PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27086859-7	2016	These results show that pinacidl, cromakalim, diazoxide and nicorandil-sensitive KATP channels exist in murine myometrium, which are composed of SUR2B and Kir6.2.	Cromakalim	34-44	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	145-150
29291445-0	2018	Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis.	Cromakalim	65-75	elastin	Rattus norvegicus	173-180
27753906-8	2016	Diazoxide (300 muM), cromakalim (10 muM) nicorandil (10 muM) which is known to activate KATP channel also completely blocked vasomotion in a glibenclamide sensitive manner.	Cromakalim	21-31	latexin	Homo sapiens	36-39
27753906-8	2016	Diazoxide (300 muM), cromakalim (10 muM) nicorandil (10 muM) which is known to activate KATP channel also completely blocked vasomotion in a glibenclamide sensitive manner.	Cromakalim	21-31	latexin	Homo sapiens	36-39
27086859-7	2016	These results show that pinacidl, cromakalim, diazoxide and nicorandil-sensitive KATP channels exist in murine myometrium, which are composed of SUR2B and Kir6.2.	Cromakalim	34-44	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	155-161
26535899-9	2015	Together, these studies suggest that cromakalim is a potent ocular hypotensive agent that lowers IOP via activation of Kir6.2 containing KATP channels, its effect is additive when used in combination with the commonly used glaucoma drug latanoprost, and is not toxic to cells and tissues of the aqueous humor outflow pathway, making it a candidate for future therapeutic development.	Cromakalim	37-47	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	119-125
26626290-8	2016	DISCUSSION: Cromakalim suppresses morphine-induced astrocyte activation significantly by suppressing the c-Jun N-terminal kinase pathway, resulting in a reduced release of interleukin-1beta and the attenuation of morphine chronic antinociceptive tolerance.	Cromakalim	12-22	interleukin 1 beta	Mus musculus	172-189
22467893-13	2012	The selective NADPH oxidase NOX2 inhibitor gp91ds-tat (10(-6) mol/L) and pretreatment with isoflurane (1.15% and 2.3%) restored relaxation in response to levcromakalim in arteries treated with d-glucose (20 mmol/L).	Cromakalim	154-167	cytochrome b-245 beta chain	Homo sapiens	28-32
23628292-3	2013	RESULTS: ACE inhibition and/or HS diet eliminated endothelium-dependent arteriolar dilation to acetylcholine, endothelium-independent dilation to the NO donor sodium nitroprusside, the prostacyclin analogs carbacyclin and iloprost, and the KATP channel opener cromakalim; and eliminated arteriolar constriction during KATP channel blockade with glibenclamide.	Cromakalim	260-270	angiotensin I converting enzyme	Homo sapiens	9-12
22369430-5	2012	Our study establishes that nicorandil and cromakalim, but not glibenclamide, prevent AURC-induced bladder dysfunction via up-regulation of both K(IR)6.1 and K(IR)6.2 with a subsequent decrease in oxidative stress and decreased induction of apoptosis in the bladder.	Cromakalim	42-52	potassium inwardly-rectifying channel, subfamily J, member 8	Rattus norvegicus	144-152
22369430-5	2012	Our study establishes that nicorandil and cromakalim, but not glibenclamide, prevent AURC-induced bladder dysfunction via up-regulation of both K(IR)6.1 and K(IR)6.2 with a subsequent decrease in oxidative stress and decreased induction of apoptosis in the bladder.	Cromakalim	42-52	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	157-165
21833470-0	2011	A novel cromakalim analogue induces cell cycle arrest and apoptosis in human cervical carcinoma HeLa cells through the caspase- and mitochondria-dependent pathway.	Cromakalim	8-18	caspase 9	Homo sapiens	119-126
22003059-10	2012	Cromakalim, a K(ATP) channel agonist, prevented both membrane depolarization and Akt phosphorylation with ischemia.	Cromakalim	0-10	thymoma viral proto-oncogene 1	Mus musculus	81-84
22144717-6	2012	In vitro CGRP release was studied after application of levcromakalim (1 microM) and diazoxide (10 microM) to freshly isolated rat dura mater, TG and TNC.	Cromakalim	55-68	calcitonin-related polypeptide alpha	Rattus norvegicus	9-13
