PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 15170848-0 2004 In vitro release of vascular endothelial growth factor from gadolinium-doped biodegradable microspheres. Gadolinium 60-70 vascular endothelial growth factor A Homo sapiens 20-54 15147190-5 2004 This diamine- and gadolinium-substituted derivative of Abeta is shown to have enhanced in vitro binding to Alzheimer"s disease (AD) amyloid plaques and increased in vivo permeability at the blood-brain barrier because of the unique Asp/Glu substitutions. Gadolinium 18-28 amyloid beta (A4) precursor protein Mus musculus 55-60 15068944-9 2004 10(-15) mol gadolinium per PC3 cell). Gadolinium 12-22 chromobox 8 Mus musculus 27-30 15116014-11 2004 Tumor necrosis factor-alpha and microphage inflammatory protein-1alpha protein levels were markedly reduced in the bronchoalveolar lavage of gadolinium-treated animals by enzyme-linked immunosorbent assay. Gadolinium 141-151 tumor necrosis factor Rattus norvegicus 0-27 15116014-13 2004 Gadolinium pretreatment markedly reduces tumor necrosis factor-alpha elaboration, resulting in significant protection against lung ischemia-reperfusion injury. Gadolinium 0-10 tumor necrosis factor Rattus norvegicus 41-68 15122692-3 2004 These two "bookend" T(1) measurements were used to calibrate the equations which were employed to convert the time course of the 2D SPGR signal strength to T(1)-vs.-time, which in turn was used to compute the gadolinium concentration-vs.-time ([C](t)) in the lesion. Gadolinium 209-219 glutathione S-transferase omega 1 Homo sapiens 132-136 15252660-2 2004 In each complex, the copper and gadolinium or dysprosium ions are linked by a double phenoxo bridge and a eta1:eta1:mu trifluoroacetato bridge. Gadolinium 32-42 secreted phosphoprotein 1 Homo sapiens 106-110 15252660-2 2004 In each complex, the copper and gadolinium or dysprosium ions are linked by a double phenoxo bridge and a eta1:eta1:mu trifluoroacetato bridge. Gadolinium 32-42 secreted phosphoprotein 1 Homo sapiens 111-115 15051872-3 2004 In fetal rat calvarial cells, elevating [Ca2+]o and treatment with gadolinium, a nonpermeant CaR agonist, resulted in phosphorylation of the extracellular signal-regulated kinases 1 and 2, Akt, and glycogensynthase kinase 3beta, consistent with signals of cell survival and proliferation. Gadolinium 67-77 calcium-sensing receptor Rattus norvegicus 93-96 15051872-3 2004 In fetal rat calvarial cells, elevating [Ca2+]o and treatment with gadolinium, a nonpermeant CaR agonist, resulted in phosphorylation of the extracellular signal-regulated kinases 1 and 2, Akt, and glycogensynthase kinase 3beta, consistent with signals of cell survival and proliferation. Gadolinium 67-77 mitogen activated protein kinase 3 Rattus norvegicus 141-187 15051872-3 2004 In fetal rat calvarial cells, elevating [Ca2+]o and treatment with gadolinium, a nonpermeant CaR agonist, resulted in phosphorylation of the extracellular signal-regulated kinases 1 and 2, Akt, and glycogensynthase kinase 3beta, consistent with signals of cell survival and proliferation. Gadolinium 67-77 AKT serine/threonine kinase 1 Rattus norvegicus 189-192 14770236-0 2004 NMR relaxometric study of new Gd(III) macrocyclic complexes and their interaction with human serum albumin. Gadolinium 30-32 albumin Homo sapiens 93-106 14711873-9 2004 We show that gadolinium, an antagonist for stretch-activated cation channels, downregulates the expression of ECE1 and a conduction cell marker, Cx40, in ventricular chambers, concurrently with delayed maturation of a ventricular conduction pathway. Gadolinium 13-23 endothelin converting enzyme 1 Gallus gallus 110-114 14627625-6 2004 Immunofluorescence microscopy indicated that gadolinium caused a pronounced decrease in vinculin and phosphotyrosine concentrations at focal adhesions. Gadolinium 45-55 vinculin Homo sapiens 88-96 14625033-0 2003 Decreased levels of CD95 and caspase-8 mRNA in multiple sclerosis patients with gadolinium-enhancing lesions on MRI. Gadolinium 80-90 Fas cell surface death receptor Homo sapiens 20-24 14625033-0 2003 Decreased levels of CD95 and caspase-8 mRNA in multiple sclerosis patients with gadolinium-enhancing lesions on MRI. Gadolinium 80-90 caspase 8 Homo sapiens 29-38 19003215-12 2003 hCaT1 was inhibited by La(3+), Gd(3+) and Cd(2+), whereas Co(2+), Fe(2+), Mn(2+) and Mg(2+) showed no significant effects on the activity. Gadolinium 31-33 solute carrier family 7 member 1 Homo sapiens 0-5 14676048-10 2003 The BPF change was only weakly correlated to the volume of T1-weighted gadolinium-enhancing lesions in scan 1 (r = -0.185). Gadolinium 71-81 calcium activated nucleotidase 1 Homo sapiens 103-109 14625465-1 2003 Tumor-to-brain contrast after gadolinium administration using MP-RAGE and T1-SE scans in patients with primary and secondary brain tumors was significantly higher at 3 T than at 1.5 T. The subjective assessment of cumulative triple-dose 3 Tesla images obtained the best results in the detection of brain metastases compared with other sequences followed by 1.5 T cumulative triple-dose enhanced images. Gadolinium 30-40 long intergenic non-protein coding RNA 914 Homo sapiens 65-69 12909305-3 2003 In MS, recombinant Interferon-beta (rIFNbeta) is effective in reducing gadolinium contrast-enhancing lesions on magnetic resonance imaging and this suggests that it may reduce BBB damage or even restore its integrity by different mechanisms that include interference with both AM and MMP pathways. Gadolinium 71-81 interferon beta 1 Homo sapiens 19-34 12940835-5 2003 Surface expression of CXCR3 by CD4 T cells was downregulated in the group of patients with high lesion load (LL) on T2-weighted images and gadolinium (Gd)-enhancing lesions on T1-weighted images, compared to the group with high LL and no Gd-enhancing lesions, and to the group with low LL, suggesting internalization of CXCR3 due to the release of its chemokine ligand (IP-10/CXCL10) from active MS lesions. Gadolinium 139-149 C-X-C motif chemokine receptor 3 Homo sapiens 22-27 12940835-5 2003 Surface expression of CXCR3 by CD4 T cells was downregulated in the group of patients with high lesion load (LL) on T2-weighted images and gadolinium (Gd)-enhancing lesions on T1-weighted images, compared to the group with high LL and no Gd-enhancing lesions, and to the group with low LL, suggesting internalization of CXCR3 due to the release of its chemokine ligand (IP-10/CXCL10) from active MS lesions. Gadolinium 151-153 C-X-C motif chemokine receptor 3 Homo sapiens 22-27 12909305-3 2003 In MS, recombinant Interferon-beta (rIFNbeta) is effective in reducing gadolinium contrast-enhancing lesions on magnetic resonance imaging and this suggests that it may reduce BBB damage or even restore its integrity by different mechanisms that include interference with both AM and MMP pathways. Gadolinium 71-81 interferon beta 1 Rattus norvegicus 36-44 12804782-5 2003 These results suggest that the binding of Gd(3+) or a related endogenous substance to this site, alone or in cooperation with glutamate binding at a distant site, leads mGluR1alpha to activation. Gadolinium 42-44 glutamate metabotropic receptor 1 Homo sapiens 169-175 12686562-6 2003 The Ca2+ store-operated channels formed upon expression of TRPC3 at limited levels were blocked by gadolinium; the receptor-activated channels formed upon expression of higher levels of TRPC3 were insensitive to gadolinium. Gadolinium 99-109 transient receptor potential cation channel subfamily C member 3 Gallus gallus 59-64 12672827-10 2003 The nonselective Ca2+ channel blocker, lanthanide gadolinium (Gd3+), partially inhibited hTRPM3-mediated Ca2+ entry. Gadolinium 50-60 transient receptor potential cation channel subfamily M member 3 Homo sapiens 89-95 12764062-4 2003 Here we address the in vitro and ex vivo RNA expression profile under one approved therapy of multiple sclerosis, interferon-beta (IFN-beta, Betaseron), by cDNA microarrays and demonstrate that non-responder and responder phenotypes to IFN-beta as assessed by longitudinal gadolinium-enhanced MRI scans and clinical disease activity differ in their ex vivo gene expression profile. Gadolinium 273-283 interferon beta 1 Homo sapiens 114-129 12767094-7 2003 In patients with neoplastic brain lesions, gadolinium enhancement on a magnetic resonance image was correlated with elevated S100beta levels (n = 45 patients; 0.16 +/- 0.1 microg/L; mean +/- standard error of the mean) versus nonenhancing scans (n = 8 patients; 0.069 +/- 0.04 microg/L). Gadolinium 43-53 S100 calcium binding protein B Homo sapiens 125-133 12782573-3 2003 We have developed a novel two-component gadolinium-based MR contrast agent to image the HER-2/neu receptor. Gadolinium 40-50 erb-b2 receptor tyrosine kinase 2 Homo sapiens 88-97 12746290-4 2003 The stretch-induced phosphorylation of CAKbeta was inhibited completely by an intracellular Ca(2+) chelator [1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetrakis(acetoxymethyl ester)] and largely by gadolinium, but only partially by an extracellular Ca(2+) chelator (EGTA). Gadolinium 212-222 protein tyrosine kinase 2 beta Rattus norvegicus 39-46 12729929-7 2003 The addition of Gd(3+) caused a significant increase in the spin-lattice relaxation rate of CLS when compared to the other lanthanide ions tested. Gadolinium 16-18 spindlin 1 Homo sapiens 60-64 12729929-7 2003 The addition of Gd(3+) caused a significant increase in the spin-lattice relaxation rate of CLS when compared to the other lanthanide ions tested. Gadolinium 16-18 cardiolipin synthase 1 Homo sapiens 92-95 12486207-6 2002 In a phase II randomized, placebo-controlled, double-blind trial in multiple sclerosis, 10,000 IU ingested IFN-alpha significantly decreased gadolinium enhancements compared with the placebo group at month 5. Gadolinium 141-151 interferon alpha 1 Homo sapiens 107-116 12493753-3 2003 The models predict that Gd activates Snk, which in turn activates Ea. Gadolinium 24-26 snake Drosophila melanogaster 37-40 12637285-3 2003 We sought to determine the clinical usefulness of gadolinium-enhanced MR ventriculography for assessing CSF flow in patients with various neurologic conditions. Gadolinium 50-60 colony stimulating factor 2 Homo sapiens 104-107 15348476-2 2003 The synthesis of the Gd>(3+)-containing polymer complex was done by conjugating N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA) with poly (styrene-maleic acid) copolymer (SMA), followed by coordinating with Gd(3+). Gadolinium 21-23 survival of motor neuron 1, telomeric Homo sapiens 182-185 12456670-5 2003 By comparison, TRPC6 was blocked to a similar extent by La(3+) or Gd(3+) at micromolar concentrations and showed no potentiation. Gadolinium 66-68 transient receptor potential cation channel subfamily C member 6 Homo sapiens 15-20 12388158-3 2003 Increases in [Ca(2+)](o) or neomycin and Gd(3+) all substantially increased PTHrP secretion in CaR-HEK cells but had no effect on nontransfected cells. Gadolinium 41-43 calcium sensing receptor Homo sapiens 95-98 12559181-7 2003 Gadolinium inhibited elastase-induced upregulation of TNF-mRNA (P < 0.001), TNF production (P<0.001), and attenuated SAPK/JNK, as well as ERK1/2, but not p38-MAPK. Gadolinium 0-10 tumor necrosis factor-like Rattus norvegicus 54-57 12559181-7 2003 Gadolinium inhibited elastase-induced upregulation of TNF-mRNA (P < 0.001), TNF production (P<0.001), and attenuated SAPK/JNK, as well as ERK1/2, but not p38-MAPK. Gadolinium 0-10 tumor necrosis factor-like Rattus norvegicus 79-82 12559181-7 2003 Gadolinium inhibited elastase-induced upregulation of TNF-mRNA (P < 0.001), TNF production (P<0.001), and attenuated SAPK/JNK, as well as ERK1/2, but not p38-MAPK. Gadolinium 0-10 mitogen-activated protein kinase 9 Rattus norvegicus 123-127 12559181-7 2003 Gadolinium inhibited elastase-induced upregulation of TNF-mRNA (P < 0.001), TNF production (P<0.001), and attenuated SAPK/JNK, as well as ERK1/2, but not p38-MAPK. Gadolinium 0-10 mitogen-activated protein kinase 9 Rattus norvegicus 128-131 12559181-7 2003 Gadolinium inhibited elastase-induced upregulation of TNF-mRNA (P < 0.001), TNF production (P<0.001), and attenuated SAPK/JNK, as well as ERK1/2, but not p38-MAPK. Gadolinium 0-10 mitogen activated protein kinase 3 Rattus norvegicus 144-150 12559181-7 2003 Gadolinium inhibited elastase-induced upregulation of TNF-mRNA (P < 0.001), TNF production (P<0.001), and attenuated SAPK/JNK, as well as ERK1/2, but not p38-MAPK. Gadolinium 0-10 mitogen activated protein kinase 14 Rattus norvegicus 160-163 12486207-7 2002 Tumor necrosis factor-alpha and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 195-205 tumor necrosis factor Homo sapiens 0-27 12486207-7 2002 Tumor necrosis factor-alpha and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 195-205 interferon gamma Homo sapiens 32-41 12486207-7 2002 Tumor necrosis factor-alpha and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 195-205 interferon alpha 1 Homo sapiens 171-180 12446024-5 2002 CD5(+) B lymphocytes from patients with active MS correlated significantly with the number of gadolinium-enhancing MRI lesions, and inversely with disease duration. Gadolinium 94-104 CD5 molecule Homo sapiens 0-3 12581487-6 2002 In a phase II randomized, placebo-controlled, double-blind trial in MS, 10,000 IU ingested IFN-alpha significantly decreased gadolinium enhancements compared with the placebo group at month 5. Gadolinium 125-135 interferon alpha 1 Homo sapiens 91-100 12581487-7 2002 Tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 207-217 tumor necrosis factor Homo sapiens 0-27 12468518-12 2002 On univariate analysis, (18)F-FDG PET, T1-weighted MRI gadolinium enhancement (excluding nonenhancing resection cavity), and T2-weighted MRI volumes were significantly predictive of TTP. Gadolinium 55-65 ZFP36 ring finger protein Homo sapiens 182-185 12581487-7 2002 Tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 207-217 tumor necrosis factor Homo sapiens 29-38 12581487-7 2002 Tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 207-217 interferon gamma Homo sapiens 44-53 12581487-7 2002 Tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 207-217 interferon alpha 1 Homo sapiens 183-192 12377328-4 2002 Gadolinium enhancement was analyzed using the Brix pharmacokinetic model to obtain the parameters amplitude and rate of contrast enhancement. Gadolinium 0-10 biogenesis of ribosomes BRX1 Homo sapiens 46-50 12112083-2 2002 The cortisol release induced by the dexamethasone-corticotropin-releasing hormone test was negatively associated with the presence and number of gadolinium-enhancing lesions and positively associated with ventricular size. Gadolinium 145-155 corticotropin releasing hormone Homo sapiens 50-81 11914123-4 2002 RESULTS: Pretreatment of the cells with the Ca2+ chelators BAPTA-AM or EGTA, as well as the Ca2+ influx inhibitor gadolinium, resulted in a partial decrease of the ERK response. Gadolinium 114-124 mitogen-activated protein kinase 1 Homo sapiens 164-167 11976496-5 2002 The complex between gD(285) and the ectodomain of HveA, a gD cellular receptor member of the tumor necrosis factor (TNFR) superfamily, has also been crystallized. Gadolinium 20-22 TNF receptor superfamily member 14 Homo sapiens 50-54 11976496-5 2002 The complex between gD(285) and the ectodomain of HveA, a gD cellular receptor member of the tumor necrosis factor (TNFR) superfamily, has also been crystallized. Gadolinium 20-22 tumor necrosis factor Homo sapiens 93-114 11976496-5 2002 The complex between gD(285) and the ectodomain of HveA, a gD cellular receptor member of the tumor necrosis factor (TNFR) superfamily, has also been crystallized. Gadolinium 20-22 tumor necrosis factor Homo sapiens 116-120 11976496-6 2002 Moreover, insect-cell-expressed selenomethionine-substituted gD(285) has been purified and crystallized alone and in complex with HveA. Gadolinium 61-63 TNF receptor superfamily member 14 Homo sapiens 130-134 12054569-1 2002 The molecular mechanisms of the hepatic transport of B22956/1, a new gadolinium complex from the class of intravascular contrast agents for MRI, which undergoes extensive biliary elimination, were studied. Gadolinium 69-79 UDP glucuronosyltransferase family 1 member A1 Rattus norvegicus 53-61 11834720-9 2002 Moreover, the stress-mediated induction of HIF-1alpha and VEGF was suppressed by gadolinium (a stretch-activated channel inhibitor), wortmannin, and rapamycin (a FRAP inhibitor). Gadolinium 81-91 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 43-53 11834720-9 2002 Moreover, the stress-mediated induction of HIF-1alpha and VEGF was suppressed by gadolinium (a stretch-activated channel inhibitor), wortmannin, and rapamycin (a FRAP inhibitor). Gadolinium 81-91 vascular endothelial growth factor A Rattus norvegicus 58-62 11838793-3 2002 METHODS: Gadolinium-enhanced magnetic resonance images obtained in 18 patients with inherited NF2 from 11 unrelated families were retrospectively analyzed. Gadolinium 9-19 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 94-97 11994364-4 2002 This effect was mediated by CaR because it was mimicked by the receptor agonist gadolinium and neomycin. Gadolinium 80-90 calcium sensing receptor Homo sapiens 28-31 12491298-0 2002 Compartmentalization of a gadolinium complex in the apoferritin cavity: a route to obtain high relaxivity contrast agents for magnetic resonance imaging. Gadolinium 26-36 ferritin heavy chain 1 Homo sapiens 52-63 11882790-4 2002 RESULTS: Tumor-to-brain-contrast after gadolinium administration using statistical evaluation of MP-RAGE scans was significantly higher at 3 tesla (97.5) than at 1.5 tesla (46.3). Gadolinium 39-49 long intergenic non-protein coding RNA 914 Homo sapiens 100-104 11889762-4 2002 Cervical MRI showed 2 gadolinium-enhanced dorsal-dominant lesions in the spinal cord at C 5/6 and C 6/7 disc levels. Gadolinium 22-32 interferon induced protein with tetratricopeptide repeats 1 Homo sapiens 88-103 11867697-6 2002 TaMDR1 was significantly induced by the exposure to lanthanum, gadolinium and ruthenium red, which are known as inhibitors of calcium channels. Gadolinium 63-73 ABC transporter B family member 4 Triticum aestivum 0-6 12572921-3 2002 The purpose of our study was to measure IL-15 levels in the serum and CSF of 21 patients with relapsing-remitting form of MS, 9 with active gadolinium enhancing lesions in MRI, 12 without enhancing MRI lesions and to compare the results with the control group. Gadolinium 140-150 interleukin 15 Homo sapiens 40-45 12572921-6 2002 IL-15 serum levels were highest in patients with active, gadolinium enhancing lesions. Gadolinium 57-67 interleukin 15 Homo sapiens 0-5 11707743-12 2001 A decrease of insulin release by PBMCs was reproduced with plastic-adherent cells and was abolished by depletion of MHC class II+ cells or by addition of 100 microg/ml gadolinium (which inhibits macrophages), but not by cyclosporine. Gadolinium 168-178 insulin Homo sapiens 14-21 12416929-5 2002 We also show that PECAM-1 is significantly over-expressed on lymphocytes in patients with active MRI lesions, when compared to those without gadolinium-enhancing lesions. Gadolinium 141-151 platelet and endothelial cell adhesion molecule 1 Homo sapiens 18-25 11910328-3 2002 RESULTS: High-resolution T1- and T2-weighted spin-echo and/or gradient echo imaging of the posterior fossa should be performed with the use of intravenous gadolinium for maximum contrast between CSF, vessel, and nerve. Gadolinium 155-165 colony stimulating factor 2 Homo sapiens 195-198 11746371-4 2001 In the present study the T cell response to MBP was longitudinally investigated in terms of frequency, epitope specificity, and cytokine production profile in four patients with relapsing-remitting MS enrolled in a gadolinium-enhanced MRI serial study. Gadolinium 215-225 myelin basic protein Homo sapiens 44-47 11563847-4 2001 By fluorophotometer (with mag-fura 2 fluorescent dye) and atomic absorption spectrophotometer, we confirmed that activation of CaSR by neomycin (0.5 mM) or gadolinium (1 mM) reinforced the decrease of [Mg(2+)](i) induced by Mg(2+) removal in the cells cultured in 10 mM Mg(2+)-containing medium. Gadolinium 156-166 calcium-sensing receptor Rattus norvegicus 127-131 11563988-11 2001 Analysis of Chinese hamster ovary cell transfectants revealed that only 3-OST-3(A) and N1-ST3(A) generated gD-binding sites and conveyed susceptibility to infection by HSV-1. Gadolinium 107-109 heparan sulfate-glucosamine 3-sulfotransferase 1 Homo sapiens 72-77 11563988-11 2001 Analysis of Chinese hamster ovary cell transfectants revealed that only 3-OST-3(A) and N1-ST3(A) generated gD-binding sites and conveyed susceptibility to infection by HSV-1. Gadolinium 107-109 tumor-suppressor, HELA cell type Homo sapiens 90-93 11606540-9 2001 An allele-specific interaction between an autoactivating form of Snake (Snk) and a gd allele altered in the protease domain suggests that Gd directly activates Snk in a protease activation cascade. Gadolinium 138-140 snake Drosophila melanogaster 72-75 11606540-9 2001 An allele-specific interaction between an autoactivating form of Snake (Snk) and a gd allele altered in the protease domain suggests that Gd directly activates Snk in a protease activation cascade. Gadolinium 138-140 snake Drosophila melanogaster 160-163 11282166-3 2001 We previously demonstrated that serum sVCAM levels are increased in multiple sclerosis (MS) patients treated with interferon beta 1b (IFNbeta1b), which correlated with a reduction in gadolinium enhancing lesions on magnetic resonance imaging. Gadolinium 183-193 interferon beta 1 Homo sapiens 114-129 11498427-0 2001 Persistence of gadolinium in CSF: a diagnostic pitfall in patients with end-stage renal disease. Gadolinium 15-25 colony stimulating factor 2 Homo sapiens 29-32 11498427-3 2001 Excretion of gadolinium into the CSF was proven in one case by mass spectrometry. Gadolinium 13-23 colony stimulating factor 2 Homo sapiens 33-36 11498427-5 2001 Recognition that these patients may show increased signal intensity in the subarachnoid space because of gadolinium excretion into CSF may prevent diagnostic errors. Gadolinium 105-115 colony stimulating factor 2 Homo sapiens 131-134 11444910-6 2001 The higher TNF-alpha mRNA was evident in patients with gadolinium-enhancing lesions. Gadolinium 55-65 tumor necrosis factor Homo sapiens 11-20 11376181-7 2001 The CD31+ EMP concentration showed a positive association with gadolinium enhancement in patients with MS. Gadolinium 63-73 platelet and endothelial cell adhesion molecule 1 Homo sapiens 4-8 11457182-1 2001 The full series of lanthanide ions (except the radioactive promethium and the S-state gadolinium) has been incorporated into the C-terminal calcium binding site of the dicalcium protein calbindin D(9k). Gadolinium 86-96 S100 calcium binding protein G Homo sapiens 186-200 11551238-2 2001 The purpose of the study was to measure IL-18 levels in serum and CSF of 21 patients with the relapsing-remitting form of MS, 9 with active gadolinium enhancing lesions in MRI and 12 without enhancing lesions, and to compare results with control group consisting of 11 patients with diagnosis of neurasthenia and tension headache. Gadolinium 140-150 interleukin 18 Homo sapiens 40-45 11447088-8 2001 Gadolinium inhibited the activation of HSF and decreased HSP72 mRNA level. Gadolinium 0-10 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 57-62 11169832-2 2001 Twenty patients with hepatocellular carcinoma (HCC) underwent 3DFISP dynamic study with double dose Gd. Gadolinium 100-102 HCC Homo sapiens 47-50 11718386-1 2001 The aim was to evaluate a subtraction technique for breath-hold gadolinium enhanced three-dimensional magnetic resonance portography (3D-MRP). Gadolinium 64-74 ATP binding cassette subfamily C member 1 Homo sapiens 137-140 10964699-5 2000 Basal administration of the CaR agonist gadolinium (30 microm) also stimulated JNK activity. Gadolinium 40-50 calcium sensing receptor Canis lupus familiaris 28-31 11050025-9 2000 The different pattern seen in patients with and without baseline gadolinium enhancement suggests that part of the cerebral volume reduction observed in IFNbeta-treated patients may be due to the anti-inflammatory/antioedematous effect of the drug. Gadolinium 65-75 interferon beta 1 Homo sapiens 152-159 11046067-8 2000 Some clinical relapses were preceded by surges of T cell reactivity to PLP(184-209), and in one patient there was significant correlation between the frequency of T cells reactive to PLP(184-199) and the total number of gadolinium-enhancing magnetic resonance imaging lesions. Gadolinium 220-230 proteolipid protein 1 Homo sapiens 183-186 11006365-8 2000 As compared with the patients in the placebo group, patients in the interferon beta-1a group had a relative reduction in the volume of brain lesions (P<0.001), fewer new or enlarging lesions (P<0.001), and fewer gadolinium-enhancing lesions (P<0.001) at 18 months. Gadolinium 212-222 interferon beta 1 Homo sapiens 68-83 11027507-5 2000 When E1 cells stimulated with agonists of CaSR, gadolinium, and neomycin, OPGL/ODF mRNA expression decreased. Gadolinium 48-58 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 79-82 10842183-5 2000 The sensitivity to pH or amiloride of single versus co-expressed ASIC subunits was not significantly different; however, gadolinium ions inhibited ASIC3 and ASIC2a+3 responses with much higher potency (IC(50) approximately 40 microm) than the ASIC2a response (IC(50) >/=1 mm). Gadolinium 121-131 acid sensing ion channel subunit 3 Homo sapiens 147-152 10842183-5 2000 The sensitivity to pH or amiloride of single versus co-expressed ASIC subunits was not significantly different; however, gadolinium ions inhibited ASIC3 and ASIC2a+3 responses with much higher potency (IC(50) approximately 40 microm) than the ASIC2a response (IC(50) >/=1 mm). Gadolinium 121-131 acid sensing ion channel subunit 2 Homo sapiens 157-163 10842183-5 2000 The sensitivity to pH or amiloride of single versus co-expressed ASIC subunits was not significantly different; however, gadolinium ions inhibited ASIC3 and ASIC2a+3 responses with much higher potency (IC(50) approximately 40 microm) than the ASIC2a response (IC(50) >/=1 mm). Gadolinium 121-131 acid sensing ion channel subunit 2 Homo sapiens 243-249 10842183-7 2000 Our in situ hybridization data showed that rat ASIC2a and ASIC3 transcripts are co-localized centrally, whereas reverse transcription-polymerase chain reaction data led us to detect co-expression of human ASIC2a and ASIC3 subunits in trigeminal sensory ganglia, brain, and testis where they might co-assemble into a novel subtype of proton-gated channels sensitive to gadolinium. Gadolinium 368-378 acid sensing ion channel subunit 2 Homo sapiens 205-211 10842183-7 2000 Our in situ hybridization data showed that rat ASIC2a and ASIC3 transcripts are co-localized centrally, whereas reverse transcription-polymerase chain reaction data led us to detect co-expression of human ASIC2a and ASIC3 subunits in trigeminal sensory ganglia, brain, and testis where they might co-assemble into a novel subtype of proton-gated channels sensitive to gadolinium. Gadolinium 368-378 acid sensing ion channel subunit 3 Homo sapiens 216-221 11734954-1 2001 The aim of this study was to assess in vivo patency of seven commonly used non-ferromagnetic plain stents as regards demonstration of the contained lumen at 3D gadolinium-enhanced MRA in a 0.5-T MR environment. Gadolinium 160-170 serpin family C member 1 Homo sapiens 154-159 11673848-5 2001 GSH-Px activities in VYS decreased after GD 13, ultimately constituting a 37% decrease at GD 21. Gadolinium 41-43 glutathione peroxidase 1 Rattus norvegicus 0-6 11133285-2 2001 In this work, the diffusion coefficients of gadolinium-DTPA and Gd-labeled versions of four proteins-lysozyme, trypsinogen, ovalbumin, and bovine serum albumin (BSA) with molecular weights of 14,300, 24,000, 45,000, and 67,000, respectively-have been measured in healthy and degraded calf cartilage. Gadolinium 64-66 lysozyme C, tracheal isozyme Bos taurus 101-109 11133285-2 2001 In this work, the diffusion coefficients of gadolinium-DTPA and Gd-labeled versions of four proteins-lysozyme, trypsinogen, ovalbumin, and bovine serum albumin (BSA) with molecular weights of 14,300, 24,000, 45,000, and 67,000, respectively-have been measured in healthy and degraded calf cartilage. Gadolinium 64-66 ovalbumin Bos taurus 124-133 11133285-2 2001 In this work, the diffusion coefficients of gadolinium-DTPA and Gd-labeled versions of four proteins-lysozyme, trypsinogen, ovalbumin, and bovine serum albumin (BSA) with molecular weights of 14,300, 24,000, 45,000, and 67,000, respectively-have been measured in healthy and degraded calf cartilage. Gadolinium 64-66 albumin Bos taurus 146-159 11113229-1 2000 CSF volume depletions, whether from leak or shunt overdrainage, typically cause low CSF opening pressures, orthostatic headaches, and diffuse pachymeningeal gadolinium enhancement on MRI. Gadolinium 157-167 colony stimulating factor 2 Homo sapiens 0-3 10828238-11 2000 Inclusion of the stretch-activated cation-channel blocker, gadolinium, enhanced the arterial flow-induced increase in eNOS, but prevented the arterial flow-induced increase in ICAM-1. Gadolinium 59-69 nitric oxide synthase 3 Homo sapiens 118-122 10875492-2 2000 Interleukin-8 in the sputa from GD-induced asthmatic patients increased significantly after the exposure to GD. Gadolinium 32-34 C-X-C motif chemokine ligand 8 Homo sapiens 0-13 10875492-2 2000 Interleukin-8 in the sputa from GD-induced asthmatic patients increased significantly after the exposure to GD. Gadolinium 108-110 C-X-C motif chemokine ligand 8 Homo sapiens 0-13 10875492-3 2000 OBJECTIVE: To confirm IL-8 production from bronchial epithelial cells when exposed to GD, and to evaluate the role of IL-8 on neutrophil recruitment. Gadolinium 86-88 C-X-C motif chemokine ligand 8 Homo sapiens 22-26 10873064-5 2000 The infusion of IL-4-toxin in six of nine patients showed glioma necrosis as evidenced by diminished gadolinium enhancement on magnetic resonance imaging. Gadolinium 101-111 interleukin 4 Homo sapiens 16-20 10827152-7 2000 Reperfused livers from nude or gadolinium pretreated mice disclosed a dramatic decrease in TNF and IFN-gamma release. Gadolinium 31-41 tumor necrosis factor Mus musculus 91-94 10827152-7 2000 Reperfused livers from nude or gadolinium pretreated mice disclosed a dramatic decrease in TNF and IFN-gamma release. Gadolinium 31-41 interferon gamma Mus musculus 99-108 10898310-11 2000 However, gadolinium significantly moderated the ethanol induction of CYP2E1 and this effect correlated to the degree of steatosis. Gadolinium 9-19 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 69-75 10811693-2 2000 INTRODUCTION: Patients with PP or TP MS have been shown to have low brain T2 and T1 lesion loads and slow rates of new lesion formation with minimal gadolinium enhancement, despite their accumulating disability. Gadolinium 149-159 trichoplein keratin filament binding Homo sapiens 34-39 10802778-1 2000 OBJECTIVE: The authors examined the effect of 6.0 MIU interferon beta-1a (IFNbeta-1a) administered IM each week on the evolution of monthly magnetization transfer ratio (MTR) within new gadolinium-enhancing (Gd+) lesions in patients with very early relapsing-remitting (RR) MS. BACKGROUND: IFNbeta is an effective disease-modifying treatment for patients with RRMS. Gadolinium 186-196 interferon beta 1 Homo sapiens 74-81 10828238-11 2000 Inclusion of the stretch-activated cation-channel blocker, gadolinium, enhanced the arterial flow-induced increase in eNOS, but prevented the arterial flow-induced increase in ICAM-1. Gadolinium 59-69 intercellular adhesion molecule 1 Homo sapiens 176-182 10828238-12 2000 CONCLUSIONS: perfusion of veins under arterial flow conditions with gadolinium was associated with low endothelial concentrations of ICAM-1, VCAM-1 and TF, but high levels of eNOS. Gadolinium 68-78 intercellular adhesion molecule 1 Homo sapiens 133-139 10828238-12 2000 CONCLUSIONS: perfusion of veins under arterial flow conditions with gadolinium was associated with low endothelial concentrations of ICAM-1, VCAM-1 and TF, but high levels of eNOS. Gadolinium 68-78 vascular cell adhesion molecule 1 Homo sapiens 141-147 10828238-12 2000 CONCLUSIONS: perfusion of veins under arterial flow conditions with gadolinium was associated with low endothelial concentrations of ICAM-1, VCAM-1 and TF, but high levels of eNOS. Gadolinium 68-78 coagulation factor III, tissue factor Homo sapiens 152-154 10828238-12 2000 CONCLUSIONS: perfusion of veins under arterial flow conditions with gadolinium was associated with low endothelial concentrations of ICAM-1, VCAM-1 and TF, but high levels of eNOS. Gadolinium 68-78 nitric oxide synthase 3 Homo sapiens 175-179 10762092-3 2000 A significant correlation was found in the treated group between serum-soluble endothelial-leukocyte adhesion molecule-1 and the lesion area in the Gadolinium-enhancing (T2 weighted scan) MRI. Gadolinium 148-158 selectin E Homo sapiens 79-120 10718741-14 2000 Gadolinium (Gd3+) acted on INSC,b and ISAC,NC differently. Gadolinium 0-10 INSC, spindle orientation adaptor protein Rattus norvegicus 27-31 10794673-6 2000 5-1 h. Although gadolinium, a mechanosensitive channel blocker, significantly reduced the [Ca(2+)](i) response, neither gadolinium nor nifedipine, an L-type channel Ca(2+) channel blocker, were able to block shear-induced stress fiber formation and increase in c-fos and COX-2 in MC3T3-E1 cells. Gadolinium 16-26 FBJ osteosarcoma oncogene Mus musculus 261-266 10794673-6 2000 5-1 h. Although gadolinium, a mechanosensitive channel blocker, significantly reduced the [Ca(2+)](i) response, neither gadolinium nor nifedipine, an L-type channel Ca(2+) channel blocker, were able to block shear-induced stress fiber formation and increase in c-fos and COX-2 in MC3T3-E1 cells. Gadolinium 16-26 cytochrome c oxidase II, mitochondrial Mus musculus 271-276 10875492-9 2000 RESULTS: Interleukin-8 production and neutrophil chemotactic activity from bronchial epithelial cells significantly increased with additions of GD in a dose-dependent manner (P < .05, respectively), and were significantly augmented with additions of PBMC supernatant (P < .05, respectively) at each concentration. Gadolinium 144-146 C-X-C motif chemokine ligand 8 Homo sapiens 9-22 10875492-12 2000 CONCLUSION: These results suggest that IL-8 produced from bronchial epithelial cells may be a major cytokine, which induces neutrophil migration into the airways when exposed to GD. Gadolinium 178-180 C-X-C motif chemokine ligand 8 Homo sapiens 39-43 10697655-5 2000 CONCLUSIONS: When an equal number of atoms were present, Gd-157 was effective as B-10 when exposed to an equal number of thermal neutrons. Gadolinium 57-59 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 81-85 10767179-0 2000 Studies on human porin XXI: gadolinium opens Up cell membrane standing porin channels making way for the osmolytes chloride or taurine-A putative approach to activate the alternate chloride channel in cystic fibrosis. Gadolinium 28-38 voltage dependent anion channel 1 Homo sapiens 17-22 10767179-0 2000 Studies on human porin XXI: gadolinium opens Up cell membrane standing porin channels making way for the osmolytes chloride or taurine-A putative approach to activate the alternate chloride channel in cystic fibrosis. Gadolinium 28-38 voltage dependent anion channel 1 Homo sapiens 71-76 10767179-9 2000 Together with data on a decreasing effect of micromolar amounts of gadolinium on the voltage dependence of reconstituted human porin the results prove the involvement of porin channels in the swelling behavior in different cell lines. Gadolinium 67-77 voltage dependent anion channel 1 Homo sapiens 127-132 10767179-9 2000 Together with data on a decreasing effect of micromolar amounts of gadolinium on the voltage dependence of reconstituted human porin the results prove the involvement of porin channels in the swelling behavior in different cell lines. Gadolinium 67-77 voltage dependent anion channel 1 Homo sapiens 170-175 10767179-10 2000 As a mechanism we propose that ionic gadolinium opens up plasmalemma-integrated porin channels, chloride or taurine then following their concentration gradients into the cells. Gadolinium 37-47 voltage dependent anion channel 1 Homo sapiens 80-85 10652312-4 2000 In addition, a panel of extracellular cations, including aluminum and the CasR agonists gadolinium and calcium, stimulated DNA synthesis, activated a transfected serum response element-luciferase reporter construct, and inhibited agonist-induced cAMP in CasR(-/-) osteoblasts. Gadolinium 88-98 calcium-sensing receptor Mus musculus 74-78 10697655-4 2000 The presence of B-10 enhanced the radiation effect of Gd-157 neutron capture by 1.2-fold, suggesting that cells were not sufficiently irradiated as a result of neutron fluency attenuation by the presence of excess neutron capture agents in the medium. Gadolinium 54-56 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 16-20 10634928-5 2000 External Ca(2+) chelation (EGTA 4 mM) or administration of Ca(2+) channel inhibitors gadolinium 50 microM or nickel 500 microM inhibited insulin-induced PI 3-kinase activation by 85, 50 and 50%, respectively, whereas 200 microM verapamil was without effect. Gadolinium 85-95 WAP four-disulfide core domain 15B Rattus norvegicus 153-157 10567499-9 1999 The magnitude of caspase-1 mRNA increase correlated with the number of new (p=0.01) but not persisting gadolinium enhancing brain MRI lesions. Gadolinium 103-113 caspase 1 Homo sapiens 17-26 10631637-3 1999 Elevated levels of serum soluble TNF receptors (sTNF-R) are reported in patients with gadolinium enhancing lesions, and animal models suggest a possible therapeutic role of sTNF-RI in MS. Gadolinium 86-96 tumor necrosis factor Homo sapiens 33-36 10602863-1 1999 In this study, we retrospectively reviewed the MRI features of recurrent nasopharyngeal carcinoma (NPC) in 72 patients who underwent MRI before and after gadolinium injection. Gadolinium 154-164 NPC intracellular cholesterol transporter 1 Homo sapiens 99-102 10505971-0 1999 Increased serum levels of soluble PECAM-1 in multiple sclerosis patients with brain gadolinium-enhancing lesions. Gadolinium 84-94 platelet and endothelial cell adhesion molecule 1 Homo sapiens 34-41 10505971-3 1999 We present data showing that soluble PECAM-1 is significantly increased in sera of multiple sclerosis patients with active, gadolinium enhancing lesions. Gadolinium 124-134 platelet and endothelial cell adhesion molecule 1 Homo sapiens 37-44 10388792-0 1999 Spatial mapping of T2 and gadolinium-enhancing T1 lesion volumes in multiple sclerosis: evidence for distinct mechanisms of lesion genesis? Gadolinium 26-36 interleukin 1 receptor like 1 Homo sapiens 47-49 10443690-8 1999 Similar results were obtained with the CaSR activators gadolinium and neomycin. Gadolinium 55-65 calcium sensing receptor Homo sapiens 39-43 10467389-4 1999 Gadolinium-enhancing lesions correlate with the occurrence of relapses, CSF myelin breakdown products and, in patients with relapsing-remitting disease, with higher EDSS. Gadolinium 0-10 colony stimulating factor 2 Homo sapiens 72-75 10430434-1 1999 CSF leak is recognized to cause orthostatic headaches and diffuse pachymeningeal gadolinium enhancement (DPMGE) on MRI. Gadolinium 81-91 colony stimulating factor 2 Homo sapiens 0-3 10400686-5 1999 Functional studies, in which intracellular free Ca2+ concentration was measured in isolated acinar cells and interlobular ducts, show that both cell types are responsive to the CaR agonist gadolinium (Gd3+) and to changes in extracellular Ca2+ concentration. Gadolinium 189-199 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 177-180 10388792-1 1999 It is generally believed that most T2-weighted (T2) lesions in the central white matter of patients with multiple sclerosis begin with a variable period of T1-weighted (T1) gadolinium (Gd) enhancement and that T1 Gd-enhancing and T2 lesions represent stages of a single pathological process. Gadolinium 173-183 solute carrier family 25 member 5 Homo sapiens 35-37 10388792-1 1999 It is generally believed that most T2-weighted (T2) lesions in the central white matter of patients with multiple sclerosis begin with a variable period of T1-weighted (T1) gadolinium (Gd) enhancement and that T1 Gd-enhancing and T2 lesions represent stages of a single pathological process. Gadolinium 173-183 solute carrier family 25 member 5 Homo sapiens 48-50 10388792-1 1999 It is generally believed that most T2-weighted (T2) lesions in the central white matter of patients with multiple sclerosis begin with a variable period of T1-weighted (T1) gadolinium (Gd) enhancement and that T1 Gd-enhancing and T2 lesions represent stages of a single pathological process. Gadolinium 173-183 solute carrier family 25 member 5 Homo sapiens 48-50 10362847-11 1999 In cells in which DOC produced a conductance increase of 1010 +/- 10 pS pF-1, gadolinium (0.5 mM) induced a fall in cell conductance of 1800 +/- 10 pS pF-1. Gadolinium 78-88 PHD finger protein 12 Homo sapiens 72-76 10364318-2 1999 Studies on the interaction of HSV-1 with HveA have shown that of all the viral proteins involved in uptake, only gD has been shown to bind directly to HveA, and this binding mediates viral entry into cells. Gadolinium 113-115 TNF receptor superfamily member 14 Homo sapiens 41-45 10364318-2 1999 Studies on the interaction of HSV-1 with HveA have shown that of all the viral proteins involved in uptake, only gD has been shown to bind directly to HveA, and this binding mediates viral entry into cells. Gadolinium 113-115 TNF receptor superfamily member 14 Homo sapiens 151-155 10364318-3 1999 In addition to gD binding to HveA, the latter has been shown to interact with proteins of tumor necrosis factor receptor-associated factor family, lymphotoxin-alpha (LT-alpha), and a membrane-associated protein referred to as LIGHT. Gadolinium 15-17 TNF receptor superfamily member 14 Homo sapiens 29-33 10362847-11 1999 In cells in which DOC produced a conductance increase of 1010 +/- 10 pS pF-1, gadolinium (0.5 mM) induced a fall in cell conductance of 1800 +/- 10 pS pF-1. Gadolinium 78-88 PHD finger protein 12 Homo sapiens 151-155 9817947-7 1998 The fluid shear stress-induced increase in the TGF-beta1 mRNA levels was significantly inhibited by both gadolinium and verapamil. Gadolinium 105-115 transforming growth factor beta 1 Homo sapiens 47-56 10376955-7 1999 Both plasma and CSF in patients with relapsing/remitting MS and marked gadolinium enhancement contained the two major molecular species of PAF: 1-0-hexadecyl- (C16:O) and 1-0-octadecyl-sn-glycero-3-phosphocholine (C18:O). Gadolinium 71-81 PCNA clamp associated factor Homo sapiens 139-142 9880510-7 1999 Finally, TRAAK is reversibly blocked by micromolar concentrations of gadolinium, a well known blocker of stretch-activated channels. Gadolinium 69-79 potassium two pore domain channel subfamily K member 4 Homo sapiens 9-14 10231437-5 1999 In addition, [Ca2+]i levels and IP1 generation were enhanced in a dose-dependent fashion by additions of the CaSR agonists calcium (Ca2+), magnesium (Mg2+), gadolinium (Gd3+), and neomycin only in cells transfected with CaSR. Gadolinium 157-167 calcium sensing receptor Homo sapiens 109-113 10231437-5 1999 In addition, [Ca2+]i levels and IP1 generation were enhanced in a dose-dependent fashion by additions of the CaSR agonists calcium (Ca2+), magnesium (Mg2+), gadolinium (Gd3+), and neomycin only in cells transfected with CaSR. Gadolinium 157-167 calcium sensing receptor Homo sapiens 220-224 10227335-8 1999 RESULTS: There was significant production of IL-8 from bronchial epithelial cells with additions of GD in a dose-dependent manner (P < .05), which was significantly augmented with additions of PBMC supernatant (P < .05) at each concentration. Gadolinium 100-102 C-X-C motif chemokine ligand 8 Homo sapiens 45-49 10227335-10 1999 CONCLUSION: These results suggest that IL-8 production from bronchial epithelial cells may contribute to neutrophil recruitment occurring in GD-induced airway inflammation. Gadolinium 141-143 C-X-C motif chemokine ligand 8 Homo sapiens 39-43 9824497-7 1998 However, TNF-alpha and IL-2 were crucial in terms of virus clearance from the eyes, since gD3 (three vaccinations with 1 microg of gD), which had less virus in their eyes, had high numbers of TNF-alpha and IL-2 infiltrates. Gadolinium 90-92 tumor necrosis factor Homo sapiens 192-201 9782170-8 1998 Spontaneous activity of c-Kit-LI cells was inhibited by reduced extracellular Na+, gadolinium, and reduced extracellular Ca2+. Gadolinium 83-93 KIT proto-oncogene receptor tyrosine kinase Mus musculus 24-29 9681508-8 1998 Exposure of ST2 cells to high Ca2+(o) (4.8 mM) or to the polycationic CaR agonists, neomycin (300 microM) or gadolinium (100 microM), stimulated both chemotaxis and DNA synthesis in ST2 cells. Gadolinium 109-119 calcium-sensing receptor Mus musculus 70-73 9783541-7 1998 Exposure of MC3T3-E1 cells to high Ca2+o (up to 4.8 mM) or the polycationic CaR agonists, neomycin and gadolinium (Gd3+), stimulated both chemotaxis and DNA synthesis in MC3T3-E1 cells. Gadolinium 103-113 calcium-sensing receptor Mus musculus 76-79 9748027-2 1998 BACKGROUND: CSF leak or shunt overdrainage is known to cause orthostatic headaches and diffuse pachymeningeal gadolinium enhancement (DPGE), typically associated with unmeasurable or very low CSF pressures. Gadolinium 110-120 colony stimulating factor 2 Homo sapiens 12-15 9748027-2 1998 BACKGROUND: CSF leak or shunt overdrainage is known to cause orthostatic headaches and diffuse pachymeningeal gadolinium enhancement (DPGE), typically associated with unmeasurable or very low CSF pressures. Gadolinium 110-120 colony stimulating factor 2 Homo sapiens 192-195 9746905-3 1998 Reducing IK by adding the channel blocker tetraethylammonium (TEA, 5 mM) or raising extracellular K+ to 25 mM attenuated A beta-induced neuronal death, even in the presence of nifedipine or gadolinium to block associated increases in Ca2+ influx. Gadolinium 190-200 amyloid beta precursor protein Homo sapiens 121-127 9649612-6 1998 CD-1 mice were pretreated with saline or Zn (20 and 40 mg/kg) on GD 8.5 and 9.5. Gadolinium 65-67 CD1 antigen complex Mus musculus 0-4 9688807-0 1998 Fat-suppressed gadolinium-enhanced three-dimensional magnetic resonance angiography adequately depicts the status of iliac arteries following atherectomy and stent placement. Gadolinium 15-25 FAT atypical cadherin 1 Homo sapiens 0-3 9754716-2 1998 PLD activation was also analysed by measuring tritiated phosphatidic acid (PA) and diglycerides (GDs) in PMNs labelled with tritiated alkyl-lyso PC. Gadolinium 97-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 22150981-15 1998 Gadolinium enhanced MRI scanning at the catheter tip is the imaging study of choice for diagnosis. Gadolinium 0-10 TOR signaling pathway regulator Homo sapiens 49-52 9603150-8 1998 Fewer numbers of alveolar macrophages expressed iNOS protein after gadolinium pretreatment. Gadolinium 67-77 nitric oxide synthase 2 Rattus norvegicus 48-52 9677137-10 1998 RESULTS: There was a significant increase in the number of AA1+ and NE+ cells in bronchial mucosa of GD-induced asthma, compared with those of allergic asthma (P=0.01, P=0.01, respectively). Gadolinium 101-103 AA1 Homo sapiens 59-62 9677137-10 1998 RESULTS: There was a significant increase in the number of AA1+ and NE+ cells in bronchial mucosa of GD-induced asthma, compared with those of allergic asthma (P=0.01, P=0.01, respectively). Gadolinium 101-103 elastase, neutrophil expressed Homo sapiens 68-70 9762659-5 1998 From several relevant studies about CSF MBP in RR MS the following relations can be concluded: CSF MBP levels in active MS patients are frequently increased (45-100%), remain increased until 5 to 6 weeks after onset symptoms and are higher in polysymptomatic exacerbations and correlate with number of gadolinium-enhanced (Gd) lesions on MRI, severity of relapses, EDSS score and CSF intrathecal IgM synthesis. Gadolinium 302-312 myelin basic protein Homo sapiens 99-102 9530051-13 1998 Small HCCs measuring less than or equal to 1.5 cm were frequently isointense on both T1-weighted and T2-weighted images and may be detected on immediate gadolinium-enhanced images only as diffuse homogeneously enhancing lesions. Gadolinium 153-163 holocytochrome c synthase Homo sapiens 6-10 9415539-5 1997 Significantly fewer TLI-LDP patients had gadolinium enhancing plus new T2-weighted lesions (P=0.018) when compared to the sham group post-treatment. Gadolinium 41-51 carboxypeptidase Q Homo sapiens 24-27 9506551-3 1998 The activation of these pathways, one activated by IFNgamma and the other by the combination TNFalpha/IL-2/IL-6, is independent from myelin antigens and precedes by 2 weeks phases of disease activity (eg, clinical relapses and/or appearance of gadolinium-enhancing lesions on brain magnetic resonance imaging scans during 1 year of follow-up). Gadolinium 244-254 interleukin 6 Homo sapiens 107-111 9425162-5 1998 Amiloride and gadolinium, which block mechanosensation in vivo, inhibited RPK channels. Gadolinium 14-24 ripped pocket Drosophila melanogaster 74-77 9321915-7 1997 Addition of 500 microM gadolinium (Gd3+), an agent which has been shown to activate the CaR (E. M. Brown, G. Gamba, D. Riccardi, M. Lombardi, R. Butters, O. Kifor, A. Gadolinium 23-33 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 88-91 9364679-8 1997 In contrast, encapsulation of IL-4 into tgD-liposomes did not enhance the humoral immune response to gD but significantly influenced the development of antigen-specific IL-4 secreting cells. Gadolinium 41-43 interleukin 4 Homo sapiens 30-34 9364679-8 1997 In contrast, encapsulation of IL-4 into tgD-liposomes did not enhance the humoral immune response to gD but significantly influenced the development of antigen-specific IL-4 secreting cells. Gadolinium 41-43 interleukin 4 Homo sapiens 169-173 9385476-7 1997 IFN-beta reduces the number of new T2-weighted lesions, as well as the number and volume of gadolinium-enhanced lesions. Gadolinium 92-102 interferon beta 1 Homo sapiens 0-8 8994122-6 1996 In MS patients with MRI evidence of Gd-enhanced plaques CSF lactate was higher than in patients with MRI inactive plaques (p = 0.017). Gadolinium 36-38 colony stimulating factor 2 Homo sapiens 56-59 9307241-1 1997 This study analyzed the stability of the myelin basic protein (MBP)-specific T-cell receptor (TCR) repertoire during the course of multiple sclerosis (MS) in three patients who were monitored for three years by gadolinium-enhanced magnetic resonance imaging. Gadolinium 211-221 myelin basic protein Homo sapiens 63-66 8968027-3 1996 Gadolinium abolished loading-related increases in the release of PGI2 and NO and osteocyte G6PD activity. Gadolinium 0-10 glucose-6-phosphate dehydrogenase Rattus norvegicus 91-95 8968027-4 1996 Gadolinium also reduced the loading-related release of PGE2 assumed to originate from osteoblasts and the magnitude of loading-related increases in G6PD activity in these cells. Gadolinium 0-10 glucose-6-phosphate dehydrogenase Rattus norvegicus 148-152 9274854-0 1997 Glycodelins GdA and GdS modified by 3-hydroxyphthalic anhydride inhibit gp120-CD4 binding and HIV-1 infection in vitro. Gadolinium 20-23 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 72-77 9274854-0 1997 Glycodelins GdA and GdS modified by 3-hydroxyphthalic anhydride inhibit gp120-CD4 binding and HIV-1 infection in vitro. Gadolinium 20-23 CD4 molecule Homo sapiens 78-81 8960740-6 1996 The transient increase in the number of gadolinium-enhancing lesions that followed each infusion of cA2 together with the increase in cells and immunoglobulin in the CSF of each patient suggest that the treatment caused immune activation and an increase in disease activity. Gadolinium 40-50 carbonic anhydrase 2 Homo sapiens 100-103 8967390-7 1996 ECs pretreated with stretch-activated ion channel blocker gadolinium or with ryanodine to deplete intracellular stored Ca2+ strongly inhibited the strain-induced MCP-1 levels. Gadolinium 58-68 C-C motif chemokine ligand 2 Homo sapiens 162-167 8878438-2 1996 We have engineered 11 CaR mutants that have been described in the disorders familial benign hypercalcemia (FBH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalcaemia (ADH), and studied their function by characterizing intracellular calcium [Ca2+]i transients in response to varying concentrations of extracellular calcium [Ca2+]o or gadolinium [Gd3+]o. Gadolinium 362-372 calcium sensing receptor Homo sapiens 22-25 8896621-8 1996 This phenomenon is due to the combined T2-shortening effects of two paramagnetic substances, methemoglobin and gadolinium, which cause the signal reduction produced by the T2 effects to occur at lower concentrations of gadolinium. Gadolinium 219-229 hemoglobin subunit gamma 2 Homo sapiens 93-106 8781188-5 1996 The stretch-induced rise in BNP mRNA was blocked by gadolinium (80 microM), but not by the L-type channel blocker diltiazem (3.0 microM). Gadolinium 52-62 natriuretic peptide B Rattus norvegicus 28-31 8781188-7 1996 Gadolinium inhibits the stretch-stimulated rise in BNP mRNA levels in contracting