PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7904476-2	1994	Among MDR reversing agents, phenothiazines (PTZs) and related compounds may sensitize MDR by interacting with a specific binding site(s) on P-gp and by other mechanisms.	Phenothiazines	28-42	ATP binding cassette subfamily B member 1	Homo sapiens	140-144
7904476-2	1994	Among MDR reversing agents, phenothiazines (PTZs) and related compounds may sensitize MDR by interacting with a specific binding site(s) on P-gp and by other mechanisms.	Phenothiazines	44-48	ATP binding cassette subfamily B member 1	Homo sapiens	140-144
7904476-8	1994	While PTZs and related compounds were potent inhibitors of [125I]NAPS binding to P-gp, most of them enhanced the binding of [125I]AAP significantly.	Phenothiazines	6-10	ATP binding cassette subfamily B member 1	Homo sapiens	81-85
1356900-2	1992	In addition to transporting anticancer drugs, P-glycoprotein has been reported to extrude a variety of lipophilic drugs, such as calcium channel blockers, phenothiazines, cyclosporines etc.	Phenothiazines	155-169	ATP binding cassette subfamily B member 1	Homo sapiens	46-60
1417975-0	1992	Phenothiazines inhibit acetylcholinesterase by concentration-dependent-type kinetics.	Phenothiazines	0-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-43
1417975-6	1992	Results support the notion that phenothiazines may interact with AChE both as monomers and micellar aggregates, producing different inhibitory effects.	Phenothiazines	32-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-69
8302284-1	1994	P-type Ca2+ channels in cerebellar Purkinje neurons and N-type Ca2+ channels in sympathetic neurons were found to be inhibited by D2 dopamine receptor antagonists with diverse structures, including phenothiazines (chlorpromazine and thioridazine), diphenylbutylpiperidines (fluspirilene and pimozide), butyrophenones (haloperidol and spiperone), and a piperazine (fluphenazine).	Phenothiazines	198-212	dopamine receptor D2	Homo sapiens	130-150
1346493-2	1992	We have used one class of drug, the phenothiazines, to study the structural features required for optimum interference with the function of P-gp.	Phenothiazines	36-50	ATP binding cassette subfamily B member 1	Homo sapiens	140-144
1511289-10	1992	The phenothiazines, chlorpromazine and fluphenazine, bind to both D1 and D2 dopamine receptors and effectively compete with [3H]TAM for binding at the AEBS.	Phenothiazines	4-18	dopamine receptor D2	Rattus norvegicus	66-94
2575143-0	1989	Thermodynamics of the binding of phenothiazines to human plasma, human serum albumin and alpha 1-acid glycoprotein: a calorimetric study.	Phenothiazines	33-47	albumin	Homo sapiens	71-84
1683624-4	1991	The analysis of the publications devoted to this point indicates that several drugs are actually considered as potent disinhibitors (i.e. active on negative symptoms of schizophrenia): Phenothiazines: As shown in the controlled studies by Itil (1971), Poirier-Littre (1988), fluphenazine and pipotiazine improve the BPRS anergia factor and the SANS score.	Phenothiazines	185-199	USH1 protein network component sans	Homo sapiens	344-348
2159347-6	1990	Other calcium antagonists such as diltiazem, nifedipine, nitrendipine or amphiphilic drugs such as phenothiazines and propranolol also enhanced HDL3 uptake by Hep G2 cells.	Phenothiazines	99-113	HDL3	Homo sapiens	144-148
2310408-1	1990	The phenothiazines chlorpromazine and perphenazine and the butyrophenone haloperidol were shown to be reversible inhibitors of glutamate dehydrogenase (GDH).	Phenothiazines	4-18	glutamate dehydrogenase 1	Homo sapiens	127-150
2310408-1	1990	The phenothiazines chlorpromazine and perphenazine and the butyrophenone haloperidol were shown to be reversible inhibitors of glutamate dehydrogenase (GDH).	Phenothiazines	4-18	glutamate dehydrogenase 1	Homo sapiens	152-155
33807495-0	2021	A Small Molecule Targeting Human MEK1/2 Enhances ERK and p38 Phosphorylation under Oxidative Stress or with Phenothiazines.	Phenothiazines	108-122	mitogen-activated protein kinase kinase 1	Homo sapiens	33-39
33807495-0	2021	A Small Molecule Targeting Human MEK1/2 Enhances ERK and p38 Phosphorylation under Oxidative Stress or with Phenothiazines.	Phenothiazines	108-122	mitogen-activated protein kinase 1	Homo sapiens	49-52
33807495-0	2021	A Small Molecule Targeting Human MEK1/2 Enhances ERK and p38 Phosphorylation under Oxidative Stress or with Phenothiazines.	Phenothiazines	108-122	mitogen-activated protein kinase 14	Homo sapiens	57-60
33807495-5	2021	In line with the previous results in fission yeast, the phosphorylation of the MAPKs ERK and p38 increased substantially more with the combination treatment than by H2O2 or phenothiazines, whereas INR119 alone did not affect phosphorylation.	Phenothiazines	173-187	mitogen-activated protein kinase 1	Homo sapiens	85-88
33807495-5	2021	In line with the previous results in fission yeast, the phosphorylation of the MAPKs ERK and p38 increased substantially more with the combination treatment than by H2O2 or phenothiazines, whereas INR119 alone did not affect phosphorylation.	Phenothiazines	173-187	mitogen-activated protein kinase 14	Homo sapiens	93-96
34587361-8	2021	On the other hand, Chlorpromazine belonging to phenothiazines class has the least potential to suppress YAP via proteasomal degradation (cell viability value of <20% at 40 microM).	Phenothiazines	47-61	Yes1 associated transcriptional regulator	Homo sapiens	104-107
35617282-8	2022	We reasoned that these activities remain combined in PTZ, which were the starting point for PP2A activator development, while several PTZ are known CaM inhibitors.	Phenothiazines	134-137	calmodulin 1	Homo sapiens	148-151
35617282-11	2022	Like DT-061, both PTZ potently decreased c-MYC levels, a hallmark of PP2A activation.	Phenothiazines	18-21	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	41-46
35617282-13	2022	While our study is limited, our results suggest that improved PTZ derivatives that retain both, their CaM inhibitory and PP2A activating properties, but have lost their neurological side-effects, may be interesting to pursue further as anti-cancer agents.	Phenothiazines	62-65	calmodulin 1	Homo sapiens	102-105
35617282-13	2022	While our study is limited, our results suggest that improved PTZ derivatives that retain both, their CaM inhibitory and PP2A activating properties, but have lost their neurological side-effects, may be interesting to pursue further as anti-cancer agents.	Phenothiazines	62-65	protein phosphatase 2 phosphatase activator	Homo sapiens	121-125
1859207-4	1991	Inhibitors of phospholipase A2, including a variety of phenothiazines, dibucaine, imipramine, and verapamil, inhibited in vitro microsomal lipid peroxidation in response to TCDD administration.	Phenothiazines	55-69	phospholipase A2 group IB	Rattus norvegicus	14-30
35617282-0	2022	Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells.	Phenothiazines	13-27	calmodulin 1	Homo sapiens	53-63
35617282-0	2022	Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells.	Phenothiazines	13-27	protein phosphatase 2 phosphatase activator	Homo sapiens	79-83
2713218-2	1989	Since, in man, plasma AGP level determines the protein binding of many important drugs (e.g. narcotic analgesics, phenothiazines, antiarrhythmics, calcium channel blockers) likely to be given to patients who will be treated with TNF, it is important to determine if TNF treatment of humans causes a similar increase in AGP concentration and drug binding.	Phenothiazines	114-128	orosomucoid 1	Rattus norvegicus	22-25
2474349-6	1989	The putative calmodulin antagonists, chlorpromazine, promethazine, thioridazine (phenothiazines) and W-7 (a naphthalene sulphonamide) all inhibited histamine release in the presence of divalent cations in both untreated cells and in RPMC depleted of their intracellular calcium.	Phenothiazines	81-95	calmodulin 1	Rattus norvegicus	13-23
3134891-6	1988	However, in contrast to the reversible binding of most phenothiazines to calmodulin, phenoxybenzamine bound to calmodulin irreversibly.	Phenothiazines	55-69	calmodulin 1	Homo sapiens	73-83
3134891-2	1988	This interaction was found to be similar in some respects to the interaction between phenothiazines and calmodulin.	Phenothiazines	85-99	calmodulin 1	Homo sapiens	104-114
2448600-2	1988	Micromolar concentrations of the phenothiazines, fluphenazine and trifluoperazine, and haloperidol, a non-phenothiazine antipsychotic and calmodulin antagonist, selectively inhibited the Ca-activated K channels.	Phenothiazines	33-47	calmodulin 1	Rattus norvegicus	138-148
3383286-1	1988	Plasmid pBR 322 was subjected to UV-A irradiation in the presence of photosensitive drugs, i.e., phenothiazines [chlorpromazine hydrochloride (CPZ), promethazine hydrochloride (PMZ) and mequitazine (MQZ)], benzothiadiazines [penflutizide (PFZ), hydrochlorothiazide (HCT) and methyclothiazide (MCT)] and afloqualone (AQ).	Phenothiazines	97-111	translocator protein	Homo sapiens	8-11
3499164-0	1987	Do phenothiazines contribute to tumour regressions in lymphokine-activated killer cell/interleukin-2 treatments of renal cell cancer?	Phenothiazines	3-17	interleukin 2	Homo sapiens	87-100
2449225-1	1987	The interaction of several phenothiazines, benzodiazepines, butyrophenones, polycyclic neuroleptics and tricyclic antidepressants with calmodulin and troponin C was investigated using the fluorescent dye 3,3"-dipropylthiocarbocyanine iodide.	Phenothiazines	27-41	calmodulin 1	Homo sapiens	135-145
3578141-3	1987	Phenothiazines have been demonstrated to cause elevated serum prolactin levels.	Phenothiazines	0-14	prolactin	Homo sapiens	62-71
3628966-7	1987	The ranking of phenothiazines, in terms of cytotoxic activity corresponds with that reported in the literature for calmodulin-inhibiting potency.	Phenothiazines	15-29	calmodulin 1	Homo sapiens	115-125
3628966-8	1987	It is conjectured that the cytotoxic effect of phenothiazines could be wholly or partially explained on the basis of their interaction with calmodulin.	Phenothiazines	47-61	calmodulin 1	Homo sapiens	140-150
3600606-6	1987	In as much as fragment (82-93) of CaM is a plausible candidate receptor site for phenothiazines, these results imply that two such compounds should be endowed with a significantly greater anti-CaM activity than TFP itself.	Phenothiazines	81-95	calmodulin 1	Homo sapiens	34-37
3600606-6	1987	In as much as fragment (82-93) of CaM is a plausible candidate receptor site for phenothiazines, these results imply that two such compounds should be endowed with a significantly greater anti-CaM activity than TFP itself.	Phenothiazines	81-95	calmodulin 1	Homo sapiens	193-196
3820316-5	1986	This loss of membrane integrity was calmodulin-dependent as demonstrated by the following: phenothiazines (trifluoperazine greater than chlorpromazine greater than promethazine) and structurally dissimilar calmodulin-inhibitors prevented the formation of sarcolemmal defects at concentrations similar to those known to inhibit calmodulin; phenothiazines and calcium demonstrated a competitive interaction with respect to this effect on membrane integrity.	Phenothiazines	91-105	calmodulin 1	Homo sapiens	36-46
3037792-2	1987	As compared with butyrophenones, phenothiazines were shown to be more effective inhibitors of calmodulin-dependent activation of the phosphodiesterase.	Phenothiazines	33-47	calmodulin 1	Homo sapiens	94-104
3037792-3	1987	Phenothiazines inhibited similarly the effect of calmodulin on activity of kinase phosphorylase, whereas they did not affect the Ca2+-dependent activity of kinase phosphorylase.	Phenothiazines	0-14	calmodulin 1	Homo sapiens	49-59
3037792-5	1987	The data obtained suggest that dissimilar effect of phenothiazines on calmodulin-dependent regulation of kinase phosphorylase and phosphodiesterase, carried out using dissimilar mechanisms, required an extreme caution in evaluation of physiological and biochemical experiments, where these drugs were used as means for study of calmodulin functions in biological processes.	Phenothiazines	52-66	calmodulin 1	Homo sapiens	70-80
3037792-5	1987	The data obtained suggest that dissimilar effect of phenothiazines on calmodulin-dependent regulation of kinase phosphorylase and phosphodiesterase, carried out using dissimilar mechanisms, required an extreme caution in evaluation of physiological and biochemical experiments, where these drugs were used as means for study of calmodulin functions in biological processes.	Phenothiazines	52-66	calmodulin 1	Homo sapiens	328-338
2449186-4	1987	2) Even within one and the same pharmacological class (e.g. phenothiazines) the relative affinities for CaM and TnC varied considerably, trifluoperazine (TFP) or levomepromazine (LMP) showing low or no CaM specificity, methophenazine (MP) on the other hand being highly selective for CaM by a factor of more than 200.	Phenothiazines	60-74	calmodulin 1	Homo sapiens	104-107
2449186-4	1987	2) Even within one and the same pharmacological class (e.g. phenothiazines) the relative affinities for CaM and TnC varied considerably, trifluoperazine (TFP) or levomepromazine (LMP) showing low or no CaM specificity, methophenazine (MP) on the other hand being highly selective for CaM by a factor of more than 200.	Phenothiazines	60-74	tenascin C	Homo sapiens	112-115
3820316-5	1986	This loss of membrane integrity was calmodulin-dependent as demonstrated by the following: phenothiazines (trifluoperazine greater than chlorpromazine greater than promethazine) and structurally dissimilar calmodulin-inhibitors prevented the formation of sarcolemmal defects at concentrations similar to those known to inhibit calmodulin; phenothiazines and calcium demonstrated a competitive interaction with respect to this effect on membrane integrity.	Phenothiazines	339-353	calmodulin 1	Homo sapiens	36-46
3030874-1	1986	Unstimulated (basal) as well as luteinizing hormone (LH)-promoted progesterone production in collagenase-dispersed hen granulosa cells was inhibited in a dose-related manner by two phenothiazines, trifluoperazine (TFP) and chlorpromazine (CP), both of which are known calmodulin antagonists.	Phenothiazines	181-195	calmodulin 2	Gallus gallus	268-278
2876734-2	1986	There has been found the parameter-relaxation index-the change of which under the effect of phenothiazines (10(-5) M in all the cases) made use of significantly correlates with the constants, which reflect the similarity of given agents with calmodulin.	Phenothiazines	92-106	calmodulin 1	Rattus norvegicus	242-252
3030874-6	1986	The results are discussed in relation to calmodulin- and non-calmodulin-mediated actions of phenothiazines.	Phenothiazines	92-106	calmodulin 2	Gallus gallus	41-51
3030874-6	1986	The results are discussed in relation to calmodulin- and non-calmodulin-mediated actions of phenothiazines.	Phenothiazines	92-106	calmodulin 2	Gallus gallus	61-71
2423656-3	1986	The discovery that drugs such as phenothiazines antagonize the action of calmodulin led to the study of these antagonists against tumor cells.	Phenothiazines	33-47	calmodulin 1	Homo sapiens	73-83
3717195-1	1986	Although several phenothiazines are known to stimulate prolactin (PRL) secretion, only chlorpromazine is in general use for this purpose in humans.	Phenothiazines	17-31	prolactin	Homo sapiens	55-64
3717195-1	1986	Although several phenothiazines are known to stimulate prolactin (PRL) secretion, only chlorpromazine is in general use for this purpose in humans.	Phenothiazines	17-31	prolactin	Homo sapiens	66-69
4072731-7	1985	Patients on phenothiazines had higher PRL and lower TSH levels than those on other drugs or without medication, but there was no significant difference in the mean increment by ECT.	Phenothiazines	12-26	prolactin	Homo sapiens	38-41
3702854-4	1986	The ordering of interaction energies of the four investigated phenothiazines parallels the ordering of their experimentally measured affinities for calmodulin, with a maximum affinity for trifluoperazine.	Phenothiazines	62-76	calmodulin 1	Homo sapiens	148-158
4062971-6	1985	Calmodulin (CaM), purified from L1210 cells by preparative polyacrylamide gel electrophoresis, had sensitivity to inhibition by phenothiazines similar to that reported for CaM prepared from brain.	Phenothiazines	128-142	calmodulin 2	Mus musculus	0-10
4062971-6	1985	Calmodulin (CaM), purified from L1210 cells by preparative polyacrylamide gel electrophoresis, had sensitivity to inhibition by phenothiazines similar to that reported for CaM prepared from brain.	Phenothiazines	128-142	calmodulin 2	Mus musculus	12-15
4062971-11	1985	These studies add pharmacological support for CaM being a potential intracellular target for the antiproliferative effect of the phenothiazines.	Phenothiazines	129-143	calmodulin 2	Mus musculus	46-49
3757154-0	1986	The antiproliferative properties of tamoxifen and phenothiazines may be mediated by a unique histamine receptor (?H3) distinct from the calmodulin-binding site.	Phenothiazines	50-64	H3 clustered histone 14	Homo sapiens	113-116
3757154-3	1986	However, at an in vitro concentration of 1 X 10(-6) M, the antiproliferative effects of DPPE and several phenothiazines, which also compete for binding to AEBS/?H3, are about equal; this suggests that affinity for AEBS/?H3 rather than that for the calmodulin-binding site may correlate with clinically relevant antigrowth effects of these compounds.	Phenothiazines	105-119	H3 clustered histone 14	Homo sapiens	160-163
3757154-3	1986	However, at an in vitro concentration of 1 X 10(-6) M, the antiproliferative effects of DPPE and several phenothiazines, which also compete for binding to AEBS/?H3, are about equal; this suggests that affinity for AEBS/?H3 rather than that for the calmodulin-binding site may correlate with clinically relevant antigrowth effects of these compounds.	Phenothiazines	105-119	H3 clustered histone 14	Homo sapiens	219-222
2986673-13	1985	U.S.A. 78, 6793-6797] that indicated a subclass of calcium-modulated proteins bound phenothiazines in a calcium-dependent manner, demonstrate that the interaction between phenothiazines and calmodulin is more complex than previously assumed, and suggest that extended regions of the calmodulin molecule capable of forming the appropriate conformation are required for specific, high-affinity, calcium-dependent drug binding activity.	Phenothiazines	171-185	calmodulin	Bos taurus	190-200
2860989-3	1985	Mean apolipoproteins C-II and C-III and very low-density lipoprotein cholesterol levels in the patients receiving phenothiazines were higher than levels in the patients receiving butyrophenone or in the controls.	Phenothiazines	114-128	apolipoprotein E	Homo sapiens	5-20
4096539-4	1985	Phenothiazines (trifluoperazine and chlorpromazine), mepacrine, propranolol, and colchicine inhibited the effect of the purified epidermal calmodulin on the calmodulin-deficient phosphodiesterase of bovine heart.	Phenothiazines	0-14	calmodulin-3	Sus scrofa	139-149
4096539-4	1985	Phenothiazines (trifluoperazine and chlorpromazine), mepacrine, propranolol, and colchicine inhibited the effect of the purified epidermal calmodulin on the calmodulin-deficient phosphodiesterase of bovine heart.	Phenothiazines	0-14	calmodulin-3	Sus scrofa	157-167
2861818-6	1985	It is proposed that in the interaction of phenothiazine drugs with ceruloplasmin, charge transfer complexes between the phenothiazines and Cu2+ of the enzyme, are involved.	Phenothiazines	120-134	ceruloplasmin	Homo sapiens	67-80
2981390-8	1985	Weiss and co-workers demonstrated that phenothiazines and structurally similar drugs are capable of binding to and inhibiting the activity of calmodulin.	Phenothiazines	39-53	calmodulin 1	Homo sapiens	142-152
2986673-13	1985	U.S.A. 78, 6793-6797] that indicated a subclass of calcium-modulated proteins bound phenothiazines in a calcium-dependent manner, demonstrate that the interaction between phenothiazines and calmodulin is more complex than previously assumed, and suggest that extended regions of the calmodulin molecule capable of forming the appropriate conformation are required for specific, high-affinity, calcium-dependent drug binding activity.	Phenothiazines	84-98	calmodulin	Bos taurus	190-200
2986673-13	1985	U.S.A. 78, 6793-6797] that indicated a subclass of calcium-modulated proteins bound phenothiazines in a calcium-dependent manner, demonstrate that the interaction between phenothiazines and calmodulin is more complex than previously assumed, and suggest that extended regions of the calmodulin molecule capable of forming the appropriate conformation are required for specific, high-affinity, calcium-dependent drug binding activity.	Phenothiazines	84-98	calmodulin	Bos taurus	283-293
2986673-13	1985	U.S.A. 78, 6793-6797] that indicated a subclass of calcium-modulated proteins bound phenothiazines in a calcium-dependent manner, demonstrate that the interaction between phenothiazines and calmodulin is more complex than previously assumed, and suggest that extended regions of the calmodulin molecule capable of forming the appropriate conformation are required for specific, high-affinity, calcium-dependent drug binding activity.	Phenothiazines	171-185	calmodulin	Bos taurus	283-293
2995193-1	1985	Phenothiazines and W7, calmodulin antagonists, inhibit the water flow response produced by ADH, exogenous cyclic AMP, phosphodiesterase inhibition and serosal hypertonicity.	Phenothiazines	0-14	calmodulin 1	Homo sapiens	23-33
3995682-0	1985	Inhibition of growth of leukemic cells by inhibitors of calmodulin: phenothiazines and melittin.	Phenothiazines	68-82	calmodulin 1	Homo sapiens	56-66
2995193-4	1985	Phenothiazines inhibited toad bladder calmodulin activation of phosphodiesterase and prevented fluorescent antibody recognition.	Phenothiazines	0-14	calmodulin 1	Homo sapiens	38-48
6090448-6	1984	Antagonists of calcium-binding proteins (i.e. phenothiazines, naphthalene sulfonamides) inhibited the release of O-2 in a fashion compatible with the involvement of calmodulin in these phenomena.	Phenothiazines	46-60	immunoglobulin kappa variable 1D-39	Homo sapiens	113-116
6094787-1	1984	To clarify the role of electrostatic forces in the binding of phenothiazines to calmodulin, the quaternary methiodide salts of several 10-alkylaminophenothiazines were prepared and examined for anticalmodulin activity.	Phenothiazines	62-76	calmodulin 1	Homo sapiens	80-90
6090448-6	1984	Antagonists of calcium-binding proteins (i.e. phenothiazines, naphthalene sulfonamides) inhibited the release of O-2 in a fashion compatible with the involvement of calmodulin in these phenomena.	Phenothiazines	46-60	calmodulin 1	Homo sapiens	165-175
6319437-0	1984	Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides.	Phenothiazines	85-99	alpha-2-macroglobulin	Homo sapiens	8-29
6087356-8	1984	Phenothiazines bind to and inhibit calmodulin, an intracellular calcium-binding protein that regulates several key enzymes, some of which directly affect cytoskeletal elements, although they also may interact nonspecifically with other cellular constituents.	Phenothiazines	0-14	calmodulin 1	Homo sapiens	35-45
16663631-2	1984	This protein is relatively heat stable, binds to hydrophobic gels, and phenothiazines in a calcium-dependent fashion, and binds to antibody to rat testes calmodulin.	Phenothiazines	71-85	calmodulin 1	Rattus norvegicus	154-164
6146320-3	1984	Both serum apo A-I and apo A-II levels were also low (P less than 0.005 and P less than 0.001, respectively) in schizophrenics treated with phenothiazines.	Phenothiazines	140-154	apolipoprotein A1	Homo sapiens	11-31
6323472-11	1984	Thus, calmodulin contains two interaction sites for phenothiazines: one on the NH2-terminal half (fragment 1-77) and one on the COOH-terminal half (fragment 78-148).	Phenothiazines	52-66	calmodulin 1	Homo sapiens	6-16
6234067-3	1984	Phenothiazines bind to calmodulin in a calcium-dependent manner preventing the calmodulin from activating a wide variety of cellular processes.	Phenothiazines	0-14	calmodulin 1	Homo sapiens	23-33
6234067-3	1984	Phenothiazines bind to calmodulin in a calcium-dependent manner preventing the calmodulin from activating a wide variety of cellular processes.	Phenothiazines	0-14	calmodulin 1	Homo sapiens	79-89
6234067-8	1984	These data suggest that phenothiazines stimulate calcium-dependent potassium loss indirectly by a drug-induced blockage of the calmodulin-activated Ca-ATPase.	Phenothiazines	24-38	calmodulin 1	Homo sapiens	127-137
4047382-1	1985	Therapeutic doses of phenothiazines increased serum levels of prolactin, resulting in a number of side effects.	Phenothiazines	21-35	prolactin	Homo sapiens	62-71
6203532-2	1984	Phenothiazines also inhibit the rapid increase in cyclic GMP levels in interferon-treated splenic lymphocytes.	Phenothiazines	0-14	5'-nucleotidase, cytosolic II	Mus musculus	57-60
6319437-0	1984	Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides.	Phenothiazines	85-99	epidermal growth factor	Homo sapiens	34-57
6319437-1	1984	We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.	Phenothiazines	120-134	alpha-2-macroglobulin	Homo sapiens	209-230
6319437-1	1984	We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.	Phenothiazines	120-134	epidermal growth factor	Homo sapiens	236-259
6319437-1	1984	We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.	Phenothiazines	120-134	epidermal growth factor	Homo sapiens	261-264
6188323-7	1982	Phenothiazines and dibenzazepines are chemically related and known to have a high affinity for calmodulin.	Phenothiazines	0-14	calmodulin 1	Homo sapiens	95-105
6664499-10	1983	The phenothiazines, trifluoperazine, fluphenazine and chlorpromazine were found to inhibit the Ca2+-dependent, calmodulin-requiring protein kinase activities of both the chick and rat synaptic membranes.	Phenothiazines	4-18	calmodulin 1	Rattus norvegicus	111-121
6310304-2	1983	It is well known that some of these drugs, including pimozide and the phenothiazines, are inhibitors of calmodulin activity.	Phenothiazines	70-84	calmodulin 1	Rattus norvegicus	104-114
6138140-3	1983	Phenothiazines and other antipsychotic agents, including trifluoperazine, are among the most potent antagonists of calmodulin actions.	Phenothiazines	0-14	calmodulin 1	Homo sapiens	115-125
6176582-4	1982	The rank order of catecholamines, phenothiazines, and related drugs in competing for 3H-agonist binding is indicative of interactions with a D-2 dopamine receptor.	Phenothiazines	34-48	dopamine receptor D2	Bos taurus	141-162
6127080-3	1982	All three phenothiazines effected an increase in the activity of kynurenine hydrolase per unit weight of liver with CPZ showing the highest activation followed by PZ and PMZ.	Phenothiazines	10-24	carboxypeptidase Z	Mus musculus	116-119
6119229-0	1981	Phenothiazines inhibit prolactin secretion in vitro.	Phenothiazines	0-14	prolactin	Homo sapiens	23-32
7202016-0	1982	Interactions between calmodulin and immobilized phenothiazines.	Phenothiazines	48-62	calmodulin 1	Homo sapiens	21-31
7202016-1	1982	The ability of a number of antipsychotic drugs such as phenothiazines to bind to calmodulin with high affinity in a calcium-dependent manner was applied to the study of the nature of their interactions with calmodulin.	Phenothiazines	55-69	calmodulin 1	Homo sapiens	81-91
7202016-1	1982	The ability of a number of antipsychotic drugs such as phenothiazines to bind to calmodulin with high affinity in a calcium-dependent manner was applied to the study of the nature of their interactions with calmodulin.	Phenothiazines	55-69	calmodulin 1	Homo sapiens	207-217
7066322-7	1982	Binding was inhibited by addition of phenothiazines, a group of calmodulin antagonists.	Phenothiazines	37-51	calmodulin 1	Homo sapiens	64-74
6120010-10	1982	Phenothiazines and thioxanthenes antipsychotic agents inhibit calmodulin binding to membranes and calmodulin-dependent activation of adenylate cyclase with a similar order of potency.	Phenothiazines	0-14	calmodulin	Bos taurus	62-72
6120010-10	1982	Phenothiazines and thioxanthenes antipsychotic agents inhibit calmodulin binding to membranes and calmodulin-dependent activation of adenylate cyclase with a similar order of potency.	Phenothiazines	0-14	calmodulin	Bos taurus	98-108
6296889-7	1982	Phenothiazines, such as chlorpromazine inhibit the Ca2+ -pump by antagonizing the increment in activity produced by calmodulin.	Phenothiazines	0-14	calmodulin 1	Homo sapiens	116-126
6787063-2	1981	Our results show that the serum PRL response to metoclopramide is blunted in most patients with phenothiazine-induced hyperprolactinemia, and the serum PRL response to TRH is exaggerated in most patients during and 3 weeks after stopping phenothiazines.	Phenothiazines	238-252	prolactin	Homo sapiens	152-155