17825556-5	2008	The Kir6.2/SUR2A-B agonist cromakalim showed similar potency in activating the K(ATP) channels of normokalaemic and K(+)-depleted rats but reduced efficacy in K(+)-depleted rats.	Cromakalim	27-37	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	4-10
21907492-7	2011	Furthermore, preadministration of an astroglial gap junction decoupler carbenoxolone (10 mug) completely reversed the inhibitory effects of CRO treatment on the hyperalgesia and allodynia and phosphorylation of NR1 and NR2B receptors and the subsequent activation of Ca(2+)-dependent signals Ca(2+)/calmodulin-dependent kinase II and cyclic adenosine monophosphate (cAMP) response element binding protein.	Cromakalim	140-143	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	211-214
21907492-7	2011	Furthermore, preadministration of an astroglial gap junction decoupler carbenoxolone (10 mug) completely reversed the inhibitory effects of CRO treatment on the hyperalgesia and allodynia and phosphorylation of NR1 and NR2B receptors and the subsequent activation of Ca(2+)-dependent signals Ca(2+)/calmodulin-dependent kinase II and cyclic adenosine monophosphate (cAMP) response element binding protein.	Cromakalim	140-143	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	219-223
20964536-6	2011	The Katp and Kca agonists cromakalim and NS 1619 produced vasodilation that was impaired after FPI more in males than in females.	Cromakalim	26-36	casein kappa	Homo sapiens	13-16
18945825-5	2009	In cell-attached mode, the unitary amplitude of levcromakalim-induced native and recombinant heteroconcatemeric Kir6.1-Kir6.2 K(ATP) channels also showed strong inward rectification at positive membrane potentials.	Cromakalim	48-61	potassium inwardly rectifying channel subfamily J member 8	Sus scrofa	112-118
18945825-5	2009	In cell-attached mode, the unitary amplitude of levcromakalim-induced native and recombinant heteroconcatemeric Kir6.1-Kir6.2 K(ATP) channels also showed strong inward rectification at positive membrane potentials.	Cromakalim	48-61	potassium inwardly rectifying channel subfamily J member 11	Sus scrofa	119-125
20409940-7	2009	The channel openers diazoxide, pinacidil, and cromakalim all decreased this type of stimulated ANF secretion.	Cromakalim	46-56	natriuretic peptide A	Rattus norvegicus	95-98
17264019-13	2007	MMP-2 caused relaxation of phenylephrine contraction in IVC pretreated with cromakalim (10(-7) mol/L), an activator of K(ATP) channels.	Cromakalim	76-86	matrix metallopeptidase 2	Homo sapiens	0-5
13679582-11	2003	Diazoxide, a sulfonylurea receptor 1 (SUR1)selective KATP-channel opener, prevented DA modulation by H2O2, glutamate, and GABA, whereas cromakalim, a SUR2-selective opener, did not.	Cromakalim	136-146	ATP-binding cassette sub-family C member 9	Cavia porcellus	150-154
16837559-3	2006	In identified DA neurons acutely dissociated from rat substantia nigra pars compacta (SNc), both the mitochondrial metabolic inhibitor rotenone and the sulfonylurea receptor subtype (SUR) 1-selective K(ATP) channel opener (KCO) diazoxide induced neuronal hyperpolarization and abolished action potential firing, but the SUR2B-selective KCO cromakalim exerted little effect, suggesting that functional K(ATP) channels in rat SNc DA neurons are mainly composed of SUR1.	Cromakalim	340-350	ATP binding cassette subfamily C member 8	Rattus norvegicus	152-189
16418275-8	2006	Pharmacological experiments showed that the channel response to the SUR1 agonist diazoxide, SUR2A/B agonist cromakalim, SUR1 antagonist tolbutamide, and the SUR1/SUR2A/B-antagonist glibenclamide matched the SURs expression pattern.	Cromakalim	108-118	ATP binding cassette subfamily C member 8	Homo sapiens	68-72
15910880-5	2005	We here review current knowledge on the molecular basis of the interaction of classical K(ATP) channel openers (cromakalim, pinacidil, diazoxide) with SUR.	Cromakalim	112-122	ATP binding cassette subfamily C member 8	Homo sapiens	151-154
11181944-6	2001	Levcromakalim showed a modestly suppressive effect on the AII-induced angiogenesis.	Cromakalim	0-13	angiotensinogen	Rattus norvegicus	58-61