and non-contracting atria, which is similar to its ability to block stretch-activated ir-ANP release, suggesting the involvement of Ca2+-permeable stretch-activated channels. Gadolinium 0-10 natriuretic peptide B Rattus norvegicus 51-54 8752105-10 1996 The plateau increase of [Ca2+]i caused by Ang II (100 nM) was reversibly inhibited by both cadmium (100 microM) and nifedipine (10 microM); in contrast, gadolinium (100 microM) had no effect on the plateau increase of [Ca2+]i. Gadolinium 153-163 angiotensinogen Rattus norvegicus 42-48 8725176-3 1996 We found that a panel of cations, including gadolinium, aluminum, calcium, and neomycin, inhibited prostaglandin E1 (PGE)-stimulated cAMP accumulation but paradoxically potentiated parathyroid hormone (PTH)-stimulated cAMP production. Gadolinium 44-54 parathyroid hormone Mus musculus 181-200 8649561-12 1996 Four patients with gadolinium enhancement on MRI had the most pronounced drop in gelatinase B and uPA. Gadolinium 19-29 plasminogen activator, urokinase Homo sapiens 98-101 9132165-1 1996 The effects of lanthanide ions (Ln(3+)), La(3+), Ce(3+), Gd(3+), and Tb(3+), on the binding ability of annexin V to phospholipid vesicle were studied, and compared with that of Ca(2+). Gadolinium 57-59 annexin A5 Homo sapiens 103-112 8619531-6 1996 MRI with gadolinium demonstrated enhancement of cranial nerve VIII bilaterally. Gadolinium 9-19 cytochrome c oxidase subunit 8A Homo sapiens 62-66 8602746-9 1996 Patients treated with interferon beta-1a also had significantly fewer exacerbations (p = 0.03) and a significantly lower number and volume of gadolinium-enhanced brain lesions on magnetic resonance images (p-values ranging between 0.02 and 0.05). Gadolinium 142-152 interferon beta 1 Homo sapiens 22-37 8602746-12 1996 Interferon beta-1a had a significant beneficial impact in relapsing multiple sclerosis patients by reducing the accumulation of permanent physical disability, exacerbation frequency, and disease activity measured by gadolinium-enhanced lesions on brain magnetic resonance images. Gadolinium 216-226 interferon beta 1 Homo sapiens 0-15 8642065-0 1996 Circulating L-selectin in multiple sclerosis patients with active, gadolinium-enhancing brain plaques. Gadolinium 67-77 selectin L Homo sapiens 12-22 9978216-0 1995 Spin-polarized photoemission studies of the exchange splitting of the Gd 5d electrons near the Curie temperature. Gadolinium 70-72 spindlin 1 Homo sapiens 0-4 8588642-2 1995 Advances can be attributed to several fields, but the most important contributions have arisen from the identification of the genes responsible for the dominant inheritance of neurofibromatosis types 1 (NF1) and 2 (NF2) and the development of magnetic resonance imaging with gadolinium enhancement for the early anatomic confirmation of the pathognomonic, bilateral vestibular schwannomas in NF2. Gadolinium 275-285 neurofibromin 1 Homo sapiens 203-206 8588642-2 1995 Advances can be attributed to several fields, but the most important contributions have arisen from the identification of the genes responsible for the dominant inheritance of neurofibromatosis types 1 (NF1) and 2 (NF2) and the development of magnetic resonance imaging with gadolinium enhancement for the early anatomic confirmation of the pathognomonic, bilateral vestibular schwannomas in NF2. Gadolinium 275-285 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 215-218 7544573-4 1995 Levels were highest in patients with gadolinium-enhancing lesions on magnetic resonance imaging (VCAM-1: 1,011 +/- 276 vs 626 +/- 87 ng/ml; L-selectin: 1,130 +/- 272 vs 793 +/- 207 ng/ml [mean +/- standard deviation]; p < 0.0001 vs patients without enhancing lesions). Gadolinium 37-47 vascular cell adhesion molecule 1 Homo sapiens 97-103 7869268-0 1994 Block of stretch-activated atrial natriuretic peptide secretion by gadolinium in isolated rat atrium. Gadolinium 67-77 natriuretic peptide A Rattus norvegicus 27-53 7674861-0 1995 ACTH-secreting islet cell tumor: appearances on dynamic gadolinium-enhanced MRI. Gadolinium 56-66 proopiomelanocortin Homo sapiens 0-4 7708190-1 1995 We examined 25 patients with recurrent pain after lumbar disk surgery with MRI to evaluate the usefulness of gadolinium (Gd)-enhanced fat-suppression (FS) imaging in patients with failed back surgery. Gadolinium 109-119 FAT atypical cadherin 1 Homo sapiens 134-137 7708190-1 1995 We examined 25 patients with recurrent pain after lumbar disk surgery with MRI to evaluate the usefulness of gadolinium (Gd)-enhanced fat-suppression (FS) imaging in patients with failed back surgery. Gadolinium 121-123 FAT atypical cadherin 1 Homo sapiens 134-137 7527442-6 1994 2) Additional of anti-IFN-gamma, but not anti-IL-2 or anti-IL-4, prevented the induction of NOS in the Gd-exposed KC and was associated with clone proliferation. Gadolinium 103-105 interferon gamma Mus musculus 22-31 7536719-3 1994 Spin-echo sequences after injection of gadolinium were studied by factor analysis of medical image sequences and were compared with a histologic quantification of tumor angiogenesis after immunocytochemical staining. Gadolinium 39-49 spindlin 1 Homo sapiens 0-4 7864085-6 1995 The mechanism of stretch-activated PLC activity involved influx of Ca2+ via gadolinium-sensitive ion channels, but not via nifedipine-sensitive ion channels. Gadolinium 76-86 LOC100009319 Oryctolagus cuniculus 35-38 7791547-5 1995 The parameters MTC and Rwm differed clearly between Gd-enhanced tumors and normal brain, whereas the relaxation time T1a was in many Gd-enhanced tumors in the same range as in normal brain. Gadolinium 133-135 podoplanin Homo sapiens 117-120 7791550-7 1995 The chelates containing long alkyl side chains, such as Gd(DTPA-HPA2), showed increased relaxivity values in the presence of human serum albumin (HSA), indicative of noncovalent interaction with the protein. Gadolinium 56-58 heparanase 2 (inactive) Homo sapiens 59-68 7791550-7 1995 The chelates containing long alkyl side chains, such as Gd(DTPA-HPA2), showed increased relaxivity values in the presence of human serum albumin (HSA), indicative of noncovalent interaction with the protein. Gadolinium 56-58 albumin Homo sapiens 131-144 8546801-6 1995 In addition, lymphocytes stimulated with gD or peptide 77 (residues 161-172) also produced IFN-gamma and IL-2. Gadolinium 41-43 interferon gamma Bos taurus 91-100 8546801-6 1995 In addition, lymphocytes stimulated with gD or peptide 77 (residues 161-172) also produced IFN-gamma and IL-2. Gadolinium 41-43 interleukin 2 Bos taurus 105-109 7869268-6 1994 The effect of gadolinium, a blocker of stretch-activated ion channels, on stretch-induced and basal ANP secretion was investigated by superfusing the atrial preparation with 5, 20 or 80 microM GdCl3. Gadolinium 14-24 natriuretic peptide A Rattus norvegicus 100-103 7869268-7 1994 Gadolinium decreased stretch-induced ANP secretion in a dose-dependent manner, but did not affect basal secretion. Gadolinium 0-10 natriuretic peptide A Rattus norvegicus 37-40 7869268-12 1994 Gadolinium, but not diltiazem, also inhibited stretch-stimulated ANP secretion in non-paced, quiescent atria. Gadolinium 0-10 natriuretic peptide A Rattus norvegicus 65-68 8139451-3 1993 NMRD relaxivity profiles of the three complexes indicate that the number of inner sphere water molecules for these chelates is < or = 1 and that the more hydrophobic chelate, Gd(DOTPMB), binds to human serum albumin (HSA). Gadolinium 178-180 albumin Rattus norvegicus 205-218 8024045-6 1994 The significantly greater decrease in PV in control compared with GD was associated with a higher muscle lactate content (Lac-; 36 vs. 17 mumol/g dry wt, respectively). Gadolinium 66-68 lactase Homo sapiens 122-125 8208120-0 1994 Stability assessment of gadolinium complexes by P-31 and H-1 relaxometry. Gadolinium 24-34 ATPase H+ transporting V1 subunit E1 Homo sapiens 48-52 10011343-0 1994 Magnetic structures of hcp bulk gadolinium. Gadolinium 32-42 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 23-26 8254338-8 1993 The intrinsic association constant of the metal, KM(H-1A), and the proton association constant, KH(H-1A) =, are found to be logKM(H-1A) = 7.00 +/- 0.03 and log KH(H-1A) = 7.08 +/- 0.06 for the Yb binding sites, and logKM (H-1A) = 6.16 +/- 0.08 and log KH(H-1A) = 6.63 +/- 0.10 for the Gd binding sites by a graphical analysis (A = BSA). Gadolinium 285-287 H1.1 linker histone, cluster member Homo sapiens 49-56 8254338-8 1993 The intrinsic association constant of the metal, KM(H-1A), and the proton association constant, KH(H-1A) =, are found to be logKM(H-1A) = 7.00 +/- 0.03 and log KH(H-1A) = 7.08 +/- 0.06 for the Yb binding sites, and logKM (H-1A) = 6.16 +/- 0.08 and log KH(H-1A) = 6.63 +/- 0.10 for the Gd binding sites by a graphical analysis (A = BSA). Gadolinium 285-287 H1.1 linker histone, cluster member Homo sapiens 96-103 8254338-8 1993 The intrinsic association constant of the metal, KM(H-1A), and the proton association constant, KH(H-1A) =, are found to be logKM(H-1A) = 7.00 +/- 0.03 and log KH(H-1A) = 7.08 +/- 0.06 for the Yb binding sites, and logKM (H-1A) = 6.16 +/- 0.08 and log KH(H-1A) = 6.63 +/- 0.10 for the Gd binding sites by a graphical analysis (A = BSA). Gadolinium 285-287 H1.1 linker histone, cluster member Homo sapiens 160-167 8254338-8 1993 The intrinsic association constant of the metal, KM(H-1A), and the proton association constant, KH(H-1A) =, are found to be logKM(H-1A) = 7.00 +/- 0.03 and log KH(H-1A) = 7.08 +/- 0.06 for the Yb binding sites, and logKM (H-1A) = 6.16 +/- 0.08 and log KH(H-1A) = 6.63 +/- 0.10 for the Gd binding sites by a graphical analysis (A = BSA). Gadolinium 285-287 H1.1 linker histone, cluster member Homo sapiens 160-167 8491259-1 1993 The rare earth lanthanide gadolinium (Gd3+), in concentrations ranging from 1 to 100 microM, reduced the elevation of intracellular Ca2+ concentration [Ca2+]i, monitored by means of the fluorescent probe fura-2. Gadolinium 26-36 GRDX Homo sapiens 38-41 1319710-7 1992 Lymphoproliferative responses were abrogated in gD-immunized mice treated with anti-Thy1 or anti-L3T4, anti-Lyt2 treatment having little effect. Gadolinium 48-50 thymus cell antigen 1, theta Mus musculus 84-88 1438756-5 1992 The accuracy of staging the intramural extent (pT1-pT3a) of bladder tumors was thus improved with gadolinium-enhanced dynamic MR imaging. Gadolinium 98-108 zinc finger protein 77 Homo sapiens 47-50 1527624-4 1992 Gadolinium-enhanced magnetic resonance imaging, showed an intramedullary lesion at the C-2 level. Gadolinium 0-10 complement C2 Homo sapiens 87-90 1319710-7 1992 Lymphoproliferative responses were abrogated in gD-immunized mice treated with anti-Thy1 or anti-L3T4, anti-Lyt2 treatment having little effect. Gadolinium 48-50 CD8 antigen, alpha chain Mus musculus 108-112 10045257-0 1992 Temperature-dependent conduction-band exchange splitting in ferromagnetic hcp gadolinium: Theoretical predictions and photoemission experiments. Gadolinium 78-88 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 74-77 1798393-4 1991 The clearance rate of Gd(DTPA) from blood allows repeated measurements of CBF to be made using this technique approximately every 30 min. Gadolinium 22-24 CCAAT/enhancer binding protein zeta Rattus norvegicus 74-77 10044701-0 1991 Spin-lattice relaxation time of ferromagnetic gadolinium determined with time-resolved spin-polarized photoemission. Gadolinium 46-56 spindlin 1 Homo sapiens 0-4 10044701-0 1991 Spin-lattice relaxation time of ferromagnetic gadolinium determined with time-resolved spin-polarized photoemission. Gadolinium 46-56 spindlin 1 Homo sapiens 87-91 1789288-1 1991 We report on a family in which individuals at risk for NF 2 were investigated with the use of gadolinium-enhanced MRI. Gadolinium 94-104 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 55-59 2358888-12 1990 The effect of NPY to reduce calcium current was blocked in the presence of gadolinium (1 microM), a putative N channel antagonist. Gadolinium 75-85 neuropeptide Y Rattus norvegicus 14-17 2281944-4 1990 Only one isolated incidence of Gd- was encountered in the Naga, while the Hmar lacked Gd-. Gadolinium 31-33 alpha-N-acetylgalactosaminidase Homo sapiens 58-62 1686201-2 1991 The actions of the trivalent cation, gadolinium (Gd3+), were studied on frog isolated neuromuscular preparations by conventional electrophysiological techniques. Gadolinium 37-47 GRDX Homo sapiens 49-52 2108484-3 1990 Gadolinium enhanced MRI is extremely useful in diagnosing and defining the extent of intracranial and intraspinal lesions, does not involve radiation exposure and should therefore be recommended generously in follow-up patients with known NF. Gadolinium 0-10 neurofibromin 1 Homo sapiens 239-241 2118207-3 1990 Release of Gd3+ from the complex is responsible for the toxicity associated with gadolinium complexes; this release appears to be a consequence of Zn2+, Cu2+, and Ca2+ transmetallation in vivo. Gadolinium 81-91 GRDX Homo sapiens 11-14 34838324-2 2022 Herein, the peroxidase-like activity of single-atom copper anchored on bovine hemoglobin-template gadolinium nanoparticles (Cu,Gd@BHbFITC NPs) were successfully synthesized and two sensitive turn-on fluorescence strategies for tyrosinase (TYR) activity sensing were proposed for the first time. Gadolinium 98-108 tyrosinase Bos taurus 227-237 33761112-2 2021 Acute exposure to nerve agents such as soman (GD) causes serious brain damage, leading to death due to intense seizures induced by acetylcholinesterase inhibition and neuronal injury resulting from increased excitatory amino-acid levels and neuroinflammation. Gadolinium 46-48 acetylcholinesterase Rattus norvegicus 131-151 33804005-6 2021 A literature review of the described cases of NSF occurrence after exposure to gadolinium-containing contrast agents was performed. Gadolinium 79-89 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 46-49 33034320-4 2020 In this study, we developed a matrix metalloproteinase-2 (MMP-2) activatable nanoprobe (PEG-PepMMP2-MNP-Gd), which was composed of water-insoluble gadolinium-chelated melanin (MNP-Gd), MMP-2 cleaved peptide and enzymatic detachable polyethylene glycol (PEG). Gadolinium 147-157 matrix metallopeptidase 2 Mus musculus 30-56 33034320-4 2020 In this study, we developed a matrix metalloproteinase-2 (MMP-2) activatable nanoprobe (PEG-PepMMP2-MNP-Gd), which was composed of water-insoluble gadolinium-chelated melanin (MNP-Gd), MMP-2 cleaved peptide and enzymatic detachable polyethylene glycol (PEG). Gadolinium 147-157 matrix metallopeptidase 2 Mus musculus 58-63 24852289-2 2014 This study evaluates the additional benefits of intrathecal gadolinium MR myelography in the detection of CSF leak. Gadolinium 60-70 colony stimulating factor 2 Homo sapiens 106-109 24852289-8 2014 In 3/24 patients (13%), a CSF leak was demonstrated on both CT myelography and intrathecal gadolinium MR myelography, and in 9/24 patients (38%), a CSF leak was seen on intrathecal gadolinium MR myelography (P = .011). Gadolinium 91-101 colony stimulating factor 2 Homo sapiens 26-29 24852289-12 2014 CONCLUSIONS: Present data demonstrate a higher rate of leak detection with intrathecal gadolinium MR myelography when investigating CSF leaks in our cohort of patients with spontaneous intracranial hypotension. Gadolinium 87-97 colony stimulating factor 2 Homo sapiens 132-135 34973973-2 2022 Polymorphisms of hypoxia inducible factor-1-alpha (HIF1alpha) have been associated the fibrotic burden by cardiac magnetic resonance (CMR) late gadolinium enhancement imaging. Gadolinium 144-154 hypoxia inducible factor 1 subunit alpha Homo sapiens 17-49 34973973-2 2022 Polymorphisms of hypoxia inducible factor-1-alpha (HIF1alpha) have been associated the fibrotic burden by cardiac magnetic resonance (CMR) late gadolinium enhancement imaging. Gadolinium 144-154 hypoxia inducible factor 1 subunit alpha Homo sapiens 51-60 34756894-9 2022 sST2 and GDF-15 were significantly correlated with late gadolinium enhancement in CMR and with adverse heart failure outcomes. Gadolinium 56-66 growth differentiation factor 15 Homo sapiens 9-15 34775124-3 2022 Here, we designed a theranostic nanoplatform, named FCS/GCS, by incorporating amphiphilic polymer skeletal (P-SS-D), cinnamaldehyde prodrug (CA-OH) and iron ions (Fe3+)/gadolinium ions (Gd3+) via chelation reactions between Fe3+/Gd3+ and polyphenols. Gadolinium 169-179 GRDX Homo sapiens 186-189 34775124-3 2022 Here, we designed a theranostic nanoplatform, named FCS/GCS, by incorporating amphiphilic polymer skeletal (P-SS-D), cinnamaldehyde prodrug (CA-OH) and iron ions (Fe3+)/gadolinium ions (Gd3+) via chelation reactions between Fe3+/Gd3+ and polyphenols. Gadolinium 169-179 GRDX Homo sapiens 229-232 34838324-2 2022 Herein, the peroxidase-like activity of single-atom copper anchored on bovine hemoglobin-template gadolinium nanoparticles (Cu,Gd@BHbFITC NPs) were successfully synthesized and two sensitive turn-on fluorescence strategies for tyrosinase (TYR) activity sensing were proposed for the first time. Gadolinium 98-108 tyrosinase Bos taurus 239-242 34734510-0 2021 Skin Test Results and Cross-Reactivity Patterns in IgE- and T-Cell-Mediated Allergy to Gadolinium-Based Contrast Agents. Gadolinium 87-97 immunoglobulin heavy constant epsilon Homo sapiens 51-54 34278598-2 2021 This study aimed to explore the potential of gadolinium (Gd)-labelled cyclic peptides (pPB) targeting PDGF receptor-beta (PDGFR-beta) as a magnetic resonance imaging (MRI) radiotracer to identify the progression of liver fibrosis by imaging hepatic PDGFR-beta expression. Gadolinium 45-55 platelet derived growth factor receptor, alpha polypeptide Mus musculus 122-132 34278598-2 2021 This study aimed to explore the potential of gadolinium (Gd)-labelled cyclic peptides (pPB) targeting PDGF receptor-beta (PDGFR-beta) as a magnetic resonance imaging (MRI) radiotracer to identify the progression of liver fibrosis by imaging hepatic PDGFR-beta expression. Gadolinium 45-55 platelet derived growth factor receptor, alpha polypeptide Mus musculus 249-259 34278598-2 2021 This study aimed to explore the potential of gadolinium (Gd)-labelled cyclic peptides (pPB) targeting PDGF receptor-beta (PDGFR-beta) as a magnetic resonance imaging (MRI) radiotracer to identify the progression of liver fibrosis by imaging hepatic PDGFR-beta expression. Gadolinium 57-59 platelet derived growth factor receptor, alpha polypeptide Mus musculus 122-132 34278598-2 2021 This study aimed to explore the potential of gadolinium (Gd)-labelled cyclic peptides (pPB) targeting PDGF receptor-beta (PDGFR-beta) as a magnetic resonance imaging (MRI) radiotracer to identify the progression of liver fibrosis by imaging hepatic PDGFR-beta expression. Gadolinium 57-59 platelet derived growth factor receptor, alpha polypeptide Mus musculus 249-259 34570589-0 2021 Editorial Comment: Toward Meeting ACR-ASNR Guidelines for Reducing Gadolinium-Based Contrast Agent Dose in Brain MRI Examinations. Gadolinium 67-77 acrosin Homo sapiens 34-37 34416258-3 2021 A recent study showed that NFKB activation in EBVNPC drives somatostatin receptor 2 (SSTR2) expression that is detectable by immunohistochemistry and by imaging with 68-Gadolinium-DOTA-peptide radioconjugate. Gadolinium 169-179 somatostatin receptor 2 Homo sapiens 60-83 34416258-3 2021 A recent study showed that NFKB activation in EBVNPC drives somatostatin receptor 2 (SSTR2) expression that is detectable by immunohistochemistry and by imaging with 68-Gadolinium-DOTA-peptide radioconjugate. Gadolinium 169-179 somatostatin receptor 2 Homo sapiens 85-90 34661390-0 2021 Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin. Gadolinium 76-86 elastin Mus musculus 126-138 34284047-0 2021 Gadolinium-labeled affibody-XTEN recombinant vector for detection of HER2+ lesions of ovarian cancer lung metastasis using quantitative MRI. Gadolinium 0-10 erb-b2 receptor tyrosine kinase 2 Mus musculus 69-73 34690107-9 2022 CONCLUSION: This study demonstrates that the sensitivity of 3D-FLAIR sequences to low concentration gadolinium in the perilymphatic space is improved by elongation of the TR, with SIR and CNR increased by +34.4% and +41.3% respectively. Gadolinium 100-110 coagulation factor II thrombin receptor Homo sapiens 171-173 34647709-2 2021 Our study aimed to assess whether the range of MET and Tl accumulation could be predicted from the contrast-enhanced lesions in Gadolinium (Gd)- 1 weighted MR image (Gd-MRI) in glioblastoma multiforme (GBM) patients. Gadolinium 128-138 SAFB like transcription modulator Homo sapiens 47-50 34656480-2 2022 BACKGROUND: Late gadolinium enhancement (LGE) CMR and FDG-PET are both established imaging techniques for the detection of CS. Gadolinium 17-27 citrate synthase Homo sapiens 123-125 34683886-3 2021 Herein, a multiple targeted engineered exosomes nanoplatform was constructed through rare earth element Gd and Dy-doped and TAT peptide-modified carbon dots (CDs:Gd,Dy-TAT) encapsulated into RGD peptide engineered exosomes (Exo-RGD), which were used to enhance the effect of cancer imaging diagnosis and photothermal therapy. Gadolinium 162-164 5'-3' exoribonuclease 1 Mus musculus 224-227 34683886-4 2021 In vitro and in vivo experiments showed that the resulting CDs:Gd,Dy-TAT@Exo-RGD could effectively accumulate at cancer site with an increased concentration owing to the targeting peptides modification and exosomes encapsulation. Gadolinium 63-65 5'-3' exoribonuclease 1 Mus musculus 73-76 34683886-8 2021 In addition, the CDs:Gd,Dy-TAT@Exo-RGD exhibited higher MRI/CT imaging contrast enhancement of tumor sites than that of CDs:Gd,Dy. Gadolinium 21-23 calcitonin/calcitonin-related polypeptide, alpha Mus musculus 60-62 34319623-3 2021 Here, a heavy-fermion behavior of ferromagnetic gadolinium lattice in Gd3 SnC antiperovskite is reported, contradicting the common belief that ferromagnetic gadolinium cannot be a heavy-fermion system due to the deep energy level of localized 4f-electrons. Gadolinium 48-58 GRDX Homo sapiens 70-73 34412037-2 2021 For high fields a classical spin model of the gadolinium ions predicts a spin configuration that is periodic at the level of the smallest repeating unit cell. Gadolinium 46-56 spindlin 1 Homo sapiens 28-32 34412037-2 2021 For high fields a classical spin model of the gadolinium ions predicts a spin configuration that is periodic at the level of the smallest repeating unit cell. Gadolinium 46-56 spindlin 1 Homo sapiens 73-77 34382270-12 2021 Furthermore, due to the specific binding between AS1411 and nucleolin up-expressed in cancer cells, the AS-nFAp:Gd/Tb possessed excellent AS1411-targeted fluorescence and MRI imaging properties. Gadolinium 112-114 nucleolin Homo sapiens 60-69 34102413-9 2021 The results showed the feasibility of measuring a DEF of 1.15 +- 0.05 in 20 mg/ml of Gd concentration consistent with the Monte Carlo DEF of 1.112 +- 0.005 for the same concentration. Gadolinium 85-87 UTP25 small subunit processome component Homo sapiens 50-53 34322829-4 2021 An experienced neuroradiologist interpreted early responses on fluid-attenuated inversion recovery (FLAIR) and gadolinium-enhanced T1-weighted images (GdT1WI). Gadolinium 111-121 transmembrane protein 165 Homo sapiens 151-157 34237936-1 2021 A novel bifunctional saponite clay incorporating gadolinium (Gd3+) and europium (Eu3+) in the inorganic framework was prepared by one-pot hydrothermal synthesis. Gadolinium 49-59 GRDX Homo sapiens 61-64 34392718-5 2022 RESULTS: RRMS with relapse had 4.4 times higher median cNFL concentration (1134 (interquartile range (IQR) 499-2744) ng/L) than those without relapse (264 (125-537) ng/L, p < 0.001) and patients with gadolinium-enhancing lesions had 3.3 times higher median NFL (1414 (606.8-3210) ng/L) than those without (426 (IQR 221-851) ng/L, p < 0.001). Gadolinium 200-210 neurofilament light chain Homo sapiens 257-260 34126146-0 2021 The inhibition of gadolinium ion (Gd3+) on the mitochondrial F1FO-ATPase is linked to the modulation of the mitochondrial permeability transition pore. Gadolinium 18-28 GRDX Homo sapiens 34-37 34126146-2 2021 The effects of the gadolinium cation (Gd3+), widely used for diagnosis and therapy, and reported as PTP blocker, were evaluated on the F1FO-ATPase activated by Mg2+ or Ca2+ and on the PTP. Gadolinium 19-29 GRDX Homo sapiens 38-41 34429516-10 2021 Those with elevated cTnI were more likely to have late gadolinium enhancement on baseline CMR. Gadolinium 55-65 troponin I3, cardiac type Homo sapiens 20-24 34113554-5 2021 Here an XPCT qualitative study on NPs distribution in a mouse brain model of melanoma metastases injected with gadolinium-based NPs for theranostics is presented. Gadolinium 111-121 solute carrier family 16 (monocarboxylic acid transporters), member 2 Mus musculus 8-12 34361202-2 2021 In this study, Gd3+/ZnO (ZnOGd) were conjugated with Qdots composed of a gadolinium-copper-indium-sulphur core covered with a ZnS shell (GCIS/ZnS Qdots). Gadolinium 73-83 GRDX Homo sapiens 15-18 34986707-3 2022 Release kinetics were measured in vitro and in vivo with MRI, using gadolinium-labeled albumin (Galbumin), which demonstrated prolonged release over multiple weeks. Gadolinium 68-78 albumin Rattus norvegicus 87-94 35432684-2 2022 Incidentally, there was a markedly PSMA avid (SUVmax 7.0) lobulated periventricular mass in the region of the left basal ganglia which was T2 hyperintense and T1 hypointense with perilesional oedema and vivid Gadolinium enhancement on MRI. Gadolinium 209-219 folate hydrolase 1 Homo sapiens 35-39 35600977-4 2023 Incorporation of gadolinium in the hydrophilic chain segment of the OEGMA-based carrier resulted in a high r 1 value for Gd-DOTA-TPBP, revealing a great MR imaging resolution. Gadolinium 17-27 trophoblast specific protein alpha Mus musculus 129-133 35325694-10 2022 The obtained data reveal that it possesses an unstructured conformation and binds to HVEM in the same location as gD and BTLA. Gadolinium 114-116 TNF receptor superfamily member 14 Homo sapiens 85-89 35615385-9 2022 In 70 patients with ON-associated pain, gadolinium enhancement of orbital optic nerve was most common in MOG-ON patients (82.4 vs. 55.0 vs. 33.3%, P = 0.018), and enhancement of optic chiasma was most common in AQP4-ON patients (40.0 vs. 5.9 vs. 6.7%, P = 0.015). Gadolinium 40-50 myelin oligodendrocyte glycoprotein Homo sapiens 105-108 35615385-9 2022 In 70 patients with ON-associated pain, gadolinium enhancement of orbital optic nerve was most common in MOG-ON patients (82.4 vs. 55.0 vs. 33.3%, P = 0.018), and enhancement of optic chiasma was most common in AQP4-ON patients (40.0 vs. 5.9 vs. 6.7%, P = 0.015). Gadolinium 40-50 aquaporin 4 Homo sapiens 211-215 35486294-4 2022 PROCEDURES: A time-stable material mimicking the MR properties of methemoglobin in IPH was created by doping agarose hydrogel with gadolinium and sodium alginate. Gadolinium 131-141 hemoglobin subunit gamma 2 Homo sapiens 66-79 35227379-2 2022 Inspired by biomineralization approaches for integrating nanoscale materials, herein, a gadolinium (Gd)-integrated polypyrrole (PPy) electrocatalyst (namely, BSA@PPy-Gd) was successfully prepared by choosing bovine serum albumin (BSA) as a stabilizer for biomimetic mineralization and polymerization in a "one-step" manner. Gadolinium 88-98 albumin Rattus norvegicus 215-228 35393504-0 2022 Gadolinium-based contrast agent accelerates the migration of astrocyte via integrin alphavbeta3 signaling pathway. Gadolinium 0-10 integrin subunit alpha V Homo sapiens 75-95 35146565-1 2022 OBJECTIVE: We describe an unusual case of corticosteroid-responsive autoimmune meningoencephalomyelitis with linear perivascular gadolinium enhancement but in the absence of anti- glial fibrillary acidic protein (GFAP) antibodies (ABs) in the cerebral spinal fluid (CSF). Gadolinium 129-139 glial fibrillary acidic protein Homo sapiens 213-217 9948004-0 1989 Spin dynamics of Gd at high temperatures. Gadolinium 17-19 spindlin 1 Homo sapiens 0-4 35328725-0 2022 Using ELP Repeats as a Scaffold for De Novo Construction of Gadolinium-Binding Domains within Multifunctional Recombinant Proteins for Targeted Delivery of Gadolinium to Tumour Cells. Gadolinium 60-70 nuclear receptor subfamily 5 group A member 1 Homo sapiens 6-9 35328725-0 2022 Using ELP Repeats as a Scaffold for De Novo Construction of Gadolinium-Binding Domains within Multifunctional Recombinant Proteins for Targeted Delivery of Gadolinium to Tumour Cells. Gadolinium 156-166 nuclear receptor subfamily 5 group A member 1 Homo sapiens 6-9 35335320-6 2022 Results of ecotoxicological tests suggest that harzianic acid can decrease gadolinium biotoxicity, presumably because of complex formation with Gd3+. Gadolinium 75-85 GRDX Homo sapiens 144-147 35302826-1 2022 We investigate the magnetic excitations of elemental gadolinium (Gd) using inelastic neutron scattering, showing that Gd is a Dirac magnon material with nodal lines at K and nodal planes at half integer l. We find an anisotropic intensity winding around the K-point Dirac magnon cone, which is interpreted to indicate Berry phase physics. Gadolinium 53-63 nodal growth differentiation factor Homo sapiens 153-158 35106524-6 2022 The most researched materials for magnetocaloric applications are those containing Gd as their magnetic centre, as the combination of structure and the weakly interacting 4f orbitals of Gd3+ in these materials enables the fabrication of promising magnetocalorics that contain a high density of cations and thus exhibit a high entropy change as a function of their weight and volume at ultra-low cryogenic temperatures. Gadolinium 83-85 GRDX Homo sapiens 186-189 35104892-0 2022 Imaging of myofascial taut bands using gadolinium-enhanced magnetic resonance imaging. Gadolinium 39-49 solute carrier family 6 member 6 Homo sapiens 22-26 35128083-2 2022 Exposure to GBCAs can result in gadolinium deposition within human tissues and has become a clinical concern because of the potential toxic effects of free gadolinium (Gd3+). Gadolinium 156-166 GRDX Homo sapiens 168-171 34987653-3 2022 Methods: Herein, we investigated the MR property of a gamma-glutamyl transpeptidase (GGT)-instructed, intracellular formed gadolinium nanoparticle (DOTA-Gd-CBT-NP) at low and high magnetic fields. Gadolinium 123-133 inactive glutathione hydrolase 2 Homo sapiens 54-83 34987653-3 2022 Methods: Herein, we investigated the MR property of a gamma-glutamyl transpeptidase (GGT)-instructed, intracellular formed gadolinium nanoparticle (DOTA-Gd-CBT-NP) at low and high magnetic fields. Gadolinium 123-133 inactive glutathione hydrolase 2 Homo sapiens 85-88 35214969-6 2022 The Pdots were post-functionalized by 1,4,7,10 tetraazacyclododecane-1,4,7,10-tetraacetic acid for chelating gadolinium nanoparticles (Gd3+) that provide magnetic properties to the Pdots. Gadolinium 109-119 GRDX Homo sapiens 135-138 35200706-4 2022 Scar was confirmed by the distribution of late gadolinium enhancement with cardiac magnetic resonance imaging (cMRI). Gadolinium 47-57 ribosomal protein S4 X-linked Homo sapiens 0-4 35086421-5 2022 More specifically, late gadolinium enhancement (LGE), a CMR tool for scar detection, has been found to be significantly associated with arrhythmic events in CS patients. Gadolinium 24-34 citrate synthase Homo sapiens 157-159 3210955-3 1988 Although the thermodynamic constants for Gd3+ binding to DTPA-monopropylamide and DTPA-monopropylester relative to Gd(DTPA)2- decrease by log K = 2.6 and 3.4, respectively, the blood pH conditional constants differ from Gd(DTPA)2- only by log K = 1.2 and 1.9, respectively. Gadolinium 115-117 GRDX Homo sapiens 41-44 3170830-0 1988 Gadolinium DTPA enhanced MR imaging of ACTH-secreting microadenomas of the pituitary gland. Gadolinium 0-10 proopiomelanocortin Homo sapiens 39-43 3384818-2 1988 Prothrombin possesses two high affinity and four low affinity gamma-carboxyglutamic acid (Gla)-dependent gadolinium binding sites. Gadolinium 105-115 coagulation factor II, thrombin Homo sapiens 0-11 3255735-2 1988 Gd(DTPA)2- and Gd(DOTA)- had similar distributions with greater than 89% renally excreted in 1 h. Gadolinium 0-2 inversion, Chr X, Harwell 1 Mus musculus 90-96 3422166-16 1988 Preincubation of LACI(HG2) with saturating concentrations of BXa(-GD) markedly retarded the subsequent inhibition of BXa. Gadolinium 65-68 tissue factor pathway inhibitor Homo sapiens 17-21 3422166-16 1988 Preincubation of LACI(HG2) with saturating concentrations of BXa(-GD) markedly retarded the subsequent inhibition of BXa. Gadolinium 65-68 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 22-25 3008831-0 1986 Electron spin resonance and magnetic relaxation studies of gadolinium(III) complexes with human transferrin. Gadolinium 59-69 transferrin Homo sapiens 96-107 9940485-0 1986 Spin-polarized Auger electron spectroscopy on Gd. Gadolinium 46-48 spindlin 1 Homo sapiens 0-4 2835077-0 1988 Spectroscopic and thermodynamic studies on the binding of gadolinium(III) to human serum transferrin. Gadolinium 58-68 transferrin Homo sapiens 89-100 2849025-3 1987 Employing a direct binding assay, consisting of purified HSV glycoproteins immobilized on nitrocellulose and iodinated C3b as a probe, we found that C3b binds directly to gC-1, as well as to gC-2, but not to gB or gD from either serotype. Gadolinium 214-216 complement C3 Homo sapiens 149-152 3746817-7 1986 The in vitro reactivation potency of the alpha-keto thiohydroximates approaches and even surpasses that of 2-PAM and toxogonin for GD-inhibited AChE. Gadolinium 131-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 151-153 serine/threonine-protein kinase ATR Cavia porcellus 117-120 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 151-153 peptidyl-glycine alpha-amidating monooxygenase Cavia porcellus 123-126 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 188-190 serine/threonine-protein kinase ATR Cavia porcellus 117-120 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 188-190 peptidyl-glycine alpha-amidating monooxygenase Cavia porcellus 123-126 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 188-190 serine/threonine-protein kinase ATR Cavia porcellus 208-211 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 188-190 serine/threonine-protein kinase ATR Cavia porcellus 117-120 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 188-190 peptidyl-glycine alpha-amidating monooxygenase Cavia porcellus 123-126 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 188-190 serine/threonine-protein kinase ATR Cavia porcellus 208-211 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 188-190 serine/threonine-protein kinase ATR Cavia porcellus 117-120 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 188-190 peptidyl-glycine alpha-amidating monooxygenase Cavia porcellus 123-126 4092891-4 1985 Exploration of the response surface indicates that the optimal treatment combinations (greater than 94% survival) of ATR/2-PAM change as a function of GD exposure in the following manner: GD 30 micrograms/kg-ATR/2-PAM, 217 mg/kg/0 mg/kg; GD 42.4 micrograms/kg-179/29 mg/kg; mg/kg; GD 60 micrograms/kg-148/83 mg/kg; GD 84.6 micrograms/kg-168/150 mg/kg. Gadolinium 188-190 serine/threonine-protein kinase ATR Cavia porcellus 208-211 4057105-0 1985 Gadolinium ions inhibit exocytotic vasopressin release from the rat neurohypophysis. Gadolinium 0-10 arginine vasopressin Rattus norvegicus 35-46 4066240-6 1985 An in vivo experiment using anticarcinoembryonic antigen (CEA) monoclonal antibody-DTPA-Gd in hamsters implanted with human colon carcinoma resulted in a tumor concentration of Gd of less than 10(-4) mM. Gadolinium 88-90 CEA cell adhesion molecule 3 Homo sapiens 58-61 15542-1 1977 The binding of gadolinium [Gd(III)] to a homogeneous rabbit anti-(type-III pneumococcal polysaccharide) IgG (immunoglobulin G) and its Fab (N-terminal half of heavy and light chain) and Fc (C-terminal half of heavy-chain dimer) fragments was demonstrated by measurements of solvent-water proton relaxation rates in the appropriate Gd(III) solutions. Gadolinium 15-25 FA complementation group B Homo sapiens 135-138 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. Gadolinium 186-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. Gadolinium 186-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 3974886-7 1985 Gadolinium ions (Gd3+) added to the homogenization medium of unstimulated hearts reduced the soluble fraction of dopamine beta-hydroxylase up to 63%, with the maximum effect at 200 microM. Gadolinium 0-10 dopamine beta-hydroxylase Oryctolagus cuniculus 113-138 7107632-9 1982 The dimerization of bovine prothrombin is also supported by strontium and gadolinium to an extent comparable to that of calcium and to a lesser extent by barium or manganese. Gadolinium 74-84 coagulation factor II, thrombin Bos taurus 27-38 6267177-8 1981 Pulse-chase experiments and treatment of infected cells with neuraminidase suggested that glycoproteins gB, gC and gD contain sialic acid and that synthesis of gB and gD occurs by at least 15 and 10 discrete steps respectively. Gadolinium 115-117 neuraminidase 1 Homo sapiens 61-74 7352983-8 1980 Applications of these calculations are described to compare the tetragonal and triclinic forms of native lysozyme, to propose several assignments of 1H NMR signals in the spectrum of lysozyme, and to analyze some of the conformational changes which occur on the binding of Gd(III) and GlcNAc sugars to lysozyme. Gadolinium 273-275 lysozyme Homo sapiens 105-113 7352983-8 1980 Applications of these calculations are described to compare the tetragonal and triclinic forms of native lysozyme, to propose several assignments of 1H NMR signals in the spectrum of lysozyme, and to analyze some of the conformational changes which occur on the binding of Gd(III) and GlcNAc sugars to lysozyme. Gadolinium 273-275 lysozyme Homo sapiens 183-191 7352983-8 1980 Applications of these calculations are described to compare the tetragonal and triclinic forms of native lysozyme, to propose several assignments of 1H NMR signals in the spectrum of lysozyme, and to analyze some of the conformational changes which occur on the binding of Gd(III) and GlcNAc sugars to lysozyme. Gadolinium 273-275 lysozyme Homo sapiens 183-191 1237314-4 1975 Binding constants of 3.3 x 10(3) and 4.1 x 10(3) M-1 for the association of Gd(III) with alpha-trypsin and beta-trypsin, respectively, in the presence of p-toluamidine at pH 6.0 have been obtained by equilibrium dialysis. Gadolinium 76-78 serine protease 1 Bos taurus 107-119 945070-0 1976 Phospholipase A2 complexes with gadolinium (III) and interaction of the enzyme-metal ion complex with monomeric and micellar alkylphosphorylcholines. Gadolinium 32-42 phospholipase A2 group IB Homo sapiens 0-16 164224-9 1975 Addition of the paramagnetic gadolinium ion to spin-labelled enzyme reduces the intensity of both the spin label signals (by 72% for the mobile and by 11% for the immobile component). Gadolinium 29-39 spindlin 1 Homo sapiens 47-51 34047663-8 2021 The maximum DEF at 30, 60, and 100 keV photon energies were respectively related to Silver (Ag), Gadolinium (Gd), and Bismuth (Bi) NPs. Gadolinium 97-107 UTP25 small subunit processome component Homo sapiens 12-15 34047663-8 2021 The maximum DEF at 30, 60, and 100 keV photon energies were respectively related to Silver (Ag), Gadolinium (Gd), and Bismuth (Bi) NPs. Gadolinium 109-111 UTP25 small subunit processome component Homo sapiens 12-15 164224-9 1975 Addition of the paramagnetic gadolinium ion to spin-labelled enzyme reduces the intensity of both the spin label signals (by 72% for the mobile and by 11% for the immobile component). Gadolinium 29-39 spindlin 1 Homo sapiens 102-106 164224-11 1975 Measurements of the effect of gadolinium-protein binding on the relaxation rate of solvent water protons enable the enzyme-bound spin label-metal ion distances to be tentatively estimated as 15 angstrom. Gadolinium 30-40 spindlin 1 Homo sapiens 129-133 33815603-0 2021 Gadolinium-based contrast agents in neurofibromatosis type 1 (Review). Gadolinium 0-10 neurofibromin 1 Homo sapiens 36-60 34055936-10 2021 Compared with patients without cardiac injury, patients with cardiac injury exhibited a significantly higher positive proportion in late gadolinium enhancement sequences [7/13 (53.8%) vs. 1/14 (7.1%), p = 0.013], accompanied by the elevation of circulating ST2 level [median (interquartile range) = 16.6 (12.1, 22.5) vs. 12.5 (9.5, 16.7); p = 0.044]. Gadolinium 137-147 ST2 Homo sapiens 257-260 34055936-12 2021 Among patients with cardiac injury, patients with positive late gadolinium enhancement presented higher cardiac biomarker (high-sensitivity troponin I) and inflammatory factor (high-sensitivity C-reactive protein) on admission than the late gadolinium enhancement-negative subgroup. Gadolinium 64-74 C-reactive protein Homo sapiens 194-212 33581614-7 2021 Out of all these biomarkers, only MMP-1 was able to differentiate between early MS and CIS, and was found to correlate with lesion volume and gadolinium enhancing lesions on MRI. Gadolinium 142-152 matrix metallopeptidase 1 Homo sapiens 34-39 32740939-0 2021 Interference of gadolinium dechelated from MR contrast agents by calcium signaling in neuronal cells of GnRH. Gadolinium 16-26 gonadotropin releasing hormone 1 Mus musculus 104-108 34007253-10 2021 In addition, a strong visual colocalization of albumin-positive areas in the fluorescence albumin staining with gadolinium distribution in LA-ICP-MS was shown. Gadolinium 112-122 albumin Mus musculus 47-54 34007253-10 2021 In addition, a strong visual colocalization of albumin-positive areas in the fluorescence albumin staining with gadolinium distribution in LA-ICP-MS was shown. Gadolinium 112-122 albumin Mus musculus 90-97 33225427-2 2021 The presence of CS is typically evaluated using 18F-fluorodeoxyglucose (18F-FDG) uptake on cardiac positron emission tomography (PET) or late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR). Gadolinium 142-152 citrate synthase Homo sapiens 16-18 33916181-2 2021 The contrast agents showed MR relaxivities typical of gadolinium complexes with a single water molecule coordinated to a Gd3+ center (i.e., ~4.54 mM-1s-1) for both CA1 and CA2 at 60 MHz. Gadolinium 54-64 GRDX Homo sapiens 121-124 33916181-2 2021 The contrast agents showed MR relaxivities typical of gadolinium complexes with a single water molecule coordinated to a Gd3+ center (i.e., ~4.54 mM-1s-1) for both CA1 and CA2 at 60 MHz. Gadolinium 54-64 carbonic anhydrase 1 Homo sapiens 164-167 33916181-2 2021 The contrast agents showed MR relaxivities typical of gadolinium complexes with a single water molecule coordinated to a Gd3+ center (i.e., ~4.54 mM-1s-1) for both CA1 and CA2 at 60 MHz. Gadolinium 54-64 carbonic anhydrase 2 Homo sapiens 172-175 33783051-0 2021 Editorial for "Improved Quantification of Myocardium Scar in Late Gadolinium Enhancement Images: Deep Learning Based Image Fusion Approach". Gadolinium 66-76 ribosomal protein S4 X-linked Homo sapiens 53-57 33825259-18 2021 DATA CONCLUSION: MIPs of dynamic TWIST-MRA offer a promising diagnostic alternative necessitating only reduced amounts (50%) of gadolinium-based contrast agents for the entire runoff vasculature. Gadolinium 128-138 twist family bHLH transcription factor 1 Homo sapiens 33-38 32861792-3 2021 Restrictive policies of GBCA use in CKD and selective use of GBCAs which bind free gadolinium (Gd+3) more strongly have resulted in the virtual elimination of NSF cases. Gadolinium 83-93 GRDX Homo sapiens 95-99 33615889-0 2021 Overlapping roles of NADPH Oxidase 4 (Nox4) for diabetic and gadolinium-based contrast agent-induced systemic fibrosis. Gadolinium 61-71 NADPH oxidase 4 Mus musculus 21-36 33615889-0 2021 Overlapping roles of NADPH Oxidase 4 (Nox4) for diabetic and gadolinium-based contrast agent-induced systemic fibrosis. Gadolinium 61-71 NADPH oxidase 4 Mus musculus 38-42 33615889-4 2021 We examined the role of NADPH oxidase 4 (Nox4) in gadolinium-induced systemic disease. Gadolinium 50-60 NADPH oxidase 4 Mus musculus 24-39 33615889-4 2021 We examined the role of NADPH oxidase 4 (Nox4) in gadolinium-induced systemic disease. Gadolinium 50-60 NADPH oxidase 4 Homo sapiens 41-45 33615889-6 2021 Nox4-deficient mice were randomized to experimental diabetes and gadolinium-based contrast agent treatment. Gadolinium 65-75 NADPH oxidase 4 Mus musculus 0-4 33615889-9 2021 Deletion of Nox4 abrogated both skin and renal pathology, whether from diabetes or gadolinium-based contrast agent treatment. Gadolinium 83-93 NADPH oxidase 4 Mus musculus 12-16 33615889-10 2021 These discoveries demonstrate the importance of Nox4 in gadolinium-based contrast agent- and diabetes-induced fibrosis. Gadolinium 56-66 NADPH oxidase 4 Mus musculus 48-52 33381924-9 2021 Plasma GDF-15 levels in patients with late gadolinium enhancement-positive ATTRv amyloidosis were significantly higher than those in patients with late gadolinium enhancement-negative ATTRv amyloidosis (P < 0.01). Gadolinium 43-53 growth differentiation factor 15 Homo sapiens 7-13 33381924-9 2021 Plasma GDF-15 levels in patients with late gadolinium enhancement-positive ATTRv amyloidosis were significantly higher than those in patients with late gadolinium enhancement-negative ATTRv amyloidosis (P < 0.01). Gadolinium 152-162 growth differentiation factor 15 Homo sapiens 7-13 33599043-0 2021 Improved Quantification of Myocardium Scar in Late Gadolinium Enhancement Images: Deep Learning Based Image Fusion Approach. Gadolinium 51-61 ribosomal protein S4 X-linked Homo sapiens 38-42 33599043-1 2021 BACKGROUND: Quantification of myocardium scarring in late gadolinium enhanced (LGE) cardiac magnetic resonance imaging can be challenging due to low scar-to-background contrast and low image quality. Gadolinium 58-68 ribosomal protein S4 X-linked Homo sapiens 41-45 33643830-3 2021 A theranostic nanomedicine was designed and prepared by complexing a small gadolinium chelate, conjugating a chemotherapeutic drug PTX through a cathepsin B-responsive linker and covalently bonding a fluorescent probe pheophorbide a (Ppa) with a branched glycopolymer. Gadolinium 75-85 cathepsin B Homo sapiens 145-156 33603462-10 2021 We believe that the evaluation of OATP1B3 expression will facilitate the comprehension of imaging performance of HCC in Gd-EOB-DTPA-enhanced MRI. Gadolinium 120-122 solute carrier organic anion transporter family member 1B3 Homo sapiens 34-41 33504603-14 2021 In addition, identification of the exact contact regions between gD and gH/gL can inform the design of small molecules that would interfere with the gD-gH/gL complex formation, thus preventing the virus from entering the host cell. Gadolinium 65-67 gamma-glutamyl hydrolase Homo sapiens 72-74 31603230-2 2021 The purpose of this study was to assess whether ABO blood type is associated with galactose-deficient IgA1 (Gd-IgA1) in the progression of kidney disease in patients with IgAN. Gadolinium 108-110 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 48-51 33569363-7 2020 Our findings indicate that GFAP astrocytopathy should be considered in children who are clinically diagnosed with meningoencephalitis, whether or not myelitis is present, and if the MRI reveals enhancement of meninges or spinal cord, T2-hyperintense lesions, or a pattern of linear perivascular gadolinium enhancement. Gadolinium 295-305 glial fibrillary acidic protein Homo sapiens 27-31 31603230-2 2021 The purpose of this study was to assess whether ABO blood type is associated with galactose-deficient IgA1 (Gd-IgA1) in the progression of kidney disease in patients with IgAN. Gadolinium 108-110 immunoglobulin heavy constant alpha 1 Homo sapiens 102-106 33450989-3 2021 Gadolinium, as a free compound (Gd3+), is highly toxic in humans because it competes with divalent calcium (Ca2+) and magnesium (Mg2+) ions, interfering in some relevant biologic processes. Gadolinium 0-10 GRDX Homo sapiens 32-35 33439236-9 2021 Late gadolinium enhancement was present in 6 of 9 homozygous participants (67%) with absolute PAI-1 deficiency vs 0 of 8 in the control group (P = .001). Gadolinium 5-15 serpin family E member 1 Homo sapiens 94-99 33441839-3 2021 This paper presents an immuno-mass spectrometry imaging method using gadolinium (Gd)-labeled anti-dystrophin antibodies and laser ablation-inductively coupled plasma-mass spectrometry to simultaneously quantify and localize dystrophin in muscle sections. Gadolinium 69-79 dystrophin Homo sapiens 98-108 33441839-3 2021 This paper presents an immuno-mass spectrometry imaging method using gadolinium (Gd)-labeled anti-dystrophin antibodies and laser ablation-inductively coupled plasma-mass spectrometry to simultaneously quantify and localize dystrophin in muscle sections. Gadolinium 81-83 dystrophin Homo sapiens 98-108 33441839-3 2021 This paper presents an immuno-mass spectrometry imaging method using gadolinium (Gd)-labeled anti-dystrophin antibodies and laser ablation-inductively coupled plasma-mass spectrometry to simultaneously quantify and localize dystrophin in muscle sections. Gadolinium 81-83 dystrophin Homo sapiens 224-234 32995851-0 2020 Late gadolinium enhancement role in arrhythmic risk stratification of patients with LMNA cardiomyopathy: results from a long-term follow-up multicentre study. Gadolinium 5-15 lamin A/C Homo sapiens 84-88 33450989-6 2021 Consequently, under some conditions, gadolinium can be released in the interstitial space as a free Gd3+ compound with the possibility of toxicity. Gadolinium 37-47 GRDX Homo sapiens 100-103 31603230-2 2021 The purpose of this study was to assess whether ABO blood type is associated with galactose-deficient IgA1 (Gd-IgA1) in the progression of kidney disease in patients with IgAN. Gadolinium 108-110 immunoglobulin heavy constant alpha 1 Homo sapiens 111-115 31603230-3 2021 METHODS: We enrolled 1313 IgAN patients with a median of 44 months follow-up and measured the plasma Gd-IgA1 levels. Gadolinium 101-103 immunoglobulin heavy constant alpha 1 Homo sapiens 104-108 31603230-5 2021 Using the propensity score matching method, 718 IgAN patients with blood type either A or B were selected, and their data were used to assess the association of blood type and Gd-IgA1/serum complement 3 (sC3) with outcomes. Gadolinium 176-178 immunoglobulin heavy constant alpha 1 Homo sapiens 179-183 31603230-7 2021 The Gd-IgA1 levels showed trends similar to the multivariate-adjusted event-free curves for the blood types. Gadolinium 4-6 immunoglobulin heavy constant alpha 1 Homo sapiens 7-11 31603230-8 2021 However, this higher risk of adverse outcomes in type A than in type B patients was no longer significant after the addition of Gd-IgA1/sC3 to the model. Gadolinium 128-130 immunoglobulin heavy constant alpha 1 Homo sapiens 131-135 31603230-9 2021 CONCLUSIONS: IgAN patients with blood type A had a higher risk of adverse outcomes than those with type B, and this risk was associated with Gd-IgA1/sC3. Gadolinium 141-143 immunoglobulin heavy constant alpha 1 Homo sapiens 144-148 33407484-9 2021 The PSM had higher prevalence and amount of late gadolinium enhancement (LGE) in the left ventricle (LV). Gadolinium 49-59 folate hydrolase 1B (pseudogene) Homo sapiens 4-7 33040183-2 2021 Nanoparticles based on human serum albumin, bearing gadolinium and designed for use in magnetic resonance imaging, were used to generate magnet resonance images (MRI) of the vascular system in rats ("blood pool imaging"). Gadolinium 52-62 albumin Rattus norvegicus 29-42 32995851-1 2020 AIMS: We aimed at addressing the role of late gadolinium enhancement (LGE) in arrhythmic risk stratification of LMNA-associated cardiomyopathy (CMP). Gadolinium 46-56 lamin A/C Homo sapiens 112-116 33185633-4 2020 An initial attempt to utilize the bifunctional coordination ability of the omega-(1H-tetrazol-1-yl) carboxylic acids for preparation of mixed-metallic 3d-4f coordination polymers resulted in a novel one-dimensional gadolinium-oxo chain system with the omega-(1H-tetrazol-1-yl) carboxylic acid acting as mu2-eta2:eta1 chelating-bridging ligand. Gadolinium 215-225 adaptor related protein complex 1 subunit mu 2 Homo sapiens 303-306 33185633-4 2020 An initial attempt to utilize the bifunctional coordination ability of the omega-(1H-tetrazol-1-yl) carboxylic acids for preparation of mixed-metallic 3d-4f coordination polymers resulted in a novel one-dimensional gadolinium-oxo chain system with the omega-(1H-tetrazol-1-yl) carboxylic acid acting as mu2-eta2:eta1 chelating-bridging ligand. Gadolinium 215-225 DNA polymerase iota Homo sapiens 307-311 33185633-4 2020 An initial attempt to utilize the bifunctional coordination ability of the omega-(1H-tetrazol-1-yl) carboxylic acids for preparation of mixed-metallic 3d-4f coordination polymers resulted in a novel one-dimensional gadolinium-oxo chain system with the omega-(1H-tetrazol-1-yl) carboxylic acid acting as mu2-eta2:eta1 chelating-bridging ligand. Gadolinium 215-225 secreted phosphoprotein 1 Homo sapiens 312-316 32347397-2 2020 Herewith, the relaxivity measurements were done on a series of suspensions with the gadolinium content varied by changing number of Gd3+ ions grafted per each DND particle whereas the DND content in each suspension was kept the same. Gadolinium 84-94 GRDX Homo sapiens 132-135 32634545-3 2020 MATERIALS AND METHODS: To address these challenges, we sought to conjugate gadolinium-based