PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18350176-6	2008	(ii) INO3 is sufficiently stable to explain the kinetics of the recombination reaction between IO and NO2, and the reaction between I2 and NO3 to produce I + INO3 is almost certainly the major source of iodine oxides at night.	Nitrogen Dioxide	102-105	NBL1, DAN family BMP antagonist	Homo sapiens	6-9
18350185-9	2008	CH3C(O)C(O)O2 radicals oxidise NO2, forming NO3, CH3CO and CO2.	Nitrogen Dioxide	31-34	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
17914444-2	2008	The presence of inducible NO synthase protein in a number of inflammatory dermatoses, coupled with the induction of an intense cutaneous inflammatory infiltrate following topical application of the NO donor-acidified nitrite (NO2(-)), has set the paradigm of NO being an inflammatory mediator in human skin.	Nitrogen Dioxide	226-229	nitric oxide synthase 2	Homo sapiens	16-37
18075107-5	2007	The higher reaction rate in the NO3- system was attributed to the photolysis of NO3-, which resulted in the formation of NO2- for reduction of Cr(VI).	Nitrogen Dioxide	121-124	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
17975203-12	2008	A single injection of ONO-1301MS resulted in sustained activity for 3 weeks, and attenuated pulmonary hypertension, partly through its antiproliferative effect on vascular smooth muscle cells via inhibition of ERK phosphorylation.	Nitrogen Dioxide	22-25	Eph receptor B1	Rattus norvegicus	210-213
18089306-6	2007	Our results showed a time-dependent increase in iNOS expression, which was also confirmed by increased plasma formation of NO2-/NO3-.	Nitrogen Dioxide	123-126	nitric oxide synthase 2	Rattus norvegicus	48-52
18997379-4	2008	On the basis of this fundamental result, the total microchannel length required for the reaction of 2,3-diaminonaphthalene (DAN) and NO2- at a flow rate of 2 microL min(-1) was calculated, and the obtained value ( approximately 100 mm) showed very good agreement with our previous microchip research.	Nitrogen Dioxide	133-136	CD59 molecule (CD59 blood group)	Homo sapiens	165-171
18236232-9	2008	NO2 exposure increased goblet cells, eosinophils, and the levels of IL-6, while it decreased the levels of IL-10.	Nitrogen Dioxide	0-3	interleukin 6	Mus musculus	68-72
18236232-9	2008	NO2 exposure increased goblet cells, eosinophils, and the levels of IL-6, while it decreased the levels of IL-10.	Nitrogen Dioxide	0-3	interleukin 10	Mus musculus	107-112
18236232-11	2008	Instead, NO2 exposure attenuated the smoke-induced increases in levels of TNF-alpha, KC, and MCP-1.	Nitrogen Dioxide	9-12	tumor necrosis factor	Mus musculus	74-83
18236232-11	2008	Instead, NO2 exposure attenuated the smoke-induced increases in levels of TNF-alpha, KC, and MCP-1.	Nitrogen Dioxide	9-12	chemokine (C-C motif) ligand 2	Mus musculus	93-98
19462574-0	2007	Temperature dependence of the NO3 absorption cross-section above 298 K and determination of the equilibrium constant for NO3 + NO2 <--> N2O5 at atmospherically relevant conditions.	Nitrogen Dioxide	127-130	NBL1, DAN family BMP antagonist	Homo sapiens	121-124
18075107-5	2007	The higher reaction rate in the NO3- system was attributed to the photolysis of NO3-, which resulted in the formation of NO2- for reduction of Cr(VI).	Nitrogen Dioxide	121-124	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
17785804-4	2007	Following challenge with aerosolized OVA alone, mice previously exposed via inhalation to NO2 and OVA developed eosinophilic inflammation and mucus cell metaplasia in the lungs, as well as OVA-specific IgE and IgG1, and Th2-type cytokine responses.	Nitrogen Dioxide	90-93	LOC105243590	Mus musculus	210-214
17929845-4	2007	Among the three nitrogen oxides gases, NO2 substantially modifies the electrolyte via hydrolysis leading to the formation of NO3- and its adsorption on the BDD electrode surface.	Nitrogen Dioxide	39-42	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
17600531-3	2007	In the present study, we report on the reactivity of metNGB (ferric-NGB), which accumulates in vivo as a result of the reaction of oxyNGB (oxygenated NGB) with NO, towards NO2- and H2O2.	Nitrogen Dioxide	172-175	neuroglobin	Homo sapiens	56-59
17600531-3	2007	In the present study, we report on the reactivity of metNGB (ferric-NGB), which accumulates in vivo as a result of the reaction of oxyNGB (oxygenated NGB) with NO, towards NO2- and H2O2.	Nitrogen Dioxide	172-175	neuroglobin	Homo sapiens	68-71
18047090-4	2007	Interestingly, the Si-O linkage increased with increasing the concentration of catalyst AgNO3, implying that while Ag(0) species catalyze the Si-Si dehydrocoupling, Ag(I) species catalyze the Si-O dehydrocoupling along with the simultaneous oxidation of NO3 ion to NO2.	Nitrogen Dioxide	265-268	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
18047090-6	2007	The Si-Si/Si-O dehydrocoupling of 1 with AgNO3 even at dry nitrogen atmosphere is occurred, supporting that the oxidation of NO3- ion to NO2 is only the possible oxygen source, but not from the adventitious moisture in air.	Nitrogen Dioxide	137-140	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
17914782-2	2007	Laser photolysis (355 nm) of NO2 was used to produce O atoms, followed by O atom reactions with CS2, NO2, and HCNO, and infrared detection of OCS product from the O + CS2 reaction.	Nitrogen Dioxide	29-32	chorionic somatomammotropin hormone 2	Homo sapiens	96-99
17914782-2	2007	Laser photolysis (355 nm) of NO2 was used to produce O atoms, followed by O atom reactions with CS2, NO2, and HCNO, and infrared detection of OCS product from the O + CS2 reaction.	Nitrogen Dioxide	29-32	chorionic somatomammotropin hormone 2	Homo sapiens	167-170
17785804-4	2007	Following challenge with aerosolized OVA alone, mice previously exposed via inhalation to NO2 and OVA developed eosinophilic inflammation and mucus cell metaplasia in the lungs, as well as OVA-specific IgE and IgG1, and Th2-type cytokine responses.	Nitrogen Dioxide	90-93	heart and neural crest derivatives expressed 2	Mus musculus	220-223
17827864-8	2007	In a two-pollutant model including SPM and nitrogen dioxide (NO(2)) concentrations, increased serum CRP concentrations were also associated with SPM (OR =1.94, 95% CI: 1.08-3.50), but no such association was found with NO(2) (OR =0.62, 95% CI: 0.26-1.48).	Nitrogen Dioxide	43-59	C-reactive protein	Homo sapiens	100-103
17676847-1	2007	Photolysis of aqueous NO3(-) with lambda > or = 195 nm is known to induce the formation of NO2(-) and O2 as the only stable products.	Nitrogen Dioxide	94-97	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
17601801-6	2007	Impaired neovascularization in ecSOD(-/-) mice is associated with enhanced O2- production, TUNEL-positive apoptotic cells and decreased levels of NO2-/NO3- and cGMP in ischemic tissues as compared with wild-type mice, and it is rescued by infusion of the SOD mimetic tempol.	Nitrogen Dioxide	146-149	superoxide dismutase 3, extracellular	Mus musculus	31-36
17601801-9	2007	NO2-/NO3- and cGMP levels are decreased in ecSOD(-/-) BM.	Nitrogen Dioxide	0-3	superoxide dismutase 3, extracellular	Mus musculus	43-48
17676847-3	2007	This is, in part, due to photoisomerization of NO3(-) to ONOO(-) at lambda < 280 nm, followed by the formation of *OH and *NO2 through the decomposition of ONOOH (pKa = 6.5-6.8).	Nitrogen Dioxide	125-129	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
17317744-7	2007	The conductance has an anion-permeability sequence: NO3- approximately I- > NO2- > Br- > Cl- > SO4(2-) approximately HCO3- approximately gluconate- approximately aspartate- approximately cyclamate-.	Nitrogen Dioxide	79-82	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
17571880-3	2007	A second, and sometimes third, oxidation peak was also observed when the anodic limit was extended, and these were provisionally assigned to the oxidation of nitrogen dioxide (NO2) and nitrate (NO3-), respectively.	Nitrogen Dioxide	158-174	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
17571880-3	2007	A second, and sometimes third, oxidation peak was also observed when the anodic limit was extended, and these were provisionally assigned to the oxidation of nitrogen dioxide (NO2) and nitrate (NO3-), respectively.	Nitrogen Dioxide	176-179	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
17891979-6	2007	During day time, high concentrations of PAN and PPN occurred with high concentrations of NO2 when NO concentrations are fairly low.	Nitrogen Dioxide	89-92	adenosine deaminase 2	Homo sapiens	40-43
17891979-6	2007	During day time, high concentrations of PAN and PPN occurred with high concentrations of NO2 when NO concentrations are fairly low.	Nitrogen Dioxide	89-92	porcupine O-acyltransferase	Homo sapiens	48-51
17530864-13	2007	To account for reported observations of intracellular tyrosine nitration late in the life cycles of macrophages, we propose a novel mechanism wherein iNOS-generated NO2- is used by COX-2 to produce NO2* as a terminal microbicidal oxidant and nitrating agent.	Nitrogen Dioxide	165-168	nitric oxide synthase 2, inducible	Mus musculus	150-154
17530864-13	2007	To account for reported observations of intracellular tyrosine nitration late in the life cycles of macrophages, we propose a novel mechanism wherein iNOS-generated NO2- is used by COX-2 to produce NO2* as a terminal microbicidal oxidant and nitrating agent.	Nitrogen Dioxide	165-168	cytochrome c oxidase II, mitochondrial	Mus musculus	181-186
17530864-13	2007	To account for reported observations of intracellular tyrosine nitration late in the life cycles of macrophages, we propose a novel mechanism wherein iNOS-generated NO2- is used by COX-2 to produce NO2* as a terminal microbicidal oxidant and nitrating agent.	Nitrogen Dioxide	198-201	nitric oxide synthase 2, inducible	Mus musculus	150-154
17530864-13	2007	To account for reported observations of intracellular tyrosine nitration late in the life cycles of macrophages, we propose a novel mechanism wherein iNOS-generated NO2- is used by COX-2 to produce NO2* as a terminal microbicidal oxidant and nitrating agent.	Nitrogen Dioxide	198-201	cytochrome c oxidase II, mitochondrial	Mus musculus	181-186
17395009-6	2007	On the other hand, glutathione, known to react with both peroxynitrite and nitrogen dioxide, totally protected MnSOD from inactivation and nitration on addition of authentic peroxynitrite but, notably, it was only partially inhibitory in the presence of the more biologically relevant J*NO and JO(2)(*-).	Nitrogen Dioxide	75-91	superoxide dismutase 2	Homo sapiens	111-116
17395009-9	2007	Our results help to rationalize MnSOD tyrosine nitration observed in inflammatory conditions in vivo in the presence of low molecular weight scavengers such as glutathione that otherwise would completely consume nitrogen dioxide and prevent nitration reactions.	Nitrogen Dioxide	212-228	superoxide dismutase 2	Homo sapiens	32-37
16982182-8	2007	ONO markedly inhibited iNOS protein expression and nitrotyrosine production in lung homogenates.	Nitrogen Dioxide	0-3	nitric oxide synthase 2, inducible	Mus musculus	23-27
17592201-8	2007	However, the distribution of MMP-2 and MMP-12 was limited to the luminal side of lesions in the Chol + ONO group.	Nitrogen Dioxide	103-106	72 kDa type IV collagenase	Oryctolagus cuniculus	29-34
17142267-6	2007	We suggest that the CFTR pore has at least two anion binding sites at which Au(CN)2(-) and Pt(NO2)4(2-) block Cl- permeation.	Nitrogen Dioxide	94-97	CF transmembrane conductance regulator	Homo sapiens	20-24
17388277-1	2007	The interaction of NO3 free radical and N2O5 with laboratory flame soot was investigated in a Knudsen flow reactor at T = 298 K equipped with beam-sampling mass spectrometry and in situ REMPI detection of NO2 and NO.	Nitrogen Dioxide	205-208	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
17388277-4	2007	The major loss of NO3 is adsorption on gray and black soot at yields of 65 and 59%, respectively, and the main gas-phase reaction product is N2O5 owing to heterogeneous recombination of NO3 with NO2 and NO according to NO3 + {C} --> NO + products.	Nitrogen Dioxide	195-198	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
17388277-4	2007	The major loss of NO3 is adsorption on gray and black soot at yields of 65 and 59%, respectively, and the main gas-phase reaction product is N2O5 owing to heterogeneous recombination of NO3 with NO2 and NO according to NO3 + {C} --> NO + products.	Nitrogen Dioxide	195-198	NBL1, DAN family BMP antagonist	Homo sapiens	186-189
17388277-4	2007	The major loss of NO3 is adsorption on gray and black soot at yields of 65 and 59%, respectively, and the main gas-phase reaction product is N2O5 owing to heterogeneous recombination of NO3 with NO2 and NO according to NO3 + {C} --> NO + products.	Nitrogen Dioxide	195-198	NBL1, DAN family BMP antagonist	Homo sapiens	186-189
17364963-1	2007	Production of nitrogen dioxide by the activity of myeloperoxidase (MPO) in the presence of nitrite is now considered a key step in the pathophysiology of low-density lipoprotein (LDL) oxidation.	Nitrogen Dioxide	14-30	myeloperoxidase	Homo sapiens	50-65
17364963-1	2007	Production of nitrogen dioxide by the activity of myeloperoxidase (MPO) in the presence of nitrite is now considered a key step in the pathophysiology of low-density lipoprotein (LDL) oxidation.	Nitrogen Dioxide	14-30	myeloperoxidase	Homo sapiens	67-70
17169865-0	2007	Effects of nitrogen dioxide on the expression of intercellular adhesion molecule-1, neutrophil adhesion, and cytotoxicity: studies in human bronchial epithelial cells.	Nitrogen Dioxide	11-27	intercellular adhesion molecule 1	Homo sapiens	49-82
17169865-2	2007	We have recently reported that early changes in NO2-exposed human bronchial epithelial cells are causally linked to increased generation of proinflammatory mediators, such as nitric oxide/nitrite and cytokines like interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-8.	Nitrogen Dioxide	48-51	tumor necrosis factor	Homo sapiens	239-272
17169865-2	2007	We have recently reported that early changes in NO2-exposed human bronchial epithelial cells are causally linked to increased generation of proinflammatory mediators, such as nitric oxide/nitrite and cytokines like interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-8.	Nitrogen Dioxide	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	277-281
17169865-6	2007	Interestingly, an increased expression of HO-1, a redox-sensitive stress protein, was observed in NO2-exposed NHBE cells at 24 h. Since neutrophils (PMNs) play an active role in acute lung inflammation and resultant oxidative injury, we also investigated changes in human PMN-NHBE cell interactions.	Nitrogen Dioxide	98-101	heme oxygenase 1	Homo sapiens	42-46
17181358-1	2006	Quantum chemistry calculations reveal that it is both thermodynamically and kinetically feasible for NO2 to be oxidized by RDX (1,3,5-trinitrohexahydro-s-triazine) or its initial decomposition products.	Nitrogen Dioxide	101-104	radixin	Homo sapiens	123-126
17365587-7	2007	In single-pollutant models, the strongest associations were observed at lag 3 for a 10-microg/m3 increase of TSP (2.7% increase in ER, 95% CI 0.7-4.6) and PM10 (3.0% increase, 95% CI 0.4-5.7), and at lag 4 for a 10-microg/m3 increase of NO2 (11.0% increase in ER, 95% CI 3.6-18.8).	Nitrogen Dioxide	237-240	lymphocyte activating 3	Homo sapiens	72-77
17256540-6	2006	Subtraction of the resulting background signal provides NO2 measurements with a limit of detection of 150 ppt/10 s (SIN = 3).	Nitrogen Dioxide	56-59	SIN3 transcription regulator family member A	Homo sapiens	116-123
17149846-10	2006	In this respect, the competition between NO2 and O2 is considered: the rate ratios are such to indicate that the NO3 and HO initiated pathways are the major source of nitroarenes.	Nitrogen Dioxide	41-44	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
17128987-1	2006	We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release.	Nitrogen Dioxide	82-98	Rac family small GTPase 1	Homo sapiens	160-164
17128987-1	2006	We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release.	Nitrogen Dioxide	82-98	cell division cycle 42	Homo sapiens	166-171
17128987-1	2006	We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release.	Nitrogen Dioxide	82-98	ras homolog family member A	Homo sapiens	177-181
17029369-11	2006	The other three complexes show similar behavior to 3-H at 77 K, but the lower-energy emission bands are progressively red-shifted in the order H < OMe < NO2 < NEt2 (e.g., for 3-NEt2, lambda(max)(em) = 658 nm; tau = 26 micros).	Nitrogen Dioxide	159-162	tetraspanin 12	Homo sapiens	168-172
17034156-10	2006	CID of [VONO3(L)2]+, generated from spray solutions created by mixing VOSO4 and Ba(NO3)2 (and precipitation of BaSO4), caused elimination of NO2 to produce [VO2(L)2]+.	Nitrogen Dioxide	141-144	NBL1, DAN family BMP antagonist	Homo sapiens	10-13
16647868-7	2006	We also show that NO2* radicals, generated by a myeloperoxidase/H2O2/nitrite system, also degrade DMPO/HO*.	Nitrogen Dioxide	18-22	myeloperoxidase	Homo sapiens	48-63
16961380-5	2006	Kinetic and UV-vis spectroscopic data show that Cbl(NO2-) is generated during this reaction.	Nitrogen Dioxide	52-55	Cbl proto-oncogene	Homo sapiens	48-51
16905358-7	2006	The electrophysiological response to HCO3- and NO2- provides evidence that NAR1.2 is involved in both HCO3- and NO2- transport.	Nitrogen Dioxide	47-50	uncharacterized protein	Chlamydomonas reinhardtii	75-81
16905358-7	2006	The electrophysiological response to HCO3- and NO2- provides evidence that NAR1.2 is involved in both HCO3- and NO2- transport.	Nitrogen Dioxide	112-115	uncharacterized protein	Chlamydomonas reinhardtii	75-81
16676969-5	2006	When the system is warmed to 130 K, the disproportionation products, N2O and the O-coordinated nitrito complex Mn(Por)(NO)(ONO) (2), are formed.	Nitrogen Dioxide	123-126	cytochrome p450 oxidoreductase	Homo sapiens	114-117
16916025-7	2006	Significantly high ratios (0.444) of NO3- to NO2 in fine aerosols were present during the local episode, indicating that the relatively high formation rate of NO3 was one of the important factors leading to the increase of the NO3 to PM2.5 ratio during the local episode.	Nitrogen Dioxide	45-48	NBL1, DAN family BMP antagonist	Homo sapiens	159-162
16916025-7	2006	Significantly high ratios (0.444) of NO3- to NO2 in fine aerosols were present during the local episode, indicating that the relatively high formation rate of NO3 was one of the important factors leading to the increase of the NO3 to PM2.5 ratio during the local episode.	Nitrogen Dioxide	45-48	NBL1, DAN family BMP antagonist	Homo sapiens	159-162
16721855-4	2006	Incubation of human intestinal epithelial cells (HT-29) with purified NSP4 but not with infectious virus produced NO2/NO3 accumulation in the incubation media.	Nitrogen Dioxide	114-117	serine protease 57	Homo sapiens	70-74
16722672-4	2006	According to the proposed kinetic scheme, the mutual sensitization of the oxidation of this natural gas blend and NO proceeds through the NO to NO2 conversion by HO2, CH3O2, and C2H5O2.	Nitrogen Dioxide	144-147	heme oxygenase 2	Homo sapiens	162-165
16722672-6	2006	820 K) than at higher temperatures where the reaction of NO with HO2 controls the NO to NO2 conversion.	Nitrogen Dioxide	88-91	heme oxygenase 2	Homo sapiens	65-68
16722672-8	2006	A simplified reaction scheme was delineated: NO + HO2 --> NO2 + OH followed by OH + CH4 --> CH3 + H2O and OH + C2H6 --> C2H5 + H2O.	Nitrogen Dioxide	61-64	heme oxygenase 2	Homo sapiens	50-53
16722672-9	2006	At low-temperature, the reaction also proceeds via CH3 + O2 (+ M) --> CH3O2 (+ M); CH3O2 + NO --> CH3O + NO2 and C2H5 + O2 --> C2H5O2; C2H5O2 + NO --> C2H5O + NO2.	Nitrogen Dioxide	171-174	immunoglobulin kappa variable 1D-39	Homo sapiens	119-128
16722672-13	2006	The kinetic analyses indicate that in the NO-seeded conditions, the main production of OH proceeds via the same route, NO + HO2 --> NO2 + OH.	Nitrogen Dioxide	135-138	heme oxygenase 2	Homo sapiens	124-127
16676969-6	2006	IR spectral changes show that, upon further warming to 200 K, 2 isomerizes into the N-bonded nitro linkage isomer Mn(Por)(NO)(NO2) (3).	Nitrogen Dioxide	126-129	cytochrome p450 oxidoreductase	Homo sapiens	117-120
16676969-7	2006	After it is warmed to room temperature, the latter species loses NO and converts to the known 5-coordinate nitrito complex Mn(Por)(ONO) (4).	Nitrogen Dioxide	131-134	cytochrome p450 oxidoreductase	Homo sapiens	126-129
16527817-4	2006	With rat hepatic microsomes or purified CPR, the presence of NADPH triggered organic nitrate reduction to NO2(-).	Nitrogen Dioxide	106-109	cytochrome p450 oxidoreductase	Rattus norvegicus	40-43
16527817-5	2006	The CPR flavin site inhibitor diphenyleneiodonium inhibited this NO2(-) generation, whereas the CP inhibitor clotrimazole did not.	Nitrogen Dioxide	65-68	cytochrome p450 oxidoreductase	Homo sapiens	4-7
16961293-7	2006	The levels of placental NO2-/NO3- in PIH patients (27.53 +/- 7.48 micromol/mg) were significantly lower than in normal group (54.27 +/- 9.53 micromol/mg, P < 0.01).	Nitrogen Dioxide	24-27	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	37-40
16475181-0	2006	Theoretical mechanistic study on the radical-molecule reaction of CHCl2/CCl3 with NO2.	Nitrogen Dioxide	82-85	C-C motif chemokine ligand 3	Homo sapiens	72-76
16085673-8	2006	Moreover, 20 days postcessation of the 5-day 25 ppm NO2 inhalation regimen, eosinophilic and neutrophilic inflammation, pulmonary lesions, and AHR were still present in mice immunized and challenged with OVA.	Nitrogen Dioxide	52-55	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	204-207
16085673-9	2006	Collectively, these observations suggest an important role for NO2 in airway pathologies associated with asthma, both in modulation of degree and duration of inflammatory response, as well as in induction of AHR.	Nitrogen Dioxide	63-66	aryl-hydrocarbon receptor	Mus musculus	208-211
16040185-8	2006	Enhanced peroxidase activity of nitrated cyt c was responsible for H2O2-induced oxidation of phospholipid membranes and H2O2/NO2--mediated nitration of other proteins.	Nitrogen Dioxide	125-128	cytochrome c, somatic	Homo sapiens	41-46
16526637-1	2006	The heterogeneous reaction of liquid oleic acid aerosol particles with NO3 radicals in the presence of NO2, N2O5, and O2 was investigated in an environmental chamber using a combination of on-line and off-line mass spectrometric techniques.	Nitrogen Dioxide	103-106	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
16568778-6	2006	At an optimum calcination temperature of around 200 degrees C, the Pt ion-doped TiO2 exhibited higher activity in the further oxidation of NO2 to NO3- clearly reducing NO2 selectivity.	Nitrogen Dioxide	139-142	NBL1, DAN family BMP antagonist	Homo sapiens	146-149
16568778-6	2006	At an optimum calcination temperature of around 200 degrees C, the Pt ion-doped TiO2 exhibited higher activity in the further oxidation of NO2 to NO3- clearly reducing NO2 selectivity.	Nitrogen Dioxide	168-171	NBL1, DAN family BMP antagonist	Homo sapiens	146-149
16288932-3	2006	Both penile erection and NO2- increase induced by SR 141716A were reduced by the prior injection into the PVN of the cannabinoid CB1 agonists WIN 55,212-2 (5 microg) or HU 210 (5 microg), given into the paraventricular nucleus at doses unable to induce penile erection or to modify NO2- concentration.	Nitrogen Dioxide	25-28	cannabinoid receptor 1	Rattus norvegicus	129-132
16288932-3	2006	Both penile erection and NO2- increase induced by SR 141716A were reduced by the prior injection into the PVN of the cannabinoid CB1 agonists WIN 55,212-2 (5 microg) or HU 210 (5 microg), given into the paraventricular nucleus at doses unable to induce penile erection or to modify NO2- concentration.	Nitrogen Dioxide	282-285	cannabinoid receptor 1	Rattus norvegicus	129-132
16297853-1	2006	Three unusual substrates-bromide (Br(-)), nitrite (NO(2)(-)), and thiocyanate (SCN(-))-compete for oxidation by eosinophil peroxidase (EPO) in physiologic fluids in the presence of H(2)O(2) to yield, respectively, hypobromous acid (HOBr), nitrogen dioxide (NO(2)()), or hypothiocyanous acid (HOSCN).	Nitrogen Dioxide	239-255	eosinophil peroxidase	Mus musculus	112-133
16297853-1	2006	Three unusual substrates-bromide (Br(-)), nitrite (NO(2)(-)), and thiocyanate (SCN(-))-compete for oxidation by eosinophil peroxidase (EPO) in physiologic fluids in the presence of H(2)O(2) to yield, respectively, hypobromous acid (HOBr), nitrogen dioxide (NO(2)()), or hypothiocyanous acid (HOSCN).	Nitrogen Dioxide	239-255	eosinophil peroxidase	Mus musculus	135-138
16398938-2	2006	Exposure of rats to NO2 has recently been shown to induce a shift in the activation type of AM that is characterized by reduced TNF-alpha and increased IL-10 production.	Nitrogen Dioxide	20-23	tumor necrosis factor	Rattus norvegicus	128-137
16398938-2	2006	Exposure of rats to NO2 has recently been shown to induce a shift in the activation type of AM that is characterized by reduced TNF-alpha and increased IL-10 production.	Nitrogen Dioxide	20-23	interleukin 10	Rattus norvegicus	152-157
16398938-13	2006	CONCLUSION: NO2 exposure induces the infiltration of an AM subpopulation that, on the one hand may exert antiinflammatory functions by the production of high amounts of IL-10 but on the other hand may contribute to the pathology of NO2-induced lung damage by selective expression of certain matrix metalloproteinases.	Nitrogen Dioxide	12-15	interleukin 10	Rattus norvegicus	169-174
16085673-1	2006	In addition to being an air pollutant, NO2 is a potent inflammatory oxidant generated endogenously by myeloperoxidase and eosinophil peroxidase.	Nitrogen Dioxide	39-42	myeloperoxidase	Mus musculus	102-117
16085673-1	2006	In addition to being an air pollutant, NO2 is a potent inflammatory oxidant generated endogenously by myeloperoxidase and eosinophil peroxidase.	Nitrogen Dioxide	39-42	eosinophil peroxidase	Mus musculus	122-143
16085673-5	2006	Importantly, 25 ppm NO2 was also sufficient to cause AHR in mice, a cardinal feature of asthma.	Nitrogen Dioxide	20-23	aryl-hydrocarbon receptor	Mus musculus	53-56
16085673-7	2006	In contrast, in mice immunized and challenged with OVA, inhalation of 25 ppm NO2 caused a marked augmentation of eosinophilic inflammation and terminal bronchiolar lesions, which extended significantly into the alveoli.	Nitrogen Dioxide	77-80	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	51-54
16085673-8	2006	Moreover, 20 days postcessation of the 5-day 25 ppm NO2 inhalation regimen, eosinophilic and neutrophilic inflammation, pulmonary lesions, and AHR were still present in mice immunized and challenged with OVA.	Nitrogen Dioxide	52-55	aryl-hydrocarbon receptor	Mus musculus	143-146
18028616-1	2005	The vibrational modes of the -NO2 group in more than fifty energetic compounds containing the C-nitro and N-nitro functionalities were observed and then calculated in optimized structures using density functional theory (B3LYP/6-31+G*).	Nitrogen Dioxide	30-33	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	223-226
16689253-1	2006	The study with high-pressure mercury lamp illuminating showed that after illuminated for 15 min, NO2- and NO3- quenched the photolysis of mefenacet, and NO3- with a concentration ratio 10:1 (mass) had the most obvious effect, its quenching rate being up to 53.3%.	Nitrogen Dioxide	97-100	NBL1, DAN family BMP antagonist	Homo sapiens	153-156
16170330-7	2005	Analysis of mRNA expression for iNOS, COX-2 and CINC-2 in lung tissue showed an upregulation of these enzymes, which paralleled elevated levels of LTB4, PGE2, TNF-alpha, IL-6 and NO2- in BAL fluid.	Nitrogen Dioxide	179-182	nitric oxide synthase 2	Rattus norvegicus	32-36
16298730-6	2005	In contrast, the nitrogen dioxide-dependent oxidation of NADH and NADPH was decreased by LDH in a SOD-independent manner.	Nitrogen Dioxide	17-33	2,4-dienoyl-CoA reductase 1	Homo sapiens	66-71
16298730-6	2005	In contrast, the nitrogen dioxide-dependent oxidation of NADH and NADPH was decreased by LDH in a SOD-independent manner.	Nitrogen Dioxide	17-33	superoxide dismutase 1	Homo sapiens	98-101
16834249-4	2005	The actual SigmaN proportional, variant [NO3-]1/2 dependence (at constant H) is consistent with NO2 hydrolysis: 2NO2 + H2O --> NO3- + NO2- + 2H+, overtaking NO2 desorption, even below the eutectic point (-18 degrees C for aqueous NaNO3).	Nitrogen Dioxide	96-99	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
16449080-7	2005	The elevated NO2- and NO3- (NO(x-) production by macrophages of MRL-lpr/lpr mice was lowered by the irradiation.	Nitrogen Dioxide	13-16	Fas (TNF receptor superfamily member 6)	Mus musculus	68-71
16449080-7	2005	The elevated NO2- and NO3- (NO(x-) production by macrophages of MRL-lpr/lpr mice was lowered by the irradiation.	Nitrogen Dioxide	13-16	Fas (TNF receptor superfamily member 6)	Mus musculus	72-75
16834249-4	2005	The actual SigmaN proportional, variant [NO3-]1/2 dependence (at constant H) is consistent with NO2 hydrolysis: 2NO2 + H2O --> NO3- + NO2- + 2H+, overtaking NO2 desorption, even below the eutectic point (-18 degrees C for aqueous NaNO3).	Nitrogen Dioxide	96-99	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
16834249-4	2005	The actual SigmaN proportional, variant [NO3-]1/2 dependence (at constant H) is consistent with NO2 hydrolysis: 2NO2 + H2O --> NO3- + NO2- + 2H+, overtaking NO2 desorption, even below the eutectic point (-18 degrees C for aqueous NaNO3).	Nitrogen Dioxide	113-116	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
16834249-4	2005	The actual SigmaN proportional, variant [NO3-]1/2 dependence (at constant H) is consistent with NO2 hydrolysis: 2NO2 + H2O --> NO3- + NO2- + 2H+, overtaking NO2 desorption, even below the eutectic point (-18 degrees C for aqueous NaNO3).	Nitrogen Dioxide	113-116	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
16834249-4	2005	The actual SigmaN proportional, variant [NO3-]1/2 dependence (at constant H) is consistent with NO2 hydrolysis: 2NO2 + H2O --> NO3- + NO2- + 2H+, overtaking NO2 desorption, even below the eutectic point (-18 degrees C for aqueous NaNO3).	Nitrogen Dioxide	113-116	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
16834249-4	2005	The actual SigmaN proportional, variant [NO3-]1/2 dependence (at constant H) is consistent with NO2 hydrolysis: 2NO2 + H2O --> NO3- + NO2- + 2H+, overtaking NO2 desorption, even below the eutectic point (-18 degrees C for aqueous NaNO3).	Nitrogen Dioxide	113-116	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
16834249-5	2005	The increasingly larger NO2 losses detected in longer experiments (at constant [NO3-]) are ascribed to secondary photolysis of trapped NO2.	Nitrogen Dioxide	24-27	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
16834249-5	2005	The increasingly larger NO2 losses detected in longer experiments (at constant [NO3-]) are ascribed to secondary photolysis of trapped NO2.	Nitrogen Dioxide	135-138	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
16240026-2	2005	In situ laser detection using resonance enhanced multiphoton ionization (REMPI) to specifically detect NO2 and NO in the presence of N2O5, NO3 and HNO3 was employed in addition to beam-sampling mass spectrometry.	Nitrogen Dioxide	103-106	NBL1, DAN family BMP antagonist	Homo sapiens	139-142
16240026-4	2005	NO3 adsorbed on mineral dust leads to uptake of NO2 in an Eley-Rideal mechanism that usually is not taken up in the absence of NO3.	Nitrogen Dioxide	48-51	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
16240026-5	2005	The disappearance of NO3 was in part accompanied by the formation of N2O5 and HNO3 in the presence of NO2.	Nitrogen Dioxide	102-105	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
16102752-5	2005	This mini-PDX peptide both cyclic and acyclic form inhibited in vitro furin activity (IC50 in nM) when measured against either substrates Boc-RVRRdown double arrow MCA or QVEGF-C [Abz-QVHSIIRRdown double arrow SLP-Y(NO2)-A-CONH2, Abz=2-amino benzoic acid and Y(NO2)=3-nitro tyrosine], latter being derived from vascular endothelial growth factor-C (VEGF-C) processing site.	Nitrogen Dioxide	216-219	furin, paired basic amino acid cleaving enzyme	Homo sapiens	70-75
16374009-8	2005	Histologic scores after 4 h of reperfusion and myeloperoxidase activity were significantly lower in the ONO group than in the control group.	Nitrogen Dioxide	104-107	myeloperoxidase	Canis lupus familiaris	47-62
16102752-5	2005	This mini-PDX peptide both cyclic and acyclic form inhibited in vitro furin activity (IC50 in nM) when measured against either substrates Boc-RVRRdown double arrow MCA or QVEGF-C [Abz-QVHSIIRRdown double arrow SLP-Y(NO2)-A-CONH2, Abz=2-amino benzoic acid and Y(NO2)=3-nitro tyrosine], latter being derived from vascular endothelial growth factor-C (VEGF-C) processing site.	Nitrogen Dioxide	261-264	furin, paired basic amino acid cleaving enzyme	Homo sapiens	70-75
16109514-1	2005	BACKGROUND: It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2- -derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS)-dependent NO production is impaired.	Nitrogen Dioxide	144-147	xanthine dehydrogenase	Rattus norvegicus	37-60
16853027-5	2005	The stability of the NO(x) formed by exposing the theta-Al2O3 model catalyst to NO2 adsorption increases in the order NO2 (physisorbed or N2O4) < NO2 (chemisorbed) < NO2- < NO3-.	Nitrogen Dioxide	80-83	NBL1, DAN family BMP antagonist	Homo sapiens	182-185
16109514-1	2005	BACKGROUND: It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2- -derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS)-dependent NO production is impaired.	Nitrogen Dioxide	144-147	xanthine dehydrogenase	Rattus norvegicus	62-65
16109514-1	2005	BACKGROUND: It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2- -derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS)-dependent NO production is impaired.	Nitrogen Dioxide	159-162	xanthine dehydrogenase	Rattus norvegicus	37-60
16109514-1	2005	BACKGROUND: It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2- -derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS)-dependent NO production is impaired.	Nitrogen Dioxide	159-162	xanthine dehydrogenase	Rattus norvegicus	62-65
16109514-3	2005	This study was designed to determine whether NO2- -derived NO by XOR protects liver against I/R injury in vivo.	Nitrogen Dioxide	45-48	xanthine dehydrogenase	Rattus norvegicus	65-68
16109514-13	2005	CONCLUSION: NO2- -derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo.	Nitrogen Dioxide	12-15	xanthine dehydrogenase	Rattus norvegicus	32-35
16022734-4	2005	RESULTS: HSPG stimulated up-regulation of tumor necrosis factor-alpha (TNF-alpha), production of inducible nitric oxide synthase (iNOS) mRNA and accumulation of TNF-alpha protein and nitrite (NO2-) in a time- and concentration-dependent manner.	Nitrogen Dioxide	192-195	syndecan 2	Mus musculus	9-13
15958176-6	2005	It was found that the peptides Box(benzfur)-Lys-Phe-Gly-Gly-Tyr(NO2) and Box(benzfur)-Phe-Gly-Gly-Tyr(NO2) were also hydrolyzed by cathepsin B with the highest speed of hydrolysis as a result of carboxypeptidase activity of this enzyme.	Nitrogen Dioxide	102-105	cathepsin B	Homo sapiens	131-142
15571391-0	2004	Kinetics and mechanism of *NO2 reacting with various oxidation states of myoglobin.	Nitrogen Dioxide	27-30	myoglobin	Homo sapiens	73-82
15952386-3	2005	For TiO2 concentrations > or = 1 g/L, the rate constants for NO2 photocatalytic oxidation to NO3 were far more dependent on TiO2 concentration than were those for NH4+/NH3 oxidation to NO2-, suggesting that, without sufficient TiO2, complete oxidation of NH4+/NH3 to NO3- will not occur.	Nitrogen Dioxide	64-67	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
15952386-3	2005	For TiO2 concentrations > or = 1 g/L, the rate constants for NO2 photocatalytic oxidation to NO3 were far more dependent on TiO2 concentration than were those for NH4+/NH3 oxidation to NO2-, suggesting that, without sufficient TiO2, complete oxidation of NH4+/NH3 to NO3- will not occur.	Nitrogen Dioxide	64-67	NBL1, DAN family BMP antagonist	Homo sapiens	270-273
15892615-4	2005	The product of the oxidation (presumably NO2*) directly oxidizes oxyhemoglobin to methemoglobin-peroxide complex without hydrogen peroxide release into the environment.	Nitrogen Dioxide	41-44	hemoglobin subunit gamma 2	Homo sapiens	82-95
16851119-0	2005	The catalytic chemistry of HCN + NO2 over Na- and Ba-Y,FAU: an in situ FTIR and TPD/TPR study.	Nitrogen Dioxide	33-36	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	27-30
16851119-0	2005	The catalytic chemistry of HCN + NO2 over Na- and Ba-Y,FAU: an in situ FTIR and TPD/TPR study.	Nitrogen Dioxide	33-36	translocated promoter region, nuclear basket protein	Homo sapiens	84-87
16851119-3	2005	Over Na-Y, the reaction between HCN and NO(2) is slow at 473 K. On Ba-Y, HCN reacts readily with NO(2) at 473K, forming N(2), CO, CO(2), HNCO, NO, N(2)O, and C(2)N(2).	Nitrogen Dioxide	40-45	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	73-76
16851119-3	2005	Over Na-Y, the reaction between HCN and NO(2) is slow at 473 K. On Ba-Y, HCN reacts readily with NO(2) at 473K, forming N(2), CO, CO(2), HNCO, NO, N(2)O, and C(2)N(2).	Nitrogen Dioxide	97-102	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	32-35
16851119-3	2005	Over Na-Y, the reaction between HCN and NO(2) is slow at 473 K. On Ba-Y, HCN reacts readily with NO(2) at 473K, forming N(2), CO, CO(2), HNCO, NO, N(2)O, and C(2)N(2).	Nitrogen Dioxide	97-102	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	73-76
15707067-4	2005	Reduction of NO3- by corroding iron resulted in near stoichiometric production of NO2-, which did not measurably react in the absence of added Fe(II).	Nitrogen Dioxide	82-85	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
15998241-2	2005	Peroxynitrite (ONOO-) and nitrogen dioxide (NO2) inhibit TH catalytic function and cause nitration of protein tyrosine residues.	Nitrogen Dioxide	26-42	tyrosine hydroxylase	Homo sapiens	57-59
15998241-2	2005	Peroxynitrite (ONOO-) and nitrogen dioxide (NO2) inhibit TH catalytic function and cause nitration of protein tyrosine residues.	Nitrogen Dioxide	44-47	tyrosine hydroxylase	Homo sapiens	57-59
15998241-3	2005	Exposure of TH to either ONOO- or NO2 in the presence of cysteine (or glutathione) prevents tyrosine nitration and results in S-thiolation instead.	Nitrogen Dioxide	34-37	tyrosine hydroxylase	Homo sapiens	12-14
15998241-10	2005	Taken together, these results show that TH is S-thiolated by ONOO- or NO2 in the presence of cysteine.	Nitrogen Dioxide	70-73	tyrosine hydroxylase	Homo sapiens	40-42
16839062-0	2005	Kinetics of the reactions of chlorinated methyl radicals (CH2Cl, CHCl2, and CCl3) with NO2 in the temperature range 220-360 K. The kinetics of the reactions of chlorinated methyl radicals (CH2Cl, CHCl2, and CCl3) with NO2 have been studied in direct measurements at temperatures between 220 and 360 K using a tubular flow reactor coupled to a photoionization mass spectrometer.	Nitrogen Dioxide	87-90	C-C motif chemokine ligand 3	Homo sapiens	76-80
15952386-3	2005	For TiO2 concentrations > or = 1 g/L, the rate constants for NO2 photocatalytic oxidation to NO3 were far more dependent on TiO2 concentration than were those for NH4+/NH3 oxidation to NO2-, suggesting that, without sufficient TiO2, complete oxidation of NH4+/NH3 to NO3- will not occur.	Nitrogen Dioxide	188-191	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
15952386-7	2005	Initial rates of NO2- photocatalytic oxidation were 1 order of magnitude higher for NO2- versus NH4+/NH3, indicating thatthe rate of NH4+/NH3 photocatalytic oxidation to NO3- was limited by NH4+/NH3 oxidation to NO2- under our experimental conditions.	Nitrogen Dioxide	17-20	NBL1, DAN family BMP antagonist	Homo sapiens	170-173
15952386-7	2005	Initial rates of NO2- photocatalytic oxidation were 1 order of magnitude higher for NO2- versus NH4+/NH3, indicating thatthe rate of NH4+/NH3 photocatalytic oxidation to NO3- was limited by NH4+/NH3 oxidation to NO2- under our experimental conditions.	Nitrogen Dioxide	84-87	NBL1, DAN family BMP antagonist	Homo sapiens	170-173
15952386-7	2005	Initial rates of NO2- photocatalytic oxidation were 1 order of magnitude higher for NO2- versus NH4+/NH3, indicating thatthe rate of NH4+/NH3 photocatalytic oxidation to NO3- was limited by NH4+/NH3 oxidation to NO2- under our experimental conditions.	Nitrogen Dioxide	84-87	NBL1, DAN family BMP antagonist	Homo sapiens	170-173
15812021-4	2005	With 100 microM NO3-, no significant transient accumulation of NO2- could be measured, and the starting concentration of NO2- could therefore be regulated.	Nitrogen Dioxide	121-124	NBL1, DAN family BMP antagonist	Homo sapiens	16-19
15812021-8	2005	Decreasing the concentration of NO3- but holding NO2- at 5 microM decreased the significance of anammox as a sink for NO2-.	Nitrogen Dioxide	118-121	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
15948594-6	2005	The amount of UN derived from NO2 was greatly increased in the transgenic tobacco clone 271 (Vaucheret et al., 1992) where the activity of nitrite reductase is suppressed less than 5% of that of the wild-type plant.	Nitrogen Dioxide	30-33	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	139-156
15763961-0	2005	Spin trapping of nitrogen dioxide and of radicals generated from nitrous acid.	Nitrogen Dioxide	17-33	spindlin 1	Homo sapiens	0-4
15763961-2	2005	The reaction results in the formation of persistent acyl nitroxides, after the oxidation of the intermediate spin adducts having an -ONO group on C-2 atom.	Nitrogen Dioxide	133-136	spindlin 1	Homo sapiens	109-113
15763961-2	2005	The reaction results in the formation of persistent acyl nitroxides, after the oxidation of the intermediate spin adducts having an -ONO group on C-2 atom.	Nitrogen Dioxide	133-136	complement C2	Homo sapiens	146-149
15912211-4	2005	Peroxynitrite reacts with SDS-modified cytochrome c in the same way as with native cytochrome c, via intermediate radical products, *OH/*NO2, arising from peroxynitrite homolysis.	Nitrogen Dioxide	137-140	cytochrome c, somatic	Homo sapiens	39-51
15912211-4	2005	Peroxynitrite reacts with SDS-modified cytochrome c in the same way as with native cytochrome c, via intermediate radical products, *OH/*NO2, arising from peroxynitrite homolysis.	Nitrogen Dioxide	137-140	cytochrome c, somatic	Homo sapiens	83-95
15667129-6	2005	The overall endothermicity of the NO2 + ClO --> NO3 + Cl reaction is calculated to be 16.6 kcal mol(-1).	Nitrogen Dioxide	34-37	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
15318813-4	2004	In L-929 cells, SIN-1 produced nitric oxide (*NO) as monitored by the fluorescent *NO scavenger FNOCT-1 and by means of a *NO electrode, as well as reactive nitrogenoxide species (RNOS, e.g. peroxynitrite, nitrogen dioxide, dinitrogen trioxide), as detected with the fluorescent indicator DAF-2.	Nitrogen Dioxide	206-222	mitogen-activated protein kinase associated protein 1	Mus musculus	16-21
15491653-4	2004	Presently, we found that photolysis of the rigid molecule CL-20 produced NO2-, NO3-, NH3, HCOOH, N2 and N2O.	Nitrogen Dioxide	73-76	epithelial membrane protein 1	Homo sapiens	58-63
15451064-4	2004	The reaction of NO2- with oxyHb was accelerated at high heme concentrations and produced stoichiometric amounts of NO3-.	Nitrogen Dioxide	16-19	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
15303165-0	2004	The reaction of Li[Al(OR)4] R = OC(CF3)2Ph, OC(CF3)3 with NO/NO2 giving NO[Al(OR)4], Li[NO3] and N2O.	Nitrogen Dioxide	61-64	NBL1, DAN family BMP antagonist	Homo sapiens	88-91
15354951-0	2004	[Oxides of nitrogen (NO* and NO2-) as cofactors of the myeloperoxidase system].	Nitrogen Dioxide	29-32	myeloperoxidase	Homo sapiens	55-70
15354951-9	2004	Nitrogen dioxide is formed after nitrite oxidation by myeloperoxidase.	Nitrogen Dioxide	0-16	myeloperoxidase	Homo sapiens	54-69
15003325-6	2004	A marked increase in the levels of nitrite (as an index of NO) and IL-8 were observed in the NO2-exposed cells, which were further enhanced in the presence of the cytokines.	Nitrogen Dioxide	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
15003325-8	2004	Furthermore, a significant increase in IL-1beta and TNF-alpha generation was observed in the NO2-exposed cells.	Nitrogen Dioxide	93-96	interleukin 1 beta	Homo sapiens	39-47
15003325-8	2004	Furthermore, a significant increase in IL-1beta and TNF-alpha generation was observed in the NO2-exposed cells.	Nitrogen Dioxide	93-96	tumor necrosis factor	Homo sapiens	52-61
15003325-10	2004	These results suggest a synergistic role of inflammatory mediators, particularly of NO and IL-8, in NO2-mediated early cellular changes.	Nitrogen Dioxide	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
15037072-2	2004	Protein cleavage sites for the Ricinus CysEP were determined with fluorogenic peptides (Abz-Xaa-Arg-/-Gln-Gln-Tyr(NO2)-Asp).	Nitrogen Dioxide	114-117	vignain	Ricinus communis	39-44
14640973-8	2004	Irradiation of [(NH3)5CoCO3]+ and NO2- in the presence of alpha-synuclein yielded nitration and aggregation products that were similar to those obtained from a SIN-1 (or slowly infused ONOO-) and HCO3- or a myeloperoxidase/H2O2/NO2- system.	Nitrogen Dioxide	34-37	synuclein alpha	Homo sapiens	58-73
14640973-8	2004	Irradiation of [(NH3)5CoCO3]+ and NO2- in the presence of alpha-synuclein yielded nitration and aggregation products that were similar to those obtained from a SIN-1 (or slowly infused ONOO-) and HCO3- or a myeloperoxidase/H2O2/NO2- system.	Nitrogen Dioxide	228-231	synuclein alpha	Homo sapiens	58-73
14640973-10	2004	We conclude that both CO3*- and NO2* could play a major role in the nitration/aggregation of alpha-synuclein.	Nitrogen Dioxide	32-35	synuclein alpha	Homo sapiens	93-108
14723523-2	2004	The association constants strongly depend on the substituents, varying up to DeltaDeltaG = 3.4 kcal/mol; electron-donating substituents (OMe, NMe2) decrease the binding affinity, while electron-withdrawing groups (Cl, NO2) increase it.	Nitrogen Dioxide	218-221	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	142-146
15202244-9	2004	Reversal the polarity of NUEK weakened the concentration of NO3- to electrodes, but it stimulated the transformation of NO3- to NO2- and further lowered the electric energy consumption.	Nitrogen Dioxide	128-131	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
15135358-1	2004	In alkaline solutions, nitroalkanes (RCH2NO2) undergo deprotonation and rearrange to an aci anion (RHC=NO2-), which may function as a spin trap.	Nitrogen Dioxide	41-44	spindlin 1	Homo sapiens	134-138
15050533-9	2004	Serum NO2-/NO3- levels, an indicator of total body NO synthesis, decreased significantly when eNOS+/+ mice were treated with dexamethasone.	Nitrogen Dioxide	6-9	nitric oxide synthase 3, endothelial cell	Mus musculus	94-98
15050533-10	2004	eNOS-/- mice had lower serum NO2-/NO3- levels per se, which were not changed significantly by dexamethasone.	Nitrogen Dioxide	29-32	nitric oxide synthase 3, endothelial cell	Mus musculus	0-4
14573760-4	2003	However, the mitochondrial aldehyde dehydrogenase (ALDH2) is inhibited in GTN-tolerant tissues and produces NO2- from GTN, which is proposed to be converted to NO within mitochondria.	Nitrogen Dioxide	108-111	aldehyde dehydrogenase 2 family member	Rattus norvegicus	13-49
14753679-7	2004	Finally, CL-20 was found to decompose in non-acidified water upon contact with glass containers to give NO2- (2 equiv.	Nitrogen Dioxide	104-107	epithelial membrane protein 1	Homo sapiens	9-14
14678790-3	2004	We report herein a novel function for cytochrome c as a catalyst for nitrite (NO2-) and hydrogen peroxide (H2O2)-mediated nitration reactions.	Nitrogen Dioxide	78-81	cytochrome c, somatic	Homo sapiens	38-50
14678790-4	2004	Cytochrome c catalyzes both self- and adjacent-molecule (hydroxyphenylacetic acid, Mn-superoxide dismutase) nitration via heme-dependent mechanisms involving tyrosyl radical and *NO2 production, as for phagocyte peroxidases.	Nitrogen Dioxide	179-182	cytochrome c, somatic	Homo sapiens	0-12
14678790-4	2004	Cytochrome c catalyzes both self- and adjacent-molecule (hydroxyphenylacetic acid, Mn-superoxide dismutase) nitration via heme-dependent mechanisms involving tyrosyl radical and *NO2 production, as for phagocyte peroxidases.	Nitrogen Dioxide	179-182	superoxide dismutase 2	Homo sapiens	83-106
14678790-7	2004	Extensive tyrosine nitration of Mn-superoxide dismutase occurred when exposed to either cytochrome c or MPx-11 in the presence of H2O2 and NO2-, with no apparent decrease in catalytic activity.	Nitrogen Dioxide	139-142	superoxide dismutase 2	Homo sapiens	32-55
14678790-7	2004	Extensive tyrosine nitration of Mn-superoxide dismutase occurred when exposed to either cytochrome c or MPx-11 in the presence of H2O2 and NO2-, with no apparent decrease in catalytic activity.	Nitrogen Dioxide	139-142	cytochrome c, somatic	Homo sapiens	88-100
12960269-5	2003	In the presence of hydrogen peroxide and nitrite (NO2-; hereafter called EPO with substrates), EPO catalyzes the formation of nitrogen dioxide.	Nitrogen Dioxide	50-53	eosinophil peroxidase	Homo sapiens	73-76
12960269-5	2003	In the presence of hydrogen peroxide and nitrite (NO2-; hereafter called EPO with substrates), EPO catalyzes the formation of nitrogen dioxide.	Nitrogen Dioxide	50-53	eosinophil peroxidase	Homo sapiens	95-98
12960269-5	2003	In the presence of hydrogen peroxide and nitrite (NO2-; hereafter called EPO with substrates), EPO catalyzes the formation of nitrogen dioxide.	Nitrogen Dioxide	126-142	eosinophil peroxidase	Homo sapiens	73-76
12960269-5	2003	In the presence of hydrogen peroxide and nitrite (NO2-; hereafter called EPO with substrates), EPO catalyzes the formation of nitrogen dioxide.	Nitrogen Dioxide	126-142	eosinophil peroxidase	Homo sapiens	95-98
14573760-4	2003	However, the mitochondrial aldehyde dehydrogenase (ALDH2) is inhibited in GTN-tolerant tissues and produces NO2- from GTN, which is proposed to be converted to NO within mitochondria.	Nitrogen Dioxide	108-111	aldehyde dehydrogenase 2 family member	Rattus norvegicus	51-56
15495951-8	2004	Complete photo-oxidation of nitrogen to NO3- occurred very slowly via the intermediate formation of NH4+ and NO2-.	Nitrogen Dioxide	109-112	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
14658904-1	2003	Interaction of a low-pressure NO2 with sublimed layers of (meso-tetraphenylporphyrinato)cobalt(II) (Co(TPP)) leads to formation of 5-coordinate nitro complex Co(III)(TPP)(NO2).	Nitrogen Dioxide	30-33	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	158-165
14658904-1	2003	Interaction of a low-pressure NO2 with sublimed layers of (meso-tetraphenylporphyrinato)cobalt(II) (Co(TPP)) leads to formation of 5-coordinate nitro complex Co(III)(TPP)(NO2).	Nitrogen Dioxide	171-174	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	158-165
14658904-2	2003	Upon exposure of these layers to pyridine vapors, the fast reaction with formation of 6-coordinate nitro-pyridine porphyrins (Py)Co(III)(TPP)(NO2) occurs.	Nitrogen Dioxide	142-146	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	129-136
14659696-3	2003	Several reactions mediate protein nitration, and all predominantly depend on z.rad;NO- and nitrite-dependent formation of nitrogen dioxide, a species capable of nitrating aromatic amino acids, nucleotides and unsaturated fatty acids.	Nitrogen Dioxide	122-138	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	79-82
14573722-1	2003	BACKGROUND: Repeated daily exposure of healthy human subjects to NO2 induces an acute airway inflammatory response characterised by neutrophil influx in the bronchial mucosa AIMS: To assess the expression of NF-kappaB, cytokines, and ICAM-1 in the bronchial epithelium.	Nitrogen Dioxide	65-68	nuclear factor kappa B subunit 1	Homo sapiens	208-217
14573722-1	2003	BACKGROUND: Repeated daily exposure of healthy human subjects to NO2 induces an acute airway inflammatory response characterised by neutrophil influx in the bronchial mucosa AIMS: To assess the expression of NF-kappaB, cytokines, and ICAM-1 in the bronchial epithelium.	Nitrogen Dioxide	65-68	intercellular adhesion molecule 1	Homo sapiens	234-240
14573722-0	2003	Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL-5, IL-10, IL-13, and ICAM-1 in the bronchial epithelium of healthy human airways.	Nitrogen Dioxide	33-49	interleukin 5	Homo sapiens	80-84
14573722-5	2003	RESULTS: Expression of IL-5, IL-10, IL-13, and ICAM-1 increased following NO2 exposure.	Nitrogen Dioxide	74-77	interleukin 5	Homo sapiens	23-27
14573722-0	2003	Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL-5, IL-10, IL-13, and ICAM-1 in the bronchial epithelium of healthy human airways.	Nitrogen Dioxide	33-49	interleukin 10	Homo sapiens	86-91
14573722-5	2003	RESULTS: Expression of IL-5, IL-10, IL-13, and ICAM-1 increased following NO2 exposure.	Nitrogen Dioxide	74-77	interleukin 10	Homo sapiens	29-34
14573722-0	2003	Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL-5, IL-10, IL-13, and ICAM-1 in the bronchial epithelium of healthy human airways.	Nitrogen Dioxide	33-49	interleukin 13	Homo sapiens	93-98
14573722-5	2003	RESULTS: Expression of IL-5, IL-10, IL-13, and ICAM-1 increased following NO2 exposure.	Nitrogen Dioxide	74-77	interleukin 13	Homo sapiens	36-41
14573722-0	2003	Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL-5, IL-10, IL-13, and ICAM-1 in the bronchial epithelium of healthy human airways.	Nitrogen Dioxide	33-49	intercellular adhesion molecule 1	Homo sapiens	104-110
14573722-5	2003	RESULTS: Expression of IL-5, IL-10, IL-13, and ICAM-1 increased following NO2 exposure.	Nitrogen Dioxide	74-77	intercellular adhesion molecule 1	Homo sapiens	47-53
14573722-7	2003	Upregulation of ICAM-1 highlights an underlying mechanism for leucocyte influx, and could also explain the predisposition to respiratory tract viral infections following NO2 exposure since ICAM-1 is a major receptor for rhino and respiratory syncytial viruses.	Nitrogen Dioxide	170-173	intercellular adhesion molecule 1	Homo sapiens	16-22
14573722-7	2003	Upregulation of ICAM-1 highlights an underlying mechanism for leucocyte influx, and could also explain the predisposition to respiratory tract viral infections following NO2 exposure since ICAM-1 is a major receptor for rhino and respiratory syncytial viruses.	Nitrogen Dioxide	170-173	intercellular adhesion molecule 1	Homo sapiens	189-195
15011737-12	2003	CONCLUSIONS: Our results suggest that the method described here could be considered as an alternative instead of commercial kits to determine NO2- + NO3- in plasma and ascites samples.	Nitrogen Dioxide	142-145	NBL1, DAN family BMP antagonist	Homo sapiens	149-152
15143516-2	2003	The activity of acetylcholinesterase in suspension of cells compounds is 9.8 +/- 0.2 mumol of tiocholinbromide/mg protein/hour and is reduced under influence of exogenous ATP, NO2-, H2O2 and Triton X-100.	Nitrogen Dioxide	176-180	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-36
14500751-0	2003	Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide.	Nitrogen Dioxide	84-100	tyrosine hydroxylase	Homo sapiens	42-62
12926008-1	2003	The atmospheric reaction NO2 + O3 --> NO3 + O2 (1) has been investigated theoretically by using the MP2, G2, G2Q, QCISD, QCISD(T), CCSD(T), CASSCF, and CASPT2 methods with various basis sets.	Nitrogen Dioxide	25-28	tryptase pseudogene 1	Homo sapiens	103-106
12892664-5	2003	Moreover, the high sulfate and nitrate conversion values (SOR and NOR) presented herein suggest that secondary formations from SO2 to SO4(2-) and from NO2 to NO3- are present in significant quantities in the atmosphere of southern Taiwan on episode days.	Nitrogen Dioxide	151-154	NBL1, DAN family BMP antagonist	Homo sapiens	158-161
14500751-2	2003	TH is inhibited and nitrated at tyrosine residues in vitro by the reactive nitrogen species peroxynitrite and nitrogen dioxide (NO2) and in vivo by drugs that damage dopamine neurons.	Nitrogen Dioxide	110-126	tyrosine hydroxylase	Homo sapiens	0-2
14500751-2	2003	TH is inhibited and nitrated at tyrosine residues in vitro by the reactive nitrogen species peroxynitrite and nitrogen dioxide (NO2) and in vivo by drugs that damage dopamine neurons.	Nitrogen Dioxide	128-131	tyrosine hydroxylase	Homo sapiens	0-2
14500751-3	2003	Tetrahydrobiopterin, which is the essential cofactor for TH and is concentrated in dopamine neurons, completely blocks nitration of tyrosine residues in TH caused by peroxynitrite or NO2.	Nitrogen Dioxide	183-186	tyrosine hydroxylase	Homo sapiens	153-155
14500751-8	2003	Using an enhanced green fluorescent protein-TH fusion construct as a real-time reporter of intracellular tyrosine nitration, tetrahydrobiopterin was found to prevent NO2-induced tyrosine nitration in intact cells but to leave TH activity inhibited.	Nitrogen Dioxide	166-169	tyrosine hydroxylase	Homo sapiens	44-46
14611112-4	2003	RESULTS: LPS significantly increased NO2-; PGE2 and TNF-alpha levels by 24 h. Quantitative real-time PCR demonstrated a dose-dependent reduction in the expression of COX-2 in the presence of increasing doses of L-NAME.	Nitrogen Dioxide	37-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
12927686-3	2003	The NO3- was first reduced to NO2-, and total NO2- was detected by colorimetric Griess reaction.	Nitrogen Dioxide	30-33	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
12927686-3	2003	The NO3- was first reduced to NO2-, and total NO2- was detected by colorimetric Griess reaction.	Nitrogen Dioxide	46-49	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
14719272-3	2003	The release of NO3(-)-N is most marked, the increasing concentration of NO3(-)-N, NH4(+)-N, NO2(-)-N and DIP reach in turns: 11.869 mumol.L-1, 2.1713 mumol.L-1, 0.2 mumol.L-1, 0.02 mumol.L-1.	Nitrogen Dioxide	92-95	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
14719272-3	2003	The release of NO3(-)-N is most marked, the increasing concentration of NO3(-)-N, NH4(+)-N, NO2(-)-N and DIP reach in turns: 11.869 mumol.L-1, 2.1713 mumol.L-1, 0.2 mumol.L-1, 0.02 mumol.L-1.	Nitrogen Dioxide	92-95	NBL1, DAN family BMP antagonist	Homo sapiens	72-75
14681996-5	2003	The NO2- biosynthesis by stroma cells is strongly inhibited by the agents, which super produce H2O2(O2-) (salicylate and cytochrome c).	Nitrogen Dioxide	4-7	cytochrome c	Sus scrofa	121-133
12771134-3	2003	Exposure of TH to peroxynitrite or NO2 results in nitration of tyrosine residues and modification of cysteines in the enzyme as well as inactivation of catalytic activity.	Nitrogen Dioxide	35-38	tyrosine hydroxylase	Homo sapiens	12-14
12771134-4	2003	Dopamine (DA), its precursor 3,4-dihydroxyphenylalanine, and metabolite 3,4-dihydroxyphenylacetic acid completely block the nitrating effects of peroxynitrite and NO2 on TH but do not relieve the enzyme from inhibition.	Nitrogen Dioxide	163-166	tyrosine hydroxylase	Homo sapiens	170-172
12771134-5	2003	o-Quinones formed in the reaction of catechols with either peroxynitrite or NO2 react with cysteine residues in TH and inhibit catalytic function.	Nitrogen Dioxide	76-79	tyrosine hydroxylase	Homo sapiens	112-114
12771134-6	2003	Using direct, real-time evaluation of tyrosine nitration with a green fluorescent protein-TH fusion protein stably expressed in intact cells (also stably expressing the human DA transporter), DA was also found to prevent NO2-induced nitration while leaving TH activity inhibited.	Nitrogen Dioxide	221-224	tyrosine hydroxylase	Homo sapiens	90-92
14574739-2	2003	The decrease of Ca2+ affinity for calmodulin and limiting quantity of the sites of cation cross-linking by the protein molecule under the effect of 1 nM NO2 and 10 nM H2O2.	Nitrogen Dioxide	153-156	calmodulin 1	Homo sapiens	34-44
12771134-6	2003	Using direct, real-time evaluation of tyrosine nitration with a green fluorescent protein-TH fusion protein stably expressed in intact cells (also stably expressing the human DA transporter), DA was also found to prevent NO2-induced nitration while leaving TH activity inhibited.	Nitrogen Dioxide	221-224	solute carrier family 6 member 3	Homo sapiens	175-189
12771134-6	2003	Using direct, real-time evaluation of tyrosine nitration with a green fluorescent protein-TH fusion protein stably expressed in intact cells (also stably expressing the human DA transporter), DA was also found to prevent NO2-induced nitration while leaving TH activity inhibited.	Nitrogen Dioxide	221-224	tyrosine hydroxylase	Homo sapiens	257-259
12805624-6	2003	Accordingly, nitrite (NO2-) strongly represses NRT1.1 and NIA1 transcript accumulation in the roots.	Nitrogen Dioxide	22-25	nitrate transporter 1.1	Arabidopsis thaliana	47-51
12805624-6	2003	Accordingly, nitrite (NO2-) strongly represses NRT1.1 and NIA1 transcript accumulation in the roots.	Nitrogen Dioxide	22-25	nitrate reductase 1	Arabidopsis thaliana	58-62
12805624-8	2003	Furthermore, transport studies on plants exposed to NO2- show that down-regulation of the NRT1.1 gene is associated with a decrease in NO3- influx.	Nitrogen Dioxide	52-55	nitrate transporter 1.1	Arabidopsis thaliana	90-96
12588285-13	2003	CONCLUSIONS: In uncomplicated patients with FH, plasma NO2/NO3 concentrations are elevated; the cross-sectional data, intervention study and in vitro experiments indicate that oxidized lipids exert a tonic stimulatory action on e-NOS and NO2/NO3 generation not mediated through superoxide anion formation.	Nitrogen Dioxide	55-58	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
12564902-5	2003	The reactions of naphthalene and the alkylnaphthalenes with NO3 radicals proceed by initial addition of the radical to form an aromatic-NO3 adduct (with rate constant k(a)) which either decomposes back to reactants (with rate constant kb) or reacts with NO2 to form products (with rate constant k(c).	Nitrogen Dioxide	254-257	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
12564902-5	2003	The reactions of naphthalene and the alkylnaphthalenes with NO3 radicals proceed by initial addition of the radical to form an aromatic-NO3 adduct (with rate constant k(a)) which either decomposes back to reactants (with rate constant kb) or reacts with NO2 to form products (with rate constant k(c).	Nitrogen Dioxide	254-257	NBL1, DAN family BMP antagonist	Homo sapiens	136-139
14574739-1	2003	The effect of NO2- and H2O2 on Ca(2+)-binding properties of calmodulin has been studied.	Nitrogen Dioxide	14-17	calmodulin 1	Homo sapiens	60-70
12884412-5	2003	At these concentrations, SNAP and SIN-1 released about the same amount (100 microM) of NO or ONO(2)(-), respectively, as monitored by measuring NO(2)(-) + NO(3)(-).	Nitrogen Dioxide	93-97	MAPK associated protein 1	Homo sapiens	34-39
12588285-5	2003	In HMEC-1, NO2/NO3 was also determined after exposure to more intensively oxidized LDLs.	Nitrogen Dioxide	11-14	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
14574739-4	2003	The investigation results indicate to possible inhibition of Ca(2+)-calmodulin-dependent cytosole reaction of the smooth-muscle cells under the effect of NO2 and H2O2, and this will result in the myometrium relaxation.	Nitrogen Dioxide	154-157	calmodulin 1	Homo sapiens	68-78
12359714-4	2002	For example, MPO catalyzes oxidation of tyrosine and nitrite to form tyrosyl radical and nitrogen dioxide ((.	Nitrogen Dioxide	89-105	myeloperoxidase	Mus musculus	13-16
12490044-0	2002	Effect of nitrogen dioxide on ovalbumin-induced allergic airway disease in a murine model.	Nitrogen Dioxide	10-26	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	30-39
12521176-3	2002	While the slow photocatalytic oxidation of NH3 to NO2-/NO3- is the only pathway for decomposition of NH3 on naked TiO2 and Au/TiO2, a new pathway, that of selective oxidation of ammonia to dinitrogen, opens up on Pt/TiO2.	Nitrogen Dioxide	50-53	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
12450113-1	2002	The appearance of NO2- reducing activity of cytochrome c (Cyt c) upon heat denaturation was investigated with equine heart Cyt c.	Nitrogen Dioxide	18-21	cytochrome c, somatic	Equus caballus	44-56
12451238-7	2002	Moreover, although TNF-alpha levels were significantly raised in HTx recipients compared with both healthy controls and individuals with essential hypertension, it was positively correlated to 24-hour BP and NO2(-) + NO3(-).	Nitrogen Dioxide	208-211	tumor necrosis factor	Homo sapiens	19-28
12450113-1	2002	The appearance of NO2- reducing activity of cytochrome c (Cyt c) upon heat denaturation was investigated with equine heart Cyt c.	Nitrogen Dioxide	18-21	cytochrome c, somatic	Equus caballus	58-63
12450113-1	2002	The appearance of NO2- reducing activity of cytochrome c (Cyt c) upon heat denaturation was investigated with equine heart Cyt c.	Nitrogen Dioxide	18-21	cytochrome c, somatic	Equus caballus	123-128
12450113-2	2002	Denatured equine heart Cyt c (dCyt c), which was treated at 100 degrees C for 30 min, had NO2- reducing activity in the presence of dithionite and methylviologen in an aqueous solution under anaerobic conditions.	Nitrogen Dioxide	90-93	cytochrome c, somatic	Equus caballus	23-28
12450113-2	2002	Denatured equine heart Cyt c (dCyt c), which was treated at 100 degrees C for 30 min, had NO2- reducing activity in the presence of dithionite and methylviologen in an aqueous solution under anaerobic conditions.	Nitrogen Dioxide	90-93	Cytochrome c distal	Drosophila melanogaster	30-36
12450113-5	2002	The dCyt c catalyzed NO2- reduction to NH4+ via ferrous-NO complexes, and this reaction was a 6-electron and 8-proton reduction.	Nitrogen Dioxide	21-24	Cytochrome c distal	Drosophila melanogaster	4-10
12230195-4	2002	This membrane technology supported excellent NO3- and nitrite (NO2-) removal once H2 and carbon limitations were corrected.	Nitrogen Dioxide	63-66	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
12361810-3	2002	While NO(2)Tyr has been considered a marker of peroxynitrite (ONOO(-)) formation previously, there is growing evidence that heme-protein peroxidase activity, in particular neutrophil-derived myeloperoxidase (MPO), significantly contributes to NO(2)Tyr formation in vivo via the oxidation of nitrite (NO(2)(-)) to nitrogen dioxide (.NO(2)).	Nitrogen Dioxide	313-329	myeloperoxidase	Homo sapiens	191-206
12361810-8	2002	Finally, lung tissue from MPO(-/-) mice, having tissue inflammatory responses stimulated by intraperitoneal zymosan administration, revealed less subendothelial NO(2)Tyr immunoreactivity than tissue from wild-type mice, confirming the significant role that MPO plays in catalyzing tissue nitration reactions.	Nitrogen Dioxide	161-166	myeloperoxidase	Mus musculus	26-29
12200115-3	2002	The removal of RDX was accompanied by the formation and accumulation of nitrite ion (NO(2)(-)), formaldehyde (HCHO), ammonium (NH(4)(+)), and nitrous oxide (N(2)O).	Nitrogen Dioxide	85-90	radixin	Homo sapiens	15-18
12175231-6	2002	Furthermore, in the presence of excess NO2, the latter undergoes oxidation to the stable nitrato analogue Fe(TPP)(NO3) (5).	Nitrogen Dioxide	39-42	NBL1, DAN family BMP antagonist	Homo sapiens	114-117
12196004-3	2002	The reported NO2 absorption efficiency of the method of 82% at a flow rate of 0.2 l min-1 was found to be as low as 33% at a flow rate of 1.0 l min-1 for a sampling duration of 24 h. Similarly, a considerable decrease in absorption efficiency with increasing sampling duration from 2 to 24 h was observed at a particular flow rate.	Nitrogen Dioxide	13-16	CD59 molecule (CD59 blood group)	Homo sapiens	84-89
12175231-11	2002	The rapid dilution experiments also demonstrated that Fe(TPP)(NO2) readily undergoes further oxidation to give Fe(TPP)(NO3).	Nitrogen Dioxide	62-65	NBL1, DAN family BMP antagonist	Homo sapiens	119-122
12117643-4	2002	Independently, RV16, NO2, and O3 rapidly increased release of the inflammatory cytokine interleukin-8 through oxidant-dependent mechanisms.	Nitrogen Dioxide	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
12180127-7	2002	For the acute lung injury (3 d NO2), the expression of CuZnSOD mRNA was significantly increased, while MnSOD expression was significantly reduced after 3 days of NO2 exposure.	Nitrogen Dioxide	31-34	superoxide dismutase 1	Rattus norvegicus	55-62
12084007-4	2002	In the application of chronic obstructive pulmonary disease therapy, the human neutrophil elastase inhibitors mainly focused upon include ONO-5046, MR-889, L-694,458, CE-1037, GW-311616 and TEI-8362 as the acyl-enzyme inhibitors; and ONO-6818, AE-3763, FK-706, ICI-200,880, ZD-0892 and ZD-8321 as the transition-state inhibitors.	Nitrogen Dioxide	138-141	elastase, neutrophil expressed	Homo sapiens	79-98
12180127-7	2002	For the acute lung injury (3 d NO2), the expression of CuZnSOD mRNA was significantly increased, while MnSOD expression was significantly reduced after 3 days of NO2 exposure.	Nitrogen Dioxide	31-34	superoxide dismutase 2	Rattus norvegicus	103-108
12180127-10	2002	Total SOD enzyme activity showed a significant decrease after 3 days of NO2 exposure and was similar to control after 20 days.	Nitrogen Dioxide	72-75	superoxide dismutase 1	Rattus norvegicus	6-9
12455733-7	2002	A rate constant per unit O2 concentration of 9.40E-10 ppm(-2) min(-1) for humidified gas was significantly higher than 8.27E-10 ppm(-2) min(-1) for "dry" gas (P = 0.008) at 22 degrees C. Rise in NO2 predicted from the "wet" rate constant achieved 3ppm in 65 seconds with 40 ppm NO in 100% oxygen and 107 sec.	Nitrogen Dioxide	195-198	CD59 molecule (CD59 blood group)	Homo sapiens	62-68
12132579-3	2002	NO production (NO2-), indicating iNOS activity, was much higher in the young rat hepatocytes following stimulation with LPS or IL-1beta.	Nitrogen Dioxide	15-18	nitric oxide synthase 2	Rattus norvegicus	33-37
12132579-3	2002	NO production (NO2-), indicating iNOS activity, was much higher in the young rat hepatocytes following stimulation with LPS or IL-1beta.	Nitrogen Dioxide	15-18	interleukin 1 beta	Rattus norvegicus	127-135
12108522-6	2002	GHRH and GnRH failed to change medium NO2- levels, but they elicited increases in medium NO2- levels in estrogen-treated cells.	Nitrogen Dioxide	89-92	growth hormone releasing hormone	Rattus norvegicus	0-4
12108522-6	2002	GHRH and GnRH failed to change medium NO2- levels, but they elicited increases in medium NO2- levels in estrogen-treated cells.	Nitrogen Dioxide	89-92	gonadotropin releasing hormone 1	Rattus norvegicus	9-13
12108522-7	2002	The GHRH-induced increase in NO2- level was inhibited by Nomega-nitro-L-arginine methyl ester, a NOS inhibitor.	Nitrogen Dioxide	29-32	growth hormone releasing hormone	Rattus norvegicus	4-8
12037614-2	2002	Porewater extractions revealed ecotoxicologically critical NO2(-) concentrations in hypoxic and anoxic sediment layers in which significant NO3(-) consumption took place.	Nitrogen Dioxide	59-62	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
11927648-7	2002	Upon stimulation with antigen, IFN-gamma, or anti-CD8, nitrite production was increased significantly (8.4+/-0.6, 7.6+/-0.9, and 6.6+/-0.9 microM/2x10(5) cells/48 h NO2-, respectively; P<0.01), whereas unstimulated PMC released 2.1 +/- 0.3 microM/2 x 10(5) cells/48 h NO2-.	Nitrogen Dioxide	165-168	interferon gamma	Rattus norvegicus	31-40
12046987-0	2002	Effects of angiotensin II on the renal interstitial concentrations of NO2/NO3 and cyclic GMP in anesthetized rats.	Nitrogen Dioxide	70-73	angiotensinogen	Rattus norvegicus	11-25
12046987-1	2002	The present study was conducted to determine whether exogenous angiotensin II (Ang II) may increase the renal interstitial fluid concentrations of NO2/NO3 (NOx) and cyclic guanosine monophosphate (cGMP) concomitantly and which Ang II receptor subtypes may induce these changes in anesthetized rats, using a microdialysis method.	Nitrogen Dioxide	147-150	angiotensinogen	Rattus norvegicus	63-77
12046987-1	2002	The present study was conducted to determine whether exogenous angiotensin II (Ang II) may increase the renal interstitial fluid concentrations of NO2/NO3 (NOx) and cyclic guanosine monophosphate (cGMP) concomitantly and which Ang II receptor subtypes may induce these changes in anesthetized rats, using a microdialysis method.	Nitrogen Dioxide	147-150	angiotensinogen	Rattus norvegicus	79-85
12037614-4	2002	Two modes of NO3(-) supply to the sediments were compared: In treatments with NO3(-) supply to the overlying water, a subsurface maximum of NO2(-) concentration was observed, coinciding with the site of maximum NO3(-) consumption.	Nitrogen Dioxide	140-143	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
12037614-4	2002	Two modes of NO3(-) supply to the sediments were compared: In treatments with NO3(-) supply to the overlying water, a subsurface maximum of NO2(-) concentration was observed, coinciding with the site of maximum NO3(-) consumption.	Nitrogen Dioxide	140-143	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
12037614-5	2002	When NO3(-) was perfused up through the sediment cores, however, NO2(-) accumulated throughout the entire sediment column.	Nitrogen Dioxide	65-71	NBL1, DAN family BMP antagonist	Homo sapiens	5-8
11807393-1	2002	Peroxynitrite is responsible for nitration in vivo, whereas myeloperoxidase can also catalyze protein nitration in the presence of high NO2(-) levels.	Nitrogen Dioxide	136-139	myeloperoxidase	Mus musculus	60-75
11802212-5	2002	PRL-induced killing of P815 target cells by EMs and TAMs was independent of TNF but correlated with the hormone-induced augmentation of NO2(-) and O2(-) release in these macrophages.	Nitrogen Dioxide	136-139	prolactin	Mus musculus	0-3
11802212-6	2002	Administration of PRL in vivo inhibited EAC growth and augmented NO2(-) release by TAMs.	Nitrogen Dioxide	65-68	prolactin	Mus musculus	18-21
11802212-7	2002	PRL synergized with the TH1 cytokine IFN-gamma, a known activator of macrophages, in inducing tumor killing and release of NO2(-) from EMs and TAMs.	Nitrogen Dioxide	123-126	prolactin	Mus musculus	0-3
11802212-7	2002	PRL synergized with the TH1 cytokine IFN-gamma, a known activator of macrophages, in inducing tumor killing and release of NO2(-) from EMs and TAMs.	Nitrogen Dioxide	123-126	negative elongation factor complex member C/D, Th1l	Mus musculus	24-27
11802212-7	2002	PRL synergized with the TH1 cytokine IFN-gamma, a known activator of macrophages, in inducing tumor killing and release of NO2(-) from EMs and TAMs.	Nitrogen Dioxide	123-126	interferon gamma	Mus musculus	37-46
12638751-14	2002	In addition, the initial uptake coefficient for NO2 on fresh hexane soot was determined to be gamma0,BET = 1.7 +/- 1.1 x 10(-4).	Nitrogen Dioxide	48-51	delta/notch like EGF repeat containing	Homo sapiens	101-104
11714562-11	2001	Excessive CSF NO2-+NO3- levels being more increased than the levels in sera supports pathological inflammatory process within CNS (central nervous system) in both stages of MS. Another implication for the role of NO and INOS inhibitors in the treatment of MS patients with both RR and SP courses was also suggested.	Nitrogen Dioxide	14-17	nitric oxide synthase 2	Homo sapiens	220-224
12449607-2	2002	NO2- [symbol: see text] NO3- concentration was measured with Griss reagent and brucine reagent respectively with using the spectrophotometric method.	Nitrogen Dioxide	0-3	NBL1, DAN family BMP antagonist	Homo sapiens	24-27
12449607-3	2002	We first found that highlanders compared to lowlanders have increased blood level of NO2- (37 +/- 3.3 nmol/ml vs. 28.5 +/- 1.3 nmol/ml, P < 0.05) and NO3- (1362 +/- 43 nmol/ml vs. 845 +/- 65 nmol/ml, P < 0.001).	Nitrogen Dioxide	85-88	NBL1, DAN family BMP antagonist	Homo sapiens	153-156
12449607-4	2002	As the most significant, there was increase in NO2- concentration in erythrocytes (by about 6 times), NO3- level in erythrocytes was revealed to be increased by 2.5 times, whereas the plasma concentration of these stable metabolites was the same (for NO3-) or even slightly decreased (for NO2-).	Nitrogen Dioxide	289-292	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
11722903-6	2001	On addition of NO3(-) and NO2(-), Thioploca spp.	Nitrogen Dioxide	26-29	histocompatibility minor 13	Homo sapiens	44-47
11748259-1	2001	Nitrotyrosine formation is a hallmark of vascular inflammation, with polymorphonuclear neutrophil-derived (PMN-derived) and monocyte-derived myeloperoxidase (MPO) being shown to catalyze this posttranslational protein modification via oxidation of nitrite (NO(2)(-)) to nitrogen dioxide (NO(2)(*)).	Nitrogen Dioxide	270-286	myeloperoxidase	Mus musculus	141-156
11811525-8	2001	The generation of nitrite (NO2-) and nitrate (NO3-) by the NaN3/catalase/H2O2 system was maximal at pH 5.0.	Nitrogen Dioxide	27-30	catalase	Homo sapiens	64-72
11748259-1	2001	Nitrotyrosine formation is a hallmark of vascular inflammation, with polymorphonuclear neutrophil-derived (PMN-derived) and monocyte-derived myeloperoxidase (MPO) being shown to catalyze this posttranslational protein modification via oxidation of nitrite (NO(2)(-)) to nitrogen dioxide (NO(2)(*)).	Nitrogen Dioxide	270-286	myeloperoxidase	Mus musculus	158-161
12805838-9	2001	In 1988-1990 the estimated yearly total emission of NOx (as NO2 equivalent) was about 18 to 18.6 thousand t and in 1994-2000, 9.9 to 11.8 thousand t.	Nitrogen Dioxide	60-63	NADPH oxidase	Drosophila melanogaster	52-55
11602386-8	2001	Usual values were determined from healthy fasted subjects: the mean concentration of NO2- and NO3- was 47.8 muM +/- 15.7 muM (n = 25).	Nitrogen Dioxide	85-88	latexin	Homo sapiens	108-111
11602386-8	2001	Usual values were determined from healthy fasted subjects: the mean concentration of NO2- and NO3- was 47.8 muM +/- 15.7 muM (n = 25).	Nitrogen Dioxide	85-88	latexin	Homo sapiens	121-124
11572680-0	2001	Chemistry of NO2 on oxide surfaces: formation of NO3 on TiO2(110) and NO2<-->O vacancy interactions.	Nitrogen Dioxide	13-16	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
11389723-1	2001	The reactions of lactoperoxidase (LPO) intermediates compound I, compound II and compound III, with nitrite (NO2(-)) were investigated.	Nitrogen Dioxide	109-112	lactoperoxidase	Homo sapiens	17-32
11485379-4	2001	Acetoxime was oxidized to NO2- (and NO3-) by microsomes enriched with several P450 isoforms, including CYP2E1, CYP1A1, and CYP2B1.	Nitrogen Dioxide	26-29	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	78-82
11485379-4	2001	Acetoxime was oxidized to NO2- (and NO3-) by microsomes enriched with several P450 isoforms, including CYP2E1, CYP1A1, and CYP2B1.	Nitrogen Dioxide	26-29	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	103-109
11485379-4	2001	Acetoxime was oxidized to NO2- (and NO3-) by microsomes enriched with several P450 isoforms, including CYP2E1, CYP1A1, and CYP2B1.	Nitrogen Dioxide	26-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	111-117
11763539-3	2001	Concentration of NO3-/NO2- in the blood serum was elevated after stress.	Nitrogen Dioxide	22-25	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
11498801-8	2001	These results indicate that MT, MIP-2, and MCP-1 mRNA levels responded similarly to recovery from nitrogen dioxide, oxygen, and ozone exposure.	Nitrogen Dioxide	98-114	chemokine (C-C motif) ligand 2	Mus musculus	43-48
11389723-1	2001	The reactions of lactoperoxidase (LPO) intermediates compound I, compound II and compound III, with nitrite (NO2(-)) were investigated.	Nitrogen Dioxide	109-112	lactoperoxidase	Homo sapiens	34-37