12681433-3	2003	VEGF(165) markedly increased cell proliferation using 5-bromo-2"-deoxyuridine incorporation and chemotactic migration using transwell chamber in human umbilical vein endothelial cells, those of which were significantly suppressed by pretreatment with KR-31372 and levcromakalim concentration dependently.	Cromakalim	264-277	vascular endothelial growth factor A	Homo sapiens	0-4
12681433-5	2003	KR-31372 (10(-6)-10(-4) M) and levcromakalim (10(-5) M) concentration-dependently suppressed the VEGF(165)-induced increases in KDR/Flk-1 tyrosine phosphorylation as well as the extracellular signal-related kinase 1/2 (ERK1/2), p38 MAK and p125(FAK) tyrosine phosphorylation.	Cromakalim	31-44	vascular endothelial growth factor A	Homo sapiens	97-101
12681433-5	2003	KR-31372 (10(-6)-10(-4) M) and levcromakalim (10(-5) M) concentration-dependently suppressed the VEGF(165)-induced increases in KDR/Flk-1 tyrosine phosphorylation as well as the extracellular signal-related kinase 1/2 (ERK1/2), p38 MAK and p125(FAK) tyrosine phosphorylation.	Cromakalim	31-44	kinase insert domain receptor	Homo sapiens	128-131
12681433-5	2003	KR-31372 (10(-6)-10(-4) M) and levcromakalim (10(-5) M) concentration-dependently suppressed the VEGF(165)-induced increases in KDR/Flk-1 tyrosine phosphorylation as well as the extracellular signal-related kinase 1/2 (ERK1/2), p38 MAK and p125(FAK) tyrosine phosphorylation.	Cromakalim	31-44	kinase insert domain receptor	Homo sapiens	132-137
12681433-5	2003	KR-31372 (10(-6)-10(-4) M) and levcromakalim (10(-5) M) concentration-dependently suppressed the VEGF(165)-induced increases in KDR/Flk-1 tyrosine phosphorylation as well as the extracellular signal-related kinase 1/2 (ERK1/2), p38 MAK and p125(FAK) tyrosine phosphorylation.	Cromakalim	31-44	mitogen-activated protein kinase 3	Homo sapiens	178-217
12681433-5	2003	KR-31372 (10(-6)-10(-4) M) and levcromakalim (10(-5) M) concentration-dependently suppressed the VEGF(165)-induced increases in KDR/Flk-1 tyrosine phosphorylation as well as the extracellular signal-related kinase 1/2 (ERK1/2), p38 MAK and p125(FAK) tyrosine phosphorylation.	Cromakalim	31-44	mitogen-activated protein kinase 3	Homo sapiens	219-225
12681433-5	2003	KR-31372 (10(-6)-10(-4) M) and levcromakalim (10(-5) M) concentration-dependently suppressed the VEGF(165)-induced increases in KDR/Flk-1 tyrosine phosphorylation as well as the extracellular signal-related kinase 1/2 (ERK1/2), p38 MAK and p125(FAK) tyrosine phosphorylation.	Cromakalim	31-44	mitogen-activated protein kinase 1	Homo sapiens	228-231
12681433-5	2003	KR-31372 (10(-6)-10(-4) M) and levcromakalim (10(-5) M) concentration-dependently suppressed the VEGF(165)-induced increases in KDR/Flk-1 tyrosine phosphorylation as well as the extracellular signal-related kinase 1/2 (ERK1/2), p38 MAK and p125(FAK) tyrosine phosphorylation.	Cromakalim	31-44	SEC23 interacting protein	Homo sapiens	240-244
12681433-5	2003	KR-31372 (10(-6)-10(-4) M) and levcromakalim (10(-5) M) concentration-dependently suppressed the VEGF(165)-induced increases in KDR/Flk-1 tyrosine phosphorylation as well as the extracellular signal-related kinase 1/2 (ERK1/2), p38 MAK and p125(FAK) tyrosine phosphorylation.	Cromakalim	31-44	protein tyrosine kinase 2	Homo sapiens	245-248
12783661-8	2003	A dose-dependent decreasing effect on mPAP was elicited by levcromakalim and cromakalim in the hypoxic rats.	Cromakalim	62-72	phospholipid phosphatase 1	Mus musculus	38-42
12783661-9	2003	CONCLUSION: Although K(ATP) activity is probably not directly involved in the development of chronic hypoxic pulmonary hypertension in rats, both levcromakalim and cromakalim decrease the increased mPAP induced by chronic hypoxia by activating K(ATP) of SMCs from pulmonary arteries, therefore diminishing the inhibitory effect of hypoxia on other K(+) channels.	Cromakalim	146-159	phospholipid phosphatase 1	Mus musculus	198-202