ultra-small (<5 nm) NPs to an antibody directed against the oncogenic MUC1-C subunit that is overexpressed on the surfaces of many different human cancer types. Gadolinium 75-85 mucin 1, cell surface associated Homo sapiens 162-166 32634545-5 2020 As such, we examined whether systemically administered anti-MUC1-C antibody-conjugated, gadolinium-based NPs (anti-MUC1-C/NPs) could accumulate within cell-line xenograft models of MUC1-C-expressing (H460) lung and (E0771) breast cancers to improve the efficacy of radiation therapy (XRT). Gadolinium 88-98 mucin 1, cell surface associated Homo sapiens 115-119 32979460-8 2020 Alternatively, incubation with gadolinium (a cationic channel blocker) during overpressure, demonstrated a role for cationic transduction in reducing the increased levels of proliferating cell nuclear antigen that occur at 24 h post-stimulation. Gadolinium 31-41 proliferating cell nuclear antigen Homo sapiens 174-208 33247185-8 2020 MRI-based measurements of the elastin probe significantly correlated with the ex vivo elastinstain (R = .84; P <0 .001) and absolute gadolinium concentrations (ICP-MS: R = .73, P <0 .01). Gadolinium 133-143 elastin Oryctolagus cuniculus 30-37 32979460-11 2020 The overproduction of NOX4 was counteracted by gadolinium during overpressure exposure. Gadolinium 47-57 NADPH oxidase 4 Homo sapiens 22-26 32931635-0 2020 Reproducibility of Clinical Late Gadolinium Enhancement Magnetic Resonance Imaging in Detecting Left Atrial Scar after Atrial Fibrillation Ablation. Gadolinium 33-43 ribosomal protein S4 X-linked Homo sapiens 108-112 33073797-2 2020 Replacement of a proportion of the cerium chloride in synthesis by a second lanthanide chloride yields a set of materials Ce1-xLnx(OH)2Cl for Ln = La, Pr, Gd, Tb. Gadolinium 155-157 carboxylesterase 1 Homo sapiens 122-125 31789820-9 2020 The serum level of Gd-IgA1 and intensity of glomerular Gd-IgA1 staining in IgA deposition AAV patients were similar to IgA nephropathy patients. Gadolinium 19-21 immunoglobulin heavy constant alpha 1 Homo sapiens 22-26 31789820-9 2020 The serum level of Gd-IgA1 and intensity of glomerular Gd-IgA1 staining in IgA deposition AAV patients were similar to IgA nephropathy patients. Gadolinium 55-57 immunoglobulin heavy constant alpha 1 Homo sapiens 58-62 33176396-0 2020 Assessing the accuracy of conventional gadolinium-enhanced breast MRI in measuring the nodal response to neoadjuvant chemotherapy (NAC) in breast cancer. Gadolinium 39-49 nodal growth differentiation factor Homo sapiens 87-92 32931635-1 2020 BACKGROUND: Late gadolinium enhancement (LGE) cardiac MRI can be used to detect post-ablation atrial scar (PAAS) but its reproducibility and reliability in clinical scans across different magnetic flux densities and scar detection methods is unknown. Gadolinium 17-27 ribosomal protein S4 X-linked Homo sapiens 101-105 32773689-8 2020 At these concentrations, isoflurane increased activity of Phox2b-expressing retrotrapezoid nucleus neurons from 1.1 +- 0.2 to 2.8 +- 0.2 Hz (P < 0.001, n = 5), which was eliminated by bath application of gadolinium or genetic silencing of sodium leak channel. Gadolinium 204-214 paired-like homeobox 2b Mus musculus 58-64 33139643-2 2020 Although hydrophilic gadolinium (III) (Gd3+) complex-based MRCAs have achieved great success in clinical practice, the Gd3+-complexes have several inherent drawbacks including Gd3+ leakage and short blood circulation time, resulting in the potential long-term toxicity and narrow imaging time window, respectively. Gadolinium 21-31 GRDX Homo sapiens 39-42 32827972-1 2020 Glial fibrillary acidic protein is a recently identified rare cause of autoimmune encephalomyelitis, in which the cerebrospinal fluid shows lymphocytic pleocytosis accompanied by linear perivascular radial gadolinium enhancement in the brain. Gadolinium 206-216 glial fibrillary acidic protein Homo sapiens 0-31 32666643-0 2020 Case series: LMNA-related dilated cardiomyopathy presents with reginal wall akinesis and transmural late gadolinium enhancement. Gadolinium 105-115 lamin A/C Homo sapiens 13-17 32812623-4 2020 This constructed transferrin modified gadolinium-iron chelate nanoprobe, named as TUG, shows high biocompatibility within a given dose range. Gadolinium 38-48 transferrin Homo sapiens 17-28 32999398-1 2020 In these preclinical studies, we describe ADx-001, an Abeta-targeted liposomal macrocyclic gadolinium (Gd) imaging agent, for MRI of amyloid plaques. Gadolinium 91-101 amyloid beta precursor protein Rattus norvegicus 54-59 33000405-8 2022 TBRMEAN values within areas of late gadolinium enhancement provided discrimination between patients with ATTR (1.36 +- 0.23) and all other groups (e.g., AL [1.06 +- 0.07, P = .003]). Gadolinium 36-46 transthyretin Homo sapiens 105-109 32987721-1 2020 Paramagnetic metal ion complexes, mostly based on gadolinium (Gd3+), have been used for over 30 years as magnetic resonance imaging (MRI) contrast agents. Gadolinium 50-60 GRDX Homo sapiens 62-65 32495785-1 2020 Owing to the large spin-orbit coupling and tunable magnetization, heavy rare-earth metals Gd and Tb have great effects on the enhancement of spin-orbit torque (SOT) and fast domain wall (DW) motion. Gadolinium 90-92 spindlin 1 Homo sapiens 19-23 32995114-4 2020 The Pt-decorated MOF@GNSs (PtMGs) are further functionalized with human serum albumin-chelated gadolinium (HSA-Gd, HGd) and loaded with indocyanine green (ICG) (ICG-PtMGs@HGd) to achieve a synergistic PDT/PTT effect and fluorescence (FL)/multispectral optoacoustic tomography (MSOT)/X-ray computed tomography (CT)/magnetic resonance (MR) imaging. Gadolinium 95-105 albumin Homo sapiens 78-85 32660093-5 2020 A recent addition to this growing list of nanoparticles is mesoporous silica-based nanoparticles (MSNs) containing gadolinium (Gd-MSN). Gadolinium 115-125 moesin Homo sapiens 98-101 31823277-1 2020 OBJECTIVE: We try to establish designs for the macromolecular agents possessing high Gd3+-chelating stability, because free Gd3+ ion released from Gd chelates is known as a risk factor to cause toxic side effects and a safety concern. Gadolinium 85-87 GRDX Homo sapiens 124-127 32624524-8 2020 In addition, the FHx group had a higher prevalence of a diffuse late gadolinium enhancement (LGE) pattern than the no-FHx group (32% vs. 17%, P=0.022). Gadolinium 69-79 forkhead box J2 Homo sapiens 17-20 32545964-0 2020 Gadolinium-Based Neuroprognostic Magnetic Resonance Imaging Agents Suppress COX-2 for Prevention of Reperfusion Injury after Stroke. Gadolinium 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 76-81 32545964-5 2020 Our results demonstrated that gadolinium-based MRI contrast agents conjugated with NSAIDs suppressed the increase in cyclooxygenase-2 (COX-2) levels, ameliorated glial activation, and neuron damage that are phenotypic for stroke by mitigating neuroinflammation, which prevented reperfusion injury. Gadolinium 30-40 prostaglandin-endoperoxide synthase 2 Homo sapiens 117-133 32545964-5 2020 Our results demonstrated that gadolinium-based MRI contrast agents conjugated with NSAIDs suppressed the increase in cyclooxygenase-2 (COX-2) levels, ameliorated glial activation, and neuron damage that are phenotypic for stroke by mitigating neuroinflammation, which prevented reperfusion injury. Gadolinium 30-40 prostaglandin-endoperoxide synthase 2 Homo sapiens 135-140 32305437-3 2020 CatA could be stably inhibited by low microM to high nM concentrations of racemic sarin (GB), soman (GD), cyclosarin (GF), VX, and VR within minutes to hours at pH 7. Gadolinium 101-103 cathepsin A Homo sapiens 0-4 32495785-1 2020 Owing to the large spin-orbit coupling and tunable magnetization, heavy rare-earth metals Gd and Tb have great effects on the enhancement of spin-orbit torque (SOT) and fast domain wall (DW) motion. Gadolinium 90-92 spindlin 1 Homo sapiens 141-145 32372669-8 2020 LV late gadolinium enhancement (LGE) was present in a primarily subepicardial distribution in 40% of DSP patients (23/57 with MRIs). Gadolinium 8-18 desmoplakin Homo sapiens 101-104 31842616-2 2020 Gd2O3@PCD-FA was fully characterised by FTIR, vibrating sample magnetometer, TGA, XRD, SEM and TEM analyses. Gadolinium 0-5 T-box transcription factor 1 Homo sapiens 77-80 32182490-8 2020 Furthermore, based on brain tumor imaging at UHF, Apo-DyL can significantly enhance the tumor for a lower dose of the CA than the previously reported Gd- or Mn-loaded apoferritin nanoplatform. Gadolinium 150-152 ferritin heavy chain 1 Homo sapiens 167-178 32637369-1 2020 Background: Gadolinium (Gd3+) is a chemical element belonging to the lanthanide group and commonly used in magnetic resonance imaging (MRI) as a contrast agent. Gadolinium 12-22 GRDX Homo sapiens 24-27 32637296-13 2020 Mice were scanned on a 3T MR scanner (Philips Achieva) with the novel SPION contrast agent, and an elastin-targeted gadolinium agent that was shown previously to enable visualisation of plaque burden. Gadolinium 116-126 elastin Mus musculus 99-106 32637296-19 2020 In vivo results show that the novel contrast agent accumulates in similar vascular regions to a gadolinium-based contrast agent (Gd-ESMA) targeted to elastin, which accumulates in plaque. Gadolinium 96-106 elastin Mus musculus 150-157 32408647-1 2020 The reaction of the Schiff base ligand o-OH-C6H4-CH=N-C(CH2OH)3, H4L, with Ni(O2CMe)2 4H2O and lanthanide nitrate salts in a 4 : 2 : 1 ratio lead to the formation of the trinuclear complexes [Ni2Ln(H3L)4(O2CMe)2](NO3) (Ln = Sm (1), Eu (2), Gd (3), Tb (4)). Gadolinium 240-242 H4 clustered histone 7 Homo sapiens 65-68 32129393-6 2020 The coordination polymers with an optimized molar ratio of Gd/Fe exhibit an ultra-small hydrodynamic diameter (~23 nm), a high r1 value (9.3 mM-1 s-1) with low r2/r1 (1.26) and high photothermal conversion efficiency (eta = 37%). Gadolinium 59-61 endothelin receptor type A Mus musculus 218-221 32561800-7 2020 Phosphorylated-ERK1/2 levels indicated that ghrelin reduced neuronal activation induced by GD in nodose ganglion. Gadolinium 91-93 ghrelin and obestatin prepropeptide Rattus norvegicus 44-51 32004584-4 2020 The Gd-metallofullerenol provoked the Th1 immune response by regulating the M1 macrophage polarization and the doxorubicin realized direct tumor cells killing by its cytotoxic effect. Gadolinium 4-24 negative elongation factor complex member C/D Homo sapiens 38-41 32126545-3 2020 The Col-Gd@Tub NCs were spontaneously formed via tubulin self-assembly, subsequently were functionalized by colchicine and gadolinium element. Gadolinium 123-133 TUB bipartite transcription factor Homo sapiens 11-14 32126545-4 2020 These resultant Col-Gd@Tub NCs with a diameter of 45 nm exhibited uniform particle size distribution and favorable stability without leakage of gadolinium in water. Gadolinium 144-154 TUB bipartite transcription factor Homo sapiens 23-26 31912931-5 2020 The addition of 300 microM GdCl3 , which inhibits various channels including CALHM1 channels, significantly inhibited biocytin labeling in nominally Ca2+ -free saline, whereas the addition of 20 microM ruthenium red did not. Gadolinium 27-32 calcium homeostasis modulator 1 Mus musculus 77-83 32179677-1 2020 Described here is the development of gadolinium(III) texaphyrin-platinum(IV) conjugates capable of overcoming platinum resistance by 1) localizing to solid tumors, 2) promoting enhanced cancer cell uptake, and 3) reactivating p53 in platinum-resistant models. Gadolinium 37-47 transformation related protein 53, pseudogene Mus musculus 226-229 31705676-2 2020 GdCl3 (CaSR agonist) significantly increased the proliferation rate of MG-63 cells, the expression of PCNA and Cyclin D1 and decreased the expression of p21Cip/WAF-1 . Gadolinium 0-5 calcium sensing receptor Homo sapiens 7-11 32072328-3 2020 In the present study, a yeast two-hybrid screen identified a homologue of human replication factor C subunit 1 (RFC1) as a novel interacting protein of Giardia duodenalis GdTRBD (Giardia duodenalis telomerase ribonucleoprotein complex RNA binding domain GdTRBD). Gadolinium 171-177 replication factor C subunit 1 Homo sapiens 80-110 31705676-2 2020 GdCl3 (CaSR agonist) significantly increased the proliferation rate of MG-63 cells, the expression of PCNA and Cyclin D1 and decreased the expression of p21Cip/WAF-1 . Gadolinium 0-5 proliferating cell nuclear antigen Homo sapiens 102-106 31705676-2 2020 GdCl3 (CaSR agonist) significantly increased the proliferation rate of MG-63 cells, the expression of PCNA and Cyclin D1 and decreased the expression of p21Cip/WAF-1 . Gadolinium 0-5 cyclin D1 Homo sapiens 111-120 31705676-2 2020 GdCl3 (CaSR agonist) significantly increased the proliferation rate of MG-63 cells, the expression of PCNA and Cyclin D1 and decreased the expression of p21Cip/WAF-1 . Gadolinium 0-5 cyclin dependent kinase inhibitor 1A Homo sapiens 160-165 31705676-4 2020 In addition, GdCl3 up-regulated the phosphorylation of ERK1/2, PI3K and Akt and the proliferation rate of MG-63 cells. Gadolinium 13-18 mitogen-activated protein kinase 3 Homo sapiens 55-61 31705676-4 2020 In addition, GdCl3 up-regulated the phosphorylation of ERK1/2, PI3K and Akt and the proliferation rate of MG-63 cells. Gadolinium 13-18 AKT serine/threonine kinase 1 Homo sapiens 72-75 31705676-5 2020 However, these effects of GdCl3 were cancelled by LY294002 (a PI3K inhibitor) or PD98059 (an ERK1/2 inhibitor). Gadolinium 26-31 mitogen-activated protein kinase 3 Homo sapiens 93-99 31831178-5 2020 The present study explored whether ORAI1 and/or STIM1 expression and, thus, SOCE and osteogenic signaling in HAoSMCs are sensitive to MgCl2 and/or GdCl3. Gadolinium 147-152 ORAI calcium release-activated calcium modulator 1 Homo sapiens 35-40 31831178-5 2020 The present study explored whether ORAI1 and/or STIM1 expression and, thus, SOCE and osteogenic signaling in HAoSMCs are sensitive to MgCl2 and/or GdCl3. Gadolinium 147-152 stromal interaction molecule 1 Homo sapiens 48-53 31831178-7 2020 As a result, 24 h exposure to beta-glycerophosphate (2 mM) significantly enhanced transcript levels of ORAI1 and STIM1 as well as SOCE, effects significantly blunted or virtually abrogated by 1.5 mM MgCl2 and by 50 muM GdCl3. Gadolinium 220-225 ORAI calcium release-activated calcium modulator 1 Homo sapiens 103-108 31831178-8 2020 In conclusion, MgCl2 and GdCl3 are powerful inhibitors of ORAI1 and STIM1 expression and store-operated Ca2+-entry, effects affecting osteogenic signalling in vascular smooth muscle cells. Gadolinium 25-30 ORAI calcium release-activated calcium modulator 1 Homo sapiens 58-63 31831178-8 2020 In conclusion, MgCl2 and GdCl3 are powerful inhibitors of ORAI1 and STIM1 expression and store-operated Ca2+-entry, effects affecting osteogenic signalling in vascular smooth muscle cells. Gadolinium 25-30 stromal interaction molecule 1 Homo sapiens 68-73 31877357-8 2020 Furthermore, immune inhibition by gadolinium chloride (GdCl3), a well-known Kupffer cell depletor, elevated hepatic Cav-1 but inhibited ferroptosis and nitrative stress under ConA exposure. Gadolinium 55-60 caveolin 1 Homo sapiens 116-121 32072328-3 2020 In the present study, a yeast two-hybrid screen identified a homologue of human replication factor C subunit 1 (RFC1) as a novel interacting protein of Giardia duodenalis GdTRBD (Giardia duodenalis telomerase ribonucleoprotein complex RNA binding domain GdTRBD). Gadolinium 171-177 replication factor C subunit 1 Homo sapiens 112-116 31872821-0 2020 Gadolinium-based MRI contrast agent for the detection of tyrosinase. Gadolinium 0-10 tyrosinase Homo sapiens 57-67 32011125-0 2020 Unusually Distorted Pseudo-Octahedral Coordination Environment Around CoII from Thioether Schiff Base Ligands in Dinuclear [CoLn] (Ln = La, Gd, Tb, Dy, Ho) Complexes: Synthesis, Structure, and Understanding of Magnetic Behavior. Gadolinium 140-142 mitochondrially encoded cytochrome c oxidase II Homo sapiens 70-74 32011125-1 2020 The synthesis, structural characterization, and magnetic behavior of a new family of binuclear CoII-LnIII complexes of formula [LnIIICoIIL2(NO3)3] H2O (Ln = La, 1; Gd, 2; Tb, 3; Dy, 4; Ho, 5; HL = 3-methoxy-N-(2-(methylsulfanyl)phenyl)salicylaldimine) have been reported. Gadolinium 164-166 mitochondrially encoded cytochrome c oxidase II Homo sapiens 95-99 32090177-5 2020 The diagnosis of autoimmune GFAP astrocytopathy was made based on the typical MRI findings of periventricular radial linear gadolinium enhancement in the brain and longitudinally extensive lesions in the spinal cord, and anti-GFAP antibody detected in the cerebrospinal fluid. Gadolinium 124-134 glial fibrillary acidic protein Homo sapiens 28-32 32019875-1 2020 OBJECTIVE: Autoimmune steroid-responsive meningoencephalomyelitis with linear perivascular gadolinium enhancement in brain MRI is regarded as glial fibrillary acidic protein (GFAP) astrocytopathy characterized by anti-GFAP antibodies (ABs). Gadolinium 91-101 glial fibrillary acidic protein Homo sapiens 142-173 32019875-1 2020 OBJECTIVE: Autoimmune steroid-responsive meningoencephalomyelitis with linear perivascular gadolinium enhancement in brain MRI is regarded as glial fibrillary acidic protein (GFAP) astrocytopathy characterized by anti-GFAP antibodies (ABs). Gadolinium 91-101 glial fibrillary acidic protein Homo sapiens 175-179 32019875-8 2020 MRIs of both patients revealed radial perivascular gadolinium enhancement extending from the lateral ventricles to the white matter suggestive of autoimmune GFAP astrocytopathy. Gadolinium 51-61 glial fibrillary acidic protein Homo sapiens 157-161 31880354-3 2020 Here, gadolinium fluoride (GdF3 ) is added into perovskite precursor as a redox shuttle and growth-assist; meanwhile, aminobutanol vapor is used for Ostwald ripening in the formation of the perovskite layer. Gadolinium 6-25 growth differentiation factor 3 Homo sapiens 27-31 31831259-0 2020 GdCl3 attenuates the glomerular sclerosis of streptozotocin (STZ) induced diabetic rats via inhibiting TGF-beta/Smads signal pathway. Gadolinium 0-5 transforming growth factor, beta 1 Rattus norvegicus 103-111 31831259-3 2020 In this study, we found that GdCl3 which was an agonist of Calcium-sensing receptor (CaSR) could repress the activation of TGF-beta/Smads signal pathway induced by TGF-beta1 or high glucose and then alleviated the accumulation of extracellular matrix (ECM) in mesangial cells and the kidney of type1 diabetic rats. Gadolinium 29-34 transforming growth factor, beta 1 Rattus norvegicus 123-131 31831259-3 2020 In this study, we found that GdCl3 which was an agonist of Calcium-sensing receptor (CaSR) could repress the activation of TGF-beta/Smads signal pathway induced by TGF-beta1 or high glucose and then alleviated the accumulation of extracellular matrix (ECM) in mesangial cells and the kidney of type1 diabetic rats. Gadolinium 29-34 transforming growth factor, beta 1 Rattus norvegicus 164-173 31831259-4 2020 Further study indicated that GdCl3 could induce the binding of CaSR and TbetaR II and then both of these two receptors translocated from cell membrane to cytoplasm, in this case, TbetaR II on the cell membrane was decreased and then desensitized to the stimulation of its ligand TGF-beta1, so that the activation of its downstream factors such as Smad2 and Smad3 were blocked, finally, ECM expression in mesangial cells were inhibited. Gadolinium 29-34 transforming growth factor, beta receptor 2 Rattus norvegicus 72-81 31831259-4 2020 Further study indicated that GdCl3 could induce the binding of CaSR and TbetaR II and then both of these two receptors translocated from cell membrane to cytoplasm, in this case, TbetaR II on the cell membrane was decreased and then desensitized to the stimulation of its ligand TGF-beta1, so that the activation of its downstream factors such as Smad2 and Smad3 were blocked, finally, ECM expression in mesangial cells were inhibited. Gadolinium 29-34 transforming growth factor, beta receptor 2 Rattus norvegicus 179-188 31831259-4 2020 Further study indicated that GdCl3 could induce the binding of CaSR and TbetaR II and then both of these two receptors translocated from cell membrane to cytoplasm, in this case, TbetaR II on the cell membrane was decreased and then desensitized to the stimulation of its ligand TGF-beta1, so that the activation of its downstream factors such as Smad2 and Smad3 were blocked, finally, ECM expression in mesangial cells were inhibited. Gadolinium 29-34 transforming growth factor, beta 1 Rattus norvegicus 279-288 31831259-4 2020 Further study indicated that GdCl3 could induce the binding of CaSR and TbetaR II and then both of these two receptors translocated from cell membrane to cytoplasm, in this case, TbetaR II on the cell membrane was decreased and then desensitized to the stimulation of its ligand TGF-beta1, so that the activation of its downstream factors such as Smad2 and Smad3 were blocked, finally, ECM expression in mesangial cells were inhibited. Gadolinium 29-34 SMAD family member 2 Rattus norvegicus 347-352 31831259-4 2020 Further study indicated that GdCl3 could induce the binding of CaSR and TbetaR II and then both of these two receptors translocated from cell membrane to cytoplasm, in this case, TbetaR II on the cell membrane was decreased and then desensitized to the stimulation of its ligand TGF-beta1, so that the activation of its downstream factors such as Smad2 and Smad3 were blocked, finally, ECM expression in mesangial cells were inhibited. Gadolinium 29-34 SMAD family member 3 Rattus norvegicus 357-362 31831259-5 2020 We concluded that GdCl3 could alleviate the accumulation of ECM in mesangial cells via antagonizing TGF-beta/Smads signal pathway in diabetes mellitus. Gadolinium 18-23 transforming growth factor, beta 1 Rattus norvegicus 100-108 31748116-1 2020 Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). Gadolinium 26-28 immunoglobulin heavy constant alpha 1 Homo sapiens 20-24 31748116-1 2020 Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). Gadolinium 26-28 immunoglobulin heavy constant alpha 1 Homo sapiens 29-33 31748116-2 2020 However, the pathogenic mechanisms driving Gd-IgA1 production have not been fully elucidated. Gadolinium 43-45 immunoglobulin heavy constant alpha 1 Homo sapiens 46-50 31748116-3 2020 Innate-immune activation via Toll-like receptor 9 (TLR9) is known to be involved in Gd-IgA1 production. Gadolinium 84-86 toll-like receptor 9 Mus musculus 29-49 31748116-3 2020 Innate-immune activation via Toll-like receptor 9 (TLR9) is known to be involved in Gd-IgA1 production. Gadolinium 84-86 toll-like receptor 9 Mus musculus 51-55 31748116-3 2020 Innate-immune activation via Toll-like receptor 9 (TLR9) is known to be involved in Gd-IgA1 production. Gadolinium 84-86 immunoglobulin heavy constant alpha 1 Homo sapiens 87-91 31748116-4 2020 A proliferation inducing ligand (APRIL) and IL-6 are also known to enhance Gd-IgA1 synthesis in IgAN. Gadolinium 75-77 tumor necrosis factor (ligand) superfamily, member 13 Mus musculus 0-31 31748116-4 2020 A proliferation inducing ligand (APRIL) and IL-6 are also known to enhance Gd-IgA1 synthesis in IgAN. Gadolinium 75-77 tumor necrosis factor (ligand) superfamily, member 13 Mus musculus 33-38 31748116-4 2020 A proliferation inducing ligand (APRIL) and IL-6 are also known to enhance Gd-IgA1 synthesis in IgAN. Gadolinium 75-77 interleukin 6 Mus musculus 44-48 31748116-4 2020 A proliferation inducing ligand (APRIL) and IL-6 are also known to enhance Gd-IgA1 synthesis in IgAN. Gadolinium 75-77 immunoglobulin heavy constant alpha 1 Homo sapiens 78-82 31748116-9 2020 However, siRNA knock-down of APRIL completely suppressed overproduction of Gd-IgA1 induced by IL-6. Gadolinium 75-77 tumor necrosis factor (ligand) superfamily, member 13 Mus musculus 29-34 31748116-9 2020 However, siRNA knock-down of APRIL completely suppressed overproduction of Gd-IgA1 induced by IL-6. Gadolinium 75-77 immunoglobulin heavy constant alpha 1 Homo sapiens 78-82 31748116-9 2020 However, siRNA knock-down of APRIL completely suppressed overproduction of Gd-IgA1 induced by IL-6. Gadolinium 75-77 interleukin 6 Mus musculus 94-98 31748116-10 2020 Neutralization of IL-6 decreased CpG-oligonucleotide-induced overproduction of Gd-IgA1. Gadolinium 79-81 interleukin 6 Mus musculus 18-22 31748116-10 2020 Neutralization of IL-6 decreased CpG-oligonucleotide-induced overproduction of Gd-IgA1. Gadolinium 79-81 immunoglobulin heavy constant alpha 1 Homo sapiens 82-86 31748116-11 2020 Furthermore, APRIL and IL-6 pathways each independently mediated TLR9-induced overproduction of Gd-IgA1. Gadolinium 96-98 tumor necrosis factor (ligand) superfamily, member 13 Mus musculus 13-18 31748116-11 2020 Furthermore, APRIL and IL-6 pathways each independently mediated TLR9-induced overproduction of Gd-IgA1. Gadolinium 96-98 interleukin 6 Mus musculus 23-27 31748116-11 2020 Furthermore, APRIL and IL-6 pathways each independently mediated TLR9-induced overproduction of Gd-IgA1. Gadolinium 96-98 toll-like receptor 9 Mus musculus 65-69 31748116-11 2020 Furthermore, APRIL and IL-6 pathways each independently mediated TLR9-induced overproduction of Gd-IgA1. Gadolinium 96-98 immunoglobulin heavy constant alpha 1 Homo sapiens 99-103 31748116-13 2020 Hence, APRIL and IL-6 synergistically, as well as independently, enhance synthesis of Gd-IgA1. Gadolinium 86-88 tumor necrosis factor (ligand) superfamily, member 13 Mus musculus 7-12 31748116-13 2020 Hence, APRIL and IL-6 synergistically, as well as independently, enhance synthesis of Gd-IgA1. Gadolinium 86-88 interleukin 6 Mus musculus 17-21 31748116-13 2020 Hence, APRIL and IL-6 synergistically, as well as independently, enhance synthesis of Gd-IgA1. Gadolinium 86-88 immunoglobulin heavy constant alpha 1 Homo sapiens 89-93 31769744-10 2020 Gadolinium retention was detected in the cerebral cortex, pia mater, and pia-ensheathed leptomeningeal vessels in two GBCA-exposed human brains but not in two GBCA-naive human brains. Gadolinium 0-10 RPTOR independent companion of MTOR complex 2 Homo sapiens 58-61 31769744-10 2020 Gadolinium retention was detected in the cerebral cortex, pia mater, and pia-ensheathed leptomeningeal vessels in two GBCA-exposed human brains but not in two GBCA-naive human brains. Gadolinium 0-10 RPTOR independent companion of MTOR complex 2 Homo sapiens 73-76 31868204-4 2020 RESULTS: The results showed that myocardial miR-221 was significantly increased (z=-2.249, p=0.024) and significantly correlated with collagen volume fraction (CVF) (r=0.516, p&lt;0.001), late gadolinium enhancement (LGE) (r=0.307, p=0.048), and peripheral circulation (r=0.434, p=0.004). Gadolinium 198-208 microRNA 221 Homo sapiens 45-52 31978954-6 2020 The promising in vitro cellular uptake of 67Ga/Gd-based bombesin containing particles was confirmed through biodistribution studies in tumor bearing mice, indicating their integrity and ability to target the GRPr. Gadolinium 47-49 gastrin releasing peptide receptor Mus musculus 208-212 31913029-4 2020 It should be noted that the pGd value of Gd-tpptac (18.4) is only slightly lower than that of commercially available MRI contrast agents such as Gd-dota (pGd = 19.2). Gadolinium 41-50 phosphoglycerate dehydrogenase Homo sapiens 28-31 31973215-4 2020 These diagnostic agents are obtained for self-assembly of DTPA(Gd)-PEG8-(FY)3 or DOTA(Gd)-PEG8-(FY)3 peptide conjugates, in which the Gd-complexes are linked at the N-terminus of the PEG8-(FY)3 polymer peptide. Gadolinium 63-65 IGF2 antisense RNA Homo sapiens 67-71 31941451-1 2020 BACKGROUND: More and more studies demonstrated that genetic variation at C1GALT1 influences Gd-IgA1 level in IgAN. Gadolinium 92-94 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Homo sapiens 73-80 31941451-1 2020 BACKGROUND: More and more studies demonstrated that genetic variation at C1GALT1 influences Gd-IgA1 level in IgAN. Gadolinium 92-94 immunoglobulin heavy constant alpha 1 Homo sapiens 95-99 31941451-1 2020 BACKGROUND: More and more studies demonstrated that genetic variation at C1GALT1 influences Gd-IgA1 level in IgAN. Gadolinium 92-94 IGAN1 Homo sapiens 109-113 31941451-2 2020 However, whether the expression of beta1, 3-galactosyltransferase (beta1, 3Gal-T) was influenced may provide insights into how Gd-IgA1 levels are controlled in IgAN. Gadolinium 127-129 immunoglobulin heavy constant alpha 1 Homo sapiens 130-134 31941451-2 2020 However, whether the expression of beta1, 3-galactosyltransferase (beta1, 3Gal-T) was influenced may provide insights into how Gd-IgA1 levels are controlled in IgAN. Gadolinium 127-129 IGAN1 Homo sapiens 160-164 31941451-4 2020 Total Gd-IgA1 levels in plasma were determined by ELISA and C1GALT1 levels were determined by RT-PCR. Gadolinium 6-8 immunoglobulin heavy constant alpha 1 Homo sapiens 9-13 31941451-7 2020 RESULTS: Gd-IgA1 levels were remarkable higher in IgAN patients compared with healthy control. Gadolinium 9-11 immunoglobulin heavy constant alpha 1 Homo sapiens 12-16 31941451-7 2020 RESULTS: Gd-IgA1 levels were remarkable higher in IgAN patients compared with healthy control. Gadolinium 9-11 IGAN1 Homo sapiens 50-54 31941451-9 2020 And the mRNA level of C1GALT1 was inversely correlated to Gd-IgA1 levels. Gadolinium 58-60 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Homo sapiens 22-29 31941451-9 2020 And the mRNA level of C1GALT1 was inversely correlated to Gd-IgA1 levels. Gadolinium 58-60 immunoglobulin heavy constant alpha 1 Homo sapiens 61-65 31941451-15 2020 CONCLUSIONS: We found expression levels of C1GALT1 were remarkably downregulated in IgAN patients and negatively correlated with higher levels of Gd-IgA1. Gadolinium 146-148 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Homo sapiens 43-50 31941451-15 2020 CONCLUSIONS: We found expression levels of C1GALT1 were remarkably downregulated in IgAN patients and negatively correlated with higher levels of Gd-IgA1. Gadolinium 146-148 immunoglobulin heavy constant alpha 1 Homo sapiens 149-153 31850230-3 2019 A targeted macrocyclic gadolinium-based contrast agent (GBCA) ZD2-N3-Gd(HP-DO3A) (MT218), specific to EDB-FN, was developed for MRMI of aggressive breast cancer. Gadolinium 23-33 fibronectin 1 Homo sapiens 102-105 32082496-5 2020 Late gadolinium enhancement extent was positively associated with cardiac troponin I serum levels and c-reactive protein and negatively with left ventricular ejection fraction at baseline study. Gadolinium 5-15 C-reactive protein Homo sapiens 102-120 33216687-8 2020 MR-imaging was performed using an elastin-specific gadolinium-based-probe (0.2 mmol/kg). Gadolinium 51-61 elastin Mus musculus 34-41 31850230-5 2019 At clinical dose of 0.1 and subclinical dose of 0.04 mmol Gd/kg, MT218 rapidly bound to the extracellular matrix EDB-FN and produced robust tumor contrast enhancement in both the tumor models, as early as 1-30 min post-injection. Gadolinium 58-60 fibronectin 1 Homo sapiens 113-116 31793901-0 2019 Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin. Gadolinium 51-61 afamin Homo sapiens 125-131 31738019-2 2019 Herein, a biocompatible theranostic nanoplatform capable of simultaneous cancer imaging and therapy is attempted by loading of paclitaxel (PTX) and indocyanine green (ICG) molecules into the matrix of Gd2 O3 @human serum albumin (HSA) nanoparticles (PIGH NPs) via hydrophobic interaction. Gadolinium 201-207 phosphatidylinositol glycan anchor biosynthesis, class H Mus musculus 250-254 31776956-5 2019 At negative potentials, Gd3+ decreased IK1 and inward current including IMGCh. Gadolinium 24-28 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 39-42 31684723-7 2019 Furthermore, the Gd-HM-Dox/34a exhibited augmented accumulation in tumor tissue, which improved the MRI-contrast of solid tumors and enhanced the combined efficiency of chemotherapeutic drugs Dox and therapeutic gene miR-34a in suppressing tumor growth in MDA-MB-231 tumor-bearing mice. Gadolinium 17-19 microRNA 34a Mus musculus 217-224 31674789-0 2019 BMP-2 Loaded HAp:Ln3+ (Ln = Yb, Er, Gd) Nanorods with Dual Modal Imaging for Efficient MC3t3-E1 Cells Differentiation Regulation. Gadolinium 36-38 bone morphogenetic protein 2 Mus musculus 0-5 31674789-5 2019 In this study, Ln3+ (Ln=Yb3+, Er3+, Gd3+) doped HAp (HAP:Ln3+) nanorods were synthesized by one-step hydrothermal method. Gadolinium 36-40 scaffold attachment factor B Mus musculus 48-51 31674789-5 2019 In this study, Ln3+ (Ln=Yb3+, Er3+, Gd3+) doped HAp (HAP:Ln3+) nanorods were synthesized by one-step hydrothermal method. Gadolinium 36-40 scaffold attachment factor B Mus musculus 53-56 31674789-9 2019 Furthermore, due to the positive magnetism correlated with the concentration of Gd3+, the HAP:Ln3+ with enhanced contrast brightening can be deemed as T1 MIR contrast agents. Gadolinium 80-84 scaffold attachment factor B Mus musculus 90-93 31650133-6 2019 We conducted a proof-of-concept study to demonstrate that ultra-small (<5 nm) gadolinium-containing nanoparticles bound to full-length antibodies against the B-cell maturation antigen (BCMA) exhibit rapid tumor uptake followed by renal clearance, improving the signal-to-noise ratio for MM detection beyond levels that are currently afforded by other FDA-approved clinical imaging modalities. Gadolinium 78-88 TNF receptor superfamily member 17 Homo sapiens 158-183 31650133-6 2019 We conducted a proof-of-concept study to demonstrate that ultra-small (<5 nm) gadolinium-containing nanoparticles bound to full-length antibodies against the B-cell maturation antigen (BCMA) exhibit rapid tumor uptake followed by renal clearance, improving the signal-to-noise ratio for MM detection beyond levels that are currently afforded by other FDA-approved clinical imaging modalities. Gadolinium 78-88 TNF receptor superfamily member 17 Homo sapiens 185-189 31586031-6 2019 Yoda1-induced Ca2+ entry was inhibited by Piezo1 blockers (gadolinium and ruthenium red) and was reduced proportionally by siRNA-mediated Piezo1 knockdown or in murine Piezo1 +/- cells. Gadolinium 59-69 piezo-type mechanosensitive ion channel component 1 Mus musculus 42-48 31727077-8 2019 Consistent increase of miR-21 and miR-146a/b was found in Gd+ MS patients. Gadolinium 58-60 microRNA 21 Homo sapiens 23-29 31727077-8 2019 Consistent increase of miR-21 and miR-146a/b was found in Gd+ MS patients. Gadolinium 58-60 microRNA 146a Homo sapiens 34-42 31727906-9 2019 Yoda1 evoked Ca2+ entry was inhibited by Yoda1 antagonist Dooku1 as well as other Piezo1 inhibitors gadolinium and ruthenium red, and not mimicked by 2e. Gadolinium 100-110 piezo-type mechanosensitive ion channel component 1 Mus musculus 82-88 31763443-5 2020 S-SERCA2 increased in the presence of late gadolinium enhancement on cardiac magnetic resonance imaging. Gadolinium 43-53 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Homo sapiens 2-8 32043030-8 2020 Co-localized IgA1 and Gd-IgA1 of both secondary and primary IgAN indicated that they both share the feature of Gd-IgA1 deposits on the glomerular mesangium. Gadolinium 111-113 immunoglobulin heavy constant alpha 1 Homo sapiens 13-17 31415758-5 2019 This effect was abolished by treating cells with mechano-gated channel inhibitors, such as gadolinium, transient receptor potential (TRP) family inhibitor, ruthenium red, and with pharmacological and small interfering RNA-mediated TRPV1 inhibition. Gadolinium 91-101 transient receptor potential cation channel subfamily V member 1 Homo sapiens 231-236 31633669-3 2019 METHODS: ITK-SNAP was utilized for semiautomatic image segmentation of 58 gadolinium-contrast enhanced T1-weighted thin-slice MRI datasets for volumetric analysis. Gadolinium 74-84 IL2 inducible T cell kinase Homo sapiens 9-12 30978353-2 2019 Bone marrow-derived fibrocytes and the monocyte chemoattractant protein-1 inflammatory pathway have been implicated as mediators of the adverse effects induced by gadolinium-based contrast agents. Gadolinium 163-173 chemokine (C-C motif) ligand 2 Mus musculus 39-73 31356957-5 2019 The second family is based on the formation of gadolinium particles (Gd2O3, GdPO4, NaGdF4, GdF3...) of controlled morphology and composition. Gadolinium 47-57 growth differentiation factor 3 Homo sapiens 91-95 31478802-6 2019 Mice were imaged with bis-5-hydroxytryptamide-diethylenetriaminepentaacetate gadolinium (hereafter, MPO-Gd) MRI. Gadolinium 77-87 myeloperoxidase Mus musculus 100-103 30239314-9 2019 Cox regression analysis demonstrated that low coverage of hDS by T1Gd with a 2-cm margin was predictive of disease recurrence outside the Gd-enhanced core lesion, indicative of out-of-field reoccurrence.CONCLUSIONSThe findings of this study indicate that MRI is inadequate for target delineation for RT in malignant glioma treatment. Gadolinium 67-69 dehydrodolichyl diphosphate synthase subunit Homo sapiens 58-61 31554825-6 2019 MR imaging was performed before and after administration of an elastin-specific gadolinium-based and a macrophage-specific iron-oxide-based probe. Gadolinium 80-90 elastin Mus musculus 63-70 31608004-7 2019 In RRMS and SPMS patients, increased NFL levels were associated with clinical relapse, and gadolinium-enhanced lesions in MRI (p < 0.001), while high CHI3L1 levels were characteristic of progressive disease (p = 0.01). Gadolinium 91-101 neurofilament light chain Homo sapiens 37-40 31499945-7 2019 The osteogenic-related genes such as alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2) and collagen type1 (COL-1) were remarkably up-regulated by Gd-MCS scaffolds as compared with MCS scaffolds, and their expression levels increased in a positive correlation with Gd doping amounts. Gadolinium 168-170 alkaline phosphatase, placental Homo sapiens 37-57 31499945-7 2019 The osteogenic-related genes such as alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2) and collagen type1 (COL-1) were remarkably up-regulated by Gd-MCS scaffolds as compared with MCS scaffolds, and their expression levels increased in a positive correlation with Gd doping amounts. Gadolinium 168-170 alkaline phosphatase, placental Homo sapiens 59-62 31499945-7 2019 The osteogenic-related genes such as alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2) and collagen type1 (COL-1) were remarkably up-regulated by Gd-MCS scaffolds as compared with MCS scaffolds, and their expression levels increased in a positive correlation with Gd doping amounts. Gadolinium 168-170 RUNX family transcription factor 2 Homo sapiens 65-100 31499945-7 2019 The osteogenic-related genes such as alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2) and collagen type1 (COL-1) were remarkably up-regulated by Gd-MCS scaffolds as compared with MCS scaffolds, and their expression levels increased in a positive correlation with Gd doping amounts. Gadolinium 168-170 RUNX family transcription factor 2 Homo sapiens 102-107 31506457-3 2019 Here we show how the combination of spectroscopically distinguishable nitroxide and gadolinium spin labels and Double Electron-Electron Resonance can help to gain new insights into the quaternary structure of active, membrane-embedded Bax oligomers. Gadolinium 84-94 BCL2 associated X, apoptosis regulator Homo sapiens 235-238 31395665-0 2019 Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging. Gadolinium 28-38 colony stimulating factor 2 Homo sapiens 50-53 31395665-2 2019 We explored the optimal FLAIR sequence parameters for the detection of low gadolinium concentrations within the CSF. Gadolinium 75-85 colony stimulating factor 2 Homo sapiens 112-115 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 134-136 immunoglobulin heavy constant alpha 1 Homo sapiens 101-105 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 134-136 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 134-136 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31844808-6 2019 Sera and cell-culture supernatants were used for analysis of Gd-IgA1 and Gd-IgA1-specific IgG autoantibodies. Gadolinium 61-63 immunoglobulin heavy constant alpha 1 Homo sapiens 64-68 31844808-6 2019 Sera and cell-culture supernatants were used for analysis of Gd-IgA1 and Gd-IgA1-specific IgG autoantibodies. Gadolinium 73-75 immunoglobulin heavy constant alpha 1 Homo sapiens 76-80 31844808-7 2019 Results: IgA1-producing cells from patients with IgAV-N, like cells from patients with IgAN, secreted more Gd-IgA1 than did cells from patients with IgAV-woN or healthy control subjects, in agreement with elevated serum Gd-IgA1 levels in patients with IgAV-N and IgAN. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 9-13 31844808-7 2019 Results: IgA1-producing cells from patients with IgAV-N, like cells from patients with IgAN, secreted more Gd-IgA1 than did cells from patients with IgAV-woN or healthy control subjects, in agreement with elevated serum Gd-IgA1 levels in patients with IgAV-N and IgAN. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31844808-7 2019 Results: IgA1-producing cells from patients with IgAV-N, like cells from patients with IgAN, secreted more Gd-IgA1 than did cells from patients with IgAV-woN or healthy control subjects, in agreement with elevated serum Gd-IgA1 levels in patients with IgAV-N and IgAN. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31844808-7 2019 Results: IgA1-producing cells from patients with IgAV-N, like cells from patients with IgAN, secreted more Gd-IgA1 than did cells from patients with IgAV-woN or healthy control subjects, in agreement with elevated serum Gd-IgA1 levels in patients with IgAV-N and IgAN. Gadolinium 220-222 immunoglobulin heavy constant alpha 1 Homo sapiens 9-13 31844808-9 2019 Levels of Gd-IgA1-specific IgG in sera and supernatants of IgG-producing cells were similar for patients with IgAV-N and IgAN and higher than those for IgAV-woN patients or healthy control subjects. Gadolinium 10-12 immunoglobulin heavy constant alpha 1 Homo sapiens 13-17 31844808-10 2019 Moreover, patients with IgAV-N who had active disease, manifested by hematuria and substantial proteinuria, had higher serum levels of Gd-IgA1-specific IgG autoantibodies than did patients with IgAV-N who had inactive disease. Gadolinium 135-137 immunoglobulin heavy constant alpha 1 Homo sapiens 138-142 31844808-11 2019 Conclusion: Serum levels and cellular production of Gd-IgA1 and Gd-IgA1-specific IgG autoantibodies were elevated in patients with IgAV-N, supporting the hypothesis that IgAV-N and IgAN share pathogenic features. Gadolinium 52-54 immunoglobulin heavy constant alpha 1 Homo sapiens 55-59 31844808-11 2019 Conclusion: Serum levels and cellular production of Gd-IgA1 and Gd-IgA1-specific IgG autoantibodies were elevated in patients with IgAV-N, supporting the hypothesis that IgAV-N and IgAN share pathogenic features. Gadolinium 64-66 immunoglobulin heavy constant alpha 1 Homo sapiens 67-71 31379173-4 2019 Herein, a gadolinium/adenosine monophosphate (Gd3+/AMP) shell was formed on liposomes (liposome@Gd3+/AMP) using lipids containing phosphoserine (PS) or cholinephosphate (CP) headgroups, while phosphocholine liposomes did not support the shell. Gadolinium 10-20 GRDX Homo sapiens 46-49 31379173-4 2019 Herein, a gadolinium/adenosine monophosphate (Gd3+/AMP) shell was formed on liposomes (liposome@Gd3+/AMP) using lipids containing phosphoserine (PS) or cholinephosphate (CP) headgroups, while phosphocholine liposomes did not support the shell. Gadolinium 10-20 GRDX Homo sapiens 96-99 31132643-2 2019 In this article, an internally hydroxy dendrimer of high molecular weight was facilely synthesized by "epoxy-amine" and "thiol-ene" reactions with a beta-cyclodextrin (beta-CD) as the core, and a hypoxia-targeting dendritic contrast agent (DCA) was synthesized through conjugating Gd chelates onto the internal hydroxyl groups and grafting the hypoxia-targeting groups sulfonamides and zwitterionic groups onto the exterior groups of the dendrimer. Gadolinium 281-283 beta-carotene oxygenase 1 Mus musculus 168-175 31138020-8 2019 Indexed late gadolinium enhancement significantly decreased in G-CSF group only (P=0.04). Gadolinium 13-23 colony stimulating factor 3 Homo sapiens 63-68 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 101-105 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31046780-0 2019 Myocardial fibrosis by late gadolinium enhancement cardiovascular magnetic resonance in myotonic muscular dystrophy type 1: highly prevalent but not associated with surface conduction abnormality. Gadolinium 28-38 dysferlin Homo sapiens 88-122 30991180-2 2019 Here, we developed a molybdenum disulfide (MoS2)-based hyaluronic acid (HA)-functionalized nanoplatform capable of achieving the targeted co-delivery of the gadolinium (Gd)-based contrast agents (CAs) and the anticancer drug gefitinib (Gef) for magnetic resonance imaging (MRI) and synergetic chemo-photothermal therapy of tumors. Gadolinium 157-167 mago homolog, exon junction complex core component Mus musculus 43-47 30991180-2 2019 Here, we developed a molybdenum disulfide (MoS2)-based hyaluronic acid (HA)-functionalized nanoplatform capable of achieving the targeted co-delivery of the gadolinium (Gd)-based contrast agents (CAs) and the anticancer drug gefitinib (Gef) for magnetic resonance imaging (MRI) and synergetic chemo-photothermal therapy of tumors. Gadolinium 169-171 mago homolog, exon junction complex core component Mus musculus 43-47 31028886-3 2019 A dual-modality imaging probe (PP1-Au@GSH@Gd NCs) was constructed by covalently attaching a peptidic SR-AI ligand, PP1 to gadolinium-integrated gold nanoclusters, which exhibited remarkably improved fluorescence signal and longitudinal relaxivity with highly loaded Au and Gd species. Gadolinium 122-132 protein phosphatase 1 catalytic subunit gamma Mus musculus 31-34 31028886-3 2019 A dual-modality imaging probe (PP1-Au@GSH@Gd NCs) was constructed by covalently attaching a peptidic SR-AI ligand, PP1 to gadolinium-integrated gold nanoclusters, which exhibited remarkably improved fluorescence signal and longitudinal relaxivity with highly loaded Au and Gd species. Gadolinium 122-132 macrophage scavenger receptor 1 Mus musculus 101-106 31028886-3 2019 A dual-modality imaging probe (PP1-Au@GSH@Gd NCs) was constructed by covalently attaching a peptidic SR-AI ligand, PP1 to gadolinium-integrated gold nanoclusters, which exhibited remarkably improved fluorescence signal and longitudinal relaxivity with highly loaded Au and Gd species. Gadolinium 122-132 protein phosphatase 1 catalytic subunit gamma Mus musculus 115-118 31179770-0 2021 Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies. Gadolinium 0-10 paraoxonase 1 Homo sapiens 43-56 30215189-3 2019 The influence of gadolinium-based CAs on plasma hemostasis was evaluated by measuring PT (prothrombin time), APTT (activated partial tromboplastin time), and TT (thrombin time). Gadolinium 17-27 coagulation factor II, thrombin Homo sapiens 93-101 31019180-5 2019 All statistical data were analyzed by SPSS version 21.0.The percentage of late gadolinium enhancement (LGE) was negatively correlated with apelin and positively correlated with cTNI, maximum wall thickness (MWT), and left ventricular mass index in the overall patients with HCM and LGE. Gadolinium 79-89 apelin Homo sapiens 139-145 31019180-5 2019 All statistical data were analyzed by SPSS version 21.0.The percentage of late gadolinium enhancement (LGE) was negatively correlated with apelin and positively correlated with cTNI, maximum wall thickness (MWT), and left ventricular mass index in the overall patients with HCM and LGE. Gadolinium 79-89 troponin I3, cardiac type Homo sapiens 177-181 31133696-7 2019 In contrast, APOE4 carriers had an increased burden of cerebral disease involvement as determined by MRI severity score (10.5 vs 7.0 points, p = 0.01), higher gadolinium intensity score (2.0 vs 1.3 points, p = 0.007), inferior neurologic function (neurologic function score 2.4 vs 1.0, p = 0.001), and elevated CSF MMP2 levels compared to that of non-carriers (13168 vs 9472 pg/mL, p = 0.01). Gadolinium 159-169 apolipoprotein E Homo sapiens 13-18 30672844-5 2019 Oatp1a1 operates by transporting gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) into cells, and it concomitantly improves BLI substrate uptake. Gadolinium 33-43 solute carrier organic anion transporter family, member 1a1 Mus musculus 0-7 30737333-3 2019 RESULTS: At baseline, NfL levels (pg/mL) were higher in patients than in healthy controls (30.5 and 27.0 vs 16.9, p = 0.0001) and correlated with T2 lesion load and number of gadolinium-enhancing T1 lesions (p < 0.0001, both). Gadolinium 175-185 neurofilament light chain Homo sapiens 22-25 30956705-13 2019 We consider it essential to perform an MRI with gadolinium to rule out cases of BPPV that have a central cause. Gadolinium 48-58 benign paroxysmal positional vertigo Homo sapiens 80-84 30935572-8 2019 For DCE images, the accuracy ranged from 12.8 to 35.8% for a gadolinium concentration of 0.5 mM and deteriorated for higher concentrations. Gadolinium 61-71 24-dehydrocholesterol reductase Homo sapiens 4-7 30771578-9 2019 The NFL levels of CSF in the CIS, MS and NMOSD groups were correlated with the expanded disability status scale score and enhancement in gadolinium-magnetic resonance imaging (all P < 0.05). Gadolinium 137-147 neurofilament light chain Homo sapiens 4-7 30737648-5 2019 In H9c2 rat cardiomyoblasts cultured with serum-free medium, GD significantly augmented eEF2 phosphorylation and signals related to autophagy [increase of microtubule-associated protein 1 light chain 3 (LC3)-II to LC3-I ratio] and apoptosis (cleavage of caspase-3) as determined by Western blotting. Gadolinium 61-63 eukaryotic translation elongation factor 2 Rattus norvegicus 88-92 30737648-5 2019 In H9c2 rat cardiomyoblasts cultured with serum-free medium, GD significantly augmented eEF2 phosphorylation and signals related to autophagy [increase of microtubule-associated protein 1 light chain 3 (LC3)-II to LC3-I ratio] and apoptosis (cleavage of caspase-3) as determined by Western blotting. Gadolinium 61-63 caspase 3 Rattus norvegicus 254-263 30737648-6 2019 GD induced cell death, which was augmented by eEF2K gene knockdown using a small interfering RNA. Gadolinium 0-2 eukaryotic elongation factor-2 kinase Rattus norvegicus 46-51 30737648-8 2019 In contrast, eEF2K gene knockdown significantly inhibited GD-induced increase of LC3-II to LC3-I ratio and autophagosome formation as determined by an immunofluorescence staining. Gadolinium 58-60 eukaryotic elongation factor-2 kinase Rattus norvegicus 13-18 30737648-9 2019 An inhibitor of autophagy, 3-methyladenine or bafilomycin A1 significantly augmented GD-induced cleavage of caspase-3. Gadolinium 85-87 caspase 3 Rattus norvegicus 108-117 30737648-10 2019 Further, eEF2K gene knockdown significantly inhibited GD-induced phosphorylation of adenosine monophosphate-activated protein kinase (AMPK)alpha and its downstream substrate, unc-51 like autophagy activating kinase (ULK)1. Gadolinium 54-56 eukaryotic elongation factor-2 kinase Rattus norvegicus 9-14 30737648-10 2019 Further, eEF2K gene knockdown significantly inhibited GD-induced phosphorylation of adenosine monophosphate-activated protein kinase (AMPK)alpha and its downstream substrate, unc-51 like autophagy activating kinase (ULK)1. Gadolinium 54-56 unc-51 like autophagy activating kinase 1 Rattus norvegicus 175-221 30776218-0 2019 A Gadolinium Spin Label with Both a Narrow Central Transition and Short Tether for Use in Double Electron Electron Resonance Distance Measurements. Gadolinium 2-12 spindlin 1 Homo sapiens 13-17 30292747-8 2019 KM estimates of 2-year MFD-free survival for patients with gadolinium-enhanced lesions (GdE+) were 29% (95% CI, 11.7% to 48.2%) for untreated patients (n = 21). Gadolinium 59-69 amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase Homo sapiens 88-91 30552899-4 2019 We show that addition of the ROCE/SOCE and transient receptor potential channel (TRPC) blocker gadolinium (Gd3+, 300 muM) slows PIP2 depletion following 1 and 20 nsEP exposures. Gadolinium 95-105 latexin Homo sapiens 117-120 30786899-9 2019 Moreover, patients presenting at least one gadolinium-enhanced CNS lesion at baseline (n = 7) displayed significantly increased serum TWEAK levels in comparison with patients without any gadolinium-enhanced lesion at baseline (n = 21) (respectively 1421 +- 657 pg/mL vs 975 +- 382 pg/mL; p = 0.02). Gadolinium 43-53 TNF superfamily member 12 Homo sapiens 134-139 30635483-5 2019 Serum NfL (median 22.0, interquartile range 11.6-40.4 pg/mL) was noticeably increased in patients with a recent relapse, with a high number of T2 and gadolinium-enhancing lesions at baseline MRI. Gadolinium 150-160 neurofilament light chain Homo sapiens 6-9 30804672-0 2019 Gadolinium-doped bioglass scaffolds promote osteogenic differentiation of hBMSC via the Akt/GSK3beta pathway and facilitate bone repair in vivo. Gadolinium 0-10 AKT serine/threonine kinase 1 Rattus norvegicus 88-91 30804672-0 2019 Gadolinium-doped bioglass scaffolds promote osteogenic differentiation of hBMSC via the Akt/GSK3beta pathway and facilitate bone repair in vivo. Gadolinium 0-10 glycogen synthase kinase 3 beta Rattus norvegicus 92-100 30655255-2 2019 This prospective, multicenter study aimed to determine DSC feasibility and quality in children using custom administration of a standard dose of gadolinium. Gadolinium 145-155 desmocollin 3 Homo sapiens 55-58 30209850-10 2019 RESULTS: Gadolinium increased serum urea, Ca+2 , and Caspase-3 