PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33990641-0	2021	trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway.	Trans Fatty Acids	0-17	tumor protein p53	Homo sapiens	26-29
33990641-0	2021	trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway.	Trans Fatty Acids	0-17	receptor interacting serine/threonine kinase 1	Homo sapiens	120-124
33990641-0	2021	trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway.	Trans Fatty Acids	0-17	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	125-129
33990641-4	2021	We previously reported that TFAs promote apoptosis induced by doxorubicin (Dox), a double strand break (DSB)-inducing agent, via a non-canonical apoptotic pathway independent of tumor suppressor p53 and apoptosis signal-regulating kinase (ASK1), a reactive oxygen species (ROS)-responsive kinase.	Trans Fatty Acids	28-32	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	239-243
33990641-7	2021	These results demonstrate that in response to CDDP ICLs, TFAs promote p53-dependent apoptosis through the enhancement of the Nox-RIP1-ASK1-MAPK pathway activation, providing insight into the diverse pathogenetic mechanisms of TFAs according to the types of DNA damage.	Trans Fatty Acids	57-61	tumor protein p53	Homo sapiens	70-73
33990641-7	2021	These results demonstrate that in response to CDDP ICLs, TFAs promote p53-dependent apoptosis through the enhancement of the Nox-RIP1-ASK1-MAPK pathway activation, providing insight into the diverse pathogenetic mechanisms of TFAs according to the types of DNA damage.	Trans Fatty Acids	57-61	receptor interacting serine/threonine kinase 1	Homo sapiens	129-133
33990641-7	2021	These results demonstrate that in response to CDDP ICLs, TFAs promote p53-dependent apoptosis through the enhancement of the Nox-RIP1-ASK1-MAPK pathway activation, providing insight into the diverse pathogenetic mechanisms of TFAs according to the types of DNA damage.	Trans Fatty Acids	57-61	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	134-138
33990641-7	2021	These results demonstrate that in response to CDDP ICLs, TFAs promote p53-dependent apoptosis through the enhancement of the Nox-RIP1-ASK1-MAPK pathway activation, providing insight into the diverse pathogenetic mechanisms of TFAs according to the types of DNA damage.	Trans Fatty Acids	226-230	tumor protein p53	Homo sapiens	70-73
33539381-3	2021	Feeding of TFA-containing diet significantly increased the expression of all studied miRs and mTORC1 in all organs examined, except the expression of mTORC1 in the spleen and kidney.	Trans Fatty Acids	11-14	CREB regulated transcription coactivator 1	Mus musculus	94-100
33905135-8	2021	The paternal diet containing TFA down-regulated the expression of PPARbeta and PPARgamma genes, whereas vitamin E-containing diet up-regulated the transcription of PPAR genes.	Trans Fatty Acids	29-32	peroxisome proliferator activated receptor alpha	Rattus norvegicus	66-74
33905135-8	2021	The paternal diet containing TFA down-regulated the expression of PPARbeta and PPARgamma genes, whereas vitamin E-containing diet up-regulated the transcription of PPAR genes.	Trans Fatty Acids	29-32	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	79-88
33905135-8	2021	The paternal diet containing TFA down-regulated the expression of PPARbeta and PPARgamma genes, whereas vitamin E-containing diet up-regulated the transcription of PPAR genes.	Trans Fatty Acids	29-32	peroxisome proliferator activated receptor alpha	Rattus norvegicus	66-70
33539381-0	2021	In vivo effects of olive oil and trans-fatty acids on miR-134, miR-132, miR-124-1, miR-9-3 and mTORC1 gene expression in a DMBA-treated mouse model.	Trans Fatty Acids	33-50	CREB regulated transcription coactivator 1	Mus musculus	95-101
33710636-9	2021	Higher trans-fatty acid consumption was also associated with increased %BOP (p = .05).	Trans Fatty Acids	7-23	BOP	Homo sapiens	72-75
33919141-7	2021	Conversely, dietary ingredients which have a negative effect on the concentration of adiponectin are typical components of the Western diet: saturated fatty acids, trans fatty acids, monosaccharides and disaccharides, and red meat.	Trans Fatty Acids	164-181	adiponectin, C1Q and collagen domain containing	Homo sapiens	85-96
33539381-3	2021	Feeding of TFA-containing diet significantly increased the expression of all studied miRs and mTORC1 in all organs examined, except the expression of mTORC1 in the spleen and kidney.	Trans Fatty Acids	11-14	CREB regulated transcription coactivator 1	Mus musculus	150-156
33255896-0	2020	Metabolomic Analysis of Plasma from GABAB(1) Knock-Out Mice Reveals Decreased Levels of Elaidic Trans-Fatty Acid.	Trans Fatty Acids	96-112	gamma-aminobutyric acid (GABA) B receptor, 1	Mus musculus	36-43
33242520-11	2021	Together, these data indicate that consumption of TFA in different periods of development may increase anxiety-like behavior at least in part via alterations in proinflammatory and anti-inflammatory cytokine levels and GR expression in limbic brain regions.	Trans Fatty Acids	50-53	glutathione-disulfide reductase	Rattus norvegicus	219-221
30536486-1	2019	Producing healthy, high-oleic oils and eliminating trans-fatty acids from foods are two goals that can be addressed by reducing activity of the oleate desaturase, FAD2, in oilseeds.	Trans Fatty Acids	51-68	omega-6 fatty acid desaturase, endoplasmic reticulum	Brassica napus	163-167
31300810-6	2020	The TFA-rich diet significantly increased the expression of pro-inflammatory cytokines, as well as oxidative and endoplasmic reticulum stress, and activated nuclear factor-kappa B (NF-kappaB) and nuclear factor erythroid 2-related factor 2 (NRF2), leading to high p62/sequestosome 1 (SQSTM1) expression.	Trans Fatty Acids	4-7	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-179
31300810-6	2020	The TFA-rich diet significantly increased the expression of pro-inflammatory cytokines, as well as oxidative and endoplasmic reticulum stress, and activated nuclear factor-kappa B (NF-kappaB) and nuclear factor erythroid 2-related factor 2 (NRF2), leading to high p62/sequestosome 1 (SQSTM1) expression.	Trans Fatty Acids	4-7	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	181-190
31300810-6	2020	The TFA-rich diet significantly increased the expression of pro-inflammatory cytokines, as well as oxidative and endoplasmic reticulum stress, and activated nuclear factor-kappa B (NF-kappaB) and nuclear factor erythroid 2-related factor 2 (NRF2), leading to high p62/sequestosome 1 (SQSTM1) expression.	Trans Fatty Acids	4-7	nuclear factor, erythroid derived 2, like 2	Mus musculus	196-239
31300810-6	2020	The TFA-rich diet significantly increased the expression of pro-inflammatory cytokines, as well as oxidative and endoplasmic reticulum stress, and activated nuclear factor-kappa B (NF-kappaB) and nuclear factor erythroid 2-related factor 2 (NRF2), leading to high p62/sequestosome 1 (SQSTM1) expression.	Trans Fatty Acids	4-7	nuclear factor, erythroid derived 2, like 2	Mus musculus	241-245
31300810-6	2020	The TFA-rich diet significantly increased the expression of pro-inflammatory cytokines, as well as oxidative and endoplasmic reticulum stress, and activated nuclear factor-kappa B (NF-kappaB) and nuclear factor erythroid 2-related factor 2 (NRF2), leading to high p62/sequestosome 1 (SQSTM1) expression.	Trans Fatty Acids	4-7	sequestosome 1	Mus musculus	264-282
31300810-6	2020	The TFA-rich diet significantly increased the expression of pro-inflammatory cytokines, as well as oxidative and endoplasmic reticulum stress, and activated nuclear factor-kappa B (NF-kappaB) and nuclear factor erythroid 2-related factor 2 (NRF2), leading to high p62/sequestosome 1 (SQSTM1) expression.	Trans Fatty Acids	4-7	sequestosome 1	Mus musculus	284-290
31300810-7	2020	Furthermore, the TFA diet activated extracellular signal-regulated kinase (ERK) and stimulated the Wnt/beta-catenin signaling pathway, synergistically upregulating cyclin D1 and c-Myc, driving cell proliferation.	Trans Fatty Acids	17-20	mitogen-activated protein kinase 1	Mus musculus	36-73
31300810-7	2020	Furthermore, the TFA diet activated extracellular signal-regulated kinase (ERK) and stimulated the Wnt/beta-catenin signaling pathway, synergistically upregulating cyclin D1 and c-Myc, driving cell proliferation.	Trans Fatty Acids	17-20	mitogen-activated protein kinase 1	Mus musculus	75-78
31300810-7	2020	Furthermore, the TFA diet activated extracellular signal-regulated kinase (ERK) and stimulated the Wnt/beta-catenin signaling pathway, synergistically upregulating cyclin D1 and c-Myc, driving cell proliferation.	Trans Fatty Acids	17-20	catenin (cadherin associated protein), beta 1	Mus musculus	103-115
31300810-7	2020	Furthermore, the TFA diet activated extracellular signal-regulated kinase (ERK) and stimulated the Wnt/beta-catenin signaling pathway, synergistically upregulating cyclin D1 and c-Myc, driving cell proliferation.	Trans Fatty Acids	17-20	cyclin D1	Mus musculus	164-173
31300810-9	2020	In conclusion, these results demonstrate that a TFA-rich diet promotes hepatic tumorigenesis, mainly due to persistent activation of NF-kappaB and NRF2-p62/SQSTM1 signaling, ERK and Wnt/beta-catenin pathways and fibrogenesis.	Trans Fatty Acids	48-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	133-142
31300810-9	2020	In conclusion, these results demonstrate that a TFA-rich diet promotes hepatic tumorigenesis, mainly due to persistent activation of NF-kappaB and NRF2-p62/SQSTM1 signaling, ERK and Wnt/beta-catenin pathways and fibrogenesis.	Trans Fatty Acids	48-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	147-151
31300810-9	2020	In conclusion, these results demonstrate that a TFA-rich diet promotes hepatic tumorigenesis, mainly due to persistent activation of NF-kappaB and NRF2-p62/SQSTM1 signaling, ERK and Wnt/beta-catenin pathways and fibrogenesis.	Trans Fatty Acids	48-51	sequestosome 1	Mus musculus	152-155
31300810-9	2020	In conclusion, these results demonstrate that a TFA-rich diet promotes hepatic tumorigenesis, mainly due to persistent activation of NF-kappaB and NRF2-p62/SQSTM1 signaling, ERK and Wnt/beta-catenin pathways and fibrogenesis.	Trans Fatty Acids	48-51	sequestosome 1	Mus musculus	156-162