12783661-9	2003	CONCLUSION: Although K(ATP) activity is probably not directly involved in the development of chronic hypoxic pulmonary hypertension in rats, both levcromakalim and cromakalim decrease the increased mPAP induced by chronic hypoxia by activating K(ATP) of SMCs from pulmonary arteries, therefore diminishing the inhibitory effect of hypoxia on other K(+) channels.	Cromakalim	149-159	phospholipid phosphatase 1	Mus musculus	198-202
11387506-11	2001	Under sham injury conditions, vasopressin (40 pg/mL) coadministered with cromakalim or NS1619 blunted dilation in response to these K(+) channel agonists, whereas chelerythrine partially restored such impaired vasodilation for cromakalim but not NS1619.	Cromakalim	73-83	vasopressin	Sus scrofa	30-41
12839872-13	2003	Ouabain (1 micro M, 90 min) powerfully blocked bradykinin-induced, nitric oxide-mediated vasodilatation as well as that induced by the nitrovasodilator, glyceryl trinitrate, but that induced by the K(ATP) channel opener, levcromakalim, was hardly affected.	Cromakalim	221-234	kininogen 1	Bos taurus	47-57
11504785-4	2001	The protein kinase A inhibitor Rp-adenosine 3",5"-cyclic monophosphothioate triethylamine (Rp-cAMPS) inhibited the ability of isoproterenol to modulate levcromakalim relaxation.	Cromakalim	152-165	calmodulin 2, pseudogene 1	Rattus norvegicus	94-99
10625598-7	2000	The SUR2 segment containing the 12th through 17th predicted transmembrane domains, TMD12-17, confers sensitivity to the benzopyran, cromakalim, and the pyridine, pinacidil, whereas an SUR1 segment which includes TMD6-11 and the first nucleotide-binding fold, NBF1, controls responsiveness to the benzothiadiazine, diazoxide.	Cromakalim	132-142	ATP binding cassette subfamily C member 9	Homo sapiens	4-8
11120759-6	2000	Catalase, which dismutates H(2)O(2) to form water and oxygen, inhibited EDHF-mediated relaxation and hyperpolarization, but it did not affect endothelium-independent relaxation following treatment with the K(+) channel opener levcromakalim.	Cromakalim	226-239	catalase	Mus musculus	0-8
11118199-2	2000	The therapeutically important K(+) channel openers (e.g. pinacidil, cromakalim, nicorandil) act specifically on the SUR2 muscle isoforms but, except for diazoxide, remain ineffective on the SUR1 neuronal/pancreatic isoform.	Cromakalim	68-78	ATP binding cassette subfamily C member 9	Homo sapiens	116-120
10780981-7	2000	The cyclic AMP-dependent protein kinase A inhibitor Rp-cyclic AMPS, but not the cyclic GMP antagonist Rp-8-Bromo-cyclic GMPS, effectively inhibited the enhancing effects 1 M 17beta-estradiol had on the relaxation responses of levcromakalim and sodium nitroprusside.	Cromakalim	226-239	adenylosuccinate lyase	Homo sapiens	62-66
9890402-10	1999	Increased plasma ANP levels, an index of cardiac filling pressure after induction of acute ischemic heart failure, were decreased significantly by cromakalim and tended to decrease by nicorandil or nitroglycerin.	Cromakalim	147-157	natriuretic peptide A	Canis lupus familiaris	17-20
10422791-7	1999	Indomethacin increased myeloperoxidase activity in the gastric mucosa, an effect which was reversed by cromakalim and diazoxide.	Cromakalim	103-113	myeloperoxidase	Rattus norvegicus	23-38
10422791-10	1999	The effects of cromakalim and diazoxide on mucosal myeloperoxidase activity, neutrophil infiltration and gastric injury correlated with each other.	Cromakalim	15-25	myeloperoxidase	Rattus norvegicus	51-66
10358118-3	1999	Here we report the effects of levcromakalim (LCRK, a channel opener) and glibenclamide (GBC, a blocker) on membrane potential, whole-cell current and the cytoplasmic Ca2+ concentration of renin-secreting cells (RSC).	Cromakalim	30-43	renin	Rattus norvegicus	188-193
9869259-17	1998	These results suggest that pretreatments with KRN4884 and levcromakalim are more effective on ET-1-induced electrocardiogram changes than those with nilvadipine and propranolol.	Cromakalim	58-71	endothelin 1	Rattus norvegicus	94-98
9479020-9	1998	Finally, the dependence on calcium of the cromakalim-induced stimulation of renin was examined.	Cromakalim	42-52	renin	Rattus norvegicus	76-81
9592027-11	1998	infusion of cromakalim (0.1 microg kg(-1) min(-1)) also augmented the responses to VIP, CGRP and adenosine, but not to acetylcholine, whereas a single bolus i.v.	Cromakalim	12-22	vasoactive intestinal peptide	Rattus norvegicus	83-86
9592027-11	1998	infusion of cromakalim (0.1 microg kg(-1) min(-1)) also augmented the responses to VIP, CGRP and adenosine, but not to acetylcholine, whereas a single bolus i.v.	Cromakalim	12-22	calcitonin-related polypeptide alpha	Rattus norvegicus	88-92
9435598-5	1997	Cromakalim, a KATP agonist, produced dilation that was attenuated by FPI and partially restored by BQ-123, an ET-1 antagonist (11 +/- 1 and 23 +/- 2 vs. 2 +/- 1 and 4 +/- 1 vs. 8 +/- 1 and 17 +/- 2% for responses to 10(-8) and 10(-6) M cromakalim before FPI, after FPI, and after FPI with BQ-123, respectively).	Cromakalim	0-10	endothelin 1	Homo sapiens	110-114
9439778-2	1997	Pinacidil, lemakalim, diazoxide and a new compound, BPDZ44, had an inhibitory effect on the electrical activity of CA1 pyramidal cells.	Cromakalim	11-20	carbonic anhydrase 1	Rattus norvegicus	115-118
9105697-14	1997	Addition of 100 microM levcromakalim after the NDP-induced current had peaked activated a further outward current which was larger than that recorded in the absence of NDPs.	Cromakalim	23-36	norrin cystine knot growth factor NDP	Sus scrofa	47-50
9234831-6	1997	Clotrimazole, an imidazole that inhibits CYP by binding to the heme moiety, attenuated ACh, histamine, and cromakalim but not sodium nitroprusside-mediated vasodilator responses.	Cromakalim	107-117	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	41-44
9145771-3	1997	From these shifts pK(B) were calculated to estimate the potency of these compounds as levcromakalim antagonists.	Cromakalim	86-99	AKT serine/threonine kinase 1	Sus scrofa	18-22
9030898-0	1997	Cromakalim blocks the purinergic response evoked in rat vas deferens by single-pulse electrical stimulation.	Cromakalim	0-10	arginine vasopressin	Rattus norvegicus	56-59
9113380-8	1997	IK(ATP) induced by either KRN4884 (0.3 microM) or cromakalim (10 microM) was significantly enhanced by the additional application of a NO donor (+/-)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide (NOR3, 0.1 and 1 mM).	Cromakalim	50-60	nuclear receptor subfamily 4 group A member 3	Homo sapiens	204-219
8928882-6	1996	Ectosolic and cytosolic 5"-nucleotidase activity increased in the ischemic preconditioning group compared with that in the control group; this preconditioning-induced increase in 5"-nucleotidase activity was blunted by glibenclamide (n = 5) and mimicked by cromakalim (n = 5) and nicorandil (n = 5).	Cromakalim	257-267	5'-nucleotidase ecto	Canis lupus familiaris	24-39
9023770-8	1997	The pharmacological properties of Kir6.2-SUR1 currents resembled those of native beta-cell ATP-sensitive K+ channel currents (KATP currents): the currents were > 90% blocked by tolbutamide (500 microM), meglitinide (10 microM) or glibenclamide (100 nM), and activated 1.8-fold by diazoxide (340 microM), 1.4-fold by pinacidil (1 mM) and unaffected by cromakalim (0.5 mM).	Cromakalim	354-364	ATP-binding cassette sub-family C member 8	Xenopus laevis	41-45
8761850-7	1996	In both nitrate-tolerant and nontolerant coronary arteries, glibenclamide (GLI 10(-6) M), a selective KATP channel blocker, caused a parallel rightward shift in the concentration-response curve to cromakalim, but had no effect on responses to NTG or SNP.	Cromakalim	197-207	GLI family zinc finger 1	Homo sapiens	75-78
8928882-6	1996	Ectosolic and cytosolic 5"-nucleotidase activity increased in the ischemic preconditioning group compared with that in the control group; this preconditioning-induced increase in 5"-nucleotidase activity was blunted by glibenclamide (n = 5) and mimicked by cromakalim (n = 5) and nicorandil (n = 5).	Cromakalim	257-267	5'-nucleotidase ecto	Canis lupus familiaris	179-194
8871136-4	1996	Moreover, on guinea pig isolated main bronchi, SCA40 can exert a preventive effect on contractions induced by acetylcholine, neurokinin A or capsaicin, that is, it shifts to the right the concentration-effect curves of these substances, whereas cromakalim has no such effect.	Cromakalim	245-255	coiled-coil domain containing 88C	Homo sapiens	47-52
8720582-8	1996	The same results were found with other agonists of 5-HT1A receptors (lesopitron, buspirone and tandospirone): gliquidone inhibited whereas cromakalim increased their antinociceptive effects.	Cromakalim	139-149	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	51-57
8605948-4	1995	When caffeine was applied at the beginning of this fade of levcromakalim-induced relaxation in Rb-PSS its contractile effect was potentiated.	Cromakalim	59-72	PSS	Homo sapiens	98-101
8656645-5	1996	ET-1 also attenuated the cromakalim-induced decreases in APD and DT.	Cromakalim	25-35	endothelin-1	Cavia porcellus	0-4
7522965-0	1994	Assessment of ability of levcromakalim and sodium nitroprusside to reverse the cardiovascular effects of nitric oxide synthase inhibition in the anaesthetised pig.	Cromakalim	25-38	nitric oxide synthase 2	Sus scrofa	105-126
7734660-6	1995	However, in contrast to what would be expected from KATP blockade by vasopressin, rings preconstricted with vasopressin were more sensitive to the relaxant action of lemakalim, compared to phenylephrine preconstricted vessels (log[EC50] of -7.82 +/- 0.01 and -7.10 +/- 0.02, respectively, p < 0.05).	Cromakalim	166-175	arginine vasopressin	Rattus norvegicus	108-119
7734660-8	1995	When aortic rings were pretreated with lemakalim (0.1 microM), the maximum active tension induced by vasopressin was reduced (2.68 +/- 0.23 in control conditions vs. 0.62 +/- 0.08 g on pretreated vessels, p < 0.001), whereas that by phenylephrine was slightly increased.	Cromakalim	39-48	arginine vasopressin	Rattus norvegicus	101-112
7734660-9	1995	In order to explain the stronger relaxant action of lemakalim against vasopressin-induced constriction, the contribution of calcium influx through L-type calcium channels in the constriction of aortic rings to vasopressin and phenylephrine was compared.	Cromakalim	52-61	arginine vasopressin	Rattus norvegicus	70-81
7834212-9	1994	and the CGRP-induced hyperpolarization were inhibited by the CGRP receptor antagonist, CGRP(8-37) (0.3-3 microM) which did not affect the hyperpolarization produced by the KATP channel opener, cromakalim (0.3 microM).	Cromakalim	193-203	calcitonin related polypeptide alpha	Homo sapiens	8-12
7834212-9	1994	and the CGRP-induced hyperpolarization were inhibited by the CGRP receptor antagonist, CGRP(8-37) (0.3-3 microM) which did not affect the hyperpolarization produced by the KATP channel opener, cromakalim (0.3 microM).	Cromakalim	193-203	calcitonin related polypeptide alpha	Homo sapiens	61-65
7834212-9	1994	and the CGRP-induced hyperpolarization were inhibited by the CGRP receptor antagonist, CGRP(8-37) (0.3-3 microM) which did not affect the hyperpolarization produced by the KATP channel opener, cromakalim (0.3 microM).	Cromakalim	193-203	calcitonin related polypeptide alpha	Homo sapiens	61-65
7875541-7	1994	Cromakalim at 10(-5) M and nitroglycerin at 10(-7) M completely eliminated 3,4-DAP-induced rythmic contractions in all preparations.	Cromakalim	0-10	death associated protein	Homo sapiens	79-82
8058589-0	1994	Effect of cromakalim on spontaneous activity of castrated rat vas deferens.	Cromakalim	10-20	arginine vasopressin	Rattus norvegicus	62-65
8026555-2	1994	K+ channel openers, either BRL38227 or diazoxide, caused dose-dependent and complete relaxation of isolated arteries precontracted by neuropeptide Y.	Cromakalim	27-35	neuropeptide Y	Oryctolagus cuniculus	134-148
8026555-5	1994	In vivo, the pressor responses produced by neuropeptide Y were significantly inhibited by pretreatment with BRL38227 in anesthetized rats.	Cromakalim	108-116	neuropeptide Y	Rattus norvegicus	43-57
8185413-7	1993	The combination of cromakalim and nitroglycerin relaxed the 10(-8) M endothelin-1- and 40 mM KCl-induced contractions in a concentration-dependent manner.	Cromakalim	19-29	endothelin 1	Homo sapiens	69-81
8185413-9	1993	The maximum relaxation of the combination of cromakalim (3 x 10(-5) M) and nitroglycerin (3 x 10(-6) M) was complete for the endothelin-1-induced contraction but a relaxation of 77.8% was obtained for the 40 mM KCl-induced contraction, i.e. the relaxant effects using this combination were greater than those by cromakalim (3 x 10(-5) M) alone.	Cromakalim	45-55	endothelin 1	Homo sapiens	125-137
8185413-2	1993	KRN2391, nitroglycerin and cromakalim concentration-dependently inhibited the 10(-8) M endothelin-1-induced contraction, but less potently inhibited the 40 mM KCl-induced contraction.	Cromakalim	27-37	endothelin 1	Homo sapiens	87-99
8185413-5	1993	Cromakalim and nifedipine, both at 3 x 10(-5) M, produced 83.9% and 73.3% of the complete relaxation of the endothelin-1-induced contraction, respectively.	Cromakalim	0-10	endothelin 1	Homo sapiens	108-120
7687721-5	1993	Second, in aortic rings tonically contracted by 1 microM norepinephrine (NE) in the presence of 1 microM nifedipine, i.e., in rings contracted mainly owing to NE-stimulated Ca2+ entry through receptor-operated channels, (-)-cromakalim induced relaxation with an EC50 of 0.68 microM and exhibited a 191-fold higher potency than the (+)-enantiomer.	Cromakalim	224-234	carbonic anhydrase 2	Oryctolagus cuniculus	173-176
8242233-4	1993	Application of 10 microM levcromakalim ((-)-Ckm) to single cells held with pipettes containing 1 mM GDP induced a K-current (IK(Ckm)) which occurred in addition to the current caused by GDP alone (IK(GDP)) and averaged 135 pA at -37 mV.	Cromakalim	25-38	creatine kinase M-type	Oryctolagus cuniculus	44-47
8242233-4	1993	Application of 10 microM levcromakalim ((-)-Ckm) to single cells held with pipettes containing 1 mM GDP induced a K-current (IK(Ckm)) which occurred in addition to the current caused by GDP alone (IK(GDP)) and averaged 135 pA at -37 mV.	Cromakalim	25-38	creatine kinase M-type	Oryctolagus cuniculus	128-131
2084109-4	1990	Under normoxia, cromakalim infusion (2 micrograms kg-1 min-1 for 30 min) progressively decreased diastolic systemic arterial pressure (DBP, 30%) and total systemic vascular resistance (TSVR, 54%).	Cromakalim	16-26	D-box binding PAR bZIP transcription factor	Canis lupus familiaris	135-138
8477154-0	1993	Effect of cromakalim on KCl-, noradrenaline- and angiotensin II-induced contractions in the rat pulmonary artery.	Cromakalim	10-20	angiotensinogen	Rattus norvegicus	49-63
8477154-11	1993	Contractions induced by NA and AII in the presence of tetraethylammonium (TEA, 10 mM) were also depressed by cromakalim.	Cromakalim	109-119	angiotensinogen	Rattus norvegicus	31-34
7509930-5	1993	However, levcromakalim significantly inhibited 125I-ET-1 binding (maximum binding 49 4/- 9%; p = 0.04), whereas the inactive isomer, D-cromakalim, had no effect.	Cromakalim	9-22	endothelin 1	Rattus norvegicus	52-56
1422579-9	1992	A subcontractile concentration of ET-1 (0.1 nM) prevented the inhibitory effects of low concentrations of BRL-38227 (0.06-0.1 microM) on KCl responses, but failed to modify those to RP-49356, pinacidil or high concentrations of BRL-38227 (0.3-3.0 microM).	Cromakalim	106-115	endothelin 1	Rattus norvegicus	34-38
1422579-9	1992	A subcontractile concentration of ET-1 (0.1 nM) prevented the inhibitory effects of low concentrations of BRL-38227 (0.06-0.1 microM) on KCl responses, but failed to modify those to RP-49356, pinacidil or high concentrations of BRL-38227 (0.3-3.0 microM).	Cromakalim	228-237	endothelin 1	Rattus norvegicus	34-38
1422579-34	1992	In conclusion, ET-1 selectively attenuated the vasorelaxant effects of the potassium channel opener,BRL-38227 and other substituted benzopyrans.	Cromakalim	100-109	endothelin 1	Rattus norvegicus	15-19
1376359-7	1992	Cromakalim and nicardipine virtually abolished ET-1-induced contraction.	Cromakalim	0-10	endothelin-1	Cavia porcellus	47-51
1534504-2	1992	Cromakalim (0.01-30 microM) and sodium nitroprusside (SNP, 0.01-100 microM) were tested for their ability to relax a number of pre-contracted small arteries (approximate diameter 200-700 microM at 100 mmHg) from the rat, rabbit and guinea-pig.	Cromakalim	0-10	neurogenin 3	Rattus norvegicus	109-114
1725890-6	1991	During angiotensin II infusion, TPR was also lower on both doses of cromakalim (p less than 0.05).	Cromakalim	68-78	angiotensinogen	Homo sapiens	7-21
1725890-9	1991	The potassium channel activator, cromakalim, therefore antagonized the changes in TPR induced by norepinephrine, angiotensin II, and isoproterenol, but did not interfere with the cardiac responses, suggesting selectivity for arterial smooth muscle.	Cromakalim	33-43	angiotensinogen	Homo sapiens	113-127
1735599-5	1992	Responses of rings to endothelin-1 were profoundly reduced in Ca(2+)-free medium, but less inhibition was obtained after incubation with nicardipine (up to 1 microM) and/or nickel (up to 0.5 mM), phorbol (up to 0.3 microM), staurosporine (up to 10 nM), or cromakalim (3 microM).	Cromakalim	256-266	endothelin 1	Rattus norvegicus	22-34
1786804-0	1991	Inhibition by glibenclamide of the effects of cromakalim on responses of rat vas deferens to naphazoline.	Cromakalim	46-56	arginine vasopressin	Rattus norvegicus	77-80
1786804-1	1991	Cromakalim has been shown to inhibit naphazoline-induced contractions and spontaneous activity induced by exposure to naphazoline in the rat isolated vas deferens.	Cromakalim	0-10	arginine vasopressin	Rattus norvegicus	150-153
2405151-11	1990	The pressor effects of ET-1 were reduced by diltiazem, nitrendipine, verapamil or cromakalim and unchanged after BW 755c, desipramine, enalapril, indomethacin, methysergide, phentolamine or SK&F 100273.	Cromakalim	82-92	endothelin 1	Rattus norvegicus	23-27
2149290-8	1990	Tetrabutylammonium (TBA), a nonselective K+ channel blocker, or glibenclamide, a supposed adenosine 5"-triphosphate (ATP)-sensitive K+ channel blocker, abolished the reduction of [Ca2+]i caused by the three K+ channel openers and the relaxant effect of cromakalim, whereas they only slightly attenuated the relaxant effects of pinacidil and nicorandil.	Cromakalim	253-263	carbonic anhydrase 2	Canis lupus familiaris	180-183
2149290-12	1990	The [Ca2+]i-force relationship in the presence of cromakalim was not distinguishable from that of control.	Cromakalim	50-60	carbonic anhydrase 2	Canis lupus familiaris	5-8
1698266-4	1990	In patch-clamped cells, pinacidil (1 mumol/l) and cromakalim (1 mumol/l) elicited outward currents carried by K+ and significantly prolonged the Ca2(+)-dependent K+ currents induced by bradykinin and ATP.	Cromakalim	50-60	kininogen 1	Homo sapiens	185-195
2405151-13	1990	infusion of ET-1 (0.25 nmol/kg/min/60 min) was also antagonized markedly by nitrendipine and cromakalim.	Cromakalim	93-103	endothelin 1	Rattus norvegicus	12-16
2405151-17	1990	In aortic rings, the sustained contractile effects of ET-1 (3.2 nM) were reduced moderately by nitrendipine (50 nM) and markedly by cromakalim (0.8 microM).	Cromakalim	132-142	endothelin 1	Rattus norvegicus	54-58
34816764-9	2022	The Kir6.1 smooth muscle knockout mouse was protected from both GTN and levcromakalim induced hypersensitivity, and their arteries had impaired dilatory response to the latter.	Cromakalim	72-85	potassium inwardly-rectifying channel, subfamily J, member 8	Mus musculus	4-10
34407650-0	2021	CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine.	Cromakalim	84-97	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	0-4
33100270-9	2021	Patch-clamp studies detected cromakalim-elicited unitary K+ currents in cell-attached patches of LMCs with a single-channel conductance of 46.4 pS, which is a property consistent with Kir6.1/6.2 tetrameric channels.	Cromakalim	29-39	potassium inwardly-rectifying channel, subfamily J, member 8	Rattus norvegicus	184-190
35562524-5	2022	Here, we present cryo-EM structures of SUR2A and SUR2B subunits in complex with Mg-nucleotides and P1075 or levcromakalim, two chemically distinct KATP openers that are specific to SUR2.	Cromakalim	108-121	ATP binding cassette subfamily C member 9	Homo sapiens	181-185
2586636-0	1989	Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro.	Cromakalim	11-21	carbonic anhydrase 3	Cavia porcellus	63-66
2586636-1	1989	The action of the potassium channel activator, cromakalim (BRL 34915), on membrane potential, input resistance and current-voltage-relationship of CA3 neurons in a slice preparation of the guinea-pig hippocampus was investigated by means of intracellular recordings.	Cromakalim	47-57	carbonic anhydrase 3	Cavia porcellus	147-150