positive tubular cell number. Gadolinium 9-19 carbonic anhydrase 2 Rattus norvegicus 42-46 30209850-10 2019 RESULTS: Gadolinium increased serum urea, Ca+2 , and Caspase-3 positive tubular cell number. Gadolinium 9-19 caspase 3 Rattus norvegicus 53-62 29697952-2 2019 In this work, graphdiyne (GD) was first introduced to the visible-light catalytic system for hydrogen production, in which a CdS/GD heterojunction was prepared through a simple in situ growth process by adding Cd(AcO)2 into a dimethyl sulfoxide (DMSO) solution containing GD substrate. Gadolinium 26-28 CDP-diacylglycerol synthase 1 Homo sapiens 125-128 30704100-1 2019 Chemokines (C-X-C) motif ligand (CXCL) 5 and 8 are overexpressed in patients with multiple sclerosis, where CXCL5 serum levels were shown to correlate with blood-brain barrier dysfunction as evidenced by gadolinium-enhanced magnetic resonance imaging. Gadolinium 204-214 C-X-C motif chemokine ligand 5 Homo sapiens 12-40 30704100-1 2019 Chemokines (C-X-C) motif ligand (CXCL) 5 and 8 are overexpressed in patients with multiple sclerosis, where CXCL5 serum levels were shown to correlate with blood-brain barrier dysfunction as evidenced by gadolinium-enhanced magnetic resonance imaging. Gadolinium 204-214 C-X-C motif chemokine ligand 5 Homo sapiens 108-113 29697952-3 2019 The as-prepared CdS/GD heterojunction exhibits much higher performance for photocatalytic hydrogen evolution compared to that of pristine GD and CdS nanoparticles. Gadolinium 20-22 CDP-diacylglycerol synthase 1 Homo sapiens 16-19 29697952-4 2019 The photocatalytic performance of CdS/GD heterostructure containing 2.5 wt % of GD (GD2.5) is 2.6 times higher than that of the pristine CdS nanoparticles. Gadolinium 38-40 CDP-diacylglycerol synthase 1 Homo sapiens 34-37 29697952-4 2019 The photocatalytic performance of CdS/GD heterostructure containing 2.5 wt % of GD (GD2.5) is 2.6 times higher than that of the pristine CdS nanoparticles. Gadolinium 38-40 CDP-diacylglycerol synthase 1 Homo sapiens 137-140 29697952-5 2019 The enhanced catalytic performance can be ascribed to the formation of CdS/GD heterojunction, in which the presence of GD can not only stabilize CdS nanoparticles by preventing the agglomeration of CdS nanoparticles but also act as a photogenerated hole transfer material for efficiently separating photogenerated electron-hole pairs in CdS. Gadolinium 75-77 CDP-diacylglycerol synthase 1 Homo sapiens 71-74 29697952-5 2019 The enhanced catalytic performance can be ascribed to the formation of CdS/GD heterojunction, in which the presence of GD can not only stabilize CdS nanoparticles by preventing the agglomeration of CdS nanoparticles but also act as a photogenerated hole transfer material for efficiently separating photogenerated electron-hole pairs in CdS. Gadolinium 75-77 CDP-diacylglycerol synthase 1 Homo sapiens 145-148 29697952-5 2019 The enhanced catalytic performance can be ascribed to the formation of CdS/GD heterojunction, in which the presence of GD can not only stabilize CdS nanoparticles by preventing the agglomeration of CdS nanoparticles but also act as a photogenerated hole transfer material for efficiently separating photogenerated electron-hole pairs in CdS. Gadolinium 75-77 CDP-diacylglycerol synthase 1 Homo sapiens 145-148 29697952-5 2019 The enhanced catalytic performance can be ascribed to the formation of CdS/GD heterojunction, in which the presence of GD can not only stabilize CdS nanoparticles by preventing the agglomeration of CdS nanoparticles but also act as a photogenerated hole transfer material for efficiently separating photogenerated electron-hole pairs in CdS. Gadolinium 75-77 CDP-diacylglycerol synthase 1 Homo sapiens 145-148 29697952-5 2019 The enhanced catalytic performance can be ascribed to the formation of CdS/GD heterojunction, in which the presence of GD can not only stabilize CdS nanoparticles by preventing the agglomeration of CdS nanoparticles but also act as a photogenerated hole transfer material for efficiently separating photogenerated electron-hole pairs in CdS. Gadolinium 119-121 CDP-diacylglycerol synthase 1 Homo sapiens 71-74 29697952-5 2019 The enhanced catalytic performance can be ascribed to the formation of CdS/GD heterojunction, in which the presence of GD can not only stabilize CdS nanoparticles by preventing the agglomeration of CdS nanoparticles but also act as a photogenerated hole transfer material for efficiently separating photogenerated electron-hole pairs in CdS. Gadolinium 119-121 CDP-diacylglycerol synthase 1 Homo sapiens 145-148 29697952-5 2019 The enhanced catalytic performance can be ascribed to the formation of CdS/GD heterojunction, in which the presence of GD can not only stabilize CdS nanoparticles by preventing the agglomeration of CdS nanoparticles but also act as a photogenerated hole transfer material for efficiently separating photogenerated electron-hole pairs in CdS. Gadolinium 119-121 CDP-diacylglycerol synthase 1 Homo sapiens 145-148 29697952-5 2019 The enhanced catalytic performance can be ascribed to the formation of CdS/GD heterojunction, in which the presence of GD can not only stabilize CdS nanoparticles by preventing the agglomeration of CdS nanoparticles but also act as a photogenerated hole transfer material for efficiently separating photogenerated electron-hole pairs in CdS. Gadolinium 119-121 CDP-diacylglycerol synthase 1 Homo sapiens 145-148 32864561-12 2019 When higher signal is visible more than 36 hours after gadolinium-based contrast material administration it is associated with decreased eGFR. Gadolinium 55-65 epidermal growth factor receptor Homo sapiens 137-141 32864561-10 2019 When visible more than 36 hours after gadolinium-based contrast material administration, such increased signal is associated with decreased eGFR. Gadolinium 38-48 epidermal growth factor receptor Homo sapiens 140-144 29697952-2 2019 In this work, graphdiyne (GD) was first introduced to the visible-light catalytic system for hydrogen production, in which a CdS/GD heterojunction was prepared through a simple in situ growth process by adding Cd(AcO)2 into a dimethyl sulfoxide (DMSO) solution containing GD substrate. Gadolinium 26-28 aconitase 2 Homo sapiens 213-218 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 57-59 immunoglobulin heavy constant alpha 1 Homo sapiens 60-64 31279989-1 2019 BACKGROUND: Dynamic contrast enhanced (DCE) breast MRI is highly sensitive for breast cancer and requires gadolinium-based contrast agents (GBCA)s, which have potential safety concerns. Gadolinium 106-116 24-dehydrocholesterol reductase Homo sapiens 39-42 31702485-2 2019 Either in elemental form or nanoparticulate form, gadolinium toxicity is believed to occur due to the deposition of gadolinium ion (designated as Gd3+ ion or simply G ion). Gadolinium 50-60 GRDX Homo sapiens 146-149 31702485-2 2019 Either in elemental form or nanoparticulate form, gadolinium toxicity is believed to occur due to the deposition of gadolinium ion (designated as Gd3+ ion or simply G ion). Gadolinium 116-126 GRDX Homo sapiens 146-149 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 57-59 immunoglobulin heavy constant alpha 1 Homo sapiens 41-45 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 57-59 IGAN1 Homo sapiens 159-163 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 57-59 immunoglobulin heavy constant alpha 1 Homo sapiens 60-64 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 57-59 IGAN1 Homo sapiens 115-119 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 148-150 immunoglobulin heavy constant alpha 1 Homo sapiens 41-45 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 148-150 immunoglobulin heavy constant alpha 1 Homo sapiens 60-64 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 148-150 IGAN1 Homo sapiens 115-119 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 148-150 immunoglobulin heavy constant alpha 1 Homo sapiens 60-64 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 148-150 IGAN1 Homo sapiens 159-163 31574506-2 2019 A monoclonal antibody, KM55, which specifically recognizes Gd-IgA1 has been developed. Gadolinium 59-61 immunoglobulin heavy constant alpha 1 Homo sapiens 62-66 31574506-3 2019 In the present study, we further explored the clinical significance of Gd-IgA1 using KM55. Gadolinium 71-73 immunoglobulin heavy constant alpha 1 Homo sapiens 74-78 31574506-4 2019 METHODS: In this study, we enrolled 75 patients with IgAN and 80 healthy controls and detected the plasma Gd-IgA1 levels using the KM55 ELISA method. Gadolinium 106-108 immunoglobulin heavy constant alpha 1 Homo sapiens 109-113 31574506-5 2019 We also stained -mesangial Gd-IgA1 deposition using KM55. Gadolinium 27-29 immunoglobulin heavy constant alpha 1 Homo sapiens 30-34 31574506-6 2019 RESULTS: We observed that the levels of plasma Gd-IgA1 in IgAN patients were elevated compared to the corresponding levels of healthy controls. Gadolinium 47-49 immunoglobulin heavy constant alpha 1 Homo sapiens 50-54 31574506-6 2019 RESULTS: We observed that the levels of plasma Gd-IgA1 in IgAN patients were elevated compared to the corresponding levels of healthy controls. Gadolinium 47-49 IGAN1 Homo sapiens 58-62 31574506-7 2019 Patients were divided into 2 groups based on the median of Gd-IgA1. Gadolinium 59-61 immunoglobulin heavy constant alpha 1 Homo sapiens 62-66 31574506-8 2019 Patients with high Gd-IgA1 levels had significantly higher levels of uric acid (UA) and IgA. Gadolinium 19-21 immunoglobulin heavy constant alpha 1 Homo sapiens 22-26 31574506-10 2019 In addition, positive correlations were observed between Gd-IgA1 and Bb, C3a, C4d and MAC. Gadolinium 57-59 immunoglobulin heavy constant alpha 1 Homo sapiens 60-64 31574506-11 2019 Mesangial Gd-IgA1 was positive in IgAN but negative in the normal renal tissue adjacent to neoplasm. Gadolinium 10-12 immunoglobulin heavy constant alpha 1 Homo sapiens 13-17 31574506-11 2019 Mesangial Gd-IgA1 was positive in IgAN but negative in the normal renal tissue adjacent to neoplasm. Gadolinium 10-12 IGAN1 Homo sapiens 34-38 31574506-12 2019 We next analyzed the correlation between plasma Gd-IgA1 and mesangial Gd-IgA1 deposition. Gadolinium 48-50 immunoglobulin heavy constant alpha 1 Homo sapiens 51-55 31574506-12 2019 We next analyzed the correlation between plasma Gd-IgA1 and mesangial Gd-IgA1 deposition. Gadolinium 48-50 immunoglobulin heavy constant alpha 1 Homo sapiens 73-77 31574506-12 2019 We next analyzed the correlation between plasma Gd-IgA1 and mesangial Gd-IgA1 deposition. Gadolinium 70-72 immunoglobulin heavy constant alpha 1 Homo sapiens 51-55 31574506-12 2019 We next analyzed the correlation between plasma Gd-IgA1 and mesangial Gd-IgA1 deposition. Gadolinium 70-72 immunoglobulin heavy constant alpha 1 Homo sapiens 73-77 31574506-13 2019 The results showed that a high level of plasma Gd-IgA1 was related to the deposition of mesangial Gd-IgA1, although the difference was not significant. Gadolinium 47-49 immunoglobulin heavy constant alpha 1 Homo sapiens 50-54 31574506-13 2019 The results showed that a high level of plasma Gd-IgA1 was related to the deposition of mesangial Gd-IgA1, although the difference was not significant. Gadolinium 47-49 immunoglobulin heavy constant alpha 1 Homo sapiens 101-105 31574506-13 2019 The results showed that a high level of plasma Gd-IgA1 was related to the deposition of mesangial Gd-IgA1, although the difference was not significant. Gadolinium 98-100 immunoglobulin heavy constant alpha 1 Homo sapiens 50-54 31574506-13 2019 The results showed that a high level of plasma Gd-IgA1 was related to the deposition of mesangial Gd-IgA1, although the difference was not significant. Gadolinium 98-100 immunoglobulin heavy constant alpha 1 Homo sapiens 101-105 31574506-14 2019 CONCLUSION: We verified the elevated level of plasma and -mesangial Gd-IgA1 in patients with IgAN by KM55, which provided an alternative, easy, and reliable tool for diagnosis and activity assessment of IgAN. Gadolinium 68-70 immunoglobulin heavy constant alpha 1 Homo sapiens 71-75 31574506-14 2019 CONCLUSION: We verified the elevated level of plasma and -mesangial Gd-IgA1 in patients with IgAN by KM55, which provided an alternative, easy, and reliable tool for diagnosis and activity assessment of IgAN. Gadolinium 68-70 IGAN1 Homo sapiens 93-97 31574506-14 2019 CONCLUSION: We verified the elevated level of plasma and -mesangial Gd-IgA1 in patients with IgAN by KM55, which provided an alternative, easy, and reliable tool for diagnosis and activity assessment of IgAN. Gadolinium 68-70 IGAN1 Homo sapiens 203-207 31574506-15 2019 The level of plasma Gd-IgA1 positively correlated with levels of UA, total IgA levels, and complement activation products. Gadolinium 20-22 immunoglobulin heavy constant alpha 1 Homo sapiens 23-27 30368799-4 2018 We present a comprehensive characterization of the seizurogenic, epileptogenic, and neuropathologic effects of GD exposure with delayed anticonvulsant treatment in the plasma carboxylesterase knockout (ES1-/-) mouse. Gadolinium 111-113 glutamine amidotransferase like class 1 domain containing 3A Mus musculus 202-205 30368799-12 2018 We present evidence that argues for the use of the ES1-/- mouse model to screen anticonvulsant, antiepileptic, and/or neuroprotective drugs against GD-induced toxicity, as well as to identify mechanisms of GD-induced epileptogenesis. Gadolinium 148-150 glutamine amidotransferase like class 1 domain containing 3A Mus musculus 51-54 30515070-0 2018 Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/64Cu PET Imaging. Gadolinium 21-31 thyroid stimulating hormone receptor Mus musculus 112-115 30498433-10 2018 In contrast, the presence of lesions in the brain and spine on gadolinium-enhanced MRI was associated with an increase in the numbers of CCR3+/CCR5+ (subset of CD8 memory T cells), CD4+/CCR3+ (Th2 cells), and CD4+/CCR5+ (Th1 cells) CSF-EVs. Gadolinium 63-73 C-C motif chemokine receptor 3 Homo sapiens 137-141 30498433-10 2018 In contrast, the presence of lesions in the brain and spine on gadolinium-enhanced MRI was associated with an increase in the numbers of CCR3+/CCR5+ (subset of CD8 memory T cells), CD4+/CCR3+ (Th2 cells), and CD4+/CCR5+ (Th1 cells) CSF-EVs. Gadolinium 63-73 C-C motif chemokine receptor 5 Homo sapiens 143-147 30498433-10 2018 In contrast, the presence of lesions in the brain and spine on gadolinium-enhanced MRI was associated with an increase in the numbers of CCR3+/CCR5+ (subset of CD8 memory T cells), CD4+/CCR3+ (Th2 cells), and CD4+/CCR5+ (Th1 cells) CSF-EVs. Gadolinium 63-73 CD8a molecule Homo sapiens 160-163 30498433-10 2018 In contrast, the presence of lesions in the brain and spine on gadolinium-enhanced MRI was associated with an increase in the numbers of CCR3+/CCR5+ (subset of CD8 memory T cells), CD4+/CCR3+ (Th2 cells), and CD4+/CCR5+ (Th1 cells) CSF-EVs. Gadolinium 63-73 CD4 molecule Homo sapiens 181-184 30498433-10 2018 In contrast, the presence of lesions in the brain and spine on gadolinium-enhanced MRI was associated with an increase in the numbers of CCR3+/CCR5+ (subset of CD8 memory T cells), CD4+/CCR3+ (Th2 cells), and CD4+/CCR5+ (Th1 cells) CSF-EVs. Gadolinium 63-73 C-C motif chemokine receptor 3 Homo sapiens 186-190 30498433-10 2018 In contrast, the presence of lesions in the brain and spine on gadolinium-enhanced MRI was associated with an increase in the numbers of CCR3+/CCR5+ (subset of CD8 memory T cells), CD4+/CCR3+ (Th2 cells), and CD4+/CCR5+ (Th1 cells) CSF-EVs. Gadolinium 63-73 CD4 molecule Homo sapiens 209-212 30498433-10 2018 In contrast, the presence of lesions in the brain and spine on gadolinium-enhanced MRI was associated with an increase in the numbers of CCR3+/CCR5+ (subset of CD8 memory T cells), CD4+/CCR3+ (Th2 cells), and CD4+/CCR5+ (Th1 cells) CSF-EVs. Gadolinium 63-73 C-C motif chemokine receptor 5 Homo sapiens 214-218 30571380-7 2018 Patients with late gadolinium enhancement on cardiac magnetic resonance imaging had greater levels of BNP , MR -pro ANP , TNFR 1, TNFR 2, and MMP -2. Gadolinium 19-29 natriuretic peptide B Homo sapiens 102-105 30571380-7 2018 Patients with late gadolinium enhancement on cardiac magnetic resonance imaging had greater levels of BNP , MR -pro ANP , TNFR 1, TNFR 2, and MMP -2. Gadolinium 19-29 natriuretic peptide A Homo sapiens 116-119 30571380-7 2018 Patients with late gadolinium enhancement on cardiac magnetic resonance imaging had greater levels of BNP , MR -pro ANP , TNFR 1, TNFR 2, and MMP -2. Gadolinium 19-29 TNF receptor superfamily member 1A Homo sapiens 122-128 30571380-7 2018 Patients with late gadolinium enhancement on cardiac magnetic resonance imaging had greater levels of BNP , MR -pro ANP , TNFR 1, TNFR 2, and MMP -2. Gadolinium 19-29 TNF receptor superfamily member 1B Homo sapiens 130-136 30571380-7 2018 Patients with late gadolinium enhancement on cardiac magnetic resonance imaging had greater levels of BNP , MR -pro ANP , TNFR 1, TNFR 2, and MMP -2. Gadolinium 19-29 matrix metallopeptidase 2 Homo sapiens 142-148 30204075-0 2018 Gadolinium Retention: A Research Roadmap from the 2018 NIH/ACR/RSNA Workshop on Gadolinium Chelates. Gadolinium 0-10 acrosin Homo sapiens 59-62 30347750-5 2018 Based on our previous experience, by using gadolinium-enriched paramagnetic fluorescence micellar nanoparticles conjugated with AP9 (NAP9), an EMMPRIN-specific binding peptide, magnetic resonance sequences allowed non-invasive visualization of carotid EMMPRIN in NOS3/apoE over apoE control mice, in which atheroma plaques were significantly reduced. Gadolinium 43-53 basigin Mus musculus 143-150 31458078-6 2018 The estimated interaction energy (DeltaG binding) between Gd@C60 and lysozyme is -18.7 kcal mol-1, suggesting the possibility of using proteins as supramolecular carriers for EMFs. Gadolinium 58-60 lysozyme Homo sapiens 69-77 31458078-7 2018 pi-pi stacking, hydrophobic interactions, surfactant-like interactions, and electrostatic interactions govern the formation of the hybrid between Gd@C60 and lysozyme. Gadolinium 146-148 lysozyme Homo sapiens 157-165 31458078-8 2018 The comparison of the energy contributions to the binding between C60 or Gd@C60 and lysozyme suggests that, although shape complementarity remains the driving force of the binding, the presence of electron transfer from the gadolinium atom to the carbon cage induces a charge distribution on the fullerene cage that strongly affects its interaction with the protein. Gadolinium 224-234 lysozyme Homo sapiens 84-92 30347750-5 2018 Based on our previous experience, by using gadolinium-enriched paramagnetic fluorescence micellar nanoparticles conjugated with AP9 (NAP9), an EMMPRIN-specific binding peptide, magnetic resonance sequences allowed non-invasive visualization of carotid EMMPRIN in NOS3/apoE over apoE control mice, in which atheroma plaques were significantly reduced. Gadolinium 43-53 basigin Mus musculus 252-259 30347750-5 2018 Based on our previous experience, by using gadolinium-enriched paramagnetic fluorescence micellar nanoparticles conjugated with AP9 (NAP9), an EMMPRIN-specific binding peptide, magnetic resonance sequences allowed non-invasive visualization of carotid EMMPRIN in NOS3/apoE over apoE control mice, in which atheroma plaques were significantly reduced. Gadolinium 43-53 nitric oxide synthase 3, endothelial cell Mus musculus 263-267 30347750-5 2018 Based on our previous experience, by using gadolinium-enriched paramagnetic fluorescence micellar nanoparticles conjugated with AP9 (NAP9), an EMMPRIN-specific binding peptide, magnetic resonance sequences allowed non-invasive visualization of carotid EMMPRIN in NOS3/apoE over apoE control mice, in which atheroma plaques were significantly reduced. Gadolinium 43-53 apolipoprotein E Mus musculus 268-272 30347750-5 2018 Based on our previous experience, by using gadolinium-enriched paramagnetic fluorescence micellar nanoparticles conjugated with AP9 (NAP9), an EMMPRIN-specific binding peptide, magnetic resonance sequences allowed non-invasive visualization of carotid EMMPRIN in NOS3/apoE over apoE control mice, in which atheroma plaques were significantly reduced. Gadolinium 43-53 apolipoprotein E Mus musculus 278-282 29737435-0 2018 Anti-EpCAM scFv gadolinium chelate: a novel targeted MRI contrast agent for imaging of colorectal cancer. Gadolinium 16-26 epithelial cell adhesion molecule Homo sapiens 5-10 29737435-0 2018 Anti-EpCAM scFv gadolinium chelate: a novel targeted MRI contrast agent for imaging of colorectal cancer. Gadolinium 16-26 immunglobulin heavy chain variable region Homo sapiens 11-15 29737435-2 2018 In the present study, a novel contrast agent was developed by conjugating anti-EpCAM humanized scFv with gadolinium chelate to achieve target specificity. Gadolinium 105-115 epithelial cell adhesion molecule Homo sapiens 79-84 29737435-4 2018 The scFv monomer was linked to maleimide-DTPA via unpaired cysteine at the scFv C-terminus, followed by chelation with gadolinium (Gd). Gadolinium 119-129 immunglobulin heavy chain variable region Homo sapiens 4-8 29737435-4 2018 The scFv monomer was linked to maleimide-DTPA via unpaired cysteine at the scFv C-terminus, followed by chelation with gadolinium (Gd). Gadolinium 131-133 immunglobulin heavy chain variable region Homo sapiens 4-8 29848886-6 2018 The frequency of the CC genotype in the TARC rs223828 SNP was higher in patients with intractable GD than in patients with GD in remission. Gadolinium 98-100 C-C motif chemokine ligand 17 Homo sapiens 40-44 29667086-9 2018 Regarding the molecular subgroups, gadolinium enhancement is an unfavorable prognostic factor in gliomas with IDHwild-type and those with ATRX retention. Gadolinium 35-45 ATRX chromatin remodeler Homo sapiens 138-142 29572636-12 2018 KEY POINTS: Diffusion-weighted MRI aids the identification of non-gadolinium-enhancing malignant gliomas ADC measurements may permit non-gadolinium-enhancing glioma molecular subtyping IDH wild-type gliomas have lower ADC values than IDH-mutant tumours Single cross-section and volumetric ADC measurements yielded comparable results in this study. Gadolinium 68-78 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 191-194 29970480-9 2018 Although both GBM108-vector and GBM108-VEGFA readily imaged on MRI following gadolinium contrast administration, GBM108-VEGFA tumors had a significantly enhanced drug and gadolinium accumulation, as determined by MALDI-MSI. Gadolinium 171-181 vascular endothelial growth factor A Homo sapiens 120-125 29848886-6 2018 The frequency of the CC genotype in the TARC rs223828 SNP was higher in patients with intractable GD than in patients with GD in remission. Gadolinium 123-125 C-C motif chemokine ligand 17 Homo sapiens 40-44 30094057-7 2018 CSF GAP-43 concentrations correlated with CSF mononuclear cell counts (p = 0.031) and were inversely correlated with patient age (p = 0.038) with a trend for higher CSF GAP-43 concentrations in patients with gadolinium-enhancing MRI lesions and positive CSF oligoclonal immunoglobulin G status. Gadolinium 208-218 growth associated protein 43 Homo sapiens 4-10 30094057-7 2018 CSF GAP-43 concentrations correlated with CSF mononuclear cell counts (p = 0.031) and were inversely correlated with patient age (p = 0.038) with a trend for higher CSF GAP-43 concentrations in patients with gadolinium-enhancing MRI lesions and positive CSF oligoclonal immunoglobulin G status. Gadolinium 208-218 growth associated protein 43 Homo sapiens 169-175 29735362-2 2018 In this study, we tested whether an albumin-binding intravascular contrast agent (gadofosveset) allows for improved quantification of myocardial permeability compared to the conventional extracellular contrast agent Gd-DTPA using late gadolinium enhancement (LGE) and T1 mapping in vivo. Gadolinium 235-245 albumin Mus musculus 36-43 29230554-0 2018 Correction to: Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful? Gadolinium 136-146 heme binding protein 1 Homo sapiens 114-117 29989405-3 2018 The positive tumor-targeting ability of pEGFR-targeted Ba2GdF7 NPs is achieved by conjugation of EGFR-targeted peptides on the 6.5 nm Ba2GdF7 NP surface through the formation of Gd-phosphonate coordinate bonds. Gadolinium 58-60 epidermal growth factor receptor Homo sapiens 41-45 30214669-2 2018 We developed gadolinium-labeled tropoelastin-specific magnetic resonance contrast agents (Gd-TESMAs) for tropoelastin imaging in animal models. Gadolinium 13-23 elastin Mus musculus 32-44 30214669-2 2018 We developed gadolinium-labeled tropoelastin-specific magnetic resonance contrast agents (Gd-TESMAs) for tropoelastin imaging in animal models. Gadolinium 13-23 elastin Mus musculus 105-117 30045399-7 2018 RESULTS: In dCT (transverse 4D-MRA) hGb showed 39.0 % (14.5 %) lower arterial peak gadolinium concentrations (peak SIs) and 20.6 % (33.8 %) shorter FWHM compared to sGb. Gadolinium 83-93 cytoglobin Homo sapiens 36-39 29196542-6 2018 In those with late gadolinium enhancement (LGE) indicative of myocardial fibrosis, cMyC concentrations were higher (32 (21-56) ng/L vs 17 (12-24) ng/L without LGE, P<0.001). Gadolinium 19-29 MYC proto-oncogene, bHLH transcription factor Homo sapiens 83-87 29687748-9 2018 Prototype chokes with gadolinium solution cores exhibited increasing magnetic susceptibility, and insertion loss (S21) also showed higher attenuation as gadolinium concentration increased. Gadolinium 153-163 ribosomal protein S21 Homo sapiens 114-117 29709797-2 2018 When linear dorsal subpial enhancement is accompanied by central cord/canal enhancement the axial post-gadolinium sequences may reveal a "trident" pattern that has previously been shown to be strongly suggestive of spinal cord sarcoidosis. Gadolinium 103-113 forkhead box M1 Homo sapiens 138-145 29898838-13 2018 Late gadolinium enhancement (+-SD) at 2 months was lower in 15 ng IGF1 (34.5 +- 29.6 g) compared to placebo (49.1 +- 19.3 g) or 1.5 ng IGF1 (47.4 +- 22.4 g) treated patients, although the result was not statistically significant (P = .095). Gadolinium 5-15 insulin like growth factor 1 Homo sapiens 66-70 29784058-0 2018 Fat-suppressed gadolinium-enhanced isotropic high-resolution 3D-GRE-T1WI for predicting small node metastases in patients with rectal cancer. Gadolinium 15-25 FAT atypical cadherin 1 Homo sapiens 0-3 29349673-8 2018 Pannexin1 or connexin blockers and gadolinium, a Piezo1 blocker, reduced the mechanically induced ATP release without altering spontaneous nucleotide levels. Gadolinium 35-45 piezo-type mechanosensitive ion channel component 1 Rattus norvegicus 49-55 29784058-1 2018 BACKGROUND: To investigate the application value of fat-suppressed gadolinium-enhanced isotropic high-resolution 3D-GRE-T1WI in regional nodes with different short-axis diameter ranges in rectal cancer, especially in nodes <=5 mm. Gadolinium 67-77 FAT atypical cadherin 1 Homo sapiens 52-55 29784058-13 2018 CONCLUSIONS: Enhancement characteristics based on fat-suppressed gadolinium-enhanced isotropic high-resolution 3D-GRE-T1WI were helpful for diagnosing metastatic nodes in rectal cancer and were a reliable indicator for nodes <=5 mm. Gadolinium 65-75 FAT atypical cadherin 1 Homo sapiens 50-53 29695578-0 2018 cDNA Microarray Analysis and Influx Transporter OATP1B1 in Liver Cells After Exposure to Gadoxetate Disodium, a Gadolinium-based Contrast Agent in MRI Liver Imaging. Gadolinium 112-122 solute carrier organic anion transporter family member 1B1 Homo sapiens 48-55 29555471-4 2018 After these steps, a monoclonal antibody (YPSMA-1) to prostate-specific membrane antigen (PSMA) was conjugated with carboxyl-modified Gd@SiO2 (Gd@SiO2-COOH) nanoparticles (NPs) by the carbodiimide method. Gadolinium 134-136 folate hydrolase 1 Homo sapiens 54-88 29555471-4 2018 After these steps, a monoclonal antibody (YPSMA-1) to prostate-specific membrane antigen (PSMA) was conjugated with carboxyl-modified Gd@SiO2 (Gd@SiO2-COOH) nanoparticles (NPs) by the carbodiimide method. Gadolinium 134-136 folate hydrolase 1 Homo sapiens 43-47 29555471-10 2018 These results suggest that the synthesized Gd@SiO2-Ab NPs have great potential as specific MR contrast agents for PSMA receptor-positive PCa cells. Gadolinium 43-45 folate hydrolase 1 Homo sapiens 114-118 29428723-6 2018 Additionally, the Piezo1 antagonists, gadolinium and ruthenium red, but not GsMTx4, effectively blocks Yoda1-induced Akt activation. Gadolinium 38-48 piezo type mechanosensitive ion channel component 1 Homo sapiens 18-24 29309992-0 2018 Gadolinium-chelate functionalized bismuth nanotheranostic agent for in vivo MRI/CT/PAI imaging-guided photothermal cancer therapy. Gadolinium 0-10 serpin family E member 1 Homo sapiens 83-86 29309992-4 2018 In vitro and in vivo study demonstrated that Gd-PEG-Bi NPs have ultrahigh X-ray attenuation coefficient, short T1 relaxation time in MRI, and strong PAI signal. Gadolinium 45-47 serpin family E member 1 Homo sapiens 149-152 29399370-8 2018 An excellent linear agreement (R2>0.998) was observed between measured relaxation rates (R1/R2) and gadolinium concentration. Gadolinium 103-113 CD1b molecule Homo sapiens 92-97 29263255-1 2018 Insertion of a single-chain variable-fragment antibody (scFv) to HER2 (human epidermal growth factor receptor 2) in gD, gH, or gB gives rise to herpes simplex viruses (HSVs) specifically retargeted to HER2-positive cancer cells, hence to highly specific nonattenuated oncolytic agents. Gadolinium 116-118 immunglobulin heavy chain variable region Homo sapiens 56-60 29263255-1 2018 Insertion of a single-chain variable-fragment antibody (scFv) to HER2 (human epidermal growth factor receptor 2) in gD, gH, or gB gives rise to herpes simplex viruses (HSVs) specifically retargeted to HER2-positive cancer cells, hence to highly specific nonattenuated oncolytic agents. Gadolinium 116-118 erb-b2 receptor tyrosine kinase 2 Homo sapiens 65-69 29263255-1 2018 Insertion of a single-chain variable-fragment antibody (scFv) to HER2 (human epidermal growth factor receptor 2) in gD, gH, or gB gives rise to herpes simplex viruses (HSVs) specifically retargeted to HER2-positive cancer cells, hence to highly specific nonattenuated oncolytic agents. Gadolinium 116-118 erb-b2 receptor tyrosine kinase 2 Homo sapiens 77-111 29865247-3 2018 This work reports the synthesis of a known osteoprotegerin peptide analogue, YCEIEFCYLIR (OP3-4), and its tagging with a gadolinium chelate, a standard contrast agent for magnetic resonance imaging. Gadolinium 121-131 TNF receptor superfamily member 11b Homo sapiens 43-58 29425846-5 2018 Here, we report on a human endogenous protein, glutathione S-transferase (GST), with favorable amino acid motifs, that has innate talents in incubating high quality gold nanoparticles without adding reducing agents at physiological temperature, and particularly can further anchor gadolinium ions without adding extra chelators. Gadolinium 281-291 glutathione S-transferase kappa 1 Homo sapiens 47-72 29425846-5 2018 Here, we report on a human endogenous protein, glutathione S-transferase (GST), with favorable amino acid motifs, that has innate talents in incubating high quality gold nanoparticles without adding reducing agents at physiological temperature, and particularly can further anchor gadolinium ions without adding extra chelators. Gadolinium 281-291 glutathione S-transferase kappa 1 Homo sapiens 74-77 29528358-0 2018 Charging nanoparticles: increased binding of Gd@C82(OH)22 derivatives to human MMP-9. Gadolinium 45-47 matrix metallopeptidase 9 Homo sapiens 79-84 29528358-7 2018 Compared with Gd@C82(OH)22, Gd@C82(OH)21(PO4)2- binds at least 1.5 to 2.5 kcal mol-1 more strongly to MMP-9. Gadolinium 14-16 matrix metallopeptidase 9 Homo sapiens 102-107 29528358-7 2018 Compared with Gd@C82(OH)22, Gd@C82(OH)21(PO4)2- binds at least 1.5 to 2.5 kcal mol-1 more strongly to MMP-9. Gadolinium 28-30 matrix metallopeptidase 9 Homo sapiens 102-107 29428723-6 2018 Additionally, the Piezo1 antagonists, gadolinium and ruthenium red, but not GsMTx4, effectively blocks Yoda1-induced Akt activation. Gadolinium 38-48 AKT serine/threonine kinase 1 Homo sapiens 117-120 29946640-5 2018 RESULTS: The concentration of IL-6 and TNF-alpha in serum and GCF of patients with GD+CP group was significantly higher than that in CP group and GD group (P<0.05). Gadolinium 83-85 interleukin 6 Homo sapiens 30-34 29279295-11 2018 CONCLUSION: Recent changes to screening guidelines for group II gadolinium-based contrast agents by the ACR will likely have major financial implications. Gadolinium 64-74 acrosin Homo sapiens 104-107 29946640-5 2018 RESULTS: The concentration of IL-6 and TNF-alpha in serum and GCF of patients with GD+CP group was significantly higher than that in CP group and GD group (P<0.05). Gadolinium 83-85 tumor necrosis factor Homo sapiens 39-48 29946640-5 2018 RESULTS: The concentration of IL-6 and TNF-alpha in serum and GCF of patients with GD+CP group was significantly higher than that in CP group and GD group (P<0.05). Gadolinium 146-148 interleukin 6 Homo sapiens 30-34 29946640-5 2018 RESULTS: The concentration of IL-6 and TNF-alpha in serum and GCF of patients with GD+CP group was significantly higher than that in CP group and GD group (P<0.05). Gadolinium 146-148 tumor necrosis factor Homo sapiens 39-48 29946640-6 2018 The level of IL-6 and TNF-alpha in serum and GCF of patients in GD+CP group and GD group was positively correlated with FT3 and FT4 (P<0.05), and the correlation between GD+CP group was significantly higher than that in GD group. Gadolinium 64-66 interleukin 6 Homo sapiens 13-17 29946640-6 2018 The level of IL-6 and TNF-alpha in serum and GCF of patients in GD+CP group and GD group was positively correlated with FT3 and FT4 (P<0.05), and the correlation between GD+CP group was significantly higher than that in GD group. Gadolinium 64-66 tumor necrosis factor Homo sapiens 22-31 29946640-7 2018 CONCLUSIONS: The level of IL-6 and TNF-alpha in GD+CP group were significantly higher than those in CP group and GD group, indicating that there is an interaction between periodontitis and Graves" disease in immune mechanism. Gadolinium 48-50 interleukin 6 Homo sapiens 26-30 29946640-7 2018 CONCLUSIONS: The level of IL-6 and TNF-alpha in GD+CP group were significantly higher than those in CP group and GD group, indicating that there is an interaction between periodontitis and Graves" disease in immune mechanism. Gadolinium 48-50 tumor necrosis factor Homo sapiens 35-44 28822252-4 2018 The investigations revealed that use of mixed bed (MB) resin column consisting of Strong Acid Cation (SAC) resin and Strong Base Anion (SBA) resin followed by SAC resin column is efficient in removing the Gd3+ and NO3- from the system besides maintaining the pH of the moderator system in the desirable regime, where gadolinium does not get precipitated as its hydroxide. Gadolinium 317-327 NBL1, DAN family BMP antagonist Homo sapiens 214-217 29318240-2 2018 Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides. Gadolinium 148-158 matrix metallopeptidase 2 Homo sapiens 216-221 29318240-2 2018 Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides. Gadolinium 148-158 matrix metallopeptidase 2 Homo sapiens 216-219 29266945-0 2018 Activation of H2 by Gadolinium Cation (Gd+): Bond Energy of GdH+ and Mechanistic Insights from Guided Ion Beam and Theoretical Studies. Gadolinium 20-30 glutamate dehydrogenase 1 Homo sapiens 60-63 29281280-1 2018 Atomistic molecular dynamics (MD) simulations are performed in order to derive thermodynamic properties important to understand the extraction of gadolinium (Gd3+) and uranium dioxide (UO2) with dibenzo crown ether (DBCE) in nitrobenzene (NB) and octanol (OCT) solvents. Gadolinium 146-156 GRDX Homo sapiens 158-161 29309426-0 2018 Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker gammaH2AX. Gadolinium 0-10 tumor protein p53 binding protein 1 Homo sapiens 122-127 30021195-3 2018 In human myometrium, the Na+ leak channel, non-selective (NALCN) contributes to a gadolinium-sensitive, Na+-dependent leak current. Gadolinium 82-92 sodium leak channel, non-selective Homo sapiens 58-63 29291143-8 2018 POD activity was 8.1 times higher for GD as compared that that of FHIA-23. Gadolinium 38-40 peroxidase 24 Musa acuminata 0-3 29154535-0 2017 Novel Gd-Loaded Silicon Nanohybrid: A Potential Epidermal Growth Factor Receptor Expressing Cancer Cell Targeting Magnetic Resonance Imaging Contrast Agent. Gadolinium 6-8 epidermal growth factor receptor Homo sapiens 48-80 29115504-4 2018 A MAPK inhibitor and U0126, an ERK inhibitor, abolished the effects of GD on Cx43 expression levels. Gadolinium 71-73 Eph receptor B1 Rattus norvegicus 31-34 29115504-4 2018 A MAPK inhibitor and U0126, an ERK inhibitor, abolished the effects of GD on Cx43 expression levels. Gadolinium 71-73 gap junction protein, alpha 1 Rattus norvegicus 77-81 29154535-3 2017 The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on silicon nanostructures and conjugated to an antibody specific for epidermal growth factor receptor (EGFR) via a hydrazone linkage. Gadolinium 22-24 epidermal growth factor receptor Homo sapiens 133-165 29154535-3 2017 The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on silicon nanostructures and conjugated to an antibody specific for epidermal growth factor receptor (EGFR) via a hydrazone linkage. Gadolinium 22-24 epidermal growth factor receptor Homo sapiens 167-171 29154535-3 2017 The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on silicon nanostructures and conjugated to an antibody specific for epidermal growth factor receptor (EGFR) via a hydrazone linkage. Gadolinium 37-39 epidermal growth factor receptor Homo sapiens 133-165 29154535-3 2017 The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on silicon nanostructures and conjugated to an antibody specific for epidermal growth factor receptor (EGFR) via a hydrazone linkage. Gadolinium 37-39 epidermal growth factor receptor Homo sapiens 167-171 29276624-1 2017 Background: Evolution of gadolinium-enhancing lesions into chronic black holes (CBH) may be reduced by interferon (IFN) therapy. Gadolinium 25-35 interferon alpha 1 Homo sapiens 103-119 29209636-8 2018 NF-L levels were associated with the presence of T1 gadolinium-enhanced lesions up to 2 months before (p < 0.001) and 1 month after (p = 0.009) the time of biomarker measurement. Gadolinium 52-62 neurofilament light chain Homo sapiens 0-4 28866071-2 2017 The neuroinflammatory response is characterized by the upregulation of the pro-inflammatory cytokine, interleukin-1 (IL-1), which mediates the expression of other neurotoxic cytokines induced after GD exposure. Gadolinium 198-200 interleukin 1 complex Mus musculus 102-115 28866071-2 2017 The neuroinflammatory response is characterized by the upregulation of the pro-inflammatory cytokine, interleukin-1 (IL-1), which mediates the expression of other neurotoxic cytokines induced after GD exposure. Gadolinium 198-200 interleukin 1 complex Mus musculus 117-121 28866071-11 2017 Therefore, the IL-1 signaling pathway affects neurodegeneration and behavior after GD-induced convulsions. Gadolinium 83-85 interleukin 1 complex Mus musculus 15-19 28722357-2 2017 Herein, a heterogeneous core-shell-shell nanostructure of NaYbF4 :Gd/Tm@NaGdF4 @CaF2 :Ce is developed to realize efficient photon upconversion in Ce3+ ions through a Gd-mediated energy migration process. Gadolinium 66-68 CCR4-NOT transcription complex subunit 8 Homo sapiens 80-84 29087183-0 2017 BSA-Bioinspired Gadolinium Hybrid-Functionalized Hollow Gold Nanoshells for NIRF/PA/CT/MR Quadmodal Diagnostic Imaging-Guided Photothermal/Photodynamic Cancer Therapy. Gadolinium 16-26 interleukin 17B Homo sapiens 76-86 29087183-2 2017 In this research, we have constructed an innovative multifunctional drug delivery platform by gadolinium (Gd)-based bovine serum albumin (BSA) hybrid-coated hollow gold nanoshells (Au@BSA-Gd). Gadolinium 94-104 albumin Homo sapiens 123-136 29087183-2 2017 In this research, we have constructed an innovative multifunctional drug delivery platform by gadolinium (Gd)-based bovine serum albumin (BSA) hybrid-coated hollow gold nanoshells (Au@BSA-Gd). Gadolinium 106-108 albumin Homo sapiens 123-136 29067958-3 2017 METHODS: Metastasis-associated MR molecular imaging probe, integrin alphavbeta3ligand cRGD-PEG-DGL-DTPA-Gd (Gd-RGD), were constructed. Gadolinium 104-106 integrin subunit alpha V Homo sapiens 59-79 28815927-4 2017 The results demonstrate that Tf homodimers can be decomposed into monomers in the presence of FeCl3 , GdCl3 or C60 (OH)22 , but associated into tetramers in the presence of Gd@C82 (OH)22 . Gadolinium 102-104 transferrin Homo sapiens 29-31 29025775-0 2017 A unique case of nephrogenic systemic fibrosis from gadolinium exposure in a patient with normal eGFR. Gadolinium 52-62 epidermal growth factor receptor Homo sapiens 97-101 28874655-0 2017 Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Function. Gadolinium 146-156 lipocalin 2 Homo sapiens 6-85 28587741-6 2017 Big endothelin-1 was positively correlated with N-terminal B-type natriuretic peptide (r=0.291, p<0.001) and late gadolinium enhancement (LGE) on magnetic resonance imaging (r=0.222, p=0.016). Gadolinium 117-127 endothelin 1 Homo sapiens 4-16 28802830-6 2017 Most importantly, a highly significant correlation could be observed between GFAP levels and the intensity of gadolinium-enhancement as a parameter for the acute activity of inflammatory processes (p=0.0002). Gadolinium 110-120 glial fibrillary acidic protein Homo sapiens 77-81 29038105-0 2017 Letter by Di Marco et al Regarding Article, "Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging". Gadolinium 199-209 macrophage receptor with collagenous structure Homo sapiens 13-18 28874655-5 2017 RESULTS After 24 hours, serum NGAL increase of >=25% was noticed in 32.6% of the patients in the iopromide group and in 25.45% of the patients in the gadolinium group, with significantly higher average percent of this increase in first group (62.23% vs. 36.44%, p=0.002). Gadolinium 153-163 lipocalin 2 Homo sapiens 30-34 28874655-8 2017 CONCLUSIONS In children with normal renal function, exposure to iodinated-based and gadolinium-based media might lead to subclinical nephrotoxicity, which could be detected using serum NGAL and urinary KIM-1. Gadolinium 84-94 lipocalin 2 Homo sapiens 185-189 28874655-8 2017 CONCLUSIONS In children with normal renal function, exposure to iodinated-based and gadolinium-based media might lead to subclinical nephrotoxicity, which could be detected using serum NGAL and urinary KIM-1. Gadolinium 84-94 hepatitis A virus cellular receptor 1 Homo sapiens 202-207 28765707-2 2017 In this study, the MRI contrast agent, vascular endothelial growth factor receptor (VEGFR)-targeted poly (l-lysine) (PLL)-diethylene triamine pentacetate acid (DTPA)-gadolinium (Gd) (VEGFR-targeted PLL-DTPA-Gd, VPDG), was designed and prepared to enhance the MRI diagnosis capacity of tumor. Gadolinium 166-176 kinase insert domain receptor Homo sapiens 39-82 28856010-0 2017 Serum netrin-1 in relation to gadolinium-enhanced magnetic resonance imaging in early multiple sclerosis. Gadolinium 30-40 netrin 1 Homo sapiens 6-14 28856010-7 2017 Among gadolinium+ patients, serum netrin-1 was decreased in clinically active (n = 8) vs non-active patients (n = 39; p = 0.041). Gadolinium 6-16 netrin 1 Homo sapiens 34-42 28588076-5 2017 METHODS: Cardiac fibrosis in subjects with homozygous mutation in SERPINE-1 was evaluated with late gadolinium-enhanced cardiac magnetic resonance imaging. Gadolinium 100-110 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 66-75 28640996-3 2017 Therefore, we describe the development of Gd-containing polyoxometalates-conjugated chitosan (GdW10@CS nanosphere) as a radiosensitization system for simultaneous extrinsic and intrinsic radiosensitization, by generating an overabundance of cytotoxic reactive oxygen species (ROS) using high-energy X-ray stimulation and mediating the hypoxia-inducible factor-1a (HIF-1a) siRNA to down-regulate HIF-1alpha expression and suppress broken double-stranded DNA self-healing. Gadolinium 42-44 hypoxia inducible factor 1 subunit alpha Homo sapiens 335-362 28640996-3 2017 Therefore, we describe the development of Gd-containing polyoxometalates-conjugated chitosan (GdW10@CS nanosphere) as a radiosensitization system for simultaneous extrinsic and intrinsic radiosensitization, by generating an overabundance of cytotoxic reactive oxygen species (ROS) using high-energy X-ray stimulation and mediating the hypoxia-inducible factor-1a (HIF-1a) siRNA to down-regulate HIF-1alpha expression and suppress broken double-stranded DNA self-healing. Gadolinium 42-44 hypoxia inducible factor 1 subunit alpha Homo sapiens 364-370 28640996-3 2017 Therefore, we describe the development of Gd-containing polyoxometalates-conjugated chitosan (GdW10@CS nanosphere) as a radiosensitization system for simultaneous extrinsic and intrinsic radiosensitization, by generating an overabundance of cytotoxic reactive oxygen species (ROS) using high-energy X-ray stimulation and mediating the hypoxia-inducible factor-1a (HIF-1a) siRNA to down-regulate HIF-1alpha expression and suppress broken double-stranded DNA self-healing. Gadolinium 42-44 hypoxia inducible factor 1 subunit alpha Homo sapiens 395-405 28765707-2 2017 In this study, the MRI contrast agent, vascular endothelial growth factor receptor (VEGFR)-targeted poly (l-lysine) (PLL)-diethylene triamine pentacetate acid (DTPA)-gadolinium (Gd) (VEGFR-targeted PLL-DTPA-Gd, VPDG), was designed and prepared to enhance the MRI diagnosis capacity of tumor. Gadolinium 166-176 kinase insert domain receptor Homo sapiens 84-89 28765707-2 2017 In this study, the MRI contrast agent, vascular endothelial growth factor receptor (VEGFR)-targeted poly (l-lysine) (PLL)-diethylene triamine pentacetate acid (DTPA)-gadolinium (Gd) (VEGFR-targeted PLL-DTPA-Gd, VPDG), was designed and prepared to enhance the MRI diagnosis capacity of tumor. Gadolinium 166-176 kinase insert domain receptor Homo sapiens 183-188 28765707-2 2017 In this study, the MRI contrast agent, vascular endothelial growth factor receptor (VEGFR)-targeted poly (l-lysine) (PLL)-diethylene triamine pentacetate acid (DTPA)-gadolinium (Gd) (VEGFR-targeted PLL-DTPA-Gd, VPDG), was designed and prepared to enhance the MRI diagnosis capacity of tumor. Gadolinium 178-180 kinase insert domain receptor Homo sapiens 39-82 28765707-2 2017 In this study, the MRI contrast agent, vascular endothelial growth factor receptor (VEGFR)-targeted poly (l-lysine) (PLL)-diethylene triamine pentacetate acid (DTPA)-gadolinium (Gd) (VEGFR-targeted PLL-DTPA-Gd, VPDG), was designed and prepared to enhance the MRI diagnosis capacity of tumor. Gadolinium 178-180 kinase insert domain receptor Homo sapiens 84-89 28603956-5 2017 MMP-2 cleaved the peptide substrates and released Gd chelates from the local magnetic fields accompanied by T1 relaxivity recovery and T1 contrast enhancement. Gadolinium 50-52 matrix metallopeptidase 2 Homo sapiens 0-5 28581764-2 2017 Herein, we report on a tumor-targeting, gadolinium biomineralized human transferrin (Tf) protein-based nanoparticle (Gd@Tf NP) for MRI use. Gadolinium 40-50 transferrin Homo sapiens 72-83 28581764-2 2017 Herein, we report on a tumor-targeting, gadolinium biomineralized human transferrin (Tf) protein-based nanoparticle (Gd@Tf NP) for MRI use. Gadolinium 40-50 transferrin Homo sapiens 85-87 28581764-3 2017 As compared to the conventionally used gadolinium chelates, the resultant Gd@Tf NPs possess outstanding chemical stability and exhibited superior longitudinal relaxation. Gadolinium 39-49 transferrin Homo sapiens 77-79 27865783-6 2017 Reduced levels of BDNF (p=0.004) and elevated levels of TNF-alpha (p=0.017) and IL-4 (p=0.035) were also found in the GD group. Gadolinium 118-120 brain derived neurotrophic factor Homo sapiens 18-22 28557803-0 2017 Grueneisen-approach for the experimental determination of transient spin and phonon energies from ultrafast x-ray diffraction data: gadolinium. Gadolinium 132-142 spindlin 1 Homo sapiens 68-72 28437081-7 2017 It is then suggested that the improved PL properties of gadolinium(III) originate from the increased UV transparency of the host and the consequent precluding of a nonradiative energy transfer from Gd3+ to the matrix. Gadolinium 56-66 GRDX Homo sapiens 198-201 27982684-4 2017 Results showed that there were GD-responsive neurons in VMH; Nesfatin-1 administration and electrical stimulation of hippocampal CA1 sub-region altered the firing rate of these neurons. Gadolinium 31-33 nucleobindin 2 Rattus norvegicus 61-71 27982684-4 2017 Results showed that there were GD-responsive neurons in VMH; Nesfatin-1 administration and electrical stimulation of hippocampal CA1 sub-region altered the firing rate of these neurons. Gadolinium 31-33 carbonic anhydrase 1 Rattus norvegicus 129-132 27982684-6 2017 Electrolytic lesion of CA1 hippocampus reduced the effects of nesfatin-1 on VMH GD-responsive neuronal activity. Gadolinium 80-82 carbonic anhydrase 1 Rattus norvegicus 23-26 27982684-6 2017 Electrolytic lesion of CA1 hippocampus reduced the effects of nesfatin-1 on VMH GD-responsive neuronal activity. Gadolinium 80-82 nucleobindin 2 Rattus norvegicus 62-72 28039317-8 2017 At month 60, mean cumulative numbers of new T2, gadolinium-enhancing and T1 hypointense lesions were lower with sc IFN beta-1a qw (nominal p<0.05) and tiw versus DT (nominal p<0.001); T2 and T1 hypointense lesion volume change was lower for sc IFN beta-1a tiw versus DT (nominal p<0.01). Gadolinium 48-58 interferon beta 1 Homo sapiens 115-123 28340590-8 2017 Results indicate that the mean angle was different between Dob-CSM and GD-CSM at C4-5, C5-6, and C6-7, and between GD-N and GD-CSM at C6-7. Gadolinium 71-73 complement C5 Canis lupus familiaris 81-85 28340590-8 2017 Results indicate that the mean angle was different between Dob-CSM and GD-CSM at C4-5, C5-6, and C6-7, and between GD-N and GD-CSM at C6-7. Gadolinium 71-73 complement C6 Canis lupus familiaris 97-101 28481080-3 2017 This work describes the specific and sustained in vivo binding and retention of a protein tyrosine phosphatase mu (PTPmu)-targeted, molecular magnetic resonance (MR) contrast agent with a single gadolinium (Gd) chelate using a quantitative MRI T1 mapping technique in glioma xenografts. Gadolinium 195-205 protein tyrosine phosphatase receptor type M Homo sapiens 82-113 28481080-3 2017 This work describes the specific and sustained in vivo binding and retention of a protein tyrosine phosphatase mu (PTPmu)-targeted, molecular magnetic resonance (MR) contrast agent with a single gadolinium (Gd) chelate using a quantitative MRI T1 mapping technique in glioma xenografts. Gadolinium 195-205 protein tyrosine phosphatase receptor type M Homo sapiens 115-120 28481080-3 2017 This work describes the specific and sustained in vivo binding and retention of a protein tyrosine phosphatase mu (PTPmu)-targeted, molecular magnetic resonance (MR) contrast agent with a single gadolinium (Gd) chelate using a quantitative MRI T1 mapping technique in glioma xenografts. Gadolinium 207-209 protein tyrosine phosphatase receptor type M Homo sapiens 82-113 28481080-3 2017 This work describes the specific and sustained in vivo binding and retention of a protein tyrosine phosphatase mu (PTPmu)-targeted, molecular magnetic resonance (MR) contrast agent with a single gadolinium (Gd) chelate using a quantitative MRI T1 mapping technique in glioma xenografts. Gadolinium 207-209 protein tyrosine phosphatase receptor type M Homo sapiens 115-120 28481080-8 2017 Following complexation with Gd, this PTPmu-targeted molecular contrast agent containing a single Gd ion showed significant tumor enhancement and a sustained increase in Gd concentration in both heterotopic and orthotopic tumors using dynamic quantitative MRI. Gadolinium 28-30 protein tyrosine phosphatase receptor type M Homo sapiens 37-42 28451627-1 2017 OBJECTIVE: To describe leptomeningeal blood-barrier impairment reflected by MRI gadolinium-enhanced lesions in patients with aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD). Gadolinium 80-90 aquaporin 4 Homo sapiens 155-159 28159799-9 2017 A graded association was observed between higher baseline hs-cTnT categories and late gadolinium enhancement (>=7.42 ng/L versus <limit of detection [<3 ng/L]; adjusted odds ratio, 2.87; 95% confidence interval, 1.38-5.94). Gadolinium 86-96 troponin T2, cardiac type Homo sapiens 61-65 28533887-11 2017 As expected, the TRPM7 inhibitors gadolinium and 2-Aminoethoxydiphenyl borate have similar effects on TRPM7 currents and proliferation of C6 cells. Gadolinium 34-44 transient receptor potential cation channel subfamily M member 7 Homo sapiens 17-22 28533887-11 2017 As expected, the TRPM7 inhibitors gadolinium and 2-Aminoethoxydiphenyl borate have similar effects on TRPM7 currents and proliferation of C6 cells. Gadolinium 34-44 transient receptor potential cation channel subfamily M member 7 Homo sapiens 102-107 28202518-4 2017 We fused human placental lactogen (hPL), a specific and tight binding PRLR ligand, to magnetic resonance imaging (gadolinium) and near-infrared fluorescence imaging agents. Gadolinium 114-124 chorionic somatomammotropin hormone 2 Homo sapiens 15-33 27865783-6 2017 Reduced levels of BDNF (p=0.004) and elevated levels of TNF-alpha (p=0.017) and IL-4 (p=0.035) were also