11284446-3	2001	There were no significant changes in the plasma levels of NO2-/NO3-levels over time following treatment with TNF-alpha, but there was a significant increase (approximately twofold) in the activity of the iNOS in the lungs of animals treated with TNF-alpha.	Nitrogen Dioxide	58-61	tumor necrosis factor	Rattus norvegicus	246-255
11324986-5	2001	Once induced, iNOS will produce large amounts of NO for long periods of time, so that NO is converted into NO2, nitrite, peroxynitrite and free radicals to induce pathophysiological actions, such as optic nerve degeneration and posterior retinal degeneration lesion, which lead to glaucoma, retinopathy, age-related macular degeneration (AMD), myopia, cataracts and uveitis.	Nitrogen Dioxide	107-110	nitric oxide synthase 2	Homo sapiens	14-18
11452508-4	2001	Serum NO2- level had a positive correlation with CPK in male patients, but not in female and all Yusho patients.	Nitrogen Dioxide	6-9	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	49-52
11258973-8	2001	The rate constant of 8-oxo-dG oxidation (k(12)) by the (*)NO2 one-electron oxidant (the (*)NO2/NO2(-) redox potential, E degrees approximately 1.04 V vs NHE) is lower than k(12) for a series of oxidizing aromatic radical cations with known redox potentials.	Nitrogen Dioxide	58-61	solute carrier family 9 member C1	Homo sapiens	153-156
11229466-9	2001	In the same way, the amino sugar reduced NO2- and PGE2 production induced by IL-1beta.	Nitrogen Dioxide	41-44	interleukin 1 beta	Rattus norvegicus	77-85
11258973-8	2001	The rate constant of 8-oxo-dG oxidation (k(12)) by the (*)NO2 one-electron oxidant (the (*)NO2/NO2(-) redox potential, E degrees approximately 1.04 V vs NHE) is lower than k(12) for a series of oxidizing aromatic radical cations with known redox potentials.	Nitrogen Dioxide	91-94	solute carrier family 9 member C1	Homo sapiens	153-156
11258973-8	2001	The rate constant of 8-oxo-dG oxidation (k(12)) by the (*)NO2 one-electron oxidant (the (*)NO2/NO2(-) redox potential, E degrees approximately 1.04 V vs NHE) is lower than k(12) for a series of oxidizing aromatic radical cations with known redox potentials.	Nitrogen Dioxide	91-94	solute carrier family 9 member C1	Homo sapiens	153-156
11174195-2	2001	OBJECTIVE: We aimed to investigate the effects of O3 and NO2 on the release of IL-8, GM-CSF, RANTES, and soluble intercellular adhesion molecule 1 (sICAM-1) from human bronchial epithelial cells (HBECs) of nonatopic nonasthmatic subjects (nonasthmatic subjects) and atopic subjects with mild asthma (asthmatic subjects) in vitro.	Nitrogen Dioxide	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
11174195-6	2001	Exposure of HBECs of asthmatic subjects to both 50 to 100 ppb O3 and 200 to 400 ppb NO2 significantly increased the release of IL-8, GM-CSF, RANTES, and sICAM-1 from these cells after 24 hours of incubation.	Nitrogen Dioxide	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
11174195-6	2001	Exposure of HBECs of asthmatic subjects to both 50 to 100 ppb O3 and 200 to 400 ppb NO2 significantly increased the release of IL-8, GM-CSF, RANTES, and sICAM-1 from these cells after 24 hours of incubation.	Nitrogen Dioxide	84-87	colony stimulating factor 2	Homo sapiens	133-139
11174195-6	2001	Exposure of HBECs of asthmatic subjects to both 50 to 100 ppb O3 and 200 to 400 ppb NO2 significantly increased the release of IL-8, GM-CSF, RANTES, and sICAM-1 from these cells after 24 hours of incubation.	Nitrogen Dioxide	84-87	C-C motif chemokine ligand 5	Homo sapiens	141-147
11054430-2	2001	Recent studies have shown that myeloperoxidase (MPO), an abundant heme protein released by activated leukocytes, can oxidize nitrite (NO(2-)) to a radical species, most likely nitrogen dioxide.	Nitrogen Dioxide	176-192	myeloperoxidase	Homo sapiens	31-46
11054430-2	2001	Recent studies have shown that myeloperoxidase (MPO), an abundant heme protein released by activated leukocytes, can oxidize nitrite (NO(2-)) to a radical species, most likely nitrogen dioxide.	Nitrogen Dioxide	176-192	myeloperoxidase	Homo sapiens	48-51
11165887-8	2001	Supernatant NO2- in response to stimulation with lipopolysaccharide and interferon-gamma was determined by the Greiss reaction.	Nitrogen Dioxide	12-15	interferon gamma	Mus musculus	72-88
11215047-2	2000	NO3- was restored by using cadmium column assay and NO2- measured by heavy nitrogen assay.	Nitrogen Dioxide	52-55	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
11218888-3	2000	RESULTS: The expression of neutrophil CD11b was significantly elevated in women with preeclampsia compared with that of normal pregnant women at third trimester [the mean fluorescence index of CD11b were 439.1 +/- 169.1 and 321.2 +/- 166.3 respectively, P < 0.05], the plasma ET-1 level and serum NO2- concentration in preeclampsic women [(61.4 +/- 48.2) ng/L and (20.4 +/- 5.2) mumol/L, respectively] were both significantly increased compared with those in the normal pregnancy women [(29.3 +/- 20.9) ng/L and (15.5 +/- 4.8) mumol/L, respectively], (P < 0.01).	Nitrogen Dioxide	300-303	integrin subunit alpha M	Homo sapiens	38-43
11218888-4	2000	The mean fluorescence index of CD11b was significantly correlated with plasma ET-1 level and serum NO2- concentration (r = 0.312 and 0.382, respectively, P < 0.05).	Nitrogen Dioxide	99-102	integrin subunit alpha M	Homo sapiens	31-36
10946826-0	2000	rIL-2-stimulated splenocytes reactivate the NO2-producing ability of macrophages infected by Leishmania donovani.	Nitrogen Dioxide	44-47	interleukin 2	Rattus norvegicus	0-5
10946826-2	2000	Treatment with IL-2-stimulated-splenocytes activate parasiticidal action in vitro in peritoneal macrophages of C57BL/6 (Lsh(s)) mice and also was effective in stimulating infected macrophages to produce NO2-.	Nitrogen Dioxide	203-207	interleukin 2	Mus musculus	15-19
11002389-4	2000	NO2 exposure resulted in significantly increased pulmonary activities of G6PDH, GR, and GSHPx, both expressed per lung and per gram of lung weight.	Nitrogen Dioxide	0-3	glucose-6-phosphate dehydrogenase	Rattus norvegicus	73-78
11002389-4	2000	NO2 exposure resulted in significantly increased pulmonary activities of G6PDH, GR, and GSHPx, both expressed per lung and per gram of lung weight.	Nitrogen Dioxide	0-3	glutathione-disulfide reductase	Rattus norvegicus	80-82
11002389-4	2000	NO2 exposure resulted in significantly increased pulmonary activities of G6PDH, GR, and GSHPx, both expressed per lung and per gram of lung weight.	Nitrogen Dioxide	0-3	glutathione peroxidase 1	Rattus norvegicus	88-93
11002389-10	2000	NO2 exposure caused increases in the activities of G6PDH and GSHPx in isolated type II cells and of GSHPx in isolated macrophages, when expressed per number of cells.	Nitrogen Dioxide	0-3	glucose-6-phosphate dehydrogenase	Rattus norvegicus	51-56
11002389-10	2000	NO2 exposure caused increases in the activities of G6PDH and GSHPx in isolated type II cells and of GSHPx in isolated macrophages, when expressed per number of cells.	Nitrogen Dioxide	0-3	glutathione peroxidase 1	Rattus norvegicus	61-66
11002389-10	2000	NO2 exposure caused increases in the activities of G6PDH and GSHPx in isolated type II cells and of GSHPx in isolated macrophages, when expressed per number of cells.	Nitrogen Dioxide	0-3	glutathione peroxidase 1	Rattus norvegicus	100-105
10768942-6	2000	Activation by IFN-gamma also enhanced Mphi nitric oxide production, as revealed by increasing NO(2) values (8 +/- 3 microM in nonactivated Mphis versus 43 +/- 13 microM in activated Mphis).	Nitrogen Dioxide	94-99	interferon gamma	Mus musculus	14-23
12212263-0	2000	[Derivative-ratio derivative spectrum method for determining nitrate and nitrite radicals (NO3- and NO2-) in environmental water].	Nitrogen Dioxide	73-89	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
18475936-0	2000	Synthesis, Characterization and Biological Properties of Anions of Bivalent Transition Metal [Co(II) and Ni(II)] Complexes With Acylhydrazine Derived ONO Donor Schiff Bases.	Nitrogen Dioxide	150-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
18475936-1	2000	Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions.	Nitrogen Dioxide	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
11756889-7	2001	Nitrate (NO3) was 49.8 +/- 5.0 micromol/L in patients with PDR and 24.2 +/- 2.8 micromol/L in patients with macula hole; it was also significantly elevated in patients with PDR (P = 0.004, Mann-Whitney), whereas nitrite (NO2) was not detected in this study.	Nitrogen Dioxide	221-224	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
11103793-4	2000	After monoculture, treatment of RAW 264.7 cells with IFN-gamma for 24 h generated a large amount of nitrite (NO2-), as reported previously, whereas no increase in NO2- concentration was observed in the IFN-gamma-treated P+ or P-subclones.	Nitrogen Dioxide	109-112	interferon gamma	Mus musculus	53-62
11103793-5	2000	Interestingly, when IFN-gamma-treated RAW 264.7 cells were cocultured with P+ but not P- cells, we observed a marked increase in NO2- concentration (30.8+/-3.6 microM), which significantly exceeded (P < 0.01) the sum of the concentrations (20.0+/-2.3 microM) added from each cell line monoculture.	Nitrogen Dioxide	129-132	interferon gamma	Mus musculus	20-29
11103793-8	2000	The addition of IFN-gamma-treated RAW 264.7 cell-conditioned media to P+ subclones led to a significant enhancement of NO2- formation that was diminished by the TNF-alpha-specific but not IL-1beta-specific antibody.	Nitrogen Dioxide	119-122	interferon gamma	Mus musculus	16-25
11103793-8	2000	The addition of IFN-gamma-treated RAW 264.7 cell-conditioned media to P+ subclones led to a significant enhancement of NO2- formation that was diminished by the TNF-alpha-specific but not IL-1beta-specific antibody.	Nitrogen Dioxide	119-122	tumor necrosis factor	Mus musculus	161-170
11103793-9	2000	When combined with IFN-gamma, the recombinant TNF-alpha (1-100 ng/ml) enhanced NO2- formation in JB6 P+ cells, whereas IL-1beta (1-100 ng/ml) did not.	Nitrogen Dioxide	79-82	interferon gamma	Homo sapiens	19-28
11103793-9	2000	When combined with IFN-gamma, the recombinant TNF-alpha (1-100 ng/ml) enhanced NO2- formation in JB6 P+ cells, whereas IL-1beta (1-100 ng/ml) did not.	Nitrogen Dioxide	79-82	tumor necrosis factor	Homo sapiens	46-55
11098975-13	2000	iNOS+/+ mice subjected to SMAO had increased plasma concentrations of nitrite (NO2-) and nitrate (NO3-), and the plasma concentrations of NO2- and NO3- were highest in the mice in which bacterial translocation had occurred.	Nitrogen Dioxide	79-82	nitric oxide synthase 2, inducible	Mus musculus	0-4
11016861-4	2000	NO2- production stimulated by IL-1beta + TGFalpha was significantly reduced by N(G)-nitro-L-arginine methyl ester (L-NAME) or aminoguanidine, yet not by D-NAME.	Nitrogen Dioxide	0-3	interleukin 1 beta	Rattus norvegicus	30-38
11016861-4	2000	NO2- production stimulated by IL-1beta + TGFalpha was significantly reduced by N(G)-nitro-L-arginine methyl ester (L-NAME) or aminoguanidine, yet not by D-NAME.	Nitrogen Dioxide	0-3	transforming growth factor alpha	Rattus norvegicus	41-49
10993169-1	2000	During a photo-induced catalytic reaction under near UV irradiation to an aqueous suspension of Ti4O2, about 95% of NO2- was oxidized to NO3-, but NH4+ was not detected.	Nitrogen Dioxide	116-119	NBL1, DAN family BMP antagonist	Homo sapiens	137-140
10968413-11	2000	As a result of nitric oxide release, oxidation products of NO (NO2- and NO3-; NOx) in arterial blood rose following administration of NCX 4016.	Nitrogen Dioxide	63-66	T cell leukemia homeobox 2	Homo sapiens	134-137
10894808-3	2000	Myeloperoxidase generates a number of reactive species, including hypochlorous acid, chloramines, tyrosyl radicals, and nitrogen dioxide.	Nitrogen Dioxide	120-136	myeloperoxidase	Homo sapiens	0-15
10774828-0	2000	Quantitation and localization of pulmonary manganese superoxide dismutase and tumor necrosis factor alpha following exposure to ozone and nitrogen dioxide.	Nitrogen Dioxide	138-154	superoxide dismutase 2	Rattus norvegicus	43-73
10715624-9	2000	Monocyte chemoattractant protein (MCP-1) was elevated following 15 ppm NO(2) exposure.	Nitrogen Dioxide	71-76	chemokine (C-C motif) ligand 2	Mus musculus	34-39
10767762-2	2000	The detection of abundant NO+ and NO2- ions for HMX, RDX and CL-20, which are efficient matrices, indicates that explosive decomposition takes place in PDMS of these three substances and that a contribution from the corresponding chemical energy release is possible.	Nitrogen Dioxide	34-37	radixin	Homo sapiens	53-56
10767762-2	2000	The detection of abundant NO+ and NO2- ions for HMX, RDX and CL-20, which are efficient matrices, indicates that explosive decomposition takes place in PDMS of these three substances and that a contribution from the corresponding chemical energy release is possible.	Nitrogen Dioxide	34-37	epithelial membrane protein 1	Homo sapiens	61-66
10665407-7	2000	Agreement between the rate constants obtained experimentally and those calculated mechanistically supports the hypothesis that NO2- was oxidized to NO2 by .OH radicals from photolysis of FeOH2+ complexes, and at high [NO2-]0 (e.g., 80 microns) relative to [Fe(III)]0, hydrolysis of NO2 or N2O4 to form NO3- and NO2- could be significant.	Nitrogen Dioxide	127-130	NBL1, DAN family BMP antagonist	Homo sapiens	302-305
10665407-7	2000	Agreement between the rate constants obtained experimentally and those calculated mechanistically supports the hypothesis that NO2- was oxidized to NO2 by .OH radicals from photolysis of FeOH2+ complexes, and at high [NO2-]0 (e.g., 80 microns) relative to [Fe(III)]0, hydrolysis of NO2 or N2O4 to form NO3- and NO2- could be significant.	Nitrogen Dioxide	148-151	NBL1, DAN family BMP antagonist	Homo sapiens	302-305
10665407-7	2000	Agreement between the rate constants obtained experimentally and those calculated mechanistically supports the hypothesis that NO2- was oxidized to NO2 by .OH radicals from photolysis of FeOH2+ complexes, and at high [NO2-]0 (e.g., 80 microns) relative to [Fe(III)]0, hydrolysis of NO2 or N2O4 to form NO3- and NO2- could be significant.	Nitrogen Dioxide	148-151	NBL1, DAN family BMP antagonist	Homo sapiens	302-305
10665407-7	2000	Agreement between the rate constants obtained experimentally and those calculated mechanistically supports the hypothesis that NO2- was oxidized to NO2 by .OH radicals from photolysis of FeOH2+ complexes, and at high [NO2-]0 (e.g., 80 microns) relative to [Fe(III)]0, hydrolysis of NO2 or N2O4 to form NO3- and NO2- could be significant.	Nitrogen Dioxide	148-151	NBL1, DAN family BMP antagonist	Homo sapiens	302-305
10665407-7	2000	Agreement between the rate constants obtained experimentally and those calculated mechanistically supports the hypothesis that NO2- was oxidized to NO2 by .OH radicals from photolysis of FeOH2+ complexes, and at high [NO2-]0 (e.g., 80 microns) relative to [Fe(III)]0, hydrolysis of NO2 or N2O4 to form NO3- and NO2- could be significant.	Nitrogen Dioxide	148-151	NBL1, DAN family BMP antagonist	Homo sapiens	302-305
10647067-4	2000	High ET-1 levels induced a 20% decrease of NO2-/NO3- levels and cGMP intracellular content, followed by a 49% reduction of GK activity and a 15% decrease of glycogen.	Nitrogen Dioxide	43-46	endothelin 1	Rattus norvegicus	5-9
10609956-9	1999	Macrophage effector function was reduced in IL-10/Fc-treated mice, with a reduced macrophage infiltrate, reduced IL-12 and tumor necrosis factor-alpha gene expression and reduced serum NO2- levels.	Nitrogen Dioxide	185-188	interleukin 10	Mus musculus	44-49
12548860-3	1999	In the 2# clone expressing iNOS gene, iNOS catalytic activity in the cytosol fraction displayed to have an increasing trend, accompanying with the accumulation of NO2- content in the supernantant of cultured cells and the intracellular cGMP concentration, which suggested that NO-cGMP signal pathway was mediated by the expression of iNOS gene and blocked by NG-nitro-L-arginine (L-NNA) and methylene blue (MB).	Nitrogen Dioxide	163-166	nitric oxide synthase 2, inducible	Mus musculus	27-31
10616218-8	1999	L-Nitro-arginine-methylester (L-NAME), a competitive NOS-inhibitor, and iNOS antisense oligonucleotides effectively prevented NO2 generation and apoptosis.	Nitrogen Dioxide	126-129	nitric oxide synthase 2	Homo sapiens	72-76
12548860-3	1999	In the 2# clone expressing iNOS gene, iNOS catalytic activity in the cytosol fraction displayed to have an increasing trend, accompanying with the accumulation of NO2- content in the supernantant of cultured cells and the intracellular cGMP concentration, which suggested that NO-cGMP signal pathway was mediated by the expression of iNOS gene and blocked by NG-nitro-L-arginine (L-NNA) and methylene blue (MB).	Nitrogen Dioxide	163-166	nitric oxide synthase 2, inducible	Mus musculus	38-42
12548860-3	1999	In the 2# clone expressing iNOS gene, iNOS catalytic activity in the cytosol fraction displayed to have an increasing trend, accompanying with the accumulation of NO2- content in the supernantant of cultured cells and the intracellular cGMP concentration, which suggested that NO-cGMP signal pathway was mediated by the expression of iNOS gene and blocked by NG-nitro-L-arginine (L-NNA) and methylene blue (MB).	Nitrogen Dioxide	163-166	nitric oxide synthase 2, inducible	Mus musculus	38-42
10518791-8	1999	However, nitrosation reactions by N2O3 occurred only when the initial concentration of.NO2 was 10 times that able to react with angiotensin II.	Nitrogen Dioxide	87-90	angiotensinogen	Homo sapiens	128-142
10518791-5	1999	Angiotensin II is specifically nitrated at its tyrosinyl residue by.NO2 or peroxynitrite.	Nitrogen Dioxide	68-71	angiotensinogen	Homo sapiens	0-14
10497178-2	1999	We examined the effect of bicarbonate on the peroxidase activity of copper-zinc superoxide dismutase (SOD1), using the nitrite anion as a peroxidase probe.	Nitrogen Dioxide	119-132	superoxide dismutase 1	Homo sapiens	102-106
10574472-9	1999	As a consequence of down-regulation of iNOS and GTP-CH I genes, almost 3-fold diminished generation of NO2- by rat macrophages was observed.	Nitrogen Dioxide	103-106	nitric oxide synthase 2	Rattus norvegicus	39-43
10446104-3	1999	METHODS: iNOS activity was assessed by measuring the NO stable oxidative product NO(2)(-).	Nitrogen Dioxide	81-86	nitric oxide synthase 2	Homo sapiens	9-13
10574472-9	1999	As a consequence of down-regulation of iNOS and GTP-CH I genes, almost 3-fold diminished generation of NO2- by rat macrophages was observed.	Nitrogen Dioxide	103-106	GTP cyclohydrolase 1	Rattus norvegicus	48-56
11776556-12	1999	A significant decrease in the concentration of sputum NO2-./NO3-.	Nitrogen Dioxide	54-57	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
10400845-6	1999	NO2 also significantly increased the release of IL-8 from a control value of 52.5 pg/microgram cellular protein to 81.9 pg/microgram cellular protein (P <.05), RANTES from a control value of 0.023 pg/microgram cellular protein to 0.062 pg/microgram cellular protein (P <.05), and sICAM-1 from a control value of 7.7 pg/microgram cellular protein to 16.3 pg/microgram cellular protein (P <.05).	Nitrogen Dioxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
10437781-3	1999	We found that myeloperoxidase, an H2O2-generating system and nitrite (NO2-) peroxidized LDL lipids.	Nitrogen Dioxide	70-73	myeloperoxidase	Homo sapiens	14-29
10400845-6	1999	NO2 also significantly increased the release of IL-8 from a control value of 52.5 pg/microgram cellular protein to 81.9 pg/microgram cellular protein (P <.05), RANTES from a control value of 0.023 pg/microgram cellular protein to 0.062 pg/microgram cellular protein (P <.05), and sICAM-1 from a control value of 7.7 pg/microgram cellular protein to 16.3 pg/microgram cellular protein (P <.05).	Nitrogen Dioxide	0-3	C-C motif chemokine ligand 5	Homo sapiens	163-169
10400845-8	1999	Incubation with 2.5 micromol/L loratadine also significantly attenuated the NO2-induced release of RANTES and sICAM-1, but not IL-8.	Nitrogen Dioxide	76-79	C-C motif chemokine ligand 5	Homo sapiens	99-105
10437653-5	1999	In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol.	Nitrogen Dioxide	453-456	colony stimulating factor 3	Homo sapiens	35-40
10437653-5	1999	In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol.	Nitrogen Dioxide	357-360	colony stimulating factor 3	Homo sapiens	35-40
10437653-5	1999	In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol.	Nitrogen Dioxide	453-456	interferon gamma	Homo sapiens	65-74
10437653-6	1999	This inhibitory effect of G-CSF was still present after a 48 h incubation period (G-CSF + IFN-gamma/LPS: 319.56 +/- 6.26 nmol NO2-/NO3-/mg cell protein; IFN-gamma/LPS: 489.20 +/- 27.15 nmol NO2-/NO3-/mg cell protein (P < 0.05), n = 8, respectively).	Nitrogen Dioxide	126-130	colony stimulating factor 3	Homo sapiens	26-31
10437653-5	1999	In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol.	Nitrogen Dioxide	357-360	interferon gamma	Homo sapiens	65-74
10437653-6	1999	This inhibitory effect of G-CSF was still present after a 48 h incubation period (G-CSF + IFN-gamma/LPS: 319.56 +/- 6.26 nmol NO2-/NO3-/mg cell protein; IFN-gamma/LPS: 489.20 +/- 27.15 nmol NO2-/NO3-/mg cell protein (P < 0.05), n = 8, respectively).	Nitrogen Dioxide	126-130	colony stimulating factor 3	Homo sapiens	82-87
10437653-6	1999	This inhibitory effect of G-CSF was still present after a 48 h incubation period (G-CSF + IFN-gamma/LPS: 319.56 +/- 6.26 nmol NO2-/NO3-/mg cell protein; IFN-gamma/LPS: 489.20 +/- 27.15 nmol NO2-/NO3-/mg cell protein (P < 0.05), n = 8, respectively).	Nitrogen Dioxide	126-130	interferon gamma	Homo sapiens	90-99
10437653-6	1999	This inhibitory effect of G-CSF was still present after a 48 h incubation period (G-CSF + IFN-gamma/LPS: 319.56 +/- 6.26 nmol NO2-/NO3-/mg cell protein; IFN-gamma/LPS: 489.20 +/- 27.15 nmol NO2-/NO3-/mg cell protein (P < 0.05), n = 8, respectively).	Nitrogen Dioxide	126-129	colony stimulating factor 3	Homo sapiens	26-31
10437653-6	1999	This inhibitory effect of G-CSF was still present after a 48 h incubation period (G-CSF + IFN-gamma/LPS: 319.56 +/- 6.26 nmol NO2-/NO3-/mg cell protein; IFN-gamma/LPS: 489.20 +/- 27.15 nmol NO2-/NO3-/mg cell protein (P < 0.05), n = 8, respectively).	Nitrogen Dioxide	126-129	colony stimulating factor 3	Homo sapiens	82-87
10437653-6	1999	This inhibitory effect of G-CSF was still present after a 48 h incubation period (G-CSF + IFN-gamma/LPS: 319.56 +/- 6.26 nmol NO2-/NO3-/mg cell protein; IFN-gamma/LPS: 489.20 +/- 27.15 nmol NO2-/NO3-/mg cell protein (P < 0.05), n = 8, respectively).	Nitrogen Dioxide	126-129	interferon gamma	Homo sapiens	90-99
10359564-3	1999	We now report that reactive nitrogen species generated by the MPO-H2O2-NO2- system of monocytes convert LDL into a form (NO2-LDL) that is avidly taken up and degraded by macrophages, leading to massive cholesterol deposition and foam cell formation, essential steps in lesion development.	Nitrogen Dioxide	71-74	myeloperoxidase	Homo sapiens	62-65
10359564-3	1999	We now report that reactive nitrogen species generated by the MPO-H2O2-NO2- system of monocytes convert LDL into a form (NO2-LDL) that is avidly taken up and degraded by macrophages, leading to massive cholesterol deposition and foam cell formation, essential steps in lesion development.	Nitrogen Dioxide	121-124	myeloperoxidase	Homo sapiens	62-65
10359564-4	1999	Incubation of LDL with isolated MPO, an H2O2-generating system, and nitrite (NO2-)-- a major end-product of NO metabolism--resulted in nitration of apolipoprotein B 100 tyrosyl residues and initiation of LDL lipid peroxidation.	Nitrogen Dioxide	77-80	apolipoprotein B	Homo sapiens	148-168
10086983-3	1999	In such rats, IL-1beta (10 microgram/kg) induced a biphasic pressor response, with a rise in the plasma concentration of NOx (NO2(-) and NO3(-): metabolites of NO) during the second phase.	Nitrogen Dioxide	126-129	interleukin 1 beta	Rattus norvegicus	14-22
10225145-10	1999	In contrast, administration of the same volume of insulin-free vehicle resulted in elevation of urinary NO2-/NO3- (P < 0.05).	Nitrogen Dioxide	104-107	insulin	Homo sapiens	50-57
11360609-6	1999	In endothelium culture supernatant with TNF-alpha group, synthesis of ET-1, NO2- and 6-ket-PGF1 alpha increased, expression of FN on the surface of endothelial cells decreased, white blood cells adhesion to endothelial cells increased.	Nitrogen Dioxide	76-79	tumor necrosis factor	Homo sapiens	40-49
11360610-8	1999	The plasma NO2-/NO3- concentration was (38.0 +/- 10.0) mumol/L in the PIH group, which was also lower than that in the control group [(56.0 +/- 14.0) mumol/L] (P < 0.01).	Nitrogen Dioxide	11-14	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	70-73
10029554-7	1999	However, it was independent of chloride ion and little affected by scavengers of hypochlorous acid, suggesting that the reactive agent is a nitrogen dioxide-like species that results from the one-electron oxidation of NO2- by myeloperoxidase.	Nitrogen Dioxide	140-156	myeloperoxidase	Homo sapiens	226-241
10218656-0	1999	Oxidation of biological electron donors and antioxidants by a reactive lactoperoxidase metabolite from nitrite (NO2-): an EPR and spin trapping study.	Nitrogen Dioxide	112-115	lactoperoxidase	Homo sapiens	71-86
10218656-1	1999	We report that a lactoperoxidase (LPO) metabolite derived from nitrite (NO2-) catalyses one-electron oxidation of biological electron donors and antioxidants such as NADH, NADPH, cysteine, glutathione, ascorbate, and Trolox C.	Nitrogen Dioxide	72-75	lactoperoxidase	Homo sapiens	17-32
10218656-1	1999	We report that a lactoperoxidase (LPO) metabolite derived from nitrite (NO2-) catalyses one-electron oxidation of biological electron donors and antioxidants such as NADH, NADPH, cysteine, glutathione, ascorbate, and Trolox C.	Nitrogen Dioxide	72-75	lactoperoxidase	Homo sapiens	34-37
10218656-5	1999	We propose that in the LPO/H2O2/NO2-/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical *NO2, which then reacts with the biological substrates more efficiently than does LPO/H2O2 alone.	Nitrogen Dioxide	32-35	lactoperoxidase	Homo sapiens	23-26
10218656-5	1999	We propose that in the LPO/H2O2/NO2-/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical *NO2, which then reacts with the biological substrates more efficiently than does LPO/H2O2 alone.	Nitrogen Dioxide	32-35	lactoperoxidase	Homo sapiens	148-151
10218656-5	1999	We propose that in the LPO/H2O2/NO2-/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical *NO2, which then reacts with the biological substrates more efficiently than does LPO/H2O2 alone.	Nitrogen Dioxide	32-35	lactoperoxidase	Homo sapiens	148-151
10218656-5	1999	We propose that in the LPO/H2O2/NO2-/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical *NO2, which then reacts with the biological substrates more efficiently than does LPO/H2O2 alone.	Nitrogen Dioxide	228-231	lactoperoxidase	Homo sapiens	23-26
10218656-5	1999	We propose that in the LPO/H2O2/NO2-/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical *NO2, which then reacts with the biological substrates more efficiently than does LPO/H2O2 alone.	Nitrogen Dioxide	228-231	lactoperoxidase	Homo sapiens	148-151
10218656-5	1999	We propose that in the LPO/H2O2/NO2-/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical *NO2, which then reacts with the biological substrates more efficiently than does LPO/H2O2 alone.	Nitrogen Dioxide	228-231	lactoperoxidase	Homo sapiens	148-151
10066641-8	1999	We observed an increased IL-1beta-, IL-6-, IL-8- and TNF-alpha-specific mRNA expression of particle or fibre exposed AM, which was decreased after an additional NO2 exposure.	Nitrogen Dioxide	161-164	interleukin 1 beta	Homo sapiens	25-33
10066641-8	1999	We observed an increased IL-1beta-, IL-6-, IL-8- and TNF-alpha-specific mRNA expression of particle or fibre exposed AM, which was decreased after an additional NO2 exposure.	Nitrogen Dioxide	161-164	interleukin 6	Homo sapiens	36-47
10066641-8	1999	We observed an increased IL-1beta-, IL-6-, IL-8- and TNF-alpha-specific mRNA expression of particle or fibre exposed AM, which was decreased after an additional NO2 exposure.	Nitrogen Dioxide	161-164	tumor necrosis factor	Homo sapiens	53-62
10066641-9	1999	Also the particle or fibre exposure induced significant increase in IL-1beta-, IL-6-, IL-8 and TNF-alpha-release of AM which was decreased after an additional NO2 exposure (p <0.031).	Nitrogen Dioxide	159-162	interleukin 1 beta	Homo sapiens	68-76
10066641-9	1999	Also the particle or fibre exposure induced significant increase in IL-1beta-, IL-6-, IL-8 and TNF-alpha-release of AM which was decreased after an additional NO2 exposure (p <0.031).	Nitrogen Dioxide	159-162	tumor necrosis factor	Homo sapiens	95-104
10029554-7	1999	However, it was independent of chloride ion and little affected by scavengers of hypochlorous acid, suggesting that the reactive agent is a nitrogen dioxide-like species that results from the one-electron oxidation of NO2- by myeloperoxidase.	Nitrogen Dioxide	218-221	myeloperoxidase	Homo sapiens	226-241
10029554-10	1999	The reaction required NO2- and was inhibited by catalase and heme poisons, implicating myeloperoxidase in the cell-mediated pathway.	Nitrogen Dioxide	22-25	myeloperoxidase	Homo sapiens	87-102
10029554-11	1999	These results indicate that human neutrophils use the myeloperoxidase-H2O2-NO2- system to generate reactive species that can nitrate the C-8 position of 2"-deoxyguanosine.	Nitrogen Dioxide	75-78	myeloperoxidase	Homo sapiens	54-69
10079961-5	1999	Elevation of NO2/NO3 was most pronounced 24 to 48 hr after trauma or ischemic stroke.	Nitrogen Dioxide	13-16	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
10051728-9	1999	RESULTS: Analysis of eosinophil cationic protein (ECP) in lavage samples from patients treated with placebo, demonstrated that this was significantly increased from a median value of 2.3 ng/mL (range: 1.0-7.1) to 15.1 ng/mL (range: 1.5-40.0; P = 0.001) following exposure to NO2 and allergen challenge.	Nitrogen Dioxide	275-278	ribonuclease A family member 3	Homo sapiens	21-48
10380161-7	1999	In the BL, NO2 exposure caused increases in polymorphonuclear neutrophils (PMNs), interleukin 6 (IL-6), IL-8, alpha1-antitrypsin, and tissue plasminogen activator, and decreases in epithelial cells.	Nitrogen Dioxide	11-14	interleukin 6	Homo sapiens	82-95
10380161-7	1999	In the BL, NO2 exposure caused increases in polymorphonuclear neutrophils (PMNs), interleukin 6 (IL-6), IL-8, alpha1-antitrypsin, and tissue plasminogen activator, and decreases in epithelial cells.	Nitrogen Dioxide	11-14	interleukin 6	Homo sapiens	97-101
10380161-7	1999	In the BL, NO2 exposure caused increases in polymorphonuclear neutrophils (PMNs), interleukin 6 (IL-6), IL-8, alpha1-antitrypsin, and tissue plasminogen activator, and decreases in epithelial cells.	Nitrogen Dioxide	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
10380161-7	1999	In the BL, NO2 exposure caused increases in polymorphonuclear neutrophils (PMNs), interleukin 6 (IL-6), IL-8, alpha1-antitrypsin, and tissue plasminogen activator, and decreases in epithelial cells.	Nitrogen Dioxide	11-14	serpin family A member 1	Homo sapiens	110-128
9789014-4	1998	The presence of NO2- also greatly enhanced alpha-tocopherol (alpha-TH) oxidation by SOD/H2O2 in saturated 1, 2-dilauroyl-sn-glycero-3-phosphatidylcholine liposomes.	Nitrogen Dioxide	16-19	superoxide dismutase 1	Homo sapiens	84-87
9872760-1	1999	Recent studies of major rivers in Northern Ireland have shown that high NO2- concentrations found in summer, under warm, slow-flowing conditions, arise from anaerobic NO3- reduction.	Nitrogen Dioxide	73-76	NBL1, DAN family BMP antagonist	Homo sapiens	168-171
27389509-7	1999	The best substrate for cathepsin D was Arg-Pro-Lys-Pro-Leu-Leu-Phe(NO2)-Tyr-Leu-Leu and its kcat/Km was 1.3 muM(-1) s(-1).	Nitrogen Dioxide	67-70	cathepsin D	Homo sapiens	23-34
9921279-6	1998	Thioglycollate-elicited macrophages co-cultured with noninfected YAC-1 cells showed low cytotoxic activity (34.7 +/- 8.6%) and low production of NO (4.7 +/- 3.1 microM NO2-).	Nitrogen Dioxide	168-171	ADP-ribosyltransferase 1	Mus musculus	65-70
9921279-7	1998	These macrophages co-cultured with mycoplasma-infected YAC-1 cells showed significantly higher cytotoxic activity (61.4 +/- 9.1%; P < 0.05) and higher NO production (48.5 +/- 13 microM NO2-; P < 0.05).	Nitrogen Dioxide	188-191	ADP-ribosyltransferase 1	Mus musculus	55-60
9789014-3	1998	We report in this study that lipid peroxidation of L-alpha-lecithin liposomes was enhanced greatly during the SOD/H2O2 reaction in the presence of nitrite anion (NO2-) with or without the metal ion chelator, diethylenetriaminepentacetic acid.	Nitrogen Dioxide	147-160	superoxide dismutase 1	Homo sapiens	110-113
9789014-3	1998	We report in this study that lipid peroxidation of L-alpha-lecithin liposomes was enhanced greatly during the SOD/H2O2 reaction in the presence of nitrite anion (NO2-) with or without the metal ion chelator, diethylenetriaminepentacetic acid.	Nitrogen Dioxide	162-165	superoxide dismutase 1	Homo sapiens	110-113
9789014-8	1998	NO2- inhibited H2O2-dependent inactivation of SOD.	Nitrogen Dioxide	0-3	superoxide dismutase 1	Homo sapiens	46-49
9789014-9	1998	A proposed mechanism of this protection involves the oxidation of NO2- by an SOD-bound oxidant to the nitrogen dioxide radical (*NO2).	Nitrogen Dioxide	66-69	superoxide dismutase 1	Homo sapiens	77-80
9789014-9	1998	A proposed mechanism of this protection involves the oxidation of NO2- by an SOD-bound oxidant to the nitrogen dioxide radical (*NO2).	Nitrogen Dioxide	129-132	superoxide dismutase 1	Homo sapiens	77-80
9861182-8	1998	Total mortality was significantly associated with a 10 micrograms/m3 increase in particles (0.4%) on that day (log 0), and with a 10 micrograms/m3 increase in NO2 at lag 1 (0.3%) and lag 2 (0.4%) (1 and 2 days before, respectively).	Nitrogen Dioxide	159-162	ceramide synthase 1	Homo sapiens	166-171
9758023-5	1998	RESULTS: For the first 24 hours of NO inhalation (6.3+/-1.1 ppm), NO3- plasma concentration increased (from 13.3+/-5.4 to 52.3+/-17.6 micromol/L), but NO2- plasma concentration was not affected.	Nitrogen Dioxide	151-154	NBL1, DAN family BMP antagonist	Homo sapiens	66-69
9788905-3	1998	Not surprisingly, living organisms have developed complex integrated extracellular and intracellular defense systems against stresses related to reactive oxygen and nitrogen species (ROS, RNS), including O3 and NO2.	Nitrogen Dioxide	211-214	FAM20C golgi associated secretory pathway kinase	Homo sapiens	188-191
9770329-3	1998	A linear correlation was observed between CD23 expression and iNOS activity or NO2- production.	Nitrogen Dioxide	79-82	Fc epsilon receptor II	Homo sapiens	42-46
9861182-9	1998	The effect of particles (lag 0) and of NO2 (lag 2) on total mortality was higher among those living in the city centre (0.7% and 0.5%, respectively).	Nitrogen Dioxide	39-42	granulysin	Homo sapiens	44-49
9712914-3	1998	Specific antibody-mediated aggregation of CD120a (p55) induced NO2- accumulation in culture supernatants and iNOS mRNA expression in macrophage lysates, whereas cross-linking of CD120b (p75) had a minimal effect.	Nitrogen Dioxide	63-66	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	42-48
9712914-3	1998	Specific antibody-mediated aggregation of CD120a (p55) induced NO2- accumulation in culture supernatants and iNOS mRNA expression in macrophage lysates, whereas cross-linking of CD120b (p75) had a minimal effect.	Nitrogen Dioxide	63-66	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	50-53
9712914-5	1998	Antibody-mediated blockade of CD120a (p55) completely inhibited NO2- expression in response to TNFalpha, whereas blockade of CD120b (p75) reduced NO2- accumulation by approximately 50%.	Nitrogen Dioxide	64-67	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	38-41
9729377-8	1998	Media accumulation of NO2- and PGE2 was inhibited by Tau-Cl in a concentration dependent manner and this was accompanied by decreased amounts of iNOS and COX-2 proteins in cell lysates.	Nitrogen Dioxide	22-25	nitric oxide synthase 2	Rattus norvegicus	145-149
9712914-5	1998	Antibody-mediated blockade of CD120a (p55) completely inhibited NO2- expression in response to TNFalpha, whereas blockade of CD120b (p75) reduced NO2- accumulation by approximately 50%.	Nitrogen Dioxide	64-67	tumor necrosis factor	Mus musculus	95-103
9729377-8	1998	Media accumulation of NO2- and PGE2 was inhibited by Tau-Cl in a concentration dependent manner and this was accompanied by decreased amounts of iNOS and COX-2 proteins in cell lysates.	Nitrogen Dioxide	22-25	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	154-159
9712914-6	1998	Specific ligation of CD120a (p55) with either (i) human TNFalpha or (ii) by incubation with mouse TNFalpha following pretreatment of macrophages with blocking concentrations of anti-CD120b (p75) antibody resulted in a similar reduction in NO2- production in response to TNFalpha.	Nitrogen Dioxide	239-242	TNF receptor superfamily member 1A	Homo sapiens	21-27
9712914-6	1998	Specific ligation of CD120a (p55) with either (i) human TNFalpha or (ii) by incubation with mouse TNFalpha following pretreatment of macrophages with blocking concentrations of anti-CD120b (p75) antibody resulted in a similar reduction in NO2- production in response to TNFalpha.	Nitrogen Dioxide	239-242	TNF receptor superfamily member 1A	Homo sapiens	29-32
9667498-0	1998	Lactoperoxidase-catalyzed oxidation of melanin by reactive nitrogen species derived from nitrite (NO2-): an EPR study.	Nitrogen Dioxide	98-102	lactoperoxidase	Homo sapiens	0-15
9705211-2	1998	We report that both myeloperoxidase (MPO) and horseradish peroxidase (HRP) utilize nitrite (NO2-) and hydrogen peroxide (H2O2) as substrates to catalyze tyrosine nitration in proteins.	Nitrogen Dioxide	92-96	myeloperoxidase	Rattus norvegicus	37-40
9705211-9	1998	In contrast, MPO catalyzed nitration of many proteins in rat heart homogenates using NO2- plus H2O2, suggesting that peroxidase-catalyzed nitration of tyrosine could occur in the presence of competing substrates in vivo.	Nitrogen Dioxide	85-88	myeloperoxidase	Rattus norvegicus	13-16
9698594-7	1998	Both types of asbestos fibers (chrysotile > crocidolite) upregulated the formation of NO2- in mesothelial cells costimulated with IL-1beta in a concentration-dependent and time-dependent fashion.	Nitrogen Dioxide	89-92	interleukin 1 beta	Rattus norvegicus	133-141
9675176-10	1998	The NO3-/NO2- ratio was predicted to vary exponentially with the ratio of O2- to NO release rates from the cells.	Nitrogen Dioxide	9-12	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
9708463-9	1998	Plasma NO3- was reduced to NO2- by nitrate reductase before determination of NO2- concentration by chemiluminescence.	Nitrogen Dioxide	27-30	NBL1, DAN family BMP antagonist	Homo sapiens	7-10
9708463-9	1998	Plasma NO3- was reduced to NO2- by nitrate reductase before determination of NO2- concentration by chemiluminescence.	Nitrogen Dioxide	77-80	NBL1, DAN family BMP antagonist	Homo sapiens	7-10
9721692-24	1998	to form NO2., dramatically potentiated the IL-1beta effect suggests that NO2.	Nitrogen Dioxide	8-11	interleukin 1 beta	Homo sapiens	43-51
9721692-24	1998	to form NO2., dramatically potentiated the IL-1beta effect suggests that NO2.	Nitrogen Dioxide	73-76	interleukin 1 beta	Homo sapiens	43-51
9865496-8	1998	Collectively, our data indicate that NO2- + NO3- levels correlate with IFN levels and immunoreactivity, and overall suggest that IFN-gamma and nitric oxide production together play a role in the host defense mechanisms in human hydatidosis.	Nitrogen Dioxide	37-40	interferon alpha 1	Homo sapiens	71-74
9865496-8	1998	Collectively, our data indicate that NO2- + NO3- levels correlate with IFN levels and immunoreactivity, and overall suggest that IFN-gamma and nitric oxide production together play a role in the host defense mechanisms in human hydatidosis.	Nitrogen Dioxide	37-40	interferon gamma	Homo sapiens	129-138
9686606-3	1998	We describe the effects of the interaction of NO and its decay product, NO2, with H2O2 and MPO on IC cross-linking.	Nitrogen Dioxide	72-75	myeloperoxidase	Homo sapiens	91-94
9686606-9	1998	These results indicated that the product of interaction of H2O2 and NO2 mediated by MPO may be responsible for the increase in cross-linking.	Nitrogen Dioxide	68-71	myeloperoxidase	Homo sapiens	84-87
10101929-6	1998	The concentration of NO2- was measured with the use of a calorimetric micromethod, where nitrate reductase catalyses the conversion of NO3- to NO2-.	Nitrogen Dioxide	21-24	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
10101929-6	1998	The concentration of NO2- was measured with the use of a calorimetric micromethod, where nitrate reductase catalyses the conversion of NO3- to NO2-.	Nitrogen Dioxide	143-146	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
9820648-9	1998	In order to investigate, whether NO2-exposure alters inducible NO-synthase mRNA expression, we now perform reverse transcription polymerase chain reaction (RT-PCR) of iNOS mRNA.	Nitrogen Dioxide	33-36	nitric oxide synthase 2	Bos taurus	167-171
9820648-10	1998	This method will be a good tool to elucidate whether NO2-exposure can modulate iNOS mRNA expression.	Nitrogen Dioxide	53-56	nitric oxide synthase 2	Bos taurus	79-83
9667498-6	1998	We propose that the mechanism for the generation of melanin radicals by the LPO/H2O2/nitrite system involves oxidation of NO2- by LPO/H2O2 to a reactive metabolite, most likely the nitrogen dioxide radical (.NO2), which subsequently reacts with melanin 5,6-dihydroxyindole subunits producing the respective semiquinone radicals.	Nitrogen Dioxide	122-125	lactoperoxidase	Homo sapiens	76-79
9667498-6	1998	We propose that the mechanism for the generation of melanin radicals by the LPO/H2O2/nitrite system involves oxidation of NO2- by LPO/H2O2 to a reactive metabolite, most likely the nitrogen dioxide radical (.NO2), which subsequently reacts with melanin 5,6-dihydroxyindole subunits producing the respective semiquinone radicals.	Nitrogen Dioxide	122-125	lactoperoxidase	Homo sapiens	130-133
9667498-6	1998	We propose that the mechanism for the generation of melanin radicals by the LPO/H2O2/nitrite system involves oxidation of NO2- by LPO/H2O2 to a reactive metabolite, most likely the nitrogen dioxide radical (.NO2), which subsequently reacts with melanin 5,6-dihydroxyindole subunits producing the respective semiquinone radicals.	Nitrogen Dioxide	208-211	lactoperoxidase	Homo sapiens	76-79
9667498-6	1998	We propose that the mechanism for the generation of melanin radicals by the LPO/H2O2/nitrite system involves oxidation of NO2- by LPO/H2O2 to a reactive metabolite, most likely the nitrogen dioxide radical (.NO2), which subsequently reacts with melanin 5,6-dihydroxyindole subunits producing the respective semiquinone radicals.	Nitrogen Dioxide	208-211	lactoperoxidase	Homo sapiens	130-133
10923512-8	1998	In severe PIH the umbilical venous blood NO2-/NO3- level was significantly lower than that in the normal term pregnancy group (P < 0.01).	Nitrogen Dioxide	41-44	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	10-13
9655731-2	1998	It is produced by nitric oxide synthase (NOS) and is rapidly metabolized to nitrite and nitrate (NO2/NO3).	Nitrogen Dioxide	97-100	nitric oxide synthase 2	Homo sapiens	18-39
9655731-2	1998	It is produced by nitric oxide synthase (NOS) and is rapidly metabolized to nitrite and nitrate (NO2/NO3).	Nitrogen Dioxide	97-100	NBL1, DAN family BMP antagonist	Homo sapiens	101-104
9721340-4	1998	As a result of nonenzymatic/enzymatic NO oxidation, NO2- and NO3- ions are formed: L-Arg --> NO --> NO2-/NO3-.	Nitrogen Dioxide	52-55	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
9721340-4	1998	As a result of nonenzymatic/enzymatic NO oxidation, NO2- and NO3- ions are formed: L-Arg --> NO --> NO2-/NO3-.	Nitrogen Dioxide	106-109	NBL1, DAN family BMP antagonist	Homo sapiens	61-64
9721340-6	1998	The reduction of NO2- ions to NO is realized by electron-donor systems with the participation of NADH, NADPH, flavoproteins, and cytochrome oxidase in mitochondria and by NADH, NADPH, flavoproteins, and cytochrome P-450 in endoplasmic reticulum.	Nitrogen Dioxide	17-20	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	203-219
10682461-8	1998	Compared with the normotensive group, maternal serum NO2-/NO3- in PIH group was significantly higher (P < 0.01), while significantly higher serum NO2-/NO3- were also found in umbilical venous blood in PIH group (P < 0.05).	Nitrogen Dioxide	53-56	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
9576800-3	1998	When NADPH was replaced with a glucose-6-phosphate dehydrogenase (G6PDH)-dependent NADPH-generating system, rates of NO2- reduction reached approximately 10 times that of the NADPH-dependent system.	Nitrogen Dioxide	118-121	uncharacterized protein	Chlamydomonas reinhardtii	32-65
9576800-3	1998	When NADPH was replaced with a glucose-6-phosphate dehydrogenase (G6PDH)-dependent NADPH-generating system, rates of NO2- reduction reached approximately 10 times that of the NADPH-dependent system.	Nitrogen Dioxide	118-121	uncharacterized protein	Chlamydomonas reinhardtii	67-72
9576800-4	1998	G6PDH could be replaced by either 6-phosphogluconate dehydrogenase or isocitrate dehydrogenase, indicating that G6PDH functioned to: (a) regenerate NADPH to support NO2- reduction and (b) consume NADP+, releasing FNR from NADP+ inhibition.	Nitrogen Dioxide	166-169	uncharacterized protein	Chlamydomonas reinhardtii	1-6
9576800-4	1998	G6PDH could be replaced by either 6-phosphogluconate dehydrogenase or isocitrate dehydrogenase, indicating that G6PDH functioned to: (a) regenerate NADPH to support NO2- reduction and (b) consume NADP+, releasing FNR from NADP+ inhibition.	Nitrogen Dioxide	166-169	uncharacterized protein	Chlamydomonas reinhardtii	113-118
9576800-6	1998	The rate of G6PDH-dependent NO2- reduction observed in vitro is capable of accounting for the observed rates of dark NO3- assimilation by C. reinhardtii.	Nitrogen Dioxide	29-32	uncharacterized protein	Chlamydomonas reinhardtii	13-18
9602105-3	1998	Intraperitoneally administered IL-1 beta produced a significant increase in both NO2- and NO3- levels in the PVN region.	Nitrogen Dioxide	81-84	interleukin 1 beta	Rattus norvegicus	31-40
9573545-4	1998	Compared to the control infusion, L-arginine did not significantly alter blood pressure, inulin or paraaminohippurate clearance, but significantly increased (P < 0.05) the excretion of NO2 + NO3 (NOx) (LS, 157 +/- 46 to 210 +/- 48 mumol.min-1; HS, 138 +/- 30 to 182 +/- 70) and cGMP (LS, 253 +/- 63 to 337 +/- 76 pmol.min-1; HS, 311 +/- 68 to 563 +/- 52).	Nitrogen Dioxide	188-193	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
10682461-8	1998	Compared with the normotensive group, maternal serum NO2-/NO3- in PIH group was significantly higher (P < 0.01), while significantly higher serum NO2-/NO3- were also found in umbilical venous blood in PIH group (P < 0.05).	Nitrogen Dioxide	53-56	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	66-69
9586818-11	1998	TNFalpha and LPS both increased NO2 in GPTE cells, but none of the Ca++-mobilizing agents nor p + XO significantly affected intracellular RNS.	Nitrogen Dioxide	32-35	tumor necrosis factor	Mus musculus	0-8
10681832-7	1998	After the AMs were stimulated with granulocyte-macrophage colony stimulating factor (GM-CSF), the level of NO2-/NO2- in the supernatants was significantly increased (P< 0.01); while the mRNA expression of AM iNOS from patients with lung cancer resulted in an increase of 16.85+/- 7.58% vs 33.38+/- 8.21% of control group (P< 0.05).	Nitrogen Dioxide	107-110	colony stimulating factor 2	Homo sapiens	35-83
9530263-7	1998	NO2- synthesis was inhibited by L-NMMA and IL-4.	Nitrogen Dioxide	0-3	interleukin 4	Rattus norvegicus	43-47
9450756-4	1998	We have recently demonstrated that nitrite (NO2-), a major end-product of .NO metabolism, readily promotes tyrosine nitration through formation of nitryl chloride (NO2Cl) and nitrogen dioxide (.NO2) by reaction with the inflammatory mediators hypochlorous acid (HOCl) or myeloperoxidase.	Nitrogen Dioxide	44-47	myeloperoxidase	Homo sapiens	271-286
9450756-4	1998	We have recently demonstrated that nitrite (NO2-), a major end-product of .NO metabolism, readily promotes tyrosine nitration through formation of nitryl chloride (NO2Cl) and nitrogen dioxide (.NO2) by reaction with the inflammatory mediators hypochlorous acid (HOCl) or myeloperoxidase.	Nitrogen Dioxide	175-191	myeloperoxidase	Homo sapiens	271-286
9450756-4	1998	We have recently demonstrated that nitrite (NO2-), a major end-product of .NO metabolism, readily promotes tyrosine nitration through formation of nitryl chloride (NO2Cl) and nitrogen dioxide (.NO2) by reaction with the inflammatory mediators hypochlorous acid (HOCl) or myeloperoxidase.	Nitrogen Dioxide	164-167	myeloperoxidase	Homo sapiens	271-286
9450756-5	1998	We now show that activated human polymorphonuclear neutrophils convert NO2- into NO2Cl and .NO2 through myeloperoxidase-dependent pathways.	Nitrogen Dioxide	71-74	myeloperoxidase	Homo sapiens	104-119
9450756-5	1998	We now show that activated human polymorphonuclear neutrophils convert NO2- into NO2Cl and .NO2 through myeloperoxidase-dependent pathways.	Nitrogen Dioxide	81-84	myeloperoxidase	Homo sapiens	104-119
9450756-8	1998	Polymorphonuclear neutrophil-mediated inactivation of endothelial cell angiotensin-converting enzyme was exacerbated by NO2-, illustrating the physiological significance of these reaction pathways to cellular dysfunction.	Nitrogen Dioxide	120-123	angiotensin I converting enzyme	Homo sapiens	71-100
9488173-3	1998	In addition, 4VO produced a gradual increase in hippocampal NO2- and NO3- levels over a 24 h period after reperfusion, which was abolished by an inducible NO synthase inhibitor, aminoguanidine (10 mg/kg, intraperitoneally).	Nitrogen Dioxide	60-63	nitric oxide synthase 2	Rattus norvegicus	145-166
9439595-6	1998	Inclusion of 1 mM NG-nitro-L-arginine methyl ester or 0.5 mM NG-monomethyl-L-arginine in the incubation abolished the increase in NO2- plus NO3- induced by the cytokine mixture and partially reversed the inhibitory effects on glucose mobilization in the presence of either insulin or glucagon, confirming the involvement of NO.	Nitrogen Dioxide	130-133	insulin	Homo sapiens	273-280
10681832-7	1998	After the AMs were stimulated with granulocyte-macrophage colony stimulating factor (GM-CSF), the level of NO2-/NO2- in the supernatants was significantly increased (P< 0.01); while the mRNA expression of AM iNOS from patients with lung cancer resulted in an increase of 16.85+/- 7.58% vs 33.38+/- 8.21% of control group (P< 0.05).	Nitrogen Dioxide	107-110	colony stimulating factor 2	Homo sapiens	85-91
10681832-7	1998	After the AMs were stimulated with granulocyte-macrophage colony stimulating factor (GM-CSF), the level of NO2-/NO2- in the supernatants was significantly increased (P< 0.01); while the mRNA expression of AM iNOS from patients with lung cancer resulted in an increase of 16.85+/- 7.58% vs 33.38+/- 8.21% of control group (P< 0.05).	Nitrogen Dioxide	107-110	nitric oxide synthase 2	Homo sapiens	211-215
10681832-7	1998	After the AMs were stimulated with granulocyte-macrophage colony stimulating factor (GM-CSF), the level of NO2-/NO2- in the supernatants was significantly increased (P< 0.01); while the mRNA expression of AM iNOS from patients with lung cancer resulted in an increase of 16.85+/- 7.58% vs 33.38+/- 8.21% of control group (P< 0.05).	Nitrogen Dioxide	112-115	colony stimulating factor 2	Homo sapiens	35-83
10681832-7	1998	After the AMs were stimulated with granulocyte-macrophage colony stimulating factor (GM-CSF), the level of NO2-/NO2- in the supernatants was significantly increased (P< 0.01); while the mRNA expression of AM iNOS from patients with lung cancer resulted in an increase of 16.85+/- 7.58% vs 33.38+/- 8.21% of control group (P< 0.05).	Nitrogen Dioxide	112-115	colony stimulating factor 2	Homo sapiens	85-91
9816580-8	1998	Stimulation T-cells line in the men exposed to NO2 and NO was evidenced by an increased number of T CD3+ cells, about two-fold increase in absolute number of T CD4+ cells (p < 0.001), an increased number of T CD8+ cells (p < 0.001) and by an enhanced value (by 24.7%) of the T CD4+/T CD8+ ratio.	Nitrogen Dioxide	47-50	CD4 molecule	Homo sapiens	160-163
9816580-8	1998	Stimulation T-cells line in the men exposed to NO2 and NO was evidenced by an increased number of T CD3+ cells, about two-fold increase in absolute number of T CD4+ cells (p < 0.001), an increased number of T CD8+ cells (p < 0.001) and by an enhanced value (by 24.7%) of the T CD4+/T CD8+ ratio.	Nitrogen Dioxide	47-50	CD8a molecule	Homo sapiens	212-215
9816580-8	1998	Stimulation T-cells line in the men exposed to NO2 and NO was evidenced by an increased number of T CD3+ cells, about two-fold increase in absolute number of T CD4+ cells (p < 0.001), an increased number of T CD8+ cells (p < 0.001) and by an enhanced value (by 24.7%) of the T CD4+/T CD8+ ratio.	Nitrogen Dioxide	47-50	CD4 molecule	Homo sapiens	283-286
9816580-8	1998	Stimulation T-cells line in the men exposed to NO2 and NO was evidenced by an increased number of T CD3+ cells, about two-fold increase in absolute number of T CD4+ cells (p < 0.001), an increased number of T CD8+ cells (p < 0.001) and by an enhanced value (by 24.7%) of the T CD4+/T CD8+ ratio.	Nitrogen Dioxide	47-50	CD8a molecule	Homo sapiens	290-293
9816580-10	1998	Stimulation T-cells line in the groups of 5 non-smoking workers exposed to NO2 and NO was evidenced by an increased number of T CD3+ (p < 0.05), T CD4+ (p < 0.05) and T CD8+ cells but without any change in the value of the T CD4+/T CD8+ ratio.	Nitrogen Dioxide	75-78	CD4 molecule	Homo sapiens	150-153
9816580-10	1998	Stimulation T-cells line in the groups of 5 non-smoking workers exposed to NO2 and NO was evidenced by an increased number of T CD3+ (p < 0.05), T CD4+ (p < 0.05) and T CD8+ cells but without any change in the value of the T CD4+/T CD8+ ratio.	Nitrogen Dioxide	75-78	CD8a molecule	Homo sapiens	175-178
9816580-10	1998	Stimulation T-cells line in the groups of 5 non-smoking workers exposed to NO2 and NO was evidenced by an increased number of T CD3+ (p < 0.05), T CD4+ (p < 0.05) and T CD8+ cells but without any change in the value of the T CD4+/T CD8+ ratio.	Nitrogen Dioxide	75-78	CD4 molecule	Homo sapiens	231-234
9816580-10	1998	Stimulation T-cells line in the groups of 5 non-smoking workers exposed to NO2 and NO was evidenced by an increased number of T CD3+ (p < 0.05), T CD4+ (p < 0.05) and T CD8+ cells but without any change in the value of the T CD4+/T CD8+ ratio.	Nitrogen Dioxide	75-78	CD8a molecule	Homo sapiens	238-241
9816580-12	1998	Moreover, significant positive correlations between NO2 concentrations in the air and the numbers of total lymphocytes, T CD3+, TCD4+, T CD8+ cells or IgG: (magnitude of r in the range between 0.31 and 0.71), as well as significant negative correlations between NO2 concentrations in the air and C3c (r = 0.44) in the group of 16 smoking and non-smoking workers were calculated.	Nitrogen Dioxide	52-55	CD8a molecule	Homo sapiens	137-140
9816580-15	1998	The results obtained suggest that during occupational exposure NO2 may play a more important role mainly in the process of inflammation but exogenous NO seems to act as modulating factor of this proinflammatory NO2 effect through a greater and exposure-dependent influence mainly on B CD19+ cells and other parameters of humoral immunity.	Nitrogen Dioxide	211-214	CD19 molecule	Homo sapiens	285-289
9322519-9	1997	Treatment with the selective iNOS inhibitor, aminoguanidine, inhibited iNOS enzymatic activity and overproduction of NO2-/NO3-.	Nitrogen Dioxide	117-121	nitric oxide synthase 2	Rattus norvegicus	29-33
9435578-9	1997	Rats were exposed to 18 parts/ million NO2 for 12 h; control rats received filtered air for 12 h. In NO2-exposed rats, the total amount of rTI40 in bronchoalveolar fluid was elevated 2-fold compared with control values (P < 0.001); protein concentration was 8.5-fold of control values (P < 0.001).	Nitrogen Dioxide	39-42	podoplanin	Rattus norvegicus	139-144
9435578-9	1997	Rats were exposed to 18 parts/ million NO2 for 12 h; control rats received filtered air for 12 h. In NO2-exposed rats, the total amount of rTI40 in bronchoalveolar fluid was elevated 2-fold compared with control values (P < 0.001); protein concentration was 8.5-fold of control values (P < 0.001).	Nitrogen Dioxide	101-104	podoplanin	Rattus norvegicus	139-144
9437521-4	1997	Here we report that in the presence of nitrite ions (NO2-), MXH2 undergoes oxidation by the mammalian enzyme lactoperoxidase (LPO) and hydrogen peroxide and that the process proceeds at a rate that is proportional to NO2- concentration.	Nitrogen Dioxide	53-56	lactoperoxidase	Homo sapiens	109-124
9437521-4	1997	Here we report that in the presence of nitrite ions (NO2-), MXH2 undergoes oxidation by the mammalian enzyme lactoperoxidase (LPO) and hydrogen peroxide and that the process proceeds at a rate that is proportional to NO2- concentration.	Nitrogen Dioxide	53-56	lactoperoxidase	Homo sapiens	126-129
9371773-7	1997	Proportional inhibition of iNOS activity as measured by decreased NO products in the medium (NO2- and NO3-) resulted from selenite addition to cell suspensions.	Nitrogen Dioxide	93-96	nitric oxide synthase 2	Homo sapiens	27-31
10100492-6	1998	Inhibition of nitric oxide synthesis with L-NAME during activation with IFN-gamma + LPS reduced NO2- production to the same extent in both cell lines; however, cellular accumulation of nitrotyrosine was reduced by only 25% in the transfectant (P = 0.21) and 49% in the parent cell line (P = 0.007), suggesting that intracellular nitrite increased nitrotyrosine accumulation through a pathway not requiring NO synthesis, i.e., myeloperoxidase system.	Nitrogen Dioxide	96-99	interferon gamma	Mus musculus	72-81
9407050-4	1997	Myeloperoxidase (MPO) also catalyzed nitration and chlorination of fluorescein and the fluorescein-conjugated particles in cell-free solutions; the relative nitration yields increased with increasing [NO2-]/[Cl-] ratios.	Nitrogen Dioxide	201-205	myeloperoxidase	Homo sapiens	0-15
9407050-4	1997	Myeloperoxidase (MPO) also catalyzed nitration and chlorination of fluorescein and the fluorescein-conjugated particles in cell-free solutions; the relative nitration yields increased with increasing [NO2-]/[Cl-] ratios.	Nitrogen Dioxide	201-205	myeloperoxidase	Homo sapiens	17-20
9407050-7	1997	These data indicate that intraphagosomal aromatic nitration in neutrophils is negligible, although extracellular nitration of phenolic compounds by secreted MPO could occur at physiological concentration levels of NO2-.	Nitrogen Dioxide	214-217	myeloperoxidase	Homo sapiens	157-160
9412571-4	1997	BAL NO2- was assayed using a modified Griess reaction after reduction of NO3- to NO2-.	Nitrogen Dioxide	4-7	NBL1, DAN family BMP antagonist	Homo sapiens	73-76
9437521-7	1997	We propose that oxidation of MXH2 is mediated by an LPO/ H2O2 metabolite of NO2-, most likely the .NO2 radical.	Nitrogen Dioxide	76-79	lactoperoxidase	Homo sapiens	52-55
9279218-5	1997	In BW, exposure to NO2 induced a 1.5-fold increase in interleukin-8 (IL-8) (p < 0.05) at 1.5 h and a 2.5-fold increase in neutrophils (p < 0.01) at 6 h. In BAL fluid (BALF), small increases were observed in CD45RO+ lymphocytes, B-cells, and natural killer (NK) cells only.	Nitrogen Dioxide	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
9363475-8	1997	In contrast, NO2 caused a concentration-dependent inhibition of the secretion of all cytokines except IL-1 beta from smoker"s cells.	Nitrogen Dioxide	13-16	interleukin 1 beta	Homo sapiens	102-111
9363475-12	1997	Nitrogen dioxide also failed to elevate the levels of the mRNAs in non-smoker"s cells but, again, tended to diminish the levels, particularly of IL-1 beta mRNA.	Nitrogen Dioxide	0-16	interleukin 1 beta	Homo sapiens	145-154
9279218-5	1997	In BW, exposure to NO2 induced a 1.5-fold increase in interleukin-8 (IL-8) (p < 0.05) at 1.5 h and a 2.5-fold increase in neutrophils (p < 0.01) at 6 h. In BAL fluid (BALF), small increases were observed in CD45RO+ lymphocytes, B-cells, and natural killer (NK) cells only.	Nitrogen Dioxide	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
9236211-14	1997	Accumulation of intracellular NO3-, measured by the Greiss method after reduction to NO2-, indicated that the anion is translocated into the cells along with the movement of acid equivalents.	Nitrogen Dioxide	85-88	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
9192827-7	1997	Experiments designed to investigate the role of tumor necrosis factor alpha (TNF-alpha) in NO2- production by Bryo- and IFN-gamma-activated macrophages revealed that ANA-1 macrophages expressed low levels of TNF-alpha mRNA constitutively that were not augmented in the presence of IFN-gamma.	Nitrogen Dioxide	91-94	tumor necrosis factor	Mus musculus	48-75
9437769-3	1997	Albumin, reduced glutathione (GSH), cysteine and N-acetylcysteine, but not other amino acids lowered the amount of NO2- as detected by Griess" method no matter whether sodium nitrite or 3-morpholinosydnonimine (SIN-1) were used as a source of NO2-.	Nitrogen Dioxide	115-118	MAPK associated protein 1	Homo sapiens	211-216
9186487-10	1997	Of considerable importance was the fact that NO participates in activation of the neutrophil collagenase through its conversion to NO2 or ONOO- in human neutrophils.	Nitrogen Dioxide	131-134	matrix metallopeptidase 8	Homo sapiens	82-104
12223780-0	1997	In Vivo and in Vitro Studies of Glucose-6-Phosphate Dehydrogenase from Barley Root Plastids in Relation to Reductant Supply for NO2- Assimilation.	Nitrogen Dioxide	128-131	g6pdh	Hordeum vulgare	32-65
12223780-4	1997	In vitro, a ratio of 1.5 inactivated barley root plastid G6PDH by approximately 50%, suggesting that G6PDH could remain active during NO2- assimilation even at the high NADPH/NADP ratios that would favor a reduction of ferredoxin, the electron donor of NO2- reductase.	Nitrogen Dioxide	134-137	g6pdh	Hordeum vulgare	101-106
12223780-4	1997	In vitro, a ratio of 1.5 inactivated barley root plastid G6PDH by approximately 50%, suggesting that G6PDH could remain active during NO2- assimilation even at the high NADPH/NADP ratios that would favor a reduction of ferredoxin, the electron donor of NO2- reductase.	Nitrogen Dioxide	253-256	g6pdh	Hordeum vulgare	101-106
9192827-7	1997	Experiments designed to investigate the role of tumor necrosis factor alpha (TNF-alpha) in NO2- production by Bryo- and IFN-gamma-activated macrophages revealed that ANA-1 macrophages expressed low levels of TNF-alpha mRNA constitutively that were not augmented in the presence of IFN-gamma.	Nitrogen Dioxide	91-94	tumor necrosis factor	Mus musculus	77-86
9192827-7	1997	Experiments designed to investigate the role of tumor necrosis factor alpha (TNF-alpha) in NO2- production by Bryo- and IFN-gamma-activated macrophages revealed that ANA-1 macrophages expressed low levels of TNF-alpha mRNA constitutively that were not augmented in the presence of IFN-gamma.	Nitrogen Dioxide	91-94	interferon gamma	Mus musculus	120-129
9192827-10	1997	Neutralizing concentrations of anti-TNF-alpha antibody suppressed the Bryo plus IFN-gamma-induced NO2- production approximately by 50%, suggesting that NO2- produced by Bryo plus IFN-gamma-treated ANA-1 macrophages may involve both TNF-alpha-dependent and TNF-alpha-independent mechanisms.	Nitrogen Dioxide	98-101	tumor necrosis factor	Mus musculus	36-45
9192827-10	1997	Neutralizing concentrations of anti-TNF-alpha antibody suppressed the Bryo plus IFN-gamma-induced NO2- production approximately by 50%, suggesting that NO2- produced by Bryo plus IFN-gamma-treated ANA-1 macrophages may involve both TNF-alpha-dependent and TNF-alpha-independent mechanisms.	Nitrogen Dioxide	98-101	interferon gamma	Mus musculus	80-89
9192827-10	1997	Neutralizing concentrations of anti-TNF-alpha antibody suppressed the Bryo plus IFN-gamma-induced NO2- production approximately by 50%, suggesting that NO2- produced by Bryo plus IFN-gamma-treated ANA-1 macrophages may involve both TNF-alpha-dependent and TNF-alpha-independent mechanisms.	Nitrogen Dioxide	152-155	tumor necrosis factor	Mus musculus	36-45
9192827-10	1997	Neutralizing concentrations of anti-TNF-alpha antibody suppressed the Bryo plus IFN-gamma-induced NO2- production approximately by 50%, suggesting that NO2- produced by Bryo plus IFN-gamma-treated ANA-1 macrophages may involve both TNF-alpha-dependent and TNF-alpha-independent mechanisms.	Nitrogen Dioxide	152-155	interferon gamma	Mus musculus	80-89
9192827-10	1997	Neutralizing concentrations of anti-TNF-alpha antibody suppressed the Bryo plus IFN-gamma-induced NO2- production approximately by 50%, suggesting that NO2- produced by Bryo plus IFN-gamma-treated ANA-1 macrophages may involve both TNF-alpha-dependent and TNF-alpha-independent mechanisms.	Nitrogen Dioxide	152-155	interferon gamma	Mus musculus	179-188
9192827-10	1997	Neutralizing concentrations of anti-TNF-alpha antibody suppressed the Bryo plus IFN-gamma-induced NO2- production approximately by 50%, suggesting that NO2- produced by Bryo plus IFN-gamma-treated ANA-1 macrophages may involve both TNF-alpha-dependent and TNF-alpha-independent mechanisms.	Nitrogen Dioxide	152-155	tumor necrosis factor	Mus musculus	232-241
9192827-10	1997	Neutralizing concentrations of anti-TNF-alpha antibody suppressed the Bryo plus IFN-gamma-induced NO2- production approximately by 50%, suggesting that NO2- produced by Bryo plus IFN-gamma-treated ANA-1 macrophages may involve both TNF-alpha-dependent and TNF-alpha-independent mechanisms.	Nitrogen Dioxide	152-155	tumor necrosis factor	Mus musculus	232-241
9192827-11	1997	Overall, these findings provide the first evidence that Bryo and IFN-gamma can synergize for the induction of NO2- production as well as iNOS gene expression and show the involvement of posttranscriptional mechanisms in the induction of iNOS mRNA.	Nitrogen Dioxide	110-113	interferon gamma	Mus musculus	65-74
9109844-4	1997	Bolus intravenous injection of insulin (0.1 IU/kg body weight) caused a significant increase in urinary excretion of NO2-/NO3- together with a significant decrease in blood pressure, whereas saline infusion alone had no effect on these parameters.	Nitrogen Dioxide	117-122	insulin	Homo sapiens	31-38
9174292-5	1997	The resultant iNOS expression was measured by using Northern blot analysis and cell supernatant nitrite concentrations (in aqueous media, NO is oxidized primarily to nitrite, NO2-) by chemiluminescence.	Nitrogen Dioxide	175-178	nitric oxide synthase 2, inducible	Mus musculus	14-18
9168790-7	1997	Acetylcholine, norepinephrine, angiotensin II, and bradykinin caused greater increases in NO2- production in coronary microvessels from exercise-trained dogs compared with those from normal dogs.	Nitrogen Dioxide	90-93	kininogen 1	Canis lupus familiaris	51-61
9182711-1	1997	The first quantitative characterization of the interaction of NO2(-) with the Cu-containing dissimilatory nitrite reductase (NiR) of Alcaligenes xylosoxidans using steady-state kinetics, equilibrium gel filtration and EPR spectroscopy is described.	Nitrogen Dioxide	62-65	nitrite reductase large subunit	Achromobacter xylosoxidans	106-123
9182711-1	1997	The first quantitative characterization of the interaction of NO2(-) with the Cu-containing dissimilatory nitrite reductase (NiR) of Alcaligenes xylosoxidans using steady-state kinetics, equilibrium gel filtration and EPR spectroscopy is described.	Nitrogen Dioxide	62-65	nitrite reductase large subunit	Achromobacter xylosoxidans	125-128
9182711-4	1997	Equilibrium gel filtration showed that binding of NO2(-) to the oxidized NiR was also pH-dependent.	Nitrogen Dioxide	50-53	nitrite reductase large subunit	Achromobacter xylosoxidans	73-76
9182711-7	1997	4.1 NO2(-) ions bound per trimeric NiR molecule.	Nitrogen Dioxide	4-7	nitrite reductase large subunit	Achromobacter xylosoxidans	35-38
9182711-9	1997	When corrected for this binding, a value of 3 NO2(-) ions bound per trimer of NiR, equivalent to the type-2 Cu content.	Nitrogen Dioxide	46-49	nitrite reductase large subunit	Achromobacter xylosoxidans	78-81
9176264-4	1997	PAEM were incubated with TNF-alpha (100 U/ml) for 4 h. Incubation of PAEM with TNF-alpha resulted in increases in 1) the .NO oxidation product nitrite (NO2-), 2) nitrotyrosine immunofluorescence, 3) the oxidation of p42 (tentatively identified as actin), and 4) permeability to Evans blue dye-albumin.	Nitrogen Dioxide	152-155	tumor necrosis factor	Homo sapiens	25-34
9176264-4	1997	PAEM were incubated with TNF-alpha (100 U/ml) for 4 h. Incubation of PAEM with TNF-alpha resulted in increases in 1) the .NO oxidation product nitrite (NO2-), 2) nitrotyrosine immunofluorescence, 3) the oxidation of p42 (tentatively identified as actin), and 4) permeability to Evans blue dye-albumin.	Nitrogen Dioxide	152-155	tumor necrosis factor	Homo sapiens	79-88
9176264-5	1997	The .NO synthase inhibitor aminoguanidine (100 microM) prevented the TNF-alpha-induced increase in NO2-, nitrotyrosine immunofluorescence, oxidized p42, and permeability.	Nitrogen Dioxide	99-102	tumor necrosis factor	Homo sapiens	69-78
9065416-5	1997	Phenolic nitration by MPO-catalyzed NO2- oxidation is only partially inhibited by chloride (Cl-), the presumed major physiological substrate for MPO.	Nitrogen Dioxide	36-39	myeloperoxidase	Homo sapiens	22-25
9701056-5	1997	To measure the stable end product NO3- by the Griess reaction or the DAN method, this anion must be reduced to NO2-.	Nitrogen Dioxide	111-114	NBL1, DAN family BMP antagonist	Homo sapiens	34-37
9701056-6	1997	We compared the capacity of bacterial nitrate reductase with the reducing metal cadmium to convert NO3- to NO2-.	Nitrogen Dioxide	107-110	NBL1, DAN family BMP antagonist	Homo sapiens	99-102
9701056-8	1997	We found that there was a high correlation (r2 = 0.998) in total NO2- concentrations in the study samples using both methods for reducing NO3- to NO2-.	Nitrogen Dioxide	65-68	NBL1, DAN family BMP antagonist	Homo sapiens	138-141
9701056-8	1997	We found that there was a high correlation (r2 = 0.998) in total NO2- concentrations in the study samples using both methods for reducing NO3- to NO2-.	Nitrogen Dioxide	146-149	NBL1, DAN family BMP antagonist	Homo sapiens	138-141
9065416-5	1997	Phenolic nitration by MPO-catalyzed NO2- oxidation is only partially inhibited by chloride (Cl-), the presumed major physiological substrate for MPO.	Nitrogen Dioxide	36-39	myeloperoxidase	Homo sapiens	145-148
9065416-6	1997	In fact, low concentrations of NO2- (2-10 microM) catalyze MPO-mediated oxidation of Cl-, indicated by increased chlorination of monochlorodimedon or 4-hydroxyphenylacetic acid, most likely via reduction of MPO compound II.	Nitrogen Dioxide	31-34	myeloperoxidase	Homo sapiens	59-62
9065416-6	1997	In fact, low concentrations of NO2- (2-10 microM) catalyze MPO-mediated oxidation of Cl-, indicated by increased chlorination of monochlorodimedon or 4-hydroxyphenylacetic acid, most likely via reduction of MPO compound II.	Nitrogen Dioxide	31-34	myeloperoxidase	Homo sapiens	207-210
9065416-8	1997	Collectively, our results suggest that NO2-, at physiological or pathological levels, is a substrate for the mammalian peroxidases MPO and lactoperoxidase and that formation of NO2.	Nitrogen Dioxide	39-42	myeloperoxidase	Homo sapiens	131-134
9065416-8	1997	Collectively, our results suggest that NO2-, at physiological or pathological levels, is a substrate for the mammalian peroxidases MPO and lactoperoxidase and that formation of NO2.	Nitrogen Dioxide	39-42	lactoperoxidase	Homo sapiens	139-154
9134219-9	1997	The effect of staurosporine on both basal and IL-1 beta-stimulated NO2- production was concentration-dependent with an apparent maximum at 3 nM.	Nitrogen Dioxide	67-70	interleukin 1 beta	Rattus norvegicus	46-55
9144455-0	1997	Nitrogen dioxide exposure activates gamma-glutamyl transferase gene expression in rat lung.	Nitrogen Dioxide	0-16	gamma-glutamyltransferase 1	Rattus norvegicus	36-62
9144455-2	1997	Since GGT is a key enzyme in glutathione metabolism and we have previously characterized GGT expression in distal lung epithelium and in lung surfactant, we examined the NO2 exposed lung for induction of gamma-glutamyl transferase (GGT) mRNA, protein, and enzyme activity.	Nitrogen Dioxide	170-173	gamma-glutamyltransferase 1	Rattus norvegicus	204-230
9144455-3	1997	We found that the GGT gene product is induced in lung by NO2.	Nitrogen Dioxide	57-60	gamma-glutamyltransferase 1	Rattus norvegicus	18-21
9144455-9	1997	Our studies show that NO2 induces GGT mRNA expression, including GGT mRNA1, in lung and GGT protein and enzyme activity in lung and lung lavage in response to the oxidative stress of NO2 inhalation.	Nitrogen Dioxide	22-25	gamma-glutamyltransferase 1	Rattus norvegicus	34-37
9144455-9	1997	Our studies show that NO2 induces GGT mRNA expression, including GGT mRNA1, in lung and GGT protein and enzyme activity in lung and lung lavage in response to the oxidative stress of NO2 inhalation.	Nitrogen Dioxide	22-25	gamma-glutamyltransferase 1	Rattus norvegicus	65-68
9144455-9	1997	Our studies show that NO2 induces GGT mRNA expression, including GGT mRNA1, in lung and GGT protein and enzyme activity in lung and lung lavage in response to the oxidative stress of NO2 inhalation.	Nitrogen Dioxide	22-25	gamma-glutamyltransferase 1	Rattus norvegicus	65-68
9144455-9	1997	Our studies show that NO2 induces GGT mRNA expression, including GGT mRNA1, in lung and GGT protein and enzyme activity in lung and lung lavage in response to the oxidative stress of NO2 inhalation.	Nitrogen Dioxide	183-186	gamma-glutamyltransferase 1	Rattus norvegicus	34-37
9144455-9	1997	Our studies show that NO2 induces GGT mRNA expression, including GGT mRNA1, in lung and GGT protein and enzyme activity in lung and lung lavage in response to the oxidative stress of NO2 inhalation.	Nitrogen Dioxide	183-186	gamma-glutamyltransferase 1	Rattus norvegicus	65-68
9144455-9	1997	Our studies show that NO2 induces GGT mRNA expression, including GGT mRNA1, in lung and GGT protein and enzyme activity in lung and lung lavage in response to the oxidative stress of NO2 inhalation.	Nitrogen Dioxide	183-186	gamma-glutamyltransferase 1	Rattus norvegicus	65-68
9048779-4	1997	2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazolin-1-oxyl 3-oxide (PTIO), which is able to scavenge NO radicals and generate nitrogen dioxide radicals (.NO2), potentiated the inhibition of this enzyme activity induced by all NO donors (except SIN-1).	Nitrogen Dioxide	152-155	MAPK associated protein 1	Homo sapiens	242-247
8977400-1	1997	In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium.	Nitrogen Dioxide	265-268	interleukin 1 beta	Homo sapiens	29-47
10325618-5	1997	As a natural antioxidant, tea contains several antioxidants, such as ascorbic acid and catechins, which removed NO2- from tap water effectively.	Nitrogen Dioxide	112-115	SEC14 like lipid binding 2	Homo sapiens	122-125
9208057-6	1997	Air pollutants, such as ozone and nitrogen dioxide (NO2), have been shown to stimulate the production of granulocyte-macrophage colony stimulating factor, which may play a vital role in airway hyperreactivity and asthma.	Nitrogen Dioxide	34-50	colony stimulating factor 2	Homo sapiens	105-153
9208057-6	1997	Air pollutants, such as ozone and nitrogen dioxide (NO2), have been shown to stimulate the production of granulocyte-macrophage colony stimulating factor, which may play a vital role in airway hyperreactivity and asthma.	Nitrogen Dioxide	52-55	colony stimulating factor 2	Homo sapiens	105-153
9013592-7	1997	Determination of NO2- and NO3- in solutions of decomposed peroxynitrite showed that the relative amount of NO2- increased with increasing pH, with NO2- accounting for about 30% of decomposition products at pH 7.5 and NO3- being the sole metabolite at pH 3.0.	Nitrogen Dioxide	107-110	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
9013592-7	1997	Determination of NO2- and NO3- in solutions of decomposed peroxynitrite showed that the relative amount of NO2- increased with increasing pH, with NO2- accounting for about 30% of decomposition products at pH 7.5 and NO3- being the sole metabolite at pH 3.0.	Nitrogen Dioxide	107-110	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
9013592-9	1997	The two reactions yielding NO2- and NO3- showed distinct temperature dependences from which a difference in Eact of 26.2 +/- 0.9 kJ mol-1 was calculated.	Nitrogen Dioxide	27-30	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
10072993-2	1997	The results showed that the concentration of NO2-/NO3- and the levels of TNF-alpha and IL-8 in CSF of the two kinds of meningitis were higher than those of normal CSF, and the concentration of NO2-/NO3- correlated positively to the content of TNF-alpha.	Nitrogen Dioxide	193-196	tumor necrosis factor	Homo sapiens	243-252
8977400-1	1997	In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium.	Nitrogen Dioxide	265-268	interleukin 1 beta	Homo sapiens	49-58
8977400-3	1997	The effect of IL-1 beta on citrulline biosynthesis and NO2- accumulation was abrogated by the NOS inhibitor NG-methyl-L-arginine or the IL-1-receptor antagonist protein.	Nitrogen Dioxide	55-58	interleukin 1 beta	Homo sapiens	14-23
8977400-4	1997	In contrast bacterial endotoxin (lipopolysaccharide), interferon-gamma, or tumor necrosis factor-alpha, which are well known inducers of inducible NOS (iNOS) in a variety of immunocompetent and nonimmunocompetent cell types, failed to increase [3H]citrulline formation or NO2- accumulation in untreated or FSH-stimulated cells.	Nitrogen Dioxide	272-275	interferon gamma	Homo sapiens	54-102
8977400-4	1997	In contrast bacterial endotoxin (lipopolysaccharide), interferon-gamma, or tumor necrosis factor-alpha, which are well known inducers of inducible NOS (iNOS) in a variety of immunocompetent and nonimmunocompetent cell types, failed to increase [3H]citrulline formation or NO2- accumulation in untreated or FSH-stimulated cells.	Nitrogen Dioxide	272-275	nitric oxide synthase 2	Homo sapiens	137-150
8977400-4	1997	In contrast bacterial endotoxin (lipopolysaccharide), interferon-gamma, or tumor necrosis factor-alpha, which are well known inducers of inducible NOS (iNOS) in a variety of immunocompetent and nonimmunocompetent cell types, failed to increase [3H]citrulline formation or NO2- accumulation in untreated or FSH-stimulated cells.	Nitrogen Dioxide	272-275	nitric oxide synthase 2	Homo sapiens	152-156
9812557-5	1997	The concentration of NO2-/NO3- had a positive correlation with that of endotoxin and TNF alpha (r = 0.481, P < 0.01; r = 0.351, P < 0.05).	Nitrogen Dioxide	21-24	tumor necrosis factor	Homo sapiens	71-94
9058189-2	1997	An about 5-6-fold higher amount of NO2-originating from the nitric oxide radical (.NO) was produced in the culture supernatant of macrophages treated with LPS + IFN-gamma than with LPS alone, depending on both the time of incubation and the dose of LPS.	Nitrogen Dioxide	35-38	interferon gamma	Mus musculus	161-170
9000533-5	1997	The inducible isoform of NOS (iNOS) appeared to be responsible for the elevated NO2-/NO3- response in C. parvum mice because iNOS transcripts were readily detected in their livers.	Nitrogen Dioxide	80-83	nitric oxide synthase 2, inducible	Mus musculus	30-34
8773588-6	1996	Macrophages from TGF-beta1+/+ mice appeared to produce NO in a manner inversely proportional to the serum content of NO2- and NO3- of the mice from which the cells were obtained; no such correlation existed in TGF-beta1+/- or TGF-beta1-/- mice.	Nitrogen Dioxide	117-120	transforming growth factor, beta 1	Mus musculus	17-26
8897830-3	1996	Removal of glucose from the media partially inhibited IL-1 beta-stimulated nitrite (NO2-) production [8.1 +/- 0.3 vs. 4.4 +/- 0.6 nmol.	Nitrogen Dioxide	84-87	interleukin 1 beta	Rattus norvegicus	54-63
8897830-5	1996	The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) completely inhibited IL-1 beta-stimulated NO2- production [0.7 +/- 0.5 nmol.	Nitrogen Dioxide	92-95	interleukin 1 beta	Rattus norvegicus	71-80
9275511-9	1996	High VE and high NO, NO2 values were greater with VIP BIRD ventilator than with Servo 900C ventilator.	Nitrogen Dioxide	21-24	vasoactive intestinal peptide	Homo sapiens	50-53
8897830-7	1996	The addition of the glycolytic end product, pyruvate, completely blocked the 2-DG inhibition of IL-1 beta-stimulated NO2- production [7.4 +/- 0.4 nmol.	Nitrogen Dioxide	117-120	interleukin 1 beta	Rattus norvegicus	96-105
8760140-2	1996	Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrogen Dioxide	262-265	interleukin 1 beta	Rattus norvegicus	66-84
8880896-6	1996	Reduced synthesis of NO2- was associated with reduced NOS-2 mRNA levels suggesting that the induction of NOS-2 was inhibited.	Nitrogen Dioxide	21-24	nitric oxide synthase 2	Rattus norvegicus	54-59
8880896-6	1996	Reduced synthesis of NO2- was associated with reduced NOS-2 mRNA levels suggesting that the induction of NOS-2 was inhibited.	Nitrogen Dioxide	21-24	nitric oxide synthase 2	Rattus norvegicus	105-110
9275434-4	1996	RESULTS: (1) The plasma concentration of NO2-/NO2- and cGMP in patients with PIH decreased significantly when compared with that of healthy pregnant women (P < 0.01).	Nitrogen Dioxide	41-44	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	77-80
9275434-4	1996	RESULTS: (1) The plasma concentration of NO2-/NO2- and cGMP in patients with PIH decreased significantly when compared with that of healthy pregnant women (P < 0.01).	Nitrogen Dioxide	46-49	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	77-80
9275434-6	1996	(3) There was a negative correlation between the plasma NO2-/NO3- level and systolic blood pressure in PIH (P < 0.01).	Nitrogen Dioxide	56-59	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	103-106
9275434-7	1996	(4) A positive correlation was seen between plasma NO2-/NO3- levels and cGMP levels in PIH patients (P < 0.01).	Nitrogen Dioxide	51-54	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	87-90
8760140-4	1996	Stimulation with IL-1 beta and TNF-alpha plus H2O2 or IL-1 beta and LPS plus H2O2 increased the synthesis of NO2- and NO3- by 3.8- and 3.5-fold, respectively.	Nitrogen Dioxide	109-112	interleukin 1 beta	Rattus norvegicus	17-26
8760140-2	1996	Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrogen Dioxide	262-265	tumor necrosis factor	Rattus norvegicus	98-125
8760140-4	1996	Stimulation with IL-1 beta and TNF-alpha plus H2O2 or IL-1 beta and LPS plus H2O2 increased the synthesis of NO2- and NO3- by 3.8- and 3.5-fold, respectively.	Nitrogen Dioxide	109-112	tumor necrosis factor	Rattus norvegicus	31-40
8760140-4	1996	Stimulation with IL-1 beta and TNF-alpha plus H2O2 or IL-1 beta and LPS plus H2O2 increased the synthesis of NO2- and NO3- by 3.8- and 3.5-fold, respectively.	Nitrogen Dioxide	109-112	interleukin 1 beta	Rattus norvegicus	54-63
8760140-2	1996	Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrogen Dioxide	262-265	interferon gamma	Rattus norvegicus	139-155
8760143-0	1996	In vivo exposure to NO2 reduces TNF and IL-6 production by endotoxin-stimulated alveolar macrophages.	Nitrogen Dioxide	20-23	tumor necrosis factor-like	Rattus norvegicus	32-35
8760140-2	1996	Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrogen Dioxide	262-265	interferon gamma	Rattus norvegicus	157-166
8760143-0	1996	In vivo exposure to NO2 reduces TNF and IL-6 production by endotoxin-stimulated alveolar macrophages.	Nitrogen Dioxide	20-23	interleukin 6	Rattus norvegicus	40-44
8813644-2	1996	NO synthase activity (NO2- accumulation) and 130 kDa protein of inducible NO synthase were induced 24 h after treatment with interferon-gamma or lipopolysaccharide in both glial cells and RAW264.7 macrophages.	Nitrogen Dioxide	22-25	interferon gamma	Rattus norvegicus	125-141
8760143-3	1996	TNF and IL-6 production was significantly decreased (four-to sixfold) in the cell lysate of alveolar macrophages isolated from rats exposed to NO2.	Nitrogen Dioxide	143-146	tumor necrosis factor-like	Rattus norvegicus	0-3
8760143-3	1996	TNF and IL-6 production was significantly decreased (four-to sixfold) in the cell lysate of alveolar macrophages isolated from rats exposed to NO2.	Nitrogen Dioxide	143-146	interleukin 6	Rattus norvegicus	8-12
8760143-7	1996	We can conclude that rats exposed to NO2 produce less TNF and IL-6 and that this might be related to increased PGE2 production and increased expression of TNF-R1.	Nitrogen Dioxide	37-40	tumor necrosis factor-like	Rattus norvegicus	54-57
8760143-7	1996	We can conclude that rats exposed to NO2 produce less TNF and IL-6 and that this might be related to increased PGE2 production and increased expression of TNF-R1.	Nitrogen Dioxide	37-40	interleukin 6	Rattus norvegicus	62-66
8760143-7	1996	We can conclude that rats exposed to NO2 produce less TNF and IL-6 and that this might be related to increased PGE2 production and increased expression of TNF-R1.	Nitrogen Dioxide	37-40	TNF receptor superfamily member 1A	Rattus norvegicus	155-161
8766815-1	1996	The present study examines whether nitrogen dioxide (NO2)-induced activation of protein kinase C (PKC) is associated with increased expression of specific PKC isoforms and/or with enhanced generation of phosphatidylcholine(PC)-derived diacylglycerol (DAG) in pulmonary artery endothelial cells (PAEC).	Nitrogen Dioxide	35-51	protein kinase C alpha	Homo sapiens	98-101
8766815-1	1996	The present study examines whether nitrogen dioxide (NO2)-induced activation of protein kinase C (PKC) is associated with increased expression of specific PKC isoforms and/or with enhanced generation of phosphatidylcholine(PC)-derived diacylglycerol (DAG) in pulmonary artery endothelial cells (PAEC).	Nitrogen Dioxide	35-51	protein kinase C alpha	Homo sapiens	155-158
8766815-1	1996	The present study examines whether nitrogen dioxide (NO2)-induced activation of protein kinase C (PKC) is associated with increased expression of specific PKC isoforms and/or with enhanced generation of phosphatidylcholine(PC)-derived diacylglycerol (DAG) in pulmonary artery endothelial cells (PAEC).	Nitrogen Dioxide	53-56	protein kinase C alpha	Homo sapiens	98-101
8766815-1	1996	The present study examines whether nitrogen dioxide (NO2)-induced activation of protein kinase C (PKC) is associated with increased expression of specific PKC isoforms and/or with enhanced generation of phosphatidylcholine(PC)-derived diacylglycerol (DAG) in pulmonary artery endothelial cells (PAEC).	Nitrogen Dioxide	53-56	protein kinase C alpha	Homo sapiens	155-158
8766815-2	1996	Western blot analysis revealed that exposure to 5 ppm NO2 resulted in increased expression of PKC alpha and epsilon isoforms in both cytosol and membrane fractions in a time-dependent fashion compared with controls.	Nitrogen Dioxide	54-57	protein kinase C alpha	Homo sapiens	94-103
8766815-8	1996	These results show for the first time that exposure of PAEC to NO2 results in elevated expression of specific PKC isoforms and in enhanced generation of cellular DAG, and the latter appears to arise largely from the hydrolysis of plasma membrane PC.	Nitrogen Dioxide	63-66	protein kinase C alpha	Homo sapiens	110-113
8835635-1	1996	To clarify the hypothesis that organic nitrates are converted to nitric oxide (NO) via nitrite ion (NO2-) by glutathione S-transferase, the metabolic conversion of four nitrates was examined in pig coronary arteries and compared with that in rat liver.	Nitrogen Dioxide	100-103	microsomal glutathione S-transferase 1	Sus scrofa	109-134
8726938-9	1996	We found an increased expression of Mac-1 on granulocytes 30 min after NO2 exposure when compared to pre-exposure values.	Nitrogen Dioxide	71-74	integrin subunit alpha M	Homo sapiens	36-41
8648601-13	1996	ADA catalyzes the hydrolysis of the 6-substituents at rates which vary from slightly slower (NO2, 1.7x) to much slower (NHEt, 5000x) than F-ddA.	Nitrogen Dioxide	93-96	adenosine deaminase	Homo sapiens	0-3
8617930-7	1996	LPS and IFN-gamma synergized to increase NO2- production from IRF-2-/- M phi to approximately 50% of IRF-2+/- and C57BL/6 levels.	Nitrogen Dioxide	41-44	interferon gamma	Mus musculus	8-17
8617930-7	1996	LPS and IFN-gamma synergized to increase NO2- production from IRF-2-/- M phi to approximately 50% of IRF-2+/- and C57BL/6 levels.	Nitrogen Dioxide	41-44	interferon regulatory factor 2	Mus musculus	62-67
8617930-7	1996	LPS and IFN-gamma synergized to increase NO2- production from IRF-2-/- M phi to approximately 50% of IRF-2+/- and C57BL/6 levels.	Nitrogen Dioxide	41-44	interferon regulatory factor 2	Mus musculus	101-106
8617930-9	1996	IRF-1-/- M phi produced barely detectable NO2- and low, but detectable, inducible NO.	Nitrogen Dioxide	42-45	interferon regulatory factor 1	Mus musculus	0-5
8735839-2	1996	The rate constants, K/Ki, for the inactivation of tissue-type plasminogen activator enzyme (t-PA) are 470-750 M-1 S-1 with PMN, 4-CH3-PMN, and 4-CH3O-PMN in pH 7.8, 0.05 M Tris buffer at 7.0 +/- 0.5 degrees C, but t-PA cannot be inhibited with the 4-Cl and NO2 derivatives due to rapid competing hydrolysis.	Nitrogen Dioxide	257-260	plasminogen activator, tissue type	Homo sapiens	50-90
8735839-2	1996	The rate constants, K/Ki, for the inactivation of tissue-type plasminogen activator enzyme (t-PA) are 470-750 M-1 S-1 with PMN, 4-CH3-PMN, and 4-CH3O-PMN in pH 7.8, 0.05 M Tris buffer at 7.0 +/- 0.5 degrees C, but t-PA cannot be inhibited with the 4-Cl and NO2 derivatives due to rapid competing hydrolysis.	Nitrogen Dioxide	257-260	plasminogen activator, tissue type	Homo sapiens	92-96
8762862-4	1996	Pretreatment of CF2 with anti-CF2-antisera (CF2-As) inhibited the production of NO2-.	Nitrogen Dioxide	80-84	coagulation factor II	Mus musculus	30-33
8762862-7	1996	The findings of the present study thus demonstrate that CF2 induces production of NO2- in the spleen cells in a CA(2+)-dependent manner which may be a mechanism of target cell killing.	Nitrogen Dioxide	82-85	coagulation factor II	Mus musculus	56-59
8762862-2	1996	The present study was undertaken to investigate the production of nitrite (NO2-) by the spleen cells of mice in vitro and in vivo following inoculation of CF2.	Nitrogen Dioxide	75-78	coagulation factor II	Mus musculus	155-158
8534489-0	1996	Nitrogen dioxide exposure increases airway contractile response to histamine by decreasing histamine N-methyltransferase activity in guinea pigs.	Nitrogen Dioxide	0-16	histamine N-methyltransferase	Cavia porcellus	91-120
8762862-3	1996	Maximum NO2- production occurred at 1 hour after inoculation of 100 micrograms CF2.	Nitrogen Dioxide	8-11	coagulation factor II	Mus musculus	79-82
8762862-4	1996	Pretreatment of CF2 with anti-CF2-antisera (CF2-As) inhibited the production of NO2-.	Nitrogen Dioxide	80-84	coagulation factor II	Mus musculus	16-19
8762862-4	1996	Pretreatment of CF2 with anti-CF2-antisera (CF2-As) inhibited the production of NO2-.	Nitrogen Dioxide	80-84	coagulation factor II	Mus musculus	30-33
8838085-12	1996	Viral infection, NO2 inhalation and allergen challenge modulate HMT activity in airway, which is important in the pathogenesis of asthma.	Nitrogen Dioxide	17-20	histamine N-methyltransferase	Homo sapiens	64-67
8534489-4	1996	HMT activity in trachea was decreased from the control value of 70.3 +/- 7.7 pmol/min/mg protein to 34.6 +/- 6.7 pmol/min/mg protein by 12 h exposures of NO2.	Nitrogen Dioxide	154-157	histamine N-methyltransferase	Cavia porcellus	0-3
8534489-6	1996	In contrast, HMT activity exceeded the control value by 96 h exposures of NO2 (85.5 +/- 5.1 pmol/min/mg protein).	Nitrogen Dioxide	74-77	histamine N-methyltransferase	Cavia porcellus	13-16
8534489-11	1996	In situ hybridization for HMT mRNA demonstrated that the level of HMT mRNA increased dominantly in tracheal epithelial cells after 96 h exposures of NO2.	Nitrogen Dioxide	149-152	histamine N-methyltransferase	Cavia porcellus	26-29
8534489-11	1996	In situ hybridization for HMT mRNA demonstrated that the level of HMT mRNA increased dominantly in tracheal epithelial cells after 96 h exposures of NO2.	Nitrogen Dioxide	149-152	histamine N-methyltransferase	Cavia porcellus	66-69
8534489-12	1996	The present results indicated that the decrease in the level of HMT activity in the trachea was closely associated with the increase in the airway contractile response to histamine, suggesting that NO2-induced transient airway hyperresponsiveness to histamine is due to the decreased capacity of histamine catabolism in airway.	Nitrogen Dioxide	198-201	histamine N-methyltransferase	Cavia porcellus	64-67
8560494-7	1995	We conclude that the IC-21 cell line may represent a suitable model for studying the role of stimulated cytokine gene expression in inflammation and that the early events in the pulmonary inflammatory response to the inhalation of NO2 do not involve stimulated release of TNF-alpha, IL-1 beta or MIP-1 alpha/MIP-1 beta from macrophages.	Nitrogen Dioxide	231-234	interleukin 1 beta	Mus musculus	283-292
8818631-6	1996	Induction of GRP-78 by NO2 exposure was regulated at the transcriptional level, and the induction required de novo protein synthesis.	Nitrogen Dioxide	23-26	heat shock protein family A (Hsp70) member 5	Homo sapiens	13-19
8818631-8	1996	Exposure of cell monolayers to tunicamycin, an inhibitor of protein glycosylation, mimicked the effect of NO2 exposure on expression of GRP-78.	Nitrogen Dioxide	106-109	heat shock protein family A (Hsp70) member 5	Homo sapiens	136-142
8818631-10	1996	These results demonstrate that exposure to NO2 increases expression of a number of proteins including GRP-78 in PAEC.	Nitrogen Dioxide	43-46	heat shock protein family A (Hsp70) member 5	Homo sapiens	102-108
8818631-11	1996	Increased expression of GRP-78 in NO2-exposed cells appears to be associated with inhibition of glycosylation or through coordinated alterations in metabolic events that lead to inhibition of protein glycosylation.	Nitrogen Dioxide	34-37	heat shock protein family A (Hsp70) member 5	Homo sapiens	24-30
24304013-3	1996	A marked increase in serum NO2 (-) + NO1 was observed at 19 hours after anti-CD3 (10 mu, IV) and additional IL-2 administrations (40 x 10(1) U, twice, If) induced a further increase.	Nitrogen Dioxide	27-30	CD3 antigen, epsilon polypeptide	Mus musculus	77-80
24304013-3	1996	A marked increase in serum NO2 (-) + NO1 was observed at 19 hours after anti-CD3 (10 mu, IV) and additional IL-2 administrations (40 x 10(1) U, twice, If) induced a further increase.	Nitrogen Dioxide	27-30	interleukin 2	Mus musculus	108-112
8747002-0	1996	Modulation of IL-1 beta, IL-6, IL-8, TNF-alpha, and TGF-beta secretions by alveolar macrophages under NO2 exposure.	Nitrogen Dioxide	102-105	interleukin 1 beta	Homo sapiens	14-23
8747002-0	1996	Modulation of IL-1 beta, IL-6, IL-8, TNF-alpha, and TGF-beta secretions by alveolar macrophages under NO2 exposure.	Nitrogen Dioxide	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
8747002-0	1996	Modulation of IL-1 beta, IL-6, IL-8, TNF-alpha, and TGF-beta secretions by alveolar macrophages under NO2 exposure.	Nitrogen Dioxide	102-105	tumor necrosis factor	Homo sapiens	37-46
8747002-0	1996	Modulation of IL-1 beta, IL-6, IL-8, TNF-alpha, and TGF-beta secretions by alveolar macrophages under NO2 exposure.	Nitrogen Dioxide	102-105	transforming growth factor beta 1	Homo sapiens	52-60
8747002-7	1996	Exposure for 30 min to NO2 induced a significant decrease of LPS-stimulated IL-1 Beta, IL-6, IL-8, and TNF-alpha (p < .05).	Nitrogen Dioxide	23-26	interleukin 1 beta	Homo sapiens	76-85
8747002-7	1996	Exposure for 30 min to NO2 induced a significant decrease of LPS-stimulated IL-1 Beta, IL-6, IL-8, and TNF-alpha (p < .05).	Nitrogen Dioxide	23-26	interleukin 6	Homo sapiens	87-91
8747002-7	1996	Exposure for 30 min to NO2 induced a significant decrease of LPS-stimulated IL-1 Beta, IL-6, IL-8, and TNF-alpha (p < .05).	Nitrogen Dioxide	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
8747002-7	1996	Exposure for 30 min to NO2 induced a significant decrease of LPS-stimulated IL-1 Beta, IL-6, IL-8, and TNF-alpha (p < .05).	Nitrogen Dioxide	23-26	tumor necrosis factor	Homo sapiens	103-112
8747002-10	1996	NO2 exposure of LPS-stimulated AM resulted in a functional impairment of AM after NO2 exposure regarding IL-1 beta, IL-6, IL-8, and TNF-alpha.	Nitrogen Dioxide	0-3	interleukin 1 beta	Homo sapiens	105-114
8747002-10	1996	NO2 exposure of LPS-stimulated AM resulted in a functional impairment of AM after NO2 exposure regarding IL-1 beta, IL-6, IL-8, and TNF-alpha.	Nitrogen Dioxide	0-3	interleukin 6	Homo sapiens	116-120
8747002-10	1996	NO2 exposure of LPS-stimulated AM resulted in a functional impairment of AM after NO2 exposure regarding IL-1 beta, IL-6, IL-8, and TNF-alpha.	Nitrogen Dioxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
8747002-10	1996	NO2 exposure of LPS-stimulated AM resulted in a functional impairment of AM after NO2 exposure regarding IL-1 beta, IL-6, IL-8, and TNF-alpha.	Nitrogen Dioxide	0-3	tumor necrosis factor	Homo sapiens	132-141
8747002-10	1996	NO2 exposure of LPS-stimulated AM resulted in a functional impairment of AM after NO2 exposure regarding IL-1 beta, IL-6, IL-8, and TNF-alpha.	Nitrogen Dioxide	82-85	interleukin 1 beta	Homo sapiens	105-114
8525517-5	1995	During episodes of acute GVHD, NO2-/NO3- concentrations showed a strong positive correlation with levels of plasma neopterin and sTNFrec 75, but were also significantly related to IL-10.	Nitrogen Dioxide	31-34	interleukin 10	Homo sapiens	180-185
8525517-6	1995	In non-GVHD patients, a negative correlation between IL-10 and NO2-/NO3- concentrations was evident.	Nitrogen Dioxide	63-66	interleukin 10	Homo sapiens	53-58
8560494-7	1995	We conclude that the IC-21 cell line may represent a suitable model for studying the role of stimulated cytokine gene expression in inflammation and that the early events in the pulmonary inflammatory response to the inhalation of NO2 do not involve stimulated release of TNF-alpha, IL-1 beta or MIP-1 alpha/MIP-1 beta from macrophages.	Nitrogen Dioxide	231-234	chemokine (C-C motif) ligand 3	Mus musculus	296-307
8560494-7	1995	We conclude that the IC-21 cell line may represent a suitable model for studying the role of stimulated cytokine gene expression in inflammation and that the early events in the pulmonary inflammatory response to the inhalation of NO2 do not involve stimulated release of TNF-alpha, IL-1 beta or MIP-1 alpha/MIP-1 beta from macrophages.	Nitrogen Dioxide	231-234	chemokine (C-C motif) ligand 4	Mus musculus	308-318
7499684-6	1995	Allergen challenge after exposure to both air and NO2 significantly (p < 0.05) increased levels of MCT, but not MPO and IL-8 in the nasal lavage fluid.	Nitrogen Dioxide	50-53	myeloperoxidase	Homo sapiens	115-118
7493969-6	1995	Adding superoxide dismutase to the medium markedly reduced the ratio of NO3- to NO2-, consistent with the hypothesis that NO3- in the medium results primarily from the extracellular reaction of NO with O2-..	Nitrogen Dioxide	80-83	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
8587249-4	1995	We found that ET-1 in MCs markedly reduced cytokine-induced NO production (measured as stable NO2-) and inhibited the expression of iNOS mRNA (Northern blot analysis) and of iNOS protein (Western blotting).	Nitrogen Dioxide	94-97	endothelin 1	Rattus norvegicus	14-18
8594915-2	1995	Maximal nitrite (NO2(-)) production by cultured neonatal rat cardiac myocytes was achieved with 500 U/ml interleukin-1 beta (IL-1 beta) for 48 h (4.6 +/- 0.3 nmol/1.25 x 10(5) cells; n = 12).	Nitrogen Dioxide	17-20	interleukin 1 beta	Rattus norvegicus	105-123
8594915-2	1995	Maximal nitrite (NO2(-)) production by cultured neonatal rat cardiac myocytes was achieved with 500 U/ml interleukin-1 beta (IL-1 beta) for 48 h (4.6 +/- 0.3 nmol/1.25 x 10(5) cells; n = 12).	Nitrogen Dioxide	17-20	interleukin 1 beta	Rattus norvegicus	125-134
8594915-5	1995	The addition of FSK or DBcAMP to IL-1 beta significantly increased NO2-) levels vs. IL-1 beta alone (9.7 +/- 0.6 and 10.9 +/- 0.8 vs. 4.6 +/- 0.3 nmol/1.25 x 10(5) cells per 48 h, respectively; P < 0.01; n = 12).	Nitrogen Dioxide	67-70	interleukin 1 beta	Rattus norvegicus	33-42
7499684-6	1995	Allergen challenge after exposure to both air and NO2 significantly (p < 0.05) increased levels of MCT, but not MPO and IL-8 in the nasal lavage fluid.	Nitrogen Dioxide	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
7499684-7	1995	In addition, allergen challenge after exposure to NO2 but not air, significantly increased levels of only ECP in nasal lavage fluid (p < 0.05).	Nitrogen Dioxide	50-53	ribonuclease A family member 3	Homo sapiens	106-109
7474002-4	1995	The ratio of NO2-:NO3- was significantly lower for burn patients versus controls in both plasma and urine (p < 0.01).	Nitrogen Dioxide	13-16	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
8680649-8	1995	NO2- + NO3- levels in the pleural effusion were directly related to IL-2 dose, and L-NAME treatment reduced both the NO production and severity of capillary leakage, excepting fluid retention in the kidney.	Nitrogen Dioxide	0-3	interleukin 2	Mus musculus	68-72
7536858-3	1995	LPS, tumor necrosis factor-alpha (TNF-alpha) and the combination of both were able to induce NO synthesis in a dose-dependent manner as measured with the determination of NO2- levels.	Nitrogen Dioxide	171-174	tumor necrosis factor	Rattus norvegicus	5-32
7501421-4	1995	Significantly higher levels of nitrite (NO2) were detected in supernatants from macrophage cultures treated with rIFN-gamma (10 u/ml or 100 u/ml) which induced microbistatic macrophage activity as well as from macrophage cultures treated with LPS + rIFN- when compared with levels of nitrite detected in supernatants of infected macrophages treated with medium only.	Nitrogen Dioxide	40-43	interferon gamma	Rattus norvegicus	113-123
7543422-4	1995	A murine macrophage-like cell line, J774.1, was activated with interferon-gamma (IFN-gamma) and bacterial lipopolysaccharide (LPS), which induced the production and secretion of NO2- into the culture supernatant.	Nitrogen Dioxide	178-182	interferon gamma	Mus musculus	63-79
7543422-4	1995	A murine macrophage-like cell line, J774.1, was activated with interferon-gamma (IFN-gamma) and bacterial lipopolysaccharide (LPS), which induced the production and secretion of NO2- into the culture supernatant.	Nitrogen Dioxide	178-182	interferon gamma	Mus musculus	81-90
7542281-4	1995	The time course of the induction of inducible nitric oxide synthase (iNOS) protein in the pouch tissue was found to coincide with the production of NO2-.	Nitrogen Dioxide	148-151	nitric oxide synthase 2	Rattus norvegicus	36-67
7542281-4	1995	The time course of the induction of inducible nitric oxide synthase (iNOS) protein in the pouch tissue was found to coincide with the production of NO2-.	Nitrogen Dioxide	148-151	nitric oxide synthase 2	Rattus norvegicus	69-73
7539274-3	1995	Under the same conditions, IL-4 and IL-10 reduced NO2-/NO3- generation.	Nitrogen Dioxide	50-53	interleukin 4	Rattus norvegicus	27-31
7539274-3	1995	Under the same conditions, IL-4 and IL-10 reduced NO2-/NO3- generation.	Nitrogen Dioxide	50-53	interleukin 10	Rattus norvegicus	36-41
7539274-9	1995	Finally, in the immune complex model of alveolitis, the appearance of iNOS in macrophages as well as macrophage production in vitro of NO2-/NO3- was dependent on the in vivo availability of tumor necrosis factor alpha, IL-1, and IFN-gamma.	Nitrogen Dioxide	135-138	tumor necrosis factor	Rattus norvegicus	190-217
7770723-3	1995	We found that IL-10 inhibited gamma interferon (IFN-gamma) priming for enhanced O2- release of mouse bone marrow-derived macrophages but had opposing effects on NO2- secretion according to the sequence of the treatment with IL-10 and the agonists of NO2- secretion.	Nitrogen Dioxide	161-164	interleukin 10	Mus musculus	14-19
7770723-3	1995	We found that IL-10 inhibited gamma interferon (IFN-gamma) priming for enhanced O2- release of mouse bone marrow-derived macrophages but had opposing effects on NO2- secretion according to the sequence of the treatment with IL-10 and the agonists of NO2- secretion.	Nitrogen Dioxide	250-253	interleukin 10	Mus musculus	14-19
7613114-6	1995	MCT was significantly increased after allergen challenge following exposure to both air and NO2.	Nitrogen Dioxide	92-95	tryptase delta 1	Homo sapiens	0-3
7613114-7	1995	In contrast, ECP was significantly increased by allergen challenge only after exposure to NO2.	Nitrogen Dioxide	90-93	ribonuclease A family member 3	Homo sapiens	13-16
7536940-8	1995	Moreover, the change in iNOS mRNA in the AM obtained from rats given MTB and MAC correlated with the production of the reactive nitrogen intermediates (RNI) NO2- and NO3- in BAL fluid, lung homogenate, and the spontaneous generation of RNI by isolated AM ex vivo and occurred without measurable increases in BAL fluid tumor necrosis factor-alpha (TNF-alpha).	Nitrogen Dioxide	157-160	nitric oxide synthase 2	Rattus norvegicus	24-28
7538104-8	1995	We detected inhibitory activity toward L1210 growth in serum of mice administered with hM-CSF, and the degree of the inhibitory activity was correlated with the level of nitrite (NO2-) in the serum.	Nitrogen Dioxide	179-183	colony stimulating factor 1	Homo sapiens	87-93
7538104-10	1995	The inhibition was abolished by the addition of NG-monomethyl-L-arginine, an inhibitor of NO2- synthesis, suggesting that the reactive nitrogen oxide intermediate is involved in hM-CSF-induced inhibition of L1210 growth.	Nitrogen Dioxide	90-93	colony stimulating factor 1	Homo sapiens	178-184
7589546-2	1995	NO production is induced in interferon-gamma and lipopolysaccharide stimulated RAW-264.7 macrophages as indicated by the increase of NO2- in the medium.	Nitrogen Dioxide	133-136	interferon gamma	Homo sapiens	28-44
7543752-2	1995	In the present study, we demonstrate that a combination (CL) of interleukin-1 alpha, interferon gamma, tumor necrosis factor alpha and lipopolysaccharide induces nitrite (NO2) production in cultured rat Sertoli cells.	Nitrogen Dioxide	171-174	interleukin 1 alpha	Rattus norvegicus	64-83
7634340-6	1995	PAF together with IFN-gamma stimulated macrophage secretion of NO2-.	Nitrogen Dioxide	63-66	PCNA clamp associated factor	Homo sapiens	0-3
7634340-6	1995	PAF together with IFN-gamma stimulated macrophage secretion of NO2-.	Nitrogen Dioxide	63-66	interferon gamma	Homo sapiens	18-27
7634340-7	1995	In addition, PAF enhanced IFN-gamma- and LPS-stimulated NO2- production.	Nitrogen Dioxide	56-59	PCNA clamp associated factor	Homo sapiens	13-16
7634340-7	1995	In addition, PAF enhanced IFN-gamma- and LPS-stimulated NO2- production.	Nitrogen Dioxide	56-59	interferon gamma	Homo sapiens	26-35
7626092-6	1995	Raising the O2 level will favor catalysis of NO oxidation to NO2 by CcO.	Nitrogen Dioxide	61-64	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	68-71
7554854-9	1995	(3) Generally, proximal alveolar region (PAR, a region of major morphological damage due to O3 and NO2) dose decreases the more distal the PAR.	Nitrogen Dioxide	99-102	plasminogen activator, urokinase receptor	Rattus norvegicus	41-44
7554854-9	1995	(3) Generally, proximal alveolar region (PAR, a region of major morphological damage due to O3 and NO2) dose decreases the more distal the PAR.	Nitrogen Dioxide	99-102	plasminogen activator, urokinase receptor	Rattus norvegicus	139-142
7538492-6	1995	The presence of IFN-gamma and LPS in the culture increased NO2- production by casein-elicited macrophages and partially eliminated the inhibition exerted by CsA and FK506.	Nitrogen Dioxide	59-62	interferon gamma	Mus musculus	16-25
7536858-3	1995	LPS, tumor necrosis factor-alpha (TNF-alpha) and the combination of both were able to induce NO synthesis in a dose-dependent manner as measured with the determination of NO2- levels.	Nitrogen Dioxide	171-174	tumor necrosis factor	Rattus norvegicus	34-43
7858061-2	1994	In addition to induce IgE production, IL-4 was found to elicit nitrite (NO2-) release by PBMC.	Nitrogen Dioxide	72-75	interleukin 4	Homo sapiens	38-42
7710100-1	1995	A new substrate for furin, Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(NO2)-Asp-OH, has been synthesized and characterized.	Nitrogen Dioxide	63-66	furin, paired basic amino acid cleaving enzyme	Homo sapiens	20-25
7524571-11	1994	Addition of IFN-gamma (250 to 500 IU/ml) synergistically enhanced the formation of NO2- induced by chrysotile and crocidolite.	Nitrogen Dioxide	83-86	interferon gamma	Rattus norvegicus	12-21
7834054-2	1994	The nitrogen dioxide-induced lipid peroxidation was enhanced by cysteine, glutathione and bovine serum albumin.	Nitrogen Dioxide	4-20	albumin	Homo sapiens	97-110
7834054-3	1994	While the activity of nitrogen dioxide in air to induce single strand breaks of supercoiled plasmid DNA was low, the breaking was remarkably enhanced by cysteine, glutathione and bovine serum albumin.	Nitrogen Dioxide	22-38	albumin	Homo sapiens	186-199
8660391-7	1995	It has been reported that O3 and .NO2 cause synergistic toxicity in rodents [Gielzleichter, Witschi and Last (1992) Tox.	Nitrogen Dioxide	34-37	thymocyte selection associated high mobility group box	Homo sapiens	116-119
7533135-4	1994	stimulated with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) showed increased cytotoxicity against L929 cells (TNF-alpha-sensitive), but were refractory for killing amoebae and P815 cells (both NO-sensitive), concomitant with low NO2- production (< 4 microM/10(6) cells).	Nitrogen Dioxide	243-246	interferon gamma	Mus musculus	16-32
7533135-4	1994	stimulated with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) showed increased cytotoxicity against L929 cells (TNF-alpha-sensitive), but were refractory for killing amoebae and P815 cells (both NO-sensitive), concomitant with low NO2- production (< 4 microM/10(6) cells).	Nitrogen Dioxide	243-246	interferon gamma	Mus musculus	34-43
7533135-6	1994	activated with IFN-gamma and LPS demonstrated increased killing of amoebae, and L929 and P815 cells concomitant with high NO2- production (> 12 microM/10(6) cells).	Nitrogen Dioxide	122-125	interferon gamma	Mus musculus	15-24
7921432-1	1994	The effects of ozone (O3) and nitrogen dioxide (NO2) on the solubility and proteolytic susceptibility of elastin were examined to better understand how these oxidant air pollutants might damage the lung.	Nitrogen Dioxide	30-46	elastin	Homo sapiens	105-112
7921432-1	1994	The effects of ozone (O3) and nitrogen dioxide (NO2) on the solubility and proteolytic susceptibility of elastin were examined to better understand how these oxidant air pollutants might damage the lung.	Nitrogen Dioxide	48-51	elastin	Homo sapiens	105-112
7921432-8	1994	In contrast, NO2-exposed elastin was no more susceptible to digestion by HNE.	Nitrogen Dioxide	13-16	elastin	Homo sapiens	25-32
7527875-8	1994	The induction of iNOS mRNA by LPS was markedly inhibited by actinomycin D and dexamethasone, as was the accumulation of NO2-/NO3- in the media.	Nitrogen Dioxide	120-123	nitric oxide synthase 2	Rattus norvegicus	17-21
7943255-7	1994	Intraperitoneal treatment with calphostin C (3 microM, 15 min prior to treatment with TNF) prevented the effects of TNF on 1) PKC activation, 2) the hemodynamic responses to U-46619, and 3) the levels of NO2- and O2(.).	Nitrogen Dioxide	204-207	tumor necrosis factor	Cavia porcellus	116-119
7943255-9	1994	The data suggest that PKC activation mediates TNF-induced 1) increases in O2., 2) decreases in NO2-, and 3) increases in vasoreactivity and edema in response to U-46619.	Nitrogen Dioxide	95-98	tumor necrosis factor	Cavia porcellus	46-49
7943258-3	1994	Compared with controls, an 18-h incubation with TNF (100 and 1,000 U/ml) resulted in a decrease in NO2- [the oxidation product of nitric oxide (NO)] in PAEM lysate and supernatant.	Nitrogen Dioxide	99-102	tumor necrosis factor	Bos taurus	48-51
7520469-4	1994	The inhibition of NO2- and NO3- release in mice injected with anti-tumor necrosis factor (TNF) and/or anti-interferon gamma (IFN-gamma) monoclonal antibody (mAb) before SEB challenge revealed that both cytokines were involved in SEB-induced NO overproduction.	Nitrogen Dioxide	18-21	tumor necrosis factor	Mus musculus	62-88
7517798-3	1994	METHODS AND RESULTS: We studied the effect of human recombinant interleukin-1 beta (IL-1 beta) on synthesis of NO2-/NO3- (NOx) and the expression of NOS mRNA and protein in cultured neonatal rat cardiocytes.	Nitrogen Dioxide	111-114	interleukin 1 beta	Homo sapiens	64-82
11550679-4	1994	As measured by the accumulation of NO2- in culture medium, NO production by IL-1-stimulated chondrocytes was inhibited by the NO synthase inhibitor Ng-monomethyl-L-arginine (NMA) and dependent on the presence of exogenous L-arginine.	Nitrogen Dioxide	35-38	interleukin 1 beta	Homo sapiens	76-80
7985808-1	1994	The preparation and substrate properties of the fluorogenic insulin derivative N alpha A1-aminobenzoyl-N epilson B29-Tyr(NO2)- insulin are described.	Nitrogen Dioxide	121-124	insulin	Homo sapiens	60-67
7985808-1	1994	The preparation and substrate properties of the fluorogenic insulin derivative N alpha A1-aminobenzoyl-N epilson B29-Tyr(NO2)- insulin are described.	Nitrogen Dioxide	121-124	insulin	Homo sapiens	127-134
8034046-7	1994	Peroxynitrite (ONOO-) also induces GAPDH modification in the presence of thiol, consistent with the notion that this species can transfer NO+ (or NO2+) through the intermediacy of RS-NO.	Nitrogen Dioxide	146-150	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	35-40
7953244-5	1994	The production of NO2- by TNF-alpha-, IFN-gamma- or IFN-gamma/TNF-alpha-treated macrophages from Toxoplasma-infected mice were significantly higher than that by resident macrophages, whereas lymphokine-treated group produced similar amount as that produced by resident macrophages.	Nitrogen Dioxide	18-21	tumor necrosis factor	Mus musculus	26-35
7953244-5	1994	The production of NO2- by TNF-alpha-, IFN-gamma- or IFN-gamma/TNF-alpha-treated macrophages from Toxoplasma-infected mice were significantly higher than that by resident macrophages, whereas lymphokine-treated group produced similar amount as that produced by resident macrophages.	Nitrogen Dioxide	18-21	interferon gamma	Mus musculus	38-47
7953244-5	1994	The production of NO2- by TNF-alpha-, IFN-gamma- or IFN-gamma/TNF-alpha-treated macrophages from Toxoplasma-infected mice were significantly higher than that by resident macrophages, whereas lymphokine-treated group produced similar amount as that produced by resident macrophages.	Nitrogen Dioxide	18-21	interferon gamma	Mus musculus	52-61
7953244-5	1994	The production of NO2- by TNF-alpha-, IFN-gamma- or IFN-gamma/TNF-alpha-treated macrophages from Toxoplasma-infected mice were significantly higher than that by resident macrophages, whereas lymphokine-treated group produced similar amount as that produced by resident macrophages.	Nitrogen Dioxide	18-21	tumor necrosis factor	Mus musculus	62-71
7953244-7	1994	IFN-gamma-treated macrophages were significantly increased production of H2O2 and NO2-, and anti-Toxoplasma activities of macrophages between normal and Toxoplasma-infected mice, whereas the other cytokine-treated groups were not significant differences between them.	Nitrogen Dioxide	82-85	interferon gamma	Mus musculus	0-9
7517798-3	1994	METHODS AND RESULTS: We studied the effect of human recombinant interleukin-1 beta (IL-1 beta) on synthesis of NO2-/NO3- (NOx) and the expression of NOS mRNA and protein in cultured neonatal rat cardiocytes.	Nitrogen Dioxide	111-114	interleukin 1 beta	Homo sapiens	84-93
7928304-11	1994	Moreover, LAP1 was capable of inducing NO2- production in SPs.	Nitrogen Dioxide	39-42	torsin A interacting protein 1	Mus musculus	10-14
7514189-4	1994	NG-monomethyl-L-arginine (L-NMMA), which blocks the activity of both constitutive and inducible nitric oxide synthase (cNOS and iNOS), aminoguanidine, a recently described selective iNOS inhibitor, dexamethasone, or cycloheximide abolished the release of NO2- and attenuated the exaggerated BK-induced PGE2 production.	Nitrogen Dioxide	255-258	nitric oxide synthase, inducible	Oryctolagus cuniculus	86-117
7959883-3	1994	We have discovered that there is a significant difference in the production of NO2- of B10S compared with B10R macrophages in response to IFN-gamma.	Nitrogen Dioxide	79-82	interferon gamma	Mus musculus	138-147
7959883-4	1994	By 48 hr following treatment with 10 U/ml IFN-gamma, B10R macrophages had produced an approximately threefold higher level of NO2- than B10S macrophages.	Nitrogen Dioxide	126-129	interferon gamma	Mus musculus	42-51
7959883-10	1994	Northern blot analysis of macrophage nitric oxide synthase (iNOS) revealed that the difference in NO2- production by IFN-gamma-treated B10S and B10R lines was reflective of the difference in iNOS mRNA expression.	Nitrogen Dioxide	98-101	nitric oxide synthase 2, inducible	Mus musculus	60-64
7959883-10	1994	Northern blot analysis of macrophage nitric oxide synthase (iNOS) revealed that the difference in NO2- production by IFN-gamma-treated B10S and B10R lines was reflective of the difference in iNOS mRNA expression.	Nitrogen Dioxide	98-101	interferon gamma	Mus musculus	117-126
8003032-2	1994	TNF alpha, IL-1 beta, and LPS caused a dose- and time-dependent increase of nitrite (NO2-), the stable metabolite of nitric oxide (NO), in conditioned media over 48 hours, while IFN gamma had a minimal effect.	Nitrogen Dioxide	85-88	tumor necrosis factor	Mus musculus	0-9
8003032-2	1994	TNF alpha, IL-1 beta, and LPS caused a dose- and time-dependent increase of nitrite (NO2-), the stable metabolite of nitric oxide (NO), in conditioned media over 48 hours, while IFN gamma had a minimal effect.	Nitrogen Dioxide	85-88	interleukin 1 beta	Mus musculus	11-20
8202945-5	1994	NO2 alone suppresses drastically the release of TNF-alpha.	Nitrogen Dioxide	0-3	tumor necrosis factor	Bos taurus	48-57
7925190-4	1994	Similar alterations in various aspects of mucin biochemistry and biophysics, leading to mucus hypersecretion and altered mucus rheology, result from inhalation of certain air pollutants, such as ozone, sulfur dioxide, nitrogen dioxide, and cigarette smoke.	Nitrogen Dioxide	218-234	LOC100508689	Homo sapiens	42-47
8198585-3	1994	Addition of NO3- caused the greatest increase in NO2- production when macrophages were primed with interferon-gamma (INF-gamma) and lipopolysaccharide (LPS).	Nitrogen Dioxide	49-52	NBL1, DAN family BMP antagonist	Mus musculus	12-15
8198585-3	1994	Addition of NO3- caused the greatest increase in NO2- production when macrophages were primed with interferon-gamma (INF-gamma) and lipopolysaccharide (LPS).	Nitrogen Dioxide	49-52	interferon gamma	Mus musculus	99-115
8198585-3	1994	Addition of NO3- caused the greatest increase in NO2- production when macrophages were primed with interferon-gamma (INF-gamma) and lipopolysaccharide (LPS).	Nitrogen Dioxide	49-52	interferon gamma	Mus musculus	117-126
7514114-3	1994	When treated with the proinflammatory cytokines IFN-gamma, TNF-alpha, and IL-1 alpha, these fibroblast lines produce micromolar quantities of NO2- and NO3-, two stable end products of the NO pathway.	Nitrogen Dioxide	142-145	interferon gamma	Mus musculus	48-57
7514114-3	1994	When treated with the proinflammatory cytokines IFN-gamma, TNF-alpha, and IL-1 alpha, these fibroblast lines produce micromolar quantities of NO2- and NO3-, two stable end products of the NO pathway.	Nitrogen Dioxide	142-145	tumor necrosis factor	Mus musculus	59-68
7514114-3	1994	When treated with the proinflammatory cytokines IFN-gamma, TNF-alpha, and IL-1 alpha, these fibroblast lines produce micromolar quantities of NO2- and NO3-, two stable end products of the NO pathway.	Nitrogen Dioxide	142-145	interleukin 1 alpha	Mus musculus	74-84
7510778-6	1994	This is confirmed by the finding that the culture supernatants of N103 cells induced by TNF-alpha and IFN-gamma, but not that by IL-6, contained high levels of NO2-, the production of which was inhibited by L-NG-monomethylarginine.	Nitrogen Dioxide	160-163	tumor necrosis factor	Homo sapiens	88-97
7510778-6	1994	This is confirmed by the finding that the culture supernatants of N103 cells induced by TNF-alpha and IFN-gamma, but not that by IL-6, contained high levels of NO2-, the production of which was inhibited by L-NG-monomethylarginine.	Nitrogen Dioxide	160-163	interferon gamma	Homo sapiens	102-111
7520406-5	1994	When nitrogen dioxide was exposed to a solution of bovine serum albumin, human gamma-globulin and bovine eye lens alpha-crystallin, the proteins were crosslinked by nondisulfide bonds.	Nitrogen Dioxide	5-21	albumin	Homo sapiens	58-71
8140629-8	1994	Measurement of plasma nitrite (NO2-) and nitrate (NO3-), which are the stable end products of NO, revealed that NO2- decreased about 50% after reperfusion (from 1.64 +/- 0.32 mumol/L to 0.80 +/- 0.17 mumol/L; P < 0.001), whereas NO3- levels remained unchanged (76 +/- 23 mumol/L vs. 63 +/- 8 mumol/L).	Nitrogen Dioxide	112-115	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
8140629-8	1994	Measurement of plasma nitrite (NO2-) and nitrate (NO3-), which are the stable end products of NO, revealed that NO2- decreased about 50% after reperfusion (from 1.64 +/- 0.32 mumol/L to 0.80 +/- 0.17 mumol/L; P < 0.001), whereas NO3- levels remained unchanged (76 +/- 23 mumol/L vs. 63 +/- 8 mumol/L).	Nitrogen Dioxide	112-115	NBL1, DAN family BMP antagonist	Homo sapiens	232-235
8027589-3	1994	NO2- production by macrophages in culture was slightly inhibited (about 16%) at 30 nM IFN-alpha and a clear decrease (35%) was obtained with 150 nM IFN-alpha.	Nitrogen Dioxide	0-3	interferon alpha 1	Homo sapiens	86-95
8300224-4	1994	An increase in levels of NO2-, an end product of L-Arg metabolism, was detected only after activation of RAW 264.7 cells to the growth-inhibitory state.	Nitrogen Dioxide	25-28	Rho guanine nucleotide exchange factor (GEF) 12	Mus musculus	49-54
8300224-5	1994	In contrast, only baseline levels of NO2- were detected when L-Arg was excluded or when NG-monomethyl-L-Arg was added to the culture medium.	Nitrogen Dioxide	37-40	Rho guanine nucleotide exchange factor (GEF) 12	Mus musculus	61-66
8300224-5	1994	In contrast, only baseline levels of NO2- were detected when L-Arg was excluded or when NG-monomethyl-L-Arg was added to the culture medium.	Nitrogen Dioxide	37-40	Rho guanine nucleotide exchange factor (GEF) 12	Mus musculus	102-107
7509342-1	1994	By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs).	Nitrogen Dioxide	19-22	nitric oxide synthase 2	Rattus norvegicus	173-204
8027589-3	1994	NO2- production by macrophages in culture was slightly inhibited (about 16%) at 30 nM IFN-alpha and a clear decrease (35%) was obtained with 150 nM IFN-alpha.	Nitrogen Dioxide	0-3	interferon alpha 1	Homo sapiens	148-157
8228620-2	1993	TGF-beta, added simultaneously with or up to 4 h before interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS), inhibited macrophage leishmanicidal activity, nitrite (NO2-) production, and secretion of prostaglandin E2.	Nitrogen Dioxide	171-175	transforming growth factor, beta 1	Mus musculus	0-8
8301214-7	1994	Moreover, treatment of MDM with gp120 for 15 h increased in a dose-dependent manner the production of NO2-, a stable end product of NO.	Nitrogen Dioxide	102-105	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	32-37
8277172-2	1994	Normal mouse plasma amplified NO synthesis (measured as NO2- release) at LPS concentrations of 1-10 ng/mL, and antibody to the plasma LPS-binding protein (LBP) partially inhibited NO2- release in the presence of normal mouse plasma.	Nitrogen Dioxide	56-59	lipopolysaccharide binding protein	Mus musculus	155-158
8277172-2	1994	Normal mouse plasma amplified NO synthesis (measured as NO2- release) at LPS concentrations of 1-10 ng/mL, and antibody to the plasma LPS-binding protein (LBP) partially inhibited NO2- release in the presence of normal mouse plasma.	Nitrogen Dioxide	180-183	lipopolysaccharide binding protein	Mus musculus	134-153
8277172-2	1994	Normal mouse plasma amplified NO synthesis (measured as NO2- release) at LPS concentrations of 1-10 ng/mL, and antibody to the plasma LPS-binding protein (LBP) partially inhibited NO2- release in the presence of normal mouse plasma.	Nitrogen Dioxide	180-183	lipopolysaccharide binding protein	Mus musculus	155-158
8277172-4	1994	Fifty percent inhibition of IFN-gamma/LPS-elicited NO2- production or of binding of fluoresceinated LPS was obtained with approximately 0.2 microgram/mL rBPI23.	Nitrogen Dioxide	51-54	interferon gamma	Mus musculus	28-37
8269547-3	1993	Qualitatively they result in separation of the initial irreversible 4 electron reduction into two stages, the NO2/RNO2.- and RNO2.-, 4H/RNHOH, H2O couples, respectively.	Nitrogen Dioxide	110-113	NLR family pyrin domain containing 12	Homo sapiens	114-118
8238533-4	1993	The vascular effects of TNF were associated with 1) decreased lung effluent nitrite (NO2-, oxidation product of nitric oxide), 2) increased lung effluent superoxide (O2-), and 3) increased lung myeloperoxidase (MPO).	Nitrogen Dioxide	85-88	tumor necrosis factor	Cavia porcellus	24-27
8238533-5	1993	Superoxide dismutase (SOD, 10 U/ml) prevented 1) the effects of TNF on the hemodynamic responses to U-46619 and ACh and 2) the TNF-induced decrease in NO2-.	Nitrogen Dioxide	151-154	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	0-20
8238533-5	1993	Superoxide dismutase (SOD, 10 U/ml) prevented 1) the effects of TNF on the hemodynamic responses to U-46619 and ACh and 2) the TNF-induced decrease in NO2-.	Nitrogen Dioxide	151-154	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	22-25
8238533-5	1993	Superoxide dismutase (SOD, 10 U/ml) prevented 1) the effects of TNF on the hemodynamic responses to U-46619 and ACh and 2) the TNF-induced decrease in NO2-.	Nitrogen Dioxide	151-154	tumor necrosis factor	Cavia porcellus	127-130
7507664-5	1994	Bacteria-induced NO2- production was enhanced by concomittant exposure to interferon-gamma, tumor necrosis factor-alpha or both combined, although these cytokines alone (in the absence of bacteria) induced little NO2-.	Nitrogen Dioxide	17-20	interferon gamma	Bos taurus	74-119
8292382-5	1994	IFN-gamma (1,000 U)-induced increases in lambda 0 were concentration-dependently inhibited by NG-monomethyl-L-arginine (L-NMMA) with complete inhibition of a concentration of 10(-4) M and were also completely inhibited by either methylene blue (10(-5) M) or KT 5823 (10(-5) M), a specific inhibitor of protein kinase G. IFN-gamma (1,000 U) caused significant nitrite (NO2-) production from the control values of 0.2 +/- 0.1 to 10.0 +/- 0.2 microM/24 h per 10(6) cells (P < 0.001, n = 10), and this increase in NO2- production by IFN-gamma (1,000 U) was completely inhibited by L-NMMA (10(-4) M).	Nitrogen Dioxide	368-371	interferon gamma	Rattus norvegicus	0-9
7504482-3	1993	The addition of aminoguanidine (1 mM), a preferential inhibitor of the inducible NO-synthase, completely abolished NO2-accumulation.	Nitrogen Dioxide	115-118	nitric oxide synthase 2	Rattus norvegicus	71-92
8228620-5	1993	Interestingly, when macrophages were pretreated with TGF-beta for 24 h, NO2- production in response to IFN-gamma plus TNF-alpha was also inhibited.	Nitrogen Dioxide	72-75	transforming growth factor, beta 1	Mus musculus	53-61
8228620-5	1993	Interestingly, when macrophages were pretreated with TGF-beta for 24 h, NO2- production in response to IFN-gamma plus TNF-alpha was also inhibited.	Nitrogen Dioxide	72-75	interferon gamma	Mus musculus	103-112
8228620-5	1993	Interestingly, when macrophages were pretreated with TGF-beta for 24 h, NO2- production in response to IFN-gamma plus TNF-alpha was also inhibited.	Nitrogen Dioxide	72-75	tumor necrosis factor	Mus musculus	118-127
7689037-2	1993	NO production, as indicated by NO2- in the culture medium, was increased in cells initiated with 3-methylcholanthrene or stimulated with the combination of interferon-gamma (IFN gamma, 10 ng/ml) plus bacterial lipopolysaccharide (LPS, 1 micrograms/ml).	Nitrogen Dioxide	31-34	interferon gamma	Mus musculus	156-172
8399089-8	1993	Significantly higher NO2 production in response to interferon gamma was found, both after 6 and 15 weeks of diet feeding, in the menhaden group compared with the control group.	Nitrogen Dioxide	21-24	interferon gamma	Mus musculus	51-67
8370073-7	1993	Addition of 1 to 50 U/ml IFN-gamma induced a dose-dependent increase in NO2- production, with the maximal level approximating that found in suppressed cocultures; TNF-alpha, IL-2, or LPS did not synergize with IFN-gamma to enhance NO2- production.	Nitrogen Dioxide	72-75	interferon gamma	Rattus norvegicus	25-34
8370073-7	1993	Addition of 1 to 50 U/ml IFN-gamma induced a dose-dependent increase in NO2- production, with the maximal level approximating that found in suppressed cocultures; TNF-alpha, IL-2, or LPS did not synergize with IFN-gamma to enhance NO2- production.	Nitrogen Dioxide	231-234	interferon gamma	Rattus norvegicus	25-34
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	Nitrogen Dioxide	56-61	interleukin 1 beta	Mus musculus	0-18
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	Nitrogen Dioxide	56-61	interleukin 1 beta	Mus musculus	20-29
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	Nitrogen Dioxide	56-61	interleukin 1 beta	Mus musculus	182-191
8134178-1	1993	In a rat model of fatal infection caused by Pseudomonas aeruginosa, the circulating level of nitrite/nitrate (NO2-/NO3-), a good indicator for nitric oxide production, was remarkably increased after elevation of circulatory tumor necrosis factor (TNF).	Nitrogen Dioxide	110-113	tumor necrosis factor-like	Rattus norvegicus	224-245
8134178-1	1993	In a rat model of fatal infection caused by Pseudomonas aeruginosa, the circulating level of nitrite/nitrate (NO2-/NO3-), a good indicator for nitric oxide production, was remarkably increased after elevation of circulatory tumor necrosis factor (TNF).	Nitrogen Dioxide	110-113	tumor necrosis factor-like	Rattus norvegicus	247-250
8134178-3	1993	Moreover, anti-TNF MAb significantly reduced not only plasma TNF but also plasma NO2-/NO3- levels.	Nitrogen Dioxide	81-84	tumor necrosis factor-like	Rattus norvegicus	15-18
7688393-4	1993	In this study, we determined which mediator from cutaneous mast cells mediates substance P-induced granulocyte infiltration in the skin by the use of two mediator antagonists; one for platelet activating factor (PAF) CV-6209 and the other for leukotriene B4 (LTB4) ONO-4057.	Nitrogen Dioxide	265-268	tachykinin 1	Mus musculus	79-90
8342914-4	1993	Biochemical findings in animals exposed to ozone and nitrogen dioxide included increased lung content of DNA, protein, collagen, and elastin, which was about 300% higher than the control values.	Nitrogen Dioxide	53-69	elastin	Rattus norvegicus	133-140
7689037-2	1993	NO production, as indicated by NO2- in the culture medium, was increased in cells initiated with 3-methylcholanthrene or stimulated with the combination of interferon-gamma (IFN gamma, 10 ng/ml) plus bacterial lipopolysaccharide (LPS, 1 micrograms/ml).	Nitrogen Dioxide	31-34	interferon gamma	Mus musculus	174-183
7689037-3	1993	NO2- was detectable within 24-48 h of IFN gamma/LPS treatment and accumulated to micromolar concentrations within 4 days.	Nitrogen Dioxide	0-3	interferon gamma	Mus musculus	38-47
8102159-4	1993	Stimuli such as PMA, LPS, and/or IFN-gamma induce micromolar concentrations of NO2- within 24 h. TNF-alpha increases IFN gamma but not LPS-induced NO2- production.	Nitrogen Dioxide	79-82	interferon gamma	Rattus norvegicus	33-42
7688311-3	1993	Under these conditions and in contrast to its reported deactivating potential, IL-10 strongly enhanced NO synthesis measured as nitrite (NO2-) release (half maximal stimulation at approximately 10 U/ml).	Nitrogen Dioxide	137-140	interleukin 10	Homo sapiens	79-84
8102159-4	1993	Stimuli such as PMA, LPS, and/or IFN-gamma induce micromolar concentrations of NO2- within 24 h. TNF-alpha increases IFN gamma but not LPS-induced NO2- production.	Nitrogen Dioxide	79-82	tumor necrosis factor	Rattus norvegicus	97-106
8102159-4	1993	Stimuli such as PMA, LPS, and/or IFN-gamma induce micromolar concentrations of NO2- within 24 h. TNF-alpha increases IFN gamma but not LPS-induced NO2- production.	Nitrogen Dioxide	79-82	interferon gamma	Rattus norvegicus	117-126
8102159-4	1993	Stimuli such as PMA, LPS, and/or IFN-gamma induce micromolar concentrations of NO2- within 24 h. TNF-alpha increases IFN gamma but not LPS-induced NO2- production.	Nitrogen Dioxide	147-150	tumor necrosis factor	Rattus norvegicus	97-106
8102159-6	1993	NO2- production is inhibited by NO synthase antagonists, transforming growth factor-beta, and anti TNF-alpha.	Nitrogen Dioxide	0-3	tumor necrosis factor	Rattus norvegicus	99-108
8102159-8	1993	Indeed, anti-ICAM-1 treatment increases NO2- production.	Nitrogen Dioxide	40-43	intercellular adhesion molecule 1	Rattus norvegicus	13-19
7688311-4	1993	IL-10 further increased NO2- production by M phi stimulated in the presence of optimal concentrations of prostaglandin E2, a positive modulator of M phi activation by IFN-gamma/TNF-alpha.	Nitrogen Dioxide	24-27	interleukin 10	Homo sapiens	0-5
7688311-4	1993	IL-10 further increased NO2- production by M phi stimulated in the presence of optimal concentrations of prostaglandin E2, a positive modulator of M phi activation by IFN-gamma/TNF-alpha.	Nitrogen Dioxide	24-27	interferon gamma	Homo sapiens	167-176
7688311-4	1993	IL-10 further increased NO2- production by M phi stimulated in the presence of optimal concentrations of prostaglandin E2, a positive modulator of M phi activation by IFN-gamma/TNF-alpha.	Nitrogen Dioxide	24-27	tumor necrosis factor	Homo sapiens	177-186
7688473-2	1993	Induction of NO synthase (NOS) and COX (COX-2) in the mouse macrophage cell line RAW264.7 by Escherichia coli lipopolysaccharide (1 microgram/ml, 18 h) caused an increase in the release of nitrite (NO2-) and prostaglandin E2 (PGE2), products of NOS and COX, respectively.	Nitrogen Dioxide	198-201	nitric oxide synthase 1, neuronal	Mus musculus	13-24
7688473-2	1993	Induction of NO synthase (NOS) and COX (COX-2) in the mouse macrophage cell line RAW264.7 by Escherichia coli lipopolysaccharide (1 microgram/ml, 18 h) caused an increase in the release of nitrite (NO2-) and prostaglandin E2 (PGE2), products of NOS and COX, respectively.	Nitrogen Dioxide	198-201	cytochrome c oxidase II, mitochondrial	Mus musculus	40-45
8323282-2	1993	In order to gain information on the mechanism by which NO2 damages the lung and proteins vital to its function, as well as its reaction with proteins in general, in vitro exposures of alpha-1-proteinase inhibitor (alpha 1PI), elastin, poly-L-lysine, and poly-L-arginine were performed.	Nitrogen Dioxide	55-58	elastin	Homo sapiens	226-233
7688152-4	1993	METHODS: RPASM, preincubated in the presence of antisense and sense oligodeoxynucleotide to the first 18 bases after the initiation codon of iNOS mRNA, was exposed to interferon-gamma and tumor necrosis factor-alpha to induce NO production (as measured by NO2-, the stable end product of NO formation).	Nitrogen Dioxide	256-259	interferon gamma	Rattus norvegicus	167-215
7688152-5	1993	RESULTS: Interferon-gamma and tumor necrosis factor-alpha induced NO production in RPASM: The antisense probe caused up to a 36% decrease in cytokine-induced NO2- production in a concentration-dependent manner (1 to 10 mumol/L).	Nitrogen Dioxide	158-161	interferon gamma	Rattus norvegicus	9-57
8341679-5	1993	The stimulatory actions of IFN-alpha/beta on NO2- release were indistinguishable in wild-type and IFN-gamma R0/0 macrophages: IFN-alpha/beta was ineffective on its own, showed marginal stimulation of NO2- release in combination with TNF, and was moderately effective in the presence of lipopolysaccharide.	Nitrogen Dioxide	45-48	interferon alpha	Mus musculus	27-36
8323282-6	1993	Elastin and poly-L-lysine were labeled by reductive methylation of amino groups with [3H]HCHO prior to treatment with NO2 in aqueous solutions at physiological pH.	Nitrogen Dioxide	118-121	elastin	Homo sapiens	0-7
8323282-7	1993	NO2 exposure of elastin resulted in the solubilization of 84% of the associated radioactivity of which 79% was identified as [3H]methyllysine by amino acid analysis.	Nitrogen Dioxide	0-3	elastin	Homo sapiens	16-23
7681038-4	1993	Like M phi, these clones were found to release high levels of NO2- in response to recombinant interferon-gamma (rIFN-gamma) as a priming signal together with either bacterial lipopolysaccharide (LPS) or exogenous recombinant tumor necrosis factor-alpha (rTNF-alpha).	Nitrogen Dioxide	62-65	interferon gamma	Mus musculus	94-110
8473748-2	1993	ANA-1 macrophages did not produce nitrite (NO2-) constitutively, but accumulated detectable levels of NO2- on exposure to IFN-gamma.	Nitrogen Dioxide	102-105	interferon gamma	Mus musculus	122-131
8473748-3	1993	Picolinic acid, although ineffective by itself, augmented IFN-gamma-induced NO2- production.	Nitrogen Dioxide	76-79	interferon gamma	Mus musculus	58-67
8473748-6	1993	Neutralizing concentrations of anti-TNF mAb completely abrogated IFN-gamma- and IFN-gamma plus rTNF-alpha-induced NO2- production in ANA-1 macrophages, but only decreased by approximately 50% the synergistic interaction between IFN-gamma and picolinic acid.	Nitrogen Dioxide	114-117	tumor necrosis factor	Mus musculus	36-39
8473748-6	1993	Neutralizing concentrations of anti-TNF mAb completely abrogated IFN-gamma- and IFN-gamma plus rTNF-alpha-induced NO2- production in ANA-1 macrophages, but only decreased by approximately 50% the synergistic interaction between IFN-gamma and picolinic acid.	Nitrogen Dioxide	114-117	interferon gamma	Mus musculus	65-74
8473748-6	1993	Neutralizing concentrations of anti-TNF mAb completely abrogated IFN-gamma- and IFN-gamma plus rTNF-alpha-induced NO2- production in ANA-1 macrophages, but only decreased by approximately 50% the synergistic interaction between IFN-gamma and picolinic acid.	Nitrogen Dioxide	114-117	interferon gamma	Mus musculus	80-89
8473748-6	1993	Neutralizing concentrations of anti-TNF mAb completely abrogated IFN-gamma- and IFN-gamma plus rTNF-alpha-induced NO2- production in ANA-1 macrophages, but only decreased by approximately 50% the synergistic interaction between IFN-gamma and picolinic acid.	Nitrogen Dioxide	114-117	tumor necrosis factor	Rattus norvegicus	95-105
8473748-6	1993	Neutralizing concentrations of anti-TNF mAb completely abrogated IFN-gamma- and IFN-gamma plus rTNF-alpha-induced NO2- production in ANA-1 macrophages, but only decreased by approximately 50% the synergistic interaction between IFN-gamma and picolinic acid.	Nitrogen Dioxide	114-117	interferon gamma	Mus musculus	80-89
8473748-7	1993	Although IL-4 inhibited the expression of IFN-gamma plus picolinic acid-induced TNF-alpha mRNA and protein, it only partially suppressed picolinic acid-dependent NO2- production.	Nitrogen Dioxide	162-165	interleukin 4	Mus musculus	9-13
8473748-8	1993	Therefore, picolinic acid may affect NO2- production via both TNF-alpha-dependent and TNF-alpha-independent pathways.	Nitrogen Dioxide	37-40	tumor necrosis factor	Mus musculus	62-71
8473748-8	1993	Therefore, picolinic acid may affect NO2- production via both TNF-alpha-dependent and TNF-alpha-independent pathways.	Nitrogen Dioxide	37-40	tumor necrosis factor	Mus musculus	86-95
7682068-3	1993	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-).	Nitrogen Dioxide	149-152	nitric oxide synthase 2	Rattus norvegicus	0-31
7682068-3	1993	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-).	Nitrogen Dioxide	149-152	nitric oxide synthase 2	Rattus norvegicus	33-37
7686532-3	1993	Interleukin-1 beta dose dependently (1 to 20 ng/mL) stimulated NO2-/NO3- production as a function of time.	Nitrogen Dioxide	63-66	interleukin 1 beta	Rattus norvegicus	0-18
7686532-5	1993	NG-Monomethyl L-arginine completely blocked the interleukin-1 beta-induced NO2-/NO3- production, the effect of which was reversed by L-arginine but not by D-arginine.	Nitrogen Dioxide	75-78	interleukin 1 beta	Rattus norvegicus	48-66
8366624-4	1993	Cytolysis, TNF activity and NO2- production were enhanced by lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma).	Nitrogen Dioxide	28-31	interferon gamma	Mus musculus	90-106
8366624-4	1993	Cytolysis, TNF activity and NO2- production were enhanced by lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma).	Nitrogen Dioxide	28-31	interferon gamma	Mus musculus	108-117
7681038-4	1993	Like M phi, these clones were found to release high levels of NO2- in response to recombinant interferon-gamma (rIFN-gamma) as a priming signal together with either bacterial lipopolysaccharide (LPS) or exogenous recombinant tumor necrosis factor-alpha (rTNF-alpha).	Nitrogen Dioxide	62-65	interferon gamma	Rattus norvegicus	112-122
7681038-4	1993	Like M phi, these clones were found to release high levels of NO2- in response to recombinant interferon-gamma (rIFN-gamma) as a priming signal together with either bacterial lipopolysaccharide (LPS) or exogenous recombinant tumor necrosis factor-alpha (rTNF-alpha).	Nitrogen Dioxide	62-65	tumor necrosis factor	Mus musculus	225-252
7681038-4	1993	Like M phi, these clones were found to release high levels of NO2- in response to recombinant interferon-gamma (rIFN-gamma) as a priming signal together with either bacterial lipopolysaccharide (LPS) or exogenous recombinant tumor necrosis factor-alpha (rTNF-alpha).	Nitrogen Dioxide	62-65	tumor necrosis factor	Rattus norvegicus	254-264
8423095-2	1993	Both NO2- production and inhibition of bacterial growth were suppressed by NG-monomethyl-L-arginine, a substrate inhibitor of nitrogen oxidation of L-arginine, and monoclonal antibodies (MAbs) to gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha).	Nitrogen Dioxide	5-8	interferon gamma	Mus musculus	196-223
8423095-2	1993	Both NO2- production and inhibition of bacterial growth were suppressed by NG-monomethyl-L-arginine, a substrate inhibitor of nitrogen oxidation of L-arginine, and monoclonal antibodies (MAbs) to gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha).	Nitrogen Dioxide	5-8	tumor necrosis factor	Mus musculus	229-256
8423095-2	1993	Both NO2- production and inhibition of bacterial growth were suppressed by NG-monomethyl-L-arginine, a substrate inhibitor of nitrogen oxidation of L-arginine, and monoclonal antibodies (MAbs) to gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha).	Nitrogen Dioxide	5-8	tumor necrosis factor	Mus musculus	258-267
1478682-2	1992	A single intravenous injection of 1 x 10(6) U or three injections of 2 x 10(5) U recombinant IFN-gamma (rIFN-gamma) induced optimal activation of resident and exudate peritoneal macrophages, as judged by their ability to inhibit the intracellular proliferation of Toxoplasma gondii and their enhanced release of H2O2 and NO2-.	Nitrogen Dioxide	321-324	interferon gamma	Rattus norvegicus	93-102
1431106-5	1992	As observed previously with ANA-1 macrophage tumoricidal activity, IL-4 inhibited IFN-gamma plus IL-2-induced, but not IFN-gamma plus LPS-induced, NO2- production.	Nitrogen Dioxide	147-150	interleukin 4	Mus musculus	67-71
1431106-7	1992	Lastly, incubation of ANA-1 macrophages with anti-TNF mAb selectively inhibited the ability of IFN-gamma plus IL-2 to induce NO2- production and tumoricidal activity.	Nitrogen Dioxide	125-128	tumor necrosis factor	Mus musculus	50-53
1431106-7	1992	Lastly, incubation of ANA-1 macrophages with anti-TNF mAb selectively inhibited the ability of IFN-gamma plus IL-2 to induce NO2- production and tumoricidal activity.	Nitrogen Dioxide	125-128	interferon gamma	Mus musculus	95-104
1431106-7	1992	Lastly, incubation of ANA-1 macrophages with anti-TNF mAb selectively inhibited the ability of IFN-gamma plus IL-2 to induce NO2- production and tumoricidal activity.	Nitrogen Dioxide	125-128	interleukin 2	Mus musculus	110-114
1431106-8	1992	These results indicate that IFN-gamma plus IL-2-induced tumoricidal activity is dependent upon the metabolism of L-arginine to reactive nitrogen intermediates, and they establish a role for TNF-alpha as a required intermediate for IL-2-dependent NO2- production and tumoricidal activity.	Nitrogen Dioxide	246-249	interferon gamma	Mus musculus	28-37
1431106-8	1992	These results indicate that IFN-gamma plus IL-2-induced tumoricidal activity is dependent upon the metabolism of L-arginine to reactive nitrogen intermediates, and they establish a role for TNF-alpha as a required intermediate for IL-2-dependent NO2- production and tumoricidal activity.	Nitrogen Dioxide	246-249	interleukin 2	Mus musculus	43-47
1431106-8	1992	These results indicate that IFN-gamma plus IL-2-induced tumoricidal activity is dependent upon the metabolism of L-arginine to reactive nitrogen intermediates, and they establish a role for TNF-alpha as a required intermediate for IL-2-dependent NO2- production and tumoricidal activity.	Nitrogen Dioxide	246-249	tumor necrosis factor	Mus musculus	190-199
1431106-8	1992	These results indicate that IFN-gamma plus IL-2-induced tumoricidal activity is dependent upon the metabolism of L-arginine to reactive nitrogen intermediates, and they establish a role for TNF-alpha as a required intermediate for IL-2-dependent NO2- production and tumoricidal activity.	Nitrogen Dioxide	246-249	interleukin 2	Mus musculus	231-235
1452344-3	1992	After an intraperitoneal injection of rIFN-gamma into CBA/J mice, their peritoneal macrophages released enhanced amounts of NO2- and inhibited the intracellular proliferation of Toxoplasma gondii.	Nitrogen Dioxide	124-127	interferon gamma	Rattus norvegicus	38-48
1452344-4	1992	Injection of neutralizing antibodies against TNF-alpha simultaneously with the rIFN-gamma completely inhibited both the release of NO2- by macrophages and their toxoplasmastatic activity.	Nitrogen Dioxide	131-134	tumor necrosis factor	Mus musculus	45-54
1452344-4	1992	Injection of neutralizing antibodies against TNF-alpha simultaneously with the rIFN-gamma completely inhibited both the release of NO2- by macrophages and their toxoplasmastatic activity.	Nitrogen Dioxide	131-134	interferon gamma	Rattus norvegicus	79-89
1478682-2	1992	A single intravenous injection of 1 x 10(6) U or three injections of 2 x 10(5) U recombinant IFN-gamma (rIFN-gamma) induced optimal activation of resident and exudate peritoneal macrophages, as judged by their ability to inhibit the intracellular proliferation of Toxoplasma gondii and their enhanced release of H2O2 and NO2-.	Nitrogen Dioxide	321-324	interferon gamma	Rattus norvegicus	104-114
1404242-1	1992	We recently reported that nitrogen dioxide (NO2), an environmental oxidant, alters the dynamics of the plasma membrane lipid bilayer structure, resulting in increased phosphatidylserine content and angiotensin II (Ang II) receptor binding.	Nitrogen Dioxide	26-42	angiotensinogen	Homo sapiens	198-212
1381395-5	1992	Macrophage cytotoxic activity induced by IFN-gamma and mAb 5D3 was inhibited by NGMMLA and coincident with high levels of NO2-released into culture fluids.	Nitrogen Dioxide	122-125	interferon gamma	Mus musculus	41-50
1283294-7	1992	Whereas in vitro exposure of the bronchus to 1.0 ppm NO2 did not significantly increase the efficacy or the potency of carbachol, exposure to 2.0 ppm NO2 increased airway smooth muscle contractions in response to carbachol, histamine, and substance P.	Nitrogen Dioxide	150-153	tachykinin precursor 1	Homo sapiens	239-250
1514642-0	1992	Structural and functional impairment of surfactant protein A after exposure to nitrogen dioxide in rats.	Nitrogen Dioxide	79-95	surfactant protein A1	Rattus norvegicus	40-60
1514642-2	1992	We now for the first time studied the in vivo exposure of the SP-A to nitrogen dioxide (NO2) and compared it to in vitro exposure effects.	Nitrogen Dioxide	70-86	surfactant protein A1	Rattus norvegicus	62-66
1514642-2	1992	We now for the first time studied the in vivo exposure of the SP-A to nitrogen dioxide (NO2) and compared it to in vitro exposure effects.	Nitrogen Dioxide	88-91	surfactant protein A1	Rattus norvegicus	62-66
1331486-4	1992	Animals exposed to NO2 24 h after silica also evidenced significant decreases in levels of lavage albumin and lactate dehydrogenase (LDH) 3 d after silica, as well as significant decreases in hydroxyproline content of the lung 30 and 60 d postsilica injection when compared to silica/air-exposed animals.	Nitrogen Dioxide	19-22	lactate dehydrogenase C	Mus musculus	110-139
1404242-1	1992	We recently reported that nitrogen dioxide (NO2), an environmental oxidant, alters the dynamics of the plasma membrane lipid bilayer structure, resulting in increased phosphatidylserine content and angiotensin II (Ang II) receptor binding.	Nitrogen Dioxide	26-42	angiotensinogen	Homo sapiens	214-220
1404242-1	1992	We recently reported that nitrogen dioxide (NO2), an environmental oxidant, alters the dynamics of the plasma membrane lipid bilayer structure, resulting in increased phosphatidylserine content and angiotensin II (Ang II) receptor binding.	Nitrogen Dioxide	44-47	angiotensinogen	Homo sapiens	198-212
1404242-1	1992	We recently reported that nitrogen dioxide (NO2), an environmental oxidant, alters the dynamics of the plasma membrane lipid bilayer structure, resulting in increased phosphatidylserine content and angiotensin II (Ang II) receptor binding.	Nitrogen Dioxide	44-47	angiotensinogen	Homo sapiens	214-220
1404242-6	1992	Exposure to Ang II resulted in translocation of PKC activity from cytosol to membrane fractions of both control and NO2-exposed cells.	Nitrogen Dioxide	116-119	angiotensinogen	Homo sapiens	12-18
1320122-1	1992	The conformationally restricted, cyclic disulfide-containing delta opioid receptor selective enkephalin analogue [D-Pen2,D-Pen5] enkephalin (DPDPE) was modified by 2" (CH3) and 3" (I, OCH3, NO2, NH2) ring substitutions and by beta-methyl conformationally constrained beta-methyltyrosine derivatives in the 1 position.	Nitrogen Dioxide	190-193	proenkephalin	Rattus norvegicus	93-103
1320122-1	1992	The conformationally restricted, cyclic disulfide-containing delta opioid receptor selective enkephalin analogue [D-Pen2,D-Pen5] enkephalin (DPDPE) was modified by 2" (CH3) and 3" (I, OCH3, NO2, NH2) ring substitutions and by beta-methyl conformationally constrained beta-methyltyrosine derivatives in the 1 position.	Nitrogen Dioxide	190-193	proenkephalin	Rattus norvegicus	129-139
15092051-4	1992	It is suggested that the most likely mechanism for this nitrate production was due to the solution of N2O5 and NO3 formed from the reaction of NO2 with O3.	Nitrogen Dioxide	143-146	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
1533682-9	1992	Among the enzymes examined, however, only the G6PDH activity increased 10% for 4.0 ppm NO2.	Nitrogen Dioxide	87-90	glucose-6-phosphate dehydrogenase	Rattus norvegicus	46-51
1736733-4	1992	During intermittent light exercise, COPD subjects demonstrated progressive decrements in FVC and FEV1 compared with baseline with 0.3 ppm NO2, but not with air.	Nitrogen Dioxide	138-141	COPD	Homo sapiens	36-40
1736733-6	1992	Subgroup analyses suggested that responsiveness to NO2 decreased with severity of COPD; in elderly normal subjects, NO2-induced reduction in FEV1 was greater among smokers than never-smokers.	Nitrogen Dioxide	51-54	COPD	Homo sapiens	82-86
1736733-6	1992	Subgroup analyses suggested that responsiveness to NO2 decreased with severity of COPD; in elderly normal subjects, NO2-induced reduction in FEV1 was greater among smokers than never-smokers.	Nitrogen Dioxide	116-119	COPD	Homo sapiens	82-86
1736733-7	1992	A comparison of COPD and elderly normal subjects also revealed distinctions in NO2-induced responsiveness.	Nitrogen Dioxide	79-82	COPD	Homo sapiens	16-20
1347312-6	1992	On the other hand, both 1B6 cells and sTNF can act synergistically with recombinant murine interferon-gamma (IFN-gamma, a known soluble macrophage-activating factor) in activating antimicrobial defense and NO2- release.	Nitrogen Dioxide	206-209	interferon gamma	Mus musculus	91-107
1347312-6	1992	On the other hand, both 1B6 cells and sTNF can act synergistically with recombinant murine interferon-gamma (IFN-gamma, a known soluble macrophage-activating factor) in activating antimicrobial defense and NO2- release.	Nitrogen Dioxide	206-209	interferon gamma	Mus musculus	109-118
1729374-9	1992	Neutralizing antibodies against mouse TNF-alpha inhibited also the release of NO2- by rIFN-gamma-activated macrophages almost completely.	Nitrogen Dioxide	78-81	tumor necrosis factor	Mus musculus	38-47
1729374-9	1992	Neutralizing antibodies against mouse TNF-alpha inhibited also the release of NO2- by rIFN-gamma-activated macrophages almost completely.	Nitrogen Dioxide	78-81	interferon gamma	Rattus norvegicus	86-96
1729374-10	1992	Macrophages incubated with rTNF-alpha in combination with a nonactivating concentration of rIFN-gamma released substantial amounts of NO2-, but rTNF-alpha and rIL-1 alpha alone, and the combination of rIL-1 alpha and a nonactivating concentration of rIFN-gamma induced only little NO2(-)-release by macrophages.	Nitrogen Dioxide	134-137	tumor necrosis factor	Rattus norvegicus	27-37
1729374-10	1992	Macrophages incubated with rTNF-alpha in combination with a nonactivating concentration of rIFN-gamma released substantial amounts of NO2-, but rTNF-alpha and rIL-1 alpha alone, and the combination of rIL-1 alpha and a nonactivating concentration of rIFN-gamma induced only little NO2(-)-release by macrophages.	Nitrogen Dioxide	134-137	interferon gamma	Rattus norvegicus	91-101
1729374-10	1992	Macrophages incubated with rTNF-alpha in combination with a nonactivating concentration of rIFN-gamma released substantial amounts of NO2-, but rTNF-alpha and rIL-1 alpha alone, and the combination of rIL-1 alpha and a nonactivating concentration of rIFN-gamma induced only little NO2(-)-release by macrophages.	Nitrogen Dioxide	134-137	interferon gamma	Rattus norvegicus	250-260
1729374-10	1992	Macrophages incubated with rTNF-alpha in combination with a nonactivating concentration of rIFN-gamma released substantial amounts of NO2-, but rTNF-alpha and rIL-1 alpha alone, and the combination of rIL-1 alpha and a nonactivating concentration of rIFN-gamma induced only little NO2(-)-release by macrophages.	Nitrogen Dioxide	281-284	tumor necrosis factor	Rattus norvegicus	27-37
1729374-10	1992	Macrophages incubated with rTNF-alpha in combination with a nonactivating concentration of rIFN-gamma released substantial amounts of NO2-, but rTNF-alpha and rIL-1 alpha alone, and the combination of rIL-1 alpha and a nonactivating concentration of rIFN-gamma induced only little NO2(-)-release by macrophages.	Nitrogen Dioxide	281-284	interferon gamma	Rattus norvegicus	91-101
1658153-5	1991	A combination of IL-1, LPS, and TNF-alpha was shown to induce maximal production of 355 +/- 51 nmol/10(6) cells/72 h of nitrite (NO2-), which was measured as a stable end-product of .N = O generation.	Nitrogen Dioxide	129-132	interleukin 1 alpha	Homo sapiens	17-21
1761573-12	1991	Second, exposure of IFN-primed macrophages to poly(I.C) in the presence of anti-IFN alpha/beta antibody was found to reduce substantially the synthesis of NO2/NO3, an alternative marker of macrophage cytocidal activation.	Nitrogen Dioxide	155-158	interferon alpha	Mus musculus	80-89
1658153-5	1991	A combination of IL-1, LPS, and TNF-alpha was shown to induce maximal production of 355 +/- 51 nmol/10(6) cells/72 h of nitrite (NO2-), which was measured as a stable end-product of .N = O generation.	Nitrogen Dioxide	129-132	tumor necrosis factor	Homo sapiens	32-41
1915557-1	1991	Previously, we reported that exposure of bone marrow-derived macrophages (M phi) to a phagocytic stimulus in the simultaneous presence of interferon-gamma (IFN-gamma) induced these cells to generate nitrite (NO2-).	Nitrogen Dioxide	208-211	interferon gamma	Rattus norvegicus	156-165
1662273-3	1991	The full potentiation by SOD of the relaxation produced by photoactivation of NO2- was matched by cytochrome c (30 microM), MnCl2 (30 microM) and CuCl2 (100 microM), all of which are scavengers of superoxide (O2-).	Nitrogen Dioxide	78-81	cytochrome c	Oryctolagus cuniculus	98-110
1919006-11	1991	In addition, increased levels of NO2- were observed in medium of A23187, TNF-alpha, or WEHI-164-stimulated PMC.	Nitrogen Dioxide	33-36	tumor necrosis factor	Rattus norvegicus	73-82
1915557-4	1991	As shown here, the capacity of phagocytosis to elicit NO2- production by IFN-gamma-treated M phi was inhibited by antibody to murine recombinant tumor necrosis factor-alpha (rTNF-alpha), suggesting that phagocytosis enabled IFN-gamma to activate M phi via the induction of TNF-alpha as an autocrine second signal.	Nitrogen Dioxide	54-57	interferon gamma	Mus musculus	73-82
1915557-4	1991	As shown here, the capacity of phagocytosis to elicit NO2- production by IFN-gamma-treated M phi was inhibited by antibody to murine recombinant tumor necrosis factor-alpha (rTNF-alpha), suggesting that phagocytosis enabled IFN-gamma to activate M phi via the induction of TNF-alpha as an autocrine second signal.	Nitrogen Dioxide	54-57	tumor necrosis factor	Mus musculus	145-172
1915557-4	1991	As shown here, the capacity of phagocytosis to elicit NO2- production by IFN-gamma-treated M phi was inhibited by antibody to murine recombinant tumor necrosis factor-alpha (rTNF-alpha), suggesting that phagocytosis enabled IFN-gamma to activate M phi via the induction of TNF-alpha as an autocrine second signal.	Nitrogen Dioxide	54-57	tumor necrosis factor	Rattus norvegicus	174-184
1915557-4	1991	As shown here, the capacity of phagocytosis to elicit NO2- production by IFN-gamma-treated M phi was inhibited by antibody to murine recombinant tumor necrosis factor-alpha (rTNF-alpha), suggesting that phagocytosis enabled IFN-gamma to activate M phi via the induction of TNF-alpha as an autocrine second signal.	Nitrogen Dioxide	54-57	interferon gamma	Mus musculus	224-233
1915557-4	1991	As shown here, the capacity of phagocytosis to elicit NO2- production by IFN-gamma-treated M phi was inhibited by antibody to murine recombinant tumor necrosis factor-alpha (rTNF-alpha), suggesting that phagocytosis enabled IFN-gamma to activate M phi via the induction of TNF-alpha as an autocrine second signal.	Nitrogen Dioxide	54-57	tumor necrosis factor	Mus musculus	175-184
1915557-5	1991	M phi NO2- production in response to rIFN-gamma and either exogenous TNF-alpha or Leishmania was strongly enhanced by prostaglandin E2, consistent with such a mechanism.	Nitrogen Dioxide	6-9	interferon gamma	Rattus norvegicus	37-47
1915557-5	1991	M phi NO2- production in response to rIFN-gamma and either exogenous TNF-alpha or Leishmania was strongly enhanced by prostaglandin E2, consistent with such a mechanism.	Nitrogen Dioxide	6-9	tumor necrosis factor	Mus musculus	69-78
1915557-6	1991	However, addition of either Leishmania promastigotes or latex beads to M phi cultures simultaneously exposed to both IFN-gamma and exogenous murine or human rTNF-alpha further potentiated activation as measured by NO2- release.	Nitrogen Dioxide	214-217	interferon gamma	Rattus norvegicus	117-126
1915557-6	1991	However, addition of either Leishmania promastigotes or latex beads to M phi cultures simultaneously exposed to both IFN-gamma and exogenous murine or human rTNF-alpha further potentiated activation as measured by NO2- release.	Nitrogen Dioxide	214-217	tumor necrosis factor	Rattus norvegicus	157-167
1915557-9	1991	Phagocytosis also increased M phi NO2- production elicited by IFN-gamma plus TNF-alpha in L-arginine-deficient media.	Nitrogen Dioxide	34-37	interferon gamma	Rattus norvegicus	62-71
1915557-9	1991	Phagocytosis also increased M phi NO2- production elicited by IFN-gamma plus TNF-alpha in L-arginine-deficient media.	Nitrogen Dioxide	34-37	tumor necrosis factor	Mus musculus	77-86
2055821-5	1991	NO2 exposure in the absence of vitamin supplementation caused a significant decrease in the elastase inhibitory capacity (EIC) of the alveolar lining fluid in the control group but not in the vitamin-supplemented group [control 3.67 +/- 0.32 micrograms alpha 1-PI/micrograms porcine pancreatic elastase (PPE) vs. vitamin-supplemented 2.75 +/- 0.17, P less than 0.03].	Nitrogen Dioxide	0-3	serpin family A member 1	Homo sapiens	253-263
1716889-2	1991	Inhibitors of poly(ADP-ribose)polymerase, namely nicotinamide, 3-aminobenzamide and 3-methoxybenzamide, prevented NO2- formation in a dose dependent manner.	Nitrogen Dioxide	114-117	poly(ADP-ribose) polymerase 1	Homo sapiens	14-40
1904084-0	1991	Macrophage NO2- production as a sensitive and rapid assay for the quantitation of murine IFN-gamma.	Nitrogen Dioxide	11-14	interferon gamma	Mus musculus	89-98
1904084-1	1991	Macrophage production of arginine-derived NO2- provides a simple method for detection and quantitation of interferon-gamma (IFN-gamma) in murine cell culture fluids.	Nitrogen Dioxide	42-45	interferon gamma	Mus musculus	106-122
1904084-1	1991	Macrophage production of arginine-derived NO2- provides a simple method for detection and quantitation of interferon-gamma (IFN-gamma) in murine cell culture fluids.	Nitrogen Dioxide	42-45	interferon gamma	Mus musculus	124-133
1904084-2	1991	When the macrophage cell line RAW 264 is cultured overnight with IFN-gamma in the presence of 10 ng/ml LPS, NO2- release, as determined by a simple colorimetric assay, is proportional to the concentration of IFN-gamma and is inhibited by monoclonal antibody to IFN-gamma.	Nitrogen Dioxide	108-111	interferon gamma	Mus musculus	65-74
1904084-2	1991	When the macrophage cell line RAW 264 is cultured overnight with IFN-gamma in the presence of 10 ng/ml LPS, NO2- release, as determined by a simple colorimetric assay, is proportional to the concentration of IFN-gamma and is inhibited by monoclonal antibody to IFN-gamma.	Nitrogen Dioxide	108-111	interferon gamma	Mus musculus	208-217
1904084-2	1991	When the macrophage cell line RAW 264 is cultured overnight with IFN-gamma in the presence of 10 ng/ml LPS, NO2- release, as determined by a simple colorimetric assay, is proportional to the concentration of IFN-gamma and is inhibited by monoclonal antibody to IFN-gamma.	Nitrogen Dioxide	108-111	interferon gamma	Mus musculus	208-217
1855487-10	1991	A slightly but significantly greater proportion of natural killer cells (CD 16) was found in the BALF obtained after NO2 exposure (7.2 +/- 3.1 vs 4.2 +/- 2.4% of total lymphocytes).	Nitrogen Dioxide	117-120	Fc gamma receptor IIIa	Homo sapiens	73-78
1855835-8	1991	Thus, the effective amount of NO2- for 6 mmol NO3- ingested was calculated to be 18 mumol, and 33% of this nitrite was trapped by ingestion of 0.45 mmol thioproline.	Nitrogen Dioxide	30-33	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
2000640-0	1991	Plasma membrane-specific phospholipase A1 activation by nitrogen dioxide in pulmonary artery endothelial cells.	Nitrogen Dioxide	56-72	lipase H	Homo sapiens	25-41
2000640-2	1991	Because perioxidative injury can activate membrane phospholipases and alter phospholipid composition of membranes, we evaluated the effects of NO2 exposure on phospholipase A1 (PLA1), phospholipase A2 (PLA2), and diacylglycerol lipase (DG lipase) activities in pulmonary artery endothelial cell plasma, mitochondrial, and microsomal membranes.	Nitrogen Dioxide	143-146	lipase H	Homo sapiens	159-175
2000640-4	1991	Exposure to 5 ppm NO2 for 48 hr resulted in a significant (p less than 0.01) increase in PLA1 activity in plasma membranes but not in mitochondrial or microsomal membranes of pulmonary artery endothelial cells, whereas PLA2 and DG lipase activities were comparable to controls in all membranes.	Nitrogen Dioxide	18-21	POU class 2 homeobox 3	Homo sapiens	89-93
2000640-4	1991	Exposure to 5 ppm NO2 for 48 hr resulted in a significant (p less than 0.01) increase in PLA1 activity in plasma membranes but not in mitochondrial or microsomal membranes of pulmonary artery endothelial cells, whereas PLA2 and DG lipase activities were comparable to controls in all membranes.	Nitrogen Dioxide	18-21	phospholipase A2 group IIA	Homo sapiens	219-223
2000640-5	1991	As a result of PLA1 activation, the total phospholipid content of the plasma membranes of NO2-exposed cells was significantly (p less than 0.01) reduced compared to controls.	Nitrogen Dioxide	90-93	POU class 2 homeobox 3	Homo sapiens	15-19
2000640-7	1991	Incorporation of exogenous PS into pulmonary artery endothelial cells mimicked the stimulatory effect of NO2 on PLA1 activity.	Nitrogen Dioxide	105-108	POU class 2 homeobox 3	Homo sapiens	112-116
2000640-8	1991	These results demonstrate that NO2 specifically reacts with the plasma membrane component of pulmonary artery endothelial cells, causing specific activation of PLA1.	Nitrogen Dioxide	31-34	POU class 2 homeobox 3	Homo sapiens	160-164
2000640-9	1991	The NO2-induced increase of PS in the plasma membranes appears to be responsible for the specific activation of PLA1 in pulmonary artery endothelial cells.	Nitrogen Dioxide	4-7	POU class 2 homeobox 3	Homo sapiens	112-116
1701382-3	1990	beta-Hexosaminidase release from 5 ppm NO2-exposed PMC stimulated with 20 microM substance P was also significantly inhibited.	Nitrogen Dioxide	39-42	O-GlcNAcase	Rattus norvegicus	0-19
1964766-3	1990	HPLC analyses indicated that meprin cleaved bradykinin and nitrobradykinin between Phe5 (or Phe5(NO2)) and Ser6.	Nitrogen Dioxide	97-100	kininogen 1	Homo sapiens	44-54
1898602-6	1991	However, TNF-alpha secretion was elevated in cultures undergoing phagocytosis and a relationship between hexosemonophosphate shunt activity and NO2- levels was evident.	Nitrogen Dioxide	144-147	tumor necrosis factor	Mus musculus	9-18
1701382-4	1990	However, the inhibition of both histamine and beta-hexosaminidase release from exposed PMC was diminished by the addition of 5 mM 2-ME during NO2 exposure.	Nitrogen Dioxide	142-145	O-GlcNAcase	Rattus norvegicus	46-65
2124251-1	1990	The present study demonstrates that murine dermal fibroblasts produce nitrite (NO2-) and nitrate (NO3-) upon treatment with interferon gamma (IFN-gamma).	Nitrogen Dioxide	79-82	interferon gamma	Mus musculus	124-151
2279740-6	1990	The level of NO2-, which is also a measurement of NO production, in the culture supernatant of TNF-alpha-activated macrophages can be progressively decreased to basal level with increasing concentrations of L-NMMA, but not with its D-enantiomer, D-NMMA.	Nitrogen Dioxide	13-16	tumor necrosis factor	Mus musculus	95-104
2124251-5	1990	Inhibition of guanosine triphosphate-cyclohydrolase I, the key enzyme of tetrahydrobiopterin de novo synthesis with 2,4-diamino-6-hydroxy-pyrimidine, leads to decreased formation of NO2- and NO3-.	Nitrogen Dioxide	182-185	NBL1, DAN family BMP antagonist	Mus musculus	191-194
2202898-1	1990	We have previously reported that the beta-glucuronidase-treated urine of mice injected intraperitoneally with pyrene during exposure to NO2 contained highly mutagenic compounds such as nitropyrene metabolites when tested by the Ames assay using Salmonella typhimurium strain TA98.	Nitrogen Dioxide	136-139	glucuronidase, beta	Mus musculus	37-55
1706189-11	1990	The functional activity of alpha 1-PI also was measured in the bronchoalveolar lavage fluids of human subjects exposed to nitrogen dioxide (0.05 ppm with 2 ppm peaks, or to 1.5 ppm continuously) for three hours and to ozone (0.4 ppm) for two hours during exercise.	Nitrogen Dioxide	122-138	serpin family A member 1	Rattus norvegicus	27-37
1700905-2	1990	Stimulation of the cells with lipopolysaccharide (LPS) resulted in a time-dependent accumulation of NO2- in the medium, reaching a plateau after 48h.	Nitrogen Dioxide	100-103	toll-like receptor 4	Mus musculus	50-53
2144548-5	1990	Citrulline and NO2-/NO3- levels in the supernatants of rat SPL MLC are decreased in the presence of NMA compared with cultures without NMA.	Nitrogen Dioxide	15-18	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	63-66
2262887-2	1990	Hydroxyurea-induced granulocytopenia attenuated the LDH and beta-GLU responses (46% and 61%, respectively) following acute, but not subacute, exposure to NO2.	Nitrogen Dioxide	154-157	glucuronidase, beta	Mus musculus	60-68
11607104-7	1990	The reductase is inactive with LB3+ is bound to nicotinate or NO2-.	Nitrogen Dioxide	62-66	chalcone reductase CHR1	Glycine max	4-13
2351828-3	1990	The culture supernatants of macrophage activated by IFN-gamma contain increased levels of NO2-, the production of which is inhibited by L-NMMA, but not by its D-enantiomer.	Nitrogen Dioxide	90-93	interferon gamma	Rattus norvegicus	52-61
2402004-0	1990	Exposure of pulmonary artery endothelial cells to nitrogen dioxide activates phospholipase A1.	Nitrogen Dioxide	50-66	lipase H	Homo sapiens	77-93
2402004-2	1990	There was a significant increase (2.25-fold) in phospholipase A1 activity in 24 and 48 hr NO2-exposed cells, whereas activities of phospholipases A2 and C and diacylglycerol lipase were comparable to control cells at both time points.	Nitrogen Dioxide	90-93	lipase H	Homo sapiens	48-64
2402004-4	1990	These results demonstrate that NO2 exposure results in specific activation of phospholipase A1.	Nitrogen Dioxide	31-34	lipase H	Homo sapiens	78-94
2093192-2	1990	Concentrations of methemoglobin in human and mouse acatalasemic hemolysates exposed to nitrogen monoxide or nitrogen dioxide were higher than those in the normal hemolysates.	Nitrogen Dioxide	108-124	hemoglobin subunit gamma 2	Homo sapiens	18-31
2096220-1	1990	Nitrogen dioxide (NO2), an environmental oxidant, is known to activate phospholipase A1 and modulate the plasma membrane structure of porcine pulmonary artery endothelial cells.	Nitrogen Dioxide	0-16	lipase H	Homo sapiens	71-87
2096220-1	1990	Nitrogen dioxide (NO2), an environmental oxidant, is known to activate phospholipase A1 and modulate the plasma membrane structure of porcine pulmonary artery endothelial cells.	Nitrogen Dioxide	18-21	lipase H	Homo sapiens	71-87
2131397-2	1990	The NO2 exposure diminishes erythrocyte count, hemoglobin concentration and produces increased nitrosyl hemoglobin (NOHb) and methemoglobin (MetHb) concentrations in peripheral blood.	Nitrogen Dioxide	4-7	hemoglobin subunit gamma 2	Homo sapiens	126-139
2131397-2	1990	The NO2 exposure diminishes erythrocyte count, hemoglobin concentration and produces increased nitrosyl hemoglobin (NOHb) and methemoglobin (MetHb) concentrations in peripheral blood.	Nitrogen Dioxide	4-7	hemoglobin subunit gamma 2	Homo sapiens	141-146
2093192-5	1990	Similar results on methemoglobin formation were obtained after exposing mice to nitrogen dioxide, although the rate of methemoglobin formation was lower in the blood of nitrogen dioxide-exposed mice.	Nitrogen Dioxide	80-96	hemoglobin subunit gamma 2	Homo sapiens	19-32
2093192-5	1990	Similar results on methemoglobin formation were obtained after exposing mice to nitrogen dioxide, although the rate of methemoglobin formation was lower in the blood of nitrogen dioxide-exposed mice.	Nitrogen Dioxide	169-185	hemoglobin subunit gamma 2	Homo sapiens	119-132
2093192-8	1990	These results indicated that the formation of methemoglobin from hemoglobin with nitrogen monoxide, nitrogen dioxide and nitrite ion appears to be controlled by the blood catalase.	Nitrogen Dioxide	100-116	hemoglobin subunit gamma 2	Homo sapiens	46-59
33809857-3	2021	Multilevel linear and logistic regression models were used to assess the associations of particulate matter (PM) and nitrogen dioxide (NO2) on log-transformed hs-CRP levels and odds ratios of CVD risk derived from CRP levels adjusted for confounders.	Nitrogen Dioxide	135-138	C-reactive protein	Homo sapiens	162-165
9693960-7	1998	Mitochondrial aldehyde reductase differed from the cytosolic enzyme by low sensitivity to known inhibitors of cytosolic aldehyde reductase, AL-1576, AL-4114 and ONO-2235.	Nitrogen Dioxide	161-164	aldo-keto reductase family 1, member B7	Rattus norvegicus	14-32
34953459-3	2022	The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds.	Nitrogen Dioxide	141-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
8584542-5	1995	When compared to air-exposed cells, NO2 induced increases in IL-6 (23.4-fold) and IL-8 (30.9-fold) mRNA abundance.	Nitrogen Dioxide	36-39	interleukin 6	Homo sapiens	61-65
8584542-5	1995	When compared to air-exposed cells, NO2 induced increases in IL-6 (23.4-fold) and IL-8 (30.9-fold) mRNA abundance.	Nitrogen Dioxide	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
8584542-6	1995	The NO2-dependent increases in mRNA expression reached a maximum between 0 and 1 h post exposure and returned to baseline levels within 24 h. IL-6 and IL-8 proteins as measured by enzyme-linked immunosorbent assays (ELISA) were also elevated in supernatants recovered from NO2-exposed BEAS-2B cells.	Nitrogen Dioxide	4-7	interleukin 6	Homo sapiens	142-146
8584542-6	1995	The NO2-dependent increases in mRNA expression reached a maximum between 0 and 1 h post exposure and returned to baseline levels within 24 h. IL-6 and IL-8 proteins as measured by enzyme-linked immunosorbent assays (ELISA) were also elevated in supernatants recovered from NO2-exposed BEAS-2B cells.	Nitrogen Dioxide	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
34844798-0	2022	A room temperature all-optical sensor based on two-dimensional SnS2 for highly sensitive and reversible NO2 sensing.	Nitrogen Dioxide	104-107	sodium voltage-gated channel alpha subunit 11	Homo sapiens	63-67
34844798-3	2022	In this work, we demonstrate the development of a room temperature, all-optical, and high-performance NO2 sensor based on a simple D-shaped optical fiber incorporated with ultra-thin two-dimensional (2D) tin disulfide (SnS2).	Nitrogen Dioxide	102-105	sodium voltage-gated channel alpha subunit 11	Homo sapiens	219-223
34844798-5	2022	Upon exposure to NO2 at room temperature, the physisorbed gas molecules induce charge exchange with the 2D SnS2.	Nitrogen Dioxide	17-20	sodium voltage-gated channel alpha subunit 11	Homo sapiens	107-111
34583160-7	2022	Mel pre-treatment enhanced enzyme activities and expression of proteins related to the ascorbic acid-glutathione cycle and thioredoxin-peroxiredoxin pathway in leaves exposed to NO2, thus regulating their redox balance.	Nitrogen Dioxide	178-181	thioredoxin H-type 2	Nicotiana tabacum	123-134
34529971-3	2022	It is an effective method to obtain NO2- by denitrifying the NO3-, including the by-product of Anammox.	Nitrogen Dioxide	36-40	NBL1, DAN family BMP antagonist	Homo sapiens	61-64
34529971-6	2022	The reduction of NO3- amount increased with an increase in Inf-NO3-, which was greater than that of NO2-.	Nitrogen Dioxide	100-103	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
34529971-9	2022	This study showed that NO2- can be supplied by reducing the by-product NO3- with denitrification cathode at Anammox environment in-situ.	Nitrogen Dioxide	23-27	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
34687681-10	2022	The data also indicated that as much as 80% of the removed NO3- was converted to NO2-, and this is noteworthy.	Nitrogen Dioxide	81-85	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
34914357-6	2022	In addition, in situ differential electrochemical mass spectrometry (DEMS) indicated that ultrafast *NO2- to *NO reduction and highly selective *NO to *N2O or *N transformation played crucial roles during the NO3- reduction process.	Nitrogen Dioxide	101-104	NBL1, DAN family BMP antagonist	Homo sapiens	209-212
34418836-2	2022	The present article addresses a detailed investigation on the potential of the monolayer PC3 compound as a possible sensor material for environmentally toxic nitrogen-containing gases (NCGs), namely NH3, NO, and NO2.	Nitrogen Dioxide	212-215	chromobox 8	Homo sapiens	89-92
34418836-10	2022	Although physisorption is observed for all the NCGs on the PC3 surface, NO2 is found to convert into NO and O at 5.05 ps (at 300 K) under molecular dynamics simulation.	Nitrogen Dioxide	72-75	chromobox 8	Homo sapiens	59-62
34418836-12	2022	Along with the considerable adsorption energies for NO and NO2 gas molecules, their shorter recovery time (0.071 s and 0.037 s, respectively) from the PC3 surface also identifies 2D PC3 as a promising sensor material for those environmentally toxic gases.	Nitrogen Dioxide	59-62	chromobox 8	Homo sapiens	151-154
34418836-12	2022	Along with the considerable adsorption energies for NO and NO2 gas molecules, their shorter recovery time (0.071 s and 0.037 s, respectively) from the PC3 surface also identifies 2D PC3 as a promising sensor material for those environmentally toxic gases.	Nitrogen Dioxide	59-62	chromobox 8	Homo sapiens	182-185
34418836-14	2022	The transport properties (I-V characteristics) reflect the significant sensitivity of PC3 monolayer toward NO and NO2 molecules.	Nitrogen Dioxide	114-117	chromobox 8	Homo sapiens	86-89
34487928-5	2022	When tested in 0.1 M phosphate buffer saline with 200 ppm NO2-, such Ni2P/NF is able to obtain a large NH3 yield rate of 2692.2 +- 92.1 mug h-1 cm-2 (3282.9 +- 112.3 mug h-1 mgcat.-1), a high Faradic efficiency of 90.2 +- 3.0%, and selectivity of 87.0 +- 1.7% at -0.3 V versus a reversible hydrogen electrode.	Nitrogen Dioxide	58-62	neurofascin	Homo sapiens	74-76
34396968-0	2022	Synergically engineering defect and interlayer in SnS2 for enhanced room-temperature NO2 sensing.	Nitrogen Dioxide	85-88	sodium voltage-gated channel alpha subunit 11	Homo sapiens	50-54
34396968-2	2022	Herein, ethylene glycol intercalated Al-doped SnS2 (EG-Al-SnS2) featuring Al doping, sulfur (S) vacancies, and an expanded interlayer spacing was prepared and developed as an active NO2 sensing material.	Nitrogen Dioxide	182-185	sodium voltage-gated channel alpha subunit 11	Homo sapiens	46-50
34634403-8	2022	For a 10 mug/m3 increase in short-term exposure to O3, NO2, and SO2, there were significant increases of 1.05% (95%CI: 0.09%, 2.02%), 1.60% (95%CI: 0.49%, 2.72%), and 10.44% (95%CI: 4.20%, 17.05%) in CRP, respectively.	Nitrogen Dioxide	55-58	C-reactive protein	Homo sapiens	200-203
34396968-2	2022	Herein, ethylene glycol intercalated Al-doped SnS2 (EG-Al-SnS2) featuring Al doping, sulfur (S) vacancies, and an expanded interlayer spacing was prepared and developed as an active NO2 sensing material.	Nitrogen Dioxide	182-185	sodium voltage-gated channel alpha subunit 11	Homo sapiens	52-62
34396968-3	2022	Compared to the pristine SnS2 with failure in detecting NO2 at room temperature, the developed EG-Al-SnS2 exhibited a better conductivity, which was beneficial for realizing the room-temperature NO2 sensing.	Nitrogen Dioxide	56-59	sodium voltage-gated channel alpha subunit 11	Homo sapiens	25-29
34396968-3	2022	Compared to the pristine SnS2 with failure in detecting NO2 at room temperature, the developed EG-Al-SnS2 exhibited a better conductivity, which was beneficial for realizing the room-temperature NO2 sensing.	Nitrogen Dioxide	56-59	sodium voltage-gated channel alpha subunit 11	Homo sapiens	101-105
34396968-3	2022	Compared to the pristine SnS2 with failure in detecting NO2 at room temperature, the developed EG-Al-SnS2 exhibited a better conductivity, which was beneficial for realizing the room-temperature NO2 sensing.	Nitrogen Dioxide	195-198	sodium voltage-gated channel alpha subunit 11	Homo sapiens	25-29
34396968-3	2022	Compared to the pristine SnS2 with failure in detecting NO2 at room temperature, the developed EG-Al-SnS2 exhibited a better conductivity, which was beneficial for realizing the room-temperature NO2 sensing.	Nitrogen Dioxide	195-198	sodium voltage-gated channel alpha subunit 11	Homo sapiens	101-105
34396968-4	2022	As a result, a high sensing response of 410% toward 2 ppm NO2 was achieved at room temperature by using the 3% EG-Al-SnS2 as the sensing material.	Nitrogen Dioxide	58-61	sodium voltage-gated channel alpha subunit 11	Homo sapiens	117-121
34396968-5	2022	Such outstanding sensing performance was attributed to the enhanced electronic interaction of NO2 on the surface of SnS2 induced by the synergistic effect of Al doping, S vacancies, and the expanded interlayer spacing, which is directly revealed by the in-suit measurement based on near-ambient pressure X-ray photoelectronic spectroscopy (NAP-XPS).	Nitrogen Dioxide	94-97	sodium voltage-gated channel alpha subunit 11	Homo sapiens	116-120
34634403-9	2022	Meanwhile, a 10 mug/m3 increase in NO2 was also associated with a 4.85% (95%CI: 1.10%, 8.73%) increase in TNF-alpha.	Nitrogen Dioxide	35-38	tumor necrosis factor	Homo sapiens	106-115
34537521-10	2021	RESULTS: A consistent pattern of results indicated that greater exposure to NO2 and PM2.5 absorbance was associated with higher levels of brain Abeta deposition, while greater exposure to PM10 and PM2.5was associated with higher levels of CSF NfL.	Nitrogen Dioxide	76-79	amyloid beta precursor protein	Homo sapiens	144-149
34874391-4	2021	Furthermore, analysis via a combination of experimental and theoretical methods revealed that the -OH group-functionalized samples reduce the energy barriers for conversion of the main intermediate (NO2), which is easily transformed to NO2-, thus accelerating the oxidation of NO to the final product (NO3-).	Nitrogen Dioxide	199-202	NBL1, DAN family BMP antagonist	Homo sapiens	302-305
34874391-4	2021	Furthermore, analysis via a combination of experimental and theoretical methods revealed that the -OH group-functionalized samples reduce the energy barriers for conversion of the main intermediate (NO2), which is easily transformed to NO2-, thus accelerating the oxidation of NO to the final product (NO3-).	Nitrogen Dioxide	236-239	NBL1, DAN family BMP antagonist	Homo sapiens	302-305
34947725-6	2021	Gas sensor selectivity was tested with five different gases (CO, SO2, NO2, NH3 and H2S) and the sensor showed great selectivity towards H2S gas.	Nitrogen Dioxide	70-73	gastrin	Homo sapiens	0-3
34947725-6	2021	Gas sensor selectivity was tested with five different gases (CO, SO2, NO2, NH3 and H2S) and the sensor showed great selectivity towards H2S gas.	Nitrogen Dioxide	70-73	gastrin	Homo sapiens	140-143
34793131-9	2021	Computational modeling efforts were used to show distinct differences on acid gas (NO2 and SO2) binding energies for RE-DOBDC MOFs when comparing the monodentate/bidentate combined linker with the bidentate-only linker crystal structures.	Nitrogen Dioxide	83-86	gastrin	Homo sapiens	78-81
34879788-4	2021	Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha.	Nitrogen Dioxide	99-102	C-C motif chemokine ligand 2	Homo sapiens	209-213
34879788-4	2021	Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha.	Nitrogen Dioxide	99-102	interleukin 6	Homo sapiens	215-219
34879788-4	2021	Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha.	Nitrogen Dioxide	99-102	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
34879788-4	2021	Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha.	Nitrogen Dioxide	99-102	interleukin 10	Homo sapiens	227-232
34879788-4	2021	Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha.	Nitrogen Dioxide	99-102	interleukin 17A	Homo sapiens	234-239
34879788-4	2021	Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha.	Nitrogen Dioxide	99-102	interferon alpha 1	Homo sapiens	241-250
34879788-4	2021	Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha.	Nitrogen Dioxide	99-102	tumor necrosis factor	Homo sapiens	256-265
34734688-0	2021	Increased Active Sites and Charge Transfer in the SnS2/TiO2 Heterostructure for Visible-Light-Assisted NO2 Sensing.	Nitrogen Dioxide	103-106	sodium voltage-gated channel alpha subunit 11	Homo sapiens	50-54
34734688-3	2021	Herein, to promote the study of SnS2-based gas sensors, a hierarchical SnS2/TiO2 heterostructure was synthesized and used as a sensing material to detect NO2 with the help of light illumination.	Nitrogen Dioxide	154-157	sodium voltage-gated channel alpha subunit 11	Homo sapiens	32-36
34734688-3	2021	Herein, to promote the study of SnS2-based gas sensors, a hierarchical SnS2/TiO2 heterostructure was synthesized and used as a sensing material to detect NO2 with the help of light illumination.	Nitrogen Dioxide	154-157	sodium voltage-gated channel alpha subunit 11	Homo sapiens	71-75
34734688-4	2021	Through the synergistic effect of the SnS2/TiO2 heterostructure and 525 nm light activation, the NO2 sensor based on the SnS2/TiO2 heterostructure exhibited a high response factor of 526% toward 1 ppm NO2 and a short response/recovery time of 43/102 s at room temperature due to the enhanced charge transfer and increased adsorption sites, which was superior to the vast majority of other NO2 sensors.	Nitrogen Dioxide	97-100	sodium voltage-gated channel alpha subunit 11	Homo sapiens	38-42
34340182-4	2021	METHODS: In this study, land use regression models (LUR) were developed to predict the outdoor nitrogen dioxide (NO2) concentration in the study area of the Western Region Birth Cohort in Sao Paulo.	Nitrogen Dioxide	113-116	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	188-191
34734688-4	2021	Through the synergistic effect of the SnS2/TiO2 heterostructure and 525 nm light activation, the NO2 sensor based on the SnS2/TiO2 heterostructure exhibited a high response factor of 526% toward 1 ppm NO2 and a short response/recovery time of 43/102 s at room temperature due to the enhanced charge transfer and increased adsorption sites, which was superior to the vast majority of other NO2 sensors.	Nitrogen Dioxide	97-100	sodium voltage-gated channel alpha subunit 11	Homo sapiens	121-125
34734688-4	2021	Through the synergistic effect of the SnS2/TiO2 heterostructure and 525 nm light activation, the NO2 sensor based on the SnS2/TiO2 heterostructure exhibited a high response factor of 526% toward 1 ppm NO2 and a short response/recovery time of 43/102 s at room temperature due to the enhanced charge transfer and increased adsorption sites, which was superior to the vast majority of other NO2 sensors.	Nitrogen Dioxide	201-204	sodium voltage-gated channel alpha subunit 11	Homo sapiens	38-42
34734688-4	2021	Through the synergistic effect of the SnS2/TiO2 heterostructure and 525 nm light activation, the NO2 sensor based on the SnS2/TiO2 heterostructure exhibited a high response factor of 526% toward 1 ppm NO2 and a short response/recovery time of 43/102 s at room temperature due to the enhanced charge transfer and increased adsorption sites, which was superior to the vast majority of other NO2 sensors.	Nitrogen Dioxide	201-204	sodium voltage-gated channel alpha subunit 11	Homo sapiens	121-125
34734688-4	2021	Through the synergistic effect of the SnS2/TiO2 heterostructure and 525 nm light activation, the NO2 sensor based on the SnS2/TiO2 heterostructure exhibited a high response factor of 526% toward 1 ppm NO2 and a short response/recovery time of 43/102 s at room temperature due to the enhanced charge transfer and increased adsorption sites, which was superior to the vast majority of other NO2 sensors.	Nitrogen Dioxide	389-392	sodium voltage-gated channel alpha subunit 11	Homo sapiens	121-125
34734688-5	2021	An obvious decrease in the surface-adsorbed oxygen content based on the X-ray photoelectron spectroscopy measurement further confirmed that light illumination was helpful to clear the surface of SnS2/TiO2 and thus increased active sites for NO2 sensing.	Nitrogen Dioxide	241-244	sodium voltage-gated channel alpha subunit 11	Homo sapiens	195-199
34571246-4	2021	In this study, the risk of inhalation of toxic gases such as CO, HCN and NO2 during RPUF fires was demonstrated convincingly through the analysis of carboxyhemoglobin (COHb), cyanide (CN-) and methemoglobin (MetHb) in the postmortem blood samples of 38 victims of RPUF fires.	Nitrogen Dioxide	73-76	hemoglobin subunit gamma 2	Homo sapiens	193-206
34328950-3	2021	We found that (1) changes in NO3 precursors (NO2 and O3) led to a significant increase in NO3 formation in the surface layer in winter but a decrease in summer; (2) a reduction in NOx promoted thermal equilibrium, favoring the formation of NO3 rather than dinitrogen pentoxide (N2O5).	Nitrogen Dioxide	45-48	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
34328950-3	2021	We found that (1) changes in NO3 precursors (NO2 and O3) led to a significant increase in NO3 formation in the surface layer in winter but a decrease in summer; (2) a reduction in NOx promoted thermal equilibrium, favoring the formation of NO3 rather than dinitrogen pentoxide (N2O5).	Nitrogen Dioxide	45-48	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
34328950-3	2021	We found that (1) changes in NO3 precursors (NO2 and O3) led to a significant increase in NO3 formation in the surface layer in winter but a decrease in summer; (2) a reduction in NOx promoted thermal equilibrium, favoring the formation of NO3 rather than dinitrogen pentoxide (N2O5).	Nitrogen Dioxide	45-48	NBL1, DAN family BMP antagonist	Homo sapiens	240-243
34571246-4	2021	In this study, the risk of inhalation of toxic gases such as CO, HCN and NO2 during RPUF fires was demonstrated convincingly through the analysis of carboxyhemoglobin (COHb), cyanide (CN-) and methemoglobin (MetHb) in the postmortem blood samples of 38 victims of RPUF fires.	Nitrogen Dioxide	73-76	hemoglobin subunit gamma 2	Homo sapiens	208-213
34571246-6	2021	Mean concentrations of COHb and cyanide in group 1 without injuries were approximately two times higher than in group 2 with severe injuries, while concentrations of free MetHb showing possibility of NO2 inhalation were approximately six times lower than in group 2.	Nitrogen Dioxide	200-203	hemoglobin subunit gamma 2	Homo sapiens	171-176
34576143-5	2021	The effects of NO2-OA on mESC correlated with reduced phosphorylation of STAT3.	Nitrogen Dioxide	15-18	signal transducer and activator of transcription 3	Mus musculus	73-78
34506950-4	2021	Both animal and human experiments indicated that inorganic NO3- modulates the oral microbiome by increasing the abundance of health-associated NO3--reducing bacteria (e.g., Neisseria and Rothia) and decreasing the plenty of species Prevotella and Veillonella, leading to oral NO2- accumulation and improved systemic  NO availability.	Nitrogen Dioxide	276-280	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
34733277-8	2021	Results: Acute exposure to PM10 and NO2 was negatively associated to RV16-induced IFNbeta mRNA.	Nitrogen Dioxide	36-39	IFN1@	Homo sapiens	82-89
34733277-12	2021	Conclusions: Short-term exposure to high levels of NO2 and PM10 is associated to a reduced IFN-beta expression by the airway epithelium, which may lead to increased viral replication.	Nitrogen Dioxide	51-54	IFN1@	Homo sapiens	91-99
34147866-11	2021	There were significant association of P. bandonii with upregulation of CD63 expressed on neutrophil and exposure to NO2.	Nitrogen Dioxide	116-119	CD63 molecule	Homo sapiens	71-75
34300377-3	2021	The performance of a compact diffusion-based Personal Exposure Kit (PEK) was assessed for real-time gaseous pollutant measurement (CO, O3, and NO2) under typical environmental conditions encountered in the subtropical city of Hong Kong.	Nitrogen Dioxide	143-146	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	63-66
34934887-9	2021	Women in the highest quartile of NO2 exposure, a traffic-related pollutant, had higher estimated AMH concentrations (Q4 vs. Q1, 42.9%; 95% CI = -3.4, 111.4) compared with the lowest quartile.	Nitrogen Dioxide	33-36	anti-Mullerian hormone	Homo sapiens	97-100
34492793-7	2021	We also found that prolactin (Prl), through its anti-inflammatory activity and remyelination, might play a major role in the sex-specific neurobehavioral disorder in male mice caused by NO2 exposure.	Nitrogen Dioxide	186-189	prolactin	Mus musculus	19-28
34492793-7	2021	We also found that prolactin (Prl), through its anti-inflammatory activity and remyelination, might play a major role in the sex-specific neurobehavioral disorder in male mice caused by NO2 exposure.	Nitrogen Dioxide	186-189	prolactin	Mus musculus	30-33
34445374-4	2021	Dabigatran"s effects on endothelial function in Ang II-treated mice were evidenced by improved NO-dependent relaxation in the aorta in response to acetylcholine in vivo (MRI measurements) and increased systemic NO bioavailability (NO2- quantification) with a concomitant increased ex vivo production of endothelium-derived NO (EPR analysis).	Nitrogen Dioxide	231-234	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	48-54
34324651-10	2021	Critically, the therapeutic efficacy of NO2-OA in MFS was further emphasized by demonstrating its capability to reduce lethal aortic complications in Fbn1C1041G/+mice challenged with Angiotensin II.	Nitrogen Dioxide	40-43	fibrillin 1	Mus musculus	150-154
34329035-2	2021	Here we developed the chrysanthemum flower-like silica (KCC-1) loaded with highly dispersed copper nanoparticles for efficient NO2 removal under ambient conditions.	Nitrogen Dioxide	127-130	solute carrier family 12 member 4	Homo sapiens	56-61
34329035-3	2021	We carefully studied the NO2 removal performance of Cu-KCC-1 materials with different copper loadings (0, 5, 10, and 15 wt%) and demonstrated the Cu0 nanoparticles (10 wt%) boosted the NO2 removal capacity of KCC-1 by up to 51 times.	Nitrogen Dioxide	25-28	solute carrier family 12 member 4	Homo sapiens	55-60
34329035-3	2021	We carefully studied the NO2 removal performance of Cu-KCC-1 materials with different copper loadings (0, 5, 10, and 15 wt%) and demonstrated the Cu0 nanoparticles (10 wt%) boosted the NO2 removal capacity of KCC-1 by up to 51 times.	Nitrogen Dioxide	25-28	solute carrier family 12 member 4	Homo sapiens	209-214
34329035-3	2021	We carefully studied the NO2 removal performance of Cu-KCC-1 materials with different copper loadings (0, 5, 10, and 15 wt%) and demonstrated the Cu0 nanoparticles (10 wt%) boosted the NO2 removal capacity of KCC-1 by up to 51 times.	Nitrogen Dioxide	185-188	solute carrier family 12 member 4	Homo sapiens	55-60
34329035-3	2021	We carefully studied the NO2 removal performance of Cu-KCC-1 materials with different copper loadings (0, 5, 10, and 15 wt%) and demonstrated the Cu0 nanoparticles (10 wt%) boosted the NO2 removal capacity of KCC-1 by up to 51 times.	Nitrogen Dioxide	185-188	solute carrier family 12 member 4	Homo sapiens	209-214
34329035-4	2021	KCC-1 loaded with 10 wt% of copper was verified to be the best-performing adsorbents, featuring an efficient NO2 removal capacity of 3.63 mmol/g and a moderate NO release (11.3%), which was primarily attributed to the presence of Cu0 nanoparticles.	Nitrogen Dioxide	109-112	solute carrier family 12 member 4	Homo sapiens	0-5
34515997-3	2022	It was found that NO3 - ion is easily reduced into NO2 - and NOx and then further into N2 and NH3 (in the form of NH4 + ) in the process.	Nitrogen Dioxide	51-54	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
34514258-6	2021	The change in the epsilon-CL-20 decomposition mechanism should be attributed to the catalytic action of CNT, decreasing the formation of NO2.	Nitrogen Dioxide	137-140	epithelial membrane protein 1	Homo sapiens	26-31
34445757-8	2021	In vitro studies of TGFbeta-stimulated primary cardiac fibroblasts further revealed that the anti-fibrotic effects of NO2-OA rely on its capability to attenuate fibroblast to myofibroblast transdifferentiation by inhibiting phosphorylation of TGFbeta downstream targets.	Nitrogen Dioxide	118-121	transforming growth factor alpha	Mus musculus	20-27
34445757-8	2021	In vitro studies of TGFbeta-stimulated primary cardiac fibroblasts further revealed that the anti-fibrotic effects of NO2-OA rely on its capability to attenuate fibroblast to myofibroblast transdifferentiation by inhibiting phosphorylation of TGFbeta downstream targets.	Nitrogen Dioxide	118-121	transforming growth factor alpha	Mus musculus	243-250
34445757-9	2021	In conclusion, we demonstrate a substantial therapeutic benefit of NO2-OA in a murine model of DCM, mediated by interfering with endogenously activated TGFbeta signaling.	Nitrogen Dioxide	67-70	transforming growth factor alpha	Mus musculus	152-159
34411816-7	2021	The positive association only appeared for NO2: positive associations between SAB and NO2 were observed in both single-day models (lag 0, lag 1, lag 3, and lag 4) and cumulative exposure models (lag 01, lag 03, and lag 05) and the most significant effects were observed at lag 05 (3.289%; 95% CI: 1.568%, 5.011%).	Nitrogen Dioxide	43-46	ceramide synthase 1	Homo sapiens	138-143
34411816-7	2021	The positive association only appeared for NO2: positive associations between SAB and NO2 were observed in both single-day models (lag 0, lag 1, lag 3, and lag 4) and cumulative exposure models (lag 01, lag 03, and lag 05) and the most significant effects were observed at lag 05 (3.289%; 95% CI: 1.568%, 5.011%).	Nitrogen Dioxide	43-46	lymphocyte activating 3	Homo sapiens	145-150
34411816-7	2021	The positive association only appeared for NO2: positive associations between SAB and NO2 were observed in both single-day models (lag 0, lag 1, lag 3, and lag 4) and cumulative exposure models (lag 01, lag 03, and lag 05) and the most significant effects were observed at lag 05 (3.289%; 95% CI: 1.568%, 5.011%).	Nitrogen Dioxide	86-89	ceramide synthase 1	Homo sapiens	138-143
34411816-7	2021	The positive association only appeared for NO2: positive associations between SAB and NO2 were observed in both single-day models (lag 0, lag 1, lag 3, and lag 4) and cumulative exposure models (lag 01, lag 03, and lag 05) and the most significant effects were observed at lag 05 (3.289%; 95% CI: 1.568%, 5.011%).	Nitrogen Dioxide	86-89	lymphocyte activating 3	Homo sapiens	145-150
34292749-3	2021	The representative compound 4a was able to slowly generate low concentrations of NO2- by reaction with a thiol-containing nucleophile, and the NO2- was selectively converted into NO under ischemic/hypoxia conditions to protect primary rat neurons from oxygen-glucose deprivation and recovery (OGD/R)-induced cytotoxicity by enhancing the Nrf2 signaling and activating the NO/cGMP/PKG pathway.	Nitrogen Dioxide	81-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	338-342
34292749-3	2021	The representative compound 4a was able to slowly generate low concentrations of NO2- by reaction with a thiol-containing nucleophile, and the NO2- was selectively converted into NO under ischemic/hypoxia conditions to protect primary rat neurons from oxygen-glucose deprivation and recovery (OGD/R)-induced cytotoxicity by enhancing the Nrf2 signaling and activating the NO/cGMP/PKG pathway.	Nitrogen Dioxide	143-146	NFE2 like bZIP transcription factor 2	Rattus norvegicus	338-342
34351097-0	2021	Glutathione (GSH) and superoxide dismutase (SOD) levels among junior high school students induced by indoor particulate matter 2.5 (PM2.5) and nitrogen dioxide (NO2) exposure.	Nitrogen Dioxide	161-164	superoxide dismutase 1	Homo sapiens	22-42
34351097-0	2021	Glutathione (GSH) and superoxide dismutase (SOD) levels among junior high school students induced by indoor particulate matter 2.5 (PM2.5) and nitrogen dioxide (NO2) exposure.	Nitrogen Dioxide	161-164	superoxide dismutase 1	Homo sapiens	44-47
34206755-0	2021	Exposure to Ambient NO2 Increases the Risk of Dry Eye Syndrome in Females: An 11-Year Population-Based Study.	Nitrogen Dioxide	20-23	DDB1 and CUL4 associated factor 7	Homo sapiens	75-80
34143594-0	2021	Proliferation of the Light and Gas Interaction with GaN Nanorods Grown on a V-Grooved Si(111) Substrate for UV Photodetector and NO2 Gas Sensor Applications.	Nitrogen Dioxide	129-132	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	31-34
34143594-0	2021	Proliferation of the Light and Gas Interaction with GaN Nanorods Grown on a V-Grooved Si(111) Substrate for UV Photodetector and NO2 Gas Sensor Applications.	Nitrogen Dioxide	129-132	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	133-136
34143594-6	2021	The photo-assisted sensing makes it possible to detect NO2 gas at the ppb level at room temperature, resulting in significant power reduction.	Nitrogen Dioxide	55-58	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	59-62
34086442-4	2021	The uptake process of NO2 on OA gives HONO as a reaction product, and the highest HONO production was observed upon the heterogeneous reaction of NO2 with OA in the presence of nitrate (NO3-) ions.	Nitrogen Dioxide	22-25	NBL1, DAN family BMP antagonist	Homo sapiens	186-189
34203021-7	2021	NO2 had statistically significant effects at lag2, lag3, and lag4.	Nitrogen Dioxide	0-3	granulysin	Homo sapiens	45-49
34203021-7	2021	NO2 had statistically significant effects at lag2, lag3, and lag4.	Nitrogen Dioxide	0-3	lymphocyte activating 3	Homo sapiens	51-55
34086019-4	2021	By virtue of a novel combination of catalyst design, reaction kinetics, isotope labeling, and multiple spectroscopic techniques, the real catalytic site for the conversion of -NO2 to -NH2 is identified to be the water-hydroxyl transition metal complex, which could further react with NaBH4 to form a new triangular configuration metal complex of H3B-water-hydroxyl with dynamic features.	Nitrogen Dioxide	176-179	H3 clustered histone 4	Homo sapiens	346-349
34248678-3	2021	Effects of these agonists were compared with effects of nitro-oleic acid (OA-NO2), an electrophilic nitro-fatty acid, known to activate TRPV1, TRPA1 or TRPC channels in sensory neurons.	Nitrogen Dioxide	77-80	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	136-141
34467355-2	2021	The generation of NO3  , however, is of grand demand due to the need of NO2  /O3, radioactive element, or NaNO3/HNO3 in the presence of highly energized electron/light.	Nitrogen Dioxide	72-75	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
34085520-3	2021	At this site, MPO mediates endothelial dysfunction by catalytically consuming nitric oxide (NO) and producing reactive oxidants, hypochlorous acid (HOCl) and the nitrogen dioxide radical ( NO2).	Nitrogen Dioxide	189-192	myeloperoxidase	Homo sapiens	14-17
34085520-8	2021	Nitroxides also differentially inhibited protein nitration catalyzed by both purified and endothelial-localized MPO, which was dependent on  NO2 scavenging rather than MPO inhibition.	Nitrogen Dioxide	141-144	myeloperoxidase	Homo sapiens	112-115
34086442-4	2021	The uptake process of NO2 on OA gives HONO as a reaction product, and the highest HONO production was observed upon the heterogeneous reaction of NO2 with OA in the presence of nitrate (NO3-) ions.	Nitrogen Dioxide	146-149	NBL1, DAN family BMP antagonist	Homo sapiens	186-189
34086442-5	2021	The formation of gaseous nitroaromatic compounds was also enhanced in the presence of NO3- ions upon light-induced heterogeneous processing of NO2 with OA, as revealed by membrane inlet single-photon ionization time-of-flight mass spectrometry (MI-SPI-TOFMS).	Nitrogen Dioxide	143-146	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
35398417-4	2022	Here, we evaluated the associations between PM10, NO2 and O3 exposure (on the day of the blood sample collection and on the day before, and the mean annual residential level) and levels of the inflammatory biomarkers high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-17A, IL-22, and tumor necrosis factor alpha.	Nitrogen Dioxide	50-53	C-reactive protein	Homo sapiens	234-252
34075750-2	2021	Herein, we report a gas-driven conductive MOF (A) constructed from calix(4)resorcinarene macrocycle and Co(II) cations, which shows the conductivity enhancement by about eight orders of magnitude through NO2 adsorption.	Nitrogen Dioxide	204-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
34075750-5	2021	When NO2 is evacuated, MOF A quickly changes from a conductor back to an insulator in 42 s. In the crystal structure of NO2-adsorbed MOF (termed as A-NO2), NO2 molecule connects Co(II) and uncoordinated carboxylate groups through hydrogen-bonding interactions to form a conductive pathway, greatly reducing the electron transmission distance between each two metal clusters.	Nitrogen Dioxide	5-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
34075750-5	2021	When NO2 is evacuated, MOF A quickly changes from a conductor back to an insulator in 42 s. In the crystal structure of NO2-adsorbed MOF (termed as A-NO2), NO2 molecule connects Co(II) and uncoordinated carboxylate groups through hydrogen-bonding interactions to form a conductive pathway, greatly reducing the electron transmission distance between each two metal clusters.	Nitrogen Dioxide	120-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
34075750-5	2021	When NO2 is evacuated, MOF A quickly changes from a conductor back to an insulator in 42 s. In the crystal structure of NO2-adsorbed MOF (termed as A-NO2), NO2 molecule connects Co(II) and uncoordinated carboxylate groups through hydrogen-bonding interactions to form a conductive pathway, greatly reducing the electron transmission distance between each two metal clusters.	Nitrogen Dioxide	156-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
35428539-0	2022	Boosting room-temperature NO2 detection via in-situ interfacial engineering on Ag2S/SnS2 heterostructures.	Nitrogen Dioxide	26-29	angiotensin II receptor type 1	Homo sapiens	79-83
35428539-5	2022	Benefiting from the high-quality interface of the heterostructures, the resultant Ag2S/SnS2 sensor delivered an ultrahigh response (286%) together with short response/recovery time (17 s/38 s) to 1 ppm NO2.	Nitrogen Dioxide	202-205	angiotensin II receptor type 1	Homo sapiens	82-86
35597020-3	2022	In 0.1 M NaOH with 0.1 M NO2-, such catalyst exhibits a maximum ammonia yield of 5,751 mug h-1 cm-2 (57,510 mug h-1 mgAg-1) and high Faradaic efficiency up to 97.7 %.	Nitrogen Dioxide	25-29	H1.5 linker histone, cluster member	Homo sapiens	91-99
35472539-2	2022	Herein, for the first time, a robust dual-response fluorescent sensor CGT with two different emission fluorophores and dual well-known response-group for visual bisulphites (HSO3-) and nitrites (NO2-) detection was reported.	Nitrogen Dioxide	195-199	UDP glycosyltransferase 8	Homo sapiens	70-73
35472539-3	2022	Specifically, once CGT was incubated with HSO3- firstly, the color of the test solution changed to dark yellow with no-fluorescence emission, following added NO2-, the color of the test solution changed to yellow with a bright cyan emission.	Nitrogen Dioxide	158-162	UDP glycosyltransferase 8	Homo sapiens	19-22
35239329-4	2022	Nevertheless, 30 biomarkers were in association with at least one environmental factor; e.g., C-reactive protein levels were positively associated with NO (padj = 2.99 x 10-4), NO2 (padj = 4.15 x 10-4), and PM2.5 (padj = 1.92 x 10-6) even after multiple testing adjustment.	Nitrogen Dioxide	177-180	C-reactive protein	Homo sapiens	94-112
35576800-11	2022	Mediation analysis showed that only miR-26a-5p significantly mediated air pollutant (PM2.5 and NO2)-induced effects on blood CRP and total cholesterol levels.	Nitrogen Dioxide	95-98	C-reactive protein	Homo sapiens	125-128
35576800-13	2022	Similarly, the proportions of indirect effects of miR-26a-5p on the association between NO2 exposure and CRP were 46.8% at lag2 (0.06 (0.02, 0.11), P = 0.003), 61.2% at lag3 (0.05 (0.00, 0.09), P = 0.04), and 30.8% at 5-day moving average (0.06 (0.02, 0.10), P = 0.01).	Nitrogen Dioxide	88-91	C-reactive protein	Homo sapiens	105-108
35576800-13	2022	Similarly, the proportions of indirect effects of miR-26a-5p on the association between NO2 exposure and CRP were 46.8% at lag2 (0.06 (0.02, 0.11), P = 0.003), 61.2% at lag3 (0.05 (0.00, 0.09), P = 0.04), and 30.8% at 5-day moving average (0.06 (0.02, 0.10), P = 0.01).	Nitrogen Dioxide	88-91	granulysin	Homo sapiens	123-127
35292243-9	2022	The mediation study suggested that HGF could explain 19% of the short-term effect of NO2 on blood pressure, but other study designs are needed to prove the causal directionality between HGF and blood pressure.	Nitrogen Dioxide	85-88	hepatocyte growth factor	Homo sapiens	35-38
35013806-1	2022	Gas-phase ozone (O3) and nitrogen dioxide (NO2) can react with environmentally exposed proteins to induce chemical modifications such as the formation of nitrotyrosine (NTyr).	Nitrogen Dioxide	43-46	gastrin	Homo sapiens	0-3
35549073-4	2022	Taking NO2 and NH3 as target molecules, it is clarified that the bias condition greatly depends on the electron accepting/donating nature of the gas.	Nitrogen Dioxide	7-10	gastrin	Homo sapiens	145-148
35202833-17	2022	Pre-treatment of endothelial cells with NO2- reduces the pro-coagulant activity of EVs via a mechanism that is Hypoxia-inducible factor 1 (HIF-1) dependent, but independent of TF/TFPI.	Nitrogen Dioxide	40-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-137
35404578-2	2022	Besides the great contribution of the conventional  O2- reactive species, a synergic effect between a singlet oxygen (1O2) and mobile hydroxyl radicals ( OHf) was first illustrated for removing NOx indoor gas (1O2 + 2NO   2NO2, NO2 +  OHf   HNO3), inhibiting the production of the byproducts of NO2.	Nitrogen Dioxide	295-298	gastrin	Homo sapiens	205-208
35202833-17	2022	Pre-treatment of endothelial cells with NO2- reduces the pro-coagulant activity of EVs via a mechanism that is Hypoxia-inducible factor 1 (HIF-1) dependent, but independent of TF/TFPI.	Nitrogen Dioxide	40-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-144
35147519-4	2022	It is shown the MoSe2-based nanomaterials have excellent selectivity to Nitrogen dioxide (NO2) according to gas sensing properties measurement.	Nitrogen Dioxide	90-93	gastrin	Homo sapiens	108-111
35430275-5	2022	Our results showed that gestational NO2 exposure significantly aggravated placental fibrosis and calcification, and up-regulated the related bio-markers (connective tissue growth factor (Ctgf) and transforming growth factor-beta1 (Tgf-beta1)) at E18.5.	Nitrogen Dioxide	36-39	cellular communication network factor 2	Mus musculus	154-185
35430275-5	2022	Our results showed that gestational NO2 exposure significantly aggravated placental fibrosis and calcification, and up-regulated the related bio-markers (connective tissue growth factor (Ctgf) and transforming growth factor-beta1 (Tgf-beta1)) at E18.5.	Nitrogen Dioxide	36-39	cellular communication network factor 2	Mus musculus	187-191
35430275-5	2022	Our results showed that gestational NO2 exposure significantly aggravated placental fibrosis and calcification, and up-regulated the related bio-markers (connective tissue growth factor (Ctgf) and transforming growth factor-beta1 (Tgf-beta1)) at E18.5.	Nitrogen Dioxide	36-39	transforming growth factor, beta 1	Mus musculus	197-229
35430275-5	2022	Our results showed that gestational NO2 exposure significantly aggravated placental fibrosis and calcification, and up-regulated the related bio-markers (connective tissue growth factor (Ctgf) and transforming growth factor-beta1 (Tgf-beta1)) at E18.5.	Nitrogen Dioxide	36-39	transforming growth factor, beta 1	Mus musculus	231-240
35430275-6	2022	In addition, gestational exposure to NO2 also activated senescence related pathway (p53/p21) at E18.5.	Nitrogen Dioxide	37-40	transformation related protein 53, pseudogene	Mus musculus	84-87
35430275-6	2022	In addition, gestational exposure to NO2 also activated senescence related pathway (p53/p21) at E18.5.	Nitrogen Dioxide	37-40	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	88-91
35430275-7	2022	Furthermore, gestational NO2 exposure significantly shortened telomere length at E18.5, and the expression of telomere homeostasis regulation genes telomeric repeat binding factor 1 (Trf1), protection of telomeres 1a (Pot1a) and Pot1b were significantly increased while telomerase reverse transcriptase (Tert) was suppressed after NO2 exposure at E13.5 or E18.5, respectively.	Nitrogen Dioxide	25-28	telomeric repeat binding factor 1	Mus musculus	148-181
35430275-7	2022	Furthermore, gestational NO2 exposure significantly shortened telomere length at E18.5, and the expression of telomere homeostasis regulation genes telomeric repeat binding factor 1 (Trf1), protection of telomeres 1a (Pot1a) and Pot1b were significantly increased while telomerase reverse transcriptase (Tert) was suppressed after NO2 exposure at E13.5 or E18.5, respectively.	Nitrogen Dioxide	25-28	telomeric repeat binding factor 1	Mus musculus	183-187
35430275-7	2022	Furthermore, gestational NO2 exposure significantly shortened telomere length at E18.5, and the expression of telomere homeostasis regulation genes telomeric repeat binding factor 1 (Trf1), protection of telomeres 1a (Pot1a) and Pot1b were significantly increased while telomerase reverse transcriptase (Tert) was suppressed after NO2 exposure at E13.5 or E18.5, respectively.	Nitrogen Dioxide	25-28	protection of telomeres 1A	Mus musculus	190-216
35430275-7	2022	Furthermore, gestational NO2 exposure significantly shortened telomere length at E18.5, and the expression of telomere homeostasis regulation genes telomeric repeat binding factor 1 (Trf1), protection of telomeres 1a (Pot1a) and Pot1b were significantly increased while telomerase reverse transcriptase (Tert) was suppressed after NO2 exposure at E13.5 or E18.5, respectively.	Nitrogen Dioxide	25-28	protection of telomeres 1A	Mus musculus	218-223
35430275-7	2022	Furthermore, gestational NO2 exposure significantly shortened telomere length at E18.5, and the expression of telomere homeostasis regulation genes telomeric repeat binding factor 1 (Trf1), protection of telomeres 1a (Pot1a) and Pot1b were significantly increased while telomerase reverse transcriptase (Tert) was suppressed after NO2 exposure at E13.5 or E18.5, respectively.	Nitrogen Dioxide	25-28	protection of telomeres 1B	Mus musculus	229-234
35430275-7	2022	Furthermore, gestational NO2 exposure significantly shortened telomere length at E18.5, and the expression of telomere homeostasis regulation genes telomeric repeat binding factor 1 (Trf1), protection of telomeres 1a (Pot1a) and Pot1b were significantly increased while telomerase reverse transcriptase (Tert) was suppressed after NO2 exposure at E13.5 or E18.5, respectively.	Nitrogen Dioxide	25-28	telomerase reverse transcriptase	Mus musculus	270-302
35430275-7	2022	Furthermore, gestational NO2 exposure significantly shortened telomere length at E18.5, and the expression of telomere homeostasis regulation genes telomeric repeat binding factor 1 (Trf1), protection of telomeres 1a (Pot1a) and Pot1b were significantly increased while telomerase reverse transcriptase (Tert) was suppressed after NO2 exposure at E13.5 or E18.5, respectively.	Nitrogen Dioxide	25-28	telomerase reverse transcriptase	Mus musculus	304-308
35424653-4	2022	This is mainly attributed to the existence of NO2 and NO in the molten NaNO3-NaCl-NaF vapor determined by thermogravimetric infrared spectroscopy, which affected the adherence between oxides and the matrix.	Nitrogen Dioxide	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
35269826-6	2022	We found that oxidative muscles with a higher content of ETC-proteins and myoglobin (such as the heart and slow-twitch locomotory muscles) have lower (NO2-) compared to fast-twitch muscles with a lower content of those proteins.	Nitrogen Dioxide	151-155	myoglobin	Rattus norvegicus	74-83
35440750-10	2022	Resistin increased only significantly (p < 0.001) after running, and Coll2-1 NO2 increased significantly (p = 0.001) only after jumping.	Nitrogen Dioxide	77-80	semaphorin 3D	Homo sapiens	69-74
35344324-0	2022	Temperature-Dependent n-p-n Switching and Highly Selective Room-Temperature n-SnSe2/p-SnO/n-SnSe Heterojunction-Based NO2 Gas Sensor.	Nitrogen Dioxide	118-121	strawberry notch homolog 1	Homo sapiens	86-89
35344324-3	2022	We employed the thermal evaporation method to deposit an n-SnSe2/p-SnO/n-SnSe heterojunction and observed a temperature-dependent n-p-n switching NO2 gas sensor with high selectivity working at room temperature (RT).	Nitrogen Dioxide	146-149	strawberry notch homolog 1	Homo sapiens	67-70
35266499-6	2022	In this review, we discuss the active site environment, electronic structure, spectroscopic and electrochemical properties, and some interesting reactivities exhibited by the heme-Cu-Abeta complex with small molecules, such as oxygen (O2), nitric oxide (NO) and nitrite (NO2-).	Nitrogen Dioxide	271-275	amyloid beta precursor protein	Homo sapiens	183-188
35147519-9	2022	This work demonstrates a promising guidance for the design of new NO2 gas sensing materials and devices.	Nitrogen Dioxide	66-69	gastrin	Homo sapiens	70-73
35133597-8	2022	NO2 concentrations were also negatively related with the number of CD45, CD3, and CD4 cells.	Nitrogen Dioxide	0-3	protein tyrosine phosphatase receptor type C	Homo sapiens	67-71
35167295-6	2022	The CenO2n+1N+ species are regarded as intermediates of the NO oxidation reaction CenO2n+ + NO   CenO2n-1+ + NO2, and therefore, the present results are helpful for understanding redox reactions involving gas-phase CenO2n+ cluster ions.	Nitrogen Dioxide	109-112	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	205-208
35143171-0	2022	Amplitude-Modulated Cavity-Enhanced Absorption Spectroscopy with Phase-Sensitive Detection: A New Approach Applied to the Fast and Sensitive Detection of NO2.	Nitrogen Dioxide	154-157	Fas activated serine/threonine kinase	Homo sapiens	122-126
35144246-4	2022	It is shown the MoSe2-based nanomaterials have excellent selectivity to Nitrogen dioxide (NO2) according to gas sensing properties measurement.	Nitrogen Dioxide	90-93	gastrin	Homo sapiens	108-111
35144246-9	2022	This work demonstrates a promising guidance for the design of new NO2 gas sensing materials and devices.	Nitrogen Dioxide	66-69	gastrin	Homo sapiens	70-73
35133597-8	2022	NO2 concentrations were also negatively related with the number of CD45, CD3, and CD4 cells.	Nitrogen Dioxide	0-3	CD4 molecule	Homo sapiens	82-85
35122157-4	2022	The gas sensor achieves a ppb-level of highly selective NO2 sensing, with a response of up to 12.11% at 5 ppm NO2 and a detection range of 50 ppb-5 ppm, while the pressure sensor has an extremely wide linear pressure detection range of 0.14-22.22 kPa and fast response time of 34 ms.	Nitrogen Dioxide	56-59	gastrin	Homo sapiens	4-7
35122157-4	2022	The gas sensor achieves a ppb-level of highly selective NO2 sensing, with a response of up to 12.11% at 5 ppm NO2 and a detection range of 50 ppb-5 ppm, while the pressure sensor has an extremely wide linear pressure detection range of 0.14-22.22 kPa and fast response time of 34 ms.	Nitrogen Dioxide	110-113	gastrin	Homo sapiens	4-7
35212052-8	2022	Increased odds of detected concentrations of IL-10 was found in newborns exposed during whole pregnancy to higher levels of NO2 (OR per 10 microg/m3 increase = 1.30; 95% CI 0.99, 1.69), PM10 (OR per 10 microg/m3 increase = 1.49; 95% CI 0.95, 2.33), and PM2.5 (OR per 5 microg/m3 increase = 1.56; 95% CI 0.97, 2.51).	Nitrogen Dioxide	124-127	interleukin 10	Homo sapiens	45-50
35128037-8	2022	The wastewater analyses confirm the occurrence of nitrate (NO3 -), nitrite (NO2 -), and ammonia (NH4 +), which provide an appropriate condition for NO2 release.	Nitrogen Dioxide	148-151	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
35055236-3	2022	The CO and NH3 bonding to CoTPP does not influence the Co local electronic structure, while the NO (NO2 and O2) coordination induces a Co reduction (oxidation), generating a 3d8 CoI (3d6 CoIII) magnetically silent closed-shell species.	Nitrogen Dioxide	100-103	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	187-192
34981110-3	2022	Herein, we reported the direct photolysis and NO2--sensitized indirect photolysis of four phenolic contaminants commonly observed in wastewaters (i.e., bisphenol A (BPA), acetaminophen (ATP), salbutamol (SAL), and 2,4-dihydroxybenzophenone (BP1)).	Nitrogen Dioxide	46-49	BP1	Homo sapiens	241-244
34981110-11	2022	Wastewater constituents, such as NO3- and EfOM, could accelerate direct and NO2--sensitized photolysis of BPA, SAL, and BP1 in the wastewater matrix.	Nitrogen Dioxide	76-79	BP1	Homo sapiens	120-123
34908040-2	2022	Herein, Cu2O particles self-supported on Cu foam with enriched oxygen vacancies are developed to enable selective NO2- reduction to NH3, exhibiting a maximum NH3 yield rate of 7510.73 mug h-1 cm-2 and high faradaic efficiency of 94.21% at -0.6 V in 0.1 M PBS containing 0.1 M NaNO2.	Nitrogen Dioxide	114-117	H1.5 linker histone, cluster member	Homo sapiens	188-196
2484060-6	1989	However, exposure to continuous 0.60 ppm NO2 was associated with increases in lavage fluid levels of the antiprotease alpha-2-macroglobulin (alpha 2M) when assessed 3.5 h after exposure (air versus NO2: 20 +/- 1 versus 29 +/- 2 ng/ml, P = 0.01).	Nitrogen Dioxide	41-44	alpha-2-macroglobulin	Homo sapiens	118-139
35010834-1	2022	High NO2 concentrations (long term average of 383 microg/m3 in 2016/2017) recorded at Birmingham New Street railway station have resulted in the upgrade of the bi-directional fan system to aid wind dispersion within the enclosed platform environment.	Nitrogen Dioxide	5-8	activation induced cytidine deaminase	Homo sapiens	189-192
2484060-6	1989	However, exposure to continuous 0.60 ppm NO2 was associated with increases in lavage fluid levels of the antiprotease alpha-2-macroglobulin (alpha 2M) when assessed 3.5 h after exposure (air versus NO2: 20 +/- 1 versus 29 +/- 2 ng/ml, P = 0.01).	Nitrogen Dioxide	41-44	alpha-2-macroglobulin	Homo sapiens	141-149
2484060-6	1989	However, exposure to continuous 0.60 ppm NO2 was associated with increases in lavage fluid levels of the antiprotease alpha-2-macroglobulin (alpha 2M) when assessed 3.5 h after exposure (air versus NO2: 20 +/- 1 versus 29 +/- 2 ng/ml, P = 0.01).	Nitrogen Dioxide	198-201	alpha-2-macroglobulin	Homo sapiens	118-139
2484060-6	1989	However, exposure to continuous 0.60 ppm NO2 was associated with increases in lavage fluid levels of the antiprotease alpha-2-macroglobulin (alpha 2M) when assessed 3.5 h after exposure (air versus NO2: 20 +/- 1 versus 29 +/- 2 ng/ml, P = 0.01).	Nitrogen Dioxide	198-201	alpha-2-macroglobulin	Homo sapiens	141-149
2509627-4	1989	In M phi and endothelial cells, citrulline and NO2-/NO3- are the stable endproducts of this metabolic pathway.	Nitrogen Dioxide	47-50	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
24201842-1	1989	The hypothesis of NO2 (-) toxicity as the causative factor of NO3 (-) inhibition of nitrogenase (N2ase; EC 1.18.6.1) activity has been evaluated using a short-term exposure (3 d) of several legumes.	Nitrogen Dioxide	18-21	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
24201842-7	1989	It is concluded that NO2 (-) is not responsible for the initial NO3 (-)-induced decline of N2ase activity, and that toxic amounts of NO2 (-) only build up in nodules following longer exposures to NO3 (-), when this anion is actively reduced by bacteroid and cytosol enzymes.	Nitrogen Dioxide	133-136	NBL1, DAN family BMP antagonist	Homo sapiens	196-199
2548610-4	1989	When both IHP and BZF are added to the mixed-spin derivatives (H2O, SCN-, OCN-, and NO2-) of human methemoglobin, the spin equilibrium is shifted toward higher spin by about 700 cal/mol, similar to the spin change detected in derivatives of carp methemoglobin upon addition of IHP alone.	Nitrogen Dioxide	84-87	hemoglobin subunit gamma 2	Homo sapiens	99-112
2548610-4	1989	When both IHP and BZF are added to the mixed-spin derivatives (H2O, SCN-, OCN-, and NO2-) of human methemoglobin, the spin equilibrium is shifted toward higher spin by about 700 cal/mol, similar to the spin change detected in derivatives of carp methemoglobin upon addition of IHP alone.	Nitrogen Dioxide	84-87	spindlin 1	Homo sapiens	118-122
2548610-4	1989	When both IHP and BZF are added to the mixed-spin derivatives (H2O, SCN-, OCN-, and NO2-) of human methemoglobin, the spin equilibrium is shifted toward higher spin by about 700 cal/mol, similar to the spin change detected in derivatives of carp methemoglobin upon addition of IHP alone.	Nitrogen Dioxide	84-87	spindlin 1	Homo sapiens	118-122
2548610-4	1989	When both IHP and BZF are added to the mixed-spin derivatives (H2O, SCN-, OCN-, and NO2-) of human methemoglobin, the spin equilibrium is shifted toward higher spin by about 700 cal/mol, similar to the spin change detected in derivatives of carp methemoglobin upon addition of IHP alone.	Nitrogen Dioxide	84-87	spindlin 1	Homo sapiens	118-122
2784382-7	1989	Four of nine subjects accounted for the observed impairment in virus inactivation; cells from these four subjects demonstrated an increase in interleukin-1 (IL-1) production after NO2 vs air, whereas the five remaining subjects decreased IL-1 production after NO2.	Nitrogen Dioxide	180-183	interleukin 1 alpha	Homo sapiens	142-161
2787317-1	1989	Previously we demonstrated that in vivo exposure of humans to NO2 resulted in significant inactivation of alpha 1-protease inhibitor (alpha 1-PI) in the bronchoalveolar lavage fluid.	Nitrogen Dioxide	62-65	serpin family A member 1	Homo sapiens	106-132
2787317-1	1989	Previously we demonstrated that in vivo exposure of humans to NO2 resulted in significant inactivation of alpha 1-protease inhibitor (alpha 1-PI) in the bronchoalveolar lavage fluid.	Nitrogen Dioxide	62-65	serpin family A member 1	Homo sapiens	134-144
2787317-2	1989	However, alpha 1-PI retains its elastase inhibitory activity in vitro when exposed to 10 times the concentration of NO2 used in vivo.	Nitrogen Dioxide	116-119	serpin family A member 1	Homo sapiens	9-19
2787317-5	1989	alpha 1-PI in solutions containing phosphate buffer (control), 0.1 mM stearic acid (saturated fatty acid, 18:0), or 0.1 mM linoleic acid (polyunsaturated fatty acid, 18:2) was exposed to either N2 or NO2 (50 ppm for 4 h).	Nitrogen Dioxide	200-203	serpin family A member 1	Homo sapiens	0-10
2787317-6	1989	Elastase inhibitory capacity of alpha 1-PI was significantly diminished in the presence of 0.1 mM linoleic acid and under NO2 atmosphere (75 +/- 8% of control, P less than 0.01), whereas there was no change in elastase inhibitory capacity of alpha 1-PI in the presence or absence (buffer only) of 0.1 mM stearic acid under a similar condition (109 +/- 11 and 94 +/- 6%, respectively).	Nitrogen Dioxide	122-125	serpin family A member 1	Homo sapiens	32-42
2784382-7	1989	Four of nine subjects accounted for the observed impairment in virus inactivation; cells from these four subjects demonstrated an increase in interleukin-1 (IL-1) production after NO2 vs air, whereas the five remaining subjects decreased IL-1 production after NO2.	Nitrogen Dioxide	180-183	interleukin 1 alpha	Homo sapiens	157-161
2495581-2	1989	The lung cytochrome P-450 decreased significantly after 1-week exposures to 10 and 15 ppm NO2 and showed a decreasing tendency after 2-week exposures to 6-10 ppm NO2.	Nitrogen Dioxide	90-93	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	9-25
2784476-15	1989	and/or a closely related, highly reactive nitrogen oxide such as NO2, during their conversion of L-arginine to NO2-/NO3-.	Nitrogen Dioxide	65-68	NBL1, DAN family BMP antagonist	Mus musculus	116-119
2784476-15	1989	and/or a closely related, highly reactive nitrogen oxide such as NO2, during their conversion of L-arginine to NO2-/NO3-.	Nitrogen Dioxide	111-114	NBL1, DAN family BMP antagonist	Mus musculus	116-119
2787909-3	1989	When X = dansyl and R = Phe(NO2) the substrate was suited for continuous fluorimetric assay of rat brain cathepsin L (Km 45 microM, kcat/Km 1333 mM-1 sec-1).	Nitrogen Dioxide	28-31	cathepsin L	Rattus norvegicus	105-116
2787909-3	1989	When X = dansyl and R = Phe(NO2) the substrate was suited for continuous fluorimetric assay of rat brain cathepsin L (Km 45 microM, kcat/Km 1333 mM-1 sec-1).	Nitrogen Dioxide	28-31	secretory blood group 1	Rattus norvegicus	150-155
2495581-2	1989	The lung cytochrome P-450 decreased significantly after 1-week exposures to 10 and 15 ppm NO2 and showed a decreasing tendency after 2-week exposures to 6-10 ppm NO2.	Nitrogen Dioxide	162-165	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	9-25
2495581-3	1989	On the other hand, the cytochrome b5, NADPH-cytochrome P-450 reductase and NADH-cytochrome b5 reductase of lung microsomes were increased concomitant with increase in microsomal proteins during 2-week exposures to 6-10 ppm NO2.	Nitrogen Dioxide	223-226	cytochrome b5 type A	Rattus norvegicus	23-36
2495581-3	1989	On the other hand, the cytochrome b5, NADPH-cytochrome P-450 reductase and NADH-cytochrome b5 reductase of lung microsomes were increased concomitant with increase in microsomal proteins during 2-week exposures to 6-10 ppm NO2.	Nitrogen Dioxide	223-226	cytochrome p450 oxidoreductase	Rattus norvegicus	38-70
2495581-4	1989	These results show that the lung cytochrome P-450 decreases preferentially upon exposure to NO2 at higher concentrations.	Nitrogen Dioxide	92-95	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	33-49
2559883-2	1989	NO2 is a strongly oxidizing toxicant, although NO, not oxidizing as NO2, is toxic in that it interacts with hemoglobin to form nitrosyl- and methemoglobin.	Nitrogen Dioxide	0-3	hemoglobin subunit gamma 2	Homo sapiens	141-154
2484692-12	1989	In accordance with an autocatalytic process, O2- further enhances sydnonimine decomposition, since in the presence of superoxide dismutase (SOD) the rate of SIN-1C and NO2-/NO3- formation from SIN-1A was reduced, whereas the rate of NO liberation seemingly increased.	Nitrogen Dioxide	168-171	superoxide dismutase 1	Homo sapiens	118-138
2484692-12	1989	In accordance with an autocatalytic process, O2- further enhances sydnonimine decomposition, since in the presence of superoxide dismutase (SOD) the rate of SIN-1C and NO2-/NO3- formation from SIN-1A was reduced, whereas the rate of NO liberation seemingly increased.	Nitrogen Dioxide	168-171	superoxide dismutase 1	Homo sapiens	140-143
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Nitrogen Dioxide	116-119	interferon gamma	Mus musculus	12-28
3049064-0	1988	Effects of in vitro exposure to nitrogen dioxide on human alveolar macrophage release of neutrophil chemotactic factor and interleukin-1.	Nitrogen Dioxide	32-48	neutrophil cytosolic factor 4	Homo sapiens	89-118
3242600-5	1988	Nitric oxide formation was dependent on the presence of L-arginine and NADPH and was inhibited by the NO2-/NO3- synthesis inhibitor NG-monomethyl-L-arginine.	Nitrogen Dioxide	102-105	NBL1, DAN family BMP antagonist	Mus musculus	107-110
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Nitrogen Dioxide	116-119	interferon gamma	Rattus norvegicus	30-40
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Nitrogen Dioxide	116-119	tumor necrosis factor	Mus musculus	58-79
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Nitrogen Dioxide	116-119	tumor necrosis factor	Rattus norvegicus	81-85
3139757-4	1988	Of these, only IFN-gamma induced substantial NO2- secretion during the culture period.	Nitrogen Dioxide	45-48	interferon gamma	Mus musculus	15-24
3139757-6	1988	Incubation of macrophages with IFN-gamma for 48 h in the presence of LPS inhibited H2O2 production but augmented NO2- release, whereas incubation in the presence of the arginine analog NG-monomethylarginine inhibited NO2- release but not H2O2 production.	Nitrogen Dioxide	113-116	interferon gamma	Mus musculus	31-40
3139757-6	1988	Incubation of macrophages with IFN-gamma for 48 h in the presence of LPS inhibited H2O2 production but augmented NO2- release, whereas incubation in the presence of the arginine analog NG-monomethylarginine inhibited NO2- release but not H2O2 production.	Nitrogen Dioxide	217-220	interferon gamma	Mus musculus	31-40
3139757-8	1988	Moreover, IFN-alpha or IFN-beta in combination with LPS could also induce NO2- production in macrophages, as was previously reported for IFN-gamma plus LPS.	Nitrogen Dioxide	74-77	interferon alpha	Mus musculus	10-19
3139757-8	1988	Moreover, IFN-alpha or IFN-beta in combination with LPS could also induce NO2- production in macrophages, as was previously reported for IFN-gamma plus LPS.	Nitrogen Dioxide	74-77	interferon beta 1, fibroblast	Mus musculus	23-31
3139757-9	1988	These data suggest that: 1) tested as a sole agent, IFN-gamma was the only one of the 12 cytokines capable of inducing both NO2- and H2O2 release; 2) the pathways leading to secretion of H2O2 and NO2- are independent; 3) either IFN-gamma and TNF-alpha/beta or IFN-alpha/beta/gamma and LPS can interact synergistically to induce NO2- release.	Nitrogen Dioxide	124-127	interferon gamma	Mus musculus	52-61
3139757-9	1988	These data suggest that: 1) tested as a sole agent, IFN-gamma was the only one of the 12 cytokines capable of inducing both NO2- and H2O2 release; 2) the pathways leading to secretion of H2O2 and NO2- are independent; 3) either IFN-gamma and TNF-alpha/beta or IFN-alpha/beta/gamma and LPS can interact synergistically to induce NO2- release.	Nitrogen Dioxide	196-199	interferon gamma	Mus musculus	52-61
3139757-9	1988	These data suggest that: 1) tested as a sole agent, IFN-gamma was the only one of the 12 cytokines capable of inducing both NO2- and H2O2 release; 2) the pathways leading to secretion of H2O2 and NO2- are independent; 3) either IFN-gamma and TNF-alpha/beta or IFN-alpha/beta/gamma and LPS can interact synergistically to induce NO2- release.	Nitrogen Dioxide	196-199	interferon gamma	Mus musculus	52-61
3358780-2	1988	We evaluated the ability of NO2 to alter the surface membrane fluidity, lipid composition, and insulin receptor binding of porcine pulmonary artery endothelial cells in culture.	Nitrogen Dioxide	28-31	insulin receptor	Homo sapiens	95-111
2851879-5	1988	The marked enrichment of H+, SO4(2-) and NO3- in precipitation compared with NH4+ could be explained by assuming either that SO2 and NO2 are oxidized in cloud droplets or that acidic sulfate and nitrate are scavenged directly in-cloud or below-cloud.	Nitrogen Dioxide	133-136	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
3221192-5	1988	The effect of NO3- on methanogenesis was twofold: firstly, H2 accumulation decreased due to diversion of electrons towards NO3-/NO2- reduction, and as a result of H2 being used as an electron donor for NO3- reduction, resulting in the removal of the methanogenic substrate; secondly, there was direct inhibition of methane-producing bacteria by NO3- and NO2-.	Nitrogen Dioxide	128-131	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
3221192-5	1988	The effect of NO3- on methanogenesis was twofold: firstly, H2 accumulation decreased due to diversion of electrons towards NO3-/NO2- reduction, and as a result of H2 being used as an electron donor for NO3- reduction, resulting in the removal of the methanogenic substrate; secondly, there was direct inhibition of methane-producing bacteria by NO3- and NO2-.	Nitrogen Dioxide	354-357	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
3358780-10	1988	Scatchard analysis of the binding data indicated that NO2 exposure caused a 5-fold reduction in insulin receptor binding sites in endothelial cells.	Nitrogen Dioxide	54-57	insulin receptor	Homo sapiens	96-112
3345578-3	1988	In open, aerobic systems the effective stoichiometry of the reaction between ASC and nitrite is not fixed, but is determined by a competition between the physical removal of NO (and NO2) from the system and the oxidation of NO by dissolved O2.	Nitrogen Dioxide	182-185	PYD and CARD domain containing	Homo sapiens	77-80
3498415-0	1987	Acute effect of nitrogen dioxide exposure on the functional activity of alpha-1-protease inhibitor in bronchoalveolar lavage fluid of normal subjects.	Nitrogen Dioxide	16-32	serpin family A member 1	Homo sapiens	72-98
24430791-3	1988	We find that anions such as NO3 (-), HCO3 (-), HCO2 (-), F(-), NO2 (-), and acetate can, depending on conditions, bind to either anion binding-site I, anion binding-site II, or both sites simultaneously.	Nitrogen Dioxide	63-66	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
2827739-4	1987	Interconversion of the ferrous LPO/NO complex and the ferric LPO/NO2- complex is achieved by addition of the appropriate oxidizing or reducing agent.	Nitrogen Dioxide	65-68	lactoperoxidase	Homo sapiens	31-34
2827739-4	1987	Interconversion of the ferrous LPO/NO complex and the ferric LPO/NO2- complex is achieved by addition of the appropriate oxidizing or reducing agent.	Nitrogen Dioxide	65-68	lactoperoxidase	Homo sapiens	61-64
3341628-2	1988	We evaluated the effect of beta-aminopropionitrile (beta APN) on the nitrogen dioxide (NO2) animal model of emphysema.	Nitrogen Dioxide	69-85	alanyl aminopeptidase, membrane	Rattus norvegicus	57-60
3498415-2	1987	We examined the effect of NO2 exposure on the functional activity against pancreatic elastase of alpha-1-protease inhibitor (alpha 1PI) in bronchoalveolar lavage (BAL) fluid of nonsmoking subjects.	Nitrogen Dioxide	26-29	serpin family A member 1	Homo sapiens	97-123
3498415-2	1987	We examined the effect of NO2 exposure on the functional activity against pancreatic elastase of alpha-1-protease inhibitor (alpha 1PI) in bronchoalveolar lavage (BAL) fluid of nonsmoking subjects.	Nitrogen Dioxide	26-29	serpin family A member 1	Homo sapiens	125-134
3498415-6	1987	Exposure to NO2 caused a 45% decrease in functional activity of alpha 1PI in BAL.	Nitrogen Dioxide	12-15	serpin family A member 1	Homo sapiens	64-73
3498415-11	1987	These results showed that nonsmoking subjects exposed to relatively low concentrations of NO2 for a short time have a significant inactivation of alpha 1PI in the lower respiratory tract fluid than did nonsmoking control subjects.	Nitrogen Dioxide	90-93	serpin family A member 1	Homo sapiens	146-155
2822381-7	1987	The results suggest that during the oxidation, the methemoglobin peroxide compound is generated and converts nitrite into nitrogen dioxide by its peroxidatic activity.	Nitrogen Dioxide	122-138	hemoglobin subunit gamma 2	Homo sapiens	51-64
3318552-1	1987	The action of bovine spleen cathepsin B as a dipeptidyl carboxypeptidase on newly synthesized substrates of the type peptidyl-X-p-nitrophenylalanyl (Phe(NO2))-Y (X,Y = amino acid residue) or 5-dimethylaminonaphthalene-1-sulfonyl (Dns)-peptidyl-X-Phe(NO2)-Y was investigated.	Nitrogen Dioxide	153-156	cathepsin B	Bos taurus	28-39
3318552-1	1987	The action of bovine spleen cathepsin B as a dipeptidyl carboxypeptidase on newly synthesized substrates of the type peptidyl-X-p-nitrophenylalanyl (Phe(NO2))-Y (X,Y = amino acid residue) or 5-dimethylaminonaphthalene-1-sulfonyl (Dns)-peptidyl-X-Phe(NO2)-Y was investigated.	Nitrogen Dioxide	250-253	cathepsin B	Bos taurus	28-39
2444033-0	1987	[Serum alpha 1-antitrypsin and alpha 2-macroglobulin levels in persons exposed to benzene, hydrogen cyanide, sulfur dioxide and nitrogen dioxide].	Nitrogen Dioxide	128-144	serpin family A member 1	Homo sapiens	7-26
2444033-0	1987	[Serum alpha 1-antitrypsin and alpha 2-macroglobulin levels in persons exposed to benzene, hydrogen cyanide, sulfur dioxide and nitrogen dioxide].	Nitrogen Dioxide	128-144	alpha-2-macroglobulin	Homo sapiens	31-52
3088440-4	1986	When 90 microliter/l NO2 gas was bubbled into bacterial suspensions for 30 min at a flow rate of 100 ml/min, the induction of umuC gene expression increased in the wild-type strain.	Nitrogen Dioxide	21-24	DNA polymerase V subunit UmuC	Escherichia coli	126-130
3106644-3	1987	Cells preincubated with arachidonic acid (20:4) complexed to bovine serum albumin (BSA) demonstrated an increased in vitro sensitivity versus ozone and nitrogen dioxide.	Nitrogen Dioxide	152-168	albumin	Rattus norvegicus	68-81
2478162-9	1987	Exposure of the cells to 3 or 5 ppm NO2 for 24 hours resulted in significant increases in GSH-red (p less than 0.05) and G6PDH (p less than 0.001) activities in both cell types.	Nitrogen Dioxide	36-39	glucose-6-phosphate dehydrogenase	Homo sapiens	121-126
3019657-2	1986	In the lung, cytochrome P-450 decreased to 59% (P less than 0.01) and 57% (P less than 0.01) of the control values after 1 and 10 weeks of exposure to 4.0 ppm NO2, respectively, and remained at control levels at other exposure periods.	Nitrogen Dioxide	159-162	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	13-29
3019657-5	1986	In the liver, cytochrome P-450 decreased to 72% (P less than 0.01), 70% (P less than 0.05), and 73% (P less than 0.05) of the control values after 1, 5, and 8 weeks of exposure to 4.0 ppm NO2, respectively, and remained at control levels at other exposure periods.	Nitrogen Dioxide	188-191	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	14-30
3019657-8	1986	In addition, cytochrome b5 showed a reduced value between 5 and 12 weeks of exposures to 1.2 and 4.0 ppm NO2 and then recovered.	Nitrogen Dioxide	105-108	cytochrome b5 type A	Rattus norvegicus	13-26
3019657-10	1986	These results show that subacute exposures to 0.4-4.0 ppm NO2 caused a periodic reduction in microsomal cytochrome P-450 and mitochondrial succinate-cytochrome c reductase in the lung and in components of the microsomal electron-transport systems in the liver, whereas exposures to 1.2 and 4.0 ppm NO2 resulted in induction of the microsomal electron-transport systems in the kidney.	Nitrogen Dioxide	58-61	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	104-171
3019657-10	1986	These results show that subacute exposures to 0.4-4.0 ppm NO2 caused a periodic reduction in microsomal cytochrome P-450 and mitochondrial succinate-cytochrome c reductase in the lung and in components of the microsomal electron-transport systems in the liver, whereas exposures to 1.2 and 4.0 ppm NO2 resulted in induction of the microsomal electron-transport systems in the kidney.	Nitrogen Dioxide	298-301	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	104-171
3268287-0	1987	Effects of ozone and nitrogen dioxide on human lung proteinase inhibitors.	Nitrogen Dioxide	21-37	endogenous retrovirus group K member 18	Homo sapiens	52-62
3268287-13	1987	In vitro exposure of alpha 1-PI and BLPI to 800 moles of NO2 per mole of inhibitor resulted in 35% and 50% losses of HNE inhibitory activity, respectively.	Nitrogen Dioxide	57-60	secretory leukocyte peptidase inhibitor	Homo sapiens	36-40
3775782-5	1986	Exposure to 3 or 5 ppm NO2 for 24 h resulted in significant increases in GSH-red (P less than 0.05) and G6PDH (P less than 0.001) activities in both cell types.	Nitrogen Dioxide	23-26	glucose-6-phosphate dehydrogenase	Homo sapiens	104-109
3775782-7	1986	These results indicate that enzyme activities of G6PDH and GSH-red are increased in PA and AO endothelial cells exposed to NO2, and this response is comparable, in part, to that in the lungs from animals exposed to NO2.	Nitrogen Dioxide	123-126	glucose-6-phosphate dehydrogenase	Homo sapiens	49-54
3775782-7	1986	These results indicate that enzyme activities of G6PDH and GSH-red are increased in PA and AO endothelial cells exposed to NO2, and this response is comparable, in part, to that in the lungs from animals exposed to NO2.	Nitrogen Dioxide	215-218	glucose-6-phosphate dehydrogenase	Homo sapiens	49-54
3963886-2	1986	Daily average of the personal NO2 exposure (ENO2) was measured during wintertime by a newly developed personal monitor exposed for 24 hours.	Nitrogen Dioxide	30-33	enolase 2	Homo sapiens	44-48
3836241-7	1985	The autocatalytic stage for hemoglobin oxidation results from nitrogen dioxide formed from nitrite through the peroxidase activity of methemoglobin.	Nitrogen Dioxide	62-78	hemoglobin subunit gamma 2	Homo sapiens	134-147
3839996-1	1985	The xanthine oxidase reaction causes a co-oxidation of NH3 to NO2-, which was inhibitable by superoxide dismutase, catalase, hydroxyl radical scavengers, or by the chelating agents, desferrioxamine or diethylene triaminepentaacetic acid.	Nitrogen Dioxide	62-65	catalase	Homo sapiens	115-123
3839996-2	1985	Hydroxylamine was oxidized to NO2- much more rapidly than was NH3, and in this case superoxide dismutase or the chelating agents inhibited but catalase or the HO.	Nitrogen Dioxide	30-33	catalase	Homo sapiens	143-151
3929434-5	1985	In contrast, exposure to 1.2 and 4 ppm NO2 decreased cytochrome P-450 on the 7th day.	Nitrogen Dioxide	39-42	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	53-69
3859354-5	1985	Prostaglandin (PG)F2, a universal vasoconstrictor, produced an effect similar to that by AII on neuronal activity of the SFO and surrounding regions, and this effect was antagonized by (NO2-), a vasoplegic agent.	Nitrogen Dioxide	186-189	angiotensinogen	Rattus norvegicus	89-92
3859354-9	1985	Simultaneous intraventricular application of NO2- blocked the AII effect on SFO neurons but not on blood pressure.	Nitrogen Dioxide	45-48	angiotensinogen	Rattus norvegicus	62-65
2860597-5	1985	Replacement of D-Arg2 by D-Arg(NO2), D-homoarginine or D-Lys resulted in a decrease in potency, suggesting that the guanidino group and side chain length of D-Arg2 are of great importance for a higher activity.	Nitrogen Dioxide	31-34	arginase type II	Mus musculus	17-21
2860597-5	1985	Replacement of D-Arg2 by D-Arg(NO2), D-homoarginine or D-Lys resulted in a decrease in potency, suggesting that the guanidino group and side chain length of D-Arg2 are of great importance for a higher activity.	Nitrogen Dioxide	31-34	arginase type II	Mus musculus	159-163
3883144-0	1985	Induction of umuC gene expression by nitrogen dioxide in Salmonella typhimurium.	Nitrogen Dioxide	37-53	DNA polymerase V subunit UmuC	Salmonella enterica subsp. enterica serovar Typhimurium	13-17
3883144-1	1985	Gaseous nitrogen dioxide (NO2) was found to induce umuC gene expression in Salmonella typhimurium carrying the umuC-lacZ fusion plasmid.	Nitrogen Dioxide	8-24	DNA polymerase V subunit UmuC	Salmonella enterica subsp. enterica serovar Typhimurium	51-55
3883144-1	1985	Gaseous nitrogen dioxide (NO2) was found to induce umuC gene expression in Salmonella typhimurium carrying the umuC-lacZ fusion plasmid.	Nitrogen Dioxide	8-24	DNA polymerase V subunit UmuC	Salmonella enterica subsp. enterica serovar Typhimurium	111-115
3883144-1	1985	Gaseous nitrogen dioxide (NO2) was found to induce umuC gene expression in Salmonella typhimurium carrying the umuC-lacZ fusion plasmid.	Nitrogen Dioxide	26-29	DNA polymerase V subunit UmuC	Salmonella enterica subsp. enterica serovar Typhimurium	51-55
3883144-1	1985	Gaseous nitrogen dioxide (NO2) was found to induce umuC gene expression in Salmonella typhimurium carrying the umuC-lacZ fusion plasmid.	Nitrogen Dioxide	26-29	DNA polymerase V subunit UmuC	Salmonella enterica subsp. enterica serovar Typhimurium	111-115
3883144-4	1985	Expression of the umuC gene varied with the concentration, flow rate and bubbling time of the NO2 gas.	Nitrogen Dioxide	94-97	DNA polymerase V subunit UmuC	Salmonella enterica subsp. enterica serovar Typhimurium	18-22
4057678-0	1985	[Changes in the content and activity of hepatic cytochrome P-450 in rats exposed to nitrogen dioxide for 30 days].	Nitrogen Dioxide	84-100	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	48-64
3159909-6	1985	The glucose-6-phosphate dehydrogenase activity of exposed animals increased significantly at d 3, 4, and 14 of exposures to 10, 4, and 2 ppm NO2, respectively, and a significantly higher value was maintained in the following period of exposure.	Nitrogen Dioxide	141-144	glucose-6-phosphate dehydrogenase	Rattus norvegicus	4-37
6515658-0	1984	Combined effect of nitrogen dioxide and cold stress on the activity of the hepatic cytochrome P-450 system in rats.	Nitrogen Dioxide	19-35	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	83-99
6515658-1	1984	The combined effects of nitrogen dioxide (NO2) and cold stress were assessed on the cytochrome P-450 system by measuring microsomal protein content, cytochrome P-450 content, aminopyrine N-demethylase activity, and aniline hydroxylase activity in the liver of male Wistar rats exposed to 4 ppm NO2 and/or cold environment (4 degrees C) for 24 h, 14 days, and 30 days.	Nitrogen Dioxide	24-40	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	84-100
6515658-1	1984	The combined effects of nitrogen dioxide (NO2) and cold stress were assessed on the cytochrome P-450 system by measuring microsomal protein content, cytochrome P-450 content, aminopyrine N-demethylase activity, and aniline hydroxylase activity in the liver of male Wistar rats exposed to 4 ppm NO2 and/or cold environment (4 degrees C) for 24 h, 14 days, and 30 days.	Nitrogen Dioxide	42-45	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	84-100
6515658-3	1984	Interactions were observed in the effect on the cytochrome P-450 system when rats were exposed to NO2 and cold simultaneously.	Nitrogen Dioxide	98-101	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	48-64
6515658-4	1984	There was a tendency that NO2 suppressed the increases in activities of the cytochrome P-450 system caused by cold of 24-h and 30-day exposure.	Nitrogen Dioxide	26-29	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	76-92
6395137-7	1984	Exposure to NO2 for 10 consecutive days resulted in inhibition of cytoplasmic L-ALDH.	Nitrogen Dioxide	12-15	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	80-84
6319120-5	1984	The NADPH-cytochrome c reductase activity and the cytochrome P-450 content were decreased to 82% (P less than 0.05) and 76% (P less than 0.05), respectively, at the fifth day of exposure to 10 ppm NO2.	Nitrogen Dioxide	197-200	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	50-66
6319120-6	1984	Exposure to 4 ppm NO2 also caused a significant decrease in the NADPH-cytochrome c reductase and the cytochrome P-450 content, which were lowered to 84% (P less than 0.05) of the control level at the fourth and seventh days, respectively.	Nitrogen Dioxide	18-21	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	101-117
6437448-2	1984	Steady-state kinetic parameters for the hydrolysis of the chromophoric hexapeptide Leu-Ser-Phe(NO2)-Nle-Ala-Leu-OMe catalyzed by bovine gastricsin and pepsin A were determined.	Nitrogen Dioxide	95-99	progastricsin	Bos taurus	136-146
6437448-2	1984	Steady-state kinetic parameters for the hydrolysis of the chromophoric hexapeptide Leu-Ser-Phe(NO2)-Nle-Ala-Leu-OMe catalyzed by bovine gastricsin and pepsin A were determined.	Nitrogen Dioxide	95-99	pepsin A	Bos taurus	151-159
7209517-3	1981	We found rapid in vivo oxidation of NO2- to NO3- at concentrations of 2 to 3 nanomoles per liter in blood.	Nitrogen Dioxide	36-39	NBL1, DAN family BMP antagonist	Mus musculus	44-47
6303331-1	1983	Through chemistry directly comparable to that of the hemocyanins and tyrosinase, half met-NO2- T2D laccase derivatives have been prepared; this NO2- reactivity entails both two electron oxidation of the cuprous binuclear site in deoxy T2D laccase and one electron reduction of the coupled cupric site in the met derivative.	Nitrogen Dioxide	90-93	tyrosinase	Homo sapiens	69-79
6832114-0	1983	In vitro methemoglobin formation in human blood exposed to NO2.	Nitrogen Dioxide	59-62	hemoglobin subunit gamma 2	Homo sapiens	9-22
6832114-1	1983	The in vitro formation of methemoglobin in human blood was determined for various NO2 concentrations and exposure times.	Nitrogen Dioxide	82-85	hemoglobin subunit gamma 2	Homo sapiens	26-39
6658836-7	1983	These results suggest that cytochrome P1-450 system in lung microsomes may have protective action against the toxicity of NO2.	Nitrogen Dioxide	122-125	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	27-44
6342715-2	1983	The responsiveness of these units to angiotensin II (AII) applied either iontophoretically or via the carotid artery (IC) was investigated together with the capacity of the vasodilator substance NO2- to block the AII response.	Nitrogen Dioxide	195-198	angiotensinogen	Homo sapiens	213-216
6206113-1	1981	There has been evidence that an acute exposure of laboratory animals to nitrogen dioxide (NO2) for a short period of time can cause marked inhibition of pulmonary PGDH activity.	Nitrogen Dioxide	72-88	15-hydroxyprostaglandin dehydrogenase	Rattus norvegicus	163-167
6206113-1	1981	There has been evidence that an acute exposure of laboratory animals to nitrogen dioxide (NO2) for a short period of time can cause marked inhibition of pulmonary PGDH activity.	Nitrogen Dioxide	90-93	15-hydroxyprostaglandin dehydrogenase	Rattus norvegicus	163-167
736616-9	1978	Glucose-6-phosphate dehydrogenase was significantly elevated only after the second 2-ppm NO2 exposure.	Nitrogen Dioxide	89-92	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
41590-3	1979	NO2- binds with methemoglobin noncooperatively with a binding constant of 340 M-1 at pH 7.4 and 25 degrees C. Thus, the major part of Hb+ produced is aquomethemoglobin, not methemoglobin nitrite, when less than 2 equivalents of nitrite is used for the oxidation.	Nitrogen Dioxide	0-3	hemoglobin subunit gamma 2	Homo sapiens	16-29
41590-3	1979	NO2- binds with methemoglobin noncooperatively with a binding constant of 340 M-1 at pH 7.4 and 25 degrees C. Thus, the major part of Hb+ produced is aquomethemoglobin, not methemoglobin nitrite, when less than 2 equivalents of nitrite is used for the oxidation.	Nitrogen Dioxide	0-3	hemoglobin subunit gamma 2	Homo sapiens	154-167
475464-3	1979	Analysis of total lung collagen and total lung elastin revealed a net decrease in the moieties within 4 and 10 days, respectively, following commencement of nitrogen dioxide exposure.	Nitrogen Dioxide	157-173	Eln	Mesocricetus auratus	47-54
475464-6	1979	Recovery in room air for 3 wk following 21 days of nitrogen dioxide exposure restored the total pulmonary collagen and elastin to valutin and collagen degradation and synthesis differ during and after nitrogen dioxide exposure.	Nitrogen Dioxide	51-67	Eln	Mesocricetus auratus	119-126
475464-6	1979	Recovery in room air for 3 wk following 21 days of nitrogen dioxide exposure restored the total pulmonary collagen and elastin to valutin and collagen degradation and synthesis differ during and after nitrogen dioxide exposure.	Nitrogen Dioxide	201-217	Eln	Mesocricetus auratus	119-126
104046-3	1978	Similarly, PAM from three of the four NO2-exposed animals had diminished responsiveness to MIF obtained by phytohemagglutinin stimulation of their own lymphocytes.	Nitrogen Dioxide	38-41	macrophage migration inhibitory factor	Cavia porcellus	91-94
581059-3	1978	NO2 significantly increased AHH activity but no marked change was noted with SO2.	Nitrogen Dioxide	0-3	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	28-31
581059-4	1978	Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone.	Nitrogen Dioxide	82-85	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	13-16
16659756-9	1976	Under the latter condition, in vitro NR activity was appreciable (19 mumol NO(2) (-) [g fresh weight, hr](-1)) suggesting that enzyme level per se was not the limiting factor and that reductant energy might be limiting.The addition of NADH to the in vivo NR assay medium did not stimulate NR activity, although it was not established that NADH entered the tissue.	Nitrogen Dioxide	75-80	inducible nitrate reductase [NADH] 1	Glycine max	37-39
1269495-4	1976	Further studies of this observation suggested that ferrous hemoglobin potentiates ozone-induced lipid peroxidation while methemoglobin, resulting primarily from nitrogen dioxide, inhibits this process.	Nitrogen Dioxide	161-177	hemoglobin subunit gamma 2	Homo sapiens	121-134
33923840-0	2021	Magnesium Zirconate Titanate Thin Films Used as an NO2 Sensing Layer for Gas Sensor Applications Developed Using a Sol-Gel Method.	Nitrogen Dioxide	51-54	gastrin	Homo sapiens	73-76
24435078-5	1975	The stoichiometry of alkalinisation and NO3 (-) or NO2 (-) uptake can be quantitatively explained by assuming: 1) a counter-transport, at a ratio of 1:1, of OH(-) against NO3 (-) at the plasmalemma and of OH(-) against NO2 (-) at the chloroplast envelope, and 2) a co-transport of 1:1 of OH(-) and NH4 (+) to the medium through both membranes.	Nitrogen Dioxide	51-54	NBL1, DAN family BMP antagonist	Homo sapiens	171-174
24435078-5	1975	The stoichiometry of alkalinisation and NO3 (-) or NO2 (-) uptake can be quantitatively explained by assuming: 1) a counter-transport, at a ratio of 1:1, of OH(-) against NO3 (-) at the plasmalemma and of OH(-) against NO2 (-) at the chloroplast envelope, and 2) a co-transport of 1:1 of OH(-) and NH4 (+) to the medium through both membranes.	Nitrogen Dioxide	219-222	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
33946017-8	2021	Importantly, OA-NO2 diminished STAT3 phosphorylation and nuclear translocation via nitroalkylation of STAT3, which inhibited keratinocyte proliferation.	Nitrogen Dioxide	16-19	signal transducer and activator of transcription 3	Mus musculus	31-36
33946017-8	2021	Importantly, OA-NO2 diminished STAT3 phosphorylation and nuclear translocation via nitroalkylation of STAT3, which inhibited keratinocyte proliferation.	Nitrogen Dioxide	16-19	signal transducer and activator of transcription 3	Mus musculus	102-107
34047540-0	2021	Flower-like Hydroxyfluoride-Sensing Platform toward NO2 Detection.	Nitrogen Dioxide	52-55	calcium channel flower domain containing 1	Homo sapiens	0-6
34030067-9	2021	DISCUSSION: Our study provides evidence that NO2 exposure, a marker of traffic-related air pollutants, may be associated with an increased risk of breast cancer, particularly ER+/PR+ tumors.	Nitrogen Dioxide	45-48	epiregulin	Homo sapiens	175-177
33970181-2	2021	The Pt3Sn/SnS2 heterostructures show promise for selective NO2 sensing due to the favored gas adsorption and gas-solid charge transfer on Pt3Sn, combined with the optimized film conductance and formation of ohmic-type Pt3Sn/SnS2 heterointerfaces.	Nitrogen Dioxide	59-62	sodium voltage-gated channel alpha subunit 11	Homo sapiens	10-14
33970181-2	2021	The Pt3Sn/SnS2 heterostructures show promise for selective NO2 sensing due to the favored gas adsorption and gas-solid charge transfer on Pt3Sn, combined with the optimized film conductance and formation of ohmic-type Pt3Sn/SnS2 heterointerfaces.	Nitrogen Dioxide	59-62	sodium voltage-gated channel alpha subunit 11	Homo sapiens	224-228
33947005-3	2021	Ascorbic acid (AA) has a critical role in the gastric conversion of NO2- to NO following ingestion of NO3-.	Nitrogen Dioxide	68-72	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
34056495-6	2021	Increasing the NO2/NO ratio in the simulated flue gas enhanced the NO x conversion rate over ACs.	Nitrogen Dioxide	15-18	gastrin	Homo sapiens	50-53
33962646-13	2021	CONCLUSIONS: We found increases in the daily number of GP respiratory consultations and inhaler prescriptions following short-term increases in exposure to NO2, PM10 and PM2.5.	Nitrogen Dioxide	156-159	ring finger protein 130	Homo sapiens	55-57
33946464-9	2021	The results imply that rich defects formed at above a critical temperature (~500  C) may damage electrical paths of sp2 chains and thus deteriorate NO2 response.	Nitrogen Dioxide	148-151	Sp2 transcription factor	Homo sapiens	116-119
33923840-4	2021	The sensitivity of the MZT thin film was 8.64% and 34.22% for 0.25 ppm and 5 ppm of NO2 gas molecules at a working temperature of 150  C, respectively.	Nitrogen Dioxide	84-87	gastrin	Homo sapiens	88-91
33923840-5	2021	The gas sensor also exhibited high repeatability and selectivity for NO2.	Nitrogen Dioxide	69-72	gastrin	Homo sapiens	4-7
33923840-7	2021	Additionally, we observed a high sensing linearity in NO2 gas molecules.	Nitrogen Dioxide	54-57	gastrin	Homo sapiens	58-61
33453599-5	2021	Consequently, the intensity of the Raman spectra of RDX, HMX and TNT is dropped by an order of 22.5, 11.45 and 17.2 times, respectively along with the shift of the NO2 vibrational modes.	Nitrogen Dioxide	164-167	chromosome 16 open reading frame 82	Homo sapiens	65-68
33544347-7	2021	The log of the sFlt1/PLGF ratio increased with rising NO2 levels (p = 0.021 and beta = 0.206), and the log of the PLGF concentration showed a negative correlation with NO2 (p = 0.008 and beta = - 0.234).	Nitrogen Dioxide	54-57	placental growth factor	Homo sapiens	21-25
33636666-9	2021	Based on the mechanism analysis, the second-order rate constants of AAP reacts with HO , Cl ,  NH2, ClO , Cl2 - and  NO2 were calculated through transition state theory as 2.66x109 M-1 s-1, 2.61x109 M-1 s-1, 1.02x107 M-1 s-1, 7.74x106 M-1 s-1, 1.32x106 M-1 s-1, 1.48x103 M-1 s-1 respectively.	Nitrogen Dioxide	117-120	serpin family F member 2	Homo sapiens	68-71
33361555-2	2021	Herein, SnO2 nanorods/ethylenediamine-modified reduced graphene oxide (SnO2/EDA-rGO) heterojunctions with selective adsorption and electronic structure modulation were engineered for highly sensitive NO2 detection at room temperature.	Nitrogen Dioxide	200-203	ectodysplasin A	Homo sapiens	76-79
33361555-3	2021	The modified EDA groups not only enable selective adsorption to significantly enrich NO2 molecules around the interface but also a favorable modulation of SnO2/EDA-rGO electronic structure by increasing the Fermi level of rGO, through which the sensing performance of NO2 is synergistically enhanced.	Nitrogen Dioxide	85-88	ectodysplasin A	Homo sapiens	13-16
33361555-3	2021	The modified EDA groups not only enable selective adsorption to significantly enrich NO2 molecules around the interface but also a favorable modulation of SnO2/EDA-rGO electronic structure by increasing the Fermi level of rGO, through which the sensing performance of NO2 is synergistically enhanced.	Nitrogen Dioxide	268-271	ectodysplasin A	Homo sapiens	13-16
33361555-3	2021	The modified EDA groups not only enable selective adsorption to significantly enrich NO2 molecules around the interface but also a favorable modulation of SnO2/EDA-rGO electronic structure by increasing the Fermi level of rGO, through which the sensing performance of NO2 is synergistically enhanced.	Nitrogen Dioxide	268-271	ectodysplasin A	Homo sapiens	160-163
33421666-3	2021	Through calculating the activation energies and rate constants of ESIPT processes, finding that the processes are increasingly inactive when substituent group changes from -CN, -CO2Me, -Cl, -Me, -NMe2 to -NO2.	Nitrogen Dioxide	205-208	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	196-200
33421666-7	2021	It follows that the intramolecular charge transfer (ICT) degrees are increasingly enlarged as substituting from -CN, -CO2Me, -Cl, -Me, -NMe2 to -NO2 groups, which not only causes the red-shift of absorption and emission of enol and keto forms, but also affects the charge distribution of proton donor and acceptor, inhibiting the occurrence of ESIPT processes.	Nitrogen Dioxide	145-148	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	136-140
33556817-5	2021	RESULTS: A significant association between circulating PCSK9 levels and three tested air pollutants (PM10, PM2.5, nitric oxide (NO2)) was found.	Nitrogen Dioxide	128-131	proprotein convertase subtilisin/kexin type 9	Homo sapiens	55-60
33637244-2	2021	TiO2 played important roles in the emission flux density of NO2 (RNO2) and HONO (RHONO), depending on crystal structures and mass ratios of TiO2.	Nitrogen Dioxide	60-63	NLR family pyrin domain containing 12	Homo sapiens	65-69
33127147-5	2021	According to the correlation coefficients between NO3 production rates (PNO3) and NO2 or O3 levels, PNO3 was sensitive to NO2 mixing ratio at higher altitude but to O3 near the ground.	Nitrogen Dioxide	82-85	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
33739910-5	2021	The main findings are as follows: (1) the statistical model applied in this study can well evaluate the impacts of ISM; (2) the implementation of ISM can significantly reduce the concentrations of SO2, CO, and NO2, but the improvements for PM2.5, PM10, GAD and O3_8H were not significant.	Nitrogen Dioxide	210-213	isthmin 1	Homo sapiens	146-149
33569852-4	2021	Density functional theory (DFT) calculations reproduce experimental results and show that dissociation of nitrate ligands, with ejection of neutral NO2 , is favored for both [UO2 (NO3 )3 ]- and [UO2 (NO3 )2 (O2 )]- .	Nitrogen Dioxide	148-151	NBL1, DAN family BMP antagonist	Homo sapiens	180-183
33569852-4	2021	Density functional theory (DFT) calculations reproduce experimental results and show that dissociation of nitrate ligands, with ejection of neutral NO2 , is favored for both [UO2 (NO3 )3 ]- and [UO2 (NO3 )2 (O2 )]- .	Nitrogen Dioxide	148-151	NBL1, DAN family BMP antagonist	Homo sapiens	200-203
33586947-4	2021	A detailed study with in situ differential electrochemical mass spectrometry (DEMS) elucidated that NO2 could follow three reaction pathways during charging: (1) oxidation of Li2O2 to evolve oxygen, (2) vaporization, and (3) conversion into NO3-.	Nitrogen Dioxide	100-103	NBL1, DAN family BMP antagonist	Homo sapiens	241-244
33586947-6	2021	At the end of the charging process, most of the volatile oxidized couple (NO2) is stored by conversion to a stable third species (NO3-), which is then reused for producing the reduced couple (NO2-) in the next cycle.	Nitrogen Dioxide	74-77	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
33586947-6	2021	At the end of the charging process, most of the volatile oxidized couple (NO2) is stored by conversion to a stable third species (NO3-), which is then reused for producing the reduced couple (NO2-) in the next cycle.	Nitrogen Dioxide	192-196	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
33603036-6	2021	Both B cells (est = - 0.19) and CD4+ cells (est = 0.16) were associated with 1 day NO2 exposure (P <= 0.031), whereas CD4+ and CD8+ cells were associated with chronic exposure to PAH456, NOx and/or NO2 (P <= 0.038 for all).	Nitrogen Dioxide	83-86	CD4 molecule	Homo sapiens	32-35
33865111-5	2021	As a result, the optimized MoS2@SnO2-2 heterostructure presents an impressive sensitivity and selectivity for NO2 gas detection at RT.	Nitrogen Dioxide	110-113	strawberry notch homolog 1	Homo sapiens	32-35
31524076-4	2021	During the 1st and 2nd WWTs, biological heterotrophic dissimilative NO3- denitrification was confirmed by simultaneous detection of both NO2- and N2O and significant production of CO2 during the NO3- degradation.	Nitrogen Dioxide	137-141	NBL1, DAN family BMP antagonist	Homo sapiens	68-71
33749948-7	2021	However, contrary to expectations, kitchen area BC and NO2 concentrations were negatively associated with IL-1beta, a pro-inflammatory marker.	Nitrogen Dioxide	55-58	interleukin 1 alpha	Homo sapiens	106-114
31453752-6	2021	NO2- could inhibit degradation for NO2- could react with free radicals, but the reason of inhibition of degradation by HCO3- , or CO32- was its influence on pH, whereas Cl-, NO3- and H2PO4- had no influence on degradation.	Nitrogen Dioxide	0-3	NBL1, DAN family BMP antagonist	Homo sapiens	174-177
31453752-6	2021	NO2- could inhibit degradation for NO2- could react with free radicals, but the reason of inhibition of degradation by HCO3- , or CO32- was its influence on pH, whereas Cl-, NO3- and H2PO4- had no influence on degradation.	Nitrogen Dioxide	35-38	NBL1, DAN family BMP antagonist	Homo sapiens	174-177
33544347-7	2021	The log of the sFlt1/PLGF ratio increased with rising NO2 levels (p = 0.021 and beta = 0.206), and the log of the PLGF concentration showed a negative correlation with NO2 (p = 0.008 and beta = - 0.234).	Nitrogen Dioxide	168-171	placental growth factor	Homo sapiens	114-118
33544347-8	2021	NO2, an indicator of the levels of primary air pollutants, presented significant positive correlation with an increased sFlt1/PLGF ratio and diminished PLGF levels, which may reflect an antiangiogenic state generated by air pollution exposure.	Nitrogen Dioxide	0-3	placental growth factor	Homo sapiens	126-130
33544347-8	2021	NO2, an indicator of the levels of primary air pollutants, presented significant positive correlation with an increased sFlt1/PLGF ratio and diminished PLGF levels, which may reflect an antiangiogenic state generated by air pollution exposure.	Nitrogen Dioxide	0-3	placental growth factor	Homo sapiens	152-156
33472361-4	2021	Increasing pH and/or decreasing oxygen promoted the conversion of nitrate (NO3-) into NO2- but suppressed the H2O2 formation, suggesting that there was a transition of radicals from oxidizing species like hydroxyl radicals to reducing species like hydrogen atoms and hydrated electrons.	Nitrogen Dioxide	86-89	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
33280908-3	2021	The ground observations and tropospheric columns show that high NO2 concentrations are predominantly concentrated in UAs such as Beijing-Tianjin-Hebei (BTH), the Shandong Peninsula (SP), the Central Plain (CP), Central Shaanxi (CS), and the Yangtze River Delta (YRD).	Nitrogen Dioxide	64-67	citrate synthase	Homo sapiens	228-230
33369150-14	2021	Furthermore, diabetic LDLR-/- mice displayed a higher blood pressure, plasma triglycerides, cholesterol, ET-1 and NO2/NO3 levels, when compared with normoglycemic LDLR-/- and BALB mice.	Nitrogen Dioxide	114-117	low density lipoprotein receptor	Mus musculus	22-26
33170181-1	2021	An additional dimension of selectivity for the determination of RDX by ion mobility spectrometry (IMS) was introduced through field-induced decomposition of RDX Cl- to NO2- on a spectral baseline free of interfering peaks.	Nitrogen Dioxide	168-172	radixin	Homo sapiens	64-67
32882555-18	2021	In conclusion, urbanization, NO2 and traffic exhaust can increase the risk of adult asthma and AR.	Nitrogen Dioxide	29-32	ferredoxin reductase	Mus musculus	95-97
33049484-8	2021	From lag2 to lag5, high-concentration NO2 (90th percentile) was associated with increased risk of RA readmissions, with the highest RR observed at lag 4 (1.11, 95%CI: 1.05-1.17).	Nitrogen Dioxide	38-41	granulysin	Homo sapiens	5-9
33049484-8	2021	From lag2 to lag5, high-concentration NO2 (90th percentile) was associated with increased risk of RA readmissions, with the highest RR observed at lag 4 (1.11, 95%CI: 1.05-1.17).	Nitrogen Dioxide	38-41	LAG5	Homo sapiens	13-17
33226391-1	2020	This work demonstrated the development of conducting poly(chrysoidine G) (PCG)-gold nanoparticle (AuNP)-modified fluorine-doped tin oxide (F : SnO2, FTO) film-coated glass electrodes for the sensitive electrochemical detection of nitrite (NO2-).	Nitrogen Dioxide	239-243	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	149-152
32814203-6	2020	The HCHO:NO2 ratio (Rfn) was used to characterise tropospheric ozone formation conditions.	Nitrogen Dioxide	9-12	RNA exonuclease 2	Homo sapiens	20-23
32814187-5	2021	Among the AgyPd10-y/g-CxN4 catalyst, the Ag3Pd7/g-C1.95N4 catalyst exhibited the highest photocatalytic activity and selectivity for photocatalytic reduction of NO3- and NO2-, and the removal rate of NO3- and NO2- are 87.4% and 61.8% under 365 nm irradiation at 25  C, respectively.	Nitrogen Dioxide	170-173	NBL1, DAN family BMP antagonist	Homo sapiens	161-164
32814187-5	2021	Among the AgyPd10-y/g-CxN4 catalyst, the Ag3Pd7/g-C1.95N4 catalyst exhibited the highest photocatalytic activity and selectivity for photocatalytic reduction of NO3- and NO2-, and the removal rate of NO3- and NO2- are 87.4% and 61.8% under 365 nm irradiation at 25  C, respectively.	Nitrogen Dioxide	170-173	NBL1, DAN family BMP antagonist	Homo sapiens	200-203
33181478-5	2021	Herein, focus is placed on the reduction-oxidation (redox) characteristics and stability of specific NO2-FA regioisomers having biological and clinical relevance; nitro-oleic acid (NO2-OA), bis-allylic nitro-linoleic acid (NO2-LA) and the conjugated diene-containing nitro-conjugated linoleic acid (NO2-cLA).	Nitrogen Dioxide	101-104	selectin P ligand	Homo sapiens	303-306
33226391-4	2020	The as-prepared AuNP/PCG/FTO electrode exhibited excellent electrocatalytic activity for the oxidation of NO2- with high sensitivity (approximately 0.63 muA cm-2 muM-1) and a low limit of detection (0.095 muM), which is relevant within the normal concentration range of NO2- in human bodily fluids.	Nitrogen Dioxide	106-110	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	25-28
33226391-4	2020	The as-prepared AuNP/PCG/FTO electrode exhibited excellent electrocatalytic activity for the oxidation of NO2- with high sensitivity (approximately 0.63 muA cm-2 muM-1) and a low limit of detection (0.095 muM), which is relevant within the normal concentration range of NO2- in human bodily fluids.	Nitrogen Dioxide	106-110	PWWP domain containing 3A, DNA repair factor	Homo sapiens	162-167
33226391-4	2020	The as-prepared AuNP/PCG/FTO electrode exhibited excellent electrocatalytic activity for the oxidation of NO2- with high sensitivity (approximately 0.63 muA cm-2 muM-1) and a low limit of detection (0.095 muM), which is relevant within the normal concentration range of NO2- in human bodily fluids.	Nitrogen Dioxide	270-274	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	25-28
33226391-5	2020	The AuNP/PCG/FTO sensor showed sufficient reproducibility, repeatability, low interference, and strong recovery for NO2- detection in food samples.	Nitrogen Dioxide	116-119	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	13-16
32951044-2	2020	SUMMARY ANSWER: In this first real-world approach to demonstrate the relationship between air pollutants and serum AMH levels, adverse associations were observed for nitrogen dioxide (NO2) but not with particulate matter.	Nitrogen Dioxide	184-187	anti-Mullerian hormone	Homo sapiens	115-118
33316963-2	2020	Structural factors have been identified that determine the gas-phase acidity of ortho-substituted benzenesulfonic acid, 2-XC6H4-SO3H, (X = -SO3H, -COOH, -NO2, -SO2F, -C N, -NH2, -CH3, -OCH3, -N(CH3)2, -OH).	Nitrogen Dioxide	154-157	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	59-62
32931793-8	2020	Analysis of CD11b/CD11c expressing cells showed ITB-induced non-resident macrophage infiltration (4 +- 2.3 vs 43 +- 2.4%) was decreased by OA-NO2 (24 +- 2.4%).	Nitrogen Dioxide	142-145	integrin subunit alpha M	Homo sapiens	12-17
32931793-8	2020	Analysis of CD11b/CD11c expressing cells showed ITB-induced non-resident macrophage infiltration (4 +- 2.3 vs 43 +- 2.4%) was decreased by OA-NO2 (24 +- 2.4%).	Nitrogen Dioxide	142-145	integrin subunit alpha X	Homo sapiens	18-23
33140122-1	2020	PURPOSE: The pharmacokinetic properties of plasma NO3- and its reduced metabolite, NO2-, have been separately described, but there has been no reported attempt to simultaneously model their pharmacokinetics following NO3- ingestion.	Nitrogen Dioxide	83-87	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
32951044-10	2020	AMH levels were inversely related to environmental pollutants, such as PM10 (Rho = -0.088, P = 0.001), PM2.5 (Rho = -0.062, P = 0.021) and NO2 (Rho = -0.111, P < 0.001).	Nitrogen Dioxide	139-142	anti-Mullerian hormone	Homo sapiens	0-3
32951044-12	2020	On the contrary, considering NO2 quartiles, higher AMH levels were observed in third quartile compared to fourth quartile, even after adjustment for age (P = 0.028), indicating a stronger influence of NO2 exposure on AMH serum levels.	Nitrogen Dioxide	29-32	anti-Mullerian hormone	Homo sapiens	51-54
32951044-12	2020	On the contrary, considering NO2 quartiles, higher AMH levels were observed in third quartile compared to fourth quartile, even after adjustment for age (P = 0.028), indicating a stronger influence of NO2 exposure on AMH serum levels.	Nitrogen Dioxide	201-204	anti-Mullerian hormone	Homo sapiens	51-54
32951044-12	2020	On the contrary, considering NO2 quartiles, higher AMH levels were observed in third quartile compared to fourth quartile, even after adjustment for age (P = 0.028), indicating a stronger influence of NO2 exposure on AMH serum levels.	Nitrogen Dioxide	201-204	anti-Mullerian hormone	Homo sapiens	217-220
32951044-13	2020	Considering an AMH cut-off of 0.3 ng/ml, a significant higher frequency of women with severe ovarian reserve reduction in the fourth quartile was shown only for NO2 (P = 0.010).	Nitrogen Dioxide	161-164	anti-Mullerian hormone	Homo sapiens	15-18
33024169-1	2020	Recently, it was suggested that the nitrite (NO2-) produced from NO3- by oral bacteria might contribute to oral and general health.	Nitrogen Dioxide	45-49	NBL1, DAN family BMP antagonist	Homo sapiens	65-68
33035287-4	2020	It was found that the main small-molecule product of CL-20 during initial decomposition under the three different conditions was always NO2, but the generation pathways were different.	Nitrogen Dioxide	136-139	epithelial membrane protein 1	Homo sapiens	53-58
32982622-0	2021	Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review.	Nitrogen Dioxide	17-20	angiotensin converting enzyme 2	Homo sapiens	89-120
32982622-6	2021	High ACE-2 expression in respiratory epithelial cells under air pollution explains the positive correlation between the severity in COVID-19 patients and elevated air pollution, notably high NO2 and PM2.5 levels.	Nitrogen Dioxide	191-194	angiotensin converting enzyme 2	Homo sapiens	5-10
32899278-2	2020	As the calcium nitrite content increased, the generation rate and generated amount of nitrite-based hydration products also increased, owing to the rapid reaction between NO2- ions in calcium nitrite and C3A(Al2O3).	Nitrogen Dioxide	171-174	complement C3	Homo sapiens	204-207
32948795-6	2020	NO2-OA also significantly reduced RyR2-phosphorylation by inhibition of increased CaMKII activity.	Nitrogen Dioxide	0-3	ryanodine receptor 2, cardiac	Mus musculus	34-38
32403076-3	2020	Addition of NO2-group at the gamma-position of the chelate cycle causes stabilization of levels the five upper occupied molecular orbitals (MO) and destabilization of the bonding orbital pi3Ph + pi3 level.	Nitrogen Dioxide	12-15	peptidase inhibitor 3	Homo sapiens	187-190
32820387-10	2020	It can be revealed from the result that the initial reaction path of Composition B decomposition is N-NO2 of RDX cleavage to form NO2, followed by the reaction of TNT with NO2 and other molecules.	Nitrogen Dioxide	102-105	radixin	Homo sapiens	109-112
32272331-3	2020	When the generation of NO2- and NO3- ions under US exposure was investigated for N2, O2 and Ar-bubbled solutions, no trace of NO2- was observed while NO3- was slightly generated.	Nitrogen Dioxide	23-26	NBL1, DAN family BMP antagonist	Homo sapiens	150-153
32272331-3	2020	When the generation of NO2- and NO3- ions under US exposure was investigated for N2, O2 and Ar-bubbled solutions, no trace of NO2- was observed while NO3- was slightly generated.	Nitrogen Dioxide	23-27	NBL1, DAN family BMP antagonist	Homo sapiens	150-153
33201649-7	2020	Concentrations NO2 higher 30 mug/m3 affect adiponectin levels in cord blood, cholesterol metabolism, and therefore increase later the risk of overweight or obesity.	Nitrogen Dioxide	15-18	adiponectin, C1Q and collagen domain containing	Homo sapiens	43-54
32820387-10	2020	It can be revealed from the result that the initial reaction path of Composition B decomposition is N-NO2 of RDX cleavage to form NO2, followed by the reaction of TNT with NO2 and other molecules.	Nitrogen Dioxide	130-133	radixin	Homo sapiens	109-112
32746628-4	2022	An increase in NO2 level by 10 mug/m3 was related to an increase in the daily number of outpatients by 5.43% (95% confidence interval [CI]: 2.25%, 8.70%) at lag0, by 4.35% (95% CI: 1.15%, 7.66%) at lag1, and by 3.21% (95% CI: 0.05%, 6.47%) at lag3.	Nitrogen Dioxide	15-18	ceramide synthase 1	Homo sapiens	198-202
32746628-4	2022	An increase in NO2 level by 10 mug/m3 was related to an increase in the daily number of outpatients by 5.43% (95% confidence interval [CI]: 2.25%, 8.70%) at lag0, by 4.35% (95% CI: 1.15%, 7.66%) at lag1, and by 3.21% (95% CI: 0.05%, 6.47%) at lag3.	Nitrogen Dioxide	15-18	lymphocyte activating 3	Homo sapiens	243-247
32639143-9	2020	Moreover, the NO2 sensing properties of the p-SnO/n-ZnO device was investigated under various relative humidity (RH).	Nitrogen Dioxide	14-17	strawberry notch homolog 1	Homo sapiens	46-49
32412399-4	2020	The NO2 photolysis frequency was determined by measuring the rate of conversion to NO as a function of converter residence time and found to be 4.2 sec-1.	Nitrogen Dioxide	4-7	secretory blood group 1, pseudogene	Homo sapiens	148-153
32447007-9	2020	High atmospheric NO2 may provide a second hit causing a severe form of SARS-CoV-2 in ACE-2 depleted lungs resulting in a worse outcome.	Nitrogen Dioxide	17-20	angiotensin converting enzyme 2	Homo sapiens	85-90
32570333-4	2020	The monthly mean contributions of shipping emissions reached 80.72% (2.15 ppbv) and 81.79% (8.79 ppbv) to ambient SO2 and NO2 in Ningbo Port, and 10.61% (6.96 mug/m3) to PM2.5 in Shanghai Port, respectively, regions with dense ship traffic.	Nitrogen Dioxide	122-125	inositol polyphosphate-5-phosphatase D	Homo sapiens	34-38
32570333-5	2020	The relative differences in the PM2.5, SO2, and NO2 concentrations modeled using monthly and hourly ship emissions accounted for -10-15%, -10-30%, and - 5-30%, respectively.	Nitrogen Dioxide	48-51	inositol polyphosphate-5-phosphatase D	Homo sapiens	100-104
32727483-9	2020	RESULTS: Significant associations between individual industrial exposures and ACPA positivity defined by the 20 U/ml threshold were seen with single-exposure logistic regression models, for industrial emissions of PM2.5 (odds ratio, OR = 1.19, 95% confidence intervals, CI: 1.04-1.36) and SO2 (OR = 1.03, 95% CI: 1.00-1.06), without clear associations for NO2 (OR = 1.01, 95% CI: 0.86-1.17).	Nitrogen Dioxide	356-359	proteinase 3	Homo sapiens	78-82
32849729-8	2020	During hypoxia and anoxia, NO3 in the cytosol is metabolised to produce nitrite (NO2), which is reduced to form NO via the reductive pathway in the mitochondria.	Nitrogen Dioxide	81-84	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
32639143-0	2020	Growth and NO2 Sensing Properties of Biaxial p-SnO/n-ZnO Heterostructured Nanowires.	Nitrogen Dioxide	11-14	strawberry notch homolog 1	Homo sapiens	47-50
32639143-8	2020	The limit of detection of NO2 for the p-SnO/n-ZnO sensor is 50 ppb.	Nitrogen Dioxide	26-29	strawberry notch homolog 1	Homo sapiens	40-43
32639143-10	2020	Finally, the NO2 sensing mechanism of the p-SnO/n-ZnO nanowires was proposed and discussed.	Nitrogen Dioxide	13-16	strawberry notch homolog 1	Homo sapiens	44-47
32126422-0	2020	Edge-exposed MoS2 nanospheres assembled with SnS2 nanosheet to boost NO2 gas sensing at room temperature.	Nitrogen Dioxide	69-72	sodium voltage-gated channel alpha subunit 11	Homo sapiens	45-49
32671602-9	2021	Moreover, the protective effect of NO2-OA relies on the inhibition of macrophage prostaglandin E2 (PGE2)-induced PGE2 receptor 4 (EP4) cAMP signaling, known to participate in the development of AAA.	Nitrogen Dioxide	35-38	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	130-133
32336537-0	2020	rGO modified nanoplate-assembled ZnO/CdO junction for detection of NO2.	Nitrogen Dioxide	67-70	cell adhesion associated, oncogene regulated	Homo sapiens	37-40
32336537-3	2020	The sensing experimental data indicate that the highest response of the ZnO/CdO/rGO (1.0 wt%) composite to ppm-level NO2 is 8 times and 2 times higher than pure ZnO and ZnO/CdO junction, respectively.	Nitrogen Dioxide	117-120	cell adhesion associated, oncogene regulated	Homo sapiens	76-79
32336537-3	2020	The sensing experimental data indicate that the highest response of the ZnO/CdO/rGO (1.0 wt%) composite to ppm-level NO2 is 8 times and 2 times higher than pure ZnO and ZnO/CdO junction, respectively.	Nitrogen Dioxide	117-120	cell adhesion associated, oncogene regulated	Homo sapiens	173-176
32715213-3	2020	In the case of derivatives, such a transition is separated by energy, and two TPA peaks can be clearly observed (derivatives containing NO2 and NMe2 groups have two TPA peaks), where the magnitude of the separation is directly related to the intensity of the peripheral group.	Nitrogen Dioxide	136-139	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	144-148
32767485-5	2020	The ultrahigh accuracy of the 15-T FT-ICR MS was utilized to distinguish two closely spaced peaks representing the monoisotopic [M + NO2 ]- and second isotopic [M + HCOO]- ions, thereby enabling the discovery of a [M + NO2 ]- adduct ion in the ESI analysis of RDX or HMX.	Nitrogen Dioxide	133-136	radixin	Homo sapiens	260-263
32767485-5	2020	The ultrahigh accuracy of the 15-T FT-ICR MS was utilized to distinguish two closely spaced peaks representing the monoisotopic [M + NO2 ]- and second isotopic [M + HCOO]- ions, thereby enabling the discovery of a [M + NO2 ]- adduct ion in the ESI analysis of RDX or HMX.	Nitrogen Dioxide	219-222	radixin	Homo sapiens	260-263
32767485-7	2020	It is the first report explaining the discovery of [M + NO2 ]- adduct ion in the ESI-MS analyses of RDX and HMX.	Nitrogen Dioxide	56-59	radixin	Homo sapiens	100-103
32126422-6	2020	The p-n heterojunction formed between the edge-exposed spherical MoS2 and the 3D flower-like SnS2 NSs has a synergistic effect, providing a highly active sites for the adsorption of NO2 gas, which greatly enhance the sensitivity of the sensor.	Nitrogen Dioxide	182-185	sodium voltage-gated channel alpha subunit 11	Homo sapiens	93-97
32383386-0	2020	SnS2 Quantum Dots Based Optoelectronic Flexible Sensor for Ultrasensitive Detection of NO2 Down to One-ppb.	Nitrogen Dioxide	87-90	sodium voltage-gated channel alpha subunit 11	Homo sapiens	0-4
32608429-9	2020	The reaction of with NO3 should mainly produce , CO2, O2 and NO2, which might play an important role in atmospheric chemistry of peroxy radicals at night, but has less contribution to the night-time conversion of ( and RO ) to ( and HO ) in the local atmosphere.	Nitrogen Dioxide	61-64	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
32574223-1	2020	PURPOSE: Nitrate (NO3-), through its conversion to nitrite (NO2-) and nitric oxide, has been shown to increase exercise tolerance in healthy younger adults and older diseased patients.	Nitrogen Dioxide	60-64	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
32590366-0	2020	2D/2D heterojunction of g-C3N4/SnS2: room-temperature sensing material for ultrasensitive and rapid-recoverable NO2 detection.	Nitrogen Dioxide	112-115	sodium voltage-gated channel alpha subunit 11	Homo sapiens	31-35
32590366-3	2020	Herein, a 2D/2D heterojunction of g-C3N4/SnS2 is designed to improve the sensing performance of SnS2 and used for ultrasensitive and rapid-recoverable NO2 detection at room temperature.	Nitrogen Dioxide	151-154	sodium voltage-gated channel alpha subunit 11	Homo sapiens	41-45
32590366-3	2020	Herein, a 2D/2D heterojunction of g-C3N4/SnS2 is designed to improve the sensing performance of SnS2 and used for ultrasensitive and rapid-recoverable NO2 detection at room temperature.	Nitrogen Dioxide	151-154	sodium voltage-gated channel alpha subunit 11	Homo sapiens	96-100
32590366-4	2020	The pristine SnS2 fails to work at room temperature because of its properties of high resistivity and weak adsorption to NO2.	Nitrogen Dioxide	121-124	sodium voltage-gated channel alpha subunit 11	Homo sapiens	13-17
32590366-5	2020	After the combination with g-C3N4 nanosheets, the g-C3N4/SnS2-based sensor exhibits extremely high response (503%) and short recovery time (166 s) towards 1 ppm NO2 at room temperature.	Nitrogen Dioxide	161-164	sodium voltage-gated channel alpha subunit 11	Homo sapiens	57-61
32478346-4	2020	DFT calculations are consistent with two one-electron CoII reductants binding to one NO2- bridge, then proton transfer being needed for facile N/O bond scission.	Nitrogen Dioxide	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
32426961-0	2020	Enhanced NO2 sensitivity in Schottky contacted n-type SnS2 gas sensors.	Nitrogen Dioxide	9-12	sodium voltage-gated channel alpha subunit 11	Homo sapiens	54-58
32383386-3	2020	Here in, SnS2 QDs /graphene nano heterostructure as functional flexible sensors are fabricated for NO2 gas and light detection at room temperature.	Nitrogen Dioxide	99-102	sodium voltage-gated channel alpha subunit 11	Homo sapiens	9-13
32444916-7	2020	The electronic spectra of the complexes of CX[4] with NO3, NO2, CO2, and N2) exhibit a blue-shift pick in comparison with the ones observed for the CX[4] molecule.	Nitrogen Dioxide	59-62	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
32173875-5	2020	We observed that NO2 levels decreased when the cells were treated with a PGE2 receptor agonist (EP1/EP2/EP3) or COX-2 inhibitor (NS-398) and that TNF-alpha, IL-17 and IFN-gamma cytokine levels decreased when the cells were treated with a PGE2 receptor agonist (EP2) or PGE2 itself.	Nitrogen Dioxide	17-20	cytochrome c oxidase subunit II	Canis lupus familiaris	112-117
31231758-3	2020	We therefore hypothesized that dietary nitrate (NO3-), a source of NO via the NO3-   nitrite (NO2 )   NO enterosalivary pathway, could increase muscle contractile function in older subjects.	Nitrogen Dioxide	94-97	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
31231758-3	2020	We therefore hypothesized that dietary nitrate (NO3-), a source of NO via the NO3-   nitrite (NO2 )   NO enterosalivary pathway, could increase muscle contractile function in older subjects.	Nitrogen Dioxide	94-97	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
31231758-7	2020	RESULTS: NO3- ingestion increased (P&lt;0.001) plasma NO3-, plasma NO2 , and breath NO by 1051+-433%, 138+-149%, and 111+-115%, respectively.	Nitrogen Dioxide	67-70	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
32503203-5	2020	The temperature range was from 50  C to 190  C. Finally, we checked how the resistance of the samples changes when the other gases (NO2, NH3) appear in tested gas mixtures.	Nitrogen Dioxide	132-135	gastrin	Homo sapiens	125-128
31978824-5	2020	The inhibition on NAR and NIR activity and their encoding narG and nirK gene abundance further inhibited NO3- and NO2- reduction, leading to a dramatic decrease in the 15N-N2 production.	Nitrogen Dioxide	114-117	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	26-29
32391486-2	2020	Herein, an ingenious form of in situ photoenergy gas sensor integrated with a deep ultraviolet light-emitting diode (LED) has been designed to achieve ppb level NO2 gas detection at room temperature.	Nitrogen Dioxide	161-164	gastrin	Homo sapiens	49-52
32257188-11	2020	A significant positive correlation was observed between urine NO2 -+NO3 - and estimated glomerular filtration rate in patients with type 1 diabetes (P=0.002) and healthy subjects (P=0.008).	Nitrogen Dioxide	62-65	NBL1, DAN family BMP antagonist	Homo sapiens	68-71
32391486-2	2020	Herein, an ingenious form of in situ photoenergy gas sensor integrated with a deep ultraviolet light-emitting diode (LED) has been designed to achieve ppb level NO2 gas detection at room temperature.	Nitrogen Dioxide	161-164	gastrin	Homo sapiens	165-168
31922397-6	2020	The smallest fabricated gas sensor (active area = 30 x 30 mum2) showed excellent NO2 sensitivity (DeltaR/R0 = 605% to 1 ppm NO2) at the optimal operating power (~184 muW).	Nitrogen Dioxide	81-84	gastrin	Homo sapiens	24-27
32252726-10	2020	A 0.5% increase in daily admissions per 10-mug/m3 increase in the nitrogen dioxide level occurred at lag 1 and lag 2, and a 0.3% increase in daily admissions per 10-mug/m3 increase in fine particulate matter occurred at lag 1.	Nitrogen Dioxide	66-82	ceramide synthase 1	Homo sapiens	101-106
32252726-10	2020	A 0.5% increase in daily admissions per 10-mug/m3 increase in the nitrogen dioxide level occurred at lag 1 and lag 2, and a 0.3% increase in daily admissions per 10-mug/m3 increase in fine particulate matter occurred at lag 1.	Nitrogen Dioxide	66-82	granulysin	Homo sapiens	111-116
32308262-1	2020	The human ceruloplasmin (hCP) is the copper containing ferroxidase enzyme with multifunctional activities (NO-oxidase, NO2-synthase,oxidation of neurotransmitters including antioxidants).	Nitrogen Dioxide	119-122	ceruloplasmin	Homo sapiens	10-23
32084312-2	2020	In this study, a fast photochemical renoxification rate of adsorbed HNO3/NO3- to active nitrogen species (HONO, NO and NO2) was detected on real urban PM2.5, and sulfate was found to play a key role in this process.	Nitrogen Dioxide	119-122	NBL1, DAN family BMP antagonist	Homo sapiens	68-76
32184587-7	2020	NO2 was also associated with an increased risk of hospital admissions for asthma (RR=1.040, 95% CI: 1.008-1.074) and COPD (RR=1.049, 95% CI: 1.010-1.090).	Nitrogen Dioxide	0-3	COPD	Homo sapiens	117-121
32280889-8	2020	Especially, PTB visits were significantly related with PM10 and NO2 in Lag 1 and NO2 and SO2 in Lag 2.	Nitrogen Dioxide	64-67	ceramide synthase 1	Homo sapiens	71-76
32239870-17	2020	In Aim 2, effects of MOSES controlled O3 exposures on forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were modified by ambient NO2 and carbon monoxide (CO), and PES NO2, with reductions in FEV1 and FVC observed only when these concentrations were "Medium" or "High" in the 72 hours before the pre-exposure visit.	Nitrogen Dioxide	155-158	absent in melanoma 2	Homo sapiens	3-8
31922397-6	2020	The smallest fabricated gas sensor (active area = 30 x 30 mum2) showed excellent NO2 sensitivity (DeltaR/R0 = 605% to 1 ppm NO2) at the optimal operating power (~184 muW).	Nitrogen Dioxide	81-84	trafficking protein particle complex subunit 1	Homo sapiens	58-62
31922397-6	2020	The smallest fabricated gas sensor (active area = 30 x 30 mum2) showed excellent NO2 sensitivity (DeltaR/R0 = 605% to 1 ppm NO2) at the optimal operating power (~184 muW).	Nitrogen Dioxide	124-127	gastrin	Homo sapiens	24-27
31922397-6	2020	The smallest fabricated gas sensor (active area = 30 x 30 mum2) showed excellent NO2 sensitivity (DeltaR/R0 = 605% to 1 ppm NO2) at the optimal operating power (~184 muW).	Nitrogen Dioxide	124-127	trafficking protein particle complex subunit 1	Homo sapiens	58-62
31661676-0	2020	Highly sensitive NO2 gas sensors based on hexagonal SnS2 nanoplates operating at room temperature.	Nitrogen Dioxide	17-20	sodium voltage-gated channel alpha subunit 11	Homo sapiens	52-56
32203000-2	2020	MATERIALS AND METHODS: The COPD model was induced in rats by nitrogen dioxide (NO2) inhalation for 60 days.	Nitrogen Dioxide	61-77	COPD	Homo sapiens	27-31
32203000-2	2020	MATERIALS AND METHODS: The COPD model was induced in rats by nitrogen dioxide (NO2) inhalation for 60 days.	Nitrogen Dioxide	79-82	COPD	Homo sapiens	27-31
32148856-7	2020	Here we report the crystal structure of copper-bound human CAII (Cu-CAII) in complex with NO2 - at 1.2 A resolution.	Nitrogen Dioxide	90-93	carbonic anhydrase 2	Homo sapiens	59-63
32148856-7	2020	Here we report the crystal structure of copper-bound human CAII (Cu-CAII) in complex with NO2 - at 1.2 A resolution.	Nitrogen Dioxide	90-93	carbonic anhydrase 2	Homo sapiens	65-72
32148856-9	2020	The copper-substituted CAII active site is penta-coordinated with a "side-on" bound NO2 -, resembling a T-2 center.	Nitrogen Dioxide	84-87	carbonic anhydrase 2	Homo sapiens	23-27
31661676-8	2020	Our research resulted in a SnS2 nanoplate-based sensor that may pave a new way for effective NO2 detection in the future.	Nitrogen Dioxide	93-96	sodium voltage-gated channel alpha subunit 11	Homo sapiens	27-31
32117058-9	2020	In isolated islets, we have shown that galectin 3 overexpression increases cytokine and palmitate-triggered beta-cell apoptosis and also increases NO2--induced oxidative stress of beta cells.	Nitrogen Dioxide	147-150	lectin, galactose binding, soluble 3	Mus musculus	39-49
32117058-11	2020	Conclusions/Interpretation: By complementary in vivo and in vitro approaches, we have shown that galectin 3-overexpression facilitates beta-cell damage, enhances cytokine and palmitate-triggered beta-cell apoptosis, and increases NO2--induced oxidative stress in beta cells.	Nitrogen Dioxide	230-233	lectin, galactose binding, soluble 3	Mus musculus	97-107
31661676-3	2020	In this work, we present a gas sensor based on hexagonal tin disulfide (SnS2) nanoplates for sensitive and reversible NO2 sensing at room temperature.	Nitrogen Dioxide	118-121	sodium voltage-gated channel alpha subunit 11	Homo sapiens	72-76
31661676-7	2020	The sensing mechanism of this sensor could be explained as the physisorption and charge transfer between NO2 molecules and SnS2 nanoplates, which make it possible for the sensor to work at such a low operating temperature.	Nitrogen Dioxide	105-108	sodium voltage-gated channel alpha subunit 11	Homo sapiens	123-127
31445413-8	2020	It is found that PbCl2 and PbO could be transformed to Pb(NO3)2, highly dependent on the amount of NO2 and RH.	Nitrogen Dioxide	99-102	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
32425994-7	2019	Combined halogen chemistry induces complex effects on OH (ranging from -0.023 to 0.030 pptv) and HO2 (in the range of -3.7 to 0.73 pptv), significantly reduces the concentrations of NO3 (as much as 20 pptv) and O3 (as much as 10 ppbv), and decreases NO2 in highly polluted regions (as much as 1.7 ppbv); it increases NO2 (up to 0.20 ppbv) in other areas.	Nitrogen Dioxide	250-253	NBL1, DAN family BMP antagonist	Homo sapiens	182-185
32425994-7	2019	Combined halogen chemistry induces complex effects on OH (ranging from -0.023 to 0.030 pptv) and HO2 (in the range of -3.7 to 0.73 pptv), significantly reduces the concentrations of NO3 (as much as 20 pptv) and O3 (as much as 10 ppbv), and decreases NO2 in highly polluted regions (as much as 1.7 ppbv); it increases NO2 (up to 0.20 ppbv) in other areas.	Nitrogen Dioxide	317-320	NBL1, DAN family BMP antagonist	Homo sapiens	182-185
31195279-9	2019	This finding was attributed to the reoxidation of NO2- to NO3- during the treatment.	Nitrogen Dioxide	50-53	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
31418937-4	2019	Metabolism of NO3   and NO2   in blood and animal tissues forms nitric oxide (NO) which has profound physiological effects in ruminants and has been shown to increase glucose uptake and insulin secretion in rodents and humans.	Nitrogen Dioxide	24-27	insulin	Homo sapiens	186-193
31418937-5	2019	We hypothesized that absorption of small quantities of NO2   resulting from a low-risk dose of dietary NO3   will increase insulin sensitivity (SI ) and glucose uptake in sheep.	Nitrogen Dioxide	55-58	LOC105613195	Ovis aries	123-130
30806950-4	2019	Traffic-related air pollutants or TRAP refers to a broad group of pollutants including elemental carbon, black soot, nitrogen dioxide (NO2), nitric oxide (NO), sulfur dioxide (SO2), particulate matter (PM2.5 and PM10), carbon monoxide (CO), and carbon dioxide (CO2).	Nitrogen Dioxide	135-138	TRAP	Homo sapiens	34-38
31336304-0	2019	The coupling interaction of NO2- with NH4+ or NO3- as an important source of N2O emission from agricultural soil in the North China Plain.	Nitrogen Dioxide	28-31	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
31336304-4	2019	The results showed that the N2O average fluxes from the complex treatments of NO2- + NO3- were 1.4-2.4 times the sum of those from the separate treatments of NO2- and NO3- whereas from the complex treatments of NO2- + NH4+ were a factor of 1-1.4 larger than those from the separate treatments of NO2- and NH4+, indicating the coupling interaction of NO2- with NH4+ or NO3- makes a remarkable contribution to N2O emission from the soil.	Nitrogen Dioxide	78-81	NBL1, DAN family BMP antagonist	Homo sapiens	85-88
31336304-6	2019	As the intermediate product of nitrification and denitrification, NO2- produced is also expected to interact with NH4+ or NO3- to promote N2O emission from the soil, especially during fertilization events when NO2- is easily accumulated due to the acceleration of the nitrification and denitrification processes.	Nitrogen Dioxide	66-69	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
31336304-6	2019	As the intermediate product of nitrification and denitrification, NO2- produced is also expected to interact with NH4+ or NO3- to promote N2O emission from the soil, especially during fertilization events when NO2- is easily accumulated due to the acceleration of the nitrification and denitrification processes.	Nitrogen Dioxide	210-213	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
31541562-6	2019	ABSTRACT: Dietary nitrate (NO3 - ) supplementation, which increases plasma nitrite (NO2 - ) concentration, has been reported to attenuate skeletal muscle fatigue development.	Nitrogen Dioxide	84-87	NBL1, DAN family BMP antagonist	Mus musculus	27-30
31220783-5	2019	In maternal peripheral blood, the SOD2 promoter methylation levels were positively associated with the exposure concentrations of PM10 (during the entire pregnancy and the second trimester) and nitrogen dioxide (NO2) (during the first trimester of pregnancy), whereas the levels were negatively associated with the exposure concentrations of NO2 during the third trimester of pregnancy.	Nitrogen Dioxide	194-210	superoxide dismutase 2	Homo sapiens	34-38
31220783-5	2019	In maternal peripheral blood, the SOD2 promoter methylation levels were positively associated with the exposure concentrations of PM10 (during the entire pregnancy and the second trimester) and nitrogen dioxide (NO2) (during the first trimester of pregnancy), whereas the levels were negatively associated with the exposure concentrations of NO2 during the third trimester of pregnancy.	Nitrogen Dioxide	212-215	superoxide dismutase 2	Homo sapiens	34-38
31220783-5	2019	In maternal peripheral blood, the SOD2 promoter methylation levels were positively associated with the exposure concentrations of PM10 (during the entire pregnancy and the second trimester) and nitrogen dioxide (NO2) (during the first trimester of pregnancy), whereas the levels were negatively associated with the exposure concentrations of NO2 during the third trimester of pregnancy.	Nitrogen Dioxide	342-345	superoxide dismutase 2	Homo sapiens	34-38
31400563-8	2019	In response to a 10-ppb increase in NO2 exposure, NOS2A methylation (%5 mC) decreased 0.19 at lag 0 d, ARG2 methylation (%5 mC) increased 0.21 and FeNO levels increased 2.82% at lag 1 d; and at lag 2 d the percentage of forced vital capacity, forced expiratory volume in 1 s and peak expiratory flow in predicted values decreased 0.12, 0.37 and 0.67, respectively.	Nitrogen Dioxide	36-39	nitric oxide synthase 2	Homo sapiens	50-55
31400563-8	2019	In response to a 10-ppb increase in NO2 exposure, NOS2A methylation (%5 mC) decreased 0.19 at lag 0 d, ARG2 methylation (%5 mC) increased 0.21 and FeNO levels increased 2.82% at lag 1 d; and at lag 2 d the percentage of forced vital capacity, forced expiratory volume in 1 s and peak expiratory flow in predicted values decreased 0.12, 0.37 and 0.67, respectively.	Nitrogen Dioxide	36-39	arginase 2	Homo sapiens	103-107
31400563-11	2019	CONCLUSIONS: Our study suggests that short-term personal exposure to NO2 is associated with NOS2A hypomethylation, ARG2 hypermethylation, respiratory inflammation and lung function impairment.	Nitrogen Dioxide	69-72	nitric oxide synthase 2	Homo sapiens	92-97
30789752-5	2019	We found a negative association between NO2 exposure and CC16 levels, with a 4.7% (95% confidence interval, -8.6 to -0.7) decrease in CC16 levels from age 6 to 32 per interquartile range increase in NO2 exposure (6.0 ppb) at the participants" birth address.	Nitrogen Dioxide	40-43	secretoglobin family 1A member 1	Homo sapiens	57-61
31400563-11	2019	CONCLUSIONS: Our study suggests that short-term personal exposure to NO2 is associated with NOS2A hypomethylation, ARG2 hypermethylation, respiratory inflammation and lung function impairment.	Nitrogen Dioxide	69-72	arginase 2	Homo sapiens	115-119
31295558-16	2019	A small significant negative correlation was found between changes in salivary sialin and salivary NO2- concentrations (r = -0.20, P = 0.04).	Nitrogen Dioxide	99-103	solute carrier family 17 member 5	Homo sapiens	79-85
31129334-5	2019	During the nitrate reduction by Zn-Ag/hv/HCOOH process, rapid reduction of NO3- to NO2- was primarily caused by ZnAg bimetal.	Nitrogen Dioxide	83-86	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
30789752-0	2019	CC16 Levels into Adult Life Are Associated with Nitrogen Dioxide Exposure at Birth.	Nitrogen Dioxide	48-64	secretoglobin family 1A member 1	Homo sapiens	0-4
30789752-4	2019	Linear mixed models were used to determine the association between estimated ambient NO2 exposure at participants" home address at birth or age 6 with CC16 levels from age 6 to 32.Measurements and Main Results: NO2 exposures at birth or age 6 were available for 777 children with one or more CC16 measurement.	Nitrogen Dioxide	85-88	secretoglobin family 1A member 1	Homo sapiens	151-155
30789752-5	2019	We found a negative association between NO2 exposure and CC16 levels, with a 4.7% (95% confidence interval, -8.6 to -0.7) decrease in CC16 levels from age 6 to 32 per interquartile range increase in NO2 exposure (6.0 ppb) at the participants" birth address.	Nitrogen Dioxide	40-43	secretoglobin family 1A member 1	Homo sapiens	134-138
30789752-5	2019	We found a negative association between NO2 exposure and CC16 levels, with a 4.7% (95% confidence interval, -8.6 to -0.7) decrease in CC16 levels from age 6 to 32 per interquartile range increase in NO2 exposure (6.0 ppb) at the participants" birth address.	Nitrogen Dioxide	199-202	secretoglobin family 1A member 1	Homo sapiens	57-61
30789752-5	2019	We found a negative association between NO2 exposure and CC16 levels, with a 4.7% (95% confidence interval, -8.6 to -0.7) decrease in CC16 levels from age 6 to 32 per interquartile range increase in NO2 exposure (6.0 ppb) at the participants" birth address.	Nitrogen Dioxide	199-202	secretoglobin family 1A member 1	Homo sapiens	134-138
30789752-7	2019	NO2 at participant"s age 6 address was not significantly associated with CC16 levels (-1.9%; 95% confidence interval, -6.3 to 2.6).Conclusions: Higher exposure to NO2 at birth is associated with persistently low levels of CC16 from 6 to 32 years.	Nitrogen Dioxide	163-166	secretoglobin family 1A member 1	Homo sapiens	222-226
31173640-6	2019	These responses were greater with increases in NO or NO2- levels in NiRr plants than in the WT under NO3- nutrition.	Nitrogen Dioxide	53-56	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	68-72
31200347-4	2019	50% of NH4+ oxidized to NO2- with &lt;5% NO3-accumulation.	Nitrogen Dioxide	24-27	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
31199928-0	2019	NO2 functionalized coumarin derivatives suppress cancer progression and facilitate apoptotic cell death in KRAS mutant colon cancer.	Nitrogen Dioxide	0-3	KRAS proto-oncogene, GTPase	Homo sapiens	107-111
31372615-1	2019	The reaction of the simplest Criegee intermediate CH2OO with NO2 is considered to be important in atmospheric chemistry because of its prospective contribution to the decay of CH2OO and the additional source of NO3, hence its effects on the NOx and HOx cycles.	Nitrogen Dioxide	61-64	NBL1, DAN family BMP antagonist	Homo sapiens	211-214
31125941-0	2019	Enhancement of CO and NO2 sensing in n-SnO2-p-Cu2O core-shell nanofibers by shell optimization.	Nitrogen Dioxide	22-25	strawberry notch homolog 2	Homo sapiens	39-42
31304734-3	2019	From the surface chemical analysis, it is found that NO2 stably reconstructs surface chemical bonding with NO3- ions by capturing the charged electrons and oxygen and the regions with and without NO2 treatment display extreme differences in their electrical conductivity.	Nitrogen Dioxide	53-56	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
30982513-6	2019	Linear calibration graphs are obtained within 0.02-2, 0.1-20, 0.2-1 mg L-1 for NO2-, NO3- and NH4+, along with detection limits of 0.006, 0.03, 0.06 mg L-1, respectively.	Nitrogen Dioxide	79-82	L1 cell adhesion molecule	Homo sapiens	71-74
31304734-3	2019	From the surface chemical analysis, it is found that NO2 stably reconstructs surface chemical bonding with NO3- ions by capturing the charged electrons and oxygen and the regions with and without NO2 treatment display extreme differences in their electrical conductivity.	Nitrogen Dioxide	196-199	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
31192336-1	2019	The unique features of SnS2 make it a sensitive material ideal for preparing high-performance nitrogen dioxide (NO2) gas sensors.	Nitrogen Dioxide	94-110	sodium voltage-gated channel alpha subunit 11	Homo sapiens	23-27
31192336-1	2019	The unique features of SnS2 make it a sensitive material ideal for preparing high-performance nitrogen dioxide (NO2) gas sensors.	Nitrogen Dioxide	112-115	sodium voltage-gated channel alpha subunit 11	Homo sapiens	23-27
31192336-3	2019	Herein, an ultrasensitive and fully recoverable room-temperature NO2 gas sensor based on SnS2/SnS p-n heterojunctions with an accumulation layer was fabricated.	Nitrogen Dioxide	65-68	sodium voltage-gated channel alpha subunit 11	Homo sapiens	89-93
31192336-7	2019	The sensing response of optimized SnS2/SnS toward 4 ppm NO2 was 660% at room temperature, which was higher than most reported sensitivity values of other two-dimensional (2D) materials at room temperature.	Nitrogen Dioxide	56-59	sodium voltage-gated channel alpha subunit 11	Homo sapiens	34-38
31051259-1	2019	Nitrate (NO3-) contained in food and beverages can transiently increase nitric oxide (NO) availability following a stepwise reduction to nitrite (NO2-) by commensal bacteria in the oral cavity.	Nitrogen Dioxide	146-150	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
31051259-2	2019	We tested the hypothesis that regular ingestion of dietary NO3- would influence the oral microbiome, the capacity to reduce NO3- to NO2- in saliva, and the vascular responses to an acute dose of NO3-.	Nitrogen Dioxide	132-136	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
31051259-4	2019	As expected, saliva and plasma NO2- and NO3- were significantly elevated after NO3- supplementation (all P < 0.05) but not placebo.	Nitrogen Dioxide	31-34	NBL1, DAN family BMP antagonist	Homo sapiens	79-82
31051259-6	2019	Despite these alterations to the oral microbiota, an acute dose of NO3- increased salivary and plasma NO2-, reduced systolic blood pressure and increased the response to flow mediated dilation to a similar extent before and after 7 days of supplementation (P > 0.05).	Nitrogen Dioxide	102-106	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
31087308-2	2019	Patients with X-linked agammaglobulinemia due to hereditary Btk deficiency do not show bleeding, but a mild bleeding tendency is observed in high dose therapy of B-cell malignancies with ibrutinib and novel second-generation irreversible Btk inhibitors (acalabrutinib and ONO/GS-4059).	Nitrogen Dioxide	272-275	Bruton tyrosine kinase	Homo sapiens	60-63
31035082-0	2019	Spatial variation in the association between NO2 concentrations and shipping emissions in the Red Sea.	Nitrogen Dioxide	45-48	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	98-101
31035082-3	2019	This paper aims to characterize and quantify the contribution of maritime transport sector emissions to NO2 concentrations in the Red Sea using local Geographically Weighted Regression (GWR) model in a geographic information system (GIS) environment.	Nitrogen Dioxide	104-107	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	134-137
31035082-9	2019	Maritime traffic volume and proximity to seaports weighted by shipping activities explained about 94% of the variations of NO2 concentrations in the Red Sea.	Nitrogen Dioxide	123-126	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	153-156
31251057-5	2019	Subsequently, monodentate NO3- species decompose to NO2 to restore one of the lattice oxygen atoms that act as a reversible redox center, and the vacancy can easily activate O2 to replenish the consumed one.	Nitrogen Dioxide	52-55	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
31261612-4	2019	NO2 was positively associated with systolic and diastolic blood pressure (SBP and DBP), and inversely associated with the central retinal venular equivalent (CRVE) and mean baseline brachial artery diameter.	Nitrogen Dioxide	0-3	selenium binding protein 1	Homo sapiens	74-77
31262027-7	2019	9Tyr of PsbO1 was exclusively nitrated after incubation of the thylakoid membranes with a buffer containing NO2 and NO2- or a buffer containing NO2- alone.	Nitrogen Dioxide	108-111	PS II oxygen-evolving complex 1	Arabidopsis thaliana	8-13
31262027-7	2019	9Tyr of PsbO1 was exclusively nitrated after incubation of the thylakoid membranes with a buffer containing NO2 and NO2- or a buffer containing NO2- alone.	Nitrogen Dioxide	116-119	PS II oxygen-evolving complex 1	Arabidopsis thaliana	8-13
31262027-7	2019	9Tyr of PsbO1 was exclusively nitrated after incubation of the thylakoid membranes with a buffer containing NO2 and NO2- or a buffer containing NO2- alone.	Nitrogen Dioxide	116-119	PS II oxygen-evolving complex 1	Arabidopsis thaliana	8-13
31262027-11	2019	We hypothesized that atmospheric NO2 at ambient concentrations may induce tyrosine nitration of PYR/PYL/RCAR receptors in Arabidopsis leaves, followed by degradation of PYR/PYL/RCAR, upregulation of target of rapamycin (TOR) regulatory complexes, and stimulation of plant growth.	Nitrogen Dioxide	33-36	target of rapamycin	Arabidopsis thaliana	199-218
31262027-11	2019	We hypothesized that atmospheric NO2 at ambient concentrations may induce tyrosine nitration of PYR/PYL/RCAR receptors in Arabidopsis leaves, followed by degradation of PYR/PYL/RCAR, upregulation of target of rapamycin (TOR) regulatory complexes, and stimulation of plant growth.	Nitrogen Dioxide	33-36	target of rapamycin	Arabidopsis thaliana	220-223
31261612-4	2019	NO2 was positively associated with systolic and diastolic blood pressure (SBP and DBP), and inversely associated with the central retinal venular equivalent (CRVE) and mean baseline brachial artery diameter.	Nitrogen Dioxide	0-3	D-box binding PAR bZIP transcription factor	Homo sapiens	82-85
31028280-5	2019	RESULTS: Two SNPs near the EPHA3 (rs13090972 and rs958144) and one in TXNDC8 (rs7041938) showed significant interactions with NO2 in Caucasians but we did not replicate this locus in African-Americans.	Nitrogen Dioxide	126-129	EPH receptor A3	Homo sapiens	27-32
31316715-4	2019	We apply molecular dynamics simulations to investigate the permeation of both hydrophilic (H2O2 and OH) and hydrophobic (NO2 and NO) RONS through AQP1.	Nitrogen Dioxide	121-124	aquaporin 1 (Colton blood group)	Homo sapiens	146-150
31316715-6	2019	The permeation free energy barrier of OH and NO is lower than that of H2O2 and NO2, indicating that these radicals may have easier access to the pore interior and interact with the amino acid residues of AQP1.	Nitrogen Dioxide	79-82	aquaporin 1 (Colton blood group)	Homo sapiens	204-208
31084027-5	2019	This unprecedented interfacial charging-decharging scheme alters the peroxide-associated NO oxidation selectivity from NO2 to NO3- with a high efficiency and thus hold great promise for the treatment of risky NO x species in indoor air.	Nitrogen Dioxide	119-122	NBL1, DAN family BMP antagonist	Homo sapiens	126-129
31028280-5	2019	RESULTS: Two SNPs near the EPHA3 (rs13090972 and rs958144) and one in TXNDC8 (rs7041938) showed significant interactions with NO2 in Caucasians but we did not replicate this locus in African-Americans.	Nitrogen Dioxide	126-129	thioredoxin domain containing 8	Homo sapiens	70-76
30768269-4	2019	The early response of CL-20/TNT to thermal stimulus is dominated by N-NO2 bond cleavage for NO2 formation and C-N bond scission leading to ring-opening of CL-20.	Nitrogen Dioxide	70-73	epithelial membrane protein 1	Homo sapiens	22-27
31170679-2	2019	Herein, we evaluate the redox behavior of nitro-oleic acid (NO2-OA) and its ability to bind to the fatty acid transporter human serum albumin (HSA).	Nitrogen Dioxide	60-63	albumin	Homo sapiens	128-141
30768269-5	2019	The kinetics of N-NO2 and C-N bond cleavage, as well as the following oxygen-abstraction of NO2, are significantly slowed in the CL-20/TNT thermolysis against beta-CL-20, which are responsible for the low sensitivity at the stage of active intermediate generation.	Nitrogen Dioxide	18-21	epithelial membrane protein 1	Homo sapiens	129-134
30768269-5	2019	The kinetics of N-NO2 and C-N bond cleavage, as well as the following oxygen-abstraction of NO2, are significantly slowed in the CL-20/TNT thermolysis against beta-CL-20, which are responsible for the low sensitivity at the stage of active intermediate generation.	Nitrogen Dioxide	18-21	epithelial membrane protein 1	Homo sapiens	164-169
30768269-6	2019	The early formed active intermediates of NO2, NO3, NO, and N2O are confined and consumed by the reactions of the surrounding TNT or ring intermediates from TNT conversion, accounting for over 40% reactions of NO2 consumption.	Nitrogen Dioxide	209-212	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
30977497-4	2019	The major difference is the degree to which the major gas-phase product, NO2-, is converted to NO3-.	Nitrogen Dioxide	73-76	NBL1, DAN family BMP antagonist	Homo sapiens	95-98
30900872-5	2019	Based on these findings, a ratiometric fluorescent-based portable agarose hydrogel test kit was fabricated and applied for on-spot assessment of NO2- content within 10 min.	Nitrogen Dioxide	145-149	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	88-91
31050898-5	2019	Herein, we report the design and synthesis of ligands targeting the allosteric binding site on the CB1 cannabinoid receptor, in which a CF3 group successfully replaced the aliphatic NO2.	Nitrogen Dioxide	182-185	cannabinoid receptor 1 (brain)	Mus musculus	99-102
31050898-5	2019	Herein, we report the design and synthesis of ligands targeting the allosteric binding site on the CB1 cannabinoid receptor, in which a CF3 group successfully replaced the aliphatic NO2.	Nitrogen Dioxide	182-185	coagulation factor III	Mus musculus	136-139
31050898-6	2019	In general, the CF3-bearing compounds were more potent than their NO2 equivalents and also showed improved in vitro metabolic stability.	Nitrogen Dioxide	66-69	coagulation factor III	Mus musculus	16-19
30149947-8	2019	RESULTS: The number of hospitalisations was associated with low temperature (lags 0 to 4) and higher levels of NO2 (lags 0, 1, 2 and 4) and atmospheric pressure (lags 2 and 3).	Nitrogen Dioxide	111-114	ceramide synthase 1	Homo sapiens	116-134
31112557-1	2019	Nitrification, the microbial oxidation of ammonia (NH3) to nitrite (NO2-) and NO2- to nitrate (NO3-), plays a vital role in ocean nitrogen cycling.	Nitrogen Dioxide	78-81	NBL1, DAN family BMP antagonist	Homo sapiens	95-98
30995040-3	2019	Based on the indications from computational and experimental results, the cleavage of the strained fragment from CL-20 was identified instead of NO2 or HONO elimination as in conventional high energy materials.	Nitrogen Dioxide	145-148	epithelial membrane protein 1	Homo sapiens	113-118
31070457-9	2019	While evidence for epigenetic regulation remains limited, polycyclic aromatic hydrocarbons (PAH) and nitrogen dioxide (NO2) exposures may alter methylation of breast tumorigenic genes (e.g., EPHB2, LONP1).	Nitrogen Dioxide	119-122	EPH receptor B2	Homo sapiens	191-196
31070457-9	2019	While evidence for epigenetic regulation remains limited, polycyclic aromatic hydrocarbons (PAH) and nitrogen dioxide (NO2) exposures may alter methylation of breast tumorigenic genes (e.g., EPHB2, LONP1).	Nitrogen Dioxide	119-122	lon peptidase 1, mitochondrial	Homo sapiens	198-203
30925049-5	2019	[Nd(NO3)3(H2O)(dppz-R)] with R = H, NO2-, CN- and their [Nd(NO3)3(H2O)(dpq)] analogue, which was computationally modeled.	Nitrogen Dioxide	36-39	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
30848880-7	2019	Furthermore, because the Fermi level of the SnO2{221} facet is higher than that of graphene, the electrons are transferred from SnO2 nanoparticles to graphene sheets, enabling effective electron exchange between the composite and external NO2 gas.	Nitrogen Dioxide	239-242	strawberry notch homolog 2	Homo sapiens	44-47
30601680-6	2019	EP receptor knockdown and subtype-selective antagonists demonstrated EP2 and EP4 receptor responsiveness in HASM cells to the specific ONO compounds, whereas PGE2 appeared to preferentially signal via the EP4 receptor.	Nitrogen Dioxide	135-138	prostaglandin E receptor 4	Homo sapiens	77-80
30739207-3	2019	The average levels of NO3- and NO2- in treated wastewater samples varied from 167.2 to 209.9 mg/l for NO3- and from 80.3 to 106.1 mug/l for NO2-.	Nitrogen Dioxide	31-34	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
30934982-6	2019	The presence of NO2-OA and NO2-cLA in olives and extra-virgin olive oil and nitro-linolenic acid (NO2-Ln) in Arabidopsis thaliana has recently been detected.	Nitrogen Dioxide	27-30	selectin P ligand	Homo sapiens	31-34
30799610-3	2019	Herein, we report superior gas sensing properties of SnS2 nanograins on SiO2 nanorods toward NO2 at room temperature.	Nitrogen Dioxide	93-96	sodium voltage-gated channel alpha subunit 11	Homo sapiens	53-57
30799610-4	2019	The gas response is as high as 701% for 10 ppm of NO2 with excellent recovery characteristics and the theoretical detection limit is evaluated to be 408.9 ppb at room temperature, which has not been reported for SnS2-based gas sensors to the best of our knowledge.	Nitrogen Dioxide	50-53	sodium voltage-gated channel alpha subunit 11	Homo sapiens	212-216
30893301-10	2019	For CRP, we found significant increases in NO2 at lag1-3 days after-Asian game period and significant increases in PM10 at lag1-2 days.	Nitrogen Dioxide	43-46	C-reactive protein	Homo sapiens	4-7
30508798-5	2019	As a proposed mechanism, NO3- is initially reduced to NO2- by Cu0, and then further reduced to N2/NH4+ by Mg0.	Nitrogen Dioxide	54-57	NBL1, DAN family BMP antagonist	Homo sapiens	25-28
30747176-1	2019	Using first principles density functional theory, we have studied the interaction mechanism of NO2 and SO2 gas molecules on an MoB2 monolayer, for gas sensing applications.	Nitrogen Dioxide	95-98	MOB kinase activator 2	Homo sapiens	127-131
30747176-6	2019	The chemisorptive nature for NO2, in contrast with the relatively weaker physisorption for SO2, additionally supports the fact that NO2 gas has a better perspective for MoB2 sensor application.	Nitrogen Dioxide	29-32	MOB kinase activator 2	Homo sapiens	169-173
30747176-6	2019	The chemisorptive nature for NO2, in contrast with the relatively weaker physisorption for SO2, additionally supports the fact that NO2 gas has a better perspective for MoB2 sensor application.	Nitrogen Dioxide	132-135	MOB kinase activator 2	Homo sapiens	169-173
30747176-8	2019	The faster recovery time attributes the MoB2 monolayer better as a sensor material for NO2 interaction.	Nitrogen Dioxide	87-90	MOB kinase activator 2	Homo sapiens	40-44
30324533-5	2019	Therefore, we proposed that studying the protection mechanism of SA against the heme/H2O2/NO2--induced cytotoxicity may be more consistent with free heme-associated disorder pathologies.	Nitrogen Dioxide	90-93	albumin	Homo sapiens	65-67
30799610-0	2019	SnS2 Nanograins on Porous SiO2 Nanorods Template for Highly Sensitive NO2 Sensor at Room Temperature with Excellent Recovery.	Nitrogen Dioxide	70-73	sodium voltage-gated channel alpha subunit 11	Homo sapiens	0-4
30753054-4	2019	The response of MoS2/PbS gas sensor is about 50 times higher than that of MoS2 gas sensor at 100 ppm NO2 concentration.	Nitrogen Dioxide	101-104	cholinergic receptor muscarinic 3	Homo sapiens	21-24
30753054-6	2019	The enhanced gas-sensing properties of MoS2/PbS, which are superior to those of pure MoS2, are ascribed to the large surface area of MoS2 combined with the high responsivity of PbS quantum dots for NO2.	Nitrogen Dioxide	198-201	cholinergic receptor muscarinic 3	Homo sapiens	44-47
30753054-6	2019	The enhanced gas-sensing properties of MoS2/PbS, which are superior to those of pure MoS2, are ascribed to the large surface area of MoS2 combined with the high responsivity of PbS quantum dots for NO2.	Nitrogen Dioxide	198-201	cholinergic receptor muscarinic 3	Homo sapiens	177-180
30530107-4	2019	We show that compounds containing Cl and NO2 groups at the para position of the phenyl ring, namely compounds 7c (IC50 = 8.55 +- 3.37 microM) and 7d (IC50 = 11.42 +- 2.01 microM), possess promising BACE1 inhibitory potential.	Nitrogen Dioxide	41-44	beta-secretase 1	Rattus norvegicus	198-203
30739207-3	2019	The average levels of NO3- and NO2- in treated wastewater samples varied from 167.2 to 209.9 mg/l for NO3- and from 80.3 to 106.1 mug/l for NO2-.	Nitrogen Dioxide	140-143	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
30605314-5	2019	Resulting NO3- 18O/16O ratios showed (1) a disproportionate sensitivity to the 18O/16O ratio of water, mediated by isotopic equilibration between water and NO2-, as well as (2) kinetic isotope discrimination during O atom incorporation from molecular oxygen and water.	Nitrogen Dioxide	156-159	NBL1, DAN family BMP antagonist	Homo sapiens	10-13
30478172-10	2019	In conclusion, RAD51 Cys-319 is a functionally significant site for adduction of soft electrophiles such as OA-NO2 and suggests further investigation of lipid electrophile-based combinational therapies for TNBC.	Nitrogen Dioxide	111-114	RAD51 recombinase	Homo sapiens	15-20
30388689-9	2019	The conclusion was the energetic electrons generated in the DBD reactor played a key role on the removal of MSH, and the major decomposition products of MSH were detected as CH3SSCH3, SO2 and NO2.	Nitrogen Dioxide	192-195	msh homeobox 2	Homo sapiens	153-156
30525435-0	2019	CdTe Quantum Dot-Functionalized P25 Titania Composite with Enhanced Photocatalytic NO2 Storage Selectivity under UV and Vis Irradiation.	Nitrogen Dioxide	83-86	tubulin polymerization promoting protein	Homo sapiens	32-35
30525435-3	2019	Therefore, P25 could efficiently photooxidize NO(g) + O2(g) into NO2; however, it failed to store photogenerated NO2 and released toxic NO2(g) to the atmosphere.	Nitrogen Dioxide	65-68	tubulin polymerization promoting protein	Homo sapiens	11-14
30743827-3	2018	The results showed the pattern of ionic dominance based on mean value was following as: Cl- &gt; Na+ &gt; SO42- &gt; Ca2+ &gt; Mg2+ &gt; K+ &gt; NO3- &gt; NO2- &gt; NH4+ &gt; F- &gt; Li+.	Nitrogen Dioxide	155-158	NBL1, DAN family BMP antagonist	Homo sapiens	145-148
30562016-4	2019	Herein, NHC is found as a unique and powerful organocatalyst to construct homoatomic C-C cross-coupling, heteroatomic O-C bond formation, and cascade cyclization utilizing NO2 as a leaving group at ambient temperature.	Nitrogen Dioxide	172-175	high mobility group nucleosomal binding domain 4	Homo sapiens	8-11
31140173-10	2019	Together, current data indicate that AA is an important activator of NOX2 formed in the early events of the inflammatory response, leading to a massive production of oxidants that may, in turn, promote NO2-AA formation and shutting down the oxidative burst.	Nitrogen Dioxide	202-205	cytochrome b-245 beta chain	Homo sapiens	69-73
31140178-9	2019	Moreover, NO2-OA-modified alpha-syn showed a reduced capacity to induce alpha-syn fibrillization compared to the non-nitrated oleic acid.	Nitrogen Dioxide	10-13	synuclein alpha	Homo sapiens	26-35
31140178-9	2019	Moreover, NO2-OA-modified alpha-syn showed a reduced capacity to induce alpha-syn fibrillization compared to the non-nitrated oleic acid.	Nitrogen Dioxide	10-13	synuclein alpha	Homo sapiens	72-81
31140178-10	2019	From this data we hypothesize that nitroalkenes, in particular NO2-OA, may inhibit alpha-syn fibril formation exerting protective actions in Parkinson"s disease.	Nitrogen Dioxide	63-66	synuclein alpha	Homo sapiens	83-92
30009367-6	2019	RESULTS: Prophylactic losartan and NO2-OA were associated with improvement in SBP, serum glucose, urea, GFR, UAE, with reduction in serum Ang II and PTHrP overexpression observed in diabetic kidney.	Nitrogen Dioxide	35-38	angiotensinogen	Rattus norvegicus	138-144
30009367-6	2019	RESULTS: Prophylactic losartan and NO2-OA were associated with improvement in SBP, serum glucose, urea, GFR, UAE, with reduction in serum Ang II and PTHrP overexpression observed in diabetic kidney.	Nitrogen Dioxide	35-38	parathyroid hormone-like hormone	Rattus norvegicus	149-154
30388370-5	2018	Using quantum chemical calculations at the MP2/6-31++g(d,p) level, NO2  is shown capable of abstracting a hydrogen atom from the phenolic group on the aromatic ring.	Nitrogen Dioxide	67-70	tryptase pseudogene 1	Homo sapiens	43-46
30884482-5	2019	FABP5-deficient mouse bone marrow-derived macrophages produced higher levels of nitrite anion than their WT counterparts in response to various stimuli.	Nitrogen Dioxide	80-93	fatty acid binding protein 5, epidermal	Mus musculus	0-5
30059917-9	2019	Aerosol water content and particulate acidity were found to be positively associated with secondary SO42-, while NO2 and RH had a significant impact on secondary NO3- in an arid atmosphere.	Nitrogen Dioxide	113-116	NBL1, DAN family BMP antagonist	Homo sapiens	162-165
30193235-8	2018	Results showed that prenatal exposure to NO2 was associated with higher H19 methylation in cord blood.	Nitrogen Dioxide	41-44	H19 imprinted maternally expressed transcript	Homo sapiens	72-75
29685359-8	2018	Among air pollutant concentrations, O3 in lag-1 (p = 0.017) and lag-2 (p = 0.038), NO2 in lag-1 (p = 0.015) and lag-2 (p = 0.009), PM10 in lag-1 (p = 0.012), and PM2.5 in lag-1 (p = 0.021) and lag-2 (p = 0.032) were significantly different between no PSP and PSP days.	Nitrogen Dioxide	83-86	ceramide synthase 1	Homo sapiens	90-95
29685359-8	2018	Among air pollutant concentrations, O3 in lag-1 (p = 0.017) and lag-2 (p = 0.038), NO2 in lag-1 (p = 0.015) and lag-2 (p = 0.009), PM10 in lag-1 (p = 0.012), and PM2.5 in lag-1 (p = 0.021) and lag-2 (p = 0.032) were significantly different between no PSP and PSP days.	Nitrogen Dioxide	83-86	ceramide synthase 1	Homo sapiens	90-95
29685359-8	2018	Among air pollutant concentrations, O3 in lag-1 (p = 0.017) and lag-2 (p = 0.038), NO2 in lag-1 (p = 0.015) and lag-2 (p = 0.009), PM10 in lag-1 (p = 0.012), and PM2.5 in lag-1 (p = 0.021) and lag-2 (p = 0.032) were significantly different between no PSP and PSP days.	Nitrogen Dioxide	83-86	ceramide synthase 1	Homo sapiens	90-95
30332316-4	2018	Mice were subjected to NTS and treated with the EP4 antagonist ONO AE3-208 (10 mg kg body wt-1 day-1] or vehicle starting from disease initiation.	Nitrogen Dioxide	63-66	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	48-51
30086949-5	2018	The decrease in fluorescence intensity is in linear relationship with the concentrations of NO2-, NO3- and Fe3+, in the ranges of 0.015-1.11 mM, 0.072-0.60 mM and 2.9-176 muMu, respectively.	Nitrogen Dioxide	92-95	NBL1, DAN family BMP antagonist	Homo sapiens	98-101
30463387-5	2018	A pooled effect (percentage change) was observed, with a 1 mug/m3 increase in NO2 associated with a significant 1.25% change (95% CI: 0.67, 1.84; I2 = 0.00%, p = 0.07) in the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and a 0.60% change (95% CI: 0.17, 1.03; I2 = 30.94%, p = 0.27) in insulin.	Nitrogen Dioxide	78-81	insulin	Homo sapiens	207-214
30463387-5	2018	A pooled effect (percentage change) was observed, with a 1 mug/m3 increase in NO2 associated with a significant 1.25% change (95% CI: 0.67, 1.84; I2 = 0.00%, p = 0.07) in the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and a 0.60% change (95% CI: 0.17, 1.03; I2 = 30.94%, p = 0.27) in insulin.	Nitrogen Dioxide	78-81	insulin	Homo sapiens	302-309
30056252-10	2018	Subsequently, incubation with either MCR antagonists significantly augmented NO2/NO3 levels (stable NO metabolites) and this was attenuated by silencing of MCR or tunicamycin.	Nitrogen Dioxide	77-80	nuclear receptor subfamily 3 group C member 2	Homo sapiens	37-40
30566098-3	2018	NO2-, NO3-, Fe3+ and Fe2+ extensively present in natural water can accelerate CN-1 photoconversion via generating  OH, which may induce indirect photooxidation of CN-1.	Nitrogen Dioxide	0-3	5'-nucleotidase, cytosolic IA	Homo sapiens	78-82
30566098-3	2018	NO2-, NO3-, Fe3+ and Fe2+ extensively present in natural water can accelerate CN-1 photoconversion via generating  OH, which may induce indirect photooxidation of CN-1.	Nitrogen Dioxide	0-3	5'-nucleotidase, cytosolic IA	Homo sapiens	163-167
30285424-2	2018	Functionalization of MFM-102 with -NO2 groups on phenyl groups leads to a 15% reduction in BET surface area in MFM-102-NO2.	Nitrogen Dioxide	35-38	delta/notch like EGF repeat containing	Homo sapiens	91-94
30319134-10	2018	In contrast, testicular damages were attenuated in the NO2- treatment groups, which were caused by reduction in superoxide and peroxynitrite levels and an inhibition of caspase-3-dependent apoptosis.	Nitrogen Dioxide	55-58	caspase 3	Rattus norvegicus	169-178
30584441-1	2018	Context: We describe here the contributions of the Tehran lipid and glucose study (TLGS) to understanding different aspects of the nitrate (NO3)-nitrite (NO2)-nitric oxide (NO) pathway in health and disease.	Nitrogen Dioxide	154-157	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
30045620-4	2018	The results provided by the stochastic microsensors were in agreement with those obtained by utilization of standard methods, recoveries higher than 99.00% and RSD lower than 1.00%, proving that the method can be reliable used for simultaneous assay of NO2- and NO3- in water samples.	Nitrogen Dioxide	253-256	NBL1, DAN family BMP antagonist	Homo sapiens	262-265
29982129-8	2018	The largest short- and long-term associations were observed for ferritin in response to nitrogen dioxide exposure (1.4%, 95% confidence interval [CI] 0.3-2.5) and fibrinogen exposed to particles &lt; 2.5 mum (3.4%, 95% CI 3.0-3.8), respectively.	Nitrogen Dioxide	88-104	fibrinogen beta chain	Homo sapiens	163-173
29860091-3	2018	Also, this review focuses on the development of electrochemical label-free immunosensor for SOD1 and the recent advances in biosensing assay methods based on their catalytic and biological functions with various substrates including reactive oxygen species (superoxide anion radical, hydrogen peroxide), nitric oxide metabolites (nitrite, nitrate) and thiols using thiol oxidase activity.	Nitrogen Dioxide	330-337	superoxide dismutase 1	Homo sapiens	92-96
30257516-5	2018	The calculated Debye length of the SnO disk in presence of NO2 is reported for the first time.	Nitrogen Dioxide	59-62	strawberry notch homolog 2	Homo sapiens	35-38
30099933-11	2018	CONCLUSIONS:: A NO3--rich meal, consumed with or without an alcoholic beverage, increases plasma [NO2-] and lowers systemic BP for 2-3 h post ingestion.	Nitrogen Dioxide	98-101	NBL1, DAN family BMP antagonist	Homo sapiens	16-19
30454998-6	2018	In addition, the inherent minerals enhanced the release of HCN and NH3, both leading to increased NO2 release, and the release of H2S and COS was also promoted while the release of CH3SH, SO2 and CS2 was mitigated.	Nitrogen Dioxide	98-101	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	59-62
30030885-4	2018	The exposed calixarenes can be used for the visual detection and encapsulation of NO2 through the formation of deeply colored charge-transfer complexes inside the MOF.	Nitrogen Dioxide	82-85	lysine acetyltransferase 8	Homo sapiens	163-166
30030885-6	2018	Finally, the MOF was used as a sensor material in a home-made sensor cell and showed high sensitivity for NO2 .	Nitrogen Dioxide	106-109	lysine acetyltransferase 8	Homo sapiens	13-16
30237506-6	2018	Presented NO3- reducing bacterial granules inhibit rebar corrosion by producing the anodic corrosion inhibitor NO2- and meanwhile heal a 300-microm-wide crack in 28 days.	Nitrogen Dioxide	111-114	NBL1, DAN family BMP antagonist	Homo sapiens	10-13
30004232-1	2018	3,3,3-Trihalogeno-1-nitropropenes C(Hal3)CH CH(NO2) (Hal = F, Cl, Br) in reaction with arenes in the superacid CF3SO3H (TfOH) at room temperature in 1 h afford 3,3,3-trihalogeno-1,2-diarylpropan-1-one oximes C(Hal3)CH(Ar)-C(Ar) NOH (CHal3-oximes) in yields of 23-99%.	Nitrogen Dioxide	47-50	histidine ammonia-lyase	Homo sapiens	36-39
30039962-7	2018	Conversion of up to 67% of NO3-, with low NO2- (0.7-11 muM) and NH3 formation (&lt;10 muM), and low energy consumption obtained in this study suggest that Pd-Cu/REMs are a promising technology for distributed water treatment.	Nitrogen Dioxide	42-45	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
29807159-2	2018	A possible mechanism linking the oral microbiota to health is the nitrate (NO3-)-nitrite (NO2-)-nitric oxide (NO) pathway, which relies on oral bacteria to reduce NO3- to NO2-.	Nitrogen Dioxide	90-93	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
30246778-12	2018	The level of NO3-/NO2- ratio, was of 108.95 +- 12.05 nM/ml in controls vs. 170.04 +- 18.76 nM/ml in MS (p = 0.002), NO2- was of 33.78 +- 3.41 vs. 43.95 +- 2.59 nM/ml (p = 0.03), citrulline 62.65 +- 3.46 vs. 72.81 +- 4.35 muMol/ml (p = 0.06).	Nitrogen Dioxide	18-21	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
30246778-12	2018	The level of NO3-/NO2- ratio, was of 108.95 +- 12.05 nM/ml in controls vs. 170.04 +- 18.76 nM/ml in MS (p = 0.002), NO2- was of 33.78 +- 3.41 vs. 43.95 +- 2.59 nM/ml (p = 0.03), citrulline 62.65 +- 3.46 vs. 72.81 +- 4.35 muMol/ml (p = 0.06).	Nitrogen Dioxide	116-119	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
29807159-2	2018	A possible mechanism linking the oral microbiota to health is the nitrate (NO3-)-nitrite (NO2-)-nitric oxide (NO) pathway, which relies on oral bacteria to reduce NO3- to NO2-.	Nitrogen Dioxide	90-93	NBL1, DAN family BMP antagonist	Homo sapiens	163-166
29807159-2	2018	A possible mechanism linking the oral microbiota to health is the nitrate (NO3-)-nitrite (NO2-)-nitric oxide (NO) pathway, which relies on oral bacteria to reduce NO3- to NO2-.	Nitrogen Dioxide	171-174	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
29807159-2	2018	A possible mechanism linking the oral microbiota to health is the nitrate (NO3-)-nitrite (NO2-)-nitric oxide (NO) pathway, which relies on oral bacteria to reduce NO3- to NO2-.	Nitrogen Dioxide	171-174	NBL1, DAN family BMP antagonist	Homo sapiens	163-166
29807159-7	2018	NO3- supplementation increased plasma concentration of NO2- and reduced systemic blood pressure in old (70-79 yrs), but not young (18-22 yrs), participants.	Nitrogen Dioxide	55-58	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
29807159-8	2018	High abundances of Rothia and Neisseria and low abundances of Prevotella and Veillonella were correlated with greater increases in plasma [NO2-] in response to NO3- supplementation.	Nitrogen Dioxide	139-142	NBL1, DAN family BMP antagonist	Homo sapiens	160-163
29993243-2	2018	It was found that the promotion effect of NH3 was more favorable for the formation of NO3- (or SO42-) and NH4+ on acidic alpha-Fe2O3 and alpha-Al2O3 due to acid-base interactions between NO2 with NH3 or between SO2 and NH3, while this effect was weaker on basic CaO and MgO possibly due to their basic nature.	Nitrogen Dioxide	187-190	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
30288353-10	2018	Elevation of two pathways, NO2-dependent IL 12 pathway in NK cells and T cytotoxic cell surface molecules, significantly correlated with a higher rate of MUC16 mutations and a significantly favorable patients" prognosis.	Nitrogen Dioxide	27-30	mucin 16, cell surface associated	Homo sapiens	154-159
29993243-7	2018	On acidic Al2O3, the favorable adsorption of NH3 on the surface as well as the existence of NO2 with an oxidizing capability synergistically promoted the formation of SO42-, NO3-, and NH4+.	Nitrogen Dioxide	92-95	NBL1, DAN family BMP antagonist	Homo sapiens	174-177
29655107-8	2018	Nitrogenated and hydrogenated byproducts were formed in the early stage of degradation by OH or NO2 radicals, and these byproducts were subsequently degraded into smaller compounds with further reaction during UV-C/NO3- and UV-C/NO3-/CO32-/HCO3- reactions.	Nitrogen Dioxide	96-99	NBL1, DAN family BMP antagonist	Homo sapiens	215-218
30137121-6	2018	NO2, when analyzed in single pollutant model shown to be significant at lag 2 and 3 and when analyzed in the multi-pollutant model it shown to be significant at lags 2 up to 5, and lag 7 with relative risk between 1.05 and 1.09 per 10 mug/m3 increase in NO2 concentration, with an excess of 150 hospital admission and substantial increase in costs to Public Health System.	Nitrogen Dioxide	0-3	granulysin	Homo sapiens	72-83
30040397-1	2018	Pentavalent actinyl nitrate complexes AnVO2(NO3)2- were produced by elimination of two NO2 from AnIII(NO3)4- for An = Pu, Am, Cm, Bk, and Cf.	Nitrogen Dioxide	87-90	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
30040397-1	2018	Pentavalent actinyl nitrate complexes AnVO2(NO3)2- were produced by elimination of two NO2 from AnIII(NO3)4- for An = Pu, Am, Cm, Bk, and Cf.	Nitrogen Dioxide	87-90	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
29905749-0	2018	Highly sensitive and on-site NO2 SERS sensors operated under ambient conditions.	Nitrogen Dioxide	29-32	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	33-37
29864505-11	2018	Plasma NO3- and NO2-were increased following NO3- supplementation in older adults (P &lt; 0.01).	Nitrogen Dioxide	16-19	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
29524892-4	2018	The results of isotopic tracing and microbial diversity analysis indicated that NH4+ was first oxidized to NO2- by Fe(III), then NO3- was reduced to NO2- and N2 by the Fe(II) produced in Feammox process, and finally, the NO2- produced in NAFO process underwent an Anammox process with the remaining NH4+ to yield N2.	Nitrogen Dioxide	149-152	NBL1, DAN family BMP antagonist	Homo sapiens	129-132
29524892-4	2018	The results of isotopic tracing and microbial diversity analysis indicated that NH4+ was first oxidized to NO2- by Fe(III), then NO3- was reduced to NO2- and N2 by the Fe(II) produced in Feammox process, and finally, the NO2- produced in NAFO process underwent an Anammox process with the remaining NH4+ to yield N2.	Nitrogen Dioxide	149-152	NBL1, DAN family BMP antagonist	Homo sapiens	129-132
29923718-2	2018	Both reactions with NO and NO2 lead to exergonic formation of adducts, which subsequently overcome low energy barriers to form SO3 + NO3- and SO4- + NO, with rate constants of 6.9 x 10-10 and 6.3 x 10-10 cm3 molecule-1 s-1, respectively.	Nitrogen Dioxide	27-30	NBL1, DAN family BMP antagonist	Homo sapiens	133-136
29905749-2	2018	In the current work, we developed a high-performance (limit of detection: 0.1 ppm), on-site, rapid NO2 gas sensor that could be operated under ambient conditions by combining a highly sensitive 3D porous SERS substrate and a handheld Raman spectrometer.	Nitrogen Dioxide	99-102	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	204-208
29652218-5	2018	Results indicate that with an (empty bed residence time (EBRT) of 0.15 sec for the gas through the GAC-packed space, around 60% of the influent NO2 of 54 ppm could be removed, and 47% of the removed NO2 was converted by and desorbed from the carbon as NO.	Nitrogen Dioxide	144-147	glutaminase	Homo sapiens	99-102
29740672-5	2018	The colorimetric assay"s limit of detection for Sn2+ and the lowest concentration of NO2- detectable by the assay were found to be 27.5 nM and 0.1 muM, respectively.	Nitrogen Dioxide	85-88	latexin	Homo sapiens	147-150
29740672-6	2018	The assay permits the visual detection of Sn2+ and NO2- down to concentrations as low as 2 muM and 25 muM, respectively.	Nitrogen Dioxide	51-54	latexin	Homo sapiens	91-94
29740672-6	2018	The assay permits the visual detection of Sn2+ and NO2- down to concentrations as low as 2 muM and 25 muM, respectively.	Nitrogen Dioxide	51-54	latexin	Homo sapiens	102-105
29652218-8	2018	In practice, with an EBRT of 0.20 sec, a conversion capacity of 0.80 kg NO2 (kg GAC)-1 with an influent NO2 of 40 ppm can be used as a basis for system design.	Nitrogen Dioxide	104-107	glutaminase	Homo sapiens	80-83
29652218-10	2018	This study provides a simple process for the adsorptive conversion of NO2 in caustic-treated waste gases vented from metal-etching operations through a GAC column.	Nitrogen Dioxide	70-73	glutaminase	Homo sapiens	152-155
29652218-11	2018	With an EBRT of 0.20 sec, a conversion capacity of 0.80 kg NO2 (kg GAC)-1 with an influent NO2 of 40 ppm can be used as a basis for system design.	Nitrogen Dioxide	59-62	glutaminase	Homo sapiens	67-70
29652218-11	2018	With an EBRT of 0.20 sec, a conversion capacity of 0.80 kg NO2 (kg GAC)-1 with an influent NO2 of 40 ppm can be used as a basis for system design.	Nitrogen Dioxide	91-94	glutaminase	Homo sapiens	67-70
29652218-5	2018	Results indicate that with an (empty bed residence time (EBRT) of 0.15 sec for the gas through the GAC-packed space, around 60% of the influent NO2 of 54 ppm could be removed, and 47% of the removed NO2 was converted by and desorbed from the carbon as NO.	Nitrogen Dioxide	199-202	glutaminase	Homo sapiens	99-102
29652218-6	2018	GAC used in the present study could be regenerated at least twice to restore its capacity for NO2 adsorption.	Nitrogen Dioxide	94-97	glutaminase	Homo sapiens	0-3
29652218-8	2018	In practice, with an EBRT of 0.20 sec, a conversion capacity of 0.80 kg NO2 (kg GAC)-1 with an influent NO2 of 40 ppm can be used as a basis for system design.	Nitrogen Dioxide	72-75	glutaminase	Homo sapiens	80-83
29559479-3	2018	We found that ibrutinib and the novel Btk inhibitors acalabrutinib and ONO/GS-4059 block GPVI-dependent static platelet aggregation in blood exposed to human plaque homogenate and collagen but not to ADP or arachidonic acid.	Nitrogen Dioxide	71-74	Bruton tyrosine kinase	Homo sapiens	38-41
30003078-3	2018	The satisfactory PLS1 regression models between sensor array optical response and analyte concentration were obtained for Cd2+, Cu2+, Zn2+, and NO2- ions in all the range of tested concentrations.	Nitrogen Dioxide	144-147	plastin 1	Homo sapiens	17-21
29559479-3	2018	We found that ibrutinib and the novel Btk inhibitors acalabrutinib and ONO/GS-4059 block GPVI-dependent static platelet aggregation in blood exposed to human plaque homogenate and collagen but not to ADP or arachidonic acid.	Nitrogen Dioxide	71-74	glycoprotein VI platelet	Homo sapiens	89-93
29965496-4	2018	The order of the concentration from high to low was SO42- &gt; NO3- &gt; NH4+ &gt; Ca2+ &gt; NO2- &gt; Cl- &gt; Na+ &gt; K+ &gt; Mg2+.	Nitrogen Dioxide	93-96	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
29729279-3	2018	Renal CAII and CAIV are involved in the reabsorption of nitrite, the autoxidation product of the signalling molecule nitric oxide (NO): 4 NO + O2 + 2 H2O   4 ONO- + 4 H+.	Nitrogen Dioxide	158-161	carbonic anhydrase 2	Homo sapiens	6-10
29729279-3	2018	Renal CAII and CAIV are involved in the reabsorption of nitrite, the autoxidation product of the signalling molecule nitric oxide (NO): 4 NO + O2 + 2 H2O   4 ONO- + 4 H+.	Nitrogen Dioxide	158-161	carbonic anhydrase 4	Homo sapiens	15-19
29729279-4	2018	Bovine and human CAII and CAIV have been reported to exert nitrite reductase and nitrous anhydride activity: 2 NO2- + 2 H+   [2 HONO]   N2O3 + H2O.	Nitrogen Dioxide	111-114	carbonic anhydrase 2	Homo sapiens	17-21
29729279-4	2018	Bovine and human CAII and CAIV have been reported to exert nitrite reductase and nitrous anhydride activity: 2 NO2- + 2 H+   [2 HONO]   N2O3 + H2O.	Nitrogen Dioxide	111-114	carbonic anhydrase 4	Homo sapiens	26-30
29501036-0	2018	Maternal exposure to NO2 enhances airway sensitivity to allergens in BALB/c mice through the JAK-STAT6 pathway.	Nitrogen Dioxide	21-24	signal transducer and activator of transcription 6	Mus musculus	97-102
28730729-8	2018	Among patients with NAFLD at baseline, CK-18 increased from 140 U/L to 200 U/L (a 1.5 standard deviation increase in CK-18) as NO2 increased from 8 to 10 ppb.	Nitrogen Dioxide	127-130	keratin 18	Homo sapiens	39-44
28730729-8	2018	Among patients with NAFLD at baseline, CK-18 increased from 140 U/L to 200 U/L (a 1.5 standard deviation increase in CK-18) as NO2 increased from 8 to 10 ppb.	Nitrogen Dioxide	127-130	keratin 18	Homo sapiens	117-122
29761189-5	2018	The H2 is released by AlH3 firstly and then it reacts with NO2 and CO2 from the decomposition of RDX, leading to an increase of H2O, NO and CO.	Nitrogen Dioxide	59-62	radixin	Homo sapiens	97-100
29785426-2	2018	Experimentalists have also synthesized several derivatives, e.g., [Fe(OTf)2(E,HPytacn)] (E = -Cl (2), -CO2Et (3) and -NO2 (4)) and [Fe(OTf)2 (E,RPytacn)] (R = -F (5) and R = -Me (6)), and proposed that the E-substituted electron-withdrawing groups could improve the catalytic efficiency.	Nitrogen Dioxide	118-121	POU class 2 homeobox 2	Homo sapiens	70-75
29413964-6	2018	Taken together, our results demonstrate that the formation of NO2-CLA has the potential to function as an adaptive response capable of not only modulating inflammation amplitude but also protecting neighboring tissues via the expression of Nrf2-dependent genes.	Nitrogen Dioxide	62-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	240-244
28503938-7	2018	Additionally we compared the interactions with hGST P1-1 enzyme of newly synthesized compound Vh (bearing CF3 group) and previously synthesized compound 5f (bearing NO2 group).	Nitrogen Dioxide	165-168	glutathione S-transferase pi 1	Homo sapiens	47-56
29277016-5	2018	We demonstrate that 4F and Cl/NO2-HDL act on scavenger receptor type I (SR-B1) using human aorta endothelial cells (HAEC) and SR-B1 (-/-) mouse aortic endothelial cells.	Nitrogen Dioxide	30-33	scavenger receptor class B member 1	Homo sapiens	72-77
29277016-5	2018	We demonstrate that 4F and Cl/NO2-HDL act on scavenger receptor type I (SR-B1) using human aorta endothelial cells (HAEC) and SR-B1 (-/-) mouse aortic endothelial cells.	Nitrogen Dioxide	30-33	scavenger receptor class B member 1	Homo sapiens	126-131
29408081-2	2018	In the denitrification experiments, the highest obtained NO3--N removal rate was 20.9 mg/l d. In the experiments with the biomass enriched on NO2-, a NO2--N removal rate of 10.7 mg/l d was achieved even at a NO2--N concentration as high as 240 mg/l.	Nitrogen Dioxide	142-145	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
29690649-0	2018	Responses to the Selective Bruton"s Tyrosine Kinase (BTK) Inhibitor Tirabrutinib (ONO/GS-4059) in Diffuse Large B-cell Lymphoma Cell Lines.	Nitrogen Dioxide	82-85	Bruton tyrosine kinase	Homo sapiens	27-51
29690649-0	2018	Responses to the Selective Bruton"s Tyrosine Kinase (BTK) Inhibitor Tirabrutinib (ONO/GS-4059) in Diffuse Large B-cell Lymphoma Cell Lines.	Nitrogen Dioxide	82-85	inhibitor of Bruton tyrosine kinase	Homo sapiens	53-56
29623333-1	2018	SnS2 nanosheets with unique properties are excellent candidate materials for fabricating high-performance NO2 gas sensors.	Nitrogen Dioxide	106-109	sodium voltage-gated channel alpha subunit 11	Homo sapiens	0-4
29623333-4	2018	The fabricated SnS2/SnO2 sensor exhibited ultrahigh response (resistance ratio = 51.1) toward 1 ppm NO2 at 100  C, roughly 10.2 times higher than that of pure SnS2 nanoflowers.	Nitrogen Dioxide	100-103	sodium voltage-gated channel alpha subunit 11	Homo sapiens	15-19
29623333-4	2018	The fabricated SnS2/SnO2 sensor exhibited ultrahigh response (resistance ratio = 51.1) toward 1 ppm NO2 at 100  C, roughly 10.2 times higher than that of pure SnS2 nanoflowers.	Nitrogen Dioxide	100-103	sodium voltage-gated channel alpha subunit 11	Homo sapiens	159-163
29623333-5	2018	The excellent and enhanced NO2 sensing performances of hierarchical SnS2/SnO2 nanocomposites were attributed to the novel hierarchical structure of SnS2 and the nanoheterojunction between SnS2 and the ultrafine SnO2 nanoparticles.	Nitrogen Dioxide	27-30	sodium voltage-gated channel alpha subunit 11	Homo sapiens	68-72
29623333-5	2018	The excellent and enhanced NO2 sensing performances of hierarchical SnS2/SnO2 nanocomposites were attributed to the novel hierarchical structure of SnS2 and the nanoheterojunction between SnS2 and the ultrafine SnO2 nanoparticles.	Nitrogen Dioxide	27-30	sodium voltage-gated channel alpha subunit 11	Homo sapiens	148-152
29623333-5	2018	The excellent and enhanced NO2 sensing performances of hierarchical SnS2/SnO2 nanocomposites were attributed to the novel hierarchical structure of SnS2 and the nanoheterojunction between SnS2 and the ultrafine SnO2 nanoparticles.	Nitrogen Dioxide	27-30	sodium voltage-gated channel alpha subunit 11	Homo sapiens	148-152
29504403-1	2018	1,3-Disulfonic acid imidazolium nitrate {[Dsim]NO3} was prepared and characterized as a new ionic liquid and nitrating agent for the ipso-nitration of various arylboronic acids and nitro-Hunsdiecker reaction of different alpha,beta-unsaturated acids and benzoic acid derivatives, by in situ generation of NO2 to give various nitroarenes and nitroolefins without using any cocatalysts and solvents under mild conditions.	Nitrogen Dioxide	305-308	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
29620895-6	2018	The initial reaction path of thermal decomposition of CL-20 is N-NO2 cleavage to form NO2, followed by C-N cleavage, leading to the destruction of the cage structure.	Nitrogen Dioxide	65-68	epithelial membrane protein 1	Homo sapiens	54-59
29620895-6	2018	The initial reaction path of thermal decomposition of CL-20 is N-NO2 cleavage to form NO2, followed by C-N cleavage, leading to the destruction of the cage structure.	Nitrogen Dioxide	86-89	epithelial membrane protein 1	Homo sapiens	54-59
29417167-0	2018	Maternal NO2 exposure induces cardiac hypertrophy in male offspring via ROS-HIF-1alpha transcriptional regulation and aberrant DNA methylation modification of Csx/Nkx2.5.	Nitrogen Dioxide	9-12	hypoxia inducible factor 1, alpha subunit	Mus musculus	76-86
29417167-0	2018	Maternal NO2 exposure induces cardiac hypertrophy in male offspring via ROS-HIF-1alpha transcriptional regulation and aberrant DNA methylation modification of Csx/Nkx2.5.	Nitrogen Dioxide	9-12	NK2 homeobox 5	Mus musculus	159-162
29417167-0	2018	Maternal NO2 exposure induces cardiac hypertrophy in male offspring via ROS-HIF-1alpha transcriptional regulation and aberrant DNA methylation modification of Csx/Nkx2.5.	Nitrogen Dioxide	9-12	NK2 homeobox 5	Mus musculus	163-169
29408081-4	2018	S0-driven denitrification was modeled as a two-step process in order to explicitly account for the sequential reduction of NO3- to NO2- and then to N2 by denitrifying bacteria.	Nitrogen Dioxide	131-134	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
29306190-3	2018	Compared to SnO2-RGO hybrids, the sensor based on Pd-SnO2-RGO hybrids exhibited higher sensitivity at room temperature, where the response to 1 ppm NO2 was 3.92 with the response time and recovery time being 13 s and 105 s. Moreover, such sensor exhibited excellent selectivity, and low detection limit (50 ppb).	Nitrogen Dioxide	148-151	strawberry notch homolog 2	Homo sapiens	12-15
29520994-6	2018	Moreover, the NO2 gas response of the gas sensing device with vertically self-formed SnS2 nanosheets is more than two orders of magnitude higher than that of a similar exfoliated SnS2 -based device.	Nitrogen Dioxide	14-17	sodium voltage-gated channel alpha subunit 11	Homo sapiens	85-89
29520994-6	2018	Moreover, the NO2 gas response of the gas sensing device with vertically self-formed SnS2 nanosheets is more than two orders of magnitude higher than that of a similar exfoliated SnS2 -based device.	Nitrogen Dioxide	14-17	sodium voltage-gated channel alpha subunit 11	Homo sapiens	179-183
29326005-5	2018	Sufficient CH4 recovery of 101 L-CH4 kg-COD-1 was achieved, indicating that the use of NO2--exposed sludge is effective to avoid NO2- inhibition on methanogenesis.	Nitrogen Dioxide	87-90	component of oligomeric golgi complex 4	Homo sapiens	40-45
29326005-5	2018	Sufficient CH4 recovery of 101 L-CH4 kg-COD-1 was achieved, indicating that the use of NO2--exposed sludge is effective to avoid NO2- inhibition on methanogenesis.	Nitrogen Dioxide	129-132	component of oligomeric golgi complex 4	Homo sapiens	40-45
29306190-1	2018	In this paper, we demonstrate room-temperature NO2 gas sensors using Pd nanoparticles (NPs) and SnO2 NPs decorated reduced graphene oxide (Pd-SnO2-RGO) hybrids as sensing materials.	Nitrogen Dioxide	47-50	strawberry notch homolog 2	Homo sapiens	96-99
29360963-3	2018	Nitrite initially accumulated in all three soils; its subsequent decline or slowing of the accumulation of the NO2- pool by 24 h was accompanied by an increase in the size of the nitrate (NO3-) pool, indicating a change in NO2- oxidation kinetics.	Nitrogen Dioxide	223-226	NBL1, DAN family BMP antagonist	Homo sapiens	188-191
29402637-10	2018	It is concluded that activity of UGT within the endometrium is affected by the contralateral or ipsilateral location of the CL, and collection of endometrial perfusion data using a laser Doppler probe could be a viable measurement technique as indicated by associated nitrite concentrations in the present study.	Nitrogen Dioxide	268-275	solute carrier family 35 member A2	Bos taurus	33-36
29355738-3	2018	Beyond these CO2 and pH-linked roles, it has been postulated that CA II might also reduce nitrite (NO2-) to nitric oxide (NO), as bicarbonate and NO2- both exhibit sp2 molecular geometry and NO also plays an important role in vasodilation and regulation of blood pressure.	Nitrogen Dioxide	99-102	carbonic anhydrase 2	Bos taurus	66-71
29355738-3	2018	Beyond these CO2 and pH-linked roles, it has been postulated that CA II might also reduce nitrite (NO2-) to nitric oxide (NO), as bicarbonate and NO2- both exhibit sp2 molecular geometry and NO also plays an important role in vasodilation and regulation of blood pressure.	Nitrogen Dioxide	146-149	carbonic anhydrase 2	Bos taurus	66-71
29355738-7	2018	measuring NO generation by two methods, and to examine the structure of CA II in complex with NO2- in the presence and absence of dorzolamide.	Nitrogen Dioxide	94-97	carbonic anhydrase 2	Bos taurus	72-77
29121601-5	2018	The concentrations of SO42-, NH4+, NO3- and organic aerosol were positively related to the concentration of added NO2.	Nitrogen Dioxide	114-117	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
29248688-7	2018	The linearity ranges were found to be 1.5 to 2.8 x 103 mug L-1(NO3-) and 1.2 to 1.9 x 103 mug L-1 (NO2-).	Nitrogen Dioxide	99-102	immunoglobulin kappa variable 1-16	Homo sapiens	94-97
29467204-7	2018	The proportion of the association between NO2 on VCP mediated by FEV1 was 6.2% and this was higher in never smokers (7.2%) and non-carriers of the APOE-epsilon4 allele (11.2%).	Nitrogen Dioxide	42-45	apolipoprotein E	Homo sapiens	147-151
29353485-7	2018	Formation of 4-nitrocatechol is initiated by abstraction of a phenolic H atom by an OH or NO3 radical to form a beta-hydroxyphenoxy/o-semiquinone radical, which then reacts with NO2 to form the final product.	Nitrogen Dioxide	178-181	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
29131928-8	2018	RESULTS: NO3- /NO2- nitrogen is routed to the 15 Nalpha position of N2 O in the azide reaction; hence the delta15 Nalpha value should be used for N2 O laser spectrometry results.	Nitrogen Dioxide	15-18	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
29362749-3	2018	Dinitrogen tetroxide showed a stronger affinity than nitrogen dioxide in all the zeolites due to size effects, but exclusive adsorption sites in MOR allowed the adsorption of nitrogen dioxide with no competition at these sites.	Nitrogen Dioxide	175-191	opioid receptor mu 1	Homo sapiens	145-148
29362749-6	2018	Preferential adsorption sites in MOR lead to an unusually strong selective adsorption towards nitrogen dioxide, demonstrating that the topological structure has a crucial influence on the composition of the mixture and must be carefully considered in systems containing nitrogen dioxide.	Nitrogen Dioxide	94-110	opioid receptor mu 1	Homo sapiens	33-36
29362749-6	2018	Preferential adsorption sites in MOR lead to an unusually strong selective adsorption towards nitrogen dioxide, demonstrating that the topological structure has a crucial influence on the composition of the mixture and must be carefully considered in systems containing nitrogen dioxide.	Nitrogen Dioxide	270-286	opioid receptor mu 1	Homo sapiens	33-36
28916479-5	2018	NO3- intake increased (P &lt; .05-0.001) plasma NO3- and NO2- and breath NO by 1469 +- 245%, 105 +- 34%, and 60 +- 18%, respectively.	Nitrogen Dioxide	57-60	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
29317916-8	2018	Additionally, at the 90-day time period (90 days prior to the blood draw), Foxp3 methylation was positively associated with NO2, CO, and PM2.5 exposures (p = 0.001, p = 0.001, and p = 0.012, respectively).	Nitrogen Dioxide	124-127	forkhead box P3	Homo sapiens	75-80
28942315-8	2018	The chemically produced HO2 was largely converted to OH by the reactions with NO (HO2+NO=OH+NO2) from BB emissions.	Nitrogen Dioxide	92-95	heme oxygenase 2	Homo sapiens	24-27
28942315-8	2018	The chemically produced HO2 was largely converted to OH by the reactions with NO (HO2+NO=OH+NO2) from BB emissions.	Nitrogen Dioxide	92-95	heme oxygenase 2	Homo sapiens	82-85
29098611-8	2018	Arginase I levels were slightly increased, whereas L-arginine levels were significantly reduced, and these changes were followed by reductions in NO2- levels.	Nitrogen Dioxide	146-149	arginase, liver	Mus musculus	0-10
29257867-1	2018	The fundamental biogeochemical cycle of nitrogen includes cytochrome c nitrite reductase, which catalyzes the reduction of nitrite ions to ammonium with eight protons and six electrons (NO2- + 8H+ + 6e-   NH4+ + 2H2O).	Nitrogen Dioxide	186-189	cytochrome c, somatic	Homo sapiens	58-70
29317916-11	2018	Conclusions: Short-term and long-term exposures to high levels of CO, NO2, and PM2.5 were associated with alterations in differentially methylated regions of Foxp3.	Nitrogen Dioxide	70-73	forkhead box P3	Homo sapiens	158-163
28728027-4	2017	The Pb(NO3)2-treated device exhibited superior sensing performance of 58.8 under 5ppm NO2 at room-temperature, with the response and recovery time of 28 and 106s.	Nitrogen Dioxide	86-89	NBL1, DAN family BMP antagonist	Homo sapiens	7-10
29368802-12	2018	We conclude that the magnitude of the dietary NO3- -induced increase in muscle power is dependent upon the magnitude of the resulting increase in plasma NO2- and possibly female sex.	Nitrogen Dioxide	153-156	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
28917735-1	2018	For the first time, a novel green method using Zein biopolymeric nanoparticles as a green dispersive solid-phase extractor is reported for the separation and preconcentration of trace amount of nitrite (NO2-) ions in ppb levels.	Nitrogen Dioxide	203-206	zein	Zea mays	47-51
28986735-9	2017	Furthermore, NO2 exposure promoted the increase in the expression of mucin gene (MUC5AC) and pro-inflammatory factors [interleukin (IL)-1beta, intercellular adhesion molecule-1 (ICAM-1), and IL-6] as well as serum OVA-specific immunoglobulin E (IgE) production.	Nitrogen Dioxide	13-16	solute carrier family 13 member 2	Rattus norvegicus	69-74
28986735-9	2017	Furthermore, NO2 exposure promoted the increase in the expression of mucin gene (MUC5AC) and pro-inflammatory factors [interleukin (IL)-1beta, intercellular adhesion molecule-1 (ICAM-1), and IL-6] as well as serum OVA-specific immunoglobulin E (IgE) production.	Nitrogen Dioxide	13-16	mucin 5AC, oligomeric mucus/gel-forming	Rattus norvegicus	81-87
28986735-9	2017	Furthermore, NO2 exposure promoted the increase in the expression of mucin gene (MUC5AC) and pro-inflammatory factors [interleukin (IL)-1beta, intercellular adhesion molecule-1 (ICAM-1), and IL-6] as well as serum OVA-specific immunoglobulin E (IgE) production.	Nitrogen Dioxide	13-16	interleukin 1 beta	Rattus norvegicus	119-141
28986735-9	2017	Furthermore, NO2 exposure promoted the increase in the expression of mucin gene (MUC5AC) and pro-inflammatory factors [interleukin (IL)-1beta, intercellular adhesion molecule-1 (ICAM-1), and IL-6] as well as serum OVA-specific immunoglobulin E (IgE) production.	Nitrogen Dioxide	13-16	intercellular adhesion molecule 1	Rattus norvegicus	143-176
28986735-9	2017	Furthermore, NO2 exposure promoted the increase in the expression of mucin gene (MUC5AC) and pro-inflammatory factors [interleukin (IL)-1beta, intercellular adhesion molecule-1 (ICAM-1), and IL-6] as well as serum OVA-specific immunoglobulin E (IgE) production.	Nitrogen Dioxide	13-16	intercellular adhesion molecule 1	Rattus norvegicus	178-184
28986735-9	2017	Furthermore, NO2 exposure promoted the increase in the expression of mucin gene (MUC5AC) and pro-inflammatory factors [interleukin (IL)-1beta, intercellular adhesion molecule-1 (ICAM-1), and IL-6] as well as serum OVA-specific immunoglobulin E (IgE) production.	Nitrogen Dioxide	13-16	interleukin 6	Rattus norvegicus	191-195
28165641-1	2017	Nitrate (NO3-) supplementation resulting in higher plasma nitrite (NO2-) is reported to lower resting mean arterial blood pressure (MAP) and oxygen uptake (VO2 ) during submaximal exercise in non-athletic populations, whereas effects in general are absent in endurance-trained individuals.	Nitrogen Dioxide	67-70	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
29380952-1	2018	Dietary nitrate (NO3-) is converted to nitrite (NO2-) and can be further reduced to the vasodilator nitric oxide (NO) amid a low O2 environment.	Nitrogen Dioxide	48-51	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
30230951-1	2018	Exposure of Arabidopsis leaves to nitrogen dioxide (NO2) results in the selective nitration of specific proteins, such as PsbO1.	Nitrogen Dioxide	34-50	PS II oxygen-evolving complex 1	Arabidopsis thaliana	122-127
30230951-1	2018	Exposure of Arabidopsis leaves to nitrogen dioxide (NO2) results in the selective nitration of specific proteins, such as PsbO1.	Nitrogen Dioxide	52-55	PS II oxygen-evolving complex 1	Arabidopsis thaliana	122-127
29231879-4	2017	The present review summarizes the advances in the exploitation of these MoX2 materials as chemical sensors for the detection of typical environmental pollutants, such as NO2, NH3, CO and volatile organic compounds.	Nitrogen Dioxide	170-173	mesenchyme homeobox 2	Homo sapiens	72-76
28067100-10	2017	In turn, the pre- and post-exercise plasma concentrations of nitrite (NO2-) and nitrate (NO3-) were decreased in ApoE/LDLR-/- as compared to that in age-matched WT mice.	Nitrogen Dioxide	70-73	apolipoprotein E	Mus musculus	113-117
29035054-0	2017	Quantum Yields of Nitrite (NO2-) from the Photolysis of Nitrate (NO3-) in Ice at 313 nm.	Nitrogen Dioxide	27-30	NBL1, DAN family BMP antagonist	Homo sapiens	65-68
28067100-10	2017	In turn, the pre- and post-exercise plasma concentrations of nitrite (NO2-) and nitrate (NO3-) were decreased in ApoE/LDLR-/- as compared to that in age-matched WT mice.	Nitrogen Dioxide	70-73	low density lipoprotein receptor	Mus musculus	118-122
28658735-3	2017	NH3 was more reactive than NH4+ with hydroxyl radical (OH), and by a stepwise H2O2 addition method NH3/NH4+ can be completely converted to NOx-; NO2- underwent rapid oxidation to form NO3- when H2O2 was present, suggesting that it is an intermediate compound linking NH3/NH4+ and NO3-; but once H2O2 was depleted, NO3- can be gradually photo-reduced back to NO2- at high pH conditions.	Nitrogen Dioxide	145-148	NBL1, DAN family BMP antagonist	Homo sapiens	184-187
29074540-6	2017	Higher NO2 exposure was associated with lower forced vital capacity for carriers of the GSTT1 null genotype.TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults.	Nitrogen Dioxide	7-10	glutathione S-transferase theta 1	Homo sapiens	88-93
28895781-1	2017	Exposure of intact Arabidopsis leaves to 40 ppm nitrogen dioxide (NO2) in light resulted almost exclusively in nitration of PsbO1, PsbO2, and PsbP1 of photosystem II (PSII), with minor nitration of four non-PS II proteins, including peroxiredoxin II E, as reported previously.	Nitrogen Dioxide	48-64	PS II oxygen-evolving complex 1	Arabidopsis thaliana	124-129
28895781-1	2017	Exposure of intact Arabidopsis leaves to 40 ppm nitrogen dioxide (NO2) in light resulted almost exclusively in nitration of PsbO1, PsbO2, and PsbP1 of photosystem II (PSII), with minor nitration of four non-PS II proteins, including peroxiredoxin II E, as reported previously.	Nitrogen Dioxide	48-64	photosystem II subunit O-2	Arabidopsis thaliana	131-136
28895781-1	2017	Exposure of intact Arabidopsis leaves to 40 ppm nitrogen dioxide (NO2) in light resulted almost exclusively in nitration of PsbO1, PsbO2, and PsbP1 of photosystem II (PSII), with minor nitration of four non-PS II proteins, including peroxiredoxin II E, as reported previously.	Nitrogen Dioxide	48-64	photosystem II subunit P-1	Arabidopsis thaliana	142-147
28895781-1	2017	Exposure of intact Arabidopsis leaves to 40 ppm nitrogen dioxide (NO2) in light resulted almost exclusively in nitration of PsbO1, PsbO2, and PsbP1 of photosystem II (PSII), with minor nitration of four non-PS II proteins, including peroxiredoxin II E, as reported previously.	Nitrogen Dioxide	66-69	PS II oxygen-evolving complex 1	Arabidopsis thaliana	124-129
28895781-1	2017	Exposure of intact Arabidopsis leaves to 40 ppm nitrogen dioxide (NO2) in light resulted almost exclusively in nitration of PsbO1, PsbO2, and PsbP1 of photosystem II (PSII), with minor nitration of four non-PS II proteins, including peroxiredoxin II E, as reported previously.	Nitrogen Dioxide	66-69	photosystem II subunit O-2	Arabidopsis thaliana	131-136
28895781-1	2017	Exposure of intact Arabidopsis leaves to 40 ppm nitrogen dioxide (NO2) in light resulted almost exclusively in nitration of PsbO1, PsbO2, and PsbP1 of photosystem II (PSII), with minor nitration of four non-PS II proteins, including peroxiredoxin II E, as reported previously.	Nitrogen Dioxide	66-69	photosystem II subunit P-1	Arabidopsis thaliana	142-147
28658735-3	2017	NH3 was more reactive than NH4+ with hydroxyl radical (OH), and by a stepwise H2O2 addition method NH3/NH4+ can be completely converted to NOx-; NO2- underwent rapid oxidation to form NO3- when H2O2 was present, suggesting that it is an intermediate compound linking NH3/NH4+ and NO3-; but once H2O2 was depleted, NO3- can be gradually photo-reduced back to NO2- at high pH conditions.	Nitrogen Dioxide	145-148	NBL1, DAN family BMP antagonist	Homo sapiens	280-283
28658735-3	2017	NH3 was more reactive than NH4+ with hydroxyl radical (OH), and by a stepwise H2O2 addition method NH3/NH4+ can be completely converted to NOx-; NO2- underwent rapid oxidation to form NO3- when H2O2 was present, suggesting that it is an intermediate compound linking NH3/NH4+ and NO3-; but once H2O2 was depleted, NO3- can be gradually photo-reduced back to NO2- at high pH conditions.	Nitrogen Dioxide	145-148	NBL1, DAN family BMP antagonist	Homo sapiens	280-283
28658735-3	2017	NH3 was more reactive than NH4+ with hydroxyl radical (OH), and by a stepwise H2O2 addition method NH3/NH4+ can be completely converted to NOx-; NO2- underwent rapid oxidation to form NO3- when H2O2 was present, suggesting that it is an intermediate compound linking NH3/NH4+ and NO3-; but once H2O2 was depleted, NO3- can be gradually photo-reduced back to NO2- at high pH conditions.	Nitrogen Dioxide	358-361	NBL1, DAN family BMP antagonist	Homo sapiens	184-187
28732305-7	2017	Long-term exposures to NO2 and SO2 were associated with reduced high-density lipoproteins and apolipoprotein A1, e.g., 4.0% (1.7%, 6.3%) and 4.7% (2.8%, 6.6%) decrease per interquartile increment in prior one-year average NO2 concentration, respectively.	Nitrogen Dioxide	23-26	apolipoprotein A1	Homo sapiens	94-111
28739872-9	2017	Moreover, NO2-OA reduced the dephosphorylation of p38alpha by hematopoietic tyrosine phosphatase (HePTP).	Nitrogen Dioxide	10-13	mitogen activated protein kinase 14	Rattus norvegicus	50-58
28712959-14	2017	Similarly, an IQR (8.6 ppb) increase in NO2 was also significantly associated with diabetes prevalence (POR 1.27, 95% CI: 1.10, 1.48).	Nitrogen Dioxide	40-43	ADP ribosylation factor interacting protein 2	Homo sapiens	104-109
28704758-5	2017	Introduction of a NO2 (6d) or NH2 moiety (7d) decreased the GluN2B affinity.	Nitrogen Dioxide	18-21	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	60-66
28739872-9	2017	Moreover, NO2-OA reduced the dephosphorylation of p38alpha by hematopoietic tyrosine phosphatase (HePTP).	Nitrogen Dioxide	10-13	protein tyrosine phosphatase, non-receptor type 7	Rattus norvegicus	62-96
28739872-9	2017	Moreover, NO2-OA reduced the dephosphorylation of p38alpha by hematopoietic tyrosine phosphatase (HePTP).	Nitrogen Dioxide	10-13	protein tyrosine phosphatase, non-receptor type 7	Rattus norvegicus	98-103
28935613-11	2017	CONCLUSIONS: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene.	Nitrogen Dioxide	55-58	interleukin 4	Mus musculus	370-373
28773138-0	2017	Fabrication of Nanosized Island-Like CdO Crystallites-Decorated TiO2 Rod Nanocomposites via a Combinational Methodology and Their Low-Concentration NO2 Gas-Sensing Behavior.	Nitrogen Dioxide	148-151	cell adhesion associated, oncogene regulated	Homo sapiens	37-40
28705380-6	2017	An interquartile range increase in particulate matter &lt;10 microm in aerodynamic diameter, sulfur dioxide, nitrogen dioxide, and carbon monoxide concentrations on lag2 day was significantly associated with a 0.8% (95% CI 0.1%, 1.6%), 2.0% (95% CI 1.2%, 2.9%), 2.2% (95% CI 1.4%, 3.1%), and 1.1% (95% CI 0.4%, 1.8%) increase in AMI admissions, respectively.	Nitrogen Dioxide	109-125	granulysin	Homo sapiens	165-169
28780636-4	2017	NO3- and NO2- promoted the photoconversion of CN-2 owing to  OH generated by the photolysis of NO3- and NO2-; FA at a lower concentration promoted the photoconversion, but it had an inhibition effect at a higher concentration.	Nitrogen Dioxide	9-12	carnosine dipeptidase 2	Homo sapiens	46-50
28780636-4	2017	NO3- and NO2- promoted the photoconversion of CN-2 owing to  OH generated by the photolysis of NO3- and NO2-; FA at a lower concentration promoted the photoconversion, but it had an inhibition effect at a higher concentration.	Nitrogen Dioxide	9-12	NBL1, DAN family BMP antagonist	Homo sapiens	95-98
28780636-4	2017	NO3- and NO2- promoted the photoconversion of CN-2 owing to  OH generated by the photolysis of NO3- and NO2-; FA at a lower concentration promoted the photoconversion, but it had an inhibition effect at a higher concentration.	Nitrogen Dioxide	104-107	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
28780636-4	2017	NO3- and NO2- promoted the photoconversion of CN-2 owing to  OH generated by the photolysis of NO3- and NO2-; FA at a lower concentration promoted the photoconversion, but it had an inhibition effect at a higher concentration.	Nitrogen Dioxide	104-107	carnosine dipeptidase 2	Homo sapiens	46-50
28739973-7	2017	Coadministration of cLA with 15NO2- also impacted the pharmacokinetics and physiological effects of 15NO2-, with cLA administration suppressing plasma NO3-and NO2-levels, decreasing 15NO-deoxyhemoglobin formation, NO2-inhibition of platelet activation, and the vasodilatory actions of NO2-, while enhancing the formation of 9- and 12-15NO2-cLA.	Nitrogen Dioxide	31-34	NBL1, DAN family BMP antagonist	Homo sapiens	151-154
28710281-1	2017	Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure.	Nitrogen Dioxide	28-31	NBL1, DAN family BMP antagonist	Mus musculus	106-109
28710281-1	2017	Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure.	Nitrogen Dioxide	149-152	NBL1, DAN family BMP antagonist	Mus musculus	9-12
28710281-1	2017	Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure.	Nitrogen Dioxide	149-152	NBL1, DAN family BMP antagonist	Mus musculus	106-109
28710281-1	2017	Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure.	Nitrogen Dioxide	149-152	NBL1, DAN family BMP antagonist	Mus musculus	9-12
28710281-1	2017	Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure.	Nitrogen Dioxide	149-152	NBL1, DAN family BMP antagonist	Mus musculus	106-109
28737807-6	2017	Dot blotting results indicate that NPY is easily nitrated upon binding with heme when H2O2 and NO2- are present.	Nitrogen Dioxide	95-98	neuropeptide Y	Homo sapiens	35-38
29964605-7	2017	The proportion of ion to PM2.5 decreased in the order of NO3- &gt; SO42- &gt; NH4+ &gt; Cl- &gt; NO2-.	Nitrogen Dioxide	97-100	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
29964605-9	2017	The correlation analysis showed that NO3- and SO42- in the fine particle were significantly correlated with gaseous precursors NO2 and SO2, and also showed good correlations with relative humidity, visibility, wind speed and other weather conditions.	Nitrogen Dioxide	127-130	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
28604897-1	2017	The reactions of Criegee intermediates with NO2 have been proposed as a potentially significant source of the important nighttime oxidant NO3, particularly in urban environments where concentrations of ozone, alkenes and NOx are high.	Nitrogen Dioxide	44-47	NBL1, DAN family BMP antagonist	Homo sapiens	138-141
28604897-4	2017	NO3 is not observed; however, temporally resolved and [NO2]-dependent signal is observed at the mass of the Criegee-NO2 adduct for both formaldehyde- and acetaldehyde-oxide systems, and the structure of this adduct is explored through ab initio calculations.	Nitrogen Dioxide	55-58	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
28604897-4	2017	NO3 is not observed; however, temporally resolved and [NO2]-dependent signal is observed at the mass of the Criegee-NO2 adduct for both formaldehyde- and acetaldehyde-oxide systems, and the structure of this adduct is explored through ab initio calculations.	Nitrogen Dioxide	116-119	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
28830189-7	2017	In the quarter century since this seminal work was published, almost nothing has been reported about nitrogen disulfide even though NS2 is isovalent with the common NO2.	Nitrogen Dioxide	165-168	NS2	Homo sapiens	132-135
29964965-10	2017	In lung tissue, PM10 exposure was significantly associated with decreased p 53 promoter methylation (r=-0.347, P=0.038) and NO2 exposure was significantly associated with decreased promoter methylation of p 53, MGMT, and MAGE-A 4 (r=-0.482, -0.444, and -0.346, respectively; P&lt; 0.05).	Nitrogen Dioxide	124-127	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	205-209
29964965-10	2017	In lung tissue, PM10 exposure was significantly associated with decreased p 53 promoter methylation (r=-0.347, P=0.038) and NO2 exposure was significantly associated with decreased promoter methylation of p 53, MGMT, and MAGE-A 4 (r=-0.482, -0.444, and -0.346, respectively; P&lt; 0.05).	Nitrogen Dioxide	124-127	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	211-215
29964965-10	2017	In lung tissue, PM10 exposure was significantly associated with decreased p 53 promoter methylation (r=-0.347, P=0.038) and NO2 exposure was significantly associated with decreased promoter methylation of p 53, MGMT, and MAGE-A 4 (r=-0.482, -0.444, and -0.346, respectively; P&lt; 0.05).	Nitrogen Dioxide	124-127	MAGE family member A4	Rattus norvegicus	221-229
28545656-5	2017	We investigated in 590 newborns the association between cord plasma insulin levels and exposure to particulate matter (PM2.5 and PM10) and nitrogen dioxide (NO2) in various exposure windows during pregnancy.	Nitrogen Dioxide	139-155	insulin	Homo sapiens	68-75
28545656-5	2017	We investigated in 590 newborns the association between cord plasma insulin levels and exposure to particulate matter (PM2.5 and PM10) and nitrogen dioxide (NO2) in various exposure windows during pregnancy.	Nitrogen Dioxide	157-160	insulin	Homo sapiens	68-75
28137791-2	2017	The objective of this study was to determine whether exposure to elevated concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameter &lt;2.5 (PM2.5) had adverse effects on longitudinal measures of insulin sensitivity (SI), beta-cell function, and obesity in children at high risk for developing diabetes.	Nitrogen Dioxide	92-108	insulin	Homo sapiens	228-235
28137791-2	2017	The objective of this study was to determine whether exposure to elevated concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameter &lt;2.5 (PM2.5) had adverse effects on longitudinal measures of insulin sensitivity (SI), beta-cell function, and obesity in children at high risk for developing diabetes.	Nitrogen Dioxide	110-113	insulin	Homo sapiens	228-235
28669936-7	2017	RESULTS: A 10 mug/m3 increase of NO2 exposure during infancy was associated with a 13.6% (95% confidence interval (CI): 0.8; 28.1%) increase in interleukin-6 (IL-6) levels, as well as with a 27.8% (95% CI: 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma.	Nitrogen Dioxide	33-36	interleukin 6	Homo sapiens	144-157
28333392-4	2017	We report that C. reinhardtii supplied with nitrite (NO2- ) under aerobic conditions can reduce NO2- into nitric oxide (NO) using either a mitochondrial cytochrome c oxidase (COX) or a dual enzymatic system of nitrate reductase (NR) and amidoxime-reducing component, and that NO is subsequently reduced into N2 O by the enzyme NO reductase (NOR).	Nitrogen Dioxide	53-56	uncharacterized protein	Chlamydomonas reinhardtii	210-227
28333392-4	2017	We report that C. reinhardtii supplied with nitrite (NO2- ) under aerobic conditions can reduce NO2- into nitric oxide (NO) using either a mitochondrial cytochrome c oxidase (COX) or a dual enzymatic system of nitrate reductase (NR) and amidoxime-reducing component, and that NO is subsequently reduced into N2 O by the enzyme NO reductase (NOR).	Nitrogen Dioxide	53-56	uncharacterized protein	Chlamydomonas reinhardtii	229-231
28319795-9	2017	The calculation results demonstrate that the substitution of COH and NO2 by fluorine in BDF-TT and BDP-TT leads to higher maximum theoretical efficiencies (eta).	Nitrogen Dioxide	69-72	endothelin receptor type A	Homo sapiens	156-159
28629119-4	2017	Overall, the adamantyl-based ester with the mono-substituent at position 3 of the phenyl ring exhibited good AChE inhibition effects with an ascending order for the substituents: Cl &lt; NO2 &lt; CH3 &lt; OCH3.	Nitrogen Dioxide	187-190	acetylcholinesterase (Cartwright blood group)	Homo sapiens	109-113
28629119-5	2017	Furthermore, compounds with electron-withdrawing groups (Cl and NO2) substituted at position 3 on their phenyl rings demonstrated stronger AChE inhibition effects, in comparison to their respective positional isomers.	Nitrogen Dioxide	64-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	139-143
28617311-1	2017	This study aimed to investigate whether the -1026(A&gt;C)(rs2779249) and +2087(A&gt;G)(2297518) polymorphisms in the NOS2 gene were associated with chronic periodontitis (CP) and with salivary levels of nitrite (NO2-) and/or nitrate + nitrite (NOx).	Nitrogen Dioxide	212-215	nitric oxide synthase 2	Homo sapiens	117-121
28669936-7	2017	RESULTS: A 10 mug/m3 increase of NO2 exposure during infancy was associated with a 13.6% (95% confidence interval (CI): 0.8; 28.1%) increase in interleukin-6 (IL-6) levels, as well as with a 27.8% (95% CI: 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma.	Nitrogen Dioxide	33-36	interleukin 6	Homo sapiens	159-163
28669936-7	2017	RESULTS: A 10 mug/m3 increase of NO2 exposure during infancy was associated with a 13.6% (95% confidence interval (CI): 0.8; 28.1%) increase in interleukin-6 (IL-6) levels, as well as with a 27.8% (95% CI: 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma.	Nitrogen Dioxide	33-36	interleukin 10	Homo sapiens	230-235
28409432-5	2017	Relative risks (RRs) and their 95% confidence intervals (CIs) associated with a 10 mug/m3 increase were 1.14 (1.04~1.26) on lag1 for PM10, 1.31 (1.21~1.51) on lag01 for SO2, and 1.96 (1.49~2.57) on lag02 for NO2 on dust days.	Nitrogen Dioxide	208-211	ceramide synthase 1	Homo sapiens	124-128
28202267-3	2017	Comparison of the LES results from two chemical schemes (simple NOx-O3 chemistry and a more comprehensive Reduced Chemical Scheme (RCS) chemical mechanism) shows that the concentrations of NO2 and Ox inside the street canyon are enhanced by approximately 30-40% via OH/HO2 chemistry.	Nitrogen Dioxide	189-192	heme oxygenase 2	Homo sapiens	269-272
28426211-2	2017	This study tries to expand the ground measurements of NO3- concentrations at monitoring sites to a national scale, based on the Ozone Monitoring Instrument (OMI) NO2 columns, NO2 profiles from an atmospheric chemistry transport model (Model for Ozone and Related chemical Tracers, version 4, MOZART-4) and monitor-based sources, and then estimates the NO3- depositions on a regional scale based on an inferred model.	Nitrogen Dioxide	162-165	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
28481326-0	2017	The Dose-Response Association between Nitrogen Dioxide Exposure and Serum Interleukin-6 Concentrations.	Nitrogen Dioxide	38-54	interleukin 6	Homo sapiens	74-87
28481326-6	2017	We found a positive association with increasing serum IL-6 concentration (geometric mean 1.20 (95% CI: 1.1 to 1.3, p = 0.001) per quartile increase in NO2).	Nitrogen Dioxide	151-154	interleukin 6	Homo sapiens	54-58
28481326-8	2017	However, there was some evidence consistent with serum IL-6 being on the causal pathway between NO2 and cardiovascular risk.	Nitrogen Dioxide	96-99	interleukin 6	Homo sapiens	55-59
28382338-1	2017	Using first-principle atomistic simulations, we focused on the electronic structures of small gas molecules (CO, H2O, NH3, NO, and NO2) adsorbed on the S-vacancy SnS2 monolayer.	Nitrogen Dioxide	131-134	sodium voltage-gated channel alpha subunit 11	Homo sapiens	162-166
28198914-19	2017	There was a reduction in NO2/NO3 (mmol/L) levels in the TAA+Vit.E group (31.47+-4.26 in 24 hours and 38.93+-5.20 in 48 hours) compared to the TAA group (49.37+-5.12 in 24 hours and 53.53+-5.97 in 48 hours).	Nitrogen Dioxide	25-28	vitrin	Rattus norvegicus	60-63
28340298-1	2017	Photolysis of nitrate (NO3-) produces reactive nitrogen and oxygen species via three different channels, forming: (1) nitrogen dioxide (NO2) and hydroxyl radical ( OH), (2) nitrite (NO2-) and oxygen atom (O(3P)), and (3) peroxynitrite (ONOO-).	Nitrogen Dioxide	118-134	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
28340298-1	2017	Photolysis of nitrate (NO3-) produces reactive nitrogen and oxygen species via three different channels, forming: (1) nitrogen dioxide (NO2) and hydroxyl radical ( OH), (2) nitrite (NO2-) and oxygen atom (O(3P)), and (3) peroxynitrite (ONOO-).	Nitrogen Dioxide	136-139	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
28340298-1	2017	Photolysis of nitrate (NO3-) produces reactive nitrogen and oxygen species via three different channels, forming: (1) nitrogen dioxide (NO2) and hydroxyl radical ( OH), (2) nitrite (NO2-) and oxygen atom (O(3P)), and (3) peroxynitrite (ONOO-).	Nitrogen Dioxide	182-185	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
28323554-1	2017	Treatment of isolated Arabidopsis thaliana thylakoid membranes with nitrogen dioxide (NO2) induces selective nitration of the tyrosine residue at the ninth amino acid (9Tyr) of PsbO1.	Nitrogen Dioxide	68-84	PS II oxygen-evolving complex 1	Arabidopsis thaliana	177-182
28323554-1	2017	Treatment of isolated Arabidopsis thaliana thylakoid membranes with nitrogen dioxide (NO2) induces selective nitration of the tyrosine residue at the ninth amino acid (9Tyr) of PsbO1.	Nitrogen Dioxide	86-89	PS II oxygen-evolving complex 1	Arabidopsis thaliana	177-182
28315300-7	2017	GAPDH also inhibited heme-H2O2-NO2- induced protein carbonylation.	Nitrogen Dioxide	31-34	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-5
28101902-2	2017	The molecular formula of H3 CNO3 includes functional groups of CH3 , OH, NH2 , COOH, NO, NO2 , and NO3 , which are very important in connection with amino acids and NOx.	Nitrogen Dioxide	89-92	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
29965131-16	2017	SO42- had negative correlation with SO2, and NO3- had positive correlation with NO2.	Nitrogen Dioxide	80-83	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
28321449-8	2017	Remarkably, 3DOM Pt@CeO2-delta-rich/Ce1-xZrxO2 catalysts show super catalytic performance and strongly nanostructure-dependent activity for soot oxidation in the absence of NO and NO2.	Nitrogen Dioxide	180-183	carboxylesterase 1	Homo sapiens	36-39
28153714-2	2017	A significant source of NO is dietary nitrate (NO3), which is initially metabolized by oral bacteria into nitrite (NO2-) and is subsequently converted into NO once digested in the acidic gastric environment.	Nitrogen Dioxide	115-118	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
27142357-7	2017	There was a significant association between lung function (forced expiratory volume in 1 second intraday variability) and NO2 and NO among participants carrying the CD14 CT/TT genotype for lags 1, 2, and the 5-day average.	Nitrogen Dioxide	122-125	CD14 molecule	Homo sapiens	165-169
28287492-2	2017	Through modulating the operating temperature and the processing response signal with a pattern recognition algorithm, a gas sensor consisting of a single sensing electrode, i.e., ZnO/In2O3 composite, is designed to differentiate NO2, NH3, C3H6, CO within the level of 50-400 ppm.	Nitrogen Dioxide	229-232	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	120-123
28220917-5	2017	Spectrophotometric titrations performed for the [CuL3(OSMe2)]2+ complex indicate that this system is able to bind a wide range of anions with an affinity sequence: MeCO2- &gt; Cl- &gt; H2PO4- &gt; Br- &gt; NO2- &gt; HSO4- &gt; NO3-.	Nitrogen Dioxide	206-209	cullin 3	Homo sapiens	49-53
27142357-9	2017	While there was no association with any respiratory phenotype (as determined by symptoms), the CD14 CT/TT genotype appeared to be protective to increased exposure to NO2 and NO.	Nitrogen Dioxide	166-169	CD14 molecule	Homo sapiens	95-99
27986860-2	2017	In this study, we measured ONO-2952 brain TSPO occupancy in conscious rhesus monkeys using positron emission tomography (PET) with 11C-PBR28 as ligand for translational research to clinical application.	Nitrogen Dioxide	27-30	translocator protein	Macaca mulatta	42-46
28511369-8	2017	RESULTS: The study showed decreased NOx (Mono nitrogen oxide No and No2) levels in PIH as compared to control (p&lt; 0.001).	Nitrogen Dioxide	68-71	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	83-86
28572905-2	2017	Second-order rate constants (k) were determined from pseudo first-order and stoichiometric experiments, and follow the trends CF3 &lt; NO2 &lt; Cl &lt; H &lt; Me &lt; OMe &lt; NMe2 and LCuOH &lt; NO2 LCuOH.	Nitrogen Dioxide	135-138	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	176-180
28178345-0	2017	PI3Kdelta inhibitor idelalisib in combination with BTK inhibitor ONO/GS-4059 in diffuse large B cell lymphoma with acquired resistance to PI3Kdelta and BTK inhibitors.	Nitrogen Dioxide	65-68	Bruton tyrosine kinase	Homo sapiens	51-54
27684575-0	2017	Anti-tumor efficacy study of the Bruton"s tyrosine kinase (BTK) inhibitor, ONO/GS-4059, in combination with the glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab (GA101) demonstrates superior in vivo efficacy compared to ONO/GS-4059 in combination with rituximab.	Nitrogen Dioxide	75-78	Bruton tyrosine kinase	Homo sapiens	59-62
27684575-3	2017	Given the high potency and selectivity of the BTK inhibitor, ONO/GS-4059, it was hypothesized that, the anti-tumor activity of ONO/GS-4059 could be further enhanced by combining it with the anti-CD20 Abs, rituximab (RTX) or obinutuzumab (GA101).	Nitrogen Dioxide	61-64	Bruton tyrosine kinase	Homo sapiens	46-49
27684575-3	2017	Given the high potency and selectivity of the BTK inhibitor, ONO/GS-4059, it was hypothesized that, the anti-tumor activity of ONO/GS-4059 could be further enhanced by combining it with the anti-CD20 Abs, rituximab (RTX) or obinutuzumab (GA101).	Nitrogen Dioxide	61-64	keratin 20	Homo sapiens	195-199
27684575-3	2017	Given the high potency and selectivity of the BTK inhibitor, ONO/GS-4059, it was hypothesized that, the anti-tumor activity of ONO/GS-4059 could be further enhanced by combining it with the anti-CD20 Abs, rituximab (RTX) or obinutuzumab (GA101).	Nitrogen Dioxide	127-130	Bruton tyrosine kinase	Homo sapiens	46-49
27684575-3	2017	Given the high potency and selectivity of the BTK inhibitor, ONO/GS-4059, it was hypothesized that, the anti-tumor activity of ONO/GS-4059 could be further enhanced by combining it with the anti-CD20 Abs, rituximab (RTX) or obinutuzumab (GA101).	Nitrogen Dioxide	127-130	keratin 20	Homo sapiens	195-199
28017872-16	2017	Furthermore, the reduction of NO2- to NO via xanthine oxidoreductase during hypoxia appears to inhibit HIF-1alpha-mediated EV production.	Nitrogen Dioxide	30-33	xanthine dehydrogenase	Homo sapiens	45-68
28017872-16	2017	Furthermore, the reduction of NO2- to NO via xanthine oxidoreductase during hypoxia appears to inhibit HIF-1alpha-mediated EV production.	Nitrogen Dioxide	30-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
29688654-0	2017	Dependence of the Nitrogen Dioxide (NO2) Sensitivity of SnO(x) -Sn/Graphene Gas Sensors on Vacuum Annealing and Ultraviolet (UV) Ozone Exposure.	Nitrogen Dioxide	18-34	strawberry notch homolog 2	Homo sapiens	56-59
27564008-5	2017	An increase in PM2.5 of 10 ug/m3 was associated with a 2.5% (95% CI: 1.6-3.4%) increased risk of COPD-related ED and HA, an increase of 10 ug/m3 in NO2 was associated with a 4.2% (2.5-6.0%) increase, and an increase of 10 ug/m3 in SO2 was associated with a 2.1% (0.7-3.5%) increase.	Nitrogen Dioxide	148-151	COPD	Homo sapiens	97-101
27564008-9	2017	Ambient outdoor concentrations of PM2.5, NO2, and SO2 were significantly and positively associated with both COPD-related morbidity and mortality.	Nitrogen Dioxide	41-44	COPD	Homo sapiens	109-113
29688654-0	2017	Dependence of the Nitrogen Dioxide (NO2) Sensitivity of SnO(x) -Sn/Graphene Gas Sensors on Vacuum Annealing and Ultraviolet (UV) Ozone Exposure.	Nitrogen Dioxide	36-39	strawberry notch homolog 2	Homo sapiens	56-59
29688654-1	2017	Tin oxides and tin (SnO(x) -Sn) compound films were thermally evaporated onto chemical vapor deposition (CVD)-grown graphene films to obtain improved nitrogen dioxide (NO2) gas sensitivity.	Nitrogen Dioxide	150-166	strawberry notch homolog 2	Homo sapiens	20-23
29688654-5	2017	The chemisorbed Sn on the graphene generated by O3 exposure was oxidized by highly reactive NO2, resulting in a p-type doping effect, which would lead to n- to p-type sensitivity transition when the hole concentration exceeded the initial electron concentration of the n-type SnO(x) -Sn compound films.	Nitrogen Dioxide	92-95	strawberry notch homolog 2	Homo sapiens	276-279
28075565-0	2017	Redox Couple Involving NOx in Aerobic Pd-Catalyzed Oxidation of sp3-C-H Bonds: Direct Evidence for Pd-NO3-/NO2- Interactions Involved in Oxidation and Reductive Elimination.	Nitrogen Dioxide	107-110	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
27836342-6	2017	Fireworks displays directly increased the concentrations of PM2.5 and many chemicals, especially K+, Cl-, K, Cl, S, Cu and Sr, and concentrations of NO3- and NH4+ ions peaked after the fireworks period in the three rural sites, indicating the influence of firecrackers on the secondary formation of the precursors of NO2.	Nitrogen Dioxide	317-320	NBL1, DAN family BMP antagonist	Homo sapiens	149-152
27923813-4	2017	Reactions followed reversible biphasic kinetics, consistent with the presence of two electrophilic centers in NO2-CLA located on the beta- and delta-carbons with respect to the nitro group.	Nitrogen Dioxide	110-113	selectin P ligand	Homo sapiens	114-117
27923813-12	2017	These results provide new insights into the chemical basis of NO2-CLA signaling actions.	Nitrogen Dioxide	62-65	selectin P ligand	Homo sapiens	66-69
28075565-12	2017	Measurements by in situ infrared spectroscopy show that N2O is formed in sp3-C-H acetoxylation reactions at 80  C. Studies confirm that cyclopalladated NO2 complexes are rapidly oxidized to the corresponding NO3 adducts on exposure to NO2(g).	Nitrogen Dioxide	152-155	NBL1, DAN family BMP antagonist	Homo sapiens	208-211
28075565-12	2017	Measurements by in situ infrared spectroscopy show that N2O is formed in sp3-C-H acetoxylation reactions at 80  C. Studies confirm that cyclopalladated NO2 complexes are rapidly oxidized to the corresponding NO3 adducts on exposure to NO2(g).	Nitrogen Dioxide	235-238	NBL1, DAN family BMP antagonist	Homo sapiens	208-211
27858190-9	2016	Importantly, the effect of OA-NO2 is accompanied by prevention of STAT3 activation and HIF-1alpha stabilization.	Nitrogen Dioxide	30-33	signal transducer and activator of transcription 3	Homo sapiens	66-71
27776353-0	2017	Bruton tyrosine kinase inhibitor ONO/GS-4059: from bench to bedside.	Nitrogen Dioxide	33-36	Bruton tyrosine kinase	Homo sapiens	0-22
27448387-7	2017	RESULTS: We found epigenome-wide significant associations [false discovery rate (FDR) p &lt; 0.05] between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28).	Nitrogen Dioxide	116-119	lon peptidase 1, mitochondrial	Homo sapiens	237-242
27448387-7	2017	RESULTS: We found epigenome-wide significant associations [false discovery rate (FDR) p &lt; 0.05] between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28).	Nitrogen Dioxide	116-119	3-hydroxyisobutyrate dehydrogenase	Homo sapiens	277-283
27448387-7	2017	RESULTS: We found epigenome-wide significant associations [false discovery rate (FDR) p &lt; 0.05] between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28).	Nitrogen Dioxide	116-119	solute carrier family 25 member 28	Homo sapiens	302-310
27448387-10	2017	NO2 exposure at the time of biosampling in childhood had a significant impact on CAT and TPO expression.	Nitrogen Dioxide	0-3	thyroid peroxidase	Homo sapiens	89-92
28478454-12	2017	The concentration of NO2/NO3 following incubation with VEGF was significantly higher than from untreated cells.	Nitrogen Dioxide	21-24	vascular endothelial growth factor A	Homo sapiens	55-59
27744007-3	2016	Therefore, this study tested the hypothesis that dietary NO3- supplementation would be less effective at increasing the circulating plasma nitrite concentration ([NO2-]) and lowering blood pressure in smokers (S) compared to non-smokers (NS).	Nitrogen Dioxide	163-166	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
27589821-5	2016	The average values of NOR and SOR were more than 0.1 in PM1.0, suggesting that secondary formation of SO42- and NO3- from the gas precursors SO2 and NO2 occurred in PM1.0.	Nitrogen Dioxide	149-152	NBL1, DAN family BMP antagonist	Homo sapiens	112-115
27533342-6	2016	Good linearity from 0.050 to 1.0 microg mL-1 for SO2 and from 0.010 to 1.0 microg mL-1 for NO2 were obtained (R2 &gt; 0.99) with limits of detection of 30 and 50 ng mL-1 for SO2 and NO2, respectively.	Nitrogen Dioxide	91-94	L1 cell adhesion molecule	Mus musculus	82-86
27533342-6	2016	Good linearity from 0.050 to 1.0 microg mL-1 for SO2 and from 0.010 to 1.0 microg mL-1 for NO2 were obtained (R2 &gt; 0.99) with limits of detection of 30 and 50 ng mL-1 for SO2 and NO2, respectively.	Nitrogen Dioxide	91-94	L1 cell adhesion molecule	Mus musculus	82-86
26964143-9	2016	The enhanced NO2 production by PPARbeta/delta-/- MSCs was due to the increased retention of NF-kappaB p65 subunit on the kappaB elements of the inducible nitric oxide synthase promoter resulting from PPARbeta/delta silencing.	Nitrogen Dioxide	13-16	peroxisome proliferator activated receptor delta	Homo sapiens	31-39
26964143-9	2016	The enhanced NO2 production by PPARbeta/delta-/- MSCs was due to the increased retention of NF-kappaB p65 subunit on the kappaB elements of the inducible nitric oxide synthase promoter resulting from PPARbeta/delta silencing.	Nitrogen Dioxide	13-16	nuclear factor kappa B subunit 1	Homo sapiens	92-101
26964143-9	2016	The enhanced NO2 production by PPARbeta/delta-/- MSCs was due to the increased retention of NF-kappaB p65 subunit on the kappaB elements of the inducible nitric oxide synthase promoter resulting from PPARbeta/delta silencing.	Nitrogen Dioxide	13-16	peroxisome proliferator activated receptor delta	Homo sapiens	200-208
27657817-0	2016	NO2 inhalation causes tauopathy by disturbing the insulin signaling pathway.	Nitrogen Dioxide	0-3	insulin	Homo sapiens	50-57
27657817-3	2016	Considering the fact that the insulin signaling pathway can be targeted by air pollutants and regulate tau function, this study focused on the role of insulin signaling in this NO2-induced tauopathy.	Nitrogen Dioxide	177-180	insulin	Homo sapiens	30-37
27657817-3	2016	Considering the fact that the insulin signaling pathway can be targeted by air pollutants and regulate tau function, this study focused on the role of insulin signaling in this NO2-induced tauopathy.	Nitrogen Dioxide	177-180	insulin	Homo sapiens	151-158
27657817-4	2016	Using a dynamic inhalation treatment, we demonstrated that exposure to NO2 induced a disruption of insulin signaling in skeletal muscle, liver, and brain, with associated p38 MAPK and/or JNK activation.	Nitrogen Dioxide	71-74	insulin	Homo sapiens	99-106
27657817-4	2016	Using a dynamic inhalation treatment, we demonstrated that exposure to NO2 induced a disruption of insulin signaling in skeletal muscle, liver, and brain, with associated p38 MAPK and/or JNK activation.	Nitrogen Dioxide	71-74	mitogen-activated protein kinase 8	Homo sapiens	187-190
27657817-6	2016	These findings provide new insight into the possible mechanisms involved in the etiopathogenesis of NO2-induced tauopathy, suggesting that the targeting of insulin signaling may be a promising therapeutic strategy to prevent this disease.	Nitrogen Dioxide	100-103	insulin	Homo sapiens	156-163
27232203-12	2016	Influenza virus, cold temperatures, and increased atmospheric NO2, CO, PM10, and SO2 (but decreased O3) concentrations were identified as potential contributors to the burden of COPD exacerbations in the community.	Nitrogen Dioxide	62-65	COPD	Homo sapiens	178-182
27858190-9	2016	Importantly, the effect of OA-NO2 is accompanied by prevention of STAT3 activation and HIF-1alpha stabilization.	Nitrogen Dioxide	30-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
27858190-10	2016	CONCLUSION: In summary, OA-NO2 eliminates the manifestation of hypoxia- and ADMA-mediated endothelial dysfunction in HPAEC via the STAT3/HIF-1alpha cascade.	Nitrogen Dioxide	27-30	signal transducer and activator of transcription 3	Homo sapiens	131-136
27858190-10	2016	CONCLUSION: In summary, OA-NO2 eliminates the manifestation of hypoxia- and ADMA-mediated endothelial dysfunction in HPAEC via the STAT3/HIF-1alpha cascade.	Nitrogen Dioxide	27-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-147
27593618-1	2016	BACKGROUND: Dietary inorganic nitrate (NO3-) and its reduced forms nitrite (NO2-) and nitric oxide (NO), respectively, are of critical importance for host defense in the oral cavity.	Nitrogen Dioxide	76-79	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
27901641-1	2016	PsbO1 is exclusively nitrated when isolated thylakoid membranes are incubated in a buffer bubbled with nitrogen dioxide (NO2) containing NO2 and nitrite.	Nitrogen Dioxide	103-119	PS II oxygen-evolving complex 1	Arabidopsis thaliana	0-5
27901641-1	2016	PsbO1 is exclusively nitrated when isolated thylakoid membranes are incubated in a buffer bubbled with nitrogen dioxide (NO2) containing NO2 and nitrite.	Nitrogen Dioxide	121-124	PS II oxygen-evolving complex 1	Arabidopsis thaliana	0-5
27901641-1	2016	PsbO1 is exclusively nitrated when isolated thylakoid membranes are incubated in a buffer bubbled with nitrogen dioxide (NO2) containing NO2 and nitrite.	Nitrogen Dioxide	137-140	PS II oxygen-evolving complex 1	Arabidopsis thaliana	0-5
27901641-6	2016	A nitration mechanism whereby nitratable tyrosine residues of PsbO1 are, prior to nitration, selectively photo-oxidized by photosynthetic electron transport to tyrosyl radicals to combine with NO2 to form 3-nitrotyrosine was hypothesized.	Nitrogen Dioxide	193-196	PS II oxygen-evolving complex 1	Arabidopsis thaliana	62-67
27593618-6	2016	RESULTS: Our results show that, in comparison to a placebo group, consumption of beetroot juice that contains 4000 mg/L NO3- results in elevated levels of salivary NO2-, nitrite NO3-, and NO.	Nitrogen Dioxide	164-167	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
27756407-10	2016	CONCLUSIONS: Despite living in an area with air pollution concentrations below current USEPA NAAQS, these COPD patients appeared to suffer increased risk of COPD exacerbation following short-term exposures to increased concentrations of SO2 and NO2.	Nitrogen Dioxide	245-248	COPD	Homo sapiens	106-110
27831576-0	2016	Ab initio thermodynamic study of the SnO2(110) surface in an O2 and NO environment: a fundamental understanding of the gas sensing mechanism for NO and NO2.	Nitrogen Dioxide	152-155	strawberry notch homolog 2	Homo sapiens	37-40
27582402-9	2016	High levels of ambient CO (lag 1, 2, and 3) and NO2 (lag 2 and 3) were associated with decreased ED visits for asthma.	Nitrogen Dioxide	48-51	granulysin	Homo sapiens	53-64
27640071-6	2016	The OR for PD in individuals with high NO2 exposure ( 75th percentile) and the AA genotype of IL1B rs16944 was 3.10 (95% CI=1.14-8.38) compared with individuals with lower NO2 exposure (<75th percentile) and the GG genotype.	Nitrogen Dioxide	172-175	interleukin 1 beta	Homo sapiens	94-98
27510308-1	2016	The PERCA (PEroxy Radical Chemical Amplification) technique, which is based on the catalytic conversion of ambient peroxy radicals (HO2 and RO2, where R stands for any organic chain) to a larger amount of nitrogen dioxide (NO2) amplified by chain reactions by adding high concentrations of NO and CO in the flow reactor, has been widely used for total peroxy radical RO2* (RO2* = HO2 + SigmaRO2) measurements.	Nitrogen Dioxide	205-221	heme oxygenase 2	Homo sapiens	132-135
27712072-8	2016	The different stereochemistries of the bidentate ligands NO2-, NO3-, and acetylacetonate (acac) around the thorium center have very similar stabilities.	Nitrogen Dioxide	57-62	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
27934300-4	2016	The electron-withdrawing NO2 substituent on the N^N ligand leads to a blue-shift of the 1pi,pi*/1ILCT absorption band, while the electron-donating NPh2 substituent causes a pronounced red-shift of this band.	Nitrogen Dioxide	25-28	neurexophilin 2	Homo sapiens	147-151
27934300-5	2016	The unsubstituted and NO2-substituted complexes (complexes 1 and 2, respectively) are moderately emissive at room temperature (RT) in solution as well as at 77 K in the glassy matrix, while the NPh2-substituted complex (3) is weakly emissive at RT, but the emission becomes much brighter at 77 K. Complexes 1 and 2 show very broad and strong triplet excited-state absorption from 460 to 800 nm with moderately long lifetimes, while complex 3 exhibits weak but broad absorption bands from 384 to 800 nm with a longer lifetime than those of 1 and 2.	Nitrogen Dioxide	22-25	neurexophilin 2	Homo sapiens	194-198
27812194-9	2016	In addition, higher concentration of NO2 at the time of admission were significantly associated with higher likelihoods of PTB-related hospital admission in HIV-infected patients when 1.5 weeks (OR = 1.1; p = 0.044) and 2 weeks (OR = 1.21; p&lt;0.001) were used as controls.	Nitrogen Dioxide	37-40	polypyrimidine tract binding protein 1	Homo sapiens	123-126
27812194-11	2016	In conclusion, our data suggest an apparent seasonal variation in hospital admissions of HIV-infected patients with a PTB diagnosis (summer/autumn vs. winter/spring), as well as a link to short-term exposure to environmental risk factors, such as temperature and ambient NO2 and SO2.	Nitrogen Dioxide	271-274	polypyrimidine tract binding protein 1	Homo sapiens	118-121
27605624-7	2016	Nitrogen dioxide was associated with HOMA-IR, glucose, insulin, and leptin.	Nitrogen Dioxide	0-16	insulin	Homo sapiens	55-62
27510308-1	2016	The PERCA (PEroxy Radical Chemical Amplification) technique, which is based on the catalytic conversion of ambient peroxy radicals (HO2 and RO2, where R stands for any organic chain) to a larger amount of nitrogen dioxide (NO2) amplified by chain reactions by adding high concentrations of NO and CO in the flow reactor, has been widely used for total peroxy radical RO2* (RO2* = HO2 + SigmaRO2) measurements.	Nitrogen Dioxide	205-221	heme oxygenase 2	Homo sapiens	380-383
27510308-1	2016	The PERCA (PEroxy Radical Chemical Amplification) technique, which is based on the catalytic conversion of ambient peroxy radicals (HO2 and RO2, where R stands for any organic chain) to a larger amount of nitrogen dioxide (NO2) amplified by chain reactions by adding high concentrations of NO and CO in the flow reactor, has been widely used for total peroxy radical RO2* (RO2* = HO2 + SigmaRO2) measurements.	Nitrogen Dioxide	223-226	heme oxygenase 2	Homo sapiens	380-383
27668965-9	2016	For example, in vitro product studies revealed that phenylalanine, which is inert not only to oxidants produced through biochemical processes, but also to NO2  or O3 in isolation, is damaged by NO3 .	Nitrogen Dioxide	155-158	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
27668965-10	2016	The reaction is initiated by oxidation of the aromatic ring and, depending on the availability of NO2 , leads to formation of nitrophenylalanine or beta-nitrooxyphenylalanine, which could serve as marker for NO3 -induced oxidative damage in peptides.	Nitrogen Dioxide	98-101	NBL1, DAN family BMP antagonist	Homo sapiens	208-211
27668965-22	2016	2009, 113, 7977-7981), who showed that anions in the airway surfaces fluids mediate NO2  absorption by catalyzing its hydrolytic disproportionation into NO2-/HNO2 and NO3-.	Nitrogen Dioxide	84-87	NBL1, DAN family BMP antagonist	Homo sapiens	167-170
27756407-10	2016	CONCLUSIONS: Despite living in an area with air pollution concentrations below current USEPA NAAQS, these COPD patients appeared to suffer increased risk of COPD exacerbation following short-term exposures to increased concentrations of SO2 and NO2.	Nitrogen Dioxide	245-248	COPD	Homo sapiens	157-161
27349566-2	2016	rs1800566 polymorphism of NQO1, leading to P187S missense mutation in the transcribed antioxidant protein, causes individuals carrying this mutation more prone to NO2 induced lung inflammatory injury.	Nitrogen Dioxide	163-166	NAD(P)H quinone dehydrogenase 1	Homo sapiens	26-30
27593390-5	2016	NO2 affords [(TAML)Fe(III) (NO3 )](2-) , whereas electron transfer from Mn(IV) (O) to (.)	Nitrogen Dioxide	0-3	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
27631457-3	2016	We have synthesized and characterized gas-phase AnO3(NO3)2- complexes for An = U, Np, and Pu by endothermic NO2 elimination from AnO2(NO3)3-.	Nitrogen Dioxide	108-111	anoctamin 3	Homo sapiens	48-52
27631457-3	2016	We have synthesized and characterized gas-phase AnO3(NO3)2- complexes for An = U, Np, and Pu by endothermic NO2 elimination from AnO2(NO3)3-.	Nitrogen Dioxide	108-111	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
27631457-3	2016	We have synthesized and characterized gas-phase AnO3(NO3)2- complexes for An = U, Np, and Pu by endothermic NO2 elimination from AnO2(NO3)3-.	Nitrogen Dioxide	108-111	anoctamin 2	Homo sapiens	129-133
27631457-3	2016	We have synthesized and characterized gas-phase AnO3(NO3)2- complexes for An = U, Np, and Pu by endothermic NO2 elimination from AnO2(NO3)3-.	Nitrogen Dioxide	108-111	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
27631457-6	2016	This interpretation is substantiated by reactivity of the three complexes: NO2 spontaneously adds to UO3(NO3)2- and PuO3(NO3)2- but not to NpO3(NO3)2-.	Nitrogen Dioxide	75-78	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
27631457-6	2016	This interpretation is substantiated by reactivity of the three complexes: NO2 spontaneously adds to UO3(NO3)2- and PuO3(NO3)2- but not to NpO3(NO3)2-.	Nitrogen Dioxide	75-78	NBL1, DAN family BMP antagonist	Homo sapiens	121-124
27631457-6	2016	This interpretation is substantiated by reactivity of the three complexes: NO2 spontaneously adds to UO3(NO3)2- and PuO3(NO3)2- but not to NpO3(NO3)2-.	Nitrogen Dioxide	75-78	NBL1, DAN family BMP antagonist	Homo sapiens	121-124
27483336-1	2016	OBJECTIVES: We aimed to determine whether average and trimester-specific exposures to ambient measures of nitrogen dioxide (NO2) and particular matter (PM2.5) were associated with elevated cord blood concentrations of immunoglobulin E (IgE) and two epithelial cell produced cytokines: interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP).	Nitrogen Dioxide	106-122	immunoglobulin heavy constant epsilon	Homo sapiens	218-240
27483336-1	2016	OBJECTIVES: We aimed to determine whether average and trimester-specific exposures to ambient measures of nitrogen dioxide (NO2) and particular matter (PM2.5) were associated with elevated cord blood concentrations of immunoglobulin E (IgE) and two epithelial cell produced cytokines: interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP).	Nitrogen Dioxide	124-127	immunoglobulin heavy constant epsilon	Homo sapiens	218-240
27483336-5	2016	RESULTS: We observed statistically significant associations between maternal NO2 exposure and elevated cord blood concentrations of both IL-33 and TSLP among girls but not boys.	Nitrogen Dioxide	77-80	interleukin 33	Homo sapiens	137-142
27483336-5	2016	RESULTS: We observed statistically significant associations between maternal NO2 exposure and elevated cord blood concentrations of both IL-33 and TSLP among girls but not boys.	Nitrogen Dioxide	77-80	thymic stromal lymphopoietin	Homo sapiens	147-151
27585373-2	2016	The complex is assumed to decompose into [MnO(NO3)2](-) by elimination of NO2( ).	Nitrogen Dioxide	74-77	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
27585373-3	2016	The [MnO(NO3)2](-) product undergoes elimination of NO2( ) to yield [MnO2(NO3)](-), or elimination of NO( ) to yield [MnO3(NO3)](-).	Nitrogen Dioxide	52-55	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
27585373-3	2016	The [MnO(NO3)2](-) product undergoes elimination of NO2( ) to yield [MnO2(NO3)](-), or elimination of NO( ) to yield [MnO3(NO3)](-).	Nitrogen Dioxide	52-55	NBL1, DAN family BMP antagonist	Homo sapiens	74-77
27585373-3	2016	The [MnO(NO3)2](-) product undergoes elimination of NO2( ) to yield [MnO2(NO3)](-), or elimination of NO( ) to yield [MnO3(NO3)](-).	Nitrogen Dioxide	52-55	NBL1, DAN family BMP antagonist	Homo sapiens	74-77
27465529-0	2016	Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism.	Nitrogen Dioxide	17-33	urate oxidase	Mus musculus	0-7
27530289-3	2016	Replacement of -NO2 at C5 with other functional groups reduce the inhibitory activity in separase enzymatic assay.	Nitrogen Dioxide	15-19	extra spindle pole bodies like 1, separase	Homo sapiens	89-97
30090456-0	2016	MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO2, NO2 and PM2.5 co-exposure through targeting the HIF-1alpha/Fhl-1 pathway.	Nitrogen Dioxide	78-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136
30090456-0	2016	MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO2, NO2 and PM2.5 co-exposure through targeting the HIF-1alpha/Fhl-1 pathway.	Nitrogen Dioxide	78-81	four and a half LIM domains 1	Homo sapiens	137-142
27465529-0	2016	Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism.	Nitrogen Dioxide	17-33	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	77-86
27465529-3	2016	We found that uric acid was increased in the airways of mice exposed to NO2 and that administration of uricase inhibited the development of OVA-driven allergic airway disease subsequent to OVA challenge, as well as the generation of OVA-specific Abs.	Nitrogen Dioxide	72-75	urate oxidase	Mus musculus	103-110
27465529-6	2016	Although blocking uric acid formation by allopurinol did not affect outcomes, administration of ultra-clean human serum albumin at protein concentrations equivalent to that of uricase inhibited NO2-promoted allergic airway disease.	Nitrogen Dioxide	194-197	urate oxidase	Mus musculus	176-183
27465529-7	2016	These results indicate that, although uric acid levels are elevated in the airways of NO2-exposed mice, the powerful inhibitory effect of uricase administration on allergic sensitization is mediated more through Ag-specific immune deviation than via suppression of allergic sensitization, a mechanism to be considered in the interpretation of results from other experimental systems.	Nitrogen Dioxide	86-89	urate oxidase	Mus musculus	138-145
29964710-5	2016	During the fog and haze process, the concentrations of NO2, CO, PM10 and PM2.5 were high and the levels of SO2 and O3 were low.	Nitrogen Dioxide	55-58	zinc finger protein, FOG family member 1	Homo sapiens	11-14
27529478-10	2016	In addition, the number of Ttf-1-positive cells and the capillary density were &gt;=1.5 times greater in the CDH+ONO group than in the CDH group, and this increase was associated with higher expression of vascular endothelial growth factor and stromal cell-derived factor in the CDH+ONO group, suggesting enhanced development of the alveolar and capillary networks.	Nitrogen Dioxide	113-116	transcription termination factor 1	Rattus norvegicus	27-32
27529478-10	2016	In addition, the number of Ttf-1-positive cells and the capillary density were &gt;=1.5 times greater in the CDH+ONO group than in the CDH group, and this increase was associated with higher expression of vascular endothelial growth factor and stromal cell-derived factor in the CDH+ONO group, suggesting enhanced development of the alveolar and capillary networks.	Nitrogen Dioxide	283-286	transcription termination factor 1	Rattus norvegicus	27-32
27310767-2	2016	The conjugate (NO2)L releases a fluorescent product upon reaction by Cys-SeH in aqueous PBS buffer by exhibiting a ~210-fold fluorescence enhancement even in the presence of 20 other amino acids with a minimum detection limit of (1.5 +- 0.2) x 10(-7) M. The selectivity of the Cys-SeH to (NO2)L was further proven by extending the fluorescence study to different other selenium compounds.	Nitrogen Dioxide	15-18	epoxide hydrolase 2	Homo sapiens	73-76
27310767-2	2016	The conjugate (NO2)L releases a fluorescent product upon reaction by Cys-SeH in aqueous PBS buffer by exhibiting a ~210-fold fluorescence enhancement even in the presence of 20 other amino acids with a minimum detection limit of (1.5 +- 0.2) x 10(-7) M. The selectivity of the Cys-SeH to (NO2)L was further proven by extending the fluorescence study to different other selenium compounds.	Nitrogen Dioxide	15-18	epoxide hydrolase 2	Homo sapiens	281-284
27310767-3	2016	The role of para-nitrobenzenesulfonyl (pNBS) center in (NO2)L in the selective recognition of Cys-SeH was confirmed when the fluorescence emission studies were carried out using five different derivatizations possessing two NO2, five fluoro, two fluoro, one fluoro, and no fluoro groups.	Nitrogen Dioxide	56-59	epoxide hydrolase 2	Homo sapiens	98-101
27310767-5	2016	The application potential of (NO2)L has been demonstrated by studying its selectivity toward Cys-SeH in aqueous PBS buffer, in bovine serum, and on the silica gel surface that lead to minimum detection limits of (25 +- 2), (80 +- 5), and (168 +- 16) ppb, respectively.	Nitrogen Dioxide	30-33	epoxide hydrolase 2	Homo sapiens	97-100
27310767-7	2016	Thus, (NO2)L is aqueous soluble and a biologically acceptable probe for Cys-SeH.	Nitrogen Dioxide	7-10	epoxide hydrolase 2	Homo sapiens	76-79
27729721-8	2016	Photo-regulation of transcript abundance of UPM1 and SIRB involved in the biosynthesis of siroheme the cofactor involved in 6 electron reduction of NO2- and SO32- by NiR and SiR is crucial as the gene expression of latter two enzymes along with other N and S assimilatory enzymes are also modulated by light.	Nitrogen Dioxide	148-151	urophorphyrin methylase 1	Arabidopsis thaliana	44-48
27131407-3	2016	The aim of this study was to assess whether oral intake of a nitrate (NO3-)-rich dietary supplement (amaranth extract) is able to increase NO3- and nitrite (NO2-) levels in blood plasma and saliva of healthy adults.	Nitrogen Dioxide	157-160	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
27131407-5	2016	The NO3- and NO2- levels in plasma as well as saliva were measured up to 24 h. RESULTS: After administration of amaranth extract, the NO3- levels in plasma as well as saliva were found to be significantly (P &lt; 0.001) higher than in the placebo group.	Nitrogen Dioxide	13-16	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
27117015-4	2016	The observations in the vicinity of main roads in German cities show a decrease in the ratio of OH reactivities of VOC and NO2 (RVOC/RNO2) by a factor of 7.5 over the time period 1994-2014.	Nitrogen Dioxide	123-126	NLR family pyrin domain containing 12	Homo sapiens	133-137
27317054-9	2016	The PC3 contained high loadings for NO2 (2-) and NO3 (-).	Nitrogen Dioxide	36-39	chromobox 8	Homo sapiens	4-7
27206323-8	2016	NO2 elicited the greatest HMOX1 response, whereas O3 more greatly induced IL-6, IL-8 and PTGS2 expression.	Nitrogen Dioxide	0-3	heme oxygenase 1	Homo sapiens	26-31
27729721-8	2016	Photo-regulation of transcript abundance of UPM1 and SIRB involved in the biosynthesis of siroheme the cofactor involved in 6 electron reduction of NO2- and SO32- by NiR and SiR is crucial as the gene expression of latter two enzymes along with other N and S assimilatory enzymes are also modulated by light.	Nitrogen Dioxide	148-151	sirohydrochlorin ferrochelatase B	Arabidopsis thaliana	53-57
27171587-3	2016	For neat, neutral pH LiNO3 solutions (7 mol dm(-3)), NO3( ) produced by the pulse is fully consumed within 160 mus by OH( ) (37%), H2O (29%), NO2(-) (17%), and NO2 (17%).	Nitrogen Dioxide	142-145	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
27171587-3	2016	For neat, neutral pH LiNO3 solutions (7 mol dm(-3)), NO3( ) produced by the pulse is fully consumed within 160 mus by OH( ) (37%), H2O (29%), NO2(-) (17%), and NO2 (17%).	Nitrogen Dioxide	160-163	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
27171587-4	2016	For acidic HNO3 solutions (7 mol dm(-3)), radiolytically produced NO3( ) is predominantly consumed within 1 ms by HNO2 (15%) and NO2 (80%).	Nitrogen Dioxide	115-118	NBL1, DAN family BMP antagonist	Homo sapiens	12-15
27012417-5	2016	Herein we demonstrate that nitro-arachidonic acid (NO2-AA) or nitro-oleic acid (NO2-OA) administrated to astrocytes expressing the ALS-linked hSOD1(G93A) induce antioxidant phase II enzyme expression through Nrf2 activation concomitant with increasing intracellular glutathione levels.	Nitrogen Dioxide	51-54	superoxide dismutase 1	Homo sapiens	142-147
27020551-4	2016	Here, we showed that exposure of SH-SY5Y cells to MPO (or HOCl) resulted in a significant loss in viability, ATP and glutathione levels, and treatment of neuronal cells with NO2(-) substantially attenuated MPO (or HOCl)-dependent cellular toxicity.	Nitrogen Dioxide	174-177	myeloperoxidase	Homo sapiens	50-53
27020551-4	2016	Here, we showed that exposure of SH-SY5Y cells to MPO (or HOCl) resulted in a significant loss in viability, ATP and glutathione levels, and treatment of neuronal cells with NO2(-) substantially attenuated MPO (or HOCl)-dependent cellular toxicity.	Nitrogen Dioxide	174-177	myeloperoxidase	Homo sapiens	206-209
27020551-5	2016	The protective effects of NO2(-) on MPO (or HOCl)-induced cytotoxicity were because that (1) NO2(-) at high concentrations competed effectively with Cl(-) for MPO, thus limiting OCl(-) production by the enzyme; (2) HOCl was removed by reacting with NO2(-), forming less damaging compound; (3) NO2(-) significantly inhibited MPO-mediated inactivation of brain protein (enolase) and protein oxidation.	Nitrogen Dioxide	26-29	myeloperoxidase	Homo sapiens	36-39
27020551-5	2016	The protective effects of NO2(-) on MPO (or HOCl)-induced cytotoxicity were because that (1) NO2(-) at high concentrations competed effectively with Cl(-) for MPO, thus limiting OCl(-) production by the enzyme; (2) HOCl was removed by reacting with NO2(-), forming less damaging compound; (3) NO2(-) significantly inhibited MPO-mediated inactivation of brain protein (enolase) and protein oxidation.	Nitrogen Dioxide	26-29	myeloperoxidase	Homo sapiens	159-162
27020551-5	2016	The protective effects of NO2(-) on MPO (or HOCl)-induced cytotoxicity were because that (1) NO2(-) at high concentrations competed effectively with Cl(-) for MPO, thus limiting OCl(-) production by the enzyme; (2) HOCl was removed by reacting with NO2(-), forming less damaging compound; (3) NO2(-) significantly inhibited MPO-mediated inactivation of brain protein (enolase) and protein oxidation.	Nitrogen Dioxide	26-29	myeloperoxidase	Homo sapiens	159-162
27020551-5	2016	The protective effects of NO2(-) on MPO (or HOCl)-induced cytotoxicity were because that (1) NO2(-) at high concentrations competed effectively with Cl(-) for MPO, thus limiting OCl(-) production by the enzyme; (2) HOCl was removed by reacting with NO2(-), forming less damaging compound; (3) NO2(-) significantly inhibited MPO-mediated inactivation of brain protein (enolase) and protein oxidation.	Nitrogen Dioxide	93-96	myeloperoxidase	Homo sapiens	36-39
27020551-5	2016	The protective effects of NO2(-) on MPO (or HOCl)-induced cytotoxicity were because that (1) NO2(-) at high concentrations competed effectively with Cl(-) for MPO, thus limiting OCl(-) production by the enzyme; (2) HOCl was removed by reacting with NO2(-), forming less damaging compound; (3) NO2(-) significantly inhibited MPO-mediated inactivation of brain protein (enolase) and protein oxidation.	Nitrogen Dioxide	93-96	myeloperoxidase	Homo sapiens	36-39
27020551-5	2016	The protective effects of NO2(-) on MPO (or HOCl)-induced cytotoxicity were because that (1) NO2(-) at high concentrations competed effectively with Cl(-) for MPO, thus limiting OCl(-) production by the enzyme; (2) HOCl was removed by reacting with NO2(-), forming less damaging compound; (3) NO2(-) significantly inhibited MPO-mediated inactivation of brain protein (enolase) and protein oxidation.	Nitrogen Dioxide	93-96	myeloperoxidase	Homo sapiens	36-39
27020551-6	2016	Therefore, NO2(-) could show novel protective effects in some neurodegenerative diseases by preventing MPO-mediated oxidative damage.	Nitrogen Dioxide	11-14	myeloperoxidase	Homo sapiens	103-106
27020551-3	2016	Since NO2(-) and MPO (and/or HOCl) were important mediators in brain function and disease, we investigated the effects of NO2(-) on MPO-mediated damage to human neuroblastoma SH-SY5Y cells.	Nitrogen Dioxide	122-125	myeloperoxidase	Homo sapiens	132-135
28328022-7	2016	RESULTS: It was found that Cd powder could be directly used to reduce NO3- to NO2- .	Nitrogen Dioxide	78-81	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
27195597-3	2016	We found that an increase of 10 mug/m(3) in particulate matter with an aerodynamic diameter of 10 mum or less (PM10), sulfur dioxide (SO2) and nitrogen dioxide (NO2) was associated with a 1.58% (95% confidence interval (CI): 0.12-3.06%), 3.45% (95% CI: 1.30-5.66%) and 2.35% (95% CI: 0.42-4.32%) increase of COPD mortality over a lag of 0-15 days, respectively.	Nitrogen Dioxide	161-164	COPD	Homo sapiens	308-312
27016566-5	2016	Compared to the initial RDX bulk delta(15)N value of +9%, delta(15)N values of the NO2 (-) released from RDX ranged from -7% to +2% during aerobic biodegradation and from -42% to -24% during anaerobic biodegradation.	Nitrogen Dioxide	83-86	radixin	Homo sapiens	105-108
27072136-1	2016	Here we discuss the removal of nitrogen dioxide, an important toxic industrial chemical and pollutant, from air using the MOF UiO-66-NH2 .	Nitrogen Dioxide	31-47	lysine acetyltransferase 8	Homo sapiens	122-125
27072136-2	2016	The amine group is found to substantially aid in the removal, resulting in unprecedented removal capacities upwards of 1.4 g of NO2  /g of MOF.	Nitrogen Dioxide	128-131	lysine acetyltransferase 8	Homo sapiens	139-142
27072136-4	2016	Of particular significance is the formation of a diazonium ion on the aromatic ring of the MOF, and the potential reduction of NO2 to molecular nitrogen.	Nitrogen Dioxide	127-130	lysine acetyltransferase 8	Homo sapiens	91-94
27146290-4	2016	The sensor molecule is a charge-transfer fluorophore, DCM, which is strongly fluorescent in its pristine state, but non-fluorescent after the quick reaction with NO2  (or NO2(+)) generated from the UV photolysis of RDX, HMX (or PETN).	Nitrogen Dioxide	162-165	radixin	Homo sapiens	215-218
27146290-4	2016	The sensor molecule is a charge-transfer fluorophore, DCM, which is strongly fluorescent in its pristine state, but non-fluorescent after the quick reaction with NO2  (or NO2(+)) generated from the UV photolysis of RDX, HMX (or PETN).	Nitrogen Dioxide	171-174	radixin	Homo sapiens	215-218
26841777-10	2016	We propose that aerobic methane oxidation coupled to denitrification and perchlorate reduction (AMO-D and AMO-PR) directly oxidized methane and reduced NO3 (-) to NO2 (-) or N2O under anoxic condition, producing organic matter for methanol-assimilating denitrification and perchlorate reduction (MA-D and MA-PR) to reduce NO3 (-).	Nitrogen Dioxide	163-166	NBL1, DAN family BMP antagonist	Homo sapiens	152-155
27026336-3	2016	We investigated the association between maternal exposure to nitrogen dioxide and fine particulate matter (aerodynamic diameter &lt;=2.5 microm) and umbilical cord blood leptin and adiponectin levels with mixed-effects linear regression models among 1,257 mother-infant pairs from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, conducted in Canada (2008-2011).	Nitrogen Dioxide	61-77	leptin	Homo sapiens	170-176
27026336-5	2016	We also observed 13% (95% confidence interval: 6, 20) higher adiponectin levels per interquartile-range increase in average exposure to nitrogen dioxide (13.6 parts per billion) during pregnancy.	Nitrogen Dioxide	136-152	adiponectin, C1Q and collagen domain containing	Homo sapiens	61-72
26841777-10	2016	We propose that aerobic methane oxidation coupled to denitrification and perchlorate reduction (AMO-D and AMO-PR) directly oxidized methane and reduced NO3 (-) to NO2 (-) or N2O under anoxic condition, producing organic matter for methanol-assimilating denitrification and perchlorate reduction (MA-D and MA-PR) to reduce NO3 (-).	Nitrogen Dioxide	163-166	NBL1, DAN family BMP antagonist	Homo sapiens	322-325
26575342-1	2016	NOx (NOx   NO + NO2) regulates O3 and HOx (HOx   OH + HO2) concentrations in the upper troposphere.	Nitrogen Dioxide	16-19	heme oxygenase 2	Homo sapiens	54-57
30090283-1	2016	Cytochrome cd1 is a key enzyme in bacterial denitrification and catalyzes one-electron reduction of nitrite (NO2-) to nitric oxide (NO) at the heme d1 center under anaerobic conditions.	Nitrogen Dioxide	109-112	CD1c molecule	Homo sapiens	11-14
27167545-7	2016	The PI in relative risk was 15% to PM10 in Lag 0 and 7% points in Lag 1 for NO2.	Nitrogen Dioxide	76-79	ceramide synthase 1	Homo sapiens	66-71
26575342-7	2016	The analysis indicates that HNO3 production from the HO2 and NO reaction (if any) must be accompanied by a slower rate for the reaction of OH with NO2, keeping the total combined rate for the two processes at the rate reported for HNO3 production above.	Nitrogen Dioxide	147-150	heme oxygenase 2	Homo sapiens	53-56
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Nitrogen Dioxide	142-145	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Nitrogen Dioxide	142-145	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Nitrogen Dioxide	142-145	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Nitrogen Dioxide	142-145	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Nitrogen Dioxide	142-145	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26814598-8	2016	Typical MS/MS fragmentation pattern of all NO2-PL included a neutral loss of HNO2, product ions arising from the combined loss of polar headgroup and HNO2, [NO2-FA + H](+) and [NO2-FA - H](-) product ions, and cleavages on the fatty acid backbone near the nitro group, allowing its localization within the FA akyl chain.	Nitrogen Dioxide	43-46	fumarylacetoacetate hydrolase	Homo sapiens	181-187
26854590-8	2016	Moreover, the reduced effect of NO2(-) on OCl(-) production was attributed to that NO2(-) reduced H2O2 production in activated neutrophils without influencing the release of myeloperoxidase (MPO), thus limiting OCl(-) production by MPO/H2O2 system.	Nitrogen Dioxide	32-35	myeloperoxidase	Homo sapiens	191-194
26854590-8	2016	Moreover, the reduced effect of NO2(-) on OCl(-) production was attributed to that NO2(-) reduced H2O2 production in activated neutrophils without influencing the release of myeloperoxidase (MPO), thus limiting OCl(-) production by MPO/H2O2 system.	Nitrogen Dioxide	32-35	myeloperoxidase	Homo sapiens	232-235
26854590-8	2016	Moreover, the reduced effect of NO2(-) on OCl(-) production was attributed to that NO2(-) reduced H2O2 production in activated neutrophils without influencing the release of myeloperoxidase (MPO), thus limiting OCl(-) production by MPO/H2O2 system.	Nitrogen Dioxide	83-86	myeloperoxidase	Homo sapiens	232-235
26928013-0	2016	NO2 inhalation promotes Alzheimer"s disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication.	Nitrogen Dioxide	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	62-78
26928013-0	2016	NO2 inhalation promotes Alzheimer"s disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication.	Nitrogen Dioxide	0-3	monoglyceride lipase	Mus musculus	119-142
26928013-5	2016	Furthermore, increasing endocannabinoid 2-arachidonoylglycerol (2-AG) by inhibiting monoacylglycerol lipase (MAGL) prevented PGE2 production, neuroinflammation-associated Abeta42 accumulation, and neurodegeneration, indicating a therapeutic target for relieving cognitive impairment caused by NO2 exposure.	Nitrogen Dioxide	293-296	monoglyceride lipase	Mus musculus	84-107
26928013-5	2016	Furthermore, increasing endocannabinoid 2-arachidonoylglycerol (2-AG) by inhibiting monoacylglycerol lipase (MAGL) prevented PGE2 production, neuroinflammation-associated Abeta42 accumulation, and neurodegeneration, indicating a therapeutic target for relieving cognitive impairment caused by NO2 exposure.	Nitrogen Dioxide	293-296	monoglyceride lipase	Mus musculus	109-113
26928013-3	2016	In this study, we exposed C57BL/6J and APP/PS1 mice to dynamic NO2 inhalation and found for the first time that NO2 inhalation caused deterioration of spatial learning and memory, aggravated amyloid beta42 (Abeta42) accumulation, and promoted pathological abnormalities and cognitive defects related to Alzheimer"s disease (AD).	Nitrogen Dioxide	112-115	presenilin 1	Mus musculus	43-46
26780415-9	2016	The results indicated that NO3(-)+NO2(-)-N flux was an important factor in denitrification of mudflat sediments in Ariake Bay.	Nitrogen Dioxide	34-37	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
26564204-8	2016	Additional experiments reveal NasT is required for NO3 (-)-responsive expression of the narK-bjgb-flp-nasC transcriptional unit and the nirA gene and that NasS is also involved in the regulatory control of this novel bipartite assimilatory NO3 (-)/NO2 (-) reductase pathway.	Nitrogen Dioxide	248-251	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
26610295-4	2016	In this work, we evaluated the potential of exogenous nitrate (NO3(-)) on relieving NO2(-) toxicity, putatively facilitated by NarK, a NO3(-)/NO2(-) transporter encoded in the anammox genome.	Nitrogen Dioxide	84-87	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
26610295-4	2016	In this work, we evaluated the potential of exogenous nitrate (NO3(-)) on relieving NO2(-) toxicity, putatively facilitated by NarK, a NO3(-)/NO2(-) transporter encoded in the anammox genome.	Nitrogen Dioxide	84-87	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
26610295-5	2016	The relative contribution of NO3(-) to NO2(-) detoxification was found to be pH dependent.	Nitrogen Dioxide	39-42	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
26610295-13	2016	We suggest that anammox cells can use a secondary transport system facilitated by exogenous NO3(-) to alleviate NO2(-) toxicity.	Nitrogen Dioxide	112-115	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
27872853-5	2016	ELISA showed that HA-CS-IL-1Ra microspheres inhibited IL-1beta-induced inflammation by attenuating increases in NO2- and prostaglandin E2 levels as well as increase in glycosaminoglycan release.	Nitrogen Dioxide	112-115	interleukin 1 receptor antagonist	Rattus norvegicus	24-30
26542378-0	2016	A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies.	Nitrogen Dioxide	56-59	Bruton tyrosine kinase	Homo sapiens	42-45
26542378-1	2016	We report the results of a multicenter phase 1 dose-escalation study of the selective Bruton tyrosine kinase (BTK) inhibitor ONO/GS-4059 in 90 patients with relapsed/refractory B-cell malignancies.	Nitrogen Dioxide	125-128	Bruton tyrosine kinase	Homo sapiens	86-108
26542378-1	2016	We report the results of a multicenter phase 1 dose-escalation study of the selective Bruton tyrosine kinase (BTK) inhibitor ONO/GS-4059 in 90 patients with relapsed/refractory B-cell malignancies.	Nitrogen Dioxide	125-128	Bruton tyrosine kinase	Homo sapiens	110-113
26631727-2	2016	NO3(-)/NO2(-) exerts a beneficial impact on NO homeostasis and its related cardiovascular functions.	Nitrogen Dioxide	7-10	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
26631727-3	2016	To visualize the physiological dynamics of NO3(-)/NO2(-) for assessing the precise roles of these anions, we developed a genetically encoded intermolecular fluorescence resonance energy transfer (FRET)-based indicator, named sNOOOpy (sensor for NO3(-)/NO2(-) in physiology), by employing NO3(-)/NO2(-)-induced dissociation of NasST involved in the denitrification system of rhizobia.	Nitrogen Dioxide	252-255	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
26631727-3	2016	To visualize the physiological dynamics of NO3(-)/NO2(-) for assessing the precise roles of these anions, we developed a genetically encoded intermolecular fluorescence resonance energy transfer (FRET)-based indicator, named sNOOOpy (sensor for NO3(-)/NO2(-) in physiology), by employing NO3(-)/NO2(-)-induced dissociation of NasST involved in the denitrification system of rhizobia.	Nitrogen Dioxide	252-255	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
26631727-4	2016	The in vitro use of sNOOOpy shows high specificity for NO3(-) and NO2(-), and its FRET signal is changed in response to NO3(-)/NO2(-) in the micromolar range.	Nitrogen Dioxide	66-69	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
26631727-4	2016	The in vitro use of sNOOOpy shows high specificity for NO3(-) and NO2(-), and its FRET signal is changed in response to NO3(-)/NO2(-) in the micromolar range.	Nitrogen Dioxide	66-69	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
26631727-4	2016	The in vitro use of sNOOOpy shows high specificity for NO3(-) and NO2(-), and its FRET signal is changed in response to NO3(-)/NO2(-) in the micromolar range.	Nitrogen Dioxide	127-130	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
26631727-4	2016	The in vitro use of sNOOOpy shows high specificity for NO3(-) and NO2(-), and its FRET signal is changed in response to NO3(-)/NO2(-) in the micromolar range.	Nitrogen Dioxide	127-130	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
26372737-4	2016	Especially, compounds AR-1 and AR-4, decorated with strong electron-withdrawing NO2 substituent, showed augmented anion sensing properties, being capable of naked-eye detecting of F(-) and AcO(-) when the water content is lower than 15%.	Nitrogen Dioxide	80-83	transcription factor 20	Homo sapiens	22-26
27872853-5	2016	ELISA showed that HA-CS-IL-1Ra microspheres inhibited IL-1beta-induced inflammation by attenuating increases in NO2- and prostaglandin E2 levels as well as increase in glycosaminoglycan release.	Nitrogen Dioxide	112-115	interleukin 1 beta	Rattus norvegicus	54-62
27820923-0	2016	The Proinflammatory Potential of Nitrogen Dioxide and Its Influence on the House Dust Mite Allergen Der p 1.	Nitrogen Dioxide	33-49	crystallin gamma F, pseudogene	Homo sapiens	104-107
26620549-5	2016	The goal of this study was to characterize the role of nitro-oleic acid (OA-NO2) in regulating the functional specialization of macrophages induced by bacterial lipopolysaccharide or interleukin-4, and to reveal specific signaling mechanisms which can account for OA-NO2-dependent modulation of inflammation and fibrotic responses.	Nitrogen Dioxide	76-79	interleukin 4	Homo sapiens	183-196
27820923-5	2016	NO2 exposure resulted in a concentration-dependent release of IL-6, but not IL-8 release.	Nitrogen Dioxide	0-3	interleukin 6	Homo sapiens	62-66
27820923-4	2016	Exposure to 0.1, 1 and 10 ppm NO2 or synthetic air as a control was performed for 1 h. Subsequently, the cells were exposed to Der p 1 for 24 h. The release of interleukin (IL)-6 and IL-8 was measured by ELISA, and the production of IL-6 mRNA and IL-8 mRNA was measured by RT-PCR.	Nitrogen Dioxide	30-33	interleukin 6	Homo sapiens	160-178
27820923-6	2016	The coexposure of 0.1 ppm NO2 and Der p 1, or 1 ppm NO2 and Der p 1 significantly increased both IL-6 and IL-8 release.	Nitrogen Dioxide	26-29	interleukin 6	Homo sapiens	97-101
27820923-6	2016	The coexposure of 0.1 ppm NO2 and Der p 1, or 1 ppm NO2 and Der p 1 significantly increased both IL-6 and IL-8 release.	Nitrogen Dioxide	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
26188109-7	2015	The estimated half maximal effective plasma concentrations (EC50) of ONO-5334 and confidence intervals were 1.79 (1.01 to 3.16) ng/mL for serum NTX, 2.07 (1.63 to 2.62) ng/mL for serum CTX, 1.85 (1.30 to 2.61) ng/mL for urinary NTX/creatinine, and 1.98 (0.94 to 3.76) ng/mL for urinary CTX/creatinine.	Nitrogen Dioxide	69-72	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	185-188
27820923-6	2016	The coexposure of 0.1 ppm NO2 and Der p 1, or 1 ppm NO2 and Der p 1 significantly increased both IL-6 and IL-8 release.	Nitrogen Dioxide	52-55	interleukin 6	Homo sapiens	97-101
27820923-6	2016	The coexposure of 0.1 ppm NO2 and Der p 1, or 1 ppm NO2 and Der p 1 significantly increased both IL-6 and IL-8 release.	Nitrogen Dioxide	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
27820923-8	2016	In conclusion, NO2 increases the release of inflammatory cytokines in human nasal epithelial cells, especially in coexposure with Der p 1, as a mechanism of allergotoxicology.	Nitrogen Dioxide	15-18	crystallin gamma F, pseudogene	Homo sapiens	134-137
26544504-1	2016	Globins, such as hemoglobin (Hb) and myoglobin (Mb), have gained attention for their ability to reduce nitrite (NO2(-)) to nitric oxide (NO).	Nitrogen Dioxide	112-115	myoglobin	Homo sapiens	37-46
26531150-3	2015	NO2 derivatives 8 show 5- to 10-fold higher GluN2B affinity than the unsubstituted ligands 7.	Nitrogen Dioxide	0-3	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	44-50
26188109-7	2015	The estimated half maximal effective plasma concentrations (EC50) of ONO-5334 and confidence intervals were 1.79 (1.01 to 3.16) ng/mL for serum NTX, 2.07 (1.63 to 2.62) ng/mL for serum CTX, 1.85 (1.30 to 2.61) ng/mL for urinary NTX/creatinine, and 1.98 (0.94 to 3.76) ng/mL for urinary CTX/creatinine.	Nitrogen Dioxide	69-72	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	286-289
26702974-4	2015	Similar to a previous study on NO2 uptake on mineral aerosols, the uptake coefficients are mainly on the order of 10(-6) for the Chinese dust, when BET areas are taken into account.	Nitrogen Dioxide	31-34	delta/notch like EGF repeat containing	Homo sapiens	148-151
26385079-7	2015	These data support that the dietary constituents NO3(-), NO2(-) and cLA promote the further generation of secondary electrophilic lipid products that are absorbed into the circulation at concentrations sufficient to exert systemic effects before being catabolized or excreted.	Nitrogen Dioxide	57-60	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
26332900-9	2015	The results indicate that both strong and weak antibacterial agents suppress the rise in plasma [NO2-] observed following the consumption of a high NO3- diet and the former can influence the BP response during low-intensity exercise.	Nitrogen Dioxide	97-100	NBL1, DAN family BMP antagonist	Homo sapiens	148-151
26153548-2	2015	Here, we showed that adiponectin upregulated inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) and protein expression in hepatic non-parenchymal cells, particularly in hepatic stellate cells (HSCs), and increased nitric oxide (NO2-/NO3-) concentration in HSC-conditioned medium.	Nitrogen Dioxide	237-240	adiponectin, C1Q and collagen domain containing	Mus musculus	21-32
26153548-2	2015	Here, we showed that adiponectin upregulated inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) and protein expression in hepatic non-parenchymal cells, particularly in hepatic stellate cells (HSCs), and increased nitric oxide (NO2-/NO3-) concentration in HSC-conditioned medium.	Nitrogen Dioxide	237-240	nitric oxide synthase 2, inducible	Mus musculus	45-76
26153548-2	2015	Here, we showed that adiponectin upregulated inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) and protein expression in hepatic non-parenchymal cells, particularly in hepatic stellate cells (HSCs), and increased nitric oxide (NO2-/NO3-) concentration in HSC-conditioned medium.	Nitrogen Dioxide	237-240	nitric oxide synthase 2, inducible	Mus musculus	78-82
26408817-6	2015	Docking studies revealed that the NO2 group of both compounds participate in interactions with Asp132 within the hCA IX active site, and with residues Lys67 and Asp130 in hCA XII, respectively.	Nitrogen Dioxide	34-37	carbonic anhydrase 12	Homo sapiens	171-178
26605044-2	2015	In this nitrogen removal process, a complete biological denitrification from nitrate (NO3 (-)) to molecular nitrogen (N2) was achieved by four reduction steps, forming nitrite (NO2 (-)), nitric oxide (NO) and nitrous oxide (N2O) as intermediate compounds.	Nitrogen Dioxide	177-180	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
26325324-1	2015	INTRODUCTION: Dietary nitrate (NO3-) supplementation serves as an exogenous source of nitrite (NO2-) and nitric oxide (NO) through the NO3- - NO2- - NO pathway, and may improve vascular functions during normoxia.	Nitrogen Dioxide	95-98	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
26325324-1	2015	INTRODUCTION: Dietary nitrate (NO3-) supplementation serves as an exogenous source of nitrite (NO2-) and nitric oxide (NO) through the NO3- - NO2- - NO pathway, and may improve vascular functions during normoxia.	Nitrogen Dioxide	95-98	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
26447741-0	2015	Physisorption-Based Charge Transfer in Two-Dimensional SnS2 for Selective and Reversible NO2 Gas Sensing.	Nitrogen Dioxide	89-92	sodium voltage-gated channel alpha subunit 11	Homo sapiens	55-59
26447741-4	2015	In this work, we present an important progress for selective and reversible NO2 sensing by demonstrating an economical sensing platform based on the charge transfer between physisorbed NO2 gas molecules and two-dimensional (2D) tin disulfide (SnS2) flakes at low operating temperatures.	Nitrogen Dioxide	76-79	sodium voltage-gated channel alpha subunit 11	Homo sapiens	243-247
26447741-4	2015	In this work, we present an important progress for selective and reversible NO2 sensing by demonstrating an economical sensing platform based on the charge transfer between physisorbed NO2 gas molecules and two-dimensional (2D) tin disulfide (SnS2) flakes at low operating temperatures.	Nitrogen Dioxide	185-188	sodium voltage-gated channel alpha subunit 11	Homo sapiens	243-247
26447741-7	2015	Such impressive features originate from the planar morphology of 2D SnS2 as well as unique physical affinity and favorable electronic band positions of this material that facilitate the NO2 physisorption and charge transfer at parts per billion levels.	Nitrogen Dioxide	186-189	sodium voltage-gated channel alpha subunit 11	Homo sapiens	68-72
26447741-8	2015	The 2D SnS2-based sensor provides a real solution for low-cost and selective NO2 gas sensing.	Nitrogen Dioxide	77-80	sodium voltage-gated channel alpha subunit 11	Homo sapiens	7-11
26397188-2	2015	The examined compounds are represented as NO2 (Ar)4 NcpH2 , where NO2 (Ar)4 Ncp is the dianion of a tetraaryl N-confused porphyrin with an inner carbon bound NO2 group and Ar is a p-CH3 OPh, p-CH3 Ph, Ph or p-ClPh substituent on each meso-position of the macrocycle.	Nitrogen Dioxide	42-45	calcium binding protein, spermatid associated 1	Homo sapiens	209-213
26397188-2	2015	The examined compounds are represented as NO2 (Ar)4 NcpH2 , where NO2 (Ar)4 Ncp is the dianion of a tetraaryl N-confused porphyrin with an inner carbon bound NO2 group and Ar is a p-CH3 OPh, p-CH3 Ph, Ph or p-ClPh substituent on each meso-position of the macrocycle.	Nitrogen Dioxide	66-69	calcium binding protein, spermatid associated 1	Homo sapiens	209-213
26440130-4	2015	The temperature variation of the (14)N spin-lattice relaxation times T1 is interpreted as due to hindered rotation of the NO2 group about the C-NO2 bond with an activation energy of 89 kJ mol(-1) for the ortho and para groups of monoclinic TNT and 70 kJ mol(-1) for the para group of orthorhombic TNT.	Nitrogen Dioxide	122-125	chromosome 16 open reading frame 82	Homo sapiens	240-243
26440130-4	2015	The temperature variation of the (14)N spin-lattice relaxation times T1 is interpreted as due to hindered rotation of the NO2 group about the C-NO2 bond with an activation energy of 89 kJ mol(-1) for the ortho and para groups of monoclinic TNT and 70 kJ mol(-1) for the para group of orthorhombic TNT.	Nitrogen Dioxide	122-125	chromosome 16 open reading frame 82	Homo sapiens	297-300
25937621-3	2015	The potential of oral NO3(-) to modify exercise/performance via elevation of plasma nitrite concentration ([NO2(-)]) has been applied across a range of human test systems.	Nitrogen Dioxide	108-111	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
26191543-6	2015	Additionally, the quantities of fragment ions of tetryl and adduct ions such as [RDX + NO2](-) and [PETN + NO2](-) were dramatically reduced, which simplified the mass spectra and avoided the overlap of mass peaks for different explosives.	Nitrogen Dioxide	87-90	radixin	Homo sapiens	81-84
26191543-6	2015	Additionally, the quantities of fragment ions of tetryl and adduct ions such as [RDX + NO2](-) and [PETN + NO2](-) were dramatically reduced, which simplified the mass spectra and avoided the overlap of mass peaks for different explosives.	Nitrogen Dioxide	107-110	radixin	Homo sapiens	81-84
26716191-3	2015	Through the use of photochemical oxidation processes the NO and NO2 gases are oxidised to NO3- form and thus removed from the air.	Nitrogen Dioxide	64-67	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
26051522-6	2015	After the NO2(-)/HOCl treatment, Tyr 42 in alpha-chain was found to be nitrated in Hb, attenuating the electron transferring abilities of phenolic compounds.	Nitrogen Dioxide	10-16	Fc gamma receptor and transporter	Homo sapiens	43-54
26273901-4	2015	The assignment of the NO2(-) anion ligand in these complexes, resulting in oxidation from An(V) to An(VI), is substantiated by the replacement of the acetate ligands in AnO2(CH3CO2)2(NO2)(-) and AnO2(CH3CO2)3(-) by nitrites, to produce the tris(nitrite) complexes AnO2(NO2)3(-).	Nitrogen Dioxide	22-25	anoctamin 2	Homo sapiens	169-173
26273901-4	2015	The assignment of the NO2(-) anion ligand in these complexes, resulting in oxidation from An(V) to An(VI), is substantiated by the replacement of the acetate ligands in AnO2(CH3CO2)2(NO2)(-) and AnO2(CH3CO2)3(-) by nitrites, to produce the tris(nitrite) complexes AnO2(NO2)3(-).	Nitrogen Dioxide	22-25	anoctamin 2	Homo sapiens	195-199
26273901-4	2015	The assignment of the NO2(-) anion ligand in these complexes, resulting in oxidation from An(V) to An(VI), is substantiated by the replacement of the acetate ligands in AnO2(CH3CO2)2(NO2)(-) and AnO2(CH3CO2)3(-) by nitrites, to produce the tris(nitrite) complexes AnO2(NO2)3(-).	Nitrogen Dioxide	22-25	anoctamin 2	Homo sapiens	195-199
26273901-4	2015	The assignment of the NO2(-) anion ligand in these complexes, resulting in oxidation from An(V) to An(VI), is substantiated by the replacement of the acetate ligands in AnO2(CH3CO2)2(NO2)(-) and AnO2(CH3CO2)3(-) by nitrites, to produce the tris(nitrite) complexes AnO2(NO2)3(-).	Nitrogen Dioxide	183-186	anoctamin 2	Homo sapiens	169-173
26273901-4	2015	The assignment of the NO2(-) anion ligand in these complexes, resulting in oxidation from An(V) to An(VI), is substantiated by the replacement of the acetate ligands in AnO2(CH3CO2)2(NO2)(-) and AnO2(CH3CO2)3(-) by nitrites, to produce the tris(nitrite) complexes AnO2(NO2)3(-).	Nitrogen Dioxide	183-186	anoctamin 2	Homo sapiens	169-173
26123121-0	2015	Fabrication of SnO2-SnO nanocomposites with p-n heterojunctions for the low-temperature sensing of NO2 gas.	Nitrogen Dioxide	99-102	strawberry notch homolog 2	Homo sapiens	15-18
26321266-3	2015	Despite this long standing association between increased vascular XOR activity and negative clinical outcomes, recent reports reveal a new paradigm whereby the enzymatic activity of XOR mediates beneficial outcomes by catalyzing the one electron reduction of nitrite (NO2(-)) to nitric oxide (NO) when NO2(-) and/or nitrate (NO3(-)) levels are enhanced either via dietary or pharmacologic means.	Nitrogen Dioxide	268-271	xanthine dehydrogenase	Homo sapiens	66-69
26321266-3	2015	Despite this long standing association between increased vascular XOR activity and negative clinical outcomes, recent reports reveal a new paradigm whereby the enzymatic activity of XOR mediates beneficial outcomes by catalyzing the one electron reduction of nitrite (NO2(-)) to nitric oxide (NO) when NO2(-) and/or nitrate (NO3(-)) levels are enhanced either via dietary or pharmacologic means.	Nitrogen Dioxide	268-271	xanthine dehydrogenase	Homo sapiens	182-185
26321266-3	2015	Despite this long standing association between increased vascular XOR activity and negative clinical outcomes, recent reports reveal a new paradigm whereby the enzymatic activity of XOR mediates beneficial outcomes by catalyzing the one electron reduction of nitrite (NO2(-)) to nitric oxide (NO) when NO2(-) and/or nitrate (NO3(-)) levels are enhanced either via dietary or pharmacologic means.	Nitrogen Dioxide	302-305	xanthine dehydrogenase	Homo sapiens	182-185
26123121-4	2015	Compared to the single SnO2-based material, a gas sensor fabricated from the SnO2-SnO composite exhibited an enhanced sensing performance for NO2 gas detection, with a limit of detection and sensitivity of 0.1 ppm and 0.26 ppm(-1), respectively, at a relatively low operating temperature (50  C).	Nitrogen Dioxide	142-145	strawberry notch homolog 2	Homo sapiens	23-26
26123121-4	2015	Compared to the single SnO2-based material, a gas sensor fabricated from the SnO2-SnO composite exhibited an enhanced sensing performance for NO2 gas detection, with a limit of detection and sensitivity of 0.1 ppm and 0.26 ppm(-1), respectively, at a relatively low operating temperature (50  C).	Nitrogen Dioxide	142-145	strawberry notch homolog 2	Homo sapiens	77-80
26123121-6	2015	Such a high sensing sensitivity and a low operating temperature make the SnO2-SnO p-n nanomaterial a promising gas sensor for practical NO2 gas detection.	Nitrogen Dioxide	136-139	strawberry notch homolog 2	Homo sapiens	73-76
25619120-6	2015	There were two reasons: (1) pH can influence the flow direction of electrons afforded by NH2OH oxidation; at high pH, electrons were mainly used for combining H+ and O2 (O2+4H++4e-=2H2O), the accumulation of NO2- cannot be a result of denitrification, and a higher DO can get more electrons to prefer NO2- and (2) NH4+ was the prerequisite for NH2OH oxidation, since NH2OH oxidation process was the way to provide electrons for nitrifier denitrification.	Nitrogen Dioxide	208-211	immunoglobulin kappa variable 1D-39	Homo sapiens	166-168
26179972-6	2015	This is the first study to correlate the dynamics of soil slNH3, NO2(-), N2O and nitrifier genes, and the first to show how ASC can regulate NO2(-) levels and N2O production.	Nitrogen Dioxide	141-144	apoptosis-associated speck-like protein containing a CARD	Bos taurus	124-127
25912222-7	2015	Endogenous TNFalpha neutralization with an anti-TNFalpha monoclonal antibody (mAb) successfully inhibited NO2(-) synthesis by blood mononuclear cells and tumor explants.	Nitrogen Dioxide	106-110	tumor necrosis factor	Homo sapiens	11-19
25912222-7	2015	Endogenous TNFalpha neutralization with an anti-TNFalpha monoclonal antibody (mAb) successfully inhibited NO2(-) synthesis by blood mononuclear cells and tumor explants.	Nitrogen Dioxide	106-110	tumor necrosis factor	Homo sapiens	48-56
25912222-8	2015	Recombinant TNFalpha (rTNFalpha) enhanced NO2(-) synthesis and C666-1 NPC cell proliferation.	Nitrogen Dioxide	42-45	tumor necrosis factor	Homo sapiens	12-20
25912222-8	2015	Recombinant TNFalpha (rTNFalpha) enhanced NO2(-) synthesis and C666-1 NPC cell proliferation.	Nitrogen Dioxide	42-45	tumor necrosis factor	Rattus norvegicus	22-31
25912222-9	2015	NOS2 selective inhibition (1400W) and TNFalpha antagonization with an anti-TNFalpha mAb potently inhibited rTNFalpha induced C666-1 proliferation and NO2(-) production.	Nitrogen Dioxide	150-153	nitric oxide synthase 2	Homo sapiens	0-4
25912222-9	2015	NOS2 selective inhibition (1400W) and TNFalpha antagonization with an anti-TNFalpha mAb potently inhibited rTNFalpha induced C666-1 proliferation and NO2(-) production.	Nitrogen Dioxide	150-153	tumor necrosis factor	Homo sapiens	38-46
25912222-9	2015	NOS2 selective inhibition (1400W) and TNFalpha antagonization with an anti-TNFalpha mAb potently inhibited rTNFalpha induced C666-1 proliferation and NO2(-) production.	Nitrogen Dioxide	150-153	tumor necrosis factor	Homo sapiens	75-83
25912222-9	2015	NOS2 selective inhibition (1400W) and TNFalpha antagonization with an anti-TNFalpha mAb potently inhibited rTNFalpha induced C666-1 proliferation and NO2(-) production.	Nitrogen Dioxide	150-153	tumor necrosis factor	Rattus norvegicus	107-116
25912222-11	2015	Altogether, our results define monocytes/macrophages and the primary tumor as major sources of circulating NO2(-) in NPC patients and support the idea that antibody dependent inhibition of the TNFalpha/NOS2 pathway may alter NPC tumor growth.	Nitrogen Dioxide	107-110	tumor necrosis factor	Homo sapiens	193-201
25912222-11	2015	Altogether, our results define monocytes/macrophages and the primary tumor as major sources of circulating NO2(-) in NPC patients and support the idea that antibody dependent inhibition of the TNFalpha/NOS2 pathway may alter NPC tumor growth.	Nitrogen Dioxide	107-110	nitric oxide synthase 2	Homo sapiens	202-206
25619120-6	2015	There were two reasons: (1) pH can influence the flow direction of electrons afforded by NH2OH oxidation; at high pH, electrons were mainly used for combining H+ and O2 (O2+4H++4e-=2H2O), the accumulation of NO2- cannot be a result of denitrification, and a higher DO can get more electrons to prefer NO2- and (2) NH4+ was the prerequisite for NH2OH oxidation, since NH2OH oxidation process was the way to provide electrons for nitrifier denitrification.	Nitrogen Dioxide	208-211	immunoglobulin kappa variable 1D-39	Homo sapiens	170-172
25619120-6	2015	There were two reasons: (1) pH can influence the flow direction of electrons afforded by NH2OH oxidation; at high pH, electrons were mainly used for combining H+ and O2 (O2+4H++4e-=2H2O), the accumulation of NO2- cannot be a result of denitrification, and a higher DO can get more electrons to prefer NO2- and (2) NH4+ was the prerequisite for NH2OH oxidation, since NH2OH oxidation process was the way to provide electrons for nitrifier denitrification.	Nitrogen Dioxide	301-304	immunoglobulin kappa variable 1D-39	Homo sapiens	166-168
25619120-6	2015	There were two reasons: (1) pH can influence the flow direction of electrons afforded by NH2OH oxidation; at high pH, electrons were mainly used for combining H+ and O2 (O2+4H++4e-=2H2O), the accumulation of NO2- cannot be a result of denitrification, and a higher DO can get more electrons to prefer NO2- and (2) NH4+ was the prerequisite for NH2OH oxidation, since NH2OH oxidation process was the way to provide electrons for nitrifier denitrification.	Nitrogen Dioxide	301-304	immunoglobulin kappa variable 1D-39	Homo sapiens	170-172
27708989-1	2015	Nitrogen dioxide retrievals from the Aura/Ozone Monitoring Instrument (OMI) have been used extensively over the past decade, particularly in the study of tropospheric air quality.	Nitrogen Dioxide	0-16	aurora kinase A	Homo sapiens	37-69
25988324-0	2015	Can a single water molecule really affect the HO2 + NO2 hydrogen abstraction reaction under tropospheric conditions?	Nitrogen Dioxide	52-55	heme oxygenase 2	Homo sapiens	46-49
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Nitrogen Dioxide	124-127	heme oxygenase 2	Homo sapiens	149-164
25988324-2	2015	The reaction without water has three types of reaction channels on both singlet and triplet potential energy surfaces, depending on how the HO2 radical approaches NO2.	Nitrogen Dioxide	163-166	heme oxygenase 2	Homo sapiens	140-143
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Nitrogen Dioxide	141-144	heme oxygenase 2	Homo sapiens	118-121
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Nitrogen Dioxide	141-144	heme oxygenase 2	Homo sapiens	129-132
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Nitrogen Dioxide	124-127	heme oxygenase 2	Homo sapiens	118-121
25988324-5	2015	A single water molecule affects each one of these triplet reaction channels in the three different reactions of H2O   HO2 + NO2, HO2   H2O + NO2 and NO2   H2O + HO2, depending on the way the water interacts.	Nitrogen Dioxide	141-144	heme oxygenase 2	Homo sapiens	149-164
25700865-6	2015	Furthermore, NO2(-) measurement showed linearity of 100 nM to 1mM with a detection limit of 100 nM for NO2(-) and sensitivity of 96.4 nA muM(-1).	Nitrogen Dioxide	13-16	PWWP domain containing 3A, DNA repair factor	Homo sapiens	137-143
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Nitrogen Dioxide	43-46	heme oxygenase 2	Homo sapiens	37-40
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Nitrogen Dioxide	43-46	heme oxygenase 2	Homo sapiens	182-185
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Nitrogen Dioxide	43-46	heme oxygenase 2	Homo sapiens	182-185
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Nitrogen Dioxide	194-197	heme oxygenase 2	Homo sapiens	37-40
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Nitrogen Dioxide	194-197	heme oxygenase 2	Homo sapiens	182-185
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Nitrogen Dioxide	194-197	heme oxygenase 2	Homo sapiens	182-185
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Nitrogen Dioxide	194-197	heme oxygenase 2	Homo sapiens	37-40
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Nitrogen Dioxide	194-197	heme oxygenase 2	Homo sapiens	182-185
25988324-7	2015	The total rate constant of the H2O   HO2 + NO2 reaction is estimated to be slower than the naked reaction by 6 orders of magnitude at 298 K. However, the total rate constants of the HO2   H2O + NO2 and NO2   H2O + HO2 reactions are faster than the naked reaction by 4 and 3 orders of magnitude at 298 K, respectively.	Nitrogen Dioxide	194-197	heme oxygenase 2	Homo sapiens	182-185
26066624-0	2015	HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO2 Production and Neurotoxic Activity.	Nitrogen Dioxide	104-107	TNFAIP3 interacting protein 1	Mus musculus	20-23
25700865-7	2015	Then, the concentration of NO3(-) was measured after its enzymatic conversion into NO2(-).	Nitrogen Dioxide	83-86	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
24618478-12	2015	Analysing by age-specific groups at lag 1, statistically significant associations were found for those aged &gt;=65: 4.5% (95% CI 0.3, 8.9%), 3.4% (95% CI 0.1, 6.9%), and 6.6% (95% CI 2.2, 11.1%) for Leqd, Leqn, and Leq24, with no substantial changes in the effects of noise exposure levels at lag 1 after adjusting for PM2.5 and NO2.	Nitrogen Dioxide	330-333	ceramide synthase 1	Homo sapiens	36-41
25928791-0	2015	Correction: Two types of nitrito support for mu4-oxido-bridged [Cu4] complexes: synthesis, crystal structures, magnetic properties and DFT analysis.	Nitrogen Dioxide	25-32	adaptor related protein complex 4 subunit mu 1	Homo sapiens	45-48
25928791-1	2015	Correction for "Two types of nitrito support for mu4-oxido-bridged [Cu4] complexes: synthesis, crystal structures, magnetic properties and DFT analysis" by Moumita Pait, et al., Dalton Trans., 2015, 44, 6107-6117.	Nitrogen Dioxide	29-36	adaptor related protein complex 4 subunit mu 1	Homo sapiens	49-52
25959902-6	2015	Furthermore, anti-CH3CHOO shows a reactivity greater than syn-CH3CHOO towards NO/NO2; at the later period of reaction, the spectrum can be simulated with only syn-CH3CHOO.	Nitrogen Dioxide	81-84	synemin	Homo sapiens	58-61
25959902-6	2015	Furthermore, anti-CH3CHOO shows a reactivity greater than syn-CH3CHOO towards NO/NO2; at the later period of reaction, the spectrum can be simulated with only syn-CH3CHOO.	Nitrogen Dioxide	81-84	synemin	Homo sapiens	159-162
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Nitrogen Dioxide	199-202	chromosome 16 open reading frame 82	Homo sapiens	82-87
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Nitrogen Dioxide	199-202	chromosome 16 open reading frame 82	Homo sapiens	82-85
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Nitrogen Dioxide	199-202	chromosome 16 open reading frame 82	Homo sapiens	97-100
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Nitrogen Dioxide	199-202	chromosome 16 open reading frame 82	Homo sapiens	148-153
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Nitrogen Dioxide	199-202	chromosome 16 open reading frame 82	Homo sapiens	97-100
26212277-7	2015	It is proposed that the NOx(-) (x = 2, 3) and O3 contributed to the formation of [TNT-H](-) and [TNT-NO](-) ions, via the reactions NOx(-) + TNT   [TNT-H](-) + HNOx and [TNT](-) + O3   [TNT-NO](-) + NO2 + O2.	Nitrogen Dioxide	199-202	chromosome 16 open reading frame 82	Homo sapiens	97-100
26855604-2	2015	The principal indoor source of O3 is air exchange, while OH and NO3 formation are considered as primarily from O3 reactions with alkenes and nitrogen dioxide (NO2), respectively.	Nitrogen Dioxide	141-157	NBL1, DAN family BMP antagonist	Homo sapiens	64-67
26855604-2	2015	The principal indoor source of O3 is air exchange, while OH and NO3 formation are considered as primarily from O3 reactions with alkenes and nitrogen dioxide (NO2), respectively.	Nitrogen Dioxide	159-162	NBL1, DAN family BMP antagonist	Homo sapiens	64-67
26855604-7	2015	Photolysis was a strong OH formation mechanism for high NO, NO2, and HONO settings, but SCI/NO2 reactions weakly generated NO3 except for only a few cases.	Nitrogen Dioxide	92-95	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
25877513-6	2015	Superior adsorption was dominated by various interaction modes including pi-pi electron donor-acceptor interactions between the pi-electron-deficient phenyls of the NACs and the pi-electron-rich matrix of the graphene nanosheets, and the charge electrostatic and polar interactions between the defect sites of graphene nanosheets and the -NO2 of the NAC.	Nitrogen Dioxide	339-342	synuclein alpha	Homo sapiens	165-168
25968258-9	2015	High concentrations of aerosols and water vapor favored the conversion of SO2 to SO4(2-) and NO2 to NO3-, which accelerated the accumulation of the aerosols and resulted in the formation of haze in Beijing.	Nitrogen Dioxide	93-96	NBL1, DAN family BMP antagonist	Homo sapiens	100-103
25783464-2	2015	The nature of the MO(NO3)3(-) products that result from NO2 elimination was evaluated by measuring the relative hydrolysis rates under thermalized conditions.	Nitrogen Dioxide	56-59	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
25695878-4	2015	CID of complexes of the general formula PuOx(NO3)y(-) resulted in the elimination of NO2 to produce PuOx+1(NO3)y-1(-), which in most cases corresponds to an increase in the oxidation state of plutonium.	Nitrogen Dioxide	85-88	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
25704917-1	2015	The reaction between atomic chlorine (Cl) and methyl nitrate (CH3ONO2) is significant in the atmosphere, as Cl is a key oxidant, especially in the marine boundary layer, and alkyl nitrates are important nitrogen-containing organic compounds, which are temporary reservoirs of the reactive nitrogen oxides NO, NO2 and NO3 (NOx).	Nitrogen Dioxide	66-69	NBL1, DAN family BMP antagonist	Homo sapiens	317-320
25763062-2	2014	A strong over expression of IL-6, IL-8, IFNalpha and IFNgamma was observed in bursa at 3 days post inoculation together with an increase in splenic NO2 release.	Nitrogen Dioxide	148-151	interleukin 6	Homo sapiens	28-32
25695878-4	2015	CID of complexes of the general formula PuOx(NO3)y(-) resulted in the elimination of NO2 to produce PuOx+1(NO3)y-1(-), which in most cases corresponds to an increase in the oxidation state of plutonium.	Nitrogen Dioxide	85-88	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
25695878-6	2015	CID of Pu(VI)O2(NO3)3(-) resulted in NO2 elimination to yield PuO3(NO3)2(-), in which the oxidation state of plutonium could be VII, a known oxidation state in condensed phase but not yet in the gas phase.	Nitrogen Dioxide	37-40	NBL1, DAN family BMP antagonist	Homo sapiens	16-19
25695878-6	2015	CID of Pu(VI)O2(NO3)3(-) resulted in NO2 elimination to yield PuO3(NO3)2(-), in which the oxidation state of plutonium could be VII, a known oxidation state in condensed phase but not yet in the gas phase.	Nitrogen Dioxide	37-40	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
25564225-6	2015	The limit of detection (LOD) for NO2(-) is 1.0 muM by eye and 0.1 muM by UV-Vis spectroscopy.	Nitrogen Dioxide	33-36	latexin	Homo sapiens	47-50
25564225-6	2015	The limit of detection (LOD) for NO2(-) is 1.0 muM by eye and 0.1 muM by UV-Vis spectroscopy.	Nitrogen Dioxide	33-36	latexin	Homo sapiens	66-69
25564225-8	2015	There is a good linear relationship between A/A0 and the concentration of NO2(-) from 1.0 to 20.0 muM NO2(-), which permits a quantitative assay.	Nitrogen Dioxide	74-77	latexin	Homo sapiens	98-101
25564225-8	2015	There is a good linear relationship between A/A0 and the concentration of NO2(-) from 1.0 to 20.0 muM NO2(-), which permits a quantitative assay.	Nitrogen Dioxide	102-105	latexin	Homo sapiens	98-101
25601735-6	2015	Adjusting the previous case-crossover analysis suggested a much stronger association between personal NO2 (per 1ppb) (Odds Ratio (OR)=1.276, 95% Credible Interval (CrI): 1.034, 1.569) and emergency room visits for asthma among children relative to the fixed-site estimate (OR=1.024, 95% CrI 1.004-1.045).	Nitrogen Dioxide	102-105	EP300 interacting inhibitor of differentiation 1	Homo sapiens	287-292
25262340-1	2015	In this work, a novel amperometric biosensor of hydrogen peroxide (H2O2) was developed based on the immobilization of myoglobin (Mb) on the surface of the multi-walled carbon nanotube (MWCNT) -Nafion-cysteamine (CA) modified gold electrode (Au) and its electrocatalytic activity was used for the determination of nitrite (NO2(-)).	Nitrogen Dioxide	322-325	myoglobin	Homo sapiens	118-127
25262340-4	2015	It was determined at the characterization studies on the biosensor that linear results are obtained between the ranges of 0.1muM to 70.0muM for H2O2 concentration and 1-250muM for NO2(-).	Nitrogen Dioxide	180-183	latexin	Homo sapiens	125-128
25462318-4	2015	The results showed that NO2 exposure caused the pulmonary pathological alteration, and significantly stimulated MUC5AC expression.	Nitrogen Dioxide	24-27	mucin 5AC, oligomeric mucus/gel-forming	Rattus norvegicus	112-118
25462318-6	2015	Also, NO2 inhalation induced the imbalance in the ratio of Th1/Th2 differentiation (IL-4, IFN-gamma, GATA-3 and T-bet) and the activation of following JAK-STAT pathway (JAK1, JAK3 and STAT6).	Nitrogen Dioxide	6-9	interleukin 4	Rattus norvegicus	84-88
25462318-6	2015	Also, NO2 inhalation induced the imbalance in the ratio of Th1/Th2 differentiation (IL-4, IFN-gamma, GATA-3 and T-bet) and the activation of following JAK-STAT pathway (JAK1, JAK3 and STAT6).	Nitrogen Dioxide	6-9	interferon gamma	Rattus norvegicus	90-99
25462318-6	2015	Also, NO2 inhalation induced the imbalance in the ratio of Th1/Th2 differentiation (IL-4, IFN-gamma, GATA-3 and T-bet) and the activation of following JAK-STAT pathway (JAK1, JAK3 and STAT6).	Nitrogen Dioxide	6-9	GATA binding protein 3	Rattus norvegicus	101-107
25462318-6	2015	Also, NO2 inhalation induced the imbalance in the ratio of Th1/Th2 differentiation (IL-4, IFN-gamma, GATA-3 and T-bet) and the activation of following JAK-STAT pathway (JAK1, JAK3 and STAT6).	Nitrogen Dioxide	6-9	Janus kinase 1	Rattus norvegicus	169-173
25462318-6	2015	Also, NO2 inhalation induced the imbalance in the ratio of Th1/Th2 differentiation (IL-4, IFN-gamma, GATA-3 and T-bet) and the activation of following JAK-STAT pathway (JAK1, JAK3 and STAT6).	Nitrogen Dioxide	6-9	Janus kinase 3	Rattus norvegicus	175-179
25462318-6	2015	Also, NO2 inhalation induced the imbalance in the ratio of Th1/Th2 differentiation (IL-4, IFN-gamma, GATA-3 and T-bet) and the activation of following JAK-STAT pathway (JAK1, JAK3 and STAT6).	Nitrogen Dioxide	6-9	signal transducer and activator of transcription 6	Rattus norvegicus	184-189
26050474-4	2015	The developed method may be used for the nitric oxide determination in 96-well and 48-well microplates; the detection limit is 2.1 +- 0.1 muM for NO2- and 2.9 +- 0.1 muM for NO3-.	Nitrogen Dioxide	146-149	latexin	Homo sapiens	138-141
25485842-4	2015	NO2(-) could be generated by direct formation or NO3(-) reduction via NO.	Nitrogen Dioxide	0-3	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
25485842-5	2015	In a standard selective catalytic reduction (SCR) reaction, NO3(-) was hard to form, because NO2(-) was consumed by ammonia before it could be further oxidized to nitrates.	Nitrogen Dioxide	93-96	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
25673329-5	2015	Unlike wild-type Cx26 hemichannels, which are insensitive to NO and NO2 (-), hemichannels comprising Cx26(K125C) can be opened by NO2 (-) and NO donors.	Nitrogen Dioxide	68-71	gap junction protein beta 2	Homo sapiens	101-105
25673329-5	2015	Unlike wild-type Cx26 hemichannels, which are insensitive to NO and NO2 (-), hemichannels comprising Cx26(K125C) can be opened by NO2 (-) and NO donors.	Nitrogen Dioxide	130-133	gap junction protein beta 2	Homo sapiens	101-105
25366614-7	2015	The addition of an E2 antagonist, ICI (10 muM), prevented the E2-induced increases in NO2 levels (11 % p &gt; 0.05).	Nitrogen Dioxide	86-89	latexin	Homo sapiens	42-45
25366614-8	2015	The combination of E2 (10 nM) and a NOS inhibitor (1400W, 5 muM) inhibited NO2 increases in addition (4 %, p &gt; 0.05).	Nitrogen Dioxide	75-78	latexin	Homo sapiens	60-63
25463703-4	2015	The effect of NO(2) exposure on pollen allergic properties was investigated by quantifying Th2- and Th1-associated chemokines in a model of human dendritic cells.	Nitrogen Dioxide	14-19	negative elongation factor complex member C/D	Homo sapiens	100-103
25766531-10	2015	Moreover, OA-NO2 restored Akt and Gsk 3beta phosphorylation in a PPAR-gamma-dependent way.	Nitrogen Dioxide	13-16	AKT serine/threonine kinase 1	Homo sapiens	26-29
25766531-10	2015	Moreover, OA-NO2 restored Akt and Gsk 3beta phosphorylation in a PPAR-gamma-dependent way.	Nitrogen Dioxide	13-16	glycogen synthase kinase 3 beta	Homo sapiens	34-43
25766531-10	2015	Moreover, OA-NO2 restored Akt and Gsk 3beta phosphorylation in a PPAR-gamma-dependent way.	Nitrogen Dioxide	13-16	peroxisome proliferator activated receptor gamma	Homo sapiens	65-75
25301896-7	2014	These findings suggest that the NO3 (-)-NO2 (-)-NO pathway is a significant modulator of muscle energetics and O2 delivery during hypoxic exercise and subsequent recovery.	Nitrogen Dioxide	36-43	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
25153026-4	2015	In total population, NO2, PM2.5 - 10 and PM10 mass exposure were positively and significantly associated with both osteocalcin and CTx.	Nitrogen Dioxide	21-24	bone gamma-carboxyglutamate protein	Homo sapiens	115-126
25153026-4	2015	In total population, NO2, PM2.5 - 10 and PM10 mass exposure were positively and significantly associated with both osteocalcin and CTx.	Nitrogen Dioxide	21-24	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	131-134
25450018-0	2015	Pulse radiolysis studies of the reactions of nitrogen dioxide with the vitamin B12 complexes cob(II)alamin and nitrocobalamin.	Nitrogen Dioxide	45-61	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	79-82
25450018-2	2015	We report kinetic studies on the reactions of NO2 with two forms of vitamin B12 - cob(II)alamin and nitrocobalamin.	Nitrogen Dioxide	46-49	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	76-79
25617210-7	2015	Moreover, our calculations show that NO2 can be oxidized by CH3NO2 to NO3 radical, which confirms the conclusion reached formerly by Irikura and Johnson [(2006) J Phys Chem A 110:13974-13978] that NO3 radical can be formed during the decomposition of nitramine explosives.	Nitrogen Dioxide	37-40	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
25617210-7	2015	Moreover, our calculations show that NO2 can be oxidized by CH3NO2 to NO3 radical, which confirms the conclusion reached formerly by Irikura and Johnson [(2006) J Phys Chem A 110:13974-13978] that NO3 radical can be formed during the decomposition of nitramine explosives.	Nitrogen Dioxide	37-40	NBL1, DAN family BMP antagonist	Homo sapiens	197-200
26591567-3	2015	The last way is realized mostly at hypoxic state of organisms and heme-containing globins of vertebrates (hemoglobin, myoglobin, cytoglobin, neuroglobin) mediate the transformation of NO2 into NO by means of their nitrite reductase activities.	Nitrogen Dioxide	184-187	myoglobin	Homo sapiens	118-127
26591567-3	2015	The last way is realized mostly at hypoxic state of organisms and heme-containing globins of vertebrates (hemoglobin, myoglobin, cytoglobin, neuroglobin) mediate the transformation of NO2 into NO by means of their nitrite reductase activities.	Nitrogen Dioxide	184-187	cytoglobin	Homo sapiens	129-139
26591567-3	2015	The last way is realized mostly at hypoxic state of organisms and heme-containing globins of vertebrates (hemoglobin, myoglobin, cytoglobin, neuroglobin) mediate the transformation of NO2 into NO by means of their nitrite reductase activities.	Nitrogen Dioxide	184-187	neuroglobin	Homo sapiens	141-152
24760600-9	2014	This study thus identifies NOS3 polymorphism-dependent sensitivity to the effects of physical training on plasma NO2.	Nitrogen Dioxide	113-116	nitric oxide synthase 3	Homo sapiens	27-31
25433598-1	2014	G3(MP2)//B3-CEP theory was applied to study the mechanism of phenol nitration in the gas phase, as promoted by the electrophile NO2 (+).	Nitrogen Dioxide	128-131	tryptase pseudogene 1	Homo sapiens	3-6
25451635-3	2014	Pollutant exposure can also lead to AE COPD, such as NO2, SO2, ozone or particulates (PM10 and PM2.5).	Nitrogen Dioxide	53-56	COPD	Homo sapiens	39-43
25271384-2	2014	Photolysis of NO3(-) leads to NO2 and HONO, both of which play important roles in tropospheric ozone and OH production.	Nitrogen Dioxide	30-33	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
25329713-0	2014	Effects of humidity and [NO3]/[N2O5] ratio on the heterogeneous reaction of fluoranthene and pyrene with N2O5/NO3/NO2.	Nitrogen Dioxide	114-117	NBL1, DAN family BMP antagonist	Homo sapiens	25-28
25329713-0	2014	Effects of humidity and [NO3]/[N2O5] ratio on the heterogeneous reaction of fluoranthene and pyrene with N2O5/NO3/NO2.	Nitrogen Dioxide	114-117	NBL1, DAN family BMP antagonist	Homo sapiens	110-113
25329713-3	2014	In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al.	Nitrogen Dioxide	97-100	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
25329713-3	2014	In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al.	Nitrogen Dioxide	97-100	neurofilament light chain	Homo sapiens	238-241
25329713-3	2014	In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al.	Nitrogen Dioxide	97-100	neuropeptide Y	Homo sapiens	248-251
25329713-7	2014	Decreasing the humidity or increasing the [NO3]/[N2O5] ratio in the reaction essentially increases the concentration radio of [NO3(g)]/[NO2(+)(aq)] on the particle surface (NO2(+) is derived from the ionization of N2O5).	Nitrogen Dioxide	136-139	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
25329713-7	2014	Decreasing the humidity or increasing the [NO3]/[N2O5] ratio in the reaction essentially increases the concentration radio of [NO3(g)]/[NO2(+)(aq)] on the particle surface (NO2(+) is derived from the ionization of N2O5).	Nitrogen Dioxide	136-139	NBL1, DAN family BMP antagonist	Homo sapiens	127-130
25329713-7	2014	Decreasing the humidity or increasing the [NO3]/[N2O5] ratio in the reaction essentially increases the concentration radio of [NO3(g)]/[NO2(+)(aq)] on the particle surface (NO2(+) is derived from the ionization of N2O5).	Nitrogen Dioxide	173-176	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
25329713-7	2014	Decreasing the humidity or increasing the [NO3]/[N2O5] ratio in the reaction essentially increases the concentration radio of [NO3(g)]/[NO2(+)(aq)] on the particle surface (NO2(+) is derived from the ionization of N2O5).	Nitrogen Dioxide	173-176	NBL1, DAN family BMP antagonist	Homo sapiens	127-130
25329713-8	2014	Thus, it can be concluded that under different atmospheric conditions, the change of [NO3(g)]/[NO2(+)(aq)] in the particle surface has an influence on the product distribution of FL and PY in the atmosphere.	Nitrogen Dioxide	95-102	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
25247461-6	2014	The analyses of the surface chemical composition of Fe3O4 by X-ray photoelectron spectroscopy (XPS) reveal that, upon the addition of NO2, the surface is oxidized and a contribution at 532.5 +- 0.4 eV in the O1s spectrum appears, showing that NO2 likely competes with toluene by dissociating on Fe(2+) sites and forming NO3(-).	Nitrogen Dioxide	134-137	NBL1, DAN family BMP antagonist	Homo sapiens	320-323
25458679-0	2014	Experimental study of NO2 reduction in N2/Ar and O2/Ar mixtures by pulsed corona discharge.	Nitrogen Dioxide	22-25	immunoglobulin kappa variable 1D-39	Homo sapiens	49-54
25458679-4	2014	The NO2 reduction was promoted by increasing the specific energy density (SED), and the highest conversion rates were 33.7%, 42.1% and 25.7% for Ar, N2/Ar and O2/Ar, respectively.	Nitrogen Dioxide	4-7	Ocular albinism, autosomal recessive	Homo sapiens	159-164
25458679-5	2014	For a given SED, the NO2 conversion rate had the order N2/Ar&gt;Ar&gt;O2/Ar.	Nitrogen Dioxide	21-24	Ocular albinism, autosomal recessive	Homo sapiens	70-75
25271384-4	2014	We present results of cavity-enhanced absorption spectroscopy measurements of NO2 and HONO emitted during photodegradation of aqueous NO3(-) under acidic conditions.	Nitrogen Dioxide	78-81	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
25271384-7	2014	We find that NO2 is more efficiently hydrolyzed in solution when it is generated in situ during NO3(-) photolysis than for the heterogeneous system where mass transfer of gaseous NO2 into bulk solution is prohibitively slow.	Nitrogen Dioxide	13-16	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
24747297-9	2014	Eosinophil cationic protein in sputum was highly correlated with eosinophil count and increased significantly after exposure to 600 ppb NO2 (p = 0.001).	Nitrogen Dioxide	136-139	ribonuclease A family member 3	Homo sapiens	0-27
25009219-8	2014	The metabolism of NO2 (-) during exercise is altered by NO3 (-) supplementation, exercise, and to a lesser extent, hypoxia.	Nitrogen Dioxide	18-21	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
25173937-0	2014	Nitrate (NO3(-)) and nitrite (NO2(-)) are endocrine disruptors to downregulate expression of tyrosine hydroxylase and motor behavior through conversion to nitric oxide in early development of zebrafish.	Nitrogen Dioxide	30-33	tyrosine hydroxylase	Danio rerio	93-113
24858215-7	2014	In individual subjects (n=37), there was a strong correlation (r=0.75, p&lt;0.0001) between anti-aggregatory effects of NO2(-) and SNP in whole blood, signifying that resultant sGC activation underlies biological effect and responses to NO2(-) are diminished in the presence of NO resistance.	Nitrogen Dioxide	120-123	sarcoglycan beta	Homo sapiens	177-180
24858215-7	2014	In individual subjects (n=37), there was a strong correlation (r=0.75, p&lt;0.0001) between anti-aggregatory effects of NO2(-) and SNP in whole blood, signifying that resultant sGC activation underlies biological effect and responses to NO2(-) are diminished in the presence of NO resistance.	Nitrogen Dioxide	237-240	sarcoglycan beta	Homo sapiens	177-180
24858215-12	2014	In PRP, response to NO2(-) also increased under hypoxia, and was further enhanced (p&lt;0.01) by deoxyHb.	Nitrogen Dioxide	20-23	prion protein	Homo sapiens	3-6
24913985-6	2014	And, preeminent cathepsin B inhibitors were -NO2 functionalized however, -Cl substituted moieties were the most persuasive inhibitors for cathepsin H among all the designed compounds.	Nitrogen Dioxide	45-48	cathepsin B	Homo sapiens	16-27
24913985-6	2014	And, preeminent cathepsin B inhibitors were -NO2 functionalized however, -Cl substituted moieties were the most persuasive inhibitors for cathepsin H among all the designed compounds.	Nitrogen Dioxide	45-48	cathepsin H	Homo sapiens	138-149
25156478-3	2014	The Hal-C bond lengths in F-, Cl-, and Br-C(NO2 )3 in the crystalline state are similar to those in the gas phase.	Nitrogen Dioxide	44-47	histidine ammonia-lyase	Homo sapiens	4-7
24558180-5	2014	An interquartile range (IQR) increase in NO2 exposure in lag 5 was associated with 51%, 10% and 9% increases in CRP, fibrinogen and HGF levels respectively.	Nitrogen Dioxide	41-44	C-reactive protein	Homo sapiens	112-115
24558180-5	2014	An interquartile range (IQR) increase in NO2 exposure in lag 5 was associated with 51%, 10% and 9% increases in CRP, fibrinogen and HGF levels respectively.	Nitrogen Dioxide	41-44	fibrinogen beta chain	Homo sapiens	117-127
24558180-5	2014	An interquartile range (IQR) increase in NO2 exposure in lag 5 was associated with 51%, 10% and 9% increases in CRP, fibrinogen and HGF levels respectively.	Nitrogen Dioxide	41-44	hepatocyte growth factor	Homo sapiens	132-135
24558180-6	2014	We also observed 12% and 8% increases in IL-8 associated with an IQR increase in NO2 exposure in lag 3 and over the year before sampling, respectively.	Nitrogen Dioxide	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
25134574-1	2014	We investigate the formation of aqueous nitrogen dioxide, NO2 formed through femtosecond photolysis of nitrate, NO3- and nitromethane CH3NO2(aq).	Nitrogen Dioxide	58-61	NBL1, DAN family BMP antagonist	Homo sapiens	112-115
25031077-1	2014	Interactions between the NO2 group and 13 different substituents (BF2, BH2, CF3, CH3, CHO, CN, F, NH2, NMe2, NO2, NO, OH, OMe) were investigated computationally for bicyclo[2.2.2]octane (BCO) and benzene substituted at 1,4 and 1,3 positions in the ring.	Nitrogen Dioxide	25-28	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	103-107
24866147-6	2014	The upregulation of PRR expression by Ang II was consistently abolished by L-161982 and ONO and partially suppressed by SC-51382 but was unaffected by L-798106.	Nitrogen Dioxide	88-91	angiotensinogen	Rattus norvegicus	38-44
24866147-10	2014	Both tail cuff plethysmography and telemetry demonstrated attenuation of Ang II hypertension by ONO.	Nitrogen Dioxide	96-99	angiotensinogen	Rattus norvegicus	73-79
24617811-1	2014	This study demonstrates that the production of reactive oxidizing species (e.g., hydroxyl radical ( OH)) during the photolysis of nitrite (NO2(-)) or nitrate (NO3(-)) leads to the oxidative conversion of arsenite (As(III)) to arsenate (As(V)).	Nitrogen Dioxide	139-142	NBL1, DAN family BMP antagonist	Homo sapiens	159-162
24824403-8	2014	The Ag-decorated (BiO)2CO3 microspheres (Ag/BOC) exhibited greatly enhanced photocatalytic activity, photocurrent generation and promoted NO2 oxidation compared to the pure (BiO)2CO3 microspheres.	Nitrogen Dioxide	138-141	BOC cell adhesion associated, oncogene regulated	Homo sapiens	44-47
24840643-2	2014	Here we report a combined high-pressure diffraction and computational study of the structural response to methanol uptake at high pressure on a scandium terephthalate MOF (Sc2BDC3, BDC = 1,4-benzenedicarboxylate) and its nitro-functionalized derivative (Sc2(NO2-BDC)3) and compare it to direct compression behavior in a nonpenetrative hydrostatic fluid, Fluorinert-77.	Nitrogen Dioxide	258-261	lysine acetyltransferase 8	Homo sapiens	167-170
24913400-3	2014	Especially, the 4-pentafluorosulfanylphenyl cation 4-SF5C6H4(+) (m/z 203) from 4-NO2C6H4SF5( +) by loss of  NO2 could occur multiple F-atom migration reactions to the product ion C6H4F3(+) (m/z 133) by loss of SF2 in the MS/MS process.	Nitrogen Dioxide	81-84	serine and arginine rich splicing factor 1	Homo sapiens	210-213
24809325-6	2014	However, OA-NO2 downregulates Lp-PLA2 by inhibiting the p42/p44 mitogen-activated protein kinase (MAPK) and the nuclear factor kappaB (NFkappaB) pathways.	Nitrogen Dioxide	12-15	phospholipase A2 group VII	Sus scrofa	30-37
25126090-8	2014	It is likely that NRT1/NRT2 gene expression and species-dependent apoplastic buffer capacity may be also related to the species-specific foliar NO2 uptake process.	Nitrogen Dioxide	144-147	immunoglobulin superfamily member 9	Homo sapiens	18-22
24631606-8	2014	Maternal NO2 exposure was related with impairment of psychomotor development (beta=-1.30; p=0.05) but not with cognitive function (beta=-0.84; p=0.20).	Nitrogen Dioxide	9-12	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	78-85
24531056-7	2014	RESULTS: A 10-mug/m3 increase in NO2 levels was associated with 1.34 mmHg (95% CI: 0.14, 2.55) higher SBP in nonmedicated individuals, after adjusting for transportation noise.	Nitrogen Dioxide	33-36	selenium binding protein 1	Homo sapiens	102-105
24531056-11	2014	Associations of NO2 with SBP and DBP were stronger in participants with cardiovascular disease, and the association with SBP was stronger in those exposed to high traffic density and traffic noise levels &gt;= 55 dB(A).	Nitrogen Dioxide	16-19	selenium binding protein 1	Homo sapiens	25-28
24531056-12	2014	CONCLUSIONS: We observed a positive association between long-term exposure to NO2 and SBP, after adjustment for transportation noise, which was sensitive to the methodology used to account for medication.	Nitrogen Dioxide	78-81	selenium binding protein 1	Homo sapiens	86-89
24617811-3	2014	Nitrate-mediated photooxidation of As(III) revealed an initial lag phase during which NO3(-) is converted into NO2(-).	Nitrogen Dioxide	111-114	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
24617811-5	2014	On the other hand, alkaline pH that favors the photoinduced transformation of NO3(-) to NO2(-) significantly facilitated the catalytic reduction/oxidation cycling, which enabled the complete oxidation of As(III) at the condition of [As(III)]/[NO2(-)] &gt;&gt; 1 and markedly accelerated NO3(-)-sensitized oxidation of As(III).	Nitrogen Dioxide	88-91	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
24617811-5	2014	On the other hand, alkaline pH that favors the photoinduced transformation of NO3(-) to NO2(-) significantly facilitated the catalytic reduction/oxidation cycling, which enabled the complete oxidation of As(III) at the condition of [As(III)]/[NO2(-)] &gt;&gt; 1 and markedly accelerated NO3(-)-sensitized oxidation of As(III).	Nitrogen Dioxide	88-91	NBL1, DAN family BMP antagonist	Homo sapiens	287-290
24617811-5	2014	On the other hand, alkaline pH that favors the photoinduced transformation of NO3(-) to NO2(-) significantly facilitated the catalytic reduction/oxidation cycling, which enabled the complete oxidation of As(III) at the condition of [As(III)]/[NO2(-)] &gt;&gt; 1 and markedly accelerated NO3(-)-sensitized oxidation of As(III).	Nitrogen Dioxide	243-246	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
24211453-1	2014	We described the preparation of a novel nanobiocomposite, reduced graphene oxide- multiwalled carbon nanotubes-platinum nanoparticles/myoglobin (RGO-MWCNT-Pt/Mb) for the direct electrochemistry of myoglobin and its application towards determination of hydrogen peroxide (H2O2) and nitrite (NO2(-)).	Nitrogen Dioxide	290-293	myoglobin	Homo sapiens	134-143
24447894-0	2014	The kinetics of the reaction of nitrogen dioxide with iron(II)- and iron(III) cytochrome c.	Nitrogen Dioxide	32-48	cytochrome c, somatic	Homo sapiens	78-90
24447894-5	2014	Based on these rate constants, we propose that the reaction with iron(II)cytochrome c proceeds via a mechanism in which 90% of NO2 oxidizes the iron center directly-most probably via reaction at the solvent-accessible heme edge-whereas 10% oxidizes the amino acid residues to the corresponding radicals, which, in turn, oxidize iron(II).	Nitrogen Dioxide	127-130	cytochrome c, somatic	Homo sapiens	73-85
24447894-7	2014	Our results indicate that, in vivo, NO2 will attack preferentially the reduced form of cytochrome c; protein damage is expected to be marginal, the consequence of formation of amino acid radicals on iron(III)cytochrome c.	Nitrogen Dioxide	36-39	cytochrome c, somatic	Homo sapiens	87-99
24447894-7	2014	Our results indicate that, in vivo, NO2 will attack preferentially the reduced form of cytochrome c; protein damage is expected to be marginal, the consequence of formation of amino acid radicals on iron(III)cytochrome c.	Nitrogen Dioxide	36-39	cytochrome c, somatic	Homo sapiens	208-220
25272454-3	2014	Similar rise of the NO2-/NO3- concentration in the rats" blood after "stress", "diabetes mellitus" and "diabetes mellitus + stress" combines with an increase of iNOS transcripts in the myocardium to 6, 5.8 and 51 times compared with control.	Nitrogen Dioxide	20-23	nitric oxide synthase 2	Rattus norvegicus	161-165
24211453-1	2014	We described the preparation of a novel nanobiocomposite, reduced graphene oxide- multiwalled carbon nanotubes-platinum nanoparticles/myoglobin (RGO-MWCNT-Pt/Mb) for the direct electrochemistry of myoglobin and its application towards determination of hydrogen peroxide (H2O2) and nitrite (NO2(-)).	Nitrogen Dioxide	290-293	myoglobin	Homo sapiens	197-206
24385344-9	2014	Administration of OA-NO2 for the final 6.5 weeks of HFD improved glucose tolerance and significantly attenuated HFD-induced RVESP, PVR, RV hypertrophy, lung XO activity, oxidative stress, and pro-inflammatory pulmonary cytokine levels.	Nitrogen Dioxide	21-24	xanthine dehydrogenase	Mus musculus	157-159
24517313-2	2014	Here we address the efficiency and site-selectivity of the nitration reaction of recombinant protein samples of Bet v 1.0101 with different nitrating agents relevant for laboratory investigations (tetranitromethane, TNM), for physiological processes (peroxynitrite, ONOO(-)), and for the health effects of environmental pollutants (nitrogen dioxide and ozone, O3/NO2).	Nitrogen Dioxide	332-348	delta/notch like EGF repeat containing	Homo sapiens	112-115
24517313-2	2014	Here we address the efficiency and site-selectivity of the nitration reaction of recombinant protein samples of Bet v 1.0101 with different nitrating agents relevant for laboratory investigations (tetranitromethane, TNM), for physiological processes (peroxynitrite, ONOO(-)), and for the health effects of environmental pollutants (nitrogen dioxide and ozone, O3/NO2).	Nitrogen Dioxide	363-366	delta/notch like EGF repeat containing	Homo sapiens	112-115
24055935-4	2014	The electrocatalytic activity of SOD1 towards NO2(-) oxidation observed at +0.8 V was linear from 100 nM to 1mM with a detection limit of 50 nM and sensitivity of 98.5 +- 1.7 nA microM(-1)cm(-2).	Nitrogen Dioxide	46-49	superoxide dismutase 1	Homo sapiens	33-37
24243740-8	2014	TNFA -308G&gt;A modified the action of ozone and nitrogen dioxide on lung function, asthma risk, and symptoms; however, the direction of association varied between studies.	Nitrogen Dioxide	49-65	tumor necrosis factor	Homo sapiens	0-4
24243740-9	2014	The TLR4 single-nucleotide polymorphisms rs1927911, rs10759931, and rs6478317 modified the association of particulate matter and nitrogen dioxide with asthma.	Nitrogen Dioxide	129-145	toll like receptor 4	Homo sapiens	4-8
24166465-1	2014	BACKGROUND: We previously reported that radicicol (Hsp90 inhibitor) induced a reduction in the renal blood flow and glomerular filtration rate, in part due to a reduction in urinary NO2/NO3 excretion, suggesting that Hsp90 regulates renal vascular tone in physiological conditions.	Nitrogen Dioxide	182-185	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	51-56
24406683-2	2014	For example, capacity to catalyze the one electron reduction of nitrite (NO2-) to  NO has been reported for hemoglobin, myoglobin and molybdopterin-containing enzymes including xanthine oxidoreductase (XOR) and aldehyde oxidase (AO).	Nitrogen Dioxide	73-76	xanthine dehydrogenase	Homo sapiens	177-200
24406683-2	2014	For example, capacity to catalyze the one electron reduction of nitrite (NO2-) to  NO has been reported for hemoglobin, myoglobin and molybdopterin-containing enzymes including xanthine oxidoreductase (XOR) and aldehyde oxidase (AO).	Nitrogen Dioxide	73-76	xanthine dehydrogenase	Homo sapiens	202-205
24406683-2	2014	For example, capacity to catalyze the one electron reduction of nitrite (NO2-) to  NO has been reported for hemoglobin, myoglobin and molybdopterin-containing enzymes including xanthine oxidoreductase (XOR) and aldehyde oxidase (AO).	Nitrogen Dioxide	73-76	aldehyde oxidase 1	Homo sapiens	211-227
24406683-2	2014	For example, capacity to catalyze the one electron reduction of nitrite (NO2-) to  NO has been reported for hemoglobin, myoglobin and molybdopterin-containing enzymes including xanthine oxidoreductase (XOR) and aldehyde oxidase (AO).	Nitrogen Dioxide	73-76	aldehyde oxidase 1	Homo sapiens	229-231
24406683-11	2014	In contrast to having no effect on XO-catalyzed uric acid production, the AO inhibitor menadione demonstrated potent inhibition of XO-catalyzed NO2- reduction (EC50=60 nM); somewhat similar to the XO-specific inhibitor, febuxostat (EC50=4 nM).	Nitrogen Dioxide	144-147	aldehyde oxidase 1	Homo sapiens	74-76
24339045-1	2014	The reaction of (NO2 )(CF3 SO3 ) and elemental palladium in oleum (65 % SO3 ) leads to violet single crystals of Pd(HS2 O7 )2 (monoclinic, P21 /c, Z=2, a=927.80(9), b=682.58(7), c=920.84(9) pm, beta=117.756(2) , wR2 =0.0439).	Nitrogen Dioxide	17-20	H3 histone pseudogene 16	Homo sapiens	139-142
25101153-8	2014	eNOS was decreased in SAH, MV, and M and NO3 (-)/NO2 (-) were increased in SAH and TA.	Nitrogen Dioxide	49-52	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
24383074-4	2014	The radical Cl2(- ) would also be a major oxidant of nitrite to the nitrating agent ( )NO2 in brackish- and salt-water.	Nitrogen Dioxide	87-90	endogenous retrovirus group W member 5	Homo sapiens	12-15
24659456-3	2014	We then introduced NO2 into the gas mixture as a radical scavenger and determined that the chlorinated species generated by the reaction of SO2 with NaClO2(s) are OClO, Cl, ClO, and Cl2.	Nitrogen Dioxide	19-22	endogenous retrovirus group W member 5	Homo sapiens	182-185
24184213-8	2013	On the aniline ring at position 4 of the quinazoline moiety substituents like NO2, CN, CF3 led to very high BCRP inhibition potencies.	Nitrogen Dioxide	78-81	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	108-112
24125705-5	2013	For the individual treatments, SO2 and NO2 were separately dissolved in the Mg-Al oxide slurry to produce SO3(2-), NO2(-), and NO3(-), which were subsequently removed by the Mg-Al oxide.	Nitrogen Dioxide	39-42	NBL1, DAN family BMP antagonist	Homo sapiens	127-130
24757857-5	2013	The study results permit to suppose that concentration of NO2+RNO in plasma is one of sensitive indicators of presence of inflammatory processes concomitant to premature discharge of amniotic fluid which by its sensitivity and specificity is superior to such indicators as number of leucocytes, ESR and concentration of C-reactive protein.	Nitrogen Dioxide	58-61	C-reactive protein	Homo sapiens	320-338
24012807-8	2013	Our results are consistent with a SN2 mechanism, with Cys sulfenic acid and nitrite anion as products.	Nitrogen Dioxide	76-89	solute carrier family 38 member 5	Homo sapiens	34-37
23454592-2	2013	Despite a long standing association between increased XOR activity and negative clinical outcomes, recent reports describe a paradigm shift where XOR mediates beneficial actions by catalyzing the reduction of NO2(-) to NO.	Nitrogen Dioxide	209-212	xanthine dehydrogenase	Homo sapiens	54-57
23852130-1	2013	In the present work, gold nanocluster (GNC) induced by bovine serum albumin (BSA) was synthesized as a novel fluorescence probe to detect nitrite (NO2(-)) sensitively and selectively.	Nitrogen Dioxide	147-150	albumin	Homo sapiens	62-75
23454592-2	2013	Despite a long standing association between increased XOR activity and negative clinical outcomes, recent reports describe a paradigm shift where XOR mediates beneficial actions by catalyzing the reduction of NO2(-) to NO.	Nitrogen Dioxide	209-212	xanthine dehydrogenase	Homo sapiens	146-149
24056475-12	2013	One-year traffic-NO2 exposure was associated with higher IL-6 levels with each additional IL6-174C allele, and 1-year heating-SO2 exposure with higher levels of TNF-alpha in TNF-308AA homozygotes versus -308G carriers.	Nitrogen Dioxide	17-20	interleukin 6	Homo sapiens	57-61
24030640-0	2013	NO3 radical production from the reaction between the Criegee intermediate CH2OO and NO2.	Nitrogen Dioxide	84-87	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
24030640-1	2013	Formation of the NO3 radical was observed following photolysis of the CH2I2 + O2 system at 248 nm under ambient atmospheric boundary layer conditions (~760 Torr and 297 K) in the presence of NO2.	Nitrogen Dioxide	191-194	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
24054652-0	2013	Design of interpenetrated network MWCNT/poly(1,5-DAN) on interdigital electrode: toward NO2 gas sensing.	Nitrogen Dioxide	88-91	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
24054652-4	2013	The films MWCNT/poly(1,5-DAN) were investigated for gas-sensing to NO2 at low concentration level.	Nitrogen Dioxide	67-70	NBL1, DAN family BMP antagonist	Homo sapiens	25-28
24056475-12	2013	One-year traffic-NO2 exposure was associated with higher IL-6 levels with each additional IL6-174C allele, and 1-year heating-SO2 exposure with higher levels of TNF-alpha in TNF-308AA homozygotes versus -308G carriers.	Nitrogen Dioxide	17-20	interleukin 6	Homo sapiens	90-93
23865889-0	2013	Formation of nitro-PAHs from the heterogeneous reaction of ambient particle-bound PAHs with N2O5/NO3/NO2.	Nitrogen Dioxide	101-104	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
23842530-7	2013	AQP5-L51R has the anion permeability sequence I(-) &gt; NO3(-)   NO2(-) &gt; Br(-) &gt; Cl(-) &gt; HCO3(-) &gt; gluconate.	Nitrogen Dioxide	65-68	aquaporin 5	Homo sapiens	0-4
23666166-9	2013	Insulin resistance increased by 17.0% (95% CI 5.0, 30.3) and 18.7% (95% CI 2.9, 36.9) for every 2SDs increase in ambient NO2 and particulate matter &lt;=10 mum in diameter, respectively.	Nitrogen Dioxide	121-124	insulin	Homo sapiens	0-7
23815641-2	2013	In this reaction, the ONO ligand undergoes a two-electron reduction, with concomitant oxidation of PPh3 to OPPh3 and transformation of the dioxorhenium(V) fragment into a monooxorhenium(V) fragment, constituting a net nonclassical oxygen atom transfer.	Nitrogen Dioxide	22-25	caveolin 1	Homo sapiens	99-103
23559097-6	2013	An analysis of the BDE of the weakest bonds indicates that the substitution of the -NH2 groups and replacing the -NO2 groups of N-NO2 by the -NH2 groups are favorable for improving their thermal stability, while the substitution of -NO2 and increasing the length of original chain decrease their thermal stability.	Nitrogen Dioxide	114-117	homeobox D13	Homo sapiens	19-22
23559097-6	2013	An analysis of the BDE of the weakest bonds indicates that the substitution of the -NH2 groups and replacing the -NO2 groups of N-NO2 by the -NH2 groups are favorable for improving their thermal stability, while the substitution of -NO2 and increasing the length of original chain decrease their thermal stability.	Nitrogen Dioxide	130-133	homeobox D13	Homo sapiens	19-22
23751015-2	2013	The reaction of O3 with NO2 was used for the in situ generation of NO3 radicals in both QUAREC and EUPHORE.	Nitrogen Dioxide	24-27	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
23580524-3	2013	Moreover, we independently probed the two distinct CH3CHOO conformers, syn- and anti-, both of which react readily with SO2 and with NO2.	Nitrogen Dioxide	133-136	synemin	Homo sapiens	71-74
23773147-7	2013	Strong electron-donating or -withdrawing substituents (NPh2 and NO2) and the aromatic substituent BTZ cause a pronounced red-shift of the absorption spectra of 1, 3, and 6.	Nitrogen Dioxide	64-67	neurexophilin 2	Homo sapiens	55-59
23662623-2	2013	One possible secondary reaction is the involvement of NO3(-) and nitrite (NO2(-)) with magnetite, a mixed valence Fe(2+)/Fe(3+) mineral found in many natural environments.	Nitrogen Dioxide	74-77	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
23371061-0	2013	Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease.	Nitrogen Dioxide	75-91	caspase 1	Mus musculus	27-36
23371061-2	2013	NO2 exposure is capable of allergically sensitizing mice to the innocuous inhaled antigen ovalbumin (OVA), promoting neutrophil and eosinophil recruitment, and a mixed Th2/Th17 response upon antigen challenge that is reminiscent of severe asthma.	Nitrogen Dioxide	0-3	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	90-99
23371061-2	2013	NO2 exposure is capable of allergically sensitizing mice to the innocuous inhaled antigen ovalbumin (OVA), promoting neutrophil and eosinophil recruitment, and a mixed Th2/Th17 response upon antigen challenge that is reminiscent of severe asthma.	Nitrogen Dioxide	0-3	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	101-104
23371061-4	2013	We measured the kinetics of lung inflammation after antigen challenge in NO2-promoted allergic airway disease, including inflammatory cells in bronchoalveolar lavage and antigen-specific IL-17A production from the lung.	Nitrogen Dioxide	73-76	interleukin 17A	Mus musculus	187-193
23371061-10	2013	These data implicate a role for caspase-1 and IL-1beta in the IL-1 receptor-dependent Th17 response manifest in NO2-promoted allergic airway disease.	Nitrogen Dioxide	112-115	caspase 1	Mus musculus	32-41
23371061-10	2013	These data implicate a role for caspase-1 and IL-1beta in the IL-1 receptor-dependent Th17 response manifest in NO2-promoted allergic airway disease.	Nitrogen Dioxide	112-115	interleukin 1 beta	Mus musculus	46-54
23378445-11	2013	CONCLUSIONS: Ex vivo thrombin generation was associated with exposure to NO2, nitrate and sulphate, but not PM mass, PM OP or other measured air pollutants.	Nitrogen Dioxide	73-76	coagulation factor II, thrombin	Homo sapiens	21-29
23488820-1	2013	Magnetic hybrid assemblies of Ag and Fe3O4 nanoparticles with biocompatibly immobilized myoglobin (Mb) were designed to detect and capture toxic targets (NO2-, CN-, and H2O2).	Nitrogen Dioxide	154-157	myoglobin	Homo sapiens	88-97
23488820-1	2013	Magnetic hybrid assemblies of Ag and Fe3O4 nanoparticles with biocompatibly immobilized myoglobin (Mb) were designed to detect and capture toxic targets (NO2-, CN-, and H2O2).	Nitrogen Dioxide	154-157	myoglobin	Homo sapiens	99-101
23902123-2	2013	Validation and testing were conducted through kinetic measurements of the reaction of HO2 radicals with NO2, and the results were found to be in good agreement with recent recommended values.	Nitrogen Dioxide	104-107	heme oxygenase 2	Homo sapiens	86-89
22833374-10	2013	However, there was a suggestion of increased risks of RA incidence with increases in NO2 from local traffic and SO2 from home heating sources with stronger associations for the ACPA-negative phenotype.	Nitrogen Dioxide	85-88	proteinase 3	Homo sapiens	177-181
23545404-5	2013	We have demonstrated this HNO mediated acceleration of the nitrite/oxygenated hemoglobin reaction with oxygenated hemoglobin being in excess to HNO and nitrite (as would be found under physiological conditions) by monitoring the formation of methemoglobin in the presence of Angeli"s salt with and without added NO2(-).	Nitrogen Dioxide	312-315	hemoglobin subunit gamma 2	Homo sapiens	242-255
23545404-7	2013	This HNO donor was used both with and without NO2(-) and acceleration of the NO2(-) induced formation of methemoglobin was observed.	Nitrogen Dioxide	77-80	hemoglobin subunit gamma 2	Homo sapiens	105-118
23525930-2	2013	OBJECTIVES: The first longitudinal study to investigate the independent effects of indoor particulate matter (PM) and nitrogen dioxide (NO(2)) concentrations on COPD morbidity in a periurban community.	Nitrogen Dioxide	118-134	COPD	Homo sapiens	161-165
23525930-2	2013	OBJECTIVES: The first longitudinal study to investigate the independent effects of indoor particulate matter (PM) and nitrogen dioxide (NO(2)) concentrations on COPD morbidity in a periurban community.	Nitrogen Dioxide	136-142	COPD	Homo sapiens	161-165
23525930-10	2013	Increases in bedroom NO(2) concentrations were associated with increases in nocturnal symptoms and risk of severe COPD exacerbations.	Nitrogen Dioxide	21-26	COPD	Homo sapiens	114-118
22512656-4	2012	In this study, a tripeptide NGR(NO2) was synthesized and conjugated with 5-fluorouracil.	Nitrogen Dioxide	32-35	reticulon 4 receptor	Homo sapiens	28-31
23168489-5	2013	As well, we found that repeated exposures of the cells to HCHO and NO2 at concentrations that can be found indoors triggered a significant decrease in cell metabolism and an increase in IL-8 release that were not evoked by a single exposure.	Nitrogen Dioxide	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
22949066-0	2013	A B3LYP and MP2(full) theoretical investigation into the strength of the C-NO2 bond upon the formation of the molecule-cation interaction between Na+ and the nitro group of nitrotriazole or its methyl derivatives.	Nitrogen Dioxide	75-78	tryptase pseudogene 1	Homo sapiens	12-15
23144452-6	2012	Dietary CLA and nitrite supplementation in rodents elevates NO(2)-CLA levels in plasma, urine, and tissues, which in turn induces heme oxygenase-1 (HO-1) expression in the colonic epithelium.	Nitrogen Dioxide	60-65	heme oxygenase 1	Homo sapiens	130-146
22922820-7	2012	RESULTS: Higher PM10 and NO2 exposure levels were associated with lower second-trimester maternal sFlt-1 and PlGF levels.	Nitrogen Dioxide	25-28	placental growth factor	Homo sapiens	109-113
22922820-8	2012	PM10 and NO2 exposures averaged over total pregnancy were associated with higher sFlt-1 and lower PlGF levels in fetal cord blood, consistent with an anti-angiogenic state.	Nitrogen Dioxide	9-12	placental growth factor	Homo sapiens	98-102
23033993-8	2012	Exposure to both NO2 and PM(2.5)CAPs increased BAL alpha1-antitrypsin, mean t wave amplitude, the low frequency components of HRV and the LF/HF ratio.	Nitrogen Dioxide	17-20	serpin family A member 1	Homo sapiens	51-69
23360925-8	2013	Co(III) complexes 1 and 2 react with NO2(-), while Fe(III) complexes, 3 and 4, do not react with small amounts of NO(2)(-).	Nitrogen Dioxide	37-40	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	3-6
23436231-0	2013	Does addition of NO2 to carbon-centered radicals yield RONO or RNO2?	Nitrogen Dioxide	17-20	NLR family pyrin domain containing 12	Homo sapiens	63-67
22784779-10	2013	An inverse relationship was found between NO2 levels and the deprivation index (beta = -2.01mug/m(3) in the most deprived quintile compared with lower deprivation, 95%CI: -3.07; -0.95) and a direct relationship was found with age (beta = 0.12mug/m(3) per unit increase in percentage of the population &gt;= 65 years, 95%CI: 0.08; 0.16).	Nitrogen Dioxide	42-45	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	80-89
26281751-4	2013	It is shown here that NO3(-), adsorbed on TiO2 as a byproduct of NO2 disproportionation, was quantitatively converted to surface NO2 and other reduced nitrogenated species under UV irradiation in the absence of moisture.	Nitrogen Dioxide	65-68	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
26281751-4	2013	It is shown here that NO3(-), adsorbed on TiO2 as a byproduct of NO2 disproportionation, was quantitatively converted to surface NO2 and other reduced nitrogenated species under UV irradiation in the absence of moisture.	Nitrogen Dioxide	129-132	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
22981699-5	2013	The results show that despite the use of identical values for k22, there was a 44-fold larger apparent rate of reaction of *NO2 with HbF(NO) compared to HbA(NO), for reactions simulated at 410 muM nitrite and 100 muM hemoglobin (heme basis), 50% oxygen saturation at pH 7.4 and 37 C. This faster reaction was associated with the generation of about 11 muM peak unbound NO.	Nitrogen Dioxide	124-127	latexin	Homo sapiens	193-196
22981699-5	2013	The results show that despite the use of identical values for k22, there was a 44-fold larger apparent rate of reaction of *NO2 with HbF(NO) compared to HbA(NO), for reactions simulated at 410 muM nitrite and 100 muM hemoglobin (heme basis), 50% oxygen saturation at pH 7.4 and 37 C. This faster reaction was associated with the generation of about 11 muM peak unbound NO.	Nitrogen Dioxide	124-127	latexin	Homo sapiens	213-216
22981699-5	2013	The results show that despite the use of identical values for k22, there was a 44-fold larger apparent rate of reaction of *NO2 with HbF(NO) compared to HbA(NO), for reactions simulated at 410 muM nitrite and 100 muM hemoglobin (heme basis), 50% oxygen saturation at pH 7.4 and 37 C. This faster reaction was associated with the generation of about 11 muM peak unbound NO.	Nitrogen Dioxide	124-127	latexin	Homo sapiens	213-216
24175472-3	2013	They consist, from one side, in activating of the constitutive de novo biosynthesis of nitric oxide by cNOS, from other side, in suppression of inducible nitric oxide de novo synthesis by iNOS in such way to prevent the formation of toxic peroxynitrite by co-operation of surplus nitric oxide with superoxide anion, thereby limits the generation of toxic active forms of nitrogen (*NO2) and oxygen (*OH).	Nitrogen Dioxide	382-385	nitric oxide synthase 3	Canis lupus familiaris	103-107
23026532-6	2012	In interferon-beta1b treated MS patients, NO(2)+NO(3), 3-NT and RSNO plasma concentrations were significantly lower (p&lt;0.05), while arginase activity, ADMA and SDMA levels were significantly increased (p&lt;0.05) during the therapy, compared to the baseline levels in treated patients.	Nitrogen Dioxide	42-47	interferon beta 1	Homo sapiens	3-19
22533981-8	2012	Statistical significance was achieved for ONO-5334 doses &gt;=30 mg for C-terminal telopeptide of type 1 collagen (CTX) and &gt;=300 mg for N-terminal telopeptide of type 1 collagen (NTX).	Nitrogen Dioxide	42-45	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	98-114
22579987-4	2012	This review will focus primarily on the genesis of pulmonary allergies and the participation of airway epithelial NF-kappaB activation therein, using examples from our own work on nitrogen dioxide (NO2) exposure and genetic modulation of airway epithelial NF-kappaB activation.	Nitrogen Dioxide	180-196	nuclear factor kappa B subunit 1	Homo sapiens	114-123
22579987-4	2012	This review will focus primarily on the genesis of pulmonary allergies and the participation of airway epithelial NF-kappaB activation therein, using examples from our own work on nitrogen dioxide (NO2) exposure and genetic modulation of airway epithelial NF-kappaB activation.	Nitrogen Dioxide	198-201	nuclear factor kappa B subunit 1	Homo sapiens	114-123
22579987-4	2012	This review will focus primarily on the genesis of pulmonary allergies and the participation of airway epithelial NF-kappaB activation therein, using examples from our own work on nitrogen dioxide (NO2) exposure and genetic modulation of airway epithelial NF-kappaB activation.	Nitrogen Dioxide	198-201	nuclear factor kappa B subunit 1	Homo sapiens	256-265
23387143-0	2012	[Research on the influence of LED temperature shifts on differential optical absorption spectroscopy for measuring NO2].	Nitrogen Dioxide	115-118	small integral membrane protein 10 like 2A	Homo sapiens	30-33
23387143-2	2012	NO2 absorption spectra were formed using LED emitting spectra at 10 degrees C. The measured LED spectra at other temperatures were used as reference spectra of DOAS.	Nitrogen Dioxide	0-3	small integral membrane protein 10 like 2A	Homo sapiens	41-44
22845863-8	2012	Finally, XPS analysis confirms that NO2 adsorbs on CaCO3 (1014) in the form of nitrate (NO3(-)) regardless of environmental conditions or the pretreatment of the calcite surface at different relative humidity.	Nitrogen Dioxide	36-39	NBL1, DAN family BMP antagonist	Homo sapiens	88-91
23213692-4	2012	In single-pollutant models, the best fits for NO2 and SO2 were one day after (Lag1) and the same day visit (Lag0).	Nitrogen Dioxide	46-49	ceramide synthase 1	Homo sapiens	78-82
23213692-5	2012	With an IQR concentration increase in NO2 (Lag1) and SO2 (Lag0), the relative risks of daily hospital admissions for respiratory diseases were 1.060 (95% CI 1.046-1.074) and 1.048 (95% CI 1.031-1.065), respectively.	Nitrogen Dioxide	38-41	ceramide synthase 1	Homo sapiens	43-47
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Nitrogen Dioxide	233-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22770527-8	2012	On the other hand, the RR spectra of the RDX conformers differ from one another, reflecting the importance of the positioning of the NO2 groups with respect to the ring.	Nitrogen Dioxide	133-136	radixin	Homo sapiens	41-44
22609717-7	2012	The mMR was able to remove on average 50% of NH4, 75% of NO2, 35% of NO3 and 60% of PO4 consistently from the MBR effluent under the conditions tested.	Nitrogen Dioxide	57-60	ATPase, class II, type 9B	Mus musculus	4-7
22465477-5	2012	The results with allopurinol and cyanamide suggest that only mitochondrial aldehyde dehydrogenase is involved in the bioactivation of GTN, sodium nitrite, and GSNO, whereas both pathways are involved in the bioactivation of nitrite anion in the intact rat.	Nitrogen Dioxide	224-237	aldehyde dehydrogenase 2 family member	Rattus norvegicus	61-97
22331494-6	2012	ICAM-1 mRNA expression was increased by plasma obtained at both timepoints following the NO(2) exposures.	Nitrogen Dioxide	89-94	intercellular adhesion molecule 1	Homo sapiens	0-6
22192332-10	2012	CONCLUSION: Plasma No2-/No3- and TNF-alpha levels were high in patients with sepsis and septic shock, which increased with severity of sepsis.	Nitrogen Dioxide	19-22	NBL1, DAN family BMP antagonist	Homo sapiens	24-27
26286401-5	2012	This work also suggests that imines will be the main intermediates in the atmospheric oxidation of primary and secondary amines, including amine carbon capture solvents such as 2-aminoethanol (commonly known as monoethanolamine, or MEA), in a process that avoids the ozone-promoting conversion of ( )NO to ( )NO2 commonly encountered in peroxyl radical chemistry.	Nitrogen Dioxide	306-312	male-enhanced antigen 1	Homo sapiens	232-235
22237295-6	2012	RESULTS: We found effects of particle number, black carbon, nitrogen dioxide (NO(2)), and carbon monoxide (CO) on fibrinogen.	Nitrogen Dioxide	60-76	fibrinogen beta chain	Homo sapiens	114-124
22237295-6	2012	RESULTS: We found effects of particle number, black carbon, nitrogen dioxide (NO(2)), and carbon monoxide (CO) on fibrinogen.	Nitrogen Dioxide	78-83	fibrinogen beta chain	Homo sapiens	114-124
22830346-7	2012	The modifications of BAT chemical structure include various substituents introduced to isoindoloquinazoline moiety (Cl, Br, NO(2), CH(2), NH(2), Me, CO(2)Me, OMe).	Nitrogen Dioxide	124-129	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	21-24
22052517-5	2012	We associated the estimated mean levels of nitrogen dioxide at residential addresses since 1971 to incident and fatal stroke by Cox regression analyses and examined the effects by stroke subtypes: ischemic, hemorrhagic, and nonspecified stroke.	Nitrogen Dioxide	43-59	cytochrome c oxidase subunit 8A	Homo sapiens	128-131
22299875-0	2012	17O excess transfer during the NO2 + O3   NO3 + O2 reaction.	Nitrogen Dioxide	31-34	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
21420267-7	2011	TNF-alpha induced NO2/NO3 production by BOECs.	Nitrogen Dioxide	18-21	tumor necrosis factor	Bos taurus	0-9
22295607-6	2011	The mass concentrations of SO4(2-) in PM2.5 had the similar diurnal variation with that of SO2, SO4(2-) in PM2.5 was mainly transformed from SO2, whereas NO3(-) showed difference diurnal variation with that of NO2, and the second conversion rate of NO2 was far lower than that of SO2.	Nitrogen Dioxide	210-213	NBL1, DAN family BMP antagonist	Homo sapiens	154-157
22295607-6	2011	The mass concentrations of SO4(2-) in PM2.5 had the similar diurnal variation with that of SO2, SO4(2-) in PM2.5 was mainly transformed from SO2, whereas NO3(-) showed difference diurnal variation with that of NO2, and the second conversion rate of NO2 was far lower than that of SO2.	Nitrogen Dioxide	249-252	NBL1, DAN family BMP antagonist	Homo sapiens	154-157
21565279-7	2011	Immunocytochemistry performed using NO2-52 also showed that treatment of cells with inhibitors for NOS and sGC completely nullified the elevated immunoreactivity; this indicated that 8-nitro-cGMP is a major component of 8-nitroguanine derivatives produced in cells.	Nitrogen Dioxide	36-39	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	107-110
21524936-0	2011	EPR evidence for the restricted mobility of NO2 in gamma irradiated thorium nitrate pentahydrate Th(NO3)4 5H2O.	Nitrogen Dioxide	44-47	NBL1, DAN family BMP antagonist	Homo sapiens	100-103
22207565-3	2012	In this study, we analysed the association between environmental nitrogen dioxide (NO(2)) exposure and single nucleotide polymorphisms (SNP) in NFE2L2 and KEAP1 genes and their common impact on asthma risk.	Nitrogen Dioxide	65-81	NFE2 like bZIP transcription factor 2	Homo sapiens	144-150
22207565-3	2012	In this study, we analysed the association between environmental nitrogen dioxide (NO(2)) exposure and single nucleotide polymorphisms (SNP) in NFE2L2 and KEAP1 genes and their common impact on asthma risk.	Nitrogen Dioxide	65-81	kelch like ECH associated protein 1	Homo sapiens	155-160
22207565-3	2012	In this study, we analysed the association between environmental nitrogen dioxide (NO(2)) exposure and single nucleotide polymorphisms (SNP) in NFE2L2 and KEAP1 genes and their common impact on asthma risk.	Nitrogen Dioxide	83-89	NFE2 like bZIP transcription factor 2	Homo sapiens	144-150
22207565-3	2012	In this study, we analysed the association between environmental nitrogen dioxide (NO(2)) exposure and single nucleotide polymorphisms (SNP) in NFE2L2 and KEAP1 genes and their common impact on asthma risk.	Nitrogen Dioxide	83-89	kelch like ECH associated protein 1	Homo sapiens	155-160
22047167-9	2011	A similar trend was observed between NO2 exposure and CD4+CD25+ T-cell percentage; however the association was stronger between NO2 exposure and an increased percentage of CD8+ T-cells.	Nitrogen Dioxide	37-40	CD4 molecule	Homo sapiens	54-57
22047167-9	2011	A similar trend was observed between NO2 exposure and CD4+CD25+ T-cell percentage; however the association was stronger between NO2 exposure and an increased percentage of CD8+ T-cells.	Nitrogen Dioxide	128-131	CD8a molecule	Homo sapiens	172-175
21340676-4	2011	In this study, a slightly modified ASM1 model was implemented in the GPS-X software to simulate the concentration of such intermediate products (NO2-, NO and N2O) and to estimate the amounts of gaseous N2O emitted by the denitrification stage (12 biofilters) of the Seine-Centre WWTP (SIAAP, Paris).	Nitrogen Dioxide	145-148	H19 imprinted maternally expressed transcript	Homo sapiens	35-39
21420267-8	2011	The pretreatment of cells with E2 augmented only TNF-alpha-induced NO2/NO3 production (P &lt; 0.05).	Nitrogen Dioxide	67-70	tumor necrosis factor	Bos taurus	49-58
21183608-3	2011	We investigated the associations of EPHX1 Tyr113His and His139Arg polymorphisms with asthma and wheezing outcomes, and focused on the functional genetic change in different ambient nitrogen dioxide (NO2) levels on glutathione S-transferase p1 (GSTP1) and glutathione S-transferase m1 (GSTM1) genotypes.	Nitrogen Dioxide	181-197	glutathione S-transferase pi 1	Homo sapiens	214-242
21326108-4	2011	Exogenous big ET-1 (0.3 nM) significantly increased NOx (NO2/NO3) level in the coronary effluent after onset of reperfusion.	Nitrogen Dioxide	57-60	endothelin 1	Rattus norvegicus	14-18
21412525-0	2011	Damage of aromatic amino acids by the atmospheric free radical oxidant NO3  in the presence of NO2 , N2O4, O3 and O2.	Nitrogen Dioxide	95-98	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
21183608-3	2011	We investigated the associations of EPHX1 Tyr113His and His139Arg polymorphisms with asthma and wheezing outcomes, and focused on the functional genetic change in different ambient nitrogen dioxide (NO2) levels on glutathione S-transferase p1 (GSTP1) and glutathione S-transferase m1 (GSTM1) genotypes.	Nitrogen Dioxide	199-202	glutathione S-transferase pi 1	Homo sapiens	214-242
21183608-8	2011	The risk of EPHX1 139Arg allele and 113Tyr-139Arg diplotype were of greater magnitude in higher compared with lower NO2 communities.	Nitrogen Dioxide	116-119	epoxide hydrolase 1	Homo sapiens	12-17
21183608-9	2011	The increase of the effect from the EPHX1 139Arg allele with higher NO2 exposure was most marked in the GSTP1 Val allele and GSTM1 present genotype.	Nitrogen Dioxide	68-71	epoxide hydrolase 1	Homo sapiens	36-41
21183608-9	2011	The increase of the effect from the EPHX1 139Arg allele with higher NO2 exposure was most marked in the GSTP1 Val allele and GSTM1 present genotype.	Nitrogen Dioxide	68-71	glutathione S-transferase pi 1	Homo sapiens	104-109
21183608-9	2011	The increase of the effect from the EPHX1 139Arg allele with higher NO2 exposure was most marked in the GSTP1 Val allele and GSTM1 present genotype.	Nitrogen Dioxide	68-71	glutathione S-transferase mu 1	Homo sapiens	125-130
21506877-2	2011	We therefore investigated if NO2, an important constituent of traffic-related air pollution, promotes allergic sensitization to the allergen ovalbumin (OVA).	Nitrogen Dioxide	29-32	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	141-150
21506877-7	2011	Both NO2 (25 ppm) and DEP gave lung damage, measured as increased total protein concentration in BALF, whereas only NO2 seemed to stimulate release of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha).	Nitrogen Dioxide	116-119	tumor necrosis factor	Mus musculus	180-207
21506877-7	2011	Both NO2 (25 ppm) and DEP gave lung damage, measured as increased total protein concentration in BALF, whereas only NO2 seemed to stimulate release of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha).	Nitrogen Dioxide	116-119	tumor necrosis factor	Mus musculus	209-218
21216891-0	2011	GSTP1 polymorphism modifies risk for incident asthma associated with nitrogen dioxide in a high-risk birth cohort.	Nitrogen Dioxide	69-85	glutathione S-transferase pi 1	Homo sapiens	0-5
21351530-5	2011	The level of NO2- / NO3- was significantly higher in the azoospermia than in the normal group ([48.56 +/- 8.49] micromol/L versus [25.37 +/- 9.61] micromol/L, P &lt; 0.01).	Nitrogen Dioxide	13-16	NBL1, DAN family BMP antagonist	Homo sapiens	20-23
21432566-9	2010	A 10 mug/m(3) increase in suspended particulate matter (SPM) and nitrogen dioxide (NO(2)) at lag2-lag3 were significantly associated with an increase in asthma hospitalization with ORs of 1.041 (95% CI 1.013-1.070) and 1.112 (95% CI 1.022-1.209), respectively.	Nitrogen Dioxide	65-81	granulysin	Homo sapiens	93-97
20874826-2	2010	Constitutive TGN membrane tubules and those induced by over-expressing kinase dead protein kinase D were inhibited by the PLA(2) inhibitors ONO-RS-082 (ONO) and bromoenol lactone.	Nitrogen Dioxide	140-143	phospholipase A2 group IB	Homo sapiens	122-128
21045638-3	2010	Recently, an alternative pathway for nitric oxide generation was discovered, wherein the inorganic anions nitrate (NO3) and nitrite (NO2), most often considered inert end products from nitric oxide generation, can be reduced back to nitric oxide and other bioactive nitrogen oxide species.	Nitrogen Dioxide	133-136	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
21432566-9	2010	A 10 mug/m(3) increase in suspended particulate matter (SPM) and nitrogen dioxide (NO(2)) at lag2-lag3 were significantly associated with an increase in asthma hospitalization with ORs of 1.041 (95% CI 1.013-1.070) and 1.112 (95% CI 1.022-1.209), respectively.	Nitrogen Dioxide	65-81	lymphocyte activating 3	Homo sapiens	98-102
20669724-6	2010	Differences in groundwater NO3(-) concentrations feeding each stream branch may have significantly influenced NH4(+) and NO2(-) concentrations found in seepage water, which potentially resulted in quantitatively significant NO2(-) formation.	Nitrogen Dioxide	121-124	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
21133087-2	2010	The aptitude to filter nitrogen dioxide and ozone, two of the most significant gaseous pollutants of the atmosphere, have been correlated to both the BET specific surface area studied by N2 adsorption at 77 K, and the presence of chemical functional groups at the surface.	Nitrogen Dioxide	23-39	delta/notch like EGF repeat containing	Homo sapiens	150-153
20586447-9	2010	Statistical regression analysis showed that NO3 was inversely correlated with relative humidity and positively correlated with temperature and to a lesser extent with NO2 and O3, indicating that the heterogeneous removal processes were also important.	Nitrogen Dioxide	167-170	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
20659336-0	2010	NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization.	Nitrogen Dioxide	0-3	integrin subunit alpha X	Homo sapiens	47-52
20659336-9	2010	Lung CD11c+ cells from wildtype mice exhibited a significant increase in MHCII, CD40, and OX40L expression 2 hours following NO2 exposure.	Nitrogen Dioxide	125-128	integrin subunit alpha X	Homo sapiens	5-10
20659336-9	2010	Lung CD11c+ cells from wildtype mice exhibited a significant increase in MHCII, CD40, and OX40L expression 2 hours following NO2 exposure.	Nitrogen Dioxide	125-128	CD40 antigen	Mus musculus	80-84
20659336-9	2010	Lung CD11c+ cells from wildtype mice exhibited a significant increase in MHCII, CD40, and OX40L expression 2 hours following NO2 exposure.	Nitrogen Dioxide	125-128	tumor necrosis factor (ligand) superfamily, member 4	Mus musculus	90-95
20659336-11	2010	CD11c+CD11b- and CD11c+CD11b+ pulmonary cells exposed to NO2 in vivo increased uptake of antigen 2 hours post exposure, with increased ova-Alexa 647+ CD11c+MHCII+ DCs present in MLN from NO2-exposed mice by 48 hours.	Nitrogen Dioxide	57-60	integrin subunit alpha X	Homo sapiens	0-5
20659336-11	2010	CD11c+CD11b- and CD11c+CD11b+ pulmonary cells exposed to NO2 in vivo increased uptake of antigen 2 hours post exposure, with increased ova-Alexa 647+ CD11c+MHCII+ DCs present in MLN from NO2-exposed mice by 48 hours.	Nitrogen Dioxide	57-60	integrin subunit alpha M	Homo sapiens	6-11
20659336-11	2010	CD11c+CD11b- and CD11c+CD11b+ pulmonary cells exposed to NO2 in vivo increased uptake of antigen 2 hours post exposure, with increased ova-Alexa 647+ CD11c+MHCII+ DCs present in MLN from NO2-exposed mice by 48 hours.	Nitrogen Dioxide	57-60	integrin subunit alpha X	Homo sapiens	17-22
20659336-11	2010	CD11c+CD11b- and CD11c+CD11b+ pulmonary cells exposed to NO2 in vivo increased uptake of antigen 2 hours post exposure, with increased ova-Alexa 647+ CD11c+MHCII+ DCs present in MLN from NO2-exposed mice by 48 hours.	Nitrogen Dioxide	57-60	integrin subunit alpha M	Homo sapiens	23-28
20659336-11	2010	CD11c+CD11b- and CD11c+CD11b+ pulmonary cells exposed to NO2 in vivo increased uptake of antigen 2 hours post exposure, with increased ova-Alexa 647+ CD11c+MHCII+ DCs present in MLN from NO2-exposed mice by 48 hours.	Nitrogen Dioxide	57-60	integrin subunit alpha X	Homo sapiens	17-22
20659336-11	2010	CD11c+CD11b- and CD11c+CD11b+ pulmonary cells exposed to NO2 in vivo increased uptake of antigen 2 hours post exposure, with increased ova-Alexa 647+ CD11c+MHCII+ DCs present in MLN from NO2-exposed mice by 48 hours.	Nitrogen Dioxide	187-190	integrin subunit alpha X	Homo sapiens	0-5
20659336-12	2010	Co-cultures of ova-specific CD4+ T cells from naive mice and CD11c+ pulmonary cells from NO2-exposed mice produced IL-1, IL-12p70, and IL-6 in vitro and augmented antigen-induced IL-5 production.	Nitrogen Dioxide	89-92	integrin subunit alpha X	Homo sapiens	61-66
20659336-12	2010	Co-cultures of ova-specific CD4+ T cells from naive mice and CD11c+ pulmonary cells from NO2-exposed mice produced IL-1, IL-12p70, and IL-6 in vitro and augmented antigen-induced IL-5 production.	Nitrogen Dioxide	89-92	interleukin 1 complex	Mus musculus	115-119
20659336-12	2010	Co-cultures of ova-specific CD4+ T cells from naive mice and CD11c+ pulmonary cells from NO2-exposed mice produced IL-1, IL-12p70, and IL-6 in vitro and augmented antigen-induced IL-5 production.	Nitrogen Dioxide	89-92	interleukin 6	Mus musculus	135-139
20659336-12	2010	Co-cultures of ova-specific CD4+ T cells from naive mice and CD11c+ pulmonary cells from NO2-exposed mice produced IL-1, IL-12p70, and IL-6 in vitro and augmented antigen-induced IL-5 production.	Nitrogen Dioxide	89-92	interleukin 5	Mus musculus	179-183
20659336-13	2010	CONCLUSIONS: CD11c+ cells are critical for NO2-promoted allergic sensitization.	Nitrogen Dioxide	43-46	integrin subunit alpha X	Homo sapiens	13-18
20659336-14	2010	NO2 exposure causes pulmonary CD11c+ cells to acquire a phenotype capable of increased antigen uptake, migration to the draining lymph node, expression of MHCII and co-stimulatory molecules required to activate naive T cells, and secretion of polarizing cytokines to shape a Th2/Th17 response.	Nitrogen Dioxide	0-3	integrin subunit alpha X	Homo sapiens	30-35
21241568-10	2010	Plasma IL-6 in high- and middle-dose of glucocorticoids treated group [(15.97 +- 6.18), (19.69 +- 5.52) pg/ml] was significantly decreased as compared to NO2-exposed group [(29.29 +- 9.31) pg/ml] (P &lt; 0.05).	Nitrogen Dioxide	154-157	interleukin 6	Rattus norvegicus	7-11
21241568-11	2010	Plasma IL-10 in high-, middle- and low-dose of glucocorticoids treated group [(23.24 +- 5.14), (27.78 +- 8.17), (33.29 +- 10.42) pg/ml] was significantly reduced compared with NO2-exposed group [(44.38 +- 9.19) pg/ml] (P &lt; 0.05).	Nitrogen Dioxide	176-179	interleukin 10	Rattus norvegicus	7-12
19901348-2	2010	We previously demonstrated that nuclear factor-kappa B (NF-kappaB) activation within airway epithelial cells occurs in response to NO(2) inhalation, and is critical for lipopolysaccharide-induced or antigen-induced inflammatory responses.	Nitrogen Dioxide	131-136	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	32-54
19901348-2	2010	We previously demonstrated that nuclear factor-kappa B (NF-kappaB) activation within airway epithelial cells occurs in response to NO(2) inhalation, and is critical for lipopolysaccharide-induced or antigen-induced inflammatory responses.	Nitrogen Dioxide	131-136	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	56-65
19901348-8	2010	These intriguing findings demonstrate distinct functions of airway epithelial NF-kappaB activities in oxidant-induced severe acute lung injury, and suggest that although airway epithelial NF-kappaB activities modulate NO(2)-induced pulmonary inflammation, additional NF-kappaB-regulated functions confer partial protection from lung injury.	Nitrogen Dioxide	218-223	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	188-197
19901348-8	2010	These intriguing findings demonstrate distinct functions of airway epithelial NF-kappaB activities in oxidant-induced severe acute lung injury, and suggest that although airway epithelial NF-kappaB activities modulate NO(2)-induced pulmonary inflammation, additional NF-kappaB-regulated functions confer partial protection from lung injury.	Nitrogen Dioxide	218-223	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	188-197
20701904-7	2010	Among the 27 risk factors assessed, lower maternal social class, maternal smoking during pregnancy, being first born, shorter breastfeeding, higher DDT levels in cord blood, and higher indoor levels of NO2 (among the non-detoxifiers by GSTP1 polymorphism) were independently associated with poorer cognition.	Nitrogen Dioxide	202-205	glutathione S-transferase pi 1	Homo sapiens	236-241
20669724-6	2010	Differences in groundwater NO3(-) concentrations feeding each stream branch may have significantly influenced NH4(+) and NO2(-) concentrations found in seepage water, which potentially resulted in quantitatively significant NO2(-) formation.	Nitrogen Dioxide	224-227	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
20359034-6	2010	The co-dehydrocoupling of 1 and 2 with AgNO3 even at dry nitrogen atmosphere is occurred, supporting that the oxidation of NO3- ion to NO2 is only the possible oxygen source, but not from the adventitious moisture in air.	Nitrogen Dioxide	135-138	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
19937312-1	2010	Nitrogen dioxide (NO(2))-induced responses in wild type (wt) and salicylic acid (SA)-altering Arabidopsis mutants snc1 (suppressor of npr1-1, constitutive) with high SA level, transgenic line nahG with low SA level, npr1-1 (nonexpressor of PR gene) with SA signaling blockage and double mutant snc1nahG plants, were investigated.	Nitrogen Dioxide	0-16	TIR-NBS-LRR class disease resistance protein	Arabidopsis thaliana	114-118
20055402-9	2010	Lox-DPFs reduced NO(2) from 1.0 +/- 0.3 (engine-out) to 0.42 +/- 0.11 g/kWh (eta = 0.59), whereas hox-DPFs induced a NO(2) formation up to 3.3 +/- 0.7 g/kWh (eta = -2.16).	Nitrogen Dioxide	17-22	lysyl oxidase	Homo sapiens	0-3
19937312-1	2010	Nitrogen dioxide (NO(2))-induced responses in wild type (wt) and salicylic acid (SA)-altering Arabidopsis mutants snc1 (suppressor of npr1-1, constitutive) with high SA level, transgenic line nahG with low SA level, npr1-1 (nonexpressor of PR gene) with SA signaling blockage and double mutant snc1nahG plants, were investigated.	Nitrogen Dioxide	0-16	regulatory protein (NPR1)	Arabidopsis thaliana	134-140
19937312-1	2010	Nitrogen dioxide (NO(2))-induced responses in wild type (wt) and salicylic acid (SA)-altering Arabidopsis mutants snc1 (suppressor of npr1-1, constitutive) with high SA level, transgenic line nahG with low SA level, npr1-1 (nonexpressor of PR gene) with SA signaling blockage and double mutant snc1nahG plants, were investigated.	Nitrogen Dioxide	0-16	regulatory protein (NPR1)	Arabidopsis thaliana	216-222
19733627-2	2009	The aim of this study is to investigate the regulation of the dopamine D(2) receptor mRNA expression in the ganglia of rats with nitrogen dioxide-induced chronic bronchitis compared with that in ganglia of healthy control animals.	Nitrogen Dioxide	129-145	dopamine receptor D2	Homo sapiens	62-84
19906506-7	2009	Plasma concentration of HGF was elevated in ONO-1301-PLGA group (p&lt;0.05).	Nitrogen Dioxide	44-47	hepatocyte growth factor	Mus musculus	24-27
19886653-2	2009	Spectroscopic studies demonstrate that the 5-coordinate O-nitrito complexes Fe(Por)(eta(1)-ONO) (Por--meso-tetraphenyl- or meso-tetra-p-tolyl-porphyrinato dianions) react with the thioethers (R(2)S) dimethylsulfide and tetrahydrothiophene to give the 6-coordinate N-nitrito complexes Fe(Por)(R(2)S)(NO(2)).	Nitrogen Dioxide	57-65	cytochrome p450 oxidoreductase	Homo sapiens	79-82
19886653-2	2009	Spectroscopic studies demonstrate that the 5-coordinate O-nitrito complexes Fe(Por)(eta(1)-ONO) (Por--meso-tetraphenyl- or meso-tetra-p-tolyl-porphyrinato dianions) react with the thioethers (R(2)S) dimethylsulfide and tetrahydrothiophene to give the 6-coordinate N-nitrito complexes Fe(Por)(R(2)S)(NO(2)).	Nitrogen Dioxide	57-65	cytochrome p450 oxidoreductase	Homo sapiens	97-100
19886653-2	2009	Spectroscopic studies demonstrate that the 5-coordinate O-nitrito complexes Fe(Por)(eta(1)-ONO) (Por--meso-tetraphenyl- or meso-tetra-p-tolyl-porphyrinato dianions) react with the thioethers (R(2)S) dimethylsulfide and tetrahydrothiophene to give the 6-coordinate N-nitrito complexes Fe(Por)(R(2)S)(NO(2)).	Nitrogen Dioxide	57-65	cytochrome p450 oxidoreductase	Homo sapiens	97-100
20160357-7	2009	RESULTS: Mean plasma NO2 + NO3 levels were elevated in patients with OPC and oral cancer patients as compared to the controls.	Nitrogen Dioxide	21-26	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
19695219-3	2009	The reversible cytoplasmic PLA(2) antagonist ONO-RS-082 (ONO) produced a concentration-dependent, differential block in the endocytic recycling of both low-density lipoprotein receptor (LDLR) and TfRs, and in the degradative pathways of LDL and epidermal growth factor (EGF).	Nitrogen Dioxide	45-48	phospholipase A2 group IB	Homo sapiens	27-33
19696162-9	2009	Histological and immunohistochemical examinations demonstrated a significant decrease in the degree of cholangitis, biliary epithelial cell kinetics and the expression of iNOS in the biliary epithelium in the ONO group in comparison with the control (P &lt; 0.05).	Nitrogen Dioxide	209-212	nitric oxide synthase, inducible	Mesocricetus auratus	171-175
19696162-10	2009	These results indicate that ONO-1714 represses N-nitrosobis(2-oxopropyl)amine-induced biliary carcinogenesis in bilioenterostomized hamsters and inhibits iNOS expression in the biliary epithelium.	Nitrogen Dioxide	28-31	nitric oxide synthase, inducible	Mesocricetus auratus	154-158
20038054-4	2009	Comparably, the infrared spectrum study showed the same results which indicated that 4-vinylpyridine could associate with the template at two different kinds of binding sites, the P-O-C and the -NO2 site, and is most likely to form steady covalent bonds with methyl parathion, while the other two monomers could only associate with the template at the P-O-C site.	Nitrogen Dioxide	195-198	proopiomelanocortin	Homo sapiens	352-357
19733148-5	2009	The radicals derived from peroxynitrite, nitrogen dioxide and carbonate radical, also inactivated CBS.	Nitrogen Dioxide	41-57	cystathionine beta-synthase	Homo sapiens	98-101
19695219-3	2009	The reversible cytoplasmic PLA(2) antagonist ONO-RS-082 (ONO) produced a concentration-dependent, differential block in the endocytic recycling of both low-density lipoprotein receptor (LDLR) and TfRs, and in the degradative pathways of LDL and epidermal growth factor (EGF).	Nitrogen Dioxide	45-48	low density lipoprotein receptor	Homo sapiens	152-184
19695219-3	2009	The reversible cytoplasmic PLA(2) antagonist ONO-RS-082 (ONO) produced a concentration-dependent, differential block in the endocytic recycling of both low-density lipoprotein receptor (LDLR) and TfRs, and in the degradative pathways of LDL and epidermal growth factor (EGF).	Nitrogen Dioxide	45-48	low density lipoprotein receptor	Homo sapiens	186-190
19695219-3	2009	The reversible cytoplasmic PLA(2) antagonist ONO-RS-082 (ONO) produced a concentration-dependent, differential block in the endocytic recycling of both low-density lipoprotein receptor (LDLR) and TfRs, and in the degradative pathways of LDL and epidermal growth factor (EGF).	Nitrogen Dioxide	45-48	epidermal growth factor	Homo sapiens	245-268
19325986-10	2009	STM shows that the morphology of the particle system is largely conserved during NO(2) exposure at 300 K. The reaction is limited to the formation of surface nitrites and nitrates, which are characterized by low thermal stability and completely decompose below 500 K. As no further sintering occurs before decomposition, NO(2) uptake and release is a fully reversible process.	Nitrogen Dioxide	81-86	sulfotransferase family 1A member 3	Homo sapiens	0-3
19534114-6	2009	The peak intensities of nitrate during the nighttime and high concentrations of O3 and NO2 strongly suggest that the heterogeneous reactions of N2O5 and NO3 onthe aerosol surface dominated the particulate nitrate formation on polluted days.	Nitrogen Dioxide	87-90	NBL1, DAN family BMP antagonist	Homo sapiens	153-156
19126597-7	2009	We also observed nitration, cross-linking of SP-D, and a significant decrease in SP-D-dependent aggregating activity in the lavage of mice acutely exposed to nitrogen dioxide.	Nitrogen Dioxide	158-174	surfactant associated protein D	Mus musculus	45-49
19126597-7	2009	We also observed nitration, cross-linking of SP-D, and a significant decrease in SP-D-dependent aggregating activity in the lavage of mice acutely exposed to nitrogen dioxide.	Nitrogen Dioxide	158-174	surfactant associated protein D	Mus musculus	81-85
19416632-8	2009	Treating healthy rats with NO2-Arg-Trim resulted in a dose-dependent attenuation of CRD-induced nociception and in an inhibition of CRD-induced overexpression of spinal cFOS mRNA.	Nitrogen Dioxide	27-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	169-173
19586913-1	2009	The reduction of nitrite (NO2-) into nitric oxide (NO), catalyzed by nitrite reductase, is an important reaction in the denitrification pathway.	Nitrogen Dioxide	26-29	nitrite reductase large subunit	Achromobacter xylosoxidans	69-86
19153003-1	2009	To apply gliding arc discharge (GAD) plasma processing to volatile organic compounds (VOCs) emission control, the formation of NO(2) as an undesired byproduct needs to be addressed.	Nitrogen Dioxide	127-132	glutamate decarboxylase 1	Homo sapiens	32-35
19153003-2	2009	Comparative results of effluent temperature and product concentrations between experiment and thermodynamic equilibrium calculation show that the NO(2) formation in dry air GAD is totally out of thermodynamic equilibrium.	Nitrogen Dioxide	146-151	glutamate decarboxylase 1	Homo sapiens	173-176
19448737-5	2009	We found that mutations that remove positive charges in the 4th extracellular loop of CFTR (K892Q and R899Q) significantly alter the interaction between extracellular and intracellular Pt(NO2)42- ions.	Nitrogen Dioxide	188-191	CF transmembrane conductance regulator	Homo sapiens	86-90
19325986-10	2009	STM shows that the morphology of the particle system is largely conserved during NO(2) exposure at 300 K. The reaction is limited to the formation of surface nitrites and nitrates, which are characterized by low thermal stability and completely decompose below 500 K. As no further sintering occurs before decomposition, NO(2) uptake and release is a fully reversible process.	Nitrogen Dioxide	321-326	sulfotransferase family 1A member 3	Homo sapiens	0-3
19449765-16	2009	In addition, NO2 had a significant effect on bronchial reactivity and on the amount of interleukin-8 (IL-8) in induced sputum; it also modified the UFP effect on EBC pH and the EC effect on exhaled nitric oxide (eNO).	Nitrogen Dioxide	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	87-100
19496481-4	2009	Using factor analysis, a group of elements consistent with a mobile combustion source (carbon monoxide, nitrogen dioxide, elemental and organic carbon) was significantly associated with total mortality (RR 1.11; 95% CI = 1.083-1.138).	Nitrogen Dioxide	104-120	ribonucleotide reductase catalytic subunit M1	Homo sapiens	203-207
19119806-2	2009	The mechanistic pathways of N-nitrosodimethylamine (NDMA) formation by the reactions of dimethylamine (DMA) with the nitrite anion catalyzed by carbonyl compounds have been investigated using the DFT/B3LYP method at the 6-311+G(d,p) level.	Nitrogen Dioxide	117-130	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	202-205
19449765-16	2009	In addition, NO2 had a significant effect on bronchial reactivity and on the amount of interleukin-8 (IL-8) in induced sputum; it also modified the UFP effect on EBC pH and the EC effect on exhaled nitric oxide (eNO).	Nitrogen Dioxide	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
18844417-2	2008	The parent phenols are regenerated from the O-t-Boc derivatives by the catalyst system CBr4-PPh3 without affecting other protecting groups (aryl alkyl ether, alkyl ester, and thioacetal) or competitive side reaction such as bromination, nitrene (from NO2) and alpha,alpha-dibromoolefine (with CHO/COMe) formation, and transesterification (with CO2Me/Et) taking place.	Nitrogen Dioxide	251-254	BOC cell adhesion associated, oncogene regulated	Homo sapiens	48-51
19759441-1	2009	During ultraviolet light (UV) disinfection, nitrate (NO3-) present in raw water may transform to nitrite (NO2-) that can cause serious human diseases.	Nitrogen Dioxide	106-109	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
19759441-5	2009	Results showed that the formation of NO2- was enhanced at a high initial NO3- concentration and a high pH, but was inhibited, to some different degrees, by introduction of H2O2 or photocatalyst TiO2.	Nitrogen Dioxide	37-40	NBL1, DAN family BMP antagonist	Homo sapiens	73-76
19759441-8	2009	At pH 9.5 and an initial NO3- concentration of 10 mg L(-1) NO3--N, the concentration of NO2- produced was above 0.1 mg L(-1) NO2--N, the Germany drinking water standard.	Nitrogen Dioxide	88-91	NBL1, DAN family BMP antagonist	Homo sapiens	25-28
19759441-8	2009	At pH 9.5 and an initial NO3- concentration of 10 mg L(-1) NO3--N, the concentration of NO2- produced was above 0.1 mg L(-1) NO2--N, the Germany drinking water standard.	Nitrogen Dioxide	88-91	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
19759441-8	2009	At pH 9.5 and an initial NO3- concentration of 10 mg L(-1) NO3--N, the concentration of NO2- produced was above 0.1 mg L(-1) NO2--N, the Germany drinking water standard.	Nitrogen Dioxide	88-92	NBL1, DAN family BMP antagonist	Homo sapiens	25-28
19759441-8	2009	At pH 9.5 and an initial NO3- concentration of 10 mg L(-1) NO3--N, the concentration of NO2- produced was above 0.1 mg L(-1) NO2--N, the Germany drinking water standard.	Nitrogen Dioxide	88-92	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
20357903-6	2009	The possibility of employing Co(III)-tetraphenylporphyrin both as NO(2) (-) selective ionophore and as electron/ion conducting species to ensure ion-to-electron translation was also discussed based on the results of preliminary experiments.	Nitrogen Dioxide	66-71	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	29-36
18974051-7	2008	Importantly, OA-NO2 more potently inhibits cell-associated XOR-dependent O2.	Nitrogen Dioxide	16-19	xanthine dehydrogenase	Homo sapiens	59-62
19248509-3	2008	In the present paper, the fluorescence lifetime of NO2 excited electronic states are observed experimentally by the technique of LIF time decay spectroscopy and with an optical parameter generator and amplifier pumped by a Nd:YAG laser as excitation source.	Nitrogen Dioxide	51-54	LIF interleukin 6 family cytokine	Homo sapiens	129-132
18796295-2	2008	This study shows that a cellular redox agent (nitrogen dioxide) facilitates Ran guanine nucleotide dissociation, and identifies a unique Ran redox architecture involved in that process.	Nitrogen Dioxide	46-62	RAN, member RAS oncogene family	Homo sapiens	76-79
18796295-2	2008	This study shows that a cellular redox agent (nitrogen dioxide) facilitates Ran guanine nucleotide dissociation, and identifies a unique Ran redox architecture involved in that process.	Nitrogen Dioxide	46-62	RAN, member RAS oncogene family	Homo sapiens	137-140
18844417-2	2008	The parent phenols are regenerated from the O-t-Boc derivatives by the catalyst system CBr4-PPh3 without affecting other protecting groups (aryl alkyl ether, alkyl ester, and thioacetal) or competitive side reaction such as bromination, nitrene (from NO2) and alpha,alpha-dibromoolefine (with CHO/COMe) formation, and transesterification (with CO2Me/Et) taking place.	Nitrogen Dioxide	251-254	carbonyl reductase 4	Homo sapiens	87-91
18844417-2	2008	The parent phenols are regenerated from the O-t-Boc derivatives by the catalyst system CBr4-PPh3 without affecting other protecting groups (aryl alkyl ether, alkyl ester, and thioacetal) or competitive side reaction such as bromination, nitrene (from NO2) and alpha,alpha-dibromoolefine (with CHO/COMe) formation, and transesterification (with CO2Me/Et) taking place.	Nitrogen Dioxide	251-254	protein phosphatase 4 catalytic subunit	Homo sapiens	92-96
19031904-5	2008	Results show that the *OH, generated by H2O2 photolysis, could oxidize NH3 to NO2- and further to NO3-.	Nitrogen Dioxide	78-81	NBL1, DAN family BMP antagonist	Homo sapiens	98-101
19031904-10	2008	Since *NHOH could not stay stable in solution, it would rapidly convert to NH2O2- and consequently NO2- and NO3-.	Nitrogen Dioxide	99-102	NBL1, DAN family BMP antagonist	Homo sapiens	108-111
18717599-5	2008	This pathway involves HisE7 in a one or two proton transfer process, depending on whether the active species is nitrite anion or nitrous acid, to yield an intermediate Fe(III)NO species which eventually dissociates leading to NO and methemoglobin.	Nitrogen Dioxide	112-125	hemoglobin subunit gamma 2	Homo sapiens	233-246
18825290-0	2008	Complexes of HNO3 and NO3 - with NO2 and N2O4, and their potential role in atmospheric HONO formation.	Nitrogen Dioxide	33-36	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
18682903-3	2008	Nitrites (NO2-), either present as a contaminant and/or the main metabolic end product of nitric oxide (NO) degradation, may trigger nitrative damage to PON-1 enzyme.	Nitrogen Dioxide	10-13	paraoxonase 1	Homo sapiens	153-158
18560812-3	2008	For coronene and hexabenzocoronene exposed to nitrogen dioxide under simulated diesel exhaust conditions, several reaction products with high molecular mass could be characterized by liquid chromatography-atmospheric pressure chemical (and photo) ionization-mass spectrometry (LC-APCI-MS and LC-APPI-MS).	Nitrogen Dioxide	46-62	amyloid beta precursor protein	Homo sapiens	295-299
18688517-0	2008	Raman spectra of complexes of HNO3 and NO3- with NO2 at surfaces and with N2O4 in solution.	Nitrogen Dioxide	49-52	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
18522101-5	2008	The UV photolysis of NO3- generates ONOO-, *OH, and *NO2 intermediates and the stable NO2- ion.	Nitrogen Dioxide	53-56	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
18522101-5	2008	The UV photolysis of NO3- generates ONOO-, *OH, and *NO2 intermediates and the stable NO2- ion.	Nitrogen Dioxide	86-89	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
18522101-9	2008	Therefore, the NO3- actinometer is preferable at high photon irradiance despite the relatively low quantum yield of NO2- and its dependence on the excitation wavelength.	Nitrogen Dioxide	116-119	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
18311955-8	2008	Our results show that under certain atmospheric conditions, NO3 radicals can be a more important sink for PAHs than NO2, HNO3, N2O5, or O3 and impact tropospheric lifetimes of surface-bound PAHs.	Nitrogen Dioxide	116-119	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
18269242-1	2008	This paper describes a reinvestigation of the literature concerning the synthesis and structural characterization of the platinum(IV)-based anticancer drug known as CPA-7 and believed to be the compound fac-[PtCl3(NO2)(NH 3)2].	Nitrogen Dioxide	214-217	cytochrome P450 family 2 subfamily A member 7	Homo sapiens	165-170
18269242-1	2008	This paper describes a reinvestigation of the literature concerning the synthesis and structural characterization of the platinum(IV)-based anticancer drug known as CPA-7 and believed to be the compound fac-[PtCl3(NO2)(NH 3)2].	Nitrogen Dioxide	214-217	FA complementation group C	Homo sapiens	203-206