18-27 cytochrome c, somatic Homo sapiens 99-105 19016854-4 2008 We suggest that, in physiological low-amplitude swelling, magnesium ions may have the function, together with other factors, of modulating the amount of cyto-c molecules transferred from the mitochondrial intermembrane space into the cytosol, required for the correct execution of the apoptotic programme and/or the activation of the NADH/cyto-c electron transport pathway. Magnesium 58-67 cytochrome c, somatic Homo sapiens 153-159 19016854-4 2008 We suggest that, in physiological low-amplitude swelling, magnesium ions may have the function, together with other factors, of modulating the amount of cyto-c molecules transferred from the mitochondrial intermembrane space into the cytosol, required for the correct execution of the apoptotic programme and/or the activation of the NADH/cyto-c electron transport pathway. Magnesium 58-67 cytochrome c, somatic Homo sapiens 339-345 19271422-4 2008 Clinical symptoms of acute phase response were observed in Mg-deficient rats and were accompanied by a reduction in plasma retinol and of plasma retinol binding protein (RBP). Magnesium 59-61 retinol binding protein 4 Rattus norvegicus 138-168 19271422-4 2008 Clinical symptoms of acute phase response were observed in Mg-deficient rats and were accompanied by a reduction in plasma retinol and of plasma retinol binding protein (RBP). Magnesium 59-61 retinol binding protein 4 Rattus norvegicus 170-173 19568996-8 2008 The mutation was present in a critical region of the COX1 gene, the V374M change being close to the two histidine residues His376 and His378 co-ordinating with the heme a and a (3), and His367 which co-ordinates a magnesium ion. Magnesium 214-223 mitochondrially encoded cytochrome c oxidase I Homo sapiens 53-57 18835339-8 2008 Our results showed that MG-132 significantly induced HO-1 mRNA in a concentration-dependent manner. Magnesium 24-26 heme oxygenase 1 Mus musculus 53-57 18794299-4 2008 Here, we used microarray analysis to show that reduced extracellular magnesium concentration increases HIP14L mRNA suggesting a role in cellular magnesium metabolism. Magnesium 69-78 zinc finger DHHC-type containing 13 L homeolog Xenopus laevis 103-109 18794299-4 2008 Here, we used microarray analysis to show that reduced extracellular magnesium concentration increases HIP14L mRNA suggesting a role in cellular magnesium metabolism. Magnesium 145-154 zinc finger DHHC-type containing 13 L homeolog Xenopus laevis 103-109 18794299-5 2008 Because HIP14 was not on the microarray platform, we used real-time reverse transcriptase-PCR to show that HIP14 and HIP14L transcripts were up-regulated 3-fold with low magnesium. Magnesium 170-179 zinc finger DHHC-type containing 13 L homeolog Xenopus laevis 117-123 18794299-8 2008 Diminished magnesium leads to an apparent increase in HIP14-green fluorescent protein and HIP14L-green fluorescent fusion proteins in the Golgi complex and subplasma membrane post-Golgi vesicles of transfected epithelial cells. Magnesium 11-20 zinc finger DHHC-type containing 13 L homeolog Xenopus laevis 90-96 18989578-0 2008 Thermodynamic study of the binding of calcium and magnesium ions with myelin basic protein using the extended solvation theory. Magnesium 50-59 myelin basic protein Bos taurus 70-90 19169055-12 2008 Serum PTH levels were positively correlated with body mass index (r=0.33 and p=0.006) and serum magnesium levels (r=0.33 and p=0.02) and negatively correlated with serum 25(OH)D levels (r=-0.33 and p=0.008), estimated calcium intake (r=-0.25 and p=0.04), and fractional excretion of calcium (r=-0.34 and p=0.009). Magnesium 96-105 parathyroid hormone Homo sapiens 6-9 18820073-7 2008 Growing P. aeruginosa PAO1 wbpL in magnesium-deficient medium (PAO1 wbpL - Mg(2+)) resulted in an increase in its zeta potential in the pH range from 3.0 to 6.5. Magnesium 35-44 glycosyltransferase WbpL Pseudomonas aeruginosa PAO1 27-31 18820073-7 2008 Growing P. aeruginosa PAO1 wbpL in magnesium-deficient medium (PAO1 wbpL - Mg(2+)) resulted in an increase in its zeta potential in the pH range from 3.0 to 6.5. Magnesium 35-44 glycosyltransferase WbpL Pseudomonas aeruginosa PAO1 68-72 18834094-3 2008 The one-electron reduction potential ( E red) of the PDI moiety in the presence of a metal ion is shifted to a positive direction due to the binding of Mg (2+) to PDI (*-), whereas the one-electron oxidation potential of the ZnPc moiety remains the same. Magnesium 152-154 peptidyl arginine deiminase 1 Homo sapiens 53-56 19197532-9 2008 RESULTS: In cases with SG and MoG there was predominance of abnormal histophysiological findings: medial layer disorganization and hyperplasic changes, with a statistically significant difference when compared to MG and CG. Magnesium 213-215 myelin oligodendrocyte glycoprotein Homo sapiens 30-33 18834094-3 2008 The one-electron reduction potential ( E red) of the PDI moiety in the presence of a metal ion is shifted to a positive direction due to the binding of Mg (2+) to PDI (*-), whereas the one-electron oxidation potential of the ZnPc moiety remains the same. Magnesium 152-154 peptidyl arginine deiminase 1 Homo sapiens 163-166 18834094-4 2008 The binding of Mg (2+) to PDI (*-) was confirmed by the ESR spectrum, which is different from that of PDI (*-) without Mg (2+). Magnesium 15-17 peptidyl arginine deiminase 1 Homo sapiens 26-29 18834094-4 2008 The binding of Mg (2+) to PDI (*-) was confirmed by the ESR spectrum, which is different from that of PDI (*-) without Mg (2+). Magnesium 15-17 peptidyl arginine deiminase 1 Homo sapiens 102-105 18845707-7 2008 RESULTS: Relative to non-consumers, bean consumers had higher intakes of dietary fiber, potassium, magnesium, iron, and copper (p"s < 0.05). Magnesium 99-108 brain expressed associated with NEDD4 1 Homo sapiens 36-40 18706480-6 2008 We found a significant increase in synaptosomal membrane GluR1 expression in magnesium-free (MGF) medium-treated neurons at each time point detected (p<0.05), while GluR2 expression increased at 7DIV, and declined at 17DIV and 21DIV respectively (p<0.05). Magnesium 77-86 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 57-62 18667602-8 2008 With the use of immunofluorescence, it was shown that NIPA2 protein was normally localized to the early endosomes and plasma membrane and was recruited to the plasma membrane in response to low extracellular magnesium. Magnesium 208-217 NIPA magnesium transporter 2 L homeolog Xenopus laevis 54-59 18667602-9 2008 We conclude that NIPA2 plays a role in magnesium metabolism and regulation of renal magnesium conservation. Magnesium 39-48 NIPA magnesium transporter 2 L homeolog Xenopus laevis 17-22 18667602-9 2008 We conclude that NIPA2 plays a role in magnesium metabolism and regulation of renal magnesium conservation. Magnesium 84-93 NIPA magnesium transporter 2 L homeolog Xenopus laevis 17-22 19083473-6 2008 Also, there is an inverse relationship between serum magnesium levels and high-sensitivity C-reactive protein. Magnesium 53-62 C-reactive protein Homo sapiens 91-109 18725455-6 2008 The structure of BC bound to AMPPNP and the two catalytically essential magnesium ions resolves inconsistencies between the kinetics of active-site BC mutants and previously reported BC structures. Magnesium 72-81 methylcrotonyl-CoA carboxylase subunit 2 Homo sapiens 17-19 18725455-6 2008 The structure of BC bound to AMPPNP and the two catalytically essential magnesium ions resolves inconsistencies between the kinetics of active-site BC mutants and previously reported BC structures. Magnesium 72-81 methylcrotonyl-CoA carboxylase subunit 2 Homo sapiens 148-150 18725455-6 2008 The structure of BC bound to AMPPNP and the two catalytically essential magnesium ions resolves inconsistencies between the kinetics of active-site BC mutants and previously reported BC structures. Magnesium 72-81 methylcrotonyl-CoA carboxylase subunit 2 Homo sapiens 148-150 18720966-6 2008 The MP2 results correlate well with the available experimental data and theoretical findings indicating that Lys72, Asp166, and the two magnesium ions contribute -22.7, -13.3, -32.4, and -15.2 kcal/mol to differential transition state stabilization, respectively. Magnesium 136-145 tryptase pseudogene 1 Homo sapiens 4-7 18652879-13 2008 The present work provides the first detailed quantitative description of the elementary properties of the Kir inward rectifier in pigeon vestibular type II hair cells and specifically describes the Kir gating properties and the molecule"s sensitivity to extracellular Mg(2+) for all subconductance levels. Magnesium 268-270 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 106-109 18442037-1 2008 Claudin-16 (Paracellin-1) is a transmembrane tight junction (TJ) protein originally described as having a critical role in the re-absorption of magnesium and calcium in the kidney. Magnesium 144-153 claudin 16 Homo sapiens 12-24 18663477-7 2008 Although daily urinary excretion of Mg(++), and to a lesser extent of Ca(++), tends to be higher in claudin 11/claudin 14 double mutants, these changes do not reach statistical significance compared with wild-type animals. Magnesium 36-42 claudin 11 Mus musculus 100-110 18663477-7 2008 Although daily urinary excretion of Mg(++), and to a lesser extent of Ca(++), tends to be higher in claudin 11/claudin 14 double mutants, these changes do not reach statistical significance compared with wild-type animals. Magnesium 36-42 claudin 14 Mus musculus 111-121 18442037-1 2008 Claudin-16 (Paracellin-1) is a transmembrane tight junction (TJ) protein originally described as having a critical role in the re-absorption of magnesium and calcium in the kidney. Magnesium 144-153 claudin 16 Homo sapiens 0-10 18492754-9 2008 Repeated serum measures over a 24-h period showed that twice-daily PTH 1-34 increased serum calcium and magnesium levels more effectively than a once-daily dose. Magnesium 104-113 parathyroid hormone Homo sapiens 67-72 19009820-0 2008 Magnesium and its relationship to C-reactive protein among hemodialysis patients. Magnesium 0-9 C-reactive protein Homo sapiens 34-52 19009820-2 2008 Recently, a possible correlation between serum magnesium (Mg) and C-reactive protein (CRP) has been stressed. Magnesium 47-56 C-reactive protein Homo sapiens 66-84 19009822-5 2008 Low magnesium also enhanced 6-keto-PGF1alpha production, activated PLA2 and COX, enhanced (45)Ca2+ influx and decreased the remaining arachidonic acid in phospholipids. Magnesium 4-13 phospholipase A2 group IB Homo sapiens 67-71 19009820-2 2008 Recently, a possible correlation between serum magnesium (Mg) and C-reactive protein (CRP) has been stressed. Magnesium 47-56 C-reactive protein Homo sapiens 86-89 19009820-4 2008 In this study we aimed to determine the relationship between serum Mg and hs-CRP levels in patients undergoing HD. Magnesium 67-69 C-reactive protein Homo sapiens 77-80 19009820-11 2008 There was a significant negative correlation between serum Mg and serum hs-CRP (p < 0.04). Magnesium 59-61 C-reactive protein Homo sapiens 75-78 19009821-2 2008 MGH and MGL mice, selected for high and low Mg status, are animal models which present variations of Mg metabolism of genetic origin. Magnesium 44-46 C-type lectin domain family 10, member A Mus musculus 8-11 19009821-2 2008 MGH and MGL mice, selected for high and low Mg status, are animal models which present variations of Mg metabolism of genetic origin. Magnesium 101-103 C-type lectin domain family 10, member A Mus musculus 8-11 19066406-8 2008 The antidepressant mechanisms of zinc and magnesium are discussed in the context of glutamate, brain-derived neurotrophic factor (BDNF) and glycogen synthase kinase-3 (GSK-3) hypotheses. Magnesium 42-51 brain-derived neurotrophic factor Rattus norvegicus 130-134 18661979-3 2008 A magnesium-based material is presented that is the highest surface area magnesium MCP yet reported and displays ultrahigh affinity based on heat of adsorption for CO2. Magnesium 2-11 CD46 molecule Homo sapiens 83-86 18642932-3 2008 At room temperature, DNA gyrase structure is not appreciably affected by Ca (2+) or Mg (2+) but is modified by Mn (2+). Magnesium 84-86 DNA topoisomerase II alpha Homo sapiens 21-31 18661979-3 2008 A magnesium-based material is presented that is the highest surface area magnesium MCP yet reported and displays ultrahigh affinity based on heat of adsorption for CO2. Magnesium 73-82 CD46 molecule Homo sapiens 83-86 18593862-8 2008 Comparison of the sequence of Tas1r3 with calcium and saccharin preferences in inbred mouse strains found 1) an inverse correlation between calcium and saccharin preference scores across primarily domesticus strains, which was associated with an I60T substitution in T1R3, and 2) a V689A substitution in T1R3 that was unique to the PWK strain and thus may be responsible for its strong calcium and magnesium preference. Magnesium 398-407 taste receptor, type 1, member 3 Mus musculus 267-271 17641003-1 2008 OBJECTIVE: To assess the hypothesis that magnesium deficiency is associated with elevated high-sensitivity C-reactive protein (hsCRP) levels. Magnesium 41-50 C-reactive protein Homo sapiens 107-125 18448585-8 2008 Calcium uptake by TRPV5 was directly inhibited by magnesium and low pH. Magnesium 50-59 transient receptor potential cation channel, subfamily V, member 5 Rattus norvegicus 18-23 18562569-2 2008 The discovery that mutations in claudin-16/paracellin-1 or claudin-19 are responsible for familial hypomagnesemia with hypercalciuria and nephrocalcinosis provided insight into the molecular mechanisms governing paracellular transport of Mg(2+). Magnesium 238-240 claudin 16 Homo sapiens 32-42 18562569-2 2008 The discovery that mutations in claudin-16/paracellin-1 or claudin-19 are responsible for familial hypomagnesemia with hypercalciuria and nephrocalcinosis provided insight into the molecular mechanisms governing paracellular transport of Mg(2+). Magnesium 238-240 claudin 16 Homo sapiens 43-55 18562569-2 2008 The discovery that mutations in claudin-16/paracellin-1 or claudin-19 are responsible for familial hypomagnesemia with hypercalciuria and nephrocalcinosis provided insight into the molecular mechanisms governing paracellular transport of Mg(2+). Magnesium 238-240 claudin 19 Homo sapiens 59-69 18562569-10 2008 We anticipate that the next decade will provide further detail into the control of the gatekeeper TRPM6 and, therefore, overall whole-body Mg(2+) balance. Magnesium 139-141 transient receptor potential cation channel subfamily M member 6 Homo sapiens 98-103 18396151-4 2008 Binding of NS1-2 peptide derived from the RNA binding site of NS1 protein, to U6-34 was inhibited by spermidine but not by Mg(2+). Magnesium 123-125 influenza virus NS1A binding protein Homo sapiens 62-65 18593862-0 2008 Involvement of T1R3 in calcium-magnesium taste. Magnesium 31-40 taste receptor, type 1, member 3 Mus musculus 15-19 18593862-4 2008 A genome scan of B6 x PWK F2 mice linked a component of the strain difference in calcium and magnesium preference to distal chromosome 4. Magnesium 93-102 patchwork Mus musculus 22-25 18593862-6 2008 Most notably, calcium and magnesium solutions that were avoided by wild-type B6 mice were preferred (relative to water) by B6 mice null for the Tas1r3 gene. Magnesium 26-35 taste receptor, type 1, member 3 Mus musculus 144-150 18593862-8 2008 Comparison of the sequence of Tas1r3 with calcium and saccharin preferences in inbred mouse strains found 1) an inverse correlation between calcium and saccharin preference scores across primarily domesticus strains, which was associated with an I60T substitution in T1R3, and 2) a V689A substitution in T1R3 that was unique to the PWK strain and thus may be responsible for its strong calcium and magnesium preference. Magnesium 398-407 taste receptor, type 1, member 3 Mus musculus 30-36 18448590-9 2008 These results suggest that FXYD2 can mediate basolateral extrusion of magnesium from cultured renal epithelial cells and provide new insights into the understanding of the possible physiological roles of FXYD2 wild-type and mutant proteins. Magnesium 70-79 FXYD domain containing ion transport regulator 2 Canis lupus familiaris 27-32 18590694-1 2008 Lymphocytes lacking the TRPM7 (transient receptor potential cation channel, subfamily M, member 7) dual function ion channel/protein kinase exhibit a unique phenotype: they are unable to proliferate in regular media, but proliferate normally in media supplemented with 10-15 mM extracellular Mg(2+). Magnesium 292-294 transient receptor potential cation channel subfamily M member 7 Homo sapiens 24-29 18590694-1 2008 Lymphocytes lacking the TRPM7 (transient receptor potential cation channel, subfamily M, member 7) dual function ion channel/protein kinase exhibit a unique phenotype: they are unable to proliferate in regular media, but proliferate normally in media supplemented with 10-15 mM extracellular Mg(2+). Magnesium 292-294 transient receptor potential cation channel subfamily M member 7 Homo sapiens 31-97 18614418-0 2008 The effect of magnesium supplementation on glucose and insulin levels of tae-kwan-do sportsmen and sedentary subjects. Magnesium 14-23 insulin Homo sapiens 55-62 18614418-1 2008 This study was performed to determine how the magnesium supplementation for a 4-week period affects the glucose and insulin levels at rest and at exhaustion in sportsmen. Magnesium 46-55 insulin Homo sapiens 116-123 18587047-5 2008 Binding is mediated by the I domain metal ion-dependent adhesion site motif, requires Mg(2+) or Mn(2+), is abolished with EDTA, and an NSP4 point mutant, E(120)A, fails to bind alpha2 integrin I domain. Magnesium 86-88 protease, serine 57 Mus musculus 135-139 18435911-6 2008 In this connection, MG-132 activated BMP signaling, manifested as an increase in Smad1/5/8 phosphorylation and up-regulation of p21(Waf1/Cip1) mRNA and protein expression. Magnesium 20-22 bone morphogenetic protein 1 Homo sapiens 37-40 18435911-6 2008 In this connection, MG-132 activated BMP signaling, manifested as an increase in Smad1/5/8 phosphorylation and up-regulation of p21(Waf1/Cip1) mRNA and protein expression. Magnesium 20-22 SMAD family member 1 Homo sapiens 81-88 18435911-6 2008 In this connection, MG-132 activated BMP signaling, manifested as an increase in Smad1/5/8 phosphorylation and up-regulation of p21(Waf1/Cip1) mRNA and protein expression. Magnesium 20-22 cyclin dependent kinase inhibitor 1A Homo sapiens 128-131 18435911-6 2008 In this connection, MG-132 activated BMP signaling, manifested as an increase in Smad1/5/8 phosphorylation and up-regulation of p21(Waf1/Cip1) mRNA and protein expression. Magnesium 20-22 cyclin dependent kinase inhibitor 1A Homo sapiens 132-136 18435911-6 2008 In this connection, MG-132 activated BMP signaling, manifested as an increase in Smad1/5/8 phosphorylation and up-regulation of p21(Waf1/Cip1) mRNA and protein expression. Magnesium 20-22 cyclin dependent kinase inhibitor 1A Homo sapiens 137-141 18495115-6 2008 Serial deletion constructs revealed two regions responsible for the magnesium ion-mediated activation, one between bps -404 and -190, and the other between bps -190 and -82. siRNA for the cAMP response element-binding protein (CREB) sequence located between bp -404 and -190 counteracted the magnesium ion-mediated activation of aquaporin 3 transcription. Magnesium 68-77 cAMP responsive element binding protein 1 Homo sapiens 188-225 18495115-6 2008 Serial deletion constructs revealed two regions responsible for the magnesium ion-mediated activation, one between bps -404 and -190, and the other between bps -190 and -82. siRNA for the cAMP response element-binding protein (CREB) sequence located between bp -404 and -190 counteracted the magnesium ion-mediated activation of aquaporin 3 transcription. Magnesium 68-77 cAMP responsive element binding protein 1 Homo sapiens 227-231 18495115-6 2008 Serial deletion constructs revealed two regions responsible for the magnesium ion-mediated activation, one between bps -404 and -190, and the other between bps -190 and -82. siRNA for the cAMP response element-binding protein (CREB) sequence located between bp -404 and -190 counteracted the magnesium ion-mediated activation of aquaporin 3 transcription. Magnesium 68-77 aquaporin 3 (Gill blood group) Homo sapiens 329-340 18495115-6 2008 Serial deletion constructs revealed two regions responsible for the magnesium ion-mediated activation, one between bps -404 and -190, and the other between bps -190 and -82. siRNA for the cAMP response element-binding protein (CREB) sequence located between bp -404 and -190 counteracted the magnesium ion-mediated activation of aquaporin 3 transcription. Magnesium 292-301 cAMP responsive element binding protein 1 Homo sapiens 227-231 18495115-7 2008 These results suggest that signal transducers, adenylyl cyclase, protein kinase A (PKA), mitogen-activated protein kinase 1/2 (MEK1/2), and mitogen- and stress-activated protein kinase 1 (MSK1), were involved in the signaling pathway for regulating transcription of the aquaporin 3 gene and CREB is one of the transcriptional regulators for aquaporin 3 gene expression mediated by magnesium ion. Magnesium 381-390 mitogen-activated protein kinase 12 Homo sapiens 89-125 18495115-7 2008 These results suggest that signal transducers, adenylyl cyclase, protein kinase A (PKA), mitogen-activated protein kinase 1/2 (MEK1/2), and mitogen- and stress-activated protein kinase 1 (MSK1), were involved in the signaling pathway for regulating transcription of the aquaporin 3 gene and CREB is one of the transcriptional regulators for aquaporin 3 gene expression mediated by magnesium ion. Magnesium 381-390 ribosomal protein S6 kinase A5 Homo sapiens 140-186 18495115-7 2008 These results suggest that signal transducers, adenylyl cyclase, protein kinase A (PKA), mitogen-activated protein kinase 1/2 (MEK1/2), and mitogen- and stress-activated protein kinase 1 (MSK1), were involved in the signaling pathway for regulating transcription of the aquaporin 3 gene and CREB is one of the transcriptional regulators for aquaporin 3 gene expression mediated by magnesium ion. Magnesium 381-390 ribosomal protein S6 kinase A5 Homo sapiens 188-192 18564178-6 2008 It has been shown that serine racemase is activated by divalent cations like calcium, magnesium and manganese, as well as by nucleotides like ATP, ADP or GTP. Magnesium 86-95 serine racemase Homo sapiens 23-38 19825572-4 2008 The AtMGT5 protein is localized in the mitochondria, suggesting that AtMGT5 mediates Mg-trafficking between the cytosol and mitochondria. Magnesium 85-87 magnesium transport 5 Arabidopsis thaliana 4-10 19825572-4 2008 The AtMGT5 protein is localized in the mitochondria, suggesting that AtMGT5 mediates Mg-trafficking between the cytosol and mitochondria. Magnesium 85-87 magnesium transport 5 Arabidopsis thaliana 69-75 18367447-3 2008 Here, we demonstrate that human SLC41A1 overexpressed in HEK293 cells forms protein complexes and locates to the plasma membrane without, however, giving rise to any detectable magnesium currents during whole cell patch clamp experiments. Magnesium 177-186 solute carrier family 41 member 1 Homo sapiens 32-39 18367447-4 2008 Nevertheless, in a strain of Salmonella enterica exhibiting disruption of all three distinct magnesium transport systems (CorA, MgtA, and MgtB), overexpression of human SLC41A1 functionally substitutes these transporters and restores the growth of the mutant bacteria at magnesium concentrations otherwise non-permissive for growth. Magnesium 93-102 solute carrier family 41 member 1 Homo sapiens 169-176 18367447-4 2008 Nevertheless, in a strain of Salmonella enterica exhibiting disruption of all three distinct magnesium transport systems (CorA, MgtA, and MgtB), overexpression of human SLC41A1 functionally substitutes these transporters and restores the growth of the mutant bacteria at magnesium concentrations otherwise non-permissive for growth. Magnesium 271-280 solute carrier family 41 member 1 Homo sapiens 169-176 18367447-6 2008 Most importantly, overexpressed SLC41A1 provide HEK293 cells with an increased magnesium efflux capacity. Magnesium 79-88 solute carrier family 41 member 1 Homo sapiens 32-39 18367447-7 2008 With outwardly directed Mg(2+) gradients, a SLC41A1-dependent reduction of the free intracellular magnesium concentration accompanied by a significant net decrease of the total cellular magnesium concentration could be observed in such cells. Magnesium 98-107 solute carrier family 41 member 1 Homo sapiens 44-51 18367447-7 2008 With outwardly directed Mg(2+) gradients, a SLC41A1-dependent reduction of the free intracellular magnesium concentration accompanied by a significant net decrease of the total cellular magnesium concentration could be observed in such cells. Magnesium 186-195 solute carrier family 41 member 1 Homo sapiens 44-51 18367447-9 2008 Taken together, these data functionally identify SLC41A1 as a mammalian carrier mediating magnesium efflux. Magnesium 90-99 solute carrier family 41 member 1 Homo sapiens 49-56 18411280-4 2008 It does so via a pair of fingertip aspartates that can bind magnesium, placing TFIIB within a family of proteins that insert finger domains to alter the catalytic functions of RNA polymerase. Magnesium 60-69 cilia and flagella associated protein 20 Homo sapiens 79-84 18490814-0 2008 On the crystal chemistry of olivine-type germanate compounds, Ca1 + xM1 - xGeO4 (M2+ = Ca, Mg, Co, Mn). Magnesium 91-93 carbonic anhydrase 1 Homo sapiens 62-65 18385471-0 2008 Relationship between low magnesium status and TRPM6 expression in the kidney and large intestine. Magnesium 25-34 transient receptor potential cation channel, subfamily M, member 6 Mus musculus 46-51 18414391-9 2008 Further analysis revealed that MG-132 upregulated the expression of BMP1 and BMP2, which are secreted members of the BMP superfamily. Magnesium 31-33 bone morphogenetic protein 1 Homo sapiens 68-72 18414391-9 2008 Further analysis revealed that MG-132 upregulated the expression of BMP1 and BMP2, which are secreted members of the BMP superfamily. Magnesium 31-33 bone morphogenetic protein 2 Homo sapiens 77-81 18414391-9 2008 Further analysis revealed that MG-132 upregulated the expression of BMP1 and BMP2, which are secreted members of the BMP superfamily. Magnesium 31-33 bone morphogenetic protein 1 Homo sapiens 68-71 18473701-0 2008 Biological interaction between anti-epidermal growth factor receptor agent cetuximab and magnesium. Magnesium 89-98 epidermal growth factor receptor Homo sapiens 36-68 18473701-2 2008 Cetuximab, by the inhibition of epidermal growth factor (EGR), is able to induce hypomagnesaemia by interfering with magnesium transport in the kidney. Magnesium 117-126 epidermal growth factor Homo sapiens 32-55 18473701-2 2008 Cetuximab, by the inhibition of epidermal growth factor (EGR), is able to induce hypomagnesaemia by interfering with magnesium transport in the kidney. Magnesium 117-126 epidermal growth factor Homo sapiens 57-60 18473701-3 2008 OBJECTIVE: To investigate the interactions between magnesium homeostasis and EGF receptor (EGFR) inhibition. Magnesium 51-60 epidermal growth factor receptor Homo sapiens 77-89 18473701-6 2008 RESULTS/CONCLUSION: We propose that EGFR inhibition may reduce cancer proliferation and also decrease magnesium levels. Magnesium 102-111 epidermal growth factor receptor Homo sapiens 36-40 18473701-7 2008 These reduced magnesium levels in turn contribute to the inhibition of angiogenesis by directly acting on endothelial cells and indirectly affecting EGFR signalling and the production of angiogenic molecules. Magnesium 14-23 epidermal growth factor receptor Homo sapiens 149-153 19325796-1 2008 Photoinduced biohydrogen production systems, coupling saccharaides biomass such as sucrose, maltose, cellobiose, cellulose, or saccharides mixture hydrolysis by enzymes and glucose dehydrogenase (GDH), and hydrogen production with platinum colloid as a catalyst using the visible light-induced photosensitization of Mg chlorophyll-a (Mg Chl-a) from higher green plant or artificial chlorophyll analog, zinc porphyrin, are introduced. Magnesium 316-318 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 196-199 18705540-9 2008 In conclusion, TRPM7, MagT1 and a Na+/Mg2+ exchanger are shown to be the main Mg transport proteins in REC and their expression and functional activity is influenced by the cellular Mg status. Magnesium 38-40 transient receptor potential cation channel subfamily M member 7 Homo sapiens 15-20 18705541-5 2008 Moreover, we obtained an activation of caspase-3 and a higher lipid peroxidation in the Mg-deficient group, as compared to the Mg standard group, while no changes in Mg-supplemented group were observed, in accordance with our previously published data in primary cultures of rat hepatocytes (Martin et al., J Nutr 2003). Magnesium 88-90 caspase 3 Rattus norvegicus 39-48 18026717-0 2008 Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A. Magnesium 34-43 transient receptor potential cation channel subfamily M member 6 Canis lupus familiaris 19-24 18026717-1 2008 Transient receptor potential melastatin 6 (TRPM6) is distributed along the apical membrane of the renal tubular cells and is involved in the reabsorption of magnesium. Magnesium 157-166 transient receptor potential cation channel subfamily M member 6 Canis lupus familiaris 0-41 18026717-1 2008 Transient receptor potential melastatin 6 (TRPM6) is distributed along the apical membrane of the renal tubular cells and is involved in the reabsorption of magnesium. Magnesium 157-166 transient receptor potential cation channel subfamily M member 6 Canis lupus familiaris 43-48 18253757-3 2008 Claudin-16 belongs to the claudin family and regulates the paracellular transport of magnesium and calcium. Magnesium 85-94 claudin 16 Homo sapiens 0-10 18339311-4 2008 Furthermore, EGF enhanced the influx of magnesium, whereas U0126 and TRPM6 siRNA inhibited it. Magnesium 40-49 epidermal growth factor Rattus norvegicus 13-16 18339311-6 2008 The phosphorylation of ERK1/2 may up-regulate TRPM6 expression and magnesium influx, resulting in an increase in cell proliferation with a shift from G1 to S phase. Magnesium 67-76 mitogen activated protein kinase 3 Rattus norvegicus 23-29 18407645-1 2008 The direct coupling of a variety of amides with CH2 Cl2 or CD2 Cl2 promoted by TiCl 4/Mg/THF provides an extremely simple, practical, selective, and efficient approach for the construction of methyl ketones. Magnesium 86-88 CD2 molecule Homo sapiens 59-62 18495115-0 2008 Regulation of aquaporin 3 expression by magnesium ion. Magnesium 40-49 aquaporin 3 (Gill blood group) Homo sapiens 14-25 18348127-4 2008 Optimum reaction conditions (level of Mg(2+), buffer type, ionic strength, pH, enzyme concentration, and reaction time) were established to both maintain the activity of GSK-3beta and allow for substrate and product quantification through ESI/MS/MS. Magnesium 38-40 glycogen synthase kinase 3 beta Homo sapiens 170-179 18280258-0 2008 Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins. Magnesium 88-97 frataxin Homo sapiens 58-66 18280258-7 2008 Consistent with this hypothesis, in vitro experiments performed with pure pyruvate kinase and phosphoglycerate kinase showed that oxidation of these proteins can be prevented by magnesium and increased by the presence of ATP. Magnesium 178-187 phosphoglycerate kinase Saccharomyces cerevisiae S288C 94-117 18359815-4 2008 MsbB2 increases overall hexa-acylation of lipid A under limited magnesium conditions. Magnesium 64-73 MsbB2 Shigella flexneri 0-5 18359815-5 2008 Regulation of MsbB2 by magnesium occurs at the level of transcription and is dependent on the conserved magnesium-inducible PhoPQ two-component regulatory pathway. Magnesium 23-32 MsbB2 Shigella flexneri 14-19 18359815-5 2008 Regulation of MsbB2 by magnesium occurs at the level of transcription and is dependent on the conserved magnesium-inducible PhoPQ two-component regulatory pathway. Magnesium 104-113 MsbB2 Shigella flexneri 14-19 18261461-1 2008 The divalent cations Mg(2+), Mn(2+), Zn(2+), Ca(2+), and Ni(2+) were found to protect against proteolysis a form of GroEL (ox-GroEL) prepared by exposing GroEL for 16h to 6mM hydrogen peroxide (H(2)O(2)). Magnesium 21-23 heat shock protein family D (Hsp60) member 1 Homo sapiens 116-121 18391207-6 2008 IMR-90 fibroblast populations cultured in magnesium-deficient conditions had increased senescence-associated beta-galactosidase activity and increased p16(INK4a) and p21(WAF1) protein expression compared with cultures from standard media conditions. Magnesium 42-51 galactosidase beta 1 Homo sapiens 109-127 18391207-6 2008 IMR-90 fibroblast populations cultured in magnesium-deficient conditions had increased senescence-associated beta-galactosidase activity and increased p16(INK4a) and p21(WAF1) protein expression compared with cultures from standard media conditions. Magnesium 42-51 cyclin dependent kinase inhibitor 2A Homo sapiens 151-154 18391207-6 2008 IMR-90 fibroblast populations cultured in magnesium-deficient conditions had increased senescence-associated beta-galactosidase activity and increased p16(INK4a) and p21(WAF1) protein expression compared with cultures from standard media conditions. Magnesium 42-51 cyclin dependent kinase inhibitor 2A Homo sapiens 155-160 18391207-6 2008 IMR-90 fibroblast populations cultured in magnesium-deficient conditions had increased senescence-associated beta-galactosidase activity and increased p16(INK4a) and p21(WAF1) protein expression compared with cultures from standard media conditions. Magnesium 42-51 cyclin dependent kinase inhibitor 1A Homo sapiens 166-169 18391207-6 2008 IMR-90 fibroblast populations cultured in magnesium-deficient conditions had increased senescence-associated beta-galactosidase activity and increased p16(INK4a) and p21(WAF1) protein expression compared with cultures from standard media conditions. Magnesium 42-51 cyclin dependent kinase inhibitor 1A Homo sapiens 170-174 18261461-1 2008 The divalent cations Mg(2+), Mn(2+), Zn(2+), Ca(2+), and Ni(2+) were found to protect against proteolysis a form of GroEL (ox-GroEL) prepared by exposing GroEL for 16h to 6mM hydrogen peroxide (H(2)O(2)). Magnesium 21-23 heat shock protein family D (Hsp60) member 1 Homo sapiens 123-131 18261461-1 2008 The divalent cations Mg(2+), Mn(2+), Zn(2+), Ca(2+), and Ni(2+) were found to protect against proteolysis a form of GroEL (ox-GroEL) prepared by exposing GroEL for 16h to 6mM hydrogen peroxide (H(2)O(2)). Magnesium 21-23 heat shock protein family D (Hsp60) member 1 Homo sapiens 126-131 18230606-1 2008 The chaperonin GroEL assists protein folding in the presence of ATP and magnesium through substrate protein capsulation in combination with the cofactor GroES. Magnesium 72-81 GroEL Escherichia coli 15-20 18268139-9 2008 Magnesium attenuated renal and cardiac interleukin-6 content and decreased renal VCAM1 and cardiac COX2 expression (P<0.05). Magnesium 0-9 interleukin 6 Mus musculus 39-52 18234677-0 2008 The Saccharomyces cerevisiae PHM8 gene encodes a soluble magnesium-dependent lysophosphatidic acid phosphatase. Magnesium 57-66 bifunctional nucleotidase/lysophosphatidic acid phosphatase Saccharomyces cerevisiae S288C 29-33 18237544-2 2008 Two molecules of thermine and one Mg2+ ion were connected to DNA molecule when thermine and d(CGCGCG)2 were co-crystallized at 4 and at 20 degrees C. When an increased concentration of magnesium and thermine molecules were co-crystallized with d(CGCGCG)2 molecules at 10 degrees C, three Mg2+ ions and only one thermine molecule were bound with a d(CGCGCG)2 molecule. Magnesium 185-194 mucin 7, secreted Homo sapiens 34-37 18237544-2 2008 Two molecules of thermine and one Mg2+ ion were connected to DNA molecule when thermine and d(CGCGCG)2 were co-crystallized at 4 and at 20 degrees C. When an increased concentration of magnesium and thermine molecules were co-crystallized with d(CGCGCG)2 molecules at 10 degrees C, three Mg2+ ions and only one thermine molecule were bound with a d(CGCGCG)2 molecule. Magnesium 185-194 mucin 7, secreted Homo sapiens 288-291 18268139-9 2008 Magnesium attenuated renal and cardiac interleukin-6 content and decreased renal VCAM1 and cardiac COX2 expression (P<0.05). Magnesium 0-9 cytochrome c oxidase II, mitochondrial Mus musculus 99-103 18390781-7 2008 Dietary magnesium is also recommended to aid in the prevention of stroke and is important for skeletal growth and development. Magnesium 8-17 activation induced cytidine deaminase Homo sapiens 41-44 18339421-7 2008 Both IGF-II and Leu(27)-IGF-II increased fetal plasma amino acid concentrations and placental transfer of MG to the fetus compared to vehicle, with Leu(27)-IGF-II also increasing AIB transport compared with vehicle and IGF-II. Magnesium 106-108 insulin-like growth factor II Cavia porcellus 5-11 18339421-7 2008 Both IGF-II and Leu(27)-IGF-II increased fetal plasma amino acid concentrations and placental transfer of MG to the fetus compared to vehicle, with Leu(27)-IGF-II also increasing AIB transport compared with vehicle and IGF-II. Magnesium 106-108 insulin-like growth factor II Cavia porcellus 24-30 18339421-7 2008 Both IGF-II and Leu(27)-IGF-II increased fetal plasma amino acid concentrations and placental transfer of MG to the fetus compared to vehicle, with Leu(27)-IGF-II also increasing AIB transport compared with vehicle and IGF-II. Magnesium 106-108 insulin-like growth factor II Cavia porcellus 24-30 18339421-7 2008 Both IGF-II and Leu(27)-IGF-II increased fetal plasma amino acid concentrations and placental transfer of MG to the fetus compared to vehicle, with Leu(27)-IGF-II also increasing AIB transport compared with vehicle and IGF-II. Magnesium 106-108 insulin-like growth factor II Cavia porcellus 24-30 18179772-3 2008 This study demonstrates the binding of purified C1q to recombinant adiponectin under physiological conditions, and the dependence of this upon Ca(++) and Mg(++). Magnesium 154-160 complement C1q A chain Homo sapiens 48-51 18314503-1 2008 Substrate recognition by the VS ribozyme involves a magnesium-dependent loop/loop interaction between the SLI substrate and the SLV hairpin from the catalytic domain. Magnesium 52-61 SHC adaptor protein 2 Homo sapiens 106-109 18314503-1 2008 Substrate recognition by the VS ribozyme involves a magnesium-dependent loop/loop interaction between the SLI substrate and the SLV hairpin from the catalytic domain. Magnesium 52-61 solute carrier family 50 member 1 Homo sapiens 128-131 18314503-2 2008 Recent NMR studies of SLV demonstrated that magnesium ions stabilize a U-turn loop structure and trigger a conformational change for the extruded loop residue U700, suggesting a role for U700 in SLI recognition. Magnesium 44-53 solute carrier family 50 member 1 Homo sapiens 22-25 18314503-2 2008 Recent NMR studies of SLV demonstrated that magnesium ions stabilize a U-turn loop structure and trigger a conformational change for the extruded loop residue U700, suggesting a role for U700 in SLI recognition. Magnesium 44-53 SHC adaptor protein 2 Homo sapiens 195-198 18192217-9 2008 This review discusses the importance of magnesium in vascular biology and implications in hypertension and highlights the transport systems, particularly TRPM6 and TRPM7, which may play a role in the control of vascular magnesium homeostasis. Magnesium 220-229 transient receptor potential cation channel subfamily M member 6 Homo sapiens 154-159 18192217-9 2008 This review discusses the importance of magnesium in vascular biology and implications in hypertension and highlights the transport systems, particularly TRPM6 and TRPM7, which may play a role in the control of vascular magnesium homeostasis. Magnesium 220-229 transient receptor potential cation channel subfamily M member 7 Homo sapiens 164-169 17999037-1 2008 The effects of a 1-month exercise program and magnesium supplementation on the adrenocorticotropic hormone and cortisol levels were studied in young tae-kwon-do and sedentary subjects both at rest and exhaustion. Magnesium 46-55 proopiomelanocortin Homo sapiens 79-106 17999037-3 2008 Both exercise and magnesium supplements caused significant increases of the adrenocorticotropic hormone (p < 0.05). Magnesium 18-27 proopiomelanocortin Homo sapiens 76-103 17999037-6 2008 The results of this study show that exercise and/or magnesium supplementation causes a rise of the adrenocorticotropic hormone, whereas cortisol is increased only as a result of combined exhaustion and magnesium supplements. Magnesium 52-61 proopiomelanocortin Homo sapiens 99-126 18274977-2 2008 Some research has indicated that lower intakes of magnesium and lower serum magnesium concentrations may lead to and are associated with the metabolic syndrome, insulin resistance, and/or type 2 diabetes mellitus. Magnesium 50-59 insulin Homo sapiens 161-168 18274977-2 2008 Some research has indicated that lower intakes of magnesium and lower serum magnesium concentrations may lead to and are associated with the metabolic syndrome, insulin resistance, and/or type 2 diabetes mellitus. Magnesium 76-85 insulin Homo sapiens 161-168 18301276-5 2008 Recent studies have shown that TRPM7 channel activity is regulated by intracellular Mg and magnesium-nucleotides and modulated via this phosphotransferase kinase. Magnesium 84-86 transient receptor potential cation channel subfamily M member 7 Homo sapiens 31-36 17989916-1 2008 Deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase (dNTPase) from Thermus thermophilus HB8 (TTHB8) hydrolyzes wide variety of dNTPs to deoxyribonucleoside and inorganic triphosphate in magnesium-dependent manner. Magnesium 194-203 NTPase Drosophila melanogaster 61-68 17989916-6 2008 Though cobalt ion was below detectable level, magnesium and manganese ions were detected at sufficient level to induce dNTPase activity. Magnesium 46-55 NTPase Drosophila melanogaster 119-126 17989916-8 2008 In addition, the proposed model of dNTPase activity induced by magnesium and multiple dNTPs was discussed based on the results obtained in this study. Magnesium 63-72 NTPase Drosophila melanogaster 35-42 18248433-0 2008 Regulation of magnesium homeostasis in Salmonella: Mg(2+) targets the mgtA transcript for degradation by RNase E. Magnesium 14-23 protein phosphatase 1 regulatory subunit 8 Homo sapiens 105-112 18270171-3 2008 Here we show that open HCN channels (the hyperpolarization-activated, cyclic nucleotide sensitive pore forming subunits of I(H)) undergo a fast, voltage-dependent block by intracellular Mg in a manner that suggests the ion binds close to, or within, the selectivity filter. Magnesium 186-188 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 23-26 18319565-4 2008 Mutations that changed Asn616 of the NR1a subunit, a critical residue for Mg(2+) blocking of NMDA receptors, to Arg (N616R) or Gln (N616Q) almost eliminated the inhibitory effects of timolol and betaxolol, as well as the blocking effect of Mg(2+). Magnesium 74-76 nodal homolog 1 L homeolog Xenopus laevis 37-41 18557135-7 2008 We here show that exposure to IL-1 and IL-6 significantly increased the levels of DCF-detectable ROS in cells cultured in physiologic concentrations of Mg, but not in Mg-deprived cells. Magnesium 152-154 interleukin 1 alpha Homo sapiens 30-34 18557135-7 2008 We here show that exposure to IL-1 and IL-6 significantly increased the levels of DCF-detectable ROS in cells cultured in physiologic concentrations of Mg, but not in Mg-deprived cells. Magnesium 152-154 interleukin 6 Homo sapiens 39-43 18327408-10 2008 This effect is likely to be mediated through VWF as Mg(++) partially inhibited ristocetin-induced platelet aggregation and VWF binding to collagen. Magnesium 52-58 von Willebrand factor Homo sapiens 45-48 18327408-10 2008 This effect is likely to be mediated through VWF as Mg(++) partially inhibited ristocetin-induced platelet aggregation and VWF binding to collagen. Magnesium 52-58 von Willebrand factor Homo sapiens 123-126 18057121-10 2008 MMgT1 and MMgT2 mRNA increased by about threefold, respectively, in kidney epithelial cells cultured in low-magnesium media relative to normal media and in the kidney cortex of mice maintained on low-magnesium diets compared with those animals consuming normal diets. Magnesium 108-117 membrane magnesium transporter 1 Mus musculus 0-5 18166196-6 2008 When purified MP20 tetramers are reconstituted with native lens lipids in the presence of magnesium, MP20 forms two-dimensional (2D) crystals. Magnesium 90-99 lens intrinsic membrane protein 2 Homo sapiens 14-18 18166196-6 2008 When purified MP20 tetramers are reconstituted with native lens lipids in the presence of magnesium, MP20 forms two-dimensional (2D) crystals. Magnesium 90-99 lens intrinsic membrane protein 2 Homo sapiens 101-105 18057121-10 2008 MMgT1 and MMgT2 mRNA increased by about threefold, respectively, in kidney epithelial cells cultured in low-magnesium media relative to normal media and in the kidney cortex of mice maintained on low-magnesium diets compared with those animals consuming normal diets. Magnesium 108-117 membrane magnesium transporter 2 Mus musculus 10-15 18085632-8 2008 EPMA revealed lower concentrations of Ca, P, and Mg in the klotho-deficient dentin, except for the dentin around abnormal odontoblast-like cells. Magnesium 49-51 klotho Mus musculus 59-65 18088596-1 2008 Structural analysis of MRP1-NBD1 revealed that the Walker A S685 forms hydrogen-bond with the Walker B D792 and interacts with magnesium and the beta-phosphate of the bound ATP. Magnesium 127-136 ATP binding cassette subfamily C member 1 Homo sapiens 23-27 18088596-8 2008 In contrast, substitution of the S685 with threonine yielded complex-glycosylated mature protein that is more active than the wild-type MRP1, indicating that the interaction between the hydroxyl group of 685 residue and the carboxyl group of D792 plays a crucial role for the protein folding and the interactions of the hydroxyl group at 685 with magnesium and the beta-phosphate of the bound ATP play an important role for ATP-binding and ATP-dependent solute transport. Magnesium 347-356 ATP binding cassette subfamily C member 1 Homo sapiens 136-140 18196987-5 2008 Magnesium acts as a mild calcium antagonist on vascular smooth muscle tone, and on postreceptor insulin signaling; it is critically involved in energy metabolism, fatty acid synthesis, glucose utilization, ATPase functions, release of neurotransmitters, and endothelial cell function and secretion. Magnesium 0-9 insulin Homo sapiens 96-103 18196987-5 2008 Magnesium acts as a mild calcium antagonist on vascular smooth muscle tone, and on postreceptor insulin signaling; it is critically involved in energy metabolism, fatty acid synthesis, glucose utilization, ATPase functions, release of neurotransmitters, and endothelial cell function and secretion. Magnesium 0-9 dynein axonemal heavy chain 8 Homo sapiens 206-212 17933863-7 2008 The effect of magnesium treatment on AQP4 expression was determined by Western blot analysis. Magnesium 14-23 aquaporin 4 Rattus norvegicus 37-41 17242865-1 2007 Chaperonin GroEL assists protein folding in the presence of ATP and magnesium. Magnesium 68-77 heat shock protein family D (Hsp60) member 1 Homo sapiens 11-16 18156367-8 2008 Calcium and magnesium modulated LPCAT activity of both Aytl1 and -2 proteins that exhibit EF-hand motifs at the C terminus. Magnesium 12-21 lysophosphatidylcholine acyltransferase 1 Homo sapiens 32-37 18156367-8 2008 Calcium and magnesium modulated LPCAT activity of both Aytl1 and -2 proteins that exhibit EF-hand motifs at the C terminus. Magnesium 12-21 lysophosphatidylcholine acyltransferase 2 Homo sapiens 55-67 17976367-0 2008 Activation of a polyvalent cation-sensing receptor decreases magnesium transport via claudin-16. Magnesium 61-70 calcium sensing receptor Canis lupus familiaris 27-50 17976367-0 2008 Activation of a polyvalent cation-sensing receptor decreases magnesium transport via claudin-16. Magnesium 61-70 claudin 16 Canis lupus familiaris 85-95 17976367-2 2008 The expression of claudin-16 increased magnesium transport in Madin-Darby canine kidney (MDCK) cells. Magnesium 39-48 claudin 16 Canis lupus familiaris 18-28 17976367-3 2008 Little is known about the regulatory mechanism of magnesium transport via claudin-16. Magnesium 50-59 claudin 16 Canis lupus familiaris 74-84 17976367-4 2008 Here we examined the effect of a polyvalent cation-sensing receptor (CaSR) on the intracellular distribution of and transport of magnesium by claudin-16. Magnesium 129-138 calcium sensing receptor Canis lupus familiaris 44-67 17976367-4 2008 Here we examined the effect of a polyvalent cation-sensing receptor (CaSR) on the intracellular distribution of and transport of magnesium by claudin-16. Magnesium 129-138 calcium sensing receptor Canis lupus familiaris 69-73 17976367-4 2008 Here we examined the effect of a polyvalent cation-sensing receptor (CaSR) on the intracellular distribution of and transport of magnesium by claudin-16. Magnesium 129-138 claudin 16 Canis lupus familiaris 142-152 17976367-6 2008 The activation of CaSR by magnesium, calcium, neomycin, and gadolinium did not affect the expression of FLAG-tagged claudin-16, CaSR, or ZO-1, a tight junctional scaffolding protein. Magnesium 26-35 calcium sensing receptor Canis lupus familiaris 18-22 17976367-11 2008 The expression of FLAG-tagged claudin-16 increased transepithelial electrical resistance (TER) and transepithelial magnesium transport without affecting FITC-dextran (MW 4000) flux. Magnesium 115-124 claudin 16 Canis lupus familiaris 30-40 17976367-12 2008 The activation of CaSR decreased TER and magnesium transport, which were recovered by co-treatment with dibutyryl cAMP, a membrane-permeable cAMP analogue. Magnesium 41-50 calcium sensing receptor Canis lupus familiaris 18-22 17976367-13 2008 Taken together, CaSR activation may decrease PKA activity, resulting in a decrease in phosphorylated claudin-16, the translocation of claudin-16 to lysosome and a decrease in magnesium reabsorption. Magnesium 175-184 calcium sensing receptor Canis lupus familiaris 16-20 18769037-0 2008 Inhibition of the magnesium-sensitive TRPM7-like channel in cardiac myocytes by nonhydrolysable GTP analogs: involvement of phosphoinositide metabolism. Magnesium 18-27 transient receptor potential cation channel subfamily M member 7 Sus scrofa 38-43 18769037-1 2008 BACKGROUND/AIMS: A magnesium-inhibited, transient receptor potential melastatin 7 (TRPM7)-like channel is expressed in cardiac cell membranes. Magnesium 19-28 transient receptor potential cation channel subfamily M member 7 Sus scrofa 40-81 18769037-1 2008 BACKGROUND/AIMS: A magnesium-inhibited, transient receptor potential melastatin 7 (TRPM7)-like channel is expressed in cardiac cell membranes. Magnesium 19-28 transient receptor potential cation channel subfamily M member 7 Sus scrofa 83-88 18317951-2 2008 We assessed whether low serum levels of total calcium in patients with SAH treated with magnesium is mediated by parathyroid hormone (PTH) or calcitriol, and whether increased PTH or low serum levels of ionized calcium are associated with an increased risk of DCI and poor outcome. Magnesium 88-97 parathyroid hormone Homo sapiens 113-132 18317951-4 2008 Mean serum magnesium during treatment was related to mean serum levels of ionized calcium, PTH and calcitriol with linear regression. Magnesium 11-20 parathyroid hormone Homo sapiens 91-94 18179221-4 2008 The stereochemical outcome was rationalized by coordination of the magnesium atom to the quinuclidine nitrogen, thus directing the nucleophilic attack at the C-9 stereogenic center. Magnesium 67-76 complement C9 Homo sapiens 158-161 18032526-5 2008 We examined the effects of two defined AGEs N(epsilon)-carboxy-methyl-lysine (CML) and methyl-glyoxal derivatives (MG) on these cellular pathways and their functional relationship to AGER1 in human embryonic kidney cells (HEK293). Magnesium 115-117 dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Homo sapiens 183-188 17559069-8 2008 The phosphorylated CLDN-16 elicited increases of transepithelial electrical resistance (TER) and transepithelial transport of Mg(2+). Magnesium 126-128 claudin 16 Canis lupus familiaris 19-26 17242865-2 2007 Recent studies have shown that several divalent cations other than magnesium induce conformational changes of GroEL, thereby influencing chaperonin-assisted protein folding, but little is known about the detailed mechanism for such actions. Magnesium 67-76 heat shock protein family D (Hsp60) member 1 Homo sapiens 110-115 17242865-4 2007 Of the divalent cations, not only magnesium, but also manganese ions enabled the functional refolding and release of 5,10-methylenetetrahydroforate reductase (METF) by GroEL. Magnesium 34-43 heat shock protein family D (Hsp60) member 1 Homo sapiens 168-173 18021175-4 2007 RESULTS: Genetic expression of TRPM6 and TRPM7 was shown in human osteoblast-like MG-63, SaOS and U2-OS cells, and reduction of extracellular Mg2+ or Ca2+ led to a decrease of cell proliferation. Magnesium 82-84 transient receptor potential cation channel subfamily M member 6 Homo sapiens 31-36 18021175-4 2007 RESULTS: Genetic expression of TRPM6 and TRPM7 was shown in human osteoblast-like MG-63, SaOS and U2-OS cells, and reduction of extracellular Mg2+ or Ca2+ led to a decrease of cell proliferation. Magnesium 82-84 transient receptor potential cation channel subfamily M member 7 Homo sapiens 41-46 17973860-0 2007 Protective effects of magnesium against ischaemia-reperfusion injury through inhibition of P-selectin in rats. Magnesium 22-31 selectin P Rattus norvegicus 91-101 17973860-14 2007 These results suggest that the expression of P-selectin and CD11b is upregulated after reperfusion and magnesium pretreatment plays a cardioprotective role in ischaemia-reperfusion injury, possibly by inhibiting the upregulation of P-selectin expression. Magnesium 103-112 selectin P Rattus norvegicus 45-55 17973860-14 2007 These results suggest that the expression of P-selectin and CD11b is upregulated after reperfusion and magnesium pretreatment plays a cardioprotective role in ischaemia-reperfusion injury, possibly by inhibiting the upregulation of P-selectin expression. Magnesium 103-112 selectin P Rattus norvegicus 232-242 17657590-4 2007 Magnesium deficiency alone induced a significant increase in neutrophil infiltration and increased vascular ICAM-1 expression, in the absence of changes in mucosal injury or expression of proinflammatory mediators. Magnesium 0-9 intercellular adhesion molecule 1 Rattus norvegicus 108-114 18048993-5 2007 Intravenous administration of Mg not only improved these electrolyte abnormalities but also increased serum levels of intact PTH, bone formation markers, 1,25-dihydroxyvitamin D, as well as bone resorption markers in the urine, and lowered urinary phosphate reabsorption. Magnesium 30-32 parathyroid hormone Homo sapiens 125-128 17657590-5 2007 Magnesium deficiency was associated with hyposecretory epithelial cell responses and vascular macromolecular leak in the small intestine and lung, which was attributed partly to reduced expression of NOS-3. Magnesium 0-9 nitric oxide synthase 3 Rattus norvegicus 200-205 17197162-3 2007 Subjects with lower magnesium intake showed significantly higher fasting glucose, insulin and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) levels. Magnesium 20-29 insulin Homo sapiens 82-141 17197162-5 2007 Fasting insulin and HOMA-IR values were inversely associated with intakes of magnesium and fibres, and directly with Body Mass Index (BMI) and CUG. Magnesium 77-86 insulin Homo sapiens 8-15 17674164-6 2007 Of these, only Cyan-2 and DM-1 exhibited a large fluorescence enhancement in buffers, and were resistant to displacement by Mg(2+). Magnesium 124-126 immunoglobulin heavy diversity 1-7 Homo sapiens 26-30 17927169-1 2007 Magnesium and zinc complexes of the monoanionic ligands N,N"-bis(2,6-di-isopropylphenyl)triazenide, L1, N,N"-bis(2,6-di-isopropylphenyl)acetamidinate, L2, and N,N"-bis(2,6-di-isopropylphenyl)tert-butylamidinate, L3, have been synthesized, but only L3 possesses sufficient steric bulk to prevent bis-chelation. Magnesium 0-9 immunoglobulin kappa variable 2-14 (pseudogene) Homo sapiens 212-214 17927169-1 2007 Magnesium and zinc complexes of the monoanionic ligands N,N"-bis(2,6-di-isopropylphenyl)triazenide, L1, N,N"-bis(2,6-di-isopropylphenyl)acetamidinate, L2, and N,N"-bis(2,6-di-isopropylphenyl)tert-butylamidinate, L3, have been synthesized, but only L3 possesses sufficient steric bulk to prevent bis-chelation. Magnesium 0-9 immunoglobulin kappa variable 2-14 (pseudogene) Homo sapiens 248-250 17926032-7 2007 The deletion of ALR1 resulted in a decrease in intracellular magnesium levels. Magnesium 61-70 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 16-20 17926032-8 2007 An increase from 5 to 100 mM in the exogenous magnesium level increased the intracellular levels of magnesium in the alr1 and alr1 alr2 strains, whereas the expression of magnesium transporters from S. cerevisiae or Arabidopsis thaliana led to a change of the intracellular levels of magnesium in those strains. Magnesium 46-55 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 117-121 17926032-8 2007 An increase from 5 to 100 mM in the exogenous magnesium level increased the intracellular levels of magnesium in the alr1 and alr1 alr2 strains, whereas the expression of magnesium transporters from S. cerevisiae or Arabidopsis thaliana led to a change of the intracellular levels of magnesium in those strains. Magnesium 46-55 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 126-135 17926032-8 2007 An increase from 5 to 100 mM in the exogenous magnesium level increased the intracellular levels of magnesium in the alr1 and alr1 alr2 strains, whereas the expression of magnesium transporters from S. cerevisiae or Arabidopsis thaliana led to a change of the intracellular levels of magnesium in those strains. Magnesium 100-109 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 117-121 17926032-8 2007 An increase from 5 to 100 mM in the exogenous magnesium level increased the intracellular levels of magnesium in the alr1 and alr1 alr2 strains, whereas the expression of magnesium transporters from S. cerevisiae or Arabidopsis thaliana led to a change of the intracellular levels of magnesium in those strains. Magnesium 100-109 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 126-135 17926032-8 2007 An increase from 5 to 100 mM in the exogenous magnesium level increased the intracellular levels of magnesium in the alr1 and alr1 alr2 strains, whereas the expression of magnesium transporters from S. cerevisiae or Arabidopsis thaliana led to a change of the intracellular levels of magnesium in those strains. Magnesium 100-109 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 117-121 17926032-8 2007 An increase from 5 to 100 mM in the exogenous magnesium level increased the intracellular levels of magnesium in the alr1 and alr1 alr2 strains, whereas the expression of magnesium transporters from S. cerevisiae or Arabidopsis thaliana led to a change of the intracellular levels of magnesium in those strains. Magnesium 100-109 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 126-135 18219780-4 2007 Notably, CaSR-activated calcium transport is coupled to the presence of sufficient magnesium. Magnesium 83-92 calcium sensing receptor Homo sapiens 9-13 17760306-5 2007 Hepatic CAT activity increased linearly in birds fed with MgAsp or MgdiAsp (p < 0.01) and quadratically in birds fed with MgO (p < 0.05) as dietary Mg supplementation level increased. Magnesium 58-60 catalase Gallus gallus 8-11 17827267-7 2007 Although the substrate specificity of AtREV1 was rather narrow in the presence of magnesium ion, it widened in the presence of manganese ion. Magnesium 82-91 DNA-directed DNA polymerase Arabidopsis thaliana 38-44 17978577-4 2007 The functional moiety of alphaXbeta2, the alphaX I-domain, was found to bind plasminogen, the zymogen of plasmin, with moderate affinity (1.92 X 10-(6) M) in the presence of Mg(2+) or Mn(2+). Magnesium 174-176 plasminogen Homo sapiens 77-84 17532233-1 2007 This study was to examine the early responses of nuclear factor kappa B (NF-kappaB) to mechanical strains in MG-63. Magnesium 109-111 nuclear factor kappa B subunit 1 Homo sapiens 49-71 17532233-1 2007 This study was to examine the early responses of nuclear factor kappa B (NF-kappaB) to mechanical strains in MG-63. Magnesium 109-111 nuclear factor kappa B subunit 1 Homo sapiens 73-82 17786546-7 2007 Results show that alpha-lactalbumin exists in MG state at a particular concentration but lysozyme does not show features of MG state. Magnesium 46-48 lactalbumin alpha Bos taurus 18-35 17713891-5 2007 Though these data would seem to suggest a stronger P-O(H) bond in the magnesium complex compared to the magnesium-free case, the homolytic breaking of the P-O(H) bond in the complex is found to be easier, i.e., has a lower BDE. Magnesium 70-79 homeobox D13 Homo sapiens 223-226 17713891-5 2007 Though these data would seem to suggest a stronger P-O(H) bond in the magnesium complex compared to the magnesium-free case, the homolytic breaking of the P-O(H) bond in the complex is found to be easier, i.e., has a lower BDE. Magnesium 104-113 homeobox D13 Homo sapiens 223-226 17713891-6 2007 This effect is the result of the balance of several atomic contributions to the BDE induced by the magnesium cation, which stabilizes the dissociation product more than it stabilizes the intact model molecule. Magnesium 99-108 homeobox D13 Homo sapiens 80-83 17823441-2 2007 Transient receptor potential melastatin 7 (TRPM7) is a newly found gene essential to magnesium absorption and homeostasis. Magnesium 85-94 transient receptor potential cation channel subfamily M member 7 Homo sapiens 0-41 17823441-2 2007 Transient receptor potential melastatin 7 (TRPM7) is a newly found gene essential to magnesium absorption and homeostasis. Magnesium 85-94 transient receptor potential cation channel subfamily M member 7 Homo sapiens 43-48 17823441-3 2007 OBJECTIVE: We aimed to test whether the association of colorectal polyps with intake of calcium, magnesium, or both and Thr1482Ile polymorphism in the TRPM7 gene is modified by the Ca:Mg intake. Magnesium 97-106 transient receptor potential cation channel subfamily M member 7 Homo sapiens 151-156 17760306-9 2007 Supplemental MgAsp or MgdiAsp was more efficient to increase hepatic Mg concentrations, enhance hepatic CAT activity and its mRNA expression than MgO (p < 0.01). Magnesium 13-15 catalase Gallus gallus 104-107 17760306-10 2007 It can be concluded that dietary Mg supplementation could increase hepatic Mg concentration, enhance CAT mRNA expression and consequently enhance CAT activity, and the organic Mg (MgAsp or MgdiAsp) is much more efficient than the inorganic form (MgO). Magnesium 33-35 catalase Gallus gallus 101-104 17760306-10 2007 It can be concluded that dietary Mg supplementation could increase hepatic Mg concentration, enhance CAT mRNA expression and consequently enhance CAT activity, and the organic Mg (MgAsp or MgdiAsp) is much more efficient than the inorganic form (MgO). Magnesium 33-35 catalase Gallus gallus 146-149 17395433-2 2007 In this review, we describe how the functional properties of TRPM7 and TRPM2 are interconnected with calcium (Ca(2+)) and magnesium (Mg(2+)) homeostasis, oxidative stress, mitochondrial dysfunction, and immune mechanisms, all principal suspects in neurodegeneration. Magnesium 122-131 transient receptor potential cation channel subfamily M member 7 Homo sapiens 61-66 17395433-2 2007 In this review, we describe how the functional properties of TRPM7 and TRPM2 are interconnected with calcium (Ca(2+)) and magnesium (Mg(2+)) homeostasis, oxidative stress, mitochondrial dysfunction, and immune mechanisms, all principal suspects in neurodegeneration. Magnesium 122-131 transient receptor potential cation channel subfamily M member 2 Homo sapiens 71-76 17395433-2 2007 In this review, we describe how the functional properties of TRPM7 and TRPM2 are interconnected with calcium (Ca(2+)) and magnesium (Mg(2+)) homeostasis, oxidative stress, mitochondrial dysfunction, and immune mechanisms, all principal suspects in neurodegeneration. Magnesium 133-135 transient receptor potential cation channel subfamily M member 7 Homo sapiens 61-66 17395433-2 2007 In this review, we describe how the functional properties of TRPM7 and TRPM2 are interconnected with calcium (Ca(2+)) and magnesium (Mg(2+)) homeostasis, oxidative stress, mitochondrial dysfunction, and immune mechanisms, all principal suspects in neurodegeneration. Magnesium 133-135 transient receptor potential cation channel subfamily M member 2 Homo sapiens 71-76 17481860-0 2007 TRPM6 and TRPM7--Gatekeepers of human magnesium metabolism. Magnesium 38-47 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 17481860-0 2007 TRPM6 and TRPM7--Gatekeepers of human magnesium metabolism. Magnesium 38-47 transient receptor potential cation channel subfamily M member 7 Homo sapiens 10-15 17481860-4 2007 Patients with Hypomagnesemia with Secondary Hypocalcemia (HSH), a primary defect in intestinal magnesium absorption, were found to carry mutations in TRPM6, a member of the melastatin-related subfamily of transient receptor potential (TRP) ion channels. Magnesium 95-104 transient receptor potential cation channel subfamily M member 6 Homo sapiens 150-155 17481860-5 2007 Before, a close homologue of TRPM6, TRPM7, had been characterized as a magnesium and calcium permeable ion channel vital for cellular magnesium homeostasis. Magnesium 71-80 transient receptor potential cation channel subfamily M member 6 Homo sapiens 29-34 17481860-5 2007 Before, a close homologue of TRPM6, TRPM7, had been characterized as a magnesium and calcium permeable ion channel vital for cellular magnesium homeostasis. Magnesium 71-80 transient receptor potential cation channel subfamily M member 7 Homo sapiens 36-41 17481860-5 2007 Before, a close homologue of TRPM6, TRPM7, had been characterized as a magnesium and calcium permeable ion channel vital for cellular magnesium homeostasis. Magnesium 134-143 transient receptor potential cation channel subfamily M member 6 Homo sapiens 29-34 17481860-5 2007 Before, a close homologue of TRPM6, TRPM7, had been characterized as a magnesium and calcium permeable ion channel vital for cellular magnesium homeostasis. Magnesium 134-143 transient receptor potential cation channel subfamily M member 7 Homo sapiens 36-41 17635118-7 2007 TSG-6 is an essential co-factor and catalyst in this chain of events, with both TSG-6.HC formation and HC transfer being dependent on the presence of Mg(2+) or Mn(2+) ions. Magnesium 150-152 TNF alpha induced protein 6 Homo sapiens 0-5 17635118-7 2007 TSG-6 is an essential co-factor and catalyst in this chain of events, with both TSG-6.HC formation and HC transfer being dependent on the presence of Mg(2+) or Mn(2+) ions. Magnesium 150-152 TNF alpha induced protein 6 Homo sapiens 80-85 17922646-9 2007 However, in the presence of magnesium ions the level of XRCC1 modification increased upon APE1 addition, since APE1 creates nicked DNA duplex, which interacts with XRCC1 more efficiently. Magnesium 28-37 X-ray repair cross complementing 1 Homo sapiens 56-61 17922646-9 2007 However, in the presence of magnesium ions the level of XRCC1 modification increased upon APE1 addition, since APE1 creates nicked DNA duplex, which interacts with XRCC1 more efficiently. Magnesium 28-37 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 90-94 17922646-9 2007 However, in the presence of magnesium ions the level of XRCC1 modification increased upon APE1 addition, since APE1 creates nicked DNA duplex, which interacts with XRCC1 more efficiently. Magnesium 28-37 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 111-115 17922646-9 2007 However, in the presence of magnesium ions the level of XRCC1 modification increased upon APE1 addition, since APE1 creates nicked DNA duplex, which interacts with XRCC1 more efficiently. Magnesium 28-37 X-ray repair cross complementing 1 Homo sapiens 164-169 17660616-3 2007 Although calcium (Ca) is considered to be the major regulator of PTH secretion, a number of studies have demonstrated that Mg can modulate PTH secretion in a manner similar to Ca. Magnesium 123-125 parathyroid hormone Homo sapiens 139-142 17660616-4 2007 Especially, it has been suggested that intracellular Mg depletion impairs the ability of the parathyroid to secrete PTH resulting in a fall in the serum PTH levels, and subsequently a fall in the serum Ca concentration. Magnesium 53-55 parathyroid hormone Homo sapiens 116-119 17660616-4 2007 Especially, it has been suggested that intracellular Mg depletion impairs the ability of the parathyroid to secrete PTH resulting in a fall in the serum PTH levels, and subsequently a fall in the serum Ca concentration. Magnesium 53-55 parathyroid hormone Homo sapiens 153-156 17660622-3 2007 Investigation of hypomagnesemia-exhibiting inherited diseases revealed molecular mechanisms of Mg transport pathways; paracellin-1 as a passive paracellular transport and TRPM6 as an active transcellular transport. Magnesium 95-97 transient receptor potential cation channel subfamily M member 6 Homo sapiens 171-176 17671646-0 2007 When EGF is offside, magnesium is wasted. Magnesium 21-30 epidermal growth factor Homo sapiens 5-8 17671655-3 2007 Through the discovery of a mutation in the EGF gene in isolated autosomal recessive renal hypomagnesemia, we have, for what we believe is the first time, identified a magnesiotropic hormone crucial for total body Mg(2+) balance. Magnesium 213-215 epidermal growth factor Homo sapiens 43-46 17671655-5 2007 As a consequence, the renal EGFR is inadequately stimulated, resulting in insufficient activation of the epithelial Mg(2+) channel TRPM6 (transient receptor potential cation channel, subfamily M, member 6) and thereby Mg(2+) loss. Magnesium 116-118 epidermal growth factor receptor Homo sapiens 28-32 17671655-5 2007 As a consequence, the renal EGFR is inadequately stimulated, resulting in insufficient activation of the epithelial Mg(2+) channel TRPM6 (transient receptor potential cation channel, subfamily M, member 6) and thereby Mg(2+) loss. Magnesium 218-220 epidermal growth factor receptor Homo sapiens 28-32 17995699-0 2007 Egg yolk protein and egg yolk phosvitin inhibit calcium, magnesium, and iron absorptions in rats. Magnesium 57-66 casein kinase 2 beta Rattus norvegicus 30-39 17995699-2 2007 The effects of egg yolk protein and egg yolk phosvitin on the absorption of calcium, magnesium, and iron were investigated by in vivo studies. Magnesium 85-94 casein kinase 2 beta Rattus norvegicus 45-54 17995699-6 2007 The addition of egg yolk phosvitin to the casein diets at levels of 1% and 2% (w/w) produced effects on calcium and magnesium absorptions similar to those produced by the diet containing yolk protein. Magnesium 116-125 casein kinase 2 beta Rattus norvegicus 25-34 17590173-5 2007 A possible involvement of AIRE in the development of MG was suggested by the observation that medullary thymic epithelial cells isolated from AIRE-deficient mice contain low levels of RNA transcripts for CHRNA 1, a gene coding for acetylcholine receptor. Magnesium 53-55 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) Mus musculus 26-30 17590173-5 2007 A possible involvement of AIRE in the development of MG was suggested by the observation that medullary thymic epithelial cells isolated from AIRE-deficient mice contain low levels of RNA transcripts for CHRNA 1, a gene coding for acetylcholine receptor. Magnesium 53-55 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) Mus musculus 142-146 17590173-5 2007 A possible involvement of AIRE in the development of MG was suggested by the observation that medullary thymic epithelial cells isolated from AIRE-deficient mice contain low levels of RNA transcripts for CHRNA 1, a gene coding for acetylcholine receptor. Magnesium 53-55 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) Mus musculus 204-253 17954975-2 2007 The presence of Mg/ATP led to an appreciable decrease in the binding affinity of the alpha-globin chain to spectrin and the overall yield of globin-spectrin cross-linked complexes formed in the presence of hydrogen peroxide. Magnesium 16-18 hemoglobin subunit alpha 2 Homo sapiens 85-97 17918133-5 2007 Mutations in the claudin 16 (paracellin) paracellular protein in the thick ascending limb (TAL) of Henle"s loop and in the transient receptor potential cation channel, subfamily 6, member 6 (TRPM6) magnesium channel expressed in distal tubules found in patients with renal magnesium wasting and hypomagnesemia underscore the importance of these transport proteins. Magnesium 198-207 claudin 16 Homo sapiens 17-27 17918133-5 2007 Mutations in the claudin 16 (paracellin) paracellular protein in the thick ascending limb (TAL) of Henle"s loop and in the transient receptor potential cation channel, subfamily 6, member 6 (TRPM6) magnesium channel expressed in distal tubules found in patients with renal magnesium wasting and hypomagnesemia underscore the importance of these transport proteins. Magnesium 198-207 transient receptor potential cation channel subfamily M member 6 Homo sapiens 191-196 17918133-5 2007 Mutations in the claudin 16 (paracellin) paracellular protein in the thick ascending limb (TAL) of Henle"s loop and in the transient receptor potential cation channel, subfamily 6, member 6 (TRPM6) magnesium channel expressed in distal tubules found in patients with renal magnesium wasting and hypomagnesemia underscore the importance of these transport proteins. Magnesium 273-282 claudin 16 Homo sapiens 17-27 17918133-5 2007 Mutations in the claudin 16 (paracellin) paracellular protein in the thick ascending limb (TAL) of Henle"s loop and in the transient receptor potential cation channel, subfamily 6, member 6 (TRPM6) magnesium channel expressed in distal tubules found in patients with renal magnesium wasting and hypomagnesemia underscore the importance of these transport proteins. Magnesium 273-282 transient receptor potential cation channel subfamily M member 6 Homo sapiens 191-196 17918144-1 2007 Even though there are some functional similarities between the aged kidney and the chronically damaged one, such as the reduction in glomerular filtration rate and in the sodium-water reabsorption capability, there are many physiological differences between these two groups, as is the case of erythropoietin, urea, potassium, calcium, phosphorus and magnesium renal handling. Magnesium 351-360 erythropoietin Homo sapiens 294-308 17972459-0 2007 Do changes in S100beta protein correlate with serum magnesium concentrations in patients undergoing extracorporeal circulation? Magnesium 52-61 S100 calcium binding protein B Homo sapiens 14-22 17972459-4 2007 Therefore, analysis of the correlation between serum total Mg and S100beta concentrations may be important and interesting, particularly in patients undergoing surgical myocardial revascularization. Magnesium 59-61 S100 calcium binding protein B Homo sapiens 66-74 17972463-2 2007 Basic science research has implicated magnesium deficiency as a cause of insulin resistance which is related to hypertension, diabetes, hyperlipidemia and increased cardiovascular risk. Magnesium 38-47 insulin Homo sapiens 73-80 17970538-2 2007 The appropriate intake of fats, fibre, and minerals (sodium, calcium, magnesium, potassium) in their diets; may reduce the risk to develop hypertension and cardiovascular diseases, in the long-term. Magnesium 70-79 chromosome 10 open reading frame 90 Homo sapiens 26-30 17606256-12 2007 These results demonstrate that the combination of MG effectively treats alcoholic steatosis with CYP2E1 inhibition, which may be associated with the recovery of AMPK activity, promising that the combination therapy may constitute an advance in the development of clinical candidates for alcoholic steatosis. Magnesium 50-52 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 97-103 17700703-5 2007 The MgtE family of Mg2+ transporters is ubiquitously distributed in all phylogenetic domains, and human homologues have been functionally characterized and suggested to be involved in magnesium homeostasis. Magnesium 184-193 solute carrier family 41 member 1 Homo sapiens 4-8 17661504-4 2007 We study CaM complexes with the physiologically important ions of calcium (Ca2+) and magnesium (Mg2+) and also with two other ions, strontium (Sr2+) and lanthanum (La3+). Magnesium 85-94 calmodulin 1 Homo sapiens 9-12 17760306-6 2007 Hepatic CAT mRNA was linearly correlated with the dietary Mg supplementation level (p < 0.01). Magnesium 58-60 catalase Gallus gallus 8-11 17502108-7 2007 Further, magnesium ion (1mM) enhanced DNA nicking activity of Abeta. Magnesium 9-18 amyloid beta precursor protein Homo sapiens 62-67 17510191-6 2007 We find that hypotonicity facilitates TRPM7 at elevated intracellular magnesium and Mg.ATP (3-4 mm), but has no effect in the absence of these solutes. Magnesium 70-79 transient receptor potential cation channel subfamily M member 7 Homo sapiens 38-43 17510191-6 2007 We find that hypotonicity facilitates TRPM7 at elevated intracellular magnesium and Mg.ATP (3-4 mm), but has no effect in the absence of these solutes. Magnesium 84-86 transient receptor potential cation channel subfamily M member 7 Homo sapiens 38-43 17532339-5 2007 Consistent with the previous studies, two well-fixed magnesium ions are coordinated by five active site residues and five water molecules in the PDP1c catalytic center. Magnesium 53-62 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 145-149 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Magnesium 146-155 aquaporin 10 Homo sapiens 44-56 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Magnesium 146-155 solute carrier family 6 member 4 Homo sapiens 58-64 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Magnesium 146-155 transient receptor potential cation channel subfamily M member 6 Homo sapiens 66-71 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Magnesium 146-155 solute carrier family 23 member 1 Homo sapiens 73-80 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Magnesium 146-155 solute carrier family 30 member 4 Homo sapiens 85-92 17667214-1 2007 The increasing evidence for the clinical relevance of altered magnesium metabolism to states of altered insulin resistance confirms the role of magnesium deficit as a possible underlying common mechanism of the "insulin resistance" of hypertension and altered glucose tolerance. Magnesium 144-153 insulin Homo sapiens 212-219 17550236-7 2007 Furthermore, MG-262-induced CYP3A stabilization was associated with its polyubiquitylation, thereby verifying that native CYPs 3A were also degraded via UPD. Magnesium 13-15 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 28-33 17550236-7 2007 Furthermore, MG-262-induced CYP3A stabilization was associated with its polyubiquitylation, thereby verifying that native CYPs 3A were also degraded via UPD. Magnesium 13-15 uroporphyrinogen decarboxylase Rattus norvegicus 153-156 17389678-2 2007 Mutations in claudin-19, which is expressed in kidney, retina, and myelinated peripheral neurons, were identified in familial hypomagnesemia with hypercalciuria and nephrocalcinosis, a hereditary disease causing renal Mg(2+) and Ca(2+) wasting. Magnesium 218-220 claudin 19 Canis lupus familiaris 13-23 17667214-1 2007 The increasing evidence for the clinical relevance of altered magnesium metabolism to states of altered insulin resistance confirms the role of magnesium deficit as a possible underlying common mechanism of the "insulin resistance" of hypertension and altered glucose tolerance. Magnesium 62-71 insulin Homo sapiens 104-111 17551748-4 2007 In this paper we looked for evidence for paracellular calcium transport by investigating the presence and cellular localization of paracellin-1 (claudin-16) that has been implied in paracellular magnesium and calcium transport in the kidney. Magnesium 195-204 claudin 16 Homo sapiens 131-143 17551748-7 2007 In immunohistochemical studies paracellin-1 colocalised in the salivary excretory ducts with the tight junction proteins ZO-1 and occludin suggesting a potential role in paracellular calcium and magnesium transport. Magnesium 195-204 claudin 16 Homo sapiens 31-43 17551748-7 2007 In immunohistochemical studies paracellin-1 colocalised in the salivary excretory ducts with the tight junction proteins ZO-1 and occludin suggesting a potential role in paracellular calcium and magnesium transport. Magnesium 195-204 tight junction protein 1 Homo sapiens 121-138 17023049-6 2007 We report here that (MH)RyR1 shows more pronounced activation by Ca(2+), and is less sensitive to channel inhibition by Ca(2+) and Mg(2+), compared to (Wt)RyR1. Magnesium 131-133 ryanodine receptor 1 Homo sapiens 24-28 17479208-1 2007 BACKGROUND: Little is known about the relationship between serum magnesium (Mg) and C-reactive protein (CRP) in heart failure (HF). Magnesium 65-74 C-reactive protein Homo sapiens 84-102 17479208-1 2007 BACKGROUND: Little is known about the relationship between serum magnesium (Mg) and C-reactive protein (CRP) in heart failure (HF). Magnesium 65-74 C-reactive protein Homo sapiens 104-107 17479208-1 2007 BACKGROUND: Little is known about the relationship between serum magnesium (Mg) and C-reactive protein (CRP) in heart failure (HF). Magnesium 76-78 C-reactive protein Homo sapiens 84-102 17479208-2 2007 AIM OF THE STUDY: To investigate the relationship, if any, between serum Mg and CRP in HF patients and, concomitantly, to test a hypothesis that Mg supplementation might affect serum CRP levels. Magnesium 73-75 C-reactive protein Homo sapiens 80-83 17479208-2 2007 AIM OF THE STUDY: To investigate the relationship, if any, between serum Mg and CRP in HF patients and, concomitantly, to test a hypothesis that Mg supplementation might affect serum CRP levels. Magnesium 145-147 C-reactive protein Homo sapiens 183-186 17479208-11 2007 CONCLUSIONS: Oral Mg supplementation to HF patients significantly attenuates blood levels of CRP, a biomarker of inflammation. Magnesium 18-20 C-reactive protein Homo sapiens 93-96 17646727-1 2007 Magnesium (Mg) deficiency sometimes causes hypocalcemia with impaired PTH secretion although the precise mechanism remains unclear. Magnesium 0-9 parathyroid hormone Homo sapiens 70-73 17646727-1 2007 Magnesium (Mg) deficiency sometimes causes hypocalcemia with impaired PTH secretion although the precise mechanism remains unclear. Magnesium 11-13 parathyroid hormone Homo sapiens 70-73 17646727-5 2007 In contrast, the plasma Ca was promptly normalized following the start of Mg replacement, and brisk PTH response to hypocalcemic stimuli was obtained during the same test carried out a week after the Mg replacement. Magnesium 200-202 parathyroid hormone Homo sapiens 100-103 17646727-6 2007 The data in this case thus suggest that: a) the acute regulation of PTH release by plasma ionized Ca is lost in the patient with hypomagnesemic hypocalcemia, and b) Mg deficiency itself is likely to be a primary cause of this disorder because the hormone response was clearly restored after shortterm Mg replacement alone. Magnesium 165-167 parathyroid hormone Homo sapiens 68-71 17727783-7 2007 Coordination of BR with radionuclide study or single-fiber electromyography helps increase the differential diagnosis of spasm of eyelid and MG. Magnesium 141-143 chromosome 12 open reading frame 73 Homo sapiens 16-18 17547203-10 2007 Performance of the Pd/Mg particles in PCB spiked clays and sediment suggests that they may work well in such systems. Magnesium 22-24 pyruvate carboxylase Homo sapiens 38-41 17547203-11 2007 Finally, a mechanism for PCB dechlorination in Pd/Mg systems was proposed. Magnesium 50-52 pyruvate carboxylase Homo sapiens 25-28 17320039-5 2007 In hypotonic medium, magnesium and potassium ions have a protective effect on the release of enzymes and on the reactivity of cyto-c as electron acceptor from both sulfite and succinate; results which are consistent with the view that MOM preserves its identity and remains not permeable to exogenous cyto-c. Magnesium 21-30 cytochrome c, somatic Homo sapiens 126-132 17320039-5 2007 In hypotonic medium, magnesium and potassium ions have a protective effect on the release of enzymes and on the reactivity of cyto-c as electron acceptor from both sulfite and succinate; results which are consistent with the view that MOM preserves its identity and remains not permeable to exogenous cyto-c. Magnesium 21-30 cytochrome c, somatic Homo sapiens 301-307 17622311-7 2007 Atherosclerotic patients (CS1 and CS2) showed increased levels of MT, MCP-1, and RANTES, reduced NK cell cytotoxicity, and altered trace element concentrations (zinc, copper, magnesium, iron). Magnesium 175-184 chorionic somatomammotropin hormone 1 Homo sapiens 26-29 17622311-7 2007 Atherosclerotic patients (CS1 and CS2) showed increased levels of MT, MCP-1, and RANTES, reduced NK cell cytotoxicity, and altered trace element concentrations (zinc, copper, magnesium, iron). Magnesium 175-184 chorionic somatomammotropin hormone 2 Homo sapiens 34-37 17474740-2 2007 The magnesium compounds [(diox)MgPh2]infinity (1) and (thf)2Mg(NPh2)2 (2) show tetracoordinate metal atoms, whereas in (dme)2Ca(NPh2)2 (3), (thf)4Sr(NPh2)2 (4), and (thf)4Ba(NPh2)2 (5) the metals are 6-fold coordinated. Magnesium 4-13 neurexophilin 2 Homo sapiens 63-67 17474740-2 2007 The magnesium compounds [(diox)MgPh2]infinity (1) and (thf)2Mg(NPh2)2 (2) show tetracoordinate metal atoms, whereas in (dme)2Ca(NPh2)2 (3), (thf)4Sr(NPh2)2 (4), and (thf)4Ba(NPh2)2 (5) the metals are 6-fold coordinated. Magnesium 4-13 neurexophilin 2 Homo sapiens 128-132 17474740-2 2007 The magnesium compounds [(diox)MgPh2]infinity (1) and (thf)2Mg(NPh2)2 (2) show tetracoordinate metal atoms, whereas in (dme)2Ca(NPh2)2 (3), (thf)4Sr(NPh2)2 (4), and (thf)4Ba(NPh2)2 (5) the metals are 6-fold coordinated. Magnesium 4-13 neurexophilin 2 Homo sapiens 128-132 17474740-2 2007 The magnesium compounds [(diox)MgPh2]infinity (1) and (thf)2Mg(NPh2)2 (2) show tetracoordinate metal atoms, whereas in (dme)2Ca(NPh2)2 (3), (thf)4Sr(NPh2)2 (4), and (thf)4Ba(NPh2)2 (5) the metals are 6-fold coordinated. Magnesium 4-13 neurexophilin 2 Homo sapiens 128-132 17442678-6 2007 Claudin-16 knock-down (KD) mice exhibit chronic renal wasting of magnesium and calcium and develop renal nephrocalcinosis. Magnesium 65-74 claudin 16 Mus musculus 0-10 17196802-1 2007 The physical stability and the secondary structure of a glucagon-like peptide-1 derivative were investigated in the presence of the metal ions Al(3+), Zn(2+), Mg(2+), and K(+), known as possible leachables from container-closure systems. Magnesium 159-161 glucagon Homo sapiens 56-79 17485541-7 2007 The activity of muA is dependent on the divalent cations Mg(2+) or Mn(2+), but not Ca(2+) or Zn(2+). Magnesium 57-59 mu-A protein Avian orthoreovirus 16-19 17452788-0 2007 A Rac1-GDP trimer complex binds zinc with tetrahedral and octahedral coordination, displacing magnesium. Magnesium 94-103 Rac family small GTPase 1 Homo sapiens 2-6 17561819-8 2007 From P28, responses could be recorded in normal magnesium and comprised a dominant NMDA-mediated component and a non-NMDA mediated component. Magnesium 48-57 golgi SNAP receptor complex member 1 Homo sapiens 5-8 17428633-6 2007 We found a decrease in expression of NR2B NMDAR subunit and PSD-95 (P<0.05) shortly after insult (within 24 h), which may show that brief magnesium-free media treatment of primary cultured rat cortical neurons, an in vitro model of seizure brain injury, has a major influence on the expression of NR2B subunit and PSD-95. Magnesium 141-150 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 37-41 17428633-6 2007 We found a decrease in expression of NR2B NMDAR subunit and PSD-95 (P<0.05) shortly after insult (within 24 h), which may show that brief magnesium-free media treatment of primary cultured rat cortical neurons, an in vitro model of seizure brain injury, has a major influence on the expression of NR2B subunit and PSD-95. Magnesium 141-150 discs large MAGUK scaffold protein 4 Rattus norvegicus 60-66 17428633-6 2007 We found a decrease in expression of NR2B NMDAR subunit and PSD-95 (P<0.05) shortly after insult (within 24 h), which may show that brief magnesium-free media treatment of primary cultured rat cortical neurons, an in vitro model of seizure brain injury, has a major influence on the expression of NR2B subunit and PSD-95. Magnesium 141-150 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 300-304 17428633-6 2007 We found a decrease in expression of NR2B NMDAR subunit and PSD-95 (P<0.05) shortly after insult (within 24 h), which may show that brief magnesium-free media treatment of primary cultured rat cortical neurons, an in vitro model of seizure brain injury, has a major influence on the expression of NR2B subunit and PSD-95. Magnesium 141-150 discs large MAGUK scaffold protein 4 Rattus norvegicus 317-323 17551748-4 2007 In this paper we looked for evidence for paracellular calcium transport by investigating the presence and cellular localization of paracellin-1 (claudin-16) that has been implied in paracellular magnesium and calcium transport in the kidney. Magnesium 195-204 claudin 16 Homo sapiens 145-155 17466895-0 2007 Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study. Magnesium 0-9 epidermal growth factor receptor Homo sapiens 34-66 17466895-1 2007 BACKGROUND: Preliminary evidence suggests that magnesium wasting occurs in patients who are treated with epidermal-growth-factor receptor (EGFR)-targeting antibodies for colorectal cancer. Magnesium 47-56 epidermal growth factor receptor Homo sapiens 105-137 17466895-1 2007 BACKGROUND: Preliminary evidence suggests that magnesium wasting occurs in patients who are treated with epidermal-growth-factor receptor (EGFR)-targeting antibodies for colorectal cancer. Magnesium 47-56 epidermal growth factor receptor Homo sapiens 139-143 17466895-3 2007 We aimed to assess the incidence, characteristics, and predictive factors of magnesium wasting during treatment with EGFR-targeting antibodies, and to study the pathophysiology of this phenomenon. Magnesium 77-86 epidermal growth factor receptor Homo sapiens 117-121 17466895-4 2007 METHODS: We measured prospectively magnesium concentrations in a cohort of 98 patients with colorectal cancer treated with EGFR-targeting antibodies with or without combined chemotherapy. Magnesium 35-44 epidermal growth factor receptor Homo sapiens 123-127 17466895-10 2007 FINDINGS: 95 (97%) patients had decreasing serum magnesium concentrations during EGFR-targeting treatment compared with baseline measurements. Magnesium 49-58 epidermal growth factor receptor Homo sapiens 81-85 17466895-11 2007 The mean serum magnesium slope during EGFR-targeting treatment (with or without combined chemotherapy) was significantly lower compared with chemotherapy alone (-0.00157 mmol/L/day, SD 0.00162 [95% CI -0.00191 to -0.00123] vs 0.00014 mmol/L/day, SD -00076 [-0.00026 to 0.00055]; (t test, p < 0.0001). Magnesium 15-24 epidermal growth factor receptor Homo sapiens 38-42 17466895-13 2007 INTERPRETATION: EGFR-inhibiting antibodies compromised the renal magnesium retention capacity, leading to hypomagnesaemia in most patients. Magnesium 65-74 epidermal growth factor receptor Homo sapiens 16-20 17466895-15 2007 Our study suggests a pivotal role of the EGFR-signalling pathway in regulating magnesium homoeostasis. Magnesium 79-88 epidermal growth factor receptor Homo sapiens 41-45 17413107-6 2007 RESULTS: In age-adjusted linear regression analyses, magnesium intake was inversely associated with plasma concentrations of CRP (P for linear trend = 0.003), E-selectin (P = 0.001), and sICAM-1 (P = 0.03). Magnesium 53-62 C-reactive protein Homo sapiens 125-128 17413107-6 2007 RESULTS: In age-adjusted linear regression analyses, magnesium intake was inversely associated with plasma concentrations of CRP (P for linear trend = 0.003), E-selectin (P = 0.001), and sICAM-1 (P = 0.03). Magnesium 53-62 selectin E Homo sapiens 159-169 17413107-7 2007 After further adjustment for physical activity, smoking status, alcohol use, postmenopausal hormone use, and body mass index, dietary magnesium intake remained inversely associated with CRP and E-selectin. Magnesium 134-143 C-reactive protein Homo sapiens 186-189 17413107-7 2007 After further adjustment for physical activity, smoking status, alcohol use, postmenopausal hormone use, and body mass index, dietary magnesium intake remained inversely associated with CRP and E-selectin. Magnesium 134-143 selectin E Homo sapiens 194-204 17413107-8 2007 Multivariate-adjusted geometric means for women in the highest quintile of dietary magnesium intake were 24% lower for CRP (1.70 +/- 0.18 compared with 1.30 +/- 0.10 mg/dL; P for trend = 0.03) and 14% lower for E-selectin (48.5 +/- 1.84 compared with 41.9 +/- 1.58 ng/mL; P for trend = 0.01) than those for women in the lowest quintile. Magnesium 83-92 C-reactive protein Homo sapiens 119-122 17413107-8 2007 Multivariate-adjusted geometric means for women in the highest quintile of dietary magnesium intake were 24% lower for CRP (1.70 +/- 0.18 compared with 1.30 +/- 0.10 mg/dL; P for trend = 0.03) and 14% lower for E-selectin (48.5 +/- 1.84 compared with 41.9 +/- 1.58 ng/mL; P for trend = 0.01) than those for women in the lowest quintile. Magnesium 83-92 selectin E Homo sapiens 211-221 17307793-7 2007 Interestingly, MG state of HEWL at pH 12.7 transformed into another MG state (MG2) at 20% t-butanol (v/v), in which secondary structure is mainly beta sheets. Magnesium 15-17 mucin 7, secreted Homo sapiens 78-81 17307793-7 2007 Interestingly, MG state of HEWL at pH 12.7 transformed into another MG state (MG2) at 20% t-butanol (v/v), in which secondary structure is mainly beta sheets. Magnesium 68-70 mucin 7, secreted Homo sapiens 78-81 17229727-9 2007 This structure represents the first direct visualization of the binding mode for magnesium to hexokinase and thus allows for a better understanding of the catalytic mechanism proposed for the entire hexokinase family. Magnesium 81-90 hexokinase 1 Homo sapiens 94-104 17229727-9 2007 This structure represents the first direct visualization of the binding mode for magnesium to hexokinase and thus allows for a better understanding of the catalytic mechanism proposed for the entire hexokinase family. Magnesium 81-90 hexokinase 1 Homo sapiens 199-209 17166836-3 2007 Here, we show that reduced magnesium concentration enhances expression of NIPA1 suggesting a role in cellular magnesium metabolism. Magnesium 27-36 NIPA magnesium transporter 1 Homo sapiens 74-79 17166836-3 2007 Here, we show that reduced magnesium concentration enhances expression of NIPA1 suggesting a role in cellular magnesium metabolism. Magnesium 110-119 NIPA magnesium transporter 1 Homo sapiens 74-79 17166836-6 2007 As expected of a magnesium-responsive gene, we find that altered magnesium concentration leads to a redistribution between the endosomal compartment and the plasma membrane; high magnesium results in diminished cell surface NIPA1 whereas low magnesium leads to accumulation in early endosomes and recruitment to the plasma membrane. Magnesium 65-74 NIPA magnesium transporter 1 L homeolog Xenopus laevis 224-229 17166836-6 2007 As expected of a magnesium-responsive gene, we find that altered magnesium concentration leads to a redistribution between the endosomal compartment and the plasma membrane; high magnesium results in diminished cell surface NIPA1 whereas low magnesium leads to accumulation in early endosomes and recruitment to the plasma membrane. Magnesium 65-74 NIPA magnesium transporter 1 L homeolog Xenopus laevis 224-229 17166836-6 2007 As expected of a magnesium-responsive gene, we find that altered magnesium concentration leads to a redistribution between the endosomal compartment and the plasma membrane; high magnesium results in diminished cell surface NIPA1 whereas low magnesium leads to accumulation in early endosomes and recruitment to the plasma membrane. Magnesium 65-74 NIPA magnesium transporter 1 L homeolog Xenopus laevis 224-229 17197439-10 2007 We conclude that a functional defect in the putative pore of TRPM6/7 channel complexes is sufficient to impair body magnesium homeostasis. Magnesium 116-125 transient receptor potential cation channel subfamily M member 6 Homo sapiens 61-66 17306797-0 2007 Effect of magnesium ions on the thermal stability of human poly(A)-specific ribonuclease. Magnesium 10-19 poly(A)-specific ribonuclease Homo sapiens 59-88 17062842-9 2007 In the mother, earlier exposure to either IGF increased AIB uptake by visceral organs (P<0.014), whereas IGF-I also enhanced uptake of AIB by muscle (P=0.044) and MG uptake by visceral organs (P=0.016) and muscle (P=0.046). Magnesium 166-168 insulin-like growth factor I Cavia porcellus 108-113 17372382-2 2007 Also their application for the determination of zinc in insulin to control injection quality and magnesium in human urine for the diagnosis and treatment of magnesium deficiency was shown. Magnesium 97-106 insulin Homo sapiens 56-63 17372382-2 2007 Also their application for the determination of zinc in insulin to control injection quality and magnesium in human urine for the diagnosis and treatment of magnesium deficiency was shown. Magnesium 157-166 insulin Homo sapiens 56-63 17064762-7 2007 We further show that the other known calcium (and magnesium) influx pathway in mast cells, the TRPM7-like magnesium-nucleotide-regulated metal (MagNuM) current, is largely uncoupled from cell cycle regulation except in G1. Magnesium 50-59 transient receptor potential cation channel, subfamily M, member 7 Rattus norvegicus 95-100 17132865-5 2007 Bacterial expression of the cDNA in Escherichia coli demonstrated that the product specifically used CDP-ethanolamine as the phosphobase donor to produce PE with the activation by both Mn(2+) and Mg(2+). Magnesium 196-198 cut like homeobox 1 Homo sapiens 101-104 17582296-1 2007 OBJECTIVE: The effect of vascular endothelial growth factor(165) (VEGF(165)) on intracellular free magnesium ([Mg(2+)](i)) and the relationship between Mg(2+) and angiogenesis in human umbilical vein endothelial cells (HUVECs) were investigated in this study. Magnesium 99-108 vascular endothelial growth factor A Homo sapiens 66-70 17536486-1 2007 The objective of this study was to determine whether magnesium consumption is associated with inflammation (C-reactive protein [CRP]) in children. Magnesium 53-62 C-reactive protein Homo sapiens 108-126 17536486-1 2007 The objective of this study was to determine whether magnesium consumption is associated with inflammation (C-reactive protein [CRP]) in children. Magnesium 53-62 C-reactive protein Homo sapiens 128-131 17536492-3 2007 These estimations of Kapp and [Ligand]T allowed, not only a comparison between measured and calculated ionised magnesium and calcium concentrations ([Mg2+] and [Ca2+]) for Mg2+/ATP, Mg2+/EDTA and Ca2+/EGTA buffers but also a comparison amongst calculated values. Magnesium 111-120 mucin 7, secreted Homo sapiens 172-175 17536492-3 2007 These estimations of Kapp and [Ligand]T allowed, not only a comparison between measured and calculated ionised magnesium and calcium concentrations ([Mg2+] and [Ca2+]) for Mg2+/ATP, Mg2+/EDTA and Ca2+/EGTA buffers but also a comparison amongst calculated values. Magnesium 111-120 mucin 7, secreted Homo sapiens 172-175 17582296-1 2007 OBJECTIVE: The effect of vascular endothelial growth factor(165) (VEGF(165)) on intracellular free magnesium ([Mg(2+)](i)) and the relationship between Mg(2+) and angiogenesis in human umbilical vein endothelial cells (HUVECs) were investigated in this study. Magnesium 111-113 vascular endothelial growth factor A Homo sapiens 66-70 17582296-4 2007 The angiogenesis effects of VEGF(165) were observed in presence of 0 mmol/L, 1 mmol/L or 2 mmol/L of extracellular Mg(2+). Magnesium 115-117 vascular endothelial growth factor A Homo sapiens 28-32 17582296-6 2007 The angiogenesis induced by VEGF(165) was significantly inhibited cells with 0 mmol/L extracellular Mg(2+), the angiogenesis effects of VEGF(165) were similar in cells with 1 mmol/L and 2 mmol/L extracellular Mg(2+) and these effects could be blocked by SU1498. Magnesium 100-102 vascular endothelial growth factor A Homo sapiens 28-32 17174326-0 2007 Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: improved accuracy in studies of structural features and mutational effects. Magnesium 0-9 DNA polymerase beta Homo sapiens 66-85 17158446-6 2007 By varying time and the concentrations of lysine, Mg(2+), or LysRS, the adenylation of Hint was found to be dependent on the formation of lysyl-AMP. Magnesium 50-52 histidine triad nucleotide binding protein 1 Homo sapiens 87-91 17233618-6 2007 Experiments on gon-2,gtl-1 double mutants show that they have a severe growth defect that is ameliorated by the addition of high levels of Mg(2+) to the growth medium. Magnesium 139-141 Transient receptor potential channel Caenorhabditis elegans 15-20 17233618-6 2007 Experiments on gon-2,gtl-1 double mutants show that they have a severe growth defect that is ameliorated by the addition of high levels of Mg(2+) to the growth medium. Magnesium 139-141 LSDAT_euk domain-containing protein Caenorhabditis elegans 21-26 17233618-7 2007 gon-2,gtl-1 double mutants have defective magnesium homoeostasis and also have altered sensitivity to toxic levels of Ni(2+). Magnesium 42-51 Transient receptor potential channel Caenorhabditis elegans 0-5 17233618-7 2007 gon-2,gtl-1 double mutants have defective magnesium homoeostasis and also have altered sensitivity to toxic levels of Ni(2+). Magnesium 42-51 LSDAT_euk domain-containing protein Caenorhabditis elegans 6-11 17107948-3 2007 Here, we report the first structure for a RGK protein: the crystal structure of a truncated form of the human Gem protein (G domain plus the first part of the C-terminal extension) in complex with Mg.GDP at 2.1 A resolution. Magnesium 197-199 GTP binding protein overexpressed in skeletal muscle Homo sapiens 110-113 17285123-3 2007 Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance. Magnesium 89-98 insulin Homo sapiens 151-158 16808892-0 2007 Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Magnesium 0-9 insulin Homo sapiens 73-80 16808892-3 2007 Insulin and glucose are important regulators of Mg metabolism. Magnesium 48-50 insulin Homo sapiens 0-7 16808892-4 2007 Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose uptake and vascular tone. Magnesium 14-16 insulin Homo sapiens 48-55 16808892-4 2007 Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose uptake and vascular tone. Magnesium 14-16 insulin Homo sapiens 64-71 16808892-5 2007 Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, post-receptorial impairment in insulin action, and worsening of insulin resistance in diabetic patients. Magnesium 22-24 insulin Homo sapiens 119-126 16808892-5 2007 Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, post-receptorial impairment in insulin action, and worsening of insulin resistance in diabetic patients. Magnesium 22-24 insulin Homo sapiens 152-159 16808892-6 2007 Mg deficit has been proposed as a possible underlying common mechanism of the "insulin resistance" of different metabolic conditions. Magnesium 0-2 insulin Homo sapiens 79-86 17316554-2 2007 The central magnesium atoms of each of the putative primary electron acceptor chlorophylls, A(0), are unusually coordinated by the sulfur atom of methionine 688 of PsaA and 668 of PsaB, respectively. Magnesium 12-21 photosystem I P700 chlorophyll a apoprotein A2 Chlamydomonas reinhardtii 180-184 17298707-3 2007 The purpose of the present investigation was to test the hypothesis that treatment with a spray-dried mixture of chicory oligofructose and long-chain inulin (Synergy1; SYN1) would increase the absorption of both Ca and Mg and alter markers of bone turnover. Magnesium 219-221 synapsin I Homo sapiens 168-172 17298707-7 2007 Fractional absorption of Ca and Mg increased following SYN1 compared with placebo (P < 0.05). Magnesium 32-34 synapsin I Homo sapiens 55-59 17012227-3 2007 The properties of SVCT2 are modulated by Ca(2+)/Mg(2+) and a reciprocal functional interaction between Na(+) and ascorbic acid that defines the substrate binding order and the transport stoichiometry. Magnesium 48-50 solute carrier family 23 member 2 Homo sapiens 18-23 17012227-9 2007 Our data indicate that SVCT2 may switch between a number of states with characteristic properties, including an inactive conformation in the absence of Ca(2+)/Mg(2+). Magnesium 159-161 solute carrier family 23 member 2 Homo sapiens 23-28 17068342-8 2007 Recombinant IMPA2 exhibits IMPase activity, although maximal activity requires higher concentrations of magnesium and a higher pH. Magnesium 104-113 inositol monophosphatase 2 Homo sapiens 12-17 17068342-11 2007 Importantly, when using myo-inositol monophosphate as a substrate, the IMPase activity of IMPA2 was inhibited at high lithium and restricted magnesium concentrations. Magnesium 141-150 inositol monophosphatase 2 Homo sapiens 90-95 16951132-9 2007 Human neutrophil elastase (HNE) at 10(-8) M increased MG secretion in the sPLA(2)-exposed trachea compared with that in the control trachea, but methacholine at 10(-7) M did not. Magnesium 54-56 elastase, neutrophil expressed Homo sapiens 6-25 16951132-9 2007 Human neutrophil elastase (HNE) at 10(-8) M increased MG secretion in the sPLA(2)-exposed trachea compared with that in the control trachea, but methacholine at 10(-7) M did not. Magnesium 54-56 elastase, neutrophil expressed Homo sapiens 27-30 16951132-9 2007 Human neutrophil elastase (HNE) at 10(-8) M increased MG secretion in the sPLA(2)-exposed trachea compared with that in the control trachea, but methacholine at 10(-7) M did not. Magnesium 54-56 phospholipase A2 group X Homo sapiens 74-81 16951132-11 2007 sPLA(2) increased tracheal inflammation, MG secretion, and secretory hyperresponsiveness to HNE probably through enzymatic action rather than by activation of its receptor. Magnesium 41-43 phospholipase A2 group X Homo sapiens 0-7 17546709-0 2007 Atom-transfer radical addition (ATRA) and cyclization (ATRC) reactions catalyzed by a mixture of [RuCl(2)Cp*(PPh3)] and Magnesium. Magnesium 120-129 caveolin 1 Homo sapiens 109-113 17546709-2 2007 The combination of the ruthenium(III) complex [RuCl(2)Cp*(PPh3)] (Cp*: pentamethylcyclopentadienyl) with magnesium allows these reactions to be performed under mild conditions with high efficiency. Magnesium 105-114 caveolin 1 Homo sapiens 58-62 18417764-0 2007 Letter: collision-induced dissociation of [metal(L)(2)](2+) complexes (metal = Cu, Ca and Mg) of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine allows distinction of the acyl groups at the sn1 and sn2 positions. Magnesium 90-92 solute carrier family 38 member 3 Homo sapiens 191-194 18417764-0 2007 Letter: collision-induced dissociation of [metal(L)(2)](2+) complexes (metal = Cu, Ca and Mg) of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine allows distinction of the acyl groups at the sn1 and sn2 positions. Magnesium 90-92 solute carrier family 38 member 5 Homo sapiens 199-202 17898422-7 2007 Tobacco plants expressing activated CAX1 variants displayed hypersensitivity to ion imbalances, increased calcium accumulation, heightened concentrations of other mineral nutrients such as potassium, magnesium and manganese, and increased activity of tonoplast-enriched Ca(2+)/H(+) transport. Magnesium 200-209 cation exchanger 1 Arabidopsis thaliana 36-40 17347984-4 2007 Due to their location within the primary structure of Claudin-16, both mutations are suggested to interfere with renal paracellular magnesium conductance. Magnesium 132-141 claudin 16 Homo sapiens 54-64 16968712-0 2007 Development of LiF:Mg,Cu,Si TL material (new KLT-300) with a low-residual signal and high-thermal stability. Magnesium 19-21 LIF interleukin 6 family cytokine Homo sapiens 15-18 16968712-3 2007 Recently, LiF:Mg,Cu,Na,Si TL material was developed to overcome these drawbacks at the Korea Atomic Energy Research Institute, but it provided only marginal improvements in reducing the residual signal. Magnesium 14-16 LIF interleukin 6 family cytokine Homo sapiens 10-13 16968712-4 2007 The newly developed LiF:Mg,Cu,Si TL material has a significantly lower residual signal and a better stability to thermal treatments. Magnesium 24-26 LIF interleukin 6 family cytokine Homo sapiens 20-23 16968712-5 2007 In this article, the preparation method and some dosimetric properties (sensitivity and residual signal) of the new LiF:Mg,Cu,Si TL material are presented. Magnesium 120-122 LIF interleukin 6 family cytokine Homo sapiens 116-119 17365938-10 2007 A significant positive correlation was found between vitamin B1, vitamin B6, folate, potassium, iron, and magnesium; between uric acid and vitamin D; between blood creatinine level and dietary vitamin B1, vitamin B6, folate, vitamin C, potassium, iron, magnesium; between blood potassium level and dietary vitamin C only; and between blood cholesterol level and dietary vitamin D only (p < 0.01). Magnesium 106-115 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 61-75 16938269-2 2006 Ceramide formation from the hydrolysis of sphingomyelin is considered to be a major pathway of stress-induced ceramide production with magnesium-dependent neutral sphingomyelinase (N-SMase) identified as a prime candidate in this pathway. Magnesium 135-144 sphingomyelin phosphodiesterase 2 Homo sapiens 155-179 16938269-2 2006 Ceramide formation from the hydrolysis of sphingomyelin is considered to be a major pathway of stress-induced ceramide production with magnesium-dependent neutral sphingomyelinase (N-SMase) identified as a prime candidate in this pathway. Magnesium 135-144 sphingomyelin phosphodiesterase 2 Homo sapiens 181-188 17215889-8 2006 Thus, in HMSN-ACC patients with KCC3 mutants, RBC KCC activity, although indistinguishable from that of the control group, responded differently to biochemical stressors, such as thiol alkylation or Mg removal, thereby indirectly indicating an important contribution of KCC3 to overall KCC function and regulation. Magnesium 199-201 solute carrier family 12 member 6 Homo sapiens 32-36 16904632-0 2006 Excess magnesium inhibits excess calcium-induced matrix-mineralization and production of matrix gla protein (MGP) by ATDC5 cells. Magnesium 7-16 matrix Gla protein Mus musculus 89-107 17217624-8 2006 EA-derived cells expressing UBE2C are sensitive to treatment with MG-262 and to silencing of UBE2C, suggesting that patients with EAs overexpressing UBE2C may benefit from agents targeting this ubiquitin-conjugating enzyme. Magnesium 66-68 ubiquitin conjugating enzyme E2 C Homo sapiens 28-33 17033971-0 2006 Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Magnesium 83-92 claudin 19 Homo sapiens 37-47 17033971-0 2006 Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Magnesium 83-92 claudin 19 Homo sapiens 49-55 17096550-4 2006 LFA-1 binding to ICAM-1 and ICAM-2 was strengthened in the slow loading regime by the addition of Mg(2+). Magnesium 98-100 integrin subunit alpha L Homo sapiens 0-5 17096550-4 2006 LFA-1 binding to ICAM-1 and ICAM-2 was strengthened in the slow loading regime by the addition of Mg(2+). Magnesium 98-100 intercellular adhesion molecule 2 Homo sapiens 28-34 17125532-6 2006 A high intake of calcium, magnesium and potassium, together with a low sodium intake, is associated with protection against bone demineralisation, arterial hypertension, insulin resistance, and overall cardiovascular risk. Magnesium 26-35 insulin Homo sapiens 170-177 17028309-6 2006 Additionally, the activity of TPST-2, but not TPST-1, was stimulated in the presence of Mg(2+). Magnesium 88-90 tyrosylprotein sulfotransferase 2 Homo sapiens 30-36 16766113-4 2006 For both magnesium and calcium systems, the formation of ten M(i)PhyH(j)((12-2i-j)-) species was observed in the range 3< or =pH< or =7 with i=1, 2, 3 and j=3, 4, 5 (and i=3, j=2). Magnesium 9-18 phytanoyl-CoA 2-hydroxylase Homo sapiens 65-69 16901897-0 2006 Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase. Magnesium 0-9 N-methylpurine DNA glycosylase Homo sapiens 85-115 17022745-4 2006 The significance of the intradialytic changes of magnesium and their relation to parathyroid hormone (PTH) level and calcium changes during dialysis, and their relation to hypotensive episodes during dialysis are interesting. Magnesium 49-58 parathyroid hormone Homo sapiens 81-100 17031004-4 2006 RESULTS: We obtained similar profiles in terms of apoptosis and oxidative stress in primary cultures of human hepatocytes, as compared to rat hepatocytes, i.e. a Mg concentration-dependent effect on the caspase-3 activity and GSH levels after 72 h of culture, caspase-3 activity being highest and GSH levels being lowest in Mg-free cultures. Magnesium 162-164 caspase 3 Rattus norvegicus 203-212 17031004-4 2006 RESULTS: We obtained similar profiles in terms of apoptosis and oxidative stress in primary cultures of human hepatocytes, as compared to rat hepatocytes, i.e. a Mg concentration-dependent effect on the caspase-3 activity and GSH levels after 72 h of culture, caspase-3 activity being highest and GSH levels being lowest in Mg-free cultures. Magnesium 162-164 caspase 3 Rattus norvegicus 260-269 17031004-4 2006 RESULTS: We obtained similar profiles in terms of apoptosis and oxidative stress in primary cultures of human hepatocytes, as compared to rat hepatocytes, i.e. a Mg concentration-dependent effect on the caspase-3 activity and GSH levels after 72 h of culture, caspase-3 activity being highest and GSH levels being lowest in Mg-free cultures. Magnesium 324-326 caspase 3 Rattus norvegicus 203-212 17031004-6 2006 This was accompanied in Mg-deficient cultures by a decrease in both the caspase-3 activity and the lipid peroxidation. Magnesium 24-26 caspase 3 Homo sapiens 72-81 17031004-7 2006 However, when culturing hepatocytes with physiological Mg concentrations, an increase in both caspase-3 activity and lipid peroxidation was observed. Magnesium 55-57 caspase 3 Homo sapiens 94-103 17446160-5 2006 The K-Cl co-transport (KCC1/3/4) activated by the depletion of erythrocyte magnesium is inhibited by Magnesium pidolate; dipyridamole inhibits ion transports upon deoxygenation. Magnesium 75-84 solute carrier family 12 member 4 Homo sapiens 23-31 17229895-3 2006 METHODS: We examined cross-sectional associations between magnesium intake and fasting glucose and insulin, 2-hour post-challenge plasma glucose and insulin, and insulin resistance assessed by the homeostasis model (HOMA-IR) in 1223 men and 1485 women without diabetes from the Framingham Offspring cohort. Magnesium 58-67 insulin Homo sapiens 99-106 17229895-6 2006 RESULTS: After adjustment for potential confounding factors, magnesium intake was inversely associated with fasting insulin (mean: 29.9 vs 26.7 microU/mL in the lowest vs highest quintiles of magnesium intake; P trend <0.001), post-glucose challenge plasma insulin (86.4 vs 72 microU/mL; P trend <0.001), and HOMA-IR (7.0 vs 6.2; P trend <0.001). Magnesium 61-70 insulin Homo sapiens 116-123 17229895-6 2006 RESULTS: After adjustment for potential confounding factors, magnesium intake was inversely associated with fasting insulin (mean: 29.9 vs 26.7 microU/mL in the lowest vs highest quintiles of magnesium intake; P trend <0.001), post-glucose challenge plasma insulin (86.4 vs 72 microU/mL; P trend <0.001), and HOMA-IR (7.0 vs 6.2; P trend <0.001). Magnesium 61-70 insulin Homo sapiens 260-267 17229895-8 2006 CONCLUSIONS: Improved insulin sensitivity may be one mechanism by which higher dietary magnesium intake may reduce the risk of developing type 2 DM. Magnesium 87-96 insulin Homo sapiens 22-29 17004279-7 2006 Effective hydration numbers derived from the DRS spectra indicate that both Mg(2+) and SO(4) (2-) influence solvent water molecules beyond their first hydration spheres but that MgSO(4)(aq) is less strongly hydrated than the previously studied CuSO(4)(aq). Magnesium 76-78 sushi repeat containing protein X-linked Homo sapiens 45-48 17096550-4 2006 LFA-1 binding to ICAM-1 and ICAM-2 was strengthened in the slow loading regime by the addition of Mg(2+). Magnesium 98-100 intercellular adhesion molecule 1 Homo sapiens 17-23 16875891-11 2006 On the other hand, primary hyperparathyroidism and lower bone magnesium content may account for the lower BMD and impairments in bone strength of COX-2(-/-) mice. Magnesium 62-71 cytochrome c oxidase II, mitochondrial Mus musculus 146-151 17294989-2 2006 The aim of this study was to determine whether magnesium, in comparison with ketamine, attenuates tourniquet-induced hypertension and spinal c-fos mRNA expression. Magnesium 47-56 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 141-146 17294989-4 2006 Arterial blood pressure and c-fos mRNA expression at 60 min were higher in the control than in the magnesium and ketamine groups. Magnesium 99-108 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 28-33 17294989-7 2006 Magnesium and ketamine are equally effective in attenuating tourniquet-induced hypertension and spinal c-fos mRNA expression, suggesting that this effect may be due to reduced pain transmission. Magnesium 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 103-108 16982494-9 2006 Magnesium-exposed neonates had lower serum apo A-I levels, and they had higher apo B/apo A-I and HDL-C/apo A-I ratios when compared to controls. Magnesium 0-9 apolipoprotein B Homo sapiens 79-84 16707555-0 2006 ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes. Magnesium 31-40 transient receptor potential cation channel, subfamily M, member 7 Rattus norvegicus 52-57 16904632-0 2006 Excess magnesium inhibits excess calcium-induced matrix-mineralization and production of matrix gla protein (MGP) by ATDC5 cells. Magnesium 7-16 matrix Gla protein Mus musculus 109-112 16798801-2 2006 In solutions containing zero added calcium and 1 mM Mg, chicken Cx56 hemichannels were mostly closed at negative potentials and application of depolarizing voltage clamp steps elicited a slowly activating outward current. Magnesium 52-54 gap junction protein alpha 3 Gallus gallus 64-68 16965083-4 2006 The TOF profiles of ICH3+ and MgI+ fragment ions produced from Mg+-ICH3 complex with 266 and 355 nm photons showed clear but opposite recoil anisotropy to each other. Magnesium 63-66 caspase 5 Homo sapiens 20-24 16965083-4 2006 The TOF profiles of ICH3+ and MgI+ fragment ions produced from Mg+-ICH3 complex with 266 and 355 nm photons showed clear but opposite recoil anisotropy to each other. Magnesium 63-66 caspase 5 Homo sapiens 67-71 16965083-6 2006 For Mg+-FCH3 complex, CH3+ and MgF+ formed with a 266 nm photon had also spatial anisotropy, in which the TOF profile of MgF+ was almost opposite to that of MgI+. Magnesium 4-7 insulin like growth factor 1 Homo sapiens 31-34 16965083-6 2006 For Mg+-FCH3 complex, CH3+ and MgF+ formed with a 266 nm photon had also spatial anisotropy, in which the TOF profile of MgF+ was almost opposite to that of MgI+. Magnesium 4-7 insulin like growth factor 1 Homo sapiens 121-124 17172010-15 2006 In addition, magnesium is a cofactor of many enzymes localized either in neurons or in glial cells that control neuronal properties and synaptic plasticity such as protein-kinase C, calcium/calmodulin-dependent protein kinase II and serine racemase. Magnesium 13-22 serine racemase Homo sapiens 233-248 16685525-10 2006 Moreover, the biosynthetic activity of recombinant GLN2 was stimulated by more than tenfold by the presence of free Mg(2+). Magnesium 116-118 Gln2 Lotus japonicus 51-55 16970254-2 2006 This study was conducted to investigate the role of serum magnesium (Mg) in regulating the secretion of parathyroid hormone (PTH) by the parathyroid gland in patients on maintenance hemodialysis (HD). Magnesium 58-67 parathyroid hormone Homo sapiens 104-123 16970254-2 2006 This study was conducted to investigate the role of serum magnesium (Mg) in regulating the secretion of parathyroid hormone (PTH) by the parathyroid gland in patients on maintenance hemodialysis (HD). Magnesium 69-71 parathyroid hormone Homo sapiens 104-123 16828056-0 2006 Vascular endothelial growth factor increases the intracellular magnesium. Magnesium 63-72 vascular endothelial growth factor A Homo sapiens 0-34 16893193-8 2006 The catalytic activity of copurified ABCG5/G8 was characterized in detail, demonstrating low affinity for MgATP, a preference for Mg as a metal cofactor and ATP as a hydrolyzed substrate, and a pH optimum near 8.0. Magnesium 106-108 ATP binding cassette subfamily G member 5 Homo sapiens 37-42 16917500-3 2006 In a Mnk1 crystal structure, the activation segment is repositioned via a Mnk-specific sequence insertion at the N-terminal lobe with the following consequences: (i) the peptide substrate binding site is deconstructed, (ii) the interlobal cleft is narrowed, (iii) an essential Lys-Glu pair is disrupted and (iv) the magnesium-binding loop is locked into an ATP-competitive conformation. Magnesium 316-325 MAPK interacting serine/threonine kinase 1 Homo sapiens 5-9 16917500-3 2006 In a Mnk1 crystal structure, the activation segment is repositioned via a Mnk-specific sequence insertion at the N-terminal lobe with the following consequences: (i) the peptide substrate binding site is deconstructed, (ii) the interlobal cleft is narrowed, (iii) an essential Lys-Glu pair is disrupted and (iv) the magnesium-binding loop is locked into an ATP-competitive conformation. Magnesium 316-325 ATPase copper transporting alpha Homo sapiens 5-8 16861328-1 2006 Dairy intake has been inversely associated with insulin resistance, which may be partly due to the specific effects of calcium and magnesium. Magnesium 131-140 insulin Homo sapiens 48-55 16861328-7 2006 Furthermore, magnesium intake was associated with insulin sensitivity in a threshold fashion, with a Bayesian method-estimated threshold (325 mg) (beta=0.0607/100 mg, p=0.0008 for <325 mg of magnesium/day; and beta=-0.001/100 mg, p=0.82 for >or=325 mg of magnesium/day). Magnesium 13-22 insulin Homo sapiens 50-57 16861328-8 2006 This study suggests that magnesium and calcium intake specifically, but not dairy intake, is associated with insulin sensitivity. Magnesium 25-34 insulin Homo sapiens 109-116 17003272-0 2006 Insulin and glucose mediate opposite intracellular ionized magnesium variations in human lymphocytes. Magnesium 59-68 insulin Homo sapiens 0-7 17003272-1 2006 Insulin is capable of increasing intracellular magnesium, although very little is known about the effect of insulin on the biologically active fraction of magnesium, i.e. the ionized quota (Mg(i)(2+)), its interactions with glucose, and the cellular mechanisms involved in these processes. Magnesium 47-56 insulin Homo sapiens 0-7 17003272-2 2006 We studied the interactions of the effects of insulin and glucose on intracellular ionized magnesium in human lymphocytes. Magnesium 91-100 insulin Homo sapiens 46-53 17172005-2 2006 Exogenous magnesium (Mg) has been found to increase the activity of serotonin N-acetyltransferase, an enzyme in the pathway for melatonin synthesis; but no data have been found on the effect of Mg deficiency on plasma melatonin. Magnesium 10-19 aralkylamine N-acetyltransferase Rattus norvegicus 68-97 16705067-1 2006 CONTEXT: Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is caused by a dysfunction of Claudin-16 (CLDN16) and characterized by renal wasting of Mg(2+) and Ca(2+). Magnesium 170-172 claudin 16 Homo sapiens 124-130 16866878-10 2006 This similarity seems to be endowed by the conserved hydrogen bonding interactions with the guanine base-recognition loops and the magnesium ion that has a typical octahedral coordination shell identical to that in H-Ras. Magnesium 131-140 HRas proto-oncogene, GTPase Homo sapiens 215-220 16866716-10 2006 CONCLUSIONS: Compared to both controls and the MH(-) state, CSF Na(+) concentration increased in MH(+) independently from other clinical or pharmacological fluctuations, CSF concentrations of Ca(2+), Mg, and K(+), and blood plasma Na(+) levels. Magnesium 200-202 colony stimulating factor 2 Homo sapiens 60-63 16652371-1 2006 The p53-induced serine/threonine phosphatase, protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D) (or wild-type p53-induced phosphatase 1 (Wip1)), exhibits oncogenic activity in vitro and in vivo. Magnesium 69-78 transformation related protein 53, pseudogene Mus musculus 4-7 16652371-1 2006 The p53-induced serine/threonine phosphatase, protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D) (or wild-type p53-induced phosphatase 1 (Wip1)), exhibits oncogenic activity in vitro and in vivo. Magnesium 69-78 protein phosphatase 1D magnesium-dependent, delta isoform Mus musculus 116-151 16911085-0 2006 Possible effect of leptin on renal magnesium excretion in adolescent patients with type 1 diabetes. Magnesium 35-44 leptin Homo sapiens 19-25 16911085-11 2006 CONCLUSION: The data suggest that serum leptin might be related to increased urinary Mg loss in patients with type I diabetes. Magnesium 85-87 leptin Homo sapiens 40-46 16473957-0 2006 Cardiac fibrogenesis in magnesium deficiency: a role for circulating angiotensin II and aldosterone. Magnesium 24-33 angiotensinogen Rattus norvegicus 69-83 16473957-7 2006 Circulating and cardiac tissue levels of angiotensin II were significantly elevated in magnesium-deficient animals (67.6% and 93.1%, respectively, vs. control). Magnesium 87-96 angiotensinogen Rattus norvegicus 41-55 16473957-8 2006 Plasma renin activity was 61.9% higher in magnesium-deficient rats, but serum angiotensin-converting enzyme activity was comparable in the two groups. Magnesium 42-51 renin Rattus norvegicus 7-12 16473957-9 2006 Furthermore, preliminary experiments in vivo using enalapril supported a role for angiotensin II in magnesium deficiency. Magnesium 100-109 angiotensinogen Rattus norvegicus 82-96 16473957-11 2006 The findings suggest that circulating angiotensin II and aldosterone may stimulate fibroblast activity and contribute to a fibrogenic response in the heart in magnesium deficiency. Magnesium 159-168 angiotensinogen Rattus norvegicus 38-52 16814108-5 2006 Compared to the standard and supplemented diets, the Mg-deficient diet significantly increased blood pressure, plasma interleukin-6, fibrinogen, and erythrocyte lysophosphatidylcholine, particularly in aging rats, it decreased plasma albumin. Magnesium 53-55 interleukin 6 Rattus norvegicus 118-131 16674916-3 2006 [(3)H]Quisqualic acid binding to mGluR1 required the presence of calcium (or magnesium) ions but not sodium or chloride ions while [(3)H]DCG-IV binding to mGluR3 was dependent upon both cations and anions. Magnesium 77-86 glutamate metabotropic receptor 1 Homo sapiens 33-39 16805805-4 2006 We demonstrated that, on proteasome inhibition with MG-132, PINK1 and other mitochondrial proteins localized to aggresomes. Magnesium 52-54 PTEN induced kinase 1 Homo sapiens 60-65 16624636-0 2006 Magnesium influences the discrimination and release of ADP by human RAD51. Magnesium 0-9 RAD51 recombinase Homo sapiens 68-73 16545962-7 2006 Inactive Rab11a formed dimers with unusually ordered Switch regions and missing the magnesium ion at the nucleotide binding site. Magnesium 84-93 RAB11A, member RAS oncogene family Homo sapiens 9-15 16545962-8 2006 In this work, inactive Rab11b crystallized as a monomer showing a flexible Switch I and a magnesium ion which is coordinated by four water molecules, the phosphate beta of GDP (beta-P) and the invariant S25. Magnesium 90-99 RAB11B, member RAS oncogene family Homo sapiens 23-29 16545962-8 2006 In this work, inactive Rab11b crystallized as a monomer showing a flexible Switch I and a magnesium ion which is coordinated by four water molecules, the phosphate beta of GDP (beta-P) and the invariant S25. Magnesium 90-99 ribosomal protein S25 Homo sapiens 203-206 16955720-6 2006 As total counts in blood, B-cells, CD4 and CD8 cells were significantly increased in the rats consuming the 30 ppm Mg diet. Magnesium 115-117 Cd4 molecule Rattus norvegicus 35-38 17080942-3 2006 We investigated the expression in Arabidopsis halleri of a homolog of AtMHX, an A. thaliana tonoplast transporter that exchanges protons with Mg, Zn and Fe ions. Magnesium 142-144 magnesium/proton exchanger Arabidopsis thaliana 70-75 16738137-6 2006 The TAR-2 extended form predominates with an increasing magnesium concentration. Magnesium 56-65 trace amine associated receptor 2 Homo sapiens 4-9 16338232-4 2006 The addition of n-alkyl trimethylammonium bromides to the unfolded state of cyt c in alkaline and acidic condition appears to support the stabilized form of the MG state. Magnesium 161-163 cytochrome c, somatic Equus caballus 76-81 16710121-6 2006 Serotonin is probably involved in aggressiveness induced by both moderate magnesium deficiency and low doses of THC, but implication of other neurotransmitters and magnesium deficiency-induced alterations of CB1-and/or CB2-receptor expression are not excluded. Magnesium 164-173 cannabinoid receptor 1 Rattus norvegicus 208-211 16359767-4 2006 Human Ap(3)Aase presents a native molecular mass of approximately 32 kDa and no significant differences were found in K(m) values (2 microM), activating effects by Mg(2+), Ca(2+), and Mn(2+), optimum pH (7.0-7.2) or inhibition by Zn(2+) and diethyl pyrocarbonate between the human enzyme and the recombinant Fhit protein. Magnesium 164-166 fragile histidine triad diadenosine triphosphatase Homo sapiens 6-15 16722031-3 2006 We reviewed all published studies on the relationship between serum magnesium and parathyroid hormone and the relationship between serum Mg and vascular calcification in dialysis patients. Magnesium 68-77 parathyroid hormone Homo sapiens 82-101 16722031-4 2006 Of these, 10 of 12 studies of patients on hemodialysis and 4 of 5 studies of patients on peritoneal dialysis showed a significantinverse relationship between serum Mg and serum intact parathyroid hormone. Magnesium 164-166 parathyroid hormone Homo sapiens 184-203 16464866-7 2006 PPAPDC2 activity was independent of Mg(2+) and optimal at pH 7.0 to 8.0. Magnesium 36-38 phospholipid phosphatase 6 Homo sapiens 0-7 16880936-3 2006 The interaction between calmodulin, and calcium and magnesium ions induced an increase in resonant frequency and a decrease in motional resistance, which were reversible on washing with buffer. Magnesium 52-61 calmodulin 1 Homo sapiens 24-34 16567569-10 2006 Magnesium intake was also inversely related to individual component of the metabolic syndrome and fasting insulin levels. Magnesium 0-9 insulin Homo sapiens 106-113 16533898-2 2006 While there is general consensus that the channel is inhibited by free intracellular Mg(2+), the functional roles of intracellular levels of Mg.ATP and the kinase domain in regulating TRPM7 channel activity have been discussed controversially. Magnesium 85-87 transient receptor potential cation channel subfamily M member 7 Homo sapiens 184-189 16533898-4 2006 We report here that physiological Mg.ATP concentrations can inhibit TRPM7 channels and strongly enhance the channel blocking efficacy of free Mg(2+). Magnesium 34-36 transient receptor potential cation channel subfamily M member 7 Homo sapiens 68-73 16757173-4 2006 AtUSP was activated by magnesium and preferred UTP as co-substrate. Magnesium 23-32 UDP-sugar pyrophosphorylase Arabidopsis thaliana 0-5 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Magnesium 272-281 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Magnesium 272-281 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Magnesium 272-281 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Magnesium 272-281 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Magnesium 283-285 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Magnesium 283-285 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Magnesium 283-285 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Magnesium 283-285 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16438932-14 2006 In the present study, the role of ERK1/2 activation on the PTH-dependent magnesium uptake was examined in MDCT cells, and we showed that immunosuppressants inhibit the hormone-stimulated Mg(2+) uptake into the MDCT cells by inhibiting the MAPK pathway. Magnesium 73-82 mitogen-activated protein kinase 3 Mus musculus 34-40 16438932-14 2006 In the present study, the role of ERK1/2 activation on the PTH-dependent magnesium uptake was examined in MDCT cells, and we showed that immunosuppressants inhibit the hormone-stimulated Mg(2+) uptake into the MDCT cells by inhibiting the MAPK pathway. Magnesium 73-82 parathyroid hormone Mus musculus 59-62 16619517-1 2006 BACKGROUND: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) in combination with a chemotherapeutic agent, cis-diammine dichloroplatinum (CDDP) or doxorubicin (DXR), has recently been demonstrated to result in enhanced apoptotic cell death in the sarcoma cell lines MG-63 and SaOS-2. Magnesium 287-289 TNF superfamily member 10 Homo sapiens 75-80 16619517-6 2006 Interestingly, partial inhibition of the cell death induced by the combined treatment with CDDP/DXR and TRAIL was found in MG-63 or SaOS-2 cells overexpressing dnJNK1, suggesting that JNK activation is required for the combined treatment. Magnesium 123-125 TNF superfamily member 10 Homo sapiens 104-109 16619517-6 2006 Interestingly, partial inhibition of the cell death induced by the combined treatment with CDDP/DXR and TRAIL was found in MG-63 or SaOS-2 cells overexpressing dnJNK1, suggesting that JNK activation is required for the combined treatment. Magnesium 123-125 mitogen-activated protein kinase 8 Homo sapiens 162-165 16619517-8 2006 CONCLUSION: Efficient cell death induced by combined treatment with the chemotherapeutic agents CDDP/DXR and TRAIL is involved in JNK activation in the sarcoma cell lines MG-63 and SaOS-2. Magnesium 171-173 TNF superfamily member 10 Homo sapiens 109-114 16619517-8 2006 CONCLUSION: Efficient cell death induced by combined treatment with the chemotherapeutic agents CDDP/DXR and TRAIL is involved in JNK activation in the sarcoma cell lines MG-63 and SaOS-2. Magnesium 171-173 mitogen-activated protein kinase 8 Homo sapiens 130-133 16339891-3 2006 These improvements were achieved by engineering magnesium and calcium-binding properties within the C-terminal lobe of troponin C and by the incorporation of circularly permuted variants of the green fluorescent protein. Magnesium 48-57 Troponin C isoform 4 Drosophila melanogaster 119-129 16155740-5 2006 Our results showed that erythrocyte Mg(2+) influx and efflux were respectively increased and decreased in nutritional Mg deficiency; while in genetically determined Mg status Mg(2+) fluxes were lower in MGL mice compared to MGH mice. Magnesium 36-38 C-type lectin domain family 10, member A Mus musculus 203-206 16819576-3 2006 In rodent models of dietary MgD, a significant rise in circulating levels of proinflammatory neuropeptides such as substance P (SP) and calcitonin gene-related peptide among others, was observed within days (1-7) of initiating the Mg-restricted diet, and implicated a neurogenic trigger for the subsequent inflammatory events; this early "neurogenic inflammation" phase may be mediated in part, by the Mg-gated N: -methyl-D-aspartate (NMDA) receptor/channel complex. Magnesium 28-30 tachykinin precursor 1 Homo sapiens 115-126 16819576-3 2006 In rodent models of dietary MgD, a significant rise in circulating levels of proinflammatory neuropeptides such as substance P (SP) and calcitonin gene-related peptide among others, was observed within days (1-7) of initiating the Mg-restricted diet, and implicated a neurogenic trigger for the subsequent inflammatory events; this early "neurogenic inflammation" phase may be mediated in part, by the Mg-gated N: -methyl-D-aspartate (NMDA) receptor/channel complex. Magnesium 231-233 tachykinin precursor 1 Homo sapiens 115-126 16522455-9 2006 Der p 1 exhibits a cysteine protease fold typical of the papain family, has a magnesium binding site, and forms dimers with a large interface. Magnesium 78-87 crystallin gamma F, pseudogene Homo sapiens 4-7 16564629-6 2006 A model of the average structure in the space group P6(3)/mmc with assumed composition Mg(2)Zn(5-x)Al(2+x), have been derived by Patterson analysis and intensity comparisons. Magnesium 87-89 tumor protein p63 Homo sapiens 52-57 16213650-7 2006 Moreover, in the presence of Mg(2+), the relative affinity of Rap2C for GTP was only about twofold higher than that for GDP, while, under the same conditions, Rap2B was able to bind GTP with about sevenfold higher affinity than GDP. Magnesium 29-31 RAP2C, member of RAS oncogene family Homo sapiens 62-67 16213650-7 2006 Moreover, in the presence of Mg(2+), the relative affinity of Rap2C for GTP was only about twofold higher than that for GDP, while, under the same conditions, Rap2B was able to bind GTP with about sevenfold higher affinity than GDP. Magnesium 29-31 RAP2B, member of RAS oncogene family Homo sapiens 159-164 16637322-6 2006 At the very early step of interaction with GTP, Mg2+ is reduced to Mg+, thus producing an ion radical pair (+)Mg-GTP(3-). Magnesium 67-70 mucin 7, secreted Homo sapiens 48-51 16536717-0 2006 An unusual cause of hypocalcaemia: magnesium induced inhibition of parathyroid hormone secretion in a patient with subarachnoid haemorrhage. Magnesium 35-44 parathyroid hormone Homo sapiens 67-86 16846096-3 2006 Serum osteocalcin level was significantly reduced with decreasing dietary Mg level. Magnesium 74-76 bone gamma-carboxyglutamate protein Rattus norvegicus 6-17 16846102-5 2006 Taken together, intrauterine magnesium deficiency in the fetus may lead to or program the insulin resistance after birth. Magnesium 29-38 insulin Homo sapiens 90-97 16511355-7 2006 Lon showed a strong tendency to form hexamers in the presence of Mg(2+), but dissociated into monomers and/or dimers in its absence. Magnesium 65-67 putative ATP-dependent Lon protease Escherichia coli 0-3 16490722-8 2006 The VDR mRNA content had a positive correlation with the plasma magnesium concentration. Magnesium 64-73 vitamin D receptor Bos taurus 4-7 16289054-4 2006 We find that the zero-magnesium-induced synchronized activity is blocked by inhibition of sarco-endoplasmic reticulum Ca(2+)-ATPases, phospholipase C (PLC), the inositol 1,4,5-trisphosphate (IP3) receptor, and the ryanodine receptor. Magnesium 22-31 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 191-204 16311277-6 2006 RESULTS: Magnesium groups required significantly less propofol [mean (sd) 121.5 (13.3), 102.2 (8.0) and 101.3 (9.7) microg kg(-1) min(-1) respectively] than the control group (140.7 (16.5) microg kg(-1) min(-1)). Magnesium 9-18 CD59 molecule (CD59 blood group) Homo sapiens 130-136 16311277-6 2006 RESULTS: Magnesium groups required significantly less propofol [mean (sd) 121.5 (13.3), 102.2 (8.0) and 101.3 (9.7) microg kg(-1) min(-1) respectively] than the control group (140.7 (16.5) microg kg(-1) min(-1)). Magnesium 9-18 CD59 molecule (CD59 blood group) Homo sapiens 203-209 16464075-1 2006 The three-coordinate, T-shaped Co(I) complex, PNPCo (PNP = [(tBu2PCH2SiMe2)2N-], is readily synthesized by magnesium reduction of divalent PNPCoCl. Magnesium 107-116 mitochondrially encoded cytochrome c oxidase I Homo sapiens 31-36 16208769-0 2006 A thermodynamic study on the interaction between magnesium ion and human growth hormone. Magnesium 49-58 growth hormone 1 Homo sapiens 73-87 16208769-1 2006 A thermodynamic study on the interaction between magnesium ion and human growth hormone (hGH) was studied at 27 degrees C in NaCl solution (50 mM) using different techniques. Magnesium 49-58 growth hormone 1 Homo sapiens 73-87 16671494-0 2006 Magnesium restores altered aquaporin-4 immunoreactivity following traumatic brain injury to a pre-injury state. Magnesium 0-9 aquaporin 4 Rattus norvegicus 27-38 16671494-3 2006 In this study, we characterize the effects of magnesium administration on AQP4 immunoreactivity following TBI. Magnesium 46-55 aquaporin 4 Rattus norvegicus 74-78 16671494-10 2006 We conclude that magnesium decreases brain edema formation after TBI, possibly by restoring the polarized state of astrocytes and by down-regulation of AQP4 channels in astrocytes. Magnesium 17-26 aquaporin 4 Rattus norvegicus 152-156 16328341-5 2006 In contrast to the other subtypes of NMDAR, NMDAR2D is characterized by low influence of magnesium to the receptor function. Magnesium 89-98 glutamate ionotropic receptor NMDA type subunit 2D Homo sapiens 44-51 16596461-3 2006 The mechanism underlying the blunted PTH response is unclear but may be related to magnesium (Mg) deficiency. Magnesium 83-92 parathyroid hormone Homo sapiens 37-40 16179484-5 2006 In addition, mdx-Na mice had elevated zinc and magnesium contents in their TA muscle. Magnesium 47-56 dystrophin, muscular dystrophy Mus musculus 13-16 16377938-0 2006 Effects of folic acid and magnesium on the production of homocysteine-induced extracellular matrix metalloproteinase-2 in cultured rat vascular smooth muscle cells. Magnesium 26-35 matrix metallopeptidase 2 Rattus norvegicus 92-118 16377938-2 2006 The aim of this study was to test whether homocysteine increases the production of matrix metalloproteinase-2 (MMP-2) and if extracellular additional magnesium and folic acid alters MMP-2 secretion. Magnesium 150-159 matrix metallopeptidase 2 Rattus norvegicus 182-187 16377938-6 2006 Magnesium also reduced the increase of MMP-2 production induced by homocysteine. Magnesium 0-9 matrix metallopeptidase 2 Rattus norvegicus 39-44 16377938-8 2006 Added extracellular folic acid and magnesium decreased the homocysteine-induced MMP-2 secretion. Magnesium 35-44 matrix metallopeptidase 2 Rattus norvegicus 80-85 16328501-0 2006 Residues of the yeast ALR1 protein that are critical for magnesium uptake. Magnesium 57-66 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 22-26 16328501-3 2006 Random PCR mutagenesis was undertaken of the C-terminal part of ALR1 that is homologous to the bacterial CorA magnesium transport family. Magnesium 110-119 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 64-68 16328501-8 2006 High expression of inactive mutants inhibited the capability of wild-type Alr1 to transport magnesium, consistent with Alr1 forming homo-oligomers. Magnesium 92-101 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 74-78 16719778-1 2006 Choline kinase (ChoK) is a cytosolic enzyme present in various tissues, which catalyzes the phosphorylation of choline to form phosphorylcholine (PCho) in the presence of ATP and magnesium. Magnesium 179-188 choline kinase alpha Mus musculus 16-20 16868704-0 2006 Inverse correlation between serum magnesium and parathyroid hormone in peritoneal dialysis patients: a contributing factor to adynamic bone disease? Magnesium 34-43 parathyroid hormone Homo sapiens 48-67 16868704-3 2006 Recent data suggests that serum magnesium may also modulate PTH levels. Magnesium 32-41 parathyroid hormone Homo sapiens 60-63 16868704-4 2006 OBJECTIVE: The aim of this retrospective study was to investigate the impact of different calcium (Ca) and magnesium (Mg) concentrations of dialysis solutions on serum Mg and serum PTH levels in peritoneal dialysis (PD) patients. Magnesium 107-116 parathyroid hormone Homo sapiens 181-184 16868704-4 2006 OBJECTIVE: The aim of this retrospective study was to investigate the impact of different calcium (Ca) and magnesium (Mg) concentrations of dialysis solutions on serum Mg and serum PTH levels in peritoneal dialysis (PD) patients. Magnesium 118-120 parathyroid hormone Homo sapiens 181-184 16868704-10 2006 There was a statistically significant inverse correlation between serum Mg and PTH levels (r = -0.357, p < 0.05). Magnesium 72-74 parathyroid hormone Homo sapiens 79-82 16868704-11 2006 CONCLUSION: Serum Mg is lower and serum PTH higher in patients dialyzed with lower Mg concentration dialysis solution compared to those with higher Mg concentration dialysis solution. Magnesium 83-85 parathyroid hormone Homo sapiens 40-43 16868704-12 2006 Our study confirms previous reports that serum Mg may have a suppressive role on PTH synthesis and/or secretion, and thus may play a role in pathogenesis of adynamic bone disease that often develops in patients on chronic PD with high calcium and high magnesium concentrations. Magnesium 47-49 parathyroid hormone Homo sapiens 81-84 17101715-0 2006 Overexpression of an Arabidopsis magnesium transport gene, AtMGT1, in Nicotiana benthamiana confers Al tolerance. Magnesium 33-42 magnesium transporter 1 Arabidopsis thaliana 59-65 17101715-4 2006 Here, the role of AtMGT1, a member of the Arabidopsis magnesium transport family involved in Mg(2+) transport, played in Al tolerance in higher plants was investigated. Magnesium 54-63 magnesium transporter 1 Arabidopsis thaliana 18-24 16274729-6 2006 Because of the reactivity MG and glycolytic intermediates, occasional glycolysis could be hormetic where glyoxalase, carnosine synthetase and ornithine decarboxylase are upregulated to control cellular MG concentration. Magnesium 26-28 ornithine decarboxylase 1 Homo sapiens 142-165 16274729-6 2006 Because of the reactivity MG and glycolytic intermediates, occasional glycolysis could be hormetic where glyoxalase, carnosine synthetase and ornithine decarboxylase are upregulated to control cellular MG concentration. Magnesium 202-204 ornithine decarboxylase 1 Homo sapiens 142-165 16474998-10 2006 In addition results show that magnesium prevented hypoxia-induced modification of the IP(3) receptor. Magnesium 30-39 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 86-100 16463102-6 2006 The results of these analyses suggest that SsChlI protein variants containing the substitutions identified in the dominant Oy1 maize alleles lack activity necessary for magnesium chelation and confer a semi-dominant phenotype via competitive inhibition of wild-type SsChlI. Magnesium 169-178 oil yellow 1 Zea mays 123-126 16752810-11 2006 Magnesium pre-treatment during hypoxia decreased number of nitrergic neurons in all areas of the hippocampus except CA1 area, where the effect of magnesium was not significant. Magnesium 0-9 carbonic anhydrase 1 Rattus norvegicus 116-119 16644966-4 2006 Its presence in optical grade single crystal LiF further suggests that it is an intrinsic defect or possibly associated with chance impurities other than Mg, Ti. Magnesium 154-156 LIF interleukin 6 family cytokine Homo sapiens 45-48 16644972-0 2006 Thermoluminescence emission spectra for the LiF:Mg,Cu,Na,Si thermoluminescent materials with various concentrations of the dopants (3-D measurement). Magnesium 48-50 LIF interleukin 6 family cytokine Homo sapiens 44-47 16735562-1 2006 Low temperature radioluminescence spectra of LiF, variously co-doped with Mg, Cu and P, show highly unusual temperature dependencies which resemble thermoluminescence data. Magnesium 74-76 LIF interleukin 6 family cytokine Homo sapiens 45-48 16596461-3 2006 The mechanism underlying the blunted PTH response is unclear but may be related to magnesium (Mg) deficiency. Magnesium 94-96 parathyroid hormone Homo sapiens 37-40 16601920-8 2006 The fall in serum Ca in the Mg-depleted animals was associated with a fall in serum PTH concentration between 3 and 6 months (603+/-286 and 505+/-302 pg/ml, respectively, although it was still higher than the control). Magnesium 28-30 parathyroid hormone Rattus norvegicus 84-87 16601920-14 2006 Relative to the control, immunohistochemical staining intensity of the neurotransmitter substance P and of the cytokines TNFalpha and IL-1beta was increased in cells of the bone microenvironment in the Mg depletion group, suggesting that inflammatory cytokines may contribute to bone loss. Magnesium 202-204 tumor necrosis factor Rattus norvegicus 121-129 16601920-14 2006 Relative to the control, immunohistochemical staining intensity of the neurotransmitter substance P and of the cytokines TNFalpha and IL-1beta was increased in cells of the bone microenvironment in the Mg depletion group, suggesting that inflammatory cytokines may contribute to bone loss. Magnesium 202-204 interleukin 1 beta Rattus norvegicus 134-142 16204247-3 2005 Relative to magnesium, calcium increased the affinity of Dmc1 for ATP and but reduces its DNA-dependent ATPase activity. Magnesium 12-21 recombinase DMC1 Saccharomyces cerevisiae S288C 57-61 16294275-12 2005 In co-cultures, where MG-63 or SaOS-2 cells were present, E2 and Te inhibited osteoclast formation in a dose-dependent manner. Magnesium 22-24 cystatin 12, pseudogene Homo sapiens 58-67 16199532-5 2005 In addition, calcium, magnesium, strontium, aluminum, gadolinium, and the calcimimetic NPS 568 resulted in a dose-dependent stimulation of GPRC6A overexpressed in human embryonic kidney cells 293 cells. Magnesium 22-31 G protein-coupled receptor class C group 6 member A Homo sapiens 139-145 16544020-5 2005 A negative correlation between intracellular magnesium levels (ICMg) and BMI and HbA1 was found. Magnesium 45-54 hemoglobin subunit alpha 1 Homo sapiens 81-85 16544020-7 2005 Despite the small number of patients, this study shows that magnesium deficiency is frequent in patients with diabetes and its correlation with insulin resistance should be more studied. Magnesium 60-69 insulin Homo sapiens 144-151 17101715-7 2006 Element assay showed that the contents of Mg, Mn, and Fe in 35S::AtMGT1 plants increased compared with wild-type plants. Magnesium 42-44 magnesium transporter 1 Arabidopsis thaliana 65-71 16272614-6 2005 Importantly, magnesium appears to play a pivotal role in regulating the PPAR-mediated signaling pathways as a key cofactor in the protein phosphorylation. Magnesium 13-22 peroxisome proliferator activated receptor alpha Homo sapiens 72-76 16269676-8 2005 Although corA encodes an Mg2+ transporter and at least three other inducible open reading frames belonged to the Mg2+ regulon, repression of the Mg stimulon by Mg2+ did not change the lactoperoxidase sensitivity of either the wild-type or corA mutant. Magnesium 25-27 Ni(2(+))/Co(2(+))/Mg(2(+)) transporter Escherichia coli str. K-12 substr. MG1655 9-13 15947931-8 2005 Vehicle treated rats on low Mg-intake had a significant reduction in the expression of Na,K-ATPase, NHE3 and NKCC2, but unchanged expression levels of AQP1 or AQP2 when compared to standard treated controls. Magnesium 28-30 solute carrier family 9 member A3 Rattus norvegicus 100-104 15947931-8 2005 Vehicle treated rats on low Mg-intake had a significant reduction in the expression of Na,K-ATPase, NHE3 and NKCC2, but unchanged expression levels of AQP1 or AQP2 when compared to standard treated controls. Magnesium 28-30 solute carrier family 12 member 1 Rattus norvegicus 109-114 16272614-8 2005 In this review, I focus on emerging knowledge about relationship between PPAR-mediated signals and magnesium. Magnesium 99-108 peroxisome proliferator activated receptor alpha Homo sapiens 73-77 16272615-6 2005 Magnesium is necessary the activity of lecithin cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL), which lowers triglyceride levels and raises HDL-cholesterol levels. Magnesium 0-9 lecithin-cholesterol acyltransferase Homo sapiens 39-75 16272615-6 2005 Magnesium is necessary the activity of lecithin cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL), which lowers triglyceride levels and raises HDL-cholesterol levels. Magnesium 0-9 lecithin-cholesterol acyltransferase Homo sapiens 77-81 16272615-6 2005 Magnesium is necessary the activity of lecithin cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL), which lowers triglyceride levels and raises HDL-cholesterol levels. Magnesium 0-9 lipoprotein lipase Homo sapiens 87-105 16272615-6 2005 Magnesium is necessary the activity of lecithin cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL), which lowers triglyceride levels and raises HDL-cholesterol levels. Magnesium 0-9 lipoprotein lipase Homo sapiens 107-110 16272620-5 2005 Taken together, chronic intrauterine magnesium deficiency in the fetus may lead to or program the insulin resistance after birth. Magnesium 37-46 insulin Homo sapiens 98-105 16241150-0 2005 Comparative study of the coordination chemistry and lactide polymerization of alkoxide and amide complexes of zinc and magnesium with a beta-diiminato ligand bearing ether substituents. Magnesium 119-128 amyloid beta precursor protein Homo sapiens 134-140 16207298-3 2005 The UV-A light-evoked decline in pineal AANAT activity was blocked by cAMP protagonists (forskolin and dibutyryl-cAMP) and by inhibitors of the proteasomal degradation pathway (MG-132, proteasome inhibitor I, and lactacystin). Magnesium 177-179 aralkylamine N-acetyltransferase Gallus gallus 40-45 16100107-8 2005 NMDMC uses Pi and magnesium to adapt an NADP binding site for NAD binding. Magnesium 18-27 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Homo sapiens 0-5 16181635-7 2005 Two nucleotides, U70 and U80, were found from chemical shift perturbation mapping to interact with the magnesium ion, with apparent K(d) values in the micromolar to millimolar range. Magnesium 103-112 small nucleolar RNA, H/ACA box 70 Homo sapiens 17-20 16181635-7 2005 Two nucleotides, U70 and U80, were found from chemical shift perturbation mapping to interact with the magnesium ion, with apparent K(d) values in the micromolar to millimolar range. Magnesium 103-112 small nucleolar RNA, C/D box 80 Homo sapiens 25-28 16143464-0 2005 Calcium and magnesium competitively influence the growth of a PMR1 deficient Saccharomyces cerevisiae strain. Magnesium 12-21 Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C 62-66 16143464-6 2005 Additionally, the novel magnesium sensitivity of PMR1 defective yeast is revealed, which appears to be a result of competition for uptake between Ca2+ and Mg2+ at the plasma membrane level. Magnesium 24-33 Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C 49-53 16157690-2 2005 Intracellular free magnesium (Mg(i)) inhibits L-type Ca(2+) currents through Ca(V)1.2 channels in cardiac myocytes, but the mechanism of this effect is unknown. Magnesium 19-28 immunoglobulin lambda variable 2-8 Homo sapiens 77-85 16157690-5 2005 In whole-cell patch clamp experiments, increased Mg(i) reduced both Ba(2+) and Ca(2+) currents conducted by wild type (WT) Ca(V)1.2 channels expressed in tsA-201 cells with similar affinity. Magnesium 49-51 immunoglobulin lambda variable 2-8 Homo sapiens 123-131 16157690-13 2005 These results support a novel mechanism linking the COOH-terminal EF-hand with modulation of Ca(V)1.2 channels by Mg(i). Magnesium 114-116 immunoglobulin lambda variable 2-8 Homo sapiens 93-101 16180088-0 2005 Intestinal and cardiac inflammatory response shows enhanced endotoxin receptor (CD14) expression in magnesium deficiency. Magnesium 100-109 CD14 molecule Rattus norvegicus 80-84 16047219-3 2005 Paracellin-1 belongs to the claudin family and regulates the paracellular transport of magnesium and calcium. Magnesium 87-96 claudin 16 Homo sapiens 0-12 16075242-0 2005 Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Magnesium 39-48 transient receptor potential cation channel subfamily M member 6 Homo sapiens 19-24 16075242-0 2005 Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Magnesium 68-77 transient receptor potential cation channel subfamily M member 6 Homo sapiens 19-24 16075242-6 2005 TRPM7 has been characterized functionally as a constitutively active ion channel permeable for a variety of cations including calcium and magnesium and regulated by intracellular concentrations of magnesium and/or magnesium-nucleotide complexes. Magnesium 138-147 transient receptor potential cation channel subfamily M member 7 Homo sapiens 0-5 16075242-6 2005 TRPM7 has been characterized functionally as a constitutively active ion channel permeable for a variety of cations including calcium and magnesium and regulated by intracellular concentrations of magnesium and/or magnesium-nucleotide complexes. Magnesium 197-206 transient receptor potential cation channel subfamily M member 7 Homo sapiens 0-5 16370207-3 2005 The promotors (oxalate, calcium, uric acid, phosphates) and inhibitors (citrate, magnesium) are statistically significant between G1, G2 and G3, G2. Magnesium 81-90 proline rich protein BstNI subfamily 3 Homo sapiens 130-147 16051611-6 2005 R6A-Galpha(i1) complexes are resistant to trypsin digestion and exhibit distinct stability in the presence of Mg(2+), suggesting that the R6A and GPR peptides exert their activities using different mechanisms. Magnesium 110-112 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 4-13 16162295-0 2005 Immunolocalization of RANKL is increased and OPG decreased during dietary magnesium deficiency in the rat. Magnesium 74-83 TNF superfamily member 11 Rattus norvegicus 22-27 16162295-0 2005 Immunolocalization of RANKL is increased and OPG decreased during dietary magnesium deficiency in the rat. Magnesium 74-83 TNF receptor superfamily member 11B Rattus norvegicus 45-48 16162295-8 2005 RESULTS: At all dietary Mg intakes, alteration in the presence of immunocytochemical staining of RANKL and OPG was observed. Magnesium 24-26 TNF superfamily member 11 Rattus norvegicus 97-102 16162295-8 2005 RESULTS: At all dietary Mg intakes, alteration in the presence of immunocytochemical staining of RANKL and OPG was observed. Magnesium 24-26 TNF receptor superfamily member 11B Rattus norvegicus 107-110 16162295-10 2005 CONCLUSION: We have, for the first time demonstrated that a reduction in dietary Mg in the rat alters the presence of RANKL and OPG and may explain the increase in osteoclast number and decrease in bone mass in this animal model. Magnesium 81-83 TNF superfamily member 11 Rattus norvegicus 118-123 16162295-10 2005 CONCLUSION: We have, for the first time demonstrated that a reduction in dietary Mg in the rat alters the presence of RANKL and OPG and may explain the increase in osteoclast number and decrease in bone mass in this animal model. Magnesium 81-83 TNF receptor superfamily member 11B Rattus norvegicus 128-131 16157808-7 2005 CONCLUSIONS: This report introduces a new CFEOM1 KIF21A mutation and is, to our knowledge, the first report of a genetic defect associated with MG. Magnesium 144-146 kinesin family member 21A Homo sapiens 42-48 16157808-7 2005 CONCLUSIONS: This report introduces a new CFEOM1 KIF21A mutation and is, to our knowledge, the first report of a genetic defect associated with MG. Magnesium 144-146 kinesin family member 21A Homo sapiens 49-55 16157808-8 2005 The combination of CFEOM1 with MG supports a primary neurogenic etiology of CFEOM resulting from KIF21A mutations. Magnesium 31-33 kinesin family member 21A Homo sapiens 97-103 15901795-3 2005 The specific site of memantine block in the NMDAR channel interacts with magnesium and is assumed to be at or near a narrow constriction representing the channel selectivity filter. Magnesium 73-82 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 44-49 16005094-6 2005 The presence of magnesium ions, free boron cationic monomer and mucin interfered with this uptake in a concentration-dependent manner. Magnesium 16-25 solute carrier family 13 member 2 Rattus norvegicus 64-69 15937149-8 2005 Although basal catalytic activity was refractory, ST-stimulated guanylyl cyclase C was inhibited by calcium, which antagonized binding of magnesium to allosteric sites required for receptor-effector coupling. Magnesium 138-147 guanylate cyclase 2C Homo sapiens 64-82 16106027-1 2005 We report that patients treated with cetuximab, a monoclonal antibody against the epithelial growth factor receptor (EGFR), occasionally develop a magnesium wasting syndrome with inappropriate urinary excretion. Magnesium 147-156 epidermal growth factor receptor Homo sapiens 82-115 16092876-2 2005 If E = SPh, a stereoselective generation of a quaternary center via a sequential Br/Mg- and sulfoxide/Mg-exchange can be achieved. Magnesium 84-86 surfactant associated 3 Homo sapiens 7-10 16092876-2 2005 If E = SPh, a stereoselective generation of a quaternary center via a sequential Br/Mg- and sulfoxide/Mg-exchange can be achieved. Magnesium 102-104 surfactant associated 3 Homo sapiens 7-10 16106027-1 2005 We report that patients treated with cetuximab, a monoclonal antibody against the epithelial growth factor receptor (EGFR), occasionally develop a magnesium wasting syndrome with inappropriate urinary excretion. Magnesium 147-156 epidermal growth factor receptor Homo sapiens 117-121 16106027-7 2005 Because EGFR is strongly expressed in the kidney, particularly in the ascending limb of the loop of Henle where 70% of filtered magnesium is reabsorbed, EGFR blockade may interfere with magnesium transport. Magnesium 128-137 epidermal growth factor receptor Homo sapiens 8-12 16106027-7 2005 Because EGFR is strongly expressed in the kidney, particularly in the ascending limb of the loop of Henle where 70% of filtered magnesium is reabsorbed, EGFR blockade may interfere with magnesium transport. Magnesium 186-195 epidermal growth factor receptor Homo sapiens 8-12 15958383-10 2005 Unlike ICAM-1 binding, which required only one activating agent, alpha(L) beta2/ICAM-3 binding required both Mg/EGTA and an activating mAb. Magnesium 109-111 intercellular adhesion molecule 3 Homo sapiens 80-86 15899945-10 2005 Moreover, ACDP2 mRNA is upregulated with magnesium deficiency, particularly in the distal convoluted tubule cells, kidney, heart, and brain. Magnesium 41-50 cyclin M2 Mus musculus 10-15 16051700-0 2005 A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. Magnesium 45-54 transient receptor potential cation channel subfamily M member 7 Homo sapiens 2-7 16051700-1 2005 Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+). Magnesium 175-184 phosphoglycerate dehydrogenase Homo sapiens 75-79 15892121-11 2005 The T(m) (3-->1) value is practically unchanged up to [Cd2+] approximately 10(-3)M. Differences between diagrams for Mg(2+) and Cd2+ result from the various kinds of ion binding to poly(rA).poly-(rU) and poly(rA). Magnesium 120-122 CD2 molecule Homo sapiens 58-61 15923157-9 2005 Mg depletion resulted in a significantly lower serum PTH concentrations. Magnesium 0-2 parathyroid hormone Rattus norvegicus 53-56 15923157-17 2005 These data demonstrate that Mg intake of 25% NR in the rat causes lower bone mass which may be related to increased release of substance P and TNFalpha. Magnesium 28-30 tumor necrosis factor Rattus norvegicus 143-151 15983014-6 2005 Transcript levels of Cab2 (encoding a chlorophyll a/b protein) were lower in Mg-deficient plants before any obvious decrease in the chlorophyll concentration. Magnesium 77-79 chlorophyll A/B-binding protein 2 Arabidopsis thaliana 21-25 16261999-1 2005 The content of calcium (Ca) and magnesium (Mg) in sweat during exercise is considerably higher during a relatively low intake of sodium (Na) of 100 mmol/d than with an intake of 170 mmol/d. Magnesium 32-41 SMU1 DNA replication regulator and spliceosomal factor Homo sapiens 30-31 16261999-1 2005 The content of calcium (Ca) and magnesium (Mg) in sweat during exercise is considerably higher during a relatively low intake of sodium (Na) of 100 mmol/d than with an intake of 170 mmol/d. Magnesium 32-41 SMU1 DNA replication regulator and spliceosomal factor Homo sapiens 56-57 16261999-1 2005 The content of calcium (Ca) and magnesium (Mg) in sweat during exercise is considerably higher during a relatively low intake of sodium (Na) of 100 mmol/d than with an intake of 170 mmol/d. Magnesium 43-45 SMU1 DNA replication regulator and spliceosomal factor Homo sapiens 30-31 16261999-1 2005 The content of calcium (Ca) and magnesium (Mg) in sweat during exercise is considerably higher during a relatively low intake of sodium (Na) of 100 mmol/d than with an intake of 170 mmol/d. Magnesium 43-45 SMU1 DNA replication regulator and spliceosomal factor Homo sapiens 56-57 15981006-4 2005 The aim of this study was to examine ways of manipulating the pHn of urine so that more of its calcium and magnesium remain in solution under alkaline conditions. Magnesium 107-116 carbamoyl-phosphate synthase 1 Homo sapiens 62-65 15981006-5 2005 The experimental data show that pHn can be elevated by decreasing the calcium, magnesium and phosphate concentrations. Magnesium 79-88 carbamoyl-phosphate synthase 1 Homo sapiens 32-35 16143978-7 2005 However, this study shows contrasting actions with the antibiotic rifampicin and magnesium addition leading to a decrease of the alpha-synuclein-herbicide interaction even if other metals are present in the bulk solvent. Magnesium 81-90 synuclein alpha Homo sapiens 129-144 16106027-7 2005 Because EGFR is strongly expressed in the kidney, particularly in the ascending limb of the loop of Henle where 70% of filtered magnesium is reabsorbed, EGFR blockade may interfere with magnesium transport. Magnesium 186-195 epidermal growth factor receptor Homo sapiens 153-157 15845589-2 2005 In the past few years, genetic studies in affected individuals disclosed the first molecular components of epithelial magnesium transport: the tight junction protein paracellin-1 (claudin-16) was discovered as a key player in paracellular magnesium and calcium reabsorption in the thick ascending limb of Henle"s loop and the gamma-subunit was identified as a component of renal Na+ -K+ -ATPase critical for transcellular magnesium reabsorption in the distal convoluted tubule. Magnesium 118-127 claudin 16 Homo sapiens 166-178 15845589-2 2005 In the past few years, genetic studies in affected individuals disclosed the first molecular components of epithelial magnesium transport: the tight junction protein paracellin-1 (claudin-16) was discovered as a key player in paracellular magnesium and calcium reabsorption in the thick ascending limb of Henle"s loop and the gamma-subunit was identified as a component of renal Na+ -K+ -ATPase critical for transcellular magnesium reabsorption in the distal convoluted tubule. Magnesium 118-127 claudin 16 Homo sapiens 180-190 15845589-2 2005 In the past few years, genetic studies in affected individuals disclosed the first molecular components of epithelial magnesium transport: the tight junction protein paracellin-1 (claudin-16) was discovered as a key player in paracellular magnesium and calcium reabsorption in the thick ascending limb of Henle"s loop and the gamma-subunit was identified as a component of renal Na+ -K+ -ATPase critical for transcellular magnesium reabsorption in the distal convoluted tubule. Magnesium 239-248 claudin 16 Homo sapiens 166-178 15845589-2 2005 In the past few years, genetic studies in affected individuals disclosed the first molecular components of epithelial magnesium transport: the tight junction protein paracellin-1 (claudin-16) was discovered as a key player in paracellular magnesium and calcium reabsorption in the thick ascending limb of Henle"s loop and the gamma-subunit was identified as a component of renal Na+ -K+ -ATPase critical for transcellular magnesium reabsorption in the distal convoluted tubule. Magnesium 239-248 claudin 16 Homo sapiens 180-190 15845589-2 2005 In the past few years, genetic studies in affected individuals disclosed the first molecular components of epithelial magnesium transport: the tight junction protein paracellin-1 (claudin-16) was discovered as a key player in paracellular magnesium and calcium reabsorption in the thick ascending limb of Henle"s loop and the gamma-subunit was identified as a component of renal Na+ -K+ -ATPase critical for transcellular magnesium reabsorption in the distal convoluted tubule. Magnesium 239-248 claudin 16 Homo sapiens 166-178 15845589-2 2005 In the past few years, genetic studies in affected individuals disclosed the first molecular components of epithelial magnesium transport: the tight junction protein paracellin-1 (claudin-16) was discovered as a key player in paracellular magnesium and calcium reabsorption in the thick ascending limb of Henle"s loop and the gamma-subunit was identified as a component of renal Na+ -K+ -ATPase critical for transcellular magnesium reabsorption in the distal convoluted tubule. Magnesium 239-248 claudin 16 Homo sapiens 180-190 15845589-6 2005 Whereas electrophysiological and biochemical analyses identified TRPM7 as an important player in cellular magnesium homeostasis, the critical role of TRPM6 for epithelial magnesium transport emerged from the discovery of loss-of-function mutations in patients with a severe form of hereditary hypomagnesaemia called primary hypomagnesaemia with secondary hypocalcaemia or HSH. Magnesium 171-180 transient receptor potential cation channel subfamily M member 6 Homo sapiens 150-155 15950075-1 2005 BACKGROUND: Epidemiological evidence shows a strong relationship between decreased serum magnesium levels (DSML) and insulin resistance. Magnesium 89-98 insulin Homo sapiens 117-124 16097940-3 2005 In the presence of magnesium ions, the active centers of transketolase initially identical in TDP binding lose their equivalence in the presence of donor substrates. Magnesium 19-28 transketolase Homo sapiens 57-70 16097940-4 2005 The stability of transketolase depended on the cation type used during its reconstitution--the holoenzyme reconstituted in the presence of calcium ions was more stable than the holoenzyme produced in the presence of magnesium ions. Magnesium 216-225 transketolase Homo sapiens 17-30 16813032-10 2005 In addition, the dominant cation in the Dead Sea solution--magnesium--probably exerts anti-inflammatory effects on the nasal mucosa and on the systemic immune response. Magnesium 59-68 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 45-48 15922739-6 2005 The results demonstrated that HAS-2 is the predominant HAS in MG-63. Magnesium 62-64 hyaluronan synthase 2 Homo sapiens 30-35 16004581-0 2005 Pre-Injury magnesium treatment prevents traumatic brain injury-induced hippocampal ERK activation, neuronal loss, and cognitive dysfunction in the radial-arm maze test. Magnesium 11-20 Eph receptor B1 Rattus norvegicus 83-86 16004581-1 2005 We studied the effect of pre-injury magnesium (Mg(2+)) treatment on hippocampal extracellular signal- regulated kinase (ERK) activation induced by lateral fluid-percussion (FP) brain injury, and on working and reference memory in the radial-arm maze test in rats subjected to such traumatic brain injury (TBI) (n = 56) or to sham injury (n = 12). Magnesium 36-45 Eph receptor B1 Rattus norvegicus 80-118 15948832-3 2005 cax1 mutants have most of the phenotypes associated with tolerance to serpentine soils, including survival in solutions with a low Ca(2+) : Mg(2+) ratio; requirement for a high concentration of Mg(2+) for maximum growth; reduced leaf tissue concentration of Mg(2+); and poor growth performance on "normal" levels of Ca(2+) and Mg(2+). Magnesium 140-142 cation exchanger 1 Arabidopsis thaliana 0-4 15948832-3 2005 cax1 mutants have most of the phenotypes associated with tolerance to serpentine soils, including survival in solutions with a low Ca(2+) : Mg(2+) ratio; requirement for a high concentration of Mg(2+) for maximum growth; reduced leaf tissue concentration of Mg(2+); and poor growth performance on "normal" levels of Ca(2+) and Mg(2+). Magnesium 194-196 cation exchanger 1 Arabidopsis thaliana 0-4 15913572-3 2005 The aim of this study is to verify the effect of the JSTX-3 on the epileptiform activity induced by magnesium-free medium in rat CA1 hippocampal neurons. Magnesium 100-109 carbonic anhydrase 1 Rattus norvegicus 129-132 15952789-0 2005 Magnesium, ADP, and actin binding linkage of myosin V: evidence for multiple myosin V-ADP and actomyosin V-ADP states. Magnesium 0-9 myosin VA Homo sapiens 45-53 15952789-4 2005 The two myosin V-MgADP states are of comparable energies, as indicated by the relatively equimolar partitioning at saturating magnesium. Magnesium 126-135 myosin VA Homo sapiens 8-16 15952789-10 2005 The data provide evidence for multiple myosin-ADP and actomyosin-ADP states and establish a kinetic and thermodynamic framework for defining the magnesium-dependent coupling between the actin and nucleotide binding sites of myosin. Magnesium 145-154 myosin heavy chain 14 Homo sapiens 39-45 15952789-10 2005 The data provide evidence for multiple myosin-ADP and actomyosin-ADP states and establish a kinetic and thermodynamic framework for defining the magnesium-dependent coupling between the actin and nucleotide binding sites of myosin. Magnesium 145-154 myosin heavy chain 14 Homo sapiens 58-64 16090332-3 2005 High-resolution transmission electron microscopy and density functional theory studies indicate that the atomically abrupt semiconducting GaN(111)/MgO(111) interface has a Mg-O-N-Ga stacking, where the N atom is bonded to O at a top site. Magnesium 147-149 gigaxonin Homo sapiens 138-141 15632318-4 2005 The interplay between homology modeling and site-directed mutagenesis suggested that Asp280 residue of P2X(4)R coordinates ATP binding via the magnesium ion, Phe230 residue coordinates the binding of the adenine ring of ATP, and Lys190, His286, and Arg278 residues coordinate the actions of negatively charged alpha-, beta-, and gamma-phosphate groups, respectively. Magnesium 143-152 purinergic receptor P2X 4 Homo sapiens 103-110 15920065-3 2005 RESULTS: In age- and BMI-adjusted analyses, magnesium intake was inversely associated with plasma C-reactive protein (CRP) concentrations; CRP concentrations were 12% lower in the highest intake quintile than in the lowest (P for trend <0.0001). Magnesium 44-53 C-reactive protein Homo sapiens 98-116 15920065-3 2005 RESULTS: In age- and BMI-adjusted analyses, magnesium intake was inversely associated with plasma C-reactive protein (CRP) concentrations; CRP concentrations were 12% lower in the highest intake quintile than in the lowest (P for trend <0.0001). Magnesium 44-53 C-reactive protein Homo sapiens 118-121 15920065-4 2005 This association was not appreciably altered by further adjustment for other potential confounding variables including dietary factors; the mean CRP concentrations for ascending quintiles of magnesium intake were 1.50, 1.39, 1.35, 1.34, and 1.31 mg/l (P for trend = 0.0003). Magnesium 191-200 C-reactive protein Homo sapiens 145-148 15869938-0 2005 Post-ischemic modest hypothermia (35 degrees C) combined with intravenous magnesium is more effective at reducing CA1 neuronal death than either treatment used alone following global cerebral ischemia in rats. Magnesium 74-83 carbonic anhydrase 1 Rattus norvegicus 114-117 15930481-3 2005 The objective of this study was to determine whether dietary magnesium consumption is associated with C-reactive protein (CRP), a marker of inflammation, in a nationally representative sample. Magnesium 61-70 C-reactive protein Homo sapiens 102-120 15930481-3 2005 The objective of this study was to determine whether dietary magnesium consumption is associated with C-reactive protein (CRP), a marker of inflammation, in a nationally representative sample. Magnesium 61-70 C-reactive protein Homo sapiens 122-125 15930481-7 2005 After controlling for demographic and cardiovascular risk factors, adults who consumed <RDA of magnesium were 1.48-1.75 times more likely to have elevated CRP than adults who consumed > or =RDA (Odds Ratio [OR] for intake <50% RDA = 1.75, 95% Confidence Interval [CI] 1.08-2.87). Magnesium 98-107 C-reactive protein Homo sapiens 158-161 15930481-8 2005 Adults who were over age 40 with a BMI >25 and who consumed <50% RDA for magnesium were 2.24 times more likely to have elevated CRP (95% CI 1.13-4.46) than adults > or =RDA. Magnesium 79-88 C-reactive protein Homo sapiens 134-137 16100847-5 2005 Serum osteocalcin levels (a biochemical marker of bone formation) were significantly lower in the two Mg-deficient groups than in the control group. Magnesium 102-104 bone gamma-carboxyglutamate protein Rattus norvegicus 6-17 15774836-8 2005 Taken together, these observations suggest that the basis for the altered renal magnesium and calcium handling in OD involves increased tubular transport activity and possibly increased sensitivity of these mechanisms to PTH. Magnesium 80-89 parathyroid hormone Rattus norvegicus 221-224 15883187-0 2005 Calcium- and magnesium-dependent interactions between calcium- and integrin-binding protein and the integrin alphaIIb cytoplasmic domain. Magnesium 13-22 centrin 1 Homo sapiens 54-91 15893593-0 2005 Magnesium blocks the loss of protein kinase C, leads to a transient translocation of PKC(alpha) and PKC(epsilon), and improves recovery after anoxia in rat hippocampal slices. Magnesium 0-9 protein kinase C, alpha Rattus norvegicus 85-95 15893593-6 2005 Magnesium treatment improved the recovery of synaptic transmission, blocked the loss of PKC and resulted in a transient translocation of PKC(alpha) and PKC(epsilon) to the membrane fraction. Magnesium 0-9 protein kinase C, alpha Rattus norvegicus 88-91 15893593-6 2005 Magnesium treatment improved the recovery of synaptic transmission, blocked the loss of PKC and resulted in a transient translocation of PKC(alpha) and PKC(epsilon) to the membrane fraction. Magnesium 0-9 protein kinase C, alpha Rattus norvegicus 137-147 15893593-8 2005 The mechanisms of magnesium neuroprotection may include altering the PKC response to an anoxic insult. Magnesium 18-27 protein kinase C, alpha Rattus norvegicus 69-72 15809054-1 2005 We have recently demonstrated that the human solute carrier, SLC41A1, is a Mg 2+ transporter that is regulated by extracellular magnesium. Magnesium 128-137 solute carrier family 41 member 1 Homo sapiens 61-68 15809054-4 2005 Further, real-time RT-PCR was performed to determine if SLC41A2 expression is regulated by magnesium. Magnesium 91-100 solute carrier family 41, member 2 Mus musculus 56-63 15809054-9 2005 These studies suggest that SLC41A2 is a Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells. Magnesium 83-92 solute carrier family 41, member 2 Mus musculus 27-34 15713785-10 2005 The SLC41A1 transcript is present in many tissues, notably renal epithelial cells, and is upregulated in some tissues with magnesium deficiency. Magnesium 123-132 solute carrier family 41, member 1 Mus musculus 4-11 15713785-11 2005 These studies suggest that SLC41A1 is a regulated Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells. Magnesium 93-102 solute carrier family 41, member 1 Mus musculus 27-34 15713785-11 2005 These studies suggest that SLC41A1 is a regulated Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells. Magnesium 93-102 mucin 7, secreted Homo sapiens 50-53 15925015-3 2005 Chromium, magnesium, and antioxidants are essential elements involved in the action of insulin and energetic metabolism, without serious adverse effects. Magnesium 10-19 insulin Homo sapiens 87-94 15855561-10 2005 Higher magnesium intake was also associated with increased plasma adiponectin. Magnesium 7-16 adiponectin, C1Q and collagen domain containing Homo sapiens 66-77 15855585-0 2005 Magnesium deficiency is associated with insulin resistance in obese children. Magnesium 0-9 insulin Homo sapiens 40-47 15855585-1 2005 OBJECTIVE: Magnesium deficiency has been associated with insulin resistance (IR) and increased risk for type 2 diabetes in adults. Magnesium 11-20 insulin Homo sapiens 57-64 15855585-6 2005 Serum magnesium was inversely correlated with fasting insulin (r(s) = -0.36 [95% CI -0.59 to -0.08]; P = 0.011) and positively correlated with quantitative insulin sensitivity check index (QUICKI) (0.35 [0.06-0.58]; P = 0.015). Magnesium 6-15 insulin Homo sapiens 54-61 15855585-6 2005 Serum magnesium was inversely correlated with fasting insulin (r(s) = -0.36 [95% CI -0.59 to -0.08]; P = 0.011) and positively correlated with quantitative insulin sensitivity check index (QUICKI) (0.35 [0.06-0.58]; P = 0.015). Magnesium 6-15 insulin Homo sapiens 156-163 15855585-8 2005 Dietary magnesium intake was inversely associated with fasting insulin (-0.43 [-0.64 to -0.16]; P = 0.002) and directly correlated with QUICKI (0.43 [0.16-0.64]; P = 0.002). Magnesium 8-17 insulin Homo sapiens 63-70 15769608-5 2005 Endostatin induced apoptosis in these cells in a caspase-dependent manner, and endostatin-mediated apoptosis is associated with several apoptotic signaling pathways including overloading of intracellular magnesium and calcium, as well as regulation of p53 and Bcl 2 expression. Magnesium 204-213 collagen type XVIII alpha 1 chain Homo sapiens 79-89 15885097-4 2005 The coordinated metal at the active site was predicted to be a zinc triad in rIAP-I, whereas the typical combination of two zinc atoms and one magnesium atom was proposed for rIAP-II. Magnesium 143-152 alkaline phosphatase 3, intestine, not Mn requiring Rattus norvegicus 175-182 15824853-14 2005 Relative hypoparathyroidism (human) and bone resistance to PTH (mice), mainly caused by Mg depletion, can explain the low bone remodeling and normal/low serum Ca despite increased renal Ca reabsorption. Magnesium 88-90 parathyroid hormone Homo sapiens 59-62 15821744-5 2005 Magnesium, known to induce a kink-turn in RNAs that contain two tandem G.A pairs, decreases the SBP2-SECIS complex in favor of the L30-SECIS interaction. Magnesium 0-9 SECIS binding protein 2 Homo sapiens 96-100 15936724-3 2005 In this study, we examined the effects of the proteasome inhibitors MG-132 and MG-262 on RANKL-induced osteoclast differentiation and function. Magnesium 68-70 TNF superfamily member 11 Homo sapiens 89-94 15936724-3 2005 In this study, we examined the effects of the proteasome inhibitors MG-132 and MG-262 on RANKL-induced osteoclast differentiation and function. Magnesium 79-81 TNF superfamily member 11 Homo sapiens 89-94 15939402-9 2005 Fluid shear flow experiments with MG-63 lacking PLC beta2 revealed a significantly higher level of cells losing attachment to coverslips and a significantly lower number of cells increasing intracellular free calcium. Magnesium 34-36 phospholipase C beta 2 Homo sapiens 48-57 15790516-6 2005 However, a 4 h IFN-gamma pretreatment augmented TNF-alpha secretion by peritoneal macrophages subsequently treated with an optimally stimulatory dose of MG. Magnesium 153-155 interferon gamma Mus musculus 15-24 15790516-6 2005 However, a 4 h IFN-gamma pretreatment augmented TNF-alpha secretion by peritoneal macrophages subsequently treated with an optimally stimulatory dose of MG. Magnesium 153-155 tumor necrosis factor Mus musculus 48-57 15790516-8 2005 Most interestingly, we found that IFN-gamma pretreatment of peritoneal macrophages enhanced the TNF-alpha response to amounts of MG that were poorly stimulatory or non-stimulatory in the absence of IFN-gamma priming. Magnesium 129-131 interferon gamma Mus musculus 34-43 15790516-8 2005 Most interestingly, we found that IFN-gamma pretreatment of peritoneal macrophages enhanced the TNF-alpha response to amounts of MG that were poorly stimulatory or non-stimulatory in the absence of IFN-gamma priming. Magnesium 129-131 tumor necrosis factor Mus musculus 96-105 15576443-6 2005 The dose-dependent dilation was mimicked by other known CaR agonists including magnesium (1-10 mM) and the aminoglycosides neomycin (0.003-10 mM) and kanamycin (0.003-3 mM). Magnesium 79-88 calcium-sensing receptor Rattus norvegicus 56-59 15804357-16 2005 Real-time reverse transcription polymerase chain reaction and Western blot analysis using a specific antibody demonstrated that MagT1 mRNA and protein is increased by about 2.1-fold and 32%, respectively, in kidney epithelial cells cultured in low magnesium media relative to normal media and in kidney cortex of mice maintained on low magnesium diets compared to those animals consuming normal diets. Magnesium 248-257 magnesium transporter 1 Mus musculus 128-133 15804357-16 2005 Real-time reverse transcription polymerase chain reaction and Western blot analysis using a specific antibody demonstrated that MagT1 mRNA and protein is increased by about 2.1-fold and 32%, respectively, in kidney epithelial cells cultured in low magnesium media relative to normal media and in kidney cortex of mice maintained on low magnesium diets compared to those animals consuming normal diets. Magnesium 336-345 magnesium transporter 1 Mus musculus 128-133 15843919-4 2005 On the other hand, TRPM8 and TRPA1 have been described as cold receptors, TRPM4 and TRPM5 as calcium-activated nonselective cation channels, TRPM6 and TRPM7 as magnesium-permeable and magnesium-modulated cation channels, TRPM2 as an ADP-ribose-activated channel of macrophages, and TRPM3 as a hypo-osmolarity- and sphingosine-activated channel. Magnesium 160-169 transient receptor potential cation channel subfamily M member 5 Homo sapiens 84-89 15843919-4 2005 On the other hand, TRPM8 and TRPA1 have been described as cold receptors, TRPM4 and TRPM5 as calcium-activated nonselective cation channels, TRPM6 and TRPM7 as magnesium-permeable and magnesium-modulated cation channels, TRPM2 as an ADP-ribose-activated channel of macrophages, and TRPM3 as a hypo-osmolarity- and sphingosine-activated channel. Magnesium 160-169 transient receptor potential cation channel subfamily M member 6 Homo sapiens 141-146 15843919-4 2005 On the other hand, TRPM8 and TRPA1 have been described as cold receptors, TRPM4 and TRPM5 as calcium-activated nonselective cation channels, TRPM6 and TRPM7 as magnesium-permeable and magnesium-modulated cation channels, TRPM2 as an ADP-ribose-activated channel of macrophages, and TRPM3 as a hypo-osmolarity- and sphingosine-activated channel. Magnesium 160-169 transient receptor potential cation channel subfamily M member 7 Homo sapiens 151-156 19791368-1 2005 Complexes of fluorinated benzenes (o-C6H4-nF2+n) and Mg*+ are subjected to ultraviolet photodissociation (260-340 nm), producing efficiently benzyne radical cations (C6H4-nFn*+) besides Mg*+ and MgF+. Magnesium 53-57 signal transducer and activator of transcription 5A Homo sapiens 195-198 15897476-9 2005 DISCUSSION: PDP1 is down-regulated in CLs of ObS because it is poorly sensitive to Mg/Ca; this defect is attenuated when plasma insulin is greatly enhanced. Magnesium 83-85 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 12-16 15735337-3 2005 The present contribution reports the rapid crystal structure determination of human UCK2 complexed with a magnesium ion and the reaction products adenosine 5"-diphosphate (ADP) and CMP. Magnesium 106-115 uridine-cytidine kinase 2 Homo sapiens 84-88 15661661-0 2005 Product inhibition and magnesium modulate the dual reaction mode of hOgg1. Magnesium 23-32 8-oxoguanine DNA glycosylase Homo sapiens 68-73 15661661-4 2005 This paper addresses the significance of product inhibition and magnesium for the non-concerted action of hOgg1 activities. Magnesium 64-73 8-oxoguanine DNA glycosylase Homo sapiens 106-111 15735337-6 2005 Two of the four major samarium sites are located in the active sites of the two UCK2 molecules that form the asymmetric unit and appear to displace the magnesium ions present in the native crystals. Magnesium 152-161 uridine-cytidine kinase 2 Homo sapiens 80-84 15661661-9 2005 Magnesium reduced the efficiency of base excision and strand incision on DNA containing 8-oxoG under single turnover conditions; however, the reduction was more pronounced for the AP-lyase activity. Magnesium 0-9 8-oxoguanine DNA glycosylase Homo sapiens 180-188 15661661-10 2005 Furthermore, Shiff-base formation between hOgg1 and 8-oxoG containing DNA was abrogated in the presence of magnesium. Magnesium 107-116 8-oxoguanine DNA glycosylase Homo sapiens 42-47 15865076-8 2005 Increases in the serum electrolytes potassium, magnesium and phosphate correlated positively with increases in free PSA. Magnesium 47-56 kallikrein related peptidase 3 Homo sapiens 116-119 15661661-11 2005 These results suggest that hOgg1 mainly operates as a monofunctional glycosylase under physiological concentrations of magnesium. Magnesium 119-128 8-oxoguanine DNA glycosylase Homo sapiens 27-32 15762675-1 2005 The availability of mannuronan and mannuronan C-5 epimerases allows the production of a strictly alternating mannuronate-guluronate (MG) polymer and the MG-enrichment of natural alginates, providing a powerful tool for the analysis of the role of such sequences in the calcium-alginate gel network. Magnesium 133-135 complement C5 Homo sapiens 46-49 15852743-1 2005 OBJECTIVE: To evaluate the effect of cyclosporine (CSA) on serum magnesium and its fractional excretion in renal transplant recipients. Magnesium 65-74 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 51-54 15852743-12 2005 CONCLUSION: CSA therapy lowers serum magnesium as compared to healthy controls and there is marked increase in FEMg% in 50% of the patients. Magnesium 37-46 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 12-15 15900896-3 2005 Similarly, the milk from cows with the clinical form of the disease showed a significant increase in sodium (P < 0.001) and a significant decrease in potassium, magnesium (P < 0.001) and calcium (P < 0.01). Magnesium 164-173 Weaning weight-maternal milk Bos taurus 15-19 15900896-5 2005 Comparison of healthy cow"s milk with that of clinically mastitic milk showed a highly significant decrease in levels of calcium, magnesium (P < 0.001) and potassium (P < 0.01). Magnesium 130-139 Weaning weight-maternal milk Bos taurus 28-32 15945613-9 2005 The quality of magnesium status directly influences the Biological Clock (BC) function, represented by the suprachiasmatic nuclei and the pineal gland. Magnesium 15-24 keratin 88, pseudogene Homo sapiens 74-76 15945613-13 2005 The differenciation between Mg depletion forms with hyperfunction of BC (HBC) and forms with hypofunction of BC (hBC) is seminal and the main biological marker is melatonin (MT) production alteration. Magnesium 28-30 keratin 88, pseudogene Homo sapiens 69-71 15945613-13 2005 The differenciation between Mg depletion forms with hyperfunction of BC (HBC) and forms with hypofunction of BC (hBC) is seminal and the main biological marker is melatonin (MT) production alteration. Magnesium 28-30 keratin 88, pseudogene Homo sapiens 73-76 15945613-13 2005 The differenciation between Mg depletion forms with hyperfunction of BC (HBC) and forms with hypofunction of BC (hBC) is seminal and the main biological marker is melatonin (MT) production alteration. Magnesium 28-30 keratin 88, pseudogene Homo sapiens 74-76 15945613-14 2005 We hypothesize that magnesium depletion with HBC or hBC may be involved in chronopathological forms of asthma. Magnesium 20-29 keratin 88, pseudogene Homo sapiens 45-48 15945613-14 2005 We hypothesize that magnesium depletion with HBC or hBC may be involved in chronopathological forms of asthma. Magnesium 20-29 keratin 88, pseudogene Homo sapiens 52-55 15550676-0 2005 Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium. Magnesium 139-148 cytidine/uridine monophosphate kinase 1 Homo sapiens 85-99 15550676-6 2005 Free magnesium enhanced dCMPK activity but inhibited CMPK activity. Magnesium 5-14 cytidine/uridine monophosphate kinase 1 Homo sapiens 25-29 15550676-7 2005 Free ATP or excess ATP/magnesium, on the other hand, inhibited dCMPK but not CMPK reactions. Magnesium 23-32 cytidine/uridine monophosphate kinase 1 Homo sapiens 64-68 15550676-8 2005 The differential regulation of dCMPK versus CMPK activities by ATP or magnesium was also seen in other 2"-deoxypyrimidine analog monophosphates (deoxyuridine monophosphate, 5-fluorodeoxyuridine monophosphate, 1-beta-D-arabinofuranosylcytosine monophosphate, and gemcitabine monophosphate) versus their ribose-counterparts (UMP and 5-fluorouridine monophosphate), in a similar manner. Magnesium 70-79 cytidine/uridine monophosphate kinase 1 Homo sapiens 32-36 15579901-0 2005 Magnesium regulates ADP dissociation from myosin V. Magnesium 0-9 myosin VA Homo sapiens 42-50 15579901-4 2005 We have addressed this issue by examining how magnesium regulates the kinetics of ADP release from myosin V and actomyosin V. Our data support a model in which actin accelerates the release of ADP from myosin V by reducing the magnesium affinity of a myosin V-MgADP intermediate. Magnesium 46-55 myosin VA Homo sapiens 99-107 15579901-4 2005 We have addressed this issue by examining how magnesium regulates the kinetics of ADP release from myosin V and actomyosin V. Our data support a model in which actin accelerates the release of ADP from myosin V by reducing the magnesium affinity of a myosin V-MgADP intermediate. Magnesium 46-55 myosin heavy chain 14 Homo sapiens 99-105 15644200-0 2005 Ape1 abasic endonuclease activity is regulated by magnesium and potassium concentrations and is robust on alternative DNA structures. Magnesium 50-59 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 0-4 15655527-6 2005 The inhibition of the open NMDA receptor by external Mg(2+) and 5-HT was not additive, suggesting competition between Mg(2+) and 5-HT for a binding site in the NMDA receptor channel. Magnesium 53-55 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 27-40 15655527-6 2005 The inhibition of the open NMDA receptor by external Mg(2+) and 5-HT was not additive, suggesting competition between Mg(2+) and 5-HT for a binding site in the NMDA receptor channel. Magnesium 53-55 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 160-173 15692152-2 2005 Basic studies revealed the mechanism that magnesium deficiency may decrease ATPase, leading to increase in intracellular calcium of blood vessels, and then the vasoconstriction occurs in cardiovascular system. Magnesium 42-51 dynein axonemal heavy chain 8 Homo sapiens 76-82 15692157-6 2005 Magnesium plays a role in more than 300 enzymatic reactions and is critically involved in energy metabolism, glucose utilization, protein synthesis, fatty acid synthesis and breakdown, ATPase functions, and virtually all hormonal reactions. Magnesium 0-9 dynein axonemal heavy chain 8 Homo sapiens 185-191 15692160-2 2005 Accumulating findings have revealed that magnesium deficiency relates cardiovascular risk factors including elevated blood pressure, insulin resistance, dyslipidemia, platelet aggregation, and inflammatory reaction, and leads to atherosclerosis. Magnesium 41-50 insulin Homo sapiens 133-140 15692165-1 2005 Recently, there are some reports about correlations between insulin resistance and deficiency of magnesium. Magnesium 97-106 insulin Homo sapiens 60-67 15692165-3 2005 It is expected that the exact mechanisms between insulin resistance, metabolic syndrome and magnesium metabolism. Magnesium 92-101 insulin Homo sapiens 49-56 15243721-0 2005 Effects of intracellular magnesium on Kv1.5 and Kv2.1 potassium channels. Magnesium 25-34 potassium voltage-gated channel subfamily A member 4 L homeolog Xenopus laevis 38-43 15243721-0 2005 Effects of intracellular magnesium on Kv1.5 and Kv2.1 potassium channels. Magnesium 25-34 potassium channel, voltage gated Shab related subfamily B, member 1 S homeolog Xenopus laevis 48-53 15689218-0 2005 Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin. Magnesium 13-22 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 33-36 15689218-11 2005 We suggest that the favorable effects of bathing in the Dead Sea salt solution are most likely related to the high magnesium content. Magnesium 115-124 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 61-64 15662226-0 2005 Magnesium supplementation prevents angiotensin II-induced myocardial damage and CTGF overexpression. Magnesium 0-9 angiotensinogen Rattus norvegicus 35-49 15662226-0 2005 Magnesium supplementation prevents angiotensin II-induced myocardial damage and CTGF overexpression. Magnesium 0-9 cellular communication network factor 2 Rattus norvegicus 80-84 15662226-2 2005 Recent studies provide evidence that Ang II mobilizes intracellular Mg through AT1 receptor-mediated pathways. Magnesium 68-70 angiotensinogen Rattus norvegicus 37-43 15662226-2 2005 Recent studies provide evidence that Ang II mobilizes intracellular Mg through AT1 receptor-mediated pathways. Magnesium 68-70 angiotensin II receptor, type 1a Rattus norvegicus 79-82 15662226-3 2005 We tested the hypothesis of whether magnesium supplementation prevents Ang II-induced myocardial damage and induction of the profibrotic connective tissue growth factor (CTGF). Magnesium 36-45 angiotensinogen Rattus norvegicus 71-77 15662226-3 2005 We tested the hypothesis of whether magnesium supplementation prevents Ang II-induced myocardial damage and induction of the profibrotic connective tissue growth factor (CTGF). Magnesium 36-45 cellular communication network factor 2 Rattus norvegicus 137-168 15662226-3 2005 We tested the hypothesis of whether magnesium supplementation prevents Ang II-induced myocardial damage and induction of the profibrotic connective tissue growth factor (CTGF). Magnesium 36-45 cellular communication network factor 2 Rattus norvegicus 170-174 15662226-7 2005 RESULTS: Magnesium (Mg) supplementation decreased blood pressure, ameliorated cardiac hypertrophy, protected against the development of Ang II-induced myocardial damage and increased serum ionized Mg2+ concentration (all variables P < 0.05). Magnesium 9-18 angiogenin Rattus norvegicus 136-139 15662226-7 2005 RESULTS: Magnesium (Mg) supplementation decreased blood pressure, ameliorated cardiac hypertrophy, protected against the development of Ang II-induced myocardial damage and increased serum ionized Mg2+ concentration (all variables P < 0.05). Magnesium 20-22 angiogenin Rattus norvegicus 136-139 15662226-10 2005 Magnesium supplementation prevented Ang II-induced myocardial CTGF overexpression (P < 0.05). Magnesium 0-9 angiotensinogen Rattus norvegicus 36-42 15662226-10 2005 Magnesium supplementation prevented Ang II-induced myocardial CTGF overexpression (P < 0.05). Magnesium 0-9 cellular communication network factor 2 Rattus norvegicus 62-66 15662226-12 2005 CONCLUSION: Our findings suggest a salutary effect for magnesium supplementation in the treatment of Ang II-induced myocardial complications. Magnesium 55-64 angiogenin Rattus norvegicus 101-104 16060293-0 2005 Spin biochemistry: intramitochondrial nucleotide phosphorylation is a magnesium nuclear spin controlled process. Magnesium 70-79 spindlin 1 Homo sapiens 0-4 16060293-0 2005 Spin biochemistry: intramitochondrial nucleotide phosphorylation is a magnesium nuclear spin controlled process. Magnesium 70-79 spindlin 1 Homo sapiens 88-92 15654740-0 2005 Calcium and magnesium binding to human centrin 3 and interaction with target peptides. Magnesium 12-21 centrin 3 Homo sapiens 39-48 18969790-7 2005 The procedure was applied to the determination of magnesium in different types of waters (tap, well and mineral) validating the results against a reference procedure. Magnesium 50-59 nuclear RNA export factor 1 Homo sapiens 90-93 15628853-4 2005 Indeed, it has been proposed that, as opposed to other TMPKs, catalysis by TMPK(Mtub) necessitates the transient binding of a magnesium ion coordinating the phosphate acceptor. Magnesium 126-135 deoxythymidylate kinase Homo sapiens 55-59 15579901-4 2005 We have addressed this issue by examining how magnesium regulates the kinetics of ADP release from myosin V and actomyosin V. Our data support a model in which actin accelerates the release of ADP from myosin V by reducing the magnesium affinity of a myosin V-MgADP intermediate. Magnesium 46-55 myosin VA Homo sapiens 116-124 16351507-5 2005 IGF-1 was positively associated with magnesium in both black and white men (P = 0.008 and 0.05, respectively). Magnesium 37-46 insulin like growth factor 1 Homo sapiens 0-5 15353477-1 2005 Erythrocyte magnesium (Mg2+) deficiency has been demonstrated in sickle cell disease to contribute to erythrocyte dehydration, K loss, and thus sickling. Magnesium 12-21 mucin 7, secreted Homo sapiens 23-26 15668496-9 2005 IGF-I was positively associated with intakes of protein, magnesium, zinc, calcium, potassium, and phosphorus, and IGFBP-3 was positively associated with energy. Magnesium 57-66 insulin like growth factor 1 Homo sapiens 0-5 15617878-0 2005 Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist. Magnesium 0-9 insulin Homo sapiens 62-69 15617878-4 2005 Magnesium is a likely candidate in this regard; magnesium deficiency promotes insulin resistance in rodents and in humans, whereas supplemental magnesium has been found to prevent type 2 diabetes in rodent models of this syndrome, and to improve the insulin sensitivity of elderly or diabetic humans. Magnesium 0-9 insulin Homo sapiens 78-85 15617878-4 2005 Magnesium is a likely candidate in this regard; magnesium deficiency promotes insulin resistance in rodents and in humans, whereas supplemental magnesium has been found to prevent type 2 diabetes in rodent models of this syndrome, and to improve the insulin sensitivity of elderly or diabetic humans. Magnesium 0-9 insulin Homo sapiens 250-257 15617878-4 2005 Magnesium is a likely candidate in this regard; magnesium deficiency promotes insulin resistance in rodents and in humans, whereas supplemental magnesium has been found to prevent type 2 diabetes in rodent models of this syndrome, and to improve the insulin sensitivity of elderly or diabetic humans. Magnesium 144-153 insulin Homo sapiens 250-257 15617878-5 2005 Magnesium-rich diets as well as above-average serum magnesium are associated with reduced diabetes risk in prospective epidemiology, and with greater insulin sensitivity in cross-sectional studies; moreover, other types of magnesium-rich foods--dairy products, legumes, and nuts--have been linked to decreased diabetes risk in prospective studies. Magnesium 0-9 insulin Homo sapiens 150-157 15617878-6 2005 The biochemical role of magnesium in support of insulin function is still poorly understood. Magnesium 24-33 insulin Homo sapiens 48-55 15617878-7 2005 In light of evidence that magnesium can function as a mild natural calcium antagonist, it is interesting to note suggestive evidence that increases in intracellular free calcium may compromise the insulin responsiveness of adipocytes and skeletal muscle, and may indeed play a pathogenic role in the insulin resistance syndrome. Magnesium 26-35 insulin Homo sapiens 197-204 15617878-8 2005 Thus, it is proposed that some or all of the favorable impact of good magnesium status on insulin function may reflect antagonism of the induction or effects of increased intracellular free calcium. Magnesium 70-79 insulin Homo sapiens 90-97 16381743-0 2005 On the roles of the dopants in LiF: Mg,Cu,Na,Si thermoluminescent material. Magnesium 36-38 LIF interleukin 6 family cytokine Homo sapiens 31-34 16381743-3 2005 In case of LiF:Mg,Cu,Na,Si TL material, there are a few studies on the roles of the dopants. Magnesium 15-17 LIF interleukin 6 family cytokine Homo sapiens 11-14 15990413-0 2005 Treatment with magnesium improves reference memory but not working memory while reducing GFAP expression following traumatic brain injury. Magnesium 15-24 glial fibrillary acidic protein Rattus norvegicus 89-93 15485879-2 2004 It has been shown that TRPM7 plays a key role in the regulation of intracellular magnesium homeostasis as well as in anoxic neuronal death. Magnesium 81-90 transient receptor potential cation channel subfamily M member 7 Homo sapiens 23-28 15574250-4 2004 The illness is due to a defect in the reabsorption of magnesium and calcium at the thick ascending limb of Henle because of a mutation of the PCLN-1 gene, which encodes a protein, paracellin-1, which intervenes in the reabsorption of both cations. Magnesium 54-63 claudin 16 Homo sapiens 142-148 15574250-4 2004 The illness is due to a defect in the reabsorption of magnesium and calcium at the thick ascending limb of Henle because of a mutation of the PCLN-1 gene, which encodes a protein, paracellin-1, which intervenes in the reabsorption of both cations. Magnesium 54-63 claudin 16 Homo sapiens 180-192 16351507-7 2005 In black men, IGFBP-3 was positively associated with magnesium (P = 0.02), and one serving of milk per day was associated with an 8.23-ng/ml higher IGF-1 concentration (P = 0.05). Magnesium 53-62 insulin like growth factor binding protein 3 Homo sapiens 14-21 15578958-2 2004 The structural and functional studies of the first identified CLP, factor IX/factor X-binding protein, have led to an understanding how new functionally heterodimeric CLPs from monomeric C-type lectin related proteins may have evolved by 3D domain swapping, and have contributed to our understanding of the significance of magnesium ions in the blood coagulation cascade reaction. Magnesium 323-332 cysteine and glycine rich protein 3 Homo sapiens 62-65 15671919-7 2004 Preserving cellular potassium and magnesium pools by blocking the aldosterone effects could also improve both cellular insulin action and insulin secretion. Magnesium 34-43 insulin Homo sapiens 119-126 15637223-2 2004 measurement of magnesium [Mg2+]i has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism. Magnesium 15-24 mucin 7, secreted Homo sapiens 26-29 15637223-2 2004 measurement of magnesium [Mg2+]i has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism. Magnesium 146-155 mucin 7, secreted Homo sapiens 26-29 15637232-3 2004 In this paper, we show positive correlations between intake of Mg and balances of both Ca and P. METHODS AND RESULTS: Using these correlations, the mean value and upper limit of the 95% confidence interval (from the regression equation between Mg intake and either the balances of Ca or that of P, when each balance is equal to zero) were 4.584 and 4.802 (against Ca balance), 4.554 and 4.785 (against P balance) mg/kg BW/d, respectively. Magnesium 63-65 SMU1 DNA replication regulator and spliceosomal factor Homo sapiens 419-423 15726907-4 2004 The aim of this study is to analyze the clinical forms of Mg depletion with hypofunction of the Biological Clock (hBC). Magnesium 58-60 keratin 88, pseudogene Homo sapiens 114-117 15726907-8 2004 The clinical forms of NHE due to Mg depletion with hBC are central and peripheral. Magnesium 33-35 keratin 88, pseudogene Homo sapiens 51-54 15726907-11 2004 Three chronopathological forms of Mg depletion with hBC have been highlighted: 1. Magnesium 34-36 keratin 88, pseudogene Homo sapiens 52-55 15726907-19 2004 MS may be associated with primary disorders of BC Clinical forms of Mg depletion with hBC in MS present diurnal exacerbations and relapses during fair seasons. Magnesium 68-70 keratin 88, pseudogene Homo sapiens 47-49 15726907-19 2004 MS may be associated with primary disorders of BC Clinical forms of Mg depletion with hBC in MS present diurnal exacerbations and relapses during fair seasons. Magnesium 68-70 keratin 88, pseudogene Homo sapiens 86-89 15726907-21 2004 Comorbidities with anxiety and migraine are frequent.hBC may be treated by using darkness therapy with a balanced Mg status. Magnesium 114-116 keratin 88, pseudogene Homo sapiens 53-56 15562397-1 2004 Magnesium (Mg(2+)) has an important role in insulin action, and insulin stimulates Mg(2+) uptake in insulin-sensitive tissues. Magnesium 0-9 insulin Homo sapiens 44-51 15547137-11 2004 The new, artificial tertiary stabilized hRz are thus nearly independent of sequence context and enable for the first time the use of highly active hRz targeting almost any mRNA at physiologically relevant magnesium concentrations. Magnesium 205-214 TYS Homo sapiens 40-43 15547137-11 2004 The new, artificial tertiary stabilized hRz are thus nearly independent of sequence context and enable for the first time the use of highly active hRz targeting almost any mRNA at physiologically relevant magnesium concentrations. Magnesium 205-214 TYS Homo sapiens 147-150 15549801-4 2004 The synthesis of siloxanes via organolithium and magnesium reagents was limited by the formation of di- and triarylated silanes (Ar(2)Si(OR)(2) and Ar(3)SiOR, respectively) and dehalogenated (Ar-H) byproducts. Magnesium 49-58 low density lipoprotein receptor adaptor protein 1 Homo sapiens 192-196 15797443-7 2005 Almost 10(5) externally bound divalent cations are displaced from membranes for every attached insulin molecule, implying a conformational membrane change that releases enough Mg(2+) from the internal surface of the plasma membrane to account for the increase in free cytosolic Mg(2+). Magnesium 176-178 insulin Homo sapiens 95-102 15797443-7 2005 Almost 10(5) externally bound divalent cations are displaced from membranes for every attached insulin molecule, implying a conformational membrane change that releases enough Mg(2+) from the internal surface of the plasma membrane to account for the increase in free cytosolic Mg(2+). Magnesium 278-280 insulin Homo sapiens 95-102 15797443-8 2005 It is proposed that mTOR, the central control point for protein synthesis of the PI 3-K kinase cascade stimulated by insulin, is regulated by MgATP(2-) which varies directly with cytosolic Mg(2+). Magnesium 142-144 mechanistic target of rapamycin kinase Homo sapiens 20-24 15797443-8 2005 It is proposed that mTOR, the central control point for protein synthesis of the PI 3-K kinase cascade stimulated by insulin, is regulated by MgATP(2-) which varies directly with cytosolic Mg(2+). Magnesium 142-144 insulin Homo sapiens 117-124 15535965-4 2004 This was followed, however, only in the liver of the Mg-deficient animals, by an increase in both alpha 2-macroglobulin (alpha-2m), an acute phase marker, and interleukin-6 transcripts suggesting that an inflammatory response had been initiated. Magnesium 53-55 alpha-2-macroglobulin Mus musculus 98-119 15535965-4 2004 This was followed, however, only in the liver of the Mg-deficient animals, by an increase in both alpha 2-macroglobulin (alpha-2m), an acute phase marker, and interleukin-6 transcripts suggesting that an inflammatory response had been initiated. Magnesium 53-55 alpha-2-macroglobulin Mus musculus 121-129 15535965-4 2004 This was followed, however, only in the liver of the Mg-deficient animals, by an increase in both alpha 2-macroglobulin (alpha-2m), an acute phase marker, and interleukin-6 transcripts suggesting that an inflammatory response had been initiated. Magnesium 53-55 interleukin 6 Mus musculus 159-172 15600832-2 2004 Upon excitation to the lowest three excited states of Mg+-ICH3, originating from the Mg+2P states, fragment ions of MgI+ and ICH+3 are found to have clear and different angular dependences, which are also characteristic of the excited states. Magnesium 54-57 caspase 5 Homo sapiens 58-62 15600832-2 2004 Upon excitation to the lowest three excited states of Mg+-ICH3, originating from the Mg+2P states, fragment ions of MgI+ and ICH+3 are found to have clear and different angular dependences, which are also characteristic of the excited states. Magnesium 54-57 caspase 5 Homo sapiens 125-130 15466192-10 2004 Patch-clamp recordings showed typical EAG-mediated currents modulated by magnesium and displaying a pronounced Cole-Moore shift. Magnesium 73-82 potassium voltage-gated channel subfamily H member 1 Homo sapiens 38-41 15459332-6 2004 Thermal denaturation monitored with CD and FTIR for cyt c at neutral pH but denatured with SDS showed that at a high SDS/protein ratio, the thermal behavior of MG-like states formed at low and neutral pH are quite similar. Magnesium 160-162 cytochrome c, somatic Equus caballus 52-57 15385461-6 2004 In conditions of low magnesium, the relA gene enhanced production of the cell-cell signal N-[3-oxododecanoyl]-l-homoserine lactone, whereas relA reduced the production of the 2-heptyl-3-hydroxy-4-quinolone signal during serine hydroxamate induction of the stringent response. Magnesium 21-30 Relish Drosophila melanogaster 36-40 15364583-5 2004 The X-ray structure of the C.jejuni dUTPase in complex with the non-hydrolysable substrate analogue dUpNHp allows us to define the positions of three catalytically significant phosphate-binding magnesium ions and provides a starting point for a detailed understanding of the mechanism of dUTP/dUDP hydrolysis by dimeric dUTPases. Magnesium 194-203 Deoxyuridine triphosphatase Drosophila melanogaster 36-43 15466953-11 2004 CONCLUSIONS: Both Mg deficit and obesity may independently lead to a higher risk for insulin resistance and cardiovascular disease. Magnesium 18-20 insulin Homo sapiens 85-92 15466955-8 2004 iNOS mRNA level was increased by LPS (0.1 microg/mL) and the increment was significantly high in Mg-deficient rat thoracic aorta. Magnesium 97-99 nitric oxide synthase 2 Rattus norvegicus 0-4 15218025-4 2004 DG2P1 and DG2P2 are magnesium-requiring enzymes and were inhibited by 10 and 100 microm of a cGK inhibitor, 8-(4-chlorophenylthio)guanosine-3",5"-cyclic monophosphorothioate, Rp isomer; whereas DG1, the cGK encoded by the D. melanogaster dg1 gene, was unaffected. Magnesium 20-29 Protein kinase, cGMP-dependent at 21D Drosophila melanogaster 194-197 15218025-4 2004 DG2P1 and DG2P2 are magnesium-requiring enzymes and were inhibited by 10 and 100 microm of a cGK inhibitor, 8-(4-chlorophenylthio)guanosine-3",5"-cyclic monophosphorothioate, Rp isomer; whereas DG1, the cGK encoded by the D. melanogaster dg1 gene, was unaffected. Magnesium 20-29 Protein kinase, cGMP-dependent at 21D Drosophila melanogaster 238-241 15350124-7 2004 While metal-dependent conformational changes are minimal, substitution of Mg(2+) for Ca(2+) is characterized by condensation of the C-terminal portion of the metal-binding loops with monodentate Mg(2+) ligation by the conserved Glu at position 12 and partial closure of the cTnI hydrophobic binding cleft around site IV. Magnesium 74-76 troponin I3, cardiac type Homo sapiens 274-278 15272039-0 2004 Magnesium-inhibited, TRPM6/7-like channel in cardiac myocytes: permeation of divalent cations and pH-mediated regulation. Magnesium 0-9 transient receptor potential cation channel, subfamily M, member 6 Rattus norvegicus 21-26 15724867-0 2004 Elevated concentrations of TNF-alpha are related to low serum magnesium levels in obese subjects. Magnesium 62-71 tumor necrosis factor Homo sapiens 27-36 15350215-2 2004 The structure of an archetypal member of this class, inositol 1,4,5-trisphosphate 3-kinase (IP3K), has been determined at 2.2 angstroms resolution in complex with magnesium and adenosine diphosphate. Magnesium 163-172 inositol-trisphosphate 3-kinase B Homo sapiens 53-90 15350215-2 2004 The structure of an archetypal member of this class, inositol 1,4,5-trisphosphate 3-kinase (IP3K), has been determined at 2.2 angstroms resolution in complex with magnesium and adenosine diphosphate. Magnesium 163-172 inositol-trisphosphate 3-kinase B Homo sapiens 92-96 15724867-1 2004 The aim of this study was to determine the relationship between serum magnesium and TNF-alpha levels in obese subjects. Magnesium 70-79 tumor necrosis factor Homo sapiens 84-93 15724867-7 2004 Multivariate OR between low serum magnesium and TNF-alpha levels in obese subjects was of 1.8, Cl95% 1.2-9.1, P = 0.001, whereas in the lean and overweight individuals of 1.1, Cl95% 0.7-8.7, P = 0.12, and 1.3, Cl95% 0.9-10.8, P = 0.09, respectively. Magnesium 34-43 tumor necrosis factor Homo sapiens 48-57 15724867-8 2004 These data shows that low serum magnesium levels and elevated TNF-alpha are related in the obese subjects. Magnesium 32-41 tumor necrosis factor Homo sapiens 62-71 15069188-1 2004 TRPM7 is a ubiquitously expressed and constitutively active divalent cation-selective ion channel, whose basal activity is regulated by intracellular levels of Mg(2+) and Mg.ATP. Magnesium 160-162 transient receptor potential cation channel subfamily M member 7 Homo sapiens 0-5 15323497-3 2004 The formation of mesophases could be related to the presence of anionic vanadium species, to the electrostatic interactions between the oppositely charged vanadates and micellar headgroups, and to the nature of the counterion of Mg2+ in the magnesium source. Magnesium 241-250 mucin 7, secreted Homo sapiens 229-232 15313013-7 2004 Interestingly, we demonstrated that the tumor cells could also adhere to immobilized fetuin-A in the presence of magnesium ions, and that this adhesion was most likely mediated by integrins because neutralizing antibodies against beta1 integrins substantially reduced the adhesion. Magnesium 113-122 alpha 2-HS glycoprotein Homo sapiens 85-93 15205455-8 2004 The regulatory N-domains of cardiac troponin C(F27W) and its mutants were also able to bind magnesium competitively and with physiologically relevant affinities (1.2-2.7 mm). Magnesium 92-101 troponin C1, slow skeletal and cardiac type Homo sapiens 28-46 15289101-3 2004 In the crystals the enzyme forms the asymmetric complex NSE x Mg2 x SO4/NSE x Mg x Cl, where "/" separates the dimer subunits. Magnesium 62-64 enolase 2 Homo sapiens 56-59 15289101-3 2004 In the crystals the enzyme forms the asymmetric complex NSE x Mg2 x SO4/NSE x Mg x Cl, where "/" separates the dimer subunits. Magnesium 62-64 enolase 2 Homo sapiens 72-75 15289101-4 2004 The subunit that contains the sulfate (or phosphate) ion and two magnesium ions is in the closed conformation observed in enolase complexes with the substrate or its analogues; the other subunit is in the open conformation observed in enolase subunits without bound substrate or analogues. Magnesium 65-74 enolase 2 Homo sapiens 122-129 15301552-3 2004 Here, we report (18)k(nuc) for phosphodiester hydrolysis catalyzed by Mg(2+) and by the Mg(2+)-dependent RNase P ribozyme and deamination by the Zn(2+)-dependent protein enzyme adenosine deaminase (ADA). Magnesium 70-72 adenosine deaminase Homo sapiens 177-196 15301552-3 2004 Here, we report (18)k(nuc) for phosphodiester hydrolysis catalyzed by Mg(2+) and by the Mg(2+)-dependent RNase P ribozyme and deamination by the Zn(2+)-dependent protein enzyme adenosine deaminase (ADA). Magnesium 70-72 adenosine deaminase Homo sapiens 198-201 15291623-3 2004 The vibrational frequencies, structures, and dipole moments of these complexes are found to vary dramatically with cluster size, illustrating the nonadditive nature of the HCN-magnesium interactions. Magnesium 176-185 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 172-175 15291623-4 2004 All of the complexes discussed here have the nitrogen end of the HCN pointing towards the magnesium clusters. Magnesium 90-99 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 65-68 15291623-6 2004 Although the HCN-Mg4 complex also has C3v symmetry, the HCN sits "on-top" of a single magnesium atom. Magnesium 86-95 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 13-16 15291623-6 2004 Although the HCN-Mg4 complex also has C3v symmetry, the HCN sits "on-top" of a single magnesium atom. Magnesium 86-95 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 56-59 15173182-4 2004 Large organic cations permeate through the activated TRPV1 pore even in the presence of physiological concentrations of Na(+), Mg(2+), and Ca(2+). Magnesium 127-129 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-58 15276840-1 2004 The structure of Mycobacterium tuberculosis dUTP nucleotidohydrolase (dUTPase) has been determined at 1.3 Angstrom resolution in complex with magnesium ion and the non-hydrolyzable substrate analog, alpha,beta-imido dUTP. Magnesium 142-151 Deoxyuridine triphosphatase Drosophila melanogaster 70-77 15372830-3 2004 Magnesium plays a role in more than 300 enzymatic reactions and is critically involved in energy metabolism, glucose utilization, protein synthesis, fatty acid synthesis and breakdown, ATPase functions, and virtually all hormonal reactions. Magnesium 0-9 dynein axonemal heavy chain 8 Homo sapiens 185-191 15039145-9 2004 The calcium content of the fetal skeleton was normal; however, total Mg content was reduced in Ct/Cgrp null skeletons obtained from Ct/Cgrp null mothers. Magnesium 69-71 calcitonin related polypeptide alpha Homo sapiens 98-102 15291819-0 2004 How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase. Magnesium 25-34 phosphoserine phosphatase Homo sapiens 58-83 15271519-5 2004 The loss of RNA-binding activity is due to the reversible and specific aggregation of the IRP1 apoprotein with zinc and cadmium, since precipitation did not occur with other divalent metals such as manganese, cobalt or magnesium. Magnesium 219-228 aconitase 1 Homo sapiens 90-94 15558947-3 2004 The data indicate that the inhibition of hK1 by sodium, potassium, calcium and magnesium is linear competitive and that divalent cations are more potent inhibitors of hK1 than univalent cations. Magnesium 79-88 keratin 1 Homo sapiens 41-44 15478804-6 2004 The diphosphatase activity was dependent on the presence of magnesium ions and a reducing agent, while the 5"-nucleotidase activity was enhanced by these additions. Magnesium 60-69 Tsp_06020 Trichinella spiralis 107-122 15280028-5 2004 The possible role of Gun4 for the Mg as well as Fe porphyrin biosynthesis branches in Synechocystis sp. Magnesium 34-36 protein GENOMES UNCOUPLED 4 Arabidopsis thaliana 21-25 15219851-0 2004 Characterization of calcium and magnesium binding domains of human 5-lipoxygenase. Magnesium 32-41 arachidonate 5-lipoxygenase Homo sapiens 67-81 15238001-0 2004 Critical role of magnesium ions in DNA polymerase beta"s closing and active site assembly. Magnesium 17-26 DNA polymerase beta Homo sapiens 35-54 15226506-6 2004 Our data demonstrate that, in the presence of Mg(2+), the hRad51-ATP-ssDNA filament is quickly converted to an inactive hRad51-ADP-ssDNA form, due to relatively rapid ATP hydrolysis and slow dissociation of ADP. Magnesium 46-48 RAD51 recombinase Homo sapiens 58-64 15150423-0 2004 TRPM7: channeling the future of cellular magnesium homeostasis? Magnesium 41-50 transient receptor potential cation channel subfamily M member 7 Homo sapiens 0-5 15150423-1 2004 A recent paper by Schmitz and colleagues provides persuasive evidence that the ion channel transient receptor potential melastatin 7 (TRPM7) may be the long-sought regulator of magnesium (Mg) homeostasis in mammalian cells. Magnesium 177-186 transient receptor potential cation channel subfamily M member 7 Homo sapiens 91-132 15150423-1 2004 A recent paper by Schmitz and colleagues provides persuasive evidence that the ion channel transient receptor potential melastatin 7 (TRPM7) may be the long-sought regulator of magnesium (Mg) homeostasis in mammalian cells. Magnesium 177-186 transient receptor potential cation channel subfamily M member 7 Homo sapiens 134-139 15150423-1 2004 A recent paper by Schmitz and colleagues provides persuasive evidence that the ion channel transient receptor potential melastatin 7 (TRPM7) may be the long-sought regulator of magnesium (Mg) homeostasis in mammalian cells. Magnesium 188-190 transient receptor potential cation channel subfamily M member 7 Homo sapiens 91-132 15150423-1 2004 A recent paper by Schmitz and colleagues provides persuasive evidence that the ion channel transient receptor potential melastatin 7 (TRPM7) may be the long-sought regulator of magnesium (Mg) homeostasis in mammalian cells. Magnesium 188-190 transient receptor potential cation channel subfamily M member 7 Homo sapiens 134-139 15150423-3 2004 However, these studies introduce an exciting new twist into our understanding of Mg homeostasis; TRPM7 facilitates Mg entry into the cell, whereas other putative Mg transporters apparently operate in the opposite direction. Magnesium 81-83 transient receptor potential cation channel subfamily M member 7 Homo sapiens 97-102 15150423-3 2004 However, these studies introduce an exciting new twist into our understanding of Mg homeostasis; TRPM7 facilitates Mg entry into the cell, whereas other putative Mg transporters apparently operate in the opposite direction. Magnesium 115-117 transient receptor potential cation channel subfamily M member 7 Homo sapiens 97-102 15165363-10 2004 Magnesium treatment resulted in a reduction in apoptosis and expression of p53-related proteins. Magnesium 0-9 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 75-78 15234103-1 2004 Magnesium-dependent neutral sphingomyelinase (N-SMase) present in plasma membranes is an enzyme that can be activated by stress in the form of inflammatory cytokines, serum deprivation, and hypoxia. Magnesium 0-9 sphingomyelin phosphodiesterase 2, neutral Mus musculus 20-44 15234103-1 2004 Magnesium-dependent neutral sphingomyelinase (N-SMase) present in plasma membranes is an enzyme that can be activated by stress in the form of inflammatory cytokines, serum deprivation, and hypoxia. Magnesium 0-9 sphingomyelin phosphodiesterase 2, neutral Mus musculus 46-53 15226506-6 2004 Our data demonstrate that, in the presence of Mg(2+), the hRad51-ATP-ssDNA filament is quickly converted to an inactive hRad51-ADP-ssDNA form, due to relatively rapid ATP hydrolysis and slow dissociation of ADP. Magnesium 46-48 RAD51 recombinase Homo sapiens 120-126 15221343-0 2004 Effects of magnesium on matrix metalloproteinase-2 production in cultured rat cardiac fibroblasts. Magnesium 11-20 matrix metallopeptidase 2 Rattus norvegicus 24-50 15221343-5 2004 Using gelatin zymography and western blotting, we found that magnesium reduced MMP-2 production dose-dependently, and this effect was inhibited by the tyrosine kinase inhibitors, genistein or herbimycin A. Magnesium 61-70 matrix metallopeptidase 2 Rattus norvegicus 79-84 15221343-6 2004 The results of this study indicated that the beneficial effect of magnesium supplementation on the cardiac disease may be due, at least in part, to the inhibitory effect of magnesium on production of MMPs in cardiac fibroblasts, which appears to be mediated by a protein tyrosine phosphorylation related signal transduction pathway. Magnesium 66-75 matrix metallopeptidase 2 Rattus norvegicus 200-204 15221343-6 2004 The results of this study indicated that the beneficial effect of magnesium supplementation on the cardiac disease may be due, at least in part, to the inhibitory effect of magnesium on production of MMPs in cardiac fibroblasts, which appears to be mediated by a protein tyrosine phosphorylation related signal transduction pathway. Magnesium 173-182 matrix metallopeptidase 2 Rattus norvegicus 200-204 15075348-7 2004 The cytotoxicity/apoptotic effect of human S100A8/A9 and DTPA was inhibited significantly (P<0.05) by Zn(+2) and Cu(+2), more effectively than by Ca(2+) and Mg(2+). Magnesium 160-162 S100 calcium binding protein A8 Homo sapiens 43-49 15211157-0 2004 Small physiologic changes in calcium and magnesium alter excitability and burst firing of CA1 pyramidal cells in rat hippocampal slices. Magnesium 41-50 carbonic anhydrase 1 Rattus norvegicus 90-93 15532719-7 2004 These data indicate the occurrence of a major alteration in Mg2+ transport across the hepatocyte membrane, which can explain, at least in part, the decrease in liver magnesium content observed in diabetic animals and patients. Magnesium 166-175 mucin 7, secreted Homo sapiens 60-63 15384920-2 2004 The improved insulin sensitivity may be mediated in part by magnesium and dietary fiber, two nutrients found in whole-grain foods. Magnesium 60-69 insulin Homo sapiens 13-20 15229293-5 2004 The dsDNA preference of hABH2 was observed only in the presence of magnesium. Magnesium 67-76 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Homo sapiens 24-29 15196914-2 2004 The crystal structure of Rab9 complexed to GDP, Mg(2+), and Sr(2+) reveals a unique dimer formed by an intermolecular beta-sheet that buries the switch I regions. Magnesium 48-50 RAB9A, member RAS oncogene family Homo sapiens 25-29 15157096-0 2004 The crystal structure of Sulfolobus solfataricus elongation factor 1alpha in complex with magnesium and GDP. Magnesium 90-99 Hsp20/alpha crystallin family protein Saccharolobus solfataricus 49-73 15157096-3 2004 To further investigate the role that magnesium plays in the exchange process of EF-1alpha and to check the ability of SsEF-1alpha.GDP to bind the ion, we have determined the crystal structure of SsEF-1alpha.GDP in the presence of a nonphysiological concentration (100 mM) of Mg(2+). Magnesium 37-46 ribosomal protein S18-alanine N-acetyltransferase Saccharolobus solfataricus 80-89 15157096-3 2004 To further investigate the role that magnesium plays in the exchange process of EF-1alpha and to check the ability of SsEF-1alpha.GDP to bind the ion, we have determined the crystal structure of SsEF-1alpha.GDP in the presence of a nonphysiological concentration (100 mM) of Mg(2+). Magnesium 37-46 ribosomal protein S18-alanine N-acetyltransferase Saccharolobus solfataricus 195-206 15269538-1 2004 Inductively coupled plasma analysis of soybean Bowman-Birk inhibitor (BBI) indicated that BBI was a metalloprotein which contained magnesium, calcium, and zinc at 0.40, 0.43 and 0.008 atom/mol BBI, respectively. Magnesium 131-140 Bowman-Birk type proteinase inhibitor Glycine max 90-93 15269538-1 2004 Inductively coupled plasma analysis of soybean Bowman-Birk inhibitor (BBI) indicated that BBI was a metalloprotein which contained magnesium, calcium, and zinc at 0.40, 0.43 and 0.008 atom/mol BBI, respectively. Magnesium 131-140 Bowman-Birk type proteinase inhibitor Glycine max 90-93 15223977-0 2004 Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. Magnesium 5-14 insulin Homo sapiens 40-47 15223977-0 2004 Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. Magnesium 5-14 insulin Homo sapiens 90-97 15223977-3 2004 Our purpose was to determine whether oral magnesium supplementation with magnesium chloride (MgCl2) 2.5 g daily modify insulin sensitivity in non-diabetic subjects. Magnesium 42-51 insulin Homo sapiens 119-126 15223977-9 2004 CONCLUSIONS: Oral magnesium supplementation improves insulin sensitivity in hypomagnesemic non-diabetic subjects. Magnesium 18-27 insulin Homo sapiens 53-60 15224132-4 2004 Crystal structure analysis of PDE4"s catalytic domain identifies two metal-binding sites: a high-affinity site and a low-affinity site, which probably bind zinc (Zn2+) and magnesium (Mg2+), respectively. Magnesium 172-181 phosphodiesterase 4A Homo sapiens 30-34 15095290-10 2004 WT significantly blocked the insulin-stimulated Na(+)/Mg(2+) activity (n = 6, P = 0.048), with an IC(50) of 0.5 nmol/L. Magnesium 54-56 insulin Homo sapiens 29-36 15232810-11 2004 MEASUREMENTS AND MAIN RESULTS: A total of 147 patients could be evaluated: in the magnesium-treated group (n = 74), 25 patients developed POAT (34%) and in the placebo group (n = 73) 19 patients (26%) (p = 0.36). Magnesium 82-91 solute carrier organic anion transporter family member 4A1 Homo sapiens 138-142 15319146-2 2004 Magnesium has an important role in insulin action, and insulin stimulates magnesium uptake in insulin-sensitive tissues. Magnesium 0-9 insulin Homo sapiens 35-42 15319146-2 2004 Magnesium has an important role in insulin action, and insulin stimulates magnesium uptake in insulin-sensitive tissues. Magnesium 74-83 insulin Homo sapiens 55-62 15319146-2 2004 Magnesium has an important role in insulin action, and insulin stimulates magnesium uptake in insulin-sensitive tissues. Magnesium 74-83 insulin Homo sapiens 55-62 15319146-4 2004 This review was designed to reach a better understanding of the mechanism involved in the correlation between magnesium and insulin resistance. Magnesium 110-119 insulin Homo sapiens 124-131 15319146-6 2004 In patients with type 2 diabetes an inverse association exists between the plasma magnesium and insulin resistance due to intracellular changes. Magnesium 82-91 insulin Homo sapiens 96-103 15319146-7 2004 The suppressed intracellular magnesium concentration may result in defective tyrosine kinase activity and modify insulin sensitivity by influencing receptor activity after binding or by influencing intracellular signaling and processing. Magnesium 29-38 insulin Homo sapiens 113-120 15319146-8 2004 Intracellular magnesium deficiency may affect the development of insulin resistance and alter the glucose entry into the cell. Magnesium 14-23 insulin Homo sapiens 65-72 15319146-9 2004 CONCLUSIONS: Magnesium is required for both proper glucose utilization and insulin signaling. Magnesium 13-22 insulin Homo sapiens 75-82 15319146-10 2004 Metabolic alterations in cellular magnesium, which may play the role of a second messenger for insulin action, contribute to insulin resistance. Magnesium 34-43 insulin Homo sapiens 95-102 15319146-10 2004 Metabolic alterations in cellular magnesium, which may play the role of a second messenger for insulin action, contribute to insulin resistance. Magnesium 34-43 insulin Homo sapiens 125-132 15158908-5 2004 In addition, we demonstrate that high concentrations of magnesium did not modulate the levels of plasminogen activator inhibitor-1, but enhanced the synthesis of nitric oxide, in part through the up-regulation of endothelial nitric oxide synthase. Magnesium 56-65 nitric oxide synthase 3 Homo sapiens 213-246 15158909-4 2004 We found that low Mg concentrations reversibly inhibit endothelial proliferation, and this event correlates with a marked down-regulation of the levels of CDC25B. Magnesium 18-20 cell division cycle 25B Homo sapiens 155-161 15134902-9 2004 In addition, because MG also induces the expression of B7-H1, it may enable macrophages to provide a concomitant downregulatory signal to T-lymphocytes expressing PD-1 or related receptors. Magnesium 21-23 CD274 antigen Mus musculus 55-60 15069188-1 2004 TRPM7 is a ubiquitously expressed and constitutively active divalent cation-selective ion channel, whose basal activity is regulated by intracellular levels of Mg(2+) and Mg.ATP. Magnesium 171-173 transient receptor potential cation channel subfamily M member 7 Homo sapiens 0-5 15050431-0 2004 ALS-like skin changes in mice on a chronic low-Ca/Mg high-Al diet. Magnesium 50-52 superoxide dismutase 1 Homo sapiens 0-3 15050431-1 2004 Epidemiologic studies of endemic foci of amyotrophic lateral sclerosis (ALS) have shown low concentrations of Ca/Mg and high concentrations of Al/Mn in the drinking water and garden soil, which may play a causative role in the pathogenesis of endemic ALS. Magnesium 113-115 superoxide dismutase 1 Homo sapiens 72-75 15050431-6 2004 We speculate that environmental factors such as chronic low-Ca/Mg high-Al condition play some causative role in the pathogenesis of Kii-ALS. Magnesium 63-65 superoxide dismutase 1 Homo sapiens 136-139 15001450-4 2004 In the past few years, the genetic disclosure of inborn errors of magnesium handling revealed several new proteins along with already known molecules unexpectedly involved in renal epithelial magnesium transport, e.g., paracellin-1, a key player in paracellular magnesium and calcium reabsorption in the thick ascending limb or the gamma-subunit of the Na(+)-K(+)-ATPase in the distal convoluted tubule. Magnesium 66-75 claudin 16 Homo sapiens 219-231 14988231-8 2004 These myocytes also released the CXC chemokines LIX and KC; an event prevented by MG 132. Magnesium 82-84 chemokine (C-X-C motif) ligand 5 Mus musculus 48-51 15001450-4 2004 In the past few years, the genetic disclosure of inborn errors of magnesium handling revealed several new proteins along with already known molecules unexpectedly involved in renal epithelial magnesium transport, e.g., paracellin-1, a key player in paracellular magnesium and calcium reabsorption in the thick ascending limb or the gamma-subunit of the Na(+)-K(+)-ATPase in the distal convoluted tubule. Magnesium 192-201 claudin 16 Homo sapiens 219-231 15001450-4 2004 In the past few years, the genetic disclosure of inborn errors of magnesium handling revealed several new proteins along with already known molecules unexpectedly involved in renal epithelial magnesium transport, e.g., paracellin-1, a key player in paracellular magnesium and calcium reabsorption in the thick ascending limb or the gamma-subunit of the Na(+)-K(+)-ATPase in the distal convoluted tubule. Magnesium 192-201 claudin 16 Homo sapiens 219-231 15001450-5 2004 In this review, we focus on TRPM6, an ion channel of the "transient receptor potential (TRP) gene family, which, when mutated, causes a combined defect of intestinal magnesium absorption and renal magnesium conservation as observed in primary hypomagnesemia with secondary hypocalcemia. Magnesium 166-175 transient receptor potential cation channel subfamily M member 6 Homo sapiens 28-33 15001450-5 2004 In this review, we focus on TRPM6, an ion channel of the "transient receptor potential (TRP) gene family, which, when mutated, causes a combined defect of intestinal magnesium absorption and renal magnesium conservation as observed in primary hypomagnesemia with secondary hypocalcemia. Magnesium 197-206 transient receptor potential cation channel subfamily M member 6 Homo sapiens 28-33 14992593-4 2004 Furthermore, we provide the first evidence for magnesium binding to CIB and determine the structural consequences of this interaction. Magnesium 47-56 calcium and integrin binding 1 Homo sapiens 68-71 14762707-12 2004 The complex stability orders for both1 and2 are Ca(II)<Mg(II)<Zn(II)<Cu(II). Magnesium 58-60 carbonic anhydrase 2 Homo sapiens 48-54 14762707-14 2004 On the other hand, the amino group in carbamoylphosphonic acid2 lowers the stability of the complexes with metals favoring oxygen ligands (Ca, Mg and Fe) and increases the selectivity towards Zn. Magnesium 143-145 PTOV1 extended AT-hook containing adaptor protein Homo sapiens 58-63 14643749-4 2004 The accumulation of ceramide was found to depend on the activation of magnesium-dependent neutral sphingomyelinase (N-SMase), but not on de novo synthesis. Magnesium 70-79 sphingomyelin phosphodiesterase 2 Rattus norvegicus 90-114 14643749-4 2004 The accumulation of ceramide was found to depend on the activation of magnesium-dependent neutral sphingomyelinase (N-SMase), but not on de novo synthesis. Magnesium 70-79 sphingomyelin phosphodiesterase 2 Rattus norvegicus 116-123 15125462-5 2004 The organ culture supernatants from H. pylori-positive patients induced the expression of intercellular adhesion molecule-1 mRNA in HUVEC with increased binding of neutrophils, and these stimulatory effects were inhibited when HUVEC were pretreated with a nuclear factor-kappaB inhibitor, MG-132. Magnesium 289-291 intercellular adhesion molecule 1 Homo sapiens 90-123 14992593-6 2004 Both calcium and magnesium binding induce conformational changes which stabilize both the secondary and tertiary structure of CIB, resulting in considerable increases in the thermal stability of the proteins. Magnesium 17-26 calcium and integrin binding 1 Homo sapiens 126-129 15493290-5 2004 The results of thermal analysis (DTA, DSC, TG) of magnesium complexes indicated their good thermal resistance up to the temperature of 375 K. Magnesium 50-59 desmocollin 3 Homo sapiens 38-41 15023352-0 2004 A kinetic approach towards understanding substrate interactions and the catalytic mechanism of the serine/threonine protein kinase ERK2: identifying a potential regulatory role for divalent magnesium. Magnesium 190-199 mitogen-activated protein kinase 1 Homo sapiens 131-135 15023352-6 2004 Here we review several steady-state kinetic experiments that reveal details of the ERK2 mechanism and a hitherto unknown process of ERK2 activation by free magnesium. Magnesium 156-165 mitogen-activated protein kinase 1 Homo sapiens 132-136 14976260-1 2004 Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. Magnesium 9-18 transient receptor potential cation channel subfamily M member 6 Homo sapiens 49-54 14976260-1 2004 Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. Magnesium 9-18 transient receptor potential cation channel subfamily M member 6 Homo sapiens 100-105 14976260-1 2004 Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. Magnesium 160-169 transient receptor potential cation channel subfamily M member 6 Homo sapiens 49-54 14976260-1 2004 Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. Magnesium 160-169 transient receptor potential cation channel subfamily M member 6 Homo sapiens 100-105 14976260-6 2004 Together, our data suggest an important contribution of TRPM6/TRPM7 heterooligomerization for the biological role of TRPM6 in epithelial magnesium absorption. Magnesium 137-146 transient receptor potential cation channel subfamily M member 6 Homo sapiens 56-61 14976260-6 2004 Together, our data suggest an important contribution of TRPM6/TRPM7 heterooligomerization for the biological role of TRPM6 in epithelial magnesium absorption. Magnesium 137-146 transient receptor potential cation channel subfamily M member 7 Homo sapiens 62-67 14976260-6 2004 Together, our data suggest an important contribution of TRPM6/TRPM7 heterooligomerization for the biological role of TRPM6 in epithelial magnesium absorption. Magnesium 137-146 transient receptor potential cation channel subfamily M member 6 Homo sapiens 117-122 14988352-2 2004 A short cut review was carried out to establish whether the addition of intravenous magnesium to standard treatments improved outcome in patients with exacerbations of COPD. Magnesium 84-93 COPD Homo sapiens 168-172 14645372-0 2004 Structural basis for the coordinated regulation of transglutaminase 3 by guanine nucleotides and calcium/magnesium. Magnesium 105-114 transglutaminase 3 Homo sapiens 51-69 15279159-0 2004 [Regulatory effect of magnesium ions on prolactin and somatotropin interaction with receptors of granulosa cells in Bos taurus]. Magnesium 22-31 prolactin Bos taurus 40-49 15279159-0 2004 [Regulatory effect of magnesium ions on prolactin and somatotropin interaction with receptors of granulosa cells in Bos taurus]. Magnesium 22-31 somatotropin Bos taurus 54-66 14763746-2 2004 This stationary phase, when used in conjunction with a 2 mM ethylenediamine and 0.1 mM Li-DS solution as eluent at pH 6.0, was found to be suitable for the rapid and efficient separation of hydrogen and magnesium and calcium in the order H+ < Mg2+ < Ca2+ within 4 min at a flow rate of 4.0 ml/min. Magnesium 203-212 mucin 7, secreted Homo sapiens 246-249 15223753-0 2004 Alterations in growth plate and articular cartilage morphology are associated with reduced SOX9 localization in the magnesium-deficient rat. Magnesium 116-125 SRY-box transcription factor 9 Rattus norvegicus 91-95 15223753-6 2004 Immunolocalization of Sox9 was decreased in both articular and growth plate cartilage in experimental animals compared to controls, suggesting that reduced Mg intake causes cartilage changes that may be secondary to reduced levels of the SOX9 transcription factor. Magnesium 156-158 SRY-box transcription factor 9 Rattus norvegicus 22-26 15223753-6 2004 Immunolocalization of Sox9 was decreased in both articular and growth plate cartilage in experimental animals compared to controls, suggesting that reduced Mg intake causes cartilage changes that may be secondary to reduced levels of the SOX9 transcription factor. Magnesium 156-158 SRY-box transcription factor 9 Rattus norvegicus 238-242 14747211-4 2004 It is abundant in nutrients such as magnesium, calcium, and protein, which have been associated with improved insulin sensitivity. Magnesium 36-45 insulin Homo sapiens 110-117 15228213-6 2004 The dietary intakes of Ca, Mg and P ranged from 4.83-23.58, 2.44-7.83 and 13.46-45.69 mg/ kg BW/d, respectively. Magnesium 27-29 SMU1 DNA replication regulator and spliceosomal factor Homo sapiens 93-97 14534286-6 2004 Participation of NMDA receptors in reduced magnesium-induced synaptic events was supported by the localization of the NR1 subunit of the NMDA receptor with the presynaptic vesicular protein synaptophysin. Magnesium 43-52 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 118-121 14534286-6 2004 Participation of NMDA receptors in reduced magnesium-induced synaptic events was supported by the localization of the NR1 subunit of the NMDA receptor with the presynaptic vesicular protein synaptophysin. Magnesium 43-52 synaptophysin Homo sapiens 190-203 14594813-3 2004 The TRPM7/ChaK1 channel has been characterized using electrophysiological techniques, and recent evidence suggests that it may play a key role in the regulation of magnesium homeostasis. Magnesium 164-173 transient receptor potential cation channel subfamily M member 7 Homo sapiens 4-9 14594813-3 2004 The TRPM7/ChaK1 channel has been characterized using electrophysiological techniques, and recent evidence suggests that it may play a key role in the regulation of magnesium homeostasis. Magnesium 164-173 transient receptor potential cation channel subfamily M member 7 Homo sapiens 10-15 15472402-8 2004 Pretreatment of Ti with calcium, or magnesium alone, or combined resulted in increased adsorption of mucin to Ti. Magnesium 36-45 LOC100508689 Homo sapiens 101-106 14731032-2 2004 The 1:4 compound is obtained with excess XeF(2) while the 1:2 compound is prepared from stoichiometric amounts of Mg(AsF(6))(2) and XeF(2). Magnesium 114-116 arylsulfatase F Homo sapiens 117-120 14731032-4 2004 The octahedral coordination sphere of Mg consists of one fluorine atom from each of the four XeF(2) molecules and two fluorine atoms from the two AsF(6) units. Magnesium 38-40 arylsulfatase F Homo sapiens 146-149 15630176-4 2004 Besides improvement of GI condition, dietary sc-FOS influences on calcium and magnesium absorption in the colon. Magnesium 78-87 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 48-51 15630176-5 2004 A major mineral absorption site is the small intestine, but the colon also works as a Ca and Mg absorption site with an aid of SCFAs made from sc-FOS. Magnesium 93-95 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 146-149 15268792-4 2004 Milk is a source of calcium, phosphorus, zinc, magnesium and vitamin B2 and B12. Magnesium 47-56 Weaning weight-maternal milk Bos taurus 0-4 14751580-13 2004 Moreover, bone magnesium increased with intact PTH levels. Magnesium 15-24 parathyroid hormone Homo sapiens 47-50 14751580-18 2004 Magnesium may be involved in the suppression of PTH secretion, lowering bone turnover thus leading to an increase in bone mineralization profile and microhardness in aplastic bone disorder. Magnesium 0-9 parathyroid hormone Homo sapiens 48-51 14717702-7 2004 These are the first data demonstrating that GCH recognizes Mg-free GTP and requires Zn2+ for its catalytic activity. Magnesium 59-61 GTP cyclohydrolase 1 Homo sapiens 44-47 14693967-0 2004 Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Magnesium 8-17 insulin Homo sapiens 47-54 14693967-4 2004 In a sample of 349 apparently healthy women from this study, we measured plasma fasting insulin levels to examine their relation to magnesium intake. Magnesium 132-141 insulin Homo sapiens 88-95 14693967-9 2004 Multivariate-adjusted geometric mean insulin levels for overweight women in the lowest quartile of magnesium intake was 53.5 compared with 41.5 pmol/l among those at the highest quartile (P = 0.03 for trend). Magnesium 99-108 insulin Homo sapiens 37-44 15122652-9 2004 The high-affinity triacsin C inhibition of both the mitochondrial and microsomal LACS forms was found to require a high concentration of free Mg(2+), with the EC(50) for inhibition being 3 mM free Mg(2+). Magnesium 142-144 acyl-CoA synthetase long chain family member 1 Homo sapiens 81-85 14704297-17 2004 These data demonstrated that a Mg intake of 10% of NR in rats causes bone loss that may be secondary to the increased release of substance P and TNF-alpha. Magnesium 31-33 tumor necrosis factor Rattus norvegicus 145-154 15120847-1 2004 Transient receptor potential-vanilloid type-1 (TRPV1) is a ligand-gated cation channel with preference for divalent cations, especially Ca(2+) (sequence of conductances: Ca(2+)>Mg(2+)>Na(+) approximately/= K(+) approximately/= Cs(+)). Magnesium 180-182 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-45 14704297-9 2004 At 2 mo, serum PTH was elevated in Mg-deficient rats but was significantly decreased at 6 mo in contrast to control rats in which PTH rose. Magnesium 35-37 parathyroid hormone Rattus norvegicus 15-18 15488650-4 2004 Once gut/blood brain barrier permeability is impaired, the increased uptake of Al, Fe, Sr, Ba, or Mn into the Mg/Ca depleted brain leads to rogue metal substitutions at the Mg/Ca vacated binding domains on various enzyme/proteoglycan groups, causing a broad ranging disruption in Mg/Ca dependent systems - such as the glutamine synthetase which prevents the accumulation of neurotoxic glutamate. Magnesium 110-112 glutamate-ammonia ligase Homo sapiens 318-338 15488650-4 2004 Once gut/blood brain barrier permeability is impaired, the increased uptake of Al, Fe, Sr, Ba, or Mn into the Mg/Ca depleted brain leads to rogue metal substitutions at the Mg/Ca vacated binding domains on various enzyme/proteoglycan groups, causing a broad ranging disruption in Mg/Ca dependent systems - such as the glutamine synthetase which prevents the accumulation of neurotoxic glutamate. Magnesium 173-175 glutamate-ammonia ligase Homo sapiens 318-338 15488650-4 2004 Once gut/blood brain barrier permeability is impaired, the increased uptake of Al, Fe, Sr, Ba, or Mn into the Mg/Ca depleted brain leads to rogue metal substitutions at the Mg/Ca vacated binding domains on various enzyme/proteoglycan groups, causing a broad ranging disruption in Mg/Ca dependent systems - such as the glutamine synthetase which prevents the accumulation of neurotoxic glutamate. Magnesium 173-175 glutamate-ammonia ligase Homo sapiens 318-338 15120847-1 2004 Transient receptor potential-vanilloid type-1 (TRPV1) is a ligand-gated cation channel with preference for divalent cations, especially Ca(2+) (sequence of conductances: Ca(2+)>Mg(2+)>Na(+) approximately/= K(+) approximately/= Cs(+)). Magnesium 180-182 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 15120847-7 2004 We conclude that TRPV1 conducts protons, in addition to Na(+), K(+), Mg(2+), and Ca(2+). Magnesium 69-71 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-22 14974608-0 2004 Developments in the synthesis of LiF:Mg,Cu,Na,Si TL material. Magnesium 37-39 LIF interleukin 6 family cytokine Homo sapiens 33-36 14974608-2 2004 It was found that the optimum concentrations of dopants for a pellet-type LiF:Mg,Cu,Na,Si TL detector were found to be Mg: 0.2 mol %, Cu: 0.05 mol %, Na: 0.9 mol%, and Si: 0.9 mol%. Magnesium 78-80 LIF interleukin 6 family cytokine Homo sapiens 74-77 14566962-12 2003 Phosphorylation of MEK1/2 and ERK1/2 was enhanced two to threefold in cells grown in 2 mmol/L Mg(2+). Magnesium 94-96 mitogen activated protein kinase kinase 1 Rattus norvegicus 19-25 14730510-7 2004 Impaired function of paracellin-1 leads specifically to urinary losses of magnesium and calcium, but because transcellular transport is intact these patients do not have hypokalemia or salt wasting. Magnesium 74-83 claudin 16 Homo sapiens 21-33 14628289-1 2003 Mutations in the gene coding for the renal tight junction protein claudin 16 cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis, an autosomal recessive disorder of renal Ca(2+) and Mg(2+) handling that progressively leads to chronic renal failure, with nephrolithiasis having been reported in heterozygous carriers. Magnesium 201-203 claudin 16 Homo sapiens 66-76 14684759-0 2003 The association between magnesium intake and fasting insulin concentration in healthy middle-aged women. Magnesium 24-33 insulin Homo sapiens 53-60 14684759-1 2003 OBJECTIVE: We assessed the association between magnesium intake and fasting insulin levels in a large cohort of women. Magnesium 47-56 insulin Homo sapiens 76-83 14684759-6 2003 RESULTS: After adjustment for age, body mass index (BMI), total energy, physical activity, hours per week spent sitting outside work, alcohol intake, smoking, and family history of diabetes, magnesium intake was inversely associated with fasting insulin concentration. Magnesium 191-200 insulin Homo sapiens 246-253 14684759-9 2003 CONCLUSION: Higher magnesium intake is associated with lower fasting insulin concentrations among women without diabetes. Magnesium 19-28 insulin Homo sapiens 69-76 14684759-10 2003 Because lower fasting insulin concentrations generally reflect greater insulin sensitivity, these findings provide a mechanism through which higher dietary magnesium intake may reduce the risk of developing type 2 diabetes mellitus. Magnesium 156-165 insulin Homo sapiens 22-29 14684759-10 2003 Because lower fasting insulin concentrations generally reflect greater insulin sensitivity, these findings provide a mechanism through which higher dietary magnesium intake may reduce the risk of developing type 2 diabetes mellitus. Magnesium 156-165 insulin Homo sapiens 71-78 14566962-12 2003 Phosphorylation of MEK1/2 and ERK1/2 was enhanced two to threefold in cells grown in 2 mmol/L Mg(2+). Magnesium 94-96 mitogen activated protein kinase 3 Rattus norvegicus 30-36 14500766-1 2003 Magnesium ions (Mg2+) play an important role in biochemical functions. Magnesium 0-9 mucin 7, secreted Homo sapiens 16-19 14586471-6 2003 The reduction reaction catalysed by sulphiredoxin requires ATP hydrolysis and magnesium, involving a conserved active-site cysteine residue which forms a transient disulphide linkage with Tsa1. Magnesium 78-87 thioredoxin peroxidase TSA1 Saccharomyces cerevisiae S288C 188-192 14661860-8 2003 Taken together, these results suggest that JNK/SAPK may be related to NO-induced apoptosis in MG-63 human osteoblasts. Magnesium 94-96 mitogen-activated protein kinase 8 Homo sapiens 43-51 14567689-12 2003 In addition, the model suggests that in the presence of saturating concentrations of both magnesium and substrates ERK2 subunits dissociate with a dissociation constant (K(d)) of 32 +/- 16 nM. Magnesium 90-99 mitogen-activated protein kinase 1 Homo sapiens 115-119 12917423-5 2003 All eight common NTPs and dNTPs were hydrolyzed by the SARS helicase in a magnesium-dependent reaction, stimulated by the presence of either single-stranded DNA or RNA. Magnesium 74-83 helicase for meiosis 1 Homo sapiens 60-68 14516743-3 2003 Endonuclease I is active in the presence of magnesium, manganese, iron (II) and cobalt (II) ions, weakly active in the presence of nickel, copper (II) and zinc ions, and completely inactive in the presence of calcium ions. Magnesium 44-53 endonuclease I Escherichia phage T7 0-14 13679239-6 2003 Endotoxemia for 6 h was associated with elevated serum interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha levels, and strong TNF receptor mRNA expression in the abdominal aortas, which were significantly greater in the Mg-deficient rats. Magnesium 229-231 tumor necrosis factor Rattus norvegicus 82-115 13679239-7 2003 Treatment of the thoracic aortas, isolated from control and Mg-deficient rats before endotoxic challenge, with IL-1beta or TNF-alpha for 6 h in vitro caused hyporeactivity to PE, but its severity did not differ significantly between the two groups. Magnesium 60-62 interleukin 1 beta Rattus norvegicus 111-119 13679239-7 2003 Treatment of the thoracic aortas, isolated from control and Mg-deficient rats before endotoxic challenge, with IL-1beta or TNF-alpha for 6 h in vitro caused hyporeactivity to PE, but its severity did not differ significantly between the two groups. Magnesium 60-62 tumor necrosis factor Rattus norvegicus 123-132 13679239-8 2003 These results suggest that high serum IL-1beta and TNF-alpha levels, and increased TNF receptor production in the vascular tissue, contribute to vascular hyporeactivity to PE in endotoxemia, and to its enhancement in Mg-deficient rats, via NO/cGMP signaling. Magnesium 217-219 interleukin 1 beta Rattus norvegicus 38-46 13679239-8 2003 These results suggest that high serum IL-1beta and TNF-alpha levels, and increased TNF receptor production in the vascular tissue, contribute to vascular hyporeactivity to PE in endotoxemia, and to its enhancement in Mg-deficient rats, via NO/cGMP signaling. Magnesium 217-219 tumor necrosis factor Rattus norvegicus 51-60 14989640-0 2003 Alterations in osteoclast morphology following osteoprotegerin administration in the magnesium-deficient mouse. Magnesium 85-94 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 47-62 14989640-5 2003 Surprisingly, Mg-depleted mice that received OPG in doses that inhibit osteoclastic bone resorption remained hypercalcemic. Magnesium 14-16 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 45-48 14636008-6 2003 CONCLUSION: MARS exchanges potassium, chloride, calcium, and magnesium by ultrafiltration; sodium by the albumin dialysis. Magnesium 61-70 methionyl-tRNA synthetase 1 Homo sapiens 12-16 14516451-0 2003 Storage of platelets in additive solutions: the effects of magnesium and potassium on the release of RANTES, beta-thromboglobulin, platelet factor 4 and interleukin-7, during storage. Magnesium 59-68 C-C motif chemokine ligand 5 Homo sapiens 101-107 12944025-1 2003 Proto-oncogene (c-fos, c-jun) and nuclear factor-kappa B (NF-kappaB) expression, as well as DNA synthesis, in aortic and cerebral vascular smooth muscle cells (VSMCs) were upregulated by a decrease in extracellular magnesium ions ([Mg2+]o). Magnesium 215-224 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 0-21 14592924-6 2003 This is encouraging in view of the potential use of mucosally administered recombinant AChR fragments for the treatment of MG in humans. Magnesium 123-125 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 87-91 12680712-1 2003 Previously, we reported that the ATPase activity of GroEL that requires potassium and magnesium was highly temperature dependent in the 25-60 degrees C range. Magnesium 86-95 dynein axonemal heavy chain 8 Homo sapiens 33-39 12680712-1 2003 Previously, we reported that the ATPase activity of GroEL that requires potassium and magnesium was highly temperature dependent in the 25-60 degrees C range. Magnesium 86-95 heat shock protein family D (Hsp60) member 1 Homo sapiens 52-57 12680712-3 2003 ATPase activities with manganese, cobalt, and nickel were 64%, 41%, and 29%, respectively, of the maximum activity (100%) when utilizing magnesium. Magnesium 137-146 dynein axonemal heavy chain 8 Homo sapiens 0-6 12680712-6 2003 Maximum exposure of hydrophobic surfaces on GroEL alone or in the presence of each of the monovalent cations was determined to occur at 65 degrees C. However, the maximum exposure of hydrophobic surfaces on GroEL in the presence of magnesium, manganese, cobalt or nickel was found to occur at 71 degrees C indicating that GroEL is significantly stabilized against thermal denaturation by these divalent cations. Magnesium 232-241 heat shock protein family D (Hsp60) member 1 Homo sapiens 44-49 12680712-6 2003 Maximum exposure of hydrophobic surfaces on GroEL alone or in the presence of each of the monovalent cations was determined to occur at 65 degrees C. However, the maximum exposure of hydrophobic surfaces on GroEL in the presence of magnesium, manganese, cobalt or nickel was found to occur at 71 degrees C indicating that GroEL is significantly stabilized against thermal denaturation by these divalent cations. Magnesium 232-241 heat shock protein family D (Hsp60) member 1 Homo sapiens 207-212 12680712-6 2003 Maximum exposure of hydrophobic surfaces on GroEL alone or in the presence of each of the monovalent cations was determined to occur at 65 degrees C. However, the maximum exposure of hydrophobic surfaces on GroEL in the presence of magnesium, manganese, cobalt or nickel was found to occur at 71 degrees C indicating that GroEL is significantly stabilized against thermal denaturation by these divalent cations. Magnesium 232-241 heat shock protein family D (Hsp60) member 1 Homo sapiens 207-212 12874120-10 2003 The cytochemical stainings and experimental manipulations of cyclic nucleotide levels provide clear evidence that NO/cGMP/PKG signalling is permissive for MG neuron migration, whereas the cAMP/PKA cascade may be a negative regulator. Magnesium 155-157 protein kinase cGMP-dependent 1 Homo sapiens 122-125 14596321-8 2003 These results confirmed the blockage of K(df), K(Ca), K(ATP) and Ca channels in VSMC and VEC by magnesium salts, the relationship between Mg2+ ions and internal Na and demonstrated the possible intervention of a Na+/Mg2+ exchanger. Magnesium 96-105 casein kappa Homo sapiens 47-52 12897770-5 2003 The allosteric magnesium, present in most PBGS, has a binding site in the octamer but not in the hexamer. Magnesium 15-24 aminolevulinate dehydratase Homo sapiens 42-46 12897770-6 2003 The unprecedented structural rearrangement reported here relates to the allosteric regulation of PBGS and suggests that alternative PBGS oligomers may function in a magnesium-dependent regulation of tetrapyrrole biosynthesis in plants and some bacteria. Magnesium 165-174 aminolevulinate dehydratase Homo sapiens 97-101 12897770-6 2003 The unprecedented structural rearrangement reported here relates to the allosteric regulation of PBGS and suggests that alternative PBGS oligomers may function in a magnesium-dependent regulation of tetrapyrrole biosynthesis in plants and some bacteria. Magnesium 165-174 aminolevulinate dehydratase Homo sapiens 132-136 14682186-7 2003 The CaSR is also expressed in the thyroid, kidney, bone and in neuronal and glial cell populations, where it should be involved in the complex responses associated with calcium and magnesium ions present in the extracellular fluids. Magnesium 181-190 calcium sensing receptor Homo sapiens 4-8 12924947-5 2003 (2) At magnesium ion concentrations optimal for splicing (20 mM), two Mrs1 dimers bind with strong cooperativity to the bI3 RNA. Magnesium 7-16 Mrs1p Saccharomyces cerevisiae S288C 70-74 12888628-9 2003 Caspase-3 was highly activated in Mg-free cultures after 48 h of treatment compared with 0.8 and 5.6 mmol/L conditions (P < 0.05). Magnesium 34-36 caspase 3 Rattus norvegicus 0-9 12887921-2 2003 Here, we show that while TRPM7"s kinase domain is not essential for activation of its channel, a functional coupling exists such that structural alterations of the kinase domain alter the sensitivity of channel activation to Mg(2+). Magnesium 225-227 transient receptor potential cation channel subfamily M member 7 Homo sapiens 25-30 12887921-3 2003 Investigation of the relationship between Mg(2+) and the cell biological role of TRPM7 revealed that TRPM7-deficient cells become Mg(2+) deficient, that both the viability and proliferation of TRPM7-deficient cells are rescued by supplementation of extracellular Mg(2+), and that the capacity of heterologously expressed TRPM7 mutants to complement TRPM7 deficiency correlates with their sensitivity to Mg(2+). Magnesium 42-44 transient receptor potential cation channel subfamily M member 7 Homo sapiens 101-106 12887921-3 2003 Investigation of the relationship between Mg(2+) and the cell biological role of TRPM7 revealed that TRPM7-deficient cells become Mg(2+) deficient, that both the viability and proliferation of TRPM7-deficient cells are rescued by supplementation of extracellular Mg(2+), and that the capacity of heterologously expressed TRPM7 mutants to complement TRPM7 deficiency correlates with their sensitivity to Mg(2+). Magnesium 42-44 transient receptor potential cation channel subfamily M member 7 Homo sapiens 101-106 12887921-3 2003 Investigation of the relationship between Mg(2+) and the cell biological role of TRPM7 revealed that TRPM7-deficient cells become Mg(2+) deficient, that both the viability and proliferation of TRPM7-deficient cells are rescued by supplementation of extracellular Mg(2+), and that the capacity of heterologously expressed TRPM7 mutants to complement TRPM7 deficiency correlates with their sensitivity to Mg(2+). Magnesium 42-44 transient receptor potential cation channel subfamily M member 7 Homo sapiens 101-106 12887921-3 2003 Investigation of the relationship between Mg(2+) and the cell biological role of TRPM7 revealed that TRPM7-deficient cells become Mg(2+) deficient, that both the viability and proliferation of TRPM7-deficient cells are rescued by supplementation of extracellular Mg(2+), and that the capacity of heterologously expressed TRPM7 mutants to complement TRPM7 deficiency correlates with their sensitivity to Mg(2+). Magnesium 130-132 transient receptor potential cation channel subfamily M member 7 Homo sapiens 81-86 12887921-3 2003 Investigation of the relationship between Mg(2+) and the cell biological role of TRPM7 revealed that TRPM7-deficient cells become Mg(2+) deficient, that both the viability and proliferation of TRPM7-deficient cells are rescued by supplementation of extracellular Mg(2+), and that the capacity of heterologously expressed TRPM7 mutants to complement TRPM7 deficiency correlates with their sensitivity to Mg(2+). Magnesium 130-132 transient receptor potential cation channel subfamily M member 7 Homo sapiens 81-86 12853607-3 2003 Ban hydrolyses ATP, unwinds DNA and forms hexamers in the presence of ATP and magnesium ions. Magnesium 78-87 replicative DNA helicase Escherichia phage P1 0-3 14565560-0 2003 Phloroglucinol: novel synthesis and role of the magnesium cation on its binding with human serum albumin (HSA) using a biochromatographic approach based on Langmuir isotherms. Magnesium 48-57 albumin Homo sapiens 91-104 12878128-3 2003 Its dosimetric properties show the feasibility of application of LiF:Mg,Cu,Na,Si TL detector to personal dosimetry fields. Magnesium 69-71 LIF interleukin 6 family cytokine Homo sapiens 65-68 12827022-0 2003 Effect of magnesium on mRNA expression and production of endothelin-1 in DOCA-salt hypertensive rats. Magnesium 10-19 endothelin 1 Rattus norvegicus 57-69 12827022-3 2003 Mg supplementation for 8 weeks lowered blood pressure in DOCA-salt hypertensive rats and prevented hypertrophies and the increase of endothelin-1 expression and production in the heart, aorta, and kidney. Magnesium 0-2 endothelin 1 Rattus norvegicus 133-145 12931892-5 2003 Total CO2 production (mg CO2-C kg(-1) soil) was 6.3, 7.0, and 10.1 in the PD and 3.6, 4.0, and 4.5 in the MWD cores amended with Br-, Br(-) + NO3-, and Br(-) + NO3(-) + DOC, respectively. Magnesium 22-24 complement C2 Homo sapiens 6-9 12831948-14 2003 Apolipoprotein A1 was lowest when dietary magnesium and copper were low. Magnesium 42-51 apolipoprotein A1 Homo sapiens 0-17 12781484-8 2003 The second group, orf3, 9, and 10, was induced at 37 degrees C by magnesium depletion (produced by EDTA treatment of growth medium). Magnesium 66-75 orf3 Rhodococcus equi 18-22 12773697-0 2003 Dietary magnesium intake influences circulating pro-inflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stress. Magnesium 8-17 pyroglutamylated RFamide peptide Rattus norvegicus 65-77 12827022-4 2003 Treatment with a receptor ETA antagonist, ABT-627, was used to clarify the relationship between the lowering effect of Mg supplementation on blood pressure and endothelin-1 production. Magnesium 119-121 endothelin 1 Rattus norvegicus 160-172 12827022-6 2003 In conclusion, these findings suggest that the lowering effect of Mg supplementation on blood pressure requires an inhibitory effect on endothelin-1 activity and/or endothelin-1 production in DOCA-salt hypertensive rats. Magnesium 66-68 endothelin 1 Rattus norvegicus 136-148 12827022-6 2003 In conclusion, these findings suggest that the lowering effect of Mg supplementation on blood pressure requires an inhibitory effect on endothelin-1 activity and/or endothelin-1 production in DOCA-salt hypertensive rats. Magnesium 66-68 endothelin 1 Rattus norvegicus 165-177 12759143-5 2003 Moreover, at 8 days, RT-PCR analysis indicated higher level of mRNA rat pre-pro complement C3 in liver from Mg-deficient rats compared to control rats. Magnesium 108-110 complement C3 Rattus norvegicus 80-93 12782329-2 2003 In addition to a magnesium ion, which is essential for catalysis, a potassium ion bound adjacent to the triphosphate moiety of ATP in a rat mitochondrial protein kinase, BCK (branched-chain alpha-ketoacid dehydrogenase kinase), has been shown to be indispensable for nucleotide binding and hydrolysis. Magnesium 17-26 creatine kinase B Rattus norvegicus 175-225 12761106-1 2003 Salivary histatin 5 (Hst 5), a potent toxin for the human fungal pathogen Candida albicans, induces noncytolytic efflux of cellular ATP, potassium, and magnesium in the absence of cytolysis, implicating these ion movements in the toxin"s fungicidal activity. Magnesium 152-161 histatin 3 Homo sapiens 9-19 12761106-1 2003 Salivary histatin 5 (Hst 5), a potent toxin for the human fungal pathogen Candida albicans, induces noncytolytic efflux of cellular ATP, potassium, and magnesium in the absence of cytolysis, implicating these ion movements in the toxin"s fungicidal activity. Magnesium 152-161 histatin 3 Homo sapiens 21-26 12892378-0 2003 Suppression of neutrophil and endothelial activation by substance P receptor blockade in the Mg-deficient rat. Magnesium 93-95 tachykinin receptor 1 Rattus norvegicus 56-76 12892382-14 2003 CONCLUSION: These results may suggest that the severity of AMI is reflected by the blood IL-6 and MMP-1 levels and that pretreatment with Mg administration protects the myocardium of patients with AMI from reperfusion injury induced by IL-6 and MMP-1. Magnesium 138-140 interleukin 6 Homo sapiens 89-93 12892382-14 2003 CONCLUSION: These results may suggest that the severity of AMI is reflected by the blood IL-6 and MMP-1 levels and that pretreatment with Mg administration protects the myocardium of patients with AMI from reperfusion injury induced by IL-6 and MMP-1. Magnesium 138-140 matrix metallopeptidase 1 Homo sapiens 98-103 12892382-14 2003 CONCLUSION: These results may suggest that the severity of AMI is reflected by the blood IL-6 and MMP-1 levels and that pretreatment with Mg administration protects the myocardium of patients with AMI from reperfusion injury induced by IL-6 and MMP-1. Magnesium 138-140 interleukin 6 Homo sapiens 236-240 12892382-14 2003 CONCLUSION: These results may suggest that the severity of AMI is reflected by the blood IL-6 and MMP-1 levels and that pretreatment with Mg administration protects the myocardium of patients with AMI from reperfusion injury induced by IL-6 and MMP-1. Magnesium 138-140 matrix metallopeptidase 1 Homo sapiens 245-250 12624104-4 2003 The magnesium requirement and pH dependence of the exonuclease and endonuclease activities of APE1 are significantly different. Magnesium 4-13 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 94-98 12697280-1 2003 The present study was designed to test the hypothesis that administration of low extracellular levels of magnesium ions ([Mg(2+)](o)) to primary cultured cerebral vascular smooth muscle cells will cause lipid peroxidation, degradation of IkappaB-alpha, and activation of nuclear transcription factor kappa B (NF-kappaB) in cultured cerebral vascular smooth muscle cells. Magnesium 105-114 nuclear factor kappa B subunit 1 Homo sapiens 309-318 12726991-1 2003 Active cathepsin B has been found in cell extract and medium of human osteoblast-like cells and MG-63 cells. Magnesium 96-98 cathepsin B Homo sapiens 7-18 12739161-4 2003 In this study the same results were obtained when PTK activities were measured under the conditions used to measure KCC activity and which prevent any change in intracellular [Mg(2+)]. Magnesium 176-178 protein tyrosine kinase 2 beta Homo sapiens 50-53 12842447-8 2003 The inhibition and downregulation of MT1-MMP by clodronate can be related to their ability to reduce MG-63 osteosarcoma cell invasion and spread. Magnesium 101-103 matrix metallopeptidase 14 Homo sapiens 37-44 12662932-5 2003 However, in TMPK(Mtub) the LID closure couples to the binding with an unusual location for a magnesium ion coordinating TMP in the active site. Magnesium 93-102 deoxythymidylate kinase Homo sapiens 12-16 12662932-8 2003 On the other hand, the usual NTP-bound magnesium is not seen in our structures and Arg14, a P-loop residue unique to TMPK(Mtub), may take over its role. Magnesium 39-48 deoxythymidylate kinase Homo sapiens 117-121 12654267-3 2003 We report the crystal structure of (GroEL-KMgATP)(14) refined to 2.0 A resolution in which the ATP triphosphate moiety is directly coordinated by both K(+) and Mg(2+). Magnesium 43-45 heat shock protein family D (Hsp60) member 1 Homo sapiens 36-41 12663588-0 2003 Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Magnesium 5-14 insulin Homo sapiens 40-47 12663588-1 2003 OBJECTIVE: To determine whether oral magnesium supplementation (as magnesium chloride [MgCl(2)] solution) improves both insulin sensitivity and metabolic control in type 2 diabetic subjects with decreased serum magnesium levels. Magnesium 37-46 insulin Homo sapiens 120-127 12749615-2 2003 Lower levels of dietary and serum magnesium have been associated with an increased prevalence of hypertension, insulin resistance, and diabetes. Magnesium 34-43 insulin Homo sapiens 111-118 12569264-4 2003 To verify that Ang II directly influences Na -dependent Mg exchange, in-vitro studies were performed in vascular smooth muscle cells (VSMCs) derived from mesenteric arteries. Magnesium 56-58 angiotensinogen Rattus norvegicus 15-21 12582169-5 2003 Increasing external Mg(2+) mimicked the progressive rightward shifts of E235A and E235R by gradually shifting activation (V(12) = 1 < 3 < 10 < 30 mm); Delta V(12) induced by 30 mm Mg(2+) was significantly attenuated for E235A (+7.9 +/- 1.2 versus +11.3 +/- 0.9 mV for wild-type HCN1) and E235R (+3.3 +/- 1.4 mV) channels, as if surface charges were already shielded. Magnesium 20-22 hyperpolarization activated cyclic nucleotide gated potassium channel 1 Homo sapiens 287-291 12637029-3 2003 NTPDase 1 hydrolyzed ATP and ADP following Michaelis-Menten kinetics with V=1278.7+/-38.4 nmol Pi/min/mg and K(M)=83.3+/-2.5 microM and V=473.9+/-18.9 nmol Pi/min/mg and K(M)=150.6+/-6.0 microM, respectively, but in the absence of magnesium and calcium ions, ATP or ADP hydrolysis was negligible. Magnesium 231-240 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 0-9 12637029-4 2003 The stimulation of the NTPDase1 by calcium (V=1084.7+/-32.5 nmol Pi/min/mg; and K(M)=377.8+/-11.3 microM) and magnesium (V=1367.2+/-41.0 nmol Pi/min/mg and K(M)=595.3+/-17.8 microM) ions suggested that each ion could replace the other during the catalytic cycle of the enzyme. Magnesium 110-119 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 23-31 12627962-7 2003 The velocity dependence on magnesium at saturating concentrations of the protein substrate, Ets138, over a range of ATP4- and Mg2+ ion concentrations, supports the notion that magnesium is an essential activator of ERK2. Magnesium 176-185 mitogen-activated protein kinase 1 Homo sapiens 215-219 12627962-0 2003 Physiological concentrations of divalent magnesium ion activate the serine/threonine specific protein kinase ERK2. Magnesium 41-50 mitogen-activated protein kinase 1 Homo sapiens 109-113 12627962-6 2003 Now we provide kinetic evidence that ERK2 must bind two divalent magnesium ions to facilitate catalysis at a physiologically relevant rate, because a second magnesium ion promotes both MgATP2- binding and phosphoryl transfer. Magnesium 65-74 mitogen-activated protein kinase 1 Homo sapiens 37-41 12627962-6 2003 Now we provide kinetic evidence that ERK2 must bind two divalent magnesium ions to facilitate catalysis at a physiologically relevant rate, because a second magnesium ion promotes both MgATP2- binding and phosphoryl transfer. Magnesium 157-166 mitogen-activated protein kinase 1 Homo sapiens 37-41 12627962-7 2003 The velocity dependence on magnesium at saturating concentrations of the protein substrate, Ets138, over a range of ATP4- and Mg2+ ion concentrations, supports the notion that magnesium is an essential activator of ERK2. Magnesium 27-36 mitogen-activated protein kinase 1 Homo sapiens 215-219 12505440-3 2003 The generation of C3b stimulated by these metals (<0.5 mM) proceeds up to about four times faster than the stimulation by Mg(2+). Magnesium 125-127 complement C3 Homo sapiens 18-21 12633766-3 2003 Results Using D-BUT-CHT-lys-pNA as a plasmin-specific substrate, we show that incubation of plasma with fructose, glyceraldehyde or MG but not glucose decreases plasminogen activity reaching more than 40% in 16 h. A parallel dose-dependent decrease in heparin activation of AT III by up to a 50% was demonstrated using SAR-PRO-ARG-pNA as a specific thrombin substrate. Magnesium 132-134 serpin family C member 1 Homo sapiens 274-280 12633766-3 2003 Results Using D-BUT-CHT-lys-pNA as a plasmin-specific substrate, we show that incubation of plasma with fructose, glyceraldehyde or MG but not glucose decreases plasminogen activity reaching more than 40% in 16 h. A parallel dose-dependent decrease in heparin activation of AT III by up to a 50% was demonstrated using SAR-PRO-ARG-pNA as a specific thrombin substrate. Magnesium 132-134 coagulation factor II, thrombin Homo sapiens 349-357 12735482-6 2003 These changes were consecutive to the expression of matrix metalloproteinases (MMP) -2 and -9 which were present as zymogens (inactive forms) in controls and supposed to be present in their active and inactive forms in magnesium-deficient mice (zymography). Magnesium 219-228 matrix metallopeptidase 2 Mus musculus 52-93 12606767-5 2003 Mutation within the putative nuclear localization sequence (NLS) resulted in AHR mutants that were severely defective in nuclear import as evaluated by immunocytochemical staining after exposure to TCDD, GA, or MG-132. Magnesium 211-213 aryl-hydrocarbon receptor Mus musculus 77-80 12573214-5 2003 Nocturnin nuclease activity is magnesium dependent, as the addition of EDTA or mutation of the residue predicted to bind magnesium disrupts deadenylation. Magnesium 31-40 nocturnin S homeolog Xenopus laevis 0-9 12573214-5 2003 Nocturnin nuclease activity is magnesium dependent, as the addition of EDTA or mutation of the residue predicted to bind magnesium disrupts deadenylation. Magnesium 121-130 nocturnin S homeolog Xenopus laevis 0-9 12535739-6 2003 Magnesium reduced MMP-2 production dose-dependently at basal and PDGF-stimulated conditions in VSMCs. Magnesium 0-9 matrix metallopeptidase 2 Rattus norvegicus 18-23 12535739-8 2003 The effect of magnesium on the production of MMP-2 was inhibited by two tyrosine kinase inhibitors-genistein and herbimycin A. Magnesium 14-23 matrix metallopeptidase 2 Rattus norvegicus 45-50 12535739-9 2003 The results of this study indicate that extracellularly added magnesium decreased MMPs secretion, which appears to be associated with protein tyrosine kinase. Magnesium 62-71 matrix metallopeptidase 2 Rattus norvegicus 82-86 12582016-4 2003 In this generally well-nourished population of middle-aged to elderly men, plasma IGF-I and IGF-I:IGF-binding protein-3 molar ratio tended to increase with higher intake of protein and minerals, including potassium, zinc, magnesium, calcium, and phosphorus. Magnesium 222-231 insulin like growth factor 1 Homo sapiens 92-119 12556415-8 2003 The BDNF-evoked release was abolished in low-calcium/high-magnesium medium. Magnesium 58-67 LOW QUALITY PROTEIN: brain-derived neurotrophic factor Oryctolagus cuniculus 4-8 12537988-0 2003 Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Magnesium 8-17 insulin Homo sapiens 21-28 12537988-4 2003 In vitro and in vivo studies have demonstrated that insulin may modulate the shift of Mg from extracellular to intracellular space. Magnesium 86-88 insulin Homo sapiens 52-59 12537988-5 2003 Intracellular Mg concentration has also been shown to be effective in modulating insulin action (mainly oxidative glucose metabolism), offset calcium-related excitation-contraction coupling, and decrease smooth cell responsiveness to depolarizing stimuli. Magnesium 14-16 insulin Homo sapiens 81-88 12537988-6 2003 A poor intracellular Mg concentration, as found in noninsulin-dependent diabetes mellitus (NIDDM) and in hypertensive patients, may result in a defective tyrosine-kinase activity at the insulin receptor level and exaggerated intracellular calcium concentration. Magnesium 21-23 insulin receptor Homo sapiens 186-202 12537988-8 2003 By contrast, in NIDDM patients daily Mg administration, restoring a more appropriate intracellular Mg concentration, contributes to improve insulin-mediated glucose uptake. Magnesium 37-39 insulin Homo sapiens 140-147 12537988-8 2003 By contrast, in NIDDM patients daily Mg administration, restoring a more appropriate intracellular Mg concentration, contributes to improve insulin-mediated glucose uptake. Magnesium 99-101 insulin Homo sapiens 140-147 12537988-10 2003 In conclusion, a growing body of studies suggest that intracellular Mg may play a key role in modulating insulin-mediated glucose uptake and vascular tone. Magnesium 68-70 insulin Homo sapiens 105-112 12619798-3 2003 In Experiment 1, an in vitro enzyme assay was used to evaluate the effects of Zn, Cu, Mg, and Mn on the activity of microbial uricase. Magnesium 86-88 urate oxidase (pseudogene) Homo sapiens 126-133 12623444-8 2003 Both platelet AC and cloned AC-III required Mg(2+) for activity, were insensitive to Ca(2+) and were G(s)- and G(i)-coupled. Magnesium 44-46 adenylate cyclase 3 Homo sapiens 28-34 18365063-3 2003 While AI(III) ion forms various 1:1 complexes of different protonation states in the pH range 2-7, Ca(ll), Mg(ll) ions seem to interact with SalGly only in the basic pH range and form mixed hydroxo species MLH(-1) at pH approximately 8. Magnesium 107-109 mutL homolog 1 Homo sapiens 206-212 12524281-0 2003 Effect of external magnesium and calcium on human connexin46 hemichannels. Magnesium 19-28 gap junction protein alpha 3 Homo sapiens 50-60 12524281-8 2003 In addition, we identified a mutation in the first extracellular domain of hCx46 (hCx46*N63S) that resulted in hemichannels that showed increased sensitivity to magnesium blockade. Magnesium 161-170 gap junction protein alpha 3 Homo sapiens 75-80 12524281-8 2003 In addition, we identified a mutation in the first extracellular domain of hCx46 (hCx46*N63S) that resulted in hemichannels that showed increased sensitivity to magnesium blockade. Magnesium 161-170 gap junction protein alpha 3 Homo sapiens 82-92 12393545-4 2003 We correlated the molecular data to the severe clinical phenotype of the patient by means of altered enzymatic properties of partially purified hexokinase from the patient, notably with respect to Mg(2+)-ATP binding. Magnesium 197-199 hexokinase 1 Homo sapiens 144-154 12974195-8 2003 The intensities of i-NOS and c-NOS of MG were significantly higher in group I than in group II (p < 0.05) with no significant differences in other areas (p > 0.05, respectively). Magnesium 38-40 nitric oxide synthase 3 Homo sapiens 29-34 12679171-6 2003 Treating HepG2 cells with other minerals known to have insulin-sensitizing effects such as magnesium (1 mM), zinc (0.2 mM), and vanadyl sulfate (0.1 mM) significantly reduced apoA-I promoter activity in the presence and absence of 100 microU/mL of insulin. Magnesium 91-100 insulin Homo sapiens 55-62 12679171-6 2003 Treating HepG2 cells with other minerals known to have insulin-sensitizing effects such as magnesium (1 mM), zinc (0.2 mM), and vanadyl sulfate (0.1 mM) significantly reduced apoA-I promoter activity in the presence and absence of 100 microU/mL of insulin. Magnesium 91-100 apolipoprotein A1 Homo sapiens 175-181 12679171-6 2003 Treating HepG2 cells with other minerals known to have insulin-sensitizing effects such as magnesium (1 mM), zinc (0.2 mM), and vanadyl sulfate (0.1 mM) significantly reduced apoA-I promoter activity in the presence and absence of 100 microU/mL of insulin. Magnesium 91-100 insulin Homo sapiens 248-255 12649494-7 2003 Overexpression of MRS2, which encodes a mitochondrial magnesium carrier, partially suppresses translational inhibition by each isolated negatively acting element, but does not suppress them in combination. Magnesium 54-63 Mrs2p Saccharomyces cerevisiae S288C 18-22 12569264-13 2003 CONCLUSIONS: Our data demonstrate that inhibitors of Na -dependent Mg transport attenuate development of hypertension in rats infused with Ang II. Magnesium 67-69 angiotensinogen Rattus norvegicus 139-145 12569264-14 2003 These findings suggest a possible role for Na /Mg exchange activity in the pathogenesis of Ang II-dependent hypertension. Magnesium 47-49 angiotensinogen Rattus norvegicus 91-97 12569264-9 2003 Platelet intracellular free Mg concentration was reduced and platelet intracellular free Na concentration was increased in the Ang II group compared with control and treated groups (P < 0.01). Magnesium 28-30 angiotensinogen Rattus norvegicus 127-133 12777712-0 2003 Rat polymerase beta gapped DNA interactions: antagonistic effects of the 5" terminal PO4 - group and magnesium on the enzyme binding to the gapped DNAs with different ssDNA gaps. Magnesium 101-110 DNA polymerase beta Rattus norvegicus 4-19 12777712-1 2003 The role of the 5" terminal phosphate group downstream from the primer and magnesium cations in the energetics and dynamics of the gapped DNA recognition by rat polymerase beta have been examined, using the fluorescence titration and stopped-flow techniques. Magnesium 75-84 DNA polymerase beta Rattus norvegicus 161-176 12573695-6 2003 Most PBGS are also found to contain the binding determinants for an allosteric magnesium that resides outside the active site. Magnesium 79-88 aminolevulinate dehydratase Homo sapiens 5-9 12459913-2 2003 The PBGS protein sequence contains a unique metal switch region that has been postulated to dictate an exclusive catalytic use of either zinc or magnesium, and perhaps also potassium. Magnesium 145-154 aminolevulinate dehydratase Homo sapiens 4-8 12459913-3 2003 In some PBGS, the cysteines of the metal switch sequence DXCXCX(Y/F)X(3)G(H/Q)CG have been demonstrated to bind a catalytic zinc, and in other PBGS, the aspartic acid residues of the metal switch sequence DXALDX(Y/F)X(3)G(H/Q)DG have been postulated to bind a catalytically essential magnesium and/or potassium. Magnesium 284-293 aminolevulinate dehydratase Homo sapiens 8-12 12459913-3 2003 In some PBGS, the cysteines of the metal switch sequence DXCXCX(Y/F)X(3)G(H/Q)CG have been demonstrated to bind a catalytic zinc, and in other PBGS, the aspartic acid residues of the metal switch sequence DXALDX(Y/F)X(3)G(H/Q)DG have been postulated to bind a catalytically essential magnesium and/or potassium. Magnesium 284-293 aminolevulinate dehydratase Homo sapiens 143-147 12459913-5 2003 The resultant chimeric PBGS proteins, peainhuman PBGS and psuinhuman PBGS, are substantially activated by both magnesium and potassium, but not by zinc. Magnesium 111-120 aminolevulinate dehydratase Homo sapiens 23-27 12459913-5 2003 The resultant chimeric PBGS proteins, peainhuman PBGS and psuinhuman PBGS, are substantially activated by both magnesium and potassium, but not by zinc. Magnesium 111-120 aminolevulinate dehydratase Homo sapiens 49-53 12459913-5 2003 The resultant chimeric PBGS proteins, peainhuman PBGS and psuinhuman PBGS, are substantially activated by both magnesium and potassium, but not by zinc. Magnesium 111-120 aminolevulinate dehydratase Homo sapiens 49-53 12508053-2 2003 We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide-regulated metal ion currents (MagNuM). Magnesium 122-124 transient receptor potential cation channel subfamily M member 7 Homo sapiens 63-68 12508053-2 2003 We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide-regulated metal ion currents (MagNuM). Magnesium 122-124 transient receptor potential cation channel subfamily M member 7 Homo sapiens 70-76 12508053-2 2003 We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide-regulated metal ion currents (MagNuM). Magnesium 122-124 transient receptor potential cation channel subfamily M member 7 Homo sapiens 78-83 12508053-2 2003 We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide-regulated metal ion currents (MagNuM). Magnesium 122-124 transient receptor potential cation channel subfamily M member 7 Homo sapiens 85-93 12508053-2 2003 We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide-regulated metal ion currents (MagNuM). Magnesium 122-124 transient receptor potential cation channel subfamily M member 7 Homo sapiens 249-254 12508053-2 2003 We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide-regulated metal ion currents (MagNuM). Magnesium 200-202 transient receptor potential cation channel subfamily M member 7 Homo sapiens 63-68 12508053-2 2003 We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide-regulated metal ion currents (MagNuM). Magnesium 200-202 transient receptor potential cation channel subfamily M member 7 Homo sapiens 70-76 12508053-2 2003 We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide-regulated metal ion currents (MagNuM). Magnesium 200-202 transient receptor potential cation channel subfamily M member 7 Homo sapiens 78-83 12508053-2 2003 We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide-regulated metal ion currents (MagNuM). Magnesium 200-202 transient receptor potential cation channel subfamily M member 7 Homo sapiens 85-93 12508053-2 2003 We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide-regulated metal ion currents (MagNuM). Magnesium 200-202 transient receptor potential cation channel subfamily M member 7 Homo sapiens 249-254 12739895-4 2003 To explore a new approach for characterizing the MG conformation, cyclic voltametric studies of n-alkyl sulfates induced transition at acidic pH of cytochrome c (unfolded state, U) was carried out. Magnesium 49-51 cytochrome c, somatic Homo sapiens 148-160 12486495-1 2002 Low serum magnesium levels are related to diabetes mellitus (DM) and high blood pressure (HBP), but as far as we know, there are no previous reports that analyzed the serum magnesium concentration in individuals with metabolic syndrome (MS). Magnesium 10-19 high density lipoprotein binding protein Homo sapiens 69-88 23300395-5 2003 (4) In addition, magnesium is a cofactor regulating a number of enzymatic and cellular activities in the body, including adenyl cyclase and sodium-potassium ATP-ase, potentially enhancing the effects of beta2-agonists. Magnesium 17-26 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 203-208 12518234-3 2003 The results showed that the deletion of PHO85 or PHO80 gene both increased sensibility of Sacchromyces cerevisiae to ions K(+), Mg(2+), Zn(2+), Ca(2+) and Mn(2+), while the deletion of pap1(pcl-7) gene did not lead to such phenotype. Magnesium 128-130 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 40-45 12518234-3 2003 The results showed that the deletion of PHO85 or PHO80 gene both increased sensibility of Sacchromyces cerevisiae to ions K(+), Mg(2+), Zn(2+), Ca(2+) and Mn(2+), while the deletion of pap1(pcl-7) gene did not lead to such phenotype. Magnesium 128-130 Pho80p Saccharomyces cerevisiae S288C 49-54 12540952-9 2003 At 0.5 mmol/l magnesium in the blood, 10-35% of the patient samples had INR deviations greater than 10%, depending on the thromboplastin reagent used. Magnesium 14-23 coagulation factor III, tissue factor Bos taurus 122-136 12397067-0 2002 Engineering competitive magnesium binding into the first EF-hand of skeletal troponin C. The goal of this study was to examine the mechanism of magnesium binding to the regulatory domain of skeletal troponin C (TnC). Magnesium 24-33 tenascin C Homo sapiens 211-214 12397067-0 2002 Engineering competitive magnesium binding into the first EF-hand of skeletal troponin C. The goal of this study was to examine the mechanism of magnesium binding to the regulatory domain of skeletal troponin C (TnC). Magnesium 144-153 tenascin C Homo sapiens 211-214 12397067-1 2002 The fluorescence of Trp(29), immediately preceding the first calcium-binding loop in TnC(F29W), was unchanged by addition of magnesium, but increased upon calcium binding with an affinity of 3.3 microm. Magnesium 125-134 tenascin C Homo sapiens 85-88 12397067-2 2002 However, the calcium-dependent increase in TnC(F29W) fluorescence could be reversed by addition of magnesium, with a calculated competitive magnesium affinity of 2.2 mm. Magnesium 99-108 tenascin C Homo sapiens 43-46 12397067-2 2002 However, the calcium-dependent increase in TnC(F29W) fluorescence could be reversed by addition of magnesium, with a calculated competitive magnesium affinity of 2.2 mm. Magnesium 140-149 tenascin C Homo sapiens 43-46 12397067-3 2002 When a Z acid pair was introduced into the first EF-hand of TnC(F29W), the fluorescence of G34DTnC(F29W) increased upon addition of magnesium or calcium with affinities of 295 and 1.9 microm, respectively. Magnesium 132-141 tenascin C Homo sapiens 60-63 12397067-4 2002 Addition of 3 mm magnesium decreased the calcium sensitivity of TnC(F29W) and G34DTnC(F29W) approximately 2- and 6-fold, respectively. Magnesium 17-26 tenascin C Homo sapiens 64-67 12397067-5 2002 Exchange of G34DTnC(F29W) into skinned psoas muscle fibers decreased fiber calcium sensitivity approximately 1.7-fold compared with TnC(F29W) at 1 mm [magnesium](free) and approximately 3.2-fold at 3 mm [magnesium](free). Magnesium 151-160 tenascin C Homo sapiens 16-19 12397067-5 2002 Exchange of G34DTnC(F29W) into skinned psoas muscle fibers decreased fiber calcium sensitivity approximately 1.7-fold compared with TnC(F29W) at 1 mm [magnesium](free) and approximately 3.2-fold at 3 mm [magnesium](free). Magnesium 204-213 tenascin C Homo sapiens 16-19 12397067-7 2002 Furthermore, the data suggests that the second EF-hand, but not the first, of TnC is responsible for the competitive magnesium binding to the regulatory domain. Magnesium 117-126 tenascin C Homo sapiens 78-81 12361950-7 2002 The enzymological properties (pH optimum, dependence on magnesium or manganese as a cofactor, the dependence of activity on Triton X-100, the dependence on the PI surface concentration, and temperature sensitivity) of the LSB6-encoded enzyme were very similar to the membrane-associated 55-kDa PI 4-kinase previously purified from S. cerevisiae. Magnesium 56-65 1-phosphatidylinositol 4-kinase LSB6 Saccharomyces cerevisiae S288C 222-226 12450669-1 2002 Catechol O-methyltransferase (COMT) transfers a methyl group from S-adenosyl-L-methionine to the catechol substrate in the presence of magnesium. Magnesium 135-144 catechol-O-methyltransferase Homo sapiens 0-28 12450669-1 2002 Catechol O-methyltransferase (COMT) transfers a methyl group from S-adenosyl-L-methionine to the catechol substrate in the presence of magnesium. Magnesium 135-144 catechol-O-methyltransferase Homo sapiens 30-34 12635865-0 2002 Effects of a low extracellular magnesium concentration and endotoxin on IL-1beta and TNF-alpha release from, and mRNA levels in, isolated rat alveolar macrophages. Magnesium 31-40 interleukin 1 beta Rattus norvegicus 72-80 12635865-0 2002 Effects of a low extracellular magnesium concentration and endotoxin on IL-1beta and TNF-alpha release from, and mRNA levels in, isolated rat alveolar macrophages. Magnesium 31-40 tumor necrosis factor Rattus norvegicus 85-94 12635872-3 2002 These opposing changes can be explained by the known enhanced absorption of Ca relative to Mg by the gut during lactation coupled with a Ca-induced suppression of PTH-driven renal Ca and Mg reabsorption. Magnesium 187-189 parathyroid hormone Capra hircus 163-166 12635878-2 2002 The aim of this study was to quantify the decrease in serum concentration of ionized magnesium ([Mg2+]) when human serum albumin is added to neonatal serum in vitro. Magnesium 85-94 albumin Homo sapiens 115-128 12509067-5 2002 A direct impact of magnesium on the function of the transport protein p-glycoprotein at the level of the blood-brain barrier has also been demonstrated, possibly influencing the access of corticosteroids to the brain. Magnesium 19-28 ATP binding cassette subfamily B member 1 Homo sapiens 70-84 12235136-0 2002 Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase. Magnesium 128-137 ribosomal protein S6 kinase A5 Homo sapiens 48-52 12235136-7 2002 Furthermore, we demonstrate that RNA ligands can be conformation-specific probes, and this feature allowed us to describe magnesium ion-dependent conformational changes of MSK1 upon activation. Magnesium 122-131 ribosomal protein S6 kinase A5 Homo sapiens 172-176 12419497-2 2002 Here, we explored the effect of NPY application on epileptiform discharges induced by perfusion with magnesium-free solution in slices of entorhinal cortex from two different mouse strains. Magnesium 101-110 neuropeptide Y Mus musculus 32-35 12485885-3 2002 This resulted in accelerated lipofuscin accumulation (especially when MG-262 exposure was combined with mild hyperoxia-i.e., cultivation at 40% ambient oxygen versus 8% for controls); and enhanced immunostaining for ubiquitin, reflecting accumulation of modified cytosolic proteins subjected for degradation, and cathepsin L, reflecting enlargement of the lysosomal compartment. Magnesium 70-72 cathepsin L Homo sapiens 313-324 12486495-1 2002 Low serum magnesium levels are related to diabetes mellitus (DM) and high blood pressure (HBP), but as far as we know, there are no previous reports that analyzed the serum magnesium concentration in individuals with metabolic syndrome (MS). Magnesium 10-19 high density lipoprotein binding protein Homo sapiens 90-93 12486495-9 2002 Among the components of MS, dyslipidemia (OR 2.8, CI(95%) 1.3-2.9) and HBP (OR 1.9, CI(95%) 1.4-2.8) were strongly related to low serum magnesium levels. Magnesium 136-145 high density lipoprotein binding protein Homo sapiens 71-74 12392561-4 2002 At acidic pH below pH 4.5, TRAIL resulted in substantial structural changes to a molten globule (MG)-like state. Magnesium 97-99 TNF superfamily member 10 Homo sapiens 27-32 12407079-1 2002 The strong inward rectification of Kir2.1 currents is reportedly due to blockade of the outward current by cytoplasmic magnesium (Mg(2+)(i)) and polyamines, and is known to be determined in part by three negatively charged amino acid residues: Asp172, Glu224, and Glu299 (D172, E224, E299). Magnesium 119-128 potassium inwardly rectifying channel subfamily J member 2 L homeolog Xenopus laevis 35-41 12376182-0 2002 Blockade by magnesium of sodium currents in acutely isolated hippocampal CA1 neurons of rat. Magnesium 12-21 carbonic anhydrase 1 Rattus norvegicus 73-76 12154098-1 2002 A high throughput screen for neutral, magnesium-dependent sphingomyelinase (SMase) was performed. Magnesium 38-47 sphingomyelin phosphodiesterase 2 Homo sapiens 76-81 12398748-1 2002 Our results from various transport experiments on Mg1-xB2 indicate a surprising effect associated with the presence of a Mg deficiency in MgB2: the phase separation between Mg-vacancy rich and Mg-vacancy poor phases. Magnesium 50-52 secretoglobin family 2A member 1 Homo sapiens 138-142 12398748-1 2002 Our results from various transport experiments on Mg1-xB2 indicate a surprising effect associated with the presence of a Mg deficiency in MgB2: the phase separation between Mg-vacancy rich and Mg-vacancy poor phases. Magnesium 121-123 mucin 5B, oligomeric mucus/gel-forming Homo sapiens 50-53 12398748-1 2002 Our results from various transport experiments on Mg1-xB2 indicate a surprising effect associated with the presence of a Mg deficiency in MgB2: the phase separation between Mg-vacancy rich and Mg-vacancy poor phases. Magnesium 121-123 secretoglobin family 2A member 1 Homo sapiens 138-142 12358725-11 2002 With the exception of magnesium and copper, this novel peptidase activity had a similar requirement for metal ions as GCPII. Magnesium 22-31 folate hydrolase 1 Mus musculus 118-123 12635848-3 2002 In the present study we demonstrate that the unio also contains the putative mannose 6-phosphate receptor (MPR 46) that can be purified on the same gel in presence of divalent metal ions (10 mM each of calcium, manganese, and magnesium), and in the absence of sodium chloride and at pH 6.5. Magnesium 226-235 mannose-6-phosphate receptor, cation dependent Gallus gallus 77-105 12638423-2 2002 Activation of ATPase is accompanied with a rise of Na and P concentrations and fall in K, Mg and Ca ions concentrations. Magnesium 90-92 dynein axonemal heavy chain 8 Homo sapiens 14-20 12356882-9 2002 These results suggest that human malignant hyperthermia (MH) is associated with reduced inhibition of the RYR by (i) cytosolic Mg(2+) and (ii) SR Ca(2+) depletion. Magnesium 127-129 ryanodine receptor 1 Homo sapiens 106-109 12138121-7 2002 The binding of RRF and tRNA to ribosomes was influenced by Mg(2+) and NH(4)(+) ions in a similar manner. Magnesium 59-61 mitochondrial ribosome recycling factor Homo sapiens 15-18 12270144-3 2002 We describe here the kinetics of the interaction of GTP with the Rho family small GTPase Cdc42 in the absence and presence of Mg(2+). Magnesium 126-128 cell division cycle 42 Homo sapiens 89-94 12364856-0 2002 Magnesium supplementation prevents experimental chronic cyclosporine a nephrotoxicity via renin-angiotensin system independent mechanism. Magnesium 0-9 renin Rattus norvegicus 90-95 12206391-1 2002 The development of new techniques for measuring intracellular free Mg2+ during the 1980s has provided investigators with the tools needed to produce new insights into the regulation of cellular magnesium. Magnesium 194-203 mucin 7, secreted Homo sapiens 67-70 12050160-8 2002 In support of this notion, MDCK cells expressing TSLC1-GFP showed a significant level of cell aggregation in the absence or presence of Ca(2+) and Mg(2+). Magnesium 147-149 cell adhesion molecule 1 Canis lupus familiaris 49-54 12187089-8 2002 One month after change to the low Ca(2+) dialysate (total 12 sessions in each case), serum intact PTH levels increased significantly (186.7 +/- 19.5 vs. 216.2 +/- 21.9 pg/ml: p = 0.01) in spite of the fact that no changes were found in serum ionized Ca(2+), Pi and Mg. Magnesium 265-267 parathyroid hormone Homo sapiens 98-101 12063261-6 2002 Interestingly, we also found that specific inhibitors of ANT such as MT-21 and atractyloside could induce cytochrome c release without mitochondrial swelling and that this event was highly dependent on the presence of Mg(2+). Magnesium 218-220 solute carrier family 25 member 6 Homo sapiens 57-60 12151082-0 2002 Matrix Gla protein binding to hydroxyapatite is dependent on the ionic environment: calcium enhances binding affinity but phosphate and magnesium decrease affinity. Magnesium 136-145 matrix Gla protein Homo sapiens 0-18 12145012-7 2002 The association between whole-grain intake and fasting insulin was attenuated after adjustment for dietary fiber and magnesium. Magnesium 117-126 insulin Homo sapiens 55-62 12167797-6 2002 RESULTS: In group I, 20-mmol/L potassium ion greatly reduced the bradykinin-induced relaxation (35.0% +/- 4.9% vs 86.0% +/- 5.3%, P <.001), which was significantly restored by magnesium ion (51.9% +/- 4.0%, P =.017). Magnesium 179-188 kininogen 1 Homo sapiens 65-75 12167797-8 2002 In group IV, potassium ion depolarized the smooth muscle and decreased the bradykinin-induced hyperpolarization (-72.0 +/- 1.5 vs -61.7 +/- 0.7 mV, n = 7, P <.001), which was significantly restored by magnesium ion (-68.0 +/- 2.5 mV vs -72.5 +/- 1.5 mV, n = 6, P =.029). Magnesium 204-213 kininogen 1 Homo sapiens 75-85 12492117-2 2002 The observed Bcl-2 cleavage paralleled the degree of PS-341-induced apoptosis but was detected to a similar extent with comparable concentrations of two other proteasome inhibitors (MG-132 and PSI). Magnesium 182-184 BCL2 apoptosis regulator Homo sapiens 13-18 12185465-1 2002 Familial hypomagnesemia, hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive inherited disorder that has recently been attributed to a defect in the paracellin-1 ( PCLN-1)gene, encoding for a protein responsible for the tubular reabsorption of magnesium and calcium. Magnesium 266-275 claudin 16 Homo sapiens 171-183 12185465-1 2002 Familial hypomagnesemia, hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive inherited disorder that has recently been attributed to a defect in the paracellin-1 ( PCLN-1)gene, encoding for a protein responsible for the tubular reabsorption of magnesium and calcium. Magnesium 266-275 claudin 16 Homo sapiens 186-192 12600029-1 2002 The protective effect of magnesium on endothelial cells induced by H2O2 and t-butyl hydroperoxide and the subsequent alterations of extracellular superoxide dismutase (EC-SOD) and cellular selenium-dependent and non-selenium-dependent GSH-Px are investigated in this study. Magnesium 25-34 superoxide dismutase 3 Homo sapiens 132-166 12600029-1 2002 The protective effect of magnesium on endothelial cells induced by H2O2 and t-butyl hydroperoxide and the subsequent alterations of extracellular superoxide dismutase (EC-SOD) and cellular selenium-dependent and non-selenium-dependent GSH-Px are investigated in this study. Magnesium 25-34 superoxide dismutase 3 Homo sapiens 168-174 12136075-1 2002 In this study, the authors show that MG as an autoantibody-mediated disorder of neuromuscular transmission is associated with elevated serum levels of the interferon-gamma-inducing cytokine interleukin (IL)-18. Magnesium 37-39 interferon gamma Homo sapiens 155-171 12136075-1 2002 In this study, the authors show that MG as an autoantibody-mediated disorder of neuromuscular transmission is associated with elevated serum levels of the interferon-gamma-inducing cytokine interleukin (IL)-18. Magnesium 37-39 interleukin 18 Homo sapiens 190-209 12203347-8 2002 Delocalization of the electron on the singly occupied molecular orbital (SOMO) away from the Mg(+) ion is observed for the hexamer core structure, while at the same time this isomer is the most reactive for the hydrogen-loss reaction, with an energy barrier of only 2.7 kcal mol(-1) at the MP2/6-31G** level. Magnesium 93-98 major intrinsic protein of lens fiber Homo sapiens 290-295 12105313-6 2002 The finding of titin autoantibodies and the coexistence of thymomas were both associated with age at the appearance of MG. Magnesium 119-121 titin Homo sapiens 15-20 12121148-1 2002 A photoinduced hydrogen production system, coupling sucrose degradation with invertase and glucose dehydrogenase (GDH) and hydrogen production with colloidal platinum as a catalyst using the visible light-induced photosensitization of Mg chlorophyll-a (Mg Chl-a), has been developed. Magnesium 235-237 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 91-112 12121148-1 2002 A photoinduced hydrogen production system, coupling sucrose degradation with invertase and glucose dehydrogenase (GDH) and hydrogen production with colloidal platinum as a catalyst using the visible light-induced photosensitization of Mg chlorophyll-a (Mg Chl-a), has been developed. Magnesium 235-237 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 114-117 12105390-3 2002 While low levels of magnesium stimulate parathyroid hormone secretion, very low serum concentrations induce a paradoxical block. Magnesium 20-29 parathyroid hormone Homo sapiens 40-59 12105390-7 2002 In addition to the effects of magnesium on parathyroid hormone secretion, parathyroid hormone in turn regulates magnesium homeostasis by modulating renal magnesium reabsorption. Magnesium 30-39 parathyroid hormone Homo sapiens 43-62 12105390-7 2002 In addition to the effects of magnesium on parathyroid hormone secretion, parathyroid hormone in turn regulates magnesium homeostasis by modulating renal magnesium reabsorption. Magnesium 112-121 parathyroid hormone Homo sapiens 74-93 12105390-7 2002 In addition to the effects of magnesium on parathyroid hormone secretion, parathyroid hormone in turn regulates magnesium homeostasis by modulating renal magnesium reabsorption. Magnesium 112-121 parathyroid hormone Homo sapiens 74-93 12105390-8 2002 The distal convoluted tubule is of crucial importance for parathyroid hormone-regulated magnesium homeostasis. Magnesium 88-97 parathyroid hormone Homo sapiens 58-77 12358141-7 2002 SBP and DBP tended to be negatively associated with 24 h urinary potassium (K) and magnesium (Mg) excretion. Magnesium 83-92 selenium binding protein 1 Homo sapiens 0-3 12358141-7 2002 SBP and DBP tended to be negatively associated with 24 h urinary potassium (K) and magnesium (Mg) excretion. Magnesium 83-92 D-box binding PAR bZIP transcription factor Homo sapiens 8-11 12113878-7 2002 RESULTS: Three-day magnesium administration reduced loss of MAP-2 (from 33 of 50 to 21 of 45, P =.06) and activation of caspase-3 (from 34 of 50 to 21 of 45, P =.04) in the cerebral cortex after HI. Magnesium 19-28 caspase 3 Rattus norvegicus 120-129 12113878-10 2002 CONCLUSION: Long-term, post-HI treatment with magnesium inhibited caspase-3 activation and MAP-2 immunostaining, suggesting that magnesium inhibited apoptotic neuronal death of HI in 7-day-old rats. Magnesium 46-55 caspase 3 Rattus norvegicus 66-75 12113878-10 2002 CONCLUSION: Long-term, post-HI treatment with magnesium inhibited caspase-3 activation and MAP-2 immunostaining, suggesting that magnesium inhibited apoptotic neuronal death of HI in 7-day-old rats. Magnesium 46-55 microtubule-associated protein 2 Rattus norvegicus 91-96 12113878-10 2002 CONCLUSION: Long-term, post-HI treatment with magnesium inhibited caspase-3 activation and MAP-2 immunostaining, suggesting that magnesium inhibited apoptotic neuronal death of HI in 7-day-old rats. Magnesium 129-138 caspase 3 Rattus norvegicus 66-75 12113878-10 2002 CONCLUSION: Long-term, post-HI treatment with magnesium inhibited caspase-3 activation and MAP-2 immunostaining, suggesting that magnesium inhibited apoptotic neuronal death of HI in 7-day-old rats. Magnesium 129-138 microtubule-associated protein 2 Rattus norvegicus 91-96 12072508-6 2002 However, exposure to Mg(2+) and the nonpermissive temperature caused disruption of the tsE octamers and yielded the formation of polydisperse NSP2 aggregates, events not observed with wt octamers. Magnesium 21-23 reticulon 2 Homo sapiens 142-146 12069597-10 2002 By contrast to MRP1, orthovanadate-stimulated nucleotide trapping in rMrp6 does not occur in the presence of Mg(2+) but can be detected with Ni(2+) ions, suggesting structural and/or functional differences between the two proteins. Magnesium 109-111 ATP binding cassette subfamily C member 6 Rattus norvegicus 69-74 11937510-4 2002 We found that mutations at Zn2 or Mg sites had similar effects in PLAP and ECAP but that the environment of the Zn1 ion in PLAP is less affected by substitutions than that in ECAP. Magnesium 34-36 alkaline phosphatase, placental Homo sapiens 66-70 12044876-2 2002 We show that purified REV1 protein inserts dCMP opposite template G, A, T and C, and dGMP and dTMP opposite template G in the presence of magnesium, while in the presence of manganese the specificity for dCMP was found to be relaxed and the REV1 protein acquired the ability to insert dCMP, dGMP, dAMP and dTMP opposite templates G, A, T, and C. Kinetic analysis provided evidence for high affinity for dCTP with template G, suggesting that the REV1 protein is specialized for dCTP and template G. Magnesium 138-147 REV1 DNA directed polymerase Homo sapiens 22-26 12046038-9 2002 Time-dependent PTH levels were associated directly with duration of dialysis therapy and use of vitamin D and phosphate and albumin levels, but inversely with age and ionized calcium and magnesium levels (but not glucose or HbA1c levels). Magnesium 187-196 parathyroid hormone Homo sapiens 15-18 12204438-2 2002 The pyruvate kinase activation by low concentration of pyrophosphate and inhibition by high concentration of pyrophosphate was considered to be the result of reversible reactions of magnesium cation with pyrophosphate, ADP, ATP, and PEP. Magnesium 182-191 prolyl endopeptidase Homo sapiens 233-236 12117304-0 2002 Magnesium supplementation and deoxycorticosterone acetate--salt hypertension: effect on arterial mechanical properties and on activity of endothelin-1. Magnesium 0-9 endothelin 1 Rattus norvegicus 138-150 12117304-1 2002 The aim of this study was to show whether the decrease in blood pressure induced by Mg supplementation in deoxycorticosterone acetate - salt (DOCA-salt) hypertensive rats is associated with mechanical modifications of blood vessels and (or) changes in tissular production and (or) vasoconstrictor activity to endothelin-1. Magnesium 84-86 endothelin 1 Rattus norvegicus 309-321 12117304-9 2002 Magnesium supplementation normalizes the altered vasoconstrictor activity of endothelin-1 in mesenteric arteries and attenuates endothelin-1 overproduction in kidney, left ventricle, and aorta of DOCA-salt rats. Magnesium 0-9 endothelin 1 Rattus norvegicus 77-89 12117304-9 2002 Magnesium supplementation normalizes the altered vasoconstrictor activity of endothelin-1 in mesenteric arteries and attenuates endothelin-1 overproduction in kidney, left ventricle, and aorta of DOCA-salt rats. Magnesium 0-9 endothelin 1 Rattus norvegicus 128-140 12117304-10 2002 These findings suggest that Mg supplementation prevents blood pressure elevation by attenuating peripheral resistance and by decreasing hypertrophic effect of endothelin-1 via inhibition of endothelin-1 production. Magnesium 28-30 endothelin 1 Rattus norvegicus 159-171 12117304-10 2002 These findings suggest that Mg supplementation prevents blood pressure elevation by attenuating peripheral resistance and by decreasing hypertrophic effect of endothelin-1 via inhibition of endothelin-1 production. Magnesium 28-30 endothelin 1 Rattus norvegicus 190-202 12052182-0 2002 Driving in vitro selection of anti-HIV-1 TAR aptamers by magnesium concentration and temperature. Magnesium 57-66 RNA binding motif protein 8A Homo sapiens 41-44 12052182-4 2002 Selections performed with a DNA library under low (4 degrees C, 10 mM magnesium) and high stringency (23 degrees C, 3 mM magnesium) led to the emergence of "kissing aptamers"; but even if the motif interacting directly with the TAR loop were identical in the two kinds of aptamers, the consensus was extended from eight to thirteen nucleotides when the Mg(2+) concentration was decreased from 10 to 3 mM. Magnesium 70-79 RNA binding motif protein 8A Homo sapiens 228-231 12052182-4 2002 Selections performed with a DNA library under low (4 degrees C, 10 mM magnesium) and high stringency (23 degrees C, 3 mM magnesium) led to the emergence of "kissing aptamers"; but even if the motif interacting directly with the TAR loop were identical in the two kinds of aptamers, the consensus was extended from eight to thirteen nucleotides when the Mg(2+) concentration was decreased from 10 to 3 mM. Magnesium 121-130 RNA binding motif protein 8A Homo sapiens 228-231 12106898-5 2002 It agglutinates native and trypsinized, papainized and neuraminidase-treated human A, B, O, AB and sheep erythrocytes, and the hemagglutinating activity is independent of Ca(2+), Mn(2+) and Mg(2+) ions; D-galactose and N-acetyl-D-galactosamine are found to be moderate inhibitors of the activity. Magnesium 190-192 neuraminidase 1 Homo sapiens 55-68 12067409-6 2002 Treatment of the cells with actinomycin D inhibited IL-6 expression in response to MG-132, suggesting the transcriptional upregulation of IL-6 under proteasomal inhibition. Magnesium 83-85 interleukin 6 Homo sapiens 52-56 12067409-6 2002 Treatment of the cells with actinomycin D inhibited IL-6 expression in response to MG-132, suggesting the transcriptional upregulation of IL-6 under proteasomal inhibition. Magnesium 83-85 interleukin 6 Homo sapiens 138-142 12050233-0 2002 A family of autosomal dominant hypocalcemia with a positive correlation between serum calcium and magnesium: identification of a novel gain of function mutation (Ser(820)Phe) in the calcium-sensing receptor. Magnesium 98-107 calcium sensing receptor Homo sapiens 182-206 12050233-14 2002 The positive correlation between serum calcium and magnesium levels observed in this family may support the concept that renal CaR acts as a magnesium sensor as well as a calcium sensor. Magnesium 51-60 calcium sensing receptor Homo sapiens 127-130 12050233-14 2002 The positive correlation between serum calcium and magnesium levels observed in this family may support the concept that renal CaR acts as a magnesium sensor as well as a calcium sensor. Magnesium 141-150 calcium sensing receptor Homo sapiens 127-130 12164088-0 2002 Relationship between the serum parathyroid hormone and magnesium levels in continuous ambulatory peritoneal dialysis (CAPD) patients using low-magnesium peritoneal dialysate. Magnesium 55-64 parathyroid hormone Homo sapiens 31-50 12164088-2 2002 Recently, it has been believed that magnesium plays an important role in regulating secretion of parathyroid hormone (PTH). Magnesium 36-45 parathyroid hormone Homo sapiens 97-116 12164088-2 2002 Recently, it has been believed that magnesium plays an important role in regulating secretion of parathyroid hormone (PTH). Magnesium 36-45 parathyroid hormone Homo sapiens 118-121 12164088-3 2002 The aim of this study was to evaluate the relationship between serum PTH and serum magnesium as a factor increasing the frequency of relative hypoparathyroidism. Magnesium 83-92 parathyroid hormone Homo sapiens 69-72 12070434-9 2002 Supine renin activity did not correlate with any parameters, whereas upright renin correlated with serum Mg and PTH. Magnesium 105-107 renin Homo sapiens 77-82 12032568-6 2002 The TRPM6 protein is a new member of the long transient receptor potential channel (TRPM) family and is highly similar to TRPM7 (also known as TRP-PLIK), a bifunctional protein that combines calcium- and magnesium-permeable cation channel properties with protein kinase activity. Magnesium 204-213 transient receptor potential cation channel subfamily M member 6 Homo sapiens 4-9 12032568-6 2002 The TRPM6 protein is a new member of the long transient receptor potential channel (TRPM) family and is highly similar to TRPM7 (also known as TRP-PLIK), a bifunctional protein that combines calcium- and magnesium-permeable cation channel properties with protein kinase activity. Magnesium 204-213 transient receptor potential cation channel subfamily M member 7 Homo sapiens 122-127 12032568-6 2002 The TRPM6 protein is a new member of the long transient receptor potential channel (TRPM) family and is highly similar to TRPM7 (also known as TRP-PLIK), a bifunctional protein that combines calcium- and magnesium-permeable cation channel properties with protein kinase activity. Magnesium 204-213 transient receptor potential cation channel subfamily M member 7 Homo sapiens 143-151 12032568-8 2002 These findings indicate that TRPM6 is crucial for magnesium homeostasis and implicate a TRPM family member in human disease. Magnesium 50-59 transient receptor potential cation channel subfamily M member 6 Homo sapiens 29-34 12046038-12 2002 Time-dependent PTH levels were associated with age, duration of dialysis, and levels of ionized calcium, phosphate, albumin, and magnesium. Magnesium 129-138 parathyroid hormone Homo sapiens 15-18 12046039-10 2002 Serum intact PTH levels correlated negatively with serum calcium (Ca) and magnesium (Mg) levels and positively with alkaline phosphatase levels in simple regression analysis. Magnesium 74-83 parathyroid hormone Homo sapiens 13-16 12046039-10 2002 Serum intact PTH levels correlated negatively with serum calcium (Ca) and magnesium (Mg) levels and positively with alkaline phosphatase levels in simple regression analysis. Magnesium 85-87 parathyroid hormone Homo sapiens 13-16 12046039-11 2002 However, in forward stepwise multiple regression analysis, only serum Ca and Mg levels predicted serum intact PTH levels. Magnesium 77-79 parathyroid hormone Homo sapiens 110-113 12358141-7 2002 SBP and DBP tended to be negatively associated with 24 h urinary potassium (K) and magnesium (Mg) excretion. Magnesium 94-96 selenium binding protein 1 Homo sapiens 0-3 12358141-7 2002 SBP and DBP tended to be negatively associated with 24 h urinary potassium (K) and magnesium (Mg) excretion. Magnesium 94-96 D-box binding PAR bZIP transcription factor Homo sapiens 8-11 11850416-4 2002 To understand how changes in iron and magnesium might affect the pathophysiology of Parkinson"s disease, we investigated binding of iron to alpha-synuclein, which accumulates in Lewy bodies. Magnesium 38-47 synuclein alpha Homo sapiens 140-155 12009891-1 2002 We report the 2.1 A crystal structure of the core G protein domain of the unusual Rho family member RhoE/Rnd3 in complex with endogenous GTP and magnesium. Magnesium 145-154 Rho family GTPase 3 Homo sapiens 105-109 11948788-5 2002 Further, two different magnesium-binding sites in parvalbumin and calbindin(D9K) can also be identified using an octahedral geometry. Magnesium 23-32 calbindin 1 Homo sapiens 66-79 11850416-0 2002 Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein. Magnesium 0-9 synuclein alpha Homo sapiens 63-78 11850416-5 2002 Using fluorescence of the four tyrosines in alpha-synuclein as indicators of metal-related conformational changes in alpha-synuclein, we show that iron and magnesium both interact with alpha-synuclein. Magnesium 156-165 synuclein alpha Homo sapiens 44-59 11850416-5 2002 Using fluorescence of the four tyrosines in alpha-synuclein as indicators of metal-related conformational changes in alpha-synuclein, we show that iron and magnesium both interact with alpha-synuclein. Magnesium 156-165 synuclein alpha Homo sapiens 117-132 11850416-5 2002 Using fluorescence of the four tyrosines in alpha-synuclein as indicators of metal-related conformational changes in alpha-synuclein, we show that iron and magnesium both interact with alpha-synuclein. Magnesium 156-165 synuclein alpha Homo sapiens 117-132 11850416-7 2002 Iron lowers both fluorescence peaks, while magnesium increases the fluorescence peak only at 375 nm, which suggests that magnesium affects the conformation of alpha-synuclein differently than iron. Magnesium 43-52 synuclein alpha Homo sapiens 159-174 11850416-7 2002 Iron lowers both fluorescence peaks, while magnesium increases the fluorescence peak only at 375 nm, which suggests that magnesium affects the conformation of alpha-synuclein differently than iron. Magnesium 121-130 synuclein alpha Homo sapiens 159-174 11850416-8 2002 Consistent with this hypothesis, we also observe that magnesium inhibits alpha-synuclein aggregation, measured by immunoblot, cellulose acetate filtration, or thioflavine-T fluorescence. Magnesium 54-63 synuclein alpha Homo sapiens 73-88 11850416-9 2002 In each of these studies, iron increases alpha-synuclein aggregation, while magnesium at concentrations >0.75 mm inhibits the aggregation of alpha-synuclein induced either spontaneously or by incubation with iron. Magnesium 76-85 synuclein alpha Homo sapiens 144-159 11850416-10 2002 These data suggest that the conformation of alpha-synuclein can be modulated by metals, with iron promoting aggregation and magnesium inhibiting aggregation. Magnesium 124-133 synuclein alpha Homo sapiens 44-59 11812784-5 2002 The kinetic mechanism of ERK2 was examined, with excess magnesium, by initial velocity measurements, both in the absence and presence of products at 27 degrees C, pH 7.5, and ionic strength 0.1 m (KCl). Magnesium 56-65 mitogen-activated protein kinase 1 Homo sapiens 25-29 12001011-1 2002 BACKGROUND: Magnesium deficiency is common in type 2 diabetes and may have a negative impact on glucose homeostasis and insulin resistance, as well as on the evolution of complications such as retinopathy, thrombosis and hypertension. Magnesium 12-21 insulin Homo sapiens 120-127 12073040-3 2002 Tobacco topoisomerase I was over-expressed in Escherichia coli, and the purified recombinant protein was found to relax both positively and negatively super-coiled DNA in the absence of the divalent cation Mg(2+)and ATP. Magnesium 206-208 DNA topoisomerase 1-like Nicotiana tabacum 8-23 11969398-6 2002 The additional effect of magnesium on 3DEF4, observed in the absence or presence of 100 mM KCl, is attributed to a nonspecific but high-affinity site for metal ions created by a region of unusual high charge density. Magnesium 25-34 defensin alpha 4 Homo sapiens 39-43 11969404-6 2002 Studies on the isolated recombinant N- (N-CLSP) and C-terminal half domains of CLSP (C-CLSP) revealed that, in contrast to the case of TNC, the high-affinity Ca(2+)-Mg(2+) mixed sites reside in the N-terminal half. Magnesium 165-167 calmodulin like 5 Homo sapiens 79-83 11969404-6 2002 Studies on the isolated recombinant N- (N-CLSP) and C-terminal half domains of CLSP (C-CLSP) revealed that, in contrast to the case of TNC, the high-affinity Ca(2+)-Mg(2+) mixed sites reside in the N-terminal half. Magnesium 165-167 calmodulin like 5 Homo sapiens 85-91 12075573-0 2002 Relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects. Magnesium 27-36 C-reactive protein Homo sapiens 48-66 11942673-7 2002 Mean percentages of the individual components in MIG/Al fumes/dusts were Al: 30 (9-56) percent; Mg: 3 (1-5.6) percent; Mn: 0.2 (0.1-0.3) percent; Cu: 0.2 (< 0.1-1.8) percent; Zn: 0.2 (< 0.1-0.8) percent; Pb: 0.2 (< 0.1-1) percent; Cr: < 0.1 percent. Magnesium 96-98 C-X-C motif chemokine ligand 9 Homo sapiens 49-52 12075573-9 2002 Twenty-three (82.1%) of the subjects with low serum magnesium (five overweight and 18 obese) showed CRP concentration equal or more than 10 mg/l. Magnesium 52-61 C-reactive protein Homo sapiens 100-103 12075573-10 2002 There was a graded significant decrease between CRP concentration and serum magnesium levels (r = -0.39, P = 0.002). Magnesium 76-85 C-reactive protein Homo sapiens 48-51 12075573-12 2002 CONCLUSION: The results of this study show that low serum magnesium levels are independently related to elevated CRP concentration, in non-diabetic, non-hypertensive obese subjects. Magnesium 58-67 C-reactive protein Homo sapiens 113-116 12075573-1 2002 OBJECTIVE: To examine the association between serum magnesium levels and C-reactive protein (CRP) in non-diabetic, non-hypertensive obese subjects. Magnesium 52-61 C-reactive protein Homo sapiens 73-91 12075573-1 2002 OBJECTIVE: To examine the association between serum magnesium levels and C-reactive protein (CRP) in non-diabetic, non-hypertensive obese subjects. Magnesium 52-61 C-reactive protein Homo sapiens 93-96 11920952-7 2002 The ecto-enzyme is bound to the prostasome-membranes through a GPI-anchor and is activated by physiological concentration of Ca+2, Mg+2, and Mn+2. Magnesium 131-133 tripartite motif containing 33 Homo sapiens 4-8 11900549-0 2002 Pentavalent ions dependency is a conserved property of adenosine kinase from diverse sources: identification of a novel motif implicated in phosphate and magnesium ion binding and substrate inhibition. Magnesium 154-163 adenosine kinase Homo sapiens 55-71 11788589-4 2002 DREAM binds 1 mol of magnesium/mol of protein. Magnesium 21-30 potassium voltage-gated channel interacting protein 3 Homo sapiens 0-5 11788589-5 2002 DREAM, pre-loaded with 1 mol of calcium, binds 1 mol of magnesium, thus demonstrating that the magnesium-binding site is distinct from the high affinity calcium-binding site. Magnesium 56-65 potassium voltage-gated channel interacting protein 3 Homo sapiens 0-5 11788589-5 2002 DREAM, pre-loaded with 1 mol of calcium, binds 1 mol of magnesium, thus demonstrating that the magnesium-binding site is distinct from the high affinity calcium-binding site. Magnesium 95-104 potassium voltage-gated channel interacting protein 3 Homo sapiens 0-5 11788589-6 2002 Analysis of metal binding to mutant DREAM protein constructs localizes the high affinity calcium-binding site and the magnesium-binding site to EF-hands 3 or 4. Magnesium 118-127 potassium voltage-gated channel interacting protein 3 Homo sapiens 36-41 11788589-9 2002 We conclude that DREAM binds calcium and magnesium and that calcium, but not magnesium, modulates DREAM structure and function. Magnesium 41-50 potassium voltage-gated channel interacting protein 3 Homo sapiens 17-22 11777934-12 2002 Finally, GCA is exclusively membrane-bound and is active mainly with Mg(2+), whereas sGC is predominantly soluble and more active with Mn(2+). Magnesium 69-71 grancalcin Homo sapiens 9-12 11773072-4 2002 In the presence of Ca(2+) and Mg(2+), LBP and BPI each promote aggregation of LPS to protein-LPS aggregates of increased size (apparent M(r) > 20 x 10(6) Da), but only LPS associated with LBP and BPI(N)-LBP(C) is disaggregated in the presence of CD14. Magnesium 30-32 lipopolysaccharide binding protein Homo sapiens 38-41 11773072-4 2002 In the presence of Ca(2+) and Mg(2+), LBP and BPI each promote aggregation of LPS to protein-LPS aggregates of increased size (apparent M(r) > 20 x 10(6) Da), but only LPS associated with LBP and BPI(N)-LBP(C) is disaggregated in the presence of CD14. Magnesium 30-32 bactericidal permeability increasing protein Homo sapiens 46-49 11866606-1 2002 The interaction between biotin and the macrocyclic magnesium complex Mg(15-crown-5)(Otf)2 (15-crown-5 is 1,4,7,10,13-pentaoxacyclopentadecane, Otf(-) is trifluoromethanesulfonate anion) in solution was studied as a model for metal-biotin interactions that may be important in its speciation and function. Magnesium 51-60 POU class 2 homeobox 2 Homo sapiens 84-89 11873045-0 2002 Extracellular magnesium ion modifies the actions of volatile anesthetics in area CA1 of rat hippocampus in vitro. Magnesium 14-23 carbonic anhydrase 1 Rattus norvegicus 81-84 11883897-4 2002 VRK1 uses preferentially magnesium, but is also functional with manganese and zinc. Magnesium 25-34 VRK serine/threonine kinase 1 Homo sapiens 0-4 11836293-1 2002 Isolated hereditary renal magnesium (Mg) wasting may result from mutations in the renal tubular epithelial cell tight junction protein paracellin-1 gene or the tubular Na(+),K(+)-ATPase gamma-subunit gene FXYD2. Magnesium 26-35 claudin 16 Homo sapiens 135-147 11836293-1 2002 Isolated hereditary renal magnesium (Mg) wasting may result from mutations in the renal tubular epithelial cell tight junction protein paracellin-1 gene or the tubular Na(+),K(+)-ATPase gamma-subunit gene FXYD2. Magnesium 37-39 claudin 16 Homo sapiens 135-147 11836293-1 2002 Isolated hereditary renal magnesium (Mg) wasting may result from mutations in the renal tubular epithelial cell tight junction protein paracellin-1 gene or the tubular Na(+),K(+)-ATPase gamma-subunit gene FXYD2. Magnesium 37-39 FXYD domain containing ion transport regulator 2 Homo sapiens 205-210 12503612-10 2002 The crystal structure of PDE4 contains magnesium and zinc cations as well as catalytic water molecule but no ligand. Magnesium 39-48 phosphodiesterase 4A Homo sapiens 25-29 11751015-7 2002 There were gender differences in NR2A subunit mRNA expression in the hippocampal CA3 region in the Mg and Pb groups, but combining the three metals in the full concentration showed no gender effect. Magnesium 99-101 glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus 33-37 11805316-3 2002 In the second, magnesium ion-dependent reaction, diphosphate ester ionization-initiated cyclization generates the tricyclic perhydrophenanthrene-type backbone and is coupled, by intramolecular proton transfer within a transient pimarenyl intermediate, to a 1,2-methyl migration that generates the C13 isopropyl group characteristic of the abietane structure. Magnesium 15-24 homeobox C13 Homo sapiens 297-300 11880175-0 2002 Modulation of cyclin-dependent kinase 4 by binding of magnesium (II) and manganese (II). Magnesium 54-63 cyclin dependent kinase 4 Homo sapiens 14-39 11880175-6 2002 The inhibition constants for the inhibition of CDK4 by MgADP and a small molecule inhibitor were also perturbed by Mg(2+). Magnesium 55-57 cyclin dependent kinase 4 Homo sapiens 47-51 11880175-11 2002 However, the affinities of small molecule inhibitors for CDK4 were not affected by the change of metal from Mg(2+) to Mn(2+), suggesting that the structures of enzyme-Mg(2+) and enzyme-Mn(2+) were similar. Magnesium 108-110 cyclin dependent kinase 4 Homo sapiens 57-61 14601471-6 2002 Significantly lower total magnesium concentrations were demonstrated in hair of patients receiving ACE inhibitors and diuretics in comparison to controls. Magnesium 26-35 angiotensin I converting enzyme Homo sapiens 99-102 11867433-0 2002 Molecular mechanisms of calcium and magnesium binding to parvalbumin. Magnesium 36-45 parvalbumin Homo sapiens 57-68 11927263-3 2002 We have determined the crystal structure of RhoA.GDP bound to RhoGAP in the presence of Mg(2+) and F(-) but without Al(3+). Magnesium 88-90 ras homolog family member A Homo sapiens 44-48 11927263-3 2002 We have determined the crystal structure of RhoA.GDP bound to RhoGAP in the presence of Mg(2+) and F(-) but without Al(3+). Magnesium 88-90 Rho GTPase activating protein 1 Homo sapiens 62-68 11940055-4 2002 The patient had impaired parathormone (PTH) responsiveness to peripheral stimuli, as proved by the marked PTH increase and normalization of plasma calcium levels after acute and chronic administration of magnesium salts. Magnesium 204-213 parathyroid hormone Homo sapiens 39-42 11940055-4 2002 The patient had impaired parathormone (PTH) responsiveness to peripheral stimuli, as proved by the marked PTH increase and normalization of plasma calcium levels after acute and chronic administration of magnesium salts. Magnesium 204-213 parathyroid hormone Homo sapiens 106-109 11922699-4 2002 IgG secretion was, however, correlated with the secretions of IL-5 and IL-6 in MG. Magnesium 79-81 interleukin 5 Homo sapiens 62-66 11922699-4 2002 IgG secretion was, however, correlated with the secretions of IL-5 and IL-6 in MG. Magnesium 79-81 interleukin 6 Homo sapiens 71-75 12030421-1 2002 We investigated the level of low density lipoprotein receptors (LDLR) in fibroblasts upon treatment with low magnesium and/or cholestane-3beta, 5alpha, 6beta-triol (TriolC). Magnesium 109-118 low density lipoprotein receptor Homo sapiens 29-62 12030421-1 2002 We investigated the level of low density lipoprotein receptors (LDLR) in fibroblasts upon treatment with low magnesium and/or cholestane-3beta, 5alpha, 6beta-triol (TriolC). Magnesium 109-118 low density lipoprotein receptor Homo sapiens 64-68 12030421-2 2002 After 72 h of incubation with low magnesium at a level of 188 micromol or lower, the LDLR levels, determined with immunoblotting analysis, were significantly reduced in the cultured cells. Magnesium 34-43 low density lipoprotein receptor Homo sapiens 85-89 12030421-5 2002 Our results showed that both low magnesium concentration and TriolC reduced the LDLR level, but the reducing effect was not accentuated when both were present in the culture medium. Magnesium 33-42 low density lipoprotein receptor Homo sapiens 80-84 12030423-4 2002 Moreover, neutrophils activated with fMLP showed an increased respiratory burst when incubated in low Mg concentration (0.2 mmol/l) as compared to normal Mg concentration (0.8 mmol/l). Magnesium 102-104 formyl peptide receptor 1 Homo sapiens 37-41 11861917-0 2002 Magnesium is required for specific DNA binding of the CREB B-ZIP domain. Magnesium 0-9 cAMP responsive element binding protein 1 Homo sapiens 54-58 11861917-0 2002 Magnesium is required for specific DNA binding of the CREB B-ZIP domain. Magnesium 0-9 death associated protein kinase 3 Homo sapiens 61-64 11861917-11 2002 The magnesium concentration needed to prevent non-specific electrostatic interactions between CREB and DNA in solution is in the physiological range and thus changes in magnesium concentration may be a cellular signal that regulates gene expression. Magnesium 4-13 cAMP responsive element binding protein 1 Homo sapiens 94-98 11861917-11 2002 The magnesium concentration needed to prevent non-specific electrostatic interactions between CREB and DNA in solution is in the physiological range and thus changes in magnesium concentration may be a cellular signal that regulates gene expression. Magnesium 169-178 cAMP responsive element binding protein 1 Homo sapiens 94-98 11939546-0 2002 Role of the magnesium cation on antihypertensive molecule-human serum albumin binding: affinity chromatography approach. Magnesium 12-21 albumin Homo sapiens 64-77 11893344-8 2002 While this dissociation of renal calcium and magnesium handling was also observed in some ClC-Kb patients, a few ClC-Kb patients presented with hypercalciuria and hypo- or isosthenuria. Magnesium 45-54 chloride voltage-gated channel Kb Homo sapiens 90-96 11884928-11 2002 Magnesium supplementation also improved glomerular dysfunction, at least in part, through inhibition of up-regulated mRNA of endothelin-1. Magnesium 0-9 endothelin 1 Homo sapiens 125-137 11886258-3 2002 The divalent cation requirement for this activity of e sigma A was further examined by the addition of Mn(2+), Mg(2+), Ca(2+), and Zn(2+) ions. Magnesium 111-113 sigma-A protein Avian orthoreovirus 55-62 11886258-7 2002 The results suggest that nucleotidyl phosphatase activity of e sigma A is absolutely dependent on the divalent cations Mn(2+), Mg(2+), or Ca(2+), but not Zn(2+). Magnesium 127-129 sigma-A protein Avian orthoreovirus 63-70 11895162-5 2002 Higher plasma interleukin 6 and NO concentrations and increased lipid peroxidation in the heart were found in Mg-deficient rats as compared with control rats. Magnesium 110-112 interleukin 6 Rattus norvegicus 14-27 11858544-11 2002 CONCLUSIONS: In MOCOD we found abnormal accumulation of sulphur and magnesium in neurons. Magnesium 68-77 molybdenum cofactor synthesis 1 Homo sapiens 16-21 11858544-12 2002 It is postulated that sulphur-containing compound(s) that are formed as a result of MOCOD cause excitotoxic neuronal injury in the presence of excess magnesium. Magnesium 150-159 molybdenum cofactor synthesis 1 Homo sapiens 84-89 11937868-3 2002 The bone mineral idealized as calcium hydroxyapatite, Ca10 (PO4)(6)(OH)2, is a carbonatehydroxyapatite, approximated by the formula: (Ca,X)(10)(PO4,HPO4,CO3)(6)(OH,Y)2, where X are cations (magnesium, sodium, strontium ions) that can substitute for the calcium ions, and Y are anions (chloride or fluoride ions) that can substitute for the hydroxyl group. Magnesium 190-199 carbonic anhydrase 10 Homo sapiens 54-58 11856348-5 2002 In vitro kinase assays showed that the autophosphorylating ability of PknA is strictly magnesium/manganese-dependent, and sodium orthovanadate can inhibit this activity. Magnesium 87-96 serine/threonine-protein kinase PknA Mycobacterium tuberculosis H37Rv 70-74 11866606-11 2002 These can serve to organize cofactor interactions with biomolecules, as was recently demonstrated for a biotin-selective RNA aptamer that depends on a direct biotin-magnesium interaction for recognition of biotin (Nix, J.; Sussman, D.; Wilson, C. J. Mol. Magnesium 165-174 BCL2 interacting protein 3 like Homo sapiens 214-217 11994563-0 2002 Magnesium and manganese ions accelerate tissue factor-induced coagulation independently of factor IX. Magnesium 0-9 coagulation factor III, tissue factor Homo sapiens 40-53 12495258-1 2002 The aim of this study was to investigate the impact of magnesium-enriched, high-calcium milk on serum parathyroid hormone (PTH) and biochemical markers of bone turnover in postmenopausal women. Magnesium 55-64 parathyroid hormone Homo sapiens 102-121 11866106-0 2002 Changes in N-acetyl-beta-D-glucosaminidase activity in the urine and urinary albumin excretion in magnesium deficient rats. Magnesium 98-107 O-GlcNAcase Rattus norvegicus 11-42 11866106-2 2002 NAG activity in the urine and urinary albumin excretion in rats fed the Mg-deficient diet significantly increased from 7 d until the end of the feeding period. Magnesium 72-74 O-GlcNAcase Rattus norvegicus 0-3 11994563-1 2002 The purpose of the present study was to assess the effect of magnesium and manganese ions on tissue factor (TF)-induced coagulation and the possible role of factor IX therein. Magnesium 61-70 coagulation factor III, tissue factor Homo sapiens 93-106 11751022-6 2002 Both ANP and BNP levels were significantly higher in infants with antenatal magnesium administration than in those without. Magnesium 76-85 natriuretic peptide B Homo sapiens 13-16 11994563-1 2002 The purpose of the present study was to assess the effect of magnesium and manganese ions on tissue factor (TF)-induced coagulation and the possible role of factor IX therein. Magnesium 61-70 coagulation factor III, tissue factor Homo sapiens 108-110 11994563-3 2002 At higher concentrations, magnesium and manganese prolonged the TF-induced coagulation time. Magnesium 26-35 coagulation factor III, tissue factor Homo sapiens 64-66 11994563-5 2002 Shortening of the TF-induced coagulation time by magnesium and manganese was also observed in factor IX-deficient plasma. Magnesium 49-58 coagulation factor III, tissue factor Homo sapiens 18-20 11744609-3 2002 hFMO2.1 also retained significantly more activity than mFMO2 did in the presence of magnesium and all detergents tested. Magnesium 84-93 flavin containing monooxygenase 2 Mus musculus 55-60 11873239-0 2002 Effects of interleukin 2 therapy on lymphocyte magnesium levels. Magnesium 47-56 interleukin 2 Homo sapiens 11-24 12415617-4 2002 The present investigation demonstrated that IL-1 alpha dramatically increased the sensitivity of MG-63, SAOS-2, and TE-85 osteosarcoma cells to etoposide when the two agents were used simultaneously. Magnesium 97-99 interleukin 1 alpha Homo sapiens 44-54 11873239-2 2002 Among the many physiologic effects of IL-2, decreased serum levels of the divalent cations magnesium (Mg) and calcium have been demonstrated, with corresponding decreases in their urinary excretion. Magnesium 91-100 interleukin 2 Homo sapiens 38-42 11873239-2 2002 Among the many physiologic effects of IL-2, decreased serum levels of the divalent cations magnesium (Mg) and calcium have been demonstrated, with corresponding decreases in their urinary excretion. Magnesium 102-104 interleukin 2 Homo sapiens 38-42 11873239-3 2002 We investigated the effect of IL-2 on lymphocyte Mg levels among patients receiving three different dosing regimens. Magnesium 49-51 interleukin 2 Homo sapiens 30-34 11873239-10 2002 During IL-2 therapy, lymphocyte Mg increases coincident with serum Mg depletion. Magnesium 32-34 interleukin 2 Homo sapiens 7-11 11873239-10 2002 During IL-2 therapy, lymphocyte Mg increases coincident with serum Mg depletion. Magnesium 67-69 interleukin 2 Homo sapiens 7-11 11863398-3 2002 After thoroughly researching the literature, I hypothesize that magnesium deficiency may be the central precipitating event and common pathway for the subsequent biochemical effects on substance P, kynurenine, NMDA receptors, and vitamin B6 that may result in the symptomatology of Tourette"s syndrome and several reported comorbid conditions. Magnesium 64-73 tachykinin precursor 1 Homo sapiens 185-196 12511185-0 2002 Does magnesium dysbalance participate in the development of insulin resistance in early stages of renal disease? Magnesium 5-14 insulin Homo sapiens 60-67 12382871-1 2002 L3PO4:Mg,Cu, a low effective atomic number and high sensitivity TSL phosphor, has been prepared. Magnesium 6-8 TSL Homo sapiens 64-67 12382893-0 2002 Analysis of the glow curves obtained from LiF:Mg,Cu,Na,Si TL material using the general order kinetics model. Magnesium 46-48 LIF interleukin 6 family cytokine Homo sapiens 42-45 12382893-4 2002 The glow curves of LiF:Mg,Cu,Na,Si TL material were deconvoluted to six isolated glow curves which have peak temperatures at 333, 374, 426, 466, 483 and 516 K. The main glow peak of peak temperature at 466 K had activation energy of 2.06 eV and a kinetic order of 1.05. Magnesium 23-25 LIF interleukin 6 family cytokine Homo sapiens 19-22 12382908-4 2002 This presentation gives a comprehensive survey of the spectral and dose dependent RL properties of a number of luminescent materials like LiF:Mg,Ti, Al2O3:C, CaSO4:Dy, CaF2:Mn, Li2B4O7:Mn, BeO and ZnS:Ag. Magnesium 142-144 LIF interleukin 6 family cytokine Homo sapiens 138-141 12382919-0 2002 TL emission spectra from differently doped LiF:Mg detectors. Magnesium 47-49 LIF interleukin 6 family cytokine Homo sapiens 43-46 12382923-0 2002 Thermoluminescence properties of LiF:Mg,Cu,Na,Si pellets in radiation dosimetry. Magnesium 37-39 LIF interleukin 6 family cytokine Homo sapiens 33-36 12382923-1 2002 Sintered LiF:Mg,Cu,Na,Si thermoluminescence (TL) pellets have been developed for application in radiation dosimetry. Magnesium 13-15 LIF interleukin 6 family cytokine Homo sapiens 9-12 12382923-5 2002 In the present study, the physical and dosimetric properties of LiF:Mg,Cu,Na,Si TL pellets were investigated for their emission spectrum, dose response, energy response and fading characteristics. Magnesium 68-70 LIF interleukin 6 family cytokine Homo sapiens 64-67 11896316-9 2002 In PAS-2 modified (PAS-2 with 1.5 mmol/L Mg(2+) and 4.5 mmol/L K(+)) and CPD plasma, the corresponding CD62 values were 23 and 35 percent, respectively. Magnesium 41-43 glycophorin C (Gerbich blood group) Homo sapiens 19-24 11733986-0 2001 Three-dimensional structures of the Mn and Mg dTDP complexes of the family GT-2 glycosyltransferase SpsA: a comparison with related NDP-sugar glycosyltransferases. Magnesium 43-45 TAR DNA-binding protein-43 homolog Drosophila melanogaster 46-50 11729235-1 2001 The novel member of the claudin multigene family, paracellin-1/claudin-16, encoded by the gene PCLN1, is a renal tight junction protein that is involved in the paracellular transport of magnesium and calcium in the thick ascending limb of Henle"s loop. Magnesium 186-195 claudin 16 Mus musculus 50-62 11729235-1 2001 The novel member of the claudin multigene family, paracellin-1/claudin-16, encoded by the gene PCLN1, is a renal tight junction protein that is involved in the paracellular transport of magnesium and calcium in the thick ascending limb of Henle"s loop. Magnesium 186-195 claudin 16 Mus musculus 63-73 11729235-1 2001 The novel member of the claudin multigene family, paracellin-1/claudin-16, encoded by the gene PCLN1, is a renal tight junction protein that is involved in the paracellular transport of magnesium and calcium in the thick ascending limb of Henle"s loop. Magnesium 186-195 claudin 16 Mus musculus 95-100 11729235-2 2001 Mutations in human PCLN1 are associated with familial hypomagnesemia with hypercalciuria and nephrocalcinosis, an autosomal recessive disease that is characterized by severe renal magnesium and calcium loss. Magnesium 180-189 claudin 16 Homo sapiens 19-24 11735085-0 2001 Magnesium reduces insulin-stimulated glucose uptake and serum lipid concentrations in type 1 diabetes. Magnesium 0-9 insulin Homo sapiens 18-25 11735085-5 2001 Acute and chronic Mg supplementation decreased serum total cholesterol, serum low-density lipoprotein (LDL)-cholesterol, and apolipoprotein B. Magnesium 18-20 apolipoprotein B Homo sapiens 125-141 11735085-10 2001 Mg repletion was associated with a decrease in atherogenic lipid fractions and a reduced insulin-stimulated glucose uptake. Magnesium 0-2 insulin Homo sapiens 89-96 11752386-4 2001 One member of this family, AtMGT1, functionally complemented a bacterial mutant lacking Mg(2+) transport capability. Magnesium 88-90 magnesium transporter 1 Arabidopsis thaliana 27-33 11752386-6 2001 (63)Ni tracer studies in bacteria showed that AtMGT1 has highest affinity for Mg(2+) but may also be capable of transporting several other divalent cations, including Ni(2+), Co(2+), Fe(2+), Mn(2+), and Cu(2+). Magnesium 78-80 magnesium transporter 1 Arabidopsis thaliana 46-52 11706089-3 2001 OBJECTIVE: To re-evaluate the association of HLA with MG in 656 patients with generalized disease and to test linkage of HLA to MG with thymus hyperplasia. Magnesium 54-56 major histocompatibility complex, class II, DR beta 1 Homo sapiens 45-48 11771283-2 2001 Based on the analysis of curves of fluorescence quenching of FITC-labeled Ca-ATPase by Nd3+ ions, the parameters characterizing the structural changes in the Mg-ATP binding center were determined. Magnesium 158-160 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 87-90 11684180-3 2001 The three isozymes could be distinguished from one another with respect to response to fructose, Mg and nucleotide donor concentrations and this allowed the comparison of the fruit enzymes with the gene products of the two known cloned tomato fructokinase genes, LeFRK1 and LeFRK2. Magnesium 97-99 fructokinase Solanum lycopersicum 243-255 11598397-4 2001 Increases were observed in urinary excretions of Ca and Mg associated with a reduction in the PTH level in rats treated with 3 or 5% sevelamer. Magnesium 56-58 parathyroid hormone Rattus norvegicus 94-97 11704205-5 2001 When magnesium was discontinued, her vitamin D-1,25 was suppressed and the parathyroid hormone was elevated. Magnesium 5-14 parathyroid hormone Homo sapiens 75-94 11514570-6 2001 An RNA substrate containing the tumor necrosis factor alpha ARE displayed a weak conformational transition in the absence of added cations but was cooperatively stabilized by Mg(2+). Magnesium 175-177 tumor necrosis factor Homo sapiens 32-59 11574461-4 2001 Furthermore, the residues that usually co-ordinate Mg(2+) through water molecules in the GTP-binding proteins, though conserved in SsEF-1alpha, are located quite far from the binding site. Magnesium 51-53 ribosomal protein S18-alanine N-acetyltransferase Saccharolobus solfataricus 131-142 11546677-7 2001 These findings suggest that in vivo downregulation of K-Cl cotransport activity by Mg is mediated by enhanced Src family kinase activity, leading to inhibition of the K-Cl cotransport stimulator PP1. Magnesium 83-85 protein phosphatase 1 catalytic subunit gamma Mus musculus 195-198 11566777-6 2001 Thus, the reduced Mg(2+) inhibition of the MHS RyR1 compared with the normal RyR1 is due to both an enhanced selectivity of the MHS RyR1 A-site for Ca(2+) over Mg(2+) and a reduced Mg(2+) affinity of the I-site. Magnesium 18-20 ryanodine receptor 1 Homo sapiens 47-51 11585706-5 2001 Further, a modest inhibitory effect of the neurokinin-1 receptor antagonist, spantide, suggested that factors acting via neurokinin-1 receptors may partly modulate cardiac fibroblast function in magnesium deficiency. Magnesium 195-204 tachykinin receptor 1 Rattus norvegicus 43-64 11562470-7 2001 Nucleotide binding to BCK is uniquely mediated by both potassium and magnesium. Magnesium 69-78 creatine kinase B Rattus norvegicus 22-25 11566941-1 2001 Previous studies by our group have identified ionic aspects of insulin resistance in hypertension, in which cellular responses to insulin were influenced by the basal intracellular ionic environment-the lower the cytosolic free magnesium (Mg(i)), the less Mg(i) increased following insulin stimulation. Magnesium 228-237 insulin Homo sapiens 63-70 11544180-3 2001 Here we show that mutant alleles of the MRS2 gene as well as overexpression of this gene both increase intramitochondrial Mg(2+) concentrations and compensate for splicing defects of group II introns in mit(-) mutants M1301 and B-loop. Magnesium 122-124 Mrs2p Saccharomyces cerevisiae S288C 40-44 11566941-1 2001 Previous studies by our group have identified ionic aspects of insulin resistance in hypertension, in which cellular responses to insulin were influenced by the basal intracellular ionic environment-the lower the cytosolic free magnesium (Mg(i)), the less Mg(i) increased following insulin stimulation. Magnesium 228-237 insulin Homo sapiens 130-137 11566941-1 2001 Previous studies by our group have identified ionic aspects of insulin resistance in hypertension, in which cellular responses to insulin were influenced by the basal intracellular ionic environment-the lower the cytosolic free magnesium (Mg(i)), the less Mg(i) increased following insulin stimulation. Magnesium 228-237 insulin Homo sapiens 130-137 11566960-0 2001 Insulin-mimetic action of vanadate: role of intracellular magnesium. Magnesium 58-67 insulin Homo sapiens 0-7 11596855-8 2001 These are: 1) the regulation of intracellular Ca++ concentration by voltage-gated K+ channels, 2) the maintenance of normal RhoA levels that, with Rac, regulate the assembly of actin stress fibers, focal adhesions, and contractility, 3) the formation of ATP-Mg++-polyamine trimers that enhance the phosphorylation activity of ATP toward enzymes in specific signaling pathways and, 4) alterations in the structure of RNA that change translation initiation sites and affect the expression of proteins. Magnesium 258-262 ras homolog family member A Homo sapiens 124-128 11566960-2 2001 Although the exact mechanism(s) remain undefined, we have previously demonstrated a direct relation of intracellular free magnesium (Mg(i)) levels to glucose disposal, to insulinemic responses following glucose loading, and to insulin-induced ionic effects. Magnesium 122-131 insulin Homo sapiens 171-178 11520061-1 2001 Extracellular magnesium (Mg) depletion inhibits the growth of the HC11 normal mammary epithelial cells. Magnesium 14-23 C-C motif chemokine ligand 2 Homo sapiens 66-70 11520061-1 2001 Extracellular magnesium (Mg) depletion inhibits the growth of the HC11 normal mammary epithelial cells. Magnesium 25-27 C-C motif chemokine ligand 2 Homo sapiens 66-70 11520061-7 2001 Cell total Mg content was 19.6, 9.7, and 20.1 nmol/mg protein in the HC11, HC-LMg, and HC-HMg cells, respectively. Magnesium 11-13 C-C motif chemokine ligand 2 Homo sapiens 69-73 11506852-6 2001 Magnesium stimulated apoptosis within the physiologic range (0.8-1.2 mM) (n = 6, P <.001) and was associated with cleavage of plasminogen activator inhibitor type 2 and cytokeratin-18 neoepitope formation. Magnesium 0-9 keratin 18 Homo sapiens 172-186 11469868-0 2001 Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions. Magnesium 83-92 DNA topoisomerase II alpha Homo sapiens 51-61 11762702-6 2001 After 12-48 h of treatment, E2 at 10(-8)M decreased MMP-1 level in cultures of MG-63 cells or hOB. Magnesium 79-81 matrix metallopeptidase 1 Homo sapiens 52-57 12382860-3 2002 In the glow curve of LiF:Mg,Cu,P with a low concentration of Mg a new peak was found, which appears to be an analogue of peak 4 in LiF:Mg,Ti, Magnesium apparently controls most of the dosimetric properties of LiF-based phosphors. Magnesium 142-151 LIF interleukin 6 family cytokine Homo sapiens 21-24 12382860-3 2002 In the glow curve of LiF:Mg,Cu,P with a low concentration of Mg a new peak was found, which appears to be an analogue of peak 4 in LiF:Mg,Ti, Magnesium apparently controls most of the dosimetric properties of LiF-based phosphors. Magnesium 142-151 LIF interleukin 6 family cytokine Homo sapiens 131-134 12382860-3 2002 In the glow curve of LiF:Mg,Cu,P with a low concentration of Mg a new peak was found, which appears to be an analogue of peak 4 in LiF:Mg,Ti, Magnesium apparently controls most of the dosimetric properties of LiF-based phosphors. Magnesium 142-151 LIF interleukin 6 family cytokine Homo sapiens 131-134 12382860-6 2002 It is suggested that Ti hampers the acceptance of any increased amount of Mg into more traps in LiF:MgTi. Magnesium 74-76 LIF interleukin 6 family cytokine Homo sapiens 96-99 12382868-0 2002 A new high sensitivity thermoluminescent phosphor with low residual signal and good stability to heat treatment: LiF:Mg,Cu,Na,Si. Magnesium 117-119 LIF interleukin 6 family cytokine Homo sapiens 113-116 12382868-1 2002 The preliminary investigations are reported on the characteristics of a new, high-sensitivity thermoluminescence phosphor material (LiF:Mg,Cu,Na,Si) prepared in this laboratory. Magnesium 136-138 LIF interleukin 6 family cytokine Homo sapiens 132-135 12382868-7 2002 It retains the main advantages of LiF:Mg,Cu,P phosphor, and has a lower residual signal and a better stability to heat treatment. Magnesium 38-40 LIF interleukin 6 family cytokine Homo sapiens 34-37 11483714-13 2001 In high external potassium (K(+) 17.5 mM), nociceptin reduced the rate of miniature IPSCs in the presence (Ca(2+) 2.4 mM, Mg(2+) 1.2 mM) but not in the absence of external calcium (Ca(2+) 0 mM, Mg(2+) 10 mM, Cd(2+) 10 microM). Magnesium 122-124 prepronociceptin Rattus norvegicus 43-53 11483714-13 2001 In high external potassium (K(+) 17.5 mM), nociceptin reduced the rate of miniature IPSCs in the presence (Ca(2+) 2.4 mM, Mg(2+) 1.2 mM) but not in the absence of external calcium (Ca(2+) 0 mM, Mg(2+) 10 mM, Cd(2+) 10 microM). Magnesium 194-196 prepronociceptin Rattus norvegicus 43-53 11342562-7 2001 Outward currents generated by reverse NCKX2 exchange depended on external Ca(2+) with a K(12) of 1.4 or 101 microm without or with 1 mm Mg(2+), and on external K(+) with a K(1/2) of about 12 or 36 mm with choline or Li(+) as counter ion, respectively. Magnesium 136-138 solute carrier family 24 member 2 Rattus norvegicus 38-43 11423399-6 2001 In contrast with the high-affinity Zn inhibition of wild-type NR1/NR2A receptors, the high-affinity Zn inhibition of mutated NR1/NR2C receptors shows a voltage dependence, which resembles very much that of the block by extracellular Mg. Magnesium 233-235 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 125-128 11423479-8 2001 Furthermore, pretreatment of the cytosolic fraction with anti-PP2A serum attenuated the glutamate- and magnesium-mediated activation of ACC, thereby suggesting that ACC may be regulated by an OKA-sensitive PP2A-like enzyme. Magnesium 103-112 protein phosphatase 2 phosphatase activator Homo sapiens 62-66 11423479-8 2001 Furthermore, pretreatment of the cytosolic fraction with anti-PP2A serum attenuated the glutamate- and magnesium-mediated activation of ACC, thereby suggesting that ACC may be regulated by an OKA-sensitive PP2A-like enzyme. Magnesium 103-112 protein phosphatase 2 phosphatase activator Homo sapiens 206-210 11423479-9 2001 Streptavidin-agarose chromatography studies have indicated that glutamate- and magnesium-mediated effects on ACC are attributable to activation of ACC"s dephosphorylation; this suggests that the stimulatory effects of glutamate and magnesium on ACC might involve activation of an OKA-sensitive PP2A-like enzyme that dephosphorylates and activates ACC. Magnesium 79-88 protein phosphatase 2 phosphatase activator Homo sapiens 294-298 11431494-9 2001 In low-Mg(2+), NT-3 enhanced AMPA/kainate receptor-mediated responses elicited by inputs normally not influenced by NT-3. Magnesium 7-9 neurotrophin 3 Rattus norvegicus 15-19 11488441-4 2001 Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain. Magnesium 77-86 calmodulin 1 Rattus norvegicus 152-162 11448753-1 2001 Nitrate reductase (NR) (EC 1.6.6.1) activity and NR activation state, i.e. activity in the presence of Mg(2+) relative to activity in the absence of Mg(2+), in cucumber (Cucumis sativus) leaves increased in the light and decreased in the dark. Magnesium 103-105 nitrate reductase [NADH]-like Cucumis sativus 0-17 11448753-1 2001 Nitrate reductase (NR) (EC 1.6.6.1) activity and NR activation state, i.e. activity in the presence of Mg(2+) relative to activity in the absence of Mg(2+), in cucumber (Cucumis sativus) leaves increased in the light and decreased in the dark. Magnesium 103-105 nitrate reductase [NADH]-like Cucumis sativus 19-21 11448753-1 2001 Nitrate reductase (NR) (EC 1.6.6.1) activity and NR activation state, i.e. activity in the presence of Mg(2+) relative to activity in the absence of Mg(2+), in cucumber (Cucumis sativus) leaves increased in the light and decreased in the dark. Magnesium 103-105 nitrate reductase [NADH]-like Cucumis sativus 49-51 11412102-0 2001 Fast deuterium access to the buried magnesium/manganese site in cytochrome c oxidase. Magnesium 36-45 LOC104968582 Bos taurus 64-76 11320080-2 2001 In rabbit muscle extract PP1.I-2 is activated upon preincubation with ATP/Mg. Magnesium 74-76 inorganic pyrophosphatase 1 Homo sapiens 25-28 11320080-4 2001 We have found that PP1.I-2 in bovine brain extract is also activated upon preincubation with ATP/Mg. Magnesium 97-99 inorganic pyrophosphatase 1 Homo sapiens 19-22 11320080-9 2001 In vitro, NCLK phosphorylated I-2 on Thr(72) and activated PP1.I-2 in an ATP/Mg-dependent manner. Magnesium 77-79 inorganic pyrophosphatase 1 Homo sapiens 59-62 11462780-13 2001 There is potential interaction with insulin, in that magnesium causes hyperglycemia, which requires insulin to counteract it. Magnesium 53-62 insulin Homo sapiens 36-43 11311196-3 2001 Following the termination of 4 weeks of the combined administration of rIL-2 and recombinant interferon-alpha (rIFN-alpha), we found significant reductions of salivary flow rates at resting condition, accompanied by significant multiple compositional alterations, including increases in calcium, magnesium and phosphate concentrations, and significant reductions in total protein concentration. Magnesium 296-305 interleukin 2 Rattus norvegicus 71-76 11462780-13 2001 There is potential interaction with insulin, in that magnesium causes hyperglycemia, which requires insulin to counteract it. Magnesium 53-62 insulin Homo sapiens 100-107 11508845-7 2001 The activity of catalase in heart in the magnesium deficient group increased gradually and was significantly (P < 0.05) elevated by 27% on the 20th day of experiment whereas the superoxide dismutase activity was significantly decreased by 17% on the 20th day. Magnesium 41-50 catalase Mus musculus 16-24 11422386-4 2001 We tested several asymmetric hammerhead ribozymes targeted against the fusion site for their ability to cleave the AML1/MTG8 RNA at low magnesium concentrations. Magnesium 136-145 RUNX family transcription factor 1 L homeolog Xenopus laevis 115-119 11422386-4 2001 We tested several asymmetric hammerhead ribozymes targeted against the fusion site for their ability to cleave the AML1/MTG8 RNA at low magnesium concentrations. Magnesium 136-145 RUNX1 translocation partner 1 L homeolog Xenopus laevis 120-124 11447731-2 2001 It has been repeatedly shown that a low serum ionized magnesium (Mg2+) and a high ionized calcium to magnesium (Ca2+/Mg2+) ratio is often associated with insulin resistance, cardiovascular problems, diabetes mellitus and hypertension. Magnesium 54-63 insulin Homo sapiens 154-161 11447731-2 2001 It has been repeatedly shown that a low serum ionized magnesium (Mg2+) and a high ionized calcium to magnesium (Ca2+/Mg2+) ratio is often associated with insulin resistance, cardiovascular problems, diabetes mellitus and hypertension. Magnesium 101-110 insulin Homo sapiens 154-161 11353864-5 2001 Purified recombinant RyR3 and GST-RyR3 proteins exhibited high-affinity [(3)H]ryanodine binding that was sensitive to activation by Ca(2+) and caffeine and to inhibition by Mg(2+). Magnesium 173-175 ryanodine receptor 3 Bos taurus 21-25 11380823-0 2001 Paracellin-1 is critical for magnesium and calcium reabsorption in the human thick ascending limb of Henle. Magnesium 29-38 claudin 16 Homo sapiens 0-12 11380823-1 2001 BACKGROUND: A new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the hypomagnesemia hypercalciuria syndrome (HHS). Magnesium 168-177 claudin 16 Homo sapiens 33-45 11380823-1 2001 BACKGROUND: A new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the hypomagnesemia hypercalciuria syndrome (HHS). Magnesium 168-177 claudin 16 Homo sapiens 47-53 11380823-1 2001 BACKGROUND: A new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the hypomagnesemia hypercalciuria syndrome (HHS). Magnesium 168-177 claudin 16 Homo sapiens 223-229 11380823-12 2001 CONCLUSION: This study is the first to our knowledge to demonstrate that homozygous mutations of PCLN-1 result in a selective defect in paracellular Mg and Ca reabsorption in the TAL, with intact NaCl reabsorption ability at this site. Magnesium 149-151 claudin 16 Homo sapiens 97-103 11279208-2 2001 Here we provide the first experimental evidence for the location of Alr1p in the yeast plasma membrane and for the tight control of its expression and turnover by Mg(2+). Magnesium 163-165 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 68-73 11279208-5 2001 Mutants lacking Alr1p (Deltaalr1) showed a 60% reduction of total intracellular Mg(2+) compared with the wild type and failed to grow in standard media. Magnesium 80-82 Mg(2+) transporter ALR1 Saccharomyces cerevisiae S288C 16-21 11385565-5 2001 Even the synthesis of moderately dense, bulk MgB2 attaining 39 K superconductivity is a challenge because of the volatility and reactivity of magnesium. Magnesium 142-151 secretoglobin family 2A member 1 Homo sapiens 45-49 11385574-5 2001 Electrophysiological analysis of HEK-293 cells overexpressing recombinant LTRPC7 showed large currents regulated by millimolar levels of intracellular Mg.ATP and Mg.GTP with the permeation properties of a voltage-independent divalent cation influx pathway. Magnesium 151-153 transient receptor potential cation channel subfamily M member 7 Homo sapiens 74-80 11385574-5 2001 Electrophysiological analysis of HEK-293 cells overexpressing recombinant LTRPC7 showed large currents regulated by millimolar levels of intracellular Mg.ATP and Mg.GTP with the permeation properties of a voltage-independent divalent cation influx pathway. Magnesium 162-164 transient receptor potential cation channel subfamily M member 7 Homo sapiens 74-80 11278847-0 2001 Magnesium-dependent association and folding of oligonucleosomes reconstituted with ubiquitinated H2A. Magnesium 0-9 H2A clustered histone 18 Homo sapiens 97-100 11323343-0 2001 Modulation of NMDA receptor function by ketamine and magnesium: Part I. UNLABELLED: N-methyl-D-aspartate (NMDA) receptors are important components of pain processing. Magnesium 53-62 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 14-27 11339640-0 2001 Effect of extracellular Mg concentration on electrically induced contractions of rat vas deferens in vitro. Magnesium 24-26 arginine vasopressin Rattus norvegicus 85-88 11348887-0 2001 Oral magnesium supplementation induces favorable antiatherogenic changes in ApoE-deficient mice. Magnesium 5-14 apolipoprotein E Mus musculus 76-80 11348887-6 2001 The median plaque area was significantly smaller in magnesium-treated female apoE(-)(/)(-) mice and reached only 66% of control females (P<0.02). Magnesium 52-61 apolipoprotein E Mus musculus 77-81 11348887-11 2001 In conclusion, in apoE(-)(/)(-) mice receiving a low-fat diet, magnesium supplementation significantly inhibited atherogenesis in females but not males. Magnesium 63-72 apolipoprotein E Mus musculus 18-22 11379759-9 2001 In summary, these findings show that the exposure of MG-63 cells to cAMP analogs renders them more resistant to NO-induced damage and suggests the presence of regulatory mechanisms of the cell death pathway by cAMP in which caspase-3, -6, and -9 and cytochrome c release serves to mediate NO-induced apoptosis. Magnesium 53-55 caspase 3 Homo sapiens 224-245 11379759-9 2001 In summary, these findings show that the exposure of MG-63 cells to cAMP analogs renders them more resistant to NO-induced damage and suggests the presence of regulatory mechanisms of the cell death pathway by cAMP in which caspase-3, -6, and -9 and cytochrome c release serves to mediate NO-induced apoptosis. Magnesium 53-55 cytochrome c, somatic Homo sapiens 250-262 11302936-6 2001 Also, mFMO2-535 was significantly less stable at elevated temperatures and in the presence of cholic acid but had greater activity in the presence of magnesium. Magnesium 150-159 flavin containing monooxygenase 2 Mus musculus 6-11 11353864-5 2001 Purified recombinant RyR3 and GST-RyR3 proteins exhibited high-affinity [(3)H]ryanodine binding that was sensitive to activation by Ca(2+) and caffeine and to inhibition by Mg(2+). Magnesium 173-175 glutathione S-transferase kappa 1 Homo sapiens 30-33 11353864-5 2001 Purified recombinant RyR3 and GST-RyR3 proteins exhibited high-affinity [(3)H]ryanodine binding that was sensitive to activation by Ca(2+) and caffeine and to inhibition by Mg(2+). Magnesium 173-175 ryanodine receptor 3 Bos taurus 34-38 11282030-5 2001 The affinity of this receptor for its ligands vitronectin, fibronectin and fibrinogen can be modulated by the divalent cations magnesium, calcium and manganese. Magnesium 127-136 vitronectin Homo sapiens 46-57 11134034-8 2001 Similarly, mutation of Lys(304), which mediates the CREB interaction with the hydrated Mg(2+), blocked CREB binding to the palindromic but not the variant CRE sequences. Magnesium 87-89 cAMP responsive element binding protein 1 Homo sapiens 52-56 11134034-8 2001 Similarly, mutation of Lys(304), which mediates the CREB interaction with the hydrated Mg(2+), blocked CREB binding to the palindromic but not the variant CRE sequences. Magnesium 87-89 cAMP responsive element binding protein 1 Homo sapiens 103-107 11323344-0 2001 Modulation of NMDA receptor function by ketamine and magnesium. Magnesium 53-62 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 14-27 11282030-5 2001 The affinity of this receptor for its ligands vitronectin, fibronectin and fibrinogen can be modulated by the divalent cations magnesium, calcium and manganese. Magnesium 127-136 fibronectin 1 Homo sapiens 59-70 11282030-5 2001 The affinity of this receptor for its ligands vitronectin, fibronectin and fibrinogen can be modulated by the divalent cations magnesium, calcium and manganese. Magnesium 127-136 fibrinogen beta chain Homo sapiens 75-85 11346186-0 2001 Enhanced production of IL-1beta and IL-6 following endotoxin challenge in rats with dietary magnesium deficiency. Magnesium 92-101 interleukin 1 beta Rattus norvegicus 23-31 11346186-0 2001 Enhanced production of IL-1beta and IL-6 following endotoxin challenge in rats with dietary magnesium deficiency. Magnesium 92-101 interleukin 6 Rattus norvegicus 36-40 11346186-3 2001 ), and the increase of IL-1beta and IL-6, but not TNFalpha, was significantly larger in Mg-deficient rats than in controls. Magnesium 88-90 interleukin 6 Rattus norvegicus 36-40 11346186-4 2001 Levels of mRNA for IL-1beta, IL-6 and TNFalpha in alveolar macrophages showed a tendency to decrease during Mg deficiency, but the levels of IL-1beta and TNFalpha mRNAs after endotoxin challenge were higher in Mg-deficient rats than in controls. Magnesium 108-110 interleukin 1 beta Rattus norvegicus 19-27 11346186-4 2001 Levels of mRNA for IL-1beta, IL-6 and TNFalpha in alveolar macrophages showed a tendency to decrease during Mg deficiency, but the levels of IL-1beta and TNFalpha mRNAs after endotoxin challenge were higher in Mg-deficient rats than in controls. Magnesium 108-110 interleukin 6 Rattus norvegicus 29-33 11346186-4 2001 Levels of mRNA for IL-1beta, IL-6 and TNFalpha in alveolar macrophages showed a tendency to decrease during Mg deficiency, but the levels of IL-1beta and TNFalpha mRNAs after endotoxin challenge were higher in Mg-deficient rats than in controls. Magnesium 108-110 tumor necrosis factor Rattus norvegicus 38-46 11341499-5 2001 The effect of magnesium was relatively greater on coumarin than on normal plasma resulting in reduced prothrombin time ratio. Magnesium 14-23 coagulation factor II, thrombin Homo sapiens 102-113 11124962-8 2001 However, association of AUF1 with the ARE from tumor necrosis factor (TNFalpha) mRNA was significantly inhibited by magnesium ions. Magnesium 116-125 heterogeneous nuclear ribonucleoprotein D Homo sapiens 24-28 11341499-0 2001 Prothrombin time ratio is reduced by magnesium contamination in evacuated blood collection tubes. Magnesium 37-46 coagulation factor II, thrombin Homo sapiens 0-11 11341499-4 2001 It was shown that magnesium added to citrated plasma shortened the prothrombin time of both coumarin and normal plasma. Magnesium 18-27 coagulation factor II, thrombin Homo sapiens 67-78 11121414-8 2001 The secondary structure of NSP2 showed a high fraction of beta-sheet, with small changes induced by magnesium that were reversed in the presence of RNA. Magnesium 100-109 reticulon 2 Homo sapiens 27-31 11259758-6 2001 Spontaneous activity in isolated subiculum--CA1 slices was produced by bathing slices in reduced magnesium media. Magnesium 97-106 carbonic anhydrase 1 Rattus norvegicus 44-47 11238114-5 2001 Four distinct GPVI/FcRgamma-chain-dependent responses were found to be significantly exaggerated in platelets derived from PECAM-1-deficient mice, including Mg++-independent adhesion to immobilized fibrillar collagen, collagen-induced platelet aggregation, platelet aggregation induced by the GPVI-specific agonist collagen-related peptide, and GPVI/FcRgamma-chain-induced dense granule secretion. Magnesium 157-161 glycoprotein 6 (platelet) Mus musculus 14-18 11238114-5 2001 Four distinct GPVI/FcRgamma-chain-dependent responses were found to be significantly exaggerated in platelets derived from PECAM-1-deficient mice, including Mg++-independent adhesion to immobilized fibrillar collagen, collagen-induced platelet aggregation, platelet aggregation induced by the GPVI-specific agonist collagen-related peptide, and GPVI/FcRgamma-chain-induced dense granule secretion. Magnesium 157-161 Fc receptor, IgE, high affinity I, gamma polypeptide Mus musculus 19-27 11238114-5 2001 Four distinct GPVI/FcRgamma-chain-dependent responses were found to be significantly exaggerated in platelets derived from PECAM-1-deficient mice, including Mg++-independent adhesion to immobilized fibrillar collagen, collagen-induced platelet aggregation, platelet aggregation induced by the GPVI-specific agonist collagen-related peptide, and GPVI/FcRgamma-chain-induced dense granule secretion. Magnesium 157-161 platelet/endothelial cell adhesion molecule 1 Mus musculus 123-130 11370847-0 2001 Calcium- and magnesium-dependent interactions between the C-terminus of troponin I and the N-terminal, regulatory domain of troponin C. Magnesium 13-22 tenascin C Homo sapiens 124-134 11124962-8 2001 However, association of AUF1 with the ARE from tumor necrosis factor (TNFalpha) mRNA was significantly inhibited by magnesium ions. Magnesium 116-125 tumor necrosis factor Homo sapiens 70-78 11113147-1 2001 Vacuolar H(+)-translocating inorganic pyrophosphatase (V-PPase) uses PP(i) as an energy donor and requires free Mg(2+) for enzyme activity and stability. Magnesium 112-114 inorganic pyrophosphatase 1 Homo sapiens 57-62 11102444-3 2001 Analogous to the in vivo situation, PTH release from dispersed parathyroid cells was suppressed under low magnesium. Magnesium 106-115 parathyroid hormone Homo sapiens 36-39 11257527-1 2001 At low concentrations of phosphoenolpyruvate and magnesium, the substrate of phosphoenolpyruvate carboxylase (PEPC) from Zea mays leaves is the MgPEP complex and free phosphoenolpyruvate (fPEP) is an allosteric activator [A. Tovar-Mendez, R. Rodriguez-Sotres, D.M. Magnesium 49-58 MLO-like protein 4 Zea mays 77-108 11257527-1 2001 At low concentrations of phosphoenolpyruvate and magnesium, the substrate of phosphoenolpyruvate carboxylase (PEPC) from Zea mays leaves is the MgPEP complex and free phosphoenolpyruvate (fPEP) is an allosteric activator [A. Tovar-Mendez, R. Rodriguez-Sotres, D.M. Magnesium 49-58 MLO-like protein 4 Zea mays 110-114 11102444-5 2001 Desensitization or pertussis toxin-mediated inhibition of CaSR-stimulated signaling suppressed the effect of low magnesium, further confirming that magnesium acts within the axis CaSR-G-protein. Magnesium 113-122 calcium sensing receptor Homo sapiens 58-62 11102444-5 2001 Desensitization or pertussis toxin-mediated inhibition of CaSR-stimulated signaling suppressed the effect of low magnesium, further confirming that magnesium acts within the axis CaSR-G-protein. Magnesium 148-157 calcium sensing receptor Homo sapiens 58-62 11102444-5 2001 Desensitization or pertussis toxin-mediated inhibition of CaSR-stimulated signaling suppressed the effect of low magnesium, further confirming that magnesium acts within the axis CaSR-G-protein. Magnesium 148-157 calcium sensing receptor Homo sapiens 179-183 11102444-6 2001 However, the magnesium binding site responsible for inhibition of PTH secretion is not identical with the extracellular ion binding site of the CaSR, because the magnesium deficiency-dependent signal enhancement was not altered on CaSR receptor mutants with increased or decreased affinity for calcium and magnesium. Magnesium 13-22 parathyroid hormone Homo sapiens 66-69 11102444-7 2001 By contrast, when the magnesium affinity of the G alpha subunit was decreased, CaSR activation was no longer affected by magnesium. Magnesium 22-31 calcium sensing receptor Homo sapiens 79-83 11102444-8 2001 Thus, the paradoxical block of PTH release under magnesium deficiency seems to be mediated through a novel mechanism involving an increase in the activity of G alpha subunits of heterotrimeric G-proteins. Magnesium 49-58 parathyroid hormone Homo sapiens 31-34 11357396-4 2001 It was shown that Lon protease is an allosteric enzyme, in which the catalytic activity of peptidehydrolase sites is determined by the binding of nucleotides, their magnesium complexes, and free magnesium ions in the enzyme"s ATPase sites. Magnesium 165-174 putative ATP-dependent Lon protease Escherichia coli 18-21 11357396-4 2001 It was shown that Lon protease is an allosteric enzyme, in which the catalytic activity of peptidehydrolase sites is determined by the binding of nucleotides, their magnesium complexes, and free magnesium ions in the enzyme"s ATPase sites. Magnesium 165-174 ATPase Escherichia coli 226-232 11357396-4 2001 It was shown that Lon protease is an allosteric enzyme, in which the catalytic activity of peptidehydrolase sites is determined by the binding of nucleotides, their magnesium complexes, and free magnesium ions in the enzyme"s ATPase sites. Magnesium 195-204 putative ATP-dependent Lon protease Escherichia coli 18-21 11357396-4 2001 It was shown that Lon protease is an allosteric enzyme, in which the catalytic activity of peptidehydrolase sites is determined by the binding of nucleotides, their magnesium complexes, and free magnesium ions in the enzyme"s ATPase sites. Magnesium 195-204 ATPase Escherichia coli 226-232 11226888-6 2001 This character was very similar to that of Xenopus XRad51.1, although the binding of yeast Rad51 to DNA was more sensitive to Mg(2+) ion in both the presence and absence of ATP, and was optimal at 5--10 mM Mg(2+). Magnesium 126-128 RAD51 recombinase S homeolog Xenopus laevis 51-59 11319608-5 2001 We have found strong caspase-3-like and caspase-6-like activation upon treatment of HEK 293 cells with MG-132. Magnesium 103-105 caspase 6 Homo sapiens 40-49 11281600-8 2001 The reactivity of magnesium with seven water molecules is intermediate that of the hexa- and pentahydrate and the tetrahydrate. Magnesium 18-27 hexosaminidase subunit alpha Homo sapiens 83-87 11226888-6 2001 This character was very similar to that of Xenopus XRad51.1, although the binding of yeast Rad51 to DNA was more sensitive to Mg(2+) ion in both the presence and absence of ATP, and was optimal at 5--10 mM Mg(2+). Magnesium 126-128 recombinase RAD51 Saccharomyces cerevisiae S288C 52-57 11300617-0 2001 In vivo and in vitro effects of magnesium deficiency on hepatic haptoglobin mRNA levels. Magnesium 32-41 haptoglobin Rattus norvegicus 64-75 11300617-1 2001 We previously showed that haptoglobin (Hp) was increased in the plasma of dietary magnesium (Mg)-deficient rats. Magnesium 82-91 haptoglobin Rattus norvegicus 26-37 11300617-1 2001 We previously showed that haptoglobin (Hp) was increased in the plasma of dietary magnesium (Mg)-deficient rats. Magnesium 93-95 haptoglobin Rattus norvegicus 26-37 11226250-8 2001 Furthermore, locked open I domains, in alphaLbeta2 complexes or expressed in isolation on the cell surface, bound to intercellular adhesion molecule-1 equivalently in Mg(2+) and Mn(2+). Magnesium 167-169 intercellular adhesion molecule 1 Homo sapiens 117-150 11316255-1 2001 Magnesium-induced inhibition of the skeletal ryanodine receptor/calcium-release channel (RyR) was studied in the presence and absence of ATP under isolated conditions and in situ, by examining the RyR incorporated into a planar lipid bilayer and the calcium release flux (Rrel) in isolated single fibres mounted in the double Vaseline gap system. Magnesium 0-9 ryanodine receptor 2 Rattus norvegicus 45-87 11316255-1 2001 Magnesium-induced inhibition of the skeletal ryanodine receptor/calcium-release channel (RyR) was studied in the presence and absence of ATP under isolated conditions and in situ, by examining the RyR incorporated into a planar lipid bilayer and the calcium release flux (Rrel) in isolated single fibres mounted in the double Vaseline gap system. Magnesium 0-9 ryanodine receptor 2 Rattus norvegicus 89-92 11316255-1 2001 Magnesium-induced inhibition of the skeletal ryanodine receptor/calcium-release channel (RyR) was studied in the presence and absence of ATP under isolated conditions and in situ, by examining the RyR incorporated into a planar lipid bilayer and the calcium release flux (Rrel) in isolated single fibres mounted in the double Vaseline gap system. Magnesium 0-9 ryanodine receptor 2 Rattus norvegicus 197-200 11316255-2 2001 When the incorporated RyR had been activated by calcium (50 microM) in the absence of ATP, the magnesium-induced inhibition showed co-operativity with a Hill coefficient (N) of 1.83 and a half-inhibitory concentration (IC50) of 635 microM. Magnesium 95-104 ryanodine receptor 2 Rattus norvegicus 22-25 11277220-3 2001 The values at 30 keV became smaller by 30% for LiF:Mg, Cu, P and larger by 22% for Mg2SiO4:Tb than the ratio of the mass energy absorption coefficients of the TLDs to that of air. Magnesium 51-53 LIF interleukin 6 family cytokine Homo sapiens 47-50 11329299-12 2001 2"-Deoxyribose substitution leads to folding with reduced magnesium ion affinity in the following order: unmodified RNA > dA9 > dA10 > dC25 approximately dA10 plus dC25. Magnesium 58-67 antennal protein 10 Drosophila melanogaster 134-138 11329299-12 2001 2"-Deoxyribose substitution leads to folding with reduced magnesium ion affinity in the following order: unmodified RNA > dA9 > dA10 > dC25 approximately dA10 plus dC25. Magnesium 58-67 anon-23Cc Drosophila melanogaster 144-148 11329299-12 2001 2"-Deoxyribose substitution leads to folding with reduced magnesium ion affinity in the following order: unmodified RNA > dA9 > dA10 > dC25 approximately dA10 plus dC25. Magnesium 58-67 antennal protein 10 Drosophila melanogaster 163-167 11329299-12 2001 2"-Deoxyribose substitution leads to folding with reduced magnesium ion affinity in the following order: unmodified RNA > dA9 > dA10 > dC25 approximately dA10 plus dC25. Magnesium 58-67 anon-23Cc Drosophila melanogaster 173-177 11273006-5 2001 Magnesium treatment reduced cortical cell loss (p < 0.05), cortical alterations in microtubule-associated protein-2 (MAP-2) (p < 0.05), and both cortical and hippocampal calpain-mediated spectrin breakdown (p < 0.05 for each region) when compared to vehicle treatment. Magnesium 0-9 microtubule-associated protein 2 Rattus norvegicus 86-118 11273006-5 2001 Magnesium treatment reduced cortical cell loss (p < 0.05), cortical alterations in microtubule-associated protein-2 (MAP-2) (p < 0.05), and both cortical and hippocampal calpain-mediated spectrin breakdown (p < 0.05 for each region) when compared to vehicle treatment. Magnesium 0-9 microtubule-associated protein 2 Rattus norvegicus 120-125 11425274-3 2001 Phosphorylation of TTL is postulated to occur in its presumed Mg(++)-ATP binding fold, leading to inhibition of Mg(++)/ATP binding and TTL mediated catalysis. Magnesium 62-68 tubulin tyrosine ligase Homo sapiens 19-22 11262101-5 2001 The rotational rate and syn/anti ratio, which indicate the orientation between carbonyl oxygen and hydrogen at the 4-position, are significantly affected by addition of magnesium ion. Magnesium 169-178 synemin Homo sapiens 24-27 11425274-3 2001 Phosphorylation of TTL is postulated to occur in its presumed Mg(++)-ATP binding fold, leading to inhibition of Mg(++)/ATP binding and TTL mediated catalysis. Magnesium 62-68 tubulin tyrosine ligase Homo sapiens 135-138 11425274-3 2001 Phosphorylation of TTL is postulated to occur in its presumed Mg(++)-ATP binding fold, leading to inhibition of Mg(++)/ATP binding and TTL mediated catalysis. Magnesium 112-118 tubulin tyrosine ligase Homo sapiens 19-22 11425281-3 2001 Mg absorption requires plenty of Mg in the diet, Se, parathyroid hormone (PTH) and vitamins B6 and D. Furthermore, it is hindered by excess fat. Magnesium 0-2 parathyroid hormone Homo sapiens 53-72 11254124-0 2001 The mitochondrial inner membrane protein Lpe10p, a homologue of Mrs2p, is essential for magnesium homeostasis and group II intron splicing in yeast. Magnesium 88-97 Mfm1p Saccharomyces cerevisiae S288C 41-47 11254124-0 2001 The mitochondrial inner membrane protein Lpe10p, a homologue of Mrs2p, is essential for magnesium homeostasis and group II intron splicing in yeast. Magnesium 88-97 Mrs2p Saccharomyces cerevisiae S288C 64-69 11254124-6 2001 In the mitochondria, concentrations of magnesium, but not of several other divalent metal ions, are increased when Lpe10p is overexpressed and reduced when it is absent. Magnesium 39-48 Mfm1p Saccharomyces cerevisiae S288C 115-121 11254124-7 2001 Magnesium concentrations are raised to normal levels and growth on non-fermentable substrates is partially restored by the expression of CorA, the bacterial magnesium transporter, in the lpe10 disruptant. Magnesium 0-9 Mfm1p Saccharomyces cerevisiae S288C 187-192 11162381-1 2001 Protein tyrosine kinase Csk requires two Mg2+ ions for activity: one magnesium is part of the ATP-Mg complex, and the second free Mg2+ ion is required as an essential activator. Magnesium 69-78 C-terminal Src kinase Homo sapiens 24-27 11035011-3 2001 Using point mutants of the conserved negatively charged amino acids present in the putative pore, we have identified a single aspartate residue that determines Ca(2+) permeation of ECaC and modulation by extracellular Mg(2+). Magnesium 218-220 transient receptor potential cation channel subfamily V member 5 Oryctolagus cuniculus 181-185 11035022-3 2001 Full-length human AspRS, but not amino-terminal 32 residue-deleted, fully active AspRS, was found to bind to noncognate tRNA(fMet) in the presence of Mg(2+). Magnesium 150-152 aspartyl-tRNA synthetase 1 Homo sapiens 18-23 11314866-3 2001 In order to elucidate the effect of phospholipid composition and divalent cations (Ca(+2) and Mg(+2)) on annexin V binding to phospholipid, we used biotinylated annexin V and peroxidase-conjugated avidin D to probe the binding of annexin V to phospholipid-coated wells of polystyrene microtiter plates. Magnesium 94-96 annexin A5 Homo sapiens 105-114 11314866-9 2001 Ca(+2)-dependent binding of annexin V was competitively inhibited by Mg(+2); 5 mM Mg(+2) reduced binding significantly (p < 0.0001 by ANOVA, p < 0.05 for post hoc test of 5 mM vs 0 mM). Magnesium 69-71 annexin A5 Homo sapiens 28-37 11314866-9 2001 Ca(+2)-dependent binding of annexin V was competitively inhibited by Mg(+2); 5 mM Mg(+2) reduced binding significantly (p < 0.0001 by ANOVA, p < 0.05 for post hoc test of 5 mM vs 0 mM). Magnesium 82-84 annexin A5 Homo sapiens 28-37 11824374-7 2001 An equivalent effect of oligomycin was seen on motility to Mg++ or to vascular endothelial growth factor (VEGF) in extracellular Mg(++)-free conditions, ruling out an exclusive role for Mg++ as a migration energy producer. Magnesium 129-135 vascular endothelial growth factor A Homo sapiens 106-110 11977322-0 2001 Analysis of antioxidant enzyme activity and magnesium level in chronic obstructive pulmonary disease (COPD). Magnesium 44-53 COPD Homo sapiens 102-106 11977322-2 2001 It seems to be clinically relevant to assess prooxidant/antioxidant balance and its correlation with magnesium level in COPD. Magnesium 101-110 COPD Homo sapiens 120-124 11977322-8 2001 Patients with COPD also showed the lowered plasma magnesium level. Magnesium 50-59 COPD Homo sapiens 14-18 11977322-9 2001 The conclusion is that COPD is accompanied by a lowered magnesium level and an alteration in antioxidant status due to possible oxidative stress in this disease. Magnesium 56-65 COPD Homo sapiens 23-27 11290876-9 2001 At the end of 1-month follow-up, the Barthel ADL index was nonsignificantly higher and the Rankin disability score was marginally significantly lower in the magnesium-treated group (84 +/- 26 vs. 71.8 +/- 26, p < 0.143) than in control subjects (2.3 +/- 1.1 vs. 3 +/- 1.3, p < 0.077). Magnesium 157-166 sarcoglycan alpha Homo sapiens 45-48 11139608-3 2001 Pct1p hydrolyzes the gamma phosphate of triphosphate-terminated poly(A) in the presence of magnesium. Magnesium 91-100 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 0-5 11133266-4 2001 Further, angiotensin II may be the prime mover of the pathogenetic cascade in magnesium deficiency. Magnesium 78-87 angiotensinogen Homo sapiens 9-23 11204289-4 2001 The changes in serum potassium and magnesium were both inversely related to the insulin-mediated glucose uptake (r= -0.62, P< 0.0001; r= -0.31, P< 0.05, respectively). Magnesium 35-44 insulin Homo sapiens 80-87 11188688-10 2000 CONCLUSION: The disturbed magnesium binding site and the independence of GDP coordination from the presence of Mg2+ separate ARL2 and ARL3 from Arf proteins. Magnesium 26-35 ADP-ribosylation factor-like 2 Mus musculus 125-129 12001579-11 2001 Mg++ correlates positively with DBP (R = 0.62 in some groups). Magnesium 0-4 D-box binding PAR bZIP transcription factor Homo sapiens 32-35 12001579-17 2001 The data regarding the Ca++ and Mg++ urinary excretion and their correlation with DBP and SBP are very discordant and do not give an opportunity to make definite conclusions. Magnesium 32-36 D-box binding PAR bZIP transcription factor Homo sapiens 82-85 11188688-10 2000 CONCLUSION: The disturbed magnesium binding site and the independence of GDP coordination from the presence of Mg2+ separate ARL2 and ARL3 from Arf proteins. Magnesium 26-35 ADP-ribosylation factor-like 3 Mus musculus 134-138 11130063-3 2000 The two switch regions of Rac1 are stabilized in conformations that disrupt both magnesium binding and guanine nucleotide interaction. Magnesium 81-90 Rac family small GTPase 1 Homo sapiens 26-30 11007486-5 2000 The measurements also show that bound Mg.ADP.Pi, and not bound Mg.ATP, induces the myosin to adopt the prestroke states. Magnesium 38-40 myosin heavy chain 14 Homo sapiens 83-89 18968143-0 2000 Affinity chromatography study of magnesium and calcium binding to human serum albumin: pH and temperature variations. Magnesium 33-42 albumin Homo sapiens 72-85 18968143-1 2000 The magnesium and calcium binding on human serum albumin (HSA) was studied using an affinity chromatography approach. Magnesium 4-13 albumin Homo sapiens 43-56 11153893-0 2000 Effect of magnesium on fibrin formation from lower molecular weight (LMW) fibrinogen. Magnesium 10-19 fibrinogen beta chain Homo sapiens 74-84 10918066-3 2000 psbA mRNA (D1 protein of photosystem II), rbcL mRNA (large subunit of ribulose-1,5-bisphosphate carboxylase), 16 S rRNA, and tRNA(His) gain stability at specific magnesium concentrations in an in vitro degradation system from spinach chloroplasts. Magnesium 162-171 RuBisCO large subunit Spinacia oleracea 42-46 11060123-7 2000 Lowering intracellular magnesium by decreasing its concentration to 25 microM in the internal solution altered the time course of PSR. Magnesium 23-32 jumonji domain containing 6, arginine demethylase and lysine hydroxylase Homo sapiens 130-133 11115130-8 2000 In line with this observation, intramitochondrial magnesium concentrations are indeed restored to wild-type levels in the yeast mutant on complementation with atmrs2-1. Magnesium 50-59 magnesium transporter 2 Arabidopsis thaliana 159-167 10921926-7 2000 At physiological ionic strength the affinity of cTnC for cTnI changed very little in response to Ca(2+), although the thermodynamic data show a clear distinction between binding in the presence of Ca(2+) and in the presence of Mg(2+). Magnesium 227-229 troponin C1, slow skeletal and cardiac type Homo sapiens 48-52 10930418-7 2000 Magnesium and calcium ions present at millimolar concentrations antagonized the protective action exerted by alpha-crystallin against the thermally induced inactivation and aggregation of SDH. Magnesium 0-9 serine dehydratase Bos taurus 188-191 11009602-4 2000 Vanadate trapping of Mg.ADP caused a reversible decrease in the binding capacity of the transported substrate [(3)H]-vinblastine and the nontransported modulator [(3)H]XR9576 to P-gp in CH(r)B30 cell membranes. Magnesium 21-23 ATP binding cassette subfamily B member 1 Homo sapiens 178-182 10998347-7 2000 In addition, DeltaD3-RyR1 was more resistant to inhibition by Mg(2+). Magnesium 62-64 ryanodine receptor 1 Homo sapiens 21-25 10997940-0 2000 Topological alteration of the CYP3A4 active site by the divalent cation Mg(2+). Magnesium 72-74 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 30-36 10997940-6 2000 Based on the current results, it appears that CYP3A4 is conformationally sensitive to its in vitro environment and parameters, such as the presence of a divalent magnesium, can have a measurable effect on active site topography and consequently catalytic activity. Magnesium 162-171 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 46-52 11041546-7 2000 These results suggest that the Na+-Ca2+ exchanger (either NCX1 or NCX3) can transport Mg2+ and may play a role in the extrusion of magnesium from cells. Magnesium 131-140 solute carrier family 8 member A1 Canis lupus familiaris 58-62 11041546-7 2000 These results suggest that the Na+-Ca2+ exchanger (either NCX1 or NCX3) can transport Mg2+ and may play a role in the extrusion of magnesium from cells. Magnesium 131-140 solute carrier family 8 member A3 Rattus norvegicus 66-70 10970803-6 2000 Photoaffinity labelling with 8-azido-[alpha-(32)P]ATP confirmed that ATP binds to the ABC2 protein in the presence of Mg(2+). Magnesium 118-120 ATP binding cassette subfamily A member 2 Rattus norvegicus 86-90 10966904-8 2000 Statistically significant univariate associations were found between the CD4(+) T lymphocyte count and hematocrit, plasma magnesium concentration, and plasma zinc concentration. Magnesium 122-131 CD4 molecule Homo sapiens 73-76 10852918-5 2000 On the other hand, weak stimulation by removal of Mg(2+) block of N-methyl-d-aspartate receptors induced CaMKII signaling localized within single dendritic spines. Magnesium 50-52 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 105-111 11016794-9 2000 (c) In the Japanese sample, multiple linear regression analyses (using a stepwise procedure) showed that SBP had a significant positive association with BMI and sodium excretion, and a significant negative association with magnesium excretion, while DBP had a significant positive association with BMI and a significant negative association with the 3MH to creatinine ratio (3MH/Cre). Magnesium 223-232 selenium binding protein 1 Homo sapiens 105-108 10975407-3 2000 In a medium of Sodium, Potassium, and Magnesium [NKM] that supported active sperm motility, pHi was 6.9. Magnesium 38-47 glucose-6-phosphate isomerase Bos taurus 92-95 10825168-5 2000 We have shown directly by isothermal titration calorimetry that a group of acidic residues vital for catalytic activity in Cce1 act as ligands for the catalytic magnesium ions. Magnesium 161-170 cruciform cutting endonuclease Saccharomyces cerevisiae S288C 123-127 10846180-3 2000 We found that monoclonal antibodies against CD11a, CD11b, CD18, or LW(ab) block adhesion of transfectant L-cells to immobilized ICAM-4-Fc protein and that the ICAM-4/beta(2) integrin interaction was highly sensitive to the presence of the divalent cations Ca(2+) and Mg(2+). Magnesium 267-269 integrin subunit alpha L Homo sapiens 44-49 10846180-3 2000 We found that monoclonal antibodies against CD11a, CD11b, CD18, or LW(ab) block adhesion of transfectant L-cells to immobilized ICAM-4-Fc protein and that the ICAM-4/beta(2) integrin interaction was highly sensitive to the presence of the divalent cations Ca(2+) and Mg(2+). Magnesium 267-269 integrin subunit alpha M Homo sapiens 51-56 10846180-3 2000 We found that monoclonal antibodies against CD11a, CD11b, CD18, or LW(ab) block adhesion of transfectant L-cells to immobilized ICAM-4-Fc protein and that the ICAM-4/beta(2) integrin interaction was highly sensitive to the presence of the divalent cations Ca(2+) and Mg(2+). Magnesium 267-269 integrin subunit beta 2 Homo sapiens 58-62 10846180-3 2000 We found that monoclonal antibodies against CD11a, CD11b, CD18, or LW(ab) block adhesion of transfectant L-cells to immobilized ICAM-4-Fc protein and that the ICAM-4/beta(2) integrin interaction was highly sensitive to the presence of the divalent cations Ca(2+) and Mg(2+). Magnesium 267-269 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Homo sapiens 159-165 10983853-1 2000 When tested on Suc-Leu-Leu-Val-Tyr-MCA as substrate, purified full-length hsp90 displays a low "chymotrypsin-like" peptidase activity which is activated by Ca++ and Mg++ ions. Magnesium 165-169 heat shock protein 90 alpha family class A member 1 Homo sapiens 74-79 10973975-7 2000 Treatment with proteasomal inhibitors (MG-132, MG-115, lactacystin, or proteasome inhibitor I), but not lysosomal inhibitors, prevented degradation of LGMD-1C caveolin-3 mutants. Magnesium 39-41 caveolin 3 Homo sapiens 159-169 10973975-8 2000 In the presence of MG-132, LGMD-1C caveolin-3 mutants accumulated within the endoplasmic reticulum and did not reach the plasma membrane. Magnesium 19-21 caveolin 3 Homo sapiens 35-45 10973975-10 2000 Interestingly, in cells co-expressing wild-type and mutant forms of caveolin-3, MG-132 treatment rescued wild-type caveolin-3; wild-type caveolin-3 was not degraded and reached the plasma membrane. Magnesium 80-82 caveolin 3 Homo sapiens 68-78 10973975-10 2000 Interestingly, in cells co-expressing wild-type and mutant forms of caveolin-3, MG-132 treatment rescued wild-type caveolin-3; wild-type caveolin-3 was not degraded and reached the plasma membrane. Magnesium 80-82 caveolin 3 Homo sapiens 115-125 10973975-10 2000 Interestingly, in cells co-expressing wild-type and mutant forms of caveolin-3, MG-132 treatment rescued wild-type caveolin-3; wild-type caveolin-3 was not degraded and reached the plasma membrane. Magnesium 80-82 caveolin 3 Homo sapiens 115-125 10924156-2 2000 In cGMP-binding cGMP-specific PDE (PDE5), we showed previously that point mutation of nine of these profoundly decreases k(cat) when the assay is conducted in the presence of Mg(2+); seven of these are in the prototypical metal-binding motifs A and B (HX(3)HX(n)()E) that we identified earlier. Magnesium 175-177 phosphodiesterase 5A Homo sapiens 30-33 10825168-6 2000 Sequence similarities between the Cce1 proteins and the group I intron splicing factor Mrs1 suggest the latter may also possess a binding site for magnesium, with a putative role in stabilization of RNA tertiary structure or catalysis of the splicing reaction. Magnesium 147-156 cruciform cutting endonuclease Saccharomyces cerevisiae S288C 34-38 10924156-2 2000 In cGMP-binding cGMP-specific PDE (PDE5), we showed previously that point mutation of nine of these profoundly decreases k(cat) when the assay is conducted in the presence of Mg(2+); seven of these are in the prototypical metal-binding motifs A and B (HX(3)HX(n)()E) that we identified earlier. Magnesium 175-177 phosphodiesterase 5A Homo sapiens 35-39 10825168-6 2000 Sequence similarities between the Cce1 proteins and the group I intron splicing factor Mrs1 suggest the latter may also possess a binding site for magnesium, with a putative role in stabilization of RNA tertiary structure or catalysis of the splicing reaction. Magnesium 147-156 Mrs1p Saccharomyces cerevisiae S288C 87-91 10924156-4 2000 This report shows that mutation of either His-607 (A motif) or His-643 (B motif) to alanine profoundly diminishes support of PDE catalysis by Mn(2+) or Mg(2+), but mutation of His-647 in B motif or of Glu in either motif does not. Magnesium 152-154 phosphodiesterase 5A Homo sapiens 125-128 10915631-5 2000 For example, the human phenotype of mutations in claudin-16 suggests that it creates a channel that allows magnesium to diffuse through renal tight junctions. Magnesium 107-116 claudin 16 Homo sapiens 49-59 10900170-0 2000 Magnesium-calcium exchange in cardiac troponin C bound to cardiac troponin I. Magnesium 0-9 troponin C1, slow skeletal and cardiac type Homo sapiens 30-48 10920220-3 2000 This study showed that exposure of MG-63 osteoblast-like cells to titanium particles at a concentration of 0.30% v/v resulted in a 15-fold increase in IL-6 release into the culture medium after 24 hours, when compared with cells without particles. Magnesium 35-37 interleukin 6 Homo sapiens 151-155 10920220-4 2000 Northern blots revealed that exposure of MG-63 cells to titanium particles at a concentration of 0.30% v/v for 24 hours increased IL-6 mRNA signal levels by 9.6-fold, when compared with control cultures. Magnesium 41-43 interleukin 6 Homo sapiens 130-134 10920220-5 2000 Pretreatment of MG-63 cells with cytochalasin B prevented the particle-induced increase of IL-6 expression but did not alter the basal level of IL-6 release from cells cultured in the absence of particles. Magnesium 16-18 interleukin 6 Homo sapiens 91-95 10876221-13 2000 Moreover, MAP-2 immunoreactivity was completely lost in control rabbits, whereas it was preserved, either completely or partially, in rabbits treated with riluzole or magnesium. Magnesium 167-176 microtubule-associated protein 2 Oryctolagus cuniculus 10-15 10941109-0 2000 Halogen-Magnesium Exchange via Trialkylmagnesates for the Preparation of Aryl- and Alkenylmagnesium Reagents This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture, Japan. Magnesium 8-17 activation induced cytidine deaminase Homo sapiens 147-150 11022344-17 2000 The most prominent signs of hypomagnesemia are excitations and muscle cramps, which are closely correlated with the Mg concentration in the CSF. Magnesium 116-118 colony stimulating factor 2 Homo sapiens 140-143 10858283-5 2000 Similarly to DNase I, the nuclease activity of DNase X was dependent on Ca(2+) and Mg(2+) and inhibited by Zn(2+) ions or chelators of bivalent cations. Magnesium 83-85 deoxyribonuclease 1 like 1 Homo sapiens 47-54 10838183-5 2000 A significant increase in interleukin-6 (IL-6) plasma level was observed in Mg-deficient rats compared to rats fed a control diet. Magnesium 76-78 interleukin 6 Rattus norvegicus 26-39 10838183-5 2000 A significant increase in interleukin-6 (IL-6) plasma level was observed in Mg-deficient rats compared to rats fed a control diet. Magnesium 76-78 interleukin 6 Rattus norvegicus 41-45 10838183-7 2000 The concentrations of alpha2-macroglobulin and alpha1-acid glycoprotein in the plasma of Mg-deficient rats were higher than in control rats. Magnesium 89-91 alpha-2-macroglobulin Rattus norvegicus 22-42 10838183-11 2000 A high plasma level of IL-6 could be detected as early as day 4 for the Mg-deficient diet. Magnesium 72-74 interleukin 6 Rattus norvegicus 23-27 10747959-9 2000 TatD binds to immobilized Ni(2+) or Zn(2+) affinity columns and exhibits magnesium-dependent DNase activity. Magnesium 73-82 colicin E8 Escherichia coli 93-98 10907227-3 2000 In a previous article we presented evidence that fractional Mg2+ transport from different aqueous solutions containing differing amounts of magnesium varies considerably in some cases. Magnesium 140-149 mucin 7, secreted Homo sapiens 60-63 10838164-5 2000 PLD1 but not PLD2 activity was slightly enhanced by magnesium. Magnesium 52-61 phospholipase D1 Homo sapiens 0-4 10831861-3 2000 NMDA receptor antagonism with the combination of chlorokynurenic acid (100 microM) and elevated magnesium (1.1 mM), or elevated magnesium alone, blocked responses to NMDA without significantly altering spontaneous or stimulus-evoked discharge rate or the responses to kainate. Magnesium 96-105 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 0-13 10872900-5 2000 Mg deficient patients (47%) had lower total antioxidant capacity in plasma (p=0.007) which was related to serum albumin. Magnesium 0-2 albumin Homo sapiens 106-119 10819984-8 2000 The dissociation constants of HCV helicase for F21, HF31, and F21:HF31 in the absence of Mg(2+) were 0.6 +/- 0.4, 6 +/- 1, and 7.3 +/- 0.9 nM, respectively. Magnesium 89-91 helicase for meiosis 1 Homo sapiens 34-42 10820025-10 2000 Taken together, these data define the region of the N-terminal nucleotide-binding domain of P-glycoprotein that is required for specific ATP binding and suggest that magnesium may play a role in stabilizing the ATP-binding site. Magnesium 166-175 ATP binding cassette subfamily B member 1 Homo sapiens 92-106 10835240-10 2000 As a result, through coordinated additions of PEP, arginine, cysteine, tryptophan, and magnesium, the final concentration of cell-free synthesized CAT increased more than 4-fold compared to a batch reaction. Magnesium 87-96 chloramphenicol acetyltransferase Escherichia coli 147-150 10878399-7 2000 Serum ionized magnesium showed a significant negative correlation with plasma HbA1c and triglycerides in both microalbuminuria and clinical proteinuria groups. Magnesium 14-23 hemoglobin subunit alpha 1 Homo sapiens 78-82 10842328-3 2000 Phosphorylation of TTL is predicted to occur in a postulated Mg(++)/-ATP binding fold, leading to inhibition of Mg(++)/ATP binding and TTL mediated catalysis. Magnesium 61-67 tubulin tyrosine ligase Homo sapiens 19-22 10842328-3 2000 Phosphorylation of TTL is predicted to occur in a postulated Mg(++)/-ATP binding fold, leading to inhibition of Mg(++)/ATP binding and TTL mediated catalysis. Magnesium 61-67 tubulin tyrosine ligase Homo sapiens 135-138 10842328-3 2000 Phosphorylation of TTL is predicted to occur in a postulated Mg(++)/-ATP binding fold, leading to inhibition of Mg(++)/ATP binding and TTL mediated catalysis. Magnesium 112-118 tubulin tyrosine ligase Homo sapiens 19-22 10802529-4 2000 Besides increased Ca(2+)(o) concentration, magnesium and the polycationic antibiotic neomycin also increased PTHrP production in a concentration-dependent manner. Magnesium 43-52 parathyroid hormone-like hormone Rattus norvegicus 109-114 10799686-10 2000 Blocking inositol 1,4, 5-triphosphate receptor (IP(3)R)-dependent calcium release, with elevated extracellular Mg(2+) (20 mM), abolished calcium transient activity. Magnesium 111-113 inositol 1,4,5-trisphosphate receptor 1 Mus musculus 48-54 10859688-3 2000 High-magnesium diets have preventive (though not curative) activity in certain rodent models of diabetes; conversely, magnesium depletion provokes insulin resistance. Magnesium 118-127 insulin Homo sapiens 147-154 10819064-7 2000 MGs and clinical stages showed significant correlation; however, 55% of those in higher clinical stages (stage 3 or 4) had lower MG (MG1 or 2) and showed better prognosis than others in their group (stage 3 or 4 and MG3 or 4). Magnesium 0-3 mucin 5B, oligomeric mucus/gel-forming Homo sapiens 133-141 10819064-7 2000 MGs and clinical stages showed significant correlation; however, 55% of those in higher clinical stages (stage 3 or 4) had lower MG (MG1 or 2) and showed better prognosis than others in their group (stage 3 or 4 and MG3 or 4). Magnesium 0-2 mucin 5B, oligomeric mucus/gel-forming Homo sapiens 133-141 10756110-4 2000 Two recombinant vWF-A domains (Gly229-Ile444 and Gly229-Gln448) were examined by circular dichroism and Fourier transform infrared spectroscopy and indicated a significant conformational transition in the presence and absence of Mg(2+). Magnesium 229-231 von Willebrand factor Homo sapiens 16-19 10780900-4 2000 In the presence of magnesium, [dPen(1), 5-t-BuPro(7)]oxytocin exhibited stronger inhibitory potency than [dPen(1)]oxytocin and no partial agonism. Magnesium 19-28 oxytocin/neurophysin I prepropeptide Homo sapiens 53-61 10780900-4 2000 In the presence of magnesium, [dPen(1), 5-t-BuPro(7)]oxytocin exhibited stronger inhibitory potency than [dPen(1)]oxytocin and no partial agonism. Magnesium 19-28 oxytocin/neurophysin I prepropeptide Homo sapiens 114-122 11049196-0 2000 Priming with magnesium-deficient media inhibits preadipocyte differentiation via potential upregulation of tumor necrosis factor-alpha. Magnesium 13-22 tumor necrosis factor Sus scrofa 107-134 10753670-2 2000 Together with recent structural information on the crystal structure of self-cleaved genomic delta ribozyme, in which the L3 loop interacts with J1/4 to form the newly proposed stem P1.1, we conclude that it is likely that the P1.1 stem forms only in the presence of Mg(2+). Magnesium 267-269 exosome component 6 Homo sapiens 227-231 10753670-4 2000 When the trans-acting version of antigenomic delta ribozyme was studied, it is demonstrated that its L3 loop requires magnesium and, apparently, formation of the P1 stem for the subsequently formation of the P1.1 stem. Magnesium 118-127 exosome component 6 Homo sapiens 208-212 10767668-5 2000 Minerals such as magnesium, calcium, potassium, zinc, chromium, and vanadium appear to have associations with insulin resistance or its management. Magnesium 17-26 insulin Homo sapiens 110-117 10882535-4 2000 Immunoprecipitation with anti-Sso2p coprecipitated a approximately 100-kDa, Mg(+)-ATP-sensitive band with the 39-kDa protein, suggesting a ternary SNARE complex. Magnesium 76-81 syntaxin Saccharomyces cerevisiae S288C 30-35 10699367-0 2000 Caldesmon and heat shock protein 20 phosphorylation in nitroglycerin- and magnesium-induced relaxation of swine carotid artery. Magnesium 74-83 HSPB6 Sus scrofa 14-35 10708424-6 2000 Manganese ions were found to be essential for autophosphorylation of BGLF4, and magnesium can stimulate the activity. Magnesium 80-89 tegument serine/threonine protein kinase Human gammaherpesvirus 4 69-74 10775073-2 2000 We hypothesized that Mg depletion accounted for both the hypoparathyroidism and the renal resistance to PTH, and that Mg repletion would improve both. Magnesium 21-23 parathyroid hormone Homo sapiens 104-107 10683258-11 2000 Like wild-type IMPDH, K(+) activation of Asp50Ala is inhibited by Li(+), Na(+), Ca(2+), and Mg(2+). Magnesium 92-94 inosine-5'-monophosphate dehydrogenase 2 Cricetulus griseus 15-20 10720644-5 2000 The addition of extracellular magnesium in different concentrations (0, 0.3, 1.2, 2.4 mM) modulated the neutral sphingomyelinase-vasorelaxant action in a concentration-dependent manner. Magnesium 30-39 sphingomyelin phosphodiesterase 2 Rattus norvegicus 104-128 10838731-0 2000 Correlation of serum and CSF magnesium levels of normal newborns with maternal serum magnesium. Magnesium 29-38 colony stimulating factor 2 Homo sapiens 25-28 10817660-8 2000 Taking into consideration these results with our previous reports, it is suggested that cadmium binds to the calcium-binding sites of calmodulin and activates calcium/calmodulin-dependent enzymes in a disorderly manner, whereas magnesium does not. Magnesium 228-237 calmodulin 1 Rattus norvegicus 134-144 10692332-1 2000 In an effort to test the lever arm model of force generation, the effects of replacing magnesium with calcium as the ATP-chelated divalent cation were determined for several myosin and actomyosin reactions. Magnesium 87-96 myosin heavy chain 14 Homo sapiens 174-180 10694260-9 2000 Simulations using a sequential model for activation reproduced the key features of eag ionic and gating currents and their modulation by prepulse hyperpolarization and extracellular Mg(2+). Magnesium 182-184 ether a go-go Drosophila melanogaster 83-86 10838731-0 2000 Correlation of serum and CSF magnesium levels of normal newborns with maternal serum magnesium. Magnesium 85-94 colony stimulating factor 2 Homo sapiens 25-28 10726923-0 2000 Insulin-mediated glucose disposal is decreased in normal subjects with relatively low plasma magnesium concentrations. Magnesium 93-102 insulin Homo sapiens 0-7 10726923-1 2000 The relationship between the plasma magnesium (Mg) concentration and steady-state plasma insulin (SSPI) and glucose (SSPG) concentrations at the end of a 180-minute infusion of octreotide, insulin, and glucose was determined in 98 healthy nondiabetic subjects. Magnesium 36-45 insulin Homo sapiens 89-96 10726923-6 2000 These results indicate that variations in the plasma Mg concentration have a relatively modest but significant effect on insulin-mediated glucose disposal in healthy subjects, with lower plasma Mg concentrations associated with increased insulin resistance. Magnesium 53-55 insulin Homo sapiens 121-128 10726923-6 2000 These results indicate that variations in the plasma Mg concentration have a relatively modest but significant effect on insulin-mediated glucose disposal in healthy subjects, with lower plasma Mg concentrations associated with increased insulin resistance. Magnesium 194-196 insulin Homo sapiens 238-245 10681556-2 2000 In this study, we report the biochemical and functional characterization and subcellular localization of magnesium-dependent nSMase1 from overexpressing human embryonic kidney (HEK293) cells. Magnesium 105-114 sphingomyelin phosphodiesterase 2 Homo sapiens 125-132 10684600-0 2000 Mutagenesis of E477 or K505 in the B" domain of human topoisomerase II beta increases the requirement for magnesium ions during strand passage. Magnesium 106-115 DNA topoisomerase II beta Homo sapiens 54-75 11049208-0 2000 Atrial natriuretic peptide and thyroid hormones" relation to plasma and heart calcium and magnesium concentrations of Wistar rats exposed to cold and hot ambients. Magnesium 90-99 natriuretic peptide A Rattus norvegicus 0-26 11049208-6 2000 Results also indicate that plasma ANP and T3 levels are proportionally related, whereas an inverse relationship exists between plasma ANP and T3 levels and heart Mg concentrations, in both cold and hot exposed rats. Magnesium 162-164 natriuretic peptide A Rattus norvegicus 134-137 11049208-7 2000 In conclusion, ANP and thyroid hormones in relation to Ca and Mg play an important role in temperature adaptation. Magnesium 62-64 natriuretic peptide A Rattus norvegicus 15-18 10821430-6 2000 Small DS proteoglycans, decorin and biglycan, were detected in fibroblasts and MG-63 cultures. Magnesium 79-81 biglycan Homo sapiens 36-44 10701516-6 2000 The production process allows an LiF:Mg,Cu,P load of up to 50%. Magnesium 37-39 LIF interleukin 6 family cytokine Homo sapiens 33-36 10663389-10 2000 In the middle zone of immature joint cartilage, corresponding to the predilective site of quinolone-induced cartilage lesions, we observed a slight increase in staining with the fibronectin antibody in some samples from magnesium-deficient dogs. Magnesium 220-229 fibronectin 1 Canis lupus familiaris 178-189 10663389-13 2000 However, magnesium deficiency in immature dogs induced similar clinical symptoms as quinolone treatment as well as distinct alterations in chondrocytic fibronectin staining and their ultrastructure. Magnesium 9-18 fibronectin 1 Canis lupus familiaris 152-163 10674850-4 2000 The serum phosphorus and magnesium concentrations decreased to nadirs of 1.6 mg/dl and 1.6 mg/dl respectively 7 hours after insulin injection. Magnesium 25-34 insulin Homo sapiens 124-131 10601323-6 1999 These results indicate that NBF1 of SUR1 binds 8-azido-ATP strongly in a magnesium-independent manner and that NBF2 binds 8-azido-ATP weakly in a magnesium-dependent manner. Magnesium 73-82 ATP binding cassette subfamily C member 8 Homo sapiens 36-40 10601323-6 1999 These results indicate that NBF1 of SUR1 binds 8-azido-ATP strongly in a magnesium-independent manner and that NBF2 binds 8-azido-ATP weakly in a magnesium-dependent manner. Magnesium 146-155 ATP binding cassette subfamily C member 8 Homo sapiens 36-40 10656801-4 2000 We have solved the crystal structure of Hal2p in complex with magnesium, lithium and the two products of PAP hydrolysis, AMP and Pi, at 1.6 A resolution. Magnesium 62-71 3'(2'),5'-bisphosphate nucleotidase Saccharomyces cerevisiae S288C 40-45 11272530-3 2000 The magnesium compound [Mg4(mu3,eta2-ddbfo)2(mu,eta2-ddbfo)2(mu,eta1-ddbfo)2(eta1-ddbfo)2] x 2CH2Cl2 (1) (ddbfo = 2,3-dihydro-2,2-dimethyl-7-benzofuranoxide) was prepared by the reaction of MgBu2 with ddbfoH in dichloromethane. Magnesium 4-13 DNA polymerase iota Homo sapiens 32-36 11272530-3 2000 The magnesium compound [Mg4(mu3,eta2-ddbfo)2(mu,eta2-ddbfo)2(mu,eta1-ddbfo)2(eta1-ddbfo)2] x 2CH2Cl2 (1) (ddbfo = 2,3-dihydro-2,2-dimethyl-7-benzofuranoxide) was prepared by the reaction of MgBu2 with ddbfoH in dichloromethane. Magnesium 4-13 DNA polymerase iota Homo sapiens 48-52 11272530-3 2000 The magnesium compound [Mg4(mu3,eta2-ddbfo)2(mu,eta2-ddbfo)2(mu,eta1-ddbfo)2(eta1-ddbfo)2] x 2CH2Cl2 (1) (ddbfo = 2,3-dihydro-2,2-dimethyl-7-benzofuranoxide) was prepared by the reaction of MgBu2 with ddbfoH in dichloromethane. Magnesium 4-13 secreted phosphoprotein 1 Homo sapiens 64-68 11272530-3 2000 The magnesium compound [Mg4(mu3,eta2-ddbfo)2(mu,eta2-ddbfo)2(mu,eta1-ddbfo)2(eta1-ddbfo)2] x 2CH2Cl2 (1) (ddbfo = 2,3-dihydro-2,2-dimethyl-7-benzofuranoxide) was prepared by the reaction of MgBu2 with ddbfoH in dichloromethane. Magnesium 4-13 secreted phosphoprotein 1 Homo sapiens 77-81 10636912-0 2000 Mutation in the magnesium binding site of hMSH6 disables the hMutSalpha sliding clamp from translocating along DNA. Magnesium 16-25 mutS homolog 6 Homo sapiens 42-47 10634373-9 2000 In the Vit.E group, the percent change in brachial artery diameter correlated positively with the percent change in oxidative stress indexes (oxidized/reduced glutathione, Trolox-equivalent antioxidant capacity, thiobarbituric acid reaction products, lipid peroxides) and intracellular cation content (magnesium and calcium). Magnesium 302-311 vitrin Homo sapiens 7-10 11092238-6 2000 Divalent ions (calcium and magnesium ions) added to 10 mM of Tris buffer significantly inactivated HBD-2 at much lower concentrations (more than or equal to 0.01 mM and 0.05 mM, respectively) than the monovalent ions did. Magnesium 27-36 defensin beta 4A Homo sapiens 99-104 10717429-1 2000 Neuropeptide Y reduced spontaneous and stimulation-evoked epileptiform discharges in rat frontal cortex slices perfused with a magnesium-free solution and with the GABA(A) receptor antagonist picrotoxin. Magnesium 127-136 neuropeptide Y Rattus norvegicus 0-14 10601245-6 1999 We observed that disruption of raft integrity by lowering the membrane cholesterol content abolished the CTx and the phorbol 12-myristate 13-acetate-induced LFA-1 binding but left the ability to activate LFA-1 with Mg(2+)/EGTA unimpaired. Magnesium 215-218 integrin alpha L Mus musculus 204-209 10588894-0 1999 Magnesium ions enhance the transfer of human papillomavirus E2 protein from non-specific to specific binding sites. Magnesium 0-9 ubiquitin conjugating enzyme E2 B Homo sapiens 60-70 10883305-8 1999 Phosphorous and magnesium had small variations: P (229, 243 and 212) and Mg (28, 23 and 23) for L1, L2 and L3. Magnesium 16-25 60S ribosomal protein L8 Solanum lycopersicum 100-109 10600123-12 1999 The striking effect of magnesium ions on the affinity of Cce1 binding to the four-way junction is predicted to be a general one for proteins that unfold the stacked X-structure of the Holliday junction on binding. Magnesium 23-32 cruciform cutting endonuclease Saccharomyces cerevisiae S288C 57-61 10585740-5 1999 Six factors influenced CYP1A2-mediated MROD rates: buffer type, pH, temperature, Mg/EDTA, NADH, and glycerol. Magnesium 81-83 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 23-29 10585740-7 1999 Secondly, the combined effects of ionic strength and Mg concentration on NIF/CYP3A4 were studied and easily modeled using another statistic experimental design. Magnesium 53-55 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 77-83 10567242-8 1999 Molecular modelling of PfSAMS guided by the X-ray crystal structure of E. coli SAMS indicates that PfSAMS binds ATP/Mg(2+) in a manner similar to that seen in the E. coli SAMS structure. Magnesium 116-118 methionine adenosyltransferase 1A Homo sapiens 25-29 10567242-8 1999 Molecular modelling of PfSAMS guided by the X-ray crystal structure of E. coli SAMS indicates that PfSAMS binds ATP/Mg(2+) in a manner similar to that seen in the E. coli SAMS structure. Magnesium 116-118 methionine adenosyltransferase 1A Homo sapiens 79-83 10578053-10 1999 In addition, p84 phosphorylation was prevented by the presence of divalent cations such as Mg(2+) and Mn(2+). Magnesium 91-93 THO complex 1 Homo sapiens 13-16 10565849-3 1999 On the other hand, NPY (10 microM)-stimulated high-affinity GTPase activity was detectable even in the absence of Mg(2+). Magnesium 114-116 neuropeptide Y Rattus norvegicus 19-22 10633465-4 1999 The CaR also affects the renal handling of sodium, magnesium and water. Magnesium 51-60 calcium sensing receptor Homo sapiens 4-7 10555980-7 1999 Additionally, the novel observation was made of magnesium-dependent, fluoride-mediated binding of Ras.GDP to NF1 in the absence of aluminum. Magnesium 48-57 neurofibromin 1 Homo sapiens 109-112 10612083-9 1999 Serum PTH concentration fell progressively in the Mg deficient rats to 30 pg/ml by week 16 (control = 96 pg/ml). Magnesium 50-52 parathyroid hormone Rattus norvegicus 6-9 10612086-6 1999 Pearson"s correlation analysis, separately performed in each group of subjects, showed that plasma aldosterone, renin, epinephrine, norepinephrine and magnesium fractional excretion were negatively correlated to platelet magnesium levels in NT-Ob and HT-Ob groups, but not in lean controls. Magnesium 221-230 renin Homo sapiens 112-117 10612086-9 1999 The impairment in platelet magnesium handling observed in normotensive and hypertensive obese patients seems to be associated to a rise in renin-angiotensin-aldosterone and sympathetic systems activity. Magnesium 27-36 renin Homo sapiens 139-144 10612087-0 1999 Correlation of serum HDL-cholesterol and LCAT levels with the fraction of ionized magnesium in children. Magnesium 82-91 lecithin-cholesterol acyltransferase Homo sapiens 41-45 10612087-4 1999 However, the fraction of ionized magnesium was significantly correlated with HDL-cholesterol (n = 46, r = 0.31, p = 0.0345), apolipoprotein A-1 (n = 41, r = 0.39, p = 0.0124), and lecithin-cholesterol acyltransferase (LCAT) (n = 20, r = 52, p = 0.0184). Magnesium 33-42 apolipoprotein A1 Homo sapiens 125-143 10612087-4 1999 However, the fraction of ionized magnesium was significantly correlated with HDL-cholesterol (n = 46, r = 0.31, p = 0.0345), apolipoprotein A-1 (n = 41, r = 0.39, p = 0.0124), and lecithin-cholesterol acyltransferase (LCAT) (n = 20, r = 52, p = 0.0184). Magnesium 33-42 lecithin-cholesterol acyltransferase Homo sapiens 180-216 10612087-4 1999 However, the fraction of ionized magnesium was significantly correlated with HDL-cholesterol (n = 46, r = 0.31, p = 0.0345), apolipoprotein A-1 (n = 41, r = 0.39, p = 0.0124), and lecithin-cholesterol acyltransferase (LCAT) (n = 20, r = 52, p = 0.0184). Magnesium 33-42 lecithin-cholesterol acyltransferase Homo sapiens 218-222 10612087-5 1999 These results suggest that fraction of ionized magnesium is more closely linked to serum HDL-cholesterol and LCAT level than with the serum total magnesium level or whole blood ionized magnesium. Magnesium 47-56 lecithin-cholesterol acyltransferase Homo sapiens 109-113 10600123-1 1999 Cce1 is a magnesium-dependent Holliday junction endonuclease involved in the resolution of recombining mitochondrial DNA in Saccharomyces cerevisiae. Magnesium 10-19 cruciform cutting endonuclease Saccharomyces cerevisiae S288C 0-4 10600123-3 1999 In the present study, we have examined the interactions of wild-type Cce1 with a noncleavable four-way DNA junction and metal ions (Mg(2+) and Mn(2+)) using isothermal titration calorimetry, EPR, and gel electrophoresis techniques. Magnesium 132-134 cruciform cutting endonuclease Saccharomyces cerevisiae S288C 69-73 10600123-5 1999 Cce1 binds to four-way junctions with a stoichiometry of two Cce1 dimers per junction molecule in the presence of EDTA, and one dimer of Cce1 per junction in 15 mM magnesium. Magnesium 164-173 cruciform cutting endonuclease Saccharomyces cerevisiae S288C 0-4 10659375-2 1999 In this study combined infusion therapy with procain, pentoxyphyllin and magnesium sulphuricum in patients with CTS was evaluated retrospectively. Magnesium 73-82 transthyretin Homo sapiens 112-115 10726809-7 1999 No special fraction clearly indicates magnesium deficiency leading to insulin resistance. Magnesium 38-47 insulin Homo sapiens 70-77 10559438-5 1999 Transgenic tobacco plants expressing CAX1 displayed symptoms of Ca(2+) deficiencies, including hypersensitivity to ion imbalances, such as increased magnesium and potassium concentrations, and to cold shock, but increasing the Ca(2+) in the media abrogated these sensitivities. Magnesium 149-158 cation exchanger 1 Arabidopsis thaliana 37-41 10506531-0 1999 Postinjury magnesium treatment attenuates traumatic brain injury-induced cortical induction of p53 mRNA in rats. Magnesium 11-20 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 95-98 10506531-2 1999 The present study examined the effect of magnesium on posttraumatic regional induction of p53, a gene associated with induction of cell death. Magnesium 41-50 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 90-93 10523391-2 1999 We therefore created an in vitro model of red blood cell ischemia to investigate whether the protective effects of these compounds might be related to effects on intracellular free Mg (Mg(i)) content. Magnesium 181-183 CMS1A1 Homo sapiens 185-190 10562337-0 1999 Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells. Magnesium 26-35 carbonic anhydrase 1 Rattus norvegicus 73-76 10512641-0 1999 Battle for the EF-hands: magnesium-calcium interference in calmodulin. Magnesium 25-34 calmodulin 1 Homo sapiens 59-69 10583708-17 1999 The indication from the good correlation between bone-Mg and %Ret and a marked decrease in %Ret in patients after Mg medication was that one can really measure magnesium deficiency. Magnesium 160-169 ret proto-oncogene Homo sapiens 62-65 10583708-17 1999 The indication from the good correlation between bone-Mg and %Ret and a marked decrease in %Ret in patients after Mg medication was that one can really measure magnesium deficiency. Magnesium 160-169 ret proto-oncogene Homo sapiens 92-95 10548063-0 1999 Cooperative effects of potassium, magnesium, and magnesium-ADP on the release of Escherichia coli dihydrofolate reductase from the chaperonin GroEL. Magnesium 34-43 chaperonin GroEL Escherichia coli 131-147 10548063-2 1999 In this paper, we investigate the effects of potassium, magnesium, and MgADP on the release of the EcDHFR late folding intermediate from GroEL. Magnesium 56-65 dihydrofolate reductase Escherichia coli 99-105 10548063-2 1999 In this paper, we investigate the effects of potassium, magnesium, and MgADP on the release of the EcDHFR late folding intermediate from GroEL. Magnesium 56-65 GroEL Escherichia coli 137-142 10548063-4 1999 In the absence of potassium, magnesium, and ADP, approximately 80-90% of GroEL resides in the form with the faster rate of release. Magnesium 29-38 GroEL Escherichia coli 73-78 10548063-5 1999 Magnesium and potassium both shift the distribution of GroEL forms toward the form with the slower release rate, though cooperativity for the magnesium-induced transition is observed only in the presence of potassium. Magnesium 0-9 GroEL Escherichia coli 55-60 10548063-5 1999 Magnesium and potassium both shift the distribution of GroEL forms toward the form with the slower release rate, though cooperativity for the magnesium-induced transition is observed only in the presence of potassium. Magnesium 142-151 GroEL Escherichia coli 55-60 10548063-8 1999 In the presence of saturating magnesium, potassium, and MgADP, the apparent rate constant for the release of EcDHFR from wild-type GroEL at 22 degrees C reaches a limiting value of 0.014 s(-1). Magnesium 30-39 dihydrofolate reductase Escherichia coli 109-115 10548063-8 1999 In the presence of saturating magnesium, potassium, and MgADP, the apparent rate constant for the release of EcDHFR from wild-type GroEL at 22 degrees C reaches a limiting value of 0.014 s(-1). Magnesium 30-39 GroEL Escherichia coli 131-136 10526129-11 1999 Ajacine and lappaconitine inhibited stimulus-triggered epileptiform population bursts in area CA1 elicited by omission of Mg(2+) as well as spontaneously occurring epileptiform discharges in area CA3 elicited by omission of Mg(2+) and elevation of K(+). Magnesium 122-124 carbonic anhydrase 1 Rattus norvegicus 94-97 10512641-1 1999 The ubiquitous Ca(2+)-regulatory protein calmodulin activates target enzymes as a response to submicromolar Ca(2+) increases in a background of millimolar Mg(2+). Magnesium 155-157 calmodulin 1 Homo sapiens 41-51 10471799-1 1999 In the present work, we studied the interactions of recombinant alpha1 and alpha2 integrin I domains with cations Tb(3+), Mn(2+), Mg(2+) and Ca(2+). Magnesium 130-132 adrenoceptor alpha 1D Homo sapiens 64-70 10619500-7 1999 This study suggests that some patients with MG may benefit from a treatment combining radiotherapy to symptomatic areas and chemotherapy with agents that cross the blood-brain barrier or are delivered directly into the CSF. Magnesium 44-46 colony stimulating factor 2 Homo sapiens 219-222 10488472-0 1999 The influence of ethanol and magnesium on aminoacyl-tRNA synthetases activity in rat"s liver. Magnesium 29-38 alanyl-tRNA synthetase 1 Rattus norvegicus 42-68 10488472-2 1999 Experiments were conducted in order to determine the influence of ethanol and magnesium on the aminoacyl-tRNA synthetases (aaRS) activity in rat"s liver. Magnesium 78-87 alanyl-tRNA synthetase 1 Rattus norvegicus 95-121 10488472-2 1999 Experiments were conducted in order to determine the influence of ethanol and magnesium on the aminoacyl-tRNA synthetases (aaRS) activity in rat"s liver. Magnesium 78-87 alanyl-tRNA synthetase 1 Rattus norvegicus 123-127 10488473-1 1999 It has been postulated that parathormone, calcitonine, insulin and catecholamines are involved in extracellular magnesium homeostasis. Magnesium 112-121 insulin Homo sapiens 55-62 10488476-7 1999 Increased levels of harmful neurochemical mediators that have been reported in these conditions include oxygen free radicals, excitatory amino acids, tumor necrosis factor-alpha (TNF-a), and thromboxane A2 (TXA2) which are aggravated in magnesium deficiency and may be ameliorated by magnesium. Magnesium 237-246 tumor necrosis factor Homo sapiens 150-177 11379859-0 1999 Serum magnesium concentration is an independent predictor of parathyroid hormone levels in peritoneal dialysis patients. Magnesium 6-15 parathyroid hormone Homo sapiens 61-80 11379859-5 1999 However, magnesium may also be able to modulate PTH secretion in a way similar to calcium. Magnesium 9-18 parathyroid hormone Homo sapiens 48-51 11379859-15 1999 There was a significant correlation between serum Mg and PTH levels (r= -0.70, p< 0.01). Magnesium 50-52 parathyroid hormone Homo sapiens 57-60 11379859-16 1999 After controlling for the effect of other variables by partial correlation analysis, a significant positive association between P and PTH (r= 0.25, p < 0.05), and a negative relationship between Mg and PTH (r= -0.57, p < 0.001) were evident. Magnesium 198-200 parathyroid hormone Homo sapiens 205-208 10420165-3 1999 In contrast, the amplitude of NMDAr-mediated fEPSPs isolated in a magnesium-free medium after blockade of non-NMDAr and GABAergic receptors was significantly depressed in these animals. Magnesium 66-75 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 30-35 10420165-3 1999 In contrast, the amplitude of NMDAr-mediated fEPSPs isolated in a magnesium-free medium after blockade of non-NMDAr and GABAergic receptors was significantly depressed in these animals. Magnesium 66-75 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 110-115 10434065-9 1999 When assayed with benzoic acid as substrate, both HXM-A and HXM-B had an absolute dependence on either Mg(2+) or Mn(2+) for activity. Magnesium 103-105 acyl-CoA synthetase medium chain family member 2B Homo sapiens 50-65 10480466-0 1999 Low dietary magnesium is associated with insulin resistance in a sample of young, nondiabetic Black Americans. Magnesium 12-21 insulin Homo sapiens 41-48 10480466-1 1999 In both humans and experimental animals, dietary induced magnesium deficiency is correlated with insulin resistance. Magnesium 57-66 insulin Homo sapiens 97-104 10480466-2 1999 The purpose of this study was to determine whether dietary magnesium intake is associated with insulin sensitivity or blood pressure in a sample of nondiabetic, young adult black Americans. Magnesium 59-68 insulin Homo sapiens 95-102 10480466-9 1999 There was a significant negative correlation of total dietary magnesium intake with the sum of insulin levels measured during an oral glucose tolerance test (OGTT) (r = -0.13, P < .05). Magnesium 62-71 insulin Homo sapiens 95-102 10480466-10 1999 When corrected for body fat, in men there was also a significant correlation of dietary magnesium intake, measured in mg/kg of fat-free mass, with the sum of insulin concentrations on the OGTT (r = -0.22, P < .05). Magnesium 88-97 insulin Homo sapiens 158-165 10480466-12 1999 These results suggest a possible role for dietary magnesium in insulin resistance. Magnesium 50-59 insulin Homo sapiens 63-70 10454768-1 1999 High magnesium concentration inhibits the effect of arginine vasopressin (AVP) on smooth muscle contraction and platelet aggregation and also influences hepatocyte AVP receptor binding. Magnesium 5-14 vasopressin-neurophysin 2-copeptin Oryctolagus cuniculus 52-78 10454768-1 1999 High magnesium concentration inhibits the effect of arginine vasopressin (AVP) on smooth muscle contraction and platelet aggregation and also influences hepatocyte AVP receptor binding. Magnesium 5-14 vasopressin-neurophysin 2-copeptin Oryctolagus cuniculus 74-77 10454768-2 1999 The aim of this study was to determine the role of magnesium concentration [Mg2+] in AVP-stimulated water transport in the kidney collecting duct. Magnesium 51-60 vasopressin-neurophysin 2-copeptin Oryctolagus cuniculus 85-88 10454768-9 1999 These data indicate that magnesium may play a modulatory role in the action of AVP on CCD osmotic water permeability, as observed in other tissues. Magnesium 25-34 vasopressin-neurophysin 2-copeptin Oryctolagus cuniculus 79-82 10469152-9 1999 The ALP is magnesium-dependent for its catalytic activity and was inhibited after incubation of ALP-containing liposomes in a magnesium-free buffer. Magnesium 11-20 alkaline phosphatase, placental Homo sapiens 4-7 10469152-9 1999 The ALP is magnesium-dependent for its catalytic activity and was inhibited after incubation of ALP-containing liposomes in a magnesium-free buffer. Magnesium 11-20 alkaline phosphatase, placental Homo sapiens 96-99 10430554-4 1999 From a mechanistic viewpoint, Mg deprivation may influence cell cycle control by upregulating the cyclin inhibitor p27Kip1 thus influencing cyclin E-dependent kinases. Magnesium 30-32 proliferating cell nuclear antigen Homo sapiens 98-104 10430554-4 1999 From a mechanistic viewpoint, Mg deprivation may influence cell cycle control by upregulating the cyclin inhibitor p27Kip1 thus influencing cyclin E-dependent kinases. Magnesium 30-32 cyclin dependent kinase inhibitor 1B Homo sapiens 115-122 10430554-4 1999 From a mechanistic viewpoint, Mg deprivation may influence cell cycle control by upregulating the cyclin inhibitor p27Kip1 thus influencing cyclin E-dependent kinases. Magnesium 30-32 proliferating cell nuclear antigen Homo sapiens 140-146 10430554-8 1999 When differentiation process is induced by receptor mediated stimuli such as IFN-alpha and ATP, decrease of cell Mg content accompanies with activation of Mg efflux. Magnesium 113-115 interferon alpha 1 Homo sapiens 77-86 10430554-8 1999 When differentiation process is induced by receptor mediated stimuli such as IFN-alpha and ATP, decrease of cell Mg content accompanies with activation of Mg efflux. Magnesium 155-157 interferon alpha 1 Homo sapiens 77-86 10457223-9 1999 Cell adhesion was dependent on extracellular divalent cations, a characteristic event of VLA-1 never before shown for IELs: manganese and magnesium ions supported binding in a dose-dependent manner; calcium ions inhibited their effectiveness. Magnesium 138-147 integrin subunit alpha 1 Homo sapiens 89-94 10395294-0 1999 Magnesium depletion causes growth inhibition, reduced expression of cyclin D1, and increased expression of P27Kip1 in normal but not in transformed mammary epithelial cells. Magnesium 0-9 cyclin D1 Homo sapiens 68-77 10395294-0 1999 Magnesium depletion causes growth inhibition, reduced expression of cyclin D1, and increased expression of P27Kip1 in normal but not in transformed mammary epithelial cells. Magnesium 0-9 cyclin dependent kinase inhibitor 1B Homo sapiens 107-114 10395294-6 1999 Extracellular magnesium depletion was associated with increased expression of the cyclin-dependent kinase inhibitor p27Kip1 and decreased expression of cyclin D1 in the HC11 but not in the MCF-7 cells. Magnesium 14-23 cyclin dependent kinase inhibitor 1B Homo sapiens 116-123 10395294-6 1999 Extracellular magnesium depletion was associated with increased expression of the cyclin-dependent kinase inhibitor p27Kip1 and decreased expression of cyclin D1 in the HC11 but not in the MCF-7 cells. Magnesium 14-23 cyclin D1 Homo sapiens 152-161 10395294-6 1999 Extracellular magnesium depletion was associated with increased expression of the cyclin-dependent kinase inhibitor p27Kip1 and decreased expression of cyclin D1 in the HC11 but not in the MCF-7 cells. Magnesium 14-23 C-C motif chemokine ligand 2 Homo sapiens 169-173 10400670-7 1999 Disruption of the MRS2 gene leads to a significant decrease in total magnesium content of mitochondria which is compensated for by the overexpression of the CorA gene. Magnesium 69-78 Mrs2p Saccharomyces cerevisiae S288C 18-22 10498191-0 1999 Structure-related enhancing activity of escins Ia, Ib, IIa and IIb on magnesium absorption in mice. Magnesium 70-79 ATPase, class II, type 9A Mus musculus 55-58 10498191-0 1999 Structure-related enhancing activity of escins Ia, Ib, IIa and IIb on magnesium absorption in mice. Magnesium 70-79 ATPase, class II, type 9B Mus musculus 63-66 10621945-26 1999 Combined trace element supplementation with Se, Mn, or Mg, which prevails over the expression of detoxifying enzymes or counteracts intracellular elevations of Ca2+, may reduce the neurotoxic impact of A beta s. 9. Magnesium 55-57 amyloid beta precursor protein Homo sapiens 202-208 10400613-9 1999 Furthermore, we show that CD39-L4 is an E-type apyrase, is dependent on calcium and magnesium cations, and has high degree of specificity for NDPs over NTPs as enzymatic substrates. Magnesium 84-93 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 26-30 10406802-5 1999 We report here the cloning and characterization of an Arabidopsis thaliana transporter, designated AtMHX, which is localized in the vacuolar membrane and functions as an electrogenic exchanger of protons with Mg(2+) and Zn(2+) ions. Magnesium 209-211 magnesium/proton exchanger Arabidopsis thaliana 99-104 10469152-9 1999 The ALP is magnesium-dependent for its catalytic activity and was inhibited after incubation of ALP-containing liposomes in a magnesium-free buffer. Magnesium 126-135 alkaline phosphatase, placental Homo sapiens 4-7 10469152-9 1999 The ALP is magnesium-dependent for its catalytic activity and was inhibited after incubation of ALP-containing liposomes in a magnesium-free buffer. Magnesium 126-135 alkaline phosphatase, placental Homo sapiens 96-99 10469152-10 1999 The ALP activity was restored by the addition of detergent to the liposomes, due to the release of the luminal magnesium ions. Magnesium 111-120 alkaline phosphatase, placental Homo sapiens 4-7 10431997-10 1999 The peak serum levels of interleukin-6 (IL-6) were significantly lower in the magnesium group than those in the placebo group (38.9 +/- 25.0 vs 92.3 +/- 76.5 pg/mL, p = 0.016). Magnesium 78-87 interleukin 6 Homo sapiens 25-38 10391955-6 1999 However, unlike ARF1, release of membrane-bound ARF6 to the cytosol requires hydrolysis of GTP that is sensitive to the level of magnesium. Magnesium 129-138 ADP ribosylation factor 6 Homo sapiens 48-52 10391955-8 1999 Moreover, as ARF6 has little intrinsic ability to hydrolyze GTP, magnesium concentration most likely affects the release of membrane-bound ARF6 by altering the activity of its GTPase-activating protein. Magnesium 65-74 ADP ribosylation factor 6 Homo sapiens 139-143 10390358-3 1999 Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Magnesium 6-15 transaldolase 1 Homo sapiens 132-135 10401014-1 1999 Acute magnesium (Mg) infusion decreases patathyroid hormone (PTH) secretion. Magnesium 6-15 parathyroid hormone Homo sapiens 61-64 10401014-1 1999 Acute magnesium (Mg) infusion decreases patathyroid hormone (PTH) secretion. Magnesium 17-19 parathyroid hormone Homo sapiens 61-64 10401014-8 1999 Mg and Ca were inversely correlated with PTH levels (r = -0.48; P < 0.001 and r = -0.21; P < 0.05, respectively). Magnesium 0-2 parathyroid hormone Homo sapiens 41-44 10401014-11 1999 Patients with inadequately low PTH levels (relative hypoparathyroidism, PTH < 120 pg/mL; n = 52) showed greater serum Mg concentrations than the rest (n = 58; 3.01 +/- 0.33 v 2.63 +/- 0.38 mg/dL; P < 0.001). Magnesium 121-123 parathyroid hormone Homo sapiens 31-34 10401014-11 1999 Patients with inadequately low PTH levels (relative hypoparathyroidism, PTH < 120 pg/mL; n = 52) showed greater serum Mg concentrations than the rest (n = 58; 3.01 +/- 0.33 v 2.63 +/- 0.38 mg/dL; P < 0.001). Magnesium 121-123 parathyroid hormone Homo sapiens 72-75 10401014-12 1999 In conclusion, serum Mg concentrations in dialysis patients are independently associated with PTH levels, suggesting that chronic hypermagnesemia may decrease PTH secretion and/or synthesis. Magnesium 21-23 parathyroid hormone Homo sapiens 94-97 10401014-12 1999 In conclusion, serum Mg concentrations in dialysis patients are independently associated with PTH levels, suggesting that chronic hypermagnesemia may decrease PTH secretion and/or synthesis. Magnesium 21-23 parathyroid hormone Homo sapiens 159-162 10431997-10 1999 The peak serum levels of interleukin-6 (IL-6) were significantly lower in the magnesium group than those in the placebo group (38.9 +/- 25.0 vs 92.3 +/- 76.5 pg/mL, p = 0.016). Magnesium 78-87 interleukin 6 Homo sapiens 40-44 10364292-7 1999 Magnesium or zinc ions are required for the association of Tat with the kinase. Magnesium 0-9 tyrosine aminotransferase Homo sapiens 59-62 10406802-9 1999 This localization suggests that AtMHX may control the partitioning of Mg(2+) and Zn(2+) between the various plant organs. Magnesium 70-72 magnesium/proton exchanger Arabidopsis thaliana 32-37 10373448-4 1999 Upon re-examining the effect of PI4,5P2 on the actin and talin-binding activities of intact vinculin, we find that when the experimental design controls for the effect of magnesium on aggregation of PI4,5P2 micelles, polyphosphoinositides promote interactions with the talin-binding domain, but block interactions of the actin-binding domain. Magnesium 171-180 vinculin Homo sapiens 92-100 10380851-8 1999 Our results suggest that the absence of dystrophin may facilitate NMDAr activation in the CA1 hippocampal subfield of mdx mice, which may be partly due to a reduction of the voltage-dependent block of this receptor by magnesium. Magnesium 218-227 dystrophin, muscular dystrophy Mus musculus 40-50 10380851-8 1999 Our results suggest that the absence of dystrophin may facilitate NMDAr activation in the CA1 hippocampal subfield of mdx mice, which may be partly due to a reduction of the voltage-dependent block of this receptor by magnesium. Magnesium 218-227 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 66-71 10380851-8 1999 Our results suggest that the absence of dystrophin may facilitate NMDAr activation in the CA1 hippocampal subfield of mdx mice, which may be partly due to a reduction of the voltage-dependent block of this receptor by magnesium. Magnesium 218-227 carbonic anhydrase 1 Mus musculus 90-93 10373448-4 1999 Upon re-examining the effect of PI4,5P2 on the actin and talin-binding activities of intact vinculin, we find that when the experimental design controls for the effect of magnesium on aggregation of PI4,5P2 micelles, polyphosphoinositides promote interactions with the talin-binding domain, but block interactions of the actin-binding domain. Magnesium 171-180 serpin family A member 4 Homo sapiens 199-206 10402815-1 1999 In order to evaluate the effect of intra-operative blood transfusion on post-operative decrease of ionized Mg (Mg2+), we performed following studies. Magnesium 107-109 mucin 7, secreted Homo sapiens 111-114 10369661-3 1999 Here we report the crystal structure of human GS (hGS) at 2.1 A resolution in complex with ADP, two magnesium ions, a sulfate ion and glutathione. Magnesium 100-109 hepatocyte growth factor-regulated tyrosine kinase substrate Homo sapiens 46-48 10369661-3 1999 Here we report the crystal structure of human GS (hGS) at 2.1 A resolution in complex with ADP, two magnesium ions, a sulfate ion and glutathione. Magnesium 100-109 hepatocyte growth factor-regulated tyrosine kinase substrate Homo sapiens 50-53 10357321-7 1999 Compared with the control group, magnesium prolonged the in vitro bleeding time (22%) and inhibited ADP- and collagen-induced platelet aggregation (13% and 17%), platelet P-selectin expression (18%), and the binding of fibrinogen to the platelet glycoprotein IIb/IIIa receptor (10%). Magnesium 33-42 selectin P Homo sapiens 171-181 10357321-7 1999 Compared with the control group, magnesium prolonged the in vitro bleeding time (22%) and inhibited ADP- and collagen-induced platelet aggregation (13% and 17%), platelet P-selectin expression (18%), and the binding of fibrinogen to the platelet glycoprotein IIb/IIIa receptor (10%). Magnesium 33-42 fibrinogen beta chain Homo sapiens 219-229 10357321-8 1999 Magnesium also led to significant dose-dependent inhibition of platelet aggregation (19%), P-selectin expression (14%), and fibrinogen binding (11%) before and after surgery in vitro. Magnesium 0-9 selectin P Homo sapiens 91-101 10357321-8 1999 Magnesium also led to significant dose-dependent inhibition of platelet aggregation (19%), P-selectin expression (14%), and fibrinogen binding (11%) before and after surgery in vitro. Magnesium 0-9 fibrinogen beta chain Homo sapiens 124-134 10381152-0 1999 Growth hormone corrects acidosis-induced renal nitrogen wasting and renal phosphate depletion and attenuates renal magnesium wasting in humans. Magnesium 115-124 growth hormone 1 Homo sapiens 0-14 10381152-11 1999 Acidosis also induced hypomagnesemia and hypermagnesuria (cumulative loss, 9.4 mmol, ie, renal magnesium wasting), a novel finding, which was significantly attenuated by GH (cumulative retention, 5.0 mmol). Magnesium 95-104 growth hormone 1 Homo sapiens 170-172 10738183-0 1999 Magnesium fortification of drinking water suppresses atherogenesis in male LDL-receptor-deficient mice. Magnesium 0-9 low density lipoprotein receptor Mus musculus 75-87 10738183-12 1999 These results confirm that magnesium fortification of drinking water is capable of inhibiting atherogenesis in male LDL-receptor-deficient mice. Magnesium 27-36 low density lipoprotein receptor Mus musculus 116-128 10352100-5 1999 Here we demonstrate that the transcript for ERbeta can be detected in the human osteosarcoma cell lines (MG-63 and SaOS-2) and in cultured human osteoblast-like cells. Magnesium 105-107 estrogen receptor 2 Homo sapiens 44-50 10231437-5 1999 In addition, [Ca2+]i levels and IP1 generation were enhanced in a dose-dependent fashion by additions of the CaSR agonists calcium (Ca2+), magnesium (Mg2+), gadolinium (Gd3+), and neomycin only in cells transfected with CaSR. Magnesium 139-148 calcium sensing receptor Homo sapiens 109-113 10513211-8 1999 The hydrophobicity in the calcification was similar to that at other sites, and was negatively associated with Ca and Mg in the elastin fraction. Magnesium 118-120 elastin Homo sapiens 128-135 10406202-0 1999 Chromatographic study of magnesium and calcium binding to immobilized human serum albumin. Magnesium 25-34 albumin Homo sapiens 76-89 10404736-3 1999 However, using mean values obtained over the study period, a direct relationship was observed between the excretion of both calcium and magnesium and HbA1 in female patients (P < 0.01) but not in males who had similar HbA1 values. Magnesium 136-145 hemoglobin subunit alpha 1 Homo sapiens 150-154 10231437-5 1999 In addition, [Ca2+]i levels and IP1 generation were enhanced in a dose-dependent fashion by additions of the CaSR agonists calcium (Ca2+), magnesium (Mg2+), gadolinium (Gd3+), and neomycin only in cells transfected with CaSR. Magnesium 139-148 calcium sensing receptor Homo sapiens 220-224 10220355-1 1999 In addition to a magnesium ion needed to form the ATP-Mg complex, we have previously determined that at least one more free Mg2+ ion is essential for the activation of the protein tyrosine kinase, Csk [Sun, G., and Budde, R. J. Magnesium 17-26 C-terminal Src kinase Homo sapiens 197-200 10220355-1 1999 In addition to a magnesium ion needed to form the ATP-Mg complex, we have previously determined that at least one more free Mg2+ ion is essential for the activation of the protein tyrosine kinase, Csk [Sun, G., and Budde, R. J. Magnesium 54-56 C-terminal Src kinase Homo sapiens 197-200 10191266-4 1999 Phosphorylation-induced release of Ca2+ from the ATPase is biphasic at alkaline pH, which is consistent with sequential release of Ca2+ from the phosphorylated ATPase; the rates of both components decrease with increasing Mg concentration. Magnesium 222-224 carbonic anhydrase 2 Homo sapiens 35-38 10191266-4 1999 Phosphorylation-induced release of Ca2+ from the ATPase is biphasic at alkaline pH, which is consistent with sequential release of Ca2+ from the phosphorylated ATPase; the rates of both components decrease with increasing Mg concentration. Magnesium 222-224 dynein axonemal heavy chain 8 Homo sapiens 49-55 10191266-4 1999 Phosphorylation-induced release of Ca2+ from the ATPase is biphasic at alkaline pH, which is consistent with sequential release of Ca2+ from the phosphorylated ATPase; the rates of both components decrease with increasing Mg concentration. Magnesium 222-224 carbonic anhydrase 2 Homo sapiens 131-134 10381152-14 1999 GH attenuated acidosis-induced renal magnesium wasting. Magnesium 37-46 growth hormone 1 Homo sapiens 0-2 10187863-1 1999 Activation of magnesium-dependent neutral sphingomyelinase via caspase-3. Magnesium 14-23 sphingomyelin phosphodiesterase 2 Homo sapiens 34-58 10187863-1 1999 Activation of magnesium-dependent neutral sphingomyelinase via caspase-3. Magnesium 14-23 caspase 3 Homo sapiens 63-72 10187863-5 1999 SNP also decreased the sphingomyelin level to approximately 70% of the control level and increased magnesium-dependent neutral sphingomyelinase (N-SMase) activity to 160% of the control activity 2 h after treatment. Magnesium 99-108 sphingomyelin phosphodiesterase 2 Homo sapiens 119-143 10187863-5 1999 SNP also decreased the sphingomyelin level to approximately 70% of the control level and increased magnesium-dependent neutral sphingomyelinase (N-SMase) activity to 160% of the control activity 2 h after treatment. Magnesium 99-108 sphingomyelin phosphodiesterase 2 Homo sapiens 145-152 10187863-10 1999 These results suggest that the findings that SNP increased ceramide generation and magnesium-dependent N-SMase activity via caspase-3 are interesting to future study to determine the relation between caspases and sphingolipid metabolites in NO-mediated signaling. Magnesium 83-92 sphingomyelin phosphodiesterase 2 Homo sapiens 103-110 10187863-10 1999 These results suggest that the findings that SNP increased ceramide generation and magnesium-dependent N-SMase activity via caspase-3 are interesting to future study to determine the relation between caspases and sphingolipid metabolites in NO-mediated signaling. Magnesium 83-92 caspase 3 Homo sapiens 124-133 10102936-2 1999 Previous studies have attributed the rectification properties of strong inward rectifiers such as Kir2.1 to voltage-dependent binding of intracellular polyamines or Mg to the pore (direct open channel block), thereby preventing outward passage of K ions. Magnesium 165-167 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 98-104 10225217-2 1999 Basic fibroblast growth factor (bFGF) has been shown to be neuroprotective against excitotoxic, ischemic, and traumatic injury to the CNS, while acute posttraumatic treatment with magnesium (Mg2+) has been shown to decrease the motor and cognitive deficits following experimental brain injury. Magnesium 180-189 fibroblast growth factor 2 Rattus norvegicus 0-30 10225217-2 1999 Basic fibroblast growth factor (bFGF) has been shown to be neuroprotective against excitotoxic, ischemic, and traumatic injury to the CNS, while acute posttraumatic treatment with magnesium (Mg2+) has been shown to decrease the motor and cognitive deficits following experimental brain injury. Magnesium 180-189 fibroblast growth factor 2 Rattus norvegicus 32-36 10218382-3 1999 The plasma magnesium level has been shown to be inversely related to insulin sensitivity. Magnesium 11-20 insulin Homo sapiens 69-76 10218382-4 1999 Magnesium supplementation improves insulin sensitivity as well as insulin secretion in patients with type 2 diabetes. Magnesium 0-9 insulin Homo sapiens 35-42 10413917-1 1999 UNLABELLED: The acute phase response (APR) is characterized by proteolysis with decreased body cell mass, hyperglycemia, body water retention and renal dysfunction, which we hypothesised could affect magnesium serum levels. Magnesium 200-209 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 38-41 10413917-2 1999 The aim of this study was to compare serum magnesium levels among hospitalized patients with or without APR. Magnesium 43-52 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 104-107 10413917-10 1999 Serum magnesium levels (median; range) were higher among APR [symbol: see text] cases, when compared to APR theta ones: 1.75; 1-3 vs 1.6; 0.9-2.9 m/dl, the same occurring with glycemia (115; 49-236 vs 99; 61-191 mg/dl) and serum creatinine (mean +/- SD): 0.8840 +/- 306 vs 0.803 +/- 0.257 mg/dl. Magnesium 6-15 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 57-60 10413917-12 1999 CONCLUSIONS: Our results suggest that higher magnesium serum levels seen in APR [symbol: see text] patients may be attributed to subclinical renal ischemia and possibly to increased glucose serum levels. Magnesium 45-54 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 76-79 10051574-2 1999 The ATP-dependent insertion of magnesium into protoporphyrin IX is catalyzed by the enzyme Mg-chelatase, which consists of three protein subunits (CHL D, CHL I, and CHL H). Magnesium 31-40 magnesium-chelatase subunit ChlI, chloroplastic Nicotiana tabacum 154-159 10051574-2 1999 The ATP-dependent insertion of magnesium into protoporphyrin IX is catalyzed by the enzyme Mg-chelatase, which consists of three protein subunits (CHL D, CHL I, and CHL H). Magnesium 31-40 magnesium-chelatase subunit ChlH, chloroplastic Nicotiana tabacum 165-170 10191266-4 1999 Phosphorylation-induced release of Ca2+ from the ATPase is biphasic at alkaline pH, which is consistent with sequential release of Ca2+ from the phosphorylated ATPase; the rates of both components decrease with increasing Mg concentration. Magnesium 222-224 dynein axonemal heavy chain 8 Homo sapiens 160-166 9880491-14 1999 A time course change in the scattering profiles arising from magnesium activation of the FEN-1.34-mer DNA flap complex is consistent with the protein completely releasing the DNA substrate after cleavage. Magnesium 61-70 flap structure-specific endonuclease 1 Homo sapiens 89-94 10405461-1 1999 The MGH and MGL mouse lines, genetically selected for high and low blood magnesium (Mg) levels, respectively, exhibit marked differences for characteristics expected to be related to blood Mg levels, such as increased stress sensitivity and stress-induced aggressivity in MGL mice. Magnesium 73-82 C-type lectin domain family 10, member A Mus musculus 12-15 10405461-1 1999 The MGH and MGL mouse lines, genetically selected for high and low blood magnesium (Mg) levels, respectively, exhibit marked differences for characteristics expected to be related to blood Mg levels, such as increased stress sensitivity and stress-induced aggressivity in MGL mice. Magnesium 84-86 C-type lectin domain family 10, member A Mus musculus 12-15 10405461-1 1999 The MGH and MGL mouse lines, genetically selected for high and low blood magnesium (Mg) levels, respectively, exhibit marked differences for characteristics expected to be related to blood Mg levels, such as increased stress sensitivity and stress-induced aggressivity in MGL mice. Magnesium 189-191 C-type lectin domain family 10, member A Mus musculus 12-15 10405461-3 1999 The MGH-MGL lines may, therefore, provide a beneficial and complementary model for the study of the relationships between audiogenic seizures and blood Mg levels. Magnesium 152-154 C-type lectin domain family 10, member A Mus musculus 8-11 10072228-2 1999 The Dead Sea, the lowest site on earth, is distinguished by natural oxygen enrichment, low humidity, high barometric pressure, and temperature with increased bromide and magnesium concentrations in the inspired air. Magnesium 170-179 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 9-12 10090339-6 1999 Our results seem to indicate that the insulin resistance status, the hyperglycemia, and the disregulation of the adrenergic system in obese subjects could be involved in the pathogenesis of the magnesium homeostasis impairment observed in the obese subjects. Magnesium 194-203 insulin Homo sapiens 38-45 10095951-0 1999 [Tap water magnesium deficiency modulate arterial blood pressure, Ca and Mg tissue distribution, and compartmentation of membrane-bound calcium in thrombocytes of normotensive WKY rats]. Magnesium 11-20 nuclear RNA export factor 1 Rattus norvegicus 1-4 10095951-0 1999 [Tap water magnesium deficiency modulate arterial blood pressure, Ca and Mg tissue distribution, and compartmentation of membrane-bound calcium in thrombocytes of normotensive WKY rats]. Magnesium 73-75 nuclear RNA export factor 1 Rattus norvegicus 1-4 10028924-0 1999 Modulation of HERG potassium channels by extracellular magnesium and quinidine. Magnesium 55-64 potassium voltage-gated channel subfamily H member 2 Homo sapiens 14-18 10028924-5 1999 This study was designed to investigate the effects of extracellular magnesium (Mg2+) on HERG potassium currents. Magnesium 68-77 potassium voltage-gated channel subfamily H member 2 Homo sapiens 88-92 9918544-3 1999 In membranes containing 100 microM magnesium, (2-amino-4, 5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone (PD 81, 723) significantly increased the affinity of the adenosine A1 receptor agonist, cyclopentyladenosine, for the low-affinity receptor without affecting high-affinity binding or Bmax. Magnesium 35-44 adenosine receptor A1 Cricetulus griseus 174-195 10205895-5 1999 The AtAHL and AtSAL2 cDNAs complement the auxotrophy for methionine of the yeast hal2 mutant and the recombinant proteins catalyse the conversion of PAP to AMP in a Mg(2+)-dependent reaction sensitive to inhibition by Ca2+ and Li+. Magnesium 165-167 HAL2-like protein Arabidopsis thaliana 4-9 10205895-5 1999 The AtAHL and AtSAL2 cDNAs complement the auxotrophy for methionine of the yeast hal2 mutant and the recombinant proteins catalyse the conversion of PAP to AMP in a Mg(2+)-dependent reaction sensitive to inhibition by Ca2+ and Li+. Magnesium 165-167 Inositol monophosphatase family protein Arabidopsis thaliana 14-20 10205895-5 1999 The AtAHL and AtSAL2 cDNAs complement the auxotrophy for methionine of the yeast hal2 mutant and the recombinant proteins catalyse the conversion of PAP to AMP in a Mg(2+)-dependent reaction sensitive to inhibition by Ca2+ and Li+. Magnesium 165-167 3'(2'),5'-bisphosphate nucleotidase Saccharomyces cerevisiae S288C 81-85 9852075-2 1998 The RNA triphosphatase activity of Cet1p is magnesium-dependent and has a turnover number of 1 s-1. Magnesium 44-53 polynucleotide 5'-phosphatase Saccharomyces cerevisiae S288C 35-40 10206097-7 1999 Serum Mg levels were transiently increased after operation (+0.25 mmol/L, p<0.001) and correlated to the TNF-alpha (r=0.62, p <0.01) and PCT (r=0.67, p < 0.006) levels in the morning after surgery. Magnesium 6-8 tumor necrosis factor Homo sapiens 108-117 9989242-6 1999 The conformation of SP-A is altered by the presence of cations, especially calcium, then sodium, and to a small extent, magnesium. Magnesium 120-129 pulmonary surfactant-associated protein A Bos taurus 20-24 9989243-0 1999 Enhanced tumor necrosis factor-alpha production following endotoxin challenge in rats is an early event during magnesium deficiency. Magnesium 111-120 tumor necrosis factor Rattus norvegicus 9-36 9989243-7 1999 A significant increase in TNF alpha plasma level was observed in Mg-deficient rats compared to rats fed the control diet. Magnesium 65-67 tumor necrosis factor Rattus norvegicus 26-35 9989243-8 1999 Mg-deficient rats that received magnesium replacement therapy before endotoxin challenge had significantly lower TNF alpha plasma values than those receiving saline before endotoxin. Magnesium 0-2 tumor necrosis factor Rattus norvegicus 113-122 9989243-8 1999 Mg-deficient rats that received magnesium replacement therapy before endotoxin challenge had significantly lower TNF alpha plasma values than those receiving saline before endotoxin. Magnesium 32-41 tumor necrosis factor Rattus norvegicus 113-122 10416029-6 1999 Also, CoQ10 addition decreased ceramide release after serum withdrawal by inhibition of magnesium-dependent plasma membrane neutral-sphingomyelinase. Magnesium 88-97 sphingomyelin phosphodiesterase 2 Homo sapiens 124-148 10191369-2 1999 In capillary, microvascular, and macrovascular endothelial cells, Mg dobesilate incubation (0.25-1 mM) for 24 hours led to a highly significant concentration-correlating increase in ecNOS activities. Magnesium 66-68 nitric oxide synthase 3 Homo sapiens 182-187 9867812-5 1999 In the presence of magnesium, the dissociation rates of the complexes with C.AP and SMeG.AP are increased more than 20-fold, allowing each thymine DNA glycosylase to remove more than one uracil or thymine from C.U and SMeG.T mismatches in DNA. Magnesium 19-28 thymine DNA glycosylase Homo sapiens 139-162 10780407-0 1999 Does 29-mer RNA hairpin of the HIV-1 TAR RNA sequence bind magnesium? Magnesium 59-68 RNA binding motif protein 8A Homo sapiens 37-40 10780407-6 1999 The unmodified HIV-1 TAR RNA hairpin resulted from 600 ps in aqua molecular dynamics simulation was subjected to a molecular mechanics modelling of Mg+ binding. Magnesium 148-151 RNA binding motif protein 8A Homo sapiens 21-24 9922138-1 1998 The metals of the cytochrome c oxidase structures of the bovine heart mitochondrion (PDB code 1occ) and of the soil bacterium Paracoccus denitrificans (1arl) include a dicopper center (CuA), magnesium, two proximal hemes, a copper (CuB) atom, and a calcium. Magnesium 191-200 cytochrome c, somatic Homo sapiens 18-30 9922138-6 1998 Our analysis uncovers several statistically significant residue clusters, including a cysteine-histidine-tyrosine cluster overlapping the CuA-Mg complex; a histidine-acidic cluster enveloping the environment of Mg, the two hemes, and CuB; and on the protein surface a mixed charge cluster, which may help stabilize the quaternary structure and/or mediate docking to cytochrome c. Magnesium 211-213 cytochrome c, somatic Homo sapiens 366-378 10082941-1 1999 Magnesium (Mg2+) is the physiological divalent cation stabilizing nucleotide or nucleotide analog in the active site of myosin subfragment 1 (S1). Magnesium 0-9 proteasome 26S subunit, non-ATPase 1 Homo sapiens 142-144 10082941-3 1999 The ATPase inactivation rate of the magnesium trapped S1 is comparable but smaller than the other known gamma-phosphate analogs at 1.2 M-1 s-1 with 1 mM MgCl2. Magnesium 36-45 proteasome 26S subunit, non-ATPase 1 Homo sapiens 54-56 10082941-4 1999 The observed molar ratio of Mg/S1 in this complex of 1.58 suggests that magnesium occupies the gamma-phosphate position in the ATP binding site of S1 (S1-MgADP-MgFx). Magnesium 72-81 proteasome 26S subunit, non-ATPase 1 Homo sapiens 31-33 10082941-4 1999 The observed molar ratio of Mg/S1 in this complex of 1.58 suggests that magnesium occupies the gamma-phosphate position in the ATP binding site of S1 (S1-MgADP-MgFx). Magnesium 72-81 proteasome 26S subunit, non-ATPase 1 Homo sapiens 151-164 9851785-0 1998 Magnesium responsiveness to insulin and insulin-like growth factor I in erythrocytes from normotensive and hypertensive subjects. Magnesium 0-9 insulin Homo sapiens 28-35 9836597-0 1998 Autophosphorylation and protein kinase activity of p21-activated protein kinase gamma-PAK are differentially affected by magnesium and manganese. Magnesium 121-130 serine/threonine-protein kinase PAK 2 Oryctolagus cuniculus 80-89 9836597-3 1998 The rate of autophosphorylation with ATP(Mn) was 4.7-fold faster than with ATP(Mg) alone and was stimulated 2-fold by Cdc42(GTPgammaS). Magnesium 79-81 cell division control protein 42 homolog Oryctolagus cuniculus 118-123 9831080-4 1998 Receptor-mediated signals such as ATP, IFN-alpha, or PGE1, which can trigger cAMP-dependent magnesium efflux, were ineffective in undifferentiated HL-60 cells but induced 60-70% increase of magnesium efflux in neutrophyl-like HL-60 cells. Magnesium 92-101 interferon alpha 1 Homo sapiens 39-48 9831080-4 1998 Receptor-mediated signals such as ATP, IFN-alpha, or PGE1, which can trigger cAMP-dependent magnesium efflux, were ineffective in undifferentiated HL-60 cells but induced 60-70% increase of magnesium efflux in neutrophyl-like HL-60 cells. Magnesium 190-199 interferon alpha 1 Homo sapiens 39-48 9891842-3 1998 The experiments were performed both under conditions assuring saturation of RLC with magnesium cation (4 mM EGTA) or calcium cation (0.1 mM CaCl2), and in constant presence of 1 mM magnesium chloride. Magnesium 85-94 integrin subunit alpha 9 Homo sapiens 76-79 9831080-9 1998 Stimuli that triggered magnesium efflux, such as db cAMP in undifferentiated and IFN-alpha in neutrophyl-like HL-60 cells, induced a slow but consistent increase of [Mg2+]i which was independent from Ca2+ movements. Magnesium 23-32 interferon alpha 1 Homo sapiens 81-90 9851785-0 1998 Magnesium responsiveness to insulin and insulin-like growth factor I in erythrocytes from normotensive and hypertensive subjects. Magnesium 0-9 insulin like growth factor 1 Homo sapiens 40-68 9851785-10 1998 Together, these data support a role for IGF-I in cellular magnesium metabolism and emphasize the importance of magnesium as a determinant of insulin action. Magnesium 58-67 insulin like growth factor 1 Homo sapiens 40-45 9851785-10 1998 Together, these data support a role for IGF-I in cellular magnesium metabolism and emphasize the importance of magnesium as a determinant of insulin action. Magnesium 111-120 insulin Homo sapiens 141-148 9804799-0 1998 Rapid dissociation of human apurinic endonuclease (Ape1) from incised DNA induced by magnesium. Magnesium 85-94 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 51-55 9804799-5 1998 Magnesium at low to moderate concentrations accelerated both substrate and product release by wild-type Ape1 protein. Magnesium 0-9 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 104-108 9804799-7 1998 The magnesium dependence of steady-state AP endonuclease reactions was sigmoidal for both wild-type and the aspartate 308 to alanine protein but was not sigmoidal for an aspartate 283 to alanine derivative of Ape1. Magnesium 4-13 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 209-213 9804799-8 1998 These results show that magnesium affects both DNA interactions with and phosphodiester cleavage by Ape1 and can change the rate-limiting step of the reaction. Magnesium 24-33 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 100-104 9786869-7 1998 When gamma-PAK is autophosphorylated with ATP(Mg) alone and then cleaved, only p27 contains phosphate, and the enzyme is inactive with exogenous substrate. Magnesium 46-48 p21 (RAC1) activated kinase 2 Homo sapiens 5-14 9786869-7 1998 When gamma-PAK is autophosphorylated with ATP(Mg) alone and then cleaved, only p27 contains phosphate, and the enzyme is inactive with exogenous substrate. Magnesium 46-48 dynactin subunit 6 Homo sapiens 79-82 9828151-0 1998 Effects of insulin and insulin-like growth factor-1 on intracellular magnesium of platelets. Magnesium 69-78 insulin Homo sapiens 11-18 29711341-0 1998 Magnesium Complexes Bearing eta2 -Pyrazolato Ligands. Magnesium 0-9 DNA polymerase iota Homo sapiens 28-32 9784918-0 1998 Acute lithium administration impairs the action of parathyroid hormone on rat renal calcium, magnesium and phosphate transport. Magnesium 93-102 parathyroid hormone Rattus norvegicus 51-70 9828151-0 1998 Effects of insulin and insulin-like growth factor-1 on intracellular magnesium of platelets. Magnesium 69-78 insulin like growth factor 1 Homo sapiens 23-51 9768650-6 1998 During the second half of the day (12-24 h), twice-daily PTH increased serum calcium and magnesium levels more effectively than once-daily PTH. Magnesium 89-98 parathyroid hormone Homo sapiens 57-60 9782065-11 1998 Ability of Mg, diltiazem and leumedins to decrease the ET-1 plasma level may have direct clinical implications for the use of these agents in patients with coronary artery disease. Magnesium 11-13 endothelin 1 Homo sapiens 55-59 9809619-5 1998 Calcium-independent cytokine induction using anti-CD28 and PMA resulted in production of both cytokines, whereas depletion of extracellular calcium and magnesium adversely influenced the yield of both IL-4 and IFN-gamma. Magnesium 152-161 interleukin 4 Homo sapiens 201-205 9809619-5 1998 Calcium-independent cytokine induction using anti-CD28 and PMA resulted in production of both cytokines, whereas depletion of extracellular calcium and magnesium adversely influenced the yield of both IL-4 and IFN-gamma. Magnesium 152-161 interferon gamma Homo sapiens 210-219 9755863-7 1998 Efficient cleavage of eIF-4G requires magnesium ions. Magnesium 38-47 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 22-28 9755863-8 1998 The presence of other initiation factors such as eIF-3, eIF-4A or eIF-4B mimics in part the stimulatory effect of magnesium ions and probably stabilizes the cleavage products of eIF-4G generated by 2Apro. Magnesium 114-123 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 178-184 9804396-9 1998 In the patient group the fraction of ionized magnesium in the total was negatively related to the serum albumin level (r=-0.41, p<0.001). Magnesium 45-54 albumin Homo sapiens 104-111 30636864-8 1998 Potentially mediating nutrients explaining part of the relationship between whole grain intake and fasting insulin were dietary magnesium and fiber. Magnesium 128-137 insulin Homo sapiens 107-114 9706868-0 1998 Magnesium restriction induces granulocytic differentiation and expression of p27Kip1 in human leukemic HL-60 cells. Magnesium 0-9 cyclin dependent kinase inhibitor 1B Homo sapiens 77-84 9800683-0 1998 The high calcium ion uptake capacity of Ehrlich ascites tumour cell mitochondria is due to inhibition of the permeability transition and phospholipase A2 activity by magnesium. Magnesium 166-175 phospholipase A2, group IB, pancreas Mus musculus 137-153 9675261-4 1998 Initial velocity data from detailed kinetic studies, in which the concentrations of free and Mg-complexed PEP and phosphomycin were controlled, are consistent with: (1) the true activator is free phosphomycin, which competes with free PEP for the Glc6P-allosteric site; and (2) the Mg-phosphomycin complex caused inhibition by binding to the active site in competition with MgPEP. Magnesium 93-95 phosphoenolpyruvate carboxylase 2 Zea mays 106-109 9705856-0 1998 The two-state process of the heat shock protein 90 thermal denaturation: effect of calcium and magnesium. Magnesium 95-104 heat shock protein 90 alpha family class A member 1 Homo sapiens 29-50 9705856-4 1998 Calcium and magnesium strongly decrease the hsp90 thermostability and thereby cause oligomerization at lower temperature. Magnesium 12-21 heat shock protein 90 alpha family class A member 1 Homo sapiens 44-49 9819712-6 1998 Urinary albumin excretion was significantly higher, and N-acetyl-beta-D-glucosaminidase activity in the urine was significantly increased in rats fed the magnesium-deficient diet. Magnesium 154-163 O-GlcNAcase Rattus norvegicus 56-87 9717944-1 1998 A summary of new findings regarding alterations of magnesium (Mg2+) and phosphorus (P) metabolism are reviewed for the clinician caring for patients in general wards. Magnesium 51-60 mucin 7, secreted Homo sapiens 62-65 9697810-5 1998 Optimal doses of MG-63 CM (50 microg/mL), insulin-like growth factor I (50 ng/mL), and transforming growth factor-beta-1 (25 ng/mL), as determined by DNA content assay, partially neutralized the adriamycin cytotoxicity of PC-3 cells detected by flow cytometry and trypan blue exclusion. Magnesium 17-19 transforming growth factor beta 1 Homo sapiens 42-120 9877232-7 1998 Since NDP kinase has been implicated in direct interaction with and/or activation of various G-proteins, we quantitated both basal and magnesium-stimulated NDP kinase activity in soluble and particulate fractions of retina derived from STZ-diabetic rats to examine whether abnormalities in G-protein function in diabetes are attributable to alterations in retinal NDP kinase. Magnesium 135-144 cytidine/uridine monophosphate kinase 1 Rattus norvegicus 6-16 9877232-7 1998 Since NDP kinase has been implicated in direct interaction with and/or activation of various G-proteins, we quantitated both basal and magnesium-stimulated NDP kinase activity in soluble and particulate fractions of retina derived from STZ-diabetic rats to examine whether abnormalities in G-protein function in diabetes are attributable to alterations in retinal NDP kinase. Magnesium 135-144 cytidine/uridine monophosphate kinase 1 Rattus norvegicus 156-166 9877232-7 1998 Since NDP kinase has been implicated in direct interaction with and/or activation of various G-proteins, we quantitated both basal and magnesium-stimulated NDP kinase activity in soluble and particulate fractions of retina derived from STZ-diabetic rats to examine whether abnormalities in G-protein function in diabetes are attributable to alterations in retinal NDP kinase. Magnesium 135-144 cytidine/uridine monophosphate kinase 1 Rattus norvegicus 156-166 9675261-4 1998 Initial velocity data from detailed kinetic studies, in which the concentrations of free and Mg-complexed PEP and phosphomycin were controlled, are consistent with: (1) the true activator is free phosphomycin, which competes with free PEP for the Glc6P-allosteric site; and (2) the Mg-phosphomycin complex caused inhibition by binding to the active site in competition with MgPEP. Magnesium 93-95 phosphoenolpyruvate carboxylase 2 Zea mays 235-238 9684873-5 1998 This structural reorganization is initiated by ATP binding followed by interconversion to the open channel structure as the CFTR-ATP-Mg complex passes to the transition state for hydrolysis. Magnesium 133-135 CF transmembrane conductance regulator Homo sapiens 124-128 9713812-0 1998 Magnesium as a regulator of thrombin formation in bovine ovarian follicular fluid. Magnesium 0-9 coagulation factor II, thrombin Bos taurus 28-36 9706387-2 1998 The NR2B subunit confers slow decay kinetics (relative to NR1/NR2A receptors) and high magnesium sensitivity to NMDA receptor responses--properties which may contribute to the NMDA receptor-mediated bursting manifested by these cells. Magnesium 87-96 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 4-8 9661575-6 1998 Postoperative analgesia was achieved with fentanyl (0.5 microgram/kg) and evaluated using the pain visual analog scale for 4 h. During the intraoperative and postoperative periods, patients in the magnesium group required significantly less fentanyl than those in the control group (control group 0.089 +/- 0.02 microgram.kg-1.min-1 versus magnesium group 0.058 +/- 0.01 microgram.kg-1.min-1; P < 0.05 and control group 0.021 +/- 0.013 microgram.kg-1.min-1 and magnesium group 0.0031 +/- 0.0018 microgram.kg-1.min-1; P < 0.01 for intraoperative and postoperative periods, respectively). Magnesium 197-206 CD59 molecule (CD59 blood group) Homo sapiens 327-332 9661575-6 1998 Postoperative analgesia was achieved with fentanyl (0.5 microgram/kg) and evaluated using the pain visual analog scale for 4 h. During the intraoperative and postoperative periods, patients in the magnesium group required significantly less fentanyl than those in the control group (control group 0.089 +/- 0.02 microgram.kg-1.min-1 versus magnesium group 0.058 +/- 0.01 microgram.kg-1.min-1; P < 0.05 and control group 0.021 +/- 0.013 microgram.kg-1.min-1 and magnesium group 0.0031 +/- 0.0018 microgram.kg-1.min-1; P < 0.01 for intraoperative and postoperative periods, respectively). Magnesium 197-206 CD59 molecule (CD59 blood group) Homo sapiens 386-391 9661575-6 1998 Postoperative analgesia was achieved with fentanyl (0.5 microgram/kg) and evaluated using the pain visual analog scale for 4 h. During the intraoperative and postoperative periods, patients in the magnesium group required significantly less fentanyl than those in the control group (control group 0.089 +/- 0.02 microgram.kg-1.min-1 versus magnesium group 0.058 +/- 0.01 microgram.kg-1.min-1; P < 0.05 and control group 0.021 +/- 0.013 microgram.kg-1.min-1 and magnesium group 0.0031 +/- 0.0018 microgram.kg-1.min-1; P < 0.01 for intraoperative and postoperative periods, respectively). Magnesium 197-206 CD59 molecule (CD59 blood group) Homo sapiens 386-391 9661575-6 1998 Postoperative analgesia was achieved with fentanyl (0.5 microgram/kg) and evaluated using the pain visual analog scale for 4 h. During the intraoperative and postoperative periods, patients in the magnesium group required significantly less fentanyl than those in the control group (control group 0.089 +/- 0.02 microgram.kg-1.min-1 versus magnesium group 0.058 +/- 0.01 microgram.kg-1.min-1; P < 0.05 and control group 0.021 +/- 0.013 microgram.kg-1.min-1 and magnesium group 0.0031 +/- 0.0018 microgram.kg-1.min-1; P < 0.01 for intraoperative and postoperative periods, respectively). Magnesium 197-206 CD59 molecule (CD59 blood group) Homo sapiens 386-391 9713812-4 1998 To determine whether the high level of Mg might function to regulate thrombin generation in FF as occurs in plasma, the influence of Mg supplementation of FF from various types of follicles was examined. Magnesium 39-41 coagulation factor II, thrombin Bos taurus 69-77 9633883-6 1998 The mechanism by which one of the anti-CD44 mAb (L178) enhanced progenitor adhesion did not involve CD44-crosslinking, and was independent of VLA-4-, VLA-5- or LFA-1-mediated interactions, Ca or Mg cations, or accessory cells. Magnesium 195-197 CD44 molecule (Indian blood group) Homo sapiens 39-43 9649318-4 1998 This study was done to understand how Cr(III), in the presence of physiological concentrations of magnesium, affects the kinetic parameters of steady-state DNA synthesis in vitro across site-specific O6-methylguanine (m6dG) residues by DNA polymerase beta (pol beta). Magnesium 98-107 DNA polymerase beta Homo sapiens 236-255 9641061-2 1998 Patients with COLD may develop Mg depletion due to inadequate nutrition or treatment with diuretics and beta 2-agonists. Magnesium 31-33 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 104-110 10806665-1 1998 OBJECTIVE: To study the changes of calcium and magnesium levels in patients with pregnancy induced hypertension (PIH) and the therapeutic effect of magnesium sulfate (MgSO4). Magnesium 47-56 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 113-116 10806665-5 1998 CONCLUSION: Magnesium deficiency is the basis of calcium and magnesium disturbances in PIH, and MgSO4 treatment may improve the situation effectively. Magnesium 12-21 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 87-90 10806665-5 1998 CONCLUSION: Magnesium deficiency is the basis of calcium and magnesium disturbances in PIH, and MgSO4 treatment may improve the situation effectively. Magnesium 61-70 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 87-90 9539373-1 1998 Mimicking in rats the reduced level of dietary magnesium (Mg) intake, seen in present-day Western World populations, short-term (4 weeks) restriction of Mg intake (30-35% normal) resulted in a 40% loss in brain intracellular free Mg2+ ions ([Mg2+]i) and significant rises in brain intracellular pH (pHi) and phosphocreatine ([PCr]) but no change in [ATP] or [Pi] as measured by 31P-NMR spectroscopy. Magnesium 153-155 glucose-6-phosphate isomerase Rattus norvegicus 299-302 9544975-4 1998 The effects of magnesium (Mg), diltiazem, and a Mac-1 inhibitor on the level of Fn were elucidated. Magnesium 15-24 fibronectin 1 Homo sapiens 80-82 9544975-10 1998 Ability of Mg, diltiazem, and leumedins to modulate plasma Fn level may have direct clinical implications for the use of these agents in patients with coronary artery disease. Magnesium 11-13 fibronectin 1 Homo sapiens 59-61 9790249-0 1998 Effects of insulin on intracellular magnesium of platelets. Magnesium 36-45 insulin Homo sapiens 11-18 9666355-6 1998 Regardless of the mechanisms at stake, the MGH and MGL strains appear to constitute a new model for the study of the relationships between reproductive longevity and blood Mg levels. Magnesium 172-174 C-type lectin domain family 10, member A Mus musculus 51-54 9499453-4 1998 Different gp130 clones were express ed only by Saos-2 and MG-63 cell lines. Magnesium 58-60 interleukin 6 cytokine family signal transducer Homo sapiens 10-15 9604603-6 1998 Serum magnesium levels had significant correlations with height for age and serum albumin. Magnesium 6-15 albumin Homo sapiens 76-89 9510205-3 1998 We report here that mannan-coated MBL-sensitized erythrocytes are lysed via the lectin pathway in human serum-Mg-EGTA. Magnesium 110-112 mannose binding lectin 2 Homo sapiens 34-37 9537523-0 1998 ABI1 of Arabidopsis is a protein serine/threonine phosphatase highly regulated by the proton and magnesium ion concentration. Magnesium 97-106 Protein phosphatase 2C family protein Arabidopsis thaliana 0-4 9537523-3 1998 The ABI1 protein (ABI1p) has been characterized as a protein serine/threonine phosphatase of type 2C that is highly affected in its activity by changes in the proton and magnesium ion concentrations. Magnesium 170-179 Protein phosphatase 2C family protein Arabidopsis thaliana 4-8 9537523-3 1998 The ABI1 protein (ABI1p) has been characterized as a protein serine/threonine phosphatase of type 2C that is highly affected in its activity by changes in the proton and magnesium ion concentrations. Magnesium 170-179 Protein phosphatase 2C family protein Arabidopsis thaliana 18-23 9595547-6 1998 Primary magnesium depletion is due to dysregulation of factors controlling magnesium status: intestinal magnesium hypoabsorption, reduced magnesium bone uptake and mobilisation, sometimes urinary leakage, hyperadrenoglucocorticism by decreased adaptability to stress, insulin-resistance and adrenergic hyporeceptivity. Magnesium 8-17 insulin Homo sapiens 268-275 9491871-8 1998 Significant inhibition of CD62 and CD63 expression first occurred at a magnesium concentration of 4 mg/dL in the normal pregnant group (P < .05), at 6 mg/dL in the preeclamptic group (P < .05), and at 8 mg/dL in the nonpregnant group (P < .05). Magnesium 71-80 selectin P Homo sapiens 26-30 9491871-8 1998 Significant inhibition of CD62 and CD63 expression first occurred at a magnesium concentration of 4 mg/dL in the normal pregnant group (P < .05), at 6 mg/dL in the preeclamptic group (P < .05), and at 8 mg/dL in the nonpregnant group (P < .05). Magnesium 71-80 CD63 molecule Homo sapiens 35-39 9485302-0 1998 X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution. Magnesium 70-72 Kar3p Saccharomyces cerevisiae S288C 37-41 9614853-13 1998 The action of MT1 was inhibited by the aliphatic polyamine, spermine, as well as magnesium both at physiological concentrations. Magnesium 81-90 metallothionein 1 Rattus norvegicus 14-17 9486227-1 1998 Glucagon and arginine vasopressin (AVP) enhance renal magnesium conservation through actions within the loop of Henle and the distal tubule. Magnesium 54-63 arginine vasopressin Mus musculus 35-38 9486227-12 1998 These studies demonstrate that glucagon and AVP stimulate Mg2+ uptake in MDCT cells and suggest that these hormones act to control magnesium conservation in the convoluted segment of the distal tubule. Magnesium 131-140 arginine vasopressin Mus musculus 44-47 9632126-0 1998 Oral magnesium supplementation in insulin-requiring Type 2 diabetic patients. Magnesium 5-14 insulin Homo sapiens 34-41 9632126-1 1998 Oral magnesium (Mg) supplementation can improve insulin sensitivity and secretion in patients with Type 2 diabetes mellitus (DM). Magnesium 5-14 insulin Homo sapiens 48-55 9632126-1 1998 Oral magnesium (Mg) supplementation can improve insulin sensitivity and secretion in patients with Type 2 diabetes mellitus (DM). Magnesium 16-18 insulin Homo sapiens 48-55 9632126-2 1998 We studied the effect of Mg supplementation on glycaemic control, blood pressure, and plasma lipids in insulin-requiring patients with Type 2 DM. Magnesium 25-27 insulin Homo sapiens 103-110 9632126-9 1998 Three months" oral Mg supplementation of insulin-requiring patients with Type 2 DM increased plasma Mg concentration and urinary Mg excretion but had no effect on glycaemic control or plasma lipid concentrations. Magnesium 19-21 insulin Homo sapiens 41-48 9632126-9 1998 Three months" oral Mg supplementation of insulin-requiring patients with Type 2 DM increased plasma Mg concentration and urinary Mg excretion but had no effect on glycaemic control or plasma lipid concentrations. Magnesium 100-102 insulin Homo sapiens 41-48 9632126-9 1998 Three months" oral Mg supplementation of insulin-requiring patients with Type 2 DM increased plasma Mg concentration and urinary Mg excretion but had no effect on glycaemic control or plasma lipid concentrations. Magnesium 100-102 insulin Homo sapiens 41-48 9733091-2 1998 With porin-containing yeast mitochondria it is shown that (i) a significant, saturable association occurs; (ii) its extent and apparent affinity, correlated with the origin of porin, are enhanced in the presence of dextran; (iii) the binding requires Mg ions and apparently follows a complex cooperative mechanism. Magnesium 251-253 voltage dependent anion channel 1 Homo sapiens 5-10 9733091-2 1998 With porin-containing yeast mitochondria it is shown that (i) a significant, saturable association occurs; (ii) its extent and apparent affinity, correlated with the origin of porin, are enhanced in the presence of dextran; (iii) the binding requires Mg ions and apparently follows a complex cooperative mechanism. Magnesium 251-253 voltage dependent anion channel 1 Homo sapiens 176-181 11324580-4 1998 The results showed that in magnesium free artificial CSF, the intracellular calcium level of the CA1 pyramidal cells increased following application of glutamate or penicillin. Magnesium 27-36 carbonic anhydrase 1 Rattus norvegicus 97-100 9698646-4 1998 PTH treatment was associated with a significant increase of the apparent intestinal absorption of Ca, P, and Mg. Magnesium 109-111 parathyroid hormone Rattus norvegicus 0-3 9698646-7 1998 The mean Ca, P, and Mg balances, the mean contents of bone Ca, P, and Mg and the mean bone dry weights were significantly increased with PTH treatment. Magnesium 20-22 parathyroid hormone Rattus norvegicus 137-140 9698646-7 1998 The mean Ca, P, and Mg balances, the mean contents of bone Ca, P, and Mg and the mean bone dry weights were significantly increased with PTH treatment. Magnesium 70-72 parathyroid hormone Rattus norvegicus 137-140 9589224-2 1998 Several studies have suggested an association between magnesium (Mg) depletion and insulin resistance and/or reduction of insulin secretion in these cases. Magnesium 54-63 insulin Homo sapiens 83-90 9589224-2 1998 Several studies have suggested an association between magnesium (Mg) depletion and insulin resistance and/or reduction of insulin secretion in these cases. Magnesium 65-67 insulin Homo sapiens 83-90 9602161-6 1998 Calcium and magnesium ions stimulated the aminopeptidase N activity, but copper ion was rather inhibitory. Magnesium 12-21 aminopeptidase N Bombyx mori 42-58 15810310-2 1998 This results obtained indicate that high amounts of Mn, Fe and Mg are embodied in Bean and Bean-products. Magnesium 63-65 brain expressed associated with NEDD4 1 Homo sapiens 82-86 15810310-2 1998 This results obtained indicate that high amounts of Mn, Fe and Mg are embodied in Bean and Bean-products. Magnesium 63-65 brain expressed associated with NEDD4 1 Homo sapiens 91-95 15348897-2 1998 The organic acids were acetic, citric, tartaric and lactic acids, at 0.01 M and 0.001 M. The elution of zinc and magnesium was 10-1000 times greater in acid than in pure water, and correlated with the concentrations and the dissociation constants, pK1, of the acids tested. Magnesium 113-122 prokineticin 1 Homo sapiens 248-251 9587164-1 1998 An ion-selective analyzer (NOVA 8 [previously NOVA CRT], NOVA Biomedical Waltham, USA) for simultaneous measurement of the concentration of ionized magnesium (cMG2+) and pH is investigated for linearity and influence of calcium ions on the Mg2+ results in different Mg2+ aqueous solutions with/without added calcium. Magnesium 148-157 ANTXR cell adhesion molecule 2 Homo sapiens 159-163 9559659-3 1998 In the presence of magnesium ions birch profilin promoted the polymerization of actin from A:Tbeta4. Magnesium 19-28 thymosin beta 4 X-linked Homo sapiens 93-99 9510857-5 1998 A combination of POE-POP with alpha-cyclodextrin sulfate provided the required selectivity for the determination of LDL-C in serum in the presence of magnesium ions and a small amount of dextran sulfate without precipitating lipoprotein aggregates. Magnesium 150-159 component of oligomeric golgi complex 2 Homo sapiens 116-121 9568479-6 1998 GAPDH is released from erythrocyte membranes upon exposure to Mg.ATP or to NADH. Magnesium 62-64 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-5 9495860-0 1998 Effect of magnesium on calcium responses to vasopressin in vascular smooth muscle cells of spontaneously hypertensive rats. Magnesium 10-19 arginine vasopressin Rattus norvegicus 44-55 9495860-2 1998 Effects of increasing extracellular Mg++ concentration ([Mg++]e) on vasopressin (AVP)-induced [Ca++]i responses were determined in primary cultured unpassaged vascular smooth muscle cells from mesenteric and aortic vessels (representing resistance and conduit arteries, respectively) of Wistar Kyoto rats (WKY) and SHR. Magnesium 36-40 arginine vasopressin Rattus norvegicus 68-79 9457516-0 1998 Modulation of endothelin-1-induced contractions by magnesium/calcium in porcine ciliary arteries. Magnesium 51-60 endothelin 1 Homo sapiens 14-26 9473713-1 1998 Intracellular magnesium concentration ([Mg2+]i) of cultured dorsal root ganglion (DRG) neurons was measured using the magnesium indicator Mag-Fura-2/AM. Magnesium 14-23 mucin 7, secreted Homo sapiens 40-43 9457516-11 1998 CONCLUSIONS: In a mechanism which appears to be compatible with a calcium-antagonist effect, magnesium strongly modulates changes in contractile tone evoked by endothelin-1, but has no effect on bradykinin-induced relaxations. Magnesium 93-102 endothelin 1 Homo sapiens 160-172 9435217-2 1998 Interaction requires Mg ions, whereas MgATP inhibits, and inhibition is stronger in the presence of co-chaperonin GroES. Magnesium 21-23 chaperonin GroES Escherichia coli 114-119 9457516-1 1998 BACKGROUND: The present study was performed to investigate the influence of extracellular magnesium on changes in contractile tone induced by endothelin-1, and on relaxations to bradykinin in isolated porcine ciliary arteries. Magnesium 90-99 endothelin 1 Homo sapiens 142-154 9457516-6 1998 RESULTS: Contractions to endothelin-1 were reduced only in the presence of 10 mM magnesium. Magnesium 81-90 endothelin 1 Homo sapiens 25-37 9457516-8 1998 In endothelin-1-precontracted vessels, magnesium evoked complete concentration-dependent relaxations (pD2 = 3.1 +/- 0.1), which were shifted to the right by increasing extracellular concentrations of calcium (2.5 vs 5 mM, P < 0.05). Magnesium 39-48 endothelin 1 Homo sapiens 3-15 9777879-4 1998 After reviewing the acute and chronic treatments of asthma in the clinic (including emergency rooms) with magnesium compounds, and the use of such salts as supplementary agents in respiratory diseases, we suggest that the improvement in the asthmatic condition at the Dead Sea may be due to absorption of this element through the skin and via the lungs, and due to its involvement in anti-inflammatory and vasodilatatory processes. Magnesium 106-115 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 273-276 9696346-7 1998 In addition, in patients with ARSD the physiological relationship between plasma AVP concentration and urinary excretion of Ca and Mg (positive correlation), between plasma ANP level and urinary excretion of Ca and Mg (negative correlation), and between plasma ANP and AVP concentration (negative correlation), respectively, were absent. Magnesium 215-217 natriuretic peptide A Homo sapiens 173-176 9705567-2 1998 Mg depletion in humans results in hypocalcemia, low serum parathyroid hormone (PTH) and 1, 25(OH)2-vitamin D levels, as well as PTH and vitamin D resistance which may serve as mechanisms for the development of osteoporosis. Magnesium 0-2 parathyroid hormone Homo sapiens 58-77 9952286-1 1998 In order to assess the links which are claimed to exist between peripheral insulin resistance and intracellular magnesium and calcium concentrations, we measured free intralymphocyte magnesium (Mg(i)) and calcium (Ca(i)) concentrations as well as the rate constant of plasma glucose disappearance (K(itt)) after insulin injection (insulin tolerance test: ITT) in a group of 16 normotensive control subjects (NC) and 34 essential hypertensive subjects (EH). Magnesium 112-121 insulin Homo sapiens 75-82 9952286-7 1998 In a first attempt to study the relationships between insulin resistance, Mg(i) and Ca(i) in nucleated cells, the chosen index of peripheral resistance seems to be linked to intracellular free magnesium. Magnesium 193-202 insulin Homo sapiens 54-61 9705567-2 1998 Mg depletion in humans results in hypocalcemia, low serum parathyroid hormone (PTH) and 1, 25(OH)2-vitamin D levels, as well as PTH and vitamin D resistance which may serve as mechanisms for the development of osteoporosis. Magnesium 0-2 parathyroid hormone Homo sapiens 79-82 9705567-2 1998 Mg depletion in humans results in hypocalcemia, low serum parathyroid hormone (PTH) and 1, 25(OH)2-vitamin D levels, as well as PTH and vitamin D resistance which may serve as mechanisms for the development of osteoporosis. Magnesium 0-2 parathyroid hormone Homo sapiens 128-131 9705567-10 1998 PTH was suppressed in the Mg-deficient group (36 +/- 16 vs. 109 +/- 30 pg/ml in controls, p < 0.002). Magnesium 26-28 parathyroid hormone Rattus norvegicus 0-3 9622301-2 1997 3beta-HSD activity was detected by the formation of androstenedione from [3H]dehydroepiandrosterone (DHEA) in whole cell assays of human osteoblast-like cells, HOS and MG-63. Magnesium 168-170 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 0-9 9513926-0 1997 Magnesium modulates ouabain action on angiotensin II-induced aldosterone synthesis in vitro. Magnesium 0-9 angiotensinogen Homo sapiens 38-52 9513926-3 1997 Ouabain itself at high concentration (10(-5) M) in Mg++ buffer blocks AII action on aldosterone secretion on rat ZG cells and at 1000-fold lower concentrations inhibits AII-action in human cells as previously reported by us. Magnesium 51-55 NLR family pyrin domain containing 3 Homo sapiens 70-73 9513926-4 1997 When buffer Mg++ is higher (4mM) than normal (0.7 mM) in cultured human adrenal cells it decreases both basal aldosterone secretion (8.6 +/- 0.4 vs. 6.8 +/- 0.2, p < 0.001) and AII action on aldosterone (13.9 +/- 0.6 vs. 9.7 +/- 0.7 ng/10(6) cells/h, p < 0.01). Magnesium 12-16 NLR family pyrin domain containing 3 Homo sapiens 180-183 9389897-6 1997 Statistically significant increases in lecithin-cholesterol acyltransferase (EC 2.3.1.43; LCAT), HDL-cholesterol and apolipoprotein AI were also observed after Mg supplementation. Magnesium 160-162 lecithin-cholesterol acyltransferase Homo sapiens 39-75 9389897-6 1997 Statistically significant increases in lecithin-cholesterol acyltransferase (EC 2.3.1.43; LCAT), HDL-cholesterol and apolipoprotein AI were also observed after Mg supplementation. Magnesium 160-162 lecithin-cholesterol acyltransferase Homo sapiens 90-94 9389897-7 1997 A significant positive correlation was observed between the levels of LCAT and urinary Mg excretion for the experimental period (expressed as a percentage of the run-in value). Magnesium 87-89 lecithin-cholesterol acyltransferase Homo sapiens 70-74 9389897-9 1997 These results suggest that Mg supplementation may lower blood pressure through the suppression of the adrenergic activity and possible natriuresis, while also improving the serum lipids through the activation of LCAT in human subjects. Magnesium 27-29 lecithin-cholesterol acyltransferase Homo sapiens 212-216 9451824-7 1997 Other changes in the aorta of animals on the Mg-deficient diet included a significant reduction (54%, P < 0.001) in the activity of superoxide dismutase and catalase (37%, P < 0.01) and a 19% increase in net fractional rates of collagen synthesis (P < 0.05). Magnesium 45-47 catalase Rattus norvegicus 160-168 9471228-9 1997 The high plasma renin concentration hypertensive patients showed low serum magnesium concentration and high urine magnesium excretion. Magnesium 75-84 renin Homo sapiens 16-21 9471228-9 1997 The high plasma renin concentration hypertensive patients showed low serum magnesium concentration and high urine magnesium excretion. Magnesium 114-123 renin Homo sapiens 16-21 9360541-0 1997 Effect of variations in plasma magnesium concentration on resistance to insulin-mediated glucose disposal in nondiabetic subjects. Magnesium 31-40 insulin Homo sapiens 72-79 9360541-7 1997 Thus, a low Mg concentration in nondiabetic subjects was associated with relative insulin resistance, glucose intolerance, and hyperinsulinemia. Magnesium 12-14 insulin Homo sapiens 82-89 9477656-1 1997 The serum magnesium concentrations are compared between the three clinical classification categories established in 1993 by the Centers for Disease Control (CDC) (infection) by the human immunodeficiency virus) in adults, and its relation with the CD4 lymphocyte count, albumin, and pre-albumin. Magnesium 10-19 CD4 molecule Homo sapiens 248-251 9513926-5 1997 High Mg++ buffer had this effect at both 10(-8) and 10(-7) M concentrations of ouabain (control 8.6 +/- 0.4, AII [10(-9) M] 13.9 +/- 0.7, AII + Ouabain [5 x 10(-8) M] 10.9 +/- 0.6, AII + ouabain [10(-7) M] 7.8 +/- 0.3 ng/10(6) cells/h, both p < 0.01 vs. AII). Magnesium 5-9 NLR family pyrin domain containing 3 Homo sapiens 109-112 9513926-5 1997 High Mg++ buffer had this effect at both 10(-8) and 10(-7) M concentrations of ouabain (control 8.6 +/- 0.4, AII [10(-9) M] 13.9 +/- 0.7, AII + Ouabain [5 x 10(-8) M] 10.9 +/- 0.6, AII + ouabain [10(-7) M] 7.8 +/- 0.3 ng/10(6) cells/h, both p < 0.01 vs. AII). Magnesium 5-9 NLR family pyrin domain containing 3 Homo sapiens 138-141 9513926-5 1997 High Mg++ buffer had this effect at both 10(-8) and 10(-7) M concentrations of ouabain (control 8.6 +/- 0.4, AII [10(-9) M] 13.9 +/- 0.7, AII + Ouabain [5 x 10(-8) M] 10.9 +/- 0.6, AII + ouabain [10(-7) M] 7.8 +/- 0.3 ng/10(6) cells/h, both p < 0.01 vs. AII). Magnesium 5-9 NLR family pyrin domain containing 3 Homo sapiens 138-141 9513926-5 1997 High Mg++ buffer had this effect at both 10(-8) and 10(-7) M concentrations of ouabain (control 8.6 +/- 0.4, AII [10(-9) M] 13.9 +/- 0.7, AII + Ouabain [5 x 10(-8) M] 10.9 +/- 0.6, AII + ouabain [10(-7) M] 7.8 +/- 0.3 ng/10(6) cells/h, both p < 0.01 vs. AII). Magnesium 5-9 NLR family pyrin domain containing 3 Homo sapiens 138-141 9513926-6 1997 In contrast, a low Mg++ buffer stimulated both basal (6.9 +/- 0.2 vs. 8.3 +/- 0.4 ng/10(6) cells/h, p < 0.01) and AII stimulation of aldosterone secretion (8.4 +/- 0.2 vs. 9.8 +/- 0.4 ng/10(6) cells/h, p < 0.01). Magnesium 19-23 NLR family pyrin domain containing 3 Homo sapiens 117-120 9513926-7 1997 When ouabain was added to low Mg++ buffer there was further inhibition of AII induced aldosterone secretion than with normal Mg++ buffer. Magnesium 30-34 NLR family pyrin domain containing 3 Homo sapiens 74-77 9513926-9 1997 We conclude that ouabain actions and the effect of angiotensin II on aldosterone is inhibited by an increased level of Mg++ while low levels of Mg++ are stimulatory to both basal and AII action on aldosterone. Magnesium 119-123 angiotensinogen Homo sapiens 51-65 9513926-9 1997 We conclude that ouabain actions and the effect of angiotensin II on aldosterone is inhibited by an increased level of Mg++ while low levels of Mg++ are stimulatory to both basal and AII action on aldosterone. Magnesium 144-148 NLR family pyrin domain containing 3 Homo sapiens 183-186 9477656-7 1997 There is a quadratic relation between the serum magnesium level and the number of CD4 lymphocytes in HIV-AIDS patients studied. Magnesium 48-57 CD4 molecule Homo sapiens 82-85 9403322-4 1997 Insulin sensitivity can be improved by non-pharmacological means, essentially reduction of excessive body weight, promotion of regular physical activity and modification of dietary habits, as well as, possibly, cessation of smoking and correction of subclinical magnesium deficiency. Magnesium 262-271 insulin Homo sapiens 0-7 9368656-9 1997 On the other hand, millimolar concentrations of magnesium stabilize GroES, presumably by specific binding. Magnesium 48-57 heat shock protein family E (Hsp10) member 1 Homo sapiens 68-73 9322186-9 1997 Ingestion of sugars, fats, and sodium have been linked to decreased insulin sensitivity, while caloric restriction, exercise, ingestion of chromium, vanadium, soluble fibers, magnesium, and certain antioxidants are associated with greater insulin sensitivity. Magnesium 175-184 insulin Homo sapiens 239-246 9891124-10 1997 The stepwise regression procedure indicated that lead had negative, and calcium and magnesium positive, effects on serum CaM activity. Magnesium 84-93 calmodulin 1 Homo sapiens 121-124 9326936-6 1997 Patients who harbour CLCNKB mutations are characterized by hypokalaemic alkalosis with salt-wasting, low blood pressure, normal magnesium and hyper- or normocalciuria; they define a distinct subset of patients with Bartter"s syndrome in whom nephrocalcinosis is absent. Magnesium 128-137 chloride voltage-gated channel Kb Homo sapiens 21-27 9145932-4 1997 MGL mice also exhibited significantly lower plasma, kidney, and skull bone magnesium contents and higher urinary magnesium excretion and total brain weights. Magnesium 75-84 C-type lectin domain family 10, member A Mus musculus 0-3 9357955-0 1997 Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation. Magnesium 75-84 transketolase Homo sapiens 23-36 9357955-1 1997 Active human transketolase is a homodimeric enzyme possessing two active sites, each with a non-covalently bound thiamine diphosphate and magnesium. Magnesium 138-147 transketolase Homo sapiens 13-26 9357955-6 1997 In support of this interpretation, binding of cofactor by wild type apo-transketolase required the presence of magnesium. Magnesium 111-120 transketolase Homo sapiens 72-85 9357955-7 1997 Additionally, monomeric apo-his-transketolase required both magnesium and cofactor binding for dimer formation. Magnesium 60-69 transketolase Homo sapiens 32-45 9342541-3 1997 Insulin-resistant states, such as essential hypertension and NIDDM, as well as "normal" ageing, are characterised by similar intracellular ionic defects, i.e. accumulation of cytosolic free calcium and depletion of free magnesium. Magnesium 220-229 insulin Homo sapiens 0-7 9342541-5 1997 A rise in cellular free calcium and a depletion in cellular magnesium may induce cellular insulin resistance and vasoconstriction. Magnesium 60-69 insulin Homo sapiens 90-97 9316879-3 1997 We found that chronic proteasome inhibition using MG-341 significantly attenuated the peptidoglycan/polysaccharide (PG/PS)-induced up-regulation of iNOS in the colon and spleen and the consequent increase in plasma levels of nitrate and nitrite. Magnesium 50-52 nitric oxide synthase 2 Homo sapiens 148-152 9316879-5 1997 We also found that MG-341 attenuated PG/PS-induced increases in macroscopic colonic inflammation, bowel wall thickness, colonic dry weight and colonic MPO activity. Magnesium 19-21 myeloperoxidase Homo sapiens 151-154 9404425-1 1997 To ascertain the claimed links between peripheral insulin resistance and intracellular magnesium and calcium concentrations, we measured free intralymphocyte magnesium (Mg(i)) and calcium (Ca(i)) concentrations, as well as the rate constant of plasma glucose disappearance (K(itt)) after insulin injection (insulin tolerance test: ITT), in a group of 15 normotensive control subjects (NC) and 29 essential hypertensive subjects (EH). Magnesium 87-96 insulin Homo sapiens 50-57 9449035-6 1997 Specific micronutrients, such as potassium, magnesium and zinc also appear to be important for optimal IGF-I synthesis and anabolic effects in animal models. Magnesium 44-53 insulin like growth factor 1 Homo sapiens 103-108 9246208-3 1997 The ribozyme was tested in vitro and gave efficient and specific magnesium-dependent cleavage of mouse A-SAA2 mRNA into the expected fragments of 197 and 425 bases. Magnesium 65-74 serum amyloid A 2 Mus musculus 105-109 9196356-5 1997 A decreased fat intake was associated with an increased sugar intake, but also with increased nutrient densities of thiamin, niacin, folate, vitamin C, magnesium, and iron, reflecting an increased intake of fruit, vegetables, and grains. Magnesium 152-161 FAT atypical cadherin 1 Homo sapiens 12-15 9158084-5 1997 CRT was found to be predominantly in the sera of SLE patients associated with immune complexes and C1q, and only bound to the surfaces of neutrophils in the presence of low levels of calcium and magnesium. Magnesium 195-204 calreticulin Homo sapiens 0-3 9169293-5 1997 Lamotrigine reduced the frequency of occurrence of low-magnesium induced field potentials in CA1 and CA3 areas of the hippocampus slice preparation (guinea pigs) in a dose-dependent manner. Magnesium 55-64 carbonic anhydrase 1 Cavia porcellus 93-96 9169293-5 1997 Lamotrigine reduced the frequency of occurrence of low-magnesium induced field potentials in CA1 and CA3 areas of the hippocampus slice preparation (guinea pigs) in a dose-dependent manner. Magnesium 55-64 carbonic anhydrase 3 Cavia porcellus 101-104 9278524-1 1997 Basic fibroblast growth factor (bFGF) has been shown to induce neural fate in dissociated animal cap (AC) cells or in AC explants cultured in low calcium and magnesium concentrations. Magnesium 158-167 fibroblast growth factor 2 Homo sapiens 0-37 9285381-2 1997 We hypothesized that magnesium deficiency alters vitamin D metabolism by decreasing parathyroid hormone (PTH) response, resulting in decreased serum osteocalcin and decreased bone accretion. Magnesium 21-30 parathyroid hormone Homo sapiens 84-103 9285381-2 1997 We hypothesized that magnesium deficiency alters vitamin D metabolism by decreasing parathyroid hormone (PTH) response, resulting in decreased serum osteocalcin and decreased bone accretion. Magnesium 21-30 bone gamma-carboxyglutamate protein Homo sapiens 149-160 9290611-9 1997 CONCLUSION: Hypoparathyroidism and blunted renal response to parathyroid hormone suggest that magnesium depletion may contribute to their pathogenesis. Magnesium 94-103 parathyroid hormone Homo sapiens 61-80 9278926-3 1997 Peripheral insulin resistance, which usually responds to a very-low-fat diet, aerobic exercise training, and appropriate weight loss, can also treated with high-dose chromium picolinate, high-dose vitamin E, magnesium, soluble fiber, and possibly taurine; these measures appear likely to correct the diabetes-associated metabolic derangements of vascular smooth muscle, and thus lessen risk for macrovascular disease. Magnesium 208-217 insulin Homo sapiens 11-18 9224730-6 1997 Furthermore, incubation with PKA in the presence of ATP and magnesium ion results in a time-dependent decrease in Csk kinase activity. Magnesium 60-69 C-terminal Src kinase Homo sapiens 114-117 9230923-4 1997 [Mg2+]m depends on both the size of the total Mg2+ pool and the ability of matrix anions to provide Mg-ligands. Magnesium 1-3 mucin 7, secreted Homo sapiens 46-49 9368910-10 1997 Magnesium infusion was associated with a significant elevation in ADP (+19.3%); ristocetin (+13.6%); and collagen-induced platelet aggregation (+14.2%); an increase in plasma antithrombin-III (+10.3%) and thromboxane (+49.4%) when compared to pre-infusion levels. Magnesium 0-9 serpin family C member 1 Homo sapiens 175-191 9195931-3 1997 In this study, we show that the magnesium-dependent, neutral pH-optimum and membrane-associated sphingomyelinase (N-SMase) is inhibited, in a dose-dependent manner, by glutathione (GSH) at physiological concentrations with a greater than 95% inhibition observed at 5 mM GSH. Magnesium 32-41 sphingomyelin phosphodiesterase 2 Homo sapiens 114-121 9215634-0 1997 Regulation of IRK3 inward rectifier K+ channel by m1 acetylcholine receptor and intracellular magnesium. Magnesium 94-103 potassium inwardly rectifying channel subfamily J member 4 Homo sapiens 14-18 9165035-11 1997 A balance study performed during the last 3 days of the experiment revealed that PTH increased apparent intestinal magnesium absorption in the +D group only. Magnesium 115-124 parathyroid hormone Rattus norvegicus 81-84 9165035-14 1997 Furthermore, PTH may have a vitamin D-dependent influence on intestinal magnesium absorption. Magnesium 72-81 parathyroid hormone Rattus norvegicus 13-16 9206991-0 1997 Elevation of extracellular magnesium rapidly raises intracellular free Mg2+ in human aortic endothelial cells: is extracellular Mg2+ a regulatory cation? Magnesium 27-36 mucin 7, secreted Homo sapiens 71-74 9206991-1 1997 Extracellular magnesium ions [Mg2+]o are known to regulate functions of endothelial cells, but whether [Mg2+]o can alter intracellular free ionized magnesium [Mg2+]i in these cells remains unknown. Magnesium 14-23 mucin 7, secreted Homo sapiens 30-33 9206991-1 1997 Extracellular magnesium ions [Mg2+]o are known to regulate functions of endothelial cells, but whether [Mg2+]o can alter intracellular free ionized magnesium [Mg2+]i in these cells remains unknown. Magnesium 148-157 mucin 7, secreted Homo sapiens 104-107 9206991-1 1997 Extracellular magnesium ions [Mg2+]o are known to regulate functions of endothelial cells, but whether [Mg2+]o can alter intracellular free ionized magnesium [Mg2+]i in these cells remains unknown. Magnesium 148-157 mucin 7, secreted Homo sapiens 104-107 9333591-1 1997 Clinical electrophysiological effects of magnesium (Mg2+) are known for more than 60 years. Magnesium 41-50 mucin 7, secreted Homo sapiens 52-55 9177378-6 1997 Furthermore, a blunting of Mg(i) responses to insulin could be reproduced in normal cells that were magnesium depleted by prior treatment either with A23187 in a calcium-free medium or with high glucose concentrations (15 mmol/L). Magnesium 100-109 insulin Homo sapiens 46-53 9201698-0 1997 Effect of cations on the tyrosine kinase activity of the insulin receptor: inhibition by fluoride is magnesium dependent. Magnesium 101-110 insulin receptor Rattus norvegicus 57-73 9194174-1 1997 The three-dimensional structures of the magnesium- and manganese-bound forms of calbindin D9k were determined to 1.6 A and 1.9 A resolution, respectively, using X-ray crystallography. Magnesium 40-49 S100 calcium binding protein G Homo sapiens 80-93 9249893-2 1997 The observation that some subjects with low PTH had elevated plasma magnesium (Mg) levels prompted us to analyze in 41 patients on maintenance hemodialysis for 44 +/- 36 months, their serum Mg concentrations, and the relationship between plasma Mg and PTH levels. Magnesium 68-77 parathyroid hormone Homo sapiens 44-47 9249893-2 1997 The observation that some subjects with low PTH had elevated plasma magnesium (Mg) levels prompted us to analyze in 41 patients on maintenance hemodialysis for 44 +/- 36 months, their serum Mg concentrations, and the relationship between plasma Mg and PTH levels. Magnesium 79-81 parathyroid hormone Homo sapiens 44-47 9249893-9 1997 Interestingly, patients with low PTH had a significantly higher serum Mg concentration than patients with adequate or high PTH (2.8 +/- 0.2 mg/dl vs 2.3 +/- 0.1 mg/dl and 2.2 +/- 0.1 mg/dl, respectively, p < 0.01). Magnesium 70-72 parathyroid hormone Homo sapiens 33-36 9153200-7 1997 Investigation of other divalent cations (copper and magnesium) indicated that augmentation of heparin binding by HRG in the presence of antithrombin was restricted to zinc. Magnesium 52-61 histidine rich glycoprotein Homo sapiens 113-116 9145932-4 1997 MGL mice also exhibited significantly lower plasma, kidney, and skull bone magnesium contents and higher urinary magnesium excretion and total brain weights. Magnesium 113-122 C-type lectin domain family 10, member A Mus musculus 0-3 9092668-4 1997 At physiologic concentrations of magnesium, Cbp2 stimulates the splicing of the ribosomal RNA intron in vitro . Magnesium 33-42 Cbp2p Saccharomyces cerevisiae S288C 44-48 9092668-7 1997 This intron does need Cbp2 for catalytic activity in physiologic magnesium. Magnesium 65-74 Cbp2p Saccharomyces cerevisiae S288C 22-26 9196855-9 1997 High magnesium attenuated vasopressin- and norepinephrine-induced vasoconstriction in SHR (p < 0.01), whereas high magnesium attenuated only norepinephrine-induced vasoconstriction in WKY (p < 0.001). Magnesium 5-14 arginine vasopressin Rattus norvegicus 26-37 9130780-11 1997 If these changes in messenger RNA are translated into increased NR2B and decreased NR2D subunits in the N-methyl-D-aspartate receptors in vivo, both a decrease in sensitivity due to a strong magnesium block and an increase in channel ion gating might be predicted. Magnesium 191-200 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 64-68 9130780-11 1997 If these changes in messenger RNA are translated into increased NR2B and decreased NR2D subunits in the N-methyl-D-aspartate receptors in vivo, both a decrease in sensitivity due to a strong magnesium block and an increase in channel ion gating might be predicted. Magnesium 191-200 glutamate ionotropic receptor NMDA type subunit 2D Rattus norvegicus 83-87 9106453-4 1997 In contrast, the present experiments demonstrated that in calcium-free solution (magnesium replacement) zinc can potentiate both GluR3, as expected, but also GluR1. Magnesium 81-90 glutamate receptor, ionotropic, AMPA 3 L homeolog Xenopus laevis 129-134 9106453-4 1997 In contrast, the present experiments demonstrated that in calcium-free solution (magnesium replacement) zinc can potentiate both GluR3, as expected, but also GluR1. Magnesium 81-90 glutamate receptor, ionotropic, AMPA 1 L homeolog Xenopus laevis 158-163 9056694-8 1997 By contrast, in NIDDM patients daily magnesium administration, restoring a more appropriate intracellular magnesium concentration, contributes to improve insulin-mediated glucose uptake. Magnesium 106-115 insulin Homo sapiens 154-161 9056482-12 1997 Calretinin appears to bind 4.69 +/- 0.13 magnesium ions with Kd = 4.5 mM. Magnesium 41-50 calbindin 2 Gallus gallus 0-10 9047313-5 1997 (3) The free magnesium ion activates Csk and Src kinase activity by increasing the Vmax but does not change their apparent Km(ATP-Mg). Magnesium 13-22 C-terminal Src kinase Homo sapiens 37-40 9047313-5 1997 (3) The free magnesium ion activates Csk and Src kinase activity by increasing the Vmax but does not change their apparent Km(ATP-Mg). Magnesium 13-22 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 45-48 9037321-7 1997 The reduction in serum ACE activity correlated to a more pronounced increase in S-Mg r = -0.62, P < .002), and decrease in the Ca/Mg ratio (r = 0.73, P = .0002). Magnesium 82-84 angiotensin I converting enzyme Homo sapiens 23-26 9037321-8 1997 We conclude that the changes in the studied metabolic variables and serum ACE activity during ACE inhibitor treatment are related to alterations in mineral status and the balance between calcium and magnesium concentrations in serum. Magnesium 199-208 angiotensin I converting enzyme Homo sapiens 74-77 9037321-8 1997 We conclude that the changes in the studied metabolic variables and serum ACE activity during ACE inhibitor treatment are related to alterations in mineral status and the balance between calcium and magnesium concentrations in serum. Magnesium 199-208 angiotensin I converting enzyme Homo sapiens 94-97 9102461-7 1997 The annealing activity of p53 is almost abolished in the presence of magnesium indicating that it can be sharply regulated in vitro and, in principle, could also be regulated in vivo. Magnesium 69-78 tumor protein p53 Homo sapiens 26-29 9056694-4 1997 In fact, in vitro and in vivo studies have demonstrated that insulin may modulate the shift of magnesium from extracellular to intracellular space. Magnesium 95-104 insulin Homo sapiens 61-68 9056694-5 1997 Intracellular magnesium concentration has also been shown to be effective on modulating insulin action (mainly oxidative glucose metabolism), offset calcium-related excitation-contraction coupling, and decrease smooth cell responsiveness to depolarizing stimuli, by stimulating Ca2+-dependent K+ channels. Magnesium 14-23 insulin Homo sapiens 88-95 9056694-6 1997 A poor intracellular magnesium concentration, as found in non-insulin-dependent diabetes mellitus (NIDDM) and in hypertensive (HP) patients, may result in a defective tyrosine-kinase activity at the insulin receptor level and exaggerated intracellular calcium concentration. Magnesium 21-30 insulin receptor Homo sapiens 199-215 9056694-8 1997 By contrast, in NIDDM patients daily magnesium administration, restoring a more appropriate intracellular magnesium concentration, contributes to improve insulin-mediated glucose uptake. Magnesium 37-46 insulin Homo sapiens 154-161 9073168-6 1997 In vitro expression studies have shown that the NR1-NR2C subunit combination exhibits weaker magnesium block and higher affinity for glycine than NR1-NR2B. Magnesium 93-102 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 48-51 9073168-6 1997 In vitro expression studies have shown that the NR1-NR2C subunit combination exhibits weaker magnesium block and higher affinity for glycine than NR1-NR2B. Magnesium 93-102 glutamate receptor, ionotropic, NMDA2C (epsilon 3) Mus musculus 52-56 9038151-5 1997 When compared with the rat P2X7 receptor, these effects required higher concentrations of agonists, were more potentiated by removal of extracellular magnesium ions, and reversed more rapidly on agonist removal. Magnesium 150-159 purinergic receptor P2X 7 Homo sapiens 27-31 9048573-11 1997 Steady-state kinetic analyses of Csk reactions with Co and Ni in addition to Mg and Mn on wild-type and D314E Csk with ATP and ATP gamma S [adenosine 5"-O-(3-thiotriphosphate)] as substrates were performed. Magnesium 77-79 C-terminal Src kinase Homo sapiens 110-113 9054975-3 1997 To facilitate the analysis of the CCE1-junction interaction, we have exploited the sequence dependence of the cleavage reaction to devise a junction that is refractory to cleavage by this enzyme, even in the presence of magnesium ions. Magnesium 220-229 cruciform cutting endonuclease Saccharomyces cerevisiae S288C 34-38 9054975-5 1997 The structure of the CCE1-junction complex is independent of the sequence of the junction, and of the presence or absence of magnesium or other ions. Magnesium 125-134 cruciform cutting endonuclease Saccharomyces cerevisiae S288C 21-25 9056694-9 1997 Similarly, in HP patients magnesium administration may be useful in decreasing arterial blood pressure and improving insulin-mediated glucose uptake. Magnesium 26-35 insulin Homo sapiens 117-124 9056694-11 1997 In conclusion, a growing body of studies suggest that intracellular magnesium may play a key role on modulating insulin-mediated glucose uptake and vascular tone. Magnesium 68-77 insulin Homo sapiens 112-119 9040025-0 1997 Magnesium-deficiency-enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade. Magnesium 0-9 tachykinin receptor 1 Rattus norvegicus 76-96 8988947-7 1997 Dietary starch was directly related to SBP and DBP; dietary saturated fatty acid and cholesterol and Keys score were directly related to DBP; dietary magnesium, fiber, and caffeine were inversely related to SBP and DBP; and dietary protein, polyunsaturated fatty acids, the ratio of polyunsaturated to saturated fatty acid, and other simple carbohydrates were inversely related to DBP. Magnesium 150-159 selenium binding protein 1 Homo sapiens 207-210 9058369-4 1997 In addition calcitonin, particularly at 0.1 and 1.0 mg concentrations, increased absolute Ca and Mg reabsorption. Magnesium 97-99 calcitonin related polypeptide alpha Homo sapiens 12-22 9041517-3 1997 The overall structure of TRAP is conserved in all species; specifically, an amino-terminal A-domain similar to magnesium-binding domains of mammalian integrins; a thrombospondin-like sulfatide-binding domain similar to region II in Plasmodium circumsporozoite protein; an acidic asparagine/proline-rich repeat region; a trans-membrane domain and a short acidic cytoplasmic region with a highly conserved carboxy terminus. Magnesium 111-120 TRAP Homo sapiens 25-29 9058369-7 1997 It is concluded that in man calcitonin like PTH is a renal Ca- and Mg-conserving hormone. Magnesium 67-69 calcitonin related polypeptide alpha Homo sapiens 28-38 9058369-7 1997 It is concluded that in man calcitonin like PTH is a renal Ca- and Mg-conserving hormone. Magnesium 67-69 parathyroid hormone Homo sapiens 44-47 9096270-12 1997 To the contrary, tap water produced an unfavourable change in the magnesium excretion. Magnesium 66-75 nuclear RNA export factor 1 Homo sapiens 17-20 9501684-6 1997 Magnesium has been forgotten cation from the therapeutical point of view, but now several clinical reports point to the salutary actions of Mg+2 in various lung diseases. Magnesium 0-9 mucin 7, secreted Homo sapiens 140-144 8968545-8 1996 A high extracellular magnesium concentration (4.8 mM) attenuated endothelin-1-induced contractions in tissues from DOCA-salt hypertensive rats but not in tissues from normotensive rats. Magnesium 21-30 endothelin 1 Rattus norvegicus 65-77 9596863-1 1997 OBJECTIVE: To evaluate the magnesium and calcium concentration of peripheral serum and mononuclear in patients with pregnancy induced hypertension (PIH). Magnesium 27-36 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 148-151 9596863-5 1997 CONCLUSION: The decrease of magnesium and calcium concentration may be one of the important factors responsible for the pathophysiologic changes of PIH. Magnesium 28-37 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 148-151 8969236-12 1996 Physiological concentrations of calcium and magnesium specifically increase the apparent rate of PDI-dependent aggregation and shift the chaperone activity to higher PDI concentrations. Magnesium 44-53 prolyl 4-hydroxylase subunit beta Homo sapiens 97-100 8969236-12 1996 Physiological concentrations of calcium and magnesium specifically increase the apparent rate of PDI-dependent aggregation and shift the chaperone activity to higher PDI concentrations. Magnesium 44-53 prolyl 4-hydroxylase subunit beta Homo sapiens 166-169 8973542-1 1996 Tobacco peroxidase (36 kDa, pI 3.5) exhibits unique catalytic and spectral properties that are modulated by pH, calcium and magnesium ions. Magnesium 124-133 lignin-forming anionic peroxidase-like Nicotiana tabacum 8-18 8973542-4 1996 The enhancement of tobacco peroxidase activity by magnesium ions is to our knowledge the first example of a magnesium-induced peroxidase activation. Magnesium 50-59 lignin-forming anionic peroxidase-like Nicotiana tabacum 27-37 8973542-4 1996 The enhancement of tobacco peroxidase activity by magnesium ions is to our knowledge the first example of a magnesium-induced peroxidase activation. Magnesium 50-59 lignin-forming anionic peroxidase-like Nicotiana tabacum 126-136 8973542-4 1996 The enhancement of tobacco peroxidase activity by magnesium ions is to our knowledge the first example of a magnesium-induced peroxidase activation. Magnesium 108-117 lignin-forming anionic peroxidase-like Nicotiana tabacum 27-37 8973542-4 1996 The enhancement of tobacco peroxidase activity by magnesium ions is to our knowledge the first example of a magnesium-induced peroxidase activation. Magnesium 108-117 lignin-forming anionic peroxidase-like Nicotiana tabacum 126-136 8973542-5 1996 UV/visible spectra of tobacco peroxidase showed that the Soret band shifted and its absorption coefficient increased upon the addition of calcium or magnesium ions and on lowering the pH. Magnesium 149-158 lignin-forming anionic peroxidase-like Nicotiana tabacum 30-40 8968545-0 1996 Endothelin-1-induced contraction in isolated aortae from normotensive and DOCA-salt hypertensive rats: effect of magnesium. Magnesium 113-122 endothelin 1 Rattus norvegicus 0-12 8968545-9 1996 In the absence of calcium, a high concentration of magnesium attenuated endothelin-1-induced contraction in aortae from both normotensive and hypertensive rats. Magnesium 51-60 endothelin 1 Rattus norvegicus 72-84 8968545-12 1996 Absence of magnesium attenuated endothelin-1-induced contractions in aortae from both normotensive and DOCA-salt hypertensive rats. Magnesium 11-20 endothelin 1 Rattus norvegicus 32-44 8968545-13 1996 In the absence of calcium, removal of magnesium totally inhibited endothelin-1-induced contraction in tissues from normotensive rats but had no effect in those from hypertensive rats. Magnesium 38-47 endothelin 1 Rattus norvegicus 66-78 8968545-14 1996 In the presence of ryanodine, the lack of magnesium inhibited endothelin-1-induced contractions in aortae from DOCA-salt hypertensive rats but increased the sensitivity to endothelin-1 of aortae from normotensive rats. Magnesium 42-51 endothelin 1 Rattus norvegicus 62-74 8968545-14 1996 In the presence of ryanodine, the lack of magnesium inhibited endothelin-1-induced contractions in aortae from DOCA-salt hypertensive rats but increased the sensitivity to endothelin-1 of aortae from normotensive rats. Magnesium 42-51 endothelin 1 Rattus norvegicus 172-184 8968545-17 1996 Conversely, the attenuating effect of magnesium removal on endothelin-1-induced contractions did not occur when endothelium was present. Magnesium 38-47 endothelin 1 Rattus norvegicus 59-71 8968545-21 1996 Changes in extracellular magnesium concentration differentially alter endothelin-1-induced contraction in aortae from normotensive and hypertensive rats, possibly by interfering with calcium utilization during contraction. Magnesium 25-34 endothelin 1 Rattus norvegicus 70-82 8968545-22 1996 Magnesium may be required for the contractile response to endothelin-1 and increasing magnesium may limit the vascular effects of endothelin-1 in blood vessels from DOCA-salt hypertensive rats. Magnesium 0-9 endothelin 1 Rattus norvegicus 58-70 8968545-22 1996 Magnesium may be required for the contractile response to endothelin-1 and increasing magnesium may limit the vascular effects of endothelin-1 in blood vessels from DOCA-salt hypertensive rats. Magnesium 86-95 endothelin 1 Rattus norvegicus 130-142 8968747-8 1996 FBN1-RZ1 cleavage is magnesium dependent and efficient at both 37 and 50 degrees C. Delivery of the FBN1-RZ1 ribozyme into cultured dermal fibroblasts, by receptor-mediated endocytosis of a ribozyme-transferrin-polylysine complex, specifically reduces both cellular FBN1 mRNA and the deposition of fibrillin in the extracellular matrix. Magnesium 21-30 fibrillin 1 Homo sapiens 0-4 8940379-14 1996 The effects on this AC of nucleotides, Ca++, and Mg++ at concentrations prevailing in the hypothyroid brown adipocyte are probably the major factor in the reduced capacity of these cells to generate cAMP. Magnesium 49-53 adenylate cyclase 6 Rattus norvegicus 20-22 8968747-8 1996 FBN1-RZ1 cleavage is magnesium dependent and efficient at both 37 and 50 degrees C. Delivery of the FBN1-RZ1 ribozyme into cultured dermal fibroblasts, by receptor-mediated endocytosis of a ribozyme-transferrin-polylysine complex, specifically reduces both cellular FBN1 mRNA and the deposition of fibrillin in the extracellular matrix. Magnesium 21-30 fibrillin 1 Homo sapiens 100-104 8968747-8 1996 FBN1-RZ1 cleavage is magnesium dependent and efficient at both 37 and 50 degrees C. Delivery of the FBN1-RZ1 ribozyme into cultured dermal fibroblasts, by receptor-mediated endocytosis of a ribozyme-transferrin-polylysine complex, specifically reduces both cellular FBN1 mRNA and the deposition of fibrillin in the extracellular matrix. Magnesium 21-30 fibrillin 1 Homo sapiens 100-104 8943500-0 1996 Extracellular calcium-sensing receptor: implications for calcium and magnesium handling in the kidney. Magnesium 69-78 calcium sensing receptor Homo sapiens 0-38 8939907-4 1996 This 5-ptase is magnesium-dependent and removes the 5-position phosphate from PtdIns-3,4,5-P3 but does not metabolize PtdIns-4,5-P2, inositol (Ins)-1,3,4,5-P4, or Ins-1,4,5-P3. Magnesium 16-25 inositol polyphosphate-5-phosphatase A Homo sapiens 5-12 8920934-5 1996 In magnesium-limited medium, the cell growth of a spermine-sensitive polyamine uptake mutant transformed with PTK2 recovered its sensitivity to spermine. Magnesium 3-12 protein kinase PTK2 Saccharomyces cerevisiae S288C 110-114 8913585-7 1996 The CFTR protein contains clusters of negatively charged amino acids on several extracellular loops joining the transmembrane segments, which could constitute the putative binding sites for Ca and Mg. Magnesium 197-199 CF transmembrane conductance regulator Homo sapiens 4-8 8875927-2 1996 Splicing of the AT-AC intron 2 of a sodium channel (SCN4A) precursor messenger RNA in vitro did not require inhibition of conventional splicing and required adenosine triphosphate, magnesium, and U12 small nuclear RNA (snRNA). Magnesium 181-190 sodium voltage-gated channel alpha subunit 4 Homo sapiens 52-57 9275364-10 1996 ET-1 secretion may be indirectly influenced by magnesium in PIH. Magnesium 47-56 endothelin 1 Homo sapiens 0-4 9275364-10 1996 ET-1 secretion may be indirectly influenced by magnesium in PIH. Magnesium 47-56 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 60-63 8903341-2 1996 Randomization mutagenesis of the analogous sequence in the Saccharomyces cerevisiae nuclear RNase P RNA gene, RPR1, gave viable sequence variants that confer magnesium-correctable growth defects and are defective in magnesium cofactor utilization by the RNase P holoenzyme in vitro. Magnesium 216-225 RPR1 Saccharomyces cerevisiae S288C 110-114 8903341-2 1996 Randomization mutagenesis of the analogous sequence in the Saccharomyces cerevisiae nuclear RNase P RNA gene, RPR1, gave viable sequence variants that confer magnesium-correctable growth defects and are defective in magnesium cofactor utilization by the RNase P holoenzyme in vitro. Magnesium 158-167 RPR1 Saccharomyces cerevisiae S288C 110-114 8798689-0 1996 Angiotensin II and vasopressin modulate intracellular free magnesium in vascular smooth muscle cells through Na+-dependent protein kinase C pathways. Magnesium 59-68 angiotensinogen Rattus norvegicus 0-14 8798689-0 1996 Angiotensin II and vasopressin modulate intracellular free magnesium in vascular smooth muscle cells through Na+-dependent protein kinase C pathways. Magnesium 59-68 arginine vasopressin Rattus norvegicus 19-30 8981248-17 1996 In Mg-deficient rats, the degree of translocation of GLUT4 to plasma membranes in the adipocytes stimulated by insulin was reduced only at eight weeks. Magnesium 3-5 solute carrier family 2 member 4 Rattus norvegicus 53-58 8914428-4 1996 Several mechanisms mediated by hyperinsulinemia can be entertained as follows: 1) sodium and water retention, 2) increased sympathetic nerve activity and reduced catecholamine clearance, 3) increased intracellular calcium concentration and reduced magnesium concentration, 4) increased coagulant activity and impaired fibrinolytic activity, 5) impaired endothelium-dependent NO synthesis and release, 6) increased vascular responsiveness for the vasoactive substrates, 7) increased proliferation of vascular smooth muscle cell by activation of protein kinase C or mediated by insulin and IGF-1 action. Magnesium 248-257 insulin Homo sapiens 36-43 8798586-4 1996 Membrane extracts prepared from cells expressing DG42 encoded on a plasmid incorporated [14C]glucuronic acid and N-[3H]acetylglucosamine from exogenously supplied UDP-sugar nucleotides into a high molecular mass (10(6) to 10(7) Da) polymer in the presence of magnesium ions. Magnesium 259-268 hyaluronan synthase 1 S homeolog Xenopus laevis 49-53 8856104-1 1996 The phosphorylation of the sarcoplasmic reticulum Ca-ATPase (EC 3.6.1.38) with P(i) was characterized using Mn as a Mg analogue. Magnesium 116-118 dynein axonemal heavy chain 8 Homo sapiens 53-59 8783675-6 1996 In the kidney, the CaR directly inhibits tubular reabsorption of calcium and magnesium in the thick ascending limb, and may be responsible for the long-recognized, but poorly understood inhibition of urinary concentrating ability by hypercalcemia. Magnesium 77-86 CXADR pseudogene 1 Homo sapiens 19-22 8999005-5 1996 The function of major platelet membrane receptors, such as the fibrinogen receptor GP-IIb-IIIa and P-selectin are also inhibited by extracellular magnesium. Magnesium 146-155 selectin P Homo sapiens 99-109 8824590-6 1996 We demonstrate that FEM-2 exhibits magnesium-dependent casein phosphatase activity, typical of PP2C, in vitro. Magnesium 35-44 Protein phosphatase fem-2 Caenorhabditis elegans 20-25 8800040-6 1996 Typical therapy for heart failure (digoxin, diuretic agents, and ACE inhibitors) are influenced by or associated with significant alteration in magnesium balance. Magnesium 144-153 angiotensin I converting enzyme Homo sapiens 65-68 8694904-0 1996 Calcium and magnesium: low passive permeability and tubular secretion in the mouse medullary thick ascending limb of Henle"s loop (MTAL). Magnesium 12-21 talipes Mus musculus 131-135 8909693-1 1996 Being cofactors of important antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), which are significantly modified in Down"s syndrome (trisomy 21), serum levels of microtrace elements zinc, copper, and selenium and of macroelement magnesium are reported in 16 subjects with Down"s syndrome (DS) and their respective well age- and sex-matched controls. Magnesium 259-268 superoxide dismutase 1 Homo sapiens 49-69 8909693-1 1996 Being cofactors of important antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), which are significantly modified in Down"s syndrome (trisomy 21), serum levels of microtrace elements zinc, copper, and selenium and of macroelement magnesium are reported in 16 subjects with Down"s syndrome (DS) and their respective well age- and sex-matched controls. Magnesium 259-268 superoxide dismutase 1 Homo sapiens 71-74 8841762-5 1996 PCBs, in general, play a minor role in the contamination of the fjord by the magnesium production process, except for the highly chlorinated congeners such as PCB-209. Magnesium 77-86 pyruvate carboxylase Homo sapiens 0-3 8752121-7 1996 Serotonin-induced, magnesium-dependent reduction in PTX-mediated ADP-ribosylation of G alpha i/G alpha o in cortical membranes from bipolar brains was greater than that observed in controls, providing further evidence for enhanced receptor-G protein coupling in bipolar brain membranes. Magnesium 19-28 G protein subunit alpha o1 Homo sapiens 95-104 8702787-0 1996 Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions. Magnesium 62-71 RAB5A, member RAS oncogene family Homo sapiens 27-31 8702787-0 1996 Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions. Magnesium 62-71 RAB7B, member RAS oncogene family Homo sapiens 36-40 8702748-2 1996 This lectin agglutinated trypsinized and glutaraldehyde-fixed bovine red blood cells in the presence of calcium or magnesium. Magnesium 115-124 Galactose-specific C-type lectin Drosophila melanogaster 5-11 8805579-4 1996 In addition to the different bound cation, a "ligand mimetic" crystal lattice interaction in the CD11b I domain structure with bound magnesium has led to the interpretation that the different CD11b I domain structures represent different affinity states of I domains. Magnesium 133-142 integrin subunit alpha M Homo sapiens 97-102 8805579-4 1996 In addition to the different bound cation, a "ligand mimetic" crystal lattice interaction in the CD11b I domain structure with bound magnesium has led to the interpretation that the different CD11b I domain structures represent different affinity states of I domains. Magnesium 133-142 integrin subunit alpha M Homo sapiens 192-197 8805579-8 1996 RESULTS: We report here the crystal structures of the CD11a I domain determined in the absence of bound metal ion and with bound magnesium ion. Magnesium 129-138 integrin subunit alpha L Homo sapiens 54-59 8805579-10 1996 The structures of the CD11a I domain with magnesium or manganese bound are extremely similar. Magnesium 42-51 integrin subunit alpha L Homo sapiens 22-27 8806704-1 1996 The fluorescent probe furaptra shows increases and decreases in the concentration of free magnesium ion, [Mg2+], in the mitochondrial matrix with changes in total Mg2+ and ligand availability. Magnesium 90-99 mucin 7, secreted Homo sapiens 106-109 8864483-2 1996 Low extracellular Mg ([Mg2+]o) (0.3 mM) significantly increased [Ca2+]i compared to 1.2 and 4.8 mM [Mg2+]o. Magnesium 18-20 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 65-68 8645720-1 1996 Magnesium ion is an allosteric effector of 5"-nucleotidase and thus activates adenosine production from AMP. Magnesium 0-9 5'-nucleotidase ecto Homo sapiens 43-58 8645720-7 1996 Cytosolic free magnesium, as estimated by 31P-NMR after 15 min of perfusion with 6 mM Mg2+ or from chemically measured indicator metabolites after 30 min, rose 60 and 144% respectively (P < 0.05). Magnesium 15-24 mucin 7, secreted Homo sapiens 86-89 8645720-15 1996 A simplified model of compartmentalized adenosine metabolism is proposed in which magnesium ion-activated cardiac purine release originates predominantly from the ecto 5"-nucleotidase; magnesium ion stimulation of metabolic flux through the cytosolic isoforms was constrained by concomitant reductions in intracellular AMP substrate and allosteric activator ADP. Magnesium 82-91 5'-nucleotidase ecto Homo sapiens 163-183 8736554-7 1996 The magnesium ion is absent in EF-G-GDP. Magnesium 4-13 G elongation factor mitochondrial 1 Homo sapiens 31-35 8645720-16 1996 Magnesium ion-enhanced adenosine formation by 5"-nucleotidase could contribute to the known cardioprotective effects of this clinically used cation. Magnesium 0-9 5'-nucleotidase ecto Homo sapiens 46-61 8674533-3 1996 Second, an authentic member of the 14-3-3 family, recombinant Arabidopsis GF14omega, caused inactivation of phospho-NR in a magnesium-dependent manner identical to IP. Magnesium 124-133 general regulatory factor 2 Arabidopsis thaliana 74-83 8760660-6 1996 The prevention of the secondary effects of diuretics and ACE inhibitors on renal function, serum sodium, potassium and magnesium concentrations, is based on an initial low dose prescription, the detection and correction of risk factors and strict clinical and biological surveillance. Magnesium 119-128 angiotensin I converting enzyme Homo sapiens 57-60 21153281-3 1996 PRL secretory granules contain zinc, calcium, and magnesium, which inhibit depolymerization and dissolution of granules. Magnesium 50-59 prolactin Rattus norvegicus 0-3 8652652-3 1996 Cardiac AMPK is also under phosphorylation control, since in vitro incubation of cardiac AMPK with protein phosphatase 2A completely abolished activity, while incubation with ATP/Mg(2+) resulted in over a 2-fold increase in activity. Magnesium 179-181 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 8-12 8799466-1 1996 ATP, complexed with magnesium and as free anion, binds to rabbit erythroblasts glucose-6-phosphate dehydrogenase (G6PD) inducing significant structural transitions in the enzyme, revealed by a different heat stability. Magnesium 20-29 glucose-6-phosphate 1-dehydrogenase Oryctolagus cuniculus 79-112 8799466-1 1996 ATP, complexed with magnesium and as free anion, binds to rabbit erythroblasts glucose-6-phosphate dehydrogenase (G6PD) inducing significant structural transitions in the enzyme, revealed by a different heat stability. Magnesium 20-29 glucose-6-phosphate 1-dehydrogenase Oryctolagus cuniculus 114-118 8773758-0 1996 Tissue manganese levels and liver pyruvate carboxylase activity in magnesium-deficient rats. Magnesium 67-76 pyruvate carboxylase Rattus norvegicus 34-54 8773758-5 1996 Dietary magnesium depletion diminished pyruvate carboxylase (EC 6.4.1.1) activity in the crude mitochondrial fraction of liver. Magnesium 8-17 pyruvate carboxylase Rattus norvegicus 39-59 9138860-0 1996 Role of free radicals and substance P in magnesium deficiency. Magnesium 41-50 tachykinin precursor 1 Homo sapiens 26-37 8720036-4 1995 (2) ANP infusion significantly increased urine flow rate (UFR), creatinine clearance (CCr), fractional excretion rates of sodium (FENa) and chloride (FECl), and urinary phosphorus and magnesium (Mg) excretions in a dose-dependent manner without affecting renal plasma flow and fractional excretion rates of potassium and urea in cisplatin-treated rats. Magnesium 184-193 natriuretic peptide A Rattus norvegicus 4-7 8685276-10 1996 Immunoblotting showed that the distribution of CHL H protein between the stroma and chloroplast membranes varies depending on the concentration of Mg+. Magnesium 147-150 magnesium-chelatase subunit chlH, chloroplast, putative / Mg-protoporphyrin IX chelatase, putative (CHLH) Arabidopsis thaliana 47-52 8708176-8 1996 TNF, either in standard Krebs" solutions (p = 0.039) or calcium-free Krebs" solution (p = 0.014), produced an increased incidence of contracture development compared to control, whereas TNF in magnesium-substituted calcium-free Krebs" solution did not. Magnesium 193-202 tumor necrosis factor Homo sapiens 186-189 8607193-2 1996 Our aim was to study the serum ionized magnesium (Me2+) evolution and establish its relation to serum total Mg and citrate levels during OLT. Magnesium 39-48 malic enzyme 2 Homo sapiens 50-53 8735829-11 1996 Following maximal stimulation with collagen in PRP, a synergistic inhibition of ASA and Mg on platelet aggregation was demonstrated. Magnesium 88-90 complement component 4 binding protein alpha Homo sapiens 47-50 8819089-0 1996 Immunoregulation by neuropeptides in magnesium deficiency: ex vivo effect of enhanced substance P production on circulating T lymphocytes from magnesium-deficient mice. Magnesium 143-152 tachykinin 1 Mus musculus 86-97 8819089-1 1996 The first week of dietary magnesium deficiency in rodent models is characterized by the induction of raised levels of neuropeptides (substance P [SP] and calcitonin gene related peptide [CGRP]), followed shortly thereafter by inflammatory cytokine release. Magnesium 26-35 tachykinin 1 Mus musculus 133-144 8819089-1 1996 The first week of dietary magnesium deficiency in rodent models is characterized by the induction of raised levels of neuropeptides (substance P [SP] and calcitonin gene related peptide [CGRP]), followed shortly thereafter by inflammatory cytokine release. Magnesium 26-35 tachykinin 1 Mus musculus 146-148 8819089-1 1996 The first week of dietary magnesium deficiency in rodent models is characterized by the induction of raised levels of neuropeptides (substance P [SP] and calcitonin gene related peptide [CGRP]), followed shortly thereafter by inflammatory cytokine release. Magnesium 26-35 calcitonin/calcitonin-related polypeptide, alpha Mus musculus 154-185 8819089-1 1996 The first week of dietary magnesium deficiency in rodent models is characterized by the induction of raised levels of neuropeptides (substance P [SP] and calcitonin gene related peptide [CGRP]), followed shortly thereafter by inflammatory cytokine release. Magnesium 26-35 calcitonin/calcitonin-related polypeptide, alpha Mus musculus 187-191 8819089-8 1996 The secretion of these cytokines was maximal at either 5 days (IL-4, IL-5) or 7 days (II-2, IL-10, and IFN-gamma) of magnesium deficiency. Magnesium 117-126 interferon gamma Mus musculus 103-112 8819089-9 1996 This increased sensitivity to SP appears to be related to an increased expression of SP receptors on the surface of T lymphocytes during the first week of magnesium deficiency. Magnesium 155-164 tachykinin 1 Mus musculus 30-32 8819089-10 1996 These data indicate that SP released early during magnesium deficiency exerts a regulatory role on T lymphocyte cytokine production, especially those cytokines regulating mast cell and immune responses leading to the onset of an immunopathological state. Magnesium 50-59 tachykinin 1 Mus musculus 25-27 8819095-10 1996 Plasma levels of the inflammatory cytokines tumour necrosis factor (TNF) and interleukin-6 (IL-6) are increased in NEC and in magnesium deficiency; these experimentally produce shock and tissue injury, especially of the intestine. Magnesium 126-135 tumor necrosis factor Homo sapiens 44-66 8819095-10 1996 Plasma levels of the inflammatory cytokines tumour necrosis factor (TNF) and interleukin-6 (IL-6) are increased in NEC and in magnesium deficiency; these experimentally produce shock and tissue injury, especially of the intestine. Magnesium 126-135 tumor necrosis factor Homo sapiens 68-71 8819095-10 1996 Plasma levels of the inflammatory cytokines tumour necrosis factor (TNF) and interleukin-6 (IL-6) are increased in NEC and in magnesium deficiency; these experimentally produce shock and tissue injury, especially of the intestine. Magnesium 126-135 interleukin 6 Homo sapiens 77-90 8819095-10 1996 Plasma levels of the inflammatory cytokines tumour necrosis factor (TNF) and interleukin-6 (IL-6) are increased in NEC and in magnesium deficiency; these experimentally produce shock and tissue injury, especially of the intestine. Magnesium 126-135 interleukin 6 Homo sapiens 92-96 8712421-0 1996 Protamine and acute depletion of magnesium limit bone response to parathyroid hormone. Magnesium 33-42 parathyroid hormone Homo sapiens 66-85 8712421-12 1996 Bone showed reversible loss of response to parathyroid hormone after incubation in magnesium-free solution, E/C = 0.93 (P = NS). Magnesium 83-92 parathyroid hormone Homo sapiens 43-62 8712421-14 1996 Since protamine blocks parathyroid receptors, and magnesium depletion limits the bone"s response to parathyroid hormone, this may explain the persistent hypocalcemia seen in some patients undergoing cardiopulmonary bypass. Magnesium 50-59 parathyroid hormone Homo sapiens 100-119 8574094-3 1996 Magnesium also bound to ceruloplasmin, with Kd = 0.3 and 0.7 mM for the human and sheep protein, respectively. Magnesium 0-9 ceruloplasmin Homo sapiens 24-37 8689241-7 1996 This predicted structure is stabilized by the binding of magnesium ion with the sp2 oxygens present in quinolone, a phosphate and a purine base of the DNA. Magnesium 57-66 Sp2 transcription factor Homo sapiens 80-83 8952069-5 1996 Maternal RNAs encoding poly (A) binding protein (PABP), Vg1 and Xcat-2 were associated with large complexes that, in contrast to polysomes, were not dissociated in magnesium-free buffer. Magnesium 164-173 poly(A) binding protein, cytoplasmic 1 S homeolog Xenopus laevis 49-53 8952069-5 1996 Maternal RNAs encoding poly (A) binding protein (PABP), Vg1 and Xcat-2 were associated with large complexes that, in contrast to polysomes, were not dissociated in magnesium-free buffer. Magnesium 164-173 nanos homolog 1 L homeolog Xenopus laevis 64-70 9131802-1 1996 Azidometalkojates of the general formula MX2 (M = Cu, Mn, Mg, Zn or Ni and X = 5-hydroxy-2-azidomethyl-4H-pyran-4-one) were prepared and tested for antibacterial, antifungal and cytotoxic effects. Magnesium 58-60 MX dynamin like GTPase 2 Homo sapiens 41-44 8809584-3 1996 Somatostatin infusion significantly reduced the daily bile loss from median 473 ml to 140 ml (41 per cent, p = 0.01) with a concomitant significant reduction in the daily molar loss of cholesterol, triglyceride, Na+, K+, Cl-, Ca+2 and Mg+2. Magnesium 235-237 somatostatin Homo sapiens 0-12 8556237-5 1996 According to the literature, a possible reason for greater ATP J coupling constants is a smaller fraction of ATP complexed to magnesium. Magnesium 126-135 ATPase phospholipid transporting 8A2 Homo sapiens 59-62 8556237-5 1996 According to the literature, a possible reason for greater ATP J coupling constants is a smaller fraction of ATP complexed to magnesium. Magnesium 126-135 ATPase phospholipid transporting 8A2 Homo sapiens 109-112 8556237-6 1996 However, the chemical-shift difference between alpha- and beta-ATP, which is also a measure for the fraction of ATP complexed to magnesium, showed only a small difference in ATP complexation: 88% in myocardium and 90% in calf muscle. Magnesium 129-138 ATPase phospholipid transporting 8A2 Homo sapiens 112-115 8556237-6 1996 However, the chemical-shift difference between alpha- and beta-ATP, which is also a measure for the fraction of ATP complexed to magnesium, showed only a small difference in ATP complexation: 88% in myocardium and 90% in calf muscle. Magnesium 129-138 ATPase phospholipid transporting 8A2 Homo sapiens 112-115 8893212-0 1996 Effect of intravenous recombinant erythropoietin administration on plasma and erythrocyte magnesium concentrations in patients on hemodialysis. Magnesium 90-99 erythropoietin Homo sapiens 34-48 8730435-0 1996 Renin immunochemistry, sodium excretion and relative heart weight in cyclosporine- or alimentary-induced magnesium deficiency in rats. Magnesium 105-114 renin Rattus norvegicus 0-5 8730861-5 1996 Elevated levels of ions, particularly magnesium and calcium ions, abrogated the cytotoxic effect by preventing the Vpr peptides from entering the cells. Magnesium 38-47 Vpr Human immunodeficiency virus 1 115-118 8721753-5 1996 Incubation of these two preparations resulted in a Mg-ATP-dependent inactivation of NR that was reversed with EDTA. Magnesium 51-53 nitrate reductase 1 Arabidopsis thaliana 84-86 8789091-5 1996 Spontaneous transitions between H and L were slow; it took 4.5 min for L-->H, and 3.2 min for H-->L. These slow conversions among subconductance states of the CFTR channel were affected by extracellular Mg; in the presence of millimolar Mg, the channel remained stable in the H state. Magnesium 209-211 CF transmembrane conductance regulator Homo sapiens 165-169 8789091-5 1996 Spontaneous transitions between H and L were slow; it took 4.5 min for L-->H, and 3.2 min for H-->L. These slow conversions among subconductance states of the CFTR channel were affected by extracellular Mg; in the presence of millimolar Mg, the channel remained stable in the H state. Magnesium 243-245 CF transmembrane conductance regulator Homo sapiens 165-169 8777958-0 1996 Skeletal muscle magnesium and potassium in asthmatics treated with oral beta 2-agonists. Magnesium 16-25 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 72-78 8777958-6 1996 Skeletal muscle magnesium in the asthmatics was lower both before (3.62 +/- 0.69 mmol.100 g-1 (mean +/- SD)) and after (3.43 +/- 0.60 mmol.100 g-1) withdrawal of oral beta 2-agonists compared with the controls (4.43 +/- 0.74 mmol.100 g-1). Magnesium 16-25 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 167-173 8842030-0 1996 In vivo assessment of free magnesium concentration in human brain by 31P MRS. Magnesium 27-36 MROS Homo sapiens 73-76 8842030-5 1996 Our experiments resulted in a simple and reliable equation directly usable to assess in vivo the free cytosolic magnesium concentration of human brain by 31P MRS. Magnesium 112-121 MROS Homo sapiens 158-161 8677192-2 1996 Much less known is the physiological importance of ANP in the metabolism of other electrolytes e.g. calcium and magnesium, which are presumably involved in the pathogenesis of active renal stone disease (ARSD). Magnesium 112-121 natriuretic peptide A Homo sapiens 51-54 8878363-3 1996 The chemical analysis of fog during 32 episodes of local fog (pH, chloride, nitrate, sulphate, sodium, ammonia, potassium, magnesium, calcium) has shown a greater concentration of pollutants and greater acidity in the smaller particles (2-6 microns) which are able to penetrate the bronchial tree. Magnesium 123-132 zinc finger protein, FOG family member 1 Homo sapiens 25-28 8865442-2 1996 We have evaluated an instrument (AVL 988/4) which determines ionized magnesium (cMg2+) with an ion-selective electrode based on the ionophore ETH 7025. Magnesium 69-78 ANTXR cell adhesion molecule 2 Homo sapiens 80-84 8562571-4 1995 The increase in plasma apolipoprotein B concentration indicated that a corresponding increase in plasma triacylglycerol-rich lipoproteins (TGRLP) occurred in Mg-deficient animals. Magnesium 158-160 apolipoprotein B Rattus norvegicus 23-39 7497618-0 1995 Intracellular magnesium content of mononuclear blood cells and granulocytes isolated from leukemic, infected, and granulocyte colony-stimulating factor-treated patients. Magnesium 14-23 colony stimulating factor 3 Homo sapiens 114-151 7499369-2 1995 Magnesium ion alone (10 mM) stabilizes GroEL and leads to coordination of the structural transitions monitored by the different parameters. Magnesium 0-9 heat shock protein family D (Hsp60) member 1 Homo sapiens 39-44 8861135-0 1995 Magnesium transport induced ex vivo by a pharmacological dose of insulin is impaired in non-insulin-dependent diabetes mellitus. Magnesium 0-9 insulin Homo sapiens 65-72 8861135-3 1995 Magnesium deficiency per se has also been reported to result in insulin resistance. Magnesium 0-9 insulin Homo sapiens 64-71 8861135-11 1995 and the insulin-induced rise in Mg(2+) fell from 27.2 percent pre-magnesium depletion to 12.7 percent post-magnesium depletion. Magnesium 32-34 insulin Homo sapiens 8-15 8861135-11 1995 and the insulin-induced rise in Mg(2+) fell from 27.2 percent pre-magnesium depletion to 12.7 percent post-magnesium depletion. Magnesium 66-75 insulin Homo sapiens 8-15 8861135-11 1995 and the insulin-induced rise in Mg(2+) fell from 27.2 percent pre-magnesium depletion to 12.7 percent post-magnesium depletion. Magnesium 107-116 insulin Homo sapiens 8-15 8861135-12 1995 These data suggest that insulin resistance and magnesium depletion may result in a vicious cycle of worsening insulin resistance and decrease in intracellular Mg(2+) which may limit the role of magnesium in vital cellular processes. Magnesium 47-56 insulin Homo sapiens 110-117 8861135-12 1995 These data suggest that insulin resistance and magnesium depletion may result in a vicious cycle of worsening insulin resistance and decrease in intracellular Mg(2+) which may limit the role of magnesium in vital cellular processes. Magnesium 194-203 insulin Homo sapiens 24-31 8861136-3 1995 After surgery, serum magnesium showed a minor increase on d 3 and d 9 (P < 0.05) and a return to initial levels on d 27 and d 45 after surgery. Magnesium 21-30 iodothyronine deiodinase 3 Homo sapiens 58-69 7493018-2 1995 Casr+/- mice, analogous to humans with familial hypocalciuric hypercalcemia, had benign and modest elevations of serum calcium, magnesium and parathyroid hormone levels as well as hypocalciuria. Magnesium 128-137 calcium-sensing receptor Mus musculus 0-4 8720036-4 1995 (2) ANP infusion significantly increased urine flow rate (UFR), creatinine clearance (CCr), fractional excretion rates of sodium (FENa) and chloride (FECl), and urinary phosphorus and magnesium (Mg) excretions in a dose-dependent manner without affecting renal plasma flow and fractional excretion rates of potassium and urea in cisplatin-treated rats. Magnesium 195-197 natriuretic peptide A Rattus norvegicus 4-7 8720036-5 1995 (3) Renal effects of ANP on UFR, CCr, FENa, FECl and excretion of Mg were more pronounced in cisplatin-treated rats compared to control rats although markedly blunted responses to ANP have been reported in nephrotic patients and nephrotic animals induced by adriamycin and aminonucleoside. Magnesium 66-68 natriuretic peptide A Rattus norvegicus 21-24 8563701-7 1995 Although there was no difference in excretion of calcium, magnesium and phosphate between the two kidneys under basal conditions, infusion of ANG II or PE induced hypercalciuria, hypermagnesiuria and hyperphosphaturia in the right kidney which was exposed to the increased arterial pressure. Magnesium 58-67 angiotensinogen Rattus norvegicus 142-148 8563701-9 1995 Infusion of AVP was associated with reduced excretion of calcium and magnesium, and increased excretion of phosphate, in the normotensive kidney. Magnesium 69-78 arginine vasopressin Rattus norvegicus 12-15 7487056-1 1995 Engineering magnesium selectivity into the helix-loop-helix (hlh) cation binding site is relatively unstudied in the calmodulin superfamily of calcium-regulated proteins, which include parvalbumin, oncomodulin, troponin C, calbindin, and calmodulin. Magnesium 12-21 calmodulin 1 Homo sapiens 117-127 8619297-3 1995 Adding magnesium (0.125-1.2 mM) throughout the experiment reversed the action of the decreased sodium medium and contributed to the preservation of high concentrations of energy-rich compounds, to that of mitochondrial conjugation of oxidation and phosphorylation, to more than 4-fold cardiac release of myoglobin. Magnesium 7-16 myoglobin Rattus norvegicus 304-313 7487056-1 1995 Engineering magnesium selectivity into the helix-loop-helix (hlh) cation binding site is relatively unstudied in the calmodulin superfamily of calcium-regulated proteins, which include parvalbumin, oncomodulin, troponin C, calbindin, and calmodulin. Magnesium 12-21 parvalbumin Homo sapiens 185-196 7487056-1 1995 Engineering magnesium selectivity into the helix-loop-helix (hlh) cation binding site is relatively unstudied in the calmodulin superfamily of calcium-regulated proteins, which include parvalbumin, oncomodulin, troponin C, calbindin, and calmodulin. Magnesium 12-21 calbindin 1 Homo sapiens 223-232 7487056-1 1995 Engineering magnesium selectivity into the helix-loop-helix (hlh) cation binding site is relatively unstudied in the calmodulin superfamily of calcium-regulated proteins, which include parvalbumin, oncomodulin, troponin C, calbindin, and calmodulin. Magnesium 12-21 calmodulin 1 Homo sapiens 238-248 33867678-6 1995 To date, lifetime probes for analyte recognition (binding) have been identified for Ca 2+, Mg 2 +, K + and pH. Magnesium 91-93 phenylalanine hydroxylase Homo sapiens 107-109 7579398-7 1995 The results indicate that idiotype-reactive T cells of the Th1 and Th2 or Th0 subsets were present in MGs and might provide indirect evidence that idiotype-reactive Th1-type cells may have a regulatory impact on the human tumor B cells. Magnesium 102-105 negative elongation factor complex member C/D Homo sapiens 59-62 7579398-7 1995 The results indicate that idiotype-reactive T cells of the Th1 and Th2 or Th0 subsets were present in MGs and might provide indirect evidence that idiotype-reactive Th1-type cells may have a regulatory impact on the human tumor B cells. Magnesium 102-105 negative elongation factor complex member C/D Homo sapiens 165-168 8523447-2 1995 For determination of calcium- and magnesium-dependent binding of the compounds to cTnC a new type of cTnC-HPLAC column was used. Magnesium 34-43 troponin C1, slow skeletal and cardiac type Homo sapiens 82-86 7557436-3 1995 Conditions of stress that lead to the release of Nef include elevated levels of copper or magnesium ions or growth at elevated temperatures. Magnesium 90-99 S100 calcium binding protein B Homo sapiens 49-52 8523447-2 1995 For determination of calcium- and magnesium-dependent binding of the compounds to cTnC a new type of cTnC-HPLAC column was used. Magnesium 34-43 troponin C1, slow skeletal and cardiac type Homo sapiens 101-105 8523447-4 1995 Only levosimendan showed calcium-dependent and to a lesser extent magnesium-dependent retention in the cTnC column. Magnesium 66-75 troponin C1, slow skeletal and cardiac type Homo sapiens 103-107 7573390-0 1995 Effects of magnesium on nitric oxide synthase activity in endothelial cells. Magnesium 11-20 nitric oxide synthase 2 Homo sapiens 24-45 8528083-3 1995 When the hydrophobic segments of the IL-1R were aligned with similar segments of the GTPases, it became apparent that the IL-1Rs possess a number of conserved amino acids that represent plausible functional residues for base-specific binding of GTP, magnesium chelation, and phosphate ester hydrolysis. Magnesium 250-259 interleukin 1 receptor type 1 Homo sapiens 37-42 8549022-2 1995 Insulin sensitivity can be improved by reduction of excessive body weight, regular physical activity and, possibly, by correcting a subclinical magnesium deficiency. Magnesium 144-153 insulin Homo sapiens 0-7 8593186-3 1995 To determine the effects of these substitutions on the three-dimensional structure of the whole p21 protein, we have performed molecular dynamics calculations on each of these three proteins bound to GDP and magnesium ion to compute the average structures of each of the three forms. Magnesium 208-217 H3 histone pseudogene 16 Homo sapiens 96-99 7501705-1 1995 Magnesium (Mg2+) is one of the most abundant ions in the body. Magnesium 0-9 mucin 7, secreted Homo sapiens 11-14 7501705-6 1995 The results can be summarized as follows: (1) Reduction of the concentration of magnesium [Mg2+] from normal Tyrode"s solution enhanced the spontaneous basal activity, whereas addition of Mg2+ gradually abolished this spontaneous activity. Magnesium 80-89 mucin 7, secreted Homo sapiens 91-94 8527730-1 1995 Phosphorus magnetic resonance spectroscopy was used to determine effects of acute and chronic alcohol exposure on brain intracellular free magnesium concentration (Mgf) and bioenergetic state in rats. Magnesium 139-148 KIT ligand Rattus norvegicus 164-167 7677250-7 1995 Within-run relative standard deviations for the method at 4.8, 24 and 120 micrograms l-1 of magnesium were 3.5, 1.2 and 0.7%, respectively. Magnesium 92-101 immunoglobulin kappa variable 1-16 Homo sapiens 85-88 7587003-0 1995 Insulin increases renal magnesium excretion: a possible cause of magnesium depletion in hyperinsulinaemic states. Magnesium 24-33 insulin Homo sapiens 0-7 7587003-0 1995 Insulin increases renal magnesium excretion: a possible cause of magnesium depletion in hyperinsulinaemic states. Magnesium 65-74 insulin Homo sapiens 0-7 7587003-4 1995 Compared to baseline, the renal magnesium excretion increased 30% during the infusion of insulin at a rate of 120 pmol m-2 min-1. Magnesium 32-41 insulin Homo sapiens 89-96 7587003-4 1995 Compared to baseline, the renal magnesium excretion increased 30% during the infusion of insulin at a rate of 120 pmol m-2 min-1. Magnesium 32-41 CD59 molecule (CD59 blood group) Homo sapiens 123-128 7587003-5 1995 During infusion of insulin, 240 pmol m-2 min-1, renal magnesium excretion increased 50% compared to baseline. Magnesium 54-63 insulin Homo sapiens 19-26 7587003-5 1995 During infusion of insulin, 240 pmol m-2 min-1, renal magnesium excretion increased 50% compared to baseline. Magnesium 54-63 CD59 molecule (CD59 blood group) Homo sapiens 41-46 7587003-8 1995 Thus, physiological concentrations of insulin induce a specific increase in the renal excretion of magnesium. Magnesium 99-108 insulin Homo sapiens 38-45 7542661-0 1995 Magnesium-dependent stimulation of protein synthesis by the insulin mimic, pervanadate. Magnesium 0-9 insulin Bos taurus 60-67 7546495-8 1995 The increase in intraerythrocyte magnesium correlated negatively with the fall in mean blood pressure and positively with the increase in Kos, which correlated negatively with the decrease in intraerythrocyte sodium. Magnesium 33-42 ubiquitin protein ligase E3B Homo sapiens 138-141 7626055-4 1995 Calcium and magnesium ions at mM levels affect the antiaggregation action exerted by alpha-crystallin either interfering on the formation or reducing the stability of the aldose reductase: alpha-crystallin complex. Magnesium 12-21 aldose reductase Bos taurus 171-187 7576598-0 1995 The secretion of parathyroid hormone-related protein in the saliva of sheep and its effects on the salivary clearance of phosphate, calcium, magnesium, potassium and sodium ions. Magnesium 141-150 parathyroid hormone-related protein Ovis aries 17-52 7768957-5 1995 In contrast, MMP-1 expression was induced in KHOS-240 and MG-63 cells but not in HOS cells. Magnesium 58-60 matrix metallopeptidase 1 Homo sapiens 13-18 7782801-9 1995 In participants without CVD, serum Mg levels were also inversely associated with fasting serum insulin, glucose, systolic blood pressure and smoking. Magnesium 35-37 insulin Homo sapiens 95-102 7782801-10 1995 Dietary Mg intake was inversely associated with fasting serum insulin, plasma high density lipoprotein-cholesterol, systolic and diastolic blood pressure. Magnesium 8-10 insulin Homo sapiens 62-69 7540041-1 1995 The splicing factor CBP2 is required to excise the yeast mitochondrial group I intron bI5 in vivo and at low magnesium ion concentrations in vitro. Magnesium 109-118 Cbp2p Saccharomyces cerevisiae S288C 20-24 7540041-5 1995 At low (5 mM) magnesium ion, reaction (measured as kcat/Km or kcat) is accelerated 3 orders of magnitude by saturating CBP2. Magnesium 14-23 Cbp2p Saccharomyces cerevisiae S288C 119-123 7578774-6 1995 These results suggested that two different types of Mg-containing fluoridated hydroxyapatites might be formed: surface fluoride-rich apatites (Mg-MgFAp) and inner fluoride-rich apatites (MgF-MgAp). Magnesium 52-54 signal transducer and activator of transcription 5A Homo sapiens 146-149 7578774-6 1995 These results suggested that two different types of Mg-containing fluoridated hydroxyapatites might be formed: surface fluoride-rich apatites (Mg-MgFAp) and inner fluoride-rich apatites (MgF-MgAp). Magnesium 52-54 MAX dimerization protein MGA Homo sapiens 191-195 8586780-1 1995 OBJECTIVE: The present study was undertaken to investigate the effect of dietary magnesium (Mg) deficiency on plasma levels of parathyroid hormone (PTH) and calcitonin (CT), and the changes in tissue calcium (Ca) and phosphorus (P) content. Magnesium 81-90 parathyroid hormone Rattus norvegicus 127-146 7641846-3 1995 Phosphatidylethanolamine N-methyltransferase (PE N-MTase) has two pH optima, 8.5 and 10, at low (10 microM) and high (200 microM) SAM concentrations and requires magnesium ions for full activity. Magnesium 162-171 phosphatidylethanolamine N-methyltransferase Bos taurus 0-44 7641846-3 1995 Phosphatidylethanolamine N-methyltransferase (PE N-MTase) has two pH optima, 8.5 and 10, at low (10 microM) and high (200 microM) SAM concentrations and requires magnesium ions for full activity. Magnesium 162-171 phosphatidylethanolamine N-methyltransferase Bos taurus 46-56 8586780-0 1995 Changes in tissue calcium and phosphorus content and plasma concentrations of parathyroid hormone and calcitonin after long-term magnesium deficiency in rats. Magnesium 129-138 parathyroid hormone Rattus norvegicus 78-97 7650659-8 1995 Serum levels of Mg++ in patients with underlying PIH were significantly higher at the same intravenous infusion rate. Magnesium 16-20 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 49-52 7650659-10 1995 PIH should require lower infusion rates to achieve therapeutic serum levels of Mg++. Magnesium 79-83 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 0-3 8592513-8 1995 Molybdate also stabilizes both p23 and PR complexes under conditions of low ATP and magnesium concentration. Magnesium 84-93 progesterone receptor Oryctolagus cuniculus 39-41 7663172-2 1995 It is based on a specific interaction between leukotriene C4 synthase and microsomal glutathione S-transferase which occurs in the presence of magnesium ion. Magnesium 143-152 leukotriene C4 synthase Homo sapiens 46-69 7714113-0 1995 Effects of insulin on plasma magnesium in noninsulin-dependent diabetes mellitus: evidence for insulin resistance. Magnesium 29-38 insulin Homo sapiens 11-18 7714113-1 1995 Insulin influences both glucose metabolism and magnesium homeostasis in humans. Magnesium 47-56 insulin Homo sapiens 0-7 7714113-2 1995 The present studies sought to determine whether insulin-induced stimulation of magnesium uptake is impaired in noninsulin-dependent diabetes mellitus (NIDDM) and enhanced by acute hyperglycemia. Magnesium 79-88 insulin Homo sapiens 48-55 7714113-5 1995 During the prandial insulin infusion, the decrement in the plasma magnesium concentration was lower (P < 0.05) in the diabetic patients than that in the nondiabetic subjects during both the euglycemic (4.1 +/- 0.9 vs. 7.8 +/- 1.3 mmol/L.4 h) and hyperglycemic (1.7 +/- 1.1 vs. 6.6 +/- 1.4 mmol/L.4 h) studies. Magnesium 66-75 insulin Homo sapiens 20-27 7714113-6 1995 Glucose disappearance also was lower (P < 0.05) in the diabetic patients than that in the nondiabetic subjects, and the insulin-induced decrement in plasma magnesium was correlated (P < 0.01) with glucose disappearance. Magnesium 159-168 insulin Homo sapiens 123-130 7714113-8 1995 We conclude that insulin resistance in subjects with NIDDM impairs the ability of insulin to stimulate magnesium as well as glucose uptake. Magnesium 103-112 insulin Homo sapiens 17-24 7714113-8 1995 We conclude that insulin resistance in subjects with NIDDM impairs the ability of insulin to stimulate magnesium as well as glucose uptake. Magnesium 103-112 insulin Homo sapiens 82-89 7714114-2 1995 Magnesium accumulation is dependent upon insulin action and correlates with insulin-mediated glucose uptake. Magnesium 0-9 insulin Homo sapiens 41-48 7714114-2 1995 Magnesium accumulation is dependent upon insulin action and correlates with insulin-mediated glucose uptake. Magnesium 0-9 insulin Homo sapiens 76-83 7714114-3 1995 As Pima Indians are known to be insulin resistant, we investigated whether, in response to insulin infusion, they have lower erythrocyte magnesium accumulation than Caucasians. Magnesium 137-146 insulin Homo sapiens 91-98 7714114-8 1995 In response to insulin infusion, erythrocyte magnesium content increased less in Pima Indians than in Caucasians (0.15 +/- 0.07 vs. 0.28 +/- 0.21 mmol/L; P < 0.03). Magnesium 45-54 insulin Homo sapiens 15-22 7714114-10 1995 In conclusion, nondiabetic Pima Indians have a lower erythrocyte magnesium accumulation in response to insulin infusion; this is probably due to their high degree of insulin resistance. Magnesium 65-74 insulin Homo sapiens 103-110 7722684-5 1995 The blood pressure-lowering effect of magnesium supplementation in DOCA-salt hypertensive rats was associated with a lower in vivo cardiovascular reactivity to norepinephrine and angiotensin II. Magnesium 38-47 angiotensinogen Rattus norvegicus 179-193 7534750-10 1995 Daudi expressed alpha 5 beta 1 in a non-functional configuration which was rendered functional only upon applying high concentrations of Mg++ and Mn++. Magnesium 137-141 olfactory receptor family 51 subfamily B member 4 Mus musculus 22-30 7876632-1 1995 A sandwich ELISA was developed specific for human bactericidal/permeability-increasing protein (BPI), using Mg++ ions to abrogate disturbance by lipopolysaccharide of BPI measurement and to prevent aspecific adherence of BPI to solid phase. Magnesium 108-112 bactericidal permeability increasing protein Homo sapiens 50-94 7876632-1 1995 A sandwich ELISA was developed specific for human bactericidal/permeability-increasing protein (BPI), using Mg++ ions to abrogate disturbance by lipopolysaccharide of BPI measurement and to prevent aspecific adherence of BPI to solid phase. Magnesium 108-112 bactericidal permeability increasing protein Homo sapiens 96-99 7876632-1 1995 A sandwich ELISA was developed specific for human bactericidal/permeability-increasing protein (BPI), using Mg++ ions to abrogate disturbance by lipopolysaccharide of BPI measurement and to prevent aspecific adherence of BPI to solid phase. Magnesium 108-112 bactericidal permeability increasing protein Homo sapiens 167-170 7876632-1 1995 A sandwich ELISA was developed specific for human bactericidal/permeability-increasing protein (BPI), using Mg++ ions to abrogate disturbance by lipopolysaccharide of BPI measurement and to prevent aspecific adherence of BPI to solid phase. Magnesium 108-112 bactericidal permeability increasing protein Homo sapiens 167-170 7636446-2 1995 The present study examines the effect of pH and free magnesium levels (free [Mg2+]) on the apparent equilibrium constants (K") of creatine kinase (ATP: creatine N-phosphotransferase; EC 2.7.3.2), adenylate kinase (ATP:AMP phosphotransferase; EC 2.7.4.3) and adenosinetriphosphatase (ATP phosphohydrolase; EC 3.6.1.3) reactions. Magnesium 53-62 ATPase phospholipid transporting 8A2 Homo sapiens 147-150 7538128-3 1995 Calcium or magnesium can completely inhibit the binding of AP5 to alpha IIb beta 3 on platelets, with ID50 values of 80 and 1500 microM, respectively. Magnesium 11-20 adaptor related protein complex 5 subunit beta 1 Homo sapiens 59-62 7538128-5 1995 In the presence of 1 mM calcium plus 1 mM magnesium, the peptide RGDW overcomes this inhibition and induces maximal binding of AP5. Magnesium 42-51 adaptor related protein complex 5 subunit beta 1 Homo sapiens 127-130 7766705-2 1995 In the present study, cyclooxygenase 1 (COX1) was shown constitutively expressed in mouse adherent and non-adherent macrophages whereas expression of COX2 was observed only in adherent cells, even when cultured in minimal conditions (Ca-, Mg- and serum-free medium). Magnesium 239-241 prostaglandin-endoperoxide synthase 1 Mus musculus 22-38 7766705-2 1995 In the present study, cyclooxygenase 1 (COX1) was shown constitutively expressed in mouse adherent and non-adherent macrophages whereas expression of COX2 was observed only in adherent cells, even when cultured in minimal conditions (Ca-, Mg- and serum-free medium). Magnesium 239-241 prostaglandin-endoperoxide synthase 1 Mus musculus 40-44 7766705-3 1995 The COX2 expression was amplified by arachidonic acid cascade stimulating agents (Ca, Mg, zymosan) and by LPS in a time-dependant manner; PGE2 by itself amplified LPS-induced COX2 expression. Magnesium 86-88 cytochrome c oxidase II, mitochondrial Mus musculus 4-8 7546215-2 1995 Using electron spin resonance spectroscopy, we have demonstrated that vanadyl, vanadium (IV), the predominant intracellular form of vanadate (vanadium V), binds to calmodulin in the presence of physiological concentrations of magnesium, extending earlier work which showed competitive binding of vanadyl and calcium to calmodulin. Magnesium 226-235 calmodulin Oryctolagus cuniculus 164-174 7546215-2 1995 Using electron spin resonance spectroscopy, we have demonstrated that vanadyl, vanadium (IV), the predominant intracellular form of vanadate (vanadium V), binds to calmodulin in the presence of physiological concentrations of magnesium, extending earlier work which showed competitive binding of vanadyl and calcium to calmodulin. Magnesium 226-235 calmodulin Oryctolagus cuniculus 319-329 7663422-2 1995 The effect is small and dependent on the ionized magnesium concentration ([Mg2+]free), only resulting in a significant increase in the measured [Mg2+]free with spermine and spermidine at [Mg2+]free less than 0.5 mM. Magnesium 49-58 mucin 7, secreted Homo sapiens 75-78 7663422-2 1995 The effect is small and dependent on the ionized magnesium concentration ([Mg2+]free), only resulting in a significant increase in the measured [Mg2+]free with spermine and spermidine at [Mg2+]free less than 0.5 mM. Magnesium 49-58 mucin 7, secreted Homo sapiens 145-148 7663422-2 1995 The effect is small and dependent on the ionized magnesium concentration ([Mg2+]free), only resulting in a significant increase in the measured [Mg2+]free with spermine and spermidine at [Mg2+]free less than 0.5 mM. Magnesium 49-58 mucin 7, secreted Homo sapiens 145-148 7537775-0 1995 Changes in the concentrations of extracellular Mg++ and Ca++ down-regulate E-cadherin and up-regulate alpha 2 beta 1 integrin function, activating keratinocyte migration on type I collagen. Magnesium 47-51 cadherin 1 Homo sapiens 75-85 7537775-8 1995 Together these data suggest that changes in the concentrations of extracellular Mg++ and Ca++ can regulate the competitive interplay between Ca(++)-dependent E-cadherin-mediated and Mg(++)-dependent alpha 2 beta 1-integrin-mediated adhesion, promoting the development of an activated keratinocyte phenotype. Magnesium 80-84 cadherin 1 Homo sapiens 158-168 7595597-2 1995 Kainate and GLU caused a dose-related, calcium-dependent, magnesium-blocked liberation of AChE soluble forms (mainly G4) from both the ventral and dorsal horns, without membrane damage. Magnesium 58-67 acetylcholinesterase Mus musculus 90-94 7592564-6 1995 Bacterial and plant PBGS use a third metal ion, magnesium, as an allosteric activator. Magnesium 48-57 aminolevulinate dehydratase Homo sapiens 20-24 7592564-7 1995 In addition, some bacterial and plant PBGS may use magnesium in place of one or both of the zinc ions of mammalian PBGS. Magnesium 51-60 aminolevulinate dehydratase Homo sapiens 38-42 7608827-2 1995 Patients with low magnesium status (n = 7) had significantly lower levels of cholesterol, HDL cholesterol, and apolipoprotein A-1 than those with normal magnesium status (n = 20); however, there were no significant differences between the groups in serum concentrations of magnesium and apolipoprotein B. Magnesium 18-27 apolipoprotein A1 Homo sapiens 111-129 7608827-3 1995 These data suggest that magnesium deficiencies are associated with low serum concentration of HDL cholesterol and apolipoprotein A-1. Magnesium 24-33 apolipoprotein A1 Homo sapiens 114-132 7762157-5 1995 GTP gamma S stimulated only the PI-PLC activity associated with membrane and was magnesium dependent. Magnesium 81-90 phospholipase C gamma 1 Homo sapiens 32-38 7702580-4 1995 By use of a fluorescent ligand, the macrophage beta-glucan receptor was shown to be trypsin-sensitive, Ca2+/Mg(2+)-independent, recirculating and also present in an intracellular mobilizable pool. Magnesium 108-110 C-type lectin domain family 7, member a Mus musculus 47-67 7613104-3 1995 BU and IPSA reduced the frequency of occurrence of low magnesium induced field potentials in CA1 and CA3 areas of the hippocampus slice preparation (guinea pigs) in a dose dependent manner. Magnesium 55-64 carbonic anhydrase 1 Cavia porcellus 93-96 7613104-3 1995 BU and IPSA reduced the frequency of occurrence of low magnesium induced field potentials in CA1 and CA3 areas of the hippocampus slice preparation (guinea pigs) in a dose dependent manner. Magnesium 55-64 carbonic anhydrase 3 Cavia porcellus 101-104 7783102-0 1995 Low fasting and insulin-mediated intracellular magnesium accumulation in hypertensive patients with left ventricular hypertrophy: role of insulin resistance. Magnesium 47-56 insulin Homo sapiens 16-23 7783102-8 1995 In conclusion, hypertensive patients with LVH compared with those without LVH have a lower intracellular magnesium content due a higher degree of insulin resistance. Magnesium 105-114 insulin Homo sapiens 146-153 7669510-2 1995 PTH stimulates magnesium reabsorption in the renal tubule, absorption in the gut and release of the ion from bone. Magnesium 15-24 parathyroid hormone Homo sapiens 0-3 8586780-1 1995 OBJECTIVE: The present study was undertaken to investigate the effect of dietary magnesium (Mg) deficiency on plasma levels of parathyroid hormone (PTH) and calcitonin (CT), and the changes in tissue calcium (Ca) and phosphorus (P) content. Magnesium 92-94 parathyroid hormone Rattus norvegicus 127-146 7669510-3 1995 Magnesium on the other hand is essential for the normal function of the parathyroid glands, metabolism of vitamin D and adequate sensitivity of target tissues to PTH and active vitamin D metabolites. Magnesium 0-9 parathyroid hormone Homo sapiens 162-165 7669510-4 1995 Magnesium deficit is usually associated with hypoparathyroidism, low production of active vitamin D metabolites, in particular 1,25(OH)2 vitamin D3 and resistance to PTH and vitamin D. Magnesium 0-9 parathyroid hormone Homo sapiens 166-169 7752984-3 1995 Significantly lower serum total calcium, urinary calcium and magnesium excretions and plasma renin activity were evident in women with PIH. Magnesium 61-70 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 135-138 7669510-5 1995 On the contrary, magnesium excess, similar to calcium, inhibits PTH secretion. Magnesium 17-26 parathyroid hormone Homo sapiens 64-67 7669512-2 1995 The magnesium concentration of human milk is about 30 mg/litre, while infant formulas provide about 40-80 mg/litre and cows milk approximately 130 mg/litre. Magnesium 4-13 Weaning weight-maternal milk Bos taurus 37-41 7669512-5 1995 Limited studies in preterm and term infants also indicate a high level of magnesium absorption (55-75 per cent) from human milk and milk-based formulas. Magnesium 74-83 Weaning weight-maternal milk Bos taurus 123-127 16031800-3 1995 A severe cyclonic disturbance in early 1988, Cyclone Bola, was associated with changes in pasture sodium, potassium and magnesium, urinary sodium, and serum magnesium concentrations. Magnesium 120-129 MHC class I antigen clone 2 Bos taurus 53-57 16031800-3 1995 A severe cyclonic disturbance in early 1988, Cyclone Bola, was associated with changes in pasture sodium, potassium and magnesium, urinary sodium, and serum magnesium concentrations. Magnesium 157-166 MHC class I antigen clone 2 Bos taurus 53-57 7708849-3 1995 Among the various available materials, the relatively new LiF:Mg,Cu,P phosphor is a suitable candidate for quality control of in vivo dosimetry in electron-beam therapy. Magnesium 62-64 LIF interleukin 6 family cytokine Homo sapiens 58-61 7540318-0 1995 [Changes of cytoplasmic calcium and magnesium concentration and calcium distribution in human platelets caused by thrombin]. Magnesium 36-45 coagulation factor II, thrombin Homo sapiens 114-122 7529764-6 1995 The K8/18-hsp/c70 complex can be dissociated in a Mg-ATP-dependent manner that requires ATP hydrolysis. Magnesium 50-52 keratin 8 Homo sapiens 4-9 7529764-6 1995 The K8/18-hsp/c70 complex can be dissociated in a Mg-ATP-dependent manner that requires ATP hydrolysis. Magnesium 50-52 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 10-13 7798920-3 1995 Translation of full-length DBH with microsomal membranes generated two glycosylated products (GH and GL) depending on the magnesium concentration. Magnesium 122-131 dopamine beta-hydroxylase Rattus norvegicus 27-30 7660095-11 1995 Among other effects, PTHrP might stimulate the secretion of calcium, phosphate and magnesium in milk and might foster the development of the mammary gland. Magnesium 83-92 parathyroid hormone like hormone Bos taurus 21-26 8592485-5 1995 The fractional Mg excretion was similarly reduced by endogenous CT (26.8 +/- 0.9 as compared with 37.3 +/- 2.1%; p < 0.01). Magnesium 15-17 calcitonin-related polypeptide alpha Rattus norvegicus 64-66 8592486-0 1995 Relations between magnesium, calcium, and plasma renin activity in black and white hypertensive patients. Magnesium 18-27 renin Homo sapiens 49-54 8592486-1 1995 The heterogeneous status of magnesium and calcium metabolism in the hypertensive population may be related to the plasma renin activity (PRA). Magnesium 28-37 renin Homo sapiens 121-126 7811699-1 1994 In the present study, the influence of magnesium-for-calcium exchange and phosphorylation of regulatory light chain (RLC) on accessibility of myosin and heavy meromyosin alkali light chains (A1) for papain digestion was investigated. Magnesium 39-48 myosin heavy chain 14 Homo sapiens 142-148 7697494-2 1994 The study of the physicochemical properties of Mag-indo-1, a fluorescent probe used for intracellular magnesium measurements, has shown that in a biological environment the deprotonated form of this probe is in simultaneous equilibrium with a protonated form, a protein and a magnesium-bound form. Magnesium 102-111 myelin associated glycoprotein Homo sapiens 47-50 7697494-2 1994 The study of the physicochemical properties of Mag-indo-1, a fluorescent probe used for intracellular magnesium measurements, has shown that in a biological environment the deprotonated form of this probe is in simultaneous equilibrium with a protonated form, a protein and a magnesium-bound form. Magnesium 276-285 myelin associated glycoprotein Homo sapiens 47-50 7949104-9 1994 The R-PK activity is expected to be severely affected, because the mutated amino acid residue is located between the 313 Lys and the 315 Glu, which are very important for acid-base catalysis and magnesium binding, respectively. Magnesium 195-204 pyruvate kinase L/R Homo sapiens 4-8 7965925-8 1994 Depolarization by either K+, Na+, Ca++ or Mg++ correlates with inhibition of both in vivo reductase activities and cytochrome c-induced membrane potential changes. Magnesium 42-46 cytochrome c, somatic Homo sapiens 115-127 7957891-1 1994 We describe here an easy system for the production of mg amounts of the rabbit Ca(2+)-ATPase SERCA 1a in the yeast S. cerevisiae. Magnesium 54-56 sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Oryctolagus cuniculus 93-101 7935767-4 1994 We show that Rad1 binds specifically to a Holliday junction and, in the presence of magnesium, catalyses the endonucleolytic cleavage of the junction. Magnesium 84-93 ssDNA endodeoxyribonuclease RAD1 Saccharomyces cerevisiae S288C 13-17 7847587-5 1994 In Mg depletion, there is often hypocalcemia due to impaired parathyroid hormone (PTH) secretion, as well as renal and skeletal resistance to PTH action. Magnesium 3-5 parathyroid hormone Homo sapiens 61-80 7553347-4 1994 In an experiment using haemolysate, the effect of calcium per se was negligible, while magnesium strongly affected GSH regeneration by controlling the rate of hexokinase reaction. Magnesium 87-96 hexokinase-2 Oryctolagus cuniculus 159-169 7896768-3 1994 Matrix free magnesium ion concentration, [Mg2+], can be measured using fluorescent probes and is set very close to cytosol [Mg2+] by a balance between influx and efflux and by the availability of ligands, such as Pi. Magnesium 12-21 mucin 7, secreted Homo sapiens 42-45 7896768-3 1994 Matrix free magnesium ion concentration, [Mg2+], can be measured using fluorescent probes and is set very close to cytosol [Mg2+] by a balance between influx and efflux and by the availability of ligands, such as Pi. Magnesium 12-21 mucin 7, secreted Homo sapiens 124-127 7525932-0 1994 Magnesium and zinc potentiate ethanol inhibition of N-methyl-D-aspartate-stimulated nitric oxide synthase in cortical neurons. Magnesium 0-9 nitric oxide synthase 2 Homo sapiens 84-105 7965724-4 1994 In both membrane preparations, NT binding was increased by Mg++ and decreased by Na+ and guanosine 5"-[gamma-thio]triphosphate, whereas SR 48692 binding was not significantly affected by these agents. Magnesium 59-63 neurotensin/neuromedin N Cavia porcellus 31-33 7811699-3 1994 Exchange of magnesium ions bound to RLCs for calcium ions accelerates the digestion of A1 in the presence of ATP in dephosphorylated myosin, heavy meromyosin, acto-myosin and the acto-heavy meromyosin complex. Magnesium 12-21 myosin heavy chain 14 Homo sapiens 133-170 7811699-4 1994 In the absence of ATP the exchange of magnesium ions bound to RLCs for calcium ions delays the digestion of A1 in the acto-myosin complex. Magnesium 38-47 myosin heavy chain 14 Homo sapiens 123-129 7918668-1 1994 Yeast calmodulin binds only three calcium ions in the presence of millimolar concentrations of magnesium due to a defective calcium-binding sequence in its carboxyl terminal domain. Magnesium 95-104 calmodulin Saccharomyces cerevisiae S288C 6-16 7937120-4 1994 We find that, although both oligonucleotides yield clear footprints at similar concentrations (0.3 microM) in the presence of manganese, only T11(TG)6 forms a stable complex in magnesium-containing buffers, albeit at a higher concentration (10-30 microM). Magnesium 177-186 transglutaminase 6 Homo sapiens 142-150 8085157-3 1994 When P4 and P6 were fused with a phosphodiester linkage, the resulting RNA retained the detailed tertiary interactions characteristic of the native P4-P6 domain and even required lower magnesium ion concentrations for folding. Magnesium 185-194 solute carrier family 10 member 4 Homo sapiens 5-14 7812848-5 1994 The increase of free Ca and decrease of free Mg concentrations participate both in insulin resistance and hemodynamic changes in diseases of the Reaven"s syndrome. Magnesium 45-47 insulin Homo sapiens 83-90 7820978-6 1994 In conclusion, the decrease of circulating CGRP after MgSO4 infusion in women with PRP provides further evidence that magnesium plays a significant role in the pathophysiology of PRP. Magnesium 118-127 calcitonin related polypeptide alpha Homo sapiens 43-47 7810200-4 1994 It is concluded that the constancy of the Ca/Mg ratio throughout the lifetime is an integral quality of elastic fibers which may be explained by the biological long half-life of elastin. Magnesium 45-47 elastin Homo sapiens 178-185 7755455-0 1994 [Concentration of free intracellular magnesium in the myocardium of spontaneously hypertensive rats treated chronically with calcium antagonist or angiotensin converting enzyme inhibitor]. Magnesium 37-46 angiotensin I converting enzyme Rattus norvegicus 147-176 8063817-6 1994 Other divalent cations, such as magnesium, zinc, nickel, and cobalt, but not the trivalent cation lanthanum, induced p62 phosphorylation to a similar extent as calcium. Magnesium 32-41 nucleoporin 62 Mus musculus 117-120 7755455-8 1994 Intracellular magnesium concentration, calculated from the P-31 NMR spectra, was 277 +/- 17 microM in the untreated hypertensive group, 311 +/- 15 microM in the nitrendipine group and 401 +/- 17 microM in the perindopril group (p < 0.001 versus untreated and nitrendipine). Magnesium 14-23 ATPase H+ transporting V1 subunit E1 Rattus norvegicus 59-63 7755455-10 1994 P-31 NMR spectroscopy demonstrates an increase in myocardial free intracellular magnesium concentration following chronic administration of an angiotensin-converting enzyme inhibitor, perindopril, spontaneously hypertensive rats. Magnesium 80-89 ATPase H+ transporting V1 subunit E1 Rattus norvegicus 0-4 7814849-7 1994 CONCLUSIONS: These three models of experimental hypertension have clearly demonstrated three separate patterns in the regulation of renal and intestinal calbindin-D, which relate to different alterations of factors involved in calcium and magnesium metabolism. Magnesium 239-248 calbindin 1 Rattus norvegicus 153-162 8206564-8 1994 After treatment, intracellular potassium and magnesium were both associated with higher serum insulin (P < .001 for each), and serum potassium was associated with higher and serum magnesium with lower serum glucose (P < .01 for each). Magnesium 45-54 insulin Homo sapiens 94-101 8034651-7 1994 In contrast to ARF proteins, the Arl3 protein has reduced dependence on phospholipids and magnesium for guanine nucleotide exchange. Magnesium 90-99 ADP ribosylation factor like GTPase 3 Homo sapiens 33-37 7965011-9 1994 When magnesium was omitted from the electrode solution, the inward rectification of GCl(V) was unchanged, but the maximum amplitude of GCl(V) increased by a factor of 1.7. Magnesium 5-14 germ cell-less 1, spermatogenesis associated Rattus norvegicus 84-87 7965011-9 1994 When magnesium was omitted from the electrode solution, the inward rectification of GCl(V) was unchanged, but the maximum amplitude of GCl(V) increased by a factor of 1.7. Magnesium 5-14 germ cell-less 1, spermatogenesis associated Rattus norvegicus 135-138 8200955-8 1994 In conclusion, a 4-week magnesium supplementation improves insulin sensitivity and glucose oxidation in the course of a euglycemic-hyperinsulinemic glucose clamp in noninsulin-dependent diabetic patients. Magnesium 24-33 insulin Homo sapiens 59-66 8200345-0 1994 Calcium and magnesium binding to rat parvalbumin. Magnesium 12-21 parvalbumin Rattus norvegicus 37-48 8167340-3 1994 In gel-filtered platelets (GFP) incubated with various additions, the blockade or absence of GPIIb-IIIa resulted in reduced A23187-induced secretion and TxB2 formation in media containing 1 mmol/L Ca2+ with or without fibrinogen and 1 mmol/L Mg2+ plus fibrinogen, but not when Ca, Mg-free buffer alone, 1 mmol/L EDTA, or fibrinogen alone were present. Magnesium 242-244 integrin subunit alpha 2b Homo sapiens 93-98 8074852-0 1994 Effects of parathyroid hormone and parathyroid hormone-related protein on the rates of absorption of magnesium, calcium, sodium, potassium and phosphate ions from the reticulo-rumen of sheep. Magnesium 101-110 parathyroid hormone Ovis aries 35-54 8041342-4 1994 Analysis of both EAMG and MG has revealed that the effector agents in this autoimmune disease are anti-AChR antibodies, whose production is regulated by anti-AChR CD4+ T cells. Magnesium 19-21 CD4 molecule Homo sapiens 163-166 8054262-0 1994 Stimulation of phospholipase A2 activity in mitochondria by magnesium and polyamines. Magnesium 60-69 phospholipase A2 group IB Rattus norvegicus 15-31 8173140-1 1994 OBJECTIVE: To review the methods and summarize the findings of clinical trials evaluating the use of intravenous magnesium (Mg2+) in acute myocardial infarction (AMI); to discuss serum Mg2+ in AMI and the potential mechanisms by which intravenous Mg2+ may be effective. Magnesium 113-122 mucin 7, secreted Homo sapiens 124-127 8112315-7 1994 Since no functional assay for GTP-binding-protein activity in plants is available yet, GTP-binding-protein activation by fluoride and magnesium was deduced from competition with binding of [gamma-35S]GTP[S] to purified plasma membranes. Magnesium 134-143 hydroxycarboxylic acid receptor 3 Homo sapiens 30-49 8112315-7 1994 Since no functional assay for GTP-binding-protein activity in plants is available yet, GTP-binding-protein activation by fluoride and magnesium was deduced from competition with binding of [gamma-35S]GTP[S] to purified plasma membranes. Magnesium 134-143 hydroxycarboxylic acid receptor 3 Homo sapiens 87-106 7848723-12 1994 Hypothesizing that the ECM-nerve terminal connections responsible for the stretch effect involve proteins from the integrin family and knowing that many of the integrin-ECM binding interactions occur at sites on the ECM proteins containing the amino acid sequence RGD, we treated preparations with 0 Ca++, 2 mM Mg++ Ringer to reduce integrin binding and then returned the muscle to normal Ringer containing 0.1-0.2 mM of a six-amino-acid peptide containing the RGD sequence. Magnesium 311-315 multimerin 1 Homo sapiens 23-26 7848723-12 1994 Hypothesizing that the ECM-nerve terminal connections responsible for the stretch effect involve proteins from the integrin family and knowing that many of the integrin-ECM binding interactions occur at sites on the ECM proteins containing the amino acid sequence RGD, we treated preparations with 0 Ca++, 2 mM Mg++ Ringer to reduce integrin binding and then returned the muscle to normal Ringer containing 0.1-0.2 mM of a six-amino-acid peptide containing the RGD sequence. Magnesium 311-315 multimerin 1 Homo sapiens 169-172 7848723-12 1994 Hypothesizing that the ECM-nerve terminal connections responsible for the stretch effect involve proteins from the integrin family and knowing that many of the integrin-ECM binding interactions occur at sites on the ECM proteins containing the amino acid sequence RGD, we treated preparations with 0 Ca++, 2 mM Mg++ Ringer to reduce integrin binding and then returned the muscle to normal Ringer containing 0.1-0.2 mM of a six-amino-acid peptide containing the RGD sequence. Magnesium 311-315 multimerin 1 Homo sapiens 169-172 7848723-16 1994 However, our findings imply that much or all of the length-dependent modulation of release probability is mediated by an RGD-sensitive integrin-ECM interaction that depends more on external Ca++ than on Mg++. Magnesium 203-207 multimerin 1 Homo sapiens 144-147 7907574-6 1994 Interestingly, when calcium ions were first removed from LFA-1, treatment of lymphocytes with magnesium and manganese ions gave significantly higher levels of conjugation than in the presence of calcium. Magnesium 94-103 integrin subunit alpha L Homo sapiens 57-62 8312420-0 1994 Magnesium and parathyroid hormone changes to magnesium-free dialysate in continuous ambulatory peritoneal dialysis patients. Magnesium 45-54 parathyroid hormone Homo sapiens 14-33 8312420-2 1994 The aim of this study was to evaluate the influence of Mg on parathyroid hormone (PTH). Magnesium 55-57 parathyroid hormone Homo sapiens 61-80 7939382-1 1994 Results from a novel ion selective electrode (ISE) for ionized magnesium (Mg2+) correlate well with atomic absorption spectroscopy on aqueous solutions containing from 0.1-3.0 mmol MgCl2/L. Magnesium 63-72 mucin 7, secreted Homo sapiens 74-77 7939390-1 1994 Mg2+ by ion-selective electrode (ISE) is a direct measure of the reactivity of magnesium ions in plasma, which may be clinically and physiologically more relevant than the concentration of total magnesium. Magnesium 79-88 mucin 7, secreted Homo sapiens 0-3 7939390-6 1994 The general opinion of a conference held in Orlando, Florida in March of 1993 was to define free Mg2+ in plasma as the concentration of magnesium in a saline standard with the same magnesium activity as the sample, and report it in SI units (mmol/L). Magnesium 136-145 mucin 7, secreted Homo sapiens 97-100 8091358-2 1994 Insulin secretion requires magnesium: magnesium deficiency results in impaired insulin secretion while magnesium replacement restores insulin secretion. Magnesium 27-36 insulin Homo sapiens 0-7 8091358-2 1994 Insulin secretion requires magnesium: magnesium deficiency results in impaired insulin secretion while magnesium replacement restores insulin secretion. Magnesium 38-47 insulin Homo sapiens 0-7 8091358-2 1994 Insulin secretion requires magnesium: magnesium deficiency results in impaired insulin secretion while magnesium replacement restores insulin secretion. Magnesium 38-47 insulin Homo sapiens 0-7 8091358-3 1994 Furthermore, experimental magnesium deficiency reduces the tissues sensitivity to insulin. Magnesium 26-35 insulin Homo sapiens 82-89 8091358-6 1994 In type 2, or non-insulin-dependent, diabetes mellitus, magnesium deficiency seems to be associated with insulin resistance. Magnesium 56-65 insulin Homo sapiens 18-25 8091358-6 1994 In type 2, or non-insulin-dependent, diabetes mellitus, magnesium deficiency seems to be associated with insulin resistance. Magnesium 56-65 insulin Homo sapiens 105-112 8177242-0 1993 Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency. Magnesium 60-69 tumor necrosis factor Rattus norvegicus 14-41 8177242-2 1993 After two weeks on a Mg-deficient diet, rats show an increase in circulating levels of tumor necrosis factor-alpha and interleukin 1. Magnesium 21-23 tumor necrosis factor Rattus norvegicus 87-114 8241192-0 1993 Role of phosphate-magnesium-binding regions in the high GTPase activity of rac1 protein. Magnesium 18-27 Rac family small GTPase 1 Homo sapiens 75-79 8155482-0 1993 Further study on the magnesium-mediated change in physical state of phospholipid modulates mitochondrial F0-F1-ATPase activity. Magnesium 21-30 ATP synthase F1 subunit epsilon Homo sapiens 105-117 8155482-1 1993 We have postulated that magnesium may play a role in altering the lipid fluidity of the bilayers, which would induce a change of conformation of the F0-ATPase portion (buried in the lipid core) of mitochondrial F0-F1-ATPase. Magnesium 24-33 ATP synthase F1 subunit epsilon Homo sapiens 211-223 8155490-8 1993 Primary magnesium depletion is due to dysregulation of factors controlling magnesium status: intestinal magnesium hypoabsorption, reduced magnesium bone uptake and mobilization, sometimes urinary leakage, hyperadrenoglucocorticism by decreased adaptability to stress, insulin resistance and adrenergic hyporeceptivity. Magnesium 8-17 insulin Homo sapiens 268-275 8155490-13 1993 The importance of magnesium deficit in the aetiologies of insulin resistance, and the adrenergic, osseous, oncogenic, immune and oxidant disturbances of ageing is still uncertain. Magnesium 18-27 insulin Homo sapiens 58-65 8130117-12 1993 Active placental transport of magnesium, but not phosphate, was also shown to be enhanced by PTHrP. Magnesium 30-39 parathyroid hormone like hormone Homo sapiens 93-98 8247134-3 1993 Here we overproduce the RAD2-encoded protein in S. cerevisiae, purify it to near homogeneity, and show that RAD2 protein in the presence of magnesium degrades circular single-stranded DNA. Magnesium 140-149 ssDNA endodeoxyribonuclease RAD2 Saccharomyces cerevisiae S288C 24-28 8247134-3 1993 Here we overproduce the RAD2-encoded protein in S. cerevisiae, purify it to near homogeneity, and show that RAD2 protein in the presence of magnesium degrades circular single-stranded DNA. Magnesium 140-149 ssDNA endodeoxyribonuclease RAD2 Saccharomyces cerevisiae S288C 108-112 8243472-5 1993 The best estimate of the apparent Km, 1.59 +/- 0.23 microM, for the binding of Mg(2+)-thiamin diphosphate to transketolase was obtained in the presence of a high non-inhibitory concentration of magnesium and varied concentrations of thiamin diphosphate. Magnesium 194-203 transketolase Homo sapiens 109-122 10008035-0 1993 Optical properties of Mg-based II-VI ternaries and quaternaries: Cd1-xMgxTe and Cd1-x-yMgxMnyTe. Magnesium 22-24 CD1c molecule Homo sapiens 65-68 10008035-0 1993 Optical properties of Mg-based II-VI ternaries and quaternaries: Cd1-xMgxTe and Cd1-x-yMgxMnyTe. Magnesium 22-24 CD1c molecule Homo sapiens 80-83 8305165-4 1993 Insulin infusion per se stimulated erythrocyte magnesium (1.83 +/- 0.04 v 1.98 +/- 0.03 mmol/L, P < .03) and calcium (4.7 +/- 0.3 v 6.2 +/- 0.4 mumol/L, P < .02) accumulation, and enhanced total body glucose disposal oxidative and nonoxidative glucose metabolisms. Magnesium 47-56 insulin Homo sapiens 0-7 8223626-6 1993 Processed rab6p in low and high magnesium solutions displays similar koff values for GTP and GDP. Magnesium 32-41 RAB6A, member RAS oncogene family Homo sapiens 10-15 8223626-7 1993 However, unprocessed rab6p has a koff value higher for GDP than for GTP in both low and high magnesium solutions. Magnesium 93-102 RAB6A, member RAS oncogene family Homo sapiens 21-26 8240325-4 1993 The GDI protein inhibited carboxyl methylation of G25K in the presence of magnesium and GDP. Magnesium 74-83 cell division cycle 42 Homo sapiens 50-54 8399369-4 1993 Hearts perfused with 0.3 mM, instead of 1.2 mM, [Mg2+]o exhibited significant reductions in [ATP], [PCr], intracellular free Mg ([Mg2+]i), and pHi; a marked rise in intracellular Pi corresponding to a precipitous fall in the cytosolic phosphorylation potential was seen. Magnesium 49-51 glucose-6-phosphate isomerase Rattus norvegicus 143-146 8206589-0 1994 Dietary magnesium prevents fructose-induced insulin insensitivity in rats. Magnesium 8-17 insulin Homo sapiens 44-51 8206589-2 1994 It is possible that the reduced magnesium content of the high-fructose commercial diet used in some studies may play a role in these abnormalities because it is known that magnesium deficiency can produce insulin insensitivity and increased angiotensin II action in humans. Magnesium 32-41 insulin Homo sapiens 205-212 8206589-2 1994 It is possible that the reduced magnesium content of the high-fructose commercial diet used in some studies may play a role in these abnormalities because it is known that magnesium deficiency can produce insulin insensitivity and increased angiotensin II action in humans. Magnesium 32-41 angiotensinogen Homo sapiens 241-255 8206589-2 1994 It is possible that the reduced magnesium content of the high-fructose commercial diet used in some studies may play a role in these abnormalities because it is known that magnesium deficiency can produce insulin insensitivity and increased angiotensin II action in humans. Magnesium 172-181 insulin Homo sapiens 205-212 8206589-2 1994 It is possible that the reduced magnesium content of the high-fructose commercial diet used in some studies may play a role in these abnormalities because it is known that magnesium deficiency can produce insulin insensitivity and increased angiotensin II action in humans. Magnesium 172-181 angiotensinogen Homo sapiens 241-255 8206589-9 1994 Blood pressure and fasting insulin levels were also lower in the magnesium-supplemented group. Magnesium 65-74 insulin Homo sapiens 27-34 8206589-10 1994 These results suggest that magnesium deficiency and not fructose ingestion per se leads to insulin insensitivity in skeletal muscle and changes in blood pressure. Magnesium 27-36 insulin Homo sapiens 91-98 8146594-4 1994 The LXA4 and fMLP responses increased with the PMN concentration, depended on the fetal calf serum concentration, incubation temperature and duration and the presence of calcium and magnesium ions. Magnesium 182-191 formyl peptide receptor 1 Homo sapiens 13-17 8117720-2 1994 Like p-nitrophenyl phosphate (pNPP), ANPP is hydrolyzed by the enzyme only in the presence of calcium and magnesium (K0.5 and Vmax are 0.3 mM and 60 nmol mg-1 min-1, respectively). Magnesium 106-115 CD59 molecule (CD59 blood group) Homo sapiens 159-164 8119992-0 1994 Effects of calcium, magnesium, and phosphorylcholine on secondary structures of human C-reactive protein and serum amyloid P component observed by infrared spectroscopy. Magnesium 20-29 C-reactive protein Homo sapiens 86-104 8119992-4 1994 The CRP spectrum was also affected by magnesium, but the changes differed from those induced by calcium. Magnesium 38-47 C-reactive protein Homo sapiens 4-7 8119138-9 1994 Incubation in glycine-free and high magnesium medium abolished the action of NMDA on GnRH release. Magnesium 36-45 gonadotropin releasing hormone 1 Mus musculus 85-89 8054257-2 1994 It is known that magnesium deficiency or hypomagnesaemia induces hyperinsulinism, while hypermagnesaemia inhibits insulin secretion: however, the mechanism controlling the intracellular level of free magnesium and its role in the insulin-secretory mechanism of pancreatic beta cells (RIN m5F cells) are still unclear. Magnesium 17-26 insulin Homo sapiens 70-77 8054257-3 1994 Using a fluorescent indicator (mag-fura-2) we have found that the influx of magnesium appears to be voltage-dependent and is sensitive to blockade of the voltage-dependent calcium channel in RIN m5F cells; the efflux of magnesium appears to be voltage- and cyclic AMP-independent. Magnesium 76-85 calcium voltage-gated channel subunit alpha1 I Rattus norvegicus 154-187 8054257-5 1994 This finding has led us to speculate on two possible mechanisms through which extracellular magnesium participates in the regulation of insulin secretion: (1) extracellular magnesium may regulate ATP-sensitive potassium channels, and (2) extracellular magnesium may act as a competitive inhibitor of the calcium influx mediated through the voltage-dependent calcium channel. Magnesium 92-101 calcium voltage-gated channel subunit alpha1 I Rattus norvegicus 340-373 8054257-7 1994 Elucidation of the role of magnesium in the insulin secretory mechanism will be beneficial for understanding the insulin secretory mechanism of pancreatic beta cells and may be helpful in treating insulin-related abnormalities in patients with hypo- or hypermagnesaemia. Magnesium 27-36 insulin Homo sapiens 44-51 8054257-7 1994 Elucidation of the role of magnesium in the insulin secretory mechanism will be beneficial for understanding the insulin secretory mechanism of pancreatic beta cells and may be helpful in treating insulin-related abnormalities in patients with hypo- or hypermagnesaemia. Magnesium 27-36 insulin Homo sapiens 113-120 8054257-7 1994 Elucidation of the role of magnesium in the insulin secretory mechanism will be beneficial for understanding the insulin secretory mechanism of pancreatic beta cells and may be helpful in treating insulin-related abnormalities in patients with hypo- or hypermagnesaemia. Magnesium 27-36 insulin Homo sapiens 113-120 8128185-6 1994 Similar to target-binding of untreated LAK cells, the binding between IL-6-treated LAK cells and target cells is dependent on Mg++. Magnesium 126-130 interleukin 6 Homo sapiens 70-74 8307965-0 1994 Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. Magnesium 63-72 sphingomyelin phosphodiesterase 2 Homo sapiens 86-110 7638042-3 1994 Of the greatest importance is the direct influence of Mg2+ on the cardiomyocyte which includes: reduction of cytoplasmatic calcium overload, protection of mitochondria against calcium influx, and diminution of cellular potassium, magnesium and ATP depletion. Magnesium 230-239 mucin 7, secreted Homo sapiens 54-57 7512305-5 1994 When MG-63 cells were treated for 30 minutes with parathyroid hormone (PTH), the levels of tyrosine phosphorylation of c-src were increased in comparison with the untreated control. Magnesium 5-7 parathyroid hormone Homo sapiens 50-69 7512305-5 1994 When MG-63 cells were treated for 30 minutes with parathyroid hormone (PTH), the levels of tyrosine phosphorylation of c-src were increased in comparison with the untreated control. Magnesium 5-7 parathyroid hormone Homo sapiens 71-74 7512305-5 1994 When MG-63 cells were treated for 30 minutes with parathyroid hormone (PTH), the levels of tyrosine phosphorylation of c-src were increased in comparison with the untreated control. Magnesium 5-7 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 119-124 8202305-5 1993 These observations suggest that the synthesis of parathyroid hormone may be stimulated in the parathyroid glands of magnesium-treated hamsters exposed to hypergravity environment. Magnesium 116-125 parathyroid hormone Mesocricetus auratus 49-68 12271059-5 1993 One of these complexes was identified as an association of the Rieske protein with the chaperonin Cpn60 complex by its electrophoretic mobility, Mg-ATP-dependent dissociation, and immunoprecipitation with anti-Cpn60 antibodies. Magnesium 145-147 heat shock protein family D (Hsp60) member 1 Homo sapiens 98-103 12271059-5 1993 One of these complexes was identified as an association of the Rieske protein with the chaperonin Cpn60 complex by its electrophoretic mobility, Mg-ATP-dependent dissociation, and immunoprecipitation with anti-Cpn60 antibodies. Magnesium 145-147 heat shock protein family D (Hsp60) member 1 Homo sapiens 210-215 8250951-1 1993 The effects of extracellular magnesium concentration ([Mg2+]ex) on thyrotropin-releasing hormone (TRH)-stimulated intracellular free calcium mobilization and prolactin secretion were investigated concomitantly with measurement of the intracellular free magnesium concentration ([Mg2+]i). Magnesium 29-38 thyrotropin releasing hormone Rattus norvegicus 67-96 8250951-1 1993 The effects of extracellular magnesium concentration ([Mg2+]ex) on thyrotropin-releasing hormone (TRH)-stimulated intracellular free calcium mobilization and prolactin secretion were investigated concomitantly with measurement of the intracellular free magnesium concentration ([Mg2+]i). Magnesium 29-38 thyrotropin releasing hormone Rattus norvegicus 98-101 8054262-1 1994 Endogenous phospholipase A2 activity in hypotonically swollen, non-respiring rat liver mitochondria was found to be stimulated by 1-10 mM magnesium and by 0.5-1.2 mM of the polyamines spermine and spermidine in the absence of added calcium. Magnesium 138-147 phospholipase A2 group IB Rattus norvegicus 11-27 8054263-3 1994 In nine other patients treated with HEP + B1,B6 + magnesium, ETK-AC and Km TPP were both significantly decreased. Magnesium 50-59 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 42-47 8399235-9 1993 The decay of the triplet-state (ZnP)CcP or magnesium-substituted CcP [(MgP)CcP] was examined during titrations with Fe3+Cc to determine limits for the dissociation rate constant (koff) for the complex. Magnesium 43-52 matrix Gla protein Equus caballus 71-74 8242233-7 1993 If 1 mM GDP was in the pipette but Mg ions were omitted the effect of GDP was absent and IK(Ckm) averaged only 10 pA, suggesting that the action of (-)-Ckm was Mg-dependent. Magnesium 160-162 creatine kinase M-type Oryctolagus cuniculus 152-155 8228558-0 1993 Effects of magnesium on the renin-angiotensin-aldosterone system in human subjects. Magnesium 11-20 renin Homo sapiens 28-33 8228558-2 1993 This study was designed to determine the effect of intravenous administration of magnesium on the renin-angiotensin-aldosterone (RAA) system. Magnesium 81-90 renin Homo sapiens 98-103 8228558-10 1993 These data indicate that magnesium stimulates renin release through the elevation of prostaglandins and suppresses aldosterone production through the intracellular calcium mobilization. Magnesium 25-34 renin Homo sapiens 46-51 8117997-0 1993 [The effect of a magnesium-free solution on neuronal activity in the snail]. Magnesium 17-26 snail family transcriptional repressor 1 Homo sapiens 69-74 8117997-1 1993 This investigation has revealed that application of magnesium-free medium to snail brain preparations results in the development of paroxysmal depolarization shifts (PDSs) and depolarizing afterpotentials in some neurons. Magnesium 52-61 snail family transcriptional repressor 1 Homo sapiens 77-82 8117997-6 1993 The results show that the snail brain preparation immersed to the magnesium-free solution is a suitable model of experimental epilepsy, since Helix nerve cells are easy to identify. Magnesium 66-75 snail family transcriptional repressor 1 Homo sapiens 26-31 8292267-5 1993 In the presence of EDTA, the inhibition observed with CS2 in excess Mg++ (3.6m mol.L-1) medium was comparatively much less in both non-reserpinized and reserpinized preparations. Magnesium 68-72 calsyntenin 2 Rattus norvegicus 54-57 7693427-8 1993 Although the mechanism of action of magnesium is likely to be independent of other currently used agents, its value when added to thrombolytic therapy, beta-blockers, angiotensin converting enzyme (ACE) inhibitors and nitrates is not clear, and is presently being studied in the very large Fourth International Studies of Infarct Survival (ISIS-4) trial. Magnesium 36-45 angiotensin I converting enzyme Homo sapiens 167-196 8292494-4 1993 These results support the supposition of a close relationship between Mg and elastin. Magnesium 70-72 elastin Homo sapiens 77-84 8292501-1 1993 This review focuses on the action of intracellular magnesium ion on the inositol 1,4,5-trisphosphate (IP3) receptor, the almost ubiquitous membrane-bound Ca2+ channel gated by the intracellular second messenger IP3. Magnesium 51-60 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 102-115 7692419-6 1993 The sequence of changes suggests that the decrease of potassium and magnesium after ventricular tachycardia was due to a shift of the electrolytes into cells, related to the insulin-mediated movement of glucose from the blood into cells. Magnesium 68-77 insulin Homo sapiens 174-181 8363603-1 1993 It is demonstrated that several HeLa nuclear proteins interact in a magnesium-dependent fashion with a conditionally processed pre-mRNA derived from an alternatively spliced region of the rat fibronectin gene. Magnesium 68-77 fibronectin 1 Rattus norvegicus 192-203 8363603-2 1993 HnRNP C proteins crosslink under both permissive and non-permissive conditions (high and low magnesium, respectively), whereas hnRNP I/PTB is observed only under the latter. Magnesium 93-102 heterogeneous nuclear ribonucleoprotein C Rattus norvegicus 0-7 8408083-0 1993 The subunit location of magnesium in cytochrome c oxidase. Magnesium 24-33 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 37-57 8408083-1 1993 The magnesium ion in bovine heart cytochrome c oxidase can be depleted up to 75% by heat treatment of the enzyme at 43 degrees C followed by dialysis against EDTA buffer solution. Magnesium 4-13 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 34-54 8408083-3 1993 This is the first attempt to deplete magnesium ion from bovine heart cytochrome c oxidase without denaturation of the protein. Magnesium 37-46 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 69-89 8405745-0 1993 Intracellular and extracellular magnesium depletion in type 2 (non-insulin-dependent) diabetes mellitus. Magnesium 32-41 insulin Homo sapiens 67-74 8243023-2 1993 It was found that a diabetic condition is apt to bring about marked changes in body magnesium content and its compartmental distribution, and that the administration of dietary magnesium supplements can have a favorable influence on metabolic control, thus reducing insulin requirement and counteracting the progression of late diabetic complications. Magnesium 177-186 insulin Homo sapiens 266-273 8333439-0 1993 Magnesium sulfate inhibits oxytocin-induced calcium mobilization in human puerperal myometrial cells: possible involvement of intracellular free magnesium concentration. Magnesium 145-154 oxytocin/neurophysin I prepropeptide Homo sapiens 27-35 8396158-1 1993 It has been reported that the urinary excretions of chloride (Cl), potassium (K), and magnesium (Mg), but not sodium (Na), after furosemide, a loop diuretic, were decreased by pretreatment with lisinopril, an ACE inhibitor in hypertensive subjects. Magnesium 86-95 angiotensin I converting enzyme Homo sapiens 209-212 8396158-1 1993 It has been reported that the urinary excretions of chloride (Cl), potassium (K), and magnesium (Mg), but not sodium (Na), after furosemide, a loop diuretic, were decreased by pretreatment with lisinopril, an ACE inhibitor in hypertensive subjects. Magnesium 97-99 angiotensin I converting enzyme Homo sapiens 209-212 8358532-1 1993 Interaction of ionized magnesium ([Mg2+]o) and caffeine in regulation of intracellular free calcium concentration ([Ca2+]i) in human aortic endothelial cells was studied using fura-2 and digital imaging microscopy. Magnesium 23-32 carbonic anhydrase 2 Homo sapiens 116-119 8515467-3 1993 The results from experiments that distinguish multiple structures forming in a given plasmid DNA population strongly suggest that polyd(GA).polyd(CT) sequences of 33 base-pairs or more can adopt both H-y3 and H-y5 isomeric forms of H-DNA at neutral pH either with or without magnesium ions. Magnesium 275-284 RNA, Ro60-associated Y3 Homo sapiens 200-204 8509403-2 1993 This autophosphorylation activity did not occur in the presence of magnesium but had the same pH optimum as reported for its magnesium-dependent ATPase activity. Magnesium 67-76 dynein axonemal heavy chain 8 Homo sapiens 145-151 7685580-0 1993 The role of divalent magnesium in activating the reaction catalyzed by orotate phosphoribosyltransferase. Magnesium 21-30 uridine monophosphate synthetase Homo sapiens 71-104 7685580-4 1993 In this work we chose to explore the role of divalent magnesium in activating the phosphoribosyl transfer in bacterial OPRTase. Magnesium 54-63 uridine monophosphate synthetase Homo sapiens 119-126 8505087-4 1993 The magnesium infusion reduced urinary thromboxane concentration and angiotensin II-induced plasma aldosterone levels. Magnesium 4-13 angiotensinogen Homo sapiens 69-83 8505087-7 1993 Similarly, angiotensin II-induced plasma aldosterone concentration increased after magnesium deficiency. Magnesium 83-92 angiotensinogen Homo sapiens 11-25 8505087-8 1993 Analysis showed that all subjects studied had a decrease in insulin sensitivity after magnesium deficiency (3.69 +/- 0.6 to 2.75 +/- 0.5 min-1 per microunit per milliliter x 10(-4), p < 0.03). Magnesium 86-95 insulin Homo sapiens 60-67 8505087-10 1993 These effects are associated with a decrease in insulin action, suggesting that magnesium deficiency may be a common factor associated with insulin resistance and vascular disease. Magnesium 80-89 insulin Homo sapiens 48-55 8505087-10 1993 These effects are associated with a decrease in insulin action, suggesting that magnesium deficiency may be a common factor associated with insulin resistance and vascular disease. Magnesium 80-89 insulin Homo sapiens 140-147 8400511-5 1993 The magnesium supplement immediately relieved the tetany, and induced striking increases in both intact and mid-region PTH levels transiently and continuous elevations of osteocalcin levels. Magnesium 4-13 bone gamma-carboxyglutamate protein Homo sapiens 171-182 8505087-0 1993 Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Magnesium 0-9 insulin Homo sapiens 30-37 7506049-7 1993 Compared to warm re-exposed control rats, CmH+ was threefold higher in the corresponding Mg-deficient group which indicated a much lower masking of the proton channel of UCP with the Mg-deficient diet. Magnesium 89-91 uncoupling protein 1 Rattus norvegicus 170-173 7506049-7 1993 Compared to warm re-exposed control rats, CmH+ was threefold higher in the corresponding Mg-deficient group which indicated a much lower masking of the proton channel of UCP with the Mg-deficient diet. Magnesium 183-185 uncoupling protein 1 Rattus norvegicus 170-173 8225454-4 1993 The hyperglycemia in these cases was inversely related to hypomagnesemia and its restoration towards normal by insulin therapy restored the normal serum magnesium concentration. Magnesium 153-162 insulin Homo sapiens 111-118 8390527-0 1993 The effect of angiotensin II on platelet intracellular free magnesium and calcium ionic concentrations in essential hypertension. Magnesium 60-69 angiotensinogen Homo sapiens 14-28 8390527-13 1993 CONCLUSIONS: These data demonstrate a relationship between angiotensin II and intracellular magnesium and calcium. Magnesium 92-101 angiotensinogen Homo sapiens 59-73 8390527-14 1993 In hypertension, angiotensin II-stimulated calcium responses may be related to simultaneously decreased intracellular magnesium concentrations. Magnesium 118-127 angiotensinogen Homo sapiens 17-31 8225541-0 1993 Magnesium and reserpine influence norepinephrine sensitivity of vas deferens in rats. Magnesium 0-9 arginine vasopressin Rattus norvegicus 64-67 8225541-2 1993 Vas deferens incubated in Mg++ free and Mg++ excess media showed supersensitivity and subsensivity to NE respectively. Magnesium 26-30 arginine vasopressin Rattus norvegicus 0-3 8225541-4 1993 In the presence of EDTA, vas deferens obtained from reserpinized animals showed subsensitivity in normal and Mg++ excess media and supersensitivity in Mg++ free medium. Magnesium 109-113 arginine vasopressin Rattus norvegicus 25-28 8225541-4 1993 In the presence of EDTA, vas deferens obtained from reserpinized animals showed subsensitivity in normal and Mg++ excess media and supersensitivity in Mg++ free medium. Magnesium 151-155 arginine vasopressin Rattus norvegicus 25-28 8095961-7 1993 This increased adhesion was found to require an intact cytoskeleton, to be energy and magnesium dependent, and could be completely inhibited by anti-LFA-1 and anti-ICAM-1. Magnesium 86-95 integrin subunit alpha L Homo sapiens 149-154 8385143-5 1993 However, Mg ions in SBF slow down formation of the a-CaP layer and greatly retard crystallization of HCAp on the glass surface. Magnesium 9-11 HCA1 Homo sapiens 101-105 8095961-7 1993 This increased adhesion was found to require an intact cytoskeleton, to be energy and magnesium dependent, and could be completely inhibited by anti-LFA-1 and anti-ICAM-1. Magnesium 86-95 intercellular adhesion molecule 1 Homo sapiens 164-170 8460675-2 1993 In another group of Mg-deficient animals chloroquine treatment diminished significantly the levels of circulating cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) and also resulted in a major decrease in myocardial lesions. Magnesium 20-22 interleukin 6 Rattus norvegicus 140-153 8460675-2 1993 In another group of Mg-deficient animals chloroquine treatment diminished significantly the levels of circulating cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) and also resulted in a major decrease in myocardial lesions. Magnesium 20-22 tumor necrosis factor Rattus norvegicus 159-186 8485230-3 1993 Subunits Gi2 alpha and GS alpha (but not beta 1 or SMG-proteins) my partially (approximately 1%) dissociate from the membrane by the action of the GTP analogs GTP[S] or Gpp(NH)p in the presence of magnesium ions. Magnesium 197-206 GNAS complex locus Homo sapiens 23-31 8467315-6 1993 Magnesium in saliva appeared reduced in ACEI-treated hypertensives (0.28 +/- 0.06 mmol/l) in comparison to the similar values of normotensives (0.53 +/- 0.05) and Ca-ANT treated hypertensives (0.54 +/- 0.07). Magnesium 0-9 solute carrier family 25 member 6 Homo sapiens 166-169 8445010-0 1993 Insulin increases intracellular magnesium transport in human platelets. Magnesium 32-41 insulin Homo sapiens 0-7 8445010-9 1993 Furthermore, the insulin-stimulated Mg transport was inhibited by the addition of chelating agent ethylenediaminete-traacetate while the receptor binding was not altered. Magnesium 36-38 insulin Homo sapiens 17-24 8445010-10 1993 These findings suggest that insulin can translocate Mg from the extracellular space. Magnesium 52-54 insulin Homo sapiens 28-35 8479006-8 1993 However, after oral treatment of six cystinuric dogs with 2-MPG for 2-4 months, significantly increased excretions of Ca and Mg were found. Magnesium 125-127 N-methylpurine DNA glycosylase Canis lupus familiaris 60-63 8436225-3 1993 Results indicated that AChR-specific antibodies purified from MG patient serum by binding to and elution from antigen columns were found to inhibit Ca(2+)-dependent, myosin-associated ATPase activity; interestingly, this inhibition appeared to be relatively selective in that neither K+(EDTA)-dependent nor Mg(2+)-dependent ATPase activities were sensitive to antibody-mediated interference. Magnesium 307-309 myosin heavy chain 14 Homo sapiens 166-172 8436225-3 1993 Results indicated that AChR-specific antibodies purified from MG patient serum by binding to and elution from antigen columns were found to inhibit Ca(2+)-dependent, myosin-associated ATPase activity; interestingly, this inhibition appeared to be relatively selective in that neither K+(EDTA)-dependent nor Mg(2+)-dependent ATPase activities were sensitive to antibody-mediated interference. Magnesium 307-309 dynein axonemal heavy chain 8 Homo sapiens 184-190 8095405-2 1993 Two forms of parvalbumin, i.e., the fully Ca-loaded form PaCa2 and the fully Mg-loaded form PaMg2, are investigated by 2D 1H NMR in solution. Magnesium 77-79 parvalbumin Homo sapiens 13-24 8430677-2 1993 Controversy remains regarding the role of decreased magnesium in producing impaired parathyroid hormone (PTH) secretion versus target organ unresponsiveness to PTH. Magnesium 52-61 parathyroid hormone Homo sapiens 84-103 7679645-4 1993 However, pretreatment of lymphocytes with anti-CD44 resulted in the rapid appearance of Ca(2+)-, Mg(2+)-independent, LFA-1/ICAM-1-, CD2/LFA-3, VLA-4/VCAM-1-independent lymphocyte binding, indicating that a novel adhesion pathway was induced by the anti-CD44 treatment. Magnesium 97-99 CD44 antigen Mus musculus 47-51 12231782-8 1993 PEPC was shown to be activated in a time-dependent manner when desalted soybean nodule extracts were preincubated with Mg.ATP in vitro. Magnesium 119-121 phosphoenolpyruvate carboxylase, housekeeping isozyme Glycine max 0-4 12231782-13 1993 The antiserum against soybean nodule PEPC was used to immunoprecipitate PEPC from a desalted nodule extract that had been preincubated with Mg.[[gamma]-32P]ATP. Magnesium 140-142 phosphoenolpyruvate carboxylase, housekeeping isozyme Glycine max 37-41 12231782-13 1993 The antiserum against soybean nodule PEPC was used to immunoprecipitate PEPC from a desalted nodule extract that had been preincubated with Mg.[[gamma]-32P]ATP. Magnesium 140-142 phosphoenolpyruvate carboxylase, housekeeping isozyme Glycine max 72-76 8470943-0 1993 Effectiveness of calcium and magnesium on testicular sulfatase activity. Magnesium 29-38 arylsulfatase family member H Homo sapiens 53-62 8478786-4 1993 Plasma membrane (surface) CD11b as measured by flow cytometry was found to be reduced with time when cells (PB-PMNs or CF-PMNs) from either controls or patients were treated with calcium- and magnesium-free buffer. Magnesium 192-201 integrin subunit alpha M Homo sapiens 26-31 8478786-5 1993 However, when CF-PMNs were treated with buffer containing Ca++/Mg++, surface CD11b expression increased on cells from both controls and patients. Magnesium 63-67 integrin subunit alpha M Homo sapiens 77-82 8465449-1 1993 At present, magnesium treatment is employed routinely in the treatment of hypertension induced by pregnancy (PIH) and preeclampsia in USA with the object of preventing seizures. Magnesium 12-21 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 109-112 8458528-1 1993 Elevated erythrocyte cytosolic free calcium, and suppressed free magnesium and pH values are associated with the hyperinsulinaemia and insulin resistance of hypertension, obesity, and Type 2 (non-insulin-dependent) diabetes mellitus. Magnesium 65-74 insulin Homo sapiens 118-125 8458528-6 1993 Similarly, insulin also increased intracellular free magnesium at all time points (basal: 177 +/- 11 mumol/l; 60 min: 209 +/- 19 mumol/l; 120 min: 206 +/- 22 mumol/l; and 180 min: 202 +/- 12 mumol/l; p < 0.05 vs basal at all times). Magnesium 53-62 insulin Homo sapiens 11-18 8441610-5 1993 Neither 5" capping, nor polyadenylation of the substrate mRNAs affects their degradation by the IL2-selective mRNase, whose activity is optimal in 0.5 mM Mg++ and 100 mM potassium acetate. Magnesium 154-158 interleukin 2 Homo sapiens 96-99 8472612-4 1993 Interestingly, when the cell staining was performed in the presence of calcium and magnesium, we observed a significant increase of CD45 and an equivalent decrease of IgE cell surface expression, as well as an IgE concentration dependent diminution of the number of CD45dim-IgEbright cells. Magnesium 83-92 protein tyrosine phosphatase receptor type C Homo sapiens 132-136 8472612-4 1993 Interestingly, when the cell staining was performed in the presence of calcium and magnesium, we observed a significant increase of CD45 and an equivalent decrease of IgE cell surface expression, as well as an IgE concentration dependent diminution of the number of CD45dim-IgEbright cells. Magnesium 83-92 protein tyrosine phosphatase receptor type C Homo sapiens 266-270 8112724-6 1993 Calcitriol levels were significantly higher and magnesium levels slightly lower in the SCC group than those in the MM group. Magnesium 48-57 serpin family B member 3 Homo sapiens 87-90 8428707-5 1993 Parathyroid hormone levels markedly dropped in the 60th minute of hypermagnesemia duration (p < 0.01), the drop depending on the initial values of the hormone prior to the administration of magnesium (r = 0.923, p < 0.01). Magnesium 193-202 parathyroid hormone Homo sapiens 0-19 8421063-11 1993 The binding was Ca+2/Mg+2 ion dependent and inhibited with fluid phase TSP and anti-CBP. Magnesium 21-24 thrombospondin 1 Homo sapiens 71-74 8421063-11 1993 The binding was Ca+2/Mg+2 ion dependent and inhibited with fluid phase TSP and anti-CBP. Magnesium 21-24 CREB binding protein Homo sapiens 84-87 8264508-4 1993 In the cTAL, up to six hormones (including PTH) or agonists can stimulate Mg transport. Magnesium 74-76 parathyroid hormone Mus musculus 43-46 8382811-7 1993 In addition, metal ions inhibited NT binding and the contractile action of NT with the same order of potency (Hg++ > Zn++ > Cu++ > Mn++ > Mg++ > Li++). Magnesium 150-154 neurotensin/neuromedin N Cavia porcellus 75-77 8212415-0 1993 Relationship between the incidence infection stones and the magnesium-calcium ratio of tap water. Magnesium 60-69 nuclear RNA export factor 1 Homo sapiens 87-90 8212415-1 1993 In a previous study we showed that the magnesium-calcium ratio of tap water is negatively correlated with the incidence of calcium-containing urinary stones. Magnesium 39-48 nuclear RNA export factor 1 Homo sapiens 66-69 8212415-3 1993 The magnesium-calcium ratio of tap water was found to correlate positively with the incidence of struvite stones. Magnesium 4-13 nuclear RNA export factor 1 Homo sapiens 31-34 8212415-4 1993 The tap water magnesium-calcium ratio was high in regions of basalt and sedimentary rock and was low in granite and limestone areas. Magnesium 14-23 nuclear RNA export factor 1 Homo sapiens 4-7 8212415-6 1993 Thus, this study suggested that the incidence of struvite stones is related to the magnesium-calcium ratio of tap water and to the regional geology, as is the case for calcium-containing stones. Magnesium 83-92 nuclear RNA export factor 1 Homo sapiens 110-113 1489073-5 1992 The study was performed to analyse the influence of magnesium infusion on the haemodynamic status and plasma renin activity in patients undergoing aortocoronary bypass grafting. Magnesium 52-61 renin Homo sapiens 109-114 1342184-9 1992 The milk of this region is a good source of calcium, magnesium, phosphorus and zinc, with 35%, 7.4%, 19% and 9% respectively of the RDA being obtained from a 237 ml portion of milk. Magnesium 53-62 Weaning weight-maternal milk Bos taurus 4-8 1361894-6 1992 EGF-induced hypocalcaemia was associated with reduced milk calcium secretion and increased urinary calcium excretion whereas EGF-induced hypermagnesaemia was associated with reduced urinary and total magnesium losses. Magnesium 200-209 EGF Ovis aries 125-128 1459129-3 1992 The equation is applied to the magnesium and spermidine dependences of the isoleucyl-tRNA synthetase reaction. Magnesium 31-40 isoleucyl-tRNA synthetase 1 Homo sapiens 75-100 1296767-0 1992 Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms. Magnesium 14-23 colony stimulating factor 2 Homo sapiens 10-13 1296767-5 1992 CSF concentrations of magnesium are normally higher than magnesium plasma ultrafiltrate (diffusible) concentrations due to the active transport of magnesium across the blood-brain barrier. Magnesium 22-31 colony stimulating factor 2 Homo sapiens 0-3 1296767-6 1992 Under conditions of magnesium deficiency, CSF concentrations decline, although this decline lags behind and is less pronounced than the changes observed in plasma magnesium concentrations. Magnesium 20-29 colony stimulating factor 2 Homo sapiens 42-45 1296767-7 1992 Decreases in CSF magnesium concentrations correlate with the alterations observed in extracellular brain magnesium concentrations in animals following the dietary deprivation of magnesium. Magnesium 17-26 colony stimulating factor 2 Homo sapiens 13-16 1296767-7 1992 Decreases in CSF magnesium concentrations correlate with the alterations observed in extracellular brain magnesium concentrations in animals following the dietary deprivation of magnesium. Magnesium 105-114 colony stimulating factor 2 Homo sapiens 13-16 1479660-1 1992 The muscle contractility and neuromuscular blockade of muscle relaxants are influenced by the electrolytes, especially magnesium ion(Mg2+) and calcium ion(Ca2+), in the extracellular fluid. Magnesium 119-128 mucin 7, secreted Homo sapiens 133-136 1466501-14 1992 Magnesium concentration was lower in CSF, compared with serum. Magnesium 0-9 colony stimulating factor 2 Bos taurus 37-40 1296767-7 1992 Decreases in CSF magnesium concentrations correlate with the alterations observed in extracellular brain magnesium concentrations in animals following the dietary deprivation of magnesium. Magnesium 105-114 colony stimulating factor 2 Homo sapiens 13-16 1296767-8 1992 CSF magnesium concentrations can readily be repleted following magnesium supplementation, although high dose magnesium therapy, such as that used in the treatment of convulsions in eclampsia, will only increase CSF magnesium concentrations to a very limited degree (approximately 11-18 per cent) above physiological concentrations. Magnesium 4-13 colony stimulating factor 2 Homo sapiens 0-3 1296767-8 1992 CSF magnesium concentrations can readily be repleted following magnesium supplementation, although high dose magnesium therapy, such as that used in the treatment of convulsions in eclampsia, will only increase CSF magnesium concentrations to a very limited degree (approximately 11-18 per cent) above physiological concentrations. Magnesium 63-72 colony stimulating factor 2 Homo sapiens 0-3 1296767-8 1992 CSF magnesium concentrations can readily be repleted following magnesium supplementation, although high dose magnesium therapy, such as that used in the treatment of convulsions in eclampsia, will only increase CSF magnesium concentrations to a very limited degree (approximately 11-18 per cent) above physiological concentrations. Magnesium 63-72 colony stimulating factor 2 Homo sapiens 0-3 1296767-8 1992 CSF magnesium concentrations can readily be repleted following magnesium supplementation, although high dose magnesium therapy, such as that used in the treatment of convulsions in eclampsia, will only increase CSF magnesium concentrations to a very limited degree (approximately 11-18 per cent) above physiological concentrations. Magnesium 63-72 colony stimulating factor 2 Homo sapiens 0-3 1296767-9 1992 Greater increases in CSF magnesium may occur in neonates since neonatal swine, following treatment with magnesium, have CSF magnesium concentrations that are similar to their plasma concentrations. Magnesium 25-34 colony stimulating factor 2 Sus scrofa 21-24 1296767-9 1992 Greater increases in CSF magnesium may occur in neonates since neonatal swine, following treatment with magnesium, have CSF magnesium concentrations that are similar to their plasma concentrations. Magnesium 25-34 colony stimulating factor 2 Sus scrofa 120-123 1296767-9 1992 Greater increases in CSF magnesium may occur in neonates since neonatal swine, following treatment with magnesium, have CSF magnesium concentrations that are similar to their plasma concentrations. Magnesium 104-113 colony stimulating factor 2 Sus scrofa 21-24 1296767-9 1992 Greater increases in CSF magnesium may occur in neonates since neonatal swine, following treatment with magnesium, have CSF magnesium concentrations that are similar to their plasma concentrations. Magnesium 104-113 colony stimulating factor 2 Sus scrofa 120-123 1296767-9 1992 Greater increases in CSF magnesium may occur in neonates since neonatal swine, following treatment with magnesium, have CSF magnesium concentrations that are similar to their plasma concentrations. Magnesium 104-113 colony stimulating factor 2 Sus scrofa 21-24 1296767-9 1992 Greater increases in CSF magnesium may occur in neonates since neonatal swine, following treatment with magnesium, have CSF magnesium concentrations that are similar to their plasma concentrations. Magnesium 104-113 colony stimulating factor 2 Sus scrofa 120-123 8264520-1 1993 Abnormal dietary deficiency in Mg as well as abnormalities in Mg metabolism appear to play important roles as risk factors for ischemic heart disease and acute myocardial infarction, namely in hypertensive vascular disease, diabetic vascular disease, insulin resistance, atherosclerosis and vasospasm. Magnesium 62-64 insulin Homo sapiens 251-258 1424126-6 1992 The addition of the metal ion buffer N-hydroxyethylethylenediaminetriacetic acid, along with low concentrations of Zn and Mg, as used in the IFCC/RM/ALP, reduced the slow loss in activity over time, as did decreasing the reaction temperature to 30 degrees C, but had no effect on the early rapid decay in activity seen in the first minute. Magnesium 122-124 alkaline phosphatase, placental Homo sapiens 149-152 1451904-0 1992 Allosteric regulation of rat testis mitochondrial aldehyde dehydrogenase by capronaldehyde and magnesium ion. Magnesium 95-104 aldehyde dehydrogenase 2 family member Rattus norvegicus 36-72 1338597-8 1992 A significant negative correlation existed between the pretreatment PRA and changes in MBP after magnesium supplementation in EH (r = -0.65, p < 0.01), and there was a significant positive correlation between changes in PATPI and changes in MBP as a whole (r = 0.41, p < 0.05). Magnesium 97-106 myelin basic protein Homo sapiens 87-90 1403290-6 1992 Metaphyseal bone osteocalcin levels were reduced in the Mg-deficient rats and lipid was more easily extracted from their bones. Magnesium 56-58 bone gamma-carboxyglutamate protein Rattus norvegicus 17-28 1338597-9 1992 These results support the view that oral magnesium supplementation is a useful approach to treatment of patients with uncomplicated essential hypertension, especially those with high plasmas renin activity. Magnesium 41-50 renin Homo sapiens 191-196 1443440-4 1992 Significant reduction of aspartate-aminotransferase (ASAT), alanine-aminotransferase (ALAT) and gamma-glutamyl-transpeptidase (GGT) were seen after magnesium, whereas no change was observed with placebo. Magnesium 148-157 glutamic--pyruvic transaminase Homo sapiens 60-84 1329339-9 1992 The protein kinase activity associated with VZV ORF 47 had several distinctive biochemical properties: (i) its phosphotransferase activity was enhanced more by manganese than by magnesium, (ii) it utilized both ATP and GTP as donors of phosphate, and (iii) it phosphorylated both acidic and basic substrates. Magnesium 178-187 tegument serine/threonine protein kinase Human alphaherpesvirus 3 48-54 1356833-6 1992 NAAG-induced current in NMDAR1-injected oocytes was potentiated by glycine, dose-dependently antagonized by DL-2-amino-5-phosphonovaleric acid, and blocked by magnesium ions in a voltage-dependent fashion. Magnesium 159-168 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 24-30 1400384-6 1992 At low magnesium ion concentration, both ATP hydrolysis and lexA protein cleavage experiments demonstrate that these recA proteins displace SSB protein from ssDNA in a manner consistent with their in vivo repressor cleavage activity, i.e. recA730 protein > recA441 protein > recA803 protein > recAwt protein. Magnesium 7-16 single-stranded DNA-binding protein Escherichia coli 140-143 1329036-5 1992 Chelation of Mg++ by EDTA and the addition of salt to a high concentration also reverse the double strand DNA cleavage, and like heat reversion, topoisomerase II remains bound to DNA through single strand DNA break. Magnesium 13-17 Topoisomerase 2 Drosophila melanogaster 145-161 1443440-4 1992 Significant reduction of aspartate-aminotransferase (ASAT), alanine-aminotransferase (ALAT) and gamma-glutamyl-transpeptidase (GGT) were seen after magnesium, whereas no change was observed with placebo. Magnesium 148-157 glutamic--pyruvic transaminase Homo sapiens 86-90 1443440-4 1992 Significant reduction of aspartate-aminotransferase (ASAT), alanine-aminotransferase (ALAT) and gamma-glutamyl-transpeptidase (GGT) were seen after magnesium, whereas no change was observed with placebo. Magnesium 148-157 inactive glutathione hydrolase 2 Homo sapiens 96-125 1418829-9 1992 In the multiple linear regression analysis of the pooled basal data (n = 42), erythrocyte magnesium content displayed an independent correlation with basal plasma insulin levels (t = -2.08, P < .05). Magnesium 90-99 insulin Homo sapiens 163-170 1418832-1 1992 A dose-dependent effect of magnesium on the inhibition of platelet aggregation and release of ATP from dense granules was observed in human platelets (in whole blood, platelet-rich plasma, or washed platelets) against various aggregation agents (ADP, U46619, collagen, or thrombin). Magnesium 27-36 coagulation factor II, thrombin Homo sapiens 272-280 1418832-3 1992 These Mg-mediated activities were further enhanced when platelets were preincubated with insulin (100 microU/mL). Magnesium 6-8 insulin Homo sapiens 89-96 1418832-5 1992 Thrombin-stimulated influx of Ca ions decreased from 194 +/- 30 nmol/L to 156 +/- 21 nmol/L in the presence of 5 mmol/L Mg and to 111 +/- 16 nmol/L in 10 mmol/L Mg. Magnesium 120-122 coagulation factor II, thrombin Homo sapiens 0-8 1418832-5 1992 Thrombin-stimulated influx of Ca ions decreased from 194 +/- 30 nmol/L to 156 +/- 21 nmol/L in the presence of 5 mmol/L Mg and to 111 +/- 16 nmol/L in 10 mmol/L Mg. Magnesium 161-163 coagulation factor II, thrombin Homo sapiens 0-8 1418832-10 1992 Furthermore, insulin can potentiate the inhibitory effects of Mg on platelet activation. Magnesium 62-64 insulin Homo sapiens 13-20 1457764-5 1992 Furthermore, for all subjects, free calcium and free magnesium levels were closely related both to the left ventricular mass and to the degree of insulin resistance present. Magnesium 53-62 insulin Homo sapiens 146-153 1415420-1 1992 OBJECTIVE: Our objective was to investigate the possible restoring action of magnesium on vascular sensitivity to angiotensin II in pregnancy. Magnesium 77-86 angiotensinogen Homo sapiens 114-128 1472949-8 1992 IGF-I binding was inhibited by a variety of salts in a dose-dependent manner, calcium and magnesium salts being more effective than sodium or potassium salts. Magnesium 90-99 insulin like growth factor 1 Homo sapiens 0-5 1382314-3 1992 In the NR1 subunit, replacement of this asparagine by a glutamine residue decreases calcium permeability of the channel and slightly reduces magnesium block. Magnesium 141-150 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 7-10 1384353-1 1992 During the progression of Mg deficiency in a rodent model, we have observed dramatic increases in serum levels of inflammatory cytokines [interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] after 3 wk on a Mg-deficient diet. Magnesium 26-28 interleukin 6 Rattus norvegicus 160-173 1384353-1 1992 During the progression of Mg deficiency in a rodent model, we have observed dramatic increases in serum levels of inflammatory cytokines [interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] after 3 wk on a Mg-deficient diet. Magnesium 26-28 interleukin 6 Rattus norvegicus 175-179 1384353-1 1992 During the progression of Mg deficiency in a rodent model, we have observed dramatic increases in serum levels of inflammatory cytokines [interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] after 3 wk on a Mg-deficient diet. Magnesium 26-28 tumor necrosis factor Rattus norvegicus 186-213 1384353-1 1992 During the progression of Mg deficiency in a rodent model, we have observed dramatic increases in serum levels of inflammatory cytokines [interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] after 3 wk on a Mg-deficient diet. Magnesium 26-28 tumor necrosis factor Rattus norvegicus 215-224 1493590-1 1992 Magnesium concentrations in erythrocyte ghosts and arterial tissue of male, spontaneously hypertensive rats (SHR) were significantly less than in these tissues of male normotensive controls (Wistar-Kyoto; WKY) of the same age, which were also fed rat chow and tap water. Magnesium 0-9 nuclear RNA export factor 1 Rattus norvegicus 260-263 1330421-8 1992 Magnesium ions markedly increased the CP-74,667 minimum bactericidal concentrations (MBCs). Magnesium 0-9 hypothetical protein Pseudomonas aeruginosa 38-43 1331782-9 1992 In vitro studies have demonstrated that magnesium can modulate parathyroid hormone (PTH) secretion in a similar way to calcium. Magnesium 40-49 parathyroid hormone Homo sapiens 63-82 1606745-0 1992 Comparison of parathyroid hormone and calcitonin on rat renal calcium and magnesium transport. Magnesium 74-83 parathyroid hormone Rattus norvegicus 14-33 1606745-0 1992 Comparison of parathyroid hormone and calcitonin on rat renal calcium and magnesium transport. Magnesium 74-83 calcitonin-related polypeptide alpha Rattus norvegicus 38-48 1606745-2 1992 Because in vitro adenylate cyclase activity studies suggest that parathyroid hormone (PTH) and calcitonin (CT) increase renal tubular calcium and magnesium reabsorption by stimulating the same transport mechanism, the separate and combined effects of these hormones on calcium and magnesium transport was assessed in the rat. Magnesium 146-155 parathyroid hormone Rattus norvegicus 65-84 1606745-2 1992 Because in vitro adenylate cyclase activity studies suggest that parathyroid hormone (PTH) and calcitonin (CT) increase renal tubular calcium and magnesium reabsorption by stimulating the same transport mechanism, the separate and combined effects of these hormones on calcium and magnesium transport was assessed in the rat. Magnesium 146-155 calcitonin-related polypeptide alpha Rattus norvegicus 95-105 1606745-2 1992 Because in vitro adenylate cyclase activity studies suggest that parathyroid hormone (PTH) and calcitonin (CT) increase renal tubular calcium and magnesium reabsorption by stimulating the same transport mechanism, the separate and combined effects of these hormones on calcium and magnesium transport was assessed in the rat. Magnesium 146-155 calcitonin-related polypeptide alpha Rattus norvegicus 107-109 1606745-2 1992 Because in vitro adenylate cyclase activity studies suggest that parathyroid hormone (PTH) and calcitonin (CT) increase renal tubular calcium and magnesium reabsorption by stimulating the same transport mechanism, the separate and combined effects of these hormones on calcium and magnesium transport was assessed in the rat. Magnesium 281-290 calcitonin-related polypeptide alpha Rattus norvegicus 107-109 1606745-10 1992 These results support biochemical data suggesting that PTH and CT act upon the same transport site, presumably within the thick ascending limb of Henle"s loop, to facilitate calcium and magnesium reabsorption. Magnesium 186-195 calcitonin-related polypeptide alpha Rattus norvegicus 63-65 1390008-6 1992 An inverse relationship between magnesium and renin in the plasma of hypertensives has not been confirmed. Magnesium 32-41 renin Homo sapiens 46-51 1350383-5 1992 NR1-NR2A and NR1-NR2C channels differed in gating behavior and magnesium sensitivity. Magnesium 63-72 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 0-3 1350383-5 1992 NR1-NR2A and NR1-NR2C channels differed in gating behavior and magnesium sensitivity. Magnesium 63-72 glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus 4-8 1350383-5 1992 NR1-NR2A and NR1-NR2C channels differed in gating behavior and magnesium sensitivity. Magnesium 63-72 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 13-16 1350383-5 1992 NR1-NR2A and NR1-NR2C channels differed in gating behavior and magnesium sensitivity. Magnesium 63-72 glutamate ionotropic receptor NMDA type subunit 2C Rattus norvegicus 17-21 1533627-2 1992 The addition of either of these volume-occupying agents enables recA protein to promote homologous pairing and exchange of DNA strands at an otherwise nonpermissive magnesium ion concentration. Magnesium 165-174 RAD51 recombinase Homo sapiens 64-68 1533627-8 1992 Our examination of DNA strand exchange in the presence of volume-occupying agents helps to reconcile the requirement for elevated magnesium ion concentrations in recA protein-promoted recombination reactions in vitro, with a presumably low magnesium ion concentration in vivo. Magnesium 130-139 RAD51 recombinase Homo sapiens 162-166 1533628-8 1992 Therefore, our results indicate dual roles for SSB protein at elevated magnesium ion concentration; it functions during presynapsis, removing secondary structure from ssDNA, as indicated previously, and it also functions postsynaptically, binding to the ssDNA displaced from joint molecules. Magnesium 71-80 small RNA binding exonuclease protection factor La Homo sapiens 47-50 1611299-5 1992 TGF beta also increased alkaline phosphatase activity in two of the cell lines, MG-63 and ROS 17/2.8 but to a greater degree than 1,25(OH)2D3. Magnesium 80-82 transforming growth factor beta 1 Homo sapiens 0-8 1614037-3 1992 The increment in cytosolic Cd2+ was greater in magnesium-depleted cells relative to normal cells. Magnesium 47-56 CD2 molecule Canis lupus familiaris 27-30 1614037-5 1992 These studies indicate that free Cd2+ may exist in the cell cytosol and Cd2+ uptake is greater following magnesium-depletion. Magnesium 105-114 CD2 molecule Canis lupus familiaris 72-75 1406581-3 1992 [alpha-32P]ATP was cross-linked to the SopA protein by UV irradiation; this cross-linking was observed only in the presence of magnesium ion, and was competitively inhibited in the presence of non-radioactive ATP, ADP and dATP, but not other NTPs or dNTPs. Magnesium 127-136 plasmid-partitioning protein SopA Escherichia coli 39-43 1406581-5 1992 The SopA protein showed a modest magnesium ion-dependent ATPase activity and this activity was stimulated in the presence of DNA. Magnesium 33-42 plasmid-partitioning protein SopA Escherichia coli 4-8 1422954-11 1992 Experimental data of the Mg adsorption onto hydroxyapatite were interpreted on the basis of a Langmuir-type model for binary systems assuming competition of Mg2+ and Ca2+ for the same adsorption sites on the crystal surfaces of the apatites. Magnesium 25-27 mucin 7, secreted Homo sapiens 157-160 1511567-0 1992 Conventional and sprinkler needle injection of magnesium insulin. Magnesium 47-56 insulin Homo sapiens 57-64 1511567-3 1992 Magnesium insulin (50 U ml-1) given by sprinkler needle was compared with unmodified human insulin (100 U ml-1) given by conventional needle and unmodified human insulin (50 U ml-1) given by sprinkler needle in normal volunteers using a euglycaemic clamp. Magnesium 0-9 insulin Homo sapiens 10-17 1511567-4 1992 Magnesium insulin had a significantly faster onset of action resulting in a higher exogenous insulin level by 15 min, peak level was reached after 60 min compared with 75 min for the unmodified insulins, and duration of action was significantly shorter than both unmodified insulins. Magnesium 0-9 insulin Homo sapiens 10-17 1511567-4 1992 Magnesium insulin had a significantly faster onset of action resulting in a higher exogenous insulin level by 15 min, peak level was reached after 60 min compared with 75 min for the unmodified insulins, and duration of action was significantly shorter than both unmodified insulins. Magnesium 0-9 insulin Homo sapiens 93-100 1511567-6 1992 Injection of magnesium insulin prior to a test breakfast in people with Type 2 diabetes resulted in significantly lower total and 0 to 120 min areas under the glucose curve, an earlier rise in exogenous insulin levels and a higher area under the insulin curve from 0 to 120 min compared with unmodified 100 U ml-1 human insulin. Magnesium 13-22 insulin Homo sapiens 23-30 1511567-6 1992 Injection of magnesium insulin prior to a test breakfast in people with Type 2 diabetes resulted in significantly lower total and 0 to 120 min areas under the glucose curve, an earlier rise in exogenous insulin levels and a higher area under the insulin curve from 0 to 120 min compared with unmodified 100 U ml-1 human insulin. Magnesium 13-22 insulin Homo sapiens 203-210 1511567-6 1992 Injection of magnesium insulin prior to a test breakfast in people with Type 2 diabetes resulted in significantly lower total and 0 to 120 min areas under the glucose curve, an earlier rise in exogenous insulin levels and a higher area under the insulin curve from 0 to 120 min compared with unmodified 100 U ml-1 human insulin. Magnesium 13-22 insulin Homo sapiens 203-210 1511567-6 1992 Injection of magnesium insulin prior to a test breakfast in people with Type 2 diabetes resulted in significantly lower total and 0 to 120 min areas under the glucose curve, an earlier rise in exogenous insulin levels and a higher area under the insulin curve from 0 to 120 min compared with unmodified 100 U ml-1 human insulin. Magnesium 13-22 insulin Homo sapiens 203-210 1506604-1 1992 This study examined the effects of pregnancy and glucose loading on plasma and erythrocyte (RBC) magnesium (Mg) concentrations. Magnesium 97-106 RNA, 7SL, cytoplasmic 263, pseudogene Homo sapiens 92-95 1506604-9 1992 This redistribution of Mg during late pregnancy could suggest a possible role for RBC as a Mg pool. Magnesium 23-25 RNA, 7SL, cytoplasmic 263, pseudogene Homo sapiens 82-85 1333058-5 1992 Adenosine or its stable analogues (CADO, NECA, CPA) inhibited, in a concentration-dependent manner, both the release of ACh and the force of the indirectly elicited contraction of hemidiaphragm preparation, provided in the latter case that the margin of safety was reduced by (+)-tubocurarine or magnesium. Magnesium 296-305 carboxypeptidase A1, pancreatic Mus musculus 47-50 1625849-15 1992 EDRF physiologically released by venous endothelium seems to be an important factor protecting the veins against non-desirable increases of smooth muscle tone (e.g. at low Mg-ion level of extracellular fluid, or in case of axial overstretch of the vein, etc. Magnesium 172-174 alpha hemoglobin stabilizing protein Homo sapiens 0-4 1636687-0 1992 Osteocalcin and its message: relationship to bone histology in magnesium-deprived rats. Magnesium 63-72 bone gamma-carboxyglutamate protein Rattus norvegicus 0-11 1636687-2 1992 Osteocalcin mRNA was determined in calvaria-derived cells and was correlated to circulating concentrations of the protein after 8 days of Mg deprivation. Magnesium 138-140 bone gamma-carboxyglutamate protein Rattus norvegicus 0-11 1636687-3 1992 Circulating osteocalcin was decreased in Mg-deprived rats when compared with pair-fed normal rats after 8 days of Mg deprivation, with no significant changes in calcium or 1,25-dihydroxyvitamin D [1,25(OH)2D]. Magnesium 41-43 bone gamma-carboxyglutamate protein Rattus norvegicus 12-23 1636687-3 1992 Circulating osteocalcin was decreased in Mg-deprived rats when compared with pair-fed normal rats after 8 days of Mg deprivation, with no significant changes in calcium or 1,25-dihydroxyvitamin D [1,25(OH)2D]. Magnesium 114-116 bone gamma-carboxyglutamate protein Rattus norvegicus 12-23 1636687-4 1992 Serial sampling demonstrated a difference in osteocalcin levels by 2 days of Mg deprivation, before any changes in circulating calcium or parathyroid hormone were present. Magnesium 77-79 bone gamma-carboxyglutamate protein Rattus norvegicus 45-56 1636687-5 1992 Although circulating osteocalcin is decreased in Mg-deprived animals, levels can be stimulated with 1,25(OH)2D3. Magnesium 49-51 bone gamma-carboxyglutamate protein Rattus norvegicus 21-32 1636687-6 1992 Osteocalcin mRNA is reduced after Mg deprivation, suggesting that low circulating levels are due, at least in part, to reduced osteocalcin synthesis. Magnesium 34-36 bone gamma-carboxyglutamate protein Rattus norvegicus 0-11 1636687-6 1992 Osteocalcin mRNA is reduced after Mg deprivation, suggesting that low circulating levels are due, at least in part, to reduced osteocalcin synthesis. Magnesium 34-36 bone gamma-carboxyglutamate protein Rattus norvegicus 127-138 1421312-1 1992 The mechanism of shortening MEPC decay phase after initial prolongation due to acetylcholinesterase inhibition by armine and neostigmine was studied by use of two-electrode voltage-clamp at the mice diaphragm Factors which switch off non-quantal secretion of acetylcholine from the nerve (acute denervation in vitro, ouabain, high concentration of magnesium ions) only slightly reduced the prolongation of MEPC caused by AChE inhibition. Magnesium 348-357 acetylcholinesterase Mus musculus 79-99 1286691-0 1992 [An analysis of the mechanism of the effect of intragastric calcium and magnesium on the release of gastrin and insulin in dogs]. Magnesium 72-81 gastrin Canis lupus familiaris 100-107 1286691-0 1992 [An analysis of the mechanism of the effect of intragastric calcium and magnesium on the release of gastrin and insulin in dogs]. Magnesium 72-81 insulin Canis lupus familiaris 112-119 1286691-5 1992 Atropin (0.03 mg/kg, subcutaneous injection, 10 min before infusion) absolutely takes away the gastrin-stimulating effect of magnesium, but it has almost no influence on the gastrin-inhibitory effect of calcium. Magnesium 125-134 gastrin Canis lupus familiaris 95-102 1335899-0 1992 [The characteristics of the effect of parathyroid hormone on the mechanical activity of the myocardium in rats with a deficiency of Ca and Mg in the drinking water]. Magnesium 139-141 parathyroid hormone Rattus norvegicus 38-57 1512554-9 1992 Results of the fits show that in low internal [Mg2+] the slowing of the decay of the calcium transient can be well predicted by both a decreased rate of SR calcium uptake and an expected decreased resting magnesium occupancy of parvalbumin leading to a reduced contribution of parvalbumin to the overall rate of calcium removal. Magnesium 205-214 parvalbumin Homo sapiens 228-239 1512554-10 1992 These results are thus consistent with the known properties of parvalbumin as a Ca-Mg buffer and furthermore suggest that in an intact portion of a muscle fiber, the activity of the SR calcium pump can be affected by the level of free Mg2+. Magnesium 83-85 parvalbumin Homo sapiens 63-74 1627150-3 1992 One requires magnesium ion and is stimulated by Escherichia coli single-stranded DNA binding protein, whereas the other does not require the ion and shows a higher affinity for a left-handed Z-DNA. Magnesium 13-22 single-stranded DNA-binding protein Escherichia coli 65-100 1392187-4 1992 Supplementation of Mg resulted in a sharp increase in serum PTH level with a rapid disappearance of the dissociation between the two immunoassays of PTH. Magnesium 19-21 parathyroid hormone Homo sapiens 60-63 1392187-4 1992 Supplementation of Mg resulted in a sharp increase in serum PTH level with a rapid disappearance of the dissociation between the two immunoassays of PTH. Magnesium 19-21 parathyroid hormone Homo sapiens 149-152 1479714-4 1992 After the magnesium infusion, significant increases of UV, UCaV, UNaV, FECa and FENa, and a significant decrease of PTH were observed in both NT and EHT while MAP and HR did not change in either group. Magnesium 10-19 parathyroid hormone Homo sapiens 116-119 1507935-12 1992 Recently, ACE inhibitors have been documented to have important magnesium-conserving actions, possibly via their effect on glomerular filtration. Magnesium 64-73 angiotensin I converting enzyme Homo sapiens 10-13 1347044-5 1992 The drug-induced ATPase requires magnesium ions, does not utilize ADP or AMP as substrates, exhibits a half-maximal activation at about 0.5 mM MgATP, and its maximal activity (about 3-5 mumol/mg MDR protein/min) approaches that of the well characterized ion transport ATPases. Magnesium 33-42 dynein axonemal heavy chain 8 Homo sapiens 17-23 1535196-0 1992 Modulation of the affinity of the vasopressin receptor by magnesium ions. Magnesium 58-67 arginine vasopressin Rattus norvegicus 34-45 1591141-3 1992 In spite of a rapid rise of parathyroid hormone (PTH) after intravenous administration of magnesium, a reactive increase in 1,25-dihydroxyvitamin D in serum was absent or delayed. Magnesium 90-99 parathyroid hormone Homo sapiens 28-47 1564419-5 1992 Both PTHrP(1-34) and (1-86) fragments stimulated calcium, inorganic phosphorus and magnesium uptake by the mammary gland and secretion into milk, without any significant effect on milk production. Magnesium 83-92 parathyroid hormone-related protein Capra hircus 5-10 1591141-5 1992 The rise of serum prolactin in response to the increase in PTH was blunted or absent, and is a further example of a transient PTH resistance during the phase of magnesium replenishment. Magnesium 161-170 prolactin Homo sapiens 18-27 1591145-7 1992 It is not known to what extent suboptimal intakes may affect the aging process; however, magnesium-deficient conditions have been associated with neuromuscular and cardiovascular disorders, endocrine disturbances, insulin resistance and Alzheimer"s disease. Magnesium 89-98 insulin Homo sapiens 214-221 1431552-7 1992 The removal of calcium and magnesium blocked the shedding of FcRIII caused by soluble stimuli, whereas it retarded but did not abolish the fall in FcRIII expression when cells were incubated with opsonized particles. Magnesium 27-36 Fc gamma receptor IIIa Homo sapiens 61-67 1616704-0 1992 Magnesium chelation inactivates beta-galactosidase in -20 degrees C storage. Magnesium 0-9 galactosidase beta 1 Homo sapiens 32-50 1731907-5 1992 106, 673-678] and distinct from that of conventional PKC (alpha, beta I/II, and gamma) in its dependence on magnesium concentration and cofactors such as phospholipids, calcium, and phorbol ester; and (iii) it has an apparent molecular weight of 95.7K +/- 0.4K on SDS-PAGE, significantly greater than the other conventional and novel PKCs thus far identified. Magnesium 108-117 protein kinase C alpha type Oryctolagus cuniculus 53-85 1620574-1 1992 Complete absence of magnesium has a two-fold effect on the arterial tone: direct smooth muscle contraction and relaxation via endothelium-derived relaxing factor (EDRF) release. Magnesium 20-29 alpha hemoglobin stabilizing protein Homo sapiens 126-161 1620574-1 1992 Complete absence of magnesium has a two-fold effect on the arterial tone: direct smooth muscle contraction and relaxation via endothelium-derived relaxing factor (EDRF) release. Magnesium 20-29 alpha hemoglobin stabilizing protein Homo sapiens 163-167 1620574-8 1992 The results of the present study demonstrate that both the reduction of magnesium concentration or its complete absence cause an EDRF-mediated relaxation and a directly mediated smooth muscle contraction in the femoral vein of the cat. Magnesium 72-81 alpha hemoglobin stabilizing protein Homo sapiens 129-133 1451633-0 1992 [High molecular weight nuclear matrix phosphoprotein as an analog of the MAP1 protein from brain microtubules associated with DNA in a Mg- dependent manner]. Magnesium 135-137 modulator of apoptosis 1 Homo sapiens 73-77 1309767-2 1992 Unexpectedly, the presence of certain metal ions (magnesium, zinc, manganese, and calcium) stabilized the (GAA)4TTCGC(GAA)4 insert in the rare H-y5 when cloned into either of two different sequence backgrounds. Magnesium 50-59 alpha glucosidase Homo sapiens 107-110 1340086-6 1992 We conclude that small alterations in extracellular magnesium concentration, possibly within the physiological range, are able to modify the basal formation and release of EDRF, and thus alter arterial smooth muscle tone in this vascular bed. Magnesium 52-61 alpha hemoglobin stabilizing protein Homo sapiens 172-176 1300331-7 1992 However, infusion study clearly demonstrated that PTH secretion was significantly increased in Mg-deficient uremic rats compared with Mg-replete counterparts. Magnesium 95-97 parathyroid hormone Rattus norvegicus 50-53 1541384-1 1992 Low levels of magnesium have frequently been reported in diabetes mellitus especially in poorly controlled Type 1 (insulin-dependent) diabetic patients. Magnesium 14-23 insulin Homo sapiens 115-122 1555523-5 1992 The study described below extends these observations to include the demonstration of perturbed AChR-dependent contractile muscle function in a rat model of MG. Magnesium 156-158 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 95-99 1345522-4 1992 After stimulation with calmodulin the activity of Ca(++)-Mg(++)-ATP-ase in all the fractions was lower in diabetic patients than in the controls. Magnesium 57-63 calmodulin 1 Homo sapiens 23-33 1345522-4 1992 After stimulation with calmodulin the activity of Ca(++)-Mg(++)-ATP-ase in all the fractions was lower in diabetic patients than in the controls. Magnesium 57-63 arylsulfatase L Homo sapiens 68-71 1300331-7 1992 However, infusion study clearly demonstrated that PTH secretion was significantly increased in Mg-deficient uremic rats compared with Mg-replete counterparts. Magnesium 134-136 parathyroid hormone Rattus norvegicus 50-53 1300331-9 1992 Taken these data together, it was strongly suggested that Mg depletion might enhance PTH secretion in rat. Magnesium 58-60 parathyroid hormone Rattus norvegicus 85-88 1507598-0 1992 Modification by magnesium of the excitatory effect of oxytocin on electrical and mechanical activities of pregnant human myometrium. Magnesium 16-25 oxytocin/neurophysin I prepropeptide Homo sapiens 54-62 1584312-4 1992 It was suggested that after AChE inhibition the magnesium ions in physiological range of concentrations can modulate the desensitization development on postsynaptic membranes by NS level regulation. Magnesium 48-57 acetylcholinesterase Mus musculus 28-32 1765102-12 1991 [Pi]) was derived from the magnesium-dependent glyceraldehyde-3-phosphate dehydrogenase/phosphoglycerate kinase system assigning free magnesium different values in the physiological range (0.1-2.0 mM). Magnesium 27-36 glyceraldehyde-3-phosphate dehydrogenase Cavia porcellus 47-87 1765102-12 1991 [Pi]) was derived from the magnesium-dependent glyceraldehyde-3-phosphate dehydrogenase/phosphoglycerate kinase system assigning free magnesium different values in the physiological range (0.1-2.0 mM). Magnesium 134-143 glyceraldehyde-3-phosphate dehydrogenase Cavia porcellus 47-87 1765168-2 1991 In the presence of actin, exchange of magnesium bound to LC2 by calcium in dephosphorylated myosin accelerates the digestion of myosin and heavy meromyosin heavy chain and increases the accumulation of a 50 kDa fragment. Magnesium 38-47 actin Oryctolagus cuniculus 19-24 1835934-1 1991 The amino-terminal region of actin participates in the binding of myosin subfragment 1 (S1) during cross-bridge cycling, thereby assisting in the activation of the magnesium-dependent myosin ATPase. Magnesium 164-173 myosin heavy chain 14 Homo sapiens 66-72 1835934-1 1991 The amino-terminal region of actin participates in the binding of myosin subfragment 1 (S1) during cross-bridge cycling, thereby assisting in the activation of the magnesium-dependent myosin ATPase. Magnesium 164-173 myosin heavy chain 14 Homo sapiens 184-190 1687645-6 1991 The formation of syncytia between MT-2 and H9/IIIB cells was magnesium-, energy-, temperature-, and actin-cytoskeleton-dependent, and could be inhibited (65%) by an anti-LFA-1 monoclonal antibody. Magnesium 61-70 integrin subunit alpha L Homo sapiens 170-175 1799661-3 1991 20 mM magnesium shortened the lag phase prior to turbidity development and increased the fibre mass/length ratio (0.28 to 1.23 x 10(13) Da/cm) in a purified fibrin-thrombin system. Magnesium 6-15 coagulation factor II, thrombin Homo sapiens 164-172 1799661-4 1991 In plasma clotted with thrombin, 20 mM magnesium increased fibre mass/length ratios from 0.60 to 1.65 x 10(13) Da/cm. Magnesium 39-48 coagulation factor II, thrombin Homo sapiens 23-31 1683874-4 1991 Binding occurred equally well at 4 degrees C or 37 degrees C. Prior incubation of exogenous TGase with guanosine 5"-triphosphate (GTP), guanosine 5"-diphosphate (GDP), or adenosine triphosphate (ATP) had little effect on the amount bound to matrix, but prior treatment with calcium, magnesium, strontium, or manganese ions enhanced binding 2- to 3-fold. Magnesium 283-292 transglutaminase 1 Homo sapiens 92-97 1745976-6 1991 Subsequent increases in [Ca]i in response to increases in [Ca]e were significantly less in lithium-treated cells, with no difference at maximal [Ca]e. Increases in [Ca]i in response to a submaximal concentration of extracellular magnesium were also blunted in cells pretreated with lithium. Magnesium 229-238 carbonic anhydrase 1 Bos taurus 165-169 1300331-0 1992 Magnesium deficiency enhances secretion of parathyroid hormone in normal and 5/6-nephrectomized uremic rats. Magnesium 0-9 parathyroid hormone Rattus norvegicus 43-62 1786553-0 1991 Both arachidonic acid and 1-oleoyl-2-acetyl glycerol in low magnesium solution induce long-term potentiation in hippocampal CA1 neurons in vitro. Magnesium 60-69 carbonic anhydrase 1 Cavia porcellus 124-127 1939521-0 1991 Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. Magnesium 29-38 parathyroid hormone Homo sapiens 52-71 1939521-1 1991 Magnesium (Mg) deficiency in man may result in hypocalcemia, impaired PTH secretion, and low serum concentrations of 1,25-dihydroxyvitamin D [1,25-(OH)2D]. Magnesium 0-9 parathyroid hormone Homo sapiens 70-73 1939521-5 1991 PTH secretion was impaired, as demonstrated by a fall or no change in serum PTH in 20 of 26 subjects despite a fall in the serum Ca and Mg. Magnesium 136-138 parathyroid hormone Homo sapiens 0-3 1939521-6 1991 In addition, an iv injection of Mg in eight subjects after the diet resulted in a significant rise in PTH from 15 +/- 2 to 19 +/- 2 ng/L (P less than 0.01), whereas a similar injection given to six of the subjects before the diet resulted in a significant fall from 28 +/- 5 to 13 +/- 3 ng/L (P less than 0.001). Magnesium 32-34 parathyroid hormone Homo sapiens 102-105 1939521-9 1991 Also, the rise in serum 1,25-(OH)2D after a 6-h human PTH-(1-34) infusion was significantly less after Mg deprivation. Magnesium 103-105 parathyroid hormone Homo sapiens 54-57 1726594-0 1991 Voltage-dependent block by magnesium of neuronal nicotinic acetylcholine receptor channels in rat phaeochromocytoma cells. Magnesium 27-36 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 49-81 1775222-1 1991 The role of magnesium ions in the inhibitory effect of ethanol on NMDA receptor-mediated population synaptic potentials (pEPSPs) in area CA1 of the hippocampus of the adult rat, was studied. Magnesium 12-21 carbonic anhydrase 1 Rattus norvegicus 137-140 1924369-1 1991 Homologous pairing and strand exchange of DNA are catalyzed by the human homologous pairing protein HPP-1 in a magnesium-dependent, ATP-independent reaction that requires homologous DNA substrates and stoichiometric quantities of HPP-1. Magnesium 111-120 familial progressive hyperpigmentation 1 Homo sapiens 100-105 1924369-1 1991 Homologous pairing and strand exchange of DNA are catalyzed by the human homologous pairing protein HPP-1 in a magnesium-dependent, ATP-independent reaction that requires homologous DNA substrates and stoichiometric quantities of HPP-1. Magnesium 111-120 familial progressive hyperpigmentation 1 Homo sapiens 230-235 1680001-7 1991 From our initial kinetic data, we propose that GroEL exists in two interconvertible forms, one of which is stabilized by the binding of Mg/ATP but associates weakly with the unfolded protein. Magnesium 136-138 GroEL Escherichia coli 47-52 1835306-0 1991 Effect of dietary magnesium on atrial natriuretic peptide release. Magnesium 18-27 natriuretic peptide A Rattus norvegicus 31-57 1835306-2 1991 The present study was conducted to determine the effect of magnesium on ANP secretion. Magnesium 59-68 natriuretic peptide A Rattus norvegicus 72-75 1835306-7 1991 A significant positive correlation was found between plasma magnesium and plasma ANP levels (y = 88 + 23 chi; r = 0.46; P less than 0.01). Magnesium 60-69 natriuretic peptide A Rattus norvegicus 81-84 1772874-0 1991 Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies. Magnesium 88-97 insulin-like growth factor 1 Rattus norvegicus 8-36 1772874-0 1991 Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies. Magnesium 88-97 gonadotropin releasing hormone receptor Rattus norvegicus 41-55 1680165-6 1991 Removal of magnesium ions from the superfusion medium caused a significant potentiation of SAA-evoked responses without having any effect on basal levels of [3H]GABA efflux, a result consistent with an involvement of NMDA-receptor activation. Magnesium 11-20 serum amyloid A cluster Mus musculus 91-94 1907315-5 1991 Magnesium deficiency induced a decrease in the percent composition of apolipoprotein (apo) E and a relative increase in the apo C for VLDL. Magnesium 0-9 apolipoprotein E Rattus norvegicus 70-92 1959050-1 1991 Long chain fatty acids (FA) and 2-monoacylglycerols (MG) are produced by lipoprotein lipase (LPL) from plasma triacylglycerols (TG) in capillaries of adipose tissue and transported to adipocytes for TG synthesis. Magnesium 53-55 lipoprotein lipase Homo sapiens 73-91 1959050-1 1991 Long chain fatty acids (FA) and 2-monoacylglycerols (MG) are produced by lipoprotein lipase (LPL) from plasma triacylglycerols (TG) in capillaries of adipose tissue and transported to adipocytes for TG synthesis. Magnesium 53-55 lipoprotein lipase Homo sapiens 93-96 1959050-5 1991 We postulate that FA and MG enter the IFC in capillaries and flow in the IFC across endothelium and extracellular space to sites in adipocytes where MG are hydrolyzed by MG-lipase (MGL) to FA and glycerol, and FA are esterified in endoplasmic reticulum or transferred to inner mitochondrial membrane for oxidation. Magnesium 25-27 monoglyceride lipase Homo sapiens 170-179 1959050-5 1991 We postulate that FA and MG enter the IFC in capillaries and flow in the IFC across endothelium and extracellular space to sites in adipocytes where MG are hydrolyzed by MG-lipase (MGL) to FA and glycerol, and FA are esterified in endoplasmic reticulum or transferred to inner mitochondrial membrane for oxidation. Magnesium 25-27 monoglyceride lipase Homo sapiens 181-184 1907315-6 1991 In HDL from Mg-deficient rats, the proportion of apo AI was higher than normal, apo AIV was lower than normal and apo E was virtually absent. Magnesium 12-14 apolipoprotein E Rattus norvegicus 114-119 1861632-0 1991 The response of parathyroid hormone to specific changes in either ionized calcium, ionized magnesium, or protein-bound calcium in humans. Magnesium 91-100 parathyroid hormone Homo sapiens 16-35 1676598-7 1991 The order of inhibition, with magnesium as metal cofactor, was ATP greater than GMP-PNP greater than AMP-PNP approximately GTP-gamma-S; with manganese, AMP-PNP was more inhibitory than GTP-gamma-S. Magnesium 30-39 5'-nucleotidase, cytosolic II Homo sapiens 80-83 1676598-8 1991 The inhibition constants, with magnesium as cofactor, were 0.65-2.0 mM for GTP-gamma-S, 0.4-0.8 mM for GMP-PNP, 1.5-2.3 mM for AMP-PNP, and 0.07-0.2 mM for ATP. Magnesium 31-40 5'-nucleotidase, cytosolic II Homo sapiens 103-106 1916220-2 1991 Results of studies on the modulation of skeletal muscle contraction by phosphorylation of myosin regulatory light chains and by exchange of magnesium for calcium in myosin heads were reviewed. Magnesium 140-149 myosin heavy chain 14 Homo sapiens 165-171 1711540-6 1991 This mechanism was dependent on the CD11/CD18 adhesion complex of eosinophils (i.e., inhibited by anti-CD18 MAb) and it was active in the presence of Ca++ and Mg++ or Mg++ only, but not Ca++ only. Magnesium 159-163 integrin subunit beta 2 Homo sapiens 41-45 1711540-6 1991 This mechanism was dependent on the CD11/CD18 adhesion complex of eosinophils (i.e., inhibited by anti-CD18 MAb) and it was active in the presence of Ca++ and Mg++ or Mg++ only, but not Ca++ only. Magnesium 159-163 integrin subunit beta 2 Homo sapiens 103-107 1711540-6 1991 This mechanism was dependent on the CD11/CD18 adhesion complex of eosinophils (i.e., inhibited by anti-CD18 MAb) and it was active in the presence of Ca++ and Mg++ or Mg++ only, but not Ca++ only. Magnesium 167-171 integrin subunit beta 2 Homo sapiens 41-45 1711540-6 1991 This mechanism was dependent on the CD11/CD18 adhesion complex of eosinophils (i.e., inhibited by anti-CD18 MAb) and it was active in the presence of Ca++ and Mg++ or Mg++ only, but not Ca++ only. Magnesium 167-171 integrin subunit beta 2 Homo sapiens 103-107 1712876-3 1991 In this report, it is shown that, in the presence of Mn2+, MG-63 cells attach more efficiently to vitronectin and acquire the de novo capacity to adhere to fg- and vWf-coated surfaces. Magnesium 59-61 vitronectin Homo sapiens 98-109 1712876-3 1991 In this report, it is shown that, in the presence of Mn2+, MG-63 cells attach more efficiently to vitronectin and acquire the de novo capacity to adhere to fg- and vWf-coated surfaces. Magnesium 59-61 von Willebrand factor Homo sapiens 164-167 1712876-6 1991 An antiserum to the beta 3 chain and a synthetic peptide containing the sequence Gly-Arg-Gly-Asp-Ser-Pro block MG-63 attachment to fg and vWf in the presence of Mn2+. Magnesium 111-113 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 20-26 1712876-6 1991 An antiserum to the beta 3 chain and a synthetic peptide containing the sequence Gly-Arg-Gly-Asp-Ser-Pro block MG-63 attachment to fg and vWf in the presence of Mn2+. Magnesium 111-113 von Willebrand factor Homo sapiens 138-141 1712876-8 1991 These data suggest that the acquired capacity of MG-63 to attach to fg and vWf in the presence of Mn2+ is mediated by alpha v beta 3 and that differences in alpha v beta 3 receptor specificity may be modulated by exogenous factors. Magnesium 49-51 von Willebrand factor Homo sapiens 75-78 1712876-8 1991 These data suggest that the acquired capacity of MG-63 to attach to fg and vWf in the presence of Mn2+ is mediated by alpha v beta 3 and that differences in alpha v beta 3 receptor specificity may be modulated by exogenous factors. Magnesium 49-51 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 118-132 1712876-8 1991 These data suggest that the acquired capacity of MG-63 to attach to fg and vWf in the presence of Mn2+ is mediated by alpha v beta 3 and that differences in alpha v beta 3 receptor specificity may be modulated by exogenous factors. Magnesium 49-51 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 126-132 1645258-6 1991 Increasing extracellular Ca++ and magnesium (Mg++) from 0 and 0.5 mM, respectively, to 5.0 mM inhibited PTH-dependent (3 x 10(-9) M) cAMP production by 54 +/- 4% and 47 +/- 6%, respectively. Magnesium 34-43 parathyroid hormone Homo sapiens 104-107 1645258-6 1991 Increasing extracellular Ca++ and magnesium (Mg++) from 0 and 0.5 mM, respectively, to 5.0 mM inhibited PTH-dependent (3 x 10(-9) M) cAMP production by 54 +/- 4% and 47 +/- 6%, respectively. Magnesium 45-49 parathyroid hormone Homo sapiens 104-107 1916220-4 1991 It was found that both the exchange of bound magnesium for calcium on myosin heads and the phosphorylation of myosin regulatory light chains control the ability of myosin heads to induce, upon binding to actin, conformational changes of thin filament leading to decrease or increase of its flexibility. Magnesium 45-54 myosin heavy chain 14 Homo sapiens 70-76 1680001-6 1991 The complex between GroEL and denatured LDH is destabilized by the binding of magnesium/ATP (Mg/ATP) or by the nonhydrolyzable analogue adenylyl imidodiphosphate (AMP-PNP). Magnesium 78-87 GroEL Escherichia coli 20-25 1680001-6 1991 The complex between GroEL and denatured LDH is destabilized by the binding of magnesium/ATP (Mg/ATP) or by the nonhydrolyzable analogue adenylyl imidodiphosphate (AMP-PNP). Magnesium 93-95 GroEL Escherichia coli 20-25 1648589-0 1991 Effects of two synthetic parathyroid hormone-related protein fragments on maternofetal transfer of calcium and magnesium and release of cyclic AMP by the in-situ perfused rat placenta. Magnesium 111-120 parathyroid hormone like hormone Homo sapiens 25-60 1850349-8 1991 Mg++ ion dose-dependently reduced the affinity of GnRHa binding, without changing the maximum binding capacity, and also attenuated the increase in GnRHa binding produced by NPY. Magnesium 0-4 neuropeptide Y Rattus norvegicus 174-177 2030253-2 1991 Twenty-seven term infants born after uncomplicated pregnancies, labors, and deliveries were studied to test the hypothesis that in normal newborns the amplitude of parathyroid hormone (PTH) response to decreasing serum ionized calcium (iCa) correlates with serum magnesium (Mg) concentrations. Magnesium 263-272 parathyroid hormone Homo sapiens 164-183 2030253-2 1991 Twenty-seven term infants born after uncomplicated pregnancies, labors, and deliveries were studied to test the hypothesis that in normal newborns the amplitude of parathyroid hormone (PTH) response to decreasing serum ionized calcium (iCa) correlates with serum magnesium (Mg) concentrations. Magnesium 274-276 parathyroid hormone Homo sapiens 164-183 2018502-0 1991 Synergistic effect of magnesium and calcium ions in the activation of phospholipase A2 of liver macrophages. Magnesium 22-31 phospholipase A2 group IB Rattus norvegicus 70-86 1874207-6 1991 Plasma renin activity increased during hypotension but the inhibitory effects of magnesium on angiotensin converting enzyme prevented angiotensin-II-associated hypertension. Magnesium 81-90 angiotensinogen Homo sapiens 134-148 1880809-0 1991 Magnesium inhibits the responses to neuropeptide Y in the rabbit coronary artery. Magnesium 0-9 neuropeptide Y Oryctolagus cuniculus 36-50 1880809-3 1991 Since magnesium is known to be a physiological antagonist of calcium and to have a profound influence on the contraction of coronary vascular smooth muscle, we examined the importance of magnesium in modulating both the direct vasoconstrictor response to NPY and the NPY-induced inhibition of relaxation to noradrenaline, using ring preparations of rabbit circumflex coronary artery. Magnesium 187-196 neuropeptide Y Oryctolagus cuniculus 255-258 1706431-4 1991 Procaine, ruthenium red or Mg++ caused concentration-dependent inhibition of MBED-triggered Ca++ release from HSR. Magnesium 27-31 HSR Homo sapiens 110-113 2046484-0 1991 Effect of magnesium deficiency on post-heparin lipase activity and tissue lipoprotein lipase in the rat. Magnesium 10-19 lipoprotein lipase Rattus norvegicus 74-92 2046484-9 1991 The results indicate that hepatic lipase is significantly decreased in Mg-deficient rats but the low PHLA is due mainly to a decline in LPL. Magnesium 71-73 lipase C, hepatic type Rattus norvegicus 26-40 2046484-11 1991 The results suggest that the decrease of LPL activity in the plasma of Mg-deficient rats may be due to a selective decrease in the heparin-releasable pool of enzyme. Magnesium 71-73 lipoprotein lipase Rattus norvegicus 41-44 2017365-1 1991 (Deoxy)thymidylate (dTMP) kinase is an enzyme which phosphorylates dTMP to dTDP in the presence of ATP and magnesium. Magnesium 107-116 TAR DNA-binding protein-43 homolog Drosophila melanogaster 75-79 2029773-4 1991 Moreover, in malignant hypercalcemia, our results suggested that PTH-like peptides might be less effective than PTH in renal handling of Mg as previously described for Ca. Magnesium 137-139 parathyroid hormone Homo sapiens 65-68 1676831-0 1991 Regulation of CCK release in cerebral cortex by N-methyl-D-aspartate receptors: sensitivity to APV, MK-801, kynurenate, magnesium and zinc ions. Magnesium 120-129 cholecystokinin Rattus norvegicus 14-17 1847589-9 1991 Conversely, divalent ions like calcium and magnesium enhance the binding of ET-1 to both uterine membranes and cells. Magnesium 43-52 endothelin-1 Oryctolagus cuniculus 76-80 1653033-2 1991 Homologous pairing of model DNA substrates is catalyzed by the homologous pairing protein HPP-1 in a magnesium-dependent, ATP-independent reaction that requires stoichiometric amounts of the protein. Magnesium 101-110 familial progressive hyperpigmentation 1 Homo sapiens 90-95 2007001-5 1991 Plasma beta-endorphin concentration was 45.1 +/- 13.4 in the control group, 70.7 +/- 17.4 in the Ca-group (P less than .05 v control group), 58.0 +/- 20.1 in the Mg-group and 83.8 +/- 24.8 in the Ca/Mg-group (P less than .01 v control group). Magnesium 162-164 pro-opiomelanocortin-alpha Mus musculus 7-21 2059339-2 1991 In the presence of Mg++, poly(dC) and poly(dG) form a very stable triple helix at neutral pH, based on G-G-C triplexes, whereas Zn++ prevents its formation, both at neutral and acidic pH. Magnesium 19-23 gamma-glutamylcyclotransferase Homo sapiens 103-108 1828780-5 1991 The assembly of GFAP is critically dependent upon both protein and magnesium ion concentration, and at the critical concentration for GFAP assembly is approximately 40 micrograms/ml. Magnesium 67-76 glial fibrillary acidic protein Homo sapiens 16-20 1723120-10 1991 Angiotensin II may increase the sensitivity to sympathetic nervous system arousal but also promotes renal loss of potassium and magnesium. Magnesium 128-137 angiotensinogen Homo sapiens 0-14 2037862-3 1991 Insulin was positively correlated with serum glucose, body mass index (BMI), skinfold thickness, waist/hip ratio and sucrose intake, and negatively correlated with heavy physical activity score, treadmill exercise duration, and magnesium intake (each p less than 0.01). Magnesium 228-237 insulin Homo sapiens 0-7 1987306-2 1991 In response to treatment, the serum magnesium concentration fell progressively in association with a rise in serum and urinary calcium levels and a decrease in parathyroid hormone level. Magnesium 36-45 parathyroid hormone Homo sapiens 160-179 1987306-4 1991 However, in the present study, increases in serum and urinary calcium levels and suppression of parathyroid hormone, factors known to decrease magnesium reabsorption, presumably overwhelmed any direct effect calcitriol may have had to enhance magnesium reabsorption, so that the net effect was a marked exacerbation of the renal magnesium wasting. Magnesium 143-152 parathyroid hormone Homo sapiens 96-115 1844554-3 1991 The clinical consequences of magnesium deficiency include impairment of insulin secretion, insulin resistance and increased macrovascular risk. Magnesium 29-38 insulin Homo sapiens 72-79 1875781-3 1991 The membrane-bound COMT activities ranged from 33 to 60 pmol/min mg in the different parts of the intestine. Magnesium 65-67 catechol-O-methyltransferase Homo sapiens 19-23 2056930-5 1991 Evidence is presented to support the hypothesis that in subjects with parathyroid hyperactivity and Mg++ deficiency, the stimulus of a rise in serum ionic calcium (Ca++), and the resultant inhibition of parathyroid hormone (PTH) secretion, trigger the transfer of Ca++, Mg++ and other ions from the extracellular space into the exchangeable bone compartment. Magnesium 100-104 parathyroid hormone Homo sapiens 203-222 2056930-5 1991 Evidence is presented to support the hypothesis that in subjects with parathyroid hyperactivity and Mg++ deficiency, the stimulus of a rise in serum ionic calcium (Ca++), and the resultant inhibition of parathyroid hormone (PTH) secretion, trigger the transfer of Ca++, Mg++ and other ions from the extracellular space into the exchangeable bone compartment. Magnesium 270-274 parathyroid hormone Homo sapiens 203-222 1823392-1 1991 The objective of this study was to evaluate the effect of low dose magnesium supplement upon maternal and fetal serum levels of mineral status in pregnancies complicated with hypertension (PIH). Magnesium 67-76 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 189-192 1646408-0 1991 Theophylline and magnesium inhibit the contraction elicited with ciclosporin and angiotensin II in mesangial cell cultures. Magnesium 17-26 angiotensinogen Homo sapiens 81-95 2280429-6 1990 Analysis of the tap water samples showed "soft water" by analysis of calcium and magnesium concentration. Magnesium 81-90 nuclear RNA export factor 1 Rattus norvegicus 16-19 2173703-0 1990 The liver glucose-6-phosphatase of intact microsomes is inhibited and displays sigmoid kinetics in the presence of alpha-ketoglutarate-magnesium and oxaloacetate-magnesium chelates. Magnesium 135-144 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 10-31 2173703-1 1990 We have recently shown that the Ca.EGTA and Mg.EDTA complexes, but not free Ca2+ or Mg2+, inhibit the liver glucose-6-phosphatase (Mithieux, G., Vega, F. V., Beylot, M., and Riou, J. P. (1990) J. Biol. Magnesium 44-46 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 108-129 2242586-0 1990 Determination of magnesium in serum by the technicon SMAC with a calmagite method with blank correction. Magnesium 17-26 diablo IAP-binding mitochondrial protein Homo sapiens 53-57 2212670-8 1990 In parallel studies, 51Cr-labeled platelets bound equally well to collagen- or C1q-coated surfaces, albeit in a magnesium-dependent manner. Magnesium 112-121 complement C1q A chain Homo sapiens 79-82 2125519-5 1990 The action of TRH persisted in a low-calcium, high-magnesium solution which blocks synaptic transmission. Magnesium 51-60 thyrotropin releasing hormone Rattus norvegicus 14-17 1874207-6 1991 Plasma renin activity increased during hypotension but the inhibitory effects of magnesium on angiotensin converting enzyme prevented angiotensin-II-associated hypertension. Magnesium 81-90 angiotensin I converting enzyme Homo sapiens 94-123 1957034-0 1991 Role of the fetal parathyroid glands and parathyroid hormone-related protein in the regulation of placental transport of calcium, magnesium and inorganic phosphate. Magnesium 130-139 parathyroid hormone like hormone Homo sapiens 41-76 1957034-6 1991 Extracts of fetal parathyroid glands and purified PTHrP, as well as recombinant PTHrP (1-84, 1-108 and 1-141), stimulate Ca and Mg but not PO4 transport across the placenta of TxPTx-ized fetuses perfused with autologous blood in the absence of the fetus. Magnesium 128-130 parathyroid hormone like hormone Homo sapiens 50-55 1957034-6 1991 Extracts of fetal parathyroid glands and purified PTHrP, as well as recombinant PTHrP (1-84, 1-108 and 1-141), stimulate Ca and Mg but not PO4 transport across the placenta of TxPTx-ized fetuses perfused with autologous blood in the absence of the fetus. Magnesium 128-130 parathyroid hormone like hormone Homo sapiens 80-85 2124107-3 1990 In this report, we have characterized the interaction of monomeric actin, coated on plastic plates under conditions of non-polymerization, with alpha-actinin in presence of magnesium. Magnesium 173-182 actinin alpha 1 Homo sapiens 144-157 2173703-8 1990 The disruption of microsomal integrity by detergents abolishes the effect of Mg.alpha-KG and Mg.OAA, suggesting that the magnesium chelates inhibit the translocase component of the glucose-6-phosphatase system. Magnesium 77-79 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 181-202 2173703-8 1990 The disruption of microsomal integrity by detergents abolishes the effect of Mg.alpha-KG and Mg.OAA, suggesting that the magnesium chelates inhibit the translocase component of the glucose-6-phosphatase system. Magnesium 93-95 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 181-202 2173703-8 1990 The disruption of microsomal integrity by detergents abolishes the effect of Mg.alpha-KG and Mg.OAA, suggesting that the magnesium chelates inhibit the translocase component of the glucose-6-phosphatase system. Magnesium 121-130 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 181-202 2265206-0 1990 Response of rat liver glutaminase to magnesium ion. Magnesium 37-46 glutaminase Rattus norvegicus 22-33 2398047-8 1990 p76-kinase did not respond to calcium, had a lower requirement for magnesium, and a higher affinity for histone III-S than PKC. Magnesium 67-76 phospholipase B domain containing 2 Mus musculus 0-3 1977163-4 1990 Instrumental to its identification, mitochondrial cpn10 and bacterial cpn60 form a stable complex in the presence of Mg.ATP. Magnesium 117-119 heat shock protein family E (Hsp10) member 1 Rattus norvegicus 50-55 1977163-4 1990 Instrumental to its identification, mitochondrial cpn10 and bacterial cpn60 form a stable complex in the presence of Mg.ATP. Magnesium 117-119 heat shock protein family D (Hsp60) member 1 Rattus norvegicus 70-75 2253826-2 1990 The relationship between insulin and magnesium has been recently studied. Magnesium 37-46 insulin Homo sapiens 25-32 2253826-3 1990 In particular it has been shown that magnesium plays the role of a second messenger for insulin action; on the other hand, insulin itself has been demonstrated to be an important regulatory factor of intracellular magnesium accumulation. Magnesium 37-46 insulin Homo sapiens 88-95 2253826-3 1990 In particular it has been shown that magnesium plays the role of a second messenger for insulin action; on the other hand, insulin itself has been demonstrated to be an important regulatory factor of intracellular magnesium accumulation. Magnesium 214-223 insulin Homo sapiens 123-130 2253826-4 1990 Conditions associated with insulin resistance, such as hypertension or aging, are also associated with low intracellular magnesium contents. Magnesium 121-130 insulin Homo sapiens 27-34 2253826-5 1990 In diabetes mellitus, it is suggested that low intracellular magnesium levels result from both increased urinary losses and insulin resistance. Magnesium 61-70 insulin Homo sapiens 124-131 2253826-7 1990 A reduced intracellular magnesium content might contribute to the impaired insulin response and action which occurs in Type 2 (non-insulin-dependent) diabetes mellitus. Magnesium 24-33 insulin Homo sapiens 75-82 2253826-8 1990 Chronic magnesium supplementation can contribute to an improvement in both islet Beta-cell response and insulin action in non-insulin-dependent diabetic subjects. Magnesium 8-17 insulin Homo sapiens 104-111 2253826-8 1990 Chronic magnesium supplementation can contribute to an improvement in both islet Beta-cell response and insulin action in non-insulin-dependent diabetic subjects. Magnesium 8-17 insulin Homo sapiens 126-133 2384761-2 1990 The specific binding of NPY decreased as the magnesium concentration increased from 1.05 to 10 mM. Magnesium 45-54 neuropeptide Y Homo sapiens 24-27 1700914-6 1990 It was concluded that a mid-molecule portion of PTHrP can stimulate a putative placental pump which is responsible for the gradients of both calcium ions and magnesium across the ovine placenta. Magnesium 158-167 parathyroid hormone-related protein Ovis aries 48-53 2257962-5 1990 Calcium and especially magnesium at physiological concentrations of 2.5 and 5 mM, respectively, increased NKa compared with values obtained in chromatographed serum, whereas at supraphysiological concentrations of magnesium of 15 mM NKa was reduced. Magnesium 23-32 tachykinin precursor 1 Homo sapiens 106-109 2257962-5 1990 Calcium and especially magnesium at physiological concentrations of 2.5 and 5 mM, respectively, increased NKa compared with values obtained in chromatographed serum, whereas at supraphysiological concentrations of magnesium of 15 mM NKa was reduced. Magnesium 23-32 tachykinin precursor 1 Homo sapiens 233-236 2132752-4 1990 Further research should seek to control the alterations of albumin, which may induce this brain Mg depletion. Magnesium 96-98 albumin Homo sapiens 59-66 1978344-1 1990 We have investigated the effect of magnesium on the single-channel conductance of neuronal nicotinic acetylcholine receptors (nAChRs) in nerve growth-factor treated rat pheochromocytoma (PC12) cells. Magnesium 35-44 nerve growth factor Rattus norvegicus 137-156 2214606-8 1990 Without magnesium 80% of the cells contracted upon addition of angiotensin II. Magnesium 8-17 angiotensinogen Rattus norvegicus 63-77 2381136-2 1990 Parathyroid hormone was immeasurably or inadequately low in all patients before magnesium injection, but rapidly rose to elevated values thereafter. Magnesium 80-89 parathyroid hormone Homo sapiens 0-19 2401639-10 1990 Lambs fed the control and Mg-Mica diets absorbed similar (P greater than .05) quantities of Mg in the preintestinal region and less (P less than .05) than lambs fed the MgO, MgC and MgOH diets. Magnesium 26-28 MHC class I polypeptide-related sequence B Ovis aries 29-33 2371022-0 1990 Modification by magnesium of the excitatory effect of oxytocin in electrical and mechanical activities of pregnant human myometrium. Magnesium 16-25 oxytocin/neurophysin I prepropeptide Homo sapiens 54-62 2371022-1 1990 The modification by magnesium of the excitatory effect of oxytocin (10(-5)-10(-2) U/mL) on electrical and mechanical activities of pregnant human myometrium was examined. Magnesium 20-29 oxytocin/neurophysin I prepropeptide Homo sapiens 58-66 2371022-2 1990 The excitatory effect of oxytocin was enhanced by external magnesium, and the dose-response curve between oxytocin and relative tension in the presence of 118 mM potassium in tiny muscle strips shifted to the left with increases in magnesium from 0 to 2.4 mM. Magnesium 59-68 oxytocin/neurophysin I prepropeptide Homo sapiens 25-33 2371022-2 1990 The excitatory effect of oxytocin was enhanced by external magnesium, and the dose-response curve between oxytocin and relative tension in the presence of 118 mM potassium in tiny muscle strips shifted to the left with increases in magnesium from 0 to 2.4 mM. Magnesium 232-241 oxytocin/neurophysin I prepropeptide Homo sapiens 25-33 2371022-2 1990 The excitatory effect of oxytocin was enhanced by external magnesium, and the dose-response curve between oxytocin and relative tension in the presence of 118 mM potassium in tiny muscle strips shifted to the left with increases in magnesium from 0 to 2.4 mM. Magnesium 232-241 oxytocin/neurophysin I prepropeptide Homo sapiens 106-114 2371022-3 1990 Oxytocin potentiates spontaneous contractions by enhancing the plateau part of action potentials, and the plateau potential induced in 2.4-mM magnesium was larger than that in magnesium-free solution. Magnesium 142-151 oxytocin/neurophysin I prepropeptide Homo sapiens 0-8 2371022-3 1990 Oxytocin potentiates spontaneous contractions by enhancing the plateau part of action potentials, and the plateau potential induced in 2.4-mM magnesium was larger than that in magnesium-free solution. Magnesium 176-185 oxytocin/neurophysin I prepropeptide Homo sapiens 0-8 2371022-4 1990 In potassium contracture experiments, the muscle contraction was potentiated in accordance with the concentration of preloaded magnesium when 10(-3) U/mL oxytocin was added at the tonic phase. Magnesium 127-136 oxytocin/neurophysin I prepropeptide Homo sapiens 154-162 2371022-5 1990 These results suggest that magnesium might primarily potentiate the excitatory effect of oxytocin in electrical and mechanical activities of pregnant human myometrium at superficial sites of the plasma membrane, allowing the possibility of its intracellular action. Magnesium 27-36 oxytocin/neurophysin I prepropeptide Homo sapiens 89-97 2384166-2 1990 In millimolar magnesium, NaF at concentrations above 3 mM is active even in the absence of aluminium or beryllium. Magnesium 14-23 C-X-C motif chemokine ligand 8 Homo sapiens 25-28 2384166-5 1990 We propose that at high NaF concentrations, 3 hydrogen-bonded fluorides in the gamma-phosphate site of T alpha GDP entrap a magnesium counterion and this induces the transconformation to the T alpha GTP form. Magnesium 124-133 C-X-C motif chemokine ligand 8 Homo sapiens 24-27 2164802-5 1990 Moreover, the fact that Mg.ATP primes responses stimulated by fMLP, GTP gamma S and PMA suggests that the modulatory effect is at the level of protein kinase C. Magnesium 24-26 formyl peptide receptor 1 Homo sapiens 62-66 2381136-6 1990 The findings were considered to be due to partial parathyroid hormone resistance during the phase of magnesium replenishment. Magnesium 101-110 parathyroid hormone Homo sapiens 50-69 2265738-0 1990 Impaired insulin-mediated erythrocyte magnesium accumulation is correlated to impaired insulin-mediated glucose diposal in aged non-diabetic obese patients. Magnesium 38-47 insulin Homo sapiens 9-16 2265738-2 1990 In vitro incubation in the presence of 100 mU/l insulin significantly increased magnesium erythrocyte levels in both groups of subjects. Magnesium 80-89 insulin Homo sapiens 48-55 2265738-5 1990 Such reduction of the maximal effect of insulin suggests that the impairment of insulin-induced erythrocyte magnesium accumulation observed in obese patients results essentially from a post-receptor defect. Magnesium 108-117 insulin Homo sapiens 40-47 2265738-5 1990 Such reduction of the maximal effect of insulin suggests that the impairment of insulin-induced erythrocyte magnesium accumulation observed in obese patients results essentially from a post-receptor defect. Magnesium 108-117 insulin Homo sapiens 80-87 2265738-6 1990 In obese patients, net increase in erythrocyte magnesium levels (calculated as the difference between basal and 100 mU/l insulin-induced erythrocyte magnesium levels) was negatively correlated with basal plasma insulin levels (r = 0.79 p less than 0.01), and with body mass index (r = 0.81 p less than 0.01) while it was positively correlated with the glucose disappearance rate after glucose load (r = 0.67 p less than 0.05) and glucose metabolic clearance rate (r = 0.71 p less than 0.01). Magnesium 47-56 insulin Homo sapiens 121-128 2265738-6 1990 In obese patients, net increase in erythrocyte magnesium levels (calculated as the difference between basal and 100 mU/l insulin-induced erythrocyte magnesium levels) was negatively correlated with basal plasma insulin levels (r = 0.79 p less than 0.01), and with body mass index (r = 0.81 p less than 0.01) while it was positively correlated with the glucose disappearance rate after glucose load (r = 0.67 p less than 0.05) and glucose metabolic clearance rate (r = 0.71 p less than 0.01). Magnesium 47-56 insulin Homo sapiens 211-218 2265738-6 1990 In obese patients, net increase in erythrocyte magnesium levels (calculated as the difference between basal and 100 mU/l insulin-induced erythrocyte magnesium levels) was negatively correlated with basal plasma insulin levels (r = 0.79 p less than 0.01), and with body mass index (r = 0.81 p less than 0.01) while it was positively correlated with the glucose disappearance rate after glucose load (r = 0.67 p less than 0.05) and glucose metabolic clearance rate (r = 0.71 p less than 0.01). Magnesium 149-158 insulin Homo sapiens 121-128 2265738-7 1990 These results demonstrate that insulin-induced erythrocyte magnesium accumulation is impaired in patients with obesity and that such defect is correlated to impaired -- mediated glucosal disposal in the patients. Magnesium 59-68 insulin Homo sapiens 31-38 2387288-0 1990 Hippocampal epileptiform activity induced by magnesium-free medium: differences between areas CA1 and CA2-3. Magnesium 45-54 carbonic anhydrase 1 Homo sapiens 94-97 2387288-0 1990 Hippocampal epileptiform activity induced by magnesium-free medium: differences between areas CA1 and CA2-3. Magnesium 45-54 carbonic anhydrase 2 Homo sapiens 102-107 2387288-10 1990 In the hippocampal slice exposed to low magnesium, IIBs originate in CA2-3 and are propagated to CA1, where they can have a suppressant effect on EGSs. Magnesium 40-49 carbonic anhydrase 2 Homo sapiens 69-74 2387288-10 1990 In the hippocampal slice exposed to low magnesium, IIBs originate in CA2-3 and are propagated to CA1, where they can have a suppressant effect on EGSs. Magnesium 40-49 carbonic anhydrase 1 Homo sapiens 97-100 1979036-3 1990 Stimulation of beta 1-adrenergic receptor with isoproterenol and beta 2-adrenergic antagonist ICI 118.551 inhibited the fractional reabsorption of sodium, chloride and magnesium, the fluid reabsorption being changed insignificantly. Magnesium 168-177 adrenoceptor beta 1 Homo sapiens 15-41 1979036-3 1990 Stimulation of beta 1-adrenergic receptor with isoproterenol and beta 2-adrenergic antagonist ICI 118.551 inhibited the fractional reabsorption of sodium, chloride and magnesium, the fluid reabsorption being changed insignificantly. Magnesium 168-177 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 65-71 2223059-0 1990 Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein. Magnesium 56-65 parathyroid hormone like hormone Homo sapiens 101-136 2223059-1 1990 Perfusion in situ of the placenta of intact or previously parathyroidectomized fetal lambs has been used to assess the ability of three mid-molecule fragments of the human parathyroid hormone-related protein (PTHrP) molecule to stimulate the placental transport of calcium and magnesium. Magnesium 277-286 parathyroid hormone like hormone Homo sapiens 172-207 2223059-1 1990 Perfusion in situ of the placenta of intact or previously parathyroidectomized fetal lambs has been used to assess the ability of three mid-molecule fragments of the human parathyroid hormone-related protein (PTHrP) molecule to stimulate the placental transport of calcium and magnesium. Magnesium 277-286 parathyroid hormone like hormone Homo sapiens 209-214 1695751-5 1990 This effect of Mg is related to the activation of sodium-potassium ATP-ase, which is inhibited by digitalis. Magnesium 15-17 dynein axonemal heavy chain 8 Homo sapiens 67-74 1972782-2 1990 Because LTP in this region is blocked by the NMDA (N-methyl-D-aspartate) receptor antagonist AP5 (DL-2-amino-5-phosphonovaleric acid) and the calcium permeability of NMDA receptors is controlled by a voltage-dependent magnesium block, a model has emerged that suggests that the calcium permeability of NMDA receptor-coupled ion channels is the biophysical basis for LTP induction. Magnesium 218-227 adaptor related protein complex 5 subunit beta 1 Homo sapiens 93-96 2383570-6 1990 The number of weak magnesium binding sites was determined to be 50 +/- 8 in the native conformation and a total line-shape analysis of the exchange-broadened 25 Mg2+ NMR resonance gave an association constant Ka of (2.2 +/- 0.2) X 10(2) M-1, a quadrupolar coupling constant (chi B) of 0.84 MHz, an activation free energy (delta G*) of 12.8 +/- 0.2 kcal mol-1, and an off-rate (koff) of (2.5 +/- 0.4) X 10(3) s-1. Magnesium 19-28 thiamine thiazole synthase Saccharomyces cerevisiae S288C 353-358 2111819-3 1990 At 30 degrees C, Sec4p bound [35S] guanosine 5"-O-(thiotriphosphate) (GTP gamma S) with a rate of 0.18 min-1 in a reaction requiring micromolar concentration of free magnesium ions. Magnesium 166-175 Rab family GTPase SEC4 Saccharomyces cerevisiae S288C 17-22 2196065-0 1990 Effects of magnesium on changes in blood pressure and plasma aldosterone induced by angiotensin II. Magnesium 11-20 angiotensinogen Rattus norvegicus 84-98 2196065-1 1990 This study examined the effects of magnesium on changes in blood pressure and plasma aldosterone concentration (PAC) elicited by angiotensin II in rats. Magnesium 35-44 angiotensinogen Rattus norvegicus 129-143 2196065-4 1990 These effects of magnesium were abolished when endogenous angiotensin II was suppressed by the administration of captopril, an angiotensin converting enzyme inhibitor. Magnesium 17-26 angiotensinogen Rattus norvegicus 58-72 2133624-2 1990 This paper describes how the authors, after examining the calcium modulating action of the Mg ion and its antihistamine-like action, tested a salt containing Mg (Mg pidolate, MAG2) in the clinical treatment of seasonal allergic rhinitis. Magnesium 91-93 reticulophagy regulator family member 2 Homo sapiens 175-179 2149086-0 1990 Developmental increase in the sensitivity to magnesium of NMDA receptors on CA1 hippocampal pyramidal cells. Magnesium 45-54 carbonic anhydrase 1 Rattus norvegicus 76-79 2133624-2 1990 This paper describes how the authors, after examining the calcium modulating action of the Mg ion and its antihistamine-like action, tested a salt containing Mg (Mg pidolate, MAG2) in the clinical treatment of seasonal allergic rhinitis. Magnesium 158-160 reticulophagy regulator family member 2 Homo sapiens 175-179 2140359-2 1990 At pH 7.0 and 5 degrees C, in the absence of potassium and magnesium, the Ca-ATPase of the sarcoplasmic reticulum slowly hydrolyzes the Ca.ATP at a rate of 0.05 s-1. Magnesium 59-68 dynein axonemal heavy chain 8 Homo sapiens 77-83 2190608-6 1990 We hypothesize that hypertension and peripheral insulin resistance may be different clinical expressions of a common abnormal intracellular ionic environment, characterized at least in part by suppressed levels of intracellular free magnesium. Magnesium 233-242 insulin Homo sapiens 48-55 2144190-0 1990 [The effect of magnesium ions on the two-stage kinetics of superprecipitation and ATPase activity of natural actomyosin]. Magnesium 15-24 dynein axonemal heavy chain 8 Homo sapiens 82-88 2372661-0 1990 Calcium antagonizes the magnesium-induced high affinity state of the hepatic vasopressin receptor for the agonist interaction. Magnesium 24-33 arginine vasopressin Homo sapiens 77-88 2184947-5 1990 The enhancing effects of insulin on the STA2-induced contractions were affected by extracellular glucose or magnesium ion concentrations. Magnesium 108-117 insulin Homo sapiens 25-32 2184947-6 1990 The enhancing effects of insulin were observed only at the glucose concentrations of 100-300 mg/dl and magnesium concentrations of 0.5-1.5 mM. Magnesium 103-112 insulin Homo sapiens 25-32 2108959-0 1990 Calcium- and magnesium-binding properties of oncomodulin. Magnesium 13-22 oncomodulin Homo sapiens 45-56 2327992-1 1990 Recent studies have shown that the platelet membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg(++)-dependent adhesion of platelets to collagen and that this adhesion is inhibited by Ca++ in a simple, linear, noncompetitive manner. Magnesium 102-108 integrin subunit alpha 2 Homo sapiens 74-79 2327992-5 1990 The results indicate that Mg++ and Ca++ stabilize different structures within the Ia-IIa (VLA-2) complex and that these structures influence both the collagen binding activity and proteolytic susceptibility of the complex. Magnesium 26-30 integrin subunit alpha 2 Homo sapiens 90-95 2157963-8 1990 Magnesium ions mimicked the effects of putrescine, suggesting the possibility that the inhibitory effects of Mg2+ and putrescine are mechanistically related. Magnesium 0-9 mucin 7, secreted Homo sapiens 109-112 2178375-6 1990 The renin-angiotensin system may also contribute to the development of magnesium deficits. Magnesium 71-80 renin Homo sapiens 4-9 2406267-6 1990 These conditions include when single-stranded DNA.SSB protein (where SSB is Escherichia coli single-stranded DNA-binding protein) complexes are formed prior to the addition of recA protein, at low magnesium ion concentration in the presence of spermidine, and at low ATP concentrations. Magnesium 197-206 single-stranded DNA-binding protein Escherichia coli 50-53 2406267-6 1990 These conditions include when single-stranded DNA.SSB protein (where SSB is Escherichia coli single-stranded DNA-binding protein) complexes are formed prior to the addition of recA protein, at low magnesium ion concentration in the presence of spermidine, and at low ATP concentrations. Magnesium 197-206 single-stranded DNA-binding protein Escherichia coli 69-72 2155777-10 1990 This demonstrates that when enough cyclin has accumulated, cdc2 kinase activation involves a protein phosphatase which must be distinct from the type 1 and 2A phosphatases, and from the calcium-dependent (type 2B) and magnesium-dependent (type 2C) phosphatases. Magnesium 218-227 proliferating cell nuclear antigen S homeolog Xenopus laevis 35-41 2155777-10 1990 This demonstrates that when enough cyclin has accumulated, cdc2 kinase activation involves a protein phosphatase which must be distinct from the type 1 and 2A phosphatases, and from the calcium-dependent (type 2B) and magnesium-dependent (type 2C) phosphatases. Magnesium 218-227 cyclin-dependent kinase 1 S homeolog Xenopus laevis 59-63 15539200-0 1990 Insulin secretion and glucose uptake in hypomagnesemic sheep fed a low magnesium, high potassium diet. Magnesium 71-80 LOC105613195 Ovis aries 0-7 2397166-5 1990 The hydrated magnesium ions, [Mg(H2O)6]2+, will most probably break important hydrogen bonds in the clusters of water (H2O)n, where n = 2, 3, 4, 5, 6.../forming new hydrogen bonds in the presence of hexa-aquated magnesium cations. Magnesium 13-22 hexosaminidase subunit alpha Homo sapiens 199-203 2155041-2 1990 The present experiments indicate that this enhancement is comparable with that produced by perfusion with an adenosine antagonist, 8-phenyltheophylline, and that superfusion with this compound or adenosine deaminase precludes any enhancement of potential size in low magnesium solutions. Magnesium 267-276 adenosine deaminase Homo sapiens 196-215 2306412-8 1990 3 Specific binding of 99mTc-NGA to human HBP in the presence of 100 microM unlabelled NGA, Ca++ and Mg++ at pH 7.5 and 37 degrees C reached 85 +/- 5% at equilibrium. Magnesium 100-104 heme binding protein 1 Homo sapiens 41-44 2329206-5 1990 Dry matter intake and milk yield were greater by cows fed MgO-supplemented than Mg chelate-supplemented treatments. Magnesium 58-60 Weaning weight-maternal milk Bos taurus 22-26 2329206-7 1990 Milk protein percentages increased with Mg chelate compared with protein percentages with MgO. Magnesium 40-42 Weaning weight-maternal milk Bos taurus 0-4 2136738-0 1990 pH and magnesium dependence of ATP binding to sarcoplasmic reticulum ATPase. Magnesium 7-16 ATPase phospholipid transporting 8A2 Homo sapiens 31-34 2136738-0 1990 pH and magnesium dependence of ATP binding to sarcoplasmic reticulum ATPase. Magnesium 7-16 dynein axonemal heavy chain 8 Homo sapiens 69-75 2136738-4 1990 When measured in the presence of calcium under otherwise similar conditions, ATPase velocity rose 4-8-fold (depending on pH and magnesium concentration) when the ATP concentration was increased from 1 microM to 0.1 mM. Magnesium 128-137 dynein axonemal heavy chain 8 Homo sapiens 77-83 2136738-4 1990 When measured in the presence of calcium under otherwise similar conditions, ATPase velocity rose 4-8-fold (depending on pH and magnesium concentration) when the ATP concentration was increased from 1 microM to 0.1 mM. Magnesium 128-137 ATPase phospholipid transporting 8A2 Homo sapiens 77-80 2136738-6 1990 Both filtration and fluorescence measurements showed that binding of metal-free ATP is independent of pH (Kd = 20-25 microM) but that the presence of magnesium induces pH dependence of the binding of the Mg.ATP complex (Kd = 10 microM at pH 6.0 and 1.5 microM at pH 8.0). Magnesium 150-159 ATPase phospholipid transporting 8A2 Homo sapiens 207-210 2136738-11 1990 The second domain of the catalytic site may bind the gamma-phosphate and the magnesium ion of the Mg.ATP complex and constitute the locus of the electrostatic interactions between the substrate and the enzyme. Magnesium 77-86 ATPase phospholipid transporting 8A2 Homo sapiens 101-104 2136738-11 1990 The second domain of the catalytic site may bind the gamma-phosphate and the magnesium ion of the Mg.ATP complex and constitute the locus of the electrostatic interactions between the substrate and the enzyme. Magnesium 98-100 ATPase phospholipid transporting 8A2 Homo sapiens 101-104 34531112-7 2022 Mg supplementation alone produced a negative effect on serum PTH levels (WMD = -236.56; 95% CI -349.71 to -123.41) and CIMT (WMD = -0.18; 95% CI -0.34 to -0.01). Magnesium 0-2 parathyroid hormone Homo sapiens 61-64 1688859-2 1990 In two-dimensional (2-D) culture systems microvascular endothelial cell proliferation is inhibited up to 80% by TGF-beta 1; however, in three-dimensional (3-D) collagen gels TGF-beta 1 is found to have no effect on proliferation while eliciting the formation of calcium and magnesium dependent tube-like structures mimicking angiogenesis. Magnesium 274-283 transforming growth factor, beta 1 Rattus norvegicus 174-184 2308874-5 1990 Ingestion of the high levels of either calcium or magnesium depressed colonic ODC activity and depressed apparent absorption of organic matter, calcium, magnesium, and phosphorus. Magnesium 50-59 ornithine decarboxylase 1 Rattus norvegicus 78-81 3888509-2 1985 The opsonic effect of MCP-1 was potentiated by Ca++ and Mg++ and was associated with binding of the peptide to alveolar macrophages and microorganisms. Magnesium 56-60 corticostatin-3 Oryctolagus cuniculus 22-27 33809914-1 2021 Magnesium-based batteries represent one of the successfully emerging electrochemical energy storage chemistries, mainly due to the high theoretical volumetric capacity of metallic magnesium (i.e., 3833 mAh cm-3 vs. 2046 mAh cm-3 for lithium), its low reduction potential (-2.37 V vs. SHE), abundance in the Earth"s crust (104 times higher than that of lithium) and dendrite-free behaviour when used as an anode during cycling. Magnesium 0-9 Src homology 2 domain containing E Homo sapiens 284-287 33804129-4 2021 We found that the highest binding interactions were found with the spike protein (6VYB), with the highest overall binding being observed with Mn-bound Methisazone at -8.3 kcal/mol, followed by Zn and Ca at -8.0 kcal/mol, and Fe and Mg at -7.9 kcal/mol. Magnesium 232-234 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 67-72 33790735-0 2021 RPL6: A Key Molecule Regulating Zinc- and Magnesium-Bound Metalloproteins of Parkinson"s Disease. Magnesium 42-51 ribosomal protein L6 Homo sapiens 0-4 33790735-10 2021 The Pearson"s correlation analysis shows that serum zinc and magnesium regulate the RPL6 gene expression in PBMC. Magnesium 61-70 ribosomal protein L6 Homo sapiens 84-88 33762953-12 2021 Inhibition of LINC01116 suppressed cell viability, migration, and invasion, along with upregulating the expression of E-cadherin, downregulating vimentin, and attenuating doxorubicin resistance in MG-63/Dox cells. Magnesium 197-199 long intergenic non-protein coding RNA 1116 Homo sapiens 14-23 33762953-12 2021 Inhibition of LINC01116 suppressed cell viability, migration, and invasion, along with upregulating the expression of E-cadherin, downregulating vimentin, and attenuating doxorubicin resistance in MG-63/Dox cells. Magnesium 197-199 ATP binding cassette subfamily B member 1 Homo sapiens 171-193 33591492-5 2022 Inflammation and cognitive-related markers (presynaptic synapsin PSD95, postsynaptic PSD93, postsynaptic GluR1, and GluR2) were improved in HFD rats administered Mg, with more significant effects seen in the MgPic group. Magnesium 162-164 discs large MAGUK scaffold protein 4 Rattus norvegicus 65-70 33591492-5 2022 Inflammation and cognitive-related markers (presynaptic synapsin PSD95, postsynaptic PSD93, postsynaptic GluR1, and GluR2) were improved in HFD rats administered Mg, with more significant effects seen in the MgPic group. Magnesium 162-164 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 105-110 33591492-5 2022 Inflammation and cognitive-related markers (presynaptic synapsin PSD95, postsynaptic PSD93, postsynaptic GluR1, and GluR2) were improved in HFD rats administered Mg, with more significant effects seen in the MgPic group. Magnesium 162-164 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 116-121 33591492-7 2022 The phosphorylation levels of Akt (Thr308), Akt (Ser473), PI3K try 458/199, and Ser9-GSK-3 in the brain were improved after Mg treatment in HFD rats, with more potent effects seen from MgPic supplementation. Magnesium 124-126 AKT serine/threonine kinase 1 Rattus norvegicus 30-33 33591492-7 2022 The phosphorylation levels of Akt (Thr308), Akt (Ser473), PI3K try 458/199, and Ser9-GSK-3 in the brain were improved after Mg treatment in HFD rats, with more potent effects seen from MgPic supplementation. Magnesium 124-126 AKT serine/threonine kinase 1 Rattus norvegicus 44-47 33591492-7 2022 The phosphorylation levels of Akt (Thr308), Akt (Ser473), PI3K try 458/199, and Ser9-GSK-3 in the brain were improved after Mg treatment in HFD rats, with more potent effects seen from MgPic supplementation. Magnesium 124-126 glycogen synthase kinase 3 alpha Rattus norvegicus 85-90 33236293-8 2021 Also, increased serum magnesium level may play a role in decreased white blood cell, neutrophil, lymphocyte cell count and increased CRP levels in the third trimester. Magnesium 22-31 C-reactive protein Homo sapiens 133-136 26082470-9 2015 FHH3 probands had significantly greater serum calcium (sCa) and magnesium (sMg) concentrations with reduced urinary calcium to creatinine clearance ratios (CCCR) in comparison with FHH1 probands with CaSR mutations, and a calculated index of sCa x sMg/100 x CCCR, which was >= 5.0, had a diagnostic sensitivity and specificity of 83 and 86%, respectively, for FHH3. Magnesium 64-73 small nuclear ribonucleoprotein polypeptide G Homo sapiens 75-78 24514589-0 2014 Synergistic restoring effects of isoproterenol and magnesium on KCNQ1-inhibited bradycardia cell models cultured in microelectrode array. Magnesium 51-60 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 64-69 22897769-8 2012 Proteinase activity was increased by Ca(2+) and Mg(2+), and inhibited by Cu(2+), Zn(2+), Cd(2+), and Fe(2+). Magnesium 48-50 endogenous retrovirus group K member 18 Homo sapiens 0-10 17804670-4 2007 A decrease in intracellular magnesium, caused by magnesium deficiency, releases the magnesium-mediated inhibition of ROMK channels and increases potassium secretion. Magnesium 28-37 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 117-121 17804670-4 2007 A decrease in intracellular magnesium, caused by magnesium deficiency, releases the magnesium-mediated inhibition of ROMK channels and increases potassium secretion. Magnesium 49-58 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 117-121 17804670-4 2007 A decrease in intracellular magnesium, caused by magnesium deficiency, releases the magnesium-mediated inhibition of ROMK channels and increases potassium secretion. Magnesium 49-58 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 117-121 1460049-13 1992 With dA3, dA1, RT, and potassium ions, CTP reduction shows absolute requirements for S-adenosylmethionine, NADPH (with NADH as a less active substitute), dithiothreitol, and magnesium ions, and is strongly stimulated by ATP, probably acting as an allosteric effector. Magnesium 174-183 A3 Drosophila melanogaster 5-8 34881568-0 2022 Optimized Magnesium Force Field Parameters for Biomolecular Simulations with Accurate Solvation, Ion-Binding, and Water-Exchange Properties in SPC/E, TIP3P-fb, TIP4P/2005, TIP4P-Ew, and TIP4P-D. Magnesium is essential in many vital processes. Magnesium 10-19 urocortin 3 Homo sapiens 143-146 34881568-0 2022 Optimized Magnesium Force Field Parameters for Biomolecular Simulations with Accurate Solvation, Ion-Binding, and Water-Exchange Properties in SPC/E, TIP3P-fb, TIP4P/2005, TIP4P-Ew, and TIP4P-D. Magnesium is essential in many vital processes. Magnesium 195-204 urocortin 3 Homo sapiens 143-146 2291515-2 1990 Infusion of ATP-MgCl2 as an adjunct following shock or ischemia significantly improves microcirculatory blood flow, tissue and mitochondrial magnesium levels, tissue ATP levels, cellular functions, and overall survival of animals. Magnesium 141-150 ATPase phospholipid transporting 8A2 Homo sapiens 12-15 2303396-7 1990 The concentrations of both Mg (P less than .10) and Fe (P less than .05) were lower in the spleen of ST lambs. Magnesium 27-29 somatotropin Ovis aries 101-103 1979999-4 1990 Glutamate-stimulated prolactin release was augmented about 4-fold by elimination of magnesium from the perfusate and was associated with stimulation of pituitary calcium flux. Magnesium 84-93 prolactin Rattus norvegicus 21-30 2132084-0 1990 Influence of magnesium supplementation on parathyroid hormone and bone Gla protein concentration in normal rats. Magnesium 13-22 parathyroid hormone Rattus norvegicus 42-61 2132084-0 1990 Influence of magnesium supplementation on parathyroid hormone and bone Gla protein concentration in normal rats. Magnesium 13-22 bone gamma-carboxyglutamate protein Rattus norvegicus 66-82 33794402-1 2021 HYPOTHESIS: It has been recently shown that, in our organism, the secretions of Ca2+, Mg2+ and phosphate ions lead to the precipitation of amorphous magnesium-calcium phosphate nanoparticles (AMCPs) in the small intestine, where the glycoprotein mucin is one of the most abundant proteins, being the main component of the mucus hydrogel layer covering gut epithelium. Magnesium 149-158 LOC100508689 Homo sapiens 246-251 33590511-1 2021 Retraction: "Magnesium protects mouse hippocampal HT22 cells against hypoxia-induced injury by upregulation of miR-221", by Fuli Mi, Fuyu Liu, Chuanzhu Zhang, Cell Biochem. Magnesium 13-22 microRNA 221 Mus musculus 111-118 33802968-0 2021 Highly Sensitive Magnesium-Doped ZnO Nanorod pH Sensors Based on Electrolyte-Insulator-Semiconductor (EIS) Sensors. Magnesium 17-26 phenylalanine hydroxylase Homo sapiens 45-47 33802968-3 2021 The results indicated that the ZnO nanorods doped with 3% Mg had a high hydrogen ion sensitivity (83.77 mV/pH), linearity (96.06%), hysteresis (3 mV), and drift (0.218 mV/h) due to the improved crystalline quality and the surface hydroxyl group role of ZnO. Magnesium 58-60 phenylalanine hydroxylase Homo sapiens 107-109 33802529-0 2021 The Relationship between the Concentration of Magnesium and the Presence of Depressive Symptoms and Selected Metabolic Disorders among Men over 50 Years of Age. Magnesium 46-55 renin binding protein Homo sapiens 156-159 34531112-11 2022 CONCLUSIONS: Our results showed that Mg supplementation alone could improve CKD-MBD by regulating serum Ca and PTH metabolism and decreasing CIMT among HD patients. Magnesium 37-39 parathyroid hormone Homo sapiens 111-114 34975721-16 2021 We conducted this study to elucidate the significance of Tr1 cells in the pathogenesis of MG. Magnesium 90-92 thioredoxin reductase 1 Homo sapiens 57-60 34919690-7 2021 Compared to wild type, Tshz3+/lacZ mice showed lower blood urea, phosphates, magnesium and potassium at 2 months of age. Magnesium 77-86 teashirt zinc finger family member 3 Mus musculus 23-28 34950419-12 2021 The impact of Mg on MT1 deserves further exploration. Magnesium 14-16 metallothionein 1 Rattus norvegicus 20-23 34890370-5 2021 RESULTS: In all studied women, the levels of IL-1beta significantly positively correlated with Ca, Mg, and Sr; IFNgamma significantly negatively correlated with Sr, and IL-6 with Mg. Magnesium 99-101 interleukin 1 alpha Homo sapiens 45-53 34890370-5 2021 RESULTS: In all studied women, the levels of IL-1beta significantly positively correlated with Ca, Mg, and Sr; IFNgamma significantly negatively correlated with Sr, and IL-6 with Mg. Magnesium 179-181 interleukin 6 Homo sapiens 169-173 34890370-8 2021 In obese women, the levels of CRP positively correlated with Zn, TNFalpha with Mg, IFNgamma with Cu and P. Magnesium 79-81 C-reactive protein Homo sapiens 30-33 34890370-8 2021 In obese women, the levels of CRP positively correlated with Zn, TNFalpha with Mg, IFNgamma with Cu and P. Magnesium 79-81 tumor necrosis factor Homo sapiens 65-73 34890370-9 2021 The levels of IL-6 negatively correlated with Ca and Mg. Magnesium 53-55 interleukin 6 Homo sapiens 14-18 34947176-4 2021 In this manuscript, a validated Computational Fluid Dynamic (CFD) model was implemented to analyze the effects of pin angle on the thermo-mechanical action during the FSW process of AA5058 Al-Mg alloy. Magnesium 192-194 dynein light chain LC8-type 1 Homo sapiens 114-117 34784661-3 2021 The players involved in magnesium reabsorption include proteins with diverse functions including tight junction proteins, cation and anion channels, sodium chloride cotransporter, calcium-sensing receptor, epidermal growth factor, cyclin M2, sodium potassium adenosine triphosphatase subunits, transcription factors, a serine protease, and proteins involved in mitochondrial function. Magnesium 24-33 calcium sensing receptor Homo sapiens 180-204 34950419-0 2021 Response of Cytoprotective and Detoxifying Proteins to Vanadate and/or Magnesium in the Rat Liver: The Nrf2-Keap1 System. Magnesium 71-80 NFE2 like bZIP transcription factor 2 Rattus norvegicus 103-107 34950419-0 2021 Response of Cytoprotective and Detoxifying Proteins to Vanadate and/or Magnesium in the Rat Liver: The Nrf2-Keap1 System. Magnesium 71-80 Kelch-like ECH-associated protein 1 Rattus norvegicus 108-113 34536830-3 2021 We investigated the potential and limits of Al2O3:C, CaF2:Mn and LiF:Mg,Cu,P detectors for such applications. Magnesium 69-71 LIF interleukin 6 family cytokine Homo sapiens 65-68 34536830-9 2021 As regards comparison of the measured and Monte Carlo calculated depth-dose profiles, the best agreement was found for LiF:Mg,Cu,P. Magnesium 123-125 LIF interleukin 6 family cytokine Homo sapiens 119-122 34536830-12 2021 For measurements related to quartz, especially for natural radiation background dose measurement, the most suitable TLDs are Al2O3:C and LiF:Mg,Cu,P. Magnesium 141-143 LIF interleukin 6 family cytokine Homo sapiens 137-140 34108639-1 2021 SPG6 accounts for 1% of autosomal dominant Hereditary Spastic Paraplegia (HSP) and is caused by pathogenic variants in NIPA1, which encodes a magnesium transporter located in plasma membrane and early endosomes, implicated in neuronal development and maintenance. Magnesium 142-151 NIPA magnesium transporter 1 Homo sapiens 0-4 34108639-1 2021 SPG6 accounts for 1% of autosomal dominant Hereditary Spastic Paraplegia (HSP) and is caused by pathogenic variants in NIPA1, which encodes a magnesium transporter located in plasma membrane and early endosomes, implicated in neuronal development and maintenance. Magnesium 142-151 NIPA magnesium transporter 1 Homo sapiens 119-124 34865947-3 2021 Expression levels of the magnesium transporters-SLC41A1, CNNM2, MAGT1, TRPM6, and TRPM7-were assessed in the peripheral leukocytes, while total calcium and magnesium were assessed in the serum between 10 and 13 weeks gestation. Magnesium 25-34 solute carrier family 41 member 1 Homo sapiens 48-55 34517107-6 2021 Here we provide an evidence that magnesium- and zinc-substituted derivatives of pheophorbide a, which are very promising photosensitizers for use in photodynamic therapy, are also recognized and transported by ABCG2. Magnesium 33-42 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 210-215 34415582-5 2021 Two Notch effector genes, hey1 and id2b, were identified that reflect bifurcation of the Notch signaling pathway, and differentially regulate MG"s injury-response threshold and proliferation of MG-derived progenitors. Magnesium 142-144 hes-related family bHLH transcription factor with YRPW motif 1 Danio rerio 26-30 34415582-5 2021 Two Notch effector genes, hey1 and id2b, were identified that reflect bifurcation of the Notch signaling pathway, and differentially regulate MG"s injury-response threshold and proliferation of MG-derived progenitors. Magnesium 142-144 inhibitor of DNA binding 2b Danio rerio 35-39 34415582-6 2021 Furthermore, Notch signaling component gene repression in the injured retina suggests a role for Dll4, Dlb, and Notch3 in regulating Notch signaling in MG and epistasis experiments confirm that the Dll4/Dlb-Notch3-Hey1/Id2b signaling pathway regulates MG"s injury-response threshold and proliferation. Magnesium 152-154 notch receptor 3 Danio rerio 133-138 34784661-3 2021 The players involved in magnesium reabsorption include proteins with diverse functions including tight junction proteins, cation and anion channels, sodium chloride cotransporter, calcium-sensing receptor, epidermal growth factor, cyclin M2, sodium potassium adenosine triphosphatase subunits, transcription factors, a serine protease, and proteins involved in mitochondrial function. Magnesium 24-33 epidermal growth factor Homo sapiens 206-229 34857271-0 2021 Mg-Fe layered double hydroxides modified titanium enhanced the adhesion of human gingival fibroblasts through regulation of local pH level. Magnesium 0-2 phenylalanine hydroxylase Homo sapiens 130-132 34784661-3 2021 The players involved in magnesium reabsorption include proteins with diverse functions including tight junction proteins, cation and anion channels, sodium chloride cotransporter, calcium-sensing receptor, epidermal growth factor, cyclin M2, sodium potassium adenosine triphosphatase subunits, transcription factors, a serine protease, and proteins involved in mitochondrial function. Magnesium 24-33 cyclin and CBS domain divalent metal cation transport mediator 2 Homo sapiens 231-240 34784661-3 2021 The players involved in magnesium reabsorption include proteins with diverse functions including tight junction proteins, cation and anion channels, sodium chloride cotransporter, calcium-sensing receptor, epidermal growth factor, cyclin M2, sodium potassium adenosine triphosphatase subunits, transcription factors, a serine protease, and proteins involved in mitochondrial function. Magnesium 24-33 coagulation factor II, thrombin Homo sapiens 319-334 34788022-9 2021 Moreover, isomeric identification among GT1a, GT1b, and GT1c was accomplished while performing a gas-phase magnesium transfer reaction and CID. Magnesium 107-116 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 97-100 34899793-3 2021 Recently, we discovered that phospholipase Dalpha1 (PLDalpha1) activity is vital in the stress response to high-magnesium conditions in Arabidopsis roots. Magnesium 112-121 DA1 Arabidopsis thaliana 43-50 34837716-5 2021 Previously we have showed that GTPase activity of FtsY is metal ion dependent and showed the maximum activity with 10mM magnesium. Magnesium 120-129 signal recognition particle-docking protein FtsY Mycolicibacterium smegmatis MC2 155 50-54 34899793-7 2021 In pldalpha1-1 plants, higher accumulation of abscisic and jasmonic acid (JA) and impaired magnesium, potassium and phosphate homeostasis were observed under high-Mg2+ conditions. Magnesium 91-100 phospholipase D alpha 1 Arabidopsis thaliana 3-14 34899793-3 2021 Recently, we discovered that phospholipase Dalpha1 (PLDalpha1) activity is vital in the stress response to high-magnesium conditions in Arabidopsis roots. Magnesium 112-121 phospholipase D alpha 1 Arabidopsis thaliana 52-61 34868726-4 2021 We describe the first reported successful response to anti-SARS-CoV-2 S antibody post-vaccination in magnesium transporter 1 (MAGT1) gene deficiency, more commonly recognized as x-linked immunodeficiency with magnesium defect, Epstein-Barr Virus infection, and neoplasia (XMEN). Magnesium 209-218 magnesium transporter 1 Homo sapiens 101-124 34868726-4 2021 We describe the first reported successful response to anti-SARS-CoV-2 S antibody post-vaccination in magnesium transporter 1 (MAGT1) gene deficiency, more commonly recognized as x-linked immunodeficiency with magnesium defect, Epstein-Barr Virus infection, and neoplasia (XMEN). Magnesium 209-218 magnesium transporter 1 Homo sapiens 126-131 34787834-4 2021 Serum Ca, Mg, and Ca/Mg ratio tended to have positive associations with ApoA1, while negative associations of serum Ca, Mg, and Ca/Mg ratio with ApoB and ApoB/A1 ratio were detected. Magnesium 120-122 apolipoprotein B Homo sapiens 145-149 34885294-3 2021 In 0.6 mol/L NaCl and Na2SO4 solutions, the microgalvanic corrosion behavior of the second phase and Mg matrix of Mg-Ca and Mg-Al-Ca alloys was examined. Magnesium 101-103 attractin Homo sapiens 114-119 34787834-4 2021 Serum Ca, Mg, and Ca/Mg ratio tended to have positive associations with ApoA1, while negative associations of serum Ca, Mg, and Ca/Mg ratio with ApoB and ApoB/A1 ratio were detected. Magnesium 10-12 apolipoprotein A1 Homo sapiens 72-77 34787834-4 2021 Serum Ca, Mg, and Ca/Mg ratio tended to have positive associations with ApoA1, while negative associations of serum Ca, Mg, and Ca/Mg ratio with ApoB and ApoB/A1 ratio were detected. Magnesium 21-23 apolipoprotein A1 Homo sapiens 72-77 34774073-0 2021 Correction to: Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced cystitis by inhibiting TNF-alpha/NF-kappaB signaling in female rats. Magnesium 32-41 tumor necrosis factor Rattus norvegicus 197-206 34761296-12 2022 Low/normal serum Mg levels suggested the diagnosis of FHHNC which was confirmed genetically as a homozygous missense (c.602G > A; p.G201E) variant in CLDN16. Magnesium 17-19 claudin 16 Homo sapiens 150-156 34828365-3 2021 The cipk3/9/23/26 quadruple mutant is very sensitive to high levels of magnesium. Magnesium 71-80 CBL-interacting protein kinase 3 Arabidopsis thaliana 4-14 34828365-4 2021 In this study, TMT quantitative phosphoproteomics were used to compare the global variations in phosphoproteins in wild type and cipk3/9/23/26 quadruple mutant seedlings of Arabidopsis thaliana, and 12,506 phosphorylation modification sites on 4537 proteins were identified, of which 773 phosphorylated proteins exhibited significant variations at the phosphorylation level under magnesium sensitivity. Magnesium 380-389 CBL-interacting protein kinase 3 Arabidopsis thaliana 129-139 34828365-7 2021 The results of this study further our understanding of the molecular mechanisms of CIPK3/9/23/26 in mediating magnesium homeostasis. Magnesium 110-119 CBL-interacting protein kinase 3 Arabidopsis thaliana 83-96 34652134-1 2021 Sodium reduction of ({SiNDipp}Mg) ({SiNDipp} = {CH2SiMe2N(Dipp)}2; Dipp = 2,6-i-Pr2C6H3) provides the Mg(I) species, ({SiNDipp}MgNa)2, in which the long Mg-Mg bond (>3.2 A) is augmented by persistent Na-aryl interactions. Magnesium 153-155 nudix hydrolase 3 Homo sapiens 58-62 34652134-1 2021 Sodium reduction of ({SiNDipp}Mg) ({SiNDipp} = {CH2SiMe2N(Dipp)}2; Dipp = 2,6-i-Pr2C6H3) provides the Mg(I) species, ({SiNDipp}MgNa)2, in which the long Mg-Mg bond (>3.2 A) is augmented by persistent Na-aryl interactions. Magnesium 156-158 nudix hydrolase 3 Homo sapiens 58-62 34699176-6 2021 In situ high-resolution TEM observations of the decomposition process together with other analyses revealed that the nanosize effect caused by the nanoconfinement and the multiphasic interfaces between MgH2(Mg) and Ti-MX, especially the in situ formed catalytic TiH2, were main reasons accounting for the superior hydrogen sorption performances. Magnesium 207-209 RuvB like AAA ATPase 2 Homo sapiens 262-266 34586571-0 2021 Mean-field theory of the interaction of the magnesium ion with biopolymers: the case of lysozyme. Magnesium 44-53 lysozyme Homo sapiens 88-96 34586571-1 2021 A statistical theory is presented of the magnesium ion interacting with lysozyme under conditions where the latter is positively charged. Magnesium 41-50 lysozyme Homo sapiens 72-80 34836329-7 2021 Furthermore, Mg supplementation demonstrated an improvement in insulin sensitivity markers. Magnesium 13-15 insulin Homo sapiens 63-70 34836329-9 2021 Moreover, our work indicates that Mg supplementation may improve insulin-sensitivity parameters in those at high risk of diabetes. Magnesium 34-36 insulin Homo sapiens 65-72 34836340-3 2021 Administration of sodium-glucose transporter 2 (SGLT2) inhibitors has been reported to increase serum magnesium levels in patients with diabetes. Magnesium 102-111 solute carrier family 5 member 2 Homo sapiens 18-46 34836340-3 2021 Administration of sodium-glucose transporter 2 (SGLT2) inhibitors has been reported to increase serum magnesium levels in patients with diabetes. Magnesium 102-111 solute carrier family 5 member 2 Homo sapiens 48-53 34836340-7 2021 Dapagliflozin treatment improved insulin resistance by decreasing glucose and insulin levels, increased serum magnesium levels, and reduced urinary magnesium excretion. Magnesium 110-119 insulin Homo sapiens 33-40 34836340-7 2021 Dapagliflozin treatment improved insulin resistance by decreasing glucose and insulin levels, increased serum magnesium levels, and reduced urinary magnesium excretion. Magnesium 148-157 insulin Homo sapiens 33-40 34836340-8 2021 Serum vitamin D and parathyroid hormone levels were decreased in fructose-fed animals, and the levels remained low despite dapagliflozin and magnesium supplementation. Magnesium 141-150 parathyroid hormone Homo sapiens 20-39 34836340-10 2021 Dapagliflozin increased intracellular magnesium concentration, and this effect was inhibited by TRPM6 blockade and the EGFR antagonist. Magnesium 38-47 transient receptor potential cation channel subfamily M member 6 Homo sapiens 96-101 34836340-10 2021 Dapagliflozin increased intracellular magnesium concentration, and this effect was inhibited by TRPM6 blockade and the EGFR antagonist. Magnesium 38-47 epidermal growth factor receptor Homo sapiens 119-123 34836340-14 2021 Dapagliflozin enhances TRPM6-mediated trans-epithelial magnesium transport in renal tubule cells. Magnesium 55-64 transient receptor potential cation channel subfamily M member 6 Homo sapiens 23-28 34768309-7 2022 Calcium and magnesium reduce the conductance of both stoichiometric forms, with each cation producing an equivalent reduction, but the reduction is greater for the (alpha4)2 (beta2)3 form. Magnesium 12-21 glycoprotein hormone subunit alpha 2 Homo sapiens 165-182 34768309-9 2022 For the (alpha4)3 (beta2)2 stoichiometry, at high but not low ACh concentrations, calcium in synergy with magnesium promote clustering of channel openings into episodes of many openings in quick succession. Magnesium 106-115 glycoprotein hormone subunit alpha 2 Homo sapiens 19-24 34749737-0 2021 The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection. Magnesium 25-34 interferon None 59-69 34749737-5 2021 In addition, it has been indicated that some nutrients, including vitamin D, magnesium and zinc are essential in the modulation of the immune system and interferon (IFN) signaling pathway. Magnesium 77-86 interferon alpha 1 Homo sapiens 165-168 34749737-7 2021 In the present study, the synergistic action of vitamin D, magnesium and zinc in IFN signaling is discussed as a treatment option for COVID-19 involvement. Magnesium 59-68 interferon alpha 1 Homo sapiens 81-84 34822420-2 2021 This study aims to investigate the contribution of magnesium-restriction to the development of NAFLD. Magnesium 51-60 TSC complex subunit 2 Mus musculus 95-100 34822420-10 2021 Furthermore, magnesium-restricted and high-fat-diet fed mice exhibited elevated hepatic TNFalpha levels compared to control mice. Magnesium 13-22 tumor necrosis factor Mus musculus 88-96 34822420-11 2021 Accordingly, our data suggest that magnesium is involved in hepatic inflammatory processes and hepatocyte enlargement, key histological features of human NAFLD, and may therefore contribute to development and progression of the disease. Magnesium 35-44 TSC complex subunit 2 Mus musculus 154-159 34828365-1 2021 CBL-interacting protein kinases 3/9/23/26 (CIPK3/9/23/26) are central regulation components of magnesium ion homeostasis. Magnesium 95-104 CBL-interacting protein kinase 3 Arabidopsis thaliana 43-56 34463339-1 2021 The cooling rate to room temperature following the 400 C pre-irradiation anneal is known to affect the thermoluminescent properties of LiF:Mg,Ti (TLD-100) as a result of migration and clustering of defects during the cooling down process. Magnesium 139-141 LIF interleukin 6 family cytokine Homo sapiens 135-138 34492244-0 2021 Vitamin D3/vitamin K2/magnesium-loaded polylactic acid/tricalcium phosphate/polycaprolactone composite nanofibers demonstrated osteoinductive effect by increasing Runx2 via Wnt/B-catenin pathway. Magnesium 22-31 RUNX family transcription factor 2 Homo sapiens 163-168 34492244-0 2021 Vitamin D3/vitamin K2/magnesium-loaded polylactic acid/tricalcium phosphate/polycaprolactone composite nanofibers demonstrated osteoinductive effect by increasing Runx2 via Wnt/B-catenin pathway. Magnesium 22-31 catenin beta 1 Homo sapiens 177-186 34492244-4 2021 Vitamin D3, vitamin K2, and magnesium demonstrated to support the osteogenic differentiation of mesenchymal stem cells by expressing Runx2, BMP2, and osteopontin and suppressing PPAR-gamma and Sox9. Magnesium 28-37 RUNX family transcription factor 2 Homo sapiens 133-138 34492244-4 2021 Vitamin D3, vitamin K2, and magnesium demonstrated to support the osteogenic differentiation of mesenchymal stem cells by expressing Runx2, BMP2, and osteopontin and suppressing PPAR-gamma and Sox9. Magnesium 28-37 bone morphogenetic protein 2 Homo sapiens 140-144 34492244-4 2021 Vitamin D3, vitamin K2, and magnesium demonstrated to support the osteogenic differentiation of mesenchymal stem cells by expressing Runx2, BMP2, and osteopontin and suppressing PPAR-gamma and Sox9. Magnesium 28-37 secreted phosphoprotein 1 Homo sapiens 150-161 34492244-4 2021 Vitamin D3, vitamin K2, and magnesium demonstrated to support the osteogenic differentiation of mesenchymal stem cells by expressing Runx2, BMP2, and osteopontin and suppressing PPAR-gamma and Sox9. Magnesium 28-37 peroxisome proliferator activated receptor gamma Homo sapiens 178-188 34492244-4 2021 Vitamin D3, vitamin K2, and magnesium demonstrated to support the osteogenic differentiation of mesenchymal stem cells by expressing Runx2, BMP2, and osteopontin and suppressing PPAR-gamma and Sox9. Magnesium 28-37 SRY-box transcription factor 9 Homo sapiens 193-197 34716795-4 2021 In particular, when the doping concentration reaches to 14.29%, the adsorption energies of Mg on Mo2C0.875N0.125 are in the region between -1.639 and -1.517 eV, e.g., the adsorption energies of Mg on TC1 and H2 sites are -1.639 eV and -1.625 eV, which are decreased by 16.49% and 18.43% as compared with the pristine Mo2C. Magnesium 91-93 transcriptional and immune response regulator Homo sapiens 200-203 34787834-4 2021 Serum Ca, Mg, and Ca/Mg ratio tended to have positive associations with ApoA1, while negative associations of serum Ca, Mg, and Ca/Mg ratio with ApoB and ApoB/A1 ratio were detected. Magnesium 131-133 apolipoprotein B Homo sapiens 145-149 34787834-4 2021 Serum Ca, Mg, and Ca/Mg ratio tended to have positive associations with ApoA1, while negative associations of serum Ca, Mg, and Ca/Mg ratio with ApoB and ApoB/A1 ratio were detected. Magnesium 131-133 apolipoprotein B Homo sapiens 154-158 34787834-5 2021 In multivariate analysis, serum Ca, Mg, and Ca/Mg ratio were positively associated with ApoA1 levels (Q (quintile) 5 vs. Q1: 1.245 vs. 1.151 g/L for Ca, 1.207 vs. 1.188 g/L for Mg, 1.202 vs. 1.171 g/L for Ca/Mg ratio). Magnesium 36-38 apolipoprotein A1 Homo sapiens 88-93 34787834-5 2021 In multivariate analysis, serum Ca, Mg, and Ca/Mg ratio were positively associated with ApoA1 levels (Q (quintile) 5 vs. Q1: 1.245 vs. 1.151 g/L for Ca, 1.207 vs. 1.188 g/L for Mg, 1.202 vs. 1.171 g/L for Ca/Mg ratio). Magnesium 47-49 apolipoprotein A1 Homo sapiens 88-93 34787834-6 2021 In contrast, negative associations of serum Mg and Ca/Mg ratio with ApoB and ApoB/A1 ratio were shown. Magnesium 44-46 apolipoprotein B Homo sapiens 68-72 34787834-6 2021 In contrast, negative associations of serum Mg and Ca/Mg ratio with ApoB and ApoB/A1 ratio were shown. Magnesium 44-46 apolipoprotein B Homo sapiens 77-81 34787834-6 2021 In contrast, negative associations of serum Mg and Ca/Mg ratio with ApoB and ApoB/A1 ratio were shown. Magnesium 54-56 apolipoprotein B Homo sapiens 68-72 34787834-6 2021 In contrast, negative associations of serum Mg and Ca/Mg ratio with ApoB and ApoB/A1 ratio were shown. Magnesium 54-56 apolipoprotein B Homo sapiens 77-81 34787834-10 2021 In summary, serum Ca and Mg tended to have positive associations with ApoA1 levels in patients with CAD, but had inverse associations with ApoB levels and ApoB/A1 ratio. Magnesium 25-27 apolipoprotein A1 Homo sapiens 70-75 34289421-14 2021 Sufficient mechanical properties, biocompatibility with Schwan cells and good performance after sciatic nerve transplantation demonstrates that the S/Mg-SF/CS NGC in this study promotes the growth of damaged nerves and provides a suitable physio-mechanical guide for potential in artificial nerve transplantation. Magnesium 150-152 citrate synthase Rattus norvegicus 156-158 34787834-10 2021 In summary, serum Ca and Mg tended to have positive associations with ApoA1 levels in patients with CAD, but had inverse associations with ApoB levels and ApoB/A1 ratio. Magnesium 25-27 apolipoprotein B Homo sapiens 139-143 34411605-14 2021 As a result, magnesium may have beneficial effects on IR by increasing the expression of IRS1, Akt and GLUT4 genes. Magnesium 13-22 insulin receptor substrate 1 Rattus norvegicus 89-93 34411605-14 2021 As a result, magnesium may have beneficial effects on IR by increasing the expression of IRS1, Akt and GLUT4 genes. Magnesium 13-22 AKT serine/threonine kinase 1 Rattus norvegicus 95-98 34411605-14 2021 As a result, magnesium may have beneficial effects on IR by increasing the expression of IRS1, Akt and GLUT4 genes. Magnesium 13-22 solute carrier family 2 member 4 Rattus norvegicus 103-108 34704011-0 2021 Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway. Magnesium 14-23 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 121-125 34704011-0 2021 Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway. Magnesium 14-23 mechanistic target of rapamycin kinase Homo sapiens 126-130 34704011-0 2021 Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway. Magnesium 14-23 unc-51 like autophagy activating kinase 1 Homo sapiens 131-135 34640291-4 2021 The HA nanofibers and the MgP nanosheets were synthesized using a hydrothermal homogeneous precipitation method and tuning the crystallization of the sodium-magnesium-phosphate ternary system, respectively. Magnesium 157-166 matrix Gla protein Homo sapiens 26-29 34692745-7 2021 In the group receiving PN under the supervision of a dietician, the level of serum Cr (1.23 vs. 1.32, P = 0.04), Mg (2.07 vs. 1.84, P < 0.01), and pH (7.45 vs. 7.5, P = 0.03) significantly improved after receiving parenteral nutrition compared to baseline. Magnesium 113-115 U6 snRNA biogenesis phosphodiesterase 1 Homo sapiens 23-25 34901527-8 2022 The cellular activities of human TERT-immortalized mesenchymal stem cells on the Mg-enriched grafts were notably upregulated. Magnesium 81-83 telomerase reverse transcriptase Homo sapiens 33-37 34606706-10 2021 Amylase level, MDA, MPO, and NO were significantly higher in the AP group than in the control but decreased in Mg and MO groups. Magnesium 111-113 myeloperoxidase Rattus norvegicus 20-23 34392046-5 2021 SNP further restored the growth retardation through modulating the chlorophyll and proline metabolism, increasing NO accumulation and stomatal conductance along with clear crosstalk between the antioxidant activity as well as glyoxalase I and II leading to endogenous H2O2 and MG reduction. Magnesium 277-279 lactoylglutathione lyase Solanum lycopersicum 226-245 34296452-0 2021 CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway. Magnesium 31-40 Eph receptor B1 Rattus norvegicus 117-120 34296452-12 2021 Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway. Magnesium 55-64 Eph receptor B1 Rattus norvegicus 139-142 34235777-7 2021 As the serum magnesium level is known to be reduced by the inhibition of EGFR, a similar mechanism may also be involved in decreasing the serum zinc level. Magnesium 13-22 epidermal growth factor receptor Homo sapiens 73-77 34252449-4 2021 Consistent with the hypomagnesemia, CnB1-KO mice showed a downregulation of proteins implicated in DCT magnesium transport, including TRPM6, CNNM2, SLC41A3 and parvalbumin but expression of calcium channel TRPV5 in the kidney was unchanged. Magnesium 103-112 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) Mus musculus 36-40 34382282-2 2021 Recently, GUN4 has been found to be able to bind the linear tetrapyrroles (bilins) and stimulate the magnesium chelatase activity in the unicellular green alga C. reinhardtii. Magnesium 101-110 protein GENOMES UNCOUPLED 4 Arabidopsis thaliana 10-14 34683244-0 2021 Improvement in Hydriding and Dehydriding Features of Mg-TaF5-VCl3 Alloy by Adding Ni and x wt% MgH2 (x = 1, 5, and 10) Together with TaF5 and VCl3. Magnesium 53-55 TATA-box binding protein associated factor 5 Homo sapiens 56-60 34927937-2 2021 Herein, a practical solution is presented to recover and increase the stability of the layered structure from scrap Li1- x CoO2 via high-temperature supplementation of Li and Mg doping, without an extra synthesis step or cost. Magnesium 175-177 transglutaminase 1 Homo sapiens 116-119 34703991-5 2021 The protein-protein interaction network demonstrated an interaction between the serum magnesium-associated gene DCDC1 and the cataract- associated gene PAX6. Magnesium 86-95 doublecortin domain containing 1 Homo sapiens 112-117 34703991-5 2021 The protein-protein interaction network demonstrated an interaction between the serum magnesium-associated gene DCDC1 and the cataract- associated gene PAX6. Magnesium 86-95 paired box 6 Homo sapiens 152-156 34703991-7 2021 The DCDC1 gene and the PAX6 gene may be the new targets for promoting the treatments of cataracts using magnesium intervention. Magnesium 104-113 doublecortin domain containing 1 Homo sapiens 4-9 34703991-7 2021 The DCDC1 gene and the PAX6 gene may be the new targets for promoting the treatments of cataracts using magnesium intervention. Magnesium 104-113 paired box 6 Homo sapiens 23-27 34683244-0 2021 Improvement in Hydriding and Dehydriding Features of Mg-TaF5-VCl3 Alloy by Adding Ni and x wt% MgH2 (x = 1, 5, and 10) Together with TaF5 and VCl3. Magnesium 53-55 TATA-box binding protein associated factor 5 Homo sapiens 133-137 34683244-2 2021 In this work, Ni was added together with TaF5 and VCl3 to increase the reaction rates with hydrogen and the hydrogen-storage capacity of Mg. Magnesium 137-139 TATA-box binding protein associated factor 5 Homo sapiens 41-45 34639491-11 2021 High correlation coefficients (r >= 0.8) were found for the elements Mg, Ca, Fe, Al, Cd, Pb, and Zn in the PM1 fraction, Cd, Pb, and Zn in PM2.5, and Ba, Sb, Fe, Cu, Cr, Mg, Al, and Ca in PM2.5-10. Magnesium 69-71 transmembrane protein 11 Homo sapiens 107-110 34660198-0 2021 Immobilization of bioactive vascular endothelial growth factor onto Ca-deficient hydroxyapatite-coated Mg by covalent bonding using polydopamine. Magnesium 103-105 vascular endothelial growth factor A Rattus norvegicus 28-62 34660198-8 2021 VEGF could be firmly immobilized on Mg via polydopamine. Magnesium 36-38 vascular endothelial growth factor A Rattus norvegicus 0-4 34660198-9 2021 The CCK-8, live/dead staining and adhesion test results showed that the VEGF-DOPA-CDHA coating exhibited excellent biocompatibility and could significantly improve the adhesion and proliferation of MC3T3-E1 cells on Mg. Microtubule formation, immunofluorescence and Quantitative Real-Time PCR (qRT-PCR) experiments showed that VEGF immobilized on Mg still possessed bioactivity in promoting the differentiation of rat mesenchymal stem cells into endothelial cells. Magnesium 347-349 vascular endothelial growth factor A Rattus norvegicus 327-331 34660198-10 2021 Conclusion: In this study, we enabled the angiogenic biological activity of Mg by immobilizing VEGF on Mg. Mg was successfully coated with a functional VEGF-DOPA-CDHA composite coating. Magnesium 76-78 vascular endothelial growth factor A Rattus norvegicus 95-99 34660198-10 2021 Conclusion: In this study, we enabled the angiogenic biological activity of Mg by immobilizing VEGF on Mg. Mg was successfully coated with a functional VEGF-DOPA-CDHA composite coating. Magnesium 76-78 vascular endothelial growth factor A Rattus norvegicus 152-156 34660198-11 2021 The CDHA coating significantly increased the corrosion resistance of Mg and prohibited the negative effect of excessively high local alkalinity on the biological activity of VEGF. Magnesium 69-71 vascular endothelial growth factor A Rattus norvegicus 174-178 34660198-16 2021 In this study, VEGF was connected on the surface of degradable magnesium by covalent bonding. Magnesium 63-72 vascular endothelial growth factor A Rattus norvegicus 15-19 34639908-4 2021 The primary Al3(Sc1-xZrx) phase promotes recrystallization due to particle-stimulated nucleation (PSN), and acts as the cathode to stimulate an accelerated electrochemical process between the primary Al3(Sc1-xZrx) particles and GBPs, resulting in a sharp decrease of the corrosion resistance in the surface layer of Al-Zn-Mg-Cu-Sc-Zr alloy. Magnesium 322-324 transcription factor 19 Homo sapiens 16-19 34469538-4 2021 By investigation of the AC-motif present in the CDKL3 promoter (AC-motifCDKL3), one of AC-motifs found in the genome, we confirmed that AC-motifCDKL3 has a key role in regulating CDKL3 gene expression in response to magnesium. Magnesium 216-225 cyclin dependent kinase like 3 Homo sapiens 48-53 34469538-4 2021 By investigation of the AC-motif present in the CDKL3 promoter (AC-motifCDKL3), one of AC-motifs found in the genome, we confirmed that AC-motifCDKL3 has a key role in regulating CDKL3 gene expression in response to magnesium. Magnesium 216-225 cyclin dependent kinase like 3 Homo sapiens 179-184 34639908-4 2021 The primary Al3(Sc1-xZrx) phase promotes recrystallization due to particle-stimulated nucleation (PSN), and acts as the cathode to stimulate an accelerated electrochemical process between the primary Al3(Sc1-xZrx) particles and GBPs, resulting in a sharp decrease of the corrosion resistance in the surface layer of Al-Zn-Mg-Cu-Sc-Zr alloy. Magnesium 322-324 transcription factor 19 Homo sapiens 204-207 34544421-4 2021 RESULTS: Our study shows that Irf8-deficient MG exhibit a considerable loss of microglial signature genes accompanied by a severely altered MG morphology. Magnesium 140-142 interferon regulatory factor 8 Mus musculus 30-34 34545866-7 2021 Besides, the sensing range of the PDs can be tuned from visible (650 nm) to NIR (782 nm) with a huge improvement in selectivity by incorporation of Mg. Magnesium 148-150 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 76-79 34544421-6 2021 However, in the laser-induced CNV model, Irf8-deficient microglia showed an increased activity of biological processes critical for inflammation and cell adhesion and a reduced MG cell density near the lesions, which was associated with significantly increased CNV lesion size. Magnesium 177-179 interferon regulatory factor 8 Mus musculus 41-45 34576563-5 2021 In contrast with the compensation of nitrogen vacancy in p-type InGaN grown in a Ga-rich environment, the holes in p-type InGaN grown in an N-rich environment were mainly compensated by interstitial Mg (Mgi), which has very low formation energy. Magnesium 199-201 CMS1A1 Homo sapiens 203-206 34537919-0 2021 Relationship Between Serum Magnesium Level and Insulin Resistance in Turkey Non-obese Adult Population. Magnesium 27-36 insulin Meleagris gallopavo 47-54 34537919-2 2021 In particular, magnesium (Mg) is an extensively studied mineral that has been shown to function in the management of hyperglycemia and insulin resistance (IR) action. Magnesium 15-24 insulin Homo sapiens 135-142 34537919-2 2021 In particular, magnesium (Mg) is an extensively studied mineral that has been shown to function in the management of hyperglycemia and insulin resistance (IR) action. Magnesium 26-28 insulin Homo sapiens 135-142 34574240-11 2021 Pasta is an important source of Mg, Cu, and Mn in the diet of Poles. Magnesium 32-34 solute carrier family 45 member 1 Homo sapiens 0-5 34416738-2 2021 In this research, the nanocomposite coatings of Chitosan (CS)/graphene oxide (GO) were fabricated to improve the corrosion resistance of the Mg-2wt% Zn scaffold. Magnesium 141-143 citrate synthase Homo sapiens 48-56 34416738-2 2021 In this research, the nanocomposite coatings of Chitosan (CS)/graphene oxide (GO) were fabricated to improve the corrosion resistance of the Mg-2wt% Zn scaffold. Magnesium 141-143 citrate synthase Homo sapiens 58-60 34382634-9 2021 The in vivo experimental results showed that the Ba/Mg@HA/PLGA composites significantly increased the rate of bone defect healing and the expression of BMP-2 and COL-1 in the bones of rats. Magnesium 52-54 bone morphogenetic protein 2 Rattus norvegicus 152-157 34539327-9 2021 ATP2C2 encodes a magnesium-dependent calcium transporter which fits with reports about disturbed calcium and magnesium levels for dyslexia and other communication disorders. Magnesium 17-26 ATPase secretory pathway Ca2+ transporting 2 Homo sapiens 0-6 34539327-9 2021 ATP2C2 encodes a magnesium-dependent calcium transporter which fits with reports about disturbed calcium and magnesium levels for dyslexia and other communication disorders. Magnesium 109-118 ATPase secretory pathway Ca2+ transporting 2 Homo sapiens 0-6 34484805-3 2021 In this study, Mg-CPS showed better osteogenic and angiogenic properties than CPS within 10 wt.% magnesium oxide (MgO), since the adversity of alkaline condition was covered by the benefits of improved Mg ion concentrations through activating Smad2/3-Runx2 signaling pathway in MC3T3-E1 cells and PI3K-AKT signaling pathway in human umbilical vein endothelial cells in vitro. Magnesium 202-204 SMAD family member 2 Mus musculus 243-250 34484805-3 2021 In this study, Mg-CPS showed better osteogenic and angiogenic properties than CPS within 10 wt.% magnesium oxide (MgO), since the adversity of alkaline condition was covered by the benefits of improved Mg ion concentrations through activating Smad2/3-Runx2 signaling pathway in MC3T3-E1 cells and PI3K-AKT signaling pathway in human umbilical vein endothelial cells in vitro. Magnesium 202-204 runt related transcription factor 2 Mus musculus 251-256 34144340-3 2021 It was found that these dosimeters show a sensitivity approximately 10 times higher than that shown by the commercial dosimeter TLD-100 (LiF:Mg,Ti). Magnesium 141-143 LIF interleukin 6 family cytokine Homo sapiens 137-140 34697742-5 2021 Phosphorylation of AMPKalpha, expression of p21 and replication of mtDNA was also promoted in MG-63 and U2-OS cells on treatment with IXNP. Magnesium 94-96 H3 histone pseudogene 16 Homo sapiens 44-47 34116393-0 2021 Magnesium treatment on methylation changes of transmembrane serine protease 2 (TMPRSS2). Magnesium 0-9 transmembrane serine protease 2 Homo sapiens 46-77 34116393-0 2021 Magnesium treatment on methylation changes of transmembrane serine protease 2 (TMPRSS2). Magnesium 0-9 transmembrane serine protease 2 Homo sapiens 79-86 34116393-2 2021 This study aims to test the hypothesis that magnesium (Mg) treatment leads to DNA methylation changes in TMPRSS2. Magnesium 44-53 transmembrane serine protease 2 Homo sapiens 105-112 34116393-2 2021 This study aims to test the hypothesis that magnesium (Mg) treatment leads to DNA methylation changes in TMPRSS2. Magnesium 55-57 transmembrane serine protease 2 Homo sapiens 105-112 34116393-8 2021 CONCLUSIONS: Among individuals ages < 65 y with calcium-to-magnesium intake ratios equal to or over 2.6, reducing the ratio to around 2.3 increased 5-methylcytosine modifications (i.e., cg16371860) and reduced 5-hydroxymethylcytosine modifications (i.e., cg26337277) in the TMPRSS2 gene. Magnesium 59-68 transmembrane serine protease 2 Homo sapiens 274-281 34528380-5 2022 In this scenario, syn-glacial seawater chemistry should instead be dominated by chemical exchange with the oceanic crust and volcanic systems, developing low pH and low Mg/Ca ratios. Magnesium 169-171 synemin Homo sapiens 18-21 34484559-12 2021 Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1. Magnesium 146-148 kelch-like ECH-associated protein 1 Mus musculus 18-23 34484559-12 2021 Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1. Magnesium 146-148 nuclear factor, erythroid derived 2, like 2 Mus musculus 24-28 34484559-12 2021 Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1. Magnesium 146-148 heme oxygenase 1 Mus musculus 29-33 34484559-12 2021 Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1. Magnesium 146-148 nuclear factor, erythroid derived 2, like 2 Mus musculus 191-195 34484559-12 2021 Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1. Magnesium 146-148 heme oxygenase 1 Mus musculus 200-204 34484559-12 2021 Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1. Magnesium 146-148 kelch-like ECH-associated protein 1 Mus musculus 224-229 34484559-12 2021 Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1. Magnesium 146-148 NAD(P)H dehydrogenase, quinone 1 Mus musculus 321-325 34484559-12 2021 Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1. Magnesium 146-148 glutamate-cysteine ligase, catalytic subunit Mus musculus 327-331 34484559-12 2021 Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1. Magnesium 146-148 catalase Mus musculus 333-336 34484559-12 2021 Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1. Magnesium 146-148 GS homeobox 1 Mus musculus 342-346 34484559-13 2021 Our findings indicated that MG-Exos exerted an antioxidant effect and positively modulated vascular regeneration and neurological functional recovery post-SCI by activating keap1/Nrf2/HO-1 signaling. Magnesium 28-30 kelch-like ECH-associated protein 1 Mus musculus 173-178 34484559-13 2021 Our findings indicated that MG-Exos exerted an antioxidant effect and positively modulated vascular regeneration and neurological functional recovery post-SCI by activating keap1/Nrf2/HO-1 signaling. Magnesium 28-30 nuclear factor, erythroid derived 2, like 2 Mus musculus 179-183 34484559-13 2021 Our findings indicated that MG-Exos exerted an antioxidant effect and positively modulated vascular regeneration and neurological functional recovery post-SCI by activating keap1/Nrf2/HO-1 signaling. Magnesium 28-30 heme oxygenase 1 Mus musculus 184-188 34490037-2 2021 Cyclin M2 (CNNM2) proteins, as a member of magnesium (Mg2+) transporters, were found along the basolateral membrane of distal renal tubules and involved in the reabsorption of Mg2+. Magnesium 43-52 cyclin and CBS domain divalent metal cation transport mediator 2 Homo sapiens 0-9 34490037-2 2021 Cyclin M2 (CNNM2) proteins, as a member of magnesium (Mg2+) transporters, were found along the basolateral membrane of distal renal tubules and involved in the reabsorption of Mg2+. Magnesium 43-52 cyclin and CBS domain divalent metal cation transport mediator 2 Homo sapiens 11-16 34820578-0 2022 Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis. Magnesium 50-59 transformation related protein 53, pseudogene Mus musculus 68-71 34820578-10 2022 Taken together, these findings reveal the release of H2 from magnesium-based biomaterial exerts its anti-tumoral activity by activating the P53-mediated lysosome-mitochondria apoptosis signaling pathway, which strengthens the therapeutic potential of this biomaterial as localized anti-tumor treatment. Magnesium 61-70 transformation related protein 53, pseudogene Mus musculus 140-143 34297565-5 2021 The cluster geometries obtained from the global DFT optimization were then used to adjust two empirical potentials of Gupta type (GP) and modified Sutton-Chen type (SCG3) describing the interactions between the magnesium atoms. Magnesium 211-220 secretogranin III Homo sapiens 165-169 34186235-0 2021 Biodegradable magnesium combined with distraction osteogenesis synergistically stimulates bone tissue regeneration via CGRP-FAK-VEGF signaling axis. Magnesium 14-23 vascular endothelial growth factor A Rattus norvegicus 128-132 34186235-9 2021 Moreover, inhibitor/antagonist of CGRP receptor, FAK, and VEGF receptor blocked the Mg nail stimulated vessel and bone formation. Magnesium 84-86 protein tyrosine kinase 2 Rattus norvegicus 49-52 34186235-10 2021 We revealed, for the first time, a CGRP-FAK-VEGF signaling axis linking sensory nerve and endothelial cells, which may be the main mechanism underlying Mg-enhanced critical size bone defect repair when combined with DO, suggesting a great potential of Mg implants in reducing DO treatment time for clinical applications. Magnesium 152-154 vascular endothelial growth factor A Rattus norvegicus 44-48 34334139-5 2021 These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-alpha and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases. Magnesium 39-48 interleukin 6 Homo sapiens 170-174 34334139-5 2021 These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-alpha and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases. Magnesium 39-48 tumor necrosis factor Homo sapiens 176-185 34334139-5 2021 These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-alpha and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases. Magnesium 39-48 interleukin 17A Homo sapiens 190-195 34334139-5 2021 These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-alpha and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases. Magnesium 39-48 insulin Homo sapiens 298-305 34361439-4 2021 The microstructure of Mg-24%Cu and Mg-31%Cu is composed of alpha-Mg matrix and binary eutectic phases, and Mg-45%Cu is composed of primary Mg2Cu and binary eutectic phases. Magnesium 22-24 amelogenin X-linked Homo sapiens 59-67 34361439-4 2021 The microstructure of Mg-24%Cu and Mg-31%Cu is composed of alpha-Mg matrix and binary eutectic phases, and Mg-45%Cu is composed of primary Mg2Cu and binary eutectic phases. Magnesium 35-37 amelogenin X-linked Homo sapiens 59-67 34321462-6 2021 We find that ARH3-dependent hydrolysis requires both rearrangement of a catalytic glutamate and induction of an unusual, square-pyramidal magnesium coordination geometry. Magnesium 138-147 ADP-ribosylserine hydrolase Homo sapiens 13-17 34298788-8 2021 Patients with MGMT-methylated tumors had significantly higher cerebral magnesium (Mg) values and PME/PDE ratio, while their PCr/ATP and PCr/Pi ratios were lower than in patients without the methylation. Magnesium 71-80 O-6-methylguanine-DNA methyltransferase Homo sapiens 14-18 34298788-8 2021 Patients with MGMT-methylated tumors had significantly higher cerebral magnesium (Mg) values and PME/PDE ratio, while their PCr/ATP and PCr/Pi ratios were lower than in patients without the methylation. Magnesium 82-84 O-6-methylguanine-DNA methyltransferase Homo sapiens 14-18 34316513-5 2021 We found that LINC00707 levels are significantly higher in the osteosarcoma cell lines SW 1353, HOS, U-2 OS, MG-63, and Saos-2 compared to those in human fetal osteoblastic cell line hFOB1.19. Magnesium 109-111 long intergenic non-protein coding RNA 707 Homo sapiens 14-23 34316513-6 2021 LINC00707 silencing suppressed cell proliferation, migration, and invasion of MG-63 and Saos-2 cells. Magnesium 78-80 long intergenic non-protein coding RNA 707 Homo sapiens 0-9 34716795-4 2021 In particular, when the doping concentration reaches to 14.29%, the adsorption energies of Mg on Mo2C0.875N0.125 are in the region between -1.639 and -1.517 eV, e.g., the adsorption energies of Mg on TC1 and H2 sites are -1.639 eV and -1.625 eV, which are decreased by 16.49% and 18.43% as compared with the pristine Mo2C. Magnesium 194-196 transcriptional and immune response regulator Homo sapiens 200-203 34417961-10 2021 Three SNPs in ALPK1, ASAP1-ADCY8 and IER3IP1-SKOR2 also achieved a significant association with Mg element levels (p < 5 x 10-6). Magnesium 96-98 alpha kinase 1 Homo sapiens 14-19 34417961-10 2021 Three SNPs in ALPK1, ASAP1-ADCY8 and IER3IP1-SKOR2 also achieved a significant association with Mg element levels (p < 5 x 10-6). Magnesium 96-98 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Homo sapiens 21-26 34417961-10 2021 Three SNPs in ALPK1, ASAP1-ADCY8 and IER3IP1-SKOR2 also achieved a significant association with Mg element levels (p < 5 x 10-6). Magnesium 96-98 adenylate cyclase 8 Homo sapiens 27-32 34417961-10 2021 Three SNPs in ALPK1, ASAP1-ADCY8 and IER3IP1-SKOR2 also achieved a significant association with Mg element levels (p < 5 x 10-6). Magnesium 96-98 immediate early response 3 interacting protein 1 Homo sapiens 37-44 34417961-10 2021 Three SNPs in ALPK1, ASAP1-ADCY8 and IER3IP1-SKOR2 also achieved a significant association with Mg element levels (p < 5 x 10-6). Magnesium 96-98 SKI family transcriptional corepressor 2 Homo sapiens 45-50 34445449-0 2021 Modulation of the Cardiac Myocyte Action Potential by the Magnesium-Sensitive TRPM6 and TRPM7-like Current. Magnesium 58-67 transient receptor potential cation channel subfamily M member 6 Sus scrofa 78-83 34445449-0 2021 Modulation of the Cardiac Myocyte Action Potential by the Magnesium-Sensitive TRPM6 and TRPM7-like Current. Magnesium 58-67 transient receptor potential cation channel subfamily M member 7 Sus scrofa 88-93 34313418-6 2021 The Mg doping concentration and distribution profile of the p++-GaN shell were inspected using three-dimensional atom probe tomography. Magnesium 4-6 gigaxonin Homo sapiens 64-67 34313418-9 2021 Excluding the Mg atoms contained in the clusters, the remaining Mg doping concentration in the p++-GaN region was calculated to be 1.1 x 1020 cm-3. Magnesium 64-66 gigaxonin Homo sapiens 99-102 34328308-3 2021 Herein, we report the properties of a new additive, bismuth triflate (Bi(OTf)3), for synthesizing a chlorine-free Mg electrolyte to enhance Mg plating/stripping from initial cycles. Magnesium 114-116 POU class 5 homeobox 1 Homo sapiens 69-78 34328308-3 2021 Herein, we report the properties of a new additive, bismuth triflate (Bi(OTf)3), for synthesizing a chlorine-free Mg electrolyte to enhance Mg plating/stripping from initial cycles. Magnesium 140-142 POU class 5 homeobox 1 Homo sapiens 69-78 34444908-6 2021 Inositols and vitamin D supplementation, as well as micronutrients (zinc, chromium, magnesium) and pre/probiotics, result in modest improvement in insulin sensitivity, but their use is not systematically suggested. Magnesium 84-93 insulin Homo sapiens 147-154 34443385-0 2021 Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy. Magnesium 0-9 MHC class I polypeptide-related sequence A Homo sapiens 63-67 34348722-12 2021 OGTT showed that her glucose metabolism and insulin resistance much improved after potassium and magnesium supplemental therapy. Magnesium 97-106 insulin Homo sapiens 44-51 34089433-4 2021 Altogether, seven minerals-Cu, Fe, K, Mg, Mn, Na, and P-were above the detection limit with the analysis revealing increased iron content in the heart of Fmr1 KO mice. Magnesium 38-40 fragile X messenger ribonucleoprotein 1 Mus musculus 154-158 34704948-14 2021 The cTnI levels were lower in those patients whose serum Mg levels were higher than 1.94. Magnesium 57-59 troponin I3, cardiac type Homo sapiens 4-8 34292519-12 2021 Our results suggest that the increased intracellular magnesium concentration was related to L-lactate-induced cytosolic acidosis and to the activation of the NHE1/NCX1 axis. Magnesium 53-62 solute carrier family 9 member A1 Rattus norvegicus 158-162 34292519-12 2021 Our results suggest that the increased intracellular magnesium concentration was related to L-lactate-induced cytosolic acidosis and to the activation of the NHE1/NCX1 axis. Magnesium 53-62 solute carrier family 8 member A1 Rattus norvegicus 163-167 34212172-5 2021 In this work, layered calcite was synthesized on the surface of chitosan (CS) films at room temperature under the coordinated control of magnesium ions (Mg2+) and polyacrylic acid (PAA). Magnesium 137-146 citrate synthase Homo sapiens 74-76 34116393-9 2021 These findings, if confirmed, provide another mechanism for the role of Mg intervention in the prevention of COVID-19 and treatment of early and mild disease by modifying the phenotype of the TMPRSS2 genotype. Magnesium 72-74 transmembrane serine protease 2 Homo sapiens 192-199 34300817-5 2021 The experimental results showed that magnesium residue"s properties, the BET surface gradually decreased and the crystal size increased with increasing calcination temperature, resulting in a longer setting time of MOC cement. Magnesium 37-46 delta/notch like EGF repeat containing Homo sapiens 73-76 34295261-2 2021 FOS-like 2, AP-1 transcription factor subunit (FOSL2) was identified as a candidate gene related to muscle glycogen (MG) content in chicken in our previous study, but the role of FOSL2 in the regulation of MG content remains to be elucidated. Magnesium 117-119 FOS like 2, AP-1 transcription factor subunit Gallus gallus 47-52 34295261-2 2021 FOS-like 2, AP-1 transcription factor subunit (FOSL2) was identified as a candidate gene related to muscle glycogen (MG) content in chicken in our previous study, but the role of FOSL2 in the regulation of MG content remains to be elucidated. Magnesium 206-208 FOS like 2, AP-1 transcription factor subunit Gallus gallus 179-184 34295261-4 2021 Analysis of the 1,171 DEGs (LMG vs. HMG) identified, besides FOSL2, some additional genes related to MG metabolism pathway, namely PRKAG3, CEBPB, FOXO1, AMPK, and PIK3CB. Magnesium 101-103 protein kinase AMP-activated non-catalytic subunit gamma 3 Gallus gallus 131-137 34295261-5 2021 Additionally, WGCNA revealed that FOSL2, CEBPB, MAP3K14, SLC2A14, PPP2CA, SLC38A2, PPP2R5E, and other genes related to the classical glycogen metabolism in the same coexpressed module are associated with MG content. Magnesium 204-206 FOS like 2, AP-1 transcription factor subunit Gallus gallus 34-39 34295261-5 2021 Additionally, WGCNA revealed that FOSL2, CEBPB, MAP3K14, SLC2A14, PPP2CA, SLC38A2, PPP2R5E, and other genes related to the classical glycogen metabolism in the same coexpressed module are associated with MG content. Magnesium 204-206 CCAAT/enhancer binding protein beta Gallus gallus 41-46 34295261-5 2021 Additionally, WGCNA revealed that FOSL2, CEBPB, MAP3K14, SLC2A14, PPP2CA, SLC38A2, PPP2R5E, and other genes related to the classical glycogen metabolism in the same coexpressed module are associated with MG content. Magnesium 204-206 mitogen-activated protein kinase kinase kinase 14 Gallus gallus 48-55 34295261-5 2021 Additionally, WGCNA revealed that FOSL2, CEBPB, MAP3K14, SLC2A14, PPP2CA, SLC38A2, PPP2R5E, and other genes related to the classical glycogen metabolism in the same coexpressed module are associated with MG content. Magnesium 204-206 protein phosphatase 2 catalytic subunit alpha Gallus gallus 66-72 34295261-5 2021 Additionally, WGCNA revealed that FOSL2, CEBPB, MAP3K14, SLC2A14, PPP2CA, SLC38A2, PPP2R5E, and other genes related to the classical glycogen metabolism in the same coexpressed module are associated with MG content. Magnesium 204-206 solute carrier family 38 member 2 Gallus gallus 74-81 34295261-5 2021 Additionally, WGCNA revealed that FOSL2, CEBPB, MAP3K14, SLC2A14, PPP2CA, SLC38A2, PPP2R5E, and other genes related to the classical glycogen metabolism in the same coexpressed module are associated with MG content. Magnesium 204-206 protein phosphatase 2 regulatory subunit B'epsilon Gallus gallus 83-90 34295261-8 2021 Collectively, our results confirm that FOSL2 has a key role in the regulation of the MG content in chicken. Magnesium 85-87 FOS like 2, AP-1 transcription factor subunit Gallus gallus 39-44 34180110-6 2021 He-CTD predominantly generated 1+ fragments from 1+ precursors and 2+ product ions from 2+ precursors, although both LE-CID and He-CTD were able to generate 1+ product ions from 2+ adducts of magnesium and calcium. Magnesium 192-201 CTD Homo sapiens 131-134 34541389-0 2022 Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/beta-catenin signaling. Magnesium 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 71-75 34541389-0 2022 Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/beta-catenin signaling. Magnesium 0-9 activating transcription factor 4 Mus musculus 99-103 34541389-0 2022 Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/beta-catenin signaling. Magnesium 0-9 catenin (cadherin associated protein), beta 1 Mus musculus 118-130 34541389-3 2022 Here we report that implantation of magnesium-containing implant stimulates bone formation and improves bone fracture healing in CFTR-mutant mice. Magnesium 36-45 cystic fibrosis transmembrane conductance regulator Mus musculus 129-133 34541389-4 2022 Wnt/beta-catenin signaling in the bone is enhanced by the magnesium implant, and inhibition of Wnt/beta-catenin by iCRT14 blocks the magnesium implant to improve fracture healing in CFTR-mutant mice. Magnesium 58-67 catenin (cadherin associated protein), beta 1 Mus musculus 4-16 34541389-4 2022 Wnt/beta-catenin signaling in the bone is enhanced by the magnesium implant, and inhibition of Wnt/beta-catenin by iCRT14 blocks the magnesium implant to improve fracture healing in CFTR-mutant mice. Magnesium 133-142 catenin (cadherin associated protein), beta 1 Mus musculus 99-111 34541389-5 2022 We further demonstrate that magnesium ion enters osteocytes, increases intracellular cAMP level and activates ATF4, a key transcription factor known to regulate Wnt/beta-catenin signaling. Magnesium 28-37 activating transcription factor 4 Mus musculus 110-114 34541389-5 2022 We further demonstrate that magnesium ion enters osteocytes, increases intracellular cAMP level and activates ATF4, a key transcription factor known to regulate Wnt/beta-catenin signaling. Magnesium 28-37 catenin (cadherin associated protein), beta 1 Mus musculus 165-177 34541389-6 2022 In vivo knockdown of ATF4 abolishes the magnesium implant-activated beta-catenin in bones and reverses the improved-fracture healing in CFTR-mutant mice. Magnesium 40-49 activating transcription factor 4 Mus musculus 21-25 34541389-6 2022 In vivo knockdown of ATF4 abolishes the magnesium implant-activated beta-catenin in bones and reverses the improved-fracture healing in CFTR-mutant mice. Magnesium 40-49 catenin (cadherin associated protein), beta 1 Mus musculus 68-80 34541389-7 2022 In addition, oral supplementation of magnesium activates ATF4 and beta-catenin as well as enhances bone volume and density in CFTR-mutant mice. Magnesium 37-46 activating transcription factor 4 Mus musculus 57-61 34541389-7 2022 In addition, oral supplementation of magnesium activates ATF4 and beta-catenin as well as enhances bone volume and density in CFTR-mutant mice. Magnesium 37-46 catenin (cadherin associated protein), beta 1 Mus musculus 66-78 34541389-7 2022 In addition, oral supplementation of magnesium activates ATF4 and beta-catenin as well as enhances bone volume and density in CFTR-mutant mice. Magnesium 37-46 cystic fibrosis transmembrane conductance regulator Mus musculus 126-130 34541389-9 2022 Activation of ATF4-dependent Wnt/beta-catenin signaling in osteocytes is identified as a previously undefined mechanism underlying the beneficial effect of magnesium on bone formation. Magnesium 156-165 activating transcription factor 4 Mus musculus 14-18 34541389-9 2022 Activation of ATF4-dependent Wnt/beta-catenin signaling in osteocytes is identified as a previously undefined mechanism underlying the beneficial effect of magnesium on bone formation. Magnesium 156-165 catenin (cadherin associated protein), beta 1 Mus musculus 33-45 34210242-1 2021 OBJECTIVES: This study aimed to evaluate the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms. Magnesium 73-82 brain derived neurotrophic factor Homo sapiens 124-128 34210242-1 2021 OBJECTIVES: This study aimed to evaluate the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms. Magnesium 73-82 sirtuin 1 Homo sapiens 148-153 34210242-8 2021 CONCLUSION: Vitamin D plus magnesium supplementation in obese women with mild to moderate depressive symptoms has beneficial influences on mood, serum levels of BDNF, inflammation, and SIRT1. Magnesium 27-36 brain derived neurotrophic factor Homo sapiens 161-165 34210242-8 2021 CONCLUSION: Vitamin D plus magnesium supplementation in obese women with mild to moderate depressive symptoms has beneficial influences on mood, serum levels of BDNF, inflammation, and SIRT1. Magnesium 27-36 sirtuin 1 Homo sapiens 185-190 34089346-0 2021 ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs. Magnesium 16-25 ADP ribosylation factor like GTPase 15 Homo sapiens 0-5 34089346-1 2021 Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Magnesium 55-64 cyclin L2 Homo sapiens 0-8 34089346-1 2021 Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Magnesium 55-64 cyclin and CBS domain divalent metal cation transport mediator 1 Homo sapiens 10-17 34142812-4 2021 Herein, we employ electrochemical experiments using Ag2S quasi-reference electrodes to probe the interactions between Mg anodes and dissolved polysulfides. Magnesium 118-120 angiotensin II receptor type 1 Homo sapiens 52-56 34203374-3 2021 In this study, an Mg-Al-B alloy was synthesized from magnesium, aluminum and boron powders in a 1:1:4 molar ratio by preheating to 600 C for 30 min, followed by high-temperature sintering in a tube furnace. Magnesium 53-62 albumin Homo sapiens 21-25 34248844-0 2021 Associations of Serum Magnesium With Insulin Resistance and Testosterone in Women With Polycystic Ovary Syndrome. Magnesium 22-31 insulin Homo sapiens 37-44 34201589-0 2021 Therapeutic Effects of the Addition of Fibroblast Growth Factor-2 to Biodegradable Gelatin/Magnesium-Doped Calcium Silicate Hybrid 3D-Printed Scaffold with Enhanced Osteogenic Capabilities for Critical Bone Defect Restoration. Magnesium 91-100 fibroblast growth factor 2 Homo sapiens 39-65 34086951-7 2021 Phosphorus deficiency led to decreasing intracellular concentrations not only of P, but also of K, Cu, and to increasing Zn concentration after 48 h. Mg maintained its concentration at approximate 0.11 fg mum-3 and did not change significantly under the three investigated conditions after 48 h. Accordingly, Mg content was successfully used to estimate the intracellular concentration of other intrinsic elements in single yeast cells. Magnesium 150-152 Mum3p Saccharomyces cerevisiae S288C 205-210 34143369-1 2022 This is a comprehensive systematic review and dose-response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) among adults. Magnesium 105-114 C-reactive protein Homo sapiens 168-186 34143369-1 2022 This is a comprehensive systematic review and dose-response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) among adults. Magnesium 105-114 C-reactive protein Homo sapiens 188-191 34143369-1 2022 This is a comprehensive systematic review and dose-response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) among adults. Magnesium 105-114 interleukin 6 Homo sapiens 194-207 34143369-1 2022 This is a comprehensive systematic review and dose-response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) among adults. Magnesium 105-114 interleukin 6 Homo sapiens 209-213 34143369-1 2022 This is a comprehensive systematic review and dose-response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) among adults. Magnesium 105-114 tumor necrosis factor Homo sapiens 220-247 34143369-1 2022 This is a comprehensive systematic review and dose-response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) among adults. Magnesium 105-114 tumor necrosis factor Homo sapiens 249-258 34081070-10 2021 Furthermore, selectivity of the hybrid was confirmed by selective sorption of the above heavy metal ions from mixtures involving alkali (Na(i), K(i)) and alkaline Earth (Mg(ii), Ca(ii)) metal ions due to the chelating properties of the terpyridine subunits, as demonstrated with municipal drinking (tap) water samples. Magnesium 170-172 carbonic anhydrase 2 Homo sapiens 173-175 34127173-8 2021 However, to substantiate the PRIMA model even further, more research is needed to further validate the model for a broad range of MG. Magnesium 130-132 proline rich membrane anchor 1 Homo sapiens 29-34 34110053-5 2021 Statistical analysis indicated that the NH3 -N concentration (mg) was significantly correlated with the CNCPS N-fractions (g) PB1 , PB2 and PB3 in a multiple linear pattern: NH3 -N = (130.70+-33.80) PB1 + (155.83+-17.89) PB2 - (85.44+-37.69) PB3 + (42.43+-1.05), R2 = 0.77, p < 0.0001, n = 45. Magnesium 62-64 polybromo 1 Bos taurus 126-129 34110053-5 2021 Statistical analysis indicated that the NH3 -N concentration (mg) was significantly correlated with the CNCPS N-fractions (g) PB1 , PB2 and PB3 in a multiple linear pattern: NH3 -N = (130.70+-33.80) PB1 + (155.83+-17.89) PB2 - (85.44+-37.69) PB3 + (42.43+-1.05), R2 = 0.77, p < 0.0001, n = 45. Magnesium 62-64 polybromo 1 Bos taurus 199-202 34200272-6 2021 Elastic anomalies and energy loss in (NH4)(Mg(HCOO)3) near 256 K are due to the second-order paraelectric to ferroelectric phase transition triggered by the disorder-order transition of the ammonium cations and their displacement within the framework channels, accompanied by the structural phase transition from the non-polar hexagonal P6322 to polar hexagonal P63. Magnesium 43-45 tumor protein p63 Homo sapiens 362-365 34092248-11 2021 Moreover, combined melatonin and magnesium supplementation was more effective in improving serum levels of cholesterol, LDL-C, HDL-C and insulin, and HOMA-IR. Magnesium 33-42 insulin Homo sapiens 137-144 34204873-14 2021 Whilst for MG-63, the significantly down-regulated oncogenes were Serpin E1, AKT2, VEGF, uPA, PD-ECGF, and Endoglin. Magnesium 11-13 serpin family E member 1 Homo sapiens 66-75 34204873-14 2021 Whilst for MG-63, the significantly down-regulated oncogenes were Serpin E1, AKT2, VEGF, uPA, PD-ECGF, and Endoglin. Magnesium 11-13 AKT serine/threonine kinase 2 Homo sapiens 77-81 34204873-14 2021 Whilst for MG-63, the significantly down-regulated oncogenes were Serpin E1, AKT2, VEGF, uPA, PD-ECGF, and Endoglin. Magnesium 11-13 vascular endothelial growth factor A Homo sapiens 83-87 34204873-14 2021 Whilst for MG-63, the significantly down-regulated oncogenes were Serpin E1, AKT2, VEGF, uPA, PD-ECGF, and Endoglin. Magnesium 11-13 proline rich acidic protein 1 Homo sapiens 89-92 34204873-14 2021 Whilst for MG-63, the significantly down-regulated oncogenes were Serpin E1, AKT2, VEGF, uPA, PD-ECGF, and Endoglin. Magnesium 11-13 thymidine phosphorylase Homo sapiens 94-101 34204873-14 2021 Whilst for MG-63, the significantly down-regulated oncogenes were Serpin E1, AKT2, VEGF, uPA, PD-ECGF, and Endoglin. Magnesium 11-13 endoglin Homo sapiens 107-115 34076594-0 2021 Structure of human factor VIIa-soluble tissue factor with calcium, magnesium and rubidium. Magnesium 67-76 coagulation factor III, tissue factor Homo sapiens 39-52 34072724-0 2021 The Combined Influence of Magnesium and Insulin on Central Metabolic Functions and Expression of Genes Involved in Magnesium Homeostasis of Cultured Bovine Adipocytes. Magnesium 115-124 insulin Bos taurus 40-47 34072724-5 2021 Expression of SLC41A1 and SLC41A3 was reduced at 0.1 mM magnesium either across insulin concentrations (SLC41A1) or at 250 pM insulin (SLC41A3). Magnesium 56-65 solute carrier family 41 member 1 Bos taurus 14-21 34072724-5 2021 Expression of SLC41A1 and SLC41A3 was reduced at 0.1 mM magnesium either across insulin concentrations (SLC41A1) or at 250 pM insulin (SLC41A3). Magnesium 56-65 solute carrier family 41 member 3 Bos taurus 26-33 34072724-5 2021 Expression of SLC41A1 and SLC41A3 was reduced at 0.1 mM magnesium either across insulin concentrations (SLC41A1) or at 250 pM insulin (SLC41A3). Magnesium 56-65 insulin Bos taurus 80-87 34072724-5 2021 Expression of SLC41A1 and SLC41A3 was reduced at 0.1 mM magnesium either across insulin concentrations (SLC41A1) or at 250 pM insulin (SLC41A3). Magnesium 56-65 solute carrier family 41 member 1 Bos taurus 104-111 34072724-5 2021 Expression of SLC41A1 and SLC41A3 was reduced at 0.1 mM magnesium either across insulin concentrations (SLC41A1) or at 250 pM insulin (SLC41A3). Magnesium 56-65 solute carrier family 41 member 3 Bos taurus 135-142 34072724-6 2021 MAGT1 expression was reduced at 3 mM magnesium. Magnesium 37-46 magnesium transporter 1 Bos taurus 0-5 34072724-7 2021 NIPA1 expression was reduced at 3 mM and 0.1 mM magnesium at 25 and 250 pM insulin, respectively. Magnesium 48-57 NIPA magnesium transporter 1 Bos taurus 0-5 34072724-7 2021 NIPA1 expression was reduced at 3 mM and 0.1 mM magnesium at 25 and 250 pM insulin, respectively. Magnesium 48-57 insulin Bos taurus 75-82 34072724-10 2021 The induction of GAPDH activity by surplus magnesium at low insulin concentration can counteract excessive lipomobilization. Magnesium 43-52 insulin Bos taurus 60-67 34211729-7 2021 Co-cultured with Mg alloy extract, ECs showed contractive adhesion morphology and decreased motility, which was supported by the down-regulation of adhesion-related genes (Paxillin and Vinculin) and migration-related genes (RAC 1, Rho A and CDC 42). Magnesium 17-19 paxillin Homo sapiens 172-180 34211729-7 2021 Co-cultured with Mg alloy extract, ECs showed contractive adhesion morphology and decreased motility, which was supported by the down-regulation of adhesion-related genes (Paxillin and Vinculin) and migration-related genes (RAC 1, Rho A and CDC 42). Magnesium 17-19 vinculin Homo sapiens 185-193 34211729-7 2021 Co-cultured with Mg alloy extract, ECs showed contractive adhesion morphology and decreased motility, which was supported by the down-regulation of adhesion-related genes (Paxillin and Vinculin) and migration-related genes (RAC 1, Rho A and CDC 42). Magnesium 17-19 Rac family small GTPase 1 Homo sapiens 224-229 34211729-7 2021 Co-cultured with Mg alloy extract, ECs showed contractive adhesion morphology and decreased motility, which was supported by the down-regulation of adhesion-related genes (Paxillin and Vinculin) and migration-related genes (RAC 1, Rho A and CDC 42). Magnesium 17-19 ras homolog family member A Homo sapiens 231-236 34211729-7 2021 Co-cultured with Mg alloy extract, ECs showed contractive adhesion morphology and decreased motility, which was supported by the down-regulation of adhesion-related genes (Paxillin and Vinculin) and migration-related genes (RAC 1, Rho A and CDC 42). Magnesium 17-19 cell division cycle 42 Homo sapiens 241-247 34067290-5 2021 Moreover, the content of intracellular magnesium, known to contribute to protect cells from oxidative stress, is increased in DXR-resistant LoVo through the upregulation of MagT1 and in DXR-resistant HL60 because of the overexpression of TRPM7. Magnesium 39-48 magnesium transporter 1 Homo sapiens 173-178 34067290-5 2021 Moreover, the content of intracellular magnesium, known to contribute to protect cells from oxidative stress, is increased in DXR-resistant LoVo through the upregulation of MagT1 and in DXR-resistant HL60 because of the overexpression of TRPM7. Magnesium 39-48 transient receptor potential cation channel subfamily M member 7 Homo sapiens 238-243 34065270-6 2021 In these results, DOW with high magnesium levels reduced serum and liver triglyceride and cholesterol levels and serum AST and ALT activities. Magnesium 32-41 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 119-122 34065270-6 2021 In these results, DOW with high magnesium levels reduced serum and liver triglyceride and cholesterol levels and serum AST and ALT activities. Magnesium 32-41 glutamic pyruvic transaminase, soluble Mus musculus 127-130 34248844-1 2021 Objective: This article aimed to investigate whether serum magnesium is associated with insulin resistance index and testosterone level in women with polycystic ovary syndrome (PCOS). Magnesium 59-68 insulin Homo sapiens 88-95 34248844-7 2021 Multiple linear regression showed serum magnesium was independently negatively associated with insulin, glucose, HOMA-IR, testosterone and positively associated with QUICKI (P for trend <0.05) after adjusting confounding covariates. Magnesium 40-49 insulin Homo sapiens 95-102 34248844-9 2021 Conclusion: The current findings suggest that lower serum magnesium was associated with aggravated insulin resistance and higher testosterone levels among women with PCOS. Magnesium 58-67 insulin Homo sapiens 99-106 34927892-0 2021 Micro-/Nano-Structures on Biodegradable Magnesium@PLGA and Their Cytotoxicity, Photothermal, and Anti-Tumor Effects. Magnesium 40-49 nanomouse Mus musculus 7-11 34368799-4 2021 Methods: We performed a cohort study comparing urinary albumin (mug):creatinine (mg) ratio (ACR) in CD patients vs controls and in response to a GFD. Magnesium 81-83 albumin Homo sapiens 55-62 34368799-4 2021 Methods: We performed a cohort study comparing urinary albumin (mug):creatinine (mg) ratio (ACR) in CD patients vs controls and in response to a GFD. Magnesium 81-83 acrosin Homo sapiens 92-95 34277971-2 2021 In clinical trials, participants with T2D randomized to sodium-glucose co-transporter 2 (SGLT2) inhibitors have shown mild to moderate increases in serum Mg from baseline levels. Magnesium 154-156 solute carrier family 5 member 2 Homo sapiens 56-87 34277971-2 2021 In clinical trials, participants with T2D randomized to sodium-glucose co-transporter 2 (SGLT2) inhibitors have shown mild to moderate increases in serum Mg from baseline levels. Magnesium 154-156 solute carrier family 5 member 2 Homo sapiens 89-94 34515155-2 2021 Specifically, magnesium (Mg2+) channel transient receptor potential melastatin (TRPM) 6 and TRPM7 are essential for brain function and development. Magnesium 14-23 transient receptor potential cation channel subfamily M member 7 Homo sapiens 92-97 34515155-6 2021 The CNNM2 gene is crucial for renal magnesium handling, brain development, and neurological functioning. Magnesium 36-45 cyclin and CBS domain divalent metal cation transport mediator 2 Homo sapiens 4-9 34553578-6 2021 RESULTS: A significant increase in the concentrations of VEGF and trace elements Mg, Mn, Cu, Zn, and Se in the blood serum of patients with ischemic stroke was revealed. Magnesium 81-83 vascular endothelial growth factor A Homo sapiens 57-61 35245757-4 2022 Diacetyl (DA) content was not high enough to form corresponding pyrazines in the MG-ARP model. Magnesium 81-83 mesencephalic astrocyte derived neurotrophic factor Homo sapiens 84-87 34134118-0 2021 The Association of Urinary Sclerostin and Renal Magnesium Handling in Type 2 Diabetic Patients with Chronic Kidney Disease. Magnesium 48-57 sclerostin Homo sapiens 27-37 34134118-2 2021 The association between sclerostin and magnesium (Mg) has not yet discovered. Magnesium 50-52 sclerostin Homo sapiens 24-34 34134118-4 2021 Therefore, we tried to evaluate if there was any association between sclerostin and fractional excretion of Ca, P, and Mg (FeCa, FeP, and FeMg) in T2DM with CKD. Magnesium 119-121 sclerostin Homo sapiens 69-79 35245757-5 2022 The insufficient interaction of precursors and rapid drops in pH limited the formation of pyrazines during MG-ARP degradation. Magnesium 107-109 mesencephalic astrocyte derived neurotrophic factor Homo sapiens 110-113 35106922-0 2022 Magnesium promotes osteogenesis via increasing OPN expression and activating CaM/CaMKIV/CREB1 pathway. Magnesium 0-9 secreted phosphoprotein 1 Homo sapiens 47-50 35106922-10 2022 These data indicated that the osteogenic effect of Mg is related to the activation OPN through CaM/CaMKIV/CREB1 signaling pathway. Magnesium 51-53 secreted phosphoprotein 1 Homo sapiens 83-86 35106922-0 2022 Magnesium promotes osteogenesis via increasing OPN expression and activating CaM/CaMKIV/CREB1 pathway. Magnesium 0-9 calmodulin 1 Homo sapiens 77-80 35106922-10 2022 These data indicated that the osteogenic effect of Mg is related to the activation OPN through CaM/CaMKIV/CREB1 signaling pathway. Magnesium 51-53 calmodulin 1 Homo sapiens 95-98 35106922-0 2022 Magnesium promotes osteogenesis via increasing OPN expression and activating CaM/CaMKIV/CREB1 pathway. Magnesium 0-9 calcium/calmodulin dependent protein kinase IV Homo sapiens 81-87 35106922-10 2022 These data indicated that the osteogenic effect of Mg is related to the activation OPN through CaM/CaMKIV/CREB1 signaling pathway. Magnesium 51-53 calcium/calmodulin dependent protein kinase IV Homo sapiens 99-105 35106922-10 2022 These data indicated that the osteogenic effect of Mg is related to the activation OPN through CaM/CaMKIV/CREB1 signaling pathway. Magnesium 51-53 cAMP responsive element binding protein 1 Homo sapiens 106-111 35106922-0 2022 Magnesium promotes osteogenesis via increasing OPN expression and activating CaM/CaMKIV/CREB1 pathway. Magnesium 0-9 cAMP responsive element binding protein 1 Homo sapiens 88-93 35106922-3 2022 Results showed that magnesium exerts a dose-dependent increase in the proliferation of MC3T3 and MG63 cells, and in the expression of osteopontin (OPN), a promising biomarker of osteogenesis. Magnesium 20-29 secreted phosphoprotein 1 Homo sapiens 134-145 35106922-3 2022 Results showed that magnesium exerts a dose-dependent increase in the proliferation of MC3T3 and MG63 cells, and in the expression of osteopontin (OPN), a promising biomarker of osteogenesis. Magnesium 20-29 secreted phosphoprotein 1 Homo sapiens 147-150 35615903-7 2022 Moreover, both MORF2 and MORF9 significantly stimulate magnesium chelatase activity. Magnesium 55-64 plastid developmental protein DAG Arabidopsis thaliana 25-30 35631690-0 2022 Impact of Magnesium on Oxytocin Receptor Function. Magnesium 10-19 oxytocin receptor Rattus norvegicus 23-40 35606529-1 2022 BACKGROUND: Resorption of magnesium-based alloy bioabsorbable screws produces hydrogen gas, which can be mistaken as a sign of infection and may affect the physis or fixed bone fragment. Magnesium 26-35 gastrin Homo sapiens 87-90 35606529-2 2022 OBJECTIVE: We evaluated the temporal and spatial occurrence of gas and the occurrence of a breakage of the fixed bone fragment or screw following magnesium screw fixation. Magnesium 146-155 gastrin Homo sapiens 63-66 35631690-2 2022 Magnesium ion (Mg2+) concentration is critical to the activation of the OTR, and a low serum Mg2+ concentration is predictive of a migraine headache. Magnesium 0-9 oxytocin receptor Rattus norvegicus 72-75 35587044-4 2022 It has been reported that the magnesium ion (Mg2+ ) can competitively block the NMDAR and reduce the calcium influx, and that sonic hedgehog (Shh) and retinoic acid (RA) are the critical regulators of neuronal differentiation of endogenous neural stem cells (NSCs). Magnesium 30-39 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 80-85 35587044-4 2022 It has been reported that the magnesium ion (Mg2+ ) can competitively block the NMDAR and reduce the calcium influx, and that sonic hedgehog (Shh) and retinoic acid (RA) are the critical regulators of neuronal differentiation of endogenous neural stem cells (NSCs). Magnesium 30-39 sonic hedgehog Mus musculus 126-140 35587044-4 2022 It has been reported that the magnesium ion (Mg2+ ) can competitively block the NMDAR and reduce the calcium influx, and that sonic hedgehog (Shh) and retinoic acid (RA) are the critical regulators of neuronal differentiation of endogenous neural stem cells (NSCs). Magnesium 30-39 sonic hedgehog Mus musculus 142-145 35590402-10 2022 There were significant variations in postoperative sodium, magnesium, chloride and carbon dioxide capacity in hip arthroscopy (p < 0.05). Magnesium 59-68 hedgehog interacting protein Homo sapiens 110-113 35503734-4 2022 To tackle these challenges, we herein developed a fluorescent probe PSPA for in situ 3D monitoring of the dynamic corrosion processes of Mg alloys on the basis of its selective turn-on detection ability toward magnesium hydroxide (Mg(OH)2), which is the main corrosion product of Mg alloys in biophysiological media. Magnesium 137-139 surfactant protein A2 Homo sapiens 68-72 35503734-4 2022 To tackle these challenges, we herein developed a fluorescent probe PSPA for in situ 3D monitoring of the dynamic corrosion processes of Mg alloys on the basis of its selective turn-on detection ability toward magnesium hydroxide (Mg(OH)2), which is the main corrosion product of Mg alloys in biophysiological media. Magnesium 280-282 surfactant protein A2 Homo sapiens 68-72 35631664-8 2022 An in vitro study showed that metal ions released from Mg-Zn-Ca BMG promoted cell proliferation and migration and elevated alkaline phosphatase (ALP) activity and mineralization. Magnesium 55-57 alkaline phosphatase, placental Homo sapiens 123-143 35631664-8 2022 An in vitro study showed that metal ions released from Mg-Zn-Ca BMG promoted cell proliferation and migration and elevated alkaline phosphatase (ALP) activity and mineralization. Magnesium 55-57 alkaline phosphatase, placental Homo sapiens 145-148 35287922-2 2022 Results showed that PA-beta-CD exhibited high adsorption capacities of 1095, 2005.58, 1736.32, and 1930.23 mg/g for methylene blue (MB), basic green 4 (MG), astrazon pink FG (FG), and crystal violet (MV), respectively. Magnesium 152-154 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 23-30 35546213-0 2022 Leptin and its relationship with magnesium biomarkers in women with obesity. Magnesium 33-42 leptin Homo sapiens 0-6 35546213-1 2022 Some studies have demonstrated the participation of leptin in magnesium metabolism. Magnesium 62-71 leptin Homo sapiens 52-58 35546213-2 2022 On the other hand, there is evidence of the role of magnesium in the leptin intracellular signaling pathway. Magnesium 52-61 leptin Homo sapiens 69-75 35546213-3 2022 Therefore, the aim of this study was to investigate the existence of a relationship between serum leptin concentrations and magnesium biomarkers in women with obesity. Magnesium 124-133 leptin Homo sapiens 98-104 35634398-8 2022 Patients at the highest tertile of dietary magnesium intake had lower serum levels of inflammatory biomarkers, including CRP (11.8 +- 2.2 vs. 29.5 +- 2.1 mg/L, p < 0.001) and ESR (15.8 +- 2.4 vs. 34.7 +- 2.4 mm/hr, p < 0.001), than those at the lowest tertile. Magnesium 43-52 C-reactive protein Homo sapiens 121-124 35447612-1 2022 We have discovered spin-state transition (S = 2 to S = 5/2) of Co ions due to Mg substitution in the Ca3Co2O6apparent in the magnetic susceptibility, XPS, and first-principles study. Magnesium 78-80 spindlin 1 Homo sapiens 19-23 35563524-5 2022 Our data suggest that the presence of the BBB is essential for Mg to exert its effects on brain organoids, and that 5 mM of MgPid is more effective than MgSO4 in increasing the levels of GABA receptors and BDNF, and decreasing those of NMDA receptor. Magnesium 63-65 brain derived neurotrophic factor Homo sapiens 206-210 35503562-3 2022 We performed a systematic review and meta-analysis to assess the effectiveness of magnesium for treatment of Afib/RVR in the ED. Magnesium 82-91 nuclear receptor subfamily 1 group D member 2 Homo sapiens 114-117 35503562-11 2022 We observed that magnesium infusion can be an effective rate control treatment for patients who presented to the ED with Afib/RVR. Magnesium 17-26 nuclear receptor subfamily 1 group D member 2 Homo sapiens 126-129 35498910-0 2022 Strength and failure mechanism of single-lap magnesium-basalt fiber metal laminate adhesively bonded joints: Experimental and numerical assessments. Magnesium 45-54 LAP Homo sapiens 41-44 35484632-9 2022 Unadjusted linear regression showed that dietary magnesium intake is significantly associated with a waist to hip ratio (WHR) and total cholesterol (TC) in men, and hip circumference (HC) in women. Magnesium 49-58 hedgehog interacting protein Homo sapiens 110-113 35484632-9 2022 Unadjusted linear regression showed that dietary magnesium intake is significantly associated with a waist to hip ratio (WHR) and total cholesterol (TC) in men, and hip circumference (HC) in women. Magnesium 49-58 hedgehog interacting protein Homo sapiens 165-168 35591523-1 2022 We demonstrate a cross-linked, 3D conductive network structure, porous silicon@carbon nanofiber (P-Si@CNF) anode by magnesium thermal reduction (MR) and the electrospinning methods. Magnesium 116-125 NPHS1 adhesion molecule, nephrin Homo sapiens 102-105 35565766-18 2022 Lower serum magnesium concentration was associated with a higher risk of insulin resistance and diabetes. Magnesium 12-21 insulin Homo sapiens 73-80 35266176-0 2022 XMEN saved by magnesium. Magnesium 14-23 magnesium transporter 1 Homo sapiens 0-4 35565760-0 2022 Nuclear Magnetic Resonance-Measured Ionized Magnesium Is Inversely Associated with Type 2 Diabetes in the Insulin Resistance Atherosclerosis Study. Magnesium 44-53 insulin Homo sapiens 106-113 35565766-0 2022 Association of Serum Magnesium with Insulin Resistance and Type 2 Diabetes among Adults in China. Magnesium 21-30 insulin Homo sapiens 36-43 35565766-1 2022 Magnesium is an essential mineral for the human body and a cofactor or activator for more than 300 enzymatic reactions, including blood glucose control and insulin release. Magnesium 0-9 insulin Homo sapiens 156-163 35565766-4 2022 Evidence shows that magnesium is a predictor of insulin resistance and diabetes. Magnesium 20-29 insulin Homo sapiens 48-55 35565766-6 2022 We study the correlation of serum magnesium levels with insulin resistance and Type 2 diabetes. Magnesium 34-43 insulin Homo sapiens 56-63 35565766-14 2022 After adjusting for relevant covariates, the third quintile of serum magnesium (0.89-0.93 mmol/L) was correlated with 29% lower risk of incident insulin resistance (hazard ratio = 0.71, 95% CI 0.58, 0.86) and with a lower risk of Type 2 diabetes. Magnesium 69-78 insulin Homo sapiens 145-152 35440685-6 2022 Hierarchical multiple regression of serum magnesium with insulin resistance was adjusted for diabetes and potential magnesium confounders. Magnesium 42-51 insulin Homo sapiens 57-64 35440685-10 2022 The association of low serum magnesium levels with glycaemic control (HbA1c) and high-sensitivity C-reactive protein in individuals with type 1 diabetes is limited to subjects using a high insulin dose and suggests that insulin resistance, a type 2 diabetes feature, is a prerequisite for hypomagnesemia. Magnesium 29-38 C-reactive protein Homo sapiens 98-116 35440685-10 2022 The association of low serum magnesium levels with glycaemic control (HbA1c) and high-sensitivity C-reactive protein in individuals with type 1 diabetes is limited to subjects using a high insulin dose and suggests that insulin resistance, a type 2 diabetes feature, is a prerequisite for hypomagnesemia. Magnesium 29-38 insulin Homo sapiens 189-196 35440685-10 2022 The association of low serum magnesium levels with glycaemic control (HbA1c) and high-sensitivity C-reactive protein in individuals with type 1 diabetes is limited to subjects using a high insulin dose and suggests that insulin resistance, a type 2 diabetes feature, is a prerequisite for hypomagnesemia. Magnesium 29-38 insulin Homo sapiens 220-227 35458077-0 2022 Interaction of Mg Alloy with PLA Electrospun Nanofibers Coating in Understanding Changes of Corrosion, Wettability, and pH. Magnesium 15-17 phenylalanine hydroxylase Homo sapiens 120-122 35458077-7 2022 Taking into account corrosion rate, wettability, and pH changes, an empiric model of the interaction of Mg alloy with PLA nanofibers is proposed. Magnesium 104-106 phenylalanine hydroxylase Homo sapiens 53-55 35389104-0 2022 Structural mechanism of TRPM7 channel regulation by intracellular magnesium. Magnesium 66-75 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 24-29 35193162-6 2022 ABSTRACT: Increased extracellular magnesium concentration has been shown to attenuate the endothelin-1-induced contractile response via the release of nitric oxide (NO) from the endothelium in proximal pulmonary arteries (PAs) of chronic hypoxic mice. Magnesium 34-43 endothelin 1 Mus musculus 90-102 35443355-5 2022 Also, Magnesium is required for insulin secretion and for proper insulin functioning via tyrosine kinase activity at the receptor level. Magnesium 6-15 insulin Homo sapiens 32-39 35114835-9 2022 The expression of smad2 in Mg-6Zn alloy group maintained a steady level, while in titanium alloy group it showed a general upward trend. Magnesium 27-29 mothers against decapentaplegic homolog 2 Oryctolagus cuniculus 18-23 35114835-10 2022 The expression of smad3 in both groups held steady after 2 weeks, then in the third week, it showed a strong uptrend in Mg-6Zn alloy group, while decreased immediately in titanium alloy group. Magnesium 120-122 mothers against decapentaplegic homolog 3 Oryctolagus cuniculus 18-23 35443355-5 2022 Also, Magnesium is required for insulin secretion and for proper insulin functioning via tyrosine kinase activity at the receptor level. Magnesium 6-15 insulin Homo sapiens 65-72 35482380-2 2022 To increase the Ca and Mg contents in the drinking water supplied to the inhabitants of the village of Devicie, a prototype of a fluidized bed recarbonization reactor (RRF) was proposed and tested. Magnesium 23-25 mitochondrial ribosome recycling factor Homo sapiens 168-171 35385223-0 2022 Fibroblast growth factor-23 and parathyroid hormone suppress small intestinal magnesium absorption. Magnesium 78-87 fibroblast growth factor 23 Rattus norvegicus 0-27 35385223-0 2022 Fibroblast growth factor-23 and parathyroid hormone suppress small intestinal magnesium absorption. Magnesium 78-87 parathyroid hormone Rattus norvegicus 32-51 35425790-2 2022 Meanwhile, the role of magnesium is important in the synthesis of Vit D, since it is an essential element for activating Vit D. Nevertheless, there remains insufficient studies concerning whether dietary Magnesium intake influences the association between Vit D and risk of pancreatic beta-cell dysfunction. Magnesium 23-32 vitrin Homo sapiens 66-69 35313343-1 2022 An experimental investigation into the possibility of dose-rate effects and wall scatter in the thermoluminescent response of LiF:Mg,Ti (TLD-100) was carried out. Magnesium 130-132 LIF interleukin 6 family cytokine Homo sapiens 126-129 35313343-9 2022 The results are encouraging with respect to the accurate and reproducible use of LiF:Mg,Ti under various experimental conditions of irradiation. Magnesium 85-87 LIF interleukin 6 family cytokine Homo sapiens 81-84 35415073-7 2022 Conclusion: Biodegradable Mg implant could alleviate the development of MRONJ-like lesion, possibly via upregulating VEGF- and CGRP-mediated angiogenesis. Magnesium 26-28 vascular endothelial growth factor A Rattus norvegicus 117-121 35415073-7 2022 Conclusion: Biodegradable Mg implant could alleviate the development of MRONJ-like lesion, possibly via upregulating VEGF- and CGRP-mediated angiogenesis. Magnesium 26-28 calcitonin-related polypeptide alpha Rattus norvegicus 127-131 35346774-7 2022 Compared with placebo, magnesium plus bupivacaine was most likely to be effective in relieving pain at both 2-hour (SMD=-3.81, 95%CrI: -5.28 to -2.35) and 24-hour after surgery (SMD=-2.81, 95%CrI: -4.29 to -1.30). Magnesium 23-32 small nuclear ribonucleoprotein D3 polypeptide Homo sapiens 116-122 35346774-7 2022 Compared with placebo, magnesium plus bupivacaine was most likely to be effective in relieving pain at both 2-hour (SMD=-3.81, 95%CrI: -5.28 to -2.35) and 24-hour after surgery (SMD=-2.81, 95%CrI: -4.29 to -1.30). Magnesium 23-32 small nuclear ribonucleoprotein D2 polypeptide Homo sapiens 178-184 35453514-5 2022 Our results showed that the combination of copper and dex strongly decreased the expression of pro-inflammatory markers, while the combination with magnesium upregulated the expression of IL-10. Magnesium 148-157 interleukin 10 Homo sapiens 188-193 35234763-0 2022 Few-layer Mg-deficient borophene nanosheets: I2 oxidation and ultrasonic delamination from MgB2. Magnesium 10-12 secretoglobin family 2A member 1 Homo sapiens 91-95 35234763-3 2022 The acidity of the reaction system plays an important role; the HCl reaction system not only facilitates the oxidation of MgB2 by I2, but also increases the deintercalation ratio of Mg atoms. Magnesium 182-184 secretoglobin family 2A member 1 Homo sapiens 122-126 35371166-4 2022 GUN4 interacts with magnesium chelatase (MgCh), and its binding of the catalytic substrate and product of the MgCh reaction stimulates the insertion of Mg2+ into protoporphyrin IX. Magnesium 20-29 protein GENOMES UNCOUPLED 4 Arabidopsis thaliana 0-4 35238559-4 2022 Interestingly, as 64% of Li and 26% of Gd at the RE3 and RE2 sites, respectively, were exclusively substituted by Mg in Gd3.47(1)Li0.36(2)Mg1.17(3)Ge4, the lattice parameter b was selectively shortened as a result of the RE3-Ge1 bond shrinkage in comparison to that in Gd4LiGe4, while lattice parameters a and c remained nearly intact. Magnesium 114-116 GRDX Homo sapiens 120-123 35329527-0 2022 Effect of the Ca2Mg6Zn3 Phase on the Corrosion Behavior of Biodegradable Mg-4.0Zn-0.2Mn-xCa Alloys in Hank"s Solution. Magnesium 73-75 X chromosome controlling element Homo sapiens 88-91 35329527-1 2022 The effect of the Ca2Mg6Zn3 phase on the corrosion behavior of biodegradable Mg-4.0Zn-0.2Mn-xCa (ZM-xCa, x = 0.1, 0.3, 0.5 and 1.0 wt.%) alloys in Hank"s solution was investigated with respect to phase spacing, morphology, distribution and volume fraction. Magnesium 77-79 X chromosome controlling element Homo sapiens 92-95 35329527-1 2022 The effect of the Ca2Mg6Zn3 phase on the corrosion behavior of biodegradable Mg-4.0Zn-0.2Mn-xCa (ZM-xCa, x = 0.1, 0.3, 0.5 and 1.0 wt.%) alloys in Hank"s solution was investigated with respect to phase spacing, morphology, distribution and volume fraction. Magnesium 77-79 X chromosome controlling element Homo sapiens 100-103 35132991-5 2022 FABP-inhibition induces distinct changes in single cell transcriptomic profiles indicating transitions of MG from resting to reactive states and suppressed MGPC formation, with upregulation of gene modules for gliogenesis and decreases in neurogenesis. Magnesium 106-108 fatty acid binding protein 2 Gallus gallus 0-4 35425790-2 2022 Meanwhile, the role of magnesium is important in the synthesis of Vit D, since it is an essential element for activating Vit D. Nevertheless, there remains insufficient studies concerning whether dietary Magnesium intake influences the association between Vit D and risk of pancreatic beta-cell dysfunction. Magnesium 23-32 vitrin Homo sapiens 121-124 35425790-3 2022 Hence, this cross-sectional study aimed to assess the effect of Magnesium intake alterations on the association between serum Vit D levels and the risk of pancreatic beta-cell dysfunction. Magnesium 64-73 vitrin Homo sapiens 126-129 35425790-9 2022 Conclusion: According to the results of this study, the dietary Magnesium intake influences the associations of serum Vit D levels with HOMA-beta index and pancreatic beta-cell dysfunction. Magnesium 64-73 vitrin Homo sapiens 118-121 34998549-6 2022 Compared with the control group, feeding the magnesium-supplemented diets increased milk fat concentration and yield by 12% within 4 d. During the 20-d Mg-supplementation period, both the MG and CMC diets increased milk fat concentration and yield, as well as 3.5% fat-corrected milk and energy-corrected milk yield, without affecting dry matter intake, milk yield, and milk protein and lactose concentrations. Magnesium 45-54 casein beta Bos taurus 370-382 35090980-11 2022 However, the expressions of antioxidant genes (SOD, catalase, and GPX) and apoptotic genes (Bcl-2 and Caspase-3) were significantly reduced in MG treated F1 rats when compared to disease control rats. Magnesium 143-145 catalase Rattus norvegicus 52-60 35090980-11 2022 However, the expressions of antioxidant genes (SOD, catalase, and GPX) and apoptotic genes (Bcl-2 and Caspase-3) were significantly reduced in MG treated F1 rats when compared to disease control rats. Magnesium 143-145 BCL2, apoptosis regulator Rattus norvegicus 92-97 35090980-11 2022 However, the expressions of antioxidant genes (SOD, catalase, and GPX) and apoptotic genes (Bcl-2 and Caspase-3) were significantly reduced in MG treated F1 rats when compared to disease control rats. Magnesium 143-145 caspase 3 Rattus norvegicus 102-111 35241813-2 2022 OT acts through the oxytocin receptor (OTR), a magnesium-dependent G protein-coupled receptor that is a therapeutic target for treatment of postpartum hemorrhage, dysfunctional labor and autism. Magnesium 47-56 oxytocin receptor Homo sapiens 20-37 35241813-2 2022 OT acts through the oxytocin receptor (OTR), a magnesium-dependent G protein-coupled receptor that is a therapeutic target for treatment of postpartum hemorrhage, dysfunctional labor and autism. Magnesium 47-56 oxytocin receptor Homo sapiens 39-42 35197297-6 2022 Glial cell-specific PAD4 deficiency attenuates retinal hypercitrullination in injured retinas, indicating PAD4 requirement for MG citrullination. Magnesium 127-129 peptidyl arginine deiminase 4 Homo sapiens 20-24 35197297-6 2022 Glial cell-specific PAD4 deficiency attenuates retinal hypercitrullination in injured retinas, indicating PAD4 requirement for MG citrullination. Magnesium 127-129 peptidyl arginine deiminase 4 Homo sapiens 106-110 35424624-3 2022 The hydrolysis performances of Mg-based materials (Mg, MgH2, MgH2-BM and MgH2-RBM) with water are effectively improved under light-activation. Magnesium 31-33 RNA binding motif protein Y-linked family 2 member D, pseudogene Homo sapiens 78-81 35182234-4 2022 Furthermore, we challenge the possibility that supplementation with magnesium restores NKG2D levels and show that the addition of this ion does not significantly improve NKG2D steady-state expression nor does it rescue the hypoglycosylation defect in CRISPR-engineered human cell lines. Magnesium 68-77 killer cell lectin like receptor K1 Homo sapiens 87-92 35051368-0 2022 Magnesium sensing via LFA-1 regulates CD8+ T cell effector function. Magnesium 0-9 integrin subunit alpha L Homo sapiens 22-27 35051368-2 2022 Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to adopt its active conformation on CD8+ T cells, thereby augmenting calcium flux, signal transduction, metabolic reprogramming, immune synapse formation, and, as a consequence, specific cytotoxicity. Magnesium 75-84 integrin subunit alpha L Homo sapiens 60-65 35456652-6 2022 The most promising materials were magnesium aluminometasilicates, specifically Neusilin US2, due to its proper flow, large SSA, etc. Magnesium 34-43 usherin Homo sapiens 89-92 35207588-4 2022 The best mica for life"s origins is the black mica, biotite, because it has a high content of Mg++ and because it has iron in various oxidation states. Magnesium 94-98 MHC class I polypeptide-related sequence A Homo sapiens 9-13 35207588-4 2022 The best mica for life"s origins is the black mica, biotite, because it has a high content of Mg++ and because it has iron in various oxidation states. Magnesium 94-98 MHC class I polypeptide-related sequence A Homo sapiens 46-50 35204586-6 2022 In this pilot study, univariate, multivariate and Poisson regression analysis, show that low levels of GRP and magnesium (Mg), and high levels of phosphate (P) are associated with mitral and aortic valves calcification. Magnesium 122-124 upper zone of growth plate and cartilage matrix associated Homo sapiens 103-106 35198253-7 2022 MAGT1 is an evolutionarily conserved, magnesium-specific transporter expressed in all mammalian cells that plays an essential role in magnesium homeostasis. Magnesium 38-47 magnesium transporter 1 Homo sapiens 0-5 35198253-7 2022 MAGT1 is an evolutionarily conserved, magnesium-specific transporter expressed in all mammalian cells that plays an essential role in magnesium homeostasis. Magnesium 134-143 magnesium transporter 1 Homo sapiens 0-5 35223805-5 2022 The results of attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy showed that a dense and compact coating was created on the magnesium alloy surface. Magnesium 226-235 ATR serine/threonine kinase Homo sapiens 84-87 35207817-0 2022 Microstructure and Phase Evolution Characteristics of the In Situ Synthesis of TiC-Reinforced AZ91D Magnesium Matrix Composites. Magnesium 100-109 pleckstrin and Sec7 domain containing 4 Homo sapiens 79-82 35207817-1 2022 TiC-reinforced AZ91D magnesium alloy composites were synthesized through the in situ reaction between an AZ91D melt and Ti-C-Al preforms. Magnesium 21-30 pleckstrin and Sec7 domain containing 4 Homo sapiens 0-3 35277037-9 2022 In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. Magnesium 18-20 C-reactive protein Homo sapiens 67-85 35277037-9 2022 In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. Magnesium 18-20 C-reactive protein Homo sapiens 87-90 35277037-10 2022 In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1. Magnesium 25-27 fibrinogen beta chain Homo sapiens 73-83 35277037-10 2022 In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1. Magnesium 25-27 acid phosphatase 5, tartrate resistant Homo sapiens 85-180 35277037-10 2022 In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1. Magnesium 25-27 ST2 Homo sapiens 182-185 35277037-11 2022 In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels. Magnesium 15-17 C-reactive protein Homo sapiens 117-120 35186909-4 2022 As determined with in vitro experiments, Mg-HA-C/C composites containing 10 and 20% Mg decreased miR-16 levels, increased cell viability, elevated the levels of osteogenesis-related genes, and promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) seeded on their surfaces. Magnesium 84-86 microRNA 16 Rattus norvegicus 97-103 35087208-4 2022 We show that the yeast genome (as well as other fungal genomes) harbour a single ACDP homologue, referred to as MAM3, that functions specifically in vacuolar Mg2+ accumulation and is essential for tolerance to high Mg. Magnesium 215-217 Mam3p Saccharomyces cerevisiae S288C 112-116 35051368-3 2022 Accordingly, magnesium-sufficiency sensed via LFA-1 translated to the superior performance of pathogen- and tumor-specific T cells, enhanced effectiveness of bi-specific T cell engaging antibodies, and improved CAR T cell function. Magnesium 13-22 integrin subunit alpha L Homo sapiens 46-51 35051368-6 2022 These findings conceptually link co-stimulation and nutrient sensing and point to the magnesium-LFA-1 axis as a therapeutically amenable biologic system. Magnesium 86-95 integrin subunit alpha L Homo sapiens 96-101 35145426-8 2021 Impeding Mg-binding to the RyR activation site enhanced spark formation and speeded up their activation. Magnesium 9-11 ryanodine receptor 2 Homo sapiens 27-30 35163580-0 2022 Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters. Magnesium 0-9 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 79-84 35163580-0 2022 Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters. Magnesium 0-9 magnesium transporter 1 Mus musculus 86-91 35163580-0 2022 Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters. Magnesium 0-9 solute carrier family 41, member 1 Mus musculus 96-103 35163580-3 2022 The level of the Mg transporter MagT1 decreases at early time points and is restored at the end of the process, suggesting a possible role in the regulation of intracellular Mg concentration. Magnesium 174-176 magnesium transporter 1 Mus musculus 32-37 35153759-0 2021 Magnesium-Assisted Cisplatin Inhibits Bladder Cancer Cell Survival by Modulating Wnt/beta-Catenin Signaling Pathway. Magnesium 0-9 catenin beta 1 Homo sapiens 85-97 35153759-7 2021 6-bromoindirubin-3"-oxime (BIO), an inhibitor of glycogen synthase kinase-3 (GSK-3) that activates the Wnt/beta-catenin signaling pathway by modulating beta-catenin activity, was thus applied to further exploit the role of this signaling pathway in magnesium aided cancer treatment. Magnesium 249-258 catenin beta 1 Homo sapiens 107-119 35153759-7 2021 6-bromoindirubin-3"-oxime (BIO), an inhibitor of glycogen synthase kinase-3 (GSK-3) that activates the Wnt/beta-catenin signaling pathway by modulating beta-catenin activity, was thus applied to further exploit the role of this signaling pathway in magnesium aided cancer treatment. Magnesium 249-258 catenin beta 1 Homo sapiens 152-164 35153759-11 2021 Our findings reveal that magnesium could contribute to cisplatin-based chemotherapy by moderately regulating the Wnt/beta-catenin signaling pathway. Magnesium 25-34 catenin beta 1 Homo sapiens 117-129 35060008-10 2022 Magnesium may also regulate TRPM6/7, promote the secretion of klotho protein and improve renal fibrosis. Magnesium 0-9 transient receptor potential cation channel subfamily M member 6 Homo sapiens 28-35 35060008-10 2022 Magnesium may also regulate TRPM6/7, promote the secretion of klotho protein and improve renal fibrosis. Magnesium 0-9 klotho Homo sapiens 62-68 35480861-0 2022 Yes-associated protein contributes to magnesium alloy-derivedinflammation in endothelial cells. Magnesium 38-47 Yes1 associated transcriptional regulator Homo sapiens 0-22 35480861-4 2022 Quantitative RT-PCR, western blotting and immunofluorescence staining showed that Mg alloy inhibited the Hippo pathway to facilitate nuclear shuttling and activation of YAP in human coronary artery endothelial cells (HCAECs). Magnesium 82-84 Yes1 associated transcriptional regulator Homo sapiens 169-172 35145426-11 2021 The characteristics of CREs correlated dose-dependently with the effective coupling strength between RyRs, defined as a function of RyR vicinity, single-channel calcium current, and Mg-binding parameters of the RyR channels. Magnesium 182-184 ryanodine receptor 2 Homo sapiens 211-214 34988572-0 2022 Sustainable and cost-effective ternary electrolyte Et3NHCl-AlCl3-Mg(DEP)2 for high-performance rechargeable magnesium batteries. Magnesium 108-117 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 Homo sapiens 68-73 35582188-1 2022 Background: Previous studies have reported that sodium-glucose co-transporter 2 (SGLT2) inhibitors (SGLT2is) affect levels of serum electrolytes, especially magnesium. Magnesium 157-166 solute carrier family 5 member 2 Homo sapiens 48-79 35582188-1 2022 Background: Previous studies have reported that sodium-glucose co-transporter 2 (SGLT2) inhibitors (SGLT2is) affect levels of serum electrolytes, especially magnesium. Magnesium 157-166 solute carrier family 5 member 2 Homo sapiens 81-86 35582188-1 2022 Background: Previous studies have reported that sodium-glucose co-transporter 2 (SGLT2) inhibitors (SGLT2is) affect levels of serum electrolytes, especially magnesium. Magnesium 157-166 solute carrier family 5 member 2 Homo sapiens 100-105 35582188-3 2022 Methods: We systematically searched PubMed, EMBASE, CENTRAL, and ClinicalTrials.gov up to January 2021 to identify eligible randomized controlled trials (RCTs) of SGLT2is that reported mean changes in serum electrolytes, including magnesium, sodium, potassium, phosphate, and calcium. Magnesium 231-240 solute carrier family 5 member 2 Homo sapiens 163-168 34988572-3 2022 The optimized ratio of the 0.1 M Mg(DEP)2 electrolyte has shown a high ionic conductivity of 4.5 x 10-3 S cm-1 at ambient temperature and good anodic stability of 2.41 V vs. Mg/Mg2+. Magnesium 174-176 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 Homo sapiens 36-41 35582188-6 2022 Compared with placebo, SGLT2is were significantly associated with elevations in serum magnesium by 0.07 mmol/L (95% CI, 0.06 to 0.08 mmol/L) and serum phosphate by 0.03 mmol/L (95% CI, 0.02 to 0.04 mmol/L). Magnesium 86-95 solute carrier family 5 member 2 Homo sapiens 23-28 35582188-9 2022 Conclusions: SGLT2is significantly increased serum magnesium and phosphate levels, consistent with a class effect of SGLT2 inhibition. Magnesium 51-60 solute carrier family 5 member 2 Homo sapiens 13-18 35582188-9 2022 Conclusions: SGLT2is significantly increased serum magnesium and phosphate levels, consistent with a class effect of SGLT2 inhibition. Magnesium 51-60 solute carrier family 5 member 2 Homo sapiens 117-122 34655400-2 2022 The original studies of XMEN patients focused on impaired magnesium regulation, leading to decreased EBV-cytotoxicity and the loss of surface expression of the activating receptor "natural killer group 2D" (NKG2D) on CD8+ T cells and NK cells. Magnesium 58-67 magnesium transporter 1 Homo sapiens 24-28 35160641-0 2022 Diffusion Bonding of Al-Mg-Si Alloy and 301L Stainless Steel by Friction Stir Lap Welding Using a Zn Interlayer. Magnesium 24-26 LAP Homo sapiens 78-81 35163850-4 2022 The spatial and electronic changes occurring in the MOF after the interaction with Li, Na and Mg are discussed on the basis of calculated electrode potentials versus Li0/Li+, Na0/Na+ and Mg0/Mg2+, respectively. Magnesium 94-96 lysine acetyltransferase 8 Homo sapiens 52-55 35602976-4 2022 We found 5 molecules (Mg-132, Z-FA-FMK, leupeptin hemisulfate, Mg-101 and calpeptin) that were able to significantly inhibit the activity of CTSL in the nanomolar range and inhibit the infection of both pseudotype and live SARS-CoV-2. Magnesium 22-24 cathepsin L Homo sapiens 141-145 34655400-2 2022 The original studies of XMEN patients focused on impaired magnesium regulation, leading to decreased EBV-cytotoxicity and the loss of surface expression of the activating receptor "natural killer group 2D" (NKG2D) on CD8+ T cells and NK cells. Magnesium 58-67 killer cell lectin like receptor K1 Homo sapiens 207-212 35307056-14 2022 Pearson correlation analysis showed that the blood magnesium level of sepsis patients was negatively correlated with PCT (r = -0.173, P < 0.05), and it was positively correlated with APACHE II score (r = 0.159, P < 0.05), but it had no correlation with CRP or SOFA score (r values were -0.029 and 0.091, both P > 0.05). Magnesium 51-60 C-reactive protein Homo sapiens 253-256 35067491-8 2022 MAGL knockdown significantly impeded the proliferation, clone formation, invasion and migration of MG-63 cells, whereas opposite result was observed in 143B cells with MAGL overexpression. Magnesium 99-101 monoglyceride lipase Homo sapiens 0-4 2582618-0 1989 Enzymatic assay of magnesium through glucokinase activation. Magnesium 19-28 glucokinase Homo sapiens 37-48 2573599-5 1989 This finding supports the original hypothesis that the presence of Asp at sequence position 59 is an important factor in the reduced preference of the CD site of oncomodulin for smaller metals such as magnesium (Williams, T. C., Corson, D. C., Sykes, B. D., and MacManus, J. P. (1987) J. Biol. Magnesium 201-210 oncomodulin Rattus norvegicus 162-173 2601885-0 1989 Chloride and magnesium dependence of vasopressin release from rat permeabilized neurohypophysial nerve endings. Magnesium 13-22 arginine vasopressin Rattus norvegicus 37-48 2601885-1 1989 The role of Cl- and Mg+ ions has been studied on the secretory mechanism leading to the release of vasopressin from digitonin permeabilized nerve endings isolated from the rat neurohypophysis. Magnesium 20-23 arginine vasopressin Rattus norvegicus 99-110 2693735-4 1989 The latter "short pitch" helix is also observed in pure RecA protein polymers (also termed rods) and in the needle-like paracrystals of RecA protein that form in the presence of magnesium or spermidine ions, representing bundles of rods closely packed in register. Magnesium 178-187 RAD51 recombinase Homo sapiens 136-140 2603942-0 1989 Effect of magnesium and preeclampsia on plasma cholinesterase activity. Magnesium 10-19 butyrylcholinesterase Homo sapiens 47-61 2480352-5 1989 Magnesium greatly enhances the binding of these antibodies to myosin, showing that the conformation of the heavy chain in the neck region changes upon divalent cation binding to the regulatory light chain. Magnesium 0-9 myosin heavy chain 14 Homo sapiens 62-68 2693419-5 1989 Parathyroid hormone (PTH) can affect Mg metabolism by decreasing urinary Mg excretion and stimulating bone resorption, thus releasing Mg into the extracellular fluid. Magnesium 37-39 parathyroid hormone Homo sapiens 0-19 2693419-5 1989 Parathyroid hormone (PTH) can affect Mg metabolism by decreasing urinary Mg excretion and stimulating bone resorption, thus releasing Mg into the extracellular fluid. Magnesium 37-39 parathyroid hormone Homo sapiens 21-24 2693419-5 1989 Parathyroid hormone (PTH) can affect Mg metabolism by decreasing urinary Mg excretion and stimulating bone resorption, thus releasing Mg into the extracellular fluid. Magnesium 73-75 parathyroid hormone Homo sapiens 0-19 2693419-5 1989 Parathyroid hormone (PTH) can affect Mg metabolism by decreasing urinary Mg excretion and stimulating bone resorption, thus releasing Mg into the extracellular fluid. Magnesium 73-75 parathyroid hormone Homo sapiens 21-24 2693419-5 1989 Parathyroid hormone (PTH) can affect Mg metabolism by decreasing urinary Mg excretion and stimulating bone resorption, thus releasing Mg into the extracellular fluid. Magnesium 73-75 parathyroid hormone Homo sapiens 0-19 2693419-5 1989 Parathyroid hormone (PTH) can affect Mg metabolism by decreasing urinary Mg excretion and stimulating bone resorption, thus releasing Mg into the extracellular fluid. Magnesium 73-75 parathyroid hormone Homo sapiens 21-24 2584753-0 1989 Influence of magnesium concentration on production of exoprotein and beta-lactamase by Staphylococcus aureus and Staphylococcus hemolyticus. Magnesium 13-22 beta-lactamase Staphylococcus aureus 69-83 2584753-2 1989 This investigation studied the influence of magnesium concentration on production of total exoprotein and beta-lactamase by strains of S. aureus and Staphylococcus hemolyticus, isolated from the genital tracts of women. Magnesium 44-53 beta-lactamase Staphylococcus aureus 106-120 2584753-5 1989 In all strains, total exoprotein production and beta-lactamase activity per bacterial cell were markedly increased in the presence of low concentrations of magnesium. Magnesium 156-165 beta-lactamase Staphylococcus aureus 48-62 2584753-6 1989 When the concentration of magnesium was elevated, production of total exoprotein and beta-lactamase was decreased. Magnesium 26-35 beta-lactamase Staphylococcus aureus 85-99 2555340-6 1989 Excess pyrophosphate as well as excess magnesium inhibited the pyrophosphatase. Magnesium 39-48 pyrophosphate-energized vacuolar membrane proton pump Vigna radiata 63-78 2556274-6 1989 In contrast, magnesium but not neomycin largely enhanced the potency of guanine nucleotides, particularly of GTP and its analog, guanosine-5"-O-(3-thiotriphosphate), to reduce fMet-Leu-Phe receptor binding, while maximal inhibition of agonist receptor binding by guanine nucleotides was identical with magnesium and neomycin. Magnesium 13-22 formyl peptide receptor 1 Homo sapiens 176-197 2556274-6 1989 In contrast, magnesium but not neomycin largely enhanced the potency of guanine nucleotides, particularly of GTP and its analog, guanosine-5"-O-(3-thiotriphosphate), to reduce fMet-Leu-Phe receptor binding, while maximal inhibition of agonist receptor binding by guanine nucleotides was identical with magnesium and neomycin. Magnesium 302-311 formyl peptide receptor 1 Homo sapiens 176-197 2582618-2 1989 Magnesium participates as an Mg.ATP complex in a reaction catalyzed by glucokinase (EC 2.7.1.2) coupled to an NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49) reaction. Magnesium 0-9 glucokinase Homo sapiens 71-82 2582618-3 1989 The increase of absorbance at 340 nm, due to the NADPH produced, is proportional to the amount of the activated glucokinase, which in turn is related to the concentration of magnesium in the sample. Magnesium 174-183 glucokinase Homo sapiens 112-123 2594163-9 1989 When the synaptic connections between the pyramidal cells and interneurons were disrupted by local application of magnesium or bicuculline, met-enkephalin had no effect on the pyramidal cells. Magnesium 114-123 proopiomelanocortin Homo sapiens 140-154 2810505-0 1989 Magnesium-to-calcium ratio in tap water, and its relationship to geological features and the incidence of calcium-containing urinary stones. Magnesium 0-9 nuclear RNA export factor 1 Homo sapiens 30-33 2810505-2 1989 The magnesium-to-calcium ratio in tap water correlated negatively with the incidence of urolithiasis. Magnesium 4-13 nuclear RNA export factor 1 Homo sapiens 34-37 2810505-9 1989 Thus, the incidence of urinary stone is related to the magnesium-to-calcium ratio in tap water and the geological area. Magnesium 55-64 nuclear RNA export factor 1 Homo sapiens 85-88 2529059-12 1989 Urinary magnesium excretion was significantly increased during ANF infusion from phase 1 (p less than 0.02), whereas urinary potassium levels, calcium levels, creatinine levels, volume, and glomerular filtration rate did not differ significantly between the two infusions. Magnesium 8-17 natriuretic peptide A Homo sapiens 63-66 2689872-3 1989 We have now identified a factor in the yeast Saccharomyces cerevisiae that shares many properties with XPE binding factor, including cellular location, abundance, magnesium dependence, and relative affinities for multiple forms of damaged DNA. Magnesium 163-172 damage specific DNA binding protein 1 Homo sapiens 103-121 2478135-3 1989 The S10 protein antigen was readily extracted from ribosomes at low salt (300 mM KCl) and low magnesium (0.5 mM) concentrations, consistent with the highly exposed location proposed for this protein on the 40S subunit. Magnesium 94-103 ribosomal protein S10 Homo sapiens 4-7 2789853-2 1989 Eosinophil numbers and LPL activity in lung tissue following infection with A. suum larvae were altered by the level of magnesium in the diets of mice. Magnesium 120-129 lipoprotein lipase Mus musculus 23-26 2789853-5 1989 Larvae/livers, eosinophil numbers, and LPL activity were affected by the types of magnesium diets that mice received. Magnesium 82-91 lipoprotein lipase Mus musculus 39-42 2584591-3 1989 Also, it introduces the hypothesis that magnesium deficiency could affect pathologically the osmotic mechanism of the cornea, specifically the Na-K and/or Ca-ATPase pumps; the collagen structure by alteration of the adenylate cyclase activity; and other mechanisms as well. Magnesium 40-49 TANK binding kinase 1 Homo sapiens 143-152 2573406-5 1989 The SS-14-induced membrane hyperpolarization was not blocked by naloxone, bicuculline, tetrodotoxin, or calcium-free, high-magnesium superfusion media. Magnesium 123-132 somatostatin Rattus norvegicus 4-9 2573406-6 1989 In a small number of neurons, SS-14 application produced a membrane depolarization which did not exhibit clear concentration-dependence and was blocked by superfusion of calcium-free, high-magnesium media indicating an indirect action. Magnesium 189-198 somatostatin Rattus norvegicus 30-35 2572997-5 1989 It persisted in low-calcium, high-magnesium solutions (N = 5) and therefore probably resulted from a direct activation of neurotensin receptors. Magnesium 34-43 neurotensin Rattus norvegicus 122-133 2670954-7 1989 Within hours of replating at confluent density in Ca++/Mg++-containing media, attached cells show discrete localization of ZO-1 at cell-cell contacts. Magnesium 55-59 tight junction protein 1 Homo sapiens 123-127 2547780-13 1989 In broken Balb/c3T3 cell membranes, 10 nM IGF-II rapidly attenuated the IAP-catalyzed ADP-ribosylation of a 40-kDa protein in a manner requiring magnesium ion. Magnesium 145-154 insulin-like growth factor 2 Mus musculus 42-48 2547780-13 1989 In broken Balb/c3T3 cell membranes, 10 nM IGF-II rapidly attenuated the IAP-catalyzed ADP-ribosylation of a 40-kDa protein in a manner requiring magnesium ion. Magnesium 145-154 intracisternal A particle, Eya1 linked Mus musculus 72-75 2788460-3 1989 An LMM fragment (Mr 62,000) of myosin has been prepared which has aggregation properties that are sensitive to the presence of Mg.ATP. Magnesium 127-129 myosin heavy chain 14 Homo sapiens 31-37 2788460-7 1989 Although assembly of the rod fragment of myosin into paracrystals does not show sensitivity to Mg.ATP, assembly of intact myosin molecules to form filaments does show sensitivity to Mg.ATP. Magnesium 182-184 myosin heavy chain 14 Homo sapiens 41-47 2788460-7 1989 Although assembly of the rod fragment of myosin into paracrystals does not show sensitivity to Mg.ATP, assembly of intact myosin molecules to form filaments does show sensitivity to Mg.ATP. Magnesium 182-184 myosin heavy chain 14 Homo sapiens 122-128 2788460-9 1989 The rearrangement of the LMM rods and intact myosin molecules both induced by the presence of Mg.ATP are probably related. Magnesium 94-96 myosin heavy chain 14 Homo sapiens 45-51 2550340-3 1989 Dietary Ca and Mg supplementation, likewise, produced significant decrease in GPC diesterase activity. Magnesium 15-17 glycophorin C Rattus norvegicus 78-81 2548622-6 1989 Thrombin-induced platelet aggregation was only partial in the absence of external calcium, even if excess magnesium was present in the media, while the aggregation response became complete if external calcium was repleted. Magnesium 106-115 coagulation factor II, thrombin Homo sapiens 0-8 2555646-0 1989 Effect of magnesium deficiency on delta 6 desaturase activity and fatty acid composition of rat liver microsomes. Magnesium 10-19 fatty acid desaturase 2 Rattus norvegicus 34-52 2775754-3 1989 The characteristics of the fluorescence decays are strongly dependent upon the number of calcium ions bound per molecule of VU-9 calmodulin until half of the calcium sites are occupied, i.e., three in the absence of magnesium and two in the presence of 5 mM magnesium. Magnesium 258-267 calmodulin 1 Homo sapiens 129-139 2546544-4 1989 Incubation of the immunopurified protein-A-Sepharose-adsorbed PR with the catalytic subunit of cAMP-PK in the presence of gamma-[32P]ATP and divalent cations resulted in a Mg++-dependent incorporation of 32P-radioactivity into both the 114 kDa and the hsp-90 peptides. Magnesium 172-176 progesterone receptor Bos taurus 62-64 2769749-12 1989 The inhibitor polyols are bound in the active site in an extended open chain conformation and complete an octahedral co-ordination shell for the magnesium cation via their oxygen atoms O-2 and O-4. Magnesium 145-154 immunoglobulin kappa variable 1D-39 Homo sapiens 185-196 2662695-0 1989 Dietary magnesium supplements improve B-cell response to glucose and arginine in elderly non-insulin dependent diabetic subjects. Magnesium 8-17 insulin Homo sapiens 93-100 2662695-6 1989 Dietary magnesium supplementation vs placebo produced a slight but significant decrease in basal plasma glucose (8.6 +/- 0.3 vs 8.0 +/- 0.1 mmol/l, p less than 0.05) and an increase in acute insulin response after iv glucose (3.7 +/- 2.3 vs - 14.7 +/- 0.9 pmol.l 1. Magnesium 8-17 insulin Homo sapiens 191-198 2662695-10 1989 Net increase in acute insulin response after iv glucose and after iv arginine was significantly correlated to the net increase in erythrocyte magnesium content after dietary magnesium supplementation. Magnesium 142-151 insulin Homo sapiens 22-29 2662695-10 1989 Net increase in acute insulin response after iv glucose and after iv arginine was significantly correlated to the net increase in erythrocyte magnesium content after dietary magnesium supplementation. Magnesium 174-183 insulin Homo sapiens 22-29 2662695-11 1989 We conclude that magnesium administration may be a useful adjuvant to the classic hypoglycemic agents in the treatment of non-insulin-dependent diabetic subjects. Magnesium 17-26 insulin Homo sapiens 126-133 2733941-2 1989 In magnesium deficiency states, parathyroid hormone and calcitriol secretion may be decreased. Magnesium 3-12 parathyroid hormone Homo sapiens 32-51 2620574-2 1989 Mean maternal serum values of Ca, Mg, Cu and Zn in the PIH group were 2.460 mmol/L, 0.839 mmol/L, 35.094 mol/L and 8.408 mumol/L,respectively and were compared with the corresponding Values of 2.765 mmol/L, 0.834 mmol/L, 31.486 mumol/L, and 9.657 mumol/L in the controls. Magnesium 34-36 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 55-58 2542339-3 1989 The polylysine-dependent insulin stimulation of protein kinase activity required the presence of both magnesium and manganese but at relatively low divalent metal ion concentrations (0.1 mM) compared to the typical 2-10 mM Mg/Mn used in the standard in vitro kinase assays. Magnesium 102-111 insulin Homo sapiens 25-32 2729996-5 1989 Similar titrations with magnesium or strontium demonstrate that the metal binding site of cystatin exhibits specificity for calcium or terbium. Magnesium 24-33 cystatin C Gallus gallus 90-98 2751688-0 1989 Transfer-RNA, magnesium and the formation of ternary complexes by eukaryotic initiation factor eIF-2. Magnesium 14-23 eukaryotic translation initiation factor 2 subunit beta Homo sapiens 95-100 2751688-1 1989 The likely concentrations of free magnesium ions in assay systems measuring ternary complex formation with the eukaryotic initiation factor eIF-2 and the exchange of bound GDP have been calculated. Magnesium 34-43 eukaryotic translation initiation factor 2 subunit beta Homo sapiens 140-145 2542856-4 1989 Magnesium infusion was associated with a sustained decline in plasma renin activity in preeclamptic women (P = .003). Magnesium 0-9 renin Homo sapiens 69-74 2660287-1 1989 We studied the relationships between the renin-angiotensin-aldosterone system and calcium and magnesium levels in both serum and urine in 51 volunteer normotensive subjects, divided into two groups. Magnesium 94-103 renin Homo sapiens 41-46 2712576-15 1989 High concentrations of phosphate with magnesium were found to protect enzyme activity when PEPC, previously shown to contain an essential arginine at the active site, was incubated with the specific arginyl reagent 2,3-butanedione, consistent with the binding of phosphate at the active site. Magnesium 38-47 phosphoenolpyruvate carboxykinase 1 Homo sapiens 91-95 2719498-4 1989 We found a 13% increase in molar ratio of apolipoprotein A1:apolipoprotein B after magnesium treatment, as compared with a 2% increase in the placebo group (for mean differences between changes of the magnesium and the placebo groups). Magnesium 83-92 apolipoprotein A1 Homo sapiens 42-59 2719498-4 1989 We found a 13% increase in molar ratio of apolipoprotein A1:apolipoprotein B after magnesium treatment, as compared with a 2% increase in the placebo group (for mean differences between changes of the magnesium and the placebo groups). Magnesium 83-92 apolipoprotein B Homo sapiens 60-76 2719498-4 1989 We found a 13% increase in molar ratio of apolipoprotein A1:apolipoprotein B after magnesium treatment, as compared with a 2% increase in the placebo group (for mean differences between changes of the magnesium and the placebo groups). Magnesium 201-210 apolipoprotein A1 Homo sapiens 42-59 2719498-5 1989 This increase was caused by a decrease in apolipoprotein B concentrations, which were reduced by 15% from 1.44 to 1.23 mmol/L in the magnesium group as compared with a slight increase in the placebo group. Magnesium 133-142 apolipoprotein B Homo sapiens 42-58 2715183-0 1989 The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen. Magnesium 62-66 integrin subunit alpha 2 Homo sapiens 34-39 2725017-4 1989 Calcium-free, 10 mM magnesium artificial cerebrospinal fluid (ACSF) was shown to protect CA1 pyramidal cells against anoxic damage. Magnesium 20-29 carbonic anhydrase 1 Rattus norvegicus 89-92 2785592-5 1989 Plasma osteocalcin values correlated with plasma magnesium levels (r = 0.54; p less than 0.05). Magnesium 49-58 bone gamma-carboxyglutamate protein Homo sapiens 7-18 2785592-6 1989 Oral magnesium supplements normalized plasma magnesium, calcium, and osteocalcin levels, all of which were normal at the postchemotherapy study. Magnesium 5-14 bone gamma-carboxyglutamate protein Homo sapiens 69-80 2519816-6 1989 A negative correlation between plasma Mg and plasma PTH concentration was obtained in uremic patients. Magnesium 38-40 parathyroid hormone Homo sapiens 52-55 2629314-2 1989 The effect of plasma alkalization with sodium bicarbonate on possible changes of magnesium concentration in the CSF was studied. Magnesium 81-90 colony stimulating factor 2 Homo sapiens 112-115 2629314-3 1989 It was found that in healthy subjects magnesium concentration of the CSF was higher than in plasma, and was increased further in chronic uraemia. Magnesium 38-47 colony stimulating factor 2 Homo sapiens 69-72 2629314-4 1989 Plasma alkalization in uraemia with sodium bicarbonate reduced the concentration of magnesium in the CSF. Magnesium 84-93 colony stimulating factor 2 Homo sapiens 101-104 2702751-6 1989 ALP requires Mg ion in vitro for optimal activity, but addition of Mg in the appropriate amounts to sera with low ALP activity did not restore ALP activity. Magnesium 13-15 alkaline phosphatase, placental Homo sapiens 0-3 2702751-6 1989 ALP requires Mg ion in vitro for optimal activity, but addition of Mg in the appropriate amounts to sera with low ALP activity did not restore ALP activity. Magnesium 67-69 alkaline phosphatase, placental Homo sapiens 114-117 2702751-6 1989 ALP requires Mg ion in vitro for optimal activity, but addition of Mg in the appropriate amounts to sera with low ALP activity did not restore ALP activity. Magnesium 67-69 alkaline phosphatase, placental Homo sapiens 114-117 2651054-0 1989 Improved insulin response and action by chronic magnesium administration in aged NIDDM subjects. Magnesium 48-57 insulin Homo sapiens 9-16 2547951-4 1989 Serum magnesium was, however, positively correlated to plasma renin activity (PRA) (r = 0.38, P less than 0.05) while both 24 h urinary excretion of calcium and cAMP were found to be correlated to both PRA and urinary aldosterone in a positive way (r = 0.39-0.42, P less than 0.01 and r = 0.33-0.57, P less than 0.01, respectively). Magnesium 6-15 renin Homo sapiens 62-67 2534969-8 1989 Nasal insufflation of 1-desamino-8-D-arginine-vasopressin induced both an increase in potassium excretion and a decrease in calcium and magnesium excretion. Magnesium 136-145 arginine vasopressin Homo sapiens 46-57 2565567-1 1989 Reduction of external calcium and magnesium from 1.5 to 1.2 mM intensified potassium-induced interictal bursts, increased the likelihood of electrographic seizure occurrence in CA1, and rendered seizure initiation independent of N-methyl-D-aspartate (NMDA) receptor activation. Magnesium 34-43 carbonic anhydrase 1 Homo sapiens 177-180 2729592-2 1989 The selectivity of Mg2+ over Na+, K+, H+, and Ca2+ is sufficient for assays of intracellular magnesium ion activities. Magnesium 93-102 carbonic anhydrase 2 Homo sapiens 46-49 2538363-4 1989 It is suggested that the conformation of cytochrome c oxidase may be regulated by the tightly bound "non-redox" metal ions (Mg, Zn, Cux) known to be present in the enzyme. Magnesium 124-126 cut like homeobox 1 Homo sapiens 132-135 2920177-0 1989 Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy. Magnesium 19-28 hexokinase 1 Homo sapiens 63-74 2461098-10 1988 It is concluded that lithium directly inhibits the activation of vasopressin-sensitive adenylate cyclase in renal epithelia by competing with magnesium for activation of Gs. Magnesium 142-151 arginine vasopressin Homo sapiens 65-76 2545861-9 1989 The mechanism of this effect is probably related to the capability of Ca++ and Mg++ to enhance the maximum number of [3H]PAF binding sites in whole or lysed PMNs without affecting the affinity (Kd) of the ligand. Magnesium 79-83 PCNA clamp associated factor Homo sapiens 121-124 2644285-7 1989 The availability of large amounts of bacterially produced oncomodulin combined with the ability to modify at will the metal-binding ligands should now allow dissection of the unusual pairing in oncomodulin of one calcium-specific calmodulin-like site with one calcium/magnesium parvalbumin-like site. Magnesium 268-277 oncomodulin Rattus norvegicus 58-69 2920045-0 1989 Magnesium-dependent non-specific binding of [125I]prolactin to myelinated tracts in the rat central nervous system. Magnesium 0-9 prolactin Rattus norvegicus 50-59 2920045-1 1989 An in vitro autoradiographic assay was used in identifying a magnesium-dependent, non-specific binding of [125I] prolactin to myelinated fiber tracts in the rat brain. Magnesium 61-70 prolactin Rattus norvegicus 113-122 2920045-3 1989 Magnesium in the incubation medium caused a non-specific binding of radiolabelled prolactin to the myelinated fiber tracts in the brain. Magnesium 0-9 prolactin Rattus norvegicus 82-91 2553554-4 1989 These results suggested that a control mechanism for MAO activity during pregnancy might exist due to an increase in catecholamine and that the beta 2-effect of ritodrine induced a lowering in serum calcium and magnesium levels. Magnesium 211-220 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 144-150 2473355-1 1989 In initial studies of human atrial natriuretic factor (ANF) administered to man, 100 microns intravenous bolus doses infused in normal volunteers and patients with essential hypertension resulted in clear increases in urinary excretion of sodium (four- to sixfold), urine volume, calcium, magnesium, and phosphorous. Magnesium 289-298 natriuretic peptide A Homo sapiens 55-58 2918302-4 1989 Both calcium and magnesium were found to activate NAT by a similar mechanism, with calcium being more effective than magnesium. Magnesium 17-26 N-acetyltransferase 1 Rattus norvegicus 50-53 2918302-4 1989 Both calcium and magnesium were found to activate NAT by a similar mechanism, with calcium being more effective than magnesium. Magnesium 117-126 N-acetyltransferase 1 Rattus norvegicus 50-53 2927254-0 1989 Magnesium potentiation of iron-transferrin binding. Magnesium 0-9 transferrin Homo sapiens 31-42 2927254-2 1989 When magnesium was added, a marked increase occurred in both the rate of iron binding and the maximum level of iron loaded on transferrin utilizing either iron salt. Magnesium 5-14 transferrin Homo sapiens 126-137 2927254-4 1989 These data suggest an allosteric effect on transferrin by magnesium which potentiates iron (III) binding. Magnesium 58-67 transferrin Homo sapiens 43-54 2515398-6 1989 Mg loading blunted the rise in BP and the aldosterone-stimulating effect of AII, whereas Mg depletion significantly enhanced these AII effects. Magnesium 0-2 angiotensinogen Homo sapiens 76-79 2515398-7 1989 These results support the hypothesis that Mg may be an antagonist of the pressor and steroidogenic effects of AII. Magnesium 42-44 angiotensinogen Homo sapiens 110-113 2538718-4 1989 However, in the presence of magnesium ions PAP required the addition of a cleavage and polyadenylation factor to specifically polyadenylate pre-mRNAs that contain an intact AAUAAA sequence and end at the poly(A) addition site (precleaved RNA substrates). Magnesium 28-37 poly(A) polymerase alpha Homo sapiens 43-46 2974246-1 1988 Atrial natriuretic peptide (ANP) infusion increases fractional excretion of many solutes including sodium, chloride, bicarbonate, phosphate, calcium, and magnesium. Magnesium 154-163 natriuretic peptide A Rattus norvegicus 0-26 2974246-1 1988 Atrial natriuretic peptide (ANP) infusion increases fractional excretion of many solutes including sodium, chloride, bicarbonate, phosphate, calcium, and magnesium. Magnesium 154-163 natriuretic peptide A Rattus norvegicus 28-31 3071486-0 1988 Impaired insulin-induced erythrocyte magnesium accumulation is correlated to impaired insulin-mediated glucose disposal in type 2 (non-insulin-dependent) diabetic patients. Magnesium 37-46 insulin Homo sapiens 9-16 3071486-0 1988 Impaired insulin-induced erythrocyte magnesium accumulation is correlated to impaired insulin-mediated glucose disposal in type 2 (non-insulin-dependent) diabetic patients. Magnesium 37-46 insulin Homo sapiens 86-93 3071486-3 1988 In vitro incubation in the presence of 100 mU/l insulin significantly increased magnesium erythrocyte levels in both control subjects (p less than 0.001) and patients with diabetes (p less than 0.001). Magnesium 80-89 insulin Homo sapiens 48-55 3071486-4 1988 However, even in the presence of 100 mU/l insulin, the erythrocyte magnesium content of patients with Type 2 diabetes was lower than that of control subjects. Magnesium 67-76 insulin Homo sapiens 42-49 3071486-6 1988 Such reduction of the maximal effect of insulin suggests that the impairment of insulin-induced erythrocyte magnesium accumulation observed in Type 2 diabetic patients results essentially from a post-receptor defect. Magnesium 108-117 insulin Homo sapiens 40-47 3071486-6 1988 Such reduction of the maximal effect of insulin suggests that the impairment of insulin-induced erythrocyte magnesium accumulation observed in Type 2 diabetic patients results essentially from a post-receptor defect. Magnesium 108-117 insulin Homo sapiens 80-87 3241201-0 1988 Intracellular free magnesium in hypertension: relation to peripheral insulin resistance. Magnesium 19-28 insulin Homo sapiens 69-76 3241201-5 1988 Thus, suppressed intracellular Mg is linked to hypertension and to decreased tissue insulin sensitivity, and is not consequent to the hyperinsulinaemia itself. Magnesium 31-33 insulin Homo sapiens 84-91 3079422-1 1988 High concentrations of extracellular Mg in the rat and sheep but not in man stimulate renin secretion. Magnesium 37-39 renin Homo sapiens 86-91 16666489-1 1988 Phosphoenolpyruvate carboxylase isolated from maize (Zea mays L.) leaves was assayed with varying concentrations of free phosphoenolpyruvate at several fixed-varying concentrations of free magnesium higher than required to saturate the enzyme reaction. Magnesium 189-198 MLO-like protein 4 Zea mays 0-31 2972721-1 1988 We have investigated here the pre-steady state kinetics of sarcoplasmic reticulum ATPase incubated under conditions where significant amounts of Mg.ATP and Ca.ATP coexist, both of them being substrates for the ATPase. Magnesium 145-147 dynein axonemal heavy chain 8 Homo sapiens 82-88 2972721-1 1988 We have investigated here the pre-steady state kinetics of sarcoplasmic reticulum ATPase incubated under conditions where significant amounts of Mg.ATP and Ca.ATP coexist, both of them being substrates for the ATPase. Magnesium 145-147 dynein axonemal heavy chain 8 Homo sapiens 210-216 2574205-3 1989 Lymphocyte killing of the anti-Fc gamma RIII bearing HC (HC 3G8) was Ca++ dependent, but Mg++ independent. Magnesium 89-93 Fc gamma receptor IIIa Homo sapiens 31-44 2574205-5 1989 In addition, freshly prepared monocytes were able to kill HC 3G8 in a Mg++-dependent, Ca++-independent fashion, indicating that low levels of Fc gamma RIII may be functionally detected on monocytes. Magnesium 70-74 Fc gamma receptor IIIa Homo sapiens 142-155 2547206-1 1989 Radioligand binding studies have previously identified a high affinity, magnesium-dependent, guanine nucleotide-sensitive binding site for corticotropin-releasing factor (CRF) in mouse spleen. Magnesium 72-81 corticotropin releasing hormone Mus musculus 139-169 2644845-1 1989 The mammalian renal thick ascending limb of Henle (TAL) reabsorbs approximately 55% of the filtered magnesium; accordingly, it is the major segment involved in control of renal Mg balance. Magnesium 100-109 transaldolase 1 Homo sapiens 51-54 2644845-1 1989 The mammalian renal thick ascending limb of Henle (TAL) reabsorbs approximately 55% of the filtered magnesium; accordingly, it is the major segment involved in control of renal Mg balance. Magnesium 177-179 transaldolase 1 Homo sapiens 51-54 2644845-2 1989 This review discusses recent evidence for passive and active transport of Mg through the paracellular and transcellular pathways of the TAL, respectively. Magnesium 74-76 transaldolase 1 Homo sapiens 136-139 2644845-6 1989 Magnesium reabsorption in the TAL is also closely associated with NaCl absorption so that factors that influence NaCl also affect magnesium. Magnesium 0-9 transaldolase 1 Homo sapiens 30-33 2644845-6 1989 Magnesium reabsorption in the TAL is also closely associated with NaCl absorption so that factors that influence NaCl also affect magnesium. Magnesium 130-139 transaldolase 1 Homo sapiens 30-33 2644845-7 1989 Magnesium deficiency results in a specific and apparently intrinsic cellular adaptation to increase Mg absorption in the TAL. Magnesium 0-9 transaldolase 1 Homo sapiens 121-124 2644845-7 1989 Magnesium deficiency results in a specific and apparently intrinsic cellular adaptation to increase Mg absorption in the TAL. Magnesium 100-102 transaldolase 1 Homo sapiens 121-124 2644845-9 1989 Parathyroid hormone, calcitonin, glucagon, and antidiuretic hormone act through a common second messenger, adenosine 3",5"-cyclic monophosphate, to limit Mg excretion by enhancing active Mg transport in the TAL. Magnesium 154-156 parathyroid hormone Homo sapiens 0-19 2644845-9 1989 Parathyroid hormone, calcitonin, glucagon, and antidiuretic hormone act through a common second messenger, adenosine 3",5"-cyclic monophosphate, to limit Mg excretion by enhancing active Mg transport in the TAL. Magnesium 154-156 transaldolase 1 Homo sapiens 207-210 2644845-11 1989 Clearly, recent observations, using in vivo and in vitro microperfusion studies, have altered our thinking of TAL function and indicate that Mg transport is sensitively and specifically controlled within this segment. Magnesium 141-143 transaldolase 1 Homo sapiens 110-113 2540806-3 1989 In the absence of insulin, a noncovalent association of the alpha beta heterodimeric insulin receptor complex into an alpha 2 beta 2 heterotetrameric state required the continuous presence of both a divalent metal ion (Mn or Mg) and an adenine nucleotide (ATP, ADP, or AMPPCP). Magnesium 225-227 insulin Homo sapiens 85-92 2563332-1 1989 The present experiments describe a long-lasting form of potentiation induced in field CA1 of rat hippocampal slices by bath application of N-methyl-D-aspartate (NMDA), in association with low magnesium concentrations, glycine and spermine. Magnesium 192-201 carbonic anhydrase 1 Rattus norvegicus 86-89 2678848-7 1989 Magnesium deficiency can predispose to increased contractility of the arteries and its excess can modulate smooth muscle contractility caused by bradykinin, angiotensin II, serotonin, prostaglandins and catecholamines. Magnesium 0-9 kininogen 1 Homo sapiens 145-155 2678848-7 1989 Magnesium deficiency can predispose to increased contractility of the arteries and its excess can modulate smooth muscle contractility caused by bradykinin, angiotensin II, serotonin, prostaglandins and catecholamines. Magnesium 0-9 angiotensinogen Homo sapiens 157-171 2474264-6 1989 The possible immuno-protective role of alpha-FP in maternal and fetal MG evolution is discussed. Magnesium 70-72 alpha fetoprotein Homo sapiens 39-47 2702039-4 1989 In calcium- and magnesium-free Hanks" balanced salt solution, TGF-beta in the internal aqueous compartment was stable for at least five days, even in the presence of trypsin and ethylenediamine tetraacetic acid. Magnesium 16-25 transforming growth factor beta 1 Homo sapiens 62-70 2670220-2 1989 In patients with chronic heart failure, angiotensin-converting enzyme (ACE) inhibitors, such as captopril, enalapril, and quinapril, have been shown to improve hemodynamics, reduce symptoms of fatigue and dyspnea, increase exercise capacity, correct hyponatremia, reduce diuretic requirements and ventricular arrhythmias, and conserve potassium and magnesium. Magnesium 349-358 angiotensin I converting enzyme Homo sapiens 40-69 2670220-2 1989 In patients with chronic heart failure, angiotensin-converting enzyme (ACE) inhibitors, such as captopril, enalapril, and quinapril, have been shown to improve hemodynamics, reduce symptoms of fatigue and dyspnea, increase exercise capacity, correct hyponatremia, reduce diuretic requirements and ventricular arrhythmias, and conserve potassium and magnesium. Magnesium 349-358 angiotensin I converting enzyme Homo sapiens 71-74 2706797-5 1989 The inhibitory effect of magnesium on thrombin-induced serotonin release, less important in platelets from SHR than in control ones, seems to pass through two phenomena: an inhibition of calcium influx occurring at high concentrations and less effective on SHR platelets and a stimulation of calcium influx, probably corresponding to intracellular calcium sequestering, observed in the presence of low magnesium concentrations and enhanced in platelets from SHR. Magnesium 25-34 coagulation factor II Rattus norvegicus 38-46 2706797-5 1989 The inhibitory effect of magnesium on thrombin-induced serotonin release, less important in platelets from SHR than in control ones, seems to pass through two phenomena: an inhibition of calcium influx occurring at high concentrations and less effective on SHR platelets and a stimulation of calcium influx, probably corresponding to intracellular calcium sequestering, observed in the presence of low magnesium concentrations and enhanced in platelets from SHR. Magnesium 402-411 coagulation factor II Rattus norvegicus 38-46 2706797-6 1989 This study therefore evidence a relationship between the increases observed in both serotonin secretion and calcium influx on thrombin-stimulated SHR platelets and suggests cellular mechanisms involved in the inhibitory action of magnesium impaired in these SHR platelets. Magnesium 230-239 coagulation factor II Rattus norvegicus 126-134 2646553-0 1989 Endogenous and network bursts induced by N-methyl-D-aspartate and magnesium free medium in the CA3 region of the hippocampal slice. Magnesium 66-75 carbonic anhydrase 3 Rattus norvegicus 95-98 2646553-5 1989 In the presence of N-methyl-D-aspartate or magnesium-free medium, population bursts were synchronized by activating single CA3 neurons. Magnesium 43-52 carbonic anhydrase 3 Rattus norvegicus 123-126 2530698-1 1989 Changes in a bioenergetic state of Trichinella spiralis and Trichinella pseudospiralis infected rat and mouse muscle mitochondria were evaluated enzymatically, and in both infections 3-4-fold increase of mitochondrial, Mg++-stimulated ATP-ase (EC 3.6.1.3) was observed. Magnesium 219-223 dynein, axonemal, heavy chain 8 Mus musculus 235-242 3246777-3 1988 Assuming that magnesium (Mg) might participate in the alteration of Ca and PTH levels, the postoperative changes in intracytoplasmic Mg levels of erythrocyte were determined for several days. Magnesium 14-23 parathyroid hormone Homo sapiens 75-78 3196924-1 1988 The potency of adenosine in reducing orthodromically evoked population potentials elicited in area CA1 of rat hippocampal slices was greatly reduced by removal of magnesium from the bathing medium. Magnesium 163-172 carbonic anhydrase 1 Rattus norvegicus 99-102 2978286-10 1988 ANF, but not saline, enhanced urinary excretion of calcium and magnesium. Magnesium 63-72 natriuretic peptide A Homo sapiens 0-3 3246777-3 1988 Assuming that magnesium (Mg) might participate in the alteration of Ca and PTH levels, the postoperative changes in intracytoplasmic Mg levels of erythrocyte were determined for several days. Magnesium 25-27 parathyroid hormone Homo sapiens 75-78 2973849-5 1988 hANP increased urine flow rate, sodium, calcium and magnesium excretion without significant changes in potassium and phosphate excretion, heart rate or blood pressure. Magnesium 52-61 natriuretic peptide A Homo sapiens 0-4 3178843-1 1988 In contrast to the reactivity of geranyl methylene-diphosphonate in the reaction catalyzed by farnesyl diphosphate synthase, that of isopentenyl methylenediphosphonate showed an optimum at a more acidic pH than that of isopentenyl diphosphate, and it was inhibited by magnesium ions under certain conditions. Magnesium 268-277 farnesyl diphosphate synthase Homo sapiens 94-123 3201396-8 1988 Magnesium (1 mM) showed greatly reduced effects on factor Xa activity relative to activities with calcium. Magnesium 0-9 coagulation factor X Homo sapiens 51-60 3198135-6 1988 Ca++ and Mg++, in 0.1 and 0.5 mM concentrations, respectively, helped to prevent large-scale SP2/0 lysis following pulse application. Magnesium 9-13 Sp2 transcription factor Mus musculus 93-98 3146405-0 1988 Treatment with the thyrotropin-releasing hormone analog CG3703 restores magnesium homeostasis following traumatic brain injury in rats. Magnesium 72-81 thyrotropin releasing hormone Rattus norvegicus 19-48 3146405-2 1988 Previous studies have shown that traumatic brain injury is associated with a profound decline in intracellular free magnesium (Mgf) and in total tissue magnesium (Mgt), the extent of Mgf decline being linearly correlated to the severity of injury and resultant neurological deficit. Magnesium 116-125 KIT ligand Rattus norvegicus 127-130 3414685-8 1988 The mean phosphate/alpha-MG uptake ratio in Hyp cultures was 82% of that in normal cells (P less than 0.01, n = 96). Magnesium 25-27 phosphate regulating endopeptidase homolog, X-linked Mus musculus 44-47 3197698-4 1988 In these slices, we have found that, in the magnesium-free (0-Mg2+) model, there is good electrical communication between area CA3 and the EC. Magnesium 44-53 carbonic anhydrase 3 Homo sapiens 127-130 2853143-5 1988 The intrinsic fluorescence of the enzyme in E1 and E2 conformations is modified suggesting the occurrence of ascorbate-induced intermediate forms, distinct from those provoked by the addition of cations, magnesium and phosphate. Magnesium 204-213 E1 small nucleolar RNA Oryctolagus cuniculus 44-53 2850363-0 1988 Different sensitivity of ATP + Mg + Na (I) and Pi + Mg (II) dependent types of ouabain binding to phospholipase A2. Magnesium 31-33 phospholipase A2 group IB Rattus norvegicus 98-114 2850363-0 1988 Different sensitivity of ATP + Mg + Na (I) and Pi + Mg (II) dependent types of ouabain binding to phospholipase A2. Magnesium 52-54 phospholipase A2 group IB Rattus norvegicus 98-114 2850363-2 1988 It was found that phospholipase A2 (PLA2) may distinguish or dissociate ouabain binding complexes I (ATP + Mg + Na) and II (Pi + Mg), stimulating the former and inhibiting the latter. Magnesium 107-109 phospholipase A2 group IB Rattus norvegicus 18-34 2850363-2 1988 It was found that phospholipase A2 (PLA2) may distinguish or dissociate ouabain binding complexes I (ATP + Mg + Na) and II (Pi + Mg), stimulating the former and inhibiting the latter. Magnesium 107-109 phospholipase A2 group IB Rattus norvegicus 36-40 2850363-2 1988 It was found that phospholipase A2 (PLA2) may distinguish or dissociate ouabain binding complexes I (ATP + Mg + Na) and II (Pi + Mg), stimulating the former and inhibiting the latter. Magnesium 129-131 phospholipase A2 group IB Rattus norvegicus 18-34 2850363-2 1988 It was found that phospholipase A2 (PLA2) may distinguish or dissociate ouabain binding complexes I (ATP + Mg + Na) and II (Pi + Mg), stimulating the former and inhibiting the latter. Magnesium 129-131 phospholipase A2 group IB Rattus norvegicus 36-40 3167583-5 1988 The excitatory effect of vasopressin was postsynaptic, since it was not abolished following synaptic blockade in a low calcium-high magnesium perifusion solution. Magnesium 132-141 arginine vasopressin Rattus norvegicus 25-36 2971394-8 1988 Magnesium is required for both ATPase activity and microtubule gelation-contraction. Magnesium 0-9 dynein axonemal heavy chain 8 Homo sapiens 31-37 3066645-13 1988 In addition, Mg ion was found to play an important role in the biosynthesis of renin and steroid hormones but to have no such significant role in the urinary excretions of kinin, PGE2, and 6-keto-PGF1 alpha. Magnesium 13-15 renin Rattus norvegicus 79-84 3407685-0 1988 Effect of magnesium on plasma cholinesterase activity. Magnesium 10-19 butyrylcholinesterase Homo sapiens 30-44 2484545-8 1988 The results demonstrate: (1) the relationship and interdependence of Fe, Cu, and Zn concentrations in modulating the growth of normal lymphocytes; (2) the stimulatory effects of Fe on B cells and Zn on CD8 positive cells; (3) the inhibitory effect of Cu at concentrations lower than those of Fe and Zn; (4) the requirement of Ca and Mg in certain concentration and ratio for the action of the other cations; and (5) the Ca and Mg requirement for the growth of B cells higher than T cells. Magnesium 333-335 CD8a molecule Homo sapiens 202-205 2484545-8 1988 The results demonstrate: (1) the relationship and interdependence of Fe, Cu, and Zn concentrations in modulating the growth of normal lymphocytes; (2) the stimulatory effects of Fe on B cells and Zn on CD8 positive cells; (3) the inhibitory effect of Cu at concentrations lower than those of Fe and Zn; (4) the requirement of Ca and Mg in certain concentration and ratio for the action of the other cations; and (5) the Ca and Mg requirement for the growth of B cells higher than T cells. Magnesium 427-429 CD8a molecule Homo sapiens 202-205 3197694-2 1988 When magnesium is eliminated from the medium bathing the hippocampal slice, spontaneously occurring electrical events which closely resemble electrographic seizures can be recorded extracellularly from area CA3. Magnesium 5-14 carbonic anhydrase 3 Homo sapiens 207-210 2843781-2 1988 The GP1 and GC1 receptors are negatively modulated by magnesium and noncompetitively inhibited by phencyclidine; GP2 and GC2 receptors are insensitive to inhibition by magnesium and phencyclidine (Costa, Fadda, Kozikowski, Nicoletti and Wroblewski, 1988). Magnesium 54-63 GTP binding protein 1 Homo sapiens 4-7 24248801-5 1988 However, statistical analysis showed a significant variation between the different districts for T.H., Cu, Mg and chloride for both tap and stored waters. Magnesium 107-109 nuclear RNA export factor 1 Homo sapiens 132-135 3260620-9 1988 We conclude: (1) IL-2 induces an increase in vascular permeability causing the development of edema, sodium avidity, and prerenal azotemia as occurs during endotoxemia; (2) IL-2 therapy induces respiratory alkalosis with the subsequent intracellular shift of phosphorous accompanied by increased renal phosphorous reabsorption; and (3) there is no evidence of renal tubular dysfunction (renal tubular acidosis [RTA], renal leak of glucose, phosphorous, or magnesium). Magnesium 456-465 interleukin 2 Homo sapiens 17-21 3260620-9 1988 We conclude: (1) IL-2 induces an increase in vascular permeability causing the development of edema, sodium avidity, and prerenal azotemia as occurs during endotoxemia; (2) IL-2 therapy induces respiratory alkalosis with the subsequent intracellular shift of phosphorous accompanied by increased renal phosphorous reabsorption; and (3) there is no evidence of renal tubular dysfunction (renal tubular acidosis [RTA], renal leak of glucose, phosphorous, or magnesium). Magnesium 456-465 interleukin 2 Homo sapiens 173-177 3226954-4 1988 Fluoresceine coupled in position 1 of oxytocin gave an analog of low to moderate uterine (3.8 without Mg+ and 1.9 with Mg++) and milk ejection (7.9) activities. Magnesium 102-105 oxytocin/neurophysin I prepropeptide Homo sapiens 38-46 3226954-4 1988 Fluoresceine coupled in position 1 of oxytocin gave an analog of low to moderate uterine (3.8 without Mg+ and 1.9 with Mg++) and milk ejection (7.9) activities. Magnesium 119-123 oxytocin/neurophysin I prepropeptide Homo sapiens 38-46 2843781-2 1988 The GP1 and GC1 receptors are negatively modulated by magnesium and noncompetitively inhibited by phencyclidine; GP2 and GC2 receptors are insensitive to inhibition by magnesium and phencyclidine (Costa, Fadda, Kozikowski, Nicoletti and Wroblewski, 1988). Magnesium 54-63 solute carrier family 25 member 22 Homo sapiens 12-15 3167108-0 1988 [The effect of calcium and magnesium ions on the interaction of calcium-binding proteins parvalbumin and alpha-lactalbumin with dipalmitoylphosphatidylcholine vesicles]. Magnesium 27-36 parvalbumin Homo sapiens 89-100 16666161-0 1988 Role of Magnesium in the Binding of Substrate and Effectors to Phosphoenolpyruvate Carboxylase from a CAM Plant. Magnesium 8-17 phosphoenolpyruvate carboxykinase 1 Homo sapiens 63-94 2901760-3 1988 We show here that the intervening sequence can promote its own excision in the presence of high concentrations of magnesium ion (50 mM), but that at physiological concentrations of the divalent cation (5 mM), the splicing reaction requires the presence of the CBP2-encoded product. Magnesium 114-123 Cbp2p Saccharomyces cerevisiae S288C 260-264 3167108-0 1988 [The effect of calcium and magnesium ions on the interaction of calcium-binding proteins parvalbumin and alpha-lactalbumin with dipalmitoylphosphatidylcholine vesicles]. Magnesium 27-36 lactalbumin alpha Homo sapiens 105-122 3385207-2 1988 This study was undertaken to determine the hypotensive effect of magnesium administration in relation to the state of activation of the renin-angiotensin system. Magnesium 65-74 renin Rattus norvegicus 136-141 3359576-6 1988 The ventricular binding of 125I-angiotensin II was stimulated approximately twofold in the presence of the divalent cations calcium and magnesium (10 mM). Magnesium 136-145 angiotensinogen Homo sapiens 32-46 2966770-4 1988 Human ANF-(99-126) infusion for 45 minutes at 0.034 microgram/kg/min augmented (p less than 0.05-0.01) diuresis and urinary sodium, chloride, calcium, phosphate, and magnesium excretion. Magnesium 166-175 natriuretic peptide A Homo sapiens 6-9 3413301-3 1988 It is likely that the shortage of magnesium in serum makes a suppression of PTH secretion. Magnesium 34-43 parathyroid hormone Homo sapiens 76-79 2836849-4 1988 Magnesium metabolism is accurately controlled, in particular by parathyroid hormone, 25 - dihydroxy vitamin D3, calcitonin, catecholamine and estrogens. Magnesium 0-9 parathyroid hormone Homo sapiens 64-83 3411442-3 1988 When rabbit platelets were activated by thrombin which induces maximum response, approximately 80% of the platelet serotonin and calcium, but only 50% of platelet magnesium were released. Magnesium 163-172 prothrombin Oryctolagus cuniculus 40-48 3411442-5 1988 In response to a lower concentration of thrombin, calcium and magnesium were released to a greater extent than was serotonin. Magnesium 62-71 coagulation factor II, thrombin Homo sapiens 40-48 3385207-7 1988 We conclude that the blood pressure lowering effect of Mg is related, in part, to the state of activation of the renin-angiotensin system. Magnesium 55-57 renin Rattus norvegicus 113-118 3198695-1 1988 Increasing the intracellular magnesium concentration of PtK2 cells by 1 mM or more resulted in the disassembly of the interphase microtubule array over a period of 5 min after microinjection. Magnesium 29-38 protein tyrosine kinase 2 Homo sapiens 56-60 3257726-3 1988 Upon vasopressin discontinuation, ECG findings returned to normal before magnesium supplementation. Magnesium 73-82 arginine vasopressin Homo sapiens 5-16 3396512-3 1988 It is suggested that the serum magnesium concentration might play an important role in urinary phosphate excretion, probably in relation to the parathyroid hormone function. Magnesium 31-40 parathyroid hormone Homo sapiens 144-163 3276849-5 1988 Dietary Mg concentration should be in the range 1.5-2.5 g/kg OMD. Magnesium 8-10 osteomodulin Homo sapiens 61-64 3335547-3 1988 In the presence of increasing amounts of calcium or magnesium ions, lyophilized powders of (Z)-L-Gla-OMe exhibit a corresponding increase in thermal stability. Magnesium 52-61 galactosidase alpha Homo sapiens 97-100 3335547-6 1988 Under these conditions, complex formation with Mg(II) apparently favors a 2:1 Gla-magnesium ion complex in which both Gla residues are unstable to thermal decarboxylation. Magnesium 82-91 galactosidase alpha Homo sapiens 78-81 3335547-4 1988 Both magnesium and calcium form relatively tight, thermally stable complexes with (Z)-L-Gla-OMe at high metal ion concentrations. Magnesium 5-14 galactosidase alpha Homo sapiens 88-91 3335547-6 1988 Under these conditions, complex formation with Mg(II) apparently favors a 2:1 Gla-magnesium ion complex in which both Gla residues are unstable to thermal decarboxylation. Magnesium 82-91 galactosidase alpha Homo sapiens 118-121 3179576-0 1988 Acute effects of human growth hormone on zinc, copper, calcium and magnesium metabolism in normal subjects. Magnesium 67-76 growth hormone 1 Homo sapiens 23-37 3353389-1 1988 Previous studies from this laboratory have demonstrated that vasopressin stimulates K, Mg, Ca, Cl, and Na reabsorption by the thick ascending limb of Henle"s loop (TALH) of the rat kidney. Magnesium 87-89 arginine vasopressin Rattus norvegicus 61-72 3277491-4 1988 Specific abnormalities in calcium and magnesium metabolism which are related to deviations in the renin system have been identified. Magnesium 38-47 renin Homo sapiens 98-103 3179576-1 1988 The acute effects of human growth hormone (hGH) on the metabolism of zinc, copper, calcium and magnesium ions was studied. Magnesium 95-104 growth hormone 1 Homo sapiens 27-41 3338152-0 1988 Stimulating effects of calcium and magnesium on serum pseudocholinesterase activity. Magnesium 35-44 butyrylcholinesterase Homo sapiens 54-74 3075149-3 1988 Insulin without affecting the filtration rate of creatinine and the urine flow rate resulted in significant increases in urinary calcium (3.56 +/- 0.80 vs. 7.48 +/- 0.80 mumol/min/1.73 m2) and magnesium (2.44 +/- 0.41 vs. 4.29 +/- 0.5 mumol/min/1.73 m2) and a fall in potassium excretion (53.25 +/- 13.17 vs. 23.71 +/- 4.21 mumol/min/1.73 m2). Magnesium 193-202 insulin Homo sapiens 0-7 3276524-3 1988 It is based on the PTS-catalysed formation of tetrahydrobiopterin from dihydroneopterin triphosphate in the presence of magnesium, sepiapterin reductase, NADPH, dihydropteridine reductase, and NADH, and fluorimetric measurement of the product as biopterin by high performance liquid chromatography (HPLC) after oxidation with iodine. Magnesium 120-129 6-pyruvoyltetrahydropterin synthase Homo sapiens 19-22 3208481-9 1988 This in turn leads to a chronic depletion of magnesium in hypertensives who have high levels of plasma renin activity and highly elevated plasma aldosterone. Magnesium 45-54 renin Homo sapiens 103-108 3325393-4 1987 Recently, controlled studies have shown that the introduction and supplementation of therapeutic regimens with ACE inhibitions and specifically captopril is associated with substantial clinical benefits: Symptoms are reduced as hemodynamics and exercise capacity improve, metabolic derangements (including fluid retention, potassium and magnesium loss and sympathetic nervous activation) are reduced with resultant favourable effects on arrhythmia frequency and finally the newest and most dramatic observation of improved survival. Magnesium 337-346 angiotensin I converting enzyme Homo sapiens 111-114 3169195-4 1988 Bath application of noradrenaline, isoproterenol and histamine or a transient exposure to Mg++-free medium caused a long lasting increase in extracellularly recorded population spikes induced in CA1 by electrical stimulation of stratum radiatum. Magnesium 90-94 carbonic anhydrase 1 Mus musculus 195-198 3054347-0 1988 Oral administration of magnesium hydroxide to subjects with insulin-dependent diabetes mellitus: effects on magnesium and potassium levels and on insulin requirements. Magnesium 23-32 insulin Homo sapiens 60-67 3327518-7 1987 Furthermore, magnesium selectively inhibited endonuclease III activity when AP DNA was used as a substrate but had no effect when DNA containing either urea or thymine glycol was used as substrate. Magnesium 13-22 endonuclease III Escherichia coli 45-61 3680484-3 1987 Although Mg infusion increased her serum Mg levels and enhanced renal PTH action, as evidenced by an elevation in nephrogenous cAMP, the serum 1,25-(OH)2D level remained low. Magnesium 9-11 parathyroid hormone Homo sapiens 70-73 2824473-12 1987 Inositol polyphosphate 1-phosphatase shows a sigmoidal dependence upon magnesium ion, with 0.3 mM Mg2+ causing half-maximal stimulation. Magnesium 71-80 inositol polyphosphate-1-phosphatase Bos taurus 0-36 3693404-6 1987 The phosphorylated myosin could be induced to form filaments by lowering the pH or by increasing the magnesium concentration to 10 mM. Magnesium 101-110 myosin heavy chain 14 Homo sapiens 19-25 3446017-2 1987 All 3 enzymes are active under high salt conditions in the presence of high magnesium concentration. Magnesium 76-85 paired box 5 Homo sapiens 0-5 2960795-7 1987 Reducing the ambient magnesium ion from 1.2 mM to zero increased the EC50 values for all vasopressin agonists by 6- to 20-fold, but had no effect on maximal response size, nor on the concentration-response curve for norepinephrine. Magnesium 21-30 arginine vasopressin Rattus norvegicus 89-100 3680216-0 1987 Subcellular calcium and magnesium mobilization in rat liver stimulated in vivo with vasopressin and glucagon. Magnesium 24-33 arginine vasopressin Rattus norvegicus 84-95 3315399-0 1987 Impaired insulin-mediated erythrocyte magnesium accumulation in essential hypertension. Magnesium 38-47 insulin Homo sapiens 9-16 3315399-2 1987 This study was designed to investigate variations in erythrocyte magnesium in the presence of insulin (0.1 unit/l) in hypertensive subjects. Magnesium 65-74 insulin Homo sapiens 94-101 3451413-2 1987 In all diabetics taken as a whole and in insulin dependent and non-insulin dependent diabetics considered separately, plasma magnesium concentrations were lower compared to healthy controls but these differences were not statistically significant. Magnesium 125-134 insulin Homo sapiens 41-48 3687594-2 1987 Paf-acether infusion was accompanied by decreases of urinary flow rate, calcium, and magnesium urinary excretion, whereas decreases of mean arterial pressure and glomerular filtration rate did not exceed 20% of control values for the highest perfusion rate of Paf-acether. Magnesium 85-94 PCNA clamp associated factor Rattus norvegicus 0-3 2827726-4 1987 A second class of magnesium ions participates directly in topoisomerase II mediated ATPase reactions and functions by providing the enzyme with a magnesium-ATP substrate. Magnesium 18-27 Topoisomerase 2 Drosophila melanogaster 58-74 2827726-4 1987 A second class of magnesium ions participates directly in topoisomerase II mediated ATPase reactions and functions by providing the enzyme with a magnesium-ATP substrate. Magnesium 18-27 Vacuolar H[+] ATPase 14kD subunit 1 Drosophila melanogaster 84-90 3690409-2 1987 In the magnesium-deficient rats, daily excretion of magnesium fell to very low values (1.2 +/- 0.2 vs. 52 +/- 12 microM.day-1.100 g body weight-1, p less than 0.05). Magnesium 7-16 Body weight QTL 17 Rattus norvegicus 137-145 2893595-5 1987 The magnitude of these contractions was magnesium-dependent; the contraction elicited was depressed and a dextral shift of the extracellular calcium concentration-response relation was noted in the presence of increased concentrations of Mg2+ (4.4 and 13.2 mM). Magnesium 40-49 mucin 7, secreted Homo sapiens 238-241 3665095-1 1987 Measurement of intracellular magnesium (Mg2+) may have advantages over serum Mg2+ measurements in the assessment of Mg2+ homeostasis in patients. Magnesium 29-38 mucin 7, secreted Homo sapiens 40-43 3037230-4 1987 Also, magnesium inhibited PIP2 hydrolysis and catalyzed the dephosphorylation of PIP2 to phosphatidylinositol-4-phosphate (PIP). Magnesium 6-15 prolactin induced protein Rattus norvegicus 26-29 3032994-8 1987 This conclusion is supported by the findings that changes in c-myc and c-fms mRNA levels in HL-60 cells treated with 100 nM 1,25(OH)2D3 in magnesium-deficient medium and those in standard magnesium medium were the same. Magnesium 139-148 MYC proto-oncogene, bHLH transcription factor Homo sapiens 61-66 3032994-8 1987 This conclusion is supported by the findings that changes in c-myc and c-fms mRNA levels in HL-60 cells treated with 100 nM 1,25(OH)2D3 in magnesium-deficient medium and those in standard magnesium medium were the same. Magnesium 139-148 colony stimulating factor 1 receptor Homo sapiens 71-76 3585222-0 1987 Comparison of the feedback effect of magnesium and calcium on parathyroid hormone secretion in man. Magnesium 37-46 parathyroid hormone Homo sapiens 62-81 2443508-4 1987 In agreement with the resistance of the selected cells to detachment by the peptide, 25-fold more Arg-Gly-Asp-containing peptide is required to prevent the attachment of these cells to fibronectin-coated surfaces than is needed to inhibit the attachment of MG-63 cells to the same substrate. Magnesium 257-259 fibronectin 1 Homo sapiens 185-196 3658552-2 1987 In adults, parathyroid hormone (PTH) secretion is negatively feedback regulated by acute changes in serum Mg concentration, but paradoxically Mg deficiency may lead to functional hypoparathyroidism and hypocalcemia. Magnesium 106-108 parathyroid hormone Homo sapiens 11-30 3658552-2 1987 In adults, parathyroid hormone (PTH) secretion is negatively feedback regulated by acute changes in serum Mg concentration, but paradoxically Mg deficiency may lead to functional hypoparathyroidism and hypocalcemia. Magnesium 106-108 parathyroid hormone Homo sapiens 32-35 3658552-3 1987 We hypothesized that in neonates, Mg administration will cause changes in PTH secretion and serum Ca concentration that will be inversely related to serum Mg status. Magnesium 34-36 parathyroid hormone Homo sapiens 74-77 3658552-4 1987 We also hypothesized that Mg administration will result in increased calcitonin (CT) secretion. Magnesium 26-28 calcitonin related polypeptide alpha Homo sapiens 69-79 3658552-4 1987 We also hypothesized that Mg administration will result in increased calcitonin (CT) secretion. Magnesium 26-28 calcitonin related polypeptide alpha Homo sapiens 81-83 3658552-7 1987 In both groups combined, baseline PTH correlated with baseline Mg (r = 0.72, p less than 0.005), and with baseline Ca (r = 0.68, p less than 0.005). Magnesium 63-65 parathyroid hormone Homo sapiens 34-37 3455617-1 1987 A newly developed calcium-sensitive dye, Fura-2, was employed in dispersed bovine parathyroid cells to study the effects of extracellular calcium and magnesium on cytosolic calcium concentration and parathyroid hormone (PTH) release. Magnesium 150-159 parathyroid hormone Bos taurus 199-218 3038243-3 1987 In the absence of added magnesium ions (Mg) in the perfusion medium low frequency stimulation of the Schaffer collateral-commissural pathway evoked a burst of population spikes in the CA1 cell body region. Magnesium 40-42 carbonic anhydrase 1 Rattus norvegicus 184-187 3505766-5 1987 Moreover, urinary Mg excretion per unit GFR (MgE, mg/dlGFR) and fractional excretion of MgUF filtered load (FEMgUF, %) fell (from 41 +/- 25 and 3.0 +/- 0.9 in C, respectively, to 26 +/- 12 (P less than 0.01) and 2.2 +/- 1.0 (P less than 0.05] in the last period, indicating that a greater fraction of filtered Mg was being reabsorbed by renal tubules. Magnesium 18-20 Rap guanine nucleotide exchange factor 5 Homo sapiens 40-43 2438383-5 1987 VIP-stimulated cyclic AMP accumulation was not decreased by agents that block calcium influx (verapamil, nifedipine, magnesium ions), or by calmodulin antagonists (trifluoperazine, calmidozolium). Magnesium 117-126 vasoactive intestinal peptide Rattus norvegicus 0-3 2438383-6 1987 In fact both verapamil (100 microM) and magnesium (14 mM) augmented VIP stimulation of cyclic AMP generation. Magnesium 40-49 vasoactive intestinal peptide Rattus norvegicus 68-71 3668499-3 1987 The catalytic activity of the ATPase depended upon the concentration of magnesium ions, the substrate (ATP) level and the ratio of magnesium ions to ATP. Magnesium 72-81 pMR0211_0073 Providencia stuartii 30-36 3668499-3 1987 The catalytic activity of the ATPase depended upon the concentration of magnesium ions, the substrate (ATP) level and the ratio of magnesium ions to ATP. Magnesium 131-140 pMR0211_0073 Providencia stuartii 30-36 3657779-0 1987 [Kinetics of dissociation of parvalbumin complexes with calcium and magnesium ions]. Magnesium 68-77 parvalbumin Homo sapiens 29-40 3657779-1 1987 Dissociation kinetics of parvalbumin complexes with calcium and magnesium ions were studied by means of stopped-flow method employing intrinsic protein fluorescence registration. Magnesium 64-73 parvalbumin Homo sapiens 25-36 3601271-1 1987 Insulin-dependent diabetic pregnant women are at risk for magnesium deficiency, predominantly because of increased urinary magnesium losses. Magnesium 58-67 insulin Homo sapiens 0-7 3601271-1 1987 Insulin-dependent diabetic pregnant women are at risk for magnesium deficiency, predominantly because of increased urinary magnesium losses. Magnesium 123-132 insulin Homo sapiens 0-7 3601271-3 1987 We tested the hypothesis that adverse fetal outcome (fetal loss before 20 weeks" gestation and/or congenital major malformations) is related to magnesium status (as assessed by determining serum magnesium levels) in insulin-dependent diabetic pregnant women, even after sonographic documentation of fetal viability. Magnesium 144-153 insulin Homo sapiens 216-223 3601271-3 1987 We tested the hypothesis that adverse fetal outcome (fetal loss before 20 weeks" gestation and/or congenital major malformations) is related to magnesium status (as assessed by determining serum magnesium levels) in insulin-dependent diabetic pregnant women, even after sonographic documentation of fetal viability. Magnesium 195-204 insulin Homo sapiens 216-223 3601271-8 1987 We speculate that decreased magnesium status may contribute to the high spontaneous abortion and malformation rate in insulin-dependent diabetic pregnant women. Magnesium 28-37 insulin Homo sapiens 118-125 2954955-4 1987 The binding of [3H]vasopressin to proteoliposomes is specific, saturable, reversible, and magnesium-dependent. Magnesium 90-99 arginine vasopressin Rattus norvegicus 19-30 3298232-1 1987 p21 isolated under nondenaturing conditions is obtained as a complex with guanosine nucleotides and magnesium ions. Magnesium 100-109 H3 histone pseudogene 16 Homo sapiens 0-3 3607001-0 1987 Kinetic reaction mechanism for magnesium binding to membrane-bound and soluble catechol O-methyltransferase. Magnesium 31-40 catechol-O-methyltransferase Homo sapiens 79-107 3607001-9 1987 This series of experiments provides evidence indicating that magnesium ions bind to both MB-COMT and SOL-COMT in a rapid equilibrium sequence prior to the addition of SAM. Magnesium 61-70 catechol-O-methyltransferase Homo sapiens 92-96 3607001-9 1987 This series of experiments provides evidence indicating that magnesium ions bind to both MB-COMT and SOL-COMT in a rapid equilibrium sequence prior to the addition of SAM. Magnesium 61-70 catechol-O-methyltransferase Homo sapiens 105-109 3606215-7 1987 Hard tap water provided less than 8% of the Canadian Recommended Nutrient Intake (RNI) for magnesium, less than 3% for calcium, and less than 1% for zinc. Magnesium 91-100 nuclear RNA export factor 1 Homo sapiens 5-8 3677481-7 1987 Correlation between plasma and CSF calcium and magnesium concentrations indicated that convulsions occurred when CSF magnesium and plasma calcium concentrations declined. Magnesium 47-56 granulocyte-macrophage colony-stimulating factor Ovis aries 113-116 3677481-7 1987 Correlation between plasma and CSF calcium and magnesium concentrations indicated that convulsions occurred when CSF magnesium and plasma calcium concentrations declined. Magnesium 117-126 granulocyte-macrophage colony-stimulating factor Ovis aries 31-34 3677481-7 1987 Correlation between plasma and CSF calcium and magnesium concentrations indicated that convulsions occurred when CSF magnesium and plasma calcium concentrations declined. Magnesium 117-126 granulocyte-macrophage colony-stimulating factor Ovis aries 113-116 3579913-4 1987 The mechanism for this inhibition was explored by studying the binding of 3H-PAF(0.08 nM) to GFP in Tyrodes buffer containing albumin (0.35%), Mg++ (1mM) and Ca++ (0.5mM). Magnesium 143-147 PCNA clamp associated factor Homo sapiens 77-80 3300911-1 1987 Contractility of all types of invertebrate and vertebrate muscle is dependent upon the actions and interactions of two divalent cations, viz, calcium (Ca2+) and magnesium (Mg2+) ions. Magnesium 161-170 mucin 7, secreted Homo sapiens 172-175 3584731-1 1987 Magnesium (Mg) is effective in the treatment of pregnancy-induced hypertension (PIH). Magnesium 0-9 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 80-83 3584731-1 1987 Magnesium (Mg) is effective in the treatment of pregnancy-induced hypertension (PIH). Magnesium 11-13 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 80-83 3585222-1 1987 Administration of high doses of magnesium is known to produce a decrease in parathyroid hormone (PTH) secretion in human patients but the effect of magnesium on the secretion of PTH in healthy man is not known. Magnesium 32-41 parathyroid hormone Homo sapiens 76-95 3585222-1 1987 Administration of high doses of magnesium is known to produce a decrease in parathyroid hormone (PTH) secretion in human patients but the effect of magnesium on the secretion of PTH in healthy man is not known. Magnesium 32-41 parathyroid hormone Homo sapiens 97-100 3585222-1 1987 Administration of high doses of magnesium is known to produce a decrease in parathyroid hormone (PTH) secretion in human patients but the effect of magnesium on the secretion of PTH in healthy man is not known. Magnesium 148-157 parathyroid hormone Homo sapiens 178-181 3585222-13 1987 These results suggest that magnesium was, on a molar basis, less potent than calcium in regulating PTH secretion in vivo, that the nature of the magnesium salt used must be kept in mind for the interpretation of the effect of magnesium on PTH secretion in vivo and that the decrease in plasma PTH can partly explain the larger urinary excretion of magnesium after MgSO4 than after MgPC. Magnesium 27-36 parathyroid hormone Homo sapiens 99-102 3033029-4 1987 Spontaneous burst firing of CA1 pyramidal cells in low calcium, high magnesium medium was reduced, indicating a partially postsynaptic inhibitory action of NPY on their dendrites. Magnesium 69-78 carbonic anhydrase 1 Rattus norvegicus 28-31 3028791-8 1987 These results have been used to construct a model for the interactions of Mg X GDP with the active site of p21 proteins. Magnesium 74-76 H3 histone pseudogene 16 Homo sapiens 107-110 3578772-2 1987 The technique is used to determine the binding constants of magnesium to human prothrombin. Magnesium 60-69 coagulation factor II, thrombin Homo sapiens 79-90 3441590-6 1987 There is a significant correlation between serum magnesium levels and serum levels of aldosterone, albumin, gamma-glutamyl transpeptidase and total pool of bile acids. Magnesium 49-58 inactive glutathione hydrolase 2 Homo sapiens 108-137 2953903-2 1987 The effect that Escherichia coli single-stranded DNA binding (SSB) protein has on the single-stranded DNA-dependent ATPase activity of RecA protein is shown to depend upon a number of variables such as order of addition, magnesium concentration, temperature and the type of single-stranded DNA substrate used. Magnesium 221-230 single-stranded DNA-binding protein Escherichia coli 62-65 2881671-4 1987 Insulin initiated immediate decreases in plasma calcium and magnesium. Magnesium 60-69 insulin Meleagris gallopavo 0-7 3295259-10 1987 However, this apparent stabilizing effect of SSB protein can be mimicked by pre-incubation of the RecA protein-single-stranded M13 DNA complex in low magnesium ion concentration, suggesting that this effect of SSB protein is indirect and is mediated through changes in the secondary structure of the DNA. Magnesium 150-159 single-stranded DNA-binding protein Escherichia coli 45-48 3295259-10 1987 However, this apparent stabilizing effect of SSB protein can be mimicked by pre-incubation of the RecA protein-single-stranded M13 DNA complex in low magnesium ion concentration, suggesting that this effect of SSB protein is indirect and is mediated through changes in the secondary structure of the DNA. Magnesium 150-159 single-stranded DNA-binding protein Escherichia coli 210-213 3427905-7 1987 Ribonuclease activity in the partially purified fraction was sensitive to EDTA, stimulated by magnesium, had a pH optimum at 9.0 and a Mr of 45,000. Magnesium 94-103 ribonuclease Saccharomyces cerevisiae S288C 0-12 3111814-10 1987 Histidine decarboxylase (HDC) activity in some tissues of Mg-deficient rats increased markedly. Magnesium 58-60 histidine decarboxylase Rattus norvegicus 0-23 2887399-0 1987 Effects of lysine and glutamic acid or [corrected] Mg++ on the conformations of C3 and B, and the activation of the alternative complement pathway. Magnesium 51-55 complement C3 Homo sapiens 80-88 2887399-1 1987 The conversion of C3 and B in the mixture of C3, B, D and Mg++ ions was inhibited in the presence of arginine and lysine, but not in the presence of glutamic acid and aspartic acid among other amino acids. Magnesium 58-62 complement C3 Homo sapiens 18-26 2887399-11 1987 The presence of Mg++ ions resulted in a decrease in the fluorescence intensity of C3 and B. Magnesium 16-20 complement C3 Homo sapiens 82-90 3111814-10 1987 Histidine decarboxylase (HDC) activity in some tissues of Mg-deficient rats increased markedly. Magnesium 58-60 histidine decarboxylase Rattus norvegicus 25-28 3111814-11 1987 The increased HDC activity dropped nearly to control levels after feeding them a 0.21% Mg diet for 2 days. Magnesium 87-89 histidine decarboxylase Rattus norvegicus 14-17 2959578-4 1987 Calcium transport and ATPase share the following properties: (i) magnesium was required with a K0.5 of 0.7 mM and maximal pumping ATPase activity at 5 mM Mg-ATP; (ii) at saturating magnesium concentrations, calcium increased ATP splitting activity up to three times with an apparent K0.5 close to 0.3 microM calcium; (iii) potassium stimulated the high calcium affinity Mg2+-dependent ATPase and calcium transport. Magnesium 65-74 dynein axonemal heavy chain 8 Homo sapiens 22-28 3326735-2 1987 The enzyme 6-pyruvoyl tetrahydropterin synthase consists of four identical subunits which convert dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin in the presence of magnesium. Magnesium 178-187 6-pyruvoyltetrahydropterin synthase Homo sapiens 11-47 2959578-4 1987 Calcium transport and ATPase share the following properties: (i) magnesium was required with a K0.5 of 0.7 mM and maximal pumping ATPase activity at 5 mM Mg-ATP; (ii) at saturating magnesium concentrations, calcium increased ATP splitting activity up to three times with an apparent K0.5 close to 0.3 microM calcium; (iii) potassium stimulated the high calcium affinity Mg2+-dependent ATPase and calcium transport. Magnesium 65-74 dynein axonemal heavy chain 8 Homo sapiens 130-136 2959578-4 1987 Calcium transport and ATPase share the following properties: (i) magnesium was required with a K0.5 of 0.7 mM and maximal pumping ATPase activity at 5 mM Mg-ATP; (ii) at saturating magnesium concentrations, calcium increased ATP splitting activity up to three times with an apparent K0.5 close to 0.3 microM calcium; (iii) potassium stimulated the high calcium affinity Mg2+-dependent ATPase and calcium transport. Magnesium 65-74 dynein axonemal heavy chain 8 Homo sapiens 130-136 2959578-4 1987 Calcium transport and ATPase share the following properties: (i) magnesium was required with a K0.5 of 0.7 mM and maximal pumping ATPase activity at 5 mM Mg-ATP; (ii) at saturating magnesium concentrations, calcium increased ATP splitting activity up to three times with an apparent K0.5 close to 0.3 microM calcium; (iii) potassium stimulated the high calcium affinity Mg2+-dependent ATPase and calcium transport. Magnesium 181-190 dynein axonemal heavy chain 8 Homo sapiens 22-28 3326976-0 1987 Blood pressure and plasma renin activity after magnesium supplementation in the spontaneously hypertensive rat: a study during developing and established hypertension. Magnesium 47-56 renin Rattus norvegicus 26-31 3598850-2 1987 Copper inhibited both enzymes while calcium and magnesium inhibited HIOMT; the mechanisms of these inhibitions are unknown at this stage. Magnesium 48-57 acetylserotonin O-methyltransferase Homo sapiens 68-73 3598850-3 1987 Calcium, magnesium, potassium, and sodium initially stimulated NAT activity, and as the cation concentration increased inhibitory activity was observed. Magnesium 9-18 bromodomain containing 2 Homo sapiens 63-66 3306179-3 1987 Magnesium (Mg2+) has been used extensively in obstetrics for the treatment of alterations of uterine contractility (premature labor) or increased neuronal and vascular smooth muscle activity (pre-eclampsia). Magnesium 0-9 mucin 7, secreted Homo sapiens 11-14 3625461-4 1987 Calcium and magnesium were uncompetitive inhibitors of HIOMT with respect to both substrates and binding of these cations to the enzyme prevents catalysis. Magnesium 12-21 acetylserotonin O-methyltransferase Bos taurus 55-60 3326976-1 1987 The effects of a dietary magnesium supplementation have been studied both on systolic blood pressure and plasma renin activity in the spontaneously hypertensive rat (SHR). Magnesium 25-34 renin Rattus norvegicus 112-117 3326976-4 1987 Plasma renin activity was similar after the two different diets in young SHR while it was greater in mature SHR receiving a high magnesium diet than in mature SHR receiving a normal diet. Magnesium 129-138 renin Rattus norvegicus 7-12 3438251-9 1987 Both 58 kd and 45 kd TdT displayed two optima for Mn++ (0.1 mM and 1 mM) and a single sharp optimum for Mg++ (2.5 mM). Magnesium 104-108 DNA nucleotidylexotransferase Bos taurus 21-24 3600928-0 1987 Magnesium, calcium and PTH relationships in dialysis patients after magnesium repletion. Magnesium 68-77 parathyroid hormone Homo sapiens 23-26 3600928-6 1987 Within 2 weeks of Mg repletion (by dialysis against 0.25 mM of Mg), the N-terminal PTH, total and ultrafiltrable serum Mg, and the total and ionized serum Ca increased in the low-Mg group. Magnesium 18-20 parathyroid hormone Homo sapiens 83-86 3600928-7 1987 There was a strong negative correlation between initial serum Mg and the percent change in N-terminal PTH (r = 0.833) at 2 weeks for all patients. Magnesium 62-64 parathyroid hormone Homo sapiens 102-105 3438251-10 1987 The two subunit 44 kd TdT exhibited a single but broad optimum for Mn++ (1 mM) and for Mg++ (10 mM). Magnesium 87-91 DNA nucleotidylexotransferase Bos taurus 22-25 2948558-7 1986 RecA protein is able to resist displacement by SSB protein at a lower magnesium concentration in acetate than in chloride buffer. Magnesium 70-79 single-stranded DNA-binding protein Escherichia coli 47-50 3819391-5 1986 Plasma magnesium (Mg2+) concentration was reduced during felodipine treatment while the intra-erythrocyte Mg2+ concentration tended to be increased. Magnesium 7-16 mucin 7, secreted Homo sapiens 18-21 3790523-0 1986 Calcium-proton and calcium-magnesium antagonisms in calmodulin: microcalorimetric and potentiometric analyses. Magnesium 27-36 calmodulin-1 Bos taurus 52-62 3801897-1 1986 The effect of magnesium-free medium on the electrical activity in CA3 of the rat hippocampal slice was examined. Magnesium 14-23 carbonic anhydrase 3 Rattus norvegicus 66-69 3801406-8 1986 By correlating calorimetric and fluorometric measurements of lipid lateral segregation and mixing of vesicle components, we can demonstrate that lipid segregation is at least strongly correlated with calcium-promoted coalescence of PA-PC vesicles and is essential to the magnesium-promoted interactions of vesicles of low PA contents. Magnesium 271-280 protocadherin 8 Homo sapiens 232-237 3817007-1 1986 Serum concentrations of calcium, magnesium, potassium and phosphate can be lowered experimentally by adrenaline, which also can stimulate the secretion of parathyroid hormone (PTH). Magnesium 33-42 parathyroid hormone Homo sapiens 155-174 3094377-5 1986 PDH activity assayed with high magnesium and calcium concentrations was significantly stimulated by insulin in adipocytes from control, but not obese or NIDDM subjects. Magnesium 31-40 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-3 3094377-5 1986 PDH activity assayed with high magnesium and calcium concentrations was significantly stimulated by insulin in adipocytes from control, but not obese or NIDDM subjects. Magnesium 31-40 insulin Homo sapiens 100-107 2428841-4 1986 Regulation of the PMI-1 epitope is independent of disassembly of the GPIIb-IIIa heterodimer, because it occurred at 22 degrees C and in response to mM magnesium as well as calcium. Magnesium 151-160 mannose phosphate isomerase Homo sapiens 18-23 2953122-0 1986 On the role of magnesium in the reaction of the pyruvate kinase from Salmonella typhimurium. Magnesium 15-24 pyruvate kinase Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 48-63 2953122-3 1986 The binding sites of the cation to the pyruvate kinases seem to be independent to those for phosphoenolpyruvate and adenosine 5"-diphosphate; changes in the magnesium concentration might be of physiological significance in relation to a rapid regeneration of adenosine 5"-triphosphate by means of the pyruvate kinase reaction. Magnesium 157-166 pyruvate kinase Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 39-54 2946669-6 1986 The presence of magnesium in the incubation medium was essential for the ATPase activity. Magnesium 16-25 dynein axonemal heavy chain 8 Homo sapiens 73-79 3539681-0 1986 Insulin induces opposite changes in plasma and erythrocyte magnesium concentrations in normal man. Magnesium 59-68 insulin Homo sapiens 0-7 3539681-5 1986 In contrast, erythrocyte magnesium levels were significantly increased (p less than 0.01) by insulin (100 mU/l), an effect entirely abolished by ouabain (5 X 10(-4) mol/l). Magnesium 25-34 insulin Homo sapiens 93-100 3539681-6 1986 These results suggest that insulin induces a shift of magnesium from the plasma to the erythrocytes both in vivo and in vitro. Magnesium 54-63 insulin Homo sapiens 27-34 3782584-1 1986 Intravenous infusion of synthetic bovine parathyroid hormone for 96 h increased 1,25-dihydroxyvitamin D, Mg, Ca, and hydroxyproline in plasma of pregnant cows within 16, 24, 48, and 72 h, respectively. Magnesium 105-107 parathyroid hormone Bos taurus 41-60 3740840-3 1986 The results show that activity of the enzyme in the assay coupled to malate dehydrogenase is underestimated, to varying extents, depending on magnesium concentration, buffer, and pH. Magnesium 142-151 LOC100856934 Zea mays 69-89 16664952-4 1986 Purified preparations were stable for at least 1 month at 0 to 4 degrees C. Magnesium ions were essential for activity of adenylate kinase in both directions of the reaction. Magnesium 76-85 Adenylate kinase, chloroplastic Zea mays 122-138 3719968-0 1986 Stepwise regression equations relating plasma or erythrocyte magnesium and other variables in insulin-dependent and non-insulin-dependent diabetics. Magnesium 61-70 insulin Homo sapiens 94-101 3795995-7 1986 It is suggested that they could be calcium-magnesium cells, calcium adsorbed by troponin complexes on actin filaments constituting one electrode, and magnesium complexed with ATP on myosin filaments the other. Magnesium 150-159 myosin heavy chain 14 Homo sapiens 182-188 3711069-7 1986 In the presence of zinc or magnesium ions, calmodulin was cleaved at the same sites as metal ion-free calmodulin under conditions where calmodulin would be expected to bind the respective ions. Magnesium 27-36 calmodulin Bos taurus 43-53 3017927-0 1986 Activation of magnesium-dependent, neutral sphingomyelinase by phosphatidylserine. Magnesium 14-23 sphingomyelin phosphodiesterase 2 Rattus norvegicus 35-59 3017927-2 1986 The delipidized plasma membrane showed only 18% of the activity of the magnesium-dependent, neutral sphingomyelinase in the untreated plasma membrane. Magnesium 71-80 sphingomyelin phosphodiesterase 2 Rattus norvegicus 92-116 3086539-3 1986 Six separate lines of evidence indicate that Mg and Mn are distinguishable from each other as regulators of adenylate cyclase: 1) After solubilization, adenylate cyclase is preferentially stimulated by Mn. Magnesium 45-47 adenylate cyclase 1 Rattus norvegicus 108-169 3711069-7 1986 In the presence of zinc or magnesium ions, calmodulin was cleaved at the same sites as metal ion-free calmodulin under conditions where calmodulin would be expected to bind the respective ions. Magnesium 27-36 calmodulin Bos taurus 102-112 3711069-7 1986 In the presence of zinc or magnesium ions, calmodulin was cleaved at the same sites as metal ion-free calmodulin under conditions where calmodulin would be expected to bind the respective ions. Magnesium 27-36 calmodulin Bos taurus 102-112 2870496-2 1986 A technique based on differential sensitivity of this enzyme activity to inhibition by magnesium ion is described that allows the discrimination of expression of human and hamster HMG-CoA synthase in these hybrids. Magnesium 87-96 3-hydroxy-3-methylglutaryl-CoA synthase 2 Homo sapiens 180-196 3485046-1 1986 During iv infusions of epidermal growth factor into sheep, serum calcium concentrations fell, whereas serum magnesium and serum immunoreactive PTH levels increased. Magnesium 108-117 EGF Ovis aries 23-46 2998811-5 1985 Calcium and magnesium ions (0-10 mM) increased agonist binding and decreased antagonist binding to adrenal and uterine angiotensin II receptors, an effect mediated by changes in both affinity and number of receptors for the two peptides. Magnesium 12-21 angiotensinogen Rattus norvegicus 119-133 3008156-4 1986 At intracellular levels of calmodulin the binding and activation of autophosphorylation were cooperative functions of magnesium and calcium concentration. Magnesium 118-127 calmodulin 1 Homo sapiens 27-37 2879581-6 1986 Arylsulfatase A was inhibited by sulfate, sulfite, silver, magnesium, manganese and calcium ions and arylsulfatase B by chloride, sulfate, sulfite and silver ions. Magnesium 59-68 arylsulfatase A Equus caballus 0-15 3801726-1 1986 Magnesium (Mg2+) plays a significant role in the electrical stability of the heart and hypomagnesemia may predispose patients to arrhythmias and digitalis toxicity. Magnesium 0-9 mucin 7, secreted Homo sapiens 11-14 2872947-2 1986 The incorporation of phosphate in TH is observed after incubation of TH with labelled ATP and magnesium without the need for an exogenous protein kinase. Magnesium 94-103 tyrosine hydroxylase Rattus norvegicus 34-36 2872947-2 1986 The incorporation of phosphate in TH is observed after incubation of TH with labelled ATP and magnesium without the need for an exogenous protein kinase. Magnesium 94-103 tyrosine hydroxylase Rattus norvegicus 69-71 3792136-2 1986 The binding of calcium to calmodulin is a cooperative and selective process that is modulated by magnesium. Magnesium 97-106 calmodulin 1 Homo sapiens 26-36 3539735-5 1986 Insulin treatment (for 4 weeks) after 6 weeks of diabetes, prevented the magnesium depletion in both the tissues and red blood cells. Magnesium 73-82 insulin Oryctolagus cuniculus 0-7 2436535-6 1986 CSF calcium did not prove to be related to either suicidal behavior or the diagnosis of major depression; on the other hand, CSF magnesium was found to be significantly lower in the suicide attempters and also correlated with CSF 5-HIAA. Magnesium 129-138 colony stimulating factor 2 Homo sapiens 125-128 2436535-6 1986 CSF calcium did not prove to be related to either suicidal behavior or the diagnosis of major depression; on the other hand, CSF magnesium was found to be significantly lower in the suicide attempters and also correlated with CSF 5-HIAA. Magnesium 129-138 colony stimulating factor 2 Homo sapiens 125-128 3643079-7 1986 The alternative-pathway C3/C5 convertase complex was formed by adding purified factors B and D to the hybrid in the presence of magnesium. Magnesium 128-137 complement C2 Homo sapiens 24-40 3732563-0 1986 Viscosimetric studies of the effect of magnesium ions on DNA in the presence of H1 histone and bovine serum albumin. Magnesium 39-48 albumin Homo sapiens 102-115 3089951-9 1986 In the purified system, only arginine and lysine prevented the conversion of C3 and B, when C3, B and D were incubated in the presence of Mg++ and amino-acids. Magnesium 138-142 complement C3 Homo sapiens 77-85 3944537-7 1986 This decrease was attributed to the high production rate of the yolk-protein precursor vitellogenin, which binds both calcium and magnesium. Magnesium 130-139 LOC100136735 Oncorhynchus mykiss 87-99 3086631-1 1986 Due to the distribution of Mg2+-binding ligands, such as DNA, RNA, or Mg2+-binding proteins, e.g. within the intermembranous space of mitochondria, intracellular magnesium is compartmentalized. Magnesium 162-171 mucin 7, secreted Homo sapiens 27-30 3086631-1 1986 Due to the distribution of Mg2+-binding ligands, such as DNA, RNA, or Mg2+-binding proteins, e.g. within the intermembranous space of mitochondria, intracellular magnesium is compartmentalized. Magnesium 162-171 mucin 7, secreted Homo sapiens 70-73 3523056-11 1986 Platelets from Mg-deficient rats become more sensitive to thrombin. Magnesium 15-17 coagulation factor II Rattus norvegicus 58-66 3822766-0 1986 Additive effects of glucagon and vasopressin on renal Mg reabsorption and urine concentrating ability in the rat. Magnesium 54-56 arginine vasopressin Rattus norvegicus 33-44 3544106-7 1986 The loop of Henle appears to be the major nephron site where magnesium reabsorption is regulated possibly by cAMP-mediated hormones including parathyroid hormones, calcitonin, glucagon and antidiuretic hormone. Magnesium 61-70 arginine vasopressin Homo sapiens 189-209 2939551-6 1986 Solubilization of IC in the presence of Mg-EGTA or in C2-deficient serum resulted in a markedly delayed binding of IC to RBC, indicating the importance of an intact classical pathway in preparing the IC for binding to RBC-CR1. Magnesium 40-42 complement C3b/C4b receptor 1 (Knops blood group) Homo sapiens 222-225 2866707-4 1985 Short- or longer-term lowering of blood pressure with the calcium-channel blocker, nifedipine, or with calcium or magnesium supplementation is associated with a shift of renin system activity and calcium metabolic indexes back to average normotensive values in those subjects most susceptible to these hypotensive agents. Magnesium 114-123 renin Homo sapiens 170-175 3003627-1 1985 Adenosine deaminase reversibly increased the amplitude and the quantum content of the end-plate potentials (EPPs) recorded from superficial muscle fibers of frog sartorius preparations in which twitches have been prevented with high-magnesium solutions. Magnesium 233-242 adenosine deaminase Homo sapiens 0-19 4091006-2 1985 Calcitonin caused a transient increase of the cellular calcium and magnesium concentration, but did not affect the intracellular concentration of other electrolytes. Magnesium 67-76 calcitonin-related polypeptide alpha Rattus norvegicus 0-10 3915858-5 1985 In order to know whether the inhibitory effect of GTP(gamma F) was due to the release of the metal, magnesium was replaced for manganese (a paramagnetic ion) and the paramagnetic effect of manganese on the fluorine NMR signal from the GTP(gamma F)-tubulin-metal complex was followed. Magnesium 100-109 mitochondrial ribosome associated GTPase 1 Homo sapiens 50-61 3915858-5 1985 In order to know whether the inhibitory effect of GTP(gamma F) was due to the release of the metal, magnesium was replaced for manganese (a paramagnetic ion) and the paramagnetic effect of manganese on the fluorine NMR signal from the GTP(gamma F)-tubulin-metal complex was followed. Magnesium 100-109 mitochondrial ribosome associated GTPase 1 Homo sapiens 54-61 3912195-0 1985 On the insulin effect on the magnesium homeostasis. Magnesium 29-38 insulin Homo sapiens 7-14 3912195-2 1985 insulin per kg body mass is followed by a decline of the plasma magnesium levels of about 15 to 20 percent of the basal levels. Magnesium 64-73 insulin Homo sapiens 0-7 3912195-3 1985 This effect is explained as a result of transport of extracellular magnesium into the intracellular space of the insulin-dependent tissues, and is discussed on the basis of known insulin-magnesium interactions at the receptor level. Magnesium 67-76 insulin Homo sapiens 113-120 3912195-3 1985 This effect is explained as a result of transport of extracellular magnesium into the intracellular space of the insulin-dependent tissues, and is discussed on the basis of known insulin-magnesium interactions at the receptor level. Magnesium 67-76 insulin Homo sapiens 179-186 3912195-3 1985 This effect is explained as a result of transport of extracellular magnesium into the intracellular space of the insulin-dependent tissues, and is discussed on the basis of known insulin-magnesium interactions at the receptor level. Magnesium 187-196 insulin Homo sapiens 113-120 3912195-3 1985 This effect is explained as a result of transport of extracellular magnesium into the intracellular space of the insulin-dependent tissues, and is discussed on the basis of known insulin-magnesium interactions at the receptor level. Magnesium 187-196 insulin Homo sapiens 179-186 2856782-4 1985 We observed renin-linked, heterogeneous deviations in circulating levels of the divalent cations, magnesium and ionized calcium, in addition to deviations in the calcium-regulating hormones, parathyroid hormone (PTH), calcitonin (CT), and 1,25 dihydroxyvitamin D (1,25 D). Magnesium 98-107 renin Homo sapiens 12-17 2932536-3 1985 Magnesium is proposed to stabilize the hormone-receptor-guanine nucleotide regulatory protein complex, whereas sodium appears to destabilize this ternary complex. Magnesium 0-9 nuclear receptor subfamily 4 group A member 1 Homo sapiens 39-55 4067656-5 1985 Three days after the end of treatment liver calcium in the magnesium-deficient CCl4-treated rats was higher than in any other group. Magnesium 59-68 C-C motif chemokine ligand 4 Rattus norvegicus 79-83 4067656-7 1985 In control and magnesium-deficient animals receiving CCl4 treatment, the liver collagen levels were significantly higher than in untreated rats. Magnesium 15-24 C-C motif chemokine ligand 4 Rattus norvegicus 53-57 4067656-8 1985 The magnesium-deficient rats receiving CCl4 have higher liver collagen than the controls receiving CCl4. Magnesium 4-13 C-C motif chemokine ligand 4 Rattus norvegicus 39-43 4067656-8 1985 The magnesium-deficient rats receiving CCl4 have higher liver collagen than the controls receiving CCl4. Magnesium 4-13 C-C motif chemokine ligand 4 Rattus norvegicus 99-103 4067656-12 1985 The synergistic action between magnesium deficiency and ethanol therefore appears to be analogous to that observed with CCl4. Magnesium 31-40 C-C motif chemokine ligand 4 Rattus norvegicus 120-124 2997170-1 1985 Limited tryptic digestion of pig kidney fructose-1,6-bisphosphatase in the presence of magnesium ions results in the formation of an active enzyme derivative which is no longer inhibited by the allosteric effector AMP. Magnesium 87-96 fructose-bisphosphatase 1 Sus scrofa 40-67 3840173-5 1985 After magnesium therapy, only 5 of the patients had a rise in the serum 1,25-(OH)2D concentration into or above the normal range despite elevated levels of serum immunoreactive PTH. Magnesium 6-15 parathyroid hormone Homo sapiens 177-180 3840173-7 1985 The serum vitamin D-binding protein concentration, assessed in 11 patients, was low (273 +/- 86 micrograms/ml) before magnesium therapy, but normalized (346 +/- 86 micrograms/ml) after magnesium repletion. Magnesium 118-127 GC vitamin D binding protein Homo sapiens 10-35 3840173-7 1985 The serum vitamin D-binding protein concentration, assessed in 11 patients, was low (273 +/- 86 micrograms/ml) before magnesium therapy, but normalized (346 +/- 86 micrograms/ml) after magnesium repletion. Magnesium 185-194 GC vitamin D binding protein Homo sapiens 10-35 2934691-3 1985 The reaction for the magnesium-activated ATP-ase located in the apical cytoplasm of ciliated cells was negative in one case and slightly positive in the same case on year later; in our second case, the ATP-ase reaction was variable, slightly to moderately positive, in the same biopsy. Magnesium 21-30 dynein axonemal heavy chain 8 Homo sapiens 41-48 2934691-3 1985 The reaction for the magnesium-activated ATP-ase located in the apical cytoplasm of ciliated cells was negative in one case and slightly positive in the same case on year later; in our second case, the ATP-ase reaction was variable, slightly to moderately positive, in the same biopsy. Magnesium 21-30 dynein axonemal heavy chain 8 Homo sapiens 202-209 2994742-0 1985 Inhibition of smooth muscle 5"-nucleotidase by imidazole and its reversal by magnesium. Magnesium 77-86 5' nucleotidase, ecto Rattus norvegicus 28-43 3878227-2 1985 Previous studies have shown that the concentration of red blood cell (RBC) magnesium is significantly lower in subjects carrying an HLA-BW 35 antigen (p less than 0.001) than in non-carriers. Magnesium 75-84 BW35 Homo sapiens 136-141 3878227-5 1985 A significant negative correlation between sialic acid and RBC magnesium concentrations was observed for the whole population tested (n 57, p less than 0.005), 61% of the BW 35+ and only 25% of the BW 35- individuals having sialic acid values above, and magnesium values below the overall mean (p less than 0.01). Magnesium 63-72 BW35 Homo sapiens 171-176 3841078-2 1985 We observed: a low level of blood magnesium in all diabetics a lower level of P T H, more pronounced with poorly controlled diabetes. Magnesium 34-43 parathyroid hormone Homo sapiens 78-83 3907234-4 1985 A negative correlation was found between serum magnesium levels and HbA1. Magnesium 47-56 hemoglobin subunit alpha 1 Homo sapiens 68-72 4037508-7 1985 The effect of dietary Mg on CSF Mg concentrations approached significance (P less than 0.10). Magnesium 22-24 granulocyte-macrophage colony-stimulating factor Ovis aries 28-31 3902485-0 1985 The effect of potassium, calcium and magnesium concentration on insulin and glucagon secretion of the perfused dog pancreas. Magnesium 37-46 insulin Canis lupus familiaris 64-71 3902485-6 1985 An increase of magnesium ions from 1.0 mMol/l to 2.5-7.5 mMol/l strikingly inhibits insulin and glucagon release by approximately 50%, which is compensated for insulin by increasing the Ca2+-content of the medium. Magnesium 15-24 insulin Canis lupus familiaris 84-91 3902485-6 1985 An increase of magnesium ions from 1.0 mMol/l to 2.5-7.5 mMol/l strikingly inhibits insulin and glucagon release by approximately 50%, which is compensated for insulin by increasing the Ca2+-content of the medium. Magnesium 15-24 insulin Canis lupus familiaris 160-167 2410553-1 1985 Recombinant interferon-gamma (IFN-gamma) in contact with human embryonic fibroblasts or with a great variety of cells from different animal species was phosphorylated in the presence of [gamma-32P]ATP and magnesium ions by a protein kinase released in the culture medium. Magnesium 205-214 interferon gamma Homo sapiens 12-28 2995147-0 1985 [Effect of ACTH and hydrocortisone on sodium, potassium, calcium and magnesium levels and Ca2-ATPase activity in skeletal muscles]. Magnesium 69-78 proopiomelanocortin Homo sapiens 11-15 2410553-1 1985 Recombinant interferon-gamma (IFN-gamma) in contact with human embryonic fibroblasts or with a great variety of cells from different animal species was phosphorylated in the presence of [gamma-32P]ATP and magnesium ions by a protein kinase released in the culture medium. Magnesium 205-214 interferon gamma Homo sapiens 30-39 2990471-0 1985 Bovine heart cytochrome c oxidase preparations contain high affinity binding sites for magnesium as well as for zinc, copper, and heme iron. Magnesium 87-96 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 13-33 2931795-3 1985 The basal and Mg-stimulated ATP-ase activities were higher, while the DNP-stimulated ATP-ase activity was lower in diabetics compared to controls. Magnesium 14-16 dynein axonemal heavy chain 8 Homo sapiens 28-35 2989160-2 1985 It was shown that inhibition of the Na,K ATP-ase-dependent cation transport through the lymphocyte membrane by means of incubation of the cells with various specific inhibitors of the enzyme (ouabain, vanadate) or depletion of the magnesium cations from the incubation medium caused the rise in the percentage of early rosettes, having no influence on the late E rosette percentage. Magnesium 231-240 dynein axonemal heavy chain 8 Homo sapiens 41-48 4011446-5 1985 Unlike other B-cruciform transitions the transition in d(AT)n-d(AT)n has a low activation energy and the transition is facilitated by the presence of magnesium ions. Magnesium 150-159 Dopamine transporter Drosophila melanogaster 57-59 4011446-5 1985 Unlike other B-cruciform transitions the transition in d(AT)n-d(AT)n has a low activation energy and the transition is facilitated by the presence of magnesium ions. Magnesium 150-159 Dopamine transporter Drosophila melanogaster 64-66 2990452-6 1985 Interestingly, the effect of EGF was only detected in magnesium containing medium. Magnesium 54-63 epidermal growth factor Homo sapiens 29-32 2579962-2 1985 Digestion with phospholipase A2 indicated that ghosts prepared in the presence of Mg++ as the only divalent cation retained the normal phospholipid asymmetry characteristic of intact erythrocytes. Magnesium 82-86 phospholipase A2 group IB Homo sapiens 15-31 2992571-0 1985 Exchange rates and numbers of annular lipids for the calcium and magnesium ion dependent adenosinetriphosphatase. Magnesium 65-74 ATPase Na+/K+ transporting subunit beta 1 Homo sapiens 89-112 3922781-0 1985 Magnesium enhances human pancreatic elastase digestion of 125I-labeled elastin. Magnesium 0-9 elastin Homo sapiens 71-78 3922781-1 1985 The effect of some divalent cations, especially Mg++, on elastinolysis by porcine or human pancreatic elastase has been determined using 125Iodine-labeled elastin as substrate. Magnesium 48-52 elastin Homo sapiens 57-64 3922781-2 1985 Elastin degradation was significantly increased in the presence of 10(-3) M Mg++. Magnesium 76-80 elastin Homo sapiens 0-7 3893197-1 1985 Canine liver aldehyde dehydrogenases (ALDH) (aldehyde:NAD oxidoreductase; EC 1.2.1.3) are analogous to enzymes identified in human and other mammalian liver tissue in regard to subcellular localization, affinity for substrates, inhibition by disulfiram, and effects of magnesium ions on enzyme activity. Magnesium 269-278 hydroxysteroid 17-beta dehydrogenase 6 Homo sapiens 58-72 3986998-0 1985 Direct spectrophotometry of magnesium in serum after reaction with hexokinase and glucose-6-phosphate dehydrogenase. Magnesium 28-37 hexokinase 1 Homo sapiens 67-77 3986998-0 1985 Direct spectrophotometry of magnesium in serum after reaction with hexokinase and glucose-6-phosphate dehydrogenase. Magnesium 28-37 glucose-6-phosphate dehydrogenase Homo sapiens 82-115 3986998-1 1985 We describe a simple method for determining magnesium in serum by using hexokinase (EC 2.7.1.1) and glucose-6-phosphate dehydrogenase (EC 1.1.1.49). Magnesium 44-53 hexokinase 1 Homo sapiens 72-82 3846596-2 1985 The TPK previously detected in the murine lymphoma (LSTRA) induced by the Moloney murine leukemia virus phosphorylates gastrin, the apparent Km is 65 microM and the maximum rate 1900 pmol/min per mg; the kinase is more efficient with MnCl2 than with MgCl2, is stimulated by NaVO3 and inhibited by ZnCl2. Magnesium 196-198 gastrin Homo sapiens 119-126 4039272-2 1985 There is an increase in the number of [3H]forskolin binding sites when membranes are incubated with GppNHp or NaF in the presence of magnesium. Magnesium 133-142 C-X-C motif chemokine ligand 8 Homo sapiens 110-113 2982391-2 1985 In the present report, the aggregation response to a variety of inducers of platelet aggregation, the content of the dense granule constituents ATP, ADP, serotonin and calcium, the secretion of ATP, ADP, and calcium induced by thrombin, the total content of magnesium, the incorporation of 14C-adenine in the cytoplasmic pool of adenine nucleotides, as well as the content of intracellular cyclic-AMP, have been quantitated in six patients with CHS. Magnesium 258-267 coagulation factor II, thrombin Homo sapiens 227-235 3988027-6 1985 This is the first study to show an effect of PTH on renal magnesium transport in avian species. Magnesium 58-67 parathyroid hormone Bos taurus 45-48 3871637-7 1985 When ATP-citrate lyase was assayed at a concentration of Mg.ATP well below Km, it was found that phosphorylation of the enzyme correlated well with a decrease of approx. Magnesium 57-59 ATP citrate lyase Rattus norvegicus 5-22 2857551-1 1985 This study examined the inhibition of azide as a probe of the magnesium regulation of beef heart mitochondrial ATPase (F1) catalysis. Magnesium 62-71 ATP synthase F1 subunit epsilon Homo sapiens 97-117 3886415-1 1985 UNLABELLED: In order to investigate the influence of insulin secretion on serum magnesium concentrations 33 insulin-dependent diabetics and 10 control subjects were studied. Magnesium 80-89 insulin Homo sapiens 53-60 3980304-2 1985 With Rosco Neosensitabs agar diffusion agreement with reference minimal inhibitory concentrations was 98.5%, while with the MS-2 system it was 100% if calcium and magnesium-supplemented MS-2 broth was used. Magnesium 163-172 MS2 Homo sapiens 186-190 3965449-0 1985 Kinetic studies of calcium and magnesium binding to troponin C. Magnesium 31-40 tenascin C Homo sapiens 52-62 3155695-3 1985 Synexin binding to plasma membrane coated beads showed a specific requirement for calcium (K1 2 = 200 microM) and was insensitive to other divalent cations such as magnesium, strontium and barium. Magnesium 164-173 annexin A7 Homo sapiens 0-7 3974261-0 1985 Calmodulin: calcium, potassium, and magnesium ion multiple equilibria and kinetics for interconversion, including the effect of repeated stimulation. Magnesium 36-45 calmodulin 1 Homo sapiens 0-10 3965449-12 1985 Magnesium binding to the calcium-magnesium sites of TR2 and TN-C occurs by the same two-step binding mechanism with a smaller value for K0 and a 5-fold larger rate constant of dissociation. Magnesium 0-9 nuclear receptor subfamily 2 group C member 1 Homo sapiens 52-55 3965449-12 1985 Magnesium binding to the calcium-magnesium sites of TR2 and TN-C occurs by the same two-step binding mechanism with a smaller value for K0 and a 5-fold larger rate constant of dissociation. Magnesium 0-9 tenascin C Homo sapiens 60-64 3965449-12 1985 Magnesium binding to the calcium-magnesium sites of TR2 and TN-C occurs by the same two-step binding mechanism with a smaller value for K0 and a 5-fold larger rate constant of dissociation. Magnesium 33-42 nuclear receptor subfamily 2 group C member 1 Homo sapiens 52-55 3965449-12 1985 Magnesium binding to the calcium-magnesium sites of TR2 and TN-C occurs by the same two-step binding mechanism with a smaller value for K0 and a 5-fold larger rate constant of dissociation. Magnesium 33-42 tenascin C Homo sapiens 60-64 2940816-6 1985 Primarily from these findings, it was proposed that the mechanism of gizzard muscle contraction involves ATP-induced changes in the morphology of myosin filaments which are reversibly altered by enzymic phosphorylation and dephosphorylation of myosin light chains in the presence of relatively high concentrations of magnesium. Magnesium 317-326 myosin, heavy chain 15 Gallus gallus 146-152 3914811-5 1985 Besides the probable importance of a nearly normalized glucose metabolism in IDDM patients during pregnancy, it is postulated that the altered pattern of plasma proteins in diabetes and pregnancy, and possibly also exogenous insulin may influence the serum concentrations of zinc and magnesium seen at the end of pregnancy. Magnesium 284-293 insulin Homo sapiens 225-232 2940816-6 1985 Primarily from these findings, it was proposed that the mechanism of gizzard muscle contraction involves ATP-induced changes in the morphology of myosin filaments which are reversibly altered by enzymic phosphorylation and dephosphorylation of myosin light chains in the presence of relatively high concentrations of magnesium. Magnesium 317-326 myosin, heavy chain 15 Gallus gallus 244-250 3158341-8 1985 In the absence of solvent, the interaction of magnesium with the calcium-deprived ATPase was also characterized from the point of view of phosphoenzyme formation from ATP or Pi at pH 7 in the absence of potassium: we found that calcium-independent phosphorylation was slower when phosphate was added to SR vesicles preincubated with magnesium that when magnesium was added to vesicles preincubated with phosphate, suggesting that preincubation with magnesium had depleted the phosphate-reactive conformation of the ATPase. Magnesium 46-55 dynein axonemal heavy chain 8 Homo sapiens 82-88 3966559-4 1985 Intraduodenal infusions of calcium, magnesium, and zinc significantly stimulated CCK-33, PP, and gastrin release. Magnesium 36-45 cholecystokinin Canis lupus familiaris 81-84 3966559-4 1985 Intraduodenal infusions of calcium, magnesium, and zinc significantly stimulated CCK-33, PP, and gastrin release. Magnesium 36-45 pancreatic polypeptide Canis lupus familiaris 89-91 3966559-4 1985 Intraduodenal infusions of calcium, magnesium, and zinc significantly stimulated CCK-33, PP, and gastrin release. Magnesium 36-45 gastrin Canis lupus familiaris 97-104 3966559-6 1985 Intravenous magnesium increased CCK-33 to 123% of basal levels but did not stimulate PP and gastrin levels. Magnesium 12-21 cholecystokinin Canis lupus familiaris 32-35 3966559-8 1985 This study shows that calcium, magnesium, and zinc can stimulate release of CCK-33, PP, and gastrin in much the same manner. Magnesium 31-40 cholecystokinin Canis lupus familiaris 76-79 3966559-8 1985 This study shows that calcium, magnesium, and zinc can stimulate release of CCK-33, PP, and gastrin in much the same manner. Magnesium 31-40 pancreatic polypeptide Canis lupus familiaris 84-86 3966559-8 1985 This study shows that calcium, magnesium, and zinc can stimulate release of CCK-33, PP, and gastrin in much the same manner. Magnesium 31-40 gastrin Canis lupus familiaris 92-99 3970646-4 1985 The Dead Sea has a uniquely high concentration of calcium, magnesium, sodium, potassium, and chloride. Magnesium 59-68 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 9-12 3158341-8 1985 In the absence of solvent, the interaction of magnesium with the calcium-deprived ATPase was also characterized from the point of view of phosphoenzyme formation from ATP or Pi at pH 7 in the absence of potassium: we found that calcium-independent phosphorylation was slower when phosphate was added to SR vesicles preincubated with magnesium that when magnesium was added to vesicles preincubated with phosphate, suggesting that preincubation with magnesium had depleted the phosphate-reactive conformation of the ATPase. Magnesium 46-55 dynein axonemal heavy chain 8 Homo sapiens 515-521 3158341-8 1985 In the absence of solvent, the interaction of magnesium with the calcium-deprived ATPase was also characterized from the point of view of phosphoenzyme formation from ATP or Pi at pH 7 in the absence of potassium: we found that calcium-independent phosphorylation was slower when phosphate was added to SR vesicles preincubated with magnesium that when magnesium was added to vesicles preincubated with phosphate, suggesting that preincubation with magnesium had depleted the phosphate-reactive conformation of the ATPase. Magnesium 333-342 dynein axonemal heavy chain 8 Homo sapiens 82-88 3158341-8 1985 In the absence of solvent, the interaction of magnesium with the calcium-deprived ATPase was also characterized from the point of view of phosphoenzyme formation from ATP or Pi at pH 7 in the absence of potassium: we found that calcium-independent phosphorylation was slower when phosphate was added to SR vesicles preincubated with magnesium that when magnesium was added to vesicles preincubated with phosphate, suggesting that preincubation with magnesium had depleted the phosphate-reactive conformation of the ATPase. Magnesium 333-342 dynein axonemal heavy chain 8 Homo sapiens 82-88 3158341-8 1985 In the absence of solvent, the interaction of magnesium with the calcium-deprived ATPase was also characterized from the point of view of phosphoenzyme formation from ATP or Pi at pH 7 in the absence of potassium: we found that calcium-independent phosphorylation was slower when phosphate was added to SR vesicles preincubated with magnesium that when magnesium was added to vesicles preincubated with phosphate, suggesting that preincubation with magnesium had depleted the phosphate-reactive conformation of the ATPase. Magnesium 333-342 dynein axonemal heavy chain 8 Homo sapiens 82-88 2842070-8 1985 The levels of Mg++-stimulated cyclic phosphodiesterase in cpd-1, cpd-2, bd, and cr-1 at 0.2 microM cyclic 3",5"-AMP were 199%, 137%, 329%, and 293% of that of wild-type. Magnesium 14-18 cerebellar ataxia, infantile nonprogressive, autosomal recessive Homo sapiens 58-63 3981211-5 1985 The most likely origin of Mg in CSF in epilepsy is the CNS tissue from which Mg is released. Magnesium 26-28 colony stimulating factor 2 Homo sapiens 32-35 3871757-3 1985 The population study performed on 32 subjects showed the occurrence of a higher antibody response (P less than 0.01) and a lower red blood cell Mg level, among the Bw35 individuals. Magnesium 144-146 BW35 Homo sapiens 164-168 3981211-5 1985 The most likely origin of Mg in CSF in epilepsy is the CNS tissue from which Mg is released. Magnesium 77-79 colony stimulating factor 2 Homo sapiens 32-35 2939302-10 1985 Moreover, TA and Mg have a compensatory effect on GAC1, GM1 and Gjc in Hanks" solution, but their actions are not cumulative. Magnesium 17-19 ankyrin repeat domain 12 Homo sapiens 50-54 3831319-0 1985 Effect of magnesium ions on rat pineal N-acetyltransferase (EC 2.3.1.5) activity. Magnesium 10-19 N-acetyltransferase 1 Rattus norvegicus 39-58 3831319-1 1985 N-Acetyltransferase (NAT) activity at night and following isoproterenol treatment in intact animals was higher in rats pretreated with magnesium than in controls. Magnesium 135-144 N-acetyltransferase 1 Rattus norvegicus 0-19 3831319-1 1985 N-Acetyltransferase (NAT) activity at night and following isoproterenol treatment in intact animals was higher in rats pretreated with magnesium than in controls. Magnesium 135-144 N-acetyltransferase 1 Rattus norvegicus 21-24 3831319-3 1985 A similar effect was observed in vitro, where magnesium increased norepinephrine-stimulated NAT activity in organ-cultured pineal glands, suggesting that magnesium acts primarily on the pineal gland as opposed to some other peripheral or central site. Magnesium 46-55 N-acetyltransferase 1 Rattus norvegicus 92-95 3831319-3 1985 A similar effect was observed in vitro, where magnesium increased norepinephrine-stimulated NAT activity in organ-cultured pineal glands, suggesting that magnesium acts primarily on the pineal gland as opposed to some other peripheral or central site. Magnesium 154-163 N-acetyltransferase 1 Rattus norvegicus 92-95 3831319-4 1985 This enhancement of NAT activity by magnesium would presumably lead to increased melatonin production; and as melatonin has been shown to decrease serum magnesium levels, a negative feedback mechanism may exist. Magnesium 36-45 N-acetyltransferase 1 Rattus norvegicus 20-23 3831319-4 1985 This enhancement of NAT activity by magnesium would presumably lead to increased melatonin production; and as melatonin has been shown to decrease serum magnesium levels, a negative feedback mechanism may exist. Magnesium 153-162 N-acetyltransferase 1 Rattus norvegicus 20-23 3914581-3 1985 It has generally been believed that the physiological roles for magnesium ions (Mg2+) in cardiac and vascular smooth muscle are limited to regulation of contractile proteins, sarcoplasmic reticular membrane transport of calcium ions (Ca2+), cofactor in ATPase activities and metabolic regulation of energy-dependent cytoplasmic and mitochondrial pathways. Magnesium 64-73 mucin 7, secreted Homo sapiens 80-83 6525341-4 1984 Comparison of guanidinium and magnesium salts indicated that the substitution of guanidinium ion for Mg2+ decreases the preferential hydration and increases the preferential salt binding, suggesting that the perturbation by guanidinium ion binding of the surface free energy is greater than that by Mg2+ ion. Magnesium 30-39 mucin 7, secreted Homo sapiens 101-104 6094938-8 1984 Divalent cations Mg, Ca and Mn also increase [125I]iodo-ANF specific binding, with Mn being the most active cation. Magnesium 17-19 natriuretic peptide A Bos taurus 56-59 3982956-0 1985 Stimulation by glucagon and PTH of Ca and Mg reabsorption in the superficial distal tubule of the rat kidney. Magnesium 42-44 parathyroid hormone Rattus norvegicus 28-31 3982956-4 1985 The Ca and Mg reabsorptive capacity of the distal segment was increased by glucagon and by PTH. Magnesium 11-13 parathyroid hormone Rattus norvegicus 91-94 3982956-8 1985 Finally, the data presented here, together with those previously reported, indicate that the increase of Ca and Mg renal reabsorption observed with glucagon and PTH results from an effect located in both Henle"s loop, where the bulk of Ca and Mg is reabsorbed, and the distal tubule. Magnesium 112-114 parathyroid hormone Rattus norvegicus 161-164 3982956-8 1985 Finally, the data presented here, together with those previously reported, indicate that the increase of Ca and Mg renal reabsorption observed with glucagon and PTH results from an effect located in both Henle"s loop, where the bulk of Ca and Mg is reabsorbed, and the distal tubule. Magnesium 243-245 parathyroid hormone Rattus norvegicus 161-164 6499696-8 1984 Magnesium has been demonstrated to be important in cell energetics (Mg++-activated ATPase), in maintenance of the integrity of cell membranes, retardation of cell loss of potassium, as well as enhancing repletion of cell potassium. Magnesium 0-9 dynein axonemal heavy chain 8 Homo sapiens 83-89 6499943-3 1984 On the other hand, the establishment of communication through new permeable junctions, when ASS- and ASL- cells were mixed, was dependent on the presence of extracellular calcium and magnesium. Magnesium 183-192 argininosuccinate lyase Homo sapiens 101-104 6238120-6 1984 The DAF inhibitory effect on EAC14 or EAC43 was not overcome by supplying an excess of C2 or factor B, but the alternative pathway C3 convertase could be assembled in the presence of Ni++, or nonphysiological concentrations of Mg++, which enhances the binding affinity of factor B for C3b. Magnesium 227-231 CD55 molecule (Cromer blood group) Homo sapiens 4-7 6096046-5 1984 Amino-terminal PTH (N-PTH) varied directly with the concentration of magnesium; carboxy-terminal PTH (C-PTH) was raised in all patients. Magnesium 69-78 parathyroid hormone Homo sapiens 15-18 6096046-5 1984 Amino-terminal PTH (N-PTH) varied directly with the concentration of magnesium; carboxy-terminal PTH (C-PTH) was raised in all patients. Magnesium 69-78 parathyroid hormone Homo sapiens 20-25 6096046-5 1984 Amino-terminal PTH (N-PTH) varied directly with the concentration of magnesium; carboxy-terminal PTH (C-PTH) was raised in all patients. Magnesium 69-78 parathyroid hormone Homo sapiens 22-25 6096046-5 1984 Amino-terminal PTH (N-PTH) varied directly with the concentration of magnesium; carboxy-terminal PTH (C-PTH) was raised in all patients. Magnesium 69-78 parathyroid hormone Homo sapiens 22-25 6096046-6 1984 When magnesium was injected, both N-PTH and C-PTH rose regardless of the initial concentration, indicating that hypomagnesaemia was limiting PTH secretion. Magnesium 5-14 parathyroid hormone Homo sapiens 34-39 6096046-6 1984 When magnesium was injected, both N-PTH and C-PTH rose regardless of the initial concentration, indicating that hypomagnesaemia was limiting PTH secretion. Magnesium 5-14 parathyroid hormone Homo sapiens 36-39 6096046-6 1984 When magnesium was injected, both N-PTH and C-PTH rose regardless of the initial concentration, indicating that hypomagnesaemia was limiting PTH secretion. Magnesium 5-14 parathyroid hormone Homo sapiens 46-49 6096046-7 1984 The clearance of endogenous PTH was measured in one patient, after injection of magnesium. Magnesium 80-89 parathyroid hormone Homo sapiens 28-31 6096046-12 1984 It is suggested that the concentration of PTH rather than the degree of hypomagnesaemia is the most important factor determining the responsiveness of target tissues to PTH in magnesium deficiency. Magnesium 176-185 parathyroid hormone Homo sapiens 42-45 6510551-0 1984 Interaction of extracellular calcium and magnesium in the regulation of cytosolic calcium and PTH release in dispersed bovine parathyroid cells. Magnesium 41-50 parathyroid hormone Bos taurus 94-97 6510551-1 1984 We examined the effects of varying the extracellular magnesium (Mg2+) concentration at different extracellular calcium (Ca2+) concentrations on cytosolic Ca2+ and PTH release in dispersed bovine parathyroid cells using the fluorescent, Ca2+-sensitive dye QUIN-2. Magnesium 53-62 parathyroid hormone Bos taurus 163-166 6389078-5 1984 Renin release is stimulated by hyperpolarisation of the juxtaglomerular cell induced by beta 1-agonists, parathyroid hormone, glucagon, magnesium and low cytosol calcium. Magnesium 136-145 renin Homo sapiens 0-5 6096046-12 1984 It is suggested that the concentration of PTH rather than the degree of hypomagnesaemia is the most important factor determining the responsiveness of target tissues to PTH in magnesium deficiency. Magnesium 176-185 parathyroid hormone Homo sapiens 169-172 6501644-3 1984 Characterization of binding assay conditions of human growth hormone indicated: that divalent ions (calcium or magnesium) were required for maximal binding, that binding was time dependent and saturable, that specific binding was proportional to the quantity of membrane protein assayed, and that bound radiolabeled human growth hormone was displaced similarly with either nonradiolabeled bovine prolactin or ovine prolactin. Magnesium 111-120 growth hormone 1 Homo sapiens 54-68 6593713-1 1984 Intracellular levels of free Mg2+ in human erythrocytes were determined by 31P NMR spectroscopy in 26 fasted subjects and were correlated with blood pressures and serum levels of total magnesium (bound and free Mg2+) and ionized calcium from the same subjects in a seated position. Magnesium 185-194 mucin 7, secreted Homo sapiens 29-32 6090650-6 1984 The Mg- and ATP-dependent 45Ca accumulation was stimulated by the presence of either K or Na in the medium, was hyperbolically activated by increasing the Ca2+ concentration in the medium, was stimulated by calmodulin and inhibited by orthovanadate (10(-4) M) or LaCl3 (10(-3) M). Magnesium 4-6 calmodulin-2 Canis lupus familiaris 207-217 6209443-3 1984 HDC activities in the spleen of Mg-deficient rats on the 4th, 6th and 8th day increased to levels about 5.5, 15.5 and 35 times as high as the respective control values; the activities in the skin increased to about 37, 7 and 10 times the control values on the 4th, 6th and 8th day, respectively; while in the peritoneal mast cells, the activities increased to about 1.2 and 2.2 times the control values on the 6th and 8th day, respectively. Magnesium 32-34 histidine decarboxylase Rattus norvegicus 0-3 6204984-7 1984 A mean value of 4.0 X 10(7) M-1 was obtained for the association constant of TnC X TnT using DANZ-TnC and IAE-TnC as probes in the presence of calcium or magnesium ions. Magnesium 154-163 tenascin Oryctolagus cuniculus 77-80 6504410-0 1984 The hypocalcemia associated with magnesium infusion is mediated through parathyroid hormone. Magnesium 33-42 parathyroid hormone Homo sapiens 72-91 6384712-3 1984 With 50 microM Mg++ in the medium, insulin selectively stimulated the phosphorylation of a 47kD phosphoprotein, Protein F1. Magnesium 15-19 insulin Homo sapiens 35-42 6384712-3 1984 With 50 microM Mg++ in the medium, insulin selectively stimulated the phosphorylation of a 47kD phosphoprotein, Protein F1. Magnesium 15-19 growth associated protein 43 Homo sapiens 112-122 6384712-6 1984 At 1 mM Mg++, insulin selectively decreased the phosphorylation of the alpha-subunit of pyruvate dehydrogenase. Magnesium 8-12 insulin Homo sapiens 14-21 6204984-9 1984 The results show that the presence of magnesium ion in the Ca2+-Mg2+ sites strengthens the TnC-TnI and the TnC-TnT interactions and suggest that the troponin structure would be stabilized. Magnesium 38-47 tenascin Oryctolagus cuniculus 91-94 6204984-9 1984 The results show that the presence of magnesium ion in the Ca2+-Mg2+ sites strengthens the TnC-TnI and the TnC-TnT interactions and suggest that the troponin structure would be stabilized. Magnesium 38-47 tenascin Oryctolagus cuniculus 107-110 6204984-10 1984 This likely results from the effect of magnesium ion on the Ca2+-Mg2+ domains of TnC. Magnesium 39-48 tenascin Oryctolagus cuniculus 81-84 6589391-0 1984 Prostaglandin-vasopressin interactions on the renal handling of calcium and magnesium. Magnesium 76-85 arginine vasopressin Rattus norvegicus 14-25 6329167-1 1984 The deinhibitor protein, which protects the multisubstrate protein phosphatase from inhibition by inhibitor-1 and the modulator protein, stabilizes the enzyme in its active conformation preventing its conversion to the ATP,Mg-dependent enzyme form and controls the dephosphorylation of inhibitor-1, was shown to exist under active and inactive forms. Magnesium 223-225 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 98-109 6747730-0 1984 Reduction of plasma lecithin--cholesterol acyltransferase activity by acute magnesium deficiency in the rat. Magnesium 76-85 lecithin cholesterol acyltransferase Rattus norvegicus 20-57 6747730-3 1984 The plasma activity of lecithin--cholesterol acyltransferase was markedly diminished in fasting magnesium-deficient rats (54% reduction) and plasma high density lipoprotein (HDL) free cholesterol was significantly increased in the HDL fraction. Magnesium 96-105 lecithin cholesterol acyltransferase Rattus norvegicus 23-60 6465832-4 1984 Visualization of ALP activity is accomplished by the use of buffered p-toluidinium 5-bromo-4-chloro-indolyl phosphate and magnesium ions. Magnesium 122-131 alkaline phosphatase, placental Homo sapiens 17-20 6547864-0 1984 Interaction of metal ions with gastrointestinal hormones: binding studies of Mg++ to biologically active analogs of little gastrin and minigastrin. Magnesium 77-81 gastrin Homo sapiens 123-130 6373930-2 1984 The deposition of C3b from normal or C2-deficient serum was time- and magnesium-dependent, implying a role for the alternative pathway. Magnesium 70-79 complement C3 Homo sapiens 18-21 6738367-0 1984 Renal and systemic magnesium metabolism during chronic continuous PTH infusion in normal subjects. Magnesium 19-28 parathyroid hormone Homo sapiens 66-69 6738367-2 1984 Whereas acute experimental PTH administration uniformly results in enhanced renal magnesium reabsorption in many species, including humans, numerous clinical reports have documented renal magnesium wasting in human primary hyperparathyroidism. Magnesium 82-91 parathyroid hormone Homo sapiens 27-30 6738367-8 1984 During days 7-12 of PTH administration, net intestinal magnesium absorption increased sufficiently to result in a return to control magnesium balance. Magnesium 55-64 parathyroid hormone Homo sapiens 20-23 6738367-8 1984 During days 7-12 of PTH administration, net intestinal magnesium absorption increased sufficiently to result in a return to control magnesium balance. Magnesium 132-141 parathyroid hormone Homo sapiens 20-23 16663670-5 1984 The Mg:ATP kinetics for the plasma membrane ATPase were hyperbolic in both the absence and presence of vanadate. Magnesium 4-6 ATPase Zea mays 44-50 6086522-9 1984 Total secretion of beta-Glu elicited by magnesium-leached chrysotile was reduced by 43% from the untreated sample, but kinetic monitoring indicates that this reduction in inflammatory potential is only significant during the first 12 h of an 18-h culture period. Magnesium 40-49 glucuronidase, beta Rattus norvegicus 19-27 6328747-8 1984 In contrast, FSV-encoded P130 was found to fractionate with the plasma membrane marker when cells were analyzed in low salt in the presence of magnesium. Magnesium 143-152 nucleolar and coiled-body phosphoprotein 1 Homo sapiens 25-29 6329167-1 1984 The deinhibitor protein, which protects the multisubstrate protein phosphatase from inhibition by inhibitor-1 and the modulator protein, stabilizes the enzyme in its active conformation preventing its conversion to the ATP,Mg-dependent enzyme form and controls the dephosphorylation of inhibitor-1, was shown to exist under active and inactive forms. Magnesium 223-225 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 286-297 6423182-2 1984 Plasma concentrations of magnesium were lowest in the insulin treated group (mean 0.84 (SEM 0.01) mmol/1; 2.0 (0.02) mg/100 ml), intermediate in the non-diabetics (mean 0.89 (SEM 0.01) mmol/1; 2.2 (0.02) mg/100 ml), and highest in the non-insulin-treated diabetics (mean 0.95 (SEM 0.02) mmol/1; 2.3 (0.05) mg/100 ml). Magnesium 25-34 insulin Homo sapiens 54-61 6423182-2 1984 Plasma concentrations of magnesium were lowest in the insulin treated group (mean 0.84 (SEM 0.01) mmol/1; 2.0 (0.02) mg/100 ml), intermediate in the non-diabetics (mean 0.89 (SEM 0.01) mmol/1; 2.2 (0.02) mg/100 ml), and highest in the non-insulin-treated diabetics (mean 0.95 (SEM 0.02) mmol/1; 2.3 (0.05) mg/100 ml). Magnesium 25-34 insulin Homo sapiens 239-246 6423182-3 1984 In all diabetics plasma magnesium concentrations were inversely related to plasma glucose values (rs = -0.33; p less than 0.01) and in non-insulin-treated patients to plasma insulin concentrations (rs = -0.28; p less than 0.05), the former confirming previous observations. Magnesium 24-33 insulin Homo sapiens 174-181 6423182-5 1984 This direct relation of plasma magnesium concentration with glucose disposal was unexplained by its influence on insulin secretion but was related to insulin sensitivity; hence magnesium may be an important determinant of insulin sensitivity in maturity onset diabetes. Magnesium 31-40 insulin Homo sapiens 150-157 6423182-5 1984 This direct relation of plasma magnesium concentration with glucose disposal was unexplained by its influence on insulin secretion but was related to insulin sensitivity; hence magnesium may be an important determinant of insulin sensitivity in maturity onset diabetes. Magnesium 31-40 insulin Homo sapiens 150-157 6696123-10 1984 It is concluded that, in vivo, administration of HCT 1) stimulates reabsorption of Na, Cl, Mg, Ca, and K by the thick ascending limb, and 2) consistently enhances Mg and Ca reabsorption by the whole kidney by enhancing reabsorption in the loop of Henle. Magnesium 91-93 cytochrome P450 family 7 subfamily B member 1 Rattus norvegicus 49-54 6712659-2 1984 This assignment is supported by the action of alkaline phosphatase and by production of an identical peak on incubation of 3MG with yeast hexokinase in a buffer containing adenosine triphosphate and Mg++ ions. Magnesium 199-203 hexokinase Saccharomyces cerevisiae S288C 138-148 6712666-1 1984 Purified platelet thrombospondin binds to immobilized fibrinogen if both Ca++ and Mg++ are present. Magnesium 82-86 fibrinogen beta chain Homo sapiens 54-64 6712666-5 1984 The requirement for Ca++ and Mg++ for optimal binding to fibrinogen is also manifest by the Mr 120,000/140,000 thermolytic fragments. Magnesium 29-33 fibrinogen beta chain Homo sapiens 57-67 6320929-7 1984 Magnesium enhanced the ability of lead to inhibit G6PD. Magnesium 0-9 glucose-6-phosphate dehydrogenase Homo sapiens 50-54 6233802-1 1984 The calcium-dependent acylphosphate formed by the calcium transport ATPase of cardiac sarcoplasmic reticulum and the calcium-, calmodulin-dependent phosphoester(s) of sarcoplasmic reticulum fractions formed by a calcium-, calmodulin-dependent membrane-bound protein kinase can be distinguished by removal of calcium and/or magnesium by EDTA or hydroxylamine treatment of the acid denaturated membranes. Magnesium 323-332 calmodulin 1 Homo sapiens 127-137 6696123-10 1984 It is concluded that, in vivo, administration of HCT 1) stimulates reabsorption of Na, Cl, Mg, Ca, and K by the thick ascending limb, and 2) consistently enhances Mg and Ca reabsorption by the whole kidney by enhancing reabsorption in the loop of Henle. Magnesium 163-165 cytochrome P450 family 7 subfamily B member 1 Rattus norvegicus 49-54 6737825-0 1984 Parathyroid hormone secretion rate in magnesium deficient calves. Magnesium 38-47 parathyroid hormone Bos taurus 0-19 6229606-4 1984 However, saturating (8 mM) magnesium antagonized the effect of aluminum on both forms of hexokinase activity. Magnesium 27-36 hexokinase 1 Homo sapiens 89-99 6319953-1 1984 We studied the relative potencies of extracellular calcium and magnesium in inhibiting PTH release and dopamine-stimulated cAMP accumulation in dispersed bovine parathyroid cells. Magnesium 63-72 parathyroid hormone Bos taurus 87-90 6319953-2 1984 At 1.0 mmol/L calcium, PTH release was half-maximally suppressed by 1.8 mmol/L magnesium. Magnesium 79-88 parathyroid hormone Bos taurus 23-26 6319953-4 1984 With 1.0 mmol/L EGTA and no added calcium (free calcium less than 10(-8) mol/L), half-maximal inhibition of PTH release accumulation occurred at 10 to 15 mmol/L magnesium. Magnesium 161-170 parathyroid hormone Bos taurus 108-111 6319953-7 1984 These results do not fit a model in which calcium and magnesium independently and additively inhibit PTH release in dispersed bovine parathyroid cells. Magnesium 54-63 parathyroid hormone Bos taurus 101-104 6319953-8 1984 Instead, they demonstrate that the inhibition of PTH release and agonist-stimulated cAMP accumulation by magnesium are critically dependent on the presence of extracellular calcium but not vice versa. Magnesium 105-114 parathyroid hormone Bos taurus 49-52 6143601-5 1984 The optimum activity of glutamine synthetase is dependent on the Mg++ to ATP ratio in the reaction mixture rather than on the magnesium or ATP concentrations. Magnesium 65-69 glutamate-ammonia ligase Gallus gallus 24-44 6143601-5 1984 The optimum activity of glutamine synthetase is dependent on the Mg++ to ATP ratio in the reaction mixture rather than on the magnesium or ATP concentrations. Magnesium 126-135 glutamate-ammonia ligase Gallus gallus 24-44 6709029-5 1984 Parathyroid hormone levels fell rapidly in response to magnesium infusion, from 13.1 +/- 2.5 to 7.8 +/- 0.7 pg per milliliter at 30 minutes, and were significantly below base-line levels for two hours despite frank hypocalcemia. Magnesium 55-64 parathyroid hormone Homo sapiens 0-19