found in the GD group. Gadolinium 118-120 tumor necrosis factor Homo sapiens 56-65 27865783-6 2017 Reduced levels of BDNF (p=0.004) and elevated levels of TNF-alpha (p=0.017) and IL-4 (p=0.035) were also found in the GD group. Gadolinium 118-120 interleukin 4 Homo sapiens 80-84 28161832-2 2017 Gadolinium (Gd) compounds can be used as MRI contrast agents, however the release of Gd3+ ions presents some adverse side effects such as renal failure, pancreatitis or local necrosis. Gadolinium 0-10 GRDX Homo sapiens 85-88 28078622-7 2017 Non-specific PKD2 channel inhibitors Neo (neomycin) and Gd3+ (gadolinium) inhibit both prey capture and cnidocyte discharge in hydra. Gadolinium 62-72 polycystin 2, transient receptor potential cation channel Homo sapiens 13-17 28161832-2 2017 Gadolinium (Gd) compounds can be used as MRI contrast agents, however the release of Gd3+ ions presents some adverse side effects such as renal failure, pancreatitis or local necrosis. Gadolinium 12-14 GRDX Homo sapiens 85-88 28148632-9 2017 Higher and increasing NfL predicted higher number of gadolinium-enhancing lesions (p < 0.001 for both). Gadolinium 53-63 neurofilament light chain Homo sapiens 22-25 27673510-1 2017 Purpose To measure the levels of gadolinium present in the rat brain 1 and 20 weeks after dosing with contrast agent and to determine if there are any histopathologic sequelae. Gadolinium 33-43 POU class 3 homeobox 3 Rattus norvegicus 63-77 27207449-5 2017 RESULTS: For patients continuing DMF BID (BID/BID), annualized relapse rates were 0.202, 0.163, 0.139, 0.143, and 0.138 (years 1-5, respectively) and 63%, 73%, and 88% were free of new or enlarging T2 hyperintense lesions, new T1 hypointense lesions, and gadolinium-enhanced lesions, respectively, at year 5. Gadolinium 255-265 BH3 interacting domain death agonist Homo sapiens 42-45 27833932-3 2017 Response to conventional treatment (corticosteroids and interferon) and targeted treatment with a BRAF inhibitor was assessed by clinical evaluation, gadolinium-enhanced MRI brain scan, and serial testing of urinary cell-free DNA for mutant alleles. Gadolinium 150-160 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 98-102 28168166-5 2017 We performed pretreatment contrast-enhanced planning CT and gadolinium-enhanced PET/MRI. Gadolinium 60-70 cell cycle regulator of NHEJ Homo sapiens 80-87 28117790-1 2017 A method for determining the presence of unchelated trivalent gadolinium ion (Gd3+) in aqueous solution is demonstrated. Gadolinium 62-72 GRDX Homo sapiens 78-81 28117790-2 2017 Gd3+ is often present in samples of gadolinium-based contrast agents as a result of incomplete reactions between the ligand and the ion, or as a dissociation product. Gadolinium 36-46 GRDX Homo sapiens 0-3 29085555-8 2017 Inhibition of Rac-1 and NOX2 suppressed GD-induced oxidative stress and protected photoreceptors against GD-induced cell death. Gadolinium 40-42 Rac family small GTPase 1 Mus musculus 14-19 29085555-8 2017 Inhibition of Rac-1 and NOX2 suppressed GD-induced oxidative stress and protected photoreceptors against GD-induced cell death. Gadolinium 40-42 cytochrome b-245, beta polypeptide Mus musculus 24-28 29085555-8 2017 Inhibition of Rac-1 and NOX2 suppressed GD-induced oxidative stress and protected photoreceptors against GD-induced cell death. Gadolinium 105-107 Rac family small GTPase 1 Mus musculus 14-19 29085555-8 2017 Inhibition of Rac-1 and NOX2 suppressed GD-induced oxidative stress and protected photoreceptors against GD-induced cell death. Gadolinium 105-107 cytochrome b-245, beta polypeptide Mus musculus 24-28 29085555-10 2017 In addition, GD caused the activation of NF-kappaB signal and inhibiting NF-kappaB significantly protected 661W cells. Gadolinium 13-15 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 41-50 27869664-8 2016 GD also inhibited tyrosinase enzymatic activity. Gadolinium 0-2 tyrosinase Homo sapiens 18-28 27767308-7 2016 For calculations that correctly predict a 10D ground state for Gd+, good agreement between theoretical and measured GdC+ and GdCO+ BDEs is obtained, whereas the GdO+ BDE is underestimated in these calculations by about 0.8 eV. Gadolinium 63-65 homeobox D13 Homo sapiens 131-134 27207449-5 2017 RESULTS: For patients continuing DMF BID (BID/BID), annualized relapse rates were 0.202, 0.163, 0.139, 0.143, and 0.138 (years 1-5, respectively) and 63%, 73%, and 88% were free of new or enlarging T2 hyperintense lesions, new T1 hypointense lesions, and gadolinium-enhanced lesions, respectively, at year 5. Gadolinium 255-265 BH3 interacting domain death agonist Homo sapiens 42-45 29318141-13 2017 In conclusion, the activity of glucose-sensitive neurons and GD-sensitive neurons in the hypothalamus and DVC can be modulated by alpha-MSH. Gadolinium 61-63 proopiomelanocortin Rattus norvegicus 130-139 28013302-0 2017 TREX1 Mutation in Leukodystrophy with Calcifications and Persistent Gadolinium-Enhancement. Gadolinium 68-78 three prime repair exonuclease 1 Homo sapiens 0-5 27898346-5 2017 The metabolic sensor AMP kinase (AMPK) is activated when glycolysis is decreased, and the induction of Bcl6 by GD was inhibited by the AMPK antagonist compound C. Additionally, activation of AMPK by the drug AICAR caused Bcl6 up-regulation in activated CD4 T cells. Gadolinium 111-113 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 21-31 27898346-5 2017 The metabolic sensor AMP kinase (AMPK) is activated when glycolysis is decreased, and the induction of Bcl6 by GD was inhibited by the AMPK antagonist compound C. Additionally, activation of AMPK by the drug AICAR caused Bcl6 up-regulation in activated CD4 T cells. Gadolinium 111-113 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 33-37 27898346-5 2017 The metabolic sensor AMP kinase (AMPK) is activated when glycolysis is decreased, and the induction of Bcl6 by GD was inhibited by the AMPK antagonist compound C. Additionally, activation of AMPK by the drug AICAR caused Bcl6 up-regulation in activated CD4 T cells. Gadolinium 111-113 BCL6 transcription repressor Homo sapiens 103-107 27898346-5 2017 The metabolic sensor AMP kinase (AMPK) is activated when glycolysis is decreased, and the induction of Bcl6 by GD was inhibited by the AMPK antagonist compound C. Additionally, activation of AMPK by the drug AICAR caused Bcl6 up-regulation in activated CD4 T cells. Gadolinium 111-113 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 135-139 27898346-5 2017 The metabolic sensor AMP kinase (AMPK) is activated when glycolysis is decreased, and the induction of Bcl6 by GD was inhibited by the AMPK antagonist compound C. Additionally, activation of AMPK by the drug AICAR caused Bcl6 up-regulation in activated CD4 T cells. Gadolinium 111-113 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 135-139 27898346-5 2017 The metabolic sensor AMP kinase (AMPK) is activated when glycolysis is decreased, and the induction of Bcl6 by GD was inhibited by the AMPK antagonist compound C. Additionally, activation of AMPK by the drug AICAR caused Bcl6 up-regulation in activated CD4 T cells. Gadolinium 111-113 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Homo sapiens 208-213 27898346-5 2017 The metabolic sensor AMP kinase (AMPK) is activated when glycolysis is decreased, and the induction of Bcl6 by GD was inhibited by the AMPK antagonist compound C. Additionally, activation of AMPK by the drug AICAR caused Bcl6 up-regulation in activated CD4 T cells. Gadolinium 111-113 BCL6 transcription repressor Homo sapiens 221-225 29085555-10 2017 In addition, GD caused the activation of NF-kappaB signal and inhibiting NF-kappaB significantly protected 661W cells. Gadolinium 13-15 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 73-82 27580520-2 2016 GBCM targets iron-recycling CD163- and ferroportin-expressing macrophages to release labile iron that mediates gadolinium toxicity and NSF. Gadolinium 111-121 CD163 molecule Homo sapiens 28-33 27718463-13 2016 Furthermore, using the developed method, the adducted BChE levels from VX and GD-exposed (0.10-100ngmL-1) plasma samples were completely characterized, and the fact that VX being more active and specific to BChE than GD was re-confirmed. Gadolinium 78-80 butyrylcholinesterase Homo sapiens 54-58 27718463-13 2016 Furthermore, using the developed method, the adducted BChE levels from VX and GD-exposed (0.10-100ngmL-1) plasma samples were completely characterized, and the fact that VX being more active and specific to BChE than GD was re-confirmed. Gadolinium 78-80 butyrylcholinesterase Homo sapiens 207-211 27080329-5 2016 Orexin-A administration to the Hi excited most of the GD-excitatory (GD-E) neurons and GD-inhibitory (GD-I) neurons, and increased gastric motility in a dose-dependent manner. Gadolinium 54-56 hypocretin neuropeptide precursor Rattus norvegicus 0-8 27573189-8 2016 Gadolinium downregulated the expression levels of TGFbetaRI and small mothers against decapentaplegic (Smad)2/3, and decreased the levels of phosphorylated p38, ERK1/2 and JNK. Gadolinium 0-10 SMAD family member 2 Homo sapiens 103-111 27573189-8 2016 Gadolinium downregulated the expression levels of TGFbetaRI and small mothers against decapentaplegic (Smad)2/3, and decreased the levels of phosphorylated p38, ERK1/2 and JNK. Gadolinium 0-10 mitogen-activated protein kinase 1 Homo sapiens 156-159 27573189-8 2016 Gadolinium downregulated the expression levels of TGFbetaRI and small mothers against decapentaplegic (Smad)2/3, and decreased the levels of phosphorylated p38, ERK1/2 and JNK. Gadolinium 0-10 mitogen-activated protein kinase 3 Homo sapiens 161-167 27573189-8 2016 Gadolinium downregulated the expression levels of TGFbetaRI and small mothers against decapentaplegic (Smad)2/3, and decreased the levels of phosphorylated p38, ERK1/2 and JNK. Gadolinium 0-10 mitogen-activated protein kinase 8 Homo sapiens 172-175 27573189-9 2016 In addition, gadolinium reversed the collagen-induced activation of p38 and ERK1/2. Gadolinium 13-23 mitogen-activated protein kinase 1 Homo sapiens 68-71 27573189-9 2016 In addition, gadolinium reversed the collagen-induced activation of p38 and ERK1/2. Gadolinium 13-23 mitogen-activated protein kinase 3 Homo sapiens 76-82 27573189-10 2016 In the presence of gadolinium and anti-beta1 integrin antibody, collagen regulated the expression levels of TGFbetaRI, TGFbetaRII and Smad2/3, but did not alter the phosphorylation of p38, ERK1/2 or JNK. Gadolinium 19-29 SMAD family member 2 Homo sapiens 134-141 27573189-10 2016 In the presence of gadolinium and anti-beta1 integrin antibody, collagen regulated the expression levels of TGFbetaRI, TGFbetaRII and Smad2/3, but did not alter the phosphorylation of p38, ERK1/2 or JNK. Gadolinium 19-29 mitogen-activated protein kinase 1 Homo sapiens 184-187 27573189-10 2016 In the presence of gadolinium and anti-beta1 integrin antibody, collagen regulated the expression levels of TGFbetaRI, TGFbetaRII and Smad2/3, but did not alter the phosphorylation of p38, ERK1/2 or JNK. Gadolinium 19-29 mitogen-activated protein kinase 3 Homo sapiens 189-195 27573189-10 2016 In the presence of gadolinium and anti-beta1 integrin antibody, collagen regulated the expression levels of TGFbetaRI, TGFbetaRII and Smad2/3, but did not alter the phosphorylation of p38, ERK1/2 or JNK. Gadolinium 19-29 mitogen-activated protein kinase 8 Homo sapiens 199-202 27221979-12 2016 The functional role of chemokines in the effects of gadolinium-based contrast was further confirmed in in situ coculture studies using neutralizing CCR2 antibodies. Gadolinium 52-62 C-C motif chemokine receptor 2 Homo sapiens 148-152 27660437-9 2016 Furthermore, Gd-doped CDs significantly increased the circulation time and decreased the toxicity of Gd3+ in in vitro and in vivo magnetic resonance imaging, which demonstrated that the AFn nanocages labeled with Gd-CD compounds could serve as an excellent T1 contrast agent for magnetic resonance imaging. Gadolinium 13-15 ferritin heavy chain 1 Homo sapiens 186-189 27080329-5 2016 Orexin-A administration to the Hi excited most of the GD-excitatory (GD-E) neurons and GD-inhibitory (GD-I) neurons, and increased gastric motility in a dose-dependent manner. Gadolinium 69-71 hypocretin neuropeptide precursor Rattus norvegicus 0-8 27348438-2 2016 ONDs bearing gadolinium chelates as model cargos exhibited variable conjugation efficiencies with albumin in rat subjects that are consistent with the observed reactivity of each linker and their observed stability toward serum hydrolases in vitro. Gadolinium 13-23 albumin Rattus norvegicus 98-105 27348438-3 2016 The terminal elimination rate from circulation was dependent on the identity of the OND used, and increased circulation time of gadolinium cargo was achieved for linkers bearing electrophilic fragments designed to react with cysteine-34 of circulating serum albumin. Gadolinium 128-138 albumin Rattus norvegicus 258-265 27385778-8 2016 Extracellular La(3+) and Gd(3+) rapidly and reversibly blocked the induced Pro(2+) influx and markedly delayed pyroptotic lysis without limiting upstream inflammasome assembly and caspase-1 activation. Gadolinium 25-27 caspase 1 Mus musculus 180-189 27300300-4 2016 In this study, BSA-DTPA(Gd) derived from bovine serum albumin (BSA) as a novel kind of biotemplate is employed for biomineralization of paramagnetic NIR Ag2S quantum dots (denoted as Ag2S@BSA-DTPA(Gd) pQDs). Gadolinium 24-26 angiotensin II receptor type 1 Homo sapiens 153-157 27219819-5 2016 RESULTS: At 12 months after MSC infusion, the mean ARR was reduced (1.1 vs. 0.3, P = 0.002), and the T2 or gadolinium-enhancing T1 lesions decreased in the optic nerve and spinal cord. Gadolinium 107-117 musculin Homo sapiens 28-31 27350016-4 2016 Diagnosis of TTR-CA was based on echocardiography and either gadolinium-enhanced (LGE) cardiac magnetic resonance (cMRI) or radionuclide imaging. Gadolinium 61-71 transthyretin Homo sapiens 13-16 27455834-5 2016 In the present study, we have functionalized gadolinium-based MRI nanoparticles (AGuIX) with peptides highly specific for Abeta amyloid fibrils, LPFFD and KLVFF. Gadolinium 45-55 amyloid beta precursor protein Homo sapiens 122-127 27468213-8 2016 In addition, increased MDR1 expression was observed in GD-treated CRC cells. Gadolinium 55-57 ATP binding cassette subfamily B member 1 Homo sapiens 23-27 27436489-6 2016 Chemical TRPV4 inhibitors (HC-067047 and Gadolinium) or TRPV4 knockout, but not TRPV1 inhibitor SB-705498, could restore the water intake under hypoxia. Gadolinium 41-51 transient receptor potential cation channel, subfamily V, member 4 Rattus norvegicus 9-14 27300300-4 2016 In this study, BSA-DTPA(Gd) derived from bovine serum albumin (BSA) as a novel kind of biotemplate is employed for biomineralization of paramagnetic NIR Ag2S quantum dots (denoted as Ag2S@BSA-DTPA(Gd) pQDs). Gadolinium 24-26 angiotensin II receptor type 1 Homo sapiens 183-187 27300300-4 2016 In this study, BSA-DTPA(Gd) derived from bovine serum albumin (BSA) as a novel kind of biotemplate is employed for biomineralization of paramagnetic NIR Ag2S quantum dots (denoted as Ag2S@BSA-DTPA(Gd) pQDs). Gadolinium 197-199 angiotensin II receptor type 1 Homo sapiens 153-157 27300300-4 2016 In this study, BSA-DTPA(Gd) derived from bovine serum albumin (BSA) as a novel kind of biotemplate is employed for biomineralization of paramagnetic NIR Ag2S quantum dots (denoted as Ag2S@BSA-DTPA(Gd) pQDs). Gadolinium 197-199 angiotensin II receptor type 1 Homo sapiens 183-187 27300300-10 2016 In vivo tumor-bearing MR and fluorescence imaging both demonstrate that Ag2S@BSA-DTPA(Gd) pQDs have pronounced tiny tumor targeting capability. Gadolinium 86-88 angiotensin II receptor type 1 Homo sapiens 72-76 27300300-11 2016 In vitro and in vivo toxicity study show Ag2S@BSA-DTPA(Gd) pQDs are biocompatible. Gadolinium 55-57 angiotensin II receptor type 1 Homo sapiens 41-45 27300300-13 2016 This protein-mediated biomineralized Ag2S@BSA-DTPA(Gd) pQDs presents great potential as a novel bimodal imaging contrast agent for tiny tumor diagnosis. Gadolinium 51-53 angiotensin II receptor type 1 Homo sapiens 37-41 26991559-9 2016 The proportion of patients with gadolinium-enhancing lesions reduced significantly during IFN beta. Gadolinium 32-42 interferon beta 1 Homo sapiens 90-98 27175589-7 2016 Meanwhile, overexpression of Pinin attenuates GD initiated poly ADP-ribose polymerase (PARP) cleavage and ERK1/2 dephosphorylation, which can be completely blocked with MEK1/2 inhibitor U0126. Gadolinium 46-48 pinin, desmosome associated protein Homo sapiens 29-34 27316702-3 2016 Gadolinium-based metallofullerenols, e.g., Gd@C82(OH) x (x 22), are well known for their abundant biological activities with low toxicity experimentally and theoretically; however, their activity in direct TNF-alpha inhibition has not been explored. Gadolinium 43-45 complement C8 beta chain Homo sapiens 46-49 27316702-3 2016 Gadolinium-based metallofullerenols, e.g., Gd@C82(OH) x (x 22), are well known for their abundant biological activities with low toxicity experimentally and theoretically; however, their activity in direct TNF-alpha inhibition has not been explored. Gadolinium 43-45 tumor necrosis factor Homo sapiens 208-217 27175589-7 2016 Meanwhile, overexpression of Pinin attenuates GD initiated poly ADP-ribose polymerase (PARP) cleavage and ERK1/2 dephosphorylation, which can be completely blocked with MEK1/2 inhibitor U0126. Gadolinium 46-48 poly(ADP-ribose) polymerase 1 Homo sapiens 59-85 27175589-7 2016 Meanwhile, overexpression of Pinin attenuates GD initiated poly ADP-ribose polymerase (PARP) cleavage and ERK1/2 dephosphorylation, which can be completely blocked with MEK1/2 inhibitor U0126. Gadolinium 46-48 poly(ADP-ribose) polymerase 1 Homo sapiens 87-91 27223075-6 2016 Taken together, these studies indicate that Cy5.5-Tf-DTPA-Gd could be a good agent for MR/NIRF dual mode applications to detect both tumor in situ and its metastasis. Gadolinium 58-60 ubiquitin-like, containing PHD and RING finger domains 2 Mus musculus 90-94 27175589-7 2016 Meanwhile, overexpression of Pinin attenuates GD initiated poly ADP-ribose polymerase (PARP) cleavage and ERK1/2 dephosphorylation, which can be completely blocked with MEK1/2 inhibitor U0126. Gadolinium 46-48 mitogen-activated protein kinase kinase 1 Homo sapiens 169-175 27341338-0 2016 Thermal Excitation of Gadolinium-Based Contrast Agents Using Spin Resonance. Gadolinium 22-32 spindlin 1 Homo sapiens 61-65 27341338-2 2016 The electronic spin-lattice relaxation time tau1e of gadolinium-based contrast agents, which is estimated at 0.1 ns, is ten orders of magnitude faster than the relaxation time of protons in water. Gadolinium 53-63 spindlin 1 Homo sapiens 15-19 27097822-1 2016 A macromolecular magnetic resonance imaging (MRI) contrast agent was successfully synthesized by conjugating the gadolinium/1,4,7,10-tetraazacyclododecane-1,4,7-tetracetic acid complex (Gd-DO3A) with 6,6-phenyl-C61 butyric acid (PC61BA) and upon further modification with human serum albumin (HSA). Gadolinium 113-123 macoilin 1 Mus musculus 211-214 26537620-12 2016 In an adjusted multivariate model, African origin, neuropathy, carpal tunnel syndrome, electrocardiogram (ECG) low voltage, and late gadolinium enhancement (LGE) at cardiac-magnetic resonance imaging were all independently associated with mTTR-FAC. Gadolinium 133-143 transthyretin Mus musculus 239-243 27035336-5 2016 Single-targeting agent anti-EGFR-DTPA-Gd, which served as the control, was also prepared. Gadolinium 38-40 epidermal growth factor receptor Homo sapiens 28-32 27188600-1 2016 Reaction of (aminomethyl)phosphonic acid (ampH2) with a mixture of gadolinium and cobalt pivalates under solvothermal conditions, led to a pseudo-icosahedral cage {Gd12}, which shows a large magnetocaloric effect (MCE). Gadolinium 67-77 bridging integrator 1 Homo sapiens 42-47 27126965-1 2016 The newly obtained complexes [NiLn(Piv)16(teaH)6(OCH3)2(CO3)2(H2O)2] Ln = Gd, Dy, show a remarkable mu5-carbonate bridged octanuclear planar {Ni4Ln4} core further capped with embedded {Ni3Ln} cubane motifs to afford a rod shaped nano-sized molecule of about 1.2 x 2.8 nm. Gadolinium 74-76 adaptor related protein complex 5 subunit mu 1 Homo sapiens 100-103 27097822-1 2016 A macromolecular magnetic resonance imaging (MRI) contrast agent was successfully synthesized by conjugating the gadolinium/1,4,7,10-tetraazacyclododecane-1,4,7-tetracetic acid complex (Gd-DO3A) with 6,6-phenyl-C61 butyric acid (PC61BA) and upon further modification with human serum albumin (HSA). Gadolinium 113-123 albumin Mus musculus 284-291 27139734-7 2016 In multivariate Cox regression analysis, extent of late gadolinium enhancement was the only independent predictor of outcome events on cardiac magnetic resonance imaging, with a hazard ratio of 2.22 per tertile (95% CI 1.07-4.59). Gadolinium 56-66 cytochrome c oxidase subunit 8A Homo sapiens 16-19 26626406-6 2016 We speculate that a different pathway resulting in mTOR activation is the basis of both TSC and MB in this child; H&E, haematoxilin and eosin; Gd, gadolinium. Gadolinium 147-157 mechanistic target of rapamycin kinase Homo sapiens 51-55 26460054-0 2016 Dark Blood Magnetic Resonance Lymphangiography Using Dual-Agent Relaxivity Contrast (DARC-MRL): A Novel Method Combining Gadolinium and Iron Contrast Agents. Gadolinium 121-131 atypical chemokine receptor 1 (Duffy blood group) Homo sapiens 85-89 26914970-7 2016 Gadolinium enhancement on MRI was observed in 31.25% of PML-IRIS cases versus 2.56% of PML non-IRIS (P < 0.01). Gadolinium 0-10 PML nuclear body scaffold Homo sapiens 56-59 26914970-7 2016 Gadolinium enhancement on MRI was observed in 31.25% of PML-IRIS cases versus 2.56% of PML non-IRIS (P < 0.01). Gadolinium 0-10 PML nuclear body scaffold Homo sapiens 87-90 26953564-1 2016 OBJECTIVE: The aim of this study was to assess gadolinium deposition in the skin of a patient with normal renal function, based on estimated glomerular filtration rate values greater than 59 mL/min/1.73 m(2) after exposure to large cumulative doses of gadolinium-based contrast agents (GBCAs). Gadolinium 47-57 CD59 molecule (CD59 blood group) Homo sapiens 194-199 27398022-9 2016 CONCLUSIONS: Urinary IL-18 and NAG levels increased transiently after administration of gadolinium-based contrast agents in patients with normal renal function. Gadolinium 88-98 interleukin 18 Homo sapiens 21-26 27398022-9 2016 CONCLUSIONS: Urinary IL-18 and NAG levels increased transiently after administration of gadolinium-based contrast agents in patients with normal renal function. Gadolinium 88-98 N-acetyl-alpha-glucosaminidase Homo sapiens 31-34 26445946-0 2016 Regression of gadolinium-enhanced lesions in patients affected by neurofibromatosis type 1. Gadolinium 14-24 neurofibromin 1 Homo sapiens 66-90 27047372-2 2016 Here, we have used in vivo gadolinium-stained high resolution (29(*)29(*)117 mum(3)) magnetic resonance imaging (MRI) to follow-up in a longitudinal way individual amyloid plaques in APP/PS1 mice and evaluate the efficacy of a new immunotherapy (SAR255952) directed against protofibrillar and fibrillary forms of Abeta. Gadolinium 27-37 presenilin 1 Mus musculus 187-190 26943959-4 2016 CSF YKL-40 was increased in patients with active relapsing-remitting MS and correlated with the number of gadolinium enhancing lesions. Gadolinium 106-116 chitinase 3 like 1 Homo sapiens 4-10 26303508-7 2016 In cultures exposed to GD and GR in the presence of D-BHB, the levels of LC3-II and p62 rapidly declined and remained low during GR, suggesting that the KB stimulates the autophagic flux preventing autophagosome accumulation and improving neuronal survival. Gadolinium 23-25 nucleoporin 62 Homo sapiens 84-87 26265140-4 2016 The purpose of this study was to synthesize a Gd-based contrast agent conjugated with specific antibodies to Cx43 for efficient visualization of glioma C6 in vivo. Gadolinium 46-48 gap junction protein alpha 1 Homo sapiens 109-113 25716934-5 2016 When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR = 2.36; 95% CI 1.21 to 4.59; p = 0.011), gadolinium-enhancing lesions (OR = 2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR = 2.54; 95% CI 1.21 to 5.31; p = 0.013) at CIS diagnosis. Gadolinium 179-189 neurofilament light chain Homo sapiens 41-44 26731190-7 2016 The morphogenetic activity of gadolinium, in the form of polyP Gd, is underscored by the finding that this polymer causes a strong upregulation of the genes encoding morphogenetic protein-2 (BMP2) as well as collagen type I. Gadolinium 30-40 bone morphogenetic protein 2 Homo sapiens 191-195 26740341-4 2016 Bovine serum albumin (BSA) bundled with DTPA-Gd(3+) (DTPA(Gd)) is synthesized both as the MR imaging sensitivity synergist and phase-transfer ligand for the surface engineering of UCNPs. Gadolinium 45-47 albumin Homo sapiens 7-20 26265140-5 2016 We have prepared stable nontoxic conjugates of monoclonal antibody to Cx43 and polylysine-DTPA ligands complexed with Gd(III), which are characterized by higher T1 relaxivity (6.5 mM(-1) s(-1) at 7 T) than the commercial agent Magnevist (3.4 mM(-1) s(-1)). Gadolinium 118-120 gap junction protein alpha 1 Homo sapiens 70-74 27326981-11 2016 Although rare, IgE-mediated reactions to gadolinium derivatives have been reported. Gadolinium 41-51 immunoglobulin heavy constant epsilon Homo sapiens 15-18 26413835-4 2016 Using calcium imaging, we show that AQP-mediated fast swelling kinetics also significantly increases the amplitude of calcium transients inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium. Gadolinium 150-160 transient receptor potential cation channel subfamily V member 4 Homo sapiens 202-242 26413835-4 2016 Using calcium imaging, we show that AQP-mediated fast swelling kinetics also significantly increases the amplitude of calcium transients inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium. Gadolinium 150-160 transient receptor potential cation channel subfamily V member 4 Homo sapiens 244-249 26733809-6 2015 Gadolinium and acetylsalicylic acid reduced these currents, and FMRFamide, zinc (at high concentrations) and N,N,N",N"-tetrakis-(2-piridilmetil)-ethylenediamine increased them, indicating that functional ASICs are composed of the subunits ASIC1, ASIC2, and ASIC3. Gadolinium 0-10 acid sensing ion channel subunit 1 Homo sapiens 239-244 26482030-2 2015 Simulants of nerve agent (such as GD, VX) and mustard gas, dimethyl 4-nitrophenyl phosphate and 2-chloroethyl ethyl sulfide, have been hydrolyzed and oxidized, respectively, to nontoxic products via a pair of pathways catalyzed by the same MOF. Gadolinium 34-36 lysine acetyltransferase 8 Homo sapiens 240-243 26733809-6 2015 Gadolinium and acetylsalicylic acid reduced these currents, and FMRFamide, zinc (at high concentrations) and N,N,N",N"-tetrakis-(2-piridilmetil)-ethylenediamine increased them, indicating that functional ASICs are composed of the subunits ASIC1, ASIC2, and ASIC3. Gadolinium 0-10 acid sensing ion channel subunit 2 Homo sapiens 246-251 26733809-6 2015 Gadolinium and acetylsalicylic acid reduced these currents, and FMRFamide, zinc (at high concentrations) and N,N,N",N"-tetrakis-(2-piridilmetil)-ethylenediamine increased them, indicating that functional ASICs are composed of the subunits ASIC1, ASIC2, and ASIC3. Gadolinium 0-10 acid sensing ion channel subunit 3 Homo sapiens 257-262 26471725-10 2015 On the other hand, Gd(3+) inhibited the LPA and Ang II induced change in [Ca(2+) ]i , but had no effect on the ET-1 and NE induced increase in [Ca(2+) ]i . Gadolinium 19-21 angiotensinogen Rattus norvegicus 48-54 26569115-0 2015 Diagnostic Magnetic Resonance Imaging of Atherosclerosis in Apolipoprotein E Knockout Mouse Model Using Macrophage-Targeted Gadolinium-Containing Synthetic Lipopeptide Nanoparticles. Gadolinium 124-134 apolipoprotein E Mus musculus 60-76 26613472-0 2015 Separating Exchange Splitting from Spin Mixing in Gadolinium by Femtosecond Laser Excitation. Gadolinium 50-60 spindlin 1 Homo sapiens 35-39 26336161-1 2015 Nephrogenic systemic fibrosis (NSF) is a devastating condition associated with gadolinium (Gd3+)-based contrast agents (GBCAs) in patients with kidney disease. Gadolinium 79-89 GRDX Homo sapiens 91-94 26129870-5 2015 Gadolinium administration caused a significant decrease in serum chitotriosidase activity in both controls (p<0.01) and poloxamer 407-induced hyperlipidemic (p<0.001) mice, but had no effect on the concentration of cystatin C in either controls or poloxamer 407-induced hyperlipidemic mice. Gadolinium 0-10 cystatin C Mus musculus 221-231 24914072-0 2015 Gadolinium-based compounds induce NLRP3-dependent IL-1beta production and peritoneal inflammation. Gadolinium 0-10 NLR family, pyrin domain containing 3 Mus musculus 34-39 24914072-0 2015 Gadolinium-based compounds induce NLRP3-dependent IL-1beta production and peritoneal inflammation. Gadolinium 0-10 interleukin 1 beta Mus musculus 50-58 25884277-0 2015 Heterogeneity in intratumoral regions with rapid gadolinium washout correlates with estrogen receptor status and nodal metastasis. Gadolinium 49-59 estrogen receptor 1 Homo sapiens 84-101 26568968-7 2015 For gadolinium-enhancing lesions alone, there was a significant association observed in GA and IFN subgroups, although the effect was more pronounced on IFN (HRGA = 0.57; p GA = 0.039 vs HRIFN = 0.41; p IFN = 0.022). Gadolinium 4-14 interferon alpha 1 Homo sapiens 95-98 26870745-3 2015 Traditionally, treatment effects for neurological conditions are evaluated by monitoring changes in intensities and/or volume of the ablation zone on post-treatment Gadolinium-contrast T1-w (Gd-T1) MRI. Gadolinium 165-175 transmembrane protein 165 Homo sapiens 191-196 26234669-0 2015 Gadolinium-complexed Abeta-binding contrast agents for MRI diagnosis of Alzheimer"s Disease. Gadolinium 0-10 amyloid beta (A4) precursor protein Mus musculus 21-26 26316749-5 2015 The use of GBI-10 aptamer in this liposomal system was intended to result in increased accumulation of gadolinium at the periphery of C6 glioma cells, where the targeting extracellular matrix protein tenascin-C is overexpressed. Gadolinium 103-113 tenascin C Homo sapiens 200-210 26140486-9 2015 CONCLUSIONS: Instillation of preservative-free normal saline into the thecal sac followed by intrathecal Gd infusion is a safe technique that may increase the detection of a CSF leak on MR myelography images in patients with SIH. Gadolinium 105-107 colony stimulating factor 2 Homo sapiens 174-177 26083726-8 2015 Our findings implicate Gd@C82(OH)22 as a novel HDAC inhibitor acting to increase RECK expression by suppressing the MTA1/HDAC1 co-repressor complex. Gadolinium 23-25 reversion inducing cysteine rich protein with kazal motifs Homo sapiens 81-85 26083726-8 2015 Our findings implicate Gd@C82(OH)22 as a novel HDAC inhibitor acting to increase RECK expression by suppressing the MTA1/HDAC1 co-repressor complex. Gadolinium 23-25 metastasis associated 1 Homo sapiens 116-120 26083726-8 2015 Our findings implicate Gd@C82(OH)22 as a novel HDAC inhibitor acting to increase RECK expression by suppressing the MTA1/HDAC1 co-repressor complex. Gadolinium 23-25 histone deacetylase 1 Homo sapiens 121-126 31973267-5 2015 SHMeQ[6] formed adducts of SHMeQ[6] with aqua complexes of lanthanide cations ([Ln(H2 O)8 ]3+ ); for SHMeQ[6]-Ln(NO3 )3 -CdCl2 -HCl systems (Ln=Gd-Lu), no solid crystals were obtained from systems that contained La, Ce, Pr, Nd, Sm, or Eu. Gadolinium 144-149 NBL1, DAN family BMP antagonist Homo sapiens 113-116 26203299-13 2015 CONCLUSIONS: These data show that IL-18 is significantly upregulated following GD-induced SE and localized primarily to endothelial cells in damaged brain vasculature. Gadolinium 79-81 interleukin 18 Rattus norvegicus 34-39 26203299-14 2015 IL-18 upregulation occurred following leukocyte/lymphocyte infiltration and in the absence of other IL-18-related cytokines, suggesting another function, potentially for angiogenesis related to GD-induced micro-hemorrhage formation. Gadolinium 194-196 interleukin 18 Rattus norvegicus 0-5 26022213-8 2015 We also report that this amino-coated Gd-nanoplatform, when subsequently conjugated with interleukin-13 peptide IL-13-Gd3N@C80(OH)x(NH2)y, exhibits enhanced targeting of U-251 GBM cell lines and can be effectively delivered intravenously in an orthotopic GBM mouse model. Gadolinium 38-40 interleukin 13 Homo sapiens 89-103 26022213-8 2015 We also report that this amino-coated Gd-nanoplatform, when subsequently conjugated with interleukin-13 peptide IL-13-Gd3N@C80(OH)x(NH2)y, exhibits enhanced targeting of U-251 GBM cell lines and can be effectively delivered intravenously in an orthotopic GBM mouse model. Gadolinium 38-40 interleukin 13 Homo sapiens 112-117 26055175-8 2015 The mean volume of an MDA-MB-231-BR-HER2 tumor was significantly larger compared to other models (F2,12 = 5.845, P < .05); interestingly, this model also had a significantly higher proportion of Gd-impermeable tumors (F2,12 = 22.18, P < .0001). Gadolinium 198-200 erb-b2 receptor tyrosine kinase 2 Mus musculus 36-40 26055175-9 2015 Ki67 staining indicated that Gd-impermeable tumors had significantly more proliferative nuclei compared to Gd-permeable tumors (t[24] = 2.389, P < .05) in the MDA-MB-231-BR-HER2 model. Gadolinium 29-31 antigen identified by monoclonal antibody Ki 67 Mus musculus 0-4 26055175-9 2015 Ki67 staining indicated that Gd-impermeable tumors had significantly more proliferative nuclei compared to Gd-permeable tumors (t[24] = 2.389, P < .05) in the MDA-MB-231-BR-HER2 model. Gadolinium 29-31 erb-b2 receptor tyrosine kinase 2 Mus musculus 176-180 25930178-2 2015 Epitaxial GDC (10 mol% Gd) films up to 1 mum in thickness are prepared using pulsed laser deposition on (100) yttria-stabilized zirconia single-crystal substrates and subjected to high-temperature annealing at 1300 C in air to induce microstructural modifications. Gadolinium 23-25 solute carrier family 25 member 16 Homo sapiens 10-13 25996983-6 2015 In essence, the scFv in gH substituted for gD-mediated activation and rendered a functional gD non-essential for entry via HER2. Gadolinium 43-45 immunglobulin heavy chain variable region Homo sapiens 16-20 24903851-1 2015 The emergence of an association between gadolinium-based contrast agents (GBCA) and the rare condition nephrogenic systemic fibrosis (NSF) led to a warning in 2006 from the Food and Drug Administration (FDA) restricting the use of the GBCAs to patients with an estimated glomerular filtration rate of >30 mL/min/1.73m(2) . Gadolinium 40-50 CD59 molecule (CD59 blood group) Homo sapiens 311-316 25867019-1 2015 A kind of Gd@C82 salt, Gd@C82/TBPA, was prepared through chemical oxidation. Gadolinium 10-12 transthyretin Homo sapiens 30-34 25867019-1 2015 A kind of Gd@C82 salt, Gd@C82/TBPA, was prepared through chemical oxidation. Gadolinium 23-25 transthyretin Homo sapiens 30-34 25565254-8 2015 Additionally, patients with gadolinium (gd+) lesions on brain MRI showed increased levels of IL-5 in blood (P = 0.03). Gadolinium 28-38 interleukin 5 Homo sapiens 93-97 25565254-8 2015 Additionally, patients with gadolinium (gd+) lesions on brain MRI showed increased levels of IL-5 in blood (P = 0.03). Gadolinium 40-42 interleukin 5 Homo sapiens 93-97 25494298-1 2015 PURPOSE: To test if MPO-Gd, a gadolinium-based magnetic resonance (MR) imaging probe that is sensitive and specific for the proinflammatory and oxidative enzyme myeloperoxidase (MPO), which is secreted by certain inflammatory cells, is more sensitive than diethylenetriaminepentaacetic acid (DTPA)-Gd in revealing early subclinical and chronic disease activity in the brain in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Gadolinium 30-40 myeloperoxidase Mus musculus 20-23 25494298-1 2015 PURPOSE: To test if MPO-Gd, a gadolinium-based magnetic resonance (MR) imaging probe that is sensitive and specific for the proinflammatory and oxidative enzyme myeloperoxidase (MPO), which is secreted by certain inflammatory cells, is more sensitive than diethylenetriaminepentaacetic acid (DTPA)-Gd in revealing early subclinical and chronic disease activity in the brain in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Gadolinium 30-40 myeloperoxidase Mus musculus 161-176 25494298-1 2015 PURPOSE: To test if MPO-Gd, a gadolinium-based magnetic resonance (MR) imaging probe that is sensitive and specific for the proinflammatory and oxidative enzyme myeloperoxidase (MPO), which is secreted by certain inflammatory cells, is more sensitive than diethylenetriaminepentaacetic acid (DTPA)-Gd in revealing early subclinical and chronic disease activity in the brain in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Gadolinium 30-40 myeloperoxidase Mus musculus 178-181 25486924-0 2015 Analysis of gadolinium-based contrast agents in tap water with a new hydrophilic interaction chromatography (ZIC-cHILIC) hyphenated with inductively coupled plasma mass spectrometry. Gadolinium 12-22 nuclear RNA export factor 1 Homo sapiens 48-51 25906297-1 2015 The report by Pulli et al ( 1 ) provides good preclinical evidence that MPO-Gd, a gadolinium-based magnetic resonance (MR) imaging probe for the enzyme myeloperoxidase (MPO), might be a more sensitive contrast agent for the detection of multiple sclerosis (MS) and may mark a pathologically specific proinflammatory component of the disease that might also provide the basis for novel therapies. Gadolinium 82-92 myeloperoxidase Homo sapiens 72-75 25906297-1 2015 The report by Pulli et al ( 1 ) provides good preclinical evidence that MPO-Gd, a gadolinium-based magnetic resonance (MR) imaging probe for the enzyme myeloperoxidase (MPO), might be a more sensitive contrast agent for the detection of multiple sclerosis (MS) and may mark a pathologically specific proinflammatory component of the disease that might also provide the basis for novel therapies. Gadolinium 82-92 myeloperoxidase Homo sapiens 152-167 25906297-1 2015 The report by Pulli et al ( 1 ) provides good preclinical evidence that MPO-Gd, a gadolinium-based magnetic resonance (MR) imaging probe for the enzyme myeloperoxidase (MPO), might be a more sensitive contrast agent for the detection of multiple sclerosis (MS) and may mark a pathologically specific proinflammatory component of the disease that might also provide the basis for novel therapies. Gadolinium 82-92 myeloperoxidase Homo sapiens 169-172 25731596-0 2015 Discrete {Gd(III)4M} (M = Gd(III) or Co(II)) pentanuclear complexes: a new class of metal-organophosphate molecular coolers. Gadolinium 10-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 37-43 25678124-4 2015 Doping lanthanide ions, i.e., europium (Eu) and gadolinium (Gd) ions, into an MSN structure (EuGd-MSNs) imparts fluorescence and magnetism to the nanostructure that can be used to develop magnetic resonance imaging (MRI) and biological fluorescence tools. Gadolinium 48-58 moesin Homo sapiens 78-81 25678124-4 2015 Doping lanthanide ions, i.e., europium (Eu) and gadolinium (Gd) ions, into an MSN structure (EuGd-MSNs) imparts fluorescence and magnetism to the nanostructure that can be used to develop magnetic resonance imaging (MRI) and biological fluorescence tools. Gadolinium 60-62 moesin Homo sapiens 78-81 25708615-7 2015 Prominent gadolinium-enhanced cerebral lesions or meninges were linked with continued treatment at the last followup encounter (OR 2.28). Gadolinium 10-20 olfactory receptor family 3 subfamily A member 2 Homo sapiens 128-135 25486924-1 2015 Hydrophilic interaction chromatography (HILIC) coupled with inductively coupled plasma mass spectrometry (ICP-MS) were optimised for the direct determination of gadolinium-based contrast agents in tap water. Gadolinium 161-171 nuclear RNA export factor 1 Homo sapiens 197-200 25486924-5 2015 With the speciation method described, tap water samples from the area of Berlin were analysed and for the first time, three Gd species, Gd-BT-DO3A, Gd-DOTA and Gd-BOPTA, were found in tap water samples at concentrations of about 10-20 ng Gd per litre. Gadolinium 124-126 nuclear RNA export factor 1 Homo sapiens 184-187 24753465-3 2015 Our objective was therefore to explore whether ICAM-1 expression can be visualized in vivo during EAE with magnetic resonance imaging (MRI) using micron-sized particles of iron oxide (MPIO), and to compare accumulation profiles of targeted and untargeted MPIO, and a gadolinium-containing agent. Gadolinium 267-277 intercellular adhesion molecule 1 Mus musculus 47-53 24990854-6 2015 In a subset of patients (MRI cohort), delayed-release DMF BID and TID reduced the mean number of new or enlarging T2-hyperintense lesions by 80% and 81%, gadolinium-enhancing lesion activity by 92% and 92%, and mean number of new non-enhancing T1-hypointense lesions by 68% and 70% (all p < 0.0001 versus placebo). Gadolinium 154-164 BH3 interacting domain death agonist Homo sapiens 58-61 24687204-11 2015 Activation of CaR by putrescine and gadolinium influences the contractile responsiveness of isolated cardiomyocytes. Gadolinium 36-46 calcium-sensing receptor Rattus norvegicus 14-17 25591890-7 2015 The present findings strongly suggest that t(he main reason for realization of the Tc >50 K observed in RE-1111 compounds (RE: Pr, Sm, and Gd) at ambient pressure is the merging of SC1 and SC2. Gadolinium 142-144 transcription factor 19 Homo sapiens 184-187 25591890-7 2015 The present findings strongly suggest that t(he main reason for realization of the Tc >50 K observed in RE-1111 compounds (RE: Pr, Sm, and Gd) at ambient pressure is the merging of SC1 and SC2. Gadolinium 142-144 trans-2,3-enoyl-CoA reductase Homo sapiens 192-195 25677550-8 2015 Gadolinium blocked the elevation of [Ca(2+)]s induced by focal mechanical stress and also attenuated accumulation of TRPV2. Gadolinium 0-10 transient receptor potential cation channel subfamily V member 2 Homo sapiens 117-122 25750916-5 2015 In a subset of patients (MRI cohort), DMF BID and TID reduced the mean number of new/enlarging T2-hyperintense lesions by 78% and 73%, gadolinium-enhancing lesion activity by 83% and 70%, and mean number of new nonenhancing T1-hypointense lesions by 65% and 64% (all P < 0.0001 vs. placebo). Gadolinium 135-145 BH3 interacting domain death agonist Homo sapiens 42-45 25462350-6 2015 Additional study indicated that tetherin likely physically interacted with gB, gD, gH and gL. Gadolinium 79-81 bone marrow stromal cell antigen 2 Homo sapiens 32-40 25273534-2 2015 We report a motion-sensitized driven-equilibrium MR imaging approach for the detection of a myeloperoxidase activity-specific gadolinium-containing imaging agent in experimental aneurysm models, which compensates for irregular blood flow, enabling vascular wall imaging in the aneurysm. Gadolinium 126-136 myeloperoxidase Oryctolagus cuniculus 92-107 25429349-3 2014 Here we employ a self-assembly approach and develop a caspase-3/7 activatable Gd-based MRI probe for monitoring tumor apoptosis in mice. Gadolinium 78-80 caspase 3 Mus musculus 54-63 25242631-0 2014 High CD6 and low chemokine receptor expression on peripheral blood lymphocytes correlates with MRI gadolinium enhancement in MS. Gadolinium 99-109 CD6 molecule Homo sapiens 5-8 25242631-0 2014 High CD6 and low chemokine receptor expression on peripheral blood lymphocytes correlates with MRI gadolinium enhancement in MS. Gadolinium 99-109 C-X-C motif chemokine receptor 4 Homo sapiens 17-35 25499394-5 2014 Three days after PET/CT, all mice received an intravenous administration of 0.2 mmol/kg body weight of a gadolinium-based elastin-binding contrast agent to assess plaque burden and vessel wall remodeling. Gadolinium 105-115 elastin Mus musculus 122-129 25499394-8 2014 Higher gadolinium-based elastin-binding contrast agent uptake was also detected in the aortic arch of ApoE(-/-) compared to WT mice using R(1) maps (R(1) = 1.47 +- 0.06 s(-1) vs. 0.92 +- 0.05 s(-1); P <0.001). Gadolinium 7-17 elastin Mus musculus 24-31 25499394-8 2014 Higher gadolinium-based elastin-binding contrast agent uptake was also detected in the aortic arch of ApoE(-/-) compared to WT mice using R(1) maps (R(1) = 1.47 +- 0.06 s(-1) vs. 0.92 +- 0.05 s(-1); P <0.001). Gadolinium 7-17 apolipoprotein E Mus musculus 102-106 25376186-0 2014 Monitoring phospholipase A2 activity with Gd-encapsulated phospholipid liposomes. Gadolinium 42-44 phospholipase A2 group IB Homo sapiens 11-27 25376186-7 2014 However, when the phospholipids within the liposomal membrane were hydrolyzed by PLA2, encapsulated Gd was released into bulk solution, resulting in a measureable change in the T1-relaxation time. Gadolinium 100-102 phospholipase A2 group IB Homo sapiens 81-85 25169024-3 2014 The dc magnetic studies show that ferromagnetic metal-radical interactions take place in these hetero-tri-spin chain complexes, these and the next-neighbor interactions have been quantified for the Gd derivatives. Gadolinium 198-200 spindlin 1 Homo sapiens 106-110 25457841-4 2014 Increased levels of CCL22, CXCL10 and sCD40L characterized relapsing-remitting MS patients with the presence of gadolinium-enhancing lesions; decreased CCL2 and increased CXCL1 and CCL5 were typical of relapsing-remitting MS patients irrespectively of the presence of gadolinium-enhancing lesions. Gadolinium 112-122 C-C motif chemokine ligand 2 Homo sapiens 20-24 25482498-4 2014 Gd therefore is an interesting candidate for spin injection into monolayer MoS2. Gadolinium 0-2 spindlin 1 Homo sapiens 45-49 25297998-7 2014 The gD-positive and gD-negative PRV capsids were both capable of trafficking along microtubules in vitro; however, motile gD-positive particles were less numerous and their trafficking was more sensitive to the inhibitory effects of Vps4A-EQ. We discuss our data in the context of microtubule-mediated trafficking of naked and enveloped alphaherpesvirus capsids. Gadolinium 4-6 vacuolar protein sorting 4 homolog A Homo sapiens 233-238 25059192-1 2014 Gadolinium complexed with naturally occurring, negatively charged humic substances (humic and fulvic acids) was collected from 500 mL of sample solution onto a column packed with 150 mg of a strongly basic anion-exchanger (QAE-Sephadex A-25). Gadolinium 0-10 immunoglobulin kappa variable 1-22 (pseudogene) Homo sapiens 236-240 24829362-5 2014 The indexed LV mass and measures of replacement fibrosis (late gadolinium enhancement) were associated with cTnI concentrations independent of age, sex, coronary artery disease, aortic stenosis severity, and diastolic function. Gadolinium 63-73 troponin I3, cardiac type Homo sapiens 108-112 25048859-10 2014 In addition, bosentan inhibited Gd-induced phosphorylation of ERK and Akt in hMSC. Gadolinium 32-34 mitogen-activated protein kinase 1 Homo sapiens 62-65 25048859-10 2014 In addition, bosentan inhibited Gd-induced phosphorylation of ERK and Akt in hMSC. Gadolinium 32-34 AKT serine/threonine kinase 1 Homo sapiens 70-73 25048859-8 2014 ET-1 and ETR-A expression in hMSC treated with Gd were elevated. Gadolinium 47-49 endothelin 1 Homo sapiens 0-4 25048859-8 2014 ET-1 and ETR-A expression in hMSC treated with Gd were elevated. Gadolinium 47-49 endothelin receptor type A Homo sapiens 9-14 24814820-4 2014 In this study, we test the feasibility of quantifying aortic wall elastin content using MRI with a gadolinium-based elastin-specific magnetic resonance contrast agent in Fbn1(C1039G/+) mice. Gadolinium 99-109 elastin Mus musculus 66-73 24123370-2 2014 Gadofosveset is a US FDA approved small molecule Gadolinium (Gd) chelate (957 Da) which reversibly binds serum albumin and temporally behaves as a macromolecule. Gadolinium 49-59 albumin Mus musculus 105-118 24123370-2 2014 Gadofosveset is a US FDA approved small molecule Gadolinium (Gd) chelate (957 Da) which reversibly binds serum albumin and temporally behaves as a macromolecule. Gadolinium 61-63 albumin Mus musculus 105-118 24571714-5 2014 RESULTS: Patients in clinical relapse and patients with nonsymptomatic gadolinium enhancing lesions had high levels of MBP and NFL, indicating ongoing damage to oligodendrocytes and axons. Gadolinium 71-81 myelin basic protein Homo sapiens 119-122 24571714-5 2014 RESULTS: Patients in clinical relapse and patients with nonsymptomatic gadolinium enhancing lesions had high levels of MBP and NFL, indicating ongoing damage to oligodendrocytes and axons. Gadolinium 71-81 neurofilament light chain Homo sapiens 127-130 25037060-0 2014 Gadolinium promoted proliferation in mouse embryo fibroblast NIH3T3 cells through Rac and PI3K/Akt signaling pathways. Gadolinium 0-10 thymoma viral proto-oncogene 1 Mus musculus 82-85 25037060-0 2014 Gadolinium promoted proliferation in mouse embryo fibroblast NIH3T3 cells through Rac and PI3K/Akt signaling pathways. Gadolinium 0-10 thymoma viral proto-oncogene 1 Mus musculus 95-98 25037060-4 2014 The results showed that intervention with the Rac inhibitor NSC23766 abrogated Gd-promoted proliferation. Gadolinium 79-81 thymoma viral proto-oncogene 1 Mus musculus 46-49 25037060-5 2014 The levels of active Rac1 significantly increased in Gd-treated cells detected by pull-down assays. Gadolinium 53-55 Rac family small GTPase 1 Mus musculus 21-25 24969589-3 2014 We have investigated the weak self-association of human growth hormone (hGH, KD = 0.90 +- 0.03 mM) at neutral pH by the paramagnetic relaxation enhancement (PRE) of the amide protons induced by the soluble paramagnetic relaxation agent, gadodiamide (Gd(DTPA-BMA)). Gadolinium 250-252 growth hormone 1 Homo sapiens 56-70 24988410-3 2014 Elevated S100B matches the clinical presence of indices of BBBD (gadolinium enhancement or albumin coefficient). Gadolinium 65-75 S100 calcium binding protein B Homo sapiens 9-14 24699093-8 2014 For the MS group, significant changes were observed pre- and post-gadolinium in intracranial volume (-13 mL, P < .005) and cerebrospinal fluid volume (-16 mL, P < .005) and the remaining, unclassified non-WM/GM/CSF tissue volume within the intracranial volume (+8 mL, P < .05). Gadolinium 66-76 colony stimulating factor 2 Homo sapiens 217-220 24814820-4 2014 In this study, we test the feasibility of quantifying aortic wall elastin content using MRI with a gadolinium-based elastin-specific magnetic resonance contrast agent in Fbn1(C1039G/+) mice. Gadolinium 99-109 elastin Mus musculus 116-123 24814820-4 2014 In this study, we test the feasibility of quantifying aortic wall elastin content using MRI with a gadolinium-based elastin-specific magnetic resonance contrast agent in Fbn1(C1039G/+) mice. Gadolinium 99-109 fibrillin 1 Mus musculus 170-174 24814820-7 2014 Post-elastin-specific magnetic resonance contrast agent R1 values correlated with ascending aortic wall gadolinium content directly measured by inductively coupled mass spectroscopy (P=0.006). Gadolinium 104-114 elastin Mus musculus 5-12 24814820-8 2014 CONCLUSIONS: Herein, we demonstrate that MRI with elastin-specific magnetic resonance contrast agent accurately measures elastin bound gadolinium within the aortic wall and detects a decrease in aortic wall elastin in Marfan mice compared with wild-type controls. Gadolinium 135-145 elastin Mus musculus 50-57 24814820-8 2014 CONCLUSIONS: Herein, we demonstrate that MRI with elastin-specific magnetic resonance contrast agent accurately measures elastin bound gadolinium within the aortic wall and detects a decrease in aortic wall elastin in Marfan mice compared with wild-type controls. Gadolinium 135-145 elastin Mus musculus 121-128 24814820-8 2014 CONCLUSIONS: Herein, we demonstrate that MRI with elastin-specific magnetic resonance contrast agent accurately measures elastin bound gadolinium within the aortic wall and detects a decrease in aortic wall elastin in Marfan mice compared with wild-type controls. Gadolinium 135-145 elastin Mus musculus 121-128 25152034-6 2014 Pretreatment with gadolinium inhibited the activation of macrophages and the induction of iNOS in intestinal resident macrophages, and restored the number of KIT-positive cells and intestinal contractions. Gadolinium 18-28 nitric oxide synthase 2, inducible Mus musculus 90-94 24789783-7 2014 Importantly, IgGs from the majority of gD2-immunized subjects competed for gD binding with four antigenically distinct virus-neutralizing MAbs (MC2, MC5, MC23, and DL11). Gadolinium 39-41 melanocortin 5 receptor Homo sapiens 144-147 24627717-4 2014 The interference for gadolinium contrast agents include negative bias in calcium assessment with ortho-cresolphthalein colorimetric assays and occasional positive bias using some Arsenazo reagents, negative bias in measurement of angiotensin converting enzyme (ACE) and zinc (colorimetric assay), as well as positive bias in creatinine (Jaffe reaction), total iron binding capacity (TIBC, ferrozine method), magnesium (calmagite reagent) and selenium (mass spectrometry) measurement. Gadolinium 21-31 angiotensin I converting enzyme Homo sapiens 261-264 24407461-0 2014 Binding of a dimeric manganese porphyrin to serum albumin: towards a gadolinium-free blood-pool T1 MRI contrast agent. Gadolinium 69-79 albumin Rattus norvegicus 44-57 24407461-1 2014 As the first clinically approved gadolinium-based blood-pool MRI contrast agent, gadofosveset was designed to bind to human serum albumin (HSA) reversibly, extending the circulation time in the bloodstream. Gadolinium 33-43 albumin Rattus norvegicus 124-137 24738346-3 2014 In the xenograft mouse model, we found that