31300810-9	2020	In conclusion, these results demonstrate that a TFA-rich diet promotes hepatic tumorigenesis, mainly due to persistent activation of NF-kappaB and NRF2-p62/SQSTM1 signaling, ERK and Wnt/beta-catenin pathways and fibrogenesis.	Trans Fatty Acids	48-51	mitogen-activated protein kinase 1	Mus musculus	174-177
31300810-9	2020	In conclusion, these results demonstrate that a TFA-rich diet promotes hepatic tumorigenesis, mainly due to persistent activation of NF-kappaB and NRF2-p62/SQSTM1 signaling, ERK and Wnt/beta-catenin pathways and fibrogenesis.	Trans Fatty Acids	48-51	catenin (cadherin associated protein), beta 1	Mus musculus	186-198
31675245-11	2019	The present study proposes a link between PPARgamma gene expression level and motility in human sperm.Abbreviations: PPARs: Peroxisome Proliferator-Activated Receptors; CASA: Computer Assisted Semen Analysis; TFA: Trans Fatty Acids; HTF: Human Tubal Fluid; PBS: Phosphate-Buffered Saline; PPP: Pentose Phosphate Pathway; PI3K: Phosphoinositide 3-Kinase; G6PDH: Glucose 6-Phosphate Dehydrogenase.	Trans Fatty Acids	214-231	peroxisome proliferator activated receptor gamma	Homo sapiens	42-51
30981483-18	2019	Although animal performance was similar, some trans fatty acid isomers were persistent in the milk through the recovery phase with HDS-fed animals, suggesting that milk fat synthesis might be potentially inhibited and biohydrogenation pathways modified in the rumen following an episode of MFD.	Trans Fatty Acids	46-62	Weaning weight-maternal milk	Bos taurus	94-98
30981483-18	2019	Although animal performance was similar, some trans fatty acid isomers were persistent in the milk through the recovery phase with HDS-fed animals, suggesting that milk fat synthesis might be potentially inhibited and biohydrogenation pathways modified in the rumen following an episode of MFD.	Trans Fatty Acids	46-62	Weaning weight-maternal milk	Bos taurus	164-168
30954417-10	2019	GRS and TFA intakes significantly interacted in altering the BMI and WC; thus, a higher intake of TFAs was associated with higher changes of BMI and WC in subjects with high GRS (P trend<0.05) compared to individuals with low GRS.	Trans Fatty Acids	98-102	coagulation factor III, tissue factor	Homo sapiens	8-11
32822725-0	2020	Elaidate, a trans fatty acid, suppresses insulin signaling for glucose uptake in a manner distinct from that of stearate.	Trans Fatty Acids	12-28	insulin	Homo sapiens	41-48
32423040-1	2020	Intake of industrially produced trans fatty acids (iTFAs) has previously been associated with dyslipidemia, insulin resistance, hypertension and inflammation, as well as increased cardiovascular (CV) morbidity and mortality.	Trans Fatty Acids	32-49	insulin	Homo sapiens	108-115
31782488-9	2020	In cultured hepatocytes and adipocytes, industrial trans fatty acids, but not cis-unsaturated fatty acids or SFAs, stimulate the cholesterol synthesis pathway by activating sterol regulatory element binding protein (SREBP) 2-mediated gene regulation.	Trans Fatty Acids	51-68	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	173-214
31782488-9	2020	In cultured hepatocytes and adipocytes, industrial trans fatty acids, but not cis-unsaturated fatty acids or SFAs, stimulate the cholesterol synthesis pathway by activating sterol regulatory element binding protein (SREBP) 2-mediated gene regulation.	Trans Fatty Acids	51-68	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	216-221
31582606-8	2019	We also found that trans-fatty acids (TFAs) enhance ROS-dependent ASK1 activation induced by extracellular ATP, a damage-associated molecular pattern (DAMP), and thereby promotes apoptosis, which possibly contributes to the pathogenesis of TFA-related diseases including atherosclerosis.	Trans Fatty Acids	19-36	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	66-70
30813339-1	2019	Interesterified fats are being widely used by the food industry in an attempt to replace trans fatty acids.	Trans Fatty Acids	89-106	DNA segment, Chr 7, ERATO Doi 443, expressed	Mus musculus	16-20
31582606-8	2019	We also found that trans-fatty acids (TFAs) enhance ROS-dependent ASK1 activation induced by extracellular ATP, a damage-associated molecular pattern (DAMP), and thereby promotes apoptosis, which possibly contributes to the pathogenesis of TFA-related diseases including atherosclerosis.	Trans Fatty Acids	38-42	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	66-70
31582606-8	2019	We also found that trans-fatty acids (TFAs) enhance ROS-dependent ASK1 activation induced by extracellular ATP, a damage-associated molecular pattern (DAMP), and thereby promotes apoptosis, which possibly contributes to the pathogenesis of TFA-related diseases including atherosclerosis.	Trans Fatty Acids	38-41	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	66-70
28950350-8	2017	Levels of industrial trans-fatty acids were positively associated with ER-negative tumours [OR for the highest tertile compared with the lowest (T3-T1)=2.01; 95% CI, 1.03-3.90; P for trend = 0.047], whereas no association was found for ER-positive tumours (P-heterogeneity =0.01).	Trans Fatty Acids	21-38	estrogen receptor 1	Homo sapiens	71-73
29491274-9	2018	TFA intake led to a significant decrease of AChE in all TFA groups, and the increase in levels of NOS in the high-dose group.	Trans Fatty Acids	0-3	acetylcholinesterase	Mus musculus	44-48
29237473-12	2017	Additionally, considering that FASN and ACLY contribute to hepatic lipogenesis, our results suggest a potential mechanism for the dyslipidemia in adult male mice that is associated with TFA diets.	Trans Fatty Acids	186-189	fatty acid synthase	Mus musculus	31-35
29237473-12	2017	Additionally, considering that FASN and ACLY contribute to hepatic lipogenesis, our results suggest a potential mechanism for the dyslipidemia in adult male mice that is associated with TFA diets.	Trans Fatty Acids	186-189	ATP citrate lyase	Mus musculus	40-44
28676973-7	2018	RESULTS: Long-term feeding of fructose in combination with SFA or TFA induced hepatic steatosis of similar extent associated with upregulation of stearoyl CoA desaturase-1.	Trans Fatty Acids	66-69	stearoyl-CoA desaturase	Rattus norvegicus	146-171
30122193-2	2018	In a Mexican population characterized by high-fat consumption, we hypothesized that the Pro12Ala PPARgamma genotype is related to obesity and this relationship is modulated by intake of saturated fatty acids (SFAs) and trans-fatty acids (TFAs).	Trans Fatty Acids	219-236	peroxisome proliferator activated receptor gamma	Homo sapiens	97-106
30122193-2	2018	In a Mexican population characterized by high-fat consumption, we hypothesized that the Pro12Ala PPARgamma genotype is related to obesity and this relationship is modulated by intake of saturated fatty acids (SFAs) and trans-fatty acids (TFAs).	Trans Fatty Acids	238-242	peroxisome proliferator activated receptor gamma	Homo sapiens	97-106
29998870-8	2018	In women, TNF-alpha had a significant positive association with total omega-3 (P <0.05) and omega-6 (P <0.01) PUFAs, IL-6 had a significant (P <0.05) positive association with total monounsaturated fatty acids and MCP-1 had a significant positive association with total trans-fatty acids (P <0.05).	Trans Fatty Acids	279-296	tumor necrosis factor	Homo sapiens	10-19
29998870-8	2018	In women, TNF-alpha had a significant positive association with total omega-3 (P <0.05) and omega-6 (P <0.01) PUFAs, IL-6 had a significant (P <0.05) positive association with total monounsaturated fatty acids and MCP-1 had a significant positive association with total trans-fatty acids (P <0.05).	Trans Fatty Acids	279-296	interleukin 6	Homo sapiens	123-127
29578285-2	2018	Previous studies demonstrated that TFA was associated with coronary heart disease, obesity, and insulin resistance.	Trans Fatty Acids	35-38	insulin	Homo sapiens	96-103
27511058-1	2017	PURPOSE: Interesterification of palm stearin and palm kernal (PSt/PK) is widely used by the food industry to create fats with desirable functional characteristics for applications in spreads and bakery products, negating the need for trans fatty acids.	Trans Fatty Acids	234-251	sulfotransferase family 1A member 1	Homo sapiens	62-65
28484112-8	2017	CONCLUSIONS: These results suggest that excessive TFA intake worsens insulin resistance and increases the risk of developing DM even in the native Japanese, whose intakes of animal fat and simple carbohydrates were presumed to be lower than those of the Japanese-Americans.	Trans Fatty Acids	50-53	insulin	Homo sapiens	69-76
28674325-0	2017	Is the Association between Dietary Trans Fatty Acids and Insulin Resistance Remarkable in Japan?	Trans Fatty Acids	35-52	insulin	Homo sapiens	57-64
27627219-1	2017	INTRODUCTION: Ruminant trans-fatty acids, especially cis9, trans11-conjugated linoleic acid (c9,t11-CLA) and trans11-18:1 vaccenic acid (t11-18:1 VA) appear to have anticarcinogenic activity against breast cancer in animal and in vitro experiments.	Trans Fatty Acids	23-40	selectin P ligand	Homo sapiens	100-103
28950350-8	2017	Levels of industrial trans-fatty acids were positively associated with ER-negative tumours [OR for the highest tertile compared with the lowest (T3-T1)=2.01; 95% CI, 1.03-3.90; P for trend = 0.047], whereas no association was found for ER-positive tumours (P-heterogeneity =0.01).	Trans Fatty Acids	21-38	estrogen receptor 1	Homo sapiens	236-238
28950350-11	2017	Dietary trans-fatty acids derived from industrial processes may specifically increase ER-negative breast cancer risk.	Trans Fatty Acids	8-25	estrogen receptor 1	Homo sapiens	86-88
28924084-0	2017	Comparison of the Effect of trans Fatty Acid Isomers on Apolipoprotein A1 and B Secretion in HepG2 Cells.	Trans Fatty Acids	28-44	apolipoprotein A1	Homo sapiens	56-73
28924084-5	2017	The secretion amount of apolipoprotein B tended to increase with the number of double bonds in TFA among trans-9-18:1, t9,t12-18:2, and t-18:3.	Trans Fatty Acids	95-98	apolipoprotein B	Homo sapiens	24-40
28924084-6	2017	The secretion amount of apolipoprotein A1 after TFA treatment was also measured.	Trans Fatty Acids	48-51	apolipoprotein A1	Homo sapiens	24-41
28503432-8	2017	Factor 2 was characterized by oleic acid, monounsaturated fats, polyunsaturated fats, linoleic acid, trans fatty acid, linolenic acid, vitamin E and saturated fats (fatty acid pattern).	Trans Fatty Acids	101-117	transcription termination factor 2	Homo sapiens	0-8
