PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8227013-1	1993	Chloramphenicol acetyltransferase (CAT, EC 2.3.1.28) is a bacterial chloramphenicol resistance marker that is commonly used as a reporter enzyme in gene expression studies and as a carrier protein for the production of fused peptides.	Chloramphenicol	68-83	chloramphenicol acetyltransferase	Escherichia coli	0-33
8263600-7	1993	In rats of both genotypes, the activity and hepatic concentration of chloramphenicol-UDPGT mRNA and liver and urine ascorbic acid concentration were increased by sodium phenobarbital.	Chloramphenicol	69-84	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	85-90
8263600-8	1993	The data indicate that the stimulation of the expression of both the 4-nitrophenol and chloramphenicol UDPGT genes plays a key role in the ascorbic acid biosynthesis induced by 3MC and sodium phenobarbital.	Chloramphenicol	87-102	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	103-108
8122034-2	1993	Glyoxalase I is competitively inhibited by sulphadimidine, oxytetracycline, chloramphenicol, etc.	Chloramphenicol	76-91	glyoxalase I	Homo sapiens	0-12
8227013-1	1993	Chloramphenicol acetyltransferase (CAT, EC 2.3.1.28) is a bacterial chloramphenicol resistance marker that is commonly used as a reporter enzyme in gene expression studies and as a carrier protein for the production of fused peptides.	Chloramphenicol	68-83	chloramphenicol acetyltransferase	Escherichia coli	35-38
8284502-5	1993	The beta-lactamase from the C freundii had a pI of 5.2 and was encoded on a 75 Kbp plasmid which also mediated resistance to trimethoprim, chloramphenicol, apramycin, gentamicin and tobramycin.	Chloramphenicol	139-154	kinesin family binding protein	Bos taurus	79-82
8293959-2	1993	To characterize the aadK gene, we constructed a B. subtilis 168 strain that carried the chloramphenicol resistance gene near the aadK on the chromosome and an aadK deletion mutant using an integration technique.	Chloramphenicol	88-103	aminoglycoside 6-adenylyltransferase	Bacillus subtilis subsp. subtilis str. 168	20-24
8293959-2	1993	To characterize the aadK gene, we constructed a B. subtilis 168 strain that carried the chloramphenicol resistance gene near the aadK on the chromosome and an aadK deletion mutant using an integration technique.	Chloramphenicol	88-103	aminoglycoside 6-adenylyltransferase	Bacillus subtilis subsp. subtilis str. 168	129-133
8293959-2	1993	To characterize the aadK gene, we constructed a B. subtilis 168 strain that carried the chloramphenicol resistance gene near the aadK on the chromosome and an aadK deletion mutant using an integration technique.	Chloramphenicol	88-103	aminoglycoside 6-adenylyltransferase	Bacillus subtilis subsp. subtilis str. 168	129-133
8331072-4	1993	When carried on plasmid pRIC1013, the sigma 54-CAT fusion expressed chloramphenicol resistance in Escherichia coli, and CAT production was affected by the pH of the growth medium, the composition of the growth atmosphere, and the growth temperature, with production being significantly higher at 42 degrees C. A conjugative suicide vector, pRIC1028, containing the sigma 54-CAT fusion was constructed and used to recombine the flaB-CAT fusion back into the C. coli chromosome in the correct position with respect to the flaA gene and its transcription terminator.	Chloramphenicol	68-83	chloramphenicol acetyltransferase	Escherichia coli	47-50
8238361-11	1993	Caco-2 cells transfected with 5" flanking regions of the human Na(+)-K(+)-ATPase beta 1-gene linked to the chloramphenicol acetyltransferase (CAT) reporter gene responded to 3,5,3"-triiodothyronine (T3) treatment with increased expression of CAT activity.	Chloramphenicol	107-122	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	81-87
8262596-16	1993	Chloromycetin, gentamicin and penicillin were the main culprits responsible for AAC.	Chloramphenicol	0-13	glycine-N-acyltransferase	Homo sapiens	80-83
8369283-1	1993	The compatible plasmids pKGP1-1 and pCM-X# will confer chloramphenicol resistance to Escherichia coli harboring the two plasmids if the T7 RNA polymerase produced from pKGP1-1 can recognize the T7 promoter carried on pCM-X# and transcribe the CAT gene that is cloned behind the promoter [Ikeda et al.	Chloramphenicol	55-70	chloramphenicol acetyltransferase	Escherichia coli	243-246
8369283-5	1993	It was established that E. coli harboring the mutant plasmid pKGP-HA1mut4 and an inactive pCM-X# are chloramphenicol-resistant and that the mutation responsible for the expression of CAT from the inactive pCM-X# plasmid is a G to A transition at nucleotide 664 of T7 gene 1 that converts glutamic acid (222) to lysine.	Chloramphenicol	101-116	chloramphenicol acetyltransferase	Escherichia coli	183-186
8476412-3	1993	Using a chloramphenicol acetyltransferase (CAT) assay, a number of cellular and viral promoters were transactivated by DA2-6, and the spectrum of transactivational effect was the same as that by the wild type X gene of the virus.	Chloramphenicol	8-23	piezo type mechanosensitive ion channel component 2	Homo sapiens	119-124
8388372-4	1993	Analysis of chloramphenicol acetyltransferase (CAT) mRNA produced by constructs containing the PAI-1 promoter (-805 to +83) showed that the deletion allele produced six times more mRNA than the insertion allele in response to interleukin-1 (p < 0.001).	Chloramphenicol	12-27	serpin family E member 1	Homo sapiens	95-100
8321221-5	1993	Both transient and stable transfection experiments show that AP-2B inhibits AP-2 transactivator function, as measured by an AP-2-responsive chloramphenicol acetyltransferase reporter plasmid.	Chloramphenicol	140-155	transcription factor AP-2 beta	Homo sapiens	61-66
8321221-5	1993	Both transient and stable transfection experiments show that AP-2B inhibits AP-2 transactivator function, as measured by an AP-2-responsive chloramphenicol acetyltransferase reporter plasmid.	Chloramphenicol	140-155	transcription factor AP-2 alpha	Homo sapiens	61-65
8321221-5	1993	Both transient and stable transfection experiments show that AP-2B inhibits AP-2 transactivator function, as measured by an AP-2-responsive chloramphenicol acetyltransferase reporter plasmid.	Chloramphenicol	140-155	transcription factor AP-2 alpha	Homo sapiens	76-80
1285126-6	1992	The injection of a chloramphenicol acetyl transferase (CAT)-Cl2 chimeric RNA into fertilized eggs not only results in embryonic polyadenylation of the transcript but also 5- to 15-fold more CAT activity compared with eggs injected with CAT RNA or CAT-Cl2 chimeric RNA that is prevented from undergoing poly(A) elongation by a mutation in the polyadenylation hexanucleotide.	Chloramphenicol	19-34	limb bud and heart development L homeolog	Xenopus laevis	60-63
1369494-7	1992	The groES and groEL genes of B. subtilis were physically mapped on the 60 degrees region of a 360 degrees map and genetically mapped at the position of 40% linkage with the purB locus using PBS1 transduction of the groEL genes tagged with a chloramphenicol resistance (chlr) marker.	Chloramphenicol	241-256	chaperonin GroES	Escherichia coli	4-9
1369494-7	1992	The groES and groEL genes of B. subtilis were physically mapped on the 60 degrees region of a 360 degrees map and genetically mapped at the position of 40% linkage with the purB locus using PBS1 transduction of the groEL genes tagged with a chloramphenicol resistance (chlr) marker.	Chloramphenicol	241-256	GroEL	Escherichia coli	14-19
8380784-7	1993	Tn1739tnpR is a derivative of Tn1721 with a chloramphenicol-resistance-encoding gene (CmR), the lambda cI repressor gene, and a further copy of the resolvase-encoding tnpR gene under control of the tac promoter.	Chloramphenicol	44-59	transposon Tn3 resolvase	Escherichia coli	6-10
1285126-6	1992	The injection of a chloramphenicol acetyl transferase (CAT)-Cl2 chimeric RNA into fertilized eggs not only results in embryonic polyadenylation of the transcript but also 5- to 15-fold more CAT activity compared with eggs injected with CAT RNA or CAT-Cl2 chimeric RNA that is prevented from undergoing poly(A) elongation by a mutation in the polyadenylation hexanucleotide.	Chloramphenicol	19-34	limb bud and heart development L homeolog	Xenopus laevis	251-254
1461942-1	1992	We have sequenced the chloramphenicol resistance determinant (cat) of plasmid pIP501 from Streptococcus agalactiae to investigate its relationship with other cognate cat determinants.	Chloramphenicol	22-37	chloramphenicol acetyltransferase	Streptococcus agalactiae	62-65
1415722-3	1992	In isolated, blood-perfused rat lungs, 1-ABT (0.5 mg/ml) and chloramphenicol (1 mg/ml) inhibited lung microsomal cytochrome P-450 (ethoxycoumarin O-deethylase) activity to 24 and 44% of control, respectively, and blunted hypoxia and angiotensin II-induced vasoconstriction.	Chloramphenicol	61-76	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	113-129
1415722-3	1992	In isolated, blood-perfused rat lungs, 1-ABT (0.5 mg/ml) and chloramphenicol (1 mg/ml) inhibited lung microsomal cytochrome P-450 (ethoxycoumarin O-deethylase) activity to 24 and 44% of control, respectively, and blunted hypoxia and angiotensin II-induced vasoconstriction.	Chloramphenicol	61-76	angiotensinogen	Rattus norvegicus	233-247
1809841-1	1991	The expression of the chloramphenicol-inducible chloramphenicol-acetyltransferase gene (cat), encoded on Staphylococcus aureus plasmid pUB112, is regulated via a translational attenuation mechanism.	Chloramphenicol	22-37	CAT	Staphylococcus aureus	48-81
24201588-5	1992	The induction of GUS activity in the bacteria can be inhibited by chloramphenicol, tetracycline, ticarcillin and sodium azide.	Chloramphenicol	66-81	glucuronidase beta	Homo sapiens	17-20
1319843-2	1992	We demonstrate that disruption of PDR5 causes marked hypersensitivity not only to cycloheximide but also to sulphometuron methyl and the mitochondrial inhibitors chloramphenicol, lincomycin, erythromycin and antimycin.	Chloramphenicol	162-177	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	34-38
1566760-8	1992	RESULTS: The chloramphenicol acetyltransferase assays reveal that in the absence of estradiol low levels of conversion of chloramphenicol to acetylated products occur when the mutant estrogen receptor is used to activate chloramphenicol acetyltransferase gene transcription, supporting that it has some constitutive function.	Chloramphenicol	13-28	estrogen receptor 1	Homo sapiens	183-200
1517170-1	1992	The 4.6 kb chloramphenicol resistance (Cm) plasmid, pSCS6, isolated from a naturally occurring Staphylococcus aureus biotype C encoded an inducible chloramphenicol acetyltransferase (CAT).	Chloramphenicol	11-26	CAT	Staphylococcus aureus	148-181
1517170-1	1992	The 4.6 kb chloramphenicol resistance (Cm) plasmid, pSCS6, isolated from a naturally occurring Staphylococcus aureus biotype C encoded an inducible chloramphenicol acetyltransferase (CAT).	Chloramphenicol	11-26	CAT	Staphylococcus aureus	183-186
1564439-1	1992	The two 4.6 kb chloramphenicol resistance (CmR) plasmids pSCS6 and pSCS7, previously identified in Staphylococcus aureus from subclinical bovine mastitis, both encoded an inducible chloramphenicol acetyltransferase (CAT, EC 2.3.1.28).	Chloramphenicol	15-30	CAT	Staphylococcus aureus	181-214
1929328-5	1991	Two other E. coli HB101 transconjugants obtained from K. pneumoniae, selected on gentamicin or chloramphenicol, showed that TEM-1 and gentamicin resistance could be encoded either by a greater than 150-kb Inc6 or C plasmid or by an 85-kb Inc7 or M plasmid.	Chloramphenicol	95-110	beta-lactamase	Klebsiella pneumoniae	124-129
1769526-1	1991	A 5.1-kb plasmid, designated pSCS12, isolated from a naturally occurring Staphylococcus sciuri conferred resistance to chloramphenicol (CmR) and streptomycin (SmR).	Chloramphenicol	119-134	multidrug resistance efflux protein Smr	Staphylococcus aureus	159-162
1929282-8	1991	CAT from pSCS5 exhibited Km values of 2.81 and 51.8 microM for chloramphenicol and acetyl coenzyme A, respectively.	Chloramphenicol	63-78	chloramphenicol acetyltransferase	Escherichia coli	0-3
1645787-3	1991	A series of deletion plasmids encompassing positions -551 to +14 of the BZLF1 promoter region were constructed and tested for the ability to drive chloramphenicol acetyltransferase (CAT) gene expression in the absence of inducing agents such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and anti-immunoglobulin.	Chloramphenicol	147-162	protein Zta	Human gammaherpesvirus 4	72-77
1906977-3	1991	The 4-HBP UDPGT was shown to catalyze the glucuronidation of 4-HBP, 4-methylumbelliferone, and p-nitrophenol but did not react with testosterone, androsterone, morphine, chloramphenicol, 4-hydroxycoumarin, or 7-methoxycoumarin.	Chloramphenicol	170-185	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	10-15
1906977-7	1991	This work describes the purification and characterization of a 4-HBP UDPGT from rat liver microsomes and, furthermore, provides evidence that suggests that this UDPGT is different from another UDPGT previously shown to react with 4-HBP and chloramphenicol.	Chloramphenicol	240-255	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	69-74
1906977-7	1991	This work describes the purification and characterization of a 4-HBP UDPGT from rat liver microsomes and, furthermore, provides evidence that suggests that this UDPGT is different from another UDPGT previously shown to react with 4-HBP and chloramphenicol.	Chloramphenicol	240-255	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	161-166
1906977-7	1991	This work describes the purification and characterization of a 4-HBP UDPGT from rat liver microsomes and, furthermore, provides evidence that suggests that this UDPGT is different from another UDPGT previously shown to react with 4-HBP and chloramphenicol.	Chloramphenicol	240-255	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	161-166
34943759-13	2021	Among these are acquired AMR determinants including fluoroquinolone resistance-conferring genes aac(3)-Ib-cr and other significant genes: aad, tet, sul1, sul2, and cat, which are associated with aminoglycoside, tetracycline, sulfonamide, and chloramphenicol resistance, respectively.	Chloramphenicol	242-257	dihydropteroate synthase	Escherichia coli	148-152
1706702-8	1991	Expression of the CAT gene was demonstrated by acetylation of chloramphenicol by cell-free extracts from the transfected spiroplasmas.	Chloramphenicol	62-77	chloramphenicol acetyltransferase	Escherichia coli	18-21
1847347-3	1991	The bla gene was replaced in some plasmids by the cat gene of Tn9 coding for chloramphenicol resistance, extending the use into beta-lactam-resistant strains.	Chloramphenicol	77-92	beta-lactamase	Escherichia coli	4-7
33773789-12	2021	The genes tetA, sul2, and floR were the most frequently observed AMR genes in K. pneumoniae resistant to tetracycline, sulfamethoxazole-trimethoprim, and chloramphenicol, respectively.	Chloramphenicol	154-169	Florfenicol/Chloramphenicol efflux protein	Klebsiella pneumoniae	26-30
2059915-0	1991	Porphyrinogenic effects in chick embryo liver cell culture of chloramphenicol analogues that are mechanism-based inactivators of cytochrome P-450.	Chloramphenicol	62-77	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	129-145
2059915-1	1991	Structural analogues of chloramphenicol (CAP) cause mechanism-based inactivation of rat liver cytochrome P-450 (P450) either via protein acylation or destruction of the heme prosthetic group.	Chloramphenicol	24-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	94-110
2059915-1	1991	Structural analogues of chloramphenicol (CAP) cause mechanism-based inactivation of rat liver cytochrome P-450 (P450) either via protein acylation or destruction of the heme prosthetic group.	Chloramphenicol	41-44	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	94-110
16667961-5	1991	In the presence of chloramphenicol, both GDH activity and protein level in the cells were considerably reduced, suggesting that this enzyme was synthesized in organelles and not in the cytosol.	Chloramphenicol	19-34	glutamate dehydrogenase 1	Homo sapiens	41-44
2264572-3	1990	In the present study, we found that increasing concentrations of rhGM-CSF or rhG-CSF completely reversed the inhibitory effect of CAP (2 x 10(-4) M) on human CFU-GM growth and on the growth of KG-1 cells.	Chloramphenicol	130-133	colony stimulating factor 2	Homo sapiens	70-73
2264572-3	1990	In the present study, we found that increasing concentrations of rhGM-CSF or rhG-CSF completely reversed the inhibitory effect of CAP (2 x 10(-4) M) on human CFU-GM growth and on the growth of KG-1 cells.	Chloramphenicol	130-133	colony stimulating factor 2	Homo sapiens	81-84
2210524-2	1990	Increases in serum alanine aminotransferase and aspartate aminotransferase activities as a result of oral administration of 320 mg geniposide/kg body weight were suppressed when geniposide was administered ip or when the rats were pretreated with chloramphenicol.	Chloramphenicol	247-262	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	48-74
18592563-8	1990	Furthermore, the induction of CAT, mediated by the presence of chloramphenicol, is shown to occur only at low growth rates, which further increases the metabolic load.Results are vdelineated with the aid of a structured kinetic model representing the metabolism of recombinant E. coli.	Chloramphenicol	63-78	chloramphenicol acetyltransferase	Escherichia coli	30-33
2317370-0	1990	Use of a fluorescent chloramphenicol derivative as a substrate for CAT assays.	Chloramphenicol	21-36	catalase	Homo sapiens	67-70
2406724-8	1990	Transformation of E. coli with the resultant CATam1.2.5 gene yielded transformants that synthesized CAT polypeptide and were resistant to chloramphenicol only when they were also transformed with the mutant tRNA(fMetCUA) gene.	Chloramphenicol	138-153	chloramphenicol acetyltransferase	Escherichia coli	45-48
24487082-4	1990	Other drugs, such as chloramphenicol, propoxyphene, verapamil, and viloxazine, inhibit cytochrome P-450.	Chloramphenicol	21-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	87-103
2091255-2	1990	Review of recent data from the USA and Europe indicates that delayed CSF sterilization occurs significantly more often with ampicillin/chloramphenicol and cefuroxime than with ceftriaxone and cefotaxime.	Chloramphenicol	135-150	colony stimulating factor 2	Homo sapiens	69-72
33811389-7	2021	CONCLUSIONS: Extended-spectrum beta-lactamases-producing E. coli blaCTX-M-15 with plasmid genes show significantly higher resistant rates against piperacillin-tazobactam but lower resistant rates against chloramphenicol compared to chromosomal strains in Indonesian patients with urinary tract infection.	Chloramphenicol	204-219	beta-lactamase	Escherichia coli	65-76
33233093-10	2020	Twenty-six unique antimicrobial-resistance genes were identified with blaTEM-1A and blaTEM-1B likely responsible for most beta-lactam resistance and floR responsible for most chloramphenicol resistance.	Chloramphenicol	175-190	Beta-lactamase TEM_1	Salmonella enterica subsp. enterica serovar Typhimurium	84-93
34694885-5	2022	Introducing the ramAp and the truncated ISEcp1 into E. coli have resulted in elevated expression of efflux pump genes and elevated MICs to chloramphenicol, azithromycin, nalidixic acid, ciprofloxacin, sulfamethoxazole, trimethoprim, tetracycline, and tigecycline.	Chloramphenicol	139-154	ISEcp1	Escherichia coli	40-46
34943759-13	2021	Among these are acquired AMR determinants including fluoroquinolone resistance-conferring genes aac(3)-Ib-cr and other significant genes: aad, tet, sul1, sul2, and cat, which are associated with aminoglycoside, tetracycline, sulfonamide, and chloramphenicol resistance, respectively.	Chloramphenicol	242-257	dihydropteroate synthase protein Sul2	Escherichia coli	154-158
34425756-10	2021	Fluoroquinolone-resistance conferring substitutions in gyrA + parC were detected in 9 (27.3 %) isolates and chloramphenicol resistance was predicted from presence of aac6"-aph2 gene in 11 (33.3 %).	Chloramphenicol	108-123	zinc finger DHHC-type palmitoyltransferase 16	Homo sapiens	172-176
34599943-0	2021	Split chloramphenicol acetyl-transferase assay reveals self-ubiquitylation-dependent regulation of UBE3B.	Chloramphenicol	6-21	ubiquitin protein ligase E3B	Homo sapiens	99-104
34599943-3	2021	Here we present a newly developed split chloramphenicol acetyltransferase (split-CAT) -based genetic selection system.	Chloramphenicol	40-55	catalase	Homo sapiens	81-84
34314962-3	2021	The adsorption capacity of amphenicol antibiotics in the soil was weak, and the Kf value was in the range of 0.15-3.59 mug1-1/nL1/n kg-1.	Chloramphenicol	27-37	neuroligin 1	Homo sapiens	126-136
34537657-6	2021	This C18-CDs/SiO2 column was applied for the fast detection of chloramphenicol in milk without complex sample pretreatment process.	Chloramphenicol	63-78	Bardet-Biedl syndrome 9	Homo sapiens	5-8
34387504-0	2021	Catalytic Syn-Selective Nitroaldol Approach to Amphenicol Antibiotics: Evolution of a Unified Asymmetric Synthesis of (-)-Chloramphenicol, (-)-Azidamphenicol, (+)-Thiamphenicol, and (+)-Florfenicol.	Chloramphenicol	47-57	synemin	Homo sapiens	10-13
34387504-0	2021	Catalytic Syn-Selective Nitroaldol Approach to Amphenicol Antibiotics: Evolution of a Unified Asymmetric Synthesis of (-)-Chloramphenicol, (-)-Azidamphenicol, (+)-Thiamphenicol, and (+)-Florfenicol.	Chloramphenicol	118-137	synemin	Homo sapiens	10-13
34387504-1	2021	A unified strategy for an efficient and high diastereo- and enantioselective synthesis of (-)-chloramphenicol, (-)-azidamphenicol, (+)-thiamphenicol, and (+)-florfenicol based on a key catalytic syn-selective Henry reaction is reported.	Chloramphenicol	90-109	synemin	Homo sapiens	195-198
35269699-3	2022	Results demonstrated that SB-1 showed an antibacterial activity determined by the minimal inhibitory concentration (MIC) against Staphylococcus aureus, Enterococcus faecalis, and Bacillus cereus (Gram-positive bacteria involved in human and animal diseases such as skin infections, pneumonia, diarrheal syndrome, and urinary tract infections, among others), which was similar to that shown by the classical antibiotic chloramphenicol.	Chloramphenicol	418-433	SH3KBP1 binding protein 1	Homo sapiens	26-30
34075502-10	2021	The results show a direct effect of the broad-spectrum antibiotic chloramphenicol on the passive elasticity of muscle protein titin.	Chloramphenicol	66-81	titin	Homo sapiens	126-131
35174380-5	2022	The selected linear range for each analyte is as follows: 5-200 ng mL-1 for ampicillin; 0.1-200 ng mL-1 for amoxicillin and chloramphenicol; and 1-200 ng mL-1 for enrofloxacin and oxytetracycline, respectively.	Chloramphenicol	124-139	L1 cell adhesion molecule	Mus musculus	99-103
35069492-1	2021	The prototype fexA gene confers combined resistance to chloramphenicol and florfenicol.	Chloramphenicol	55-70	FexA	Staphylococcus aureus	14-18
35065505-9	2022	The association (P < 0.05) was found between mtDNA methylation level (MT-ATP8 and MT-ND5) and individual antibiotics including chlorpromazine, ciprofloxacin, enrofloxacin, norfloxacin, pefloxacin, sulfaquinoxaline, sulfachloropyridazine, chloramphenicol, and thiamphenicol, indicating that persistent exposure to low-dose multiple antibiotics may affect the mtDNA methylation level and in turn pose health risks.	Chloramphenicol	238-253	mitochondrially encoded ATP synthase 8	Homo sapiens	73-77
35065505-9	2022	The association (P < 0.05) was found between mtDNA methylation level (MT-ATP8 and MT-ND5) and individual antibiotics including chlorpromazine, ciprofloxacin, enrofloxacin, norfloxacin, pefloxacin, sulfaquinoxaline, sulfachloropyridazine, chloramphenicol, and thiamphenicol, indicating that persistent exposure to low-dose multiple antibiotics may affect the mtDNA methylation level and in turn pose health risks.	Chloramphenicol	238-253	mitochondrially encoded NADH dehydrogenase 5	Homo sapiens	82-88
35225760-17	2022	Furthermore, E. coli from the neonates carried a chloramphenicol resistance gene (catB3), also on the IncFIA plasmid.	Chloramphenicol	49-64	chloramphenicol acetyltransferase	Escherichia coli	82-87
34935812-6	2022	Furthermore, the synergism between Ru2 and common antibiotics, such as ampicillin, chloramphenicol, tetracyclines and ofloxacin, against S. aureus was also detected using the checkerboard method.	Chloramphenicol	83-98	doublecortin domain containing 2a	Mus musculus	35-38
35069492-2	2021	However, fexA variants mediating resistance only to chloramphenicol have been identified, such as in the case of a Staphylococcus aureus isolate recovered from poultry meat illegally imported to Germany.	Chloramphenicol	52-67	FexA	Staphylococcus aureus	9-13
2682205-9	1989	Thus, the lowering of the kcat of peptidyltransferase induced by chloramphenicol (from 0.91 to 0.34 min-1) can occur irrespective of the activity status of peptidyltransferase.	Chloramphenicol	65-80	CD59 molecule (CD59 blood group)	Homo sapiens	100-105
2628543-1	1989	A new bromoperoxidase-catalase was purified from the chloramphenicol-producing actinomycete Streptomyces venezuelae ISP 5230.	Chloramphenicol	53-68	SVEN_RS24125	Streptomyces venezuelae ATCC 10712	6-30
2668528-2	1989	The products of chloramphenicol inactivation by chloramphenicol acetyltransferase (CAT) were identified by high performance liquid chromatography.	Chloramphenicol	16-31	chloramphenicol acetyltransferase II	Haemophilus influenzae	48-81
2628543-8	1989	The bromoperoxidase-catalase was not present in active form in a mutant of S. venezuelae ISP 5230, blocked in the chlorination step of chloramphenicol biosynthesis.	Chloramphenicol	135-150	SVEN_RS24125	Streptomyces venezuelae ATCC 10712	4-28
2668528-2	1989	The products of chloramphenicol inactivation by chloramphenicol acetyltransferase (CAT) were identified by high performance liquid chromatography.	Chloramphenicol	16-31	chloramphenicol acetyltransferase II	Haemophilus influenzae	83-86
2668528-3	1989	The sole product in H. influenzae is a single monoacetyl compound, whereas variants of CAT isolated from other chloramphenicol-resistant bacteria usually produce both monoacetyl and diacetyl chloramphenicol metabolites.	Chloramphenicol	111-126	chloramphenicol acetyltransferase II	Haemophilus influenzae	87-90
2725317-2	1989	We suspect that the deacetylase activity is the most important, as the extract of the H4IIE C3 cells was capable of completely deacetylating the mono- and diacetylchloramphenicol formed during a 2-hr incubation of CAT with chloramphenicol and acetyl-CoA.	Chloramphenicol	163-178	catalase	Rattus norvegicus	214-217
2798536-6	1989	Mitochondrial PS was inhibited with chloramphenicol (CAP-1.5 mg intracisternally).	Chloramphenicol	36-51	cyclase associated actin cytoskeleton regulatory protein 1	Rattus norvegicus	53-58
2660105-2	1989	This was accomplished by using a bacteriophage f1 vector containing a fusion of the mutant E. coli lac promoters with the structural gene for chloramphenicol acetyltransferase (CAT), so that a system was provided for selecting phage revertants (or pseudorevertants) that conferred resistance of phage-infected cells to chloramphenicol.	Chloramphenicol	142-157	chloramphenicol acetyltransferase	Escherichia coli	177-180
2469744-3	1989	Chloramphenicol, which inhibits mitochondrial protein synthesis, suppressed IFN effect when present in high concentration; in human foreskin cells, the inhibitory effect on HuIFN-alpha activity of 500 micrograms/ml chloramphenicol (which caused only 20% inhibition of overall cellular protein synthesis) was greater than that observed with 25 micrograms/ml cycloheximide (which caused 98% inhibition of overall cellular protein synthesis).	Chloramphenicol	0-15	interferon alpha 1	Homo sapiens	76-79
2469744-3	1989	Chloramphenicol, which inhibits mitochondrial protein synthesis, suppressed IFN effect when present in high concentration; in human foreskin cells, the inhibitory effect on HuIFN-alpha activity of 500 micrograms/ml chloramphenicol (which caused only 20% inhibition of overall cellular protein synthesis) was greater than that observed with 25 micrograms/ml cycloheximide (which caused 98% inhibition of overall cellular protein synthesis).	Chloramphenicol	215-230	interferon alpha 1	Homo sapiens	76-79
2469744-4	1989	Cycloheximide combined with chloramphenicol further inhibited the antiviral effect of IFN than that observed by either drug alone.	Chloramphenicol	28-43	interferon alpha 1	Homo sapiens	86-89
3266622-8	1988	Rare chloramphenicol-resistant, CAT-negative strains have been described in the USA and these strains would only be detected by a disc diffusion or MIC test.	Chloramphenicol	5-20	chloramphenicol acetyltransferase II	Haemophilus influenzae	32-35
3072245-4	1988	At rapid bacterial growth rate, chloramphenicol slightly stabilises both the bla and ompA transcripts without affecting their characteristic difference in half-life.	Chloramphenicol	32-47	beta-lactamase	Escherichia coli	77-80
3265360-7	1988	Cephalothin, chloramphenicol and gentamicin decreased IL-2 production by mouse spleen cells in vitro.	Chloramphenicol	13-28	interleukin 2	Mus musculus	54-58
3148707-4	1988	Treatments with m- and o-DCBs, 1,2,4-TCB and 2,4,5-TCPSO2Me enhanced UDPGT activities toward both chloramphenicol (CP) and p-nitrophenol (NP).	Chloramphenicol	98-113	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	69-74
2465483-1	1988	The expression of the chloramphenicol (Cm) - inducible Cm acetyltransferase gene (cat) of the staphylococcal plasmid pUB112 is regulated at the translational level.	Chloramphenicol	22-37	chloramphenicol acetyltransferase	Staphylococcus aureus	55-75
3264562-0	1988	Meningitis due to beta-lactamase producing chloramphenicol resistant Haemophilus influenzae type b in Kuwait.	Chloramphenicol	43-58	beta-lactamase TEM-1	Haemophilus influenzae	18-32
2465483-1	1988	The expression of the chloramphenicol (Cm) - inducible Cm acetyltransferase gene (cat) of the staphylococcal plasmid pUB112 is regulated at the translational level.	Chloramphenicol	22-37	chloramphenicol acetyltransferase	Staphylococcus aureus	82-85
3395379-0	1988	Effect of chloramphenicol administration in vivo on cytochrome P-450-dependent monooxygenase activities in liver microsomes from uninduced male rats.	Chloramphenicol	10-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	52-68
3134892-5	1988	Chloramphenicol, 4-hydroxybiphenyl, 4-methylumbelliferone, 1-naphthol and 4-nitrophenol were all shown to inhibit the low affinity morphine-UDPGT activity, but only chloramphenicol and 1-naphthol were competitive inhibitors.	Chloramphenicol	0-15	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	140-145
3134892-5	1988	Chloramphenicol, 4-hydroxybiphenyl, 4-methylumbelliferone, 1-naphthol and 4-nitrophenol were all shown to inhibit the low affinity morphine-UDPGT activity, but only chloramphenicol and 1-naphthol were competitive inhibitors.	Chloramphenicol	165-180	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	140-145
2893712-1	1987	The effectiveness, selectivity, and mechanism of the inactivation of the major beta-naphthoflavone-inducible isozyme of rat liver cytochrome P-450 (BNF-B) by the chloramphenicol analog N-(2-p-nitrophenethyl)dichloroacetamide (pNO2DCA) have been investigated.	Chloramphenicol	162-177	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	130-146
2458501-11	1988	In two further patients with confirmed central nervous system involvement at diagnosis, who were treated with ampicillin plus chloramphenicol, characteristic SPC cells disappeared from the cerebrospinal fluid.	Chloramphenicol	126-141	proline rich protein gene cluster	Homo sapiens	158-161
3124747-5	1988	Experiments with the highly purified cytochrome P-450 isozyme LM2, in which amino acid residue(s) close to the heme edge had undergone suicidal inactivation through covalent attachment of chloramphenicol metabolite(s) do not exclude the possibility that cytochrome b5 and reductase might compete for a common electron transmission site on the terminal acceptor.	Chloramphenicol	188-203	cytochrome P-450	Oryctolagus cuniculus	37-53
2893712-0	1987	Mechanism-based inactivation of the major beta-naphthoflavone-inducible isozyme of rat liver cytochrome P-450 by the chloramphenicol analog N-(2-p-nitrophenethyl)dichloroacetamide.	Chloramphenicol	117-132	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	93-109
2457777-2	1988	The expression of a 35 kD hybrid lac Z"- alpha-fetoprotein polypeptide in Escherichia coli was demonstrated by the chloramphenicol release assay and by immunoprecipitation using rabbit anti-mouse alpha-fetoprotein antibodies as probe.	Chloramphenicol	115-130	alpha fetoprotein	Mus musculus	41-58
3336347-6	1988	Based on these data, 12 chloramphenicol analogs were examined, and the results with these compounds show that their selectivity as cytochrome P-450 inactivators is a function of at least three structural features: 1) the number of halogen atoms, 2) the presence of a para-nitro group on the phenyl ring, and 3) substitutions on the ethyl side chain.	Chloramphenicol	24-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	131-147
2893713-0	1987	Selective inactivation by chloramphenicol of the major phenobarbital-inducible isozyme of dog liver cytochrome P-450.	Chloramphenicol	26-41	Cytochrome P450 1A1	Canis lupus familiaris	100-116
2893713-1	1987	Chloramphenicol (CAP) is a potent and effective mechanism-based inactivator of the major phenobarbital (PB)-inducible isozyme of dog liver cytochrome P-450 (PBD-2) in vitro.	Chloramphenicol	0-15	Cytochrome P450 1A1	Canis lupus familiaris	139-162
2893713-1	1987	Chloramphenicol (CAP) is a potent and effective mechanism-based inactivator of the major phenobarbital (PB)-inducible isozyme of dog liver cytochrome P-450 (PBD-2) in vitro.	Chloramphenicol	17-20	Cytochrome P450 1A1	Canis lupus familiaris	139-162
3624259-3	1987	Labeling in the presence of chloramphenicol during heat shock showed a similar heat shock protein pattern as in the absence of the inhibitor.	Chloramphenicol	28-43	heat shock 70 kDa protein	Zea mays	79-97
3112518-1	1987	The gene for chloramphenicol (Cm) acetyltransferase (CAT) carried by the staphylococcal plasmid pUB112, whose expression can be stimulated by Cm, is preceded by a regulatory region containing two control elements.	Chloramphenicol	13-28	chloramphenicol acetyltransferase	Staphylococcus aureus	53-56
3327915-1	1987	From the highly chloramphenicol-resistant cytophaga-like bacterium Flavobacterium CB60, which can both acetylate chloramphenicol and degrade it in co-metabolism, the chloramphenicol acetyltransferase (CAT) was purified to homogeneity and characterized.	Chloramphenicol	16-31	chloramphenicol acetyltransferase	Escherichia coli	166-199
3327915-1	1987	From the highly chloramphenicol-resistant cytophaga-like bacterium Flavobacterium CB60, which can both acetylate chloramphenicol and degrade it in co-metabolism, the chloramphenicol acetyltransferase (CAT) was purified to homogeneity and characterized.	Chloramphenicol	16-31	chloramphenicol acetyltransferase	Escherichia coli	201-204
3327915-1	1987	From the highly chloramphenicol-resistant cytophaga-like bacterium Flavobacterium CB60, which can both acetylate chloramphenicol and degrade it in co-metabolism, the chloramphenicol acetyltransferase (CAT) was purified to homogeneity and characterized.	Chloramphenicol	113-128	chloramphenicol acetyltransferase	Escherichia coli	166-199
3327915-1	1987	From the highly chloramphenicol-resistant cytophaga-like bacterium Flavobacterium CB60, which can both acetylate chloramphenicol and degrade it in co-metabolism, the chloramphenicol acetyltransferase (CAT) was purified to homogeneity and characterized.	Chloramphenicol	113-128	chloramphenicol acetyltransferase	Escherichia coli	201-204
3037367-5	1987	During chloramphenicol treatment, the rep-38 strain showed a larger amount of residual DNA synthesis than observed in the mmrA1 strain.	Chloramphenicol	7-22	replication protein	Escherichia coli	38-41
3110162-8	1987	Whereas both enzymes glucuronidated the endogenous steroids testosterone, dihydrotestosterone, and beta-estradiol, only UDPGTr-2 was active towards the foreign chemical substrates, chloramphenicol, 4-hydroxybiphenyl, and 4-methylumbelliferone.	Chloramphenicol	181-196	UDP glucuronosyltransferase family 2 member B17	Rattus norvegicus	120-128
3631932-2	1987	Irrespective of the isolation place, object and time, the NAG vibrios were highly resistant to penicillins and polymyxin M. At the same time they were highly sensitive to gentamicin (MIC 1-2 micrograms/ml), levomycetin (MIC 0.5-1 micrograms/ml) and tetracyclines (MIC 0.25-1 micrograms/ml).	Chloramphenicol	207-218	NBAS subunit of NRZ tethering complex	Homo sapiens	58-61
3035345-2	1987	To elucidate this polar effect, we constructed a plasmid which has an IS1 integrated between the 5" half of the tet gene for tetracycline resistance and the cat structural gene for chloramphenicol resistance.	Chloramphenicol	181-196	IS1	Homo sapiens	70-73
2882979-4	1987	It appears that chloramphenicol has a marked inhibitory effect on the activity of the cytochrome P-450-dependent mixed function oxidase liver microsome system responsible for the oxidation and demethylation of theophylline.	Chloramphenicol	16-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	86-102
3729972-3	1986	Microsomal monooxygenase heterogeneity is also shown to provide a plausible explanation of other published results signifying the departure of chloramphenicol and phenacetin from the concept of competitive inhibition despite competition with substrate for the active-site haem group of cytochrome P-450.	Chloramphenicol	143-158	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-24
3729972-3	1986	Microsomal monooxygenase heterogeneity is also shown to provide a plausible explanation of other published results signifying the departure of chloramphenicol and phenacetin from the concept of competitive inhibition despite competition with substrate for the active-site haem group of cytochrome P-450.	Chloramphenicol	143-158	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	286-302
3329042-2	1986	In the yeast Saccharomyces cerevisiae, two nuclear pleiotropic drug resistance mutations pdr3-1 (former designation mucPR) and pdr3-2 (former designation DRI9/T7) have been selected as resistant to mucidin and as resistant to chloramphenicol plus cycloheximide, respectively.	Chloramphenicol	226-241	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	89-93
2947760-1	1986	We report the immunological studies on three transplantable lymphoma lines that developed when CAF1 mice were injected with busulfan and chloramphenicol.	Chloramphenicol	137-152	chromatin assembly factor 1, subunit A (p150)	Mus musculus	95-99
3707122-11	1986	Reversal of the delayed-nodulation phenotype of HS111 through lectin pretreatment was prevented by chloramphenicol or rifampin.	Chloramphenicol	99-114	LOW QUALITY PROTEIN: lectin	Glycine max	62-68
3702858-0	1986	Analogues of chloramphenicol as mechanism-based inactivators of rat liver cytochrome P-450: modifications of the propanediol side chain, the p-nitro group, and the dichloromethyl moiety.	Chloramphenicol	13-28	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	74-90
3329042-2	1986	In the yeast Saccharomyces cerevisiae, two nuclear pleiotropic drug resistance mutations pdr3-1 (former designation mucPR) and pdr3-2 (former designation DRI9/T7) have been selected as resistant to mucidin and as resistant to chloramphenicol plus cycloheximide, respectively.	Chloramphenicol	226-241	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	127-131
3924914-0	1985	On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol.	Chloramphenicol	115-130	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	95-111
4033629-3	1985	Of eight major cytochrome P-450 isozymes which could be monitored in this fashion, three were inhibited by more than 50% by a dose of chloramphenicol of 300 mg/kg, whereas no evidence of inhibition of the remaining isozymes was obtained.	Chloramphenicol	134-149	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	15-31
4033629-4	1985	P-450PB-C, an isozyme which is present in significant amounts in untreated rats and which is induced approximately 2-fold by phenobarbital, was the most susceptible cytochrome P-450 to inhibition by chloramphenicol both in vivo and in vitro.	Chloramphenicol	199-214	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	165-181
4033629-5	1985	P-450PB-B, the major phenobarbital-inducible isozyme, and P-450UT-A, a male-specific testosterone 2 alpha- and 16 alpha-hydroxylase, were intermediate in their susceptibility to chloramphenicol.	Chloramphenicol	178-193	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	58-67
3160687-5	1985	The recombinase-defective mutants were much more sensitive than the recA+ strain to crystal violet, kanamycin, and chloramphenicol, indicating altered membrane permeability.	Chloramphenicol	115-130	recombinase	Escherichia coli	4-15
3924914-1	1985	The mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 (P-450 PB-B2) by chloramphenicol has been investigated.	Chloramphenicol	126-141	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	92-108
3924914-5	1985	The results are consistent with a scheme whereby the binding of metabolites of chloramphenicol to amino acid residues in the PB-B2 close to the heme moiety blocks electron transport from NADPH-cytochrome P-450 reductase, thereby leading to a loss of monooxygenase activity.	Chloramphenicol	79-94	cytochrome p450 oxidoreductase	Rattus norvegicus	187-219
4038400-6	1985	The labeling of P16 with [35S]methionine in primary rat hepatocyte cultures was inhibited by more than 90% by the cytoplasmic translation inhibitor cycloheximide, but unaffected by the mitochondrial-specific agent chloramphenicol.	Chloramphenicol	214-229	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	16-19
3932298-9	1985	faecium) streptococci, MLS resistance genes are also found on plasmids that carry other antibiotic resistance (tetracycline, chloramphenicol, high-levels of streptomycin and kanamycin).	Chloramphenicol	125-140	holocytochrome c synthase	Homo sapiens	23-26
3859734-1	1985	For large scale isolation of chloramphenicol acetyltransferase (CAT), five soil bacteria (Alkaligens faecalis cc; Escherichia coli c-18; Escherichia coli c-22; Escherichia coli c-24 and Klebsiella pneumoniae c-38) resistant to chloramphenicol (Cm) were tested with surface active agents such as sodium dodecyl sulphate (SDS), triton x-100, tween-80 and sodium deoxycholate (SDC).	Chloramphenicol	29-44	chloramphenicol acetyltransferase	Escherichia coli	64-67
2578570-7	1985	The addition of chloramphenicol subsequent to early enzyme synthesis prevented the arrest of DNA synthesis in plasmid-containing cells infected with unf-phage.	Chloramphenicol	16-31	Alc inhibitor of host transcription	Escherichia phage T4	149-152
6594136-6	1984	The reverse reaction, yielding acetyl-CoA and chloramphenicol, was studied in a coupled assay involving citrate synthase and malate dehydrogenase, and is best described by a rapid-equilibrium mechanism with random addition of substrates.	Chloramphenicol	46-61	citrate synthase	Homo sapiens	104-120
6594136-6	1984	The reverse reaction, yielding acetyl-CoA and chloramphenicol, was studied in a coupled assay involving citrate synthase and malate dehydrogenase, and is best described by a rapid-equilibrium mechanism with random addition of substrates.	Chloramphenicol	46-61	malic enzyme 1	Homo sapiens	125-145
6542061-6	1984	The combination of chloramphenicol orally and immunoglobulin intravenously resulted for the first time in complete freedom from bacteria in the CSF.	Chloramphenicol	19-34	colony stimulating factor 2	Homo sapiens	144-147
6491971-0	1984	Selective inhibition by chloramphenicol of cytochrome P-450 isozymes in rat lung and liver involved in the hydroxylation of n-hexane.	Chloramphenicol	24-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	43-59
6491971-12	1984	The results suggest that chloramphenicol acts as a selective suicide substrate of a constitutive isozyme of rat lung cytochrome P-450 involved in the 2-hydroxylation of n-hexane.	Chloramphenicol	25-40	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	117-133
6491977-7	1984	Prothrombin complex activity in plasma was not affected by in vitro addition or in vivo administration of chloramphenicol alone.	Chloramphenicol	106-121	coagulation factor II	Rattus norvegicus	0-11
6425267-3	1984	Transformation increased with time after addition of donor DNA up to 15 to 18 h. The peak of transformation efficiency (transformants/donor molecule) occurred at plasmid concentrations of 125 to 325 ng/ml with an ampicillin resistance donor plasmid (pCH1) and 300 to 625 ng/ml for chloramphenicol resistance conferred by plasmid pSG111.	Chloramphenicol	281-296	VRK serine/threonine kinase 1	Homo sapiens	250-254
6092418-3	1984	Chloramphenicol showed good activity against most tested strains of Salmonella spp., Shigella spp., and C. jejuni.	Chloramphenicol	0-15	histocompatibility minor 13	Homo sapiens	79-82
6092418-3	1984	Chloramphenicol showed good activity against most tested strains of Salmonella spp., Shigella spp., and C. jejuni.	Chloramphenicol	0-15	histocompatibility minor 13	Homo sapiens	94-97
6746480-0	1984	Practical screening procedure for chloramphenicol in milk at low parts per billion level.	Chloramphenicol	34-49	Weaning weight-maternal milk	Bos taurus	53-57
6746480-1	1984	A relatively simple screening procedure for the detection of chloramphenicol in cow"s milk is detailed.	Chloramphenicol	61-76	Weaning weight-maternal milk	Bos taurus	86-90
6746480-4	1984	Milk containing greater than or equal to 4 ppb chloramphenicol can be detected.	Chloramphenicol	47-62	Weaning weight-maternal milk	Bos taurus	0-4
6365403-5	1984	The NAG excretion rate was significantly higher in gentamicin-treated patients (138 +/- 10 U/min, mean +/- SE) than in amikacin-treated patients (85 +/- 7 U/min) but did not differ between patients treated with amikacin and those treated with chloramphenicol (81 +/- 11 U/min).	Chloramphenicol	243-258	O-GlcNAcase	Homo sapiens	4-7
6660855-3	1983	Subinhibitory concentrations of lincosamines, erythromycin, and chloramphenicol decreased fibronectin binding to Staphylococcus aureus, whereas beta-lactam antibiotics enhanced this interaction.	Chloramphenicol	64-79	fibronectin 1	Homo sapiens	90-101
6709665-0	1984	Studies on chloramphenicol-lysozyme interactions by fluorescence quenching.	Chloramphenicol	11-26	lysozyme	Homo sapiens	27-35
6354181-2	1983	Plasmid-encoded fusidic acid resistance in Escherichia coli is mediated by a common variant of chloramphenicol acetyltransferase (EC 2.3.1.28), an enzyme which is an effector of chloramphenicol resistance.	Chloramphenicol	95-110	acetyltransferase	Escherichia coli	111-128
6639272-0	1983	Reduced degradability by lysozyme of staphylococcal cell walls after chloramphenicol treatment.	Chloramphenicol	69-84	lysozyme	Homo sapiens	25-33
6416927-1	1983	A cloned Bacillus pumilus cat gene expresses chloramphenicol-inducible chloramphenicol acetyltransferase activity in Bacillus subtilis.	Chloramphenicol	45-60	AKO65_RS07595	Bacillus pumilus	87-104
6619096-7	1983	Transfer of chloramphenicol resistance by transformation with omega (cat tet) donor DNA, however, was blocked in Rec- mutants to about the same extent as was transformation for point markers.	Chloramphenicol	12-27	RBPJ pseudogene 4	Homo sapiens	113-116
6639272-3	1983	This study presents evidence that the additional wall material built in the presence of chloramphenicol could moreover be rendered more resistant to lysosomal enzymes: In vitro at pH 5.6, lysozyme from hen egg-white proved to degrade the chloramphenicol-wall material at a velocity reduced to 20% of that of the normal wall.	Chloramphenicol	88-103	lysozyme	Homo sapiens	188-196
6639272-3	1983	This study presents evidence that the additional wall material built in the presence of chloramphenicol could moreover be rendered more resistant to lysosomal enzymes: In vitro at pH 5.6, lysozyme from hen egg-white proved to degrade the chloramphenicol-wall material at a velocity reduced to 20% of that of the normal wall.	Chloramphenicol	238-253	lysozyme	Homo sapiens	188-196
6601233-5	1983	These data obtained with radiolabeled chloramphenicol suggest that the same metabolic pathways which lead to the inactivation of cytochrome P-450 in vitro are also operative in vivo.	Chloramphenicol	38-53	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	129-145
6956790-5	1982	All strains inactivated chloramphenicol by acetylation, with the production of chloramphenicol acetyltransferase.	Chloramphenicol	24-39	GNAT family N-acetyltransferase	Alcaligenes faecalis	95-112
6601233-0	1983	Suicide inactivation of rat liver cytochrome P-450 by chloramphenicol in vivo and in vitro.	Chloramphenicol	54-69	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	34-50
6601233-1	1983	Intraperitoneal administration of chloramphenicol (100 mg/kg) to phenobarbital-treated rats causes 50% inhibition of liver microsomal 7-ethoxycoumarin and 1,1,2,2 tetrachloroethane metabolism but has no effect on the level of cytochrome P-450 detectable as its carbon monoxide complex or on the NADPH-cytochrome c reductase (EC 1.6.2.4) activity.	Chloramphenicol	34-49	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	226-242
6601233-2	1983	Both the endogenous NADPH oxidase activity and the enzymatic reduction of cytochrome P-450 are inhibited by chloramphenicol treatment, whereas the Km and Ks for ethoxycoumarin and the cumene hydroperoxide- or iodosobenzene-supported deethylation of ethoxycoumarin are unaffected, suggesting that impaired electron transport to cytochrome P-450 may be the cause of the loss of enzymatic activity.	Chloramphenicol	108-123	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	74-90
6601233-2	1983	Both the endogenous NADPH oxidase activity and the enzymatic reduction of cytochrome P-450 are inhibited by chloramphenicol treatment, whereas the Km and Ks for ethoxycoumarin and the cumene hydroperoxide- or iodosobenzene-supported deethylation of ethoxycoumarin are unaffected, suggesting that impaired electron transport to cytochrome P-450 may be the cause of the loss of enzymatic activity.	Chloramphenicol	108-123	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	327-343
6813981-1	1982	Chloramphenicol-resistant (CAPr) reconstituted cells and cybrids were isolated by fusion of karyoplasts (or intact cells) of mouse amelanotic melanoma B16 cells with cytoplasts of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) -deficient, CAPr rat myoblastic cells, L6TG.CAPr, and double selection in HAT medium containing CAP.	Chloramphenicol	0-15	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	180-226
6342101-9	1983	The occurrence of beta-lactamase-mediated resistance to ampicillin in as high as 15% of isolates of H. influenzae has resulted in combined use of ampicillin and chloramphenicol for meningitis in children.	Chloramphenicol	161-176	beta-lactamase TEM-1	Haemophilus influenzae	18-32
6196945-3	1983	The effect of different inhibitors like actinomycin D, chloramphenicol, tetracycline, nitrofurantoin and rifampicin on histidase induction was also studied.	Chloramphenicol	55-70	histidine ammonia-lyase	Homo sapiens	119-128
6340955-1	1983	Naturally occurring chloramphenicol resistance in bacteria is normally due to the presence of the antibiotic inactivating enzyme chloramphenicol acetyltransferase (CAT) which catalyzes the acetyl-S-CoA-dependent acetylation of chloramphenicol at the 3-hydroxyl group.	Chloramphenicol	20-35	chloramphenicol acetyltransferase	Escherichia coli	129-162
6340955-1	1983	Naturally occurring chloramphenicol resistance in bacteria is normally due to the presence of the antibiotic inactivating enzyme chloramphenicol acetyltransferase (CAT) which catalyzes the acetyl-S-CoA-dependent acetylation of chloramphenicol at the 3-hydroxyl group.	Chloramphenicol	20-35	chloramphenicol acetyltransferase	Escherichia coli	164-167
6340955-1	1983	Naturally occurring chloramphenicol resistance in bacteria is normally due to the presence of the antibiotic inactivating enzyme chloramphenicol acetyltransferase (CAT) which catalyzes the acetyl-S-CoA-dependent acetylation of chloramphenicol at the 3-hydroxyl group.	Chloramphenicol	129-144	chloramphenicol acetyltransferase	Escherichia coli	164-167
6340955-3	1983	The synthesis of CAT is constitutive in E. coli and other Gram-negative bacteria which harbor plasmids bearing the structural gene for the enzyme, whereas Gram-positive bacteria such as staphylococci and streptococci synthesize CAT only in the presence of chloramphenicol and related compounds, especially those with the same stereochemistry of the parent compound and which lack antibiotic activity and a site of acetylation (3-deoxychloramphenicol).	Chloramphenicol	256-271	chloramphenicol acetyltransferase	Escherichia coli	17-20
6950931-2	1982	The genetic determinant of chloramphenicol (CAM) resistance, which includes the chloramphenicol acetyl transferase (CAT) structural gene, the putative promoter and controlling element of this determinant, have been mapped functionally by subcloning a 1,035-nucleotide fragment which specifies the resistance phenotype using plasmid pBR322 as vector.	Chloramphenicol	27-42	chloramphenicol acetyltransferase	Escherichia coli	116-119
6950931-2	1982	The genetic determinant of chloramphenicol (CAM) resistance, which includes the chloramphenicol acetyl transferase (CAT) structural gene, the putative promoter and controlling element of this determinant, have been mapped functionally by subcloning a 1,035-nucleotide fragment which specifies the resistance phenotype using plasmid pBR322 as vector.	Chloramphenicol	44-47	chloramphenicol acetyltransferase	Escherichia coli	116-119
7045654-4	1982	A repair pathway is postulated which is pre-replicative, unaffected by chloramphenicol, acriflavine or caffeine, and inhibited at 0 degrees C. It is unaffected by a rep mutation but is blocked by a polA mutation, suggesting that it involves DNA strand breakage and at least some exonuclease action.	Chloramphenicol	71-86	replication protein	Escherichia coli	2-5
6811722-5	1982	The UDPGT activities towards p-nitrophenol, 1-naphthol and chloramphenicol were increased up to 6,2.5 and 1.8 folds of control levels respectively, in microsomes from m-TAN treated rats.	Chloramphenicol	59-74	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	4-9
7059351-5	1982	Chloramphenicol and thiamphenicol decreased significantly the activities of kynurenine hydrolase, beta-glucuronidase and acid ribonuclease and both drugs increased the activity of pyridoxal phosphokinase significantly.	Chloramphenicol	0-15	glucuronidase, beta	Mus musculus	98-116
7065646-2	1982	It was shown that sensitivity of NAG-vibrio to chloramphenicol, ampicillin, cephaloridine and streptomycin decreased.	Chloramphenicol	47-62	NBAS subunit of NRZ tethering complex	Homo sapiens	33-36
7065646-3	1982	However, NAG-vibrio remain to be sensitive to tetracycline, chloramphenicol and gentamicin.	Chloramphenicol	60-75	NBAS subunit of NRZ tethering complex	Homo sapiens	9-12
6278418-1	1982	We have investigated the processing of transcripts of the split gene COB in yeast mitochondrial DNA from cells whose mitochondrial translation was blocked by chloramphenicol for several generations of cell growth.	Chloramphenicol	158-173	cytochrome b	Saccharomyces cerevisiae S288C	69-72
7149923-1	1982	The effect of cycloheximide, chloramphenicol, ethidium bromide (EB), aurin tricarboxylic acid (ATA), and actinomycin D on the production of interferon (IFN) in human embryo fibroblasts (HAT) and L929 cells, stimulated with RNA from Piptoporus betulinus (Pb-RNA) was studied.	Chloramphenicol	29-44	interferon alpha 1	Homo sapiens	140-156
6271642-2	1981	Chloramphenicol-resistant revertants retaining a lactose operator in the CAT gene of plasmid pBR325.	Chloramphenicol	0-15	catalase	Homo sapiens	73-76
6981494-2	1982	The MICs of chloramphenicol against these three beta-lactamase-producing H. influenzae isolates were 8, 3.1 and 16 micrograms/ml, and those of cefuroxime were 0.25, 0.5 and 0.12 microgram/ml, respectively.	Chloramphenicol	12-27	beta-lactamase TEM-1	Haemophilus influenzae	48-62
7128475-3	1982	Chloramphenicol also decreased microsomal lipid peroxidation in both CCl4 and methanol-pretreated, CCl4-intoxicated animals when measured 30 minutes after exposure.	Chloramphenicol	0-15	C-C motif chemokine ligand 4	Rattus norvegicus	69-73
7128475-3	1982	Chloramphenicol also decreased microsomal lipid peroxidation in both CCl4 and methanol-pretreated, CCl4-intoxicated animals when measured 30 minutes after exposure.	Chloramphenicol	0-15	C-C motif chemokine ligand 4	Rattus norvegicus	99-103
7128475-4	1982	Chloramphenicol prevented the loss of glucose 6-phosphatase activity after CCl4 and methanol.	Chloramphenicol	0-15	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	38-59
7128475-4	1982	Chloramphenicol prevented the loss of glucose 6-phosphatase activity after CCl4 and methanol.	Chloramphenicol	0-15	C-C motif chemokine ligand 4	Rattus norvegicus	75-79
7132955-0	1982	Further studies of the suicide inactivation of purified rat liver cytochrome P-450 by chloramphenicol.	Chloramphenicol	86-101	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-82
7132955-1	1982	The kinetics and reversibility of the suicide inactivation of rat liver cytochrome P-450 by chloramphenicol have been investigated with the use of a reconstituted monooxygenase system purified from liver microsomes of phenobarbital-treated rats.	Chloramphenicol	92-107	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	72-88
7132955-8	1982	Trapping experiments with the amino acid cysteine suggest that the adduct, the spontaneous degradation of which appears to be involved in the reactivation of cytochrome P-450, contains an ester rather than a thioester linkage between cytochrome P-450 and a metabolite of chloramphenicol.	Chloramphenicol	271-286	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	158-174
7128475-0	1982	Modification of methanol potentiation of CCl4 toxicity in rats by chloramphenicol and salicylate.	Chloramphenicol	66-81	C-C motif chemokine ligand 4	Rattus norvegicus	41-45
7128475-2	1982	Chloramphenicol, an inhibitor of cytochrome P-450, blocked the increase of serum glutamate-oxaloacetate transaminase activity enhanced by methanol pretreatment of rats exposed to CCl4.	Chloramphenicol	0-15	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	33-49
7128475-2	1982	Chloramphenicol, an inhibitor of cytochrome P-450, blocked the increase of serum glutamate-oxaloacetate transaminase activity enhanced by methanol pretreatment of rats exposed to CCl4.	Chloramphenicol	0-15	C-C motif chemokine ligand 4	Rattus norvegicus	179-183
7054485-0	1982	Seminar on antibiotics VIII chloramphenicol.	Chloramphenicol	28-43	cytochrome c oxidase subunit 8A	Homo sapiens	23-27
7339071-2	1981	Binding of several antibiotics, including cefotetan, benzylpenicillin, cefazolin, chloramphenicol and gentamicin, to cationic and anionic GSH S-transferases isolated from human liver, and to human serum albumin, has been investigated by using the centrifuge column technique, which is supposed to be an excellent one for its sensitivity and rapidity in ligand binding studies.	Chloramphenicol	82-97	glutathione synthetase	Homo sapiens	138-143
6974540-1	1981	We compared a rigid (1-h) screening method for the detection of chloramphenicol acetyltransferase (CAT) activity with the standard spectrophotometric CAT assay to determine whether CAT-mediated chloramphenicol resistance in Haemophilus influenzae could be determined upon primary isolation.	Chloramphenicol	64-79	chloramphenicol acetyltransferase II	Haemophilus influenzae	99-102
6974540-2	1981	Of 58 H. influenzae cell sonicates, 28 had detectable CAT activity when the chloramphenicol-dependent production of free coenzyme A from acetyl coenzyme A was measured spectrophotometrically (standard method).	Chloramphenicol	76-91	chloramphenicol acetyltransferase II	Haemophilus influenzae	54-57
6974540-5	1981	This 1-h test for CAT should prove to be useful for the early presumptive identification of chloramphenicol resistance in H. influenzae.	Chloramphenicol	92-107	chloramphenicol acetyltransferase II	Haemophilus influenzae	18-21
6974541-7	1981	The rates at which beta-lactamase-producing strains were killed by chloramphenicol, cefotaxime, and moxalactam was not influenced by the inoculum size.	Chloramphenicol	67-82	beta-lactamase TEM-1	Haemophilus influenzae	19-33
7286060-3	1981	The t 1/2 of chloramphenicol showed a significant correlation with serum albumin and prothrombin time index.	Chloramphenicol	13-28	coagulation factor II, thrombin	Homo sapiens	85-96
6283818-0	1981	Effects of methanol and chloramphenicol on CCl4 toxicity.	Chloramphenicol	24-39	C-C motif chemokine ligand 4	Homo sapiens	43-47
7038031-1	1981	Chloramphenicol resistance-specifying plasmids from incompatibility groups P-1 and C did not encode chloramphenicol acetyltransferase (CAT).	Chloramphenicol	0-15	crystallin gamma F, pseudogene	Homo sapiens	75-84
7238316-1	1981	Serum and CSF levels of chloramphenicol were determined repeatedly during the course of treatment in 24 premature and full term babies and infants with bacterial meningitis.	Chloramphenicol	24-39	colony stimulating factor 2	Homo sapiens	10-13
7243382-6	1981	At 6 degrees C, net influx for both antibiotics was less than the influx observed at 37 degrees C. Net influx again increased with increasing antibiotic concentrations in the bath but at a slower rate (0.29 ng/min.trachea per microgram/ml for chloramphenicol and 0.25 ng/min.trachea per microgram/ml for tetracycline).	Chloramphenicol	243-258	solute carrier family 6 member 2	Rattus norvegicus	99-102
7040015-0	1981	Inactivation of rat liver cytochrome P-450 by the suicide substrates parathion and chloramphenicol.	Chloramphenicol	83-98	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	26-42
29219-3	1978	Multiply resistant Type 19A strains, resistant to beta-lactam antibiotics, erythromycin, clindamycin, tetracycline and chloramphenicol, were isolated from 128 carriers, and were responsible for bacteremia in four patients.	Chloramphenicol	119-134	SLAM family member 7	Homo sapiens	24-27
7208582-1	1980	Part 5: Influence of the volume of disperse phase on liberation of chloramphenicol from emulsifying ointments (author"s transl)].	Chloramphenicol	67-82	tankyrase	Homo sapiens	0-6
7405936-1	1980	The effect of hemodialysis on the total body clearance (ClTB) of chloramphenicol was studied in two patients with renal failure and hepatic dysfunction.	Chloramphenicol	65-80	clathrin light chain B	Homo sapiens	56-60
6987361-5	1980	In seven patients who had concomitant serum and CSF chloramphenicol levels determined, a CSF to serum ratio of 23 to 85% occurred.	Chloramphenicol	52-67	colony stimulating factor 2	Homo sapiens	48-51
6987361-5	1980	In seven patients who had concomitant serum and CSF chloramphenicol levels determined, a CSF to serum ratio of 23 to 85% occurred.	Chloramphenicol	52-67	colony stimulating factor 2	Homo sapiens	89-92
6987664-4	1980	Yeast cells harboring pYT11-LEU2 acquire resistance to chloramphenicol and cell-free extracts prepared from such cells contain chloramphenicol acetyltransferase (acetyl-CoA: chloramphenicol 3-O-acetyltransferase, EC 2.3.1.28), the enzyme specified by the camr gene in E. coli.	Chloramphenicol	55-70	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	28-32
6987664-5	1980	Resistance to chloramphenicol and the presence of chloramphenicol acetyltransferase activity segregate with the yeast marker LEU2, carried by the transforming plasmid, during both mitotic growth and meiotic division.	Chloramphenicol	14-29	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	125-129
6257590-1	1980	The specificity of integration of chloramphenicol resistance transposon (Tn9) into Vibrio El Tor chromosome was studied.	Chloramphenicol	34-49	RAR related orphan receptor C	Homo sapiens	93-96
6254035-5	1980	Two of these ACTH-responsive proteins are among the nine major adrenal polypeptides that fulfill the criteria of mitochondrial translation products: (i) their synthesis in intact cells is specifically resistant to inhibition by cycloheximide yet uniquely sensitive to chloramphenicol and (ii) they are synthesized in vitro by isolated mitochondria.	Chloramphenicol	268-283	pro-opiomelanocortin-alpha	Mus musculus	13-17
7265601-7	1980	These results suggest that chloramphenicol and clindamycin may inhibit Ca2+ influx through the Ca2+ channels across the smooth muscle cell membrane.	Chloramphenicol	27-42	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	71-74
7265601-7	1980	These results suggest that chloramphenicol and clindamycin may inhibit Ca2+ influx through the Ca2+ channels across the smooth muscle cell membrane.	Chloramphenicol	27-42	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	95-98
119159-7	1979	Actinomycin D appeared to inhibit the release of newly synthesized albumin into the bloodstream while chloramphenicol treatment appeared to inhibit the incorporation of cytochrome c into the mitochondria.	Chloramphenicol	102-117	cytochrome c	Oryctolagus cuniculus	169-181
464559-0	1979	[Pathways of enzymatic inactivation of levomycetin in El Tor vibrios with plasmid and chromosome resistance to the antibiotic].	Chloramphenicol	39-50	RAR related orphan receptor C	Homo sapiens	57-60
352690-7	1978	The incorporation of radioactive leucine into the apoprotein of cytochrome b isolated by immunoprecipitation followed by gel electrophoresis was insensitive to cycloheximide (an inhibitor of cytoplasmic protein synthesis) and sensitive to acriflavin, erythromycin, and chloramphenicol (inhibitors of mitochondrial protein synthesis).	Chloramphenicol	269-284	cytochrome b	Saccharomyces cerevisiae S288C	64-76
703761-1	1978	The transfer of a Chl element, causing resistance to chloramphenicol in Streptomyces coelicolor A3(2), was studied in NF x SCP1- superfertile crosses.	Chloramphenicol	53-68	chordin like 1	Homo sapiens	18-21
363177-2	1978	Plasmid DNAs of Col E1, RSF 2124 amplificated for 4 hours in the presence of chloramphenicol are sensitive to R. Eco RII but after 16-hour amplification in the presence of chloramphenicol these DNAs acquire complete resistance against R. Eco RII.	Chloramphenicol	77-92	EcoRII restriction enzyme	Escherichia coli	113-120
363177-2	1978	Plasmid DNAs of Col E1, RSF 2124 amplificated for 4 hours in the presence of chloramphenicol are sensitive to R. Eco RII but after 16-hour amplification in the presence of chloramphenicol these DNAs acquire complete resistance against R. Eco RII.	Chloramphenicol	77-92	EcoRII restriction enzyme	Escherichia coli	238-245
1270405-6	1976	The effects of actinomycin D, 6-methylpurine, cycloheximide, chloramphenicol, and mitomycin C on the induction of phenylalanine ammonia-lyase were investigated during incubation of the disks.	Chloramphenicol	61-76	phenylalanine ammonia-lyase	Solanum tuberosum	114-141
340224-3	1977	Based on the constancy of Kb over the range of inhibitor concentration, it was determined that the binding site of the 2" isomers IIa-IIc overlaps with the chloramphenicol site, whereas the variability of Kb for the 3" isomers IIIb, IIIc and especially IIIa seems to indicate that they do not achieve a complete fit.	Chloramphenicol	156-171	colicin Ia immunity protein	Escherichia coli	130-133
605152-0	1977	The in vivo effect of chloramphenicol on acetylcholinesterase and cholinergic synaptic membrane of chick embryo brain.	Chloramphenicol	22-37	acetylcholinesterase (Cartwright blood group)	Gallus gallus	41-61
10448-10	1976	Chloramphenicol partially inhibited the increase of GTase induced by 2-acetylaminofluorene.	Chloramphenicol	0-15	gamma-glutamyltransferase 1	Rattus norvegicus	52-57
1023818-2	1976	Observation of a group of patients with acute gastro-intestinal infections caused by NAG-vibrio and carriers of NAG-vibrioes showed that the rate of vibrio isolation after a course of antibiotic therapy (tetracycline, levomycetin) significantly decreased as compared to that in the group of the patients subjected only to symptomatic therapy.	Chloramphenicol	218-229	NBAS subunit of NRZ tethering complex	Homo sapiens	112-115
16659534-1	1976	Photocontrol of the Source Of Reducing Power for Chloramphenicol Reduction by the Ferredoxin-NADP Reductase System.	Chloramphenicol	49-64	ferredoxin reductase	Homo sapiens	82-107
16659534-11	1976	We infer that chloramphenicol is reduced by ferredoxin which receives electrons via ferredoxin-NADP reductase.	Chloramphenicol	14-29	ferredoxin reductase	Homo sapiens	84-109
349350-1	1978	Degradation of messenger RNA from the lactose operon (lac mRNA) was measured during the inhibition of protein synthesis by chloramphenicol (CM) or of translation-initiation by kasugamycin (KAS).	Chloramphenicol	123-138	lactase	Homo sapiens	38-41
146819-4	1978	The expression of chloramphenicol (Cm) and fusidic acid (Fus) resistance requires EcoRI fragments A and J of NR1.	Chloramphenicol	18-33	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	109-112
146819-4	1978	The expression of chloramphenicol (Cm) and fusidic acid (Fus) resistance requires EcoRI fragments A and J of NR1.	Chloramphenicol	35-37	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	109-112
897766-0	1977	[Dynamic changes of lysozyme concentration in the blood serum in patients with typhoid fever treated levomycetin in conjunction with prednisolone and butadione].	Chloramphenicol	101-112	lysozyme	Homo sapiens	20-28
322700-0	1977	Treatment of TRIC infection of the eye with rifampicin or chloramphenicol.	Chloramphenicol	58-73	MARVEL domain containing 2	Homo sapiens	13-17
332592-2	1977	Chloramphenicol induces the synthesis of colicins B1, B4, K, V3 and, possibly, Ib-P9.	Chloramphenicol	0-15	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	50-63
332592-2	1977	Chloramphenicol induces the synthesis of colicins B1, B4, K, V3 and, possibly, Ib-P9.	Chloramphenicol	0-15	cellular communication network factor 3	Homo sapiens	79-84
932938-1	1976	Experiments with the guinea pig ileum, guinea pig trachea, rat fundal strip, rat colon, rat vas deferens, and toad heart indicated that chloramphenicol inhibited smooth muscles, decreasing both the height and frequency of spontaneous contraction.	Chloramphenicol	136-151	arginine vasopressin	Rattus norvegicus	92-95
767321-6	1976	In addition  the levels of plasmid DNA transcription and chloramphenicol acetyltransferase activity in the high-level resistant strain were found to be further increased by the presence of high levels of chloramphenicol in the growth medium.	Chloramphenicol	57-72	acetyltransferase	Escherichia coli	73-90
800292-3	1975	CAP-23 cells in the presence of 40 or 100 microng/ml chloramphenicol grew at essentially the same rate as cells in the absence of the drug; chloramphenicol resistance persisted even after 20 generations in the absence of the drug.	Chloramphenicol	53-68	brain abundant membrane attached signal protein 1	Homo sapiens	0-6
172130-0	1975	ATPase complex and oxidative phosphorylation in chloramphenicol-induced megamitochondria from mouse liver.	Chloramphenicol	48-63	dynein, axonemal, heavy chain 8	Mus musculus	0-6
1200558-1	1975	In the present experimental study the role of lysozyme drops in healing of corneal ulcer of staphylococcal origin (sensitive to chloramphenicol) was studied on 16 albino rabbits.	Chloramphenicol	128-143	lysozyme C-like	Oryctolagus cuniculus	46-54
800292-6	1975	In vitro protein synthesis in mitochondria isolated from CAP-23 cells showed, likewise, low levels of inhibition by chloramphenicol.	Chloramphenicol	116-131	brain abundant membrane attached signal protein 1	Homo sapiens	57-63
16659023-5	1975	The inhibition of phosphoglycolate phosphatase synthesis by d-threo-chloramphenicol but not by l-threo-chloramphenicol or cycloheximide shows that the enzyme was synthesized exclusively on chloroplast ribosomes, whereas protein synthesis on both chloroplast and cytoplasmic ribosomes was required for the formation of ribulose 1,5-diphosphate carboxylase.	Chloramphenicol	60-83	phosphoglycolate phosphatase	Homo sapiens	18-46
165191-6	1975	Chloramphenicol exhibits a somewhat intermediate effect on cytochrome b synthesis, with transient inhibition occurring only when the drug is added prior to or during the initial part of the first cell cycle.	Chloramphenicol	0-15	cytochrome b	Saccharomyces cerevisiae S288C	59-71
234394-0	1975	A negative cooperative binding process between chloramphenicol and sodium dodecyl sulphate to bovine serum albumin: a possible effect on drug absorption.	Chloramphenicol	47-62	albumin	Homo sapiens	101-114
4584805-0	1973	Conjugal deoxyribonucleic acid replication by Excherichia coli K-12: effect of chloramphenicol and rifampin.	Chloramphenicol	79-94	keratin 12	Homo sapiens	63-67
4550967-0	1972	Chloramphenicol rescue of  -irradiated lon and exrA mutants of Escherichia coli.	Chloramphenicol	0-15	putative ATP-dependent Lon protease	Escherichia coli	39-42
24458789-0	1973	Induction of nitrate reductase by chloramphenicol in detached cucumber cotyledons.	Chloramphenicol	34-49	nitrate reductase [NADH]-like	Cucumis sativus	13-30
24458789-1	1973	Chloramphenicol (CAP) induced nitrate reductase activity (NRA) in detached, etiolated cucumber (Cucumis sativus L.) cotyledons.	Chloramphenicol	0-15	nitrate reductase [NADH]-like	Cucumis sativus	30-47
24458789-1	1973	Chloramphenicol (CAP) induced nitrate reductase activity (NRA) in detached, etiolated cucumber (Cucumis sativus L.) cotyledons.	Chloramphenicol	17-20	nitrate reductase [NADH]-like	Cucumis sativus	30-47
4333316-6	1971	Chloramphenicol appears to affect a component of the respiratory chain between the flavoprotein and cytochrome c.	Chloramphenicol	0-15	cytochrome c, somatic	Homo sapiens	100-112
4583232-0	1973	Deletion map of the chloramphenicol resistance region of R1 and R100-1.	Chloramphenicol	20-35	ribonucleotide reductase catalytic subunit M1	Homo sapiens	57-70
4583232-1	1973	Recombination between single-site and multisite chloramphenicol-sensitive mutants of the F-like R factors R1 and R100-1 indicates that the chloramphenicol resistance region is a single structural gene coding for the 20,000-molecular weight subunit of chloramphenicol acetyltransferase.	Chloramphenicol	48-63	ribonucleotide reductase catalytic subunit M1	Homo sapiens	106-119
4583232-1	1973	Recombination between single-site and multisite chloramphenicol-sensitive mutants of the F-like R factors R1 and R100-1 indicates that the chloramphenicol resistance region is a single structural gene coding for the 20,000-molecular weight subunit of chloramphenicol acetyltransferase.	Chloramphenicol	139-154	ribonucleotide reductase catalytic subunit M1	Homo sapiens	106-119
4562410-4	1972	Multiple antibiotic resistance (chloramphenicol, streptomycin, tetracycline; ChlR-StrR-TetR) carried on R factor SR1 was transferred from a clinical isolate of S. flexneri 1a to strains of E. aroideae, E. chrysanthemi, E. herbicola, and E. nigrifluens, but not to strains of other Erwinia spp.	Chloramphenicol	32-47	tetracycline resistance repressor protein TetR	Escherichia coli	87-91
4335248-1	1972	Exposure of HeLa and L cells to chloramphenicol causes a progressive dose-dependent decrease in cytochrome oxidase and succinate-cytochrome c reductase activities, concomitant with an increase in the amount of cytochrome c.	Chloramphenicol	32-47	cytochrome c, somatic	Homo sapiens	129-141
4335248-1	1972	Exposure of HeLa and L cells to chloramphenicol causes a progressive dose-dependent decrease in cytochrome oxidase and succinate-cytochrome c reductase activities, concomitant with an increase in the amount of cytochrome c.	Chloramphenicol	32-47	cytochrome c, somatic	Homo sapiens	210-222
4945186-3	1971	Delayed beta-galactosidase formation was found in relaxed auxotrophs recovering from amino acid starvation and in prototrophs recovering from chloramphenicol or from tetracycline treatment.	Chloramphenicol	142-157	galactosidase beta 1	Homo sapiens	8-26
5540765-0	1971	The survival of glucose-6-phosphate dehydrogenase--deficient erythrocytes in patients with typhoid fever on chloramphenicol therapy.	Chloramphenicol	108-123	glucose-6-phosphate dehydrogenase	Homo sapiens	16-49
5403284-0	1969	[Suppression by lysine-vasopressin of the inhibitory effect of chloramphenicol on the growth of KB cell cultures].	Chloramphenicol	63-78	arginine vasopressin	Homo sapiens	23-34
5477228-0	1970	The effect of chloramphenicol treatment on ferrochelatase activity in dogs.	Chloramphenicol	14-29	ferrochelatase	Canis lupus familiaris	43-57
4312913-0	1970	Selective inhibition by chloramphenicol of ACTH-induced reorganization of inner mitochondrial membranes in fetal adrenal cortical cells in tissue cultures.	Chloramphenicol	24-39	proopiomelanocortin	Homo sapiens	43-47
4907118-0	1968	[Antibacterial effect of chloramphenicol and nitrofurantoin under the effect of lysozyme].	Chloramphenicol	25-40	lysozyme	Homo sapiens	80-89
4977987-3	1969	The compound related to d-threo chloramphenicol which lacks a C(3) hydroxyl substituent (3-deoxychloramphenicol) is a potent inducer of chloramphenicol acetyltransferase but is ineffective as an antibiotic and is not a substrate for the enzyme.	Chloramphenicol	24-47	CAT	Staphylococcus aureus	136-169
5781585-4	1969	The appearance of enterotoxin was inhibited by chloramphenicol; thus, the presence of toxin was dependent on de novo protein synthesis.	Chloramphenicol	47-62	Enterotoxin	Staphylococcus aureus	18-29
5781585-4	1969	The appearance of enterotoxin was inhibited by chloramphenicol; thus, the presence of toxin was dependent on de novo protein synthesis.	Chloramphenicol	47-62	AT695_RS01930	Staphylococcus aureus	24-29
5365571-0	1969	[Spontaneous and chloramphenicol-induced chromosome mutations and biochemical data in 2 cases with glutathione reductase deficiency (NAD(P)H: glutathione oxidoreductase, E.C.1.6.4.2.	Chloramphenicol	17-32	thioredoxin reductase 1	Homo sapiens	154-168
4876128-2	1968	In the presence of chloramphenicol, these bacteria grew at 34 C but not at 43 C. The mutations in the chloramphenicol resistance gene of the R factors affected neither the resistance of the bacteria to dihydrostreptomycin and tetracycline nor the stability of the R factors at 43 C. The chloramphenicol acetyltransferase obtained from Escherichia coli K-12 carrying the mutant R factors was heat-labile as compared with that from a strain carrying the wild-type R factor.	Chloramphenicol	19-34	acetyltransferase	Escherichia coli	303-320
4876128-2	1968	In the presence of chloramphenicol, these bacteria grew at 34 C but not at 43 C. The mutations in the chloramphenicol resistance gene of the R factors affected neither the resistance of the bacteria to dihydrostreptomycin and tetracycline nor the stability of the R factors at 43 C. The chloramphenicol acetyltransferase obtained from Escherichia coli K-12 carrying the mutant R factors was heat-labile as compared with that from a strain carrying the wild-type R factor.	Chloramphenicol	102-117	acetyltransferase	Escherichia coli	303-320
4876128-4	1968	The results strongly suggest that the chloramphenicol resistance gene of the R factors is the structural gene of the chloramphenicol acetyltransferase rather than the genome controlling the expression of a chromosomal determinant for the enzyme.	Chloramphenicol	38-53	acetyltransferase	Escherichia coli	133-150
4876128-5	1968	Furthermore, the studies confirm that the existence of the chloramphenicol acetyltransferase is the primary cause of chloramphenicol resistance of bacteria carrying the R factor.	Chloramphenicol	59-74	acetyltransferase	Escherichia coli	75-92
6074217-0	1967	[Changes in activity in alanine aminotransferase and aspartate aminotransferase in rat serum after administration of chloramphenicol].	Chloramphenicol	117-132	glutamic--pyruvic transaminase	Homo sapiens	24-48
4298603-0	1968	[Effect of some antibiotics on the transfer of the resistance to tetracycline and chloramphenicol by means of the episome factor (Rtf)].	Chloramphenicol	82-97	ATPase H+ transporting V0 subunit a2	Homo sapiens	130-133
5735408-0	1968	Chloramphenicol resistance of Staphylococcus aureus: inducers of chloramphenicol acetyltransferase.	Chloramphenicol	0-15	CAT	Staphylococcus aureus	65-98
24554107-9	1966	The formation of ribulose diphosphate carboxylase and transketolase is strongly suppressed by low temperature or chloramphenicol.	Chloramphenicol	113-128	transketolase	Homo sapiens	54-67
5322786-0	1965	[Clinical experiments with a combination of antibiotics: tetracycline-chloramphenicol-lysozyme].	Chloramphenicol	70-85	lysozyme	Homo sapiens	86-94
24554107-17	1966	When the formation of ribulose diphosphate carboxylase is prevented by low temperature or chloramphenicol, the increase of glucose-6-phosphate dehydrogenase continues at a constant rate.	Chloramphenicol	90-105	glucose-6-phosphate dehydrogenase	Homo sapiens	123-156
14297373-0	1965	THE EFFECT OF CHLORAMPHENICOL ON CYTOCHROME C AND CYTOCHROME OXIDASE PREPARATION IN VITRO.	Chloramphenicol	14-29	cytochrome c, somatic	Homo sapiens	33-45
5881059-0	1965	[Effect of levomycetin on blood proteins and prothrombin].	Chloramphenicol	11-22	coagulation factor II, thrombin	Homo sapiens	45-56
14099617-0	1963	THE STIMULATION BY CHLORAMPHENICOL OF "REPRESSOR" FORMATION IN ESCHERICHIA COLI.	Chloramphenicol	19-34	repressor	Escherichia coli	39-48
15424372-0	1950	[202 cases of typhoid fever; comparative study of the antibiotic activity of racemic and levorotatory chloramphenicol in p39 patients].	Chloramphenicol	102-117	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	121-124
13634834-0	1959	[C-reactive protein in typhoid treated with combined chloramphenicol &amp; phenylbutazone].	Chloramphenicol	53-68	C-reactive protein	Homo sapiens	1-19
24544342-0	1957	[Formation of methemoglobin in the organism system of the patients and experimental animals under the influence of levomycetin].	Chloramphenicol	115-126	hemoglobin subunit gamma 2	Homo sapiens	14-27
33719123-7	2021	The ESBL-positives showed significantly higher resistance rates to gentamicin, co-trimoxazole, tetracycline, aztreonam, and chloramphenicol (P<0.05).	Chloramphenicol	124-139	EsbL	Escherichia coli	4-8
32474955-0	2020	Highly efficient chloramphenicol degradation by UV and UV/H2 O2 processes based on LED light source.	Chloramphenicol	17-32	small integral membrane protein 10 like 2A	Homo sapiens	83-86
32474955-1	2020	In this study, UV-LED was employed as a novel light source to investigate the degradation of a representative antibiotic compound, chloramphenicol (CAP), in the absence or presence of H2 O2 .	Chloramphenicol	131-146	small integral membrane protein 10 like 2A	Homo sapiens	18-21
32474955-1	2020	In this study, UV-LED was employed as a novel light source to investigate the degradation of a representative antibiotic compound, chloramphenicol (CAP), in the absence or presence of H2 O2 .	Chloramphenicol	148-151	small integral membrane protein 10 like 2A	Homo sapiens	18-21
32278109-3	2020	We aimed to characterise eight chloramphenicol resistant meningococcal isolates collected between 2007 and 2018 from diagnostic microbiology laboratories in Cambodia, Thailand and the Lao People"s Democratic Republic (Laos).	Chloramphenicol	31-46	interleukin 4 induced 1	Homo sapiens	184-187
33201916-9	2020	We constructed a chloramphenicol acetyltransferase (CAT) reporter gene containing this promoter sequence (rTRH(547)-CAT) and showed that GATA2 activated the promoter in monkey kidney-derived CV1 cells.	Chloramphenicol	17-32	GATA binding protein 2	Rattus norvegicus	137-142
31944172-11	2020	This study shows that sustained high autophagic flux by RUBCN deficiency in PTECs leads to metabolic syndrome concomitantly with an accelerated mobilization of phospholipids from cellular membranes to lysosomes.Abbreviations: ABC: ATP binding cassette; ACADM: acyl-CoA dehydrogenase medium chain; ACTB: actin, beta; ATG: autophagy related; AUC: area under the curve; Baf: bafilomycin A1; BAT: brown adipose tissue; BODIPY: boron-dipyrromethene; BSA: bovine serum albumin; BW: body weight; CAT: chloramphenicol acetyltransferase; CM: complete medium; CPT1A: carnitine palmitoyltransferase 1a, liver; CQ: chloroquine; CTRL: control; EGFP: enhanced green fluorescent protein; CTSD: cathepsin D; EAT: epididymal adipose tissue; EGFR: epidermal growth factor receptor; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1; FA: fatty acid; FBS: fetal bovine serum; GTT: glucose tolerance test; HE: hematoxylin and eosin; HFD: high-fat diet; I/R: ischemia-reperfusion; ITT: insulin tolerance test; KAP: kidney androgen regulated protein; KO: knockout; LAMP1: lysosomal associated membrane protein 1; LD: lipid droplet; LRP2: low density lipoprotein receptor related protein 2; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MAT: mesenteric adipose tissue; MS: mass spectrometry; MTOR: mechanistic target of rapamycin kinase; MTORC1: MTOR complex 1; NDRG1: N-myc downstream regulated 1; NDUFB5: NADH:ubiquinone oxidoreductase subunit B5; NEFA: non-esterified fatty acid; OA: oleic acid; OCT: optimal cutting temperature; ORO: Oil Red O; PAS: Periodic-acid Schiff; PFA: paraformaldehyde; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PPARA: peroxisome proliferator activated receptor alpha; PPARGC1A: PPARG coactivator 1 alpha; PTEC: proximal tubular epithelial cell; RAB7A: RAB7A, member RAS oncogene family; RPS6: ribosomal protein S6; RPS6KB1: ribosomal protein S6 kinase B1; RT: reverse transcription; RUBCN: rubicon autophagy regulator; SAT: subcutaneous adipose tissue; SFC: supercritical fluid chromatography; SQSTM1: sequestosome 1; SREBF1: sterol regulatory element binding transcription factor 1; SV-40: simian virus-40; TFEB: transcription factor EB; TG: triglyceride; TS: tissue specific; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; UN: urea nitrogen; UQCRB: ubiquinol-cytochrome c reductase binding protein; UVRAG: UV radiation resistance associated; VPS: vacuolar protein sorting; WAT: white adipose tissue.	Chloramphenicol	494-509	RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein	Mus musculus	56-61
31857248-5	2020	TP1 exhibited resistance to aminoglycosides (gentamicin and amikacin), macrolides (erythromycin), lincosamides (clindamycin), sulfonamides (sulfamonomethoxine), tetracyclines (tetracycline and doxycycline) and chloramphenicols (chloramphenicol and florfenicol).	Chloramphenicol	210-226	transition protein 1	Bos taurus	0-3
31857248-5	2020	TP1 exhibited resistance to aminoglycosides (gentamicin and amikacin), macrolides (erythromycin), lincosamides (clindamycin), sulfonamides (sulfamonomethoxine), tetracyclines (tetracycline and doxycycline) and chloramphenicols (chloramphenicol and florfenicol).	Chloramphenicol	210-225	transition protein 1	Bos taurus	0-3
32878289-2	2020	Escherichia coli DH5alpha were transformed with pPRO-EX-HT-CAT, which encodes an ampicillin resistance gene and chloramphenicol acetyltransferase (CAT) gene, and then treated with a dielectric barrier discharge (DBD) plasma torch.	Chloramphenicol	112-127	chloramphenicol acetyltransferase	Escherichia coli	59-62
32574791-0	2020	Transcriptomic responses of a New Delhi metallo-beta-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol.	Chloramphenicol	141-156	NDM-1	Klebsiella pneumoniae	30-62
32574791-1	2020	The combination of polymyxin and chloramphenicol possesses synergistic killing against New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae.	Chloramphenicol	33-48	NDM-1	Klebsiella pneumoniae	87-119
33165592-5	2020	Herein, chloramphenicol, which inhibits mitochondrial DNA-encoded protein expression, induced eIF2a phosphorylation and ATF4 induction, leading to ISR gene expression.	Chloramphenicol	8-23	eukaryotic translation initiation factor 2, subunit 1 alpha	Mus musculus	94-99
33165592-5	2020	Herein, chloramphenicol, which inhibits mitochondrial DNA-encoded protein expression, induced eIF2a phosphorylation and ATF4 induction, leading to ISR gene expression.	Chloramphenicol	8-23	activating transcription factor 4	Mus musculus	120-124
33165592-7	2020	Short hairpin RNA-based knockdown of ATF4 markedly inhibited the chloramphenicol-induced ISR gene expression.	Chloramphenicol	65-80	activating transcription factor 4	Mus musculus	37-41
33173316-2	2020	Transformation indicated that optrA and cfr were located on two different plasmids and both could be transferred to recipient strain, resulting in the increase of MICs of linezolid and chloramphenicol.	Chloramphenicol	185-200	chloramphenicol-florfenicol resistance protein, CFR	Enterococcus faecalis	40-43
32910860-5	2020	The cross-reactivity profile and validation data for the detection of these amphenicols is presented together with results obtained following the analysis of florfenicol incurred samples using the developed screening method along with a comparison of results obtained from the analysis of the same incurred samples using an MRM3 UPLC-MS/MS confirmatory method.	Chloramphenicol	76-87	mitochondrial rRNA methyltransferase 3	Bos taurus	324-328
32514850-1	2020	A fluorescence method for the quantitative detection of chloramphenicol (CAP) has been developed using phosphate and fluorescent dye 6-carboxy-x-rhodamine (ROX) double-labeled aptamers of CAP and the bimetallic organic framework nanomaterial Cu/UiO-66.	Chloramphenicol	56-71	ribosomal oxygenase 1	Homo sapiens	156-159
32383849-4	2020	Nanoparticles of a peptide-lipid conjugate, being a substrate of enterokinase (ENTK), encapsulate chloramphenicol (CLRP), a clinically used antibiotic that is deactivated by glucuronidases in cytosol, but not in mitochondria.	Chloramphenicol	98-113	transmembrane serine protease 15	Homo sapiens	65-77
32383849-4	2020	Nanoparticles of a peptide-lipid conjugate, being a substrate of enterokinase (ENTK), encapsulate chloramphenicol (CLRP), a clinically used antibiotic that is deactivated by glucuronidases in cytosol, but not in mitochondria.	Chloramphenicol	98-113	transmembrane serine protease 15	Homo sapiens	79-83
32383849-4	2020	Nanoparticles of a peptide-lipid conjugate, being a substrate of enterokinase (ENTK), encapsulate chloramphenicol (CLRP), a clinically used antibiotic that is deactivated by glucuronidases in cytosol, but not in mitochondria.	Chloramphenicol	115-119	transmembrane serine protease 15	Homo sapiens	65-77
32383849-4	2020	Nanoparticles of a peptide-lipid conjugate, being a substrate of enterokinase (ENTK), encapsulate chloramphenicol (CLRP), a clinically used antibiotic that is deactivated by glucuronidases in cytosol, but not in mitochondria.	Chloramphenicol	115-119	transmembrane serine protease 15	Homo sapiens	79-83
31669805-1	2020	In this study, modified hollow titanium dioxide and SnS2 quantum dots (SnS2 QDs) were used to build a novel electrochemiluminescence immunoassay (ECLIA) for ultrasensitive detection of chloramphenicol (CAP).	Chloramphenicol	185-200	sodium voltage-gated channel alpha subunit 11	Homo sapiens	52-56
31958619-7	2020	Sensor responses are described as the decrease in the frequency of microbalances owing to chloramphenicol re-binding in the templated cavities, yielding a detection limit down to 0.74 muM.	Chloramphenicol	90-105	latexin	Homo sapiens	184-187
31940421-6	2020	To elucidate the effect of T3 on this non-linear regulation, we fused the GATA-REs at -3.9 kb or +9.5 kb of the GATA2 gene with the chloramphenicol acetyltransferase reporter gene harbored in its 1S-promoter.	Chloramphenicol	132-147	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	Mus musculus	74-78
31940421-6	2020	To elucidate the effect of T3 on this non-linear regulation, we fused the GATA-REs at -3.9 kb or +9.5 kb of the GATA2 gene with the chloramphenicol acetyltransferase reporter gene harbored in its 1S-promoter.	Chloramphenicol	132-147	GATA binding protein 2	Mus musculus	112-117
31669805-1	2020	In this study, modified hollow titanium dioxide and SnS2 quantum dots (SnS2 QDs) were used to build a novel electrochemiluminescence immunoassay (ECLIA) for ultrasensitive detection of chloramphenicol (CAP).	Chloramphenicol	185-200	sodium voltage-gated channel alpha subunit 11	Homo sapiens	71-75
31669805-1	2020	In this study, modified hollow titanium dioxide and SnS2 quantum dots (SnS2 QDs) were used to build a novel electrochemiluminescence immunoassay (ECLIA) for ultrasensitive detection of chloramphenicol (CAP).	Chloramphenicol	202-205	sodium voltage-gated channel alpha subunit 11	Homo sapiens	71-75
31505362-7	2020	The presence of ARGs encoding resistance to amphenicols, beta-lactams, and tetracyclines were associated with the higher concentrations of ciprofloxacin, enrofloxacin and sulfamethoxazole in irrigated fields.	Chloramphenicol	44-55	serpin family A member 2 (gene/pseudogene)	Homo sapiens	16-20
32275490-1	2020	OBJECTIVE: The main aim of the present work is to synthesize chloramphenicol impurity A (CLRM-IMP-A) in the purest form and its subsequent characterization by using a panel of sophisticated analytical techniques (LCMS, DSC, TGA, NMR, FTIR, HPLC and CHNS) to provide as reference standard mentioned in most of the international compendiums including IP, BP, USP, and EP.	Chloramphenicol	61-76	desmocollin 3	Homo sapiens	219-222
32275490-1	2020	OBJECTIVE: The main aim of the present work is to synthesize chloramphenicol impurity A (CLRM-IMP-A) in the purest form and its subsequent characterization by using a panel of sophisticated analytical techniques (LCMS, DSC, TGA, NMR, FTIR, HPLC and CHNS) to provide as reference standard mentioned in most of the international compendiums including IP, BP, USP, and EP.	Chloramphenicol	61-76	T-box transcription factor 1	Homo sapiens	224-227
31797114-6	2019	After optimization, the detection limit for CAP is 10 pg mL-1, which is three times less that of a conventional assay (30 pg mL-1).	Chloramphenicol	44-47	L1 cell adhesion molecule	Mus musculus	57-61
31689072-2	2019	To alter the effector specificity of XylS, we developed a dual selection system in Escherichia coli, which consists of (i) an artificial operon of an ampicillin resistance gene and tetR under Pm promoter control and (ii) a chloramphenicol resistance gene under tetR promoter control.	Chloramphenicol	223-238	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	37-41
31797114-6	2019	After optimization, the detection limit for CAP is 10 pg mL-1, which is three times less that of a conventional assay (30 pg mL-1).	Chloramphenicol	44-47	L1 cell adhesion molecule	Mus musculus	125-129
31764352-4	2019	QUESTIONS/PURPOSES: Using human OA knee chondrocytes in vitro, we asked, does chloramphenicol (1) activate autophagy in chondrocytes; (2) protect chondrocytes from IL-1beta-induced apoptosis; and (3) reduce the expression of matrix metallopeptidase (MMP)-13 and IL-6 (markers associated with articular cartilage degradation and joint inflammation).	Chloramphenicol	78-93	interleukin 1 beta	Homo sapiens	164-172
31764352-4	2019	QUESTIONS/PURPOSES: Using human OA knee chondrocytes in vitro, we asked, does chloramphenicol (1) activate autophagy in chondrocytes; (2) protect chondrocytes from IL-1beta-induced apoptosis; and (3) reduce the expression of matrix metallopeptidase (MMP)-13 and IL-6 (markers associated with articular cartilage degradation and joint inflammation).	Chloramphenicol	78-93	matrix metallopeptidase 13	Homo sapiens	225-257
31764352-4	2019	QUESTIONS/PURPOSES: Using human OA knee chondrocytes in vitro, we asked, does chloramphenicol (1) activate autophagy in chondrocytes; (2) protect chondrocytes from IL-1beta-induced apoptosis; and (3) reduce the expression of matrix metallopeptidase (MMP)-13 and IL-6 (markers associated with articular cartilage degradation and joint inflammation).	Chloramphenicol	78-93	interleukin 6	Homo sapiens	262-266
31764352-5	2019	Using an in vivo rabbit model of OA, we asked, does an intra-articular injection of chloramphenicol in the knee (4) induce autophagy; (5) reduce OA severity; and (6) reduce MMP-13 expression?	Chloramphenicol	84-99	collagenase 3	Oryctolagus cuniculus	173-179
31764352-19	2019	Chloramphenicol inhibited IL-1-induced apoptosis (flow cytometry results with chloramphenicol, 25.33 +- 3.51%, and without chloramphenicol, 44.00 +- 3.61%, mean difference, 18.67% [95% CI 10.60 to 26.73]; p = 0.003) and the production of proinflammatory cytokine IL-6 (ELISA results, with chloramphenicol, 720.00 +- 96.44 pg/mL, without chloramphenicol, 966.67 +- 85.05 pg/mL; mean difference 74.24 pg/mL [95% CI 39.28 to 454.06]; p = 0.029) in chondrocytes.	Chloramphenicol	0-15	interleukin-6	Oryctolagus cuniculus	263-267
31764352-21	2019	Furthermore, chloramphenicol treatment also decreased the production of MMP-13 in vitro and in vivo.	Chloramphenicol	13-28	collagenase 3	Oryctolagus cuniculus	72-78
31764352-22	2019	CONCLUSIONS: Chloramphenicol reduced the severity of cartilage degradation in a type II collagen-induced rabbit model of OA, which may be related to induction of autophagy and inhibition of MMP-13 and IL-6.	Chloramphenicol	13-28	collagenase 3	Oryctolagus cuniculus	190-196
31764352-22	2019	CONCLUSIONS: Chloramphenicol reduced the severity of cartilage degradation in a type II collagen-induced rabbit model of OA, which may be related to induction of autophagy and inhibition of MMP-13 and IL-6.	Chloramphenicol	13-28	interleukin-6	Oryctolagus cuniculus	201-205
31176150-6	2019	Under optimal conditions, the chemiluminescence intensity decreased linearly with the logarithm of the chloramphenicol concentration in the range of 0.0001 to 100 ng mL-1 and the detection limit (3sigma) was 0.033 pg mL-1.	Chloramphenicol	103-118	L1 cell adhesion molecule	Mus musculus	166-170
31176150-6	2019	Under optimal conditions, the chemiluminescence intensity decreased linearly with the logarithm of the chloramphenicol concentration in the range of 0.0001 to 100 ng mL-1 and the detection limit (3sigma) was 0.033 pg mL-1.	Chloramphenicol	103-118	L1 cell adhesion molecule	Mus musculus	217-221
31531120-5	2019	The results showed that 50 mug mL-1 and 100 mug mL-1 NG rescued and increased the thrombocytes numbers induced by vinorelbine (NVB) and chloramphenicol (CHL) and the erythrocytes numbers induced by methotrexate (MTX), doxorubicin (ADM), and mechlorethamine hydrochloride (MH) in zebrafish models.	Chloramphenicol	136-151	L1 cell adhesion molecule	Mus musculus	31-43
31636704-0	2019	Single mutation at a highly conserved region of chloramphenicol acetyltransferase enables isobutyl acetate production directly from cellulose by Clostridium thermocellum at elevated temperatures.	Chloramphenicol	48-63	AT695_RS00965	Staphylococcus aureus	64-81
31636704-6	2019	Results: In this study, we engineered a thermostable chloramphenicol acetyltransferase from Staphylococcus aureus (CATSa) for enhanced isobutyl acetate production at elevated temperatures.	Chloramphenicol	53-68	AT695_RS00965	Staphylococcus aureus	69-86
31531120-5	2019	The results showed that 50 mug mL-1 and 100 mug mL-1 NG rescued and increased the thrombocytes numbers induced by vinorelbine (NVB) and chloramphenicol (CHL) and the erythrocytes numbers induced by methotrexate (MTX), doxorubicin (ADM), and mechlorethamine hydrochloride (MH) in zebrafish models.	Chloramphenicol	153-156	L1 cell adhesion molecule	Mus musculus	31-43
31133049-7	2019	At high but nontoxic concentrations of each antibiotic, only chloramphenicol treatment of the Burkitt"s lymphoma cell line CA46 showed enhanced cytotoxicity when paired with an anti-transferrin receptor/PE RIT.	Chloramphenicol	61-76	transferrin	Homo sapiens	182-193
31282654-7	2019	To evaluate universality, we successfully detected chloramphenicol, with IC50 of 0.42 ng mL-1.	Chloramphenicol	51-66	L1 cell adhesion molecule	Mus musculus	89-93
30113702-6	2018	(+)-M5 formation in DLMs from (+)-M1 was potently inhibited by sulfaphenazole (CYP2C inhibitor) and chloramphenicol (CYP2B11 inhibitor) and was greatly increased in DLMs from phenobarbital-treated dogs.	Chloramphenicol	100-115	cytochrome P450 2B11	Canis lupus familiaris	117-124
30689880-4	2019	Primers were designed to detect 18 chloramphenicol resistance genes that produce seven distinct peaks correlating with different gene groups (catA1, catA2, catA3, catB2, catB group 3, cmlA and floR) following HRM analysis.	Chloramphenicol	35-50	hypothetical protein	Escherichia coli	142-147
30689880-4	2019	Primers were designed to detect 18 chloramphenicol resistance genes that produce seven distinct peaks correlating with different gene groups (catA1, catA2, catA3, catB2, catB group 3, cmlA and floR) following HRM analysis.	Chloramphenicol	35-50	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	193-197
30357604-7	2019	Tetracycline (tet (A)) and chloramphenicol (cml (A)) genes were the most predominant encoding resistance genes identified (50%) each, followed by gentamycin resistance encoding gene (aac (3)-IV) (37.5%).	Chloramphenicol	27-42	chloramphenicol resistance protein	Escherichia coli	44-51
30609861-0	2019	Chloramphenicol Induces Autophagy and Inhibits the Hypoxia Inducible Factor-1 Alpha Pathway in Non-Small Cell Lung Cancer Cells.	Chloramphenicol	0-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-83
30609861-4	2019	In this study, chloramphenicol was found to repress the oxygen-labile transcription factor, hypoxia inducible factor-1 alpha (HIF-1alpha), in hypoxic A549 and H1299 cells.	Chloramphenicol	15-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-124
30609861-4	2019	In this study, chloramphenicol was found to repress the oxygen-labile transcription factor, hypoxia inducible factor-1 alpha (HIF-1alpha), in hypoxic A549 and H1299 cells.	Chloramphenicol	15-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136
30609861-6	2019	Chloramphenicol initiated the autophagy pathway in treated cells, as observed by the increase in formation of Atg12-Atg5 conjugates, and in beclin-1 and LC3-II levels.	Chloramphenicol	0-15	autophagy related 12	Homo sapiens	110-115
30609861-6	2019	Chloramphenicol initiated the autophagy pathway in treated cells, as observed by the increase in formation of Atg12-Atg5 conjugates, and in beclin-1 and LC3-II levels.	Chloramphenicol	0-15	autophagy related 5	Homo sapiens	116-120
30609861-6	2019	Chloramphenicol initiated the autophagy pathway in treated cells, as observed by the increase in formation of Atg12-Atg5 conjugates, and in beclin-1 and LC3-II levels.	Chloramphenicol	0-15	beclin 1	Homo sapiens	140-148
30609861-9	2019	Chloramphenicol inhibited HIF-1alpha/SENP-1 protein interaction, thereby destabilizing HIF-1alpha protein.	Chloramphenicol	0-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-36
30609861-9	2019	Chloramphenicol inhibited HIF-1alpha/SENP-1 protein interaction, thereby destabilizing HIF-1alpha protein.	Chloramphenicol	0-15	SUMO specific peptidase 1	Homo sapiens	37-43
30609861-9	2019	Chloramphenicol inhibited HIF-1alpha/SENP-1 protein interaction, thereby destabilizing HIF-1alpha protein.	Chloramphenicol	0-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
30609861-10	2019	The enhancement in HIF-1alpha degradation due to chloramphenicol was evident during the incubation of the antibiotic before hypoxia and after HIF-1alpha accumulation.	Chloramphenicol	49-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
30609861-11	2019	Since HIF-1alpha plays multiple roles in infections, inflammation, and cancer cell stemness, our findings suggest a potential clinical value of chloramphenicol in the treatment of these conditions.	Chloramphenicol	144-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	6-16
29959905-4	2019	Additionally, CXCL14-C17 analogs showed much greater synergistic effect (FICI: 0.3125-0.375) with chloramphenicol and ciprofloxacin against multidrug-resistant Pseudomonas aeruginosa (MDRPA) than LL-37 did (FICI: 0.75-1.125).	Chloramphenicol	98-113	chemokine (C-X-C motif) ligand 14	Mus musculus	14-20
29959905-4	2019	Additionally, CXCL14-C17 analogs showed much greater synergistic effect (FICI: 0.3125-0.375) with chloramphenicol and ciprofloxacin against multidrug-resistant Pseudomonas aeruginosa (MDRPA) than LL-37 did (FICI: 0.75-1.125).	Chloramphenicol	98-113	cytokine like 1	Homo sapiens	21-24
29842974-10	2018	Chloramphenicol (catA1 and cmlA) and erythromycin [ere(A)] resistance genes showed prevalences of 72% and 15%, respectively, whereas gentamicin [aac(3)-IV], streptomycin (aadA1) and sulfonamide (sul1) resistance genes were detected in 20%, 20% and 10% of the studied isolates, respectively.	Chloramphenicol	0-15	hypothetical protein	Escherichia coli	17-22
29842974-10	2018	Chloramphenicol (catA1 and cmlA) and erythromycin [ere(A)] resistance genes showed prevalences of 72% and 15%, respectively, whereas gentamicin [aac(3)-IV], streptomycin (aadA1) and sulfonamide (sul1) resistance genes were detected in 20%, 20% and 10% of the studied isolates, respectively.	Chloramphenicol	0-15	AadA1	Escherichia coli	171-176
29842974-10	2018	Chloramphenicol (catA1 and cmlA) and erythromycin [ere(A)] resistance genes showed prevalences of 72% and 15%, respectively, whereas gentamicin [aac(3)-IV], streptomycin (aadA1) and sulfonamide (sul1) resistance genes were detected in 20%, 20% and 10% of the studied isolates, respectively.	Chloramphenicol	0-15	dihydropteroate synthase	Escherichia coli	195-199
30389403-11	2019	Pharmacological inhibition of de novo mitochondrial protein translation with chloramphenicol caused reversal of mitochondrial morphology in homozygous mutant MEFs, supporting the relevance of mitochondrial proteotoxicity for SCA28 pathogenesis and therapy development.	Chloramphenicol	77-92	AFG3 like matrix AAA peptidase subunit 2	Homo sapiens	225-230
30914972-8	2019	Incubation of sperm with mitochondrial translation inhibitor (D-chloramphenicol) suppressed mitochondrial protein synthesis, mitochondrial activity and ATP level in sperm and consequently reduced the linear motility speed, but not the motility.	Chloramphenicol	62-79	ATPase phospholipid transporting 8A2	Homo sapiens	152-155
28915374-0	2017	Enhanced degradation of chloramphenicol at alkaline conditions by S(-II) assisted heterogeneous Fenton-like reactions using pyrite.	Chloramphenicol	24-39	transcription elongation factor A1	Homo sapiens	66-71
29990817-1	2018	In this study, a cobalt-phosphorous/oxide (CoP/O) composite prepared via a one-step electrodeposition was for the first time applied in electroreductive dechlorination of halogenated antibiotics (HA), including chloramphenicol (CAP), florfenicol (FLO) and thiamphenicol (TAP).	Chloramphenicol	211-226	caspase recruitment domain family member 16	Homo sapiens	43-46
29990817-1	2018	In this study, a cobalt-phosphorous/oxide (CoP/O) composite prepared via a one-step electrodeposition was for the first time applied in electroreductive dechlorination of halogenated antibiotics (HA), including chloramphenicol (CAP), florfenicol (FLO) and thiamphenicol (TAP).	Chloramphenicol	228-231	caspase recruitment domain family member 16	Homo sapiens	43-46
29029160-0	2018	Characterization of the Actinobacillus pleuropneumoniae SXT-related integrative and conjugative element ICEApl2 and analysis of the encoded FloR protein: hydrophobic residues in transmembrane domains contribute dynamically to florfenicol and chloramphenicol efflux.	Chloramphenicol	242-257	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	140-144
29029160-9	2018	ICEApl2 encodes the antimicrobial resistance genes floR, strAB, sul2 and dfrA1, and MIDG3553 is resistant to streptomycin, sulfisoxazole and trimethoprim, but not florfenicol or chloramphenicol.	Chloramphenicol	178-193	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	51-55
29029160-10	2018	Cloning and site-directed mutagenesis of the floR gene revealed the importance of the nature of the hydrophobic amino acid residues at positions 160 and 228 in FloR for determining resistance to florfenicol and chloramphenicol.	Chloramphenicol	211-226	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	45-49
29029160-10	2018	Cloning and site-directed mutagenesis of the floR gene revealed the importance of the nature of the hydrophobic amino acid residues at positions 160 and 228 in FloR for determining resistance to florfenicol and chloramphenicol.	Chloramphenicol	211-226	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	160-164
29029160-11	2018	Conclusions: Our results indicate that the nature of hydrophobic residues at positions 160 and 228 of FloR contribute dynamically to specific efflux of florfenicol and chloramphenicol, although some differences in resistance levels may depend on the bacterial host species.	Chloramphenicol	168-183	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	102-106
29778528-3	2018	A great synergistic effect was observed during determination of FIC where molecules were used in combination with reference drugs chloramphenicol and sulfamethoxazole.	Chloramphenicol	130-145	C-C motif chemokine ligand 7	Homo sapiens	64-67
29857566-0	2018	Detection of beta-Lactams and Chloramphenicol Residues in Raw Milk-Development and Application of an HPLC-DAD Method in Comparison with Microbial Inhibition Assays.	Chloramphenicol	30-45	Weaning weight-maternal milk	Bos taurus	62-66
28922623-2	2017	Antisera and an enzyme-tracer for chloramphenicol were prepared and used to develop an ELISA with inhibition concentrations, IC20 and IC50, of 0.09 and 0.44 ng mL-1, respectively.	Chloramphenicol	34-49	L1 cell adhesion molecule	Mus musculus	160-164
28910068-4	2017	When molecular recognition by a DNA aptamer was incorporated into this method, visual detection of chloramphenicol was also achieved with a detection limit of 5 muM.	Chloramphenicol	99-114	latexin	Homo sapiens	161-164
28778689-8	2017	KEY FINDINGS: CAP treatment induced autophagy, increased phosphorylation of Erk1/2 in the myocardium and significantly reduced infarct size and CK release.	Chloramphenicol	14-17	mitogen activated protein kinase 3	Rattus norvegicus	76-82
28642068-0	2017	Chloramphenicol decreases CB1 receptor expression in the nucleus accumbens and prefrontal cortex and prevents amphetamine-induced conditioned place preference in rats.	Chloramphenicol	0-15	cannabinoid receptor 1	Rattus norvegicus	26-29
28437230-4	2017	Different variants of bla, tet, flo, dfrA, and aadA genes were detected in most of the strains resistant to beta-lactam, tetracycline, chloramphenicol, sulfonamides, and aminoglycosides, respectively.	Chloramphenicol	135-150	beta-lactamase	Escherichia coli	22-25
28527697-5	2017	However, chloramphenicol efficiently reduced mitochondrial protein synthesis in INS-1E cells, lowering expression of the mtDNA encoded COX1 subunit of the respiratory chain but not the nuclear encoded ATP-synthase subunit ATP5A.	Chloramphenicol	9-24	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	135-139
28549777-6	2017	Furthermore, MEFs treated with chloramphenicol, an inhibitor of mitochondrial translation, produced excessive IL-6 via ATF4 pathways.	Chloramphenicol	31-46	interleukin 6	Mus musculus	110-114
28630449-8	2017	For some of the Fab gene variants, we also observed striking differences in protein yields when cloned from a chloramphenicol resistant vector into an identical vector, except with ampicillin resistance.	Chloramphenicol	110-125	FA complementation group B	Homo sapiens	16-19
28549777-6	2017	Furthermore, MEFs treated with chloramphenicol, an inhibitor of mitochondrial translation, produced excessive IL-6 via ATF4 pathways.	Chloramphenicol	31-46	activating transcription factor 4	Mus musculus	119-123
28161291-0	2017	LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity.	Chloramphenicol	112-127	cathelicidin antimicrobial peptide	Homo sapiens	0-5
28340736-0	2017	Highly sensitive electrochemical sensor for chloramphenicol based on MOF derived exfoliated porous carbon.	Chloramphenicol	44-59	lysine acetyltransferase 8	Homo sapiens	69-72
28764183-1	2017	Acquired coagulation factor VIII inhibitor leads to a rare disease i.e., acquired haemophilia which is idiopathic in majority of cases and is seen with autoimmune diseases, haematologic and solid tumours, infections, in the post-partum period and also with certain long-term use of drugs like penicillin and its derivatives, phenytoin, sulfa antibiotics, chloramphenicol, methyldopa, chlorpromazine, levodopa, interferon-alpha, fludarabine, clopidogrel.	Chloramphenicol	355-370	coagulation factor VIII	Homo sapiens	9-32
28368045-6	2017	In detail, the adsorption capacities of CNF/GO aerogel were 418.7 mg g-1 for chloramphenicol, 291.8 mg g-1 for macrolides, 128.3 mg g-1 for quinolones, 230.7 mg g-1 for beta-Lactams, 227.3 mg g-1 for sulfonamides, and 454.6 mg g-1 for tetracyclines calculated by the Langmuir isotherm models.	Chloramphenicol	77-92	NPHS1 adhesion molecule, nephrin	Homo sapiens	40-43
28532791-1	2017	A small (3.9kb) plasmid (p518), conferring resistance to florfenicol (MIC &gt;8mug/mL) and chloramphenicol (MIC &gt;8mug/mL) was isolated from an Actinobacillus pleuropneumoniae clinical isolate from Southeastern Brazil.	Chloramphenicol	91-106	pyroglutamylated RFamide peptide	Homo sapiens	25-29
28228532-10	2017	Ugt2b1 and 2b5 were the only isoforms involved in chloramphenicol glucuronidation.	Chloramphenicol	50-65	UDP glucuronosyltransferase 2 family, polypeptide B1	Mus musculus	0-6
28242423-6	2017	With this idea, LNMMA, the iNOS inhibitor is used along with antibiotics Ofloxacin or Chloramphenicol on S. aureus infected mouse peritoneal macrophage.	Chloramphenicol	86-101	nitric oxide synthase 2, inducible	Mus musculus	27-31
27807702-6	2017	This capacitation-associated increase in ATP1A4 content was partially decreased by chloramphenicol (mitochondrial translation inhibitor) but not affected by actinomycin D (transcription inhibitor).	Chloramphenicol	83-98	ATPase Na+/K+ transporting subunit alpha 4	Bos taurus	41-47
27807702-8	2017	A partial decrease in bodipy-lysine incorporation occurred in ATP1A4 from sperm capacitated in the presence of chloramphenicol.	Chloramphenicol	111-126	ATPase Na+/K+ transporting subunit alpha 4	Bos taurus	62-68
27596250-2	2017	The FRET switch was synthesized by connecting SSB labeled quantum dots (QDs@SSB) as donor with aptamer (apt) labeled gold nanoparticles (AuNPs@apt) as acceptor, and it was employed for detecting chloramphenicol (CAP) in a homogenous solution.	Chloramphenicol	195-210	replication protein A1	Homo sapiens	46-49
27566885-9	2017	Co-located resistance to sulfonamides, tetracycline, trimethoprim, and chloramphenicol/florfenicol was detected on five ESBL gene-carrying plasmids, but seven plasmids conferred solely resistance to beta-lactam antibiotics.	Chloramphenicol	71-86	EsbL	Escherichia coli	120-124
27596250-2	2017	The FRET switch was synthesized by connecting SSB labeled quantum dots (QDs@SSB) as donor with aptamer (apt) labeled gold nanoparticles (AuNPs@apt) as acceptor, and it was employed for detecting chloramphenicol (CAP) in a homogenous solution.	Chloramphenicol	195-210	replication protein A1	Homo sapiens	76-79
28184339-9	2017	The statistical analysis showed that the esp infective gene has significant associations with ciprofloxacin, erythromycin and tetracycline in E. faecium and with chloramphenicol in E. faecalis strains; the hyl with teicoplanin and vancomycin in E. faecium strains; and also asa1 with vancomycin in E. faecium and with ampicillin and chloramphenicol in E. faecalis strains.	Chloramphenicol	162-177	aggregation substance	Enterococcus faecalis	274-278
27788606-4	2016	Ovalbumin-immunized Kunming mice were gavaged daily with amphenicols for seven days.	Chloramphenicol	57-68	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-9
26375469-0	2015	Chloramphenicol Selection of IS10 Transposition in the cat Promoter Region of Widely Used Cloning Vectors.	Chloramphenicol	0-15	chloramphenicol acetyltransferase	Escherichia coli	55-58
27600040-5	2016	MBL producers were resistant to all antibiotics tested except for colistin, fosfomycin, and chloramphenicol, which were effective to various extents.	Chloramphenicol	92-107	NDM-1	Escherichia coli	0-3
27668828-1	2016	The first step in the nonribosomal peptide synthetase (NRPS)-based biosynthesis of chloramphenicol is the beta-hydroxylation of the precursor l-p-aminophenylalanine (l-PAPA) catalyzed by the monooxygenase CmlA.	Chloramphenicol	83-98	pappalysin 1	Homo sapiens	168-172
26375469-1	2015	The widely used pSU8 family of cloning vectors is based on a p15A replicon and a chloramphenicol acetyltransferase (cat) gene conferring chloramphenicol resistance.	Chloramphenicol	81-96	chloramphenicol acetyltransferase	Escherichia coli	116-119
26023209-0	2015	Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two "old" antibiotics-polymyxin B and chloramphenicol.	Chloramphenicol	104-119	NDM-1	Klebsiella pneumoniae	23-26
26023209-2	2015	This study systematically investigated bacterial killing and the emergence of polymyxin resistance with polymyxin B and chloramphenicol combinations used against New Delhi metallo-beta-lactamase (NDM)-producing MDR Klebsiella pneumoniae.	Chloramphenicol	120-135	NDM-1	Klebsiella pneumoniae	162-194
26023209-2	2015	This study systematically investigated bacterial killing and the emergence of polymyxin resistance with polymyxin B and chloramphenicol combinations used against New Delhi metallo-beta-lactamase (NDM)-producing MDR Klebsiella pneumoniae.	Chloramphenicol	120-135	NDM-1	Klebsiella pneumoniae	196-199
26023209-12	2015	CONCLUSIONS: The combination of polymyxin B and chloramphenicol used against NDM-producing MDR K. pneumoniae substantially enhanced bacterial killing and suppressed the emergence of polymyxin resistance.	Chloramphenicol	48-63	NDM-1	Klebsiella pneumoniae	77-80
26145148-0	2015	Inverse Temperature Dependence in Static Quenching versus Calorimetric Exploration: Binding Interaction of Chloramphenicol to beta-Lactoglobulin.	Chloramphenicol	107-122	beta-lactoglobulin	Bos taurus	126-144
26230088-10	2015	Overexpression of mexEF-oprN operon in desB mutant was phenotypically confirmed by observing significantly increased resistance to chloramphenicol.	Chloramphenicol	131-146	acyl-CoA desaturase	Pseudomonas aeruginosa PAO1	39-43
26081601-2	2015	In this study, the interaction between the lantibiotic bovicin HC5 with chloramphenicol, gentamicin, nisin, lysostaphin and hydrogen peroxide against Staphylococcus aureus O46 was evaluated by MIC assays.	Chloramphenicol	72-87	CYCS pseudogene 1	Homo sapiens	63-66
26081601-5	2015	However, bovicin HC5 showed a significant interaction (P &lt; 0.02) with chloramphenicol.	Chloramphenicol	73-88	CYCS pseudogene 1	Homo sapiens	17-20
26145148-1	2015	The binding interaction between the whey protein bovine beta-lactoglobulin (betaLG) with the well-known antibiotic chloramphenicol (Clp) is explored by monitoring the intrinsic fluorescence of betaLG.	Chloramphenicol	115-130	beta-lactoglobulin	Bos taurus	56-74
26145148-1	2015	The binding interaction between the whey protein bovine beta-lactoglobulin (betaLG) with the well-known antibiotic chloramphenicol (Clp) is explored by monitoring the intrinsic fluorescence of betaLG.	Chloramphenicol	132-135	beta-lactoglobulin	Bos taurus	56-74
24080654-2	2013	Interestingly, subinhibitory concentrations of chloramphenicol in combination with heat stress, as well as linezolid and spectinomycin at physiological temperatures, selected for such rsbU::IS256 insertion mutants.	Chloramphenicol	47-62	IS256, transposase	Staphylococcus aureus	190-195
25783628-7	2015	CAT(A138T) conferred chloramphenicol resistance to G. kaustophilus cells at high temperature more efficiently than CAT.	Chloramphenicol	21-36	CAT	Staphylococcus aureus	0-3
25907584-4	2015	We found that both ppk mutants shared most of the phenotypic changes and interestingly many of them related to susceptibility toward numerous and different type of antibiotics such as Ciprofloxacin, Chloramphenicol and Rifampicin.	Chloramphenicol	199-214	polyphosphate kinase	Pseudomonas aeruginosa PAO1	19-22
25876327-4	2014	RESULTS: PA2580 mutant was more sensitive to carbenicillin, chloramphenicol and ciprofloxacin.	Chloramphenicol	60-75	hypothetical protein	Pseudomonas aeruginosa PAO1	9-15
25267678-1	2014	Comparative genome analysis revealed seven uncharacterized genes, sven0909 to sven0915, adjacent to the previously identified chloramphenicol biosynthetic gene cluster (sven0916-sven0928) of Streptomyces venezuelae strain ATCC 10712 that was absent in a closely related Streptomyces strain that does not produce chloramphenicol.	Chloramphenicol	126-141	SVEN_RS04435	Streptomyces venezuelae ATCC 10712	169-177
25267678-1	2014	Comparative genome analysis revealed seven uncharacterized genes, sven0909 to sven0915, adjacent to the previously identified chloramphenicol biosynthetic gene cluster (sven0916-sven0928) of Streptomyces venezuelae strain ATCC 10712 that was absent in a closely related Streptomyces strain that does not produce chloramphenicol.	Chloramphenicol	126-141	SVEN_RS04495	Streptomyces venezuelae ATCC 10712	178-186
25267678-1	2014	Comparative genome analysis revealed seven uncharacterized genes, sven0909 to sven0915, adjacent to the previously identified chloramphenicol biosynthetic gene cluster (sven0916-sven0928) of Streptomyces venezuelae strain ATCC 10712 that was absent in a closely related Streptomyces strain that does not produce chloramphenicol.	Chloramphenicol	312-327	SVEN_RS04405	Streptomyces venezuelae ATCC 10712	66-74
25267678-1	2014	Comparative genome analysis revealed seven uncharacterized genes, sven0909 to sven0915, adjacent to the previously identified chloramphenicol biosynthetic gene cluster (sven0916-sven0928) of Streptomyces venezuelae strain ATCC 10712 that was absent in a closely related Streptomyces strain that does not produce chloramphenicol.	Chloramphenicol	312-327	SVEN_RS04430	Streptomyces venezuelae ATCC 10712	78-86
25267678-1	2014	Comparative genome analysis revealed seven uncharacterized genes, sven0909 to sven0915, adjacent to the previously identified chloramphenicol biosynthetic gene cluster (sven0916-sven0928) of Streptomyces venezuelae strain ATCC 10712 that was absent in a closely related Streptomyces strain that does not produce chloramphenicol.	Chloramphenicol	312-327	SVEN_RS04435	Streptomyces venezuelae ATCC 10712	169-177
25267678-1	2014	Comparative genome analysis revealed seven uncharacterized genes, sven0909 to sven0915, adjacent to the previously identified chloramphenicol biosynthetic gene cluster (sven0916-sven0928) of Streptomyces venezuelae strain ATCC 10712 that was absent in a closely related Streptomyces strain that does not produce chloramphenicol.	Chloramphenicol	312-327	SVEN_RS04495	Streptomyces venezuelae ATCC 10712	178-186
25267678-4	2014	Bioinformatic analysis also revealed the presence of a previously undetected gene, sven0925, embedded within the chloramphenicol biosynthetic gene cluster that appears to encode an acyl carrier protein, bringing the number of new genes likely to be involved in chloramphenicol production to four.	Chloramphenicol	113-128	SVEN_RS04480	Streptomyces venezuelae ATCC 10712	83-91
25267678-4	2014	Bioinformatic analysis also revealed the presence of a previously undetected gene, sven0925, embedded within the chloramphenicol biosynthetic gene cluster that appears to encode an acyl carrier protein, bringing the number of new genes likely to be involved in chloramphenicol production to four.	Chloramphenicol	261-276	SVEN_RS04480	Streptomyces venezuelae ATCC 10712	83-91
25393060-0	2014	Detection and quantification of chloramphenicol in milk and honey using molecularly imprinted polymers: Canadian penny-based SERS nano-biosensor.	Chloramphenicol	32-47	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	125-129
25393060-1	2014	We integrated molecularly imprinted polymers with surface-enhanced Raman spectroscopy (MIPs-SERS) to develop an innovative nano-biosensor for the determination of chloramphenicol (CAP) in milk and honey products.	Chloramphenicol	163-178	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	92-96
25812222-9	2014	The presence of invA, avrA, ssaQ, mgtC, siiD, sopB and bcfC was associated with resistance to chloramphenicol; invA, sopB and bcfC with resistance to streptomycin and lincosamide; and invA and sodC1 with resistance to trimethoprim-sulfamethoxazole.	Chloramphenicol	94-109	plasmid-partitioning protein	Salmonella enterica subsp. enterica serovar Typhimurium	46-50
25812222-9	2014	The presence of invA, avrA, ssaQ, mgtC, siiD, sopB and bcfC was associated with resistance to chloramphenicol; invA, sopB and bcfC with resistance to streptomycin and lincosamide; and invA and sodC1 with resistance to trimethoprim-sulfamethoxazole.	Chloramphenicol	94-109	plasmid-partitioning protein	Salmonella enterica subsp. enterica serovar Typhimurium	117-121
25812224-6	2014	Carriage of invA, sopB and bcfC among the Enteritidis, Typhimurium, Virchow, Larochelle, Altona and non-typeable isolates was associated with a core pattern of resistance to three antibiotics: streptomycin, nalidixic acid and chloramphenicol.	Chloramphenicol	226-241	plasmid-partitioning protein	Salmonella enterica subsp. enterica serovar Typhimurium	18-22
24972115-6	2014	The detected genes were blaZ; erm(A)-erm(B)-erm(C)-msr(A)-msr(B)-lnu(A), aphA-aadE-sat4-aacA + aphD-aadD, tet(K), cat, and qacA/B, for resistance to ampicillin, macrolides and/or lincosamides, aminoglycosides, tetracycline, chloramphenicol, and quaternary ammonium compounds, respectively.	Chloramphenicol	224-239	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	24-28
25583746-9	2015	We found a higher mortality with chloramphenicol for respiratory tract infections [risk ratio (RR) 1.40, 95% CI 1.00-1.97] and meningitis (RR 1.27, 95% CI 1.00-1.60), both without heterogeneity.	Chloramphenicol	33-48	ribonucleotide reductase catalytic subunit M1	Homo sapiens	139-143
25583746-12	2015	This difference derived mainly from studies comparing chloramphenicol with fluoroquinolones (RR 1.85, 95% CI 1.07-3.2).	Chloramphenicol	54-69	ribonucleotide reductase catalytic subunit M1	Homo sapiens	93-97
25532298-9	2014	The combinations savory oil-chloramphenicol, savory oil-tetracycline and geraniol-chloramphenicol produced predominantly synergistic interactions (FIC indices in the range 0.21-0.87) and substantial reductions in the MIC values of antimicrobials against Gram-negative bacteria, the pharmacological treatment of which is very difficult nowadays.	Chloramphenicol	28-43	C-C motif chemokine ligand 7	Homo sapiens	147-150
25532298-9	2014	The combinations savory oil-chloramphenicol, savory oil-tetracycline and geraniol-chloramphenicol produced predominantly synergistic interactions (FIC indices in the range 0.21-0.87) and substantial reductions in the MIC values of antimicrobials against Gram-negative bacteria, the pharmacological treatment of which is very difficult nowadays.	Chloramphenicol	82-97	C-C motif chemokine ligand 7	Homo sapiens	147-150
24878559-0	2014	Potential toxicity of amphenicol antibiotic: binding of chloramphenicol to human serum albumin.	Chloramphenicol	22-32	albumin	Homo sapiens	81-94
24878559-0	2014	Potential toxicity of amphenicol antibiotic: binding of chloramphenicol to human serum albumin.	Chloramphenicol	56-71	albumin	Homo sapiens	81-94
24878559-2	2014	To evaluate the toxicity of chloramphenicol (CAP) at the protein level, the interaction between CAP and human serum albumin (HSA) was investigated by fluorescence, Ultraviolet-visible (UV-Vis) absorption, Fourier transform infrared (FT-IR) spectroscopy and molecular docking methods.	Chloramphenicol	28-43	albumin	Homo sapiens	110-123
23879707-2	2013	Resistance to tetracycline (tet(M)), chloramphenicol (cat) and macrolides (erm(B) and/or mef(A/E)) is generally conferred by acquisition of specific genes that are associated with mobile genetic elements, including those of the Tn916 and Tn5252 families.	Chloramphenicol	37-52	E74 like ETS transcription factor 4	Homo sapiens	89-92
23806146-10	2013	The toxin genes sec, seh, and enterotoxin gene cluster (egc) were significantly more prevalent among isolates of lineage ST9 (p&lt;0.001) compared to other lineages, and the ST9 isolates were more resistant to erythromycin, clindamycin, ciprofloxacin, chloramphenicol, and gentamicin.	Chloramphenicol	252-267	Enterotoxin	Staphylococcus aureus	30-41
23974000-5	2013	The optimized chloramphenicol-loaded nanoemulsion response values for particle size, PDI, zeta potential and osmolality were 95.33nm, 0.238, -36.91mV, and 200mOsm/kg, respectively.	Chloramphenicol	14-29	peptidyl arginine deiminase 1	Homo sapiens	85-88
23589299-2	2013	We found that doxycycline, chloramphenicol, and Geneticin (G418) interfered with insertion of selenocysteine (Sec), which is encoded by the stop codon, UGA, into selenoproteins in murine EMT6 cells.	Chloramphenicol	27-42	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	110-113
23632330-0	2013	Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol.	Chloramphenicol	92-107	taste 2 receptor member 41	Homo sapiens	52-59
23632330-7	2013	Chloramphenicol was identified as agonist for TAS2R41.	Chloramphenicol	0-15	taste 2 receptor member 41	Homo sapiens	46-53
23589299-5	2013	In the presence of doxycycline, chloramphenicol, or G418, the Sec-containing form of TR1 decreased, whereas the arginine-containing and truncated forms of this protein increased.	Chloramphenicol	32-47	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	62-65
23589299-5	2013	In the presence of doxycycline, chloramphenicol, or G418, the Sec-containing form of TR1 decreased, whereas the arginine-containing and truncated forms of this protein increased.	Chloramphenicol	32-47	thioredoxin reductase 1	Homo sapiens	85-88
23167761-0	2013	Chloramphenicol enhances IDUA activity on fibroblasts from mucopolysaccharidosis I patients.	Chloramphenicol	0-15	alpha-L-iduronidase	Homo sapiens	25-29
23295213-0	2013	Study on the binding of chloroamphenicol with bovine serum albumin by fluorescence and UV-vis spectroscopy.	Chloramphenicol	24-40	albumin	Homo sapiens	53-66
23295213-1	2013	The binding of chloroamphenicol (CPC) to bovine serum albumin (BSA) at 296 K, 303 K, and 310 K by fluorescence and UV-visible absorption spectroscopy were investigated under imitated physiological conditions.	Chloramphenicol	15-31	albumin	Homo sapiens	48-61
23295213-1	2013	The binding of chloroamphenicol (CPC) to bovine serum albumin (BSA) at 296 K, 303 K, and 310 K by fluorescence and UV-visible absorption spectroscopy were investigated under imitated physiological conditions.	Chloramphenicol	33-36	albumin	Homo sapiens	48-61
23374512-10	2013	RESULTS: The vancomycin-resistant isolate CP2 was found to be resistant to oxacillin, chloramphenicol, erythromycin, rifampicin, gentamicin, tetracycline and ciprofloxacin, as well.	Chloramphenicol	86-101	ceruloplasmin	Homo sapiens	42-45
22143519-5	2012	The analysis also revealed that an ABC extrusion system (PP2669/PP2668/PP2667) and the AgmR regulator (PP2665) were needed for full resistance toward chloramphenicol.	Chloramphenicol	150-165	response regulator transcription factor	Pseudomonas putida KT2440	87-91
22877757-5	2012	hPrx1 also acted as a transcription anti-terminator in an assay using an Escherichia coli strain containing a stem-loop structure upstream of the chloramphenicol resistance gene.	Chloramphenicol	146-161	peroxiredoxin 1	Homo sapiens	0-5
22576012-5	2012	Inhibition of mitochondrial protein synthesis either by ERAL1 siRNA or chloramphenicol (CAP), a specific inhibitor of mitoribosomes, induced autophagy in HTC-116 TP53 (+/+)  cells, but not in HTC-116 TP53 (-/-)  cells, indicating that tumor protein 53 (TP53) is essential for the autophagy induction.	Chloramphenicol	71-86	tumor protein p53	Homo sapiens	162-166
22576012-5	2012	Inhibition of mitochondrial protein synthesis either by ERAL1 siRNA or chloramphenicol (CAP), a specific inhibitor of mitoribosomes, induced autophagy in HTC-116 TP53 (+/+)  cells, but not in HTC-116 TP53 (-/-)  cells, indicating that tumor protein 53 (TP53) is essential for the autophagy induction.	Chloramphenicol	88-91	tumor protein p53	Homo sapiens	162-166
22576012-5	2012	Inhibition of mitochondrial protein synthesis either by ERAL1 siRNA or chloramphenicol (CAP), a specific inhibitor of mitoribosomes, induced autophagy in HTC-116 TP53 (+/+)  cells, but not in HTC-116 TP53 (-/-)  cells, indicating that tumor protein 53 (TP53) is essential for the autophagy induction.	Chloramphenicol	88-91	tumor protein p53	Homo sapiens	200-204
22576012-5	2012	Inhibition of mitochondrial protein synthesis either by ERAL1 siRNA or chloramphenicol (CAP), a specific inhibitor of mitoribosomes, induced autophagy in HTC-116 TP53 (+/+)  cells, but not in HTC-116 TP53 (-/-)  cells, indicating that tumor protein 53 (TP53) is essential for the autophagy induction.	Chloramphenicol	88-91	tumor protein p53	Homo sapiens	235-251
22576012-5	2012	Inhibition of mitochondrial protein synthesis either by ERAL1 siRNA or chloramphenicol (CAP), a specific inhibitor of mitoribosomes, induced autophagy in HTC-116 TP53 (+/+)  cells, but not in HTC-116 TP53 (-/-)  cells, indicating that tumor protein 53 (TP53) is essential for the autophagy induction.	Chloramphenicol	88-91	tumor protein p53	Homo sapiens	200-204
21820820-5	2012	The expression of floR gene in E. coli and inhibition studies with PAbetaN indicated that the floR gene was as an efflux pump conferring resistance to both chloramphenicol and florfenicol.	Chloramphenicol	156-171	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	18-22
21820820-5	2012	The expression of floR gene in E. coli and inhibition studies with PAbetaN indicated that the floR gene was as an efflux pump conferring resistance to both chloramphenicol and florfenicol.	Chloramphenicol	156-171	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	94-98
21457048-7	2011	The floR gene was detected in 57% of the florfenicol-resistant isolates and in 52% of chloramphenicol-resistant isolates.	Chloramphenicol	86-101	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	4-8
22054021-11	2011	The presence of stronger binding ligands, e.g., chloramphenicol, tetracyclines or diclofenac, can compete with chloroquine for its binding sites, and therefore lowers its serum albumin binding.	Chloramphenicol	48-63	albumin	Homo sapiens	171-184
21705546-1	2011	Salmonella genomic island 1 (SGI1) contains a multidrug resistance region conferring the ampicillin-chloramphenicol-streptomycin-sulfamethoxazole-tetracycline resistance phenotype encoded by bla(PSE-1), floR, aadA2, sul1, and tet(G).	Chloramphenicol	100-115	FloR	Salmonella enterica	203-207
22210605-0	2011	Characterization of two metagenome-derived esterases that reactivate chloramphenicol by counteracting chloramphenicol acetyltransferase.	Chloramphenicol	69-84	chloramphenicol acetyltransferase	Escherichia coli	102-135
22210605-3	2011	EstDL26 and EstDL136 reactivated chloramphenicol from its acetyl derivates by counteracting the chloramphenicol acetyltransferase (CAT) activity in Escherichia coli.	Chloramphenicol	33-48	chloramphenicol acetyltransferase	Escherichia coli	96-129
22210605-3	2011	EstDL26 and EstDL136 reactivated chloramphenicol from its acetyl derivates by counteracting the chloramphenicol acetyltransferase (CAT) activity in Escherichia coli.	Chloramphenicol	33-48	chloramphenicol acetyltransferase	Escherichia coli	131-134
22040436-3	2011	METHODS: Wild type CTB coding gene was amplified and cloned into prokaryotic expression vector pET-30a, and the recombinant CTB was expressed in the presence of different concentration of chloramphenicol and isopropyl beta-D-thiogalactoside.	Chloramphenicol	188-203	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	124-127
22040436-6	2011	RESULTS: Chloramphenicol was essential for the efficient expression of recombinant CTB (rCTB) in pET-30a/BL21 (DE3) system and could be optimized at the concentration of 0.625 microg/ml in the presence of chloramphenicol.	Chloramphenicol	9-24	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	83-86
22040436-6	2011	RESULTS: Chloramphenicol was essential for the efficient expression of recombinant CTB (rCTB) in pET-30a/BL21 (DE3) system and could be optimized at the concentration of 0.625 microg/ml in the presence of chloramphenicol.	Chloramphenicol	9-24	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	88-92
22040436-6	2011	RESULTS: Chloramphenicol was essential for the efficient expression of recombinant CTB (rCTB) in pET-30a/BL21 (DE3) system and could be optimized at the concentration of 0.625 microg/ml in the presence of chloramphenicol.	Chloramphenicol	205-220	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	83-86
22040436-6	2011	RESULTS: Chloramphenicol was essential for the efficient expression of recombinant CTB (rCTB) in pET-30a/BL21 (DE3) system and could be optimized at the concentration of 0.625 microg/ml in the presence of chloramphenicol.	Chloramphenicol	205-220	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	88-92
22040436-9	2011	CONCLUSION: CTB could be efficiently expressed in the presence of chloramphenicol and purified CTB is functional and capable of enhancing the specific T cell responses elicited by DNA vaccine, the mechanism needs to be explored in the future.	Chloramphenicol	66-81	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	12-15
20552314-4	2011	NF and GFAP directed flow cytometry was able to identify several of the test chemicals as being specifically neurotoxic (chloroquine, nicotine) or astrocytoxic (atropine, chloramphenicol) via quantification of cell death in the NT2.N/A model at cytotoxic concentrations using the resazurin cytotoxicity assay.	Chloramphenicol	171-186	glial fibrillary acidic protein	Homo sapiens	7-11
20703582-5	2011	Resistivity and sensitivity of the three antibiotics (ampicillin, chloramphenicol disks and trimethoprim-sulfamethoxazole) were classified with high accuracies by the PNN.	Chloramphenicol	66-81	pinin, desmosome associated protein	Homo sapiens	167-170
22046301-5	2011	We also generated a plaque assay to monitor the formation of lytic plaques over time and demonstrated that chloramphenicol accelerates host cell lysis of vapB/C-containing Rickettsia.	Chloramphenicol	107-122	VAMP associated protein B and C	Homo sapiens	154-158
20439409-5	2010	The lysate is incubated with [(14)C]chloramphenicol and acetyl-coenzyme A; CAT catalyzes the acetylation of chloramphenicol.	Chloramphenicol	36-51	chloramphenicol acetyltransferase	Escherichia coli	75-78
19728170-3	2010	The results showed that the chloramphenicol acetyltransferase was apparently expressed in K. pneumoniae, and the recombinant strain had a high-level resistance to chloramphenicol, suggesting that the promoter Pkan was efficient in K. pneumoniae.	Chloramphenicol	28-43	aminoglycoside 6'-N-acetyltransferase type Ib	Klebsiella pneumoniae	44-61
20713732-1	2010	The biosynthesis of chloramphenicol requires a beta-hydroxylation tailoring reaction of the precursor L-p-aminophenylalanine (L-PAPA).	Chloramphenicol	20-35	pappalysin 1	Homo sapiens	128-132
20650273-4	2010	The repressive effects of glucose and chloramphenicol on LHCB expression were inhibited in phxk (plastid hexokinase) mutant.	Chloramphenicol	38-53	hexokinase	Arabidopsis thaliana	105-115
20338993-10	2010	These findings suggest that chloramphenicol-induced PI-3K/Akt, JNK phosphorylation, and activator protein 1 activation might function as a novel mitochondrial stress signal that result in an increase of MMP-13 expression and MMP-13-associated cancer cell invasion.	Chloramphenicol	28-43	AKT serine/threonine kinase 1	Homo sapiens	58-61
20338993-10	2010	These findings suggest that chloramphenicol-induced PI-3K/Akt, JNK phosphorylation, and activator protein 1 activation might function as a novel mitochondrial stress signal that result in an increase of MMP-13 expression and MMP-13-associated cancer cell invasion.	Chloramphenicol	28-43	mitogen-activated protein kinase 8	Homo sapiens	63-66
20338993-10	2010	These findings suggest that chloramphenicol-induced PI-3K/Akt, JNK phosphorylation, and activator protein 1 activation might function as a novel mitochondrial stress signal that result in an increase of MMP-13 expression and MMP-13-associated cancer cell invasion.	Chloramphenicol	28-43	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-107
20338993-10	2010	These findings suggest that chloramphenicol-induced PI-3K/Akt, JNK phosphorylation, and activator protein 1 activation might function as a novel mitochondrial stress signal that result in an increase of MMP-13 expression and MMP-13-associated cancer cell invasion.	Chloramphenicol	28-43	matrix metallopeptidase 13	Homo sapiens	203-209
20338993-10	2010	These findings suggest that chloramphenicol-induced PI-3K/Akt, JNK phosphorylation, and activator protein 1 activation might function as a novel mitochondrial stress signal that result in an increase of MMP-13 expression and MMP-13-associated cancer cell invasion.	Chloramphenicol	28-43	matrix metallopeptidase 13	Homo sapiens	225-231
20539216-7	2010	VEGF and CD34 levels were significantly induced by chemical cauterization in the groups treated with chloramphenicol, chondroitin sulfate, and normal saline, demonstrating corneal NV.	Chloramphenicol	101-116	vascular endothelial growth factor A	Rattus norvegicus	0-4
20539216-7	2010	VEGF and CD34 levels were significantly induced by chemical cauterization in the groups treated with chloramphenicol, chondroitin sulfate, and normal saline, demonstrating corneal NV.	Chloramphenicol	101-116	CD34 molecule	Rattus norvegicus	9-13
20338993-0	2010	Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion.	Chloramphenicol	0-15	matrix metallopeptidase 13	Homo sapiens	81-108
20338993-4	2010	We found that chloramphenicol can induce matrix metalloproteinase (MMP)-13 expression and increase MMP-13 protein in conditioned medium, resulting in an increase in cancer cell invasion.	Chloramphenicol	14-29	matrix metallopeptidase 13	Homo sapiens	41-74
20338993-4	2010	We found that chloramphenicol can induce matrix metalloproteinase (MMP)-13 expression and increase MMP-13 protein in conditioned medium, resulting in an increase in cancer cell invasion.	Chloramphenicol	14-29	matrix metallopeptidase 13	Homo sapiens	99-105
20338993-5	2010	Chloramphenicol also activated c-Jun N-terminal kinases (JNK) and phosphatidylinositol 3-kinase (PI-3K)/Akt signaling, leading to c-Jun protein phosphorylation.	Chloramphenicol	0-15	mitogen-activated protein kinase 8	Homo sapiens	31-55
20338993-5	2010	Chloramphenicol also activated c-Jun N-terminal kinases (JNK) and phosphatidylinositol 3-kinase (PI-3K)/Akt signaling, leading to c-Jun protein phosphorylation.	Chloramphenicol	0-15	mitogen-activated protein kinase 8	Homo sapiens	57-60
20338993-5	2010	Chloramphenicol also activated c-Jun N-terminal kinases (JNK) and phosphatidylinositol 3-kinase (PI-3K)/Akt signaling, leading to c-Jun protein phosphorylation.	Chloramphenicol	0-15	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	66-95
20338993-5	2010	Chloramphenicol also activated c-Jun N-terminal kinases (JNK) and phosphatidylinositol 3-kinase (PI-3K)/Akt signaling, leading to c-Jun protein phosphorylation.	Chloramphenicol	0-15	AKT serine/threonine kinase 1	Homo sapiens	104-107
20338993-5	2010	Chloramphenicol also activated c-Jun N-terminal kinases (JNK) and phosphatidylinositol 3-kinase (PI-3K)/Akt signaling, leading to c-Jun protein phosphorylation.	Chloramphenicol	0-15	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-36
20338993-7	2010	Both the SP 600125 (JNK inhibitor) and LY 294002 (PI-3K/Akt inhibitor) can inhibit chloramphenicol-induced c-Jun phosphorylation, MMP-13 expression, and cell invasion.	Chloramphenicol	83-98	mitogen-activated protein kinase 8	Homo sapiens	20-23
20338993-7	2010	Both the SP 600125 (JNK inhibitor) and LY 294002 (PI-3K/Akt inhibitor) can inhibit chloramphenicol-induced c-Jun phosphorylation, MMP-13 expression, and cell invasion.	Chloramphenicol	83-98	AKT serine/threonine kinase 1	Homo sapiens	56-59
20338993-7	2010	Both the SP 600125 (JNK inhibitor) and LY 294002 (PI-3K/Akt inhibitor) can inhibit chloramphenicol-induced c-Jun phosphorylation, MMP-13 expression, and cell invasion.	Chloramphenicol	83-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-112
20338993-7	2010	Both the SP 600125 (JNK inhibitor) and LY 294002 (PI-3K/Akt inhibitor) can inhibit chloramphenicol-induced c-Jun phosphorylation, MMP-13 expression, and cell invasion.	Chloramphenicol	83-98	matrix metallopeptidase 13	Homo sapiens	130-136
20338993-8	2010	Overexpression of the dominant-negative JNK and PI-3K p85 subunit also negate chloramphenicol-induced responses.	Chloramphenicol	78-93	mitogen-activated protein kinase 8	Homo sapiens	40-43
19998329-5	2010	Cimetidine and chloramphenicol completely abrogated methemoglobin generation by dapsone, thus confirming a predominant contribution of CYP2C19.	Chloramphenicol	15-30	hemoglobin subunit gamma 2	Homo sapiens	52-65
20374640-7	2010	Resistance genes included dfr, TEM beta-lactamase, tet and cat, conferring resistance to trimethoprim, ampicillin, tetracycline and chloramphenicol, respectively.	Chloramphenicol	132-147	blaTEM	Escherichia coli	31-49
20008037-0	2010	Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol.	Chloramphenicol	89-104	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	24-30
20549950-14	2010	TMP-SMX resistance was two fold more in beta-lactamase producers compared with the non-producers, whereas chloramphenicol resistance revealed a significant increase in beta-lactamase producers (1% versus 44.5%).	Chloramphenicol	106-121	beta-lactamase TEM-1	Haemophilus influenzae	168-182
19728780-3	2009	The bla(TEM-52)-containing isolate showed a phenotype of multiresistance that included fluoroquinolones, tetracycline, trimethoprim-sulfamethoxazole, and chloramphenicol; sul1, sul3, and cmlA genes were detected in this isolate, in addition to two amino acid changes in GyrA (Ser83Leu + Asp87Asn) and one in ParC protein (Ser80Ile).	Chloramphenicol	154-169	TEM-52	Escherichia coli	8-14
18794387-2	2008	In agreement with in vitro evidence, these data suggest that chloramphenicol is a rather significant inhibitor of hepatic CYP3A4 and/or CYP2C19.	Chloramphenicol	61-76	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	122-128
19246767-4	2009	Replacement of the pg1401 gene in the chromosomal DNA with the chloramphenicol-resistance gene abolished indole production.	Chloramphenicol	63-78	PG_RS06165	Porphyromonas gingivalis W83	19-25
19743791-8	2009	Most of the isolates from UTI have high rates of resistance (&gt; 80%) to the commonly used antibiotics such as ampicillin, amoxicillin, chloramphenicol, gentamicin, streptomycin, and trimethoprim-sulphamethoxazole; and in isolates from SSI to amoxicillin and trimethoprim-sulphamethoxazole.	Chloramphenicol	137-152	alpha-1-microglobulin/bikunin precursor	Homo sapiens	26-29
18794387-2	2008	In agreement with in vitro evidence, these data suggest that chloramphenicol is a rather significant inhibitor of hepatic CYP3A4 and/or CYP2C19.	Chloramphenicol	61-76	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	136-143
18633946-1	2008	A competitive immunoassay using CE with an LIF detector was developed for the detection of chloramphenicol (CAP).	Chloramphenicol	91-106	LIF interleukin 6 family cytokine	Homo sapiens	43-46
18684218-4	2008	Enzymatic activities--superoxide dismutase, catalase and diaphorase enzymes--increased after chloramphenicol treatment, while the glutathione level decreased in neutrophils incubated with antibiotic.	Chloramphenicol	93-108	catalase	Homo sapiens	44-52
18684218-4	2008	Enzymatic activities--superoxide dismutase, catalase and diaphorase enzymes--increased after chloramphenicol treatment, while the glutathione level decreased in neutrophils incubated with antibiotic.	Chloramphenicol	93-108	dihydrolipoamide dehydrogenase	Homo sapiens	57-67
18559535-4	2008	By investigating the effects of chloramphenicol on the activation of mouse T cells stimulated with anti-CD3 antibody or staphylococcal enterotoxin B, we found that chloramphenicol induces the differentiation of activated T cells into lymphoblastic leukemia-like cells, characterized by large cell size, multiploid nuclei, and expression of CD7, a maker for immature T cells and T-cell lymphocytic leukemia, thus phenotypically indicating differentiation toward leukemogenesis.	Chloramphenicol	32-47	CD3 antigen, epsilon polypeptide	Mus musculus	104-107
18565457-5	2008	Penicillin-resistant and chloramphenicol-resistant bacteria are a considerable threat in resource-poor settings that go undetected if CSF and blood can not be cultured.	Chloramphenicol	25-40	colony stimulating factor 2	Homo sapiens	134-137
18559535-6	2008	Chloramphenicol inhibited the activation-induced cell death of mouse and human T-cell receptor-activated T cells by down-regulating the expression of Fas ligand.	Chloramphenicol	0-15	Fas ligand	Homo sapiens	150-160
18559535-4	2008	By investigating the effects of chloramphenicol on the activation of mouse T cells stimulated with anti-CD3 antibody or staphylococcal enterotoxin B, we found that chloramphenicol induces the differentiation of activated T cells into lymphoblastic leukemia-like cells, characterized by large cell size, multiploid nuclei, and expression of CD7, a maker for immature T cells and T-cell lymphocytic leukemia, thus phenotypically indicating differentiation toward leukemogenesis.	Chloramphenicol	164-179	CD3 antigen, epsilon polypeptide	Mus musculus	104-107
18559535-4	2008	By investigating the effects of chloramphenicol on the activation of mouse T cells stimulated with anti-CD3 antibody or staphylococcal enterotoxin B, we found that chloramphenicol induces the differentiation of activated T cells into lymphoblastic leukemia-like cells, characterized by large cell size, multiploid nuclei, and expression of CD7, a maker for immature T cells and T-cell lymphocytic leukemia, thus phenotypically indicating differentiation toward leukemogenesis.	Chloramphenicol	164-179	CD7 antigen	Mus musculus	340-343
18559535-5	2008	High expression of cyclin B1, but not p53, c-myc, and CDC25A, was detected in chloramphenicol-treated activated T cells, which may relate to abnormal cell differentiation.	Chloramphenicol	78-93	cyclin B1	Mus musculus	19-28
17692887-5	2008	The effect of temperature on the degradation rate of Chloramphenicol shows similar apparent activation energies for both TiO(2) P-25 and ZnO photocatalysts.	Chloramphenicol	53-68	tubulin polymerization promoting protein	Homo sapiens	128-132
18590157-6	2008	Aspiration through an AFA FPP-15 aerosol filter is a suitable device for air chloramphenicol sampling.	Chloramphenicol	77-92	AFA	Homo sapiens	22-25
17517865-6	2007	Signaling was abrogated if the F. tularensis LVS organisms were heat or formalin killed or treated with chloramphenicol, indicating that the TLR2 agonist activity is dependent on new bacterial protein synthesis.	Chloramphenicol	104-119	toll-like receptor 2	Mus musculus	141-145
17901903-3	2007	We demonstrate that differences in the amino acid sequence of the small domain and specific charged amino acids in the large domain of cytochrome f alter the physical properties of this protein but do not affect either the thermostability of the c-type heme, the apparent half-life of cytochrome f in the presence of the chloroplastic protein synthesis inhibitor chloramphenicol, or the capacity for photosynthetic intersystem electron transport, measured as e-/P700.	Chloramphenicol	363-378	cytochrome f	Chlamydomonas reinhardtii	135-147
17963129-6	2007	The activity of aldehyde dehydrogenase 2 was inhibited by disulfiram, chloramphenicol, and furazolidone, but not by metronidazole or quinacrine.	Chloramphenicol	70-85	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	16-40
17431428-6	2007	Moreover, we show that specific inhibition of mitochondrial translation with chloramphenicol inhibits the IFNalpha-induced degradation of mitochondrial mRNA by RNase L.	Chloramphenicol	77-92	interferon alpha 1	Homo sapiens	106-114
17431428-6	2007	Moreover, we show that specific inhibition of mitochondrial translation with chloramphenicol inhibits the IFNalpha-induced degradation of mitochondrial mRNA by RNase L.	Chloramphenicol	77-92	ribonuclease L	Homo sapiens	160-167
17536935-7	2007	Chloramphenicol resistance was due to the gene catA1 in all the chloramphenicol resistant isolates.	Chloramphenicol	0-15	hypothetical protein	Escherichia coli	47-52
17457038-0	2007	Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12.	Chloramphenicol	32-47	autophagy related 12	Homo sapiens	94-99
17457038-7	2007	We show here that chloramphenicol, which inhibits mitochondrial protein synthesis, induces ATG12, and that mtDNA deletions result in an increased burden of oxidatively damaged protein.	Chloramphenicol	18-33	autophagy related 12	Homo sapiens	91-96
17442666-7	2007	The PA2022 mutant and PA2022-PA3559 double mutant, but not the PA3559 mutant, are more susceptible to chloramphenicol, cefotaxime, and ampicillin.	Chloramphenicol	102-117	UDP-glucose 6-dehydrogenase	Pseudomonas aeruginosa PAO1	4-10
17442666-7	2007	The PA2022 mutant and PA2022-PA3559 double mutant, but not the PA3559 mutant, are more susceptible to chloramphenicol, cefotaxime, and ampicillin.	Chloramphenicol	102-117	UDP-glucose 6-dehydrogenase	Pseudomonas aeruginosa PAO1	22-28
17442666-7	2007	The PA2022 mutant and PA2022-PA3559 double mutant, but not the PA3559 mutant, are more susceptible to chloramphenicol, cefotaxime, and ampicillin.	Chloramphenicol	102-117	nucleotide sugar dehydrogenase	Pseudomonas aeruginosa PAO1	29-35
17536935-7	2007	Chloramphenicol resistance was due to the gene catA1 in all the chloramphenicol resistant isolates.	Chloramphenicol	64-79	hypothetical protein	Escherichia coli	47-52
17536935-8	2007	The strB, strA, and catA1 genes were transferable by conjugation and this points to the significance of conjugative resistance plasmids in the spread and persistence of streptomycin and chloramphenicol resistance in food animals in Kenya.	Chloramphenicol	186-201	aminoglycoside-3''-phosphotransferase	Escherichia coli	10-14
17536935-8	2007	The strB, strA, and catA1 genes were transferable by conjugation and this points to the significance of conjugative resistance plasmids in the spread and persistence of streptomycin and chloramphenicol resistance in food animals in Kenya.	Chloramphenicol	186-201	hypothetical protein	Escherichia coli	20-25
17180456-2	2007	In the presence of chloramphenicol (CAP), which freezes translating chloroplast ribosomes, a 1.5-kb tufA RNA becomes prominent.	Chloramphenicol	19-34	elongation factor Tu	Chlamydomonas reinhardtii	100-104
17251428-6	2007	CAT (chloramphenicol acetyltransferase) assays showed that CBF (CCAAT box binding factor, CCAAT/enhancer binding protein zeta) activated, but p53 repressed transcription of the hsp70 gene in granule cells.	Chloramphenicol	5-20	heat shock protein family A (Hsp70) member 4	Homo sapiens	177-182
17393096-6	2007	The expression of pT7-PL-RAP in the presence of chloramphenicol was higher than in the absence of chloramphenicol, and most of the inducible expressed RAP was soluble.	Chloramphenicol	48-63	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	25-28
17393096-6	2007	The expression of pT7-PL-RAP in the presence of chloramphenicol was higher than in the absence of chloramphenicol, and most of the inducible expressed RAP was soluble.	Chloramphenicol	98-113	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	25-28
16670108-10	2006	CONCLUSIONS: The results of this study showed that in the bovine pathogen P. trehalosi, floR-mediated resistance to chloramphenicol and florfenicol was associated with a plasmid, which also carried functionally active genes for resistance to sulphonamides (sul2) and chloramphenicol (catA3).	Chloramphenicol	116-131	floR	Bibersteinia trehalosi	88-92
17114320-5	2007	Further studies with a mexF deletion mutant demonstrated that the multidrug resistance pump encoded by mexF is required for resistance to antibiotics, including chloramphenicol and tetracycline.	Chloramphenicol	161-176	multidrug efflux RND transporter permease subunit	Shewanella oneidensis MR-1	23-27
17114320-5	2007	Further studies with a mexF deletion mutant demonstrated that the multidrug resistance pump encoded by mexF is required for resistance to antibiotics, including chloramphenicol and tetracycline.	Chloramphenicol	161-176	multidrug efflux RND transporter permease subunit	Shewanella oneidensis MR-1	103-107
16720568-2	2006	METHODS: PCR was used to assess the distribution of the major chloramphenicol and kanamycin resistance genes catA1, cmlA and floR, and aphA1, aphA2 and aadB in enterotoxigenic E. coli (ETEC), non-ETEC isolates from cases of diarrhoea and commensal E. coli from healthy pigs.	Chloramphenicol	62-77	hypothetical protein	Escherichia coli	109-114
16670108-10	2006	CONCLUSIONS: The results of this study showed that in the bovine pathogen P. trehalosi, floR-mediated resistance to chloramphenicol and florfenicol was associated with a plasmid, which also carried functionally active genes for resistance to sulphonamides (sul2) and chloramphenicol (catA3).	Chloramphenicol	267-282	floR	Bibersteinia trehalosi	88-92
16760518-8	2006	The floR gene was the main mechanism of resistance to chloramphenicol.	Chloramphenicol	54-69	florfenicol chloramphenicol resistance protein FloR	Salmonella enterica subsp. enterica serovar Typhimurium	4-8
16788067-5	2006	In addition, transcription antitermination activity was demonstrated for WCSP1 by using an E. coli strain that has a hairpin loop upstream of a chloramphenicol resistance gene.	Chloramphenicol	144-159	glycine-rich protein 2	Triticum aestivum	73-78
16261590-3	2006	Inhibition of mitochondrial activity by chloramphenicol abrogated the decrease in c-myc mRNA and protein levels occurring at the onset of terminal differentiation.	Chloramphenicol	40-55	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-87
16531478-6	2006	FSM resistance and other rif10-like phenotypes were also observed in wild-type Arabidopsis, tomato (Lycopersicon esculentum), and rice (Oryza sativa) seedlings grown in the presence of sublethal concentrations of chloramphenicol (an inhibitor of protein synthesis in plastids).	Chloramphenicol	213-228	polyribonucleotide nucleotidyltransferase	Arabidopsis thaliana	25-30
16261590-6	2006	Moreover, like chloramphenicol, c-myc overexpression strongly inhibited the myogenic influence of p43 overexpression.	Chloramphenicol	15-30	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	98-101
16261590-8	2006	Lastly, we found that chloramphenicol influence is negatively related to the frequency of post-mitotic myoblasts in the culture at the onset of treatment, and cell cycle analyses demonstrated that the frequency of myoblasts in G0-G1 phase at cell confluence is increased by p43 overexpression and decreased by chloramphenicol or c-myc overexpression.	Chloramphenicol	22-37	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	274-277
16261590-8	2006	Lastly, we found that chloramphenicol influence is negatively related to the frequency of post-mitotic myoblasts in the culture at the onset of treatment, and cell cycle analyses demonstrated that the frequency of myoblasts in G0-G1 phase at cell confluence is increased by p43 overexpression and decreased by chloramphenicol or c-myc overexpression.	Chloramphenicol	22-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	329-334
15927884-6	2005	In addition, we demonstrate that the amount of ribosome-associated Cbs1p is elevated in the presence of chloramphenicol, which is known to stall ribosomes on mRNAs.	Chloramphenicol	104-119	Cbs1p	Saccharomyces cerevisiae S288C	67-72
16139359-4	2006	A rop-containing derivative of pBAD24 (called pBAD322) having the copy number of pBR322 is reported together with derivatives of pBAD322 that encode resistance to chloramphenicol, kanamycin, tetracycline, spectinomycin/streptomycin, gentamycin, or trimethoprim in place of ampicillin.	Chloramphenicol	163-178	regulatory protein Rop	Escherichia coli	2-5
16457617-4	2006	We determined that chloramphenicol and clarithromycin were effective inhibitors of serum hPON1.	Chloramphenicol	19-34	paraoxonase 1	Homo sapiens	89-94
17073630-10	2006	To expand the structural diversity of synthetic courmarins for biological functions, attempts have also been made to attach a chloramphenicol side chain at C-3 position of courmarin.	Chloramphenicol	126-141	complement C3	Homo sapiens	156-159
16091044-1	2005	The gene product of cfr from Staphylococcus sciuri confers resistance to chloramphenicol, florfenicol and clindamycin in Staphylococcus spp.	Chloramphenicol	73-88	florfenicol/chloramphenicol resistance protein	Staphylococcus sciuri	20-23
16091044-5	2005	As chloramphenicol/florfenicol and clindamycin have partly overlapping drug binding sites on the ribosome, the most likely explanation is that Cfr modifies the RNA in the drug binding site.	Chloramphenicol	3-18	florfenicol/chloramphenicol resistance protein	Escherichia coli	143-146
16091044-9	2005	The results show that Cfr is an RNA methyltransferase that targets nucleotide A2503 and inhibits ribose methylation at nucleotide C2498, thereby causing resistance to chloramphenicol, florfenicol and clindamycin.	Chloramphenicol	167-182	florfenicol/chloramphenicol resistance protein	Escherichia coli	22-25
15905168-0	2005	Chloramphenicol-induced mitochondrial stress increases p21 expression and prevents cell apoptosis through a p21-dependent pathway.	Chloramphenicol	0-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	55-58
15905168-0	2005	Chloramphenicol-induced mitochondrial stress increases p21 expression and prevents cell apoptosis through a p21-dependent pathway.	Chloramphenicol	0-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	108-111
15905168-4	2005	Cellular levels of the p21(waf1/cip1) protein and p21(waf1/cip1) mRNA were increased through a p53-independent pathway, possibly because of the stabilization of p21(waf1/cip1) mRNA in chloramphenicol-treated cells.	Chloramphenicol	184-199	cyclin dependent kinase inhibitor 1A	Homo sapiens	23-36
15905168-4	2005	Cellular levels of the p21(waf1/cip1) protein and p21(waf1/cip1) mRNA were increased through a p53-independent pathway, possibly because of the stabilization of p21(waf1/cip1) mRNA in chloramphenicol-treated cells.	Chloramphenicol	184-199	cyclin dependent kinase inhibitor 1A	Homo sapiens	50-63
15905168-4	2005	Cellular levels of the p21(waf1/cip1) protein and p21(waf1/cip1) mRNA were increased through a p53-independent pathway, possibly because of the stabilization of p21(waf1/cip1) mRNA in chloramphenicol-treated cells.	Chloramphenicol	184-199	tumor protein p53	Homo sapiens	95-98
15905168-4	2005	Cellular levels of the p21(waf1/cip1) protein and p21(waf1/cip1) mRNA were increased through a p53-independent pathway, possibly because of the stabilization of p21(waf1/cip1) mRNA in chloramphenicol-treated cells.	Chloramphenicol	184-199	cyclin dependent kinase inhibitor 1A	Homo sapiens	50-63
15980376-3	2005	We also showed that FloR is a transporter specific for structurally associated phenicol drugs (chloramphenicol, florfenicol, thiamphenicol) which utilizes the proton motive force to energize an active efflux mechanism.	Chloramphenicol	95-110	FloR	Salmonella enterica	20-24
15855539-1	2005	The florfenicol/chloramphenicol resistance gene floR was found to be part of the novel 4,284-bp transposon TnfloR from Escherichia coli.	Chloramphenicol	16-31	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	48-52
15845488-4	2005	Analysis of host cells by flow cytometry using a fluorescent terminal deoxynucleotidyltransferase dUTP-biotin nick end labeling (TUNEL) assay revealed that 70% of THP-1 cells showed DNA fragmentation after 4 h of infection, increasing to greater than 90% by 5.5 h. Moreover, the results showed that gentamicin-killed or chloramphenicol-treated bacteria did not induce DNA fragmentation.	Chloramphenicol	320-335	GLI family zinc finger 2	Homo sapiens	163-168
15876223-3	2005	The presence of genes encoding chloramphenicol acetyltransferase (CAT) and tetracycline resistance (tet); tet(K), (L), (M), and (O) were determined by PCR in the 29 chloramphenicol and tetracycline resistant isolates.	Chloramphenicol	31-46	chloramphenicol acetyltransferase	Staphylococcus aureus	66-69
15814600-8	2005	In pCCK381, combined resistance to chloramphenicol and florfenicol was based on the presence of a floR gene that showed 97.2-99.7% identity to so far known floR genes.	Chloramphenicol	35-50	florfenicol-chloramphenicol exporter	Pasteurella multocida	98-102
15814600-8	2005	In pCCK381, combined resistance to chloramphenicol and florfenicol was based on the presence of a floR gene that showed 97.2-99.7% identity to so far known floR genes.	Chloramphenicol	35-50	florfenicol-chloramphenicol exporter	Pasteurella multocida	156-160
15814600-9	2005	CONCLUSIONS: The results of this study showed that a plasmid-borne floR gene was responsible for chloramphenicol and florfenicol resistance in the bovine respiratory tract pathogen P. multocida.	Chloramphenicol	97-112	florfenicol-chloramphenicol exporter	Pasteurella multocida	67-71
15838033-10	2005	Disruption of pmfR by homologous recombination with a chloramphenicol resistance cassette demonstrated that PmfR acts in vivo as a transcriptional activator.	Chloramphenicol	54-69	pmfR	Paenarthrobacter nicotinovorans	14-18
15838033-10	2005	Disruption of pmfR by homologous recombination with a chloramphenicol resistance cassette demonstrated that PmfR acts in vivo as a transcriptional activator.	Chloramphenicol	54-69	pmfR	Paenarthrobacter nicotinovorans	108-112
15668031-0	2005	The chloramphenicol resistance gene cmlA is disseminated on transferable plasmids that confer multiple-drug resistance in swine Escherichia coli.	Chloramphenicol	4-19	chloramphenicol resistance protein	Escherichia coli	36-40
15183689-5	2004	The recombinant P450arom NmA264R was expressed in Escherichia coli (350-400 nmol/L culture) primarily by coexpression with molecular chaperones GroES/GroEL while NmA264C was expressed (240 nmol/L culture) only in the presence of chloramphenicol.	Chloramphenicol	229-244	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	16-24
15331605-0	2004	High resolution studies of the Afa/Dr adhesin DraE and its interaction with chloramphenicol.	Chloramphenicol	76-91	AFA	Homo sapiens	31-34
15331605-4	2004	One such difference is disruption of the interaction between DraE and CD55 by chloramphenicol, whereas binding of AfaE-III to CD55 is unaffected.	Chloramphenicol	78-93	CD55 molecule (Cromer blood group)	Homo sapiens	70-74
15331605-7	2004	The crystal structure reveals the precise atomic basis for the sensitivity of DraE-CD55 binding to chloramphenicol and demonstrates that in contrast to other chloramphenicol-protein complexes, drug binding is mediated via recognition of the chlorine "tail" rather than via intercalation of the benzene rings into a hydrophobic pocket.	Chloramphenicol	99-114	CD55 molecule (Cromer blood group)	Homo sapiens	83-87
15331605-7	2004	The crystal structure reveals the precise atomic basis for the sensitivity of DraE-CD55 binding to chloramphenicol and demonstrates that in contrast to other chloramphenicol-protein complexes, drug binding is mediated via recognition of the chlorine "tail" rather than via intercalation of the benzene rings into a hydrophobic pocket.	Chloramphenicol	158-173	CD55 molecule (Cromer blood group)	Homo sapiens	83-87
15377639-0	2004	Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 (UGT2B21) and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation.	Chloramphenicol	132-147	UDP-glucuronosyltransferase 2B21	Cavia porcellus	38-70
15377639-0	2004	Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 (UGT2B21) and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation.	Chloramphenicol	132-147	UDP-glucuronosyltransferase 2B21	Cavia porcellus	72-79
15377639-0	2004	Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 (UGT2B21) and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation.	Chloramphenicol	132-147	UDP-glucuronosyltransferase 2B21	Cavia porcellus	114-121
15377639-2	2004	In this work, further evidence for a functional hetero-oligomer between UGT2B21 and UGT2B22 was provided by studies of the glucuronidation of chloramphenicol with dual expression in COS-7 cells.	Chloramphenicol	142-157	UDP-glucuronosyltransferase 2B21	Cavia porcellus	72-79
15377639-2	2004	In this work, further evidence for a functional hetero-oligomer between UGT2B21 and UGT2B22 was provided by studies of the glucuronidation of chloramphenicol with dual expression in COS-7 cells.	Chloramphenicol	142-157	UDP-glucuronosyltransferase 2B22	Cavia porcellus	84-91
15377639-3	2004	UGT2B21 expressed in COS cells was capable of glucuronidating the 3-hydroxyl group of morphine, 4-hydroxybiphenyl, borneol, testosterone, androsterone, and estriol, whereas it had some effect on chloramphenicol.	Chloramphenicol	195-210	UDP-glucuronosyltransferase 2B21	Cavia porcellus	0-7
15377639-5	2004	When UGT2B21 and UGT2B22 were expressed simultaneously, the chloramphenicol glucuronidation was enhanced to 4.5-fold, whereas the activities toward other substrates were little affected except that for the 6-hydroxyl group of morphine.	Chloramphenicol	60-75	UDP-glucuronosyltransferase 2B21	Cavia porcellus	5-12
15377639-5	2004	When UGT2B21 and UGT2B22 were expressed simultaneously, the chloramphenicol glucuronidation was enhanced to 4.5-fold, whereas the activities toward other substrates were little affected except that for the 6-hydroxyl group of morphine.	Chloramphenicol	60-75	UDP-glucuronosyltransferase 2B22	Cavia porcellus	17-24
15377639-7	2004	These results suggest that simultaneous expression of UGT2B21 and UGT2B22 enhances UGT2B21-catalyzed chloramphenicol glucuronidation.	Chloramphenicol	101-116	UDP-glucuronosyltransferase 2B21	Cavia porcellus	54-61
15377639-7	2004	These results suggest that simultaneous expression of UGT2B21 and UGT2B22 enhances UGT2B21-catalyzed chloramphenicol glucuronidation.	Chloramphenicol	101-116	UDP-glucuronosyltransferase 2B22	Cavia porcellus	66-73
15377639-7	2004	These results suggest that simultaneous expression of UGT2B21 and UGT2B22 enhances UGT2B21-catalyzed chloramphenicol glucuronidation.	Chloramphenicol	101-116	UDP-glucuronosyltransferase 2B21	Cavia porcellus	83-90
15377639-8	2004	Hetero-oligomer formation of UGT2B21 and UGT2B22 may act by fine-tuning the catalytic glucuronidation of chloramphenicol.	Chloramphenicol	105-120	UDP-glucuronosyltransferase 2B21	Cavia porcellus	29-36
15377639-8	2004	Hetero-oligomer formation of UGT2B21 and UGT2B22 may act by fine-tuning the catalytic glucuronidation of chloramphenicol.	Chloramphenicol	105-120	UDP-glucuronosyltransferase 2B22	Cavia porcellus	41-48
15130601-5	2004	It may be oxidized by SDH to release chloramphenicol (CAP), which may inhibit SDH by feed back mechanism.	Chloramphenicol	37-52	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	22-25
15130601-5	2004	It may be oxidized by SDH to release chloramphenicol (CAP), which may inhibit SDH by feed back mechanism.	Chloramphenicol	37-52	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	78-81
15130601-5	2004	It may be oxidized by SDH to release chloramphenicol (CAP), which may inhibit SDH by feed back mechanism.	Chloramphenicol	54-57	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	22-25
15130601-5	2004	It may be oxidized by SDH to release chloramphenicol (CAP), which may inhibit SDH by feed back mechanism.	Chloramphenicol	54-57	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	78-81
14699125-3	2004	In this study, we show that the plasma membrane protein Pdr15p displays limited drug transport capacity, mediating chloramphenicol and detergent tolerance.	Chloramphenicol	115-130	ATP-binding cassette multidrug transporter PDR15	Saccharomyces cerevisiae S288C	56-62
14576103-0	2003	Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes.	Chloramphenicol	0-15	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	66-73
14576103-0	2003	Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes.	Chloramphenicol	0-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	78-84
14576103-2	2003	Chloramphenicol had a potent inhibitory effect on CYP2C19-catalyzed S-mephytoin 4"-hydroxylation and CYP3A4-catalyzed midazolam 1-hydroxylation, with apparent 50% inhibitory concentrations (inhibitory constant [K(i)] values are shown in parentheses) of 32.0 (7.7) and 48.1 (10.6) microM, respectively.	Chloramphenicol	0-15	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	50-57
14576103-2	2003	Chloramphenicol had a potent inhibitory effect on CYP2C19-catalyzed S-mephytoin 4"-hydroxylation and CYP3A4-catalyzed midazolam 1-hydroxylation, with apparent 50% inhibitory concentrations (inhibitory constant [K(i)] values are shown in parentheses) of 32.0 (7.7) and 48.1 (10.6) microM, respectively.	Chloramphenicol	0-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	101-107
14614545-1	2003	Recently, an Escherichia coli CM2555 strain was described as sensitive to chloramphenicol when expressing the chloramphenicol resistance gene (cat) from a multicopy plasmid.	Chloramphenicol	74-89	chloramphenicol acetyltransferase	Escherichia coli	143-146
14576103-3	2003	Chloramphenicol also weakly inhibited CYP2D6, with an apparent 50% inhibitory concentration (K(i)) of 375.9 (75.8) microM.	Chloramphenicol	0-15	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	38-44
14614545-1	2003	Recently, an Escherichia coli CM2555 strain was described as sensitive to chloramphenicol when expressing the chloramphenicol resistance gene (cat) from a multicopy plasmid.	Chloramphenicol	110-125	chloramphenicol acetyltransferase	Escherichia coli	143-146
14576103-4	2003	The mechanism of the drug interaction reported between chloramphenicol and phenytoin, which results in the elevation of plasma phenytoin concentrations, is clinically assumed to result from the inhibition of CYP2C9 by chloramphenicol.	Chloramphenicol	55-70	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	208-214
14576103-4	2003	The mechanism of the drug interaction reported between chloramphenicol and phenytoin, which results in the elevation of plasma phenytoin concentrations, is clinically assumed to result from the inhibition of CYP2C9 by chloramphenicol.	Chloramphenicol	218-233	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	208-214
14576103-6	2003	In conclusion, inhibition of CYP2C19 and CYP3A4 is the probable mechanism by which chloramphenicol decreases the clearance of coadministered drugs, which manifests as a drug interaction with chloramphenicol.	Chloramphenicol	83-98	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	29-36
14576103-6	2003	In conclusion, inhibition of CYP2C19 and CYP3A4 is the probable mechanism by which chloramphenicol decreases the clearance of coadministered drugs, which manifests as a drug interaction with chloramphenicol.	Chloramphenicol	83-98	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47
14576103-6	2003	In conclusion, inhibition of CYP2C19 and CYP3A4 is the probable mechanism by which chloramphenicol decreases the clearance of coadministered drugs, which manifests as a drug interaction with chloramphenicol.	Chloramphenicol	191-206	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	29-36
14576103-6	2003	In conclusion, inhibition of CYP2C19 and CYP3A4 is the probable mechanism by which chloramphenicol decreases the clearance of coadministered drugs, which manifests as a drug interaction with chloramphenicol.	Chloramphenicol	191-206	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47
12363006-0	2002	Inactivation of the acrA gene is partially responsible for chloramphenicol sensitivity of Escherichia coli CM2555 strain expressing the chloramphenicol acetyltransferase gene.	Chloramphenicol	59-74	chloramphenicol acetyltransferase	Escherichia coli	136-169
12814968-4	2003	In wild-type mice, PCN treatment significantly increased UGT activities toward bilirubin, 1-naphthol, chloramphenicol, thyroxine, and triiodothyronine.	Chloramphenicol	102-117	solute carrier family 35 (UDP-galactose transporter), member A2	Mus musculus	57-60
12749881-2	2003	This oligomer and its all-phosphodiester analogue, 1707, were shown to: (1) bind to TAR at 37 degrees C with K(d)"s in the low nM concentration range; (2) inhibit Tat-TAR complex formation; and (3) inhibit expression of a chloramphenicol reporter gene under control of the HIV LTR in HeLa HL3T1 cells in culture.	Chloramphenicol	222-237	RNA binding motif protein 8A	Homo sapiens	84-87
12604529-11	2003	Two representative chloramphenicol-resistant strains showed expression of an outer membrane protein slightly larger than OprM.	Chloramphenicol	19-34	outer membrane protein OprM	Pseudomonas aeruginosa PAO1	121-125
12606012-4	2003	Although the N-terminal replacement alone was not sufficient for the expression, human P450arom was successfully expressed up to the level of 240nmol/l culture by the combination of the N-terminal replacement and the induction of cold stress response by 1 microg/ml chloramphenicol.	Chloramphenicol	266-281	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	87-95
12450802-7	2002	The genes in parentheses were associated with resistance to kanamycin (aphA1-Ia), chloramphenicol (catA1), tetracycline [tet(A)], and ampicillin (bla(TEM-1)).	Chloramphenicol	82-97	hypothetical protein	Escherichia coli	99-104
12557277-3	2003	Disruption of PDH1 in a cgcdr1::ura3 strain increased susceptibility to rhodamine 6G, cycloheximide and chloramphenicol, and also increased rhodamine 6G accumulation, all properties of pdr5 null mutants.	Chloramphenicol	104-119	putative 2-methylcitrate dehydratase	Saccharomyces cerevisiae S288C	14-18
12557277-4	2003	Overexpression of PDH1 in S. cerevisiae complemented the pdr5 mutation by reversing susceptibility to rhodamine 6G, chloramphenicol and cycloheximide, as well as by decreasing rhodamine 6G intracellular concentration.	Chloramphenicol	116-131	putative 2-methylcitrate dehydratase	Saccharomyces cerevisiae S288C	18-22
12557277-4	2003	Overexpression of PDH1 in S. cerevisiae complemented the pdr5 mutation by reversing susceptibility to rhodamine 6G, chloramphenicol and cycloheximide, as well as by decreasing rhodamine 6G intracellular concentration.	Chloramphenicol	116-131	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	57-61
12542469-4	2003	Inhibition of TNF-alpha secretion occurred also when J774 cells were infected with F. tularensis LVS in the presence of chloramphenicol, but not when they were infected with a mutant of F. tularensis LVS defective in expression of a 23 kDa protein that is upregulated during intracellular infection.	Chloramphenicol	120-135	tumor necrosis factor	Mus musculus	14-23
12641819-4	2002	In previous studies, we developed a mouse model of the reversible reticulocytopenia/anaemia using CAP succinate (CAPS); attempts to induce AA in the mouse with CAPS were unsuccessful; in the rat, CAPS induced only minimal haemotoxicity.	Chloramphenicol	98-101	Ca2+-dependent secretion activator	Mus musculus	113-117
12363006-2	2002	It was proposed that this sensitivity is due to decreased levels of acetyl coenzyme A (Acetyl CoA) in cat-expressing CM2555 cells in the presence of chloramphenicol.	Chloramphenicol	149-164	chloramphenicol acetyltransferase	Escherichia coli	102-105
12363006-3	2002	CAT catalyzes transfer of the acetyl moiety from Acetyl CoA to a chloramphenicol molecule.	Chloramphenicol	65-80	chloramphenicol acetyltransferase	Escherichia coli	0-3
12363006-7	2002	Here, we found that overexpression of the acrEF genes, encoding a transmembrane pump, or the acrE gene alone, results in restoration of chloramphenicol-resistance of cat-expressing CM2555 strain.	Chloramphenicol	136-151	chloramphenicol acetyltransferase	Escherichia coli	166-169
12363006-9	2002	Although introduction of the deltaacrAB allele into CM732, a parental strain of CM2555, and into some other commonly used E. coli strains led to their chloramphenicol sensitivity in the presence of CAT, the same genetic manipulation did not result in such a phenotype in other genetic backgrounds, including "wild-type" E. coli MG1655.	Chloramphenicol	151-166	chloramphenicol acetyltransferase	Escherichia coli	198-201
12363006-10	2002	These results suggest that the acrA dysfunction is one of more mutations responsible for chloramphenicol sensitivity of cat-expressing CM2555 strain.	Chloramphenicol	89-104	chloramphenicol acetyltransferase	Escherichia coli	120-123
12363006-1	2002	An Escherichia coli CM2555 strain, sensitive to chloramphenicol when expressing the cat gene and producing active chloramphenicol acetyltransferase (CAT), was described recently.	Chloramphenicol	48-63	chloramphenicol acetyltransferase	Escherichia coli	84-87
12363006-1	2002	An Escherichia coli CM2555 strain, sensitive to chloramphenicol when expressing the cat gene and producing active chloramphenicol acetyltransferase (CAT), was described recently.	Chloramphenicol	48-63	chloramphenicol acetyltransferase	Escherichia coli	114-147
12363006-1	2002	An Escherichia coli CM2555 strain, sensitive to chloramphenicol when expressing the cat gene and producing active chloramphenicol acetyltransferase (CAT), was described recently.	Chloramphenicol	48-63	chloramphenicol acetyltransferase	Escherichia coli	149-152
12099697-5	2002	Transient transfection of astrocytes with APP gene promoter (-2832 bp) chloramphenicol acetyltransferase (CAT) reporter constructs led to increased reporter activity upon TGF-beta stimulation.	Chloramphenicol	71-86	transforming growth factor alpha	Homo sapiens	171-179
12011428-6	2002	Bovine aortic endothelial cells were treated with chloramphenicol, which resulted in a decreased ratio of mitochondrial complex IV to cytochrome c and increased oxidant production in the cell.	Chloramphenicol	50-65	LOC104968582	Bos taurus	134-146
11996969-4	2002	In-frame insertions of &gt;or=25 repeats in the chloramphenicol acetyltransferase (CAT) gene of pBR325 resulted in a chloramphenicol-sensitive (Cm(s)) phenotype.	Chloramphenicol	48-63	chloramphenicol acetyltransferase	Escherichia coli	83-86
12073095-6	2002	Surprisingly, the PDR2-2-mediated hyperresistance to chloramphenicol, anisomycin, and cycloheximide requires the function of the UBP6 gene and at least one other gene product.	Chloramphenicol	53-68	Yrr1p	Saccharomyces cerevisiae S288C	18-22
12073095-6	2002	Surprisingly, the PDR2-2-mediated hyperresistance to chloramphenicol, anisomycin, and cycloheximide requires the function of the UBP6 gene and at least one other gene product.	Chloramphenicol	53-68	ubiquitin-specific protease UBP6	Saccharomyces cerevisiae S288C	129-133
11709351-0	2001	Chloramphenicol-sensitive Escherichia coli strain expressing the chloramphenicol acetyltransferase (cat) gene.	Chloramphenicol	0-15	chloramphenicol acetyltransferase	Escherichia coli	65-98
11709351-0	2001	Chloramphenicol-sensitive Escherichia coli strain expressing the chloramphenicol acetyltransferase (cat) gene.	Chloramphenicol	0-15	chloramphenicol acetyltransferase	Escherichia coli	100-103
11709351-1	2001	An Escherichia coli strain (strain CM2555) bearing the chloramphenicol acetyltransferase (cat) gene was found to be sensitive to chloramphenicol.	Chloramphenicol	55-70	chloramphenicol acetyltransferase	Escherichia coli	90-93
11709351-3	2001	Our results suggest that decreased levels of acetyl coenzyme A in cat-expressing CM2555 cells in the presence of chloramphenicol may cause the bacterium to be sensitive to this antibiotic.	Chloramphenicol	113-128	chloramphenicol acetyltransferase	Escherichia coli	66-69
11785449-8	2001	One hundred per cent association was found between results of disc diffusion, MIC and CAT production amongst strains resistant to chloramphenicol.	Chloramphenicol	130-145	chloramphenicol acetyltransferase II	Haemophilus influenzae	86-89
11532908-8	2001	We hypothesized that phosphorylation of mitochondrial EF-Tu would inhibit mitochondrial protein translation and attempted to reproduce the effect with inhibition of mitochondrial protein synthesis by chloramphenicol.	Chloramphenicol	200-215	elongation factor 1-alpha 1	Oryctolagus cuniculus	54-59
11451703-0	2001	Nonenzymatic chloramphenicol resistance mediated by IncC plasmid R55 is encoded by a floR gene variant.	Chloramphenicol	13-28	florfenicol/chloramphenicol resistance protein FloR	Escherichia coli	85-89
10866313-7	2000	Perturbation of mitochondrial function mediated accumulation of wild-type p53 protein, since Bcl-2 overexpression, bongkrekic acid, or inhibition of mitochondrial protein synthesis with chloramphenicol strongly reduced TK/GCV-induced accumulation of wild-type p53 protein.	Chloramphenicol	186-201	tumor protein p53	Homo sapiens	74-77
11173480-2	2001	The enzyme inactivates the antibiotic chloramphenicol and is a member of the xenobiotic acetyltransferase family.	Chloramphenicol	38-53	acetyltransferase	Escherichia coli	88-105
11306037-3	2001	Chloramphenicol which also elutes the enzyme from the affinity column, shows a discriminatory effect by inhibiting the ALDH1 oxidation of benzaldehyde and activating that of propionaldehyde while showing no effect when assayed with hexanal or cyclohexane-carboxaldehyde.	Chloramphenicol	0-15	aldehyde dehydrogenase 1 family member A1	Homo sapiens	119-124
11191208-4	2000	After in vitro mutagenesis of the PDR3 gene six single amino acid substitutions were identified and resulted in resistance to cycloheximide, sulfomethuron methyl, 4-nitroquinoline oxide, fluconazole, mucidin, chloramphenicol and oligomycin.	Chloramphenicol	209-224	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	34-38
11144420-5	2000	The overall frequency of drug resistance traits among the 1,749 MRSA strains was high (over 70% and up to and over 90% of the strains) to ciprofloxacin, erythromycin, clindamycin, gentamicin, and tetracycline, and was somewhat less frequent to sulfamethoxazole-trimethoprim (45%), chloramphenicol (30%), and rifampin (38%).	Chloramphenicol	281-296	solute carrier family 9 member A6	Homo sapiens	64-68
10858345-3	2000	Isolate EP2 was also more resistant to chloramphenicol, tetracyclines, cefuroxime, and organic solvents.	Chloramphenicol	39-54	prostaglandin E receptor 2	Homo sapiens	8-11
10858345-6	2000	In isolate EP2 complemented with wild-type marR, susceptibility to chloramphenicol was restored completely, whereas susceptibility to CIP was restored only incompletely.	Chloramphenicol	67-82	prostaglandin E receptor 2	Homo sapiens	11-14
10990266-1	2000	The role of two chaperone proteins, DnaK and the cooperating factor DnaJ, in Escherichia coli antibiotic susceptibility to three antibiotics (a beta-lactam, chloramphenicol, tetracycline) has been studied.	Chloramphenicol	157-172	DnaJ	Escherichia coli	68-72
10952608-3	2000	The amino acid sequence of the Cfr protein revealed no homology to known acetyltransferases or efflux proteins involved in chloramphenicol and/or florfenicol resistance or to other proteins whose functions are known.	Chloramphenicol	123-138	florfenicol/chloramphenicol resistance protein	Staphylococcus sciuri	31-34
10770778-2	2000	Evidence is provided that Salmonella enterica serovar Agona strains isolated from poultry harbor a similar gene cluster including the newly described floR gene, conferring cross-resistance to chloramphenicol and florfenicol.	Chloramphenicol	192-207	FloR	Salmonella enterica	150-154
10923860-9	2000	Chloramphenicol (a specific CYP2B11 inhibitor) and diethyldithiocarbamate (a non-specific CYP2 inhibitor) inhibited propofol hydroxylation in all microsomes.	Chloramphenicol	0-15	cytochrome P450 2B11	Canis lupus familiaris	28-35
10816522-6	2000	Furthermore, inhibition of bacterial protein synthesis with chloramphenicol prevented up-regulation of IL-6 and bFGF in infected cells.	Chloramphenicol	60-75	interleukin 6	Homo sapiens	103-107
10816522-6	2000	Furthermore, inhibition of bacterial protein synthesis with chloramphenicol prevented up-regulation of IL-6 and bFGF in infected cells.	Chloramphenicol	60-75	fibroblast growth factor 2	Homo sapiens	112-116
10699571-3	2000	4-MeSO(2)-2,2",4",5,5",6-hexaCB (4-MeSO(2)-CB149) increased the activity of UDP-GT toward chloramphenicol (UGT2B1) but not toward 4-nitrophenol (UGT1A6) and 4-methylumbelliferone (UGT1A6).	Chloramphenicol	90-105	UDP glucuronosyltransferase family 2 member B17	Rattus norvegicus	107-113
10729207-1	2000	Expression of human cytochrome P450 (P450) 2B6 in Escherichia coli was achieved following supplementation of the expression medium with chloramphenicol.	Chloramphenicol	136-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	20-46
10760244-5	2000	Analysis of chlL transcript distribution on polysome profiles and rates of protein turnover in chloramphenicol-treated cells suggested that CHLL formation is most probably blocked at translation initiation or elongation.	Chloramphenicol	95-110	photochlorophyllide reductase subunit L	Chlamydomonas reinhardtii	12-16
10760244-5	2000	Analysis of chlL transcript distribution on polysome profiles and rates of protein turnover in chloramphenicol-treated cells suggested that CHLL formation is most probably blocked at translation initiation or elongation.	Chloramphenicol	95-110	photochlorophyllide reductase subunit L	Chlamydomonas reinhardtii	140-144
10699571-3	2000	4-MeSO(2)-2,2",4",5,5",6-hexaCB (4-MeSO(2)-CB149) increased the activity of UDP-GT toward chloramphenicol (UGT2B1) but not toward 4-nitrophenol (UGT1A6) and 4-methylumbelliferone (UGT1A6).	Chloramphenicol	90-105	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	145-151
10699571-3	2000	4-MeSO(2)-2,2",4",5,5",6-hexaCB (4-MeSO(2)-CB149) increased the activity of UDP-GT toward chloramphenicol (UGT2B1) but not toward 4-nitrophenol (UGT1A6) and 4-methylumbelliferone (UGT1A6).	Chloramphenicol	90-105	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	180-186
10644737-7	2000	Whereas myogenin mRNA and protein levels were down-regulated by chloramphenicol treatment, they were up-regulated by p43 overexpression, in a positive relationship with the expression level of the transgene.	Chloramphenicol	64-79	myogenin	Gallus gallus	8-16
10666642-1	2000	Chloramphenicol acetyltransferase (CAT) is responsible for bacterial resistance to chloramphenicol.	Chloramphenicol	83-98	chloramphenicol acetyltransferase	Escherichia coli	0-33
10666642-1	2000	Chloramphenicol acetyltransferase (CAT) is responsible for bacterial resistance to chloramphenicol.	Chloramphenicol	83-98	chloramphenicol acetyltransferase	Escherichia coli	35-38
10430173-0	1999	Chloramphenicol-induced mitochondrial dysfunction is associated with decreased transferrin receptor expression and ferritin synthesis in K562 cells and is unrelated to IRE-IRP interactions.	Chloramphenicol	0-15	transferrin	Homo sapiens	79-90
10508860-6	1999	Chloramphenicol acetyltransferase assays in F9 cells showed that PS1 suppresses transactivation by c-Jun/c-Jun but not by c-Jun/c-Fos heterodimers, consistent with the reported function of QM/Jif-1.	Chloramphenicol	0-15	presenilin 1	Homo sapiens	65-68
10508860-6	1999	Chloramphenicol acetyltransferase assays in F9 cells showed that PS1 suppresses transactivation by c-Jun/c-Jun but not by c-Jun/c-Fos heterodimers, consistent with the reported function of QM/Jif-1.	Chloramphenicol	0-15	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-104
10508860-6	1999	Chloramphenicol acetyltransferase assays in F9 cells showed that PS1 suppresses transactivation by c-Jun/c-Jun but not by c-Jun/c-Fos heterodimers, consistent with the reported function of QM/Jif-1.	Chloramphenicol	0-15	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-110
10508860-6	1999	Chloramphenicol acetyltransferase assays in F9 cells showed that PS1 suppresses transactivation by c-Jun/c-Jun but not by c-Jun/c-Fos heterodimers, consistent with the reported function of QM/Jif-1.	Chloramphenicol	0-15	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-110
10523871-22	1999	We conclude that the administration of CAPS to CD-1 mice induced haematological changes showing close parallels with the chloramphenicol-induced reversible anaemia seen in man.	Chloramphenicol	121-136	CD1 antigen complex	Mus musculus	47-51
10600163-8	1999	A 870-bp fragment of ALA-S 5"-flanking region is able to provide cAMP and phenobarbital stimulation to chloramphenicol O-acetyltranferase fusion vectors in transiently transfected HepG2 cells.	Chloramphenicol	103-118	5'-aminolevulinate synthase 1	Homo sapiens	21-26
10542282-3	1999	The 5" end of the ccsB gene, which is involved in the maturation process and resembles the ccs1 gene from Chlamydomonas reinhardtii, was replaced by a chloramphenicol resistance cartridge in the cyanobacterium Synechocystis sp.	Chloramphenicol	151-166	uncharacterized protein	Chlamydomonas reinhardtii	91-95
10591537-5	1999	Deletion fusion constructs containing regions of the Aldh3a1 gene 5" flanking sequence, ligated to chloramphenicol experiments suggested that the 5" flanking region of the gene contains a strong promoter, at least four functional AHREs appear to act cooperatively in causing dioxin-mediated upregulation, and a putative negative regulatory element (NRE) controls basal gene expression independent of dioxin inducibility.	Chloramphenicol	99-114	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	53-60
10430173-4	1999	We hypothesized that chloramphenicol-induced mitochondrial impairment alters the synthesis of ferritin and the transferrin receptor.	Chloramphenicol	21-36	transferrin	Homo sapiens	111-122
10430173-5	1999	After treating K562 erythroleukemia cells with a therapeutic dose of chloramphenicol (10 microg/ml) for 4 days, there was a marked decrease in cell surface transferrin receptor expression and de novo ferritin synthesis associated with significant decreases in cytochrome c oxidase activity, ATP levels, respiratory activity, and cell growth.	Chloramphenicol	69-84	transferrin	Homo sapiens	156-167
10430173-10	1999	A disturbance in iron homeostasis due to alterations in the transferrin receptor and ferritin may explain the hypochromic-microcytic anemia and the accumulation of nonferritin iron in the mitochondria in some individuals after chloramphenicol therapy.	Chloramphenicol	227-242	transferrin	Homo sapiens	60-71
10501313-10	1999	The production of chloramphenicol acetyltransferase, an enzyme capable of catalyzing the conversion of chloramphenicol to its nonfunctional 1-acetoxy, 3-acetoxy, and 1,3-diacetoxy derivatives, leads to chloramphenicol resistance in S pneumoniae.	Chloramphenicol	103-118	CAT	Staphylococcus aureus	18-51
10493593-6	1999	This method is based on our observation that cells expressing fusions of an insoluble protein to chloramphenicol acetyltransferase (CAT) exhibit decreased resistance to chloramphenicol compared to fusions with soluble proteins.	Chloramphenicol	97-112	chloramphenicol acetyltransferase	Escherichia coli	132-135
10493593-7	1999	We found that a soluble mutant of an insoluble protein fused to CAT could be selected by plating on high levels of chloramphenicol.	Chloramphenicol	115-130	chloramphenicol acetyltransferase	Escherichia coli	64-67
10588052-4	1999	The pdr3-9 allele conferred resistance of transformed cells to cycloheximide, chloramphenicol, mucidin and oligomycin both in the absence and in the presence of a chromosomal copy of the PDR3 gene.	Chloramphenicol	78-93	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	4-8
10037801-1	1999	The replication initiator protein RepD encoded by the Staphylococcus chloramphenicol resistance plasmid pC221 stimulates the helicase activity of the Bacillus stearothermophilus PcrA DNA helicase in vitro.	Chloramphenicol	69-84	DNA helicase	Escherichia coli	183-195
10037734-4	1999	A 90-nucleotide sequence in the APP gene 5"-untranslated region (5"-UTR) conferred translational regulation by IL-1alpha and IL-1beta to a chloramphenicol acetyltransferase (CAT) reporter gene.	Chloramphenicol	139-154	interleukin 1 alpha	Homo sapiens	111-120
10037734-4	1999	A 90-nucleotide sequence in the APP gene 5"-untranslated region (5"-UTR) conferred translational regulation by IL-1alpha and IL-1beta to a chloramphenicol acetyltransferase (CAT) reporter gene.	Chloramphenicol	139-154	interleukin 1 alpha	Homo sapiens	125-133
10445748-13	1999	UDPGT activity toward chloramphenicol was induced 1.8-fold, while no change in UDPGT activity toward 4-nitrophenol was seen.	Chloramphenicol	22-37	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-5
10359656-5	1999	Quercetin also caused an increase in the transcription of a chloramphenicol reporter vector containing the CYP1A1 promoter.	Chloramphenicol	60-75	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	107-113
10427468-9	1999	Serious adverse events associated with chloramphenicol toxicity in the neonate have highlighted the importance of developmental changes in UGT activity.	Chloramphenicol	39-54	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	139-142
10049283-1	1999	The spirochete Borrelia burgdorferi was unexpectedly found to be as susceptible to diacetyl chloramphenicol, the product of the enzyme chloramphenicol acetyltransferase, as it was to chloramphenicol itself.	Chloramphenicol	92-107	chloramphenicol acetyltransferase	Escherichia coli	135-168
10049283-5	1999	In the presence of 10% rabbit serum, a strain of E. coli bearing the chloramphenicol acetyltransferase (cat) gene had a fourfold-lower resistance to chloramphenicol than in the absence of serum.	Chloramphenicol	69-84	chloramphenicol acetyltransferase	Escherichia coli	104-107
10049283-8	1999	These studies indicate that esterases of serum can convert diacetyl chloramphenicol back to an active antibiotic, and thus, in vitro findings may not accurately reflect the level of chloramphenicol resistance by cat-bearing bacteria in vivo.	Chloramphenicol	68-83	chloramphenicol acetyltransferase	Escherichia coli	18-21
9398267-7	1997	In parental DU24 cells, MEK2 mRNA content decreased after inhibition of mtDNA transcription by EtdBr and inhibition of translation on mitoribosomes by chloramphenicol (CAM).	Chloramphenicol	151-166	mitogen-activated protein kinase kinase 2	Gallus gallus	24-28
9931456-6	1998	We also report much improved expression of intact recombinant HMG1 in Escherichia coli by the use of chloramphenicol rather than ampicillin selection and conditions that limit cell growth.	Chloramphenicol	101-116	high mobility group box 1	Gallus gallus	62-66
10347866-2	1998	It carries the chloramphenicol resistance gene (cat) from Tn9, which is not transcribed in either host by lack of a promoter.	Chloramphenicol	15-30	chloramphenicol acetyltransferase	Escherichia coli	48-51
10347866-5	1998	These mutant plasmids expressed chloramphenicol acetyltransferase (CAT), conferring on B. subtilis resistance to high chloramphenicol concentrations.	Chloramphenicol	32-47	chloramphenicol acetyltransferase	Escherichia coli	67-70
9930670-2	1998	Such truncated CAT polypeptides quantitatively aggregate into cytoplasmic inclusion bodies, which results in absence of a chloramphenicol-resistant phenotype for the producing host.	Chloramphenicol	122-137	chloramphenicol acetyltransferase	Escherichia coli	15-18
9930670-4	1998	Random mutagenesis of inactive CAT followed by direct phenotypic selection for revertants with restored chloramphenicol resistance was used to isolate second-site suppressors of inactive truncation mutants of CAT.	Chloramphenicol	104-119	chloramphenicol acetyltransferase	Escherichia coli	31-34
9930670-4	1998	Random mutagenesis of inactive CAT followed by direct phenotypic selection for revertants with restored chloramphenicol resistance was used to isolate second-site suppressors of inactive truncation mutants of CAT.	Chloramphenicol	104-119	chloramphenicol acetyltransferase	Escherichia coli	209-212
9744970-11	1998	The resistance to chloramphenicol is due to the presence of the catP gene on a truncated transposon that has lost mobility because of internal deletions, and the transformation of genetic material between strains of N. meningitidis probably played an important part in the dissemination of the gene.	Chloramphenicol	18-33	catP	Clostridium perfringens	64-68
9696748-2	1998	The role of the outer membrane protein, TraN, during conjugative transfer was examined by introduction of a chloramphenicol resistance cassette into the traN gene on an F plasmid derivative, pOX38, to produce pOX38N1::CAT.	Chloramphenicol	108-123	tRNA-Ala (anticodon TGC) 7-1	Homo sapiens	40-44
9760750-5	1998	The results showed that CAT mRNAs devoid of both leader sequence nucleotides and the two downstream boxes in the CAT gene remained active in vivo and produced CAT protein in sufficient amounts for survival of the transformed cells at chloramphenicol concentrations up to 20-30 micrograms/ml.	Chloramphenicol	234-249	chloramphenicol acetyltransferase	Escherichia coli	24-27
9760750-5	1998	The results showed that CAT mRNAs devoid of both leader sequence nucleotides and the two downstream boxes in the CAT gene remained active in vivo and produced CAT protein in sufficient amounts for survival of the transformed cells at chloramphenicol concentrations up to 20-30 micrograms/ml.	Chloramphenicol	234-249	chloramphenicol acetyltransferase	Escherichia coli	113-116
9760750-5	1998	The results showed that CAT mRNAs devoid of both leader sequence nucleotides and the two downstream boxes in the CAT gene remained active in vivo and produced CAT protein in sufficient amounts for survival of the transformed cells at chloramphenicol concentrations up to 20-30 micrograms/ml.	Chloramphenicol	234-249	chloramphenicol acetyltransferase	Escherichia coli	113-116
9453158-7	1998	cycloheximide, chloramphenicol, fluconazole and o-phenanthroline, to which CDR1 confers resistance, could also prevent efflux and enhance accumulation to some extent.	Chloramphenicol	15-30	cerebellar degeneration related protein 1	Homo sapiens	75-79
9398267-7	1997	In parental DU24 cells, MEK2 mRNA content decreased after inhibition of mtDNA transcription by EtdBr and inhibition of translation on mitoribosomes by chloramphenicol (CAM).	Chloramphenicol	168-171	mitogen-activated protein kinase kinase 2	Gallus gallus	24-28
9398267-9	1997	The MEK2 protein content is decreased in DUS3 rho0 cells and in parental DU24 rho+ cells treated with EtdBr and CAM for 6 days, while that of MEK1, a closely related kinase, remained unchanged.	Chloramphenicol	112-115	mitogen-activated protein kinase kinase 2	Gallus gallus	4-8
9202456-3	1997	Following plasmid integration the desired dcrA deletion mutant (D. vulgaris F100) was obtained in media containing sucrose and chloramphenicol.	Chloramphenicol	127-142	dcrA	Desulfovibrio vulgaris str. Hildenborough	42-46
9305959-12	1997	In addition, 2B1 and the expressed 2B2 variants showed differential susceptibility to the mechanism-based inactivators chloramphenicol and N-(2-p-nitrophenethyl)chlorofluoroacetamide.	Chloramphenicol	119-134	UDP glucuronosyltransferase family 2 member B17	Rattus norvegicus	13-16
9413996-8	1997	OrfA also inhibited the intermolecular transposition of mini-IS3 with the chloramphenicol-resistance gene flanked by IRs to a reduced frequency, and OrfB together with OrfA inhibited it almost completely.	Chloramphenicol	74-89	chromodomain helicase DNA binding protein 7	Homo sapiens	61-64
9284114-5	1997	In an additional experiment, we observed that chloramphenicol clearly inhibited P-LPS-stimulated expression of the CD14, IL-1beta, and IL-6 genes in calvarial cells.	Chloramphenicol	46-61	CD14 antigen	Mus musculus	115-119
9284114-5	1997	In an additional experiment, we observed that chloramphenicol clearly inhibited P-LPS-stimulated expression of the CD14, IL-1beta, and IL-6 genes in calvarial cells.	Chloramphenicol	46-61	interleukin 1 beta	Mus musculus	121-129
9284114-5	1997	In an additional experiment, we observed that chloramphenicol clearly inhibited P-LPS-stimulated expression of the CD14, IL-1beta, and IL-6 genes in calvarial cells.	Chloramphenicol	46-61	interleukin 6	Mus musculus	135-139
9284114-6	1997	These results suggest that chloramphenicol might be a useful antibiotic as an anti-inflammatory agent against P-LPS-stimulated periodontal destruction occurring via CD14 in periodontal disease.	Chloramphenicol	27-42	CD14 antigen	Mus musculus	165-169
9199447-6	1997	Invasion stimulation did not appear to involve de novo synthesis of a bacterial protein, as FCS and fibrinogen stimulated invasion in the presence of chloramphenicol.	Chloramphenicol	150-165	fibrinogen beta chain	Homo sapiens	100-110
8940064-4	1996	By point mutation analysis using chloramphenicol acetyltransferase plasmids in 293E1 cells, which express significant levels of flt-1 mRNA, we found that an Ets motif, E4, at -54 to -51 and a cAMP response element (CRE) at -83 to -76 are involved in the transcriptional regulation of this gene.	Chloramphenicol	33-48	fms related receptor tyrosine kinase 1	Homo sapiens	128-133
9130514-1	1997	The involvement of cytochrome-P450-dependent metabolism of small-molecular-weight compounds as a prerequisite for an optimal lymphocyte response to those compounds is discussed on the basis of studies with compound such as p-phenylenediamine, sulfamethoxazole, chloramphenicol and fragrances.	Chloramphenicol	261-276	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	19-34
9223231-7	1997	Production of superoxide radicals measured by the cytochrome c reduction assay was lowered by danofloxacin, penicillin and chloramphenicol.	Chloramphenicol	123-138	LOC104968582	Bos taurus	50-62
8951046-5	1996	A chloramphenicol-resistant, trc promoter-based plasmid has been constructed that allows coexpression of human calmodulin (CaM).	Chloramphenicol	2-17	calmodulin 1	Homo sapiens	111-121
8951046-5	1996	A chloramphenicol-resistant, trc promoter-based plasmid has been constructed that allows coexpression of human calmodulin (CaM).	Chloramphenicol	2-17	calmodulin 1	Homo sapiens	123-126
9029056-3	1997	The present study was designed to compare the reactivity and relative glucuronidation efficiencies of opioid agonists, antagonists, and partial agonists with two rat UGT isoforms; UGT1.1, which is generally considered the "bilirubin UGT," and UGT2B1, which has previously been shown to catalyze the glucuronidation of testosterone, chloramphenicol, and (-)-morphine.	Chloramphenicol	332-347	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	180-186
8937842-7	1996	The prevalence of beta-lactamase-positive isolates of M. catarrhalis increased from 92.1% in 1992 to 93.8% in 1993 and to 96.5% in 1994; however, isolates of this species were highly susceptible to amoxicillin-clavulanic acid, the cephalosporins, the macrolides, the fluoroquinolones, chloramphenicol, doxycycline, and trimethoprim-sulfamethoxazole.	Chloramphenicol	285-300	beta-lactamase TEM-1	Haemophilus influenzae	18-32
8710862-1	1996	Here we show that protein synthesis inhibitors chloramphenicol and erythromycin, which bind to domain V of 23S rRNA of E. coli, can inhibit reactivation of denatured pig muscle lactate dehydrogenase and fungal glucose-6-phosphate dehydrogenase by 23S rRNA completely.	Chloramphenicol	47-62	glucose-6-phosphate dehydrogenase	Sus scrofa	210-243
8954883-0	1996	Molecular characterization of a plasmid-borne (pTC82) chloramphenicol resistance determinant (cat-TC) from Lactobacillus reuteri G4.	Chloramphenicol	54-69	chloramphenicol acetyltransferase	Staphylococcus aureus	94-97
8561493-7	1996	The substrate specificity of UGTDOG-PB is similar to that of stably expressed UGT2B1 which is considered a phenobarbital-inducible morphine UGT in the rat except that UGTDOG-PB is capable of glucuronidating 4-nitrophenol but not chloramphenicol.	Chloramphenicol	229-244	UDP glucuronosyltransferase family 2 member B17	Rattus norvegicus	78-84
16535314-7	1996	Chloramphenicol blocked the reduction of As(V) to As(III) in nitrate-respiring sediments, suggesting that nitrate and arsenate were reduced by separate enzyme systems.	Chloramphenicol	0-15	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
8609408-9	1996	The proteic nature of the factor(s) was demonstrated by its heat and protease sensitiveness, and this could explain why U937-derived macrophages did release TNF-alpha when infected with chloramphenicol-treated brucellae.	Chloramphenicol	186-201	tumor necrosis factor	Homo sapiens	157-166
8685919-5	1996	Allopurinol, a xanthine oxidase (EC 1.2.3.2) inhibitor, partly inhibited the changes induced by chloramphenicol, as described above.	Chloramphenicol	96-111	xanthine dehydrogenase	Mus musculus	15-31
8685919-7	1996	Furthermore, the results obtained with allopurinol may indicate that enhanced levels of lipid peroxidation observed in chloramphenicol-treated animals are partly due to enhanced rate of the degradation of purine nucleotides catalyzed by xanthine oxidase.	Chloramphenicol	119-134	xanthine dehydrogenase	Mus musculus	237-253
8662692-4	1996	In transient transfection experiments, a stromelysin-1 promoter construct with 6A at the polymorphic site was found to express less of the chloramphenicol acetyltransferase reporter gene than a construct containing 5A.	Chloramphenicol	139-154	matrix metallopeptidase 3	Homo sapiens	41-54
8561493-7	1996	The substrate specificity of UGTDOG-PB is similar to that of stably expressed UGT2B1 which is considered a phenobarbital-inducible morphine UGT in the rat except that UGTDOG-PB is capable of glucuronidating 4-nitrophenol but not chloramphenicol.	Chloramphenicol	229-244	UDP-glucuronosyltransferase 1-6	Canis lupus familiaris	29-32
7574023-8	1995	Inhibitions obtained with chemicals or drugs glucuronidated by either UGT1 or UGT2 families (1-naphtol, 4-hydroxybiphenyl, carvacrol, n-propylgallate, ketoprofen, chloramphenicol, acetylsalicylic acid) indicated that at least two UGT isoforms are involved in propofol glucuronidation.	Chloramphenicol	163-178	UDP-glucose glycoprotein glucosyltransferase 2	Homo sapiens	78-82
8991079-4	1996	The gpt mutants can be positively detected as colonies arising on plates containing chloramphenicol and 6-thioguanine.	Chloramphenicol	84-99	glutamic pyruvic transaminase, soluble	Mus musculus	4-7
7663402-0	1995	1H and 13C NMR study of the molecular interaction mechanism between chloramphenicol and human serum albumin.	Chloramphenicol	68-83	albumin	Homo sapiens	94-107
7549530-1	1995	Determination of chloramphenicol (CAP) residues in egg by gas chromatography/high-resolution mass spectrometry (GC/HRMS) with negative chemical ionization and gas chromatography with electron capture detection (GC-ECD) is described.	Chloramphenicol	17-32	bromodomain containing 4	Homo sapiens	34-37
7670183-1	1995	We have examined the effects of dietary level of protein (5% or 30% in casein) on enzyme activities and mRNA levels of two xenobiotic-inducible UDPglucuronosyltransferase (UDPGT) enzymes, such as chloramphenicol-UDPGT (CP-UDPGT) and 4-nitrophenol-UDPGT (4NP-UDPGT), in the livers of rats treated or not treated with polychlorinated biphenyls (PCB).	Chloramphenicol	196-211	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	172-177
7670183-1	1995	We have examined the effects of dietary level of protein (5% or 30% in casein) on enzyme activities and mRNA levels of two xenobiotic-inducible UDPglucuronosyltransferase (UDPGT) enzymes, such as chloramphenicol-UDPGT (CP-UDPGT) and 4-nitrophenol-UDPGT (4NP-UDPGT), in the livers of rats treated or not treated with polychlorinated biphenyls (PCB).	Chloramphenicol	196-211	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	212-217
7670183-1	1995	We have examined the effects of dietary level of protein (5% or 30% in casein) on enzyme activities and mRNA levels of two xenobiotic-inducible UDPglucuronosyltransferase (UDPGT) enzymes, such as chloramphenicol-UDPGT (CP-UDPGT) and 4-nitrophenol-UDPGT (4NP-UDPGT), in the livers of rats treated or not treated with polychlorinated biphenyls (PCB).	Chloramphenicol	196-211	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	212-217
7670183-1	1995	We have examined the effects of dietary level of protein (5% or 30% in casein) on enzyme activities and mRNA levels of two xenobiotic-inducible UDPglucuronosyltransferase (UDPGT) enzymes, such as chloramphenicol-UDPGT (CP-UDPGT) and 4-nitrophenol-UDPGT (4NP-UDPGT), in the livers of rats treated or not treated with polychlorinated biphenyls (PCB).	Chloramphenicol	196-211	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	212-217
7670183-1	1995	We have examined the effects of dietary level of protein (5% or 30% in casein) on enzyme activities and mRNA levels of two xenobiotic-inducible UDPglucuronosyltransferase (UDPGT) enzymes, such as chloramphenicol-UDPGT (CP-UDPGT) and 4-nitrophenol-UDPGT (4NP-UDPGT), in the livers of rats treated or not treated with polychlorinated biphenyls (PCB).	Chloramphenicol	196-211	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	212-217
7787182-8	1995	Disruption of the cyanobacterial gdhA gene with a chloramphenicol resistance cassette yielded a mutant strain totally lacking NADP-GDH activity, demonstrating that this gene is not essential to Synechocystis 6803 under our laboratory conditions.	Chloramphenicol	50-65	glutamate dehydrogenase	Escherichia coli	33-37
7673750-7	1995	Among penicillin-resistant strains (PRP), co-resistance to trimethoprim, chloramphenicol and tetracycline was common.	Chloramphenicol	73-88	prion protein	Homo sapiens	36-39
7614555-2	1995	Transformation by CDR1 of a PDR5-disrupted host hypersensitive to cycloheximide and chloramphenicol resulted in resistance to cycloheximide, chloramphenicol and other drugs, such as the antifungal miconazole, with collateral hypersensitivity to oligomycin, nystatin and 2,4 dinitrophenol.	Chloramphenicol	84-99	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	28-32
7614555-2	1995	Transformation by CDR1 of a PDR5-disrupted host hypersensitive to cycloheximide and chloramphenicol resulted in resistance to cycloheximide, chloramphenicol and other drugs, such as the antifungal miconazole, with collateral hypersensitivity to oligomycin, nystatin and 2,4 dinitrophenol.	Chloramphenicol	141-156	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	28-32
7663402-3	1995	A schematic model of the complex-formation between serum albumin and chloramphenicol was proposed.	Chloramphenicol	69-84	albumin	Homo sapiens	51-64
7605135-0	1995	[The interaction of serum albumin and chloramphenicol].	Chloramphenicol	38-53	albumin	Homo sapiens	20-33
7630887-1	1995	The deletion of nine residues from the C-terminus of the bacterial chloramphenicol acetyltransferase (CAT) results in deposition of the mutant protein in cytoplasmic inclusion bodies and loss of chloramphenicol resistance in Escherichia coli.	Chloramphenicol	67-82	chloramphenicol acetyltransferase	Escherichia coli	102-105
7695156-8	1995	Significant (P &lt; 0.05) effects of chloramphenicol pretreatment included increased t1/2(beta) (by 209%), and decreased ClB (by 45%), and prolonged recovery indices (by 768 to 946%).	Chloramphenicol	37-52	interleukin 1 receptor like 1	Homo sapiens	85-95
8852339-2	1995	Transformation by CDR 1 of a PDR 5 disrupted host hypersensitive to cycloheximide and chloramphenicol resulted in resistance to these as well as other unrelated drugs.	Chloramphenicol	86-101	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	29-34
7647146-0	1995	Metabolism of chloramphenicol by glutathione S-transferase in human fetal and neonatal liver.	Chloramphenicol	14-29	glutathione S-transferase kappa 1	Homo sapiens	33-58
7752900-5	1995	Disruption of ORF1 with a chloramphenicol-resistance cassette (CAT) rendered the H. pylori mutants more susceptible to cupric ion than their parental strains, whereas there is no significant alteration of susceptibility to Ni2+, Cd2d+ and Hg2+ between the mutants and the parental strains.	Chloramphenicol	26-41	hypothetical protein	Helicobacter pylori	14-18
7932191-0	1994	Selective suppression of rat hepatic cytochrome P450 2C11 by chloramphenicol.	Chloramphenicol	61-76	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	37-57
7971966-3	1994	Coexpression of UR in COS-1 cells inhibited the stimulation of chloramphenicol acetyltransferase (CAT) reporter gene expression by hRXR alpha and human retinoic acid receptor alpha in the presence of all-trans-retinoic acid when DR-4 (but not DR-5) was present upstream of the promoter of a CAT reporter gene (DR-4-CAT).	Chloramphenicol	63-78	retinoid X receptor alpha	Homo sapiens	131-141
7840595-0	1994	Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux.	Chloramphenicol	96-111	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	69-73
7840595-2	1994	Loss of function mutations in PDR5 result in chloramphenicol hypersensitivity.	Chloramphenicol	45-60	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	30-34
7840595-3	1994	A pdr5::Tn5 loss of function mutant exhibits a markedly impaired efflux of chloramphenicol compared with that of an isogenic PDR5 (wild-type) control.	Chloramphenicol	75-90	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	2-6
7828346-10	1994	VDR cDNA was sequenced and transfected into VDR-deficient CV-1 cells for further analysis of functional response to 1,25(OH)2D3 following cotransfection with a chloramphenicol acetyltransferase (CAT) reporter plasmid.	Chloramphenicol	160-175	vitamin D receptor	Homo sapiens	0-3
8175715-4	1994	We demonstrated that the chimeric chloramphenicol acetyltransferase reporter constructs (the -103 to +1 sequence of the mouse lactoferrin gene) containing the mitogen-response unit of the lactoferrin gene were stimulated by cAMP, forskolin, 12-O-tetradecanoylphorbol-13-acetate, and epidermal growth factor/recombinant transforming growth factor-alpha (EGF/TGF-alpha) in a time- and dose-dependent manner.	Chloramphenicol	34-49	lactotransferrin	Mus musculus	126-137
8175715-4	1994	We demonstrated that the chimeric chloramphenicol acetyltransferase reporter constructs (the -103 to +1 sequence of the mouse lactoferrin gene) containing the mitogen-response unit of the lactoferrin gene were stimulated by cAMP, forskolin, 12-O-tetradecanoylphorbol-13-acetate, and epidermal growth factor/recombinant transforming growth factor-alpha (EGF/TGF-alpha) in a time- and dose-dependent manner.	Chloramphenicol	34-49	lactotransferrin	Mus musculus	188-199
8175715-4	1994	We demonstrated that the chimeric chloramphenicol acetyltransferase reporter constructs (the -103 to +1 sequence of the mouse lactoferrin gene) containing the mitogen-response unit of the lactoferrin gene were stimulated by cAMP, forskolin, 12-O-tetradecanoylphorbol-13-acetate, and epidermal growth factor/recombinant transforming growth factor-alpha (EGF/TGF-alpha) in a time- and dose-dependent manner.	Chloramphenicol	34-49	transforming growth factor alpha	Mus musculus	319-351
8175715-4	1994	We demonstrated that the chimeric chloramphenicol acetyltransferase reporter constructs (the -103 to +1 sequence of the mouse lactoferrin gene) containing the mitogen-response unit of the lactoferrin gene were stimulated by cAMP, forskolin, 12-O-tetradecanoylphorbol-13-acetate, and epidermal growth factor/recombinant transforming growth factor-alpha (EGF/TGF-alpha) in a time- and dose-dependent manner.	Chloramphenicol	34-49	epidermal growth factor	Mus musculus	353-356
8175715-4	1994	We demonstrated that the chimeric chloramphenicol acetyltransferase reporter constructs (the -103 to +1 sequence of the mouse lactoferrin gene) containing the mitogen-response unit of the lactoferrin gene were stimulated by cAMP, forskolin, 12-O-tetradecanoylphorbol-13-acetate, and epidermal growth factor/recombinant transforming growth factor-alpha (EGF/TGF-alpha) in a time- and dose-dependent manner.	Chloramphenicol	34-49	transforming growth factor alpha	Mus musculus	357-366