metallofullerol Gd@C82(OH)22 can not only reduced the macrophage density in the tumor tissue, but also decreased the expression of matrix metalloproteinase-9 produced by this kind of cell. Gadolinium 60-62 matrix metallopeptidase 9 Mus musculus 175-201 24758941-8 2014 Surface electrostatics uniquely determines the initial adsorption of Gd@C82(OH)22 on MMP-2, and then its further location of the most favorable binding site(s). Gadolinium 69-71 matrix metallopeptidase 2 Homo sapiens 85-90 24503060-3 2014 Exposure of Cx43-expressing Xenopus laevis oocytes to divalent cation free solution induced a gadolinium-sensitive uptake of the fluorescent dye ethidium. Gadolinium 94-104 gap junction protein alpha 1 S homeolog Xenopus laevis 12-16 24582827-0 2014 Brain gadolinium enhancement along the ventricular and leptomeningeal regions in patients with aquaporin-4 antibodies in cerebral spinal fluid. Gadolinium 6-16 aquaporin 4 Homo sapiens 95-106 24593782-5 2014 A significant increase in V-ATPase activity was also observed when CaSR was stimulated with agonists such as 300 mumol L(-1) Gd(3+) and 200 mumol L(-1) neomycin, both in the cortex and outer medulla. Gadolinium 125-127 ATPase, H+ transporting, lysosomal V0 subunit D2 Mus musculus 26-34 24593782-5 2014 A significant increase in V-ATPase activity was also observed when CaSR was stimulated with agonists such as 300 mumol L(-1) Gd(3+) and 200 mumol L(-1) neomycin, both in the cortex and outer medulla. Gadolinium 125-127 calcium-sensing receptor Mus musculus 67-71 24375408-10 2014 The TRPML currents were inhibited by trivalent cations Fe(3+), La(3+), and Gd(3+). Gadolinium 75-77 Transient receptor potential cation channel, mucolipin Drosophila melanogaster 4-9 24336144-5 2014 RESULTS: Patients with MRI evidence of poor response to IFN-beta treatment as defined by either >=2 new hyperintense T2 lesions or new gadolinium-enhancing lesions had significantly increased risk of both future relapses and progression as defined by the Expanded Disability Status Scale. Gadolinium 138-148 interferon beta 1 Homo sapiens 56-64 24778878-7 2014 Gadolinium-enhanced MRI was performed on 312 of 837 patients, including 23 with severe renal failure (GFR < 30 mL/min/1.73 cm(2)) and 289 with GFR > 30. Gadolinium 0-10 CD59 molecule (CD59 blood group) Homo sapiens 117-122 24111526-1 2014 The gadolinium-based contrast agent (GdBCA) Omniscan activates human macrophages through Toll-like receptor (TLR)-4 and TLR-7 signalling. Gadolinium 4-14 toll like receptor 4 Homo sapiens 89-115 24111526-1 2014 The gadolinium-based contrast agent (GdBCA) Omniscan activates human macrophages through Toll-like receptor (TLR)-4 and TLR-7 signalling. Gadolinium 4-14 toll like receptor 7 Homo sapiens 120-125 24135848-6 2014 The univariate and multivariate analysis showed that greater preoperative tumor volume in T1 gadolinium enhanced sequences, was the only variable with statistical signification (p < 0.001) for increased rate of non-local recurrences, although patients with MGMT methylation and complete resection of enhancing tumor presented non-local recurrences more frequently. Gadolinium 93-103 O-6-methylguanine-DNA methyltransferase Homo sapiens 260-264 23838997-1 2013 This study aims to investigate gadolinium-based nanoparticles (Gd-HNP) for in vitro labeling of human plasmacytoid dendritic cells (HuPDC) to allow for in vivo tracking and HuPDC quantifying using magnetic resonance imaging (MRI) following parenteral injection. Gadolinium 31-41 kallikrein related peptidase 8 Homo sapiens 66-69 23744881-3 2014 In the 12-month-old male offspring of pregnant rat dams exposed to 11.5% atmospheric oxygen from gestational day (gd) 15 to gd 21, nonfasting glucose was lower in association with decreased hepatic G6Pase messenger RNA and protein levels. Gadolinium 114-116 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 198-204 24071064-4 2013 RESULTS: Patients with diffuse leptomeningeal gadolinium enhancement on MRI had significantly higher cell counts (>=50 cells/mul in 80%), total protein (>=200 mg/dl in 80%), CSF/serum albumin quotients (Q(Alb), >=30 in 80%), and lactate (>=30 mg/dl in 70%), but significantly lower glucose levels (<=40 mg/dl in 67%) than patients without leptomeningeal enhancement. Gadolinium 46-56 albumin Homo sapiens 211-214 24307601-6 2013 Maximum DEF values on the central transverse line, within the tumour, for Fe2O3, Ag, Gd, Pt and Au nanoparticles with 30 mg/ml concentration were 1.27, 1.15, 1.14, 1.32, 1.79, respectively. Gadolinium 85-87 UTP25 small subunit processome component Homo sapiens 8-11 24289827-9 2013 Nonetheless, pretreatment with an anti-NUCB2/nesfatin-1 antibody in the Arc further increased the firing rate of most of the ghrelin-responsive GD-excitatory neurons and decreased the ghrelin-responsive GD-inhibitory neurons following electrical stimulation of the PVN. Gadolinium 144-146 nucleobindin 2 Rattus norvegicus 39-44 24289827-9 2013 Nonetheless, pretreatment with an anti-NUCB2/nesfatin-1 antibody in the Arc further increased the firing rate of most of the ghrelin-responsive GD-excitatory neurons and decreased the ghrelin-responsive GD-inhibitory neurons following electrical stimulation of the PVN. Gadolinium 144-146 nucleobindin 2 Rattus norvegicus 45-55 24289827-9 2013 Nonetheless, pretreatment with an anti-NUCB2/nesfatin-1 antibody in the Arc further increased the firing rate of most of the ghrelin-responsive GD-excitatory neurons and decreased the ghrelin-responsive GD-inhibitory neurons following electrical stimulation of the PVN. Gadolinium 144-146 ghrelin and obestatin prepropeptide Rattus norvegicus 125-132 24289827-9 2013 Nonetheless, pretreatment with an anti-NUCB2/nesfatin-1 antibody in the Arc further increased the firing rate of most of the ghrelin-responsive GD-excitatory neurons and decreased the ghrelin-responsive GD-inhibitory neurons following electrical stimulation of the PVN. Gadolinium 203-205 nucleobindin 2 Rattus norvegicus 39-44 24289827-9 2013 Nonetheless, pretreatment with an anti-NUCB2/nesfatin-1 antibody in the Arc further increased the firing rate of most of the ghrelin-responsive GD-excitatory neurons and decreased the ghrelin-responsive GD-inhibitory neurons following electrical stimulation of the PVN. Gadolinium 203-205 nucleobindin 2 Rattus norvegicus 45-55 24080112-0 2013 Single cell tracking of gadolinium labeled CD4+ T cells by laser ablation inductively coupled plasma mass spectrometry. Gadolinium 24-34 CD4 molecule Homo sapiens 43-46 24081881-7 2013 Protein levels and the ROS-producing activity of Nox4 were increased in the endoplasmic reticulum (ER), but not in mitochondria, in response to GD. Gadolinium 144-146 NADPH oxidase 4 Mus musculus 49-53 24081881-8 2013 Selective knockdown of Nox4, but not Nox2, or selective reduction of ROS in the ER with ER-targeted catalase, but not mitochondria-targeted perioxiredoxin 3, abrogated GD-induced autophagy. Gadolinium 168-170 NADPH oxidase 4 Mus musculus 23-27 24013548-8 2013 Exposure of MDCK cells maintained in low-Ca(2+) conditions to the CaSR agonists neomycin, Gd(3+) or R-568 causes the transient relocation of the tight junction components ZO-1 and occludin to sites of cell-cell contact, while inducing no significant changes in the expression of mRNAs encoding junction-associated proteins. Gadolinium 90-92 calcium sensing receptor Canis lupus familiaris 66-70 24013548-8 2013 Exposure of MDCK cells maintained in low-Ca(2+) conditions to the CaSR agonists neomycin, Gd(3+) or R-568 causes the transient relocation of the tight junction components ZO-1 and occludin to sites of cell-cell contact, while inducing no significant changes in the expression of mRNAs encoding junction-associated proteins. Gadolinium 90-92 tight junction protein 1 Canis lupus familiaris 171-175 24013548-8 2013 Exposure of MDCK cells maintained in low-Ca(2+) conditions to the CaSR agonists neomycin, Gd(3+) or R-568 causes the transient relocation of the tight junction components ZO-1 and occludin to sites of cell-cell contact, while inducing no significant changes in the expression of mRNAs encoding junction-associated proteins. Gadolinium 90-92 occludin Canis lupus familiaris 180-188 24107491-7 2013 Seventy-two hours after positron emission tomography/computed tomography, all mice were scanned 2 hours after intravenous administration of 0.2 mmol/kg body weight of a gadolinium-based elastin-specific MR contrast agent. Gadolinium 169-179 elastin Mus musculus 186-193 24040783-6 2013 At 24 hours after MRI with gadolinium administration in the Gd-CIN group, the urinary KIM-1, IL-18 and Cys-C were significantly increased. Gadolinium 27-37 hepatitis A virus cellular receptor 1 Homo sapiens 86-91 24040783-6 2013 At 24 hours after MRI with gadolinium administration in the Gd-CIN group, the urinary KIM-1, IL-18 and Cys-C were significantly increased. Gadolinium 27-37 interleukin 18 Homo sapiens 93-98 24040783-6 2013 At 24 hours after MRI with gadolinium administration in the Gd-CIN group, the urinary KIM-1, IL-18 and Cys-C were significantly increased. Gadolinium 27-37 cystatin C Homo sapiens 103-108 24040783-7 2013 Logistic regression analysis showed that urinary KIM-1 and IL-18 at 24 hours after gadolinium injection were independent predictive markers of Gd-CIN. Gadolinium 83-93 hepatitis A virus cellular receptor 1 Homo sapiens 49-54 24040783-7 2013 Logistic regression analysis showed that urinary KIM-1 and IL-18 at 24 hours after gadolinium injection were independent predictive markers of Gd-CIN. Gadolinium 83-93 interleukin 18 Homo sapiens 59-64 24375901-7 2013 If the upper bound for the gadolinium concentration is 2 mM, the greatest maxCE is found for compounds with a r2/r1 ratio of 1.2 and an r1 relaxivity of 20.5 mM-1 s-1 at 3 T, 18 mM-1 s-1 at 7 T and 16.5 mM-1 s-1 at 9.4 T. For compounds that do not change their r1 relaxivity or r2 /r1 ratios, the necessary dose can be reduced by 10-15% owing to the improved background suppression at higher fields. Gadolinium 27-37 ribonucleotide reductase regulatory subunit M2 Homo sapiens 110-128 24078731-5 2013 RESULTS: Compared to the 40 with CAA, the 28 with ABRA were younger at diagnosis (p = 0.05), had less altered cognition (p = 0.02), fewer neurologic deficits (p = 0.02), and fewer intracranial hemorrhages (<0.001), but increased gadolinium leptomeningeal enhancement (p = 0.01) at presentation, and less mortality and disability at last follow-up (p < 0.001). Gadolinium 232-242 actin binding Rho activating protein Homo sapiens 50-54 23746480-3 2013 Levels of hs-cTnT and BNP were higher in 23 patients with late gadolinium enhancement than in 30 patients without it (p <0.01 for both). Gadolinium 63-73 troponin T2, cardiac type Homo sapiens 13-17 23867799-0 2013 Gadolinium contrast agent-induced CD163+ ferroportin+ osteogenic cells in nephrogenic systemic fibrosis. Gadolinium 0-10 CD163 molecule Homo sapiens 34-39 23867799-6 2013 Gadolinium contrast induced differentiation of human peripheral blood mononuclear cells into a unique cellular phenotype--CD163(+) cells expressing proteins involved in fibrosis and bone formation. Gadolinium 0-10 CD163 molecule Homo sapiens 122-127 23867799-9 2013 Gadolinium contrast-induced CD163(+)/ferroportin(+)/FGF23(+) cells with osteogenic potential may play a role in systemic fibrosis and ectopic ossification in nephrogenic systemic fibrosis. Gadolinium 0-10 CD163 molecule Homo sapiens 28-33 23867799-9 2013 Gadolinium contrast-induced CD163(+)/ferroportin(+)/FGF23(+) cells with osteogenic potential may play a role in systemic fibrosis and ectopic ossification in nephrogenic systemic fibrosis. Gadolinium 0-10 fibroblast growth factor 23 Homo sapiens 52-57 23863078-4 2013 On the basis of comparative MRI experiments, we have been able to demonstrate that these Gd-Tx micelles are able to target MC1R-expressing xenograft tumors in vitro and in vivo more effectively than various control systems, including untargeted or un-cross-linked Gd-Tx micelles. Gadolinium 89-91 melanocortin 1 receptor Mus musculus 123-127 23863078-4 2013 On the basis of comparative MRI experiments, we have been able to demonstrate that these Gd-Tx micelles are able to target MC1R-expressing xenograft tumors in vitro and in vivo more effectively than various control systems, including untargeted or un-cross-linked Gd-Tx micelles. Gadolinium 264-266 melanocortin 1 receptor Mus musculus 123-127 23746480-3 2013 Levels of hs-cTnT and BNP were higher in 23 patients with late gadolinium enhancement than in 30 patients without it (p <0.01 for both). Gadolinium 63-73 natriuretic peptide B Homo sapiens 22-25 23746480-4 2013 An hs-cTnT level >=0.007 ng/ml or a BNP level >=70 pg/ml had good diagnostic value for detecting late gadolinium enhancement, with sensitivity of 96% or specificity of 90% with the combination of these 2 biomarkers. Gadolinium 108-118 natriuretic peptide B Homo sapiens 39-42 23746480-5 2013 The extent of late gadolinium enhancement was correlated with BNP level (p <0.01) but not with hs-cTnT level in 23 patients with HC with late gadolinium enhancement. Gadolinium 19-29 natriuretic peptide B Homo sapiens 62-65 23746480-6 2013 The increase in the extent of late gadolinium enhancement was related to hs-cTnT level in 8 patients during 22 months of follow-up (p = 0.02). Gadolinium 35-45 troponin T2, cardiac type Homo sapiens 76-80 23613439-1 2013 The non-covalent interactions of gadolinium-based MRI contrast agents with macromolecules, such as human serum albumin (HSA), increase their efficacy. Gadolinium 33-43 albumin Homo sapiens 105-118 23901356-3 2013 VEGFR2 levels were assessed by intravenous administration of an anti-VEGFR2 probe (anti-VEGFR2-albumin-Gd (gadolinium)-DTPA (diethylene triamine penta acetic acid)-biotin) into C6 or RG2 glioma-bearing rats, and visualized with mMRI. Gadolinium 107-118 kinase insert domain receptor Rattus norvegicus 0-6 23901356-3 2013 VEGFR2 levels were assessed by intravenous administration of an anti-VEGFR2 probe (anti-VEGFR2-albumin-Gd (gadolinium)-DTPA (diethylene triamine penta acetic acid)-biotin) into C6 or RG2 glioma-bearing rats, and visualized with mMRI. Gadolinium 107-118 kinase insert domain receptor Rattus norvegicus 69-75 23901356-3 2013 VEGFR2 levels were assessed by intravenous administration of an anti-VEGFR2 probe (anti-VEGFR2-albumin-Gd (gadolinium)-DTPA (diethylene triamine penta acetic acid)-biotin) into C6 or RG2 glioma-bearing rats, and visualized with mMRI. Gadolinium 107-118 kinase insert domain receptor Rattus norvegicus 69-75 23324829-4 2013 Furthermore, the capability of CMR to perform tissue characterization and detect oedema, fat and fibrotic substrate, using late gadolinium enhanced images (LGE), can predict VT/SCD in both ischaemic and non-ischaemic cardiomyopathy. Gadolinium 128-138 stearoyl-CoA desaturase Homo sapiens 174-180 22811020-0 2013 Transferrin-coated gadolinium nanoparticles as MRI contrast agent. Gadolinium 19-29 transferrin Mus musculus 0-11 23730413-4 2013 We conjugated the SBK2 peptide to a gadolinium chelate [SBK2-Tris-(Gd-DOTA)3] to test whether the SBK2 probe could be developed as an MR molecular imaging probe. Gadolinium 36-46 SH3 domain binding kinase family member 2 Homo sapiens 56-60 23730413-4 2013 We conjugated the SBK2 peptide to a gadolinium chelate [SBK2-Tris-(Gd-DOTA)3] to test whether the SBK2 probe could be developed as an MR molecular imaging probe. Gadolinium 36-46 SH3 domain binding kinase family member 2 Homo sapiens 56-60 23700643-0 2004 Transferrin-coated gadolinium-labeled human serum albumin nanoparticles It is necessary to use small molecule contrast agents (CAs) to generate a good contrast in images produced with magnetic resonance imaging (MRI) for the proper diagnosis and monitoring of diseases. Gadolinium 19-29 transferrin Mus musculus 0-11 23700643-0 2004 Transferrin-coated gadolinium-labeled human serum albumin nanoparticles It is necessary to use small molecule contrast agents (CAs) to generate a good contrast in images produced with magnetic resonance imaging (MRI) for the proper diagnosis and monitoring of diseases. Gadolinium 19-29 albumin Mus musculus 44-57 23470714-7 2013 The involvement of TRPV1 and TRPV4 in gentamicin trafficking of hair cells was confirmed by exogenous calcium treatment and TRPV inhibitors, including gadolinium and ruthenium red, which resulted in markedly inhibited GTTR uptake and gentamicin-induced hair cell damage in rodent and zebrafish ototoxic model systems. Gadolinium 151-161 transient receptor potential cation channel, subfamily V, member 1 Danio rerio 19-24 23403698-10 2013 To a certain extent, Apelin-13 inhibited GD-induced cardiomyocyte autophagy, which may be related in part to the activation of the PI3K/Akt/mTOR signaling pathway. Gadolinium 41-43 AKT serine/threonine kinase 1 Rattus norvegicus 136-139 23403698-10 2013 To a certain extent, Apelin-13 inhibited GD-induced cardiomyocyte autophagy, which may be related in part to the activation of the PI3K/Akt/mTOR signaling pathway. Gadolinium 41-43 mechanistic target of rapamycin kinase Rattus norvegicus 140-144 23192655-4 2013 We showed that mAb-HSA-GD was able to detect the HSA Tyr 411 OP adduct at a low level (i.e., human blood plasma treated with 180 nM GD) that could not be detected by mass spectrometry. Gadolinium 23-25 albumin Homo sapiens 19-22 23391162-1 2013 The Gd(III) complex of DO3A-N-alpha-aminopropionate, Gd(DOTAla), was used to generate a small library of putative MRI probes targeted to human serum albumin (HSA). Gadolinium 4-6 albumin Homo sapiens 143-156 23334397-0 2013 Hybrid gold-gadolinium nanoclusters for tumor-targeted NIRF/CT/MRI triple-modal imaging in vivo. Gadolinium 12-22 interleukin 17B Homo sapiens 55-59 23334397-2 2013 In this study, we prepared hybrid gold-gadolinium nanoclusters (NCs), which are ultrasmall, stable, biocompatible, and suitable for triple-modal NIRF/CT/MRI imaging. Gadolinium 39-49 interleukin 17B Homo sapiens 145-149 23218930-6 2013 WT and PTP1B KO cultures displayed similar pharmacological sensitivities towards the SOCE inhibitors gadolinium and 2-aminoethoxydiphenyl borate, as well as the tyrosine kinase inhibitor Ag126 indicating an augmentation of native SOCCs by PTP1B. Gadolinium 101-111 protein tyrosine phosphatase, non-receptor type 1 Mus musculus 7-12 23192655-4 2013 We showed that mAb-HSA-GD was able to detect the HSA Tyr 411 OP adduct at a low level (i.e., human blood plasma treated with 180 nM GD) that could not be detected by mass spectrometry. Gadolinium 23-25 albumin Homo sapiens 49-52 23192655-5 2013 mAb-HSA-GD and mAb-HSA-VX showed an extremely low-level detection of GD adducted to HSA (on the order of picograms). Gadolinium 8-10 albumin Homo sapiens 4-7 23222658-9 2013 Noxious GD induced p-p38 in DRG neurons with a peak at 2 min after GD. Gadolinium 8-10 mitogen activated protein kinase 14 Rattus norvegicus 21-24 23132739-5 2013 Knocking down endogenous Numb expression via siRNA protected PC12 cells from GD-induced apoptosis, whereas Numb overexpression sensitized PC12 cells to GD-induced apoptosis. Gadolinium 77-79 NUMB, endocytic adaptor protein Rattus norvegicus 25-29 23222658-9 2013 Noxious GD induced p-p38 in DRG neurons with a peak at 2 min after GD. Gadolinium 67-69 mitogen activated protein kinase 14 Rattus norvegicus 21-24 23222658-11 2013 Intrathecal administration of the p38 inhibitor, SB203580, attenuated the electromyographic response to noxious GD. Gadolinium 112-114 mitogen activated protein kinase 14 Rattus norvegicus 34-37 22800579-3 2012 The LPD formulation containing the liposome with 15% Gd-chelated lipid displayed optimal peptide-targeted, transfection efficiency. Gadolinium 53-55 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 4-7 23378325-8 2013 In the IM IFNbeta-1a group, persistent disease activity predicted severe EDSS worsening: gadolinium-enhancing lesions (odds ratio [OR], 8.96; p < 0.001); relapses (OR, 4.44; p = 0.010); and new T2 lesions (OR, 2.90; p = 0.080). Gadolinium 89-99 interferon beta 1 Homo sapiens 10-17 23378325-11 2013 Particular attention should be paid to gadolinium-enhancing lesions on IFNbeta therapy, as their presence strongly correlates with severe disability 15 years later. Gadolinium 39-49 interferon beta 1 Homo sapiens 71-78 22847020-14 2013 The goal of targeting tumor antigens highly expressed on glioblastoma cancer stem cells is supported by the observation of decreased or absent CD133 expression in the recurrent areas of gadolinium-enhanced tumors. Gadolinium 186-196 prominin 1 Homo sapiens 143-148 23383067-10 2013 Native leak currents without expressing NALCN genes in HEK-293T cells are NMDG(+) impermeant and blockable with 10 microM Gd(3+) ions and are indistinguishable from the hallmark currents ascribed to mammalian NALCN currents expressed in vitro by Lu et al. Gadolinium 122-124 sodium leak channel, non-selective Homo sapiens 40-45 22849307-9 2012 CONCLUSIONS: Mixed neutron beam irradiation plus Auger electron irradiation from gadolinium neutron capture is a moderately high LET modality that kills U87 cells without the induction of necrosis and with progression of autophagy to an extreme state. Gadolinium 81-91 small nucleolar RNA, C/D box 87 Homo sapiens 153-156 22906607-1 2012 A d-f heteronuclear complex (Ir-Gd) by coupling an iridium(III) complex to a macrocycle-based gadolinium complex has been developed as as a dual-mode bioimaging probe for luminescence imaging and magnetic resonance imaging (MRI). Gadolinium 94-104 interferon gamma inducible protein 47 Mus musculus 29-34 23109394-2 2013 In this study the intrinsic ability of two differently sized gadolinium-based contrast agents to enhance atherosclerotic plaques in ApoE(-/-) mice was evaluated with MRI. Gadolinium 61-71 apolipoprotein E Mus musculus 132-136 23860467-7 2013 CONCLUSION: We found a strong association between serum anti-AQP4 antibody positivity and lesional gadolinium enhancement in patients with clinically definite NMO. Gadolinium 99-109 aquaporin 4 Homo sapiens 61-65 24124363-0 2013 Preparation and characterization of gadolinium-loaded PLGA particles surface modified with RGDS for the detection of thrombus. Gadolinium 36-46 ral guanine nucleotide dissociation stimulator Homo sapiens 91-95 24124363-3 2013 In this study, we explore the preparation and characterization of gadolinium (Gd)-loaded poly (lactic-co-glycolic acid) (PLGA) particles surface modified with the Arg-Gly-Asp-Ser (RGDS) peptide for the detection of thrombus. Gadolinium 66-76 ral guanine nucleotide dissociation stimulator Homo sapiens 180-184 24124363-3 2013 In this study, we explore the preparation and characterization of gadolinium (Gd)-loaded poly (lactic-co-glycolic acid) (PLGA) particles surface modified with the Arg-Gly-Asp-Ser (RGDS) peptide for the detection of thrombus. Gadolinium 78-80 ral guanine nucleotide dissociation stimulator Homo sapiens 180-184 24124363-9 2013 The high electron density of the Gd-loaded particles and a translucent film around the particles coated with the CS and CS-RGDS films could be observed by transmission electron microscopy. Gadolinium 33-35 ral guanine nucleotide dissociation stimulator Homo sapiens 123-127 23147086-1 2012 The large cryogenic magnetocaloric effect of a 3D oxydiacetate-bridged gadolinium-manganese MOF material, [Mn(H(2)O)(6)][MnGd(oda)(3)](2) 6H(2)O (1), was evaluated by magnetization and heat capacity measurements. Gadolinium 71-81 lysine acetyltransferase 8 Homo sapiens 92-95 22492130-6 2012 RESULTS: IM IFNbeta-1a significantly decreased the median number of gadolinium-enhanced lesions from 2.5 to 0.3 (p < 0.0001) compared with pre-treatment values. Gadolinium 68-78 interferon beta 1 Homo sapiens 12-19 23112188-7 2012 We found that MSL10 formed a channel with a moderate preference for anions, which was modulated by strongly positive and negative membrane potentials, and was reversibly inhibited by gadolinium, a known inhibitor of mechanosensitive channels. Gadolinium 183-193 mechanosensitive channel of small conductance-like 10 Arabidopsis thaliana 14-19 22915762-2 2012 It is well known that changes in the tumor microenvironment, such as hypoxia and glucose deprivation (GD), can induce VEGF production. Gadolinium 102-104 vascular endothelial growth factor A Homo sapiens 118-122 22915762-6 2012 cDNA microarray results showed that GD-induced UPR activation promoted upregulation of a number of proangiogenic mediators (VEGF, FGF-2, IL-6, etc.) Gadolinium 36-38 vascular endothelial growth factor A Homo sapiens 124-128 22915762-6 2012 cDNA microarray results showed that GD-induced UPR activation promoted upregulation of a number of proangiogenic mediators (VEGF, FGF-2, IL-6, etc.) Gadolinium 36-38 fibroblast growth factor 2 Homo sapiens 130-135 22915762-6 2012 cDNA microarray results showed that GD-induced UPR activation promoted upregulation of a number of proangiogenic mediators (VEGF, FGF-2, IL-6, etc.) Gadolinium 36-38 interleukin 6 Homo sapiens 137-141 22915762-8 2012 In vitro studies revealed that partially blocking UPR signaling by silencing protein kinase RNA-like ER kinase (PERK) or activating transcription factor 4 (ATF4) significantly reduced the production of angiogenesis mediators induced by GD. Gadolinium 236-238 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 77-110 22915762-8 2012 In vitro studies revealed that partially blocking UPR signaling by silencing protein kinase RNA-like ER kinase (PERK) or activating transcription factor 4 (ATF4) significantly reduced the production of angiogenesis mediators induced by GD. Gadolinium 236-238 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 112-116 22915762-8 2012 In vitro studies revealed that partially blocking UPR signaling by silencing protein kinase RNA-like ER kinase (PERK) or activating transcription factor 4 (ATF4) significantly reduced the production of angiogenesis mediators induced by GD. Gadolinium 236-238 activating transcription factor 4 Homo sapiens 121-154 22915762-8 2012 In vitro studies revealed that partially blocking UPR signaling by silencing protein kinase RNA-like ER kinase (PERK) or activating transcription factor 4 (ATF4) significantly reduced the production of angiogenesis mediators induced by GD. Gadolinium 236-238 activating transcription factor 4 Homo sapiens 156-160 23039636-10 2012 RESULTS: Individual raters were able to reliably characterize (with >0.8 dice similarity coefficient, DSC) the gadolinium-enhancing cores and extent of the edematous areas only slightly more than half of the time. Gadolinium 114-124 desmocollin 3 Homo sapiens 105-108 22949663-9 2012 Steered by nonspecific electrostatic, hydrophobic, and specific hydrogen-bonding interactions, Gd@C(82)(OH)(22) exhibits specific binding modes near the ligand-specificity loop S1", thereby inhibiting MMP-9 activity. Gadolinium 95-97 matrix metallopeptidase 9 Homo sapiens 201-206 22800579-6 2012 Gd-LPD nanocomplexes delivered to rat brains by convection-enhanced delivery were visible by MRI at 6 h, 24 h and 48 h after administration. Gadolinium 0-2 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 3-6 22461428-8 2012 Short application of gadolinium, reported to activate TRPC5 channels, evoked a transient Ca(2+) rise in NEB cells. Gadolinium 21-31 transient receptor potential cation channel, subfamily C, member 5 Mus musculus 54-59 22977333-4 2012 Thus, gadolinium-enhanced MR imaging is mandatory for the precise diagnosis of the mucin-producing carcinoma of the gallbladder. Gadolinium 6-16 LOC100508689 Homo sapiens 83-88 23035458-0 2012 Synthesis and characterization of Gd@C82-PVK and C60-PVK--a kind of fullerene-grafted polymer. Gadolinium 34-36 complement C8 beta chain Homo sapiens 37-40 23000580-6 2012 Gadolinium (Gd3(+)), a blocker of stretch-activated ion channels (SACs), inhibited the stretch-induced phosphorylation of Akt and GSK-3beta. Gadolinium 0-10 AKT serine/threonine kinase 1 Rattus norvegicus 122-125 23000580-6 2012 Gadolinium (Gd3(+)), a blocker of stretch-activated ion channels (SACs), inhibited the stretch-induced phosphorylation of Akt and GSK-3beta. Gadolinium 0-10 glycogen synthase kinase 3 beta Rattus norvegicus 130-139 22954188-2 2012 Specifically, gadolinium chelates of bis-5-hydroxytryptamide-DTPA (bis-5HT-DTPA(Gd)) have been used to image localized inflammation in animal models by detecting neutrophil-derived myeloperoxidase (MPO) activity at the inflammation site. Gadolinium 14-24 myeloperoxidase Mus musculus 181-196 22954188-2 2012 Specifically, gadolinium chelates of bis-5-hydroxytryptamide-DTPA (bis-5HT-DTPA(Gd)) have been used to image localized inflammation in animal models by detecting neutrophil-derived myeloperoxidase (MPO) activity at the inflammation site. Gadolinium 14-24 myeloperoxidase Mus musculus 198-201 22954188-2 2012 Specifically, gadolinium chelates of bis-5-hydroxytryptamide-DTPA (bis-5HT-DTPA(Gd)) have been used to image localized inflammation in animal models by detecting neutrophil-derived myeloperoxidase (MPO) activity at the inflammation site. Gadolinium 80-82 myeloperoxidase Mus musculus 181-196 22954188-2 2012 Specifically, gadolinium chelates of bis-5-hydroxytryptamide-DTPA (bis-5HT-DTPA(Gd)) have been used to image localized inflammation in animal models by detecting neutrophil-derived myeloperoxidase (MPO) activity at the inflammation site. Gadolinium 80-82 myeloperoxidase Mus musculus 198-201 22954188-6 2012 In vivo magnetic resonance imaging (MRI) in mice demonstrated that bis-HTrp-DTPA(Gd) was retained for up to 5 days in MPO-containing sites and cleared faster than bis-5HT-DTPA(Gd) from MPO-negative sites. Gadolinium 81-83 myeloperoxidase Mus musculus 118-121 22954188-6 2012 In vivo magnetic resonance imaging (MRI) in mice demonstrated that bis-HTrp-DTPA(Gd) was retained for up to 5 days in MPO-containing sites and cleared faster than bis-5HT-DTPA(Gd) from MPO-negative sites. Gadolinium 81-83 myeloperoxidase Mus musculus 185-188 22954188-7 2012 Bis-HTrp-DTPA(Gd) should offer improvements for MRI of MPO-mediated inflammation in vivo, especially in high-field MRI, which requires a higher dose of contrast agent. Gadolinium 14-16 myeloperoxidase Mus musculus 55-58 22763949-2 2012 Two lipid-functionalized gadolinium chelates have been investigated for the targeting of the human liver fatty acid binding protein (hL-FABP) as a means of increasing the sensitivity and specificity of intracellular-directed MRI probes. Gadolinium 25-35 fatty acid binding protein 1 Homo sapiens 133-140 22763949-4 2012 The interaction modes of a fatty acid and a bile acid based gadolinium complex with hL-FABP have been characterized by relaxometric and NMR experiments in solution with close-to-physiological protein concentrations. Gadolinium 60-70 fatty acid binding protein 1 Homo sapiens 84-91 22513956-19 2012 The mean number of new or enlarged gadolinium contrast-enhancing lesions was significantly decreased in the interferon beta and high-dose daclizumab group, compared with that in the interferon beta and placebo group. Gadolinium 35-45 interferon beta 1 Homo sapiens 108-123 22933824-3 2012 Surprisingly, the scanning tunneling spectroscopy results show that each metallic-like, Gd-doped SiNW exhibits room-temperature negative differential resistance (RT-NDR) behavior, which can be reproducible with various Gd dopings and is independent of the tips. Gadolinium 88-90 serine/threonine kinase 38 Homo sapiens 165-168 22649203-0 2012 Gadolinium compounds signaling through TLR4 and TLR7 in normal human macrophages: establishment of a proinflammatory phenotype and implications for the pathogenesis of nephrogenic systemic fibrosis. Gadolinium 0-10 toll like receptor 4 Homo sapiens 39-43 22649203-0 2012 Gadolinium compounds signaling through TLR4 and TLR7 in normal human macrophages: establishment of a proinflammatory phenotype and implications for the pathogenesis of nephrogenic systemic fibrosis. Gadolinium 0-10 toll like receptor 7 Homo sapiens 48-52 22578419-8 2012 Moreover, ventrally concentrated GD acts to promote the cleavage of Ea by Snk through an extracatalytic mechanism that is distinct from GD"s proteolytic activation of Snk. Gadolinium 33-35 snake Drosophila melanogaster 74-77 22648571-0 2012 Gadolinium-induced fibrosis is counter-regulated by CCN3 in human dermal fibroblasts: a model for potential treatment of nephrogenic systemic fibrosis. Gadolinium 0-10 cellular communication network factor 3 Homo sapiens 52-56 22716048-0 2012 Targeting of ICAM-1 on vascular endothelium under static and shear stress conditions using a liposomal Gd-based MRI contrast agent. Gadolinium 103-105 intercellular adhesion molecule 1 Homo sapiens 13-19 22607376-6 2012 One NSF theory is that Gadolinium chelates distribute into the extracellular fluid compartment and set Gadolinium ions free, depending on multiple factors among which the duration of chelates exposure is directly related to the renal function. Gadolinium 23-33 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 4-7 22607376-6 2012 One NSF theory is that Gadolinium chelates distribute into the extracellular fluid compartment and set Gadolinium ions free, depending on multiple factors among which the duration of chelates exposure is directly related to the renal function. Gadolinium 103-113 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 4-7 22271155-2 2012 We think that this was attributable to gadolinium leakage into the CSF due to increased leptomeningeal microvascular permeability in this patient with Todd"s paresis. Gadolinium 39-49 colony stimulating factor 2 Homo sapiens 67-70 22202439-7 2012 Lastly, considering calcium signaling, we observed upon Ga treatment an inhibition of calcium-induced Creb phosphorylation, as well as a blockade of gadolinium-induced calcium entry through TRPV-5 calcium channels. Gadolinium 149-159 transient receptor potential cation channel subfamily V member 5 Homo sapiens 190-196 22173753-0 2012 The role of MR myelography with intrathecal gadolinium in localization of spinal CSF leaks in patients with spontaneous intracranial hypotension. Gadolinium 44-54 colony stimulating factor 2 Homo sapiens 81-84 22020419-7 2012 High expression of mRNA encoding GATA3 and lymphotoxin-beta (LT-beta) was associated with low disease activity in Gd-enhanced MRI studies. Gadolinium 114-116 GATA binding protein 3 Homo sapiens 33-38 22434630-1 2012 Two novel Gd-based contrast agents (CAs) for the molecular imaging of matrix metalloproteinases (MMPs) were synthetized and characterized in vitro and in vivo. Gadolinium 10-12 matrix metallopeptidase 2 Mus musculus 97-101 22086330-1 2012 We previously reported that Gd-containing particles formed under physiological conditions act as active entities to enhance cell survival and promote S phase entry via activation of both mitogen-activated protein kinase/extracellular-signal-regulated protein kinase (ERK) and phosphatidylinositol 3-kinase/Akt signaling pathways. Gadolinium 28-30 mitogen-activated protein kinase 1 Homo sapiens 267-270 22086330-6 2012 After treatment with Gd-containing particles, a large number of vinculin-containing focal adhesions were maintained. Gadolinium 21-23 vinculin Homo sapiens 64-72 22020419-7 2012 High expression of mRNA encoding GATA3 and lymphotoxin-beta (LT-beta) was associated with low disease activity in Gd-enhanced MRI studies. Gadolinium 114-116 lymphotoxin beta Homo sapiens 43-59 22020419-7 2012 High expression of mRNA encoding GATA3 and lymphotoxin-beta (LT-beta) was associated with low disease activity in Gd-enhanced MRI studies. Gadolinium 114-116 lymphotoxin beta Homo sapiens 61-68 22223844-6 2012 In contrast, tumors that were less sensitive to anti-VEGF therapy showed an increase in (13)C flux from hyperpolarized [1-(13)C]pyruvate and an increase in uptake of a gadolinium contrast agent, whereas tumor ADC decreased. Gadolinium 168-178 vascular endothelial growth factor A Homo sapiens 53-57 22098598-9 2012 Sagittal Gd-enhanced T1-weighted MR imaging demonstrated an intradural, extramedullary, and uniformly enhancing mass that extended from L-3 to L-4. Gadolinium 9-11 immunoglobulin kappa variable 2-14 (pseudogene) Homo sapiens 136-139 22098598-9 2012 Sagittal Gd-enhanced T1-weighted MR imaging demonstrated an intradural, extramedullary, and uniformly enhancing mass that extended from L-3 to L-4. Gadolinium 9-11 ribosomal protein L4 Homo sapiens 143-146 22020731-8 2012 Induction of Delta[Ca(2+)](c,Gd) by alphaCD3 and ConA was inhibited by 2-aminoethoxydiphenyl borate (2-APB) and by N-(p-amylcinnamoyl) anthranilic acid, indicating that TRPM2 and TRPC are involved in this process. Gadolinium 29-31 transient receptor potential cation channel subfamily M member 2 Homo sapiens 169-174 22020731-9 2012 Treatment with Pyr-3, a TRPC3-specific inhibitor, potently suppressed Delta[Ca(2+)](c,Gd) by alphaCD3 (IC(50), 0.16 muM). Gadolinium 86-88 transient receptor potential cation channel subfamily C member 3 Homo sapiens 24-29 23006881-3 2012 MR imaging with gadolinium demonstrated a tumor-like longitudinal lesion, extending from the L1-2 to the L3-4 intervertebral disc spaces and occupying most of the right half of the vertebral canal. Gadolinium 16-26 LINE1 retrotransposable element 1 Homo sapiens 93-97 22200405-8 2012 The strong bonding in Gd(C(8)H(8)) arises from two-electron transfer from Gd to C(8)H(8), which creates a strong charge-charge interaction and converts the tub-shaped ligand into a planar form. Gadolinium 22-24 TUB bipartite transcription factor Homo sapiens 156-159 21929868-7 2012 Labeling for 4 h with low-dose concentration (125 muM lipid, corresponding to 52 +- 3 muM Gd) yielded an intracellular load of 30 +- 2.5 pg Gd cell(-1), without any effects on cell viability, proliferation, and cell differentiation. Gadolinium 90-92 latexin Homo sapiens 50-53 21929868-7 2012 Labeling for 4 h with low-dose concentration (125 muM lipid, corresponding to 52 +- 3 muM Gd) yielded an intracellular load of 30 +- 2.5 pg Gd cell(-1), without any effects on cell viability, proliferation, and cell differentiation. Gadolinium 90-92 latexin Homo sapiens 86-89 21929868-13 2012 In conclusion, Gd-loaded cationic liposomes (125 muM lipid) are an excellent candidate to label cells, without detrimental effects on cell viability, proliferation, and differentiation, and can be visualized by MRI. Gadolinium 15-17 latexin Homo sapiens 49-52 23198628-0 2012 Gadolinium-induced NSF claim resolved in favor of plaintiff. Gadolinium 0-10 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 19-22 22056512-3 2012 METHODS AND RESULTS: Purified human serum albumin (HSA) (5%) was labeled with Gd via the covalent binding of diethylenetriaminepentacetic acid. Gadolinium 78-80 albumin Homo sapiens 36-49 23006881-3 2012 MR imaging with gadolinium demonstrated a tumor-like longitudinal lesion, extending from the L1-2 to the L3-4 intervertebral disc spaces and occupying most of the right half of the vertebral canal. Gadolinium 16-26 ribosomal protein L34 Homo sapiens 105-109 21998307-8 2011 NMR spectra collected in presence of paramagnetic spin relaxation agents (5DSA, 16DSA, and Gd(DTPA-BMA)) indicated that the amphipathic alpha-helices of Hsp12 in SDS micelles lie on the membrane surface. Gadolinium 91-93 lipid-binding protein HSP12 Saccharomyces cerevisiae S288C 153-158 23284611-8 2012 Furthermore, GES prevented GD-induced phosphorylation of ERK1/2 in dorsal root ganglia. Gadolinium 27-29 mitogen-activated protein kinase 3 Homo sapiens 57-63 22084204-5 2012 Aortic root magnetic resonance imaging was performed after intravenous injection of the activatable MPO sensor (bis-5-hydroxytryptamide-diethylenetriaminepentatacetate gadolinium) (n = 23), referred to as MPO-Gd, or gadopentetate dimeglumine (n = 10). Gadolinium 168-178 myeloperoxidase Mus musculus 100-103 22629484-3 2012 CASE DESCRIPTION: We described a case of a 31-year-old male with a serum prolactin (PRL) value of 240 ng/ml Magnetic resonance imaging (MRI) showed a space-occupying mass within the sphenoid sinus (SS) which partially enhanced by gadolinium. Gadolinium 230-240 prolactin Homo sapiens 73-82 23082101-5 2012 For an integrated vascular-targeted PDT with magnetic resonance imaging (MRI) of cancer, we developed multifunctional gadolinium-based nanoparticles consisting of a surface-localized tumor vasculature targeting NRP-1 peptide and polysiloxane nanoparticles with gadolinium chelated by DOTA derivatives on the surface and a chlorin as photosensitizer. Gadolinium 118-128 neuropilin 1 Homo sapiens 211-216 21875748-5 2011 The magnetization of doped HAp nanorods increases with the concentration of doped Gd(3+). Gadolinium 82-84 scaffold attachment factor B Mus musculus 27-30 21605080-0 2011 Gadolinium inhibits prostate cancer PC3 cell migration and suppresses osteoclast differentiation in vitro. Gadolinium 0-10 chromobox 8 Homo sapiens 36-39 22073424-7 2004 Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al. Gadolinium 52-54 myeloperoxidase Homo sapiens 73-76 21328349-7 2011 Analysis of the gadolinium-sensitive conductance reveals a high permeability to calcium ions (PCa/PNa 80) with little selectivity between monovalent ions; similar to that reported elsewhere for TRPV5. Gadolinium 16-26 transient receptor potential cation channel subfamily V member 5 Homo sapiens 195-200 22073424-7 2004 Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al. Gadolinium 52-54 myeloperoxidase Homo sapiens 314-317 21917150-3 2011 RESULTS: In the present study, we show that Distal-less 2 (Dlx-2), a homeobox gene of the Dlx family that is involved in embryonic development, is induced in cancer cell lines dependently of reactive oxygen species (ROS) in response to glucose deprivation (GD), one of the metabolic stresses occurring in solid tumors. Gadolinium 257-259 distal-less homeobox 2 Homo sapiens 59-64 21987804-9 2011 Both Orai1 G98 mutants formed a nonselective Ca(2+)-permeable conductance that was relatively resistant to block by Gd(3+). Gadolinium 116-118 ORAI calcium release-activated calcium modulator 1 Homo sapiens 5-10 21860859-1 2011 We have studied for the first time the structural change of high-purity metallofullerene (Gd@C(82)) upon heat treatment in an ultra-high vacuum system (10(-10) Torr) and examined the decomposition product through successive analysis with MS, IR, Raman, TEM, EDS and XPS. Gadolinium 90-92 MFT2 Homo sapiens 253-256 21753024-9 2011 The effects of CCK were suppressed by the generic, nonselective cationic channel blockers, 2-aminoethyldiphenyl borate and flufenamic acid, but potentiated by gadolinium ion and lanthanum ion at 100 muM. Gadolinium 159-169 cholecystokinin Homo sapiens 15-18 21572008-7 2011 Inhibition of K(+) channels (1 mM tetraethylammonium or 100 muM 4-aminopyridine) and nonselective cation channels by 10 muM gadolinium (Gd(3+)) significantly reduced migration in the presence of CT-1. Gadolinium 124-134 cardiotrophin 1 Rattus norvegicus 195-199 21683796-6 2011 RESULTS: Direct delivery of Ad-BMP-6 demonstrated delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and histologic evidence of greater Glycosaminoglycan (GAG) content in repair tissue at 12 weeks, while Ad-BMP-2 had greater non-mineral cartilage at the surface at 52 weeks (p<0.04). Gadolinium 58-68 bone morphogenetic protein 6 Homo sapiens 31-36 21521627-0 2011 Gadolinium-loaded polymeric nanoparticles modified with Anti-VEGF as multifunctional MRI contrast agents for the diagnosis of liver cancer. Gadolinium 0-10 vascular endothelial growth factor A Homo sapiens 61-65 21521627-2 2011 Here, we designed a novel multifunctional polymeric nanoparticle contrast agent (Anti-VEGF PLA-PEG-PLL-Gd NP) simultaneously modified with Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and anti-vascular endothelial growth factor (VEGF) antibody to deliver Gd-DTPA to the tumor area and achieve the early diagnosis of hepatocellular carcinoma (HCC). Gadolinium 139-149 vascular endothelial growth factor A Homo sapiens 86-90 21558403-3 2011 We aim to establish whether a gadolinium (Gd)-based agent targeting the inflammatory enzyme myeloperoxidase (MPO) can selectively detect intra- and peritumoral inflammation as well as glioma response to treatment by MRI. Gadolinium 30-40 myeloperoxidase Homo sapiens 92-107 21558403-3 2011 We aim to establish whether a gadolinium (Gd)-based agent targeting the inflammatory enzyme myeloperoxidase (MPO) can selectively detect intra- and peritumoral inflammation as well as glioma response to treatment by MRI. Gadolinium 30-40 myeloperoxidase Homo sapiens 109-112 21558403-3 2011 We aim to establish whether a gadolinium (Gd)-based agent targeting the inflammatory enzyme myeloperoxidase (MPO) can selectively detect intra- and peritumoral inflammation as well as glioma response to treatment by MRI. Gadolinium 42-44 myeloperoxidase Homo sapiens 92-107 21558403-3 2011 We aim to establish whether a gadolinium (Gd)-based agent targeting the inflammatory enzyme myeloperoxidase (MPO) can selectively detect intra- and peritumoral inflammation as well as glioma response to treatment by MRI. Gadolinium 42-44 myeloperoxidase Homo sapiens 109-112 21689390-0 2011 Late gadolinium enhanced cardiovascular magnetic resonance of lamin A/C gene mutation related dilated cardiomyopathy. Gadolinium 5-15 lamin A/C Homo sapiens 62-71 21487014-7 2011 Furthermore, by using Gd(3+) or 2-aminoethoxydiphenyl borate to inhibit TRPM7 channels, the [Mg(2+)](i) increase, which was induced by OGD or CI, was attenuated without altering the basal level of [Mg(2+)](i). Gadolinium 22-24 transient receptor potential cation channel, subfamily M, member 7 Rattus norvegicus 72-77 21590807-6 2011 Furthermore, statistically significant increase of mean retinal apparent diffusion coefficient and gadolinium-diethylenetriaminepentaacetic acid-enhanced T(1)-weighted MRI signals were observed in 3-month-old rd1 mice comparing with age-matched wild-type mice. Gadolinium 99-109 phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide Mus musculus 209-212 21456529-10 2011 In particular, Gd MOF nanoparticles with an average size of 82 nm with the addition of NaSal, yielded a longitudinal relaxivity value of 83.9 mM-1 [Gd3+] sec-1, one of the highest reported values compared to other Gd-based nanoparticles in the literature to date. Gadolinium 15-17 secretory blood group 1, pseudogene Homo sapiens 154-159 21451883-5 2011 With the addition of one equivalent of Cu(II) to [Gd(Try-TTDA)(H(2)O)](2-) the indole fluorescence was completely quenched. Gadolinium 50-52 general transcription factor IIH subunit 5 Homo sapiens 57-61 21562271-7 2011 RGC responses to TRPV4-selective agonists and hypotonic stimulation were absent in Ca2+ -free saline and were antagonized by the nonselective TRP channel antagonists Ruthenium Red and gadolinium, but were unaffected by the TRPV1 antagonist capsazepine. Gadolinium 184-194 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 17-22 21334349-2 2011 MAIN METHODS: The effect of GD on the liver injury was examined by measuring the activities of serum transferases and hepatic antioxidant enzymes, histopathological analysis, gene expression profile, and proteins of the peroxisome proliferator-activated receptor alpha (PPARalpha) and met proto-oncogene (c-Met) in SD rats at 24 h after GalN administration. Gadolinium 28-30 peroxisome proliferator activated receptor alpha Rattus norvegicus 220-268 21542558-0 2004 Annexin A5-Gd-micelles-Cy5.5 Optical fluorescence imaging is increasingly being used to obtain images of biological functions of specific targets in vitro and in small animals (1, 2). Gadolinium 11-13 annexin A5 Mus musculus 0-10 21334349-2 2011 MAIN METHODS: The effect of GD on the liver injury was examined by measuring the activities of serum transferases and hepatic antioxidant enzymes, histopathological analysis, gene expression profile, and proteins of the peroxisome proliferator-activated receptor alpha (PPARalpha) and met proto-oncogene (c-Met) in SD rats at 24 h after GalN administration. Gadolinium 28-30 MET proto-oncogene, receptor tyrosine kinase Rattus norvegicus 305-310 21334349-2 2011 MAIN METHODS: The effect of GD on the liver injury was examined by measuring the activities of serum transferases and hepatic antioxidant enzymes, histopathological analysis, gene expression profile, and proteins of the peroxisome proliferator-activated receptor alpha (PPARalpha) and met proto-oncogene (c-Met) in SD rats at 24 h after GalN administration. Gadolinium 28-30 peroxisome proliferator activated receptor alpha Rattus norvegicus 270-279 21334349-3 2011 The effect of GD on the expression of PPARalpha and its target gene in AML-12 mouse hepatocytes was also examined. Gadolinium 14-16 peroxisome proliferator activated receptor alpha Mus musculus 38-47 21198628-7 2011 Activation of ER stress downstream substrates, inositol-requiring kinase 1 and ATF6, was also observed in Gd-treated cells. Gadolinium 106-108 activating transcription factor 6 Rattus norvegicus 79-83 21267611-11 2011 Co-incubation of BEAS-2B cells with both gadolinium and iron resulted in diminished release of IL-8 relative to levels of the cytokine following incubation with gadolinium alone. Gadolinium 41-51 C-X-C motif chemokine ligand 8 Homo sapiens 95-99 21267611-11 2011 Co-incubation of BEAS-2B cells with both gadolinium and iron resulted in diminished release of IL-8 relative to levels of the cytokine following incubation with gadolinium alone. Gadolinium 161-171 C-X-C motif chemokine ligand 8 Homo sapiens 95-99 21168332-0 2011 (13)C-labeled indolequinone-DTPA-Gd conjugate for NMR probing cytochrome:P450 reductase-mediated one-electron reduction. Gadolinium 33-35 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-77 21247114-8 2011 They are higher than those of [Gd(TTDA)(H(2)O)](2-) (146 x 10(6) s(-1)), [Gd(DTPA)(H(2)O)](2-) (4.1 x 10(6) s(-1)), and MS-325 (6.1 x 10(6) s(-1)). Gadolinium 31-33 general transcription factor IIH subunit 5 Homo sapiens 34-38 21247114-9 2011 Elevated stability and water exchange rate indicate that the presence of cyclobutyl on the carbon backbone imparts rigidity and steric constraint to [Gd(CB-TTDA)(H(2)O)](2-)and [Gd(Bz-CB-TTDA)(H(2)O)](2-). Gadolinium 150-152 general transcription factor IIH subunit 5 Homo sapiens 156-160 21247114-9 2011 Elevated stability and water exchange rate indicate that the presence of cyclobutyl on the carbon backbone imparts rigidity and steric constraint to [Gd(CB-TTDA)(H(2)O)](2-)and [Gd(Bz-CB-TTDA)(H(2)O)](2-). Gadolinium 150-152 general transcription factor IIH subunit 5 Homo sapiens 187-191 21247114-10 2011 In addition, the major objective for selecting the cyclobutyl is to tune the lipophilicity of [Gd(Bz-CB-TTDA)(H(2)O)](2-). Gadolinium 95-97 general transcription factor IIH subunit 5 Homo sapiens 104-108 21247114-11 2011 The binding affinity of [Gd(Bz-CB-TTDA)(H(2)O)](2-) to HSA was evaluated by ultrafiltration study across a membrane with a 30 kDa MW cutoff, and the first three stepwise binding constants were determined by fitting the data to a stoichiometric model. Gadolinium 25-27 general transcription factor IIH subunit 5 Homo sapiens 34-38 21247114-12 2011 The binding association constants (K(A)) for [Gd(CB-TTDA)(H(2)O)](2-) and [Gd(Bz-CB-TTDA)(H(2)O)](2-) are 1.1 x 10(2) and 1.5 x 10(3), respectively. Gadolinium 46-48 general transcription factor IIH subunit 5 Homo sapiens 52-56 21247114-12 2011 The binding association constants (K(A)) for [Gd(CB-TTDA)(H(2)O)](2-) and [Gd(Bz-CB-TTDA)(H(2)O)](2-) are 1.1 x 10(2) and 1.5 x 10(3), respectively. Gadolinium 46-48 general transcription factor IIH subunit 5 Homo sapiens 84-88 21247114-12 2011 The binding association constants (K(A)) for [Gd(CB-TTDA)(H(2)O)](2-) and [Gd(Bz-CB-TTDA)(H(2)O)](2-) are 1.1 x 10(2) and 1.5 x 10(3), respectively. Gadolinium 75-77 general transcription factor IIH subunit 5 Homo sapiens 52-56 21247114-12 2011 The binding association constants (K(A)) for [Gd(CB-TTDA)(H(2)O)](2-) and [Gd(Bz-CB-TTDA)(H(2)O)](2-) are 1.1 x 10(2) and 1.5 x 10(3), respectively. Gadolinium 75-77 general transcription factor IIH subunit 5 Homo sapiens 84-88 21247114-14 2011 As measured by the Zn(II) transmetalation process, the kinetic stabilities of [Gd(CB-TTDA)(H(2)O)](2-), [Gd(Bz-CB-TTDA)(H(2)O)](2-), and [Gd(DTPA)(H(2)O)](2-) are similar and are significantly higher than that of [Gd(DTPA-BMA)(H(2)O)](2-). Gadolinium 79-81 general transcription factor IIH subunit 5 Homo sapiens 85-89 21247114-15 2011 High thermodynamic and kinetic stability and optimized lipophilicity of [Gd(CB-TTDA)(H(2)O)](2-) make it a favorable blood pool contrast agent for MRI. Gadolinium 73-75 general transcription factor IIH subunit 5 Homo sapiens 79-83 21247114-0 2011 Synthesis and physicochemical characterization of carbon backbone modified [Gd(TTDA)(H2O)]2- derivatives. Gadolinium 76-78 general transcription factor IIH subunit 5 Homo sapiens 79-83 21247114-3 2011 The complexes [Gd(CB-TTDA)(H(2)O)](2-) and [Gd(Bz-CB-TTDA)(H(2)O)](2-) both display high stability constant (log K(GdL) = 20.28 and 20.09, respectively). Gadolinium 15-17 general transcription factor IIH subunit 5 Homo sapiens 21-25 21247114-5 2011 However, the stability constant values of [Gd(CB-TTDA)(H(2)O)](2-) and [Gd(Bz-CB-TTDA)(H(2)O)](2-) are lower than that of MS-325. Gadolinium 43-45 general transcription factor IIH subunit 5 Homo sapiens 49-53 21247114-5 2011 However, the stability constant