6116502-0	1981	Phenothiazines and related compounds disrupt mitochondrial energy production by a calmodulin-independent reaction.	Phenothiazines	0-14	calmodulin 1	Rattus norvegicus	82-92
6116502-1	1981	Phenothiazines and related compounds bind to mitochondrial membranes in approximate proportion to their affinities for calmodulin.	Phenothiazines	0-14	calmodulin 1	Rattus norvegicus	119-129
6263264-2	1980	The ability of a range of phenothiazines to inhibit activation of brain phosphodiesterase by purified calmodulin was studied.	Phenothiazines	26-40	calmodulin 1	Rattus norvegicus	102-112
6163856-9	1981	The results demonstrate that although phenothiazines can act as relatively selective antagonists of calmodulin-induced effects, other effects are possible and cannot be ignored.	Phenothiazines	38-52	calmodulin 1	Homo sapiens	100-110
7008558-4	1981	This reasoning opens the therapeutic door to other calmodulin inhibitors, such as the phenothiazines, which coincidentally, had already been shown to have antisickling properties years ago (59).	Phenothiazines	86-100	calmodulin 1	Homo sapiens	51-61
6272818-4	1981	It was found that phenothiazines at concentrations below 3 mumol/l decisively increase the order parameter of spin label 618, which reports on the interface of the membrane.	Phenothiazines	18-32	spindlin 1	Homo sapiens	110-114
6158670-0	1980	Calmodulin activation of red blood cell (Ca2+ + Mg2+)-ATPase and its antagonism by phenothiazines.	Phenothiazines	83-97	calmodulin 1	Homo sapiens	0-10
9604-8	1976	Basal plasma prolactin values were raised in most patients who were being treated with phenothiazines and were helpful diagnostically in patients with amenorrhoea, galactorrhoea, hypogonadism, cranio-pharyngioma, "non-functioning" pituitary tumours and acromegaly.	Phenothiazines	87-101	prolactin	Homo sapiens	13-22
6112944-2	1980	Certain drugs, such as phenothiazines can antagonize CaM.	Phenothiazines	23-37	calmodulin 1	Homo sapiens	53-56
6112947-1	1980	A number of psychotropic drugs, particularly the phenothiazines and related antipsychotic compounds, inhibit a variety of calmodulin-dependent enzymes.	Phenothiazines	49-63	calmodulin 1	Homo sapiens	122-132
89234-0	1979	[Anti-phenothiazine antibodies and C-reactive protein as possible indicators of developing therapeutic resistance to phenothiazines].	Phenothiazines	117-131	C-reactive protein	Homo sapiens	35-53
648637-0	1978	Effect of phenothiazines on the activity of glycogen phosphorylase b.	Phenothiazines	10-24	glycogen phosphorylase B	Homo sapiens	44-68
895996-3	1977	Some reports have indicated association between breast cancer and prolonged elevated plasma prolactin, such as is seen during treatment with phenothiazines and reserpine.	Phenothiazines	141-155	prolactin	Homo sapiens	92-101
7387339-11	1980	When phenothiazines were added, prolactin increased above drug-free levels.	Phenothiazines	5-19	prolactin	Homo sapiens	32-41
24711-3	1978	The phenothiazines may therefore stimulate melanosome dispersion in the lizard skin by the same mechanism as alpha-MSH; a MSH-mimetic action of phenothiazines may similarly explain their pigmentary action in man.	Phenothiazines	144-158	proopiomelanocortin	Homo sapiens	122-125
24711-4	1978	The pigmentary potency of the phenothiazines corresponded with their therapeutic potency in man; this is in keeping with a neuro-regulatory role for MSH peptides and suggests a possible therapeutic use for them.	Phenothiazines	30-44	proopiomelanocortin	Homo sapiens	149-152
24678-7	1978	The basal concentrations of hPRL were also not different, apart from the findings of elevated hPRL concentrations in three patients previously treated with phenothiazines.	Phenothiazines	156-170	prolactin	Homo sapiens	94-98
13448-6	1976	The mean level of cyclic GMP rose 50 per cent after treatment with phenothiazines (P less than 0.05).	Phenothiazines	67-81	5'-nucleotidase, cytosolic II	Homo sapiens	25-28
13627-5	1976	Still other pharmacological agents such as DMPEA, alpha-methyldopa, reserpine, and certain of the phenothiazines are very effective in causing a stimulation of prolactin secretion.	Phenothiazines	98-112	prolactin	Homo sapiens	160-169
1259521-8	1976	After cessation of phenothiazines, serum prolactin levels rapidly reverted to normal within 48 to 96 hours.	Phenothiazines	19-33	prolactin	Homo sapiens	41-50
1171217-0	1975	Binding study of sulfonylureas and phenothiazines to bovine serum albumin using difference spectrophotometry.	Phenothiazines	35-49	albumin	Homo sapiens	60-73
239662-3	1975	Chlorpromazine and several other phenothiazines have been shown to stimulate prolactin secretion.	Phenothiazines	33-47	prolactin	Homo sapiens	77-86
4152197-0	1974	Blockade of insulin release by certain phenothiazines.	Phenothiazines	39-53	insulin	Homo sapiens	12-19
4675365-0	1972	Binding of phenothiazines to bovine serum albumin and related phenomena.	Phenothiazines	11-25	albumin	Homo sapiens	36-49
4151762-0	1974	The binding behavior of phenothiazines and structurally related compounds to albumin from several species.	Phenothiazines	24-38	albumin	Homo sapiens	77-84
14190467-0	1964	THE PRESERVATION OF BRADYKININ BY PHENOTHIAZINES IN VITRO.	Phenothiazines	34-48	kininogen 1	Homo sapiens	20-30
4560178-0	1972	Prolactin secretion in patients treated with various drugs: phenothiazines, tricyclic antidepressants, reserpine, and methyldopa.	Phenothiazines	60-74	prolactin	Homo sapiens	0-9
4323437-0	1970	Effect of phenothiazines and their sulfoxides on lipoamide dehydrogenase.	Phenothiazines	10-24	dihydrolipoamide dehydrogenase	Homo sapiens	49-72
5003770-0	1971	[Effect of a series of phenothiazines on the NADH cytochrome c-reductase activity of liver microsomes].	Phenothiazines	23-37	cytochrome c, somatic	Homo sapiens	50-62
4988494-0	1970	Effect of phenothiazines on melanoma tyrosinase activity.	Phenothiazines	10-24	tyrosinase	Homo sapiens	37-47
14190467-7	1964	Previous incubation of carboxypeptidase B with phenothiazines and zinc ions greatly reduced the enzymatic inhibition by the phenothiazines, which indicated a possible chelating action by these inhibitors on the metalo-enzyme carboxypeptidase B.	Phenothiazines	47-61	carboxypeptidase B1	Homo sapiens	23-41
14190467-7	1964	Previous incubation of carboxypeptidase B with phenothiazines and zinc ions greatly reduced the enzymatic inhibition by the phenothiazines, which indicated a possible chelating action by these inhibitors on the metalo-enzyme carboxypeptidase B.	Phenothiazines	47-61	carboxypeptidase B1	Homo sapiens	225-243
14190467-7	1964	Previous incubation of carboxypeptidase B with phenothiazines and zinc ions greatly reduced the enzymatic inhibition by the phenothiazines, which indicated a possible chelating action by these inhibitors on the metalo-enzyme carboxypeptidase B.	Phenothiazines	124-138	carboxypeptidase B1	Homo sapiens	23-41
14190467-7	1964	Previous incubation of carboxypeptidase B with phenothiazines and zinc ions greatly reduced the enzymatic inhibition by the phenothiazines, which indicated a possible chelating action by these inhibitors on the metalo-enzyme carboxypeptidase B.	Phenothiazines	124-138	carboxypeptidase B1	Homo sapiens	225-243
31813721-1	2020	A new phenothiazine derivative as lysosome-targeted fluorescent probe with a large blue-shift (128 nm) for ClO- detection in a fine ratiometric manner has been designed and synthesized.	Phenothiazines	6-19	neuronal PAS domain protein 4 like	Danio rerio	107-110
32829256-2	2020	In this study we predict, using molecular docking, the binding affinity of 15 phenothiazines (antihistaminic and antipsychotic drugs) when interacting with the main protease (Mpro) of SARS-CoV-2.	Phenothiazines	78-92	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	175-179
32309275-0	2020	Competition Between Phenothiazines and BH3 Peptide for the Binding Site of the Antiapoptotic BCL-2 Protein.	Phenothiazines	20-34	BCL2 apoptosis regulator	Homo sapiens	93-98
31945636-0	2020	Co-effects of the electron transfer and intersystem crossing on the photophysics of a phenothiazine based Hg2+ sensor.	Phenothiazines	86-99	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	106-109
13927590-0	1962	[Changes in activity of pancreatic lipase under the influence of phenothiazines].	Phenothiazines	65-79	pancreatic lipase	Homo sapiens	24-41
32526553-3	2020	Phenothiazines (PTZs) represent one of the most known class of NDH-2 inhibitors, but their use as anti-TB drugs is currently limited by the wide range of potentially serious off-target effects.	Phenothiazines	0-14	DExH-box helicase 9	Homo sapiens	63-68
32526553-3	2020	Phenothiazines (PTZs) represent one of the most known class of NDH-2 inhibitors, but their use as anti-TB drugs is currently limited by the wide range of potentially serious off-target effects.	Phenothiazines	16-20	DExH-box helicase 9	Homo sapiens	63-68
31847503-0	2019	Reduced Apoptotic Injury by Phenothiazine in Ischemic Stroke through the NOX-Akt/PKC Pathway.	Phenothiazines	28-41	AKT serine/threonine kinase 1	Rattus norvegicus	77-80
31738060-2	2020	Four novel TADF emitters using 9,9-dimethylacridine, phenoxazine, phenothiazine, and bis(di-p-tolylamino)carbazole as the donor group were designed and synthesized using IMAC as the acceptor.	Phenothiazines	66-79	C-C motif chemokine ligand 26	Homo sapiens	170-174
31880924-0	2020	Unprecedented Properties of Phenothiazines Unraveled by a NDH-2 Bioelectrochemical Assay Platform.	Phenothiazines	28-42	DExH-box helicase 9	Homo sapiens	58-63
31880924-6	2020	Furthermore, when phenothiazines, one of the most commonly identified NDH-2 inhibitors, were tested, they did not inhibit membrane-bound NDH-2.	Phenothiazines	18-32	DExH-box helicase 9	Homo sapiens	70-75
30382490-0	2019	Effects of Phenothiazines on Aldehyde Oxidase Activity Towards Aldehydes and N-Heterocycles: an In Vitro and In Silico Study.	Phenothiazines	11-25	acyl-CoA oxidase 1	Rattus norvegicus	29-45
31843022-3	2019	This study assessed if methylene blue (MB), a phenothiazine that inhibits caspases, alters Caspase-6-induced neurodegeneration and cognitive impairment in mice.	Phenothiazines	46-59	caspase 6	Homo sapiens	74-82
31576837-0	2019	Butterfly architecture of NIR Aza-BODIPY small molecules decorated with phenothiazine or phenoxazine.	Phenothiazines	72-85	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	26-29
31576837-2	2019	The molecular engineering of newly synthesized NIR absorbing Aza-Bodipy dyes consists of covalently linked phenothiazine (AZA-PTZ-BOD) and phenoxazine (AZA-POZ-BOD) moieties as terminal groups and Aza-Bodipy as a central core moiety.	Phenothiazines	107-120	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	47-50
30382490-6	2019	RESULTS: All phenothiazines could inhibit AOX activity measured either by phenanthridine or benzaldehyde with almost no effect on XO activity.	Phenothiazines	13-27	acyl-CoA oxidase 1	Rattus norvegicus	42-45
30659501-0	2019	Correction to: Effects of Phenothiazines on Aldehyde Oxidase Activity Towards Aldehydes and N-Heterocycles: an In Vitro and In Silico Study.	Phenothiazines	26-40	aldehyde oxidase 1	Homo sapiens	44-60
31007848-4	2019	To this end, we queried the Connectivity Map with an AXL gene signature which revealed a class of dopamine receptors antagonists named phenothiazines (Thioridazine, Fluphenazine and Trifluoperazine) typically used as anti-psychotics.	Phenothiazines	135-149	AXL receptor tyrosine kinase	Homo sapiens	53-56
30813251-0	2019	The Combined Use of Phenothiazines and Statins Strongly Affects Doxorubicin-Resistance, Apoptosis, and Cox-2 Activity in Colon Cancer Cells.	Phenothiazines	20-34	ATP binding cassette subfamily B member 1	Homo sapiens	64-86
30813251-0	2019	The Combined Use of Phenothiazines and Statins Strongly Affects Doxorubicin-Resistance, Apoptosis, and Cox-2 Activity in Colon Cancer Cells.	Phenothiazines	20-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-108
28785051-0	2017	Phenothiazines Enhance Mild Hypothermia-induced Neuroprotection via PI3K/Akt Regulation in Experimental Stroke.	Phenothiazines	0-14	AKT serine/threonine kinase 1	Rattus norvegicus	73-76
28809437-1	2017	OBJECTIVES: To study the functional consequences of the human and rat forms of OCT2 in the presence of phenothiazines.	Phenothiazines	103-117	solute carrier family 22 member 2	Rattus norvegicus	79-83
28885854-3	2017	Both H-atom transfer and one-electron oxidation are enhanced by substitution with electron-donating substituents, such as the S-atom in phenothiazines, another important class of RTA.	Phenothiazines	136-150	MAS related GPR family member F	Homo sapiens	179-182
28377303-8	2017	Benzophenoxazines such as cresyl violet and Nile blue are, similar to phenothiazines (e.g. MB), representative of high potency MAO-A inhibitors with a potential risk of ST.	Phenothiazines	70-84	monoamine oxidase A	Homo sapiens	127-132
28472892-11	2017	Phenothiazines are potent inhibitor of NDH-2 and are effective against both drug-susceptible and drug-resistant Mtb.	Phenothiazines	0-14	DExH-box helicase 9	Homo sapiens	39-44
28366621-4	2017	Using a phenotypic screening strategy, we identified a series of piperazine phenothiazines, including trifluoperazine, which rescued Pink1 deficiency by activating autophagy selectively in stressed zebrafish and human cells.	Phenothiazines	76-90	PTEN induced kinase 1	Danio rerio	133-138
26820562-0	2016	Binding of phenothiazines into allosteric hydrophobic pocket of human thioredoxin 1.	Phenothiazines	11-25	thioredoxin	Homo sapiens	70-81
28119500-0	2017	Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.	Phenothiazines	57-71	ric8a	Drosophila melanogaster	46-51
27296777-1	2016	In this study, the inhibitory effects of three phenothiazines [toluidine blue O (TBO), thionine (TH) and methylene violet (MV)] were tested on human plasma butyrylcholinesterase (BChE) and their inhibitory mechanisms were studied in detail.	Phenothiazines	47-61	butyrylcholinesterase	Homo sapiens	156-177
27296777-1	2016	In this study, the inhibitory effects of three phenothiazines [toluidine blue O (TBO), thionine (TH) and methylene violet (MV)] were tested on human plasma butyrylcholinesterase (BChE) and their inhibitory mechanisms were studied in detail.	Phenothiazines	47-61	butyrylcholinesterase	Homo sapiens	179-183
26026084-0	2015	Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells by Phenothiazines.	Phenothiazines	82-96	ATP binding cassette subfamily B member 1	Homo sapiens	12-17
25763457-4	2015	Even the phenothiazines are very weak inhibitors of S100A4 action.	Phenothiazines	9-23	S100 calcium binding protein A4	Homo sapiens	52-58
25863440-12	2015	Computer-aided molecular docking was consistent, indicating that both phenothiazines are situated within the pocket composed of alpha1 and beta2 subunits.	Phenothiazines	70-84	adrenoceptor alpha 1D	Homo sapiens	128-134
25863440-12	2015	Computer-aided molecular docking was consistent, indicating that both phenothiazines are situated within the pocket composed of alpha1 and beta2 subunits.	Phenothiazines	70-84	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	139-144
26757771-6	2016	Additional glucose alleviated sensitivity to local anesthetics and phenothiazines in the HXT1m strain but not the HXT1s strain; thus, the glucose-induced effects required a certain amount of Hxt1.	Phenothiazines	67-81	hexose transporter HXT1	Saccharomyces cerevisiae S288C	89-93
25119673-9	2015	Because other local anesthetics and phenothiazines induced Pat1-dependent P-body formation, the mechanisms involved in translational inhibition by these cationic amphiphiles are similar.	Phenothiazines	36-50	Pat1p	Saccharomyces cerevisiae S288C	59-63
24692704-0	2014	Multidrug resistance reversing activity of newly developed phenothiazines on P-glycoprotein (ABCB1)-related resistance of mouse T-lymphoma cells.	Phenothiazines	59-73	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	93-98
25350551-1	2014	Photoactive supramolecules composed of two entities of carbamoyl phenothiazines (PTZ) positioned at different locations of the BF2-chelated azadipyrromethene (azaBODIPY) periphery and fulleropyrrolidine (C60) have been newly designed and synthesized to probe excited state events.	Phenothiazines	81-84	forkhead box G1	Homo sapiens	127-130
24692704-1	2014	BACKGROUND: Phenothiazines have anticancer properties and are able to reverse the multidrug resistance of neoplastic cells by inhibiting the ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein (ABCB1 or P-glycoprotein) activity.	Phenothiazines	12-26	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	141-195
24692704-1	2014	BACKGROUND: Phenothiazines have anticancer properties and are able to reverse the multidrug resistance of neoplastic cells by inhibiting the ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein (ABCB1 or P-glycoprotein) activity.	Phenothiazines	12-26	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	205-210
24692704-4	2014	The inhibition of the ABCB1 transporter in the presence of the newly-developed phenothiazines was greater than that for the known ABCB1 inhibitors thioridazine and verapamil.	Phenothiazines	79-93	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	22-27
24692704-4	2014	The inhibition of the ABCB1 transporter in the presence of the newly-developed phenothiazines was greater than that for the known ABCB1 inhibitors thioridazine and verapamil.	Phenothiazines	79-93	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	130-135
23406770-6	2012	CONCLUSION: The obtained results suggest that the tested phenothiazines may stimulate their own metabolism by inducing CYP1A2, CYP3A4 and CYP2C19 isoforms.	Phenothiazines	57-71	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	119-125
24401270-0	2014	Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.	Phenothiazines	0-14	protein phosphatase 2 phosphatase activator	Homo sapiens	22-26
25794302-0	2014	Pharmacophore based 3DQSAR of phenothiazines as specific human butyrylcholinesterase inhibitors for treatment of Alzheimer"s disease.	Phenothiazines	30-44	butyrylcholinesterase	Homo sapiens	63-84
25546944-1	2014	Our previous studies demonstrated that among phenothiazines several derivatives could be found showing strong antiproliferative actions and the property of inhibiting inducible tumor necrosis factor alpha (TNF a) production in human blood cultures.	Phenothiazines	45-59	tumor necrosis factor	Homo sapiens	177-204
25546944-1	2014	Our previous studies demonstrated that among phenothiazines several derivatives could be found showing strong antiproliferative actions and the property of inhibiting inducible tumor necrosis factor alpha (TNF a) production in human blood cultures.	Phenothiazines	45-59	tumor necrosis factor	Homo sapiens	206-211
23707254-7	2013	We demonstrate that phenothiazines can be prepared without significant neurotransmitter receptor interactions while retaining high potency as cholinesterase ligands for treatment of Alzheimer"s disease.	Phenothiazines	20-34	butyrylcholinesterase	Homo sapiens	142-156
23238017-0	2012	Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.	Phenothiazines	46-60	MALT1 paracaspase	Homo sapiens	28-33
23238017-2	2012	We have identified distinct derivatives of medicinal active phenothiazines, namely mepazine, thioridazine, and promazine, as small molecule inhibitors of the MALT1 protease.	Phenothiazines	60-74	MALT1 paracaspase	Homo sapiens	158-172
23238017-3	2012	These phenothiazines selectively inhibit cleavage activity of recombinant and cellular MALT1 by a noncompetitive mechanism.	Phenothiazines	6-20	MALT1 paracaspase	Homo sapiens	87-92
22683890-3	2012	Thienothiazines are compounds sharing some structural features with phenothiazines, which are known to be potent BChE inhibitors.	Phenothiazines	68-82	butyrylcholinesterase	Homo sapiens	113-117
25387336-1	2014	Since the discovery of phenothiazines as tau protein aggregation inhibitors, many additional small molecule inhibitors of diverse chemotype have been discovered and characterized in biological model systems.	Phenothiazines	23-37	microtubule associated protein tau	Homo sapiens	41-44
24275522-16	2014	For example, there is evidence that an old class of drugs, the phenothiazines, is antiproliferative in cancer cell lines via inhibition of calmodulin and/or histaminic pathways.	Phenothiazines	63-77	calmodulin 1	Homo sapiens	139-149
24130798-0	2013	UV-light effects on cytochrome c modulated by the aggregation state of phenothiazines.	Phenothiazines	71-85	cytochrome c, somatic	Homo sapiens	20-32
24130798-4	2013	The presence of phenothiazines at the concentration range 10-25 micromol/L amplified and accelerated a cytochrome c blue shift (409 to 405 nm, at a rate = 0.041 nm/min).	Phenothiazines	16-30	cytochrome c, somatic	Homo sapiens	103-115
24130798-5	2013	Above 25 micromol/L, crescent concentrations of phenothiazines contributed to cytochrome c protection with (maximal at 2500 micromol/L).	Phenothiazines	48-62	cytochrome c, somatic	Homo sapiens	78-90
23406770-6	2012	CONCLUSION: The obtained results suggest that the tested phenothiazines may stimulate their own metabolism by inducing CYP1A2, CYP3A4 and CYP2C19 isoforms.	Phenothiazines	57-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	127-133
23406770-6	2012	CONCLUSION: The obtained results suggest that the tested phenothiazines may stimulate their own metabolism by inducing CYP1A2, CYP3A4 and CYP2C19 isoforms.	Phenothiazines	57-71	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	138-145
21789246-8	2011	A number of small molecules, including phenothiazines, were found that induced a gene signature in breast cancer cell lines opposite to that found in tamoxifen resistant vs. sensitive tumors and the ability of phenothiazines to down-regulate cyclin E2 and inhibit proliferation of tamoxifen resistant breast cancer cells was validated.	Phenothiazines	39-53	cyclin E2	Homo sapiens	242-251
22187677-0	2011	Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1.	Phenothiazines	15-29	ATP binding cassette subfamily B member 1	Homo sapiens	107-121
22187677-0	2011	Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1.	Phenothiazines	15-29	ATP binding cassette subfamily C member 1	Homo sapiens	126-130
22187677-5	2011	In the present review, interactions of three groups of modulators: phenothiazines, flavonoids and stilbenes with both P-glycoprotein and MRP1 are discussed.	Phenothiazines	67-81	ATP binding cassette subfamily B member 1	Homo sapiens	118-132
22187677-5	2011	In the present review, interactions of three groups of modulators: phenothiazines, flavonoids and stilbenes with both P-glycoprotein and MRP1 are discussed.	Phenothiazines	67-81	ATP binding cassette subfamily C member 1	Homo sapiens	137-141
21869564-5	2011	Phenothiazines such as CPZ, trifluoperazine (TFPZ), and promethazine (PMZ) inhibited s-RANKL-induced osteoclast-like cell formation in mouse BMCs.	Phenothiazines	0-14	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	87-92
22358097-7	2011	The in vivo inhibition of CYP2C11 by chronic treatment with the three phenothiazines suggests their influence on the enzyme regulation.	Phenothiazines	70-84	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	26-33
21789246-8	2011	A number of small molecules, including phenothiazines, were found that induced a gene signature in breast cancer cell lines opposite to that found in tamoxifen resistant vs. sensitive tumors and the ability of phenothiazines to down-regulate cyclin E2 and inhibit proliferation of tamoxifen resistant breast cancer cells was validated.	Phenothiazines	210-224	cyclin E2	Homo sapiens	242-251
20619250-11	2010	Since PTZ give rise to cation radicals chemically by the action of peroxidases and cyanide inhibited the PTZ-induced swelling, we propose that PTZ bury in the inner mitochondrial membrane and the chemically generated PTZ cation radicals modify specific thiol groups that in the presence of Ca(2+) result in MPT associated to cytochrome c release.	Phenothiazines	6-9	cytochrome c, somatic	Homo sapiens	325-337
20615392-0	2010	Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver--A comparison with other phenothiazines.	Phenothiazines	191-205	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	56-62
20619250-11	2010	Since PTZ give rise to cation radicals chemically by the action of peroxidases and cyanide inhibited the PTZ-induced swelling, we propose that PTZ bury in the inner mitochondrial membrane and the chemically generated PTZ cation radicals modify specific thiol groups that in the presence of Ca(2+) result in MPT associated to cytochrome c release.	Phenothiazines	105-108	cytochrome c, somatic	Homo sapiens	325-337
20619250-11	2010	Since PTZ give rise to cation radicals chemically by the action of peroxidases and cyanide inhibited the PTZ-induced swelling, we propose that PTZ bury in the inner mitochondrial membrane and the chemically generated PTZ cation radicals modify specific thiol groups that in the presence of Ca(2+) result in MPT associated to cytochrome c release.	Phenothiazines	105-108	cytochrome c, somatic	Homo sapiens	325-337
17606915-9	2007	Further computational optimization of phenothiazines, combined with in vitro screening, led to the identification of a nonsteroidal antiandrogen with improved AR antagonism and marked reduction in affinity for dopaminergic and serotonergic receptors that are the primary target of phenothiazine antipsychotics.	Phenothiazines	38-52	androgen receptor	Homo sapiens	159-161
20421509-0	2010	Phenothiazines inhibit S100A4 function by inducing protein oligomerization.	Phenothiazines	0-14	S100 calcium binding protein A4	Homo sapiens	23-29
20421509-13	2010	Together these studies support a unique mode of inhibition in which phenothiazines disrupt the S100A4/myosin-IIA interaction by sequestering S100A4 via small molecule-induced oligomerization.	Phenothiazines	68-82	S100 calcium binding protein A4	Homo sapiens	95-101
20421509-13	2010	Together these studies support a unique mode of inhibition in which phenothiazines disrupt the S100A4/myosin-IIA interaction by sequestering S100A4 via small molecule-induced oligomerization.	Phenothiazines	68-82	S100 calcium binding protein A4	Homo sapiens	141-147
18837915-0	2008	Potential inhibition of PDK1/Akt signaling by phenothiazines suppresses cancer cell proliferation and survival.	Phenothiazines	46-60	pyruvate dehydrogenase kinase 1	Homo sapiens	24-28
18837915-0	2008	Potential inhibition of PDK1/Akt signaling by phenothiazines suppresses cancer cell proliferation and survival.	Phenothiazines	46-60	AKT serine/threonine kinase 1	Homo sapiens	29-32
18837915-4	2008	In this paper, we report the discovery of a new function of phenothiazines, widely known as antipsychotics, inhibiting PDK1/Akt pathway.	Phenothiazines	60-74	pyruvate dehydrogenase kinase 1	Homo sapiens	119-123
18837915-4	2008	In this paper, we report the discovery of a new function of phenothiazines, widely known as antipsychotics, inhibiting PDK1/Akt pathway.	Phenothiazines	60-74	AKT serine/threonine kinase 1	Homo sapiens	124-127
18837915-5	2008	Upon epidermal growth factor (EGF) stimulation, phenothiazines specifically suppressed the kinase activity of PDK1 and the phosphorylation level of Akt.	Phenothiazines	48-62	epidermal growth factor	Homo sapiens	5-28
18837915-5	2008	Upon epidermal growth factor (EGF) stimulation, phenothiazines specifically suppressed the kinase activity of PDK1 and the phosphorylation level of Akt.	Phenothiazines	48-62	epidermal growth factor	Homo sapiens	30-33
18837915-5	2008	Upon epidermal growth factor (EGF) stimulation, phenothiazines specifically suppressed the kinase activity of PDK1 and the phosphorylation level of Akt.	Phenothiazines	48-62	pyruvate dehydrogenase kinase 1	Homo sapiens	110-114
18837915-5	2008	Upon epidermal growth factor (EGF) stimulation, phenothiazines specifically suppressed the kinase activity of PDK1 and the phosphorylation level of Akt.	Phenothiazines	48-62	AKT serine/threonine kinase 1	Homo sapiens	148-151
18837915-7	2008	In particular, phenothiazines were highly selective for downstream targets of PDK1/Akt and did not inhibit the activation of phosphatidylinositol 3-kinase (PI3K), EGFR, or extracellular signal-regulated kinase 1/2 (ERK1/2).	Phenothiazines	15-29	pyruvate dehydrogenase kinase 1	Homo sapiens	78-82
18837915-7	2008	In particular, phenothiazines were highly selective for downstream targets of PDK1/Akt and did not inhibit the activation of phosphatidylinositol 3-kinase (PI3K), EGFR, or extracellular signal-regulated kinase 1/2 (ERK1/2).	Phenothiazines	15-29	AKT serine/threonine kinase 1	Homo sapiens	83-86
18524847-0	2008	In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation.	Phenothiazines	50-64	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	103-107
18524847-9	2008	The studies provide evidence that BRAF mutation (codon 600) in melanoma as opposed to RAS mutation is predictive of an increase in sensitivity to phenothiazines as determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt assay (Wilcoxon P = 0.007).	Phenothiazines	146-160	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	34-38
18524847-10	2008	That pattern of increased sensitivity to phenothiazines based on the presence of codon 600 BRAF mutation may be unique to melanomas, as we do not observe it in a panel of colorectal cancers.	Phenothiazines	41-55	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	91-95
18524847-11	2008	The findings reported here have potential implications for the use of phenothiazines in the treatment of V600E BRAF mutant melanoma.	Phenothiazines	70-84	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	111-115
18154362-6	2008	Additionally, a screen against a library of FDA-approved drugs with the biosensor identified an array of phenothiazines as inhibitors of myosin-II associated S100A4 function.	Phenothiazines	105-119	S100 calcium binding protein A4	Homo sapiens	158-164
20715845-5	2010	Here, by high-throughput screening, we identify a subset of phenothiazines, 2-acetylphenothiazine (here referred to as ML171) (and its related 2-(trifluoromethyl)-phenothiazine) as nanomolar, cell-active, and specific Nox1 inhibitors that potently block Nox1-dependent ROS generation, with only marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms.	Phenothiazines	60-74	NADPH oxidase 1	Homo sapiens	218-222
20715845-5	2010	Here, by high-throughput screening, we identify a subset of phenothiazines, 2-acetylphenothiazine (here referred to as ML171) (and its related 2-(trifluoromethyl)-phenothiazine) as nanomolar, cell-active, and specific Nox1 inhibitors that potently block Nox1-dependent ROS generation, with only marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms.	Phenothiazines	60-74	NADPH oxidase 1	Homo sapiens	254-258
20023237-0	2009	Differential effect of phenothiazines on MRP1 and P-glycoprotein activity.	Phenothiazines	23-37	ATP binding cassette subfamily C member 1	Homo sapiens	41-45
20023237-0	2009	Differential effect of phenothiazines on MRP1 and P-glycoprotein activity.	Phenothiazines	23-37	ATP binding cassette subfamily B member 1	Homo sapiens	50-64
18946562-7	2008	Since phenothiazines are calmodulin antagonists, this property of the drugs was tested as reduction of thrombin-induced phosphorylation of MLC in [32P] Pi-labelled platelets.	Phenothiazines	6-20	coagulation factor II, thrombin	Homo sapiens	103-111
18946562-7	2008	Since phenothiazines are calmodulin antagonists, this property of the drugs was tested as reduction of thrombin-induced phosphorylation of MLC in [32P] Pi-labelled platelets.	Phenothiazines	6-20	modulator of VRAC current 1	Homo sapiens	139-142
18837915-9	2008	Taken together, these findings provide strong evidence for novel function of phenothiazines, pharmacologically targeting PDK1/Akt for anticancer drug discovery.	Phenothiazines	77-91	pyruvate dehydrogenase kinase 1	Homo sapiens	121-125
18837915-9	2008	Taken together, these findings provide strong evidence for novel function of phenothiazines, pharmacologically targeting PDK1/Akt for anticancer drug discovery.	Phenothiazines	77-91	AKT serine/threonine kinase 1	Homo sapiens	126-129
16681381-3	2006	Several polyphenols, phenothiazines, porphyrins, polyene macrolides, and Congo red and its derivatives, BSB and FSB, inhibited alpha-synuclein filament assembly with IC(50) values in the low micromolar range.	Phenothiazines	21-35	synuclein alpha	Homo sapiens	127-142
17448610-0	2007	Consideration of use of phenothiazines in particular trifluorperazine for epidermal growth factor receptor associated cancers.	Phenothiazines	24-38	epidermal growth factor receptor	Homo sapiens	74-106
17448610-1	2007	Papers from a generation ago suggested that phenothiazines--in particular trifluorperazine (Stelazine) a medicinal approved by the FDA and still commonly used for schizophrenia--downregulate the epidermal growth factor receptor.	Phenothiazines	44-58	epidermal growth factor receptor	Homo sapiens	195-227
17448610-2	2007	As numerous cancers--e.g., colon cancer, breast cancer, pancreatic cancer and glioblastoma--are dependent on signaling via this receptor, we here suggest that phenothiazines such as trifluorperazine be considered for use in epidermal growth factor receptor associated cancers.	Phenothiazines	159-173	epidermal growth factor receptor	Homo sapiens	224-256
17168814-6	2006	Calmodulin mediated processes can be effectively inhibited by a variety of pharmacological agents of different chemical structures, eg:The calcium channel blocker verapamil and antipsychotic drugs like the Phenothiazines.	Phenothiazines	206-220	calmodulin 1	Homo sapiens	0-10
17168814-7	2006	Many bioisosteres of phenothiazines like phenoxazines and acridones have been prepared and these have also shown very good calmodulin antagonism.	Phenothiazines	21-35	calmodulin 1	Homo sapiens	123-133
15582466-4	2005	To explore features of phenothiazines that affect the selectivity and potency of BuChE inhibition, a series of N-carbonyl derivatives (5-25) was synthesized and examined for the ability to inhibit cholinesterases.	Phenothiazines	23-37	butyrylcholinesterase	Homo sapiens	81-86
16277027-7	2005	Moreover, compounds BD-3, A-9 and 5-(2-thienylcarboxyamido)-2-phenylbenzoxazole (D-24) also amplified the apoptosis effect of 12H-benzo(a)phenothiazines (M-627).	Phenothiazines	138-152	UDP glucuronosyltransferase 1 family, polypeptide A6B	Mus musculus	26-29
15572279-5	2005	Thioridazine (Ki=15 microM) was the most potent inhibitor of the rat CYP2D among the drugs studied, whose effect was more pronounced than that of the other neuroleptics tested: phenothiazines (Ki=18-23 microM), haloperidol (Ki=32 microM), sertindole (Ki=51 microM) or risperidone (Ki=165 microM).	Phenothiazines	177-191	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	69-74
15572279-8	2005	After chronic treatment with the investigated neuroleptics, the decreased CYP2D activity produced by the phenothiazines was still maintained, while that caused by haloperidol diminished.	Phenothiazines	105-119	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	74-79
15595868-8	2004	Calmodulin undergoes a conformational change upon binding to phenothiazines that alters the fluorescence properties of the attached fluorescent protein, which can be correlated to the concentration of the drug present.	Phenothiazines	61-75	calmodulin 1	Homo sapiens	0-10
14758987-0	2003	QSAR studies on P-glycoprotein-regulated multidrug resistance and on its reversal by phenothiazines.	Phenothiazines	85-99	ATP binding cassette subfamily B member 1	Homo sapiens	16-30
14681337-6	2004	Other classes of drugs that demonstrated inhibition of aldehyde oxidase included phenothiazines, tricyclic antidepressants, tricyclic atypical antipsychotic agents, and dihydropyridine calcium channel blockers, along with some other drugs, including loratadine, cyclobenzaprine, amodiaquine, maprotiline, ondansetron, propafenone, domperidone, quinacrine, ketoconazole, verapamil, tacrine, and salmeterol.	Phenothiazines	81-95	aldehyde oxidase 1	Homo sapiens	55-71
12792975-2	2003	Phenothiazines containing aromatic moieties were bound through stacking interaction involving the polarization of the aromatic aminoacid substituents at the target site of p-glycoprotein (Pgp) 170, as a consequence of their large dipoles (as in the binding of phenothiazine to calmodulin-like structures).	Phenothiazines	0-14	phosphoglycolate phosphatase	Mus musculus	172-186
13678835-2	2003	We evaluated the growth inhibitory and MDR modulatory effect of a series of 36 phenothiazines and related compounds, against Saccharomyces cerevisiae strains exhibiting different levels of expression of MDR transporters Pdr5p, Snq2p and Yor1p.	Phenothiazines	79-93	ATP-binding cassette transporter YOR1	Saccharomyces cerevisiae S288C	237-242
12755594-7	2003	Primer extension analysis of plasmid DNA irradiated in the presence of phenothiazines indicates that photocleavage of DNA occurs predominantly at Gua and Cyt residues.	Phenothiazines	71-85	DExD-box helicase 21	Homo sapiens	146-149
12792975-2	2003	Phenothiazines containing aromatic moieties were bound through stacking interaction involving the polarization of the aromatic aminoacid substituents at the target site of p-glycoprotein (Pgp) 170, as a consequence of their large dipoles (as in the binding of phenothiazine to calmodulin-like structures).	Phenothiazines	0-14	phosphoglycolate phosphatase	Mus musculus	188-191
12792975-4	2003	Most probably the tyrosine moieties of Pgp are involved in the action of verapamil and phenothiazines.	Phenothiazines	87-101	phosphoglycolate phosphatase	Mus musculus	39-42
12208554-10	2002	The results obtained point to the drug structure and species differences in the contribution of cytochrome P-450 isoenzymes to the metabolism of phenothiazines.	Phenothiazines	145-159	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	96-112
11322935-11	2001	In conclusion, invasion of T-cells across cellular monolayers is inhibited both by PIM and by phenothiazines like TFP and CP, but via distinct mechanisms: TFP and CP inhibit lymphocyte motility via a calmodulin independent pathway, whereas PIM impairs the monolayer"s tolerance for invasion, most likely via a calmodulin and CamKII dependent pathway.	Phenothiazines	94-108	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	114-117
12387684-4	2002	Short-term acute studies done after single parenteral or oral doses of phenothiazines found rapid two- to tenfold increases in hPrl.	Phenothiazines	71-85	prolactin	Homo sapiens	127-131
11839208-8	2002	Both phenothiazines on filter paper discs bound [3H] pBR 322 DNA to a far greater extent than chloroquine.	Phenothiazines	5-19	translocator protein	Homo sapiens	53-56
11350043-4	2001	We tested a panel of phenothiazines and one thioxanthen for any influence upon the activity and expression of DNA-PK in a nonsmall cell lung cancer cell line, U-1810.	Phenothiazines	21-35	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	110-116
11350043-7	2001	Our study suggests that phenothiazines and thioxanthens, acting through DNA-PK, have the potential to enhance the effects of DNA damaging agents.	Phenothiazines	24-38	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	72-78
11369031-0	2001	Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines.	Phenothiazines	172-186	potassium calcium-activated channel subfamily N member 3	Homo sapiens	100-104
11369031-6	2001	Tricyclic antidepressants such as desipramine, imipramine and nortriptyline as well as phenothiazines such as fluphenazine, promethazine, chlorpromazine and trifluoperazine blocked the hSK3 channel with micromolar potencies.	Phenothiazines	87-101	potassium calcium-activated channel subfamily N member 3	Homo sapiens	185-189
10955855-6	2000	Antiemetic drugs such as metoclopramide and phenothiazines, known to enhance pituitary prolactin secretion, further elevated prolactin plasma levels (p &lt; 0.00001).	Phenothiazines	44-58	prolactin	Homo sapiens	87-96
10955855-6	2000	Antiemetic drugs such as metoclopramide and phenothiazines, known to enhance pituitary prolactin secretion, further elevated prolactin plasma levels (p &lt; 0.00001).	Phenothiazines	44-58	prolactin	Homo sapiens	125-134
9713505-4	1998	Some selected antitumor phenothiazines and benzo[a]phenothiazines, including trifluoperazine inhibit the P-glycoprotein (pgp) function.	Phenothiazines	24-38	phosphoglycolate phosphatase	Mus musculus	105-119
10910470-2	2000	"Shuttle Oxidant" effect of lipoxygenase-generated radical of chlorpromazine and related phenothiazines on the oxidation of benzidine and other xenobiotics.	Phenothiazines	89-103	linoleate 9S-lipoxygenase-4	Glycine max	28-40
10608490-0	1999	A comparison of the effect of five phenothiazines on hepatic CYP isoenzymes in rats.	Phenothiazines	35-49	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	61-64
10379845-0	1999	N-demethylation of phenothiazines by lipoxygenase from soybean and human term placenta in the presence of hydrogen peroxide.	Phenothiazines	19-33	linoleate 9S-lipoxygenase-4	Glycine max	37-49
10379845-3	1999	In this study, we investigated hydrogen peroxide-dependent oxidation of six phenothiazines by purified lipoxygenase from soybean (SLO) and human term placenta (HTPLO).	Phenothiazines	76-90	linoleate 9S-lipoxygenase-4	Glycine max	103-115
10379845-15	1999	The evidence gathered in this in vitro study suggests that phenothiazines can undergo peroxidative N-demethylation via lipoxygenase pathway.	Phenothiazines	59-73	linoleate 9S-lipoxygenase-4	Glycine max	119-131
9713505-4	1998	Some selected antitumor phenothiazines and benzo[a]phenothiazines, including trifluoperazine inhibit the P-glycoprotein (pgp) function.	Phenothiazines	24-38	phosphoglycolate phosphatase	Mus musculus	121-124
9713505-7	1998	The efflux pump activity of the pgp in brain capillary endothel which is responsible for blood brain barrier (BBB) was also inhibited by some phenothiazines.	Phenothiazines	142-156	phosphoglycolate phosphatase	Mus musculus	32-35
9713505-9	1998	The mdr-gene expression of the mouse lymphoma cells (which were transfected with the human mdr-1 gene) could be reduced by phenothiazines such as promethazine and trifluoperazine, when the cells were cultured in the presence of 0.5 microgram/mL phenothiazines.	Phenothiazines	123-137	ATP binding cassette subfamily B member 1	Homo sapiens	91-96
9713505-9	1998	The mdr-gene expression of the mouse lymphoma cells (which were transfected with the human mdr-1 gene) could be reduced by phenothiazines such as promethazine and trifluoperazine, when the cells were cultured in the presence of 0.5 microgram/mL phenothiazines.	Phenothiazines	245-259	ATP binding cassette subfamily B member 1	Homo sapiens	91-96
9871539-1	1998	A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified.	Phenothiazines	12-26	C-C motif chemokine ligand 5	Homo sapiens	55-61
9673343-3	1998	We have investigated the influence of trifluoperazine (TFP--a species of phenothiazines) and its newly prepared TFP-metal complexes (TFP-VO(IV), TFP-Cu(II), TFP-Ni(II), TFP-Pd(II), TFP-Sn(IV)).	Phenothiazines	73-87	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	55-58
9568379-8	1998	Ephedrine, propranolol and phenothiazines including trifluoparazine (TPZ) caused non-competitive inhibition, while hexamethonium caused an uncompetitive inhibition of AChE activity.	Phenothiazines	27-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-171
8855335-0	1996	Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.	Phenothiazines	66-80	microtubule associated protein tau	Homo sapiens	47-50
9568379-0	1998	Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase.	Phenothiazines	26-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-91
9067460-3	1997	Here we report protective effects of phenothiazines, a class of neuroleptic agent, against A beta toxicity in primary cultures of rat cortical neurons and PC12 cells.	Phenothiazines	37-51	amyloid beta precursor protein	Rattus norvegicus	91-97
8843336-5	1996	The results of this study show that chlorpromazine is actively transported my P-glycoprotein and that chemosensitization by phenothiazines may occur by competition of these agents for active transport of anticancer agents by P-glycoprotein.	Phenothiazines	124-138	ATP binding cassette subfamily B member 1	Homo sapiens	225-239
8669819-4	1995	Active benzo[a]phenothiazines induced DNA fragmentation in four human myelogenous leukaemic cell lines (HL-60, ML-1, U-937, THP-1), but not in human T-cell leukaemic MOLT-4 and erythroleukaemic K-562 cell lines, which were also resistant to other apoptosis-inducing agents.	Phenothiazines	15-29	interleukin 17F	Homo sapiens	111-122
8669819-4	1995	Active benzo[a]phenothiazines induced DNA fragmentation in four human myelogenous leukaemic cell lines (HL-60, ML-1, U-937, THP-1), but not in human T-cell leukaemic MOLT-4 and erythroleukaemic K-562 cell lines, which were also resistant to other apoptosis-inducing agents.	Phenothiazines	15-29	GLI family zinc finger 2	Homo sapiens	124-129
7738403-0	1995	Inhibition of radiation-induced changes of glyoxalase I activity in mouse spleen and liver by phenothiazines.	Phenothiazines	94-108	glyoxalase 1	Mus musculus	43-55
8974453-0	1995	Synthesis, binding affinity, and cross-linking of monodentate photoactive phenothiazines to calmodulin.	Phenothiazines	74-88	calmodulin 1	Homo sapiens	92-102
8974453-2	1995	These phenothiazines were evaluated for their ability to inhibit the calmodulin-mediated activation of phosphodiesterase (PDE).	Phenothiazines	6-20	calmodulin 1	Homo sapiens	69-79
8974455-1	1995	The development of targeted, bidentate photoaffinity reagents for mapping the interacting domains of calmodulin (CaM) with the enzymes that it regulates required the synthesis and evaluation of the binding affinity of various phenothiazines.	Phenothiazines	226-240	calmodulin 3	Homo sapiens	101-111
8974455-1	1995	The development of targeted, bidentate photoaffinity reagents for mapping the interacting domains of calmodulin (CaM) with the enzymes that it regulates required the synthesis and evaluation of the binding affinity of various phenothiazines.	Phenothiazines	226-240	calmodulin 3	Homo sapiens	113-116
8974455-5	1995	The phenothiazines that possessed photoactive 3-azido and benzophenone groups and in which one of the piperazine nitrogens in the side chain was converted to a quaternary, N-methylammonium iodide inhibited the calmodulin-mediated activation of phosphodiesterase at a level comparable to that of chlorpromazine.	Phenothiazines	4-18	calmodulin 3	Homo sapiens	210-220
8529475-3	1995	Several non-cancer therapy drugs (e.g., verapamil, phenothiazines) compete for the p-glycoprotein pump and thus can block efflux of a chemotherapeutic agent and overcome cellular resistance.	Phenothiazines	51-65	ATP binding cassette subfamily B member 1	Homo sapiens	83-97
7616103-1	1995	The phenothiazines are known to be potent inhibitors of calmodulin and have been used as probes for examining calmodulin-dependent cellular functions.	Phenothiazines	4-18	calmodulin 1	Homo sapiens	56-66
7616103-1	1995	The phenothiazines are known to be potent inhibitors of calmodulin and have been used as probes for examining calmodulin-dependent cellular functions.	Phenothiazines	4-18	calmodulin 1	Homo sapiens	110-120
7616103-3	1995	Ca(2+)-dependent aggregation of liposomes mediated by either annexin I or annexin II was inhibited by the phenothiazines.	Phenothiazines	106-120	annexin A2	Homo sapiens	74-84
7738403-4	1995	Phenothiazines such as chlorpromazine (CPZ), promethazine (PMZ) and trimeprazine (TMZ) inhibited the radiation-enhanced activity of GI in a concentration-dependent manner.	Phenothiazines	0-14	glyoxalase 1	Mus musculus	132-134