28360100-5	2017	Major food-associated TFAs such as elaidic acid (EA), linoelaidic acid, and trans-vaccenic acid, but not their corresponding cis isomers, dramatically enhanced extracellular ATP-induced apoptosis, accompanied by elevated activation of the ASK1-p38 pathway in a macrophage-like cell line, RAW264.7.	Trans Fatty Acids	22-26	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	239-243
28360100-9	2017	These results demonstrate that TFAs promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of TFA-induced atherosclerosis.	Trans Fatty Acids	31-35	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	93-97
28360100-9	2017	These results demonstrate that TFAs promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of TFA-induced atherosclerosis.	Trans Fatty Acids	31-34	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	93-97
28601456-10	2017	Milk fat from cows fed the alternative forage diets contained higher concentrations of 4:0, 6:0, and 18:0 and tended to have lower concentrations of total trans fatty acids.	Trans Fatty Acids	155-172	Weaning weight-maternal milk	Bos taurus	0-4
28315997-0	2017	Trans Fatty Acids Suppress TNF-alpha-Induced Inflammatory Gene Expression in Endothelial (HUVEC) and Hepatocellular Carcinoma (HepG2) Cells.	Trans Fatty Acids	0-17	tumor necrosis factor	Homo sapiens	27-36
28360100-0	2017	trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway.	Trans Fatty Acids	0-17	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	86-122
28360100-0	2017	trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway.	Trans Fatty Acids	0-17	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	124-128
28360100-4	2017	Here we have shown that TFAs potentiate activation of apoptosis signal-regulating kinase 1 (ASK1) induced by extracellular ATP, a damage-associated molecular pattern leaked from injured cells.	Trans Fatty Acids	24-28	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	54-90
28360100-4	2017	Here we have shown that TFAs potentiate activation of apoptosis signal-regulating kinase 1 (ASK1) induced by extracellular ATP, a damage-associated molecular pattern leaked from injured cells.	Trans Fatty Acids	24-28	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	92-96
28315997-5	2017	Incorporation of EA, a common industrial TFA, increased the ratio of the stearoyl-CoA desaturase (SCD-1), a key enzyme involved in fatty acid metabolism.	Trans Fatty Acids	41-44	stearoyl-CoA desaturase	Homo sapiens	73-96
28315997-5	2017	Incorporation of EA, a common industrial TFA, increased the ratio of the stearoyl-CoA desaturase (SCD-1), a key enzyme involved in fatty acid metabolism.	Trans Fatty Acids	41-44	stearoyl-CoA desaturase	Homo sapiens	98-103
28315997-6	2017	Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-alpha-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells.	Trans Fatty Acids	9-12	tumor necrosis factor	Homo sapiens	91-100
28315997-6	2017	Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-alpha-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells.	Trans Fatty Acids	9-12	tumor necrosis factor	Homo sapiens	91-94
28315997-6	2017	Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-alpha-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells.	Trans Fatty Acids	9-12	vascular cell adhesion molecule 1	Homo sapiens	133-139
28315997-6	2017	Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-alpha-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells.	Trans Fatty Acids	9-12	superoxide dismutase 2	Homo sapiens	144-148
28315997-6	2017	Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-alpha-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells.	Trans Fatty Acids	9-12	tumor necrosis factor	Homo sapiens	128-131
28315997-6	2017	Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-alpha-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells.	Trans Fatty Acids	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
28781892-2	2017	We investigated the association of serum TFAs with high sensitivity C-reactive protein (hs-CRP) and fibrinogen in adult Americans.	Trans Fatty Acids	41-45	C-reactive protein	Homo sapiens	68-86
28340087-0	2017	Nutrigenomic point of view on effects and mechanisms of action of ruminant trans fatty acids on insulin resistance and type 2 diabetes.	Trans Fatty Acids	75-92	insulin	Homo sapiens	96-103
28340087-1	2017	Evidence from observational studies suggests beneficial effects of ruminant trans fatty acids (rTFA) on insulin resistance (IR) and type 2 diabetes (T2D).	Trans Fatty Acids	76-93	insulin	Homo sapiens	104-111
27816763-0	2017	PPARalpha protects against trans-fatty-acid-containing diet-induced steatohepatitis.	Trans Fatty Acids	27-43	peroxisome proliferator activated receptor alpha	Mus musculus	0-9
27816763-5	2017	Ppara-null mice fed a TFA-containing diet showed more severe hepatic steatosis and liver damage compared with similarly treated wild-type mice, as revealed by increased hepatic triglyceride (TG) contents and serum alanine aminotransferase activities.	Trans Fatty Acids	22-25	peroxisome proliferator activated receptor alpha	Mus musculus	0-5
27816763-6	2017	While the TFA-rich diet increased the hepatic expression of enzymes involved in de novo FA synthesis and decreased TG-hydrolyzing enzymes in both genotypes, the expression of FA-catabolizing enzymes was decreased in Ppara-null mice, resulting in more severe hepatosteatosis.	Trans Fatty Acids	10-13	peroxisome proliferator activated receptor alpha	Mus musculus	216-221
27816763-7	2017	Additionally, the expression levels of key contributors to inflammation, such as osteopontin, were increased, and nuclear factor-kappa B was activated in TFA-containing diet-fed Ppara-null mice.	Trans Fatty Acids	154-157	peroxisome proliferator activated receptor alpha	Mus musculus	178-183
27816763-9	2017	Collectively, these results suggest a protective role for PPARalpha in the pathological changes in the liver following TFA consumption.	Trans Fatty Acids	119-122	peroxisome proliferator activated receptor alpha	Mus musculus	58-67
27816763-10	2017	PPARalpha might prevent TFA-containing diet-induced steatohepatitis.	Trans Fatty Acids	24-27	peroxisome proliferator activated receptor alpha	Mus musculus	0-9
27853933-4	2017	The results showed that the levels of nuclear translocation of NF-kappaB p65 and phosphorylated ERK1/2 were significantly decreased only in non-lipid rafts cells pretreated with trans fatty acid (TFA).	Trans Fatty Acids	178-194	RELA proto-oncogene, NF-kB subunit	Homo sapiens	63-76
27853933-4	2017	The results showed that the levels of nuclear translocation of NF-kappaB p65 and phosphorylated ERK1/2 were significantly decreased only in non-lipid rafts cells pretreated with trans fatty acid (TFA).	Trans Fatty Acids	178-194	mitogen-activated protein kinase 3	Homo sapiens	96-102
27853933-4	2017	The results showed that the levels of nuclear translocation of NF-kappaB p65 and phosphorylated ERK1/2 were significantly decreased only in non-lipid rafts cells pretreated with trans fatty acid (TFA).	Trans Fatty Acids	196-199	RELA proto-oncogene, NF-kB subunit	Homo sapiens	63-76
27853933-4	2017	The results showed that the levels of nuclear translocation of NF-kappaB p65 and phosphorylated ERK1/2 were significantly decreased only in non-lipid rafts cells pretreated with trans fatty acid (TFA).	Trans Fatty Acids	196-199	mitogen-activated protein kinase 3	Homo sapiens	96-102
27853933-8	2017	Lipid rafts might be a platform for specific receptors such as TLR4 for TFA to activate the pro-inflammation on cell membranes.	Trans Fatty Acids	72-75	toll like receptor 4	Homo sapiens	63-67
27394654-1	2016	High intakes of industrial trans fatty acids (iTFA) increase circulating low density lipoprotein cholesterol (LDL-C) levels, which has implicated iTFA in coronary heart disease (CHD) risk.	Trans Fatty Acids	27-44	component of oligomeric golgi complex 2	Homo sapiens	73-108
27394654-1	2016	High intakes of industrial trans fatty acids (iTFA) increase circulating low density lipoprotein cholesterol (LDL-C) levels, which has implicated iTFA in coronary heart disease (CHD) risk.	Trans Fatty Acids	27-44	component of oligomeric golgi complex 2	Homo sapiens	110-115
27830423-8	2016	The total content of n-3 PUFA was inversely correlated with the total content of 18:1 TFA in colostrum.	Trans Fatty Acids	86-89	pumilio RNA binding family member 3	Homo sapiens	25-29
27751858-0	2016	Meta-regression analysis of the effect of trans fatty acids on low-density lipoprotein cholesterol.	Trans Fatty Acids	42-59	component of oligomeric golgi complex 2	Homo sapiens	63-98
27751858-1	2016	We conducted a meta-regression of controlled clinical trial data to investigate quantitatively the relationship between dietary intake of industrial trans fatty acids (iTFA) and increased low-density lipoprotein cholesterol (LDL-C).	Trans Fatty Acids	149-166	component of oligomeric golgi complex 2	Homo sapiens	188-223
27751858-1	2016	We conducted a meta-regression of controlled clinical trial data to investigate quantitatively the relationship between dietary intake of industrial trans fatty acids (iTFA) and increased low-density lipoprotein cholesterol (LDL-C).	Trans Fatty Acids	149-166	component of oligomeric golgi complex 2	Homo sapiens	225-230
27583358-12	2016	Diets with frequent pizza and pasta consumption were high in energy, saturated fatty acids, trans-fatty acids, sodium and low in other antioxidants.	Trans Fatty Acids	92-109	solute carrier family 45 member 1	Homo sapiens	30-35
27558396-2	2016	We hypothesized that a beverage high in TFAs would cause a larger reduction in postprandial endothelial function and an increase in arterial stiffness, in part from greater reductions in insulin sensitivity, compared with a beverage high in SFAs.	Trans Fatty Acids	40-44	insulin	Homo sapiens	187-194
27558396-6	2016	A beverage high in TFAs but not SFAs results in a postprandial reduction in endothelial function and a trend for decreased insulin sensitivity, potentially explaining the higher risk of CVD with a diet high in TFAs.	Trans Fatty Acids	19-23	insulin	Homo sapiens	123-130
27558396-6	2016	A beverage high in TFAs but not SFAs results in a postprandial reduction in endothelial function and a trend for decreased insulin sensitivity, potentially explaining the higher risk of CVD with a diet high in TFAs.	Trans Fatty Acids	210-214	insulin	Homo sapiens	123-130
27195698-9	2016	Immunodetection revealed that breast milk from the TFA group showed smaller-sized apoA-I (25.5 +- 0.6 kDa) than that from the control group (27.5 +- 1.5 kDa), whereas formula did not contain apoA-I.	Trans Fatty Acids	51-54	apolipoprotein A-Ia	Danio rerio	82-88
27464460-0	2016	The effects of trans-fatty acids on TAG regulation in mice depend on dietary unsaturated fatty acids.	Trans Fatty Acids	15-32	temporal alpha-galactosidase	Mus musculus	36-39
27464460-1	2016	The aim of this study was to investigate the effects of trans-fatty acids (TFA) on liver and serum TAG regulation in mice fed diets containing different proportions of n-3, n-6 and n-9 unsaturated fatty acids (UFA) from olive (O), maize (C) or rapeseed (R) oils partially substituted or not with TFA (Ot, Ct and Rt, respectively).	Trans Fatty Acids	75-78	temporal alpha-galactosidase	Mus musculus	99-102
27464460-5	2016	In liver, TFA induced an increase in TAG content in the Ot and Rt groups, and this effect was associated with an imbalance between lipogenesis and beta-oxidation.	Trans Fatty Acids	10-13	temporal alpha-galactosidase	Mus musculus	37-40
27464460-8	2016	In brief, the effects of low levels of TFA on liver and serum TAG regulation in mice depend on the dietary proportions of n-3, n-6 and n-9 UFA.	Trans Fatty Acids	39-42	temporal alpha-galactosidase	Mus musculus	62-65
27099924-4	2016	We assessed whether consumption of dietary TFAs modifies HDL-carried miR-223-3p and miR-135a-3p concentration and the inter-relationship between diet-induced changes in HDL-carried miRNA concentration and CVD risk markers.	Trans Fatty Acids	43-47	microRNA 223	Homo sapiens	69-76
27195698-9	2016	Immunodetection revealed that breast milk from the TFA group showed smaller-sized apoA-I (25.5 +- 0.6 kDa) than that from the control group (27.5 +- 1.5 kDa), whereas formula did not contain apoA-I.	Trans Fatty Acids	51-54	apolipoprotein A-Ia	Danio rerio	191-197
27195698-11	2016	CONCLUSIONS: Breast milk from the TFA group showed increased TG and loss of cholesterol, lactalbumin (14 kDa), and apoA-I proteins, resulting in functional impairment of development and growth.	Trans Fatty Acids	34-37	apolipoprotein A-Ia	Danio rerio	115-121
27248994-0	2016	Trans-Fatty Acids Aggravate Obesity, Insulin Resistance and Hepatic Steatosis in C57BL/6 Mice, Possibly by Suppressing the IRS1 Dependent Pathway.	Trans Fatty Acids	0-17	insulin receptor substrate 1	Mus musculus	123-127
27248994-11	2016	These results support our hypothesis that consumption of a diet high in trans-fatty acids induces higher rates of obesity, IR and hepatic steatosis in male C57BL/6 mice, possibly by suppressing the IRS1dependent pathway.	Trans Fatty Acids	72-89	insulin receptor substrate 1	Mus musculus	198-202
26939679-1	2016	Industrially produced partially hydrogenated vegetable fat (PHVF) contains trans fatty acids (TFA) mostly comprising elaidic acid (EA, 18:1 9t).	Trans Fatty Acids	75-92	FAT atypical cadherin 1	Rattus norvegicus	55-58
26939679-1	2016	Industrially produced partially hydrogenated vegetable fat (PHVF) contains trans fatty acids (TFA) mostly comprising elaidic acid (EA, 18:1 9t).	Trans Fatty Acids	94-97	FAT atypical cadherin 1	Rattus norvegicus	55-58
26939679-2	2016	Though, the harmful effects of TFA on health have been repeatedly publicized, the fat containing TFA have been continued to be used as a cooking medium in many regions of the world.	Trans Fatty Acids	97-100	FAT atypical cadherin 1	Rattus norvegicus	82-85
27313848-7	2016	One SNP, rs4654990 near PLA2G2A, with an allele frequency of 0 33, was nominally associated with lower levels of DHA and EPA and higher levels of trans-fatty acids.	Trans Fatty Acids	146-163	phospholipase A2 group IIA	Homo sapiens	24-31
26790695-1	2016	BACKGROUND: Saturated fat (SFA), omega-6 (n-6) polyunsaturated fat (PUFA), and trans fat (TFA) influence risk of coronary heart disease (CHD), but attributable CHD mortalities by country, age, sex, and time are unclear.	Trans Fatty Acids	27-30	FAT atypical cadherin 1	Homo sapiens	22-25
26790695-1	2016	BACKGROUND: Saturated fat (SFA), omega-6 (n-6) polyunsaturated fat (PUFA), and trans fat (TFA) influence risk of coronary heart disease (CHD), but attributable CHD mortalities by country, age, sex, and time are unclear.	Trans Fatty Acids	68-72	FAT atypical cadherin 1	Homo sapiens	63-66
26790695-1	2016	BACKGROUND: Saturated fat (SFA), omega-6 (n-6) polyunsaturated fat (PUFA), and trans fat (TFA) influence risk of coronary heart disease (CHD), but attributable CHD mortalities by country, age, sex, and time are unclear.	Trans Fatty Acids	68-72	FAT atypical cadherin 1	Homo sapiens	63-66
26404481-8	2015	RESULTS: Individuals with higher ELA or PTSD severity were found to have a poorer diet quality (DASH score: p=0.006 and p=0.003, respectively; aHEI-2010 score: ELA p=0.009), including further consumption of trans fatty acids (ELA p=0.003); the differences were significantly attenuated null after adjusting mainly for education or income and/or race.	Trans Fatty Acids	207-224	apelin receptor early endogenous ligand	Homo sapiens	33-36
26561632-1	2015	BACKGROUND: Adverse effects of industrially produced trans fatty acids (iTFAs) on the risk of coronary artery disease are well documented in the scientific literature; however, effects of naturally occurring trans fatty acids (TFAs) from ruminant animals (rTFA), such as vaccenic acid (VA) and cis-9,trans-11 conjugated linoleic acid (c9,t11-CLA), are less clear.	Trans Fatty Acids	53-70	selectin P ligand	Homo sapiens	342-345
26728928-0	2016	The Associations of C-Reactive Protein with Serum Levels of Polyunsaturated Fatty Acids and Trans Fatty Acids Among Middle-Aged Men from Three Populations.	Trans Fatty Acids	92-109	C-reactive protein	Homo sapiens	20-38
26728928-7	2016	Whites had significant inverse trends between CRP and tertiles of total n-6 FAs (GM 1.20, 0.91 and 0.80; p=0.002) and marine-derived n-3 FAs (GM 1.22, 1.00 and 0.72; p<0.001) but a significant positive trend with TFAs (GM 0.80, 0.95 and 1.15; p=0.007).	Trans Fatty Acids	216-220	C-reactive protein	Homo sapiens	46-49
26728928-9	2016	Japanese Americans had CRP associations with n-3 FAs, n-6 FAs, and TFAs similar to but weaker than Whites.	Trans Fatty Acids	67-71	C-reactive protein	Homo sapiens	23-26
25394793-9	2015	Our findings confirm that provision of n-3 or TFA during development over two generations is able to change the neuronal membrane lipid composition, protecting or impairing the hippocampus, respectively, thus affecting neurothrophic factor expression such as BDNF mRNA.	Trans Fatty Acids	46-49	brain-derived neurotrophic factor	Rattus norvegicus	259-263
26393778-0	2015	Lifelong consumption of trans fatty acids promotes striatal impairments on Na(+)/K(+) ATPase activity and BDNF mRNA expression in an animal model of mania.	Trans Fatty Acids	24-41	brain-derived neurotrophic factor	Rattus norvegicus	106-110
25999428-5	2015	Febuxostat exerted a strong protective effect against NASH development induced by a high-fat diet containing trans fatty acid (HFDT).	Trans Fatty Acids	109-125	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	54-58
26166015-7	2015	Serum TFA level had a positive correlation with body mass index, waist circumference, low-density lipoprotein cholesterol, triglycerides, and apolipoprotein B48, and an inverse correlation with age and high-density lipoprotein cholesterol.	Trans Fatty Acids	6-9	apolipoprotein B	Homo sapiens	142-160
25546502-7	2015	The TFA-activated signal pathways and prothrombogenic phenotypic changes of endothelial cells were inhibited by genetic or pharmacological inactivation of Toll-like receptors 2 and 4.	Trans Fatty Acids	4-7	toll-like receptor 2	Mus musculus	155-182
24364735-1	2014	Our previous study showed that trans-fatty acids can cause apoptosis of endothelial cells through the caspase pathway and the mitochondrial pathway.	Trans Fatty Acids	31-48	caspase 8	Homo sapiens	102-109
26396357-6	2014	The low-level trans fatty acid was mainly by dienes and trienes where as high-level trans was from monoenes of C18.	Trans Fatty Acids	14-30	Bardet-Biedl syndrome 9	Homo sapiens	111-114
24717342-8	2014	Comparison of PO-rich diets with diets rich in trans fatty acids showed significantly higher concentrations of HDL cholesterol and apolipoprotein A-I and significantly lower apolipoprotein B, triacylglycerols, and TC/HDL cholesterol.	Trans Fatty Acids	47-64	apolipoprotein A1	Homo sapiens	131-149
24717342-8	2014	Comparison of PO-rich diets with diets rich in trans fatty acids showed significantly higher concentrations of HDL cholesterol and apolipoprotein A-I and significantly lower apolipoprotein B, triacylglycerols, and TC/HDL cholesterol.	Trans Fatty Acids	47-64	apolipoprotein B	Homo sapiens	174-190
24642786-9	2014	Positive significant associations of palmitic and trans-fatty acids with adiponectin were also observed.	Trans Fatty Acids	50-67	adiponectin, C1Q and collagen domain containing	Homo sapiens	73-84
24636816-8	2014	The major mechanism underlying the increased CVD risk from TFA is an increase in LDL-C and Lp(a) lipoproteins and a decrease in HDL-C; increased inflammation and adverse effects on vascular function have also been shown.	Trans Fatty Acids	59-62	component of oligomeric golgi complex 2	Homo sapiens	81-86
23341188-4	2013	Quantitative real-time reverse transcriptase-polymerase chain reaction and Western blotting analyses showed that the two TFA increased the mRNA and protein expression levels of PCNA, CDK2 and Cyclin E in HUVSMC.	Trans Fatty Acids	121-124	proliferating cell nuclear antigen	Homo sapiens	177-181
24028683-7	2013	The TFA diet significantly elevated interleukin (IL)-6, IL-12p40, IL-23p19 and retinoic acid-related orphan receptor (ROR)gammat mRNA levels in the colons of DSS-treated animals.	Trans Fatty Acids	4-7	interleukin 6	Mus musculus	36-54
24028683-7	2013	The TFA diet significantly elevated interleukin (IL)-6, IL-12p40, IL-23p19 and retinoic acid-related orphan receptor (ROR)gammat mRNA levels in the colons of DSS-treated animals.	Trans Fatty Acids	4-7	interleukin 12b	Mus musculus	56-64
24028683-7	2013	The TFA diet significantly elevated interleukin (IL)-6, IL-12p40, IL-23p19 and retinoic acid-related orphan receptor (ROR)gammat mRNA levels in the colons of DSS-treated animals.	Trans Fatty Acids	4-7	interleukin 23, alpha subunit p19	Mus musculus	66-74
24028683-8	2013	Moreover, IL-17A mRNA levels were elevated significantly by the TFA diet, with or without DSS treatment.	Trans Fatty Acids	64-67	interleukin 17A	Mus musculus	10-16
24028683-11	2013	IL-23p19 mRNA levels were increased significantly by TFAs in the absence of LPS.	Trans Fatty Acids	53-57	interleukin 23, alpha subunit p19	Mus musculus	0-8
23333092-9	2013	The C18 unsaturated fatty acids reduced trans fatty acids in the heart, liver and skeletal muscle with lowered stearoyl-CoA desaturase-1 activity index; linoleic and alpha-linolenic acids increased accumulation of their C22 elongated products.	Trans Fatty Acids	40-57	stearoyl-CoA desaturase	Rattus norvegicus	111-136
23341188-4	2013	Quantitative real-time reverse transcriptase-polymerase chain reaction and Western blotting analyses showed that the two TFA increased the mRNA and protein expression levels of PCNA, CDK2 and Cyclin E in HUVSMC.	Trans Fatty Acids	121-124	cyclin dependent kinase 2	Homo sapiens	183-187
23341188-5	2013	Moreover, gas chromatography analysis showed that the total PUFA level of HUVSMC was lower after treatment with the two TFA, especially n-3 PUFA.	Trans Fatty Acids	120-123	pumilio RNA binding family member 3	Homo sapiens	60-64
23341188-5	2013	Moreover, gas chromatography analysis showed that the total PUFA level of HUVSMC was lower after treatment with the two TFA, especially n-3 PUFA.	Trans Fatty Acids	120-123	pumilio RNA binding family member 3	Homo sapiens	140-144
23341188-6	2013	These results suggested that linolelaidic acid exhibited a stronger proliferative effect on HUVSMC than elaidic acid, and regulation of CDK2 and Cyclin E may be important for the effect of the TFA on atherosclerosis.	Trans Fatty Acids	193-196	cyclin dependent kinase 2	Homo sapiens	136-140
22821174-1	2013	Intake of trans fatty acids (TFA) may influence systemic inflammation, insulin resistance and adiposity, but whether TFA intake influences cancer risk is insufficiently studied.	Trans Fatty Acids	10-27	insulin	Homo sapiens	71-78
22821174-1	2013	Intake of trans fatty acids (TFA) may influence systemic inflammation, insulin resistance and adiposity, but whether TFA intake influences cancer risk is insufficiently studied.	Trans Fatty Acids	29-32	insulin	Homo sapiens	71-78
23594856-4	2013	RESULTS: Supplementation of an olive oil-rich diet with TFA increased liver triacylglycerols, the activity and expression of lipogenic enzymes and sterol regulatory element-binding protein SREBP-1a expression.	Trans Fatty Acids	56-59	sterol regulatory element binding transcription factor 1	Mus musculus	189-197
24035019-11	2013	Expression of IL1beta and ICAM1 decreased with increasing TFA.	Trans Fatty Acids	58-61	intercellular adhesion molecule 1	Bos taurus	26-31
23509418-1	2013	The ingestion of excessive amounts of saturated fatty acids (SFAs) and transfatty acids (TFAs) is considered to be a risk factor for cardiovascular diseases, insulin resistance, dyslipidemia, and obesity.	Trans Fatty Acids	71-87	insulin	Homo sapiens	158-165
23509418-1	2013	The ingestion of excessive amounts of saturated fatty acids (SFAs) and transfatty acids (TFAs) is considered to be a risk factor for cardiovascular diseases, insulin resistance, dyslipidemia, and obesity.	Trans Fatty Acids	89-93	insulin	Homo sapiens	158-165
24035019-11	2013	Expression of IL1beta and ICAM1 decreased with increasing TFA.	Trans Fatty Acids	58-61	interleukin 1 beta	Bos taurus	14-21
23368924-0	2013	Trans fatty acids affect cellular viability of human intestinal Caco-2 cells and activate peroxisome proliferator-activated receptors.	Trans Fatty Acids	0-17	peroxisome proliferator activated receptor alpha	Homo sapiens	90-133
23368924-5	2013	In addition to the cytotoxicity studies, the TFA isomers were tested for their ability to activate peroxisome proliferator-activated receptors (PPAR) by taking advantage of a PPAR-dependent reporter gene assay.	Trans Fatty Acids	45-48	peroxisome proliferator activated receptor alpha	Homo sapiens	99-142
23368924-5	2013	In addition to the cytotoxicity studies, the TFA isomers were tested for their ability to activate peroxisome proliferator-activated receptors (PPAR) by taking advantage of a PPAR-dependent reporter gene assay.	Trans Fatty Acids	45-48	peroxisome proliferator activated receptor alpha	Homo sapiens	144-148
23368924-7	2013	The putative impact of TFA on colon cancer development with respect to PPARdelta activation is being discussed.	Trans Fatty Acids	23-26	peroxisome proliferator activated receptor delta	Homo sapiens	71-80
22570091-0	2012	Trans fatty acid intake is associated with insulin sensitivity but independently of inflammation.	Trans Fatty Acids	0-16	insulin	Homo sapiens	43-50
23053553-1	2012	BACKGROUND: Although evidence from cohort studies has suggested that trans fatty acid (TFA) consumption may be associated with insulin resistance and diabetes, randomized placebo-controlled trials (RCTs) have yielded conflicting results.	Trans Fatty Acids	69-85	insulin	Homo sapiens	127-134
23053553-1	2012	BACKGROUND: Although evidence from cohort studies has suggested that trans fatty acid (TFA) consumption may be associated with insulin resistance and diabetes, randomized placebo-controlled trials (RCTs) have yielded conflicting results.	Trans Fatty Acids	87-90	insulin	Homo sapiens	127-134
22209004-5	2012	Moreover, our results show that oligomerization and aggregation of Abeta are increased by trans fatty acids.	Trans Fatty Acids	90-107	amyloid beta precursor protein	Homo sapiens	67-72
22684911-7	2012	Both TFA and stearic acid increased phosphorylation of the ICAM-1 transcriptional regulator, nuclear factor-kappabeta (NF-kappabeta), while oleic and linoleic acids did not appear to alter the phosphorylation status.	Trans Fatty Acids	5-8	intercellular adhesion molecule 1	Homo sapiens	59-65
23077615-5	2012	To test the interaction between total erythrocyte PUFA (ePUFA) and TFA (eTFA) on lipid concentrations we distributed eTFA into tertiles and dichotomized ePUFA at the median concentration.	Trans Fatty Acids	67-70	electron transfer flavoprotein subunit alpha	Homo sapiens	72-76
21543208-0	2012	Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NFkappaBp65 signaling in adult offspring.	Trans Fatty Acids	10-27	toll-like receptor 4	Rattus norvegicus	98-102
22684911-7	2012	Both TFA and stearic acid increased phosphorylation of the ICAM-1 transcriptional regulator, nuclear factor-kappabeta (NF-kappabeta), while oleic and linoleic acids did not appear to alter the phosphorylation status.	Trans Fatty Acids	5-8	nuclear factor kappa B subunit 1	Homo sapiens	119-131
22078008-9	2011	2-factor ANOVA indicated that the TFA diet induced over twice as many cardiac differentially expressed genes (DEGs) in males compared to females (P < 0.001); and 4 times as many male DEGs were downregulated including Gata4, Mef2d and Srebf2.	Trans Fatty Acids	34-37	GATA binding protein 4	Mus musculus	220-225
22078008-9	2011	2-factor ANOVA indicated that the TFA diet induced over twice as many cardiac differentially expressed genes (DEGs) in males compared to females (P < 0.001); and 4 times as many male DEGs were downregulated including Gata4, Mef2d and Srebf2.	Trans Fatty Acids	34-37	myocyte enhancer factor 2D	Mus musculus	227-232
22078008-9	2011	2-factor ANOVA indicated that the TFA diet induced over twice as many cardiac differentially expressed genes (DEGs) in males compared to females (P < 0.001); and 4 times as many male DEGs were downregulated including Gata4, Mef2d and Srebf2.	Trans Fatty Acids	34-37	sterol regulatory element binding factor 2	Mus musculus	237-243
21397284-0	2011	Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women.	Trans Fatty Acids	10-26	insulin	Homo sapiens	37-44
21912103-6	2011	Further, TFA ingestion increased adipose tissue retinol-binding protein 4 mRNA as compared to PUFAs (n-6 or n-3).	Trans Fatty Acids	9-12	retinol binding protein 4	Rattus norvegicus	48-73
22164125-8	2011	The t9/t11 index could be used as an indicator to determine ruminant fat.Practical applications: A number of studies provide evidence that a high TFA intake, particularly of industrial origin, adversely affects human health.	Trans Fatty Acids	146-149	CD2 molecule	Homo sapiens	7-10
22164125-15	2011	Therefore, the t9/t11 index imparts important information on the source of TFA in processed foods.	Trans Fatty Acids	75-78	CD2 molecule	Homo sapiens	18-21
22332075-1	2011	There are 2 predominant sources of dietary trans fatty acids (TFA) in the food supply, those formed during the industrial partial hydrogenation of vegetable oils (iTFA) and those formed by biohydrogenation in ruminants (rTFA), including vaccenic acid (VA) and the naturally occurring isomer of conjugated linoleic acid, cis-9, trans-11 CLA (c9,t11-CLA).	Trans Fatty Acids	43-60	complement C9	Homo sapiens	341-351
22332075-1	2011	There are 2 predominant sources of dietary trans fatty acids (TFA) in the food supply, those formed during the industrial partial hydrogenation of vegetable oils (iTFA) and those formed by biohydrogenation in ruminants (rTFA), including vaccenic acid (VA) and the naturally occurring isomer of conjugated linoleic acid, cis-9, trans-11 CLA (c9,t11-CLA).	Trans Fatty Acids	62-65	complement C9	Homo sapiens	341-351
22813572-5	2011	Industrial TFA poses severe effects on our health like cardiovascular problems, insulin resistance, infertility in women, compromised fetal development and cognitive decline.	Trans Fatty Acids	11-14	insulin	Homo sapiens	80-87
21397284-10	2011	A study population with a stronger predisposition to insulin resistance and/or a longer duration of exposure may be required for insulin sensitivity to be affected by intake of industrial TFA.	Trans Fatty Acids	188-191	insulin	Homo sapiens	53-60
21397284-10	2011	A study population with a stronger predisposition to insulin resistance and/or a longer duration of exposure may be required for insulin sensitivity to be affected by intake of industrial TFA.	Trans Fatty Acids	188-191	insulin	Homo sapiens	129-136
20650350-8	2010	Elevated plasma insulin-like growth factor-1 in mice consuming TFA-enriched milk (P = .02) may contribute to later catch-up growth and leanness and preserved peripheral insulin sensitivity observed in these mice.	Trans Fatty Acids	63-66	insulin-like growth factor 1	Mus musculus	16-44
21208487-1	2011	Trans-fatty acids (TFA) and cis-monounsaturated fat appear to exert detrimental and beneficial effects, respectively, on glucose metabolism and insulin sensitivity.	Trans Fatty Acids	0-17	insulin	Homo sapiens	144-151
21208487-1	2011	Trans-fatty acids (TFA) and cis-monounsaturated fat appear to exert detrimental and beneficial effects, respectively, on glucose metabolism and insulin sensitivity.	Trans Fatty Acids	19-22	insulin	Homo sapiens	144-151
21673371-0	2011	Trans fatty acids induce a proinflammatory response in endothelial cells through ROS-dependent nuclear factor-kappaB activation.	Trans Fatty Acids	0-17	nuclear factor kappa B subunit 1	Homo sapiens	95-116
21673371-13	2011	CONCLUSION: TFAs present in our diet have a direct proinflammatory effect, which promotes leukocyte adhesion to the endothelium through ROS-dependent NF-kappaB activation.	Trans Fatty Acids	12-16	nuclear factor kappa B subunit 1	Homo sapiens	150-159
20799701-3	2010	Results showed that TFA diet significantly enhanced hepatic activity and mRNA expression of fatty acid synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, stearoyl-CoA desaturase-1, and SREBP-1c (P<0.05); however, the intake of PCA significantly diminished the activity and mRNA expression of these lipogenic factors and decreased hepatic lipid accumulation (P<0.05).	Trans Fatty Acids	20-23	stearoyl-Coenzyme A desaturase 1	Mus musculus	162-187
20799701-3	2010	Results showed that TFA diet significantly enhanced hepatic activity and mRNA expression of fatty acid synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, stearoyl-CoA desaturase-1, and SREBP-1c (P<0.05); however, the intake of PCA significantly diminished the activity and mRNA expression of these lipogenic factors and decreased hepatic lipid accumulation (P<0.05).	Trans Fatty Acids	20-23	sterol regulatory element binding transcription factor 1	Mus musculus	193-201
20978530-1	2011	The possible relationship between consumption of trans fatty acids (TFAs) and risk of insulin resistance or development of diabetes mellitus type II has been considered by a number of human and animal studies over the past decade.	Trans Fatty Acids	49-66	insulin	Homo sapiens	86-93
20978530-1	2011	The possible relationship between consumption of trans fatty acids (TFAs) and risk of insulin resistance or development of diabetes mellitus type II has been considered by a number of human and animal studies over the past decade.	Trans Fatty Acids	68-72	insulin	Homo sapiens	86-93
21228440-8	2010	In addition, it appears that TFA consumption may be associated with the development of insulin resistance and type 2 diabetes.	Trans Fatty Acids	29-32	insulin	Homo sapiens	87-94
19822033-9	2009	HAEC treated with TFA (trans-18 : 2) showed significantly increased expression of intracellular adhesion molecule-1 and nitrosylation of cellular proteins than those treated with DHA (n-3 PUFA, 22 : 6).	Trans Fatty Acids	18-21	pumilio RNA binding family member 3	Homo sapiens	188-192
20027500-0	2009	Trans fatty acid intake among the population of the city of Sao Paulo, Brazil.	Trans Fatty Acids	0-16	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	60-63
19474135-2	2009	Epidemiologic data suggest that chronic consumption of industrial sources of TFAs could be damaging to insulin sensitivity, but intervention studies on this issue have remained inconclusive.	Trans Fatty Acids	77-81	insulin	Homo sapiens	103-110
19001666-12	2009	Levels of Ppargc1a were further reduced to 25% by TFA+MSG treatment.	Trans Fatty Acids	50-53	PPARG coactivator 1 alpha	Homo sapiens	10-18
19474135-3	2009	OBJECTIVE: The trial was designed to compare the effects of dairy compared with industrial sources of TFAs on insulin sensitivity in overweight women.	Trans Fatty Acids	102-106	insulin	Homo sapiens	110-117
19399016-4	2009	TFA consumption causes metabolic dysfunction: it adversely affects circulating lipid levels, triggers systemic inflammation, induces endothelial dysfunction, and, according to some studies, increases visceral adiposity, body weight, and insulin resistance.	Trans Fatty Acids	0-3	insulin	Homo sapiens	237-244
19399016-6	2009	Among dietary fats and nutrients, TFAs seem to have a unique cardiometabolic imprint that is linked to insulin-resistance and metabolic-syndrome pathways.	Trans Fatty Acids	34-38	insulin	Homo sapiens	103-110
19424218-7	2009	TFA may also worsen insulin sensitivity, particularly among individuals predisposed to insulin resistance; possible effects on weight gain and diabetes incidence require further confirmation.	Trans Fatty Acids	0-3	insulin	Homo sapiens	20-27
19584878-11	2009	These findings imply that trans-fatty acids may alter nutrient handling in liver, adipose tissue, and skeletal muscle and that the mechanism by which trans-fatty acids induce insulin resistance differs from diets enriched with saturated fats.	Trans Fatty Acids	150-167	insulin	Homo sapiens	175-182
19424218-7	2009	TFA may also worsen insulin sensitivity, particularly among individuals predisposed to insulin resistance; possible effects on weight gain and diabetes incidence require further confirmation.	Trans Fatty Acids	0-3	insulin	Homo sapiens	87-94
19032965-5	2009	Taken together, the evidence suggests that replacing saturated fats and trans fatty acids with unsaturated (polyunsaturated and/or monounsaturated) fats has beneficial effects on insulin sensitivity and is likely to reduce risk of type 2 diabetes.	Trans Fatty Acids	72-89	insulin	Homo sapiens	179-186
19926927-7	2009	IFN-gamma, but not IL-4, production was significantly greater in TFA-fed mice that in control mice.	Trans Fatty Acids	65-68	interferon gamma	Mus musculus	0-9
19056238-7	2009	Trans fatty acid intake, vitamin A intake, and smoking time showed positive and significant correlations with RBP4 concentrations (P < 0.05).	Trans Fatty Acids	0-16	retinol binding protein 4	Homo sapiens	110-114
18053997-4	2008	The basis of our inquiry derives from the facts that the PPAR-gamma receptor plays a pivotal role in placental function and that TFAs down-regulate PPAR-gamma gene mRNA expression.	Trans Fatty Acids	129-133	peroxisome proliferator activated receptor gamma	Homo sapiens	148-158
18996687-4	2008	More limited but growing evidence suggests that TFA also exacerbate visceral adiposity and insulin resistance.	Trans Fatty Acids	48-51	insulin	Homo sapiens	91-98
18053997-11	2008	CONCLUSION(S): Since PPAR-gamma plays a pivotal role in placental biology and is down-regulated by TFAs, TFAs may be a reversible risk factor for fetal loss.	Trans Fatty Acids	99-103	peroxisome proliferator activated receptor gamma	Homo sapiens	21-31
18053997-11	2008	CONCLUSION(S): Since PPAR-gamma plays a pivotal role in placental biology and is down-regulated by TFAs, TFAs may be a reversible risk factor for fetal loss.	Trans Fatty Acids	105-109	peroxisome proliferator activated receptor gamma	Homo sapiens	21-31
33467800-3	2008	Replacement for TFA functionality requires incorporation of plastic and stable saturated fats; the present options are palm or fully hydrogenated oils.	Trans Fatty Acids	16-19	chromosome 10 open reading frame 90	Homo sapiens	89-93
18997461-6	2008	RESULTS: The 4-day increased consumption of C18:1 TFAs led to a significant decrease in mitogen-induced CD69 expression on CD8+ T cells as well as decreased phagocytic activity on neutrophils.	Trans Fatty Acids	50-54	CD69 molecule	Homo sapiens	104-108
18377789-1	2007	Evidence from randomized controlled trials indicates that consumption of trans fatty acids (TFA) leads to harmful changes in serum lipids, systemic inflammation, endothelial function, and, in nonhuman primates, visceral adiposity and insulin resistance.	Trans Fatty Acids	73-90	insulin	Homo sapiens	234-241
17640281-2	2008	TFA may interfere with the metabolism of long-chain polyunsaturated fatty acids (LC-PUFA).	Trans Fatty Acids	0-3	pumilio RNA binding family member 3	Homo sapiens	84-88
17640281-11	2008	The contents of total essential fatty acids and PUFA n-6 were inversely correlated with TFA in colostrum and mature milk.	Trans Fatty Acids	88-91	pumilio RNA binding family member 3	Homo sapiens	48-52
18377789-1	2007	Evidence from randomized controlled trials indicates that consumption of trans fatty acids (TFA) leads to harmful changes in serum lipids, systemic inflammation, endothelial function, and, in nonhuman primates, visceral adiposity and insulin resistance.	Trans Fatty Acids	92-95	insulin	Homo sapiens	234-241
17694343-1	2007	There are multiple adverse effects of trans fatty acids (TFA) that are produced by partial hydrogenation (i.e., manufactured TFA), on CVD, blood lipids, inflammation, oxidative stress, endothelial health, body weight, insulin sensitivity, and cancer.	Trans Fatty Acids	38-55	insulin	Homo sapiens	218-225
17694343-1	2007	There are multiple adverse effects of trans fatty acids (TFA) that are produced by partial hydrogenation (i.e., manufactured TFA), on CVD, blood lipids, inflammation, oxidative stress, endothelial health, body weight, insulin sensitivity, and cancer.	Trans Fatty Acids	57-60	insulin	Homo sapiens	218-225
16713388-9	2006	Large controlled trials have been required to demonstrate adverse effects of saturated fat on insulin sensitivity, and similar efforts will probably be needed to clarify the effect of TFA on insulin sensitivity.	Trans Fatty Acids	184-187	insulin	Homo sapiens	191-198
17234723-0	2007	Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant.	Trans Fatty Acids	0-16	ribonuclease L	Homo sapiens	88-94
17234723-8	2007	This suggests that among Caucasians, positive association between higher trans-fatty acid consumption and prostate cancer may be modified by the functional RNASEL variant R462Q.	Trans Fatty Acids	73-89	ribonuclease L	Homo sapiens	156-162
16713388-1	2006	Since trans fatty acids (TFA) might interfere with cell membrane functions, there are reasons to believe that high TFA intakes could affect insulin sensitivity and consequently diabetes risk.	Trans Fatty Acids	6-23	insulin	Homo sapiens	140-147
16713753-3	2006	The apparent gap between the epidemiologic findings and effects of TFA on LDL:HDL has been bridged, at least in part, by recent metabolic studies showing effects of TFA on inflammatory factors and other indicators of insulin resistance.	Trans Fatty Acids	165-168	insulin	Homo sapiens	217-224
16713388-1	2006	Since trans fatty acids (TFA) might interfere with cell membrane functions, there are reasons to believe that high TFA intakes could affect insulin sensitivity and consequently diabetes risk.	Trans Fatty Acids	115-118	insulin	Homo sapiens	140-147
16713388-3	2006	Data from controlled intervention studies investigating the effects of TFA on insulin sensitivity are reviewed.	Trans Fatty Acids	71-74	insulin	Homo sapiens	78-85
15998628-9	2005	Dietary SFA downregulated adiponectin and GLUT4 and upregulated LPL, while TFA downregulated PPARgamma and LPL.	Trans Fatty Acids	75-78	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	93-102
16713388-5	2006	However, there is some evidence that TFA could impair insulin sensitivity compared to unsaturated fat in insulin resistant or diabetic individuals.	Trans Fatty Acids	37-40	insulin	Homo sapiens	54-61
16713388-5	2006	However, there is some evidence that TFA could impair insulin sensitivity compared to unsaturated fat in insulin resistant or diabetic individuals.	Trans Fatty Acids	37-40	insulin	Homo sapiens	105-112
16713388-6	2006	This is especially true for conjugated TFA, i.e. conjugated linoleic acid (CLA), which clearly impairs insulin sensitivity.	Trans Fatty Acids	39-42	insulin	Homo sapiens	103-110
15998628-11	2005	CONCLUSION: The effects of SFAs on the aforementioned genes except PPARgamma could be extrapolated towards decreased insulin sensitivity, while only the alteration in the mRNA levels of PPARgamma and resistin could be associated with insulin resistance in TFA-fed rats.	Trans Fatty Acids	256-259	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	186-195
15998628-9	2005	Dietary SFA downregulated adiponectin and GLUT4 and upregulated LPL, while TFA downregulated PPARgamma and LPL.	Trans Fatty Acids	75-78	lipoprotein lipase	Rattus norvegicus	107-110
15998628-10	2005	The effects of dietary TFA on PPARgamma and resistin were not counteracted by increased LA (TFA diet 2).	Trans Fatty Acids	23-26	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	30-39
15766276-3	2005	In this study, we examined the molecular interaction of TFA-derived phospholipid with cholesterol and the membrane receptor rhodopsin in model membranes.	Trans Fatty Acids	56-59	rhodopsin	Homo sapiens	124-133
15766276-9	2005	TFA phospholipid membranes also exhibited a higher acyl chain packing order, which was indicated by the lower acyl chain packing free volume as determined by DPH fluorescence and the higher transition temperature for rhodopsin thermal denaturation.	Trans Fatty Acids	0-3	rhodopsin	Homo sapiens	217-226
15747738-12	2005	Results indicate that dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.	Trans Fatty Acids	30-47	peroxisome proliferator activated receptor alpha	Bos taurus	131-140
15735094-8	2005	Trans fatty acid intake was positively related to plasma concentration of CRP (P = 0.009), sTNFR-2 (P = 0.002), E-selectin (P = 0.003), sICAM-1 (P = 0.007), and sVCAM-1 (P = 0.001) in linear regression models after controlling for age, BMI, physical activity, smoking status, alcohol consumption, intake of monounsaturated, polyunsaturated, and saturated fatty acids, and postmenopausal hormone therapy.	Trans Fatty Acids	0-16	C-reactive protein	Homo sapiens	74-77
15735094-8	2005	Trans fatty acid intake was positively related to plasma concentration of CRP (P = 0.009), sTNFR-2 (P = 0.002), E-selectin (P = 0.003), sICAM-1 (P = 0.007), and sVCAM-1 (P = 0.001) in linear regression models after controlling for age, BMI, physical activity, smoking status, alcohol consumption, intake of monounsaturated, polyunsaturated, and saturated fatty acids, and postmenopausal hormone therapy.	Trans Fatty Acids	0-16	selectin E	Homo sapiens	112-122
15741053-0	2005	Trans fatty acids alter the lipid composition and size of apoB-100-containing lipoproteins secreted by HepG2 cells.	Trans Fatty Acids	0-17	apolipoprotein B	Homo sapiens	58-62
12888631-0	2003	Dietary trans fatty acids alter the compositions of microsomes and mitochondria and the activities of microsome delta6-fatty acid desaturase and glucose-6-phosphatase in livers of pregnant rats.	Trans Fatty Acids	8-25	fatty acid desaturase 2	Rattus norvegicus	112-140
15159225-6	2004	C-reactive protein concentrations were higher after consumption of the TFA diet than after consumption of the carbohydrate diet, but were not significantly different after consumption of the TFA and TFA+STE diets than after consumption of the LMP diet.	Trans Fatty Acids	71-74	C-reactive protein	Homo sapiens	0-18
15159225-7	2004	Interleukin 6 concentrations were lower after consumption of the oleic acid diet than after consumption of the LMP, TFA, and STE diets.	Trans Fatty Acids	116-119	interleukin 6	Homo sapiens	0-13
15159225-8	2004	E-selectin concentrations were higher after consumption of the TFA diet than after consumption of the carbohydrate diet.	Trans Fatty Acids	63-66	selectin E	Homo sapiens	0-10
15159225-9	2004	Consumption of the TFA but not the TFA+STE diet resulted in higher E-selectin concentrations than did the LMP diet.	Trans Fatty Acids	19-22	selectin E	Homo sapiens	67-77
15051604-9	2004	TFA intake was not associated with IL-6 or CRP concentrations overall but was positively associated with IL-6 and CRP in women with higher body mass index (P for interaction = 0.03 for each).	Trans Fatty Acids	0-3	interleukin 6	Homo sapiens	105-109
15051604-9	2004	TFA intake was not associated with IL-6 or CRP concentrations overall but was positively associated with IL-6 and CRP in women with higher body mass index (P for interaction = 0.03 for each).	Trans Fatty Acids	0-3	C-reactive protein	Homo sapiens	114-117
15333496-0	2004	High incidence of type 2 diabetes in peroxisome proliferator-activated receptor gamma2 Pro12Ala carriers exposed to a high chronic intake of trans fatty acids and saturated fatty acids.	Trans Fatty Acids	141-158	peroxisome proliferator activated receptor gamma	Homo sapiens	37-86
15325692-0	2004	Effect of variation of trans-fatty acid in lactating rats" diet on lipoprotein lipase activity in mammary gland, liver, and adipose tissue.	Trans Fatty Acids	23-39	lipoprotein lipase	Rattus norvegicus	67-85
15325692-2	2004	We investigated the effects of different dietary contents of trans-fatty acid (TFA) on LPL activity in maternal tissues and fatty acid composition in milk.	Trans Fatty Acids	61-77	lipoprotein lipase	Rattus norvegicus	87-90
15325692-2	2004	We investigated the effects of different dietary contents of trans-fatty acid (TFA) on LPL activity in maternal tissues and fatty acid composition in milk.	Trans Fatty Acids	79-82	lipoprotein lipase	Rattus norvegicus	87-90
15325692-8	2004	Although LPL increased in the MG, milk of rats fed TFA-based diets had significant decreases in the percentage of essential fatty acids.	Trans Fatty Acids	51-54	lipoprotein lipase	Rattus norvegicus	9-12
12888631-0	2003	Dietary trans fatty acids alter the compositions of microsomes and mitochondria and the activities of microsome delta6-fatty acid desaturase and glucose-6-phosphatase in livers of pregnant rats.	Trans Fatty Acids	8-25	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	145-166
12221198-5	2002	Clinical studies show that trans fatty acids can increase insulin resistance and that exercise can enhance the rate of adaptation to a high fat diet by increasing the rate of fat oxidation.	Trans Fatty Acids	27-44	insulin	Homo sapiens	58-65
12716661-0	2003	Postprandial effects of dietary trans fatty acids on apolipoprotein(a) and cholesteryl ester transfer.	Trans Fatty Acids	32-49	lipoprotein(a)	Homo sapiens	53-70
10828478-11	2000	Multivariate analyses revealed that lower plasma fibrinogen was associated with low to normal body mass index in women, and with dietary intakes compatible with prudent dietary guidelines in men and women (low intakes of animal protein; trans fatty acids and higher intakes of plant protein; dietary fibre, vitamin E, and iron, and a high dietary P/S ratio).	Trans Fatty Acids	237-254	fibrinogen beta chain	Homo sapiens	49-59
11517736-9	2001	The differential effects of dietary trans fatty acids in these animal models provide another line of evidence that reinforces the significant role of CETP activity in determining the distribution of plasma cholesterol in response to dietary trans fatty acids.	Trans Fatty Acids	36-53	cholesteryl ester transfer protein	Oryctolagus cuniculus	150-154
11517736-9	2001	The differential effects of dietary trans fatty acids in these animal models provide another line of evidence that reinforces the significant role of CETP activity in determining the distribution of plasma cholesterol in response to dietary trans fatty acids.	Trans Fatty Acids	241-258	cholesteryl ester transfer protein	Oryctolagus cuniculus	150-154
11172480-5	2001	Fasting insulin correlated with reported intakes of total fat (r = .50, P < .01), monounsaturated fat (r = .44, P < .01), and saturated fat (r = .49, P < .01), but not with trans fatty acid intake (r = .11, not significant [NS]).	Trans Fatty Acids	182-198	insulin	Homo sapiens	8-15
7669083-4	1995	We hypothesized that CETP could play a role in the effect of trans fatty acids on lipoproteins and measured the activity levels of CETP in serum samples from a 9-week study in which 55 volunteers were fed three controlled diets with different fatty acid profiles.	Trans Fatty Acids	61-78	cholesteryl ester transfer protein	Homo sapiens	21-25
9507242-5	1998	The SFA, PUFA, and TFA samples had relatively high concentrations of stearic acid (18:0), PUFA, and TFA, respectively.	Trans Fatty Acids	19-22	PUFA	Bos taurus	90-94
9507242-5	1998	The SFA, PUFA, and TFA samples had relatively high concentrations of stearic acid (18:0), PUFA, and TFA, respectively.	Trans Fatty Acids	100-103	PUFA	Bos taurus	9-13
24394782-0	1997	The trans fatty acid content of fats in some manufactured foods commonly available in New Zealand.	Trans Fatty Acids	4-20	chromosome 10 open reading frame 90	Homo sapiens	32-36
24394646-7	1997	Palmitic acid effects were largely comparable to the monounsaturated oleic acid in normolipidaemic subjects while trans fatty acids detrimentally increased plasma cholesterol, LDL-cholesterol, lipoprotein Lp(a) and lowered the beneficial HDL-cholesterol.	Trans Fatty Acids	114-131	lipoprotein(a)	Homo sapiens	193-210
9082038-4	1997	Trans fatty acids also elevated lipoprotein (a) [Lp(a)] values relative to all dietary treatments.	Trans Fatty Acids	0-17	lipoprotein(a)	Homo sapiens	49-54
10674359-1	2000	The aim of the present study was to investigate the maternal-fetal transport, incorporation, and effects on liver delta-6 fatty-acid desaturase activity of dietary trans fatty acids in pregnant rats.	Trans Fatty Acids	164-181	fatty acid desaturase 2	Rattus norvegicus	114-143
10674359-8	2000	In conclusion, high intakes of trans fatty acids partially inhibit liver delta-6 fatty-acid desaturase in pregnant rats, which may explain, in part, the low concentrations of docosahexaenoic acid in pregnant and fetal tissues.	Trans Fatty Acids	31-48	fatty acid desaturase 2	Rattus norvegicus	73-102
11237196-9	2000	Saturated and trans fatty acids (TFA) decrease insulin concentration leading to insulin resistance.	Trans Fatty Acids	33-36	insulin	Homo sapiens	47-54
11237196-9	2000	Saturated and trans fatty acids (TFA) decrease insulin concentration leading to insulin resistance.	Trans Fatty Acids	33-36	insulin	Homo sapiens	80-87
10636973-2	2000	OBJECTIVE: We evaluated whether replacing a proportion of saturated fat with vegetable oils in the diet of young children increases trans fatty acid intake.	Trans Fatty Acids	132-148	FAT atypical cadherin 1	Homo sapiens	68-71
9684747-10	1998	These results show that the trans fatty acids decrease high density lipoprotein through their inhibition of lecithin: cholesterol acyltransferase (LCAT) activity, and also alter LCAT"s positional specificity, inducing the formation of more saturated cholesteryl esters, which are more atherogenic.	Trans Fatty Acids	28-45	lecithin-cholesterol acyltransferase	Homo sapiens	108-145
9684747-10	1998	These results show that the trans fatty acids decrease high density lipoprotein through their inhibition of lecithin: cholesterol acyltransferase (LCAT) activity, and also alter LCAT"s positional specificity, inducing the formation of more saturated cholesteryl esters, which are more atherogenic.	Trans Fatty Acids	28-45	lecithin-cholesterol acyltransferase	Homo sapiens	147-151
9684747-10	1998	These results show that the trans fatty acids decrease high density lipoprotein through their inhibition of lecithin: cholesterol acyltransferase (LCAT) activity, and also alter LCAT"s positional specificity, inducing the formation of more saturated cholesteryl esters, which are more atherogenic.	Trans Fatty Acids	28-45	lecithin-cholesterol acyltransferase	Homo sapiens	178-182
9327759-1	1997	Studies that have shown adverse effects of trans-unsaturated fatty acids on plasma lipoprotein (a) [Lp(a)] levels have used levels of trans-fatty acid that are higher than those in the average U.S. diet.	Trans Fatty Acids	134-150	lipoprotein(a)	Homo sapiens	100-105
9327759-2	1997	This study was conducted to clarify the effects on Lp(a) of trans-fatty acids levels commonly found in U.S. diets.	Trans Fatty Acids	60-77	lipoprotein(a)	Homo sapiens	51-56
7661131-7	1995	Studies in hamsters indicate that trans fatty acids have a neutral effect on low-density-lipoprotein (LDL)-receptor activity, LDL-cholesterol production rate, and plasma LDL-cholesterol concentration.	Trans Fatty Acids	34-51	low density lipoprotein receptor	Homo sapiens	77-115
7669083-6	1995	We conclude that the increased activity of CETP may contribute to the rise in LDL cholesterol and the fall in HDL cholesterol seen on diets with high contents of trans fatty acids.	Trans Fatty Acids	162-179	cholesteryl ester transfer protein	Homo sapiens	43-47
8001841-0	1994	Is insulin resistance influenced by dietary linoleic acid and trans fatty acids?	Trans Fatty Acids	62-79	insulin	Homo sapiens	3-10
8001841-6	1994	Therefore, clinical investigations are needed to evaluate if lowering or preventing insulin resistance through diet by increasing arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid, while lowering linoleic acid and decreasing trans fatty acids from the diet, will modify or prevent the development of these diseases.	Trans Fatty Acids	241-258	insulin	Homo sapiens	84-91
8018112-2	1994	One possible mechanism for this effect is that trans fatty acids increase plasma cholesteryl ester transfer protein (CETP) activity.	Trans Fatty Acids	47-64	cholesteryl ester transfer protein	Homo sapiens	81-115
7910281-4	1994	I propose that the TFA in partially hydrogenated fats impair lipoprotein receptors during energy surfeit, leading to hypercholesterolaemia, atherogenesis, obesity, and insulin resistance.	Trans Fatty Acids	19-22	insulin	Homo sapiens	168-175
8018112-2	1994	One possible mechanism for this effect is that trans fatty acids increase plasma cholesteryl ester transfer protein (CETP) activity.	Trans Fatty Acids	47-64	cholesteryl ester transfer protein	Homo sapiens	117-121
8018112-9	1994	We have shown that CETP demonstrates substrate specificity and that the increase in activity with dietary trans fatty acids may contribute to a more atherogenic lipoprotein profile.	Trans Fatty Acids	106-123	cholesteryl ester transfer protein	Homo sapiens	19-23
2051884-6	1991	It is interesting that trans fatty acids increased the activity of plasma lecithin:cholesterol acyltransferase (LCAT) in both SHRSP and WKY rats.	Trans Fatty Acids	23-40	lecithin cholesterol acyltransferase	Rattus norvegicus	74-110
1431574-10	1992	The median level of Lp[a] was 26 mg/l on the saturated fatty acid diet; it increased to 32 mg/l (P less than 0.020) on the oleic acid diet and to 45 mg/l (P less than 0.001) on the trans-fatty acid diet.	Trans Fatty Acids	181-197	lipoprotein(a)	Homo sapiens	20-24
1431574-11	1992	The difference in Lp[a] between the trans-fatty acid and the oleic acid diets was also highly significant (P less than 0.001).	Trans Fatty Acids	36-52	lipoprotein(a)	Homo sapiens	18-22
15539203-0	1990	Dietary trans fatty acids modulate erythrocyte membrane fatty acyl composition and insulin binding in monkeys.	Trans Fatty Acids	8-25	insulin	Homo sapiens	83-90
33819034-0	2021	Different Influences of trans Fatty Acids on the Phospholipase A2 and Arachidonic Acid Metabolic Pathway in Hepatocytes.	Trans Fatty Acids	24-41	phospholipase A2 group IB	Homo sapiens	49-65
35455966-4	2022	CSB-deprived cells are the most sensitive to oxidation and CSA-deprived cells are the most sensitive to the radical-based formation of trans fatty acids (TFA).	Trans Fatty Acids	135-152	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	0-3
34578964-6	2021	Products having more than 2 g of TFA/100 g of fat were considered to have an elevated TFA content.	Trans Fatty Acids	33-36	FAT atypical cadherin 1	Homo sapiens	46-49
34578964-6	2021	Products having more than 2 g of TFA/100 g of fat were considered to have an elevated TFA content.	Trans Fatty Acids	86-89	FAT atypical cadherin 1	Homo sapiens	46-49
34578930-9	2021	Results: In multivariable adjusted linear regression models per SD increment, the non-esterified trans fatty acid conjugated linoleic acid (trans-18:2 CLA) was positively associated with carotid IMT (beta (95% CI): 44.8 (19.2, 70.4), p = 0.025) among participants with, but not without, ASCVD (2.16 (-6.74, 11.5), p = 1.000).	Trans Fatty Acids	97-113	selectin P ligand	Homo sapiens	151-154
35455966-4	2022	CSB-deprived cells are the most sensitive to oxidation and CSA-deprived cells are the most sensitive to the radical-based formation of trans fatty acids (TFA).	Trans Fatty Acids	135-152	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	59-62
35455966-4	2022	CSB-deprived cells are the most sensitive to oxidation and CSA-deprived cells are the most sensitive to the radical-based formation of trans fatty acids (TFA).	Trans Fatty Acids	154-157	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	59-62
35491150-6	2022	Xanthine oxidase (XO) inhibitors also improved kidney damage in a diabetic renal disorder model using KK/Ay mice and liver damage in a NASH model using high-fat, high-sucrose trans fatty acid loading.	Trans Fatty Acids	175-191	xanthine dehydrogenase	Mus musculus	0-16
6312241-7	1983	Aging, sex, diabetes mellitus, alcohol, catecholamines and trans fatty acids and saturated fats can all modulate the delta-6-desaturase enzyme which converts linoleic acid to gamma-linolenic acid.	Trans Fatty Acids	59-76	fatty acid desaturase 2	Homo sapiens	117-135
7431128-6	1980	Although in vitro studies indicated that the percentage of cholesterol esterified in serum was not affected by the presence of dietary trans fatty acids, LCAT activity generally decreased when trans fatty acids were fed to rats for 9 months.	Trans Fatty Acids	193-210	lecithin cholesterol acyltransferase	Rattus norvegicus	154-158
7124253-0	1982	Effect of dietary trans fatty acids on cholinesterase and monoamine oxidase activities in different organs of rats.	Trans Fatty Acids	18-35	butyrylcholinesterase	Rattus norvegicus	39-53
7124253-1	1982	The effect of trans fatty acids and essential fatty acid deficiency upon the activities of cholinesterase and monoamine oxidase in livers, hearts, brains and lungs of rats was studied.	Trans Fatty Acids	14-31	butyrylcholinesterase	Rattus norvegicus	91-105
7345825-7	1981	This study shows that the dietary trans fatty acids are differentially incorporated into the liver microsomal lipids and act as inhibitors for delta 9 and delta 6 desaturases.	Trans Fatty Acids	34-51	fatty acid desaturase 2	Rattus norvegicus	143-174
7191434-2	1980	At 500 ml these changes were significant (control, oleic): rumen acetate 61.6, 60.3%; rumen propionate 19.4, 21.0%; milk fat content of 18:1 trans fatty acid 3.0, 8.0%; and of 18:2 cis fatty acid 2.2, 1.4%.	Trans Fatty Acids	141-157	Weaning weight-maternal milk	Bos taurus	116-120
7191434-3	1980	Feeding hydrogenated vegetable oil containing 13% trans acid at 454 g per cow per day decreased slightly milk fat percentage and elevated plasma cholesterol 190 to 245 mg/100 ml and 18:1 trans fatty acid in milk fat 4.2 to 6.2%.	Trans Fatty Acids	187-203	Weaning weight-maternal milk	Bos taurus	207-211
573784-6	1979	Studies of delta 5 desaturase activity of liver microsomes in selected groups showed an increase in the conversion of 20:3 omega 6 to 20:4 omega 6 as the trans fatty acid level in the diet increased.	Trans Fatty Acids	154-170	fatty acid desaturase 1	Rattus norvegicus	11-29
566221-3	1978	The significant positive correlation for vegetable fat could not always be explained by the effects of total unsaturated components; individual unsaturated components, such as oleic or linoleic fatty acids; or the saturated component; but could be explained by the trans fatty acid component.	Trans Fatty Acids	265-281	FAT atypical cadherin 1	Homo sapiens	51-54