values of [Gd(CB-TTDA)(H(2)O)](2-) and [Gd(Bz-CB-TTDA)(H(2)O)](2-) are lower than that of MS-325. Gadolinium 72-74 general transcription factor IIH subunit 5 Homo sapiens 81-85 21247114-7 2011 The water exchange rates are comparable for the two complexes, 232 x 10(6) s(-1) for [Gd(CB-TTDA)(H(2)O)](2-) and 271 x 10(6) s(-1) for [Gd(Bz-CB-TTDA)(H(2)O)](2-). Gadolinium 86-88 general transcription factor IIH subunit 5 Homo sapiens 92-96 21486253-2 2011 The human monocytic cell line THP-1 was labeled by overnight incubation with a gadolinium colloid (Gado CELLTrack) prior to determination of the in vitro release profile from T1-weighted MR images. Gadolinium 79-89 GLI family zinc finger 2 Homo sapiens 30-35 21486253-4 2011 THP-1 cells were found to be successfully--but not optimally--labeled with gadolinium colloid, and MR images demonstrated increased signal from labeled cells in both the synthetic and dynamic THP-1/HUVEC models. Gadolinium 75-85 GLI family zinc finger 2 Homo sapiens 0-5 20816837-9 2010 Based on previous reports that Ca(2+)(i) release also stimulates acid secretion in parietal cells, we showed that gadolinium-, thapsigargin-, and carbachol-mediated release of Ca(2+)(i) induced Shh expression. Gadolinium 114-124 sonic hedgehog Mus musculus 194-197 20970478-5 2011 We found that alpha4 integrin was up-regulated in all B-cell subsets from patients with CIS and that its expression was correlated with the number of gadolinium-enhanced lesions. Gadolinium 150-160 immunoglobulin binding protein 1 Homo sapiens 14-20 21146870-6 2011 Live cell imaging experiments with Fura-2 and NewPort Green DCF showed that overexpression of human TRPV6 increased the permeability for Ca(2+), Ba(2+), Sr(2+), Mn(2+), Zn(2+), Cd(2+), and interestingly also for La(3+) and Gd(3+). Gadolinium 223-225 transient receptor potential cation channel subfamily V member 6 Homo sapiens 100-105 21146870-8 2011 (45)Ca uptake experiments showed that cadmium, lanthanum and gadolinium were also highly efficient inhibitors of TRPV6-mediated calcium influx at higher micromolar concentrations. Gadolinium 61-71 transient receptor potential cation channel subfamily V member 6 Homo sapiens 113-118 21362318-2 2011 We hypothesized that hCPPs have the potential to selectively deliver a paramagnetic gadolinium probe into the matrix metalloproteinase 2 (MMP-2) positive human ovary adenocarcinoma cell lines, SKOV-3. Gadolinium 84-94 matrix metallopeptidase 2 Homo sapiens 110-136 21362318-2 2011 We hypothesized that hCPPs have the potential to selectively deliver a paramagnetic gadolinium probe into the matrix metalloproteinase 2 (MMP-2) positive human ovary adenocarcinoma cell lines, SKOV-3. Gadolinium 84-94 matrix metallopeptidase 2 Homo sapiens 138-143 20493266-2 2011 In agreement with previous works, the results demonstrate that the effect of gadolinium on water proton relaxivity is not constant, rising moderately with increase in the concentration of bovine serum albumin (BSA). Gadolinium 77-87 albumin Homo sapiens 195-208 20947830-6 2010 GD increased deacetylation of FoxO1, and Sirt1 was required for GD-induced deacetylation of FoxO1. Gadolinium 0-2 forkhead box O1 Mus musculus 30-35 20947830-7 2010 Overexpression of FoxO1(3A/LXXAA), which cannot interact with Sirt1, or p300, a histone acetylase, increased acetylation of FoxO1 and inhibited GD-induced autophagy. Gadolinium 144-146 forkhead box O1 Mus musculus 18-23 20947830-7 2010 Overexpression of FoxO1(3A/LXXAA), which cannot interact with Sirt1, or p300, a histone acetylase, increased acetylation of FoxO1 and inhibited GD-induced autophagy. Gadolinium 144-146 E1A binding protein p300 Mus musculus 72-76 20714270-1 2010 OBJECTIVE: The purpose of this study was to assess the effects of gadolinium (Gd3+), provided as gadolinium chloride, on fibroblast function. Gadolinium 66-76 GRDX Homo sapiens 78-81 20959327-0 2010 NFkappaB activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis. Gadolinium 95-105 nuclear factor kappa B subunit 1 Homo sapiens 0-8 21111984-10 2010 The hs-TnT levels were raised in patients with severe dyspnea: New York Heart Association (NYHA) functional class >=3 (P = .020), outflow obstruction (P = .013), systolic dysfunction (P = .037), abnormal blood pressure response (P = .036), and presence of gadolinium enhancement (P = .021). Gadolinium 259-269 troponin T1, slow skeletal type Homo sapiens 7-10 20696128-1 2010 Current through L-type calcium channels (Ca(V)1.2 or dihydropyridine receptor) can be blocked by micromolar concentrations of trivalent cations like the lanthanide gadolinium (Gd(3+)). Gadolinium 164-174 calcium voltage-gated channel subunit alpha1 C Homo sapiens 40-49 20696128-1 2010 Current through L-type calcium channels (Ca(V)1.2 or dihydropyridine receptor) can be blocked by micromolar concentrations of trivalent cations like the lanthanide gadolinium (Gd(3+)). Gadolinium 164-174 calcium voltage-gated channel subunit alpha1 S Homo sapiens 53-77 21254594-4 2010 ChitoCMG as well as zymosan increased the uptake of gadolinium by liver cells during preliminary (before gadolinium chloride) administration of beta-1,3-glucans. Gadolinium 52-62 hemoglobin, beta adult major chain Mus musculus 144-152 20182808-0 2010 A modified protocol using half-dose gadolinium in dynamic 3-Tesla magnetic resonance imaging for detection of ACTH-secreting pituitary tumors. Gadolinium 36-46 proopiomelanocortin Homo sapiens 110-114 20661146-11 2010 The higher basal levels of type I procollagen, matrix metalloproteinase-1, tissue inhibitor of metalloproteinases-1, and hyaluronan in the skin from ESRD patients could contribute to the sensitivity of this patient population to fibrotic changes, which might be induced by exposure to some of the gadolinium-based contrast agents. Gadolinium 297-307 TIMP metallopeptidase inhibitor 1 Homo sapiens 27-115 20944748-8 2010 Furthermore, knockdown of NMHC-IIA in the permissive cells inhibited HSV-1 infection as well as cell-cell fusion when gB, gD, gH and gL were coexpressed. Gadolinium 122-124 myosin heavy chain 9 Homo sapiens 26-34 20570728-10 2010 First, the activation of AMPK by GD was much stronger in C4-2 cells than in LNCaP cells, and the robustness of AMPK activation was correlated favorably with cell viability. Gadolinium 33-35 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 25-29 20570728-12 2010 The activation of AMPK by GD was functional, as demonstrated by appropriate phosphorylation changes of mTOR and mTOR downstream substrates. Gadolinium 26-28 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 18-22 20570728-12 2010 The activation of AMPK by GD was functional, as demonstrated by appropriate phosphorylation changes of mTOR and mTOR downstream substrates. Gadolinium 26-28 mechanistic target of rapamycin kinase Homo sapiens 103-107 20570728-12 2010 The activation of AMPK by GD was functional, as demonstrated by appropriate phosphorylation changes of mTOR and mTOR downstream substrates. Gadolinium 26-28 mechanistic target of rapamycin kinase Homo sapiens 112-116 21092491-8 2010 Gadolinium, nifedipine and LNA of MARCKS ED could reduce the increase the expression of SNAP23 and MUC5AC in cells and MUC5AC in supernatant (all P < 0.05). Gadolinium 0-10 synaptosome associated protein 23 Homo sapiens 88-94 21092491-8 2010 Gadolinium, nifedipine and LNA of MARCKS ED could reduce the increase the expression of SNAP23 and MUC5AC in cells and MUC5AC in supernatant (all P < 0.05). Gadolinium 0-10 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 99-105 21092491-8 2010 Gadolinium, nifedipine and LNA of MARCKS ED could reduce the increase the expression of SNAP23 and MUC5AC in cells and MUC5AC in supernatant (all P < 0.05). Gadolinium 0-10 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 119-125 20144889-2 2010 Organophosphate (OP) chemical warfare agents such as GD exert their toxic effects by inhibiting acetylcholinesterase (AChE) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). Gadolinium 53-55 acetylcholinesterase Callithrix jacchus 96-116 20144889-2 2010 Organophosphate (OP) chemical warfare agents such as GD exert their toxic effects by inhibiting acetylcholinesterase (AChE) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). Gadolinium 53-55 acetylcholinesterase Callithrix jacchus 118-122 20144889-10 2010 In the absence of PB pretreatment, the inhibition of RBC-AChE by GD was 98%. Gadolinium 65-67 acetylcholinesterase Callithrix jacchus 57-61 20651199-9 2010 At the lower boundary of the 95% CI for sensitivity, the savings incurred would come at the expense of administering gadolinium to 0.4% of patients with an eGFR less than 30 mL/min/1.73 m(2). Gadolinium 117-127 CD59 molecule (CD59 blood group) Homo sapiens 177-182 20698073-7 2004 On the other hand, paramagnetic T1 agents, such as gadolinium (Gd(3+)) and manganese (Mn(2+)), accelerate T1 relaxation and lead to brighter contrast images. Gadolinium 51-61 interleukin 1 receptor like 1 Homo sapiens 32-34 20698073-7 2004 On the other hand, paramagnetic T1 agents, such as gadolinium (Gd(3+)) and manganese (Mn(2+)), accelerate T1 relaxation and lead to brighter contrast images. Gadolinium 51-61 interleukin 1 receptor like 1 Homo sapiens 106-108 20698073-7 2004 On the other hand, paramagnetic T1 agents, such as gadolinium (Gd(3+)) and manganese (Mn(2+)), accelerate T1 relaxation and lead to brighter contrast images. Gadolinium 63-65 interleukin 1 receptor like 1 Homo sapiens 32-34 20698073-7 2004 On the other hand, paramagnetic T1 agents, such as gadolinium (Gd(3+)) and manganese (Mn(2+)), accelerate T1 relaxation and lead to brighter contrast images. Gadolinium 63-65 interleukin 1 receptor like 1 Homo sapiens 106-108 20698074-7 2004 On the other hand, paramagnetic T1 agents, such as gadolinium (Gd(3+)) and manganese (Mn(2+)), accelerate T1 relaxation and lead to brighter contrast images. Gadolinium 51-61 interleukin 1 receptor like 1 Homo sapiens 32-34 20698074-7 2004 On the other hand, paramagnetic T1 agents, such as gadolinium (Gd(3+)) and manganese (Mn(2+)), accelerate T1 relaxation and lead to brighter contrast images. Gadolinium 51-61 interleukin 1 receptor like 1 Homo sapiens 106-108 20698074-7 2004 On the other hand, paramagnetic T1 agents, such as gadolinium (Gd(3+)) and manganese (Mn(2+)), accelerate T1 relaxation and lead to brighter contrast images. Gadolinium 63-65 interleukin 1 receptor like 1 Homo sapiens 32-34 20698074-7 2004 On the other hand, paramagnetic T1 agents, such as gadolinium (Gd(3+)) and manganese (Mn(2+)), accelerate T1 relaxation and lead to brighter contrast images. Gadolinium 63-65 interleukin 1 receptor like 1 Homo sapiens 106-108 20398695-7 2010 Inhibition of both cytochrome c release and caspase-3 activation could significantly reduce Gd-induced neuron cell death. Gadolinium 92-94 caspase 3 Rattus norvegicus 44-53 20232209-0 2010 Localization of thoracic CSF leaks by gadolinium-enhanced MR-myelography and successful MR-targeted epidural blood patching: a case report. Gadolinium 38-48 colony stimulating factor 2 Homo sapiens 25-28 20237129-8 2010 High cerebrospinal fluid levels of chitinase 3-like 1 significantly correlated with the number of gadolinium enhancing lesions and the number of T2 lesions observed in brain magnetic resonance imaging scans performed at baseline, and were associated with disability progression during follow-up and shorter time to clinically definite multiple sclerosis (log-rank P-value=0.003). Gadolinium 98-108 chitinase 3 like 1 Homo sapiens 35-53 20514401-4 2010 In this study, we show that some cellular proteins including pro-apoptotic molecules p53, caspase-3, and caspase-9 and a pro-autophagic molecule beclin 1 are not released into the extracellular space but rather aggregated in the cytosol during GD-induced necrosis and that the protein aggregation occurs in a ROS-dependent manner. Gadolinium 244-246 beclin 1 Homo sapiens 145-153 27713291-5 2010 In a phase II randomized, placebo-controlled, double-blind trial in MS, 10,000 IU ingested IFN-alpha significantly decreased gadolinium enhancements compared to the placebo group at month 5. Gadolinium 125-135 interferon alpha 1 Homo sapiens 91-100 27713291-6 2010 TNF-alpha and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 177-187 tumor necrosis factor Homo sapiens 0-9 27713291-6 2010 TNF-alpha and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 177-187 interferon gamma Homo sapiens 14-23 27713291-6 2010 TNF-alpha and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 177-187 interferon alpha 1 Homo sapiens 153-162 20167234-2 2010 In addition, GD can provoke cytotoxic lesions in autoimmune diseases by interaction with MICA (MHC class I chain-related A) molecules, through NKG2D receptor on its surface. Gadolinium 13-15 MHC class I polypeptide-related sequence A Homo sapiens 89-93 20167234-2 2010 In addition, GD can provoke cytotoxic lesions in autoimmune diseases by interaction with MICA (MHC class I chain-related A) molecules, through NKG2D receptor on its surface. Gadolinium 13-15 MHC class I polypeptide-related sequence A Homo sapiens 95-122 20167234-2 2010 In addition, GD can provoke cytotoxic lesions in autoimmune diseases by interaction with MICA (MHC class I chain-related A) molecules, through NKG2D receptor on its surface. Gadolinium 13-15 killer cell lectin like receptor K1 Homo sapiens 143-157 20662951-3 2010 It has been proposed that in hemodialysis (HD) patients, iron mobilization (decreased total iron-binding capacity, increased iron level, and transferrin oversaturation) causes a transmetallation reaction and the release of free Gd from its chelator with the deposition of both Gd and iron in the affected tissues leading to fibrosis. Gadolinium 228-230 transferrin Homo sapiens 141-152 20577051-9 2010 Noninvasive magnetic resonance imaging of MPO with an MPO-activatable Gd-chelate revealed a spatially defined T1-weighted signal in rejected allografts but not in isografts or MPO-deficient allograft recipients. Gadolinium 70-72 myeloperoxidase Mus musculus 42-45 20577051-9 2010 Noninvasive magnetic resonance imaging of MPO with an MPO-activatable Gd-chelate revealed a spatially defined T1-weighted signal in rejected allografts but not in isografts or MPO-deficient allograft recipients. Gadolinium 70-72 myeloperoxidase Mus musculus 54-57 20577051-9 2010 Noninvasive magnetic resonance imaging of MPO with an MPO-activatable Gd-chelate revealed a spatially defined T1-weighted signal in rejected allografts but not in isografts or MPO-deficient allograft recipients. Gadolinium 70-72 myeloperoxidase Mus musculus 54-57 19898744-0 2010 Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1. Gadolinium 37-47 major histocompatibility complex, class I-related Rattus norvegicus 81-86 20544992-2 2010 METHODS: The Granzyme B mAb was coupled with DTPA,and then conjugated with Gd. Gadolinium 75-77 granzyme B Homo sapiens 13-23 19141485-0 2010 MR molecular imaging of thrombus: development and application of a Gd-based novel contrast agent targeting to P-selectin. Gadolinium 67-69 selectin P Canis lupus familiaris 110-120 20102371-3 2010 A short heptapeptide that selectively binds to IL-6R and which inhibits the effect of IL-6 was coupled to the magnetic resonance imaging (MRI) contrast agent gadolinium (Gd)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and the fluorescent dye rhodamine. Gadolinium 158-170 interleukin 6 receptor Homo sapiens 47-52 20102371-3 2010 A short heptapeptide that selectively binds to IL-6R and which inhibits the effect of IL-6 was coupled to the magnetic resonance imaging (MRI) contrast agent gadolinium (Gd)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and the fluorescent dye rhodamine. Gadolinium 158-170 interleukin 6 Homo sapiens 47-51 20215497-3 2010 NCAM-binding peptide-coated liposomes loaded with both doxorubicin and a lipophilic gadolinium (Gd) derivative were generated. Gadolinium 84-94 neural cell adhesion molecule 1 Mus musculus 0-4 19962723-6 2010 Inflammation, reflected as Gadolinium enhancement at magnetic resonance venography (MRV), was significantly decreased in the P-selectin treated group when compared to saline (IV 95% CI; -17.84 [-14.98-(-8.30)], p<0.00001, I(2)=80%). Gadolinium 27-37 selectin P Homo sapiens 125-135 20215497-3 2010 NCAM-binding peptide-coated liposomes loaded with both doxorubicin and a lipophilic gadolinium (Gd) derivative were generated. Gadolinium 96-98 neural cell adhesion molecule 1 Mus musculus 0-4 20221426-5 2010 Preliminary microarray studies, validated by quantitative real-time PCR, identified the differential expression of cellular genes associated with the NF-kappaB, PI3K/Akt, Jak/Stat and related Jak/Src pathways by virions lacking gB or gH but not gD. Gadolinium 245-247 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 196-199 20100462-4 2010 Transient receptor potential canonical 5 (TRPC5) is a Ca(2+)-permeable ion channel that is linked positively to innate fear responses and unusual amongst ion channels in being stimulated by trivalent lanthanides, which include gadolinium. Gadolinium 227-237 transient receptor potential cation channel subfamily C member 5 Homo sapiens 0-40 20100462-4 2010 Transient receptor potential canonical 5 (TRPC5) is a Ca(2+)-permeable ion channel that is linked positively to innate fear responses and unusual amongst ion channels in being stimulated by trivalent lanthanides, which include gadolinium. Gadolinium 227-237 transient receptor potential cation channel subfamily C member 5 Homo sapiens 42-47 19762462-0 2010 Intrathecal gadolinium-enhanced MR cisternography in the evaluation of CSF leakage. Gadolinium 12-22 colony stimulating factor 2 Homo sapiens 71-74 20043073-1 2010 Previously, we showed that mild heat shock modulates patterns of cell death in response to glucose deprivation (GD), a common characteristic of the tumor microenvironment, by switching necrosis to apoptosis through ERK-dependent suppression of reactive oxygen species production in A549 cells. Gadolinium 112-114 mitogen-activated protein kinase 1 Homo sapiens 215-218 20043073-5 2010 On the other hand, silencing of HSP27, but not of HSP70, reversed heat shock/GD-induced apoptosis to necrosis, and HSP27 overexpression suppressed GD-induced necrosis. Gadolinium 77-79 heat shock protein family B (small) member 1 Homo sapiens 32-37 20043073-8 2010 We also found that mild heat shock increased HSP27 and p53 protein levels dependent on PI3K and suppressed the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels dependent on PI3K and ERK1/2. Gadolinium 111-113 heat shock protein family B (small) member 1 Homo sapiens 45-50 20043073-8 2010 We also found that mild heat shock increased HSP27 and p53 protein levels dependent on PI3K and suppressed the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels dependent on PI3K and ERK1/2. Gadolinium 111-113 tumor protein p53 Homo sapiens 55-58 20043073-8 2010 We also found that mild heat shock increased HSP27 and p53 protein levels dependent on PI3K and suppressed the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels dependent on PI3K and ERK1/2. Gadolinium 111-113 heat shock protein family B (small) member 1 Homo sapiens 149-154 20043073-8 2010 We also found that mild heat shock increased HSP27 and p53 protein levels dependent on PI3K and suppressed the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels dependent on PI3K and ERK1/2. Gadolinium 111-113 tumor protein p53 Homo sapiens 159-162 20043073-8 2010 We also found that mild heat shock increased HSP27 and p53 protein levels dependent on PI3K and suppressed the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels dependent on PI3K and ERK1/2. Gadolinium 111-113 mitogen-activated protein kinase 3 Homo sapiens 200-206 20043073-9 2010 In conclusion, these results indicate that PI3K-dependent HSP27 and p53 induction and PI3K- and ERK1/2-dependent inhibition of the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels by heat play a key role(s) in heat shock-mediated switch of GD-induced necrosis to apoptosis. Gadolinium 131-133 mitogen-activated protein kinase 3 Homo sapiens 96-102 20043073-9 2010 In conclusion, these results indicate that PI3K-dependent HSP27 and p53 induction and PI3K- and ERK1/2-dependent inhibition of the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels by heat play a key role(s) in heat shock-mediated switch of GD-induced necrosis to apoptosis. Gadolinium 131-133 heat shock protein family B (small) member 1 Homo sapiens 169-174 20043073-9 2010 In conclusion, these results indicate that PI3K-dependent HSP27 and p53 induction and PI3K- and ERK1/2-dependent inhibition of the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels by heat play a key role(s) in heat shock-mediated switch of GD-induced necrosis to apoptosis. Gadolinium 131-133 tumor protein p53 Homo sapiens 179-182 20043073-9 2010 In conclusion, these results indicate that PI3K-dependent HSP27 and p53 induction and PI3K- and ERK1/2-dependent inhibition of the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels by heat play a key role(s) in heat shock-mediated switch of GD-induced necrosis to apoptosis. Gadolinium 258-260 mitogen-activated protein kinase 3 Homo sapiens 96-102 20043073-9 2010 In conclusion, these results indicate that PI3K-dependent HSP27 and p53 induction and PI3K- and ERK1/2-dependent inhibition of the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels by heat play a key role(s) in heat shock-mediated switch of GD-induced necrosis to apoptosis. Gadolinium 258-260 heat shock protein family B (small) member 1 Homo sapiens 169-174 20043073-9 2010 In conclusion, these results indicate that PI3K-dependent HSP27 and p53 induction and PI3K- and ERK1/2-dependent inhibition of the GD-induced increase in RIPA-insoluble HSP27 and p53 protein levels by heat play a key role(s) in heat shock-mediated switch of GD-induced necrosis to apoptosis. Gadolinium 258-260 tumor protein p53 Homo sapiens 179-182 19810686-4 2010 Photocleavage was effective at wavelengths ranging from 310 to 390 nm, and cleavage was inhibited by the addition of selected metal ions such as Gd(III) at moderate concentrations (2 mM). Gadolinium 145-147 mitochondrially encoded cytochrome c oxidase III Homo sapiens 148-151 20221273-6 2010 Gadolinium, a blocker of stretch-activated ion channels (SACs), inhibited the stretch-induced phosphorylation of AMPK and ACC, whereas diltiazem, a specific L-type calcium channel blocker, did not affect AMPK activation. Gadolinium 0-10 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 113-117 20043875-7 2010 High concentrations of Gadolinium (Gd(3+)) partially blocked FcepsilonRI-induced Ca(2+) influx in WT cells but, in contrast, completely inhibited Ca(2+) mobilization in Fyn -/- cells. Gadolinium 23-33 Fc receptor, IgE, high affinity I, gamma polypeptide Mus musculus 61-72 20043875-7 2010 High concentrations of Gadolinium (Gd(3+)) partially blocked FcepsilonRI-induced Ca(2+) influx in WT cells but, in contrast, completely inhibited Ca(2+) mobilization in Fyn -/- cells. Gadolinium 23-33 Fyn proto-oncogene Mus musculus 169-172 20675271-1 2010 The aim of this study was to estimate sodium iodide symporter (NIS) and thyroid peroxidase (TPO) expression in thyrocytes from patients with GD and no-toxic multinodular goitre (NTMG) in relationship with apoptotic (TIAR and TIA-1) markers. Gadolinium 141-143 thyroid peroxidase Homo sapiens 92-95 21220921-5 2010 Inhibition of Rho or Rho kinase (ROK) abolished [Ca(2+)](i) oscillations induced by Gd(3+), while the peak induced by high Ca(2+) was similar to control. Gadolinium 84-86 Rho-associated coiled-coil containing protein kinase 2 Mus musculus 21-31 21220921-9 2010 The transient cytosolic Ca(2+) oscillations produced by Gd(3+) are modulated by Rho-Rho kinase signaling, whereas the rapid peak of intracellular Ca(2+) in response to 5 mM [Ca(2+)](o) is mainly due to PLC/IP3 pathway activation. Gadolinium 56-58 Rho-associated coiled-coil containing protein kinase 2 Mus musculus 84-94 21220921-9 2010 The transient cytosolic Ca(2+) oscillations produced by Gd(3+) are modulated by Rho-Rho kinase signaling, whereas the rapid peak of intracellular Ca(2+) in response to 5 mM [Ca(2+)](o) is mainly due to PLC/IP3 pathway activation. Gadolinium 56-58 perlecan (heparan sulfate proteoglycan 2) Mus musculus 202-205 19956840-3 2010 In this study, we examined the effects of hypoxia on GD-induced necrosis and show that hypoxia prevented GD-induced mitochondrial ROS production, HMGB1 release, and necrosis and switched the cell death mode to apoptosis that is dependent on caspase-3 and -9. Gadolinium 105-107 high mobility group box 1 Homo sapiens 146-151 19956840-3 2010 In this study, we examined the effects of hypoxia on GD-induced necrosis and show that hypoxia prevented GD-induced mitochondrial ROS production, HMGB1 release, and necrosis and switched the cell death mode to apoptosis that is dependent on caspase-3 and -9. Gadolinium 105-107 caspase 3 Homo sapiens 241-257 19956840-7 2010 In conclusion, our results demonstrate that hypoxia switches GD-induced necrosis to apoptosis and ERK1/2 and PI3K-Akt exert anti-necrotic and pro-apoptotic activities in the cell death, respectively. Gadolinium 61-63 mitogen-activated protein kinase 3 Homo sapiens 98-104 19996758-1 2010 OBJECTIVE: Human skin produces increased amounts of matrix metalloproteinase-1 (MMP-1) when exposed in organ culture to Omniscan, one of the gadolinium-based MRI contrast agents (GBCA). Gadolinium 141-151 matrix metallopeptidase 1 Homo sapiens 52-78 19996758-1 2010 OBJECTIVE: Human skin produces increased amounts of matrix metalloproteinase-1 (MMP-1) when exposed in organ culture to Omniscan, one of the gadolinium-based MRI contrast agents (GBCA). Gadolinium 141-151 matrix metallopeptidase 1 Homo sapiens 80-85 19860742-10 2009 The ASIC channel antagonists gadolinium (0.1 mM) and amiloride (0.3 microM) reduced (P < 0.05) the acid-evoked (pH 6.5) release to 40 and 6.5% respectively. Gadolinium 29-39 acid sensing ion channel subunit 1 Rattus norvegicus 4-8 19893321-7 2010 7betaOHC produced an increase in extracellular signal-regulated kinase (ERK) phosphorylation that was blocked by inhibitors of store-operated calcium entry 2-aminoethoxydiphenyl borate and gadolinium. Gadolinium 189-199 mitogen-activated protein kinase 1 Homo sapiens 33-70 19893321-7 2010 7betaOHC produced an increase in extracellular signal-regulated kinase (ERK) phosphorylation that was blocked by inhibitors of store-operated calcium entry 2-aminoethoxydiphenyl borate and gadolinium. Gadolinium 189-199 mitogen-activated protein kinase 1 Homo sapiens 72-75 19864376-9 2010 Extracellular virions of the U(L)47 deletion mutant contained reduced amounts of gD, gB, gC, and VP22 but similar amounts of VP16 compared to those of wild-type or revertant virus particles. Gadolinium 81-83 tegument protein VP13/14 Bovine alphaherpesvirus 1 29-35 20003523-10 2009 In addition, ATP-stimulated C6 cells showed enhanced expression of the chemokines, MCP-1 and IL-8, with SKF96365 or gadolinium effective in reducing chemokine expression. Gadolinium 116-126 C-C motif chemokine ligand 2 Rattus norvegicus 83-88 20003523-11 2009 Gadolinium treatment of ATP-stimulated C6 cells was also found to inhibit the production of MCP-1 and IL-8. Gadolinium 0-10 C-C motif chemokine ligand 2 Rattus norvegicus 92-97 19131226-12 2009 Concomitant increase in vascular permeability caused by MIP-1, TNF-alpha and VEGF may lead to extravasation of chelated Gd or Gd-deposits. Gadolinium 120-122 zinc finger protein 667 Rattus norvegicus 56-61 19442697-7 2009 In conclusion our data indicate that a prolonged PPARgamma stimulation, by repeated administration of nanomolar pioglitazone or rosiglitazone concentrations, decreases GD-induced loss of differentiated SH-SY5Y cells. Gadolinium 168-170 peroxisome proliferator activated receptor gamma Homo sapiens 49-58 19131226-12 2009 Concomitant increase in vascular permeability caused by MIP-1, TNF-alpha and VEGF may lead to extravasation of chelated Gd or Gd-deposits. Gadolinium 120-122 tumor necrosis factor Rattus norvegicus 63-72 19131226-12 2009 Concomitant increase in vascular permeability caused by MIP-1, TNF-alpha and VEGF may lead to extravasation of chelated Gd or Gd-deposits. Gadolinium 120-122 vascular endothelial growth factor A Rattus norvegicus 77-81 19131226-12 2009 Concomitant increase in vascular permeability caused by MIP-1, TNF-alpha and VEGF may lead to extravasation of chelated Gd or Gd-deposits. Gadolinium 126-128 zinc finger protein 667 Rattus norvegicus 56-61 19131226-12 2009 Concomitant increase in vascular permeability caused by MIP-1, TNF-alpha and VEGF may lead to extravasation of chelated Gd or Gd-deposits. Gadolinium 126-128 tumor necrosis factor Rattus norvegicus 63-72 19131226-12 2009 Concomitant increase in vascular permeability caused by MIP-1, TNF-alpha and VEGF may lead to extravasation of chelated Gd or Gd-deposits. Gadolinium 126-128 vascular endothelial growth factor A Rattus norvegicus 77-81 20079140-10 2009 Apelin-13 pretreatment at 100 nmol/L significantly inhibited GD-induced cardiomyocyte apoptosis (P < 0.05) and increased Akt and mTOR phosphorylation (P < 0.01, P < 0.01). Gadolinium 61-63 apelin Rattus norvegicus 0-6 18599238-0 2009 Osteoid osteoma in atypical locations: the added value of dynamic gadolinium-enhanced MR imaging. Gadolinium 66-76 cell cycle regulator of NHEJ Homo sapiens 86-88 19665029-9 2009 DCE MRI further showed a 2-fold increase in the brain blood vessel permeability to gadolinium in IL-2 treated mice compared to controls. Gadolinium 83-93 interleukin 2 Mus musculus 97-101 19515638-9 2009 Furthermore, intrathecal and intraperitoneal injections of the TRPA1 inhibitor HC-03003 suppressed the response to noxious GD. Gadolinium 123-125 transient receptor potential cation channel, subfamily A, member 1 Rattus norvegicus 63-68 19515638-10 2009 CONCLUSIONS: The activation of TRPA1 in DRG neurons by noxious GD may be involved in acute visceral pain. Gadolinium 63-65 transient receptor potential cation channel, subfamily A, member 1 Rattus norvegicus 31-36 19557279-1 2009 X-Ray structure, photophysical and magnetic properties have been explored for the binuclear gadolinium(III) coordination complex based on bridging tetrathiafulvalenecarboxylate radical cations [Gd(hfac)(3)(micro-TTF (+)COO(-))](2). Gadolinium 92-102 ras homolog family member H Homo sapiens 212-215 19221779-3 2009 Twenty-one gadolinium enhanced T1 and 45 T2 weighted MRI scans were scored by two radiologists regarding the condition of the labyrinth. Gadolinium 11-21 interleukin 1 receptor like 1 Homo sapiens 31-43 19692842-1 2009 OBJECTIVES: To evaluate the relationship between T1 after intravenous contrast administration (T1Gd) and Delta relaxation rate (DeltaR1) = (1/T1(Gd) - 1/T1o) in the delayed Gadolinium-Enhanced MRI of cartilage (dGEMRIC) evaluation of cartilage repair tissue. Gadolinium 173-183 CD5 molecule Homo sapiens 142-148 19652086-5 2009 Delayed MPO(Gd) images (2 hours after injection) showed focal areas of increased contrast (>2-fold) in diseased wall but not in normal wall (P=0.84) compared with both DTPA(Gd) (n=11; P<0.001) and bis-tyr-DTPA(Gd) (n=3; P<0.05). Gadolinium 12-14 myeloperoxidase Oryctolagus cuniculus 8-11 19406336-8 2009 Gadolinium-based MR contrast media should be avoided in the presence of advanced renal failure with estimated glomerular filtration rate below 30 ml/min/1.73 m2, unless the diagnostic information is essential and not available with noncontrast magnetic resonance imaging techniques. Gadolinium 0-10 CD59 molecule (CD59 blood group) Homo sapiens 149-154 19241095-1 2009 The NMR diffusometry technique, based on the measurement of the diffusion coefficient of a ligand in the absence and in the presence of its macromolecular partner, was used to study the affinity for human serum albumin (HSA) of four gadolinium complexes, potential or already used magnetic resonance imaging contrast agents. Gadolinium 233-243 albumin Homo sapiens 205-218 19361169-2 2009 The X-ray structure of the 1:3 gadolinium complex [Gd(hfac)(3)(TTF-CONH-2-Pym-1-oxide)(3)](CH(2)Cl(2)).0.5C(6)H(14) reveals that the coordination polyhedron of the paramagnetic 4f (S = (7)/(2)) Gd(III) ion can be described as a 4,4,4-tricapped trigonal prism. Gadolinium 31-41 ras homolog family member H Homo sapiens 63-66 19361169-2 2009 The X-ray structure of the 1:3 gadolinium complex [Gd(hfac)(3)(TTF-CONH-2-Pym-1-oxide)(3)](CH(2)Cl(2)).0.5C(6)H(14) reveals that the coordination polyhedron of the paramagnetic 4f (S = (7)/(2)) Gd(III) ion can be described as a 4,4,4-tricapped trigonal prism. Gadolinium 51-53 ras homolog family member H Homo sapiens 63-66 19440623-1 2009 The conformational behaviour in aqueous solution of the EgadMe complex, a conditional gadolinium-based contrast agent sensitive to beta-galactosidase enzymatic activity, is investigated by means of ab initio calculations and classical molecular dynamics simulations. Gadolinium 86-96 galactosidase beta 1 Homo sapiens 131-149 18566870-7 2009 RESULTS: CA1 region neurons (90.8%) responded to GD, 50.6% of which showed excitation (GD-E neurons) and 49.4% showed inhibition (GD-I neurons). Gadolinium 49-51 carbonic anhydrase 1 Homo sapiens 9-12 19442953-1 2009 OBJECTIVES: We sought to determine whether gadolinium (Gd)-containing lipid-based nanoparticles (NPs) targeting the macrophage scavenger receptor-B (CD36) improve cardiac magnetic resonance (CMR) detection and characterization of human atherosclerosis. Gadolinium 43-53 CD36 molecule Homo sapiens 149-153 19442953-1 2009 OBJECTIVES: We sought to determine whether gadolinium (Gd)-containing lipid-based nanoparticles (NPs) targeting the macrophage scavenger receptor-B (CD36) improve cardiac magnetic resonance (CMR) detection and characterization of human atherosclerosis. Gadolinium 55-57 CD36 molecule Homo sapiens 149-153 19548441-7 2009 GD and GS could improve the hemodynamic index in SHR, and enhance the level of adiponectin and the expression of its related signal transduction molecules. Gadolinium 0-2 adiponectin, C1Q and collagen domain containing Rattus norvegicus 79-90 19421113-15 2009 Because the likelihood of developing NSF may vary with the type of gadolinium-based contrast agent used, the least toxic agent should be used. Gadolinium 67-77 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 37-40 19200860-3 2009 This choice has been influenced by the perception that interferon-beta preparations have greater efficacy than glatiramer acetate, due to apparently more rapid and robust reduction of gadolinium-enhancing lesions seen on magnetic resonance imaging in the pivotal trials of these agents. Gadolinium 184-194 interferon beta 1 Homo sapiens 55-70 19161209-8 2009 RESULTS: Mean Gadolinium-concentrations were higher in bowel loops of patients with more active disease, as defined by endoscopic and histopathological examination, CRP, and HBI. Gadolinium 14-24 C-reactive protein Homo sapiens 165-168 18953580-0 2009 Gadolinium-promoted cell cycle progression with enhanced S-phase entry via activation of both ERK and PI3K signaling pathways in NIH 3T3 cells. Gadolinium 0-10 mitogen-activated protein kinase 1 Mus musculus 94-97 20641796-0 2004 Anti-c-Met monoclonal antibody linked to biotinylated bovine serum albumin and gadolinium Gliomas and glioblastoma multiforme are characterized as highly infiltrative and invasive forms of brain cancer that may be treated with either surgical resection, chemotherapy, radiotherapy, or a combination of these modalities (1). Gadolinium 79-89 MET proto-oncogene, receptor tyrosine kinase Homo sapiens 5-10 20641204-6 2004 Gadolinium (Gd)-labeled DOTA-G-NH(CH2)11CO-RSPAYYTAA-(CH2CH2O)8-R (GdPCA2) is a proteinase-modulated contrast agent (PCA) for in vivo imaging of MMP-2 with magnetic resonance imaging (MRI) (6). Gadolinium 0-10 matrix metallopeptidase 2 Homo sapiens 145-150 20641204-6 2004 Gadolinium (Gd)-labeled DOTA-G-NH(CH2)11CO-RSPAYYTAA-(CH2CH2O)8-R (GdPCA2) is a proteinase-modulated contrast agent (PCA) for in vivo imaging of MMP-2 with magnetic resonance imaging (MRI) (6). Gadolinium 12-14 matrix metallopeptidase 2 Homo sapiens 145-150 18635615-0 2009 Persistence of gadolinium contrast enhancement in CSF: a possible harbinger of gadolinium neurotoxicity? Gadolinium 15-25 colony stimulating factor 2 Homo sapiens 50-53 18635615-0 2009 Persistence of gadolinium contrast enhancement in CSF: a possible harbinger of gadolinium neurotoxicity? Gadolinium 79-89 colony stimulating factor 2 Homo sapiens 50-53 21491811-5 2009 This case suggests a relationship between the pathogenesis of CIN with standard contrast media and CIN with gadolinium. Gadolinium 108-118 pyridoxal phosphatase Homo sapiens 62-65 19214684-5 2009 The present study investigated the diagnostic role of gadolinium-enhanced MR imaging of CTS. Gadolinium 54-64 transthyretin Homo sapiens 88-91 19214684-12 2009 Gadolinium enhancement was found in only 87% of patients with CTS who visited the hospital at an early stage and therefore had no nerve deficiency on electrophysiological studies (39%). Gadolinium 0-10 transthyretin Homo sapiens 62-65 19214684-15 2009 CONCLUSIONS: We conclude that gadolinium-enhanced MR imaging can detect not only morphological changes but also pathological changes of the median nerve in patients with CTS. Gadolinium 30-40 transthyretin Homo sapiens 170-173 19214684-16 2009 Currently, gadolinium-enhanced-MR imaging is probably most commonly used to image patients who have ambiguous electrodiagnostic studies and clinical examination in an early stage of CTS. Gadolinium 11-21 transthyretin Homo sapiens 182-185 19396315-4 2009 The most important risk factors for developing NSF are chronic or significant acute kidney disease (especially dialysis dependent patients) and the administration of gadolinium (GD3) containing contrast agents, agents that cause NSF by releasing free gadolinium (GD3) into tissues based on their pharmacokinetics. Gadolinium 166-176 GRDX Homo sapiens 178-181 19396315-4 2009 The most important risk factors for developing NSF are chronic or significant acute kidney disease (especially dialysis dependent patients) and the administration of gadolinium (GD3) containing contrast agents, agents that cause NSF by releasing free gadolinium (GD3) into tissues based on their pharmacokinetics. Gadolinium 166-176 GRDX Homo sapiens 263-266 19396315-4 2009 The most important risk factors for developing NSF are chronic or significant acute kidney disease (especially dialysis dependent patients) and the administration of gadolinium (GD3) containing contrast agents, agents that cause NSF by releasing free gadolinium (GD3) into tissues based on their pharmacokinetics. Gadolinium 251-261 GRDX Homo sapiens 178-181 19396315-4 2009 The most important risk factors for developing NSF are chronic or significant acute kidney disease (especially dialysis dependent patients) and the administration of gadolinium (GD3) containing contrast agents, agents that cause NSF by releasing free gadolinium (GD3) into tissues based on their pharmacokinetics. Gadolinium 251-261 GRDX Homo sapiens 263-266 19007810-2 2009 Although gadolinium-based MRI agents are thought to be safe in clinical use, the in vivo release of the toxic free inorganic gadolinium (Gd3+) has been reported in some patients with kidney disease. Gadolinium 125-135 GRDX Homo sapiens 137-140 21491811-5 2009 This case suggests a relationship between the pathogenesis of CIN with standard contrast media and CIN with gadolinium. Gadolinium 108-118 pyridoxal phosphatase Homo sapiens 99-102 19020260-0 2008 NSF-active and NSF-inert species of gadolinium: mechanistic and clinical implications. Gadolinium 36-46 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 0-3 18979271-0 2008 Gadolinium-enhanced three-dimensional magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging is superior to spin-echo imaging in delineating brain metastases. Gadolinium 0-10 long intergenic non-protein coding RNA 914 Homo sapiens 88-92 19020260-0 2008 NSF-active and NSF-inert species of gadolinium: mechanistic and clinical implications. Gadolinium 36-46 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 15-18 18701918-3 2008 Thus, an HSV1716 variant that expressed an anti-CD55 scFv targeting moiety linked to these gD residues was able to infect non-permissive Chinese hamster ovary cells expressing CD55 and this infection was specifically blocked by an anti-CD55 monoclonal antibody. Gadolinium 91-93 immunglobulin heavy chain variable region Homo sapiens 53-57 18938075-1 2008 Several novel gadolinium chelates conjugated with paclitaxel, colchicine and thyroxine have been prepared as MRI contrast agents targeted to tubulin and thyroxine-binding globulin, respectively. Gadolinium 14-24 serpin family A member 7 Homo sapiens 153-179 18701918-3 2008 Thus, an HSV1716 variant that expressed an anti-CD55 scFv targeting moiety linked to these gD residues was able to infect non-permissive Chinese hamster ovary cells expressing CD55 and this infection was specifically blocked by an anti-CD55 monoclonal antibody. Gadolinium 91-93 complement decay-accelerating factor Cricetulus griseus 48-52 20641737-0 2004 Gd@C82 Fullerenol Fullerenes, also known as buckyballs, are spheroidal carbon cages with a molecular formula of C2n (n = 30-41) and a diameter of ~1 nm (1). Gadolinium 0-2 complement C8 beta chain Homo sapiens 3-6 20641737-4 2004 For the Gd@C2n, the encapsulation of electropositive Gd atom leads to the transfer of electrons from the Gd atom to the electronegative fullerene cage, resulting in a zwitterion [Gd(3+)@C82(3-)]. Gadolinium 8-10 complement C8 beta chain Homo sapiens 186-189 20641737-4 2004 For the Gd@C2n, the encapsulation of electropositive Gd atom leads to the transfer of electrons from the Gd atom to the electronegative fullerene cage, resulting in a zwitterion [Gd(3+)@C82(3-)]. Gadolinium 53-55 complement C8 beta chain Homo sapiens 186-189 20641737-8 2004 Gd-Fullerenols (Gd@C82(OH)40) are water-soluble Gd endohedral metallofullerenes used with in vivo MRI (8). Gadolinium 0-2 complement C8 beta chain Homo sapiens 19-22 20641737-9 2004 The encapsulation of Gd has three electrons transferred to the C82 fullerene cage, resulting in zwitterions [Gd(3+)@C82(OH)40(3-)] in which seven unpaired electrons are located on the 4f-orbital of gadolinium ion and one unpaired electron is located on the fullerene cage. Gadolinium 198-208 complement C8 beta chain Homo sapiens 63-66 20641737-9 2004 The encapsulation of Gd has three electrons transferred to the C82 fullerene cage, resulting in zwitterions [Gd(3+)@C82(OH)40(3-)] in which seven unpaired electrons are located on the 4f-orbital of gadolinium ion and one unpaired electron is located on the fullerene cage. Gadolinium 198-208 complement C8 beta chain Homo sapiens 116-119 18701918-3 2008 Thus, an HSV1716 variant that expressed an anti-CD55 scFv targeting moiety linked to these gD residues was able to infect non-permissive Chinese hamster ovary cells expressing CD55 and this infection was specifically blocked by an anti-CD55 monoclonal antibody. Gadolinium 91-93 complement decay-accelerating factor Cricetulus griseus 176-180 18701918-3 2008 Thus, an HSV1716 variant that expressed an anti-CD55 scFv targeting moiety linked to these gD residues was able to infect non-permissive Chinese hamster ovary cells expressing CD55 and this infection was specifically blocked by an anti-CD55 monoclonal antibody. Gadolinium 91-93 complement decay-accelerating factor Cricetulus griseus 176-180 19489305-3 2008 Gadolinium accumulation in the liver peaked after 24 h and was accompanied by a decrease in activities of cathepsin D and cathepsin B and concentration of matrix metalloprotease-2. Gadolinium 0-10 cathepsin D Mus musculus 106-117 18847248-3 2008 The addition of gadolinium ions into the host glass matrix leads to an increase of the glass network polymerization due to the replacement of P-O-P bonds by the more resistant P-O-Te bonds having as result the improvement of the chemical durability of the glass. Gadolinium 16-26 POTE ankyrin domain family member D Homo sapiens 176-182 19267105-0 2008 Disappearance of gadolinium enhancement in a chemoresistant astrocytoma of the tectum after high-dose interferon beta. Gadolinium 17-27 interferon beta 1 Homo sapiens 102-117 19267105-3 2008 Interferon beta caused the disappearance of the gadolinium-enhanced lesion in the tectum. Gadolinium 48-58 interferon beta 1 Homo sapiens 0-15 19002053-7 2008 CONCLUSIONS: The release of Gd from all linear Gd3+ complexes in human serum was several orders of magnitude greater than predicted by the conditional stability constants. Gadolinium 28-30 GRDX Homo sapiens 47-50 19489305-3 2008 Gadolinium accumulation in the liver peaked after 24 h and was accompanied by a decrease in activities of cathepsin D and cathepsin B and concentration of matrix metalloprotease-2. Gadolinium 0-10 cathepsin B Mus musculus 122-133 18661197-3 2008 Lanthanum and gadolinium ions, potential blockers of mechanosensitive calcium ion-permeable channels (mechanoreceptors), nullified reorientation of microtubules as well as up-regulation of expression of VaTUG and VaGCP3 by hypergravity. Gadolinium 14-24 tubulin gamma-1 chain Vigna angularis 203-208 18555982-8 2008 Aging rate constants of GF-, GD-, and VR-inhibited monkey AChEs were very similar to human AChE except for GF-inhibited monkey AChEs, which aged 2-3 times faster than the human enzyme. Gadolinium 29-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 18615702-11 2008 In addition, our study shows, for the first time, the utility of micro MRI in conjunction with gadolinium-labeled A beta labeling agents to monitor the therapeutic response to amyloid-reducing agents. Gadolinium 95-105 amyloid beta (A4) precursor protein Mus musculus 114-120 18538448-9 2008 Higher levels of gadolinium in skin correlated with younger age, lower body weight, lower corrected serum calcium levels, and lower erythropoietin dosing. Gadolinium 17-27 erythropoietin Homo sapiens 132-146 18680095-2 2008 Here, dual functional Gd-fluorescein isothiocyanate mesoporous silica nanoparticles (Gd-Dye@MSN) that possess green fluorescence and paramagnetism are developed in order to evaluate their potential as effective T1-enhancing trackers for human mesenchymal stem cells (hMSCs). Gadolinium 22-24 moesin Homo sapiens 92-95 18344005-4 2008 Marketed gadolinium chelates can be classified according to key molecular design parameters: (a) nature of the chelating moiety: macrocyclic molecules in which Gd3+ is caged in the pre-organized cavity of the ligand, or linear open-chain molecules, (b) ionicity: the ionicity of the complex varies from neutral to tri-anionic agents, and (c) the presence or absence of an aromatic lipophilic residue responsible for protein binding. Gadolinium 9-19 GRDX Homo sapiens 160-163 17714904-1 2008 PURPOSE: To assess the added value of T2-weighted MRI to gadolinium-enhanced dynamic MRI for detection of HCCs. Gadolinium 57-67 holocytochrome c synthase Homo sapiens 106-110 17714904-9 2008 CONCLUSION: The addition of T2-weighted imaging to gadolinium-enhanced 3D dynamic imaging could be helpful in the detection of HCC by increasing reader confidence for HCCs with equivocal findings on gadolinium-enhanced MRIs. Gadolinium 51-61 holocytochrome c synthase Homo sapiens 167-171 18666152-0 2008 Is NSF only the tip of the "gadolinium toxicity" iceberg? Gadolinium 28-38 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 3-6 18539597-5 2008 The alpha1(V) THP protected MMP-12 from the NMR line broadening effects of Gd .EDTA in the active site cleft and more dramatically in the V-B loop next to the primed subsites. Gadolinium 75-77 collagen type V alpha 1 chain Homo sapiens 4-13 18539597-5 2008 The alpha1(V) THP protected MMP-12 from the NMR line broadening effects of Gd .EDTA in the active site cleft and more dramatically in the V-B loop next to the primed subsites. Gadolinium 75-77 matrix metallopeptidase 12 Homo sapiens 28-34 18270818-4 2008 The exocytotic mechanism of neurotransmitter release induced by 300 microM gadolinium was additionally verified by the fluorescent dye FM2-10. Gadolinium 75-85 neuromedin U receptor 2 Rattus norvegicus 135-141 18576649-1 2008 We describe the rational design of a novel class of magnetic resonance imaging (MRI) contrast agents with engineered proteins (CAi.CD2, i = 1, 2,..., 9) chelated with gadolinium. Gadolinium 167-177 CD2 antigen Mus musculus 131-134 18538797-7 2008 TRPC4 downregulation was also achieved by increasing extracellular calcium and was attenuated by gadolinium and MG132, suggesting that TRPC4 protein is regulated by intracellular calcium concentration and/or the ubiquitin-proteasome pathway. Gadolinium 97-107 transient receptor potential cation channel, subfamily C, member 4 Rattus norvegicus 0-5 18538797-7 2008 TRPC4 downregulation was also achieved by increasing extracellular calcium and was attenuated by gadolinium and MG132, suggesting that TRPC4 protein is regulated by intracellular calcium concentration and/or the ubiquitin-proteasome pathway. Gadolinium 97-107 transient receptor potential cation channel, subfamily C, member 4 Rattus norvegicus 135-140 18410503-7 2008 We found that GD induced the formation of fibrillary aggregated alpha-syn inclusions containing the DA transporter in dopaminergic cells. Gadolinium 14-16 synuclein alpha Homo sapiens 64-73 18410503-7 2008 We found that GD induced the formation of fibrillary aggregated alpha-syn inclusions containing the DA transporter in dopaminergic cells. Gadolinium 14-16 solute carrier family 6 member 3 Homo sapiens 100-114 18585501-13 2008 Matrix metalloproteinase 9 was associated with the presence of gadolinium enhancement in CMR (P = .001) and correlated with NT-proBNP (r = 0.52, P < .001). Gadolinium 63-73 matrix metallopeptidase 9 Homo sapiens 0-26 18585501-17 2008 CONCLUSIONS: Matrix metalloproteinase 9 is independently associated with gadolinium enhancement on CMR in patients with hypertrophic cardiomyopathy, suggesting that the MMP system has an important role in cardiac remodeling and fibrosis in this condition. Gadolinium 73-83 matrix metallopeptidase 9 Homo sapiens 13-39 18270818-5 2008 We found that 200 microM of RGDS peptide, an inhibitor of integrins, decreased polyvalent gadolinium-induced [3H]D: -aspartate release by 26%. Gadolinium 90-100 ral guanine nucleotide dissociation stimulator Rattus norvegicus 28-32 18570516-3 2008 Calculations have also been performed for endohedral metallofullerene Gd@C(82) to demonstrate the possible use of shake-up processes to identify the charge transfer between the metal ion and the carbon cage. Gadolinium 70-72 complement C8 beta chain Homo sapiens 73-78 18342468-4 2008 From those data it is obvious that the prevalence of NSF is significantly higher after the unstable agent gadodiamide than after any other gadolinium-based agent (3-7% versus 0-1% per injection) in patients with reduced renal function. Gadolinium 139-149 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 53-56 18501785-0 2008 C-reactive protein levels and clinical symptoms following gadolinium administration in hemodialysis patients. Gadolinium 58-68 C-reactive protein Homo sapiens 0-18 18326500-9 2008 Thapsigargin stimulation of cells expressing TRPC1+STIM1 activated a non-selective cation current, I(SOC), that was blocked by 1 microm Gd(3+) and 2-APB. Gadolinium 136-138 transient receptor potential cation channel subfamily C member 1 Homo sapiens 45-50 18326500-9 2008 Thapsigargin stimulation of cells expressing TRPC1+STIM1 activated a non-selective cation current, I(SOC), that was blocked by 1 microm Gd(3+) and 2-APB. Gadolinium 136-138 stromal interaction molecule 1 Homo sapiens 51-56 18256315-6 2008 ARPKD 5E cells treated with Gd(3+), an inhibitor of nonselective cation channels, inhibited but did not abolish the shear-induced [Ca(2+)](i) transient. Gadolinium 28-30 PKHD1 ciliary IPT domain containing fibrocystin/polyductin Homo sapiens 0-5 18353554-7 2008 A slight increase in serum FGF-2 levels was also found in R-R MS patients during relapse with gadolinium enhancing lesions and in SP patients with disability progression. Gadolinium 94-104 fibroblast growth factor 2 Homo sapiens 27-32 18256307-7 2008 Cell-attached patch-clamp experiments revealed that ANG II-induced membrane currents were enhanced by overexpression of pkd2 but significantly inhibited by knock down of pkd2, 30 microM Gd(3+) (a PC2 channel blocker), and dominant-negative pkd2 mutant (pkd2-D511V). Gadolinium 186-188 angiogenin Homo sapiens 52-55 18395090-9 2008 Splanchnic nerve resection, but not vagotomy, affected the visceromotor response, and attenuated the ERK1/2 activation in DRG neurons produced by GD. Gadolinium 146-148 mitogen activated protein kinase 3 Rattus norvegicus 101-107 18317931-0 2008 Differential regulation of neutrophil CD18 integrin function by di- and tri-valent cations: manganese vs. gadolinium. Gadolinium 106-116 integrin subunit beta 2 Homo sapiens 38-42 18317931-2 2008 We compared the roles of Mn(2+) (Manganese) and Gd(3+) (Gadolinium) in regulating leukocyte CD18-integrin function. Gadolinium 56-66 integrin subunit beta 2 Homo sapiens 92-96 18395090-10 2008 Furthermore, intrathecal administration of the mitogen-activated protein kinase kinase 1/2 inhibitor, U0126, altered the response to noxious GD. Gadolinium 141-143 mitogen activated protein kinase kinase 1 Rattus norvegicus 47-90 18395090-11 2008 CONCLUSIONS: The activation of ERK1/2 pathways in DRG neurons by noxious GD may be correlated with functional activity, and may be involved in acute visceral pain. Gadolinium 73-75 mitogen activated protein kinase 3 Rattus norvegicus 31-37 20641469-11 2004 C3d-SA-GdAF consists of three components, a biotinylated Gd-loaded apoferritin, a streptavidin, and a biotinylated C3d dendrimer (C3d-Bio). Gadolinium 7-9 endogenous retrovirus group K member 13 Homo sapiens 0-3 18360712-5 2008 Here we show that mild, but not harsh, heat shock prevented GD-induced necrosis and switched the cell death mode to apoptosis in A549 cells through the ERK1/2 pathway that could suppress GD-induced CuZnSOD release and ROS production. Gadolinium 187-189 mitogen-activated protein kinase 3 Homo sapiens 152-158 18226426-6 2008 Treatment of atria with gadolinium, a blocker for SACs, attenuated the ECF translocation and the ANP secretion induced by volume load. Gadolinium 24-34 natriuretic peptide A Rattus norvegicus 97-100 20641423-0 2004 Annexin A5-quantum dot-DTPA-gadolinium Optical fluorescence imaging is increasingly used to monitor biological functions of specific targets (1-3). Gadolinium 28-38 annexin A5 Homo sapiens 0-10 18187402-1 2008 PURPOSE: To prospectively determine in an animal model whether an ionic gadolinium (Gd(3+)) chelate conjugate of the C2A domain of synaptotagmin I can be used with magnetic resonance (MR) imaging to detect tumor cell death noninvasively in vivo. Gadolinium 72-82 synaptotagmin 1 Homo sapiens 131-146 18247608-1 2008 High relaxivity macromolecular contrast agents based on the conjugation of gadolinium chelates to the interior and exterior surfaces of MS2 viral capsids are assessed. Gadolinium 75-85 MS2 Homo sapiens 136-139 18096235-0 2008 Synthesis of a new gadolinium complex with a high affinity for human serum albumin and its manifold physicochemical characterization by proton relaxation rate analysis, NMR diffusometry and electrospray mass spectrometry. Gadolinium 19-29 albumin Homo sapiens 69-82 18096235-1 2008 A novel gadolinium complex, derived from Gd-DTPA (DTPA: diethylenetriaminepentaacetic acid) and sulfaphenazole, intended to be a potential MRI contrast agent and to interact with human serum albumin (HSA), was synthesized and characterized. Gadolinium 8-18 albumin Homo sapiens 185-198 18201801-5 2008 However, when NOS inhibitor nitro-l-arginine methyl ester (l-NAME) was administrated previously, the followed motilin-induced excitatory responsiveness of GD-responsive neurons was reduced. Gadolinium 155-157 motilin Rattus norvegicus 110-117 18201801-6 2008 In contrast, discharge activity of GD-responsive neurons with motilin was enhanced by pretreatment of NO precursor l-arginine. Gadolinium 35-37 motilin Rattus norvegicus 62-69 18201801-8 2008 Our findings suggested that motilin excited the GD-responsive neurons in the hippocampal CA1 region and the excitatory effect of motilin may be mediated by the endogenous NO. Gadolinium 48-50 motilin Rattus norvegicus 28-35 18201801-8 2008 Our findings suggested that motilin excited the GD-responsive neurons in the hippocampal CA1 region and the excitatory effect of motilin may be mediated by the endogenous NO. Gadolinium 48-50 carbonic anhydrase 1 Rattus norvegicus 89-92 18268141-3 2008 We have used a small-molecule, gadolinium-based activatable sensor for magnetic resonance imaging of MPO activity (MPO-Gd). Gadolinium 31-41 myeloperoxidase Mus musculus 101-104 18268141-3 2008 We have used a small-molecule, gadolinium-based activatable sensor for magnetic resonance imaging of MPO activity (MPO-Gd). Gadolinium 31-41 myeloperoxidase Mus musculus 115-118 18184835-2 2008 This hyperintensity was believed due to CSF gadolinium enhancement, a finding that would be anticipated in light of the suspected pathogenesis of increased microvascular permeability in PRES. Gadolinium 44-54 colony stimulating factor 2 Homo sapiens 40-43 18083188-10 2008 Cardioprotection by Gd was abolished by inhibition of JAK-2 with AG-490, of p42/44 MAPK with PD98059 or of K(ATP) channels with glibenclamide. Gadolinium 20-22 Janus kinase 2 Rattus norvegicus 54-59 18083188-10 2008 Cardioprotection by Gd was abolished by inhibition of JAK-2 with AG-490, of p42/44 MAPK with PD98059 or of K(ATP) channels with glibenclamide. Gadolinium 20-22 mitogen activated protein kinase 3 Rattus norvegicus 83-87 18083188-12 2008 Inhibition of JAK-2 also blocked Gd-induced delayed cardioprotection. Gadolinium 33-35 Janus kinase 2 Rattus norvegicus 14-19 18083188-14 2008 The mechanism underlying Gd-induced preconditioning appears to be multi-factorial, involving JAK-2, STAT-3 and p44 MAPK pathways, as well as K(ATP) channels. Gadolinium 25-27 Janus kinase 2 Rattus norvegicus 93-98 18083188-14 2008 The mechanism underlying Gd-induced preconditioning appears to be multi-factorial, involving JAK-2, STAT-3 and p44 MAPK pathways, as well as K(ATP) channels. Gadolinium 25-27 signal transducer and activator of transcription 3 Rattus norvegicus 100-106 18083188-14 2008 The mechanism underlying Gd-induced preconditioning appears to be multi-factorial, involving JAK-2, STAT-3 and p44 MAPK pathways, as well as K(ATP) channels. Gadolinium 25-27 mitogen activated protein kinase 3 Rattus norvegicus 111-114 18083188-14 2008 The mechanism underlying Gd-induced preconditioning appears to be multi-factorial, involving JAK-2, STAT-3 and p44 MAPK pathways, as well as K(ATP) channels. Gadolinium 25-27 mitogen activated protein kinase 3 Rattus norvegicus 115-119 18194445-4 2008 We used a magnetic resonance imaging (MRI) molecular targeting agent to specifically tag the cell surface receptor, c-Met, with an anti-c-Met antibody (Ab) linked to biotinylated Gd (gadolinium)-DTPA (diethylene triamine penta acetic acid)-albumin in rat gliomas to detect overexpression of this antigen in vivo. Gadolinium 179-181 MET proto-oncogene, receptor tyrosine kinase Rattus norvegicus 136-141 17976367-6 2008 The activation of CaSR by magnesium, calcium, neomycin, and gadolinium did not affect the expression of FLAG-tagged claudin-16, CaSR, or ZO-1, a tight junctional scaffolding protein. Gadolinium 60-70 calcium sensing receptor Canis lupus familiaris 18-22 17992679-6 2008 Here we describe the design and synthesis of a novel beta-galactosidase-activated MRI contrast agent, the Gd(3+) complex [Gd-5], by using the RIME approach. Gadolinium 106-108 galactosidase beta 1 Homo sapiens 53-71 17884814-10 2007 Further evidence for a similarity in the actions of lanthanoids and H(+) on TRPC5 is the reduction in single channel conductance and dramatic increase in channel open probability in the presence of either H(+) or Gd(3+) that leads to larger integral currents. Gadolinium 213-215 transient receptor potential cation channel subfamily C member 5 Homo sapiens 76-81 18633995-4 2008 However, gadolinium-containing contrast agents used in magnetic resonance imaging or angiography have recently been strongly linked to the development of fibrosis in NSF. Gadolinium 9-19 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 166-169 17940339-0 2008 In vivo magnetic resonance imaging of atherosclerotic lesions with a newly developed Evans blue-DTPA-gadolinium contrast medium in apolipoprotein-E-deficient mice. Gadolinium 101-111 apolipoprotein E Mus musculus 131-147 17942156-5 2008 However, Western blot analyses revealed significant changes in glutamate receptor protein immunoreactivity for subunits GluR2, NMDAR1, NMDAR2a and NMDAR2b in the hippocampi of GD-exposed guinea pigs. Gadolinium 176-178 glutamate receptor 2 Cavia porcellus 120-125 18202523-3 2007 Gd suppressed styrene-inducible CYP1A2 expression, but only at the protein level. Gadolinium 0-2 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 32-38 17884814-3 2007 Unlike most other Ca(2+)-permeable channels, TRPC4 and -5 are potentiated by micromolar concentrations of La(3+) and Gd(3+). Gadolinium 117-119 transient receptor potential cation channel subfamily C member 4 Homo sapiens 45-57 18058865-3 2007 The interaction of three gadolinium contrast agents (Gd-EOB-DTPA, Gd-BOPTA and MP-2269) with human serum albumin was assessed through the measurement of proton relaxation rate enhancement in various experimental conditions. Gadolinium 25-35 albumin Homo sapiens 99-112 18006838-6 2007 This Ca(2+)-sensing current can be inhibited by Gd(3+), 2-aminoethoxydiphenyl borate (2-APB), or intracellular Mg(2+), consistent with the TRPM7 current being activated. Gadolinium 48-50 transient receptor potential cation channel subfamily M member 7 Homo sapiens 139-144 17970723-5 2007 TRPA1 antagonists camphor and gadolinium, and a general TRP blocker ruthenium red inhibited TRPA1 activation by acetaldehyde. Gadolinium 30-40 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 0-5 17900152-8 2007 The most significant enhancement was observed in the reactivation of human AChE inhibited by nerve agents containing bulky side chains GF, GD, and VR, by H-series oximes HLo-7, HI-6, and ICD-585. Gadolinium 139-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17611636-4 2007 Here we show that EP prevented GD-induced necrosis and HMGB1 release and switched the cell death mode to apoptosis through inhibiting GD-induced CuZn superoxide dismutase release and ROS production. Gadolinium 31-33 high mobility group box 1 Homo sapiens 55-60 17671738-12 2007 The MRI findings in MS patients with the CCR5-Delta32 genotype exhibited lower positive gadolinium enhancing-imaging (p=0.0013) and lower brain atrophy (p=0.1333) than MS patients with the CCR5 wild-type genotype. Gadolinium 88-98 C-C motif chemokine receptor 5 Homo sapiens 41-45 17592591-5 2007 On the basis of the water-exchange rate values available for [Gd(TTDA-BMA)(H2O)], [Gd(TTDA-BBA)(H2O)] and [Gd(TTDA-N-MOBA)(H2O)]-, we can state that, in general, the replacement of one carboxylate group by an amide group decreases the water-exchange rate of the gadolinium(III) complexes by a factor of about three to five. Gadolinium 83-85 general transcription factor IIH subunit 5 Homo sapiens 86-90 17512738-3 2007 The longitudinal proton relaxivities of the neutral [Gd-(Gal-PA-DO3A-NH2)] and [Gd-(Gal-DO3A)] complexes were increased by 28% and 37% in the presence of beta-galactosidase, respectively. Gadolinium 53-55 galactosidase beta 1 Homo sapiens 154-172 17512738-3 2007 The longitudinal proton relaxivities of the neutral [Gd-(Gal-PA-DO3A-NH2)] and [Gd-(Gal-DO3A)] complexes were increased by 28% and 37% in the presence of beta-galactosidase, respectively. Gadolinium 53-56 galactosidase beta 1 Homo sapiens 154-172 17592591-7 2007 In addition, to support the HSA protein binding studies of lipophilic [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] complexes, further protein-complex binding was studied by ultrafiltration and relaxivity studies. Gadolinium 71-73 general transcription factor IIH subunit 5 Homo sapiens 74-78 17592591-5 2007 On the basis of the water-exchange rate values available for [Gd(TTDA-BMA)(H2O)], [Gd(TTDA-BBA)(H2O)] and [Gd(TTDA-N-MOBA)(H2O)]-, we can state that, in general, the replacement of one carboxylate group by an amide group decreases the water-exchange rate of the gadolinium(III) complexes by a factor of about three to five. Gadolinium 83-85 general transcription factor IIH subunit 5 Homo sapiens 86-90 17592591-7 2007 In addition, to support the HSA protein binding studies of lipophilic [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] complexes, further protein-complex binding was studied by ultrafiltration and relaxivity studies. Gadolinium 99-101 general transcription factor IIH subunit 5 Homo sapiens 102-106 17592591-5 2007 On the basis of the water-exchange rate values available for [Gd(TTDA-BMA)(H2O)], [Gd(TTDA-BBA)(H2O)] and [Gd(TTDA-N-MOBA)(H2O)]-, we can state that, in general, the replacement of one carboxylate group by an amide group decreases the water-exchange rate of the gadolinium(III) complexes by a factor of about three to five. Gadolinium 83-85 general transcription factor IIH subunit 5 Homo sapiens 86-90 17592591-8 2007 The binding constants (KA) of [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] are 8.6 x 10(2) and 1.0 x 10(4) dm3 mol(-1), respectively. Gadolinium 31-33 general transcription factor IIH subunit 5 Homo sapiens 34-38 17592591-8 2007 The binding constants (KA) of [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] are 8.6 x 10(2) and 1.0 x 10(4) dm3 mol(-1), respectively. Gadolinium 31-33 general transcription factor IIH subunit 5 Homo sapiens 62-66 17592591-5 2007 On the basis of the water-exchange rate values available for [Gd(TTDA-BMA)(H2O)], [Gd(TTDA-BBA)(H2O)] and [Gd(TTDA-N-MOBA)(H2O)]-, we can state that, in general, the replacement of one carboxylate group by an amide group decreases the water-exchange rate of the gadolinium(III) complexes by a factor of about three to five. Gadolinium 83-85 general transcription factor IIH subunit 5 Homo sapiens 86-90 17592591-8 2007 The binding constants (KA) of [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] are 8.6 x 10(2) and 1.0 x 10(4) dm3 mol(-1), respectively. Gadolinium 59-61 general transcription factor IIH subunit 5 Homo sapiens 34-38 17592591-8 2007 The binding constants (KA) of [Gd(TTDA-N-MOBA)(H2O)]- and [Gd(TTDA-BBA)(H2O)] are 8.6 x 10(2) and 1.0 x 10(4) dm3 mol(-1), respectively. Gadolinium 59-61 general transcription factor IIH subunit 5 Homo sapiens 62-66 17592591-10 2007 The KA value of [Gd(TTDA-BBA)(H2O)] is similar to that of MS-325 and indicates a stronger interaction of [Gd(TTDA-BBA)(H2O)] with HSA. Gadolinium 17-19 general transcription factor IIH subunit 5 Homo sapiens 20-24 17592591-10 2007 The KA value of [Gd(TTDA-BBA)(H2O)] is similar to that of MS-325 and indicates a stronger interaction of [Gd(TTDA-BBA)(H2O)] with HSA. Gadolinium 17-19 general transcription factor IIH subunit 5 Homo sapiens 109-113 17581950-3 2007 Caspase 8 was activated in brain lesions after permanent middle cerebral artery occlusion (pMCAO) and in cortical neurons subjected to glucose deprivation (GD) and was necessary for GD-induced neuron death. Gadolinium 156-158 caspase 8 Mus musculus 0-9 17592591-10 2007 The KA value of [Gd(TTDA-BBA)(H2O)] is similar to that of MS-325 and indicates a stronger interaction of [Gd(TTDA-BBA)(H2O)] with HSA. Gadolinium 106-108 general transcription factor IIH subunit 5 Homo sapiens 20-24 17592591-10 2007 The KA value of [Gd(TTDA-BBA)(H2O)] is similar to that of MS-325 and indicates a stronger interaction of [Gd(TTDA-BBA)(H2O)] with HSA. Gadolinium 106-108 general transcription factor IIH subunit 5 Homo sapiens 109-113 17596195-0 2007 A high-threshold heat-activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium. Gadolinium 119-129 transient receptor potential cation channel, subfamily V, member 2 Rattus norvegicus 95-100 17596195-7 2007 In addition to a previously described block by ruthenium red, we identified the trivalent cations, lanthanum (La(3+)) and gadolinium (Gd(3+)) as potent blockers of TRPV2. Gadolinium 122-132 transient receptor potential cation channel, subfamily V, member 2 Rattus norvegicus 164-169 17433041-7 2007 Following recent reports of a possible causative role of gadolinium, we present two patients with histologically confirmed NSF/NFD, who had exposure to gadolinium-containing contrast agents 1-2 months before onset of disease. Gadolinium 152-162 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 123-126 17433041-8 2007 Severity of renal impairment, lack of immediate dialysis after exposure and cumulative dose of gadolinium are possible factors influencing the development of NSF/NFD. Gadolinium 95-105 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 158-161 17433041-9 2007 The process of transmetallation of gadolinium chelates may occur in patients with renal impairment, leading to precipitation of free gadolinium in the dermis or other organs, causing tissue injury that ultimately leads to the clinical manifestations of NSF/NFD. Gadolinium 35-45 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 253-256 17433041-9 2007 The process of transmetallation of gadolinium chelates may occur in patients with renal impairment, leading to precipitation of free gadolinium in the dermis or other organs, causing tissue injury that ultimately leads to the clinical manifestations of NSF/NFD. Gadolinium 133-143 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 253-256 17581950-5 2007 The presence of the neuroprotective TNFRI was necessary for selectively sustaining p50/p65NF-kappaB activity and the expression of the p43 cleavage form of FLIP(L), FLIP(p43), an endogenous inhibitor of caspase 8, in pMCAO lesions and GD-treated neurons. Gadolinium 235-237 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 Mus musculus 135-138 17581950-5 2007 The presence of the neuroprotective TNFRI was necessary for selectively sustaining p50/p65NF-kappaB activity and the expression of the p43 cleavage form of FLIP(L), FLIP(p43), an endogenous inhibitor of caspase 8, in pMCAO lesions and GD-treated neurons. Gadolinium 235-237 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 Mus musculus 170-173 17581950-7 2007 The knock-down of FLIP in wild-type (WT) neurons using a short hairpin RNA revealed that FLIP(L) is essential for TNF/TNFRI-mediated neuroprotection after GD. Gadolinium 155-157 tumor necrosis factor Mus musculus 114-117 17581950-7 2007 The knock-down of FLIP in wild-type (WT) neurons using a short hairpin RNA revealed that FLIP(L) is essential for TNF/TNFRI-mediated neuroprotection after GD. Gadolinium 155-157 tumor necrosis factor receptor superfamily, member 1a Mus musculus 118-123 17581950-4 2007 Thus, neurons treated with zIETD-FMK peptide or overexpressing a dominant-negative caspase 8 mutant were fully protected against GD-induced death. Gadolinium 129-131 caspase 8 Mus musculus 83-92 17581950-5 2007 The presence of the neuroprotective TNFRI was necessary for selectively sustaining p50/p65NF-kappaB activity and the expression of the p43 cleavage form of FLIP(L), FLIP(p43), an endogenous inhibitor of caspase 8, in pMCAO lesions and GD-treated neurons. Gadolinium 235-237 tumor necrosis factor receptor superfamily, member 1a Mus musculus 36-41 17441914-9 2007 Caution must now also be taken in these patients, given the recent studies raising the association of gadolinium-based compounds and NSF. Gadolinium 102-112 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 133-136 17497773-4 2007 In addition, this ligand is highly selective for Gd(III) binding in the presence of Zn(II) or Ca(II). Gadolinium 49-51 carbonic anhydrase 2 Homo sapiens 94-100 17535959-1 2007 Using the lanthanide gadolinium (Gd(3+)) as a Ca(2+) replacing probe, we investigated the voltage dependence of pore blockage of Ca(V)1.2 channels. Gadolinium 21-31 immunoglobulin lambda variable 2-8 Homo sapiens 129-137 17535960-1 2007 Lanthanide gadolinium (Gd(3+)) blocks Ca(V)1.2 channels at the selectivity filter. Gadolinium 11-21 immunoglobulin lambda variable 2-8 Homo sapiens 38-46 17469113-2 2007 One technique that has been used to investigate early OA is delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), where T1(Gd) (T1 value after penetration of the MRI contrast agent gadopentate dimeglumine [Gd-DTPA(2-)]) is used as an index of the molecular status of articular cartilage. Gadolinium 68-78 CD5 molecule Homo sapiens 145-151 17309078-9 2007 Thus, these results suggest that GD-induced cell death mode is determined by the protein kinase C/ERK1/2 signal pathway that regulates MnSOD and CuZnSOD and that these antioxidants may exert their known tumor suppressive activities by inducing necrosis-to-apoptosis switch. Gadolinium 33-35 mitogen-activated protein kinase 3 Homo sapiens 98-104 17309078-9 2007 Thus, these results suggest that GD-induced cell death mode is determined by the protein kinase C/ERK1/2 signal pathway that regulates MnSOD and CuZnSOD and that these antioxidants may exert their known tumor suppressive activities by inducing necrosis-to-apoptosis switch. Gadolinium 33-35 superoxide dismutase 2 Homo sapiens 135-140 17411099-2 2007 5 nm in diameter) bivalent paramagnetic nanoprobe for detecting cell death using magnetic resonance imaging (MRI) is described, in which two biotinylated C2A domains of the protein synaptotagmin-I were complexed with a single avidin molecule, which had been labeled with gadolinium chelates. Gadolinium 271-281 synaptotagmin 1 Homo sapiens 181-196 17445502-2 2007 The anti-ICAM-1 antibody was coupled with DTPA and was then conjugated with Gd. Gadolinium 76-78 intercellular adhesion molecule 1 Mus musculus 9-15 17332429-6 2007 GD-induced autophagy coincided with activation of AMP-activated protein kinase (AMPK) and inactivation of mTOR (mammalian target of rapamycin). Gadolinium 0-2 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 50-78 17332429-6 2007 GD-induced autophagy coincided with activation of AMP-activated protein kinase (AMPK) and inactivation of mTOR (mammalian target of rapamycin). Gadolinium 0-2 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 80-84 17332429-6 2007 GD-induced autophagy coincided with activation of AMP-activated protein kinase (AMPK) and inactivation of mTOR (mammalian target of rapamycin). Gadolinium 0-2 mechanistic target of rapamycin kinase Homo sapiens 106-110 17332429-6 2007 GD-induced autophagy coincided with activation of AMP-activated protein kinase (AMPK) and inactivation of mTOR (mammalian target of rapamycin). Gadolinium 0-2 mechanistic target of rapamycin kinase Homo sapiens 112-141 17332429-7 2007 Inhibition of AMPK by adenine 9-beta-d-arabinofuranoside or dominant negative AMPK significantly reduced GD-induced autophagy, whereas stimulation of autophagy by rapamycin failed to cause an additive effect on GD-induced autophagy, suggesting that activation of AMPK and inhibition of mTOR mediate GD-induced autophagy. Gadolinium 105-107 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 14-18 17332429-7 2007 Inhibition of AMPK by adenine 9-beta-d-arabinofuranoside or dominant negative AMPK significantly reduced GD-induced autophagy, whereas stimulation of autophagy by rapamycin failed to cause an additive effect on GD-induced autophagy, suggesting that activation of AMPK and inhibition of mTOR mediate GD-induced autophagy. Gadolinium 105-107 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 78-82 17332429-7 2007 Inhibition of AMPK by adenine 9-beta-d-arabinofuranoside or dominant negative AMPK significantly reduced GD-induced autophagy, whereas stimulation of autophagy by rapamycin failed to cause an additive effect on GD-induced autophagy, suggesting that activation of AMPK and inhibition of mTOR mediate GD-induced autophagy. Gadolinium 105-107 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 78-82 17332429-7 2007 Inhibition of AMPK by adenine 9-beta-d-arabinofuranoside or dominant negative AMPK significantly reduced GD-induced autophagy, whereas stimulation of autophagy by rapamycin failed to cause an additive effect on GD-induced autophagy, suggesting that activation of AMPK and inhibition of mTOR mediate GD-induced autophagy. Gadolinium 105-107 mechanistic target of rapamycin kinase Mus musculus 286-290 17332429-7 2007 Inhibition of AMPK by adenine 9-beta-d-arabinofuranoside or dominant negative AMPK significantly reduced GD-induced autophagy, whereas stimulation of autophagy by rapamycin failed to cause an additive effect on GD-induced autophagy, suggesting that activation of AMPK and inhibition of mTOR mediate GD-induced autophagy. Gadolinium 211-213 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 14-18 17332429-7 2007 Inhibition of AMPK by adenine 9-beta-d-arabinofuranoside or dominant negative AMPK significantly reduced GD-induced autophagy, whereas stimulation of autophagy by rapamycin failed to cause an additive effect on GD-induced autophagy, suggesting that activation of AMPK and inhibition of mTOR mediate GD-induced autophagy. Gadolinium 211-213 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 14-18 17204417-5 2007 The increase in VDR was also dose-dependently increased using 20-100 nM gadolinium, suggesting the induction of VDR is regulated via the extracellular Ca sensing receptor (CaSR) with is naturally expressed in HK-2G cells. Gadolinium 72-82 vitamin D receptor Homo sapiens 16-19 17204417-5 2007 The increase in VDR was also dose-dependently increased using 20-100 nM gadolinium, suggesting the induction of VDR is regulated via the extracellular Ca sensing receptor (CaSR) with is naturally expressed in HK-2G cells. Gadolinium 72-82 vitamin D receptor Homo sapiens 112-115 17425865-1 2007 OBJECTIVE: To study invasively imaging MMP2-positive tumor cell by paramagnetic Gadolinium or fluorescein carried by a activable cell penetrating peptides. Gadolinium 80-90 matrix metallopeptidase 2 Homo sapiens 39-43 17185001-8 2007 Gadolinium-based active staining demonstrated that layers of the hippocampus were disorganized in Reln(rl/rl) mice and differences in thickness of these layers were identified between WT and Reln(rl/rl) mice. Gadolinium 0-10 reelin Mus musculus 98-102 17185001-8 2007 Gadolinium-based active staining demonstrated that layers of the hippocampus were disorganized in Reln(rl/rl) mice and differences in thickness of these layers were identified between WT and Reln(rl/rl) mice. Gadolinium 0-10 reelin Mus musculus 191-195 17204104-8 2007 As a result of magnetic resonance imaging with gadolinium enhancement, bilateral vestibular schwannomas were detected and a final diagnosis of NF2 was thus made. Gadolinium 47-57 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 143-146 17310098-2 2007 Stimulation of CaSR with divalent cations or the potent agonist Gd(3+) leads to activation of the H(+)/K(+)-ATPase and subsequently to gastric acid secretion. Gadolinium 64-66 calcium sensing receptor Homo sapiens 15-19 17310098-9 2007 Chelerythrine, a general inhibitor of protein kinase C, and Go 6976 which selectively inhibits Ca(2+)-dependent PKC(alpha) and PKC(betaI)-isozymes completely abolished the stimulatory effect of Gd(3+). Gadolinium 194-196 proline rich transmembrane protein 2 Homo sapiens 127-137 17109993-1 2007 There is growing recognition of the association between the use of gadolinium-containing radiocontrast agents for magnetic resonance imaging and the serious dermal and systemic disease nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis (NFD/NSF). Gadolinium 67-77 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 253-256 17891611-2 2007 The aim of the present study was to correlate infarct size and left ventricular function determined by cine and late gadolinium enhanced CMR with plasma levels of TNT and NT-pro BNP levels after AMI. Gadolinium 117-127 troponin T1, slow skeletal type Homo sapiens 163-166 17089381-0 2006 Gadolinium mixed-micelles: effect of the amphiphile on in vitro and in vivo efficacy in apolipoprotein E knockout mouse models of atherosclerosis. Gadolinium 0-10 apolipoprotein E Mus musculus 88-104 17018578-0 2007 Motexafin gadolinium-induced cell death correlates with heme oxygenase-1 expression and inhibition of P450 reductase-dependent activities. Gadolinium 10-20 heme oxygenase 1 Homo sapiens 56-72 17185669-4 2007 Three independent readers retrospectively reviewed the two sets of MR images (one set of gadolinium-enhanced 3D fast SPGR images and one set of routine T1-, T2-, and intermediate-weighted images). Gadolinium 89-99 glutathione S-transferase omega 1 Homo sapiens 117-121 17185669-15 2007 CONCLUSION: In the assessment of chronic syndesmosis injury, coronal gadolinium-enhanced fat-suppressed 3D fast SPGR MR images were more sensitive, specific, and accurate than routine MR images. Gadolinium 69-79 glutathione S-transferase omega 1 Homo sapiens 112-116 17142754-5 2006 Microglial LPC-induced IL-1beta release was suppressed in Ca(2+)-free medium or during inhibition of nonselective cation channels with Gd(3+) or La(3+). Gadolinium 135-137 interleukin 1 beta Homo sapiens 23-31 17089381-7 2006 Significant wall enhancement of ApoE(-/-) mice was observed following administration of 0.015 and 0.038 mmol Gd/kg of both micelle formulations. Gadolinium 109-111 apolipoprotein E Mus musculus 32-36 17060599-0 2006 Intrathecal gadolinium-enhanced magnetic resonance myelography in the detection of CSF leak. Gadolinium 12-22 colony stimulating factor 2 Homo sapiens 83-86 17081403-4 2006 RESULTS: CaSR protein was detected in rat cardiac tissue and CaSR activator gadolinium (GdCl3) induced cardiomyocyte apoptosis and increased ERK1/2 phosphorylation and expression of BCl2 and activated Caspase3. Gadolinium 76-86 calcium-sensing receptor Rattus norvegicus 9-13 16982763-0 2006 Magnetic resonance visualization of tumor angiogenesis by targeting neural cell adhesion molecules with the highly sensitive gadolinium-loaded apoferritin probe. Gadolinium 125-135 ferritin heavy chain 1 Homo sapiens 143-154 17193697-8 2006 To demonstrate the platform"s utility, we describe the preparation of five small molecule derivatives specific for prostate-specific membrane antigen (PSMA): a gadolinium derivative for MRI, indium, rhenium and technetium derivatives for SPECT, and an yttrium derivative for radiotherapy. Gadolinium 160-170 folate hydrolase 1 Homo sapiens 151-155 17025673-3 2006 The effects of concentration of gadolinium ions Gd3+ on DPPC unilamellar vesicles in aqueous media were studied by different techniques. Gadolinium 32-42 GRDX Homo sapiens 48-51 16763162-4 2006 During applied voltage ramps, VEGF activated a current that reversed at 0 mV, was sensitive to gadolinium, and required extracellular cations. Gadolinium 95-105 vascular endothelial growth factor A Homo sapiens 30-34 16806498-4 2006 We report here that the concentration of soluble VAP-1 in serum is significantly higher in multiple sclerosis patients with ongoing inflammatory activity, as demonstrated by gadolinium-enhancing MRI lesions, when compared to patients with no gadolinium-enhancing lesions (555+/-195 vs. 388+/-102 ng/ml, p=0.0068). Gadolinium 174-184 amine oxidase copper containing 3 Homo sapiens 49-54 16806498-4 2006 We report here that the concentration of soluble VAP-1 in serum is significantly higher in multiple sclerosis patients with ongoing inflammatory activity, as demonstrated by gadolinium-enhancing MRI lesions, when compared to patients with no gadolinium-enhancing lesions (555+/-195 vs. 388+/-102 ng/ml, p=0.0068). Gadolinium 242-252 amine oxidase copper containing 3 Homo sapiens 49-54 17081403-4 2006 RESULTS: CaSR protein was detected in rat cardiac tissue and CaSR activator gadolinium (GdCl3) induced cardiomyocyte apoptosis and increased ERK1/2 phosphorylation and expression of BCl2 and activated Caspase3. Gadolinium 76-86 calcium-sensing receptor Rattus norvegicus 61-65 17081403-4 2006 RESULTS: CaSR protein was detected in rat cardiac tissue and CaSR activator gadolinium (GdCl3) induced cardiomyocyte apoptosis and increased ERK1/2 phosphorylation and expression of BCl2 and activated Caspase3. Gadolinium 76-86 mitogen activated protein kinase 3 Rattus norvegicus 141-147 17081403-4 2006 RESULTS: CaSR protein was detected in rat cardiac tissue and CaSR activator gadolinium (GdCl3) induced cardiomyocyte apoptosis and increased ERK1/2 phosphorylation and expression of BCl2 and activated Caspase3. Gadolinium 76-86 BCL2, apoptosis regulator Rattus norvegicus 182-186 17081403-4 2006 RESULTS: CaSR protein was detected in rat cardiac tissue and CaSR activator gadolinium (GdCl3) induced cardiomyocyte apoptosis and increased ERK1/2 phosphorylation and expression of BCl2 and activated Caspase3. Gadolinium 76-86 caspase 3 Rattus norvegicus 201-209 17081403-5 2006 The selective mitogen-activated protein kinase (MAPK) inhibitor PD98059 abolished gadolinium -induced ERK1/2 activation and BCl2 expression, further increased the activation of Caspase3 and cardiomyocyte apoptosis. Gadolinium 82-92 mitogen activated protein kinase 3 Rattus norvegicus 48-52 17081403-5 2006 The selective mitogen-activated protein kinase (MAPK) inhibitor PD98059 abolished gadolinium -induced ERK1/2 activation and BCl2 expression, further increased the activation of Caspase3 and cardiomyocyte apoptosis. Gadolinium 82-92 mitogen activated protein kinase 3 Rattus norvegicus 102-108 17081403-5 2006 The selective mitogen-activated protein kinase (MAPK) inhibitor PD98059 abolished gadolinium -induced ERK1/2 activation and BCl2 expression, further increased the activation of Caspase3 and cardiomyocyte apoptosis. Gadolinium 82-92 BCL2, apoptosis regulator Rattus norvegicus 124-128 17081403-5 2006 The selective mitogen-activated protein kinase (MAPK) inhibitor PD98059 abolished gadolinium -induced ERK1/2 activation and BCl2 expression, further increased the activation of Caspase3 and cardiomyocyte apoptosis. Gadolinium 82-92 caspase 3 Rattus norvegicus 177-185 17081403-6 2006 CONCLUSION: Our results demonstrate the CaSR existence in cardiomyocytes and CaSR activation by gadolinium can induce myocyte apoptosis by activating Caspase3 and tyrosine protein kinase pathway. Gadolinium 96-106 calcium-sensing receptor Rattus norvegicus 40-44 17081403-6 2006 CONCLUSION: Our results demonstrate the CaSR existence in cardiomyocytes and CaSR activation by gadolinium can induce myocyte apoptosis by activating Caspase3 and tyrosine protein kinase pathway. Gadolinium 96-106 calcium-sensing receptor Rattus norvegicus 77-81 17081403-6 2006 CONCLUSION: Our results demonstrate the CaSR existence in cardiomyocytes and CaSR activation by gadolinium can induce myocyte apoptosis by activating Caspase3 and tyrosine protein kinase pathway. Gadolinium 96-106 caspase 3 Rattus norvegicus 150-158 16817324-8 2006 Overexpression of Hsp70-K71 E and -381-640 prevented the decrease in state III respiration observed at 5 hours, and all 3 prevented the increase in state IV respiration found in LXSN controls after 5 hours of GD. Gadolinium 209-211 heat shock protein family A (Hsp70) member 4 Homo sapiens 18-23 16729291-2 2006 Evidence for the anti-inflammatory effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors within the central nervous system arose from studies demonstrating that statins improve clinical signs in the animal model of MS and reduce the number of gadolinium-enhancing lesions in MS. METHODS: We sought to describe the impact of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor treatment on the physiology and immunology of human BBB-derived endothelial cells (ECs). Gadolinium 259-269 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 46-93 16490783-6 2006 Furthermore, both oxoM-induced NF-kappaB activation and sAPPalpha release were antagonized by CCE inhibitors (gadolinium or SKF96365) but not by voltage-gated Ca2+-channel blockers. Gadolinium 110-120 nuclear factor kappa B subunit 1 Homo sapiens 31-40 16770456-2 2006 In the crystal structure of 1 the gadolinium ions are bridged by carboxylate groups to dimers with a Gd3+ -Gd3+ distance of 420.2(3) pm. Gadolinium 34-44 GRDX Homo sapiens 101-104 16770456-2 2006 In the crystal structure of 1 the gadolinium ions are bridged by carboxylate groups to dimers with a Gd3+ -Gd3+ distance of 420.2(3) pm. Gadolinium 34-44 GRDX Homo sapiens 107-110 16458937-5 2006 Application of Gd(3+), a potent SA channel blocker, and depletion of external Ca(2+) exclusively inhibited the first peaks of eNOS and Akt activity, but exerted little effect on the second peak. Gadolinium 15-17 nitric oxide synthase 3 Bos taurus 126-130 16458937-5 2006 Application of Gd(3+), a potent SA channel blocker, and depletion of external Ca(2+) exclusively inhibited the first peaks of eNOS and Akt activity, but exerted little effect on the second peak. Gadolinium 15-17 AKT serine/threonine kinase 1 Bos taurus 135-138 16439673-8 2006 The antidipsogenic effects of 4alpha-PDD were blocked by preinjection into the ventricle of TRPV4 antagonists such as ruthenium red or gadolinium. Gadolinium 135-145 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 92-97 16688334-2 2006 With an ultimate goal of non-invasive imaging of MPO we used a gadolinium-chelating bis(5-hydroxytrytamide) derivative of diethylenetetraamine pentaacetic acid (L1-Gd3+ salt) as a paramagnetic sensor of enzymatic activity. Gadolinium 63-73 myeloperoxidase Homo sapiens 49-52 16707614-1 2006 PURPOSE: To determine if the tumor-targeted cytotoxin interleukin 13 bound to Pseudomonas exotoxin (IL13-PE) could be delivered to the brainstem safely at therapeutic doses while monitoring its distribution in real-time using a surrogate magnetic resonance imaging tracer, we used convection-enhanced delivery to perfuse rat and primate brainstems with IL13-PE and gadolinium-bound albumin (Gd-albumin). Gadolinium 365-375 interleukin 13 Rattus norvegicus 54-68 16707614-1 2006 PURPOSE: To determine if the tumor-targeted cytotoxin interleukin 13 bound to Pseudomonas exotoxin (IL13-PE) could be delivered to the brainstem safely at therapeutic doses while monitoring its distribution in real-time using a surrogate magnetic resonance imaging tracer, we used convection-enhanced delivery to perfuse rat and primate brainstems with IL13-PE and gadolinium-bound albumin (Gd-albumin). Gadolinium 365-375 interleukin 13 Rattus norvegicus 100-104 16820095-4 2006 Amphiphilic gadolinium (Gd)-diethylenetriaminepentaacetic acid chelates have been incorporated into the LDL to produce a novel LDLR-targeted magnetic resonance imaging (MRI) contrast agent. Gadolinium 12-22 low density lipoprotein receptor Homo sapiens 127-131 16820095-4 2006 Amphiphilic gadolinium (Gd)-diethylenetriaminepentaacetic acid chelates have been incorporated into the LDL to produce a novel LDLR-targeted magnetic resonance imaging (MRI) contrast agent. Gadolinium 24-26 low density lipoprotein receptor Homo sapiens 127-131 16820095-7 2006 In addition, Gd-labeled LDL retained selective cellular binding and uptake through LDLR-mediated endocytosis. Gadolinium 13-15 low density lipoprotein receptor Homo sapiens 83-87 16682671-5 2006 RESULTS: Significant, although weak to moderate, correlations were found between T2 BOD and age at disease onset, disease duration, disease course, disability (as measured by the Expanded Disability Status Scale [EDSS]), relapse rate, certain presenting symptoms, and gadolinium enhancement. Gadolinium 268-278 solute carrier family 25 member 5 Homo sapiens 81-83 16522730-0 2006 Inactivation of Kupffer cells by gadolinium administration prevents lipopolysaccharide-induced decrease in liver insulin-like growth factor-I and IGF-binding protein-3 gene expression. Gadolinium 33-43 insulin-like growth factor 1 Rattus norvegicus 113-141 16293679-9 2006 The current evoked by IL-1beta was also abolished by 100 microM gadolinium (Gd3+), but was significantly larger when examined in cells preshrunk by negative pressure applied via the recording pipette. Gadolinium 64-74 interleukin 1 beta Rattus norvegicus 22-30 16632615-2 2006 Acute adverse reactions to intravenous gadolinium-based contrast media used for MRI at the Princess Margaret Hospital, Hong Kong, SAR, from January 1999 to November 2004 were recorded in an incidence log book. Gadolinium 39-49 sarcosine dehydrogenase Homo sapiens 130-133 16484349-11 2006 CONCLUSION: Study results indicate that pre- and postcontrast imaging is necessary for delayed gadolinium-enhanced MR imaging evaluation of reparative cartilage after ACI. Gadolinium 95-105 CD1b molecule Homo sapiens 40-43 16630075-7 2006 The epidermal growth factor (EGF) receptor kinase inhibitor, AG1478, and calcium channel inhibitor, gadolinium (Gd3+), also inhibited Akt activation. Gadolinium 100-110 AKT serine/threonine kinase 1 Homo sapiens 134-137 16539394-10 2006 In particular, the piperidine backboned chelates Gd(PIP-DTPA) and Gd(PIP-DOTA) displayed reduced kidney retention as compared to the nonspecific MRI contrast agent Gd(DOTA) at all time points, although the observed effects were relatively small at 0.5 h postinjection. Gadolinium 49-51 prolactin induced protein Homo sapiens 52-55 16539394-10 2006 In particular, the piperidine backboned chelates Gd(PIP-DTPA) and Gd(PIP-DOTA) displayed reduced kidney retention as compared to the nonspecific MRI contrast agent Gd(DOTA) at all time points, although the observed effects were relatively small at 0.5 h postinjection. Gadolinium 66-68 prolactin induced protein Homo sapiens 69-72 16539394-10 2006 In particular, the piperidine backboned chelates Gd(PIP-DTPA) and Gd(PIP-DOTA) displayed reduced kidney retention as compared to the nonspecific MRI contrast agent Gd(DOTA) at all time points, although the observed effects were relatively small at 0.5 h postinjection. Gadolinium 66-68 prolactin induced protein Homo sapiens 69-72 16514440-1 2006 Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules. Gadolinium 139-141 complement C4A (Rodgers blood group) Homo sapiens 12-15 16522730-0 2006 Inactivation of Kupffer cells by gadolinium administration prevents lipopolysaccharide-induced decrease in liver insulin-like growth factor-I and IGF-binding protein-3 gene expression. Gadolinium 33-43 insulin-like growth factor binding protein 3 Rattus norvegicus 146-167 16390062-5 2006 Fluorescent probe displacement studies exhibit that [Gd(TTDA-BOM)(H(2)O)](2-) and [Gd(TTDA-N"-BOM)(H(2)O)](2-) can displace dansylsarcosine from HSA with inhibition constants (K(i)) of 1900 and 1600 microM, respectively; however, they are not able to displace warfarin. Gadolinium 53-55 general transcription factor IIH subunit 5 Homo sapiens 56-60 16542137-1 2006 In a phase II trial in relapsing-remitting multiple sclerosis (RRMS), patients ingesting 10,000 IU, but not 30,000 IU, interferon-alpha (IFN-alpha) showed fewer gadolinium enhancements at months 5 and 6, along with decreased proinflammatory tumor necrosis factor-alpha (TNF-alpha) protein secretion. Gadolinium 161-171 interferon alpha 1 Homo sapiens 137-146 16390062-6 2006 These results indicate that [Gd(TTDA-BOM)(H(2)O)](2-) and [Gd(TTDA-N"-BOM)(H(2)O)](2-) have a weak binding to site II on HSA. Gadolinium 29-31 general transcription factor IIH subunit 5 Homo sapiens 32-36 16565933-10 2006 The CD4+ relative percentage was significantly higher both in the total as well as in gadolinium positive and negative subgroups. Gadolinium 86-96 CD4 molecule Homo sapiens 4-7 16317488-2 2006 HCC-to-liver contrast-to-noise ratio correlated with VEGF expression index (VEGF(IND)) values of HCCs inversely on opposed-phase, T1-weighted, spoiled gradient recalled-echo (GRE) images, directly on T2-weighted, fast spin-echo images, and marginally and inversely on gadolinium-enhanced hepatic arterial-phase GRE images. Gadolinium 268-278 holocytochrome c synthase Homo sapiens 97-101 16565933-12 2006 The absolute number of CD4 lymphocytes was the lowest in gadolinium negative MS cases. Gadolinium 57-67 CD4 molecule Homo sapiens 23-26 16099171-0 2005 Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites. Gadolinium 0-10 transient receptor potential cation channel subfamily V member 1 Homo sapiens 59-64 16319142-11 2005 Treatment of C2C12 myoblasts with gadolinium ions prevented differentiation-associated cell death and inhibited the cleavage of poly (ADP-ribose) polymerase and activation of caspase-3. Gadolinium 34-44 poly(ADP-ribose) polymerase 1 Homo sapiens 128-156 16319142-11 2005 Treatment of C2C12 myoblasts with gadolinium ions prevented differentiation-associated cell death and inhibited the cleavage of poly (ADP-ribose) polymerase and activation of caspase-3. Gadolinium 34-44 caspase 3 Homo sapiens 175-184 16319142-12 2005 On the other hand, delivery of active caspase-3 protein to C2C12 myoblasts reversed the inhibitory effect of gadolinium ions on myogenesis. Gadolinium 109-119 caspase 3 Homo sapiens 38-47 16893669-8 2006 Ca(2+)-free extracellular medium (containing 0.5mM EGTA) and the use of gadolinium (5 microM), which suppressed MSACI, prevented ERK 1/2 and p38 phosphorylation by ATP. Gadolinium 72-82 mitogen-activated protein kinase 3 Homo sapiens 129-136 16893669-8 2006 Ca(2+)-free extracellular medium (containing 0.5mM EGTA) and the use of gadolinium (5 microM), which suppressed MSACI, prevented ERK 1/2 and p38 phosphorylation by ATP. Gadolinium 72-82 mitogen-activated protein kinase 1 Homo sapiens 141-144 16199532-5 2005 In addition, calcium, magnesium, strontium, aluminum, gadolinium, and the calcimimetic NPS 568 resulted in a dose-dependent stimulation of GPRC6A overexpressed in human embryonic kidney cells 293 cells. Gadolinium 54-64 G protein-coupled receptor class C group 6 member A Homo sapiens 139-145 16099171-2 2005 In this study, we demonstrate that Gd(3+), in addition to its blocking effects, activates and potentiates the recombinant vanilloid receptor TRPV1 expressed in HEK293T cells. Gadolinium 35-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 141-146 16225179-6 2005 In both cases brain MRI showed a lesion in the SCC characterized by high signal on T2-weighted images and no enhancement after Gadolinium infusion. Gadolinium 127-137 serpin family B member 3 Homo sapiens 47-50 16159278-0 2005 A gadolinium chelate for detection of beta-glucuronidase: a self-immolative approach. Gadolinium 2-12 beta-glucuronidase Bos taurus 38-56 15890751-12 2005 Gadolinium, a mechanosensitive calcium channel blocker, blocked strain-induced ROS production and p42/44 MAP kinase phosphorylation but not strain-induced tyrosine phosphorylation. Gadolinium 0-10 cyclin dependent kinase 20 Homo sapiens 98-101 15963050-5 2005 Treatment of bone marrow-derived DCs with GD(3) before lipopolysaccharide-induced maturation decreased the production of interleukin-6 (IL-6), IL-10, IL-12 and tumor necrosis factor-alpha as well as reduced the alloreactivity in mixed leucocyte reaction (MLR). Gadolinium 42-44 interleukin 6 Homo sapiens 121-134 15963050-5 2005 Treatment of bone marrow-derived DCs with GD(3) before lipopolysaccharide-induced maturation decreased the production of interleukin-6 (IL-6), IL-10, IL-12 and tumor necrosis factor-alpha as well as reduced the alloreactivity in mixed leucocyte reaction (MLR). Gadolinium 42-44 interleukin 6 Homo sapiens 136-140 15963050-5 2005 Treatment of bone marrow-derived DCs with GD(3) before lipopolysaccharide-induced maturation decreased the production of interleukin-6 (IL-6), IL-10, IL-12 and tumor necrosis factor-alpha as well as reduced the alloreactivity in mixed leucocyte reaction (MLR). Gadolinium 42-44 interleukin 10 Homo sapiens 143-148 15963050-5 2005 Treatment of bone marrow-derived DCs with GD(3) before lipopolysaccharide-induced maturation decreased the production of interleukin-6 (IL-6), IL-10, IL-12 and tumor necrosis factor-alpha as well as reduced the alloreactivity in mixed leucocyte reaction (MLR). Gadolinium 42-44 tumor necrosis factor Homo sapiens 150-187 16176066-7 2005 When blood vessels were washed out with saline perfusion brain CAT activity significantly increased up to 6 h after trauma, decreasing significantly by 24 h; GAD or AMI administration preserved CAT activity 24 h after TBI. Gadolinium 158-161 catalase Rattus norvegicus 194-197 15840777-6 2005 Moreover, gadolinium (an S-A channel inhibitor), but not nifedipine (L-Type Ca2+ channel blocker), treatment reduced the concentration of VEGF and M-CSF mRNA and protein in the experimental groups. Gadolinium 10-20 vascular endothelial growth factor A Mus musculus 138-142 15840777-6 2005 Moreover, gadolinium (an S-A channel inhibitor), but not nifedipine (L-Type Ca2+ channel blocker), treatment reduced the concentration of VEGF and M-CSF mRNA and protein in the experimental groups. Gadolinium 10-20 colony stimulating factor 1 (macrophage) Mus musculus 147-152 15843607-6 2005 First, TRPA1 and the hair cell transducer share a unique set of pore properties not described for any other channel (block by gadolinium, amiloride, gentamicin, and ruthenium red, a ranging conductance of approximately 100 pS that is reduced to 54% by calcium, permeating calcium-induced potentiation followed by closure, and reopening by depolarization), supporting a direct role of TRPA1 as a pore-forming subunit of the hair cell transducer. Gadolinium 126-136 transient receptor potential cation channel subfamily A member 1 Homo sapiens 7-12 15946910-8 2005 According to this surrogate marker of renal function, the change of estimated GFR in patients with normal baseline renal function was not significant, while in patients with impaired renal function, GFR increased after the administration of gadolinium (p < 0.001). Gadolinium 241-251 Rap guanine nucleotide exchange factor 5 Homo sapiens 199-202 15767456-4 2005 The HVEM/gD/gH complex was detected with mild or stringent cell lysis conditions. Gadolinium 9-11 TNF receptor superfamily member 14 Homo sapiens 4-8 15824364-4 2005 An unusual MRI appearance with CSF hyperintensity due to gadolinium diffusion into the CSF is also shown. Gadolinium 57-67 colony stimulating factor 2 Homo sapiens 31-34 15824364-4 2005 An unusual MRI appearance with CSF hyperintensity due to gadolinium diffusion into the CSF is also shown. Gadolinium 57-67 colony stimulating factor 2 Homo sapiens 87-90 15771964-2 2005 Current insights suggest that the fusion process is initiated by interaction of gD with a cognate cellular receptor, such as the widely distributed cell adhesion molecule nectin-1. Gadolinium 80-82 nectin cell adhesion molecule 1 Homo sapiens 171-179 16008259-10 2005 RESULTS: VEGF induced significant Gd uptake in the scala tympani and scala vestibuli, but had little effect on the uptake of Gd in the scala media. Gadolinium 34-36 Vegfa Cavia porcellus 9-13 15771964-3 2005 To redirect the tropism of HSV-1, we have generated a soluble adapter protein (P-V528LH) comprising the gD-binding variable domain of nectin-1 fused to a single-chain antibody (528LH) recognizing the EGF receptor. Gadolinium 104-106 nectin-1 Cricetulus griseus 134-142 15590129-8 2005 Both gadolinium and FB1 treatments individually increased the expression of selected cell signal factors; e.g., TNFalpha, TNF receptor 1, TNF-related apoptosis-inducing ligand, lymphotoxin beta, interferon gamma, and transforming growth factor beta1; gadolinium chloride did not alter FB1-induced expression of the above genes. Gadolinium 5-15 tumor necrosis factor Mus musculus 112-120 15728605-1 2005 OBJECTIVE: The purpose of our study was to assess the correlation between the quantitative and qualitative imaging findings on unenhanced and gadolinium-enhanced MR images and the intensity of vascular endothelial growth factor (VEGF) expression in hepatocellular carcinomas and in the surrounding nontumorous liver. Gadolinium 142-152 vascular endothelial growth factor A Homo sapiens 193-227 15728605-1 2005 OBJECTIVE: The purpose of our study was to assess the correlation between the quantitative and qualitative imaging findings on unenhanced and gadolinium-enhanced MR images and the intensity of vascular endothelial growth factor (VEGF) expression in hepatocellular carcinomas and in the surrounding nontumorous liver. Gadolinium 142-152 vascular endothelial growth factor A Homo sapiens 229-233 15709146-1 2005 When squamous cell carcinoma (SCC) involves the palatine tonsils, they are generally enlarged and demonstrate intermediate to high signal intensity on T2-weighted MR images and enhance after gadolinium administration. Gadolinium 191-201 serpin family B member 3 Homo sapiens 30-33 15590129-8 2005 Both gadolinium and FB1 treatments individually increased the expression of selected cell signal factors; e.g., TNFalpha, TNF receptor 1, TNF-related apoptosis-inducing ligand, lymphotoxin beta, interferon gamma, and transforming growth factor beta1; gadolinium chloride did not alter FB1-induced expression of the above genes. Gadolinium 5-15 tumor necrosis factor (ligand) superfamily, member 10 Mus musculus 138-175 15590129-8 2005 Both gadolinium and FB1 treatments individually increased the expression of selected cell signal factors; e.g., TNFalpha, TNF receptor 1, TNF-related apoptosis-inducing ligand, lymphotoxin beta, interferon gamma, and transforming growth factor beta1; gadolinium chloride did not alter FB1-induced expression of the above genes. Gadolinium 5-15 lymphotoxin B Mus musculus 177-193 15590129-8 2005 Both gadolinium and FB1 treatments individually increased the expression of selected cell signal factors; e.g., TNFalpha, TNF receptor 1, TNF-related apoptosis-inducing ligand, lymphotoxin beta, interferon gamma, and transforming growth factor beta1; gadolinium chloride did not alter FB1-induced expression of the above genes. Gadolinium 5-15 interferon gamma Mus musculus 195-249 15651905-3 2005 These results were supported by MRI findings that showed significantly smaller increases in the volume of brain lesions and the number of new/enlarging and gadolinium-enhancing lesions in interferon-beta-1a recipients than in those receiving placebo. Gadolinium 156-166 interferon beta 1 Homo sapiens 188-203 15689102-6 2004 With the total concentration of Gd(III) further rising, [Gd3(OH)4] begins to appear and gradually becomes a predominant species. Gadolinium 32-34 GRDX Homo sapiens 57-60 15654884-1 2005 The effect of gadolinium ions on the sarcoplasmic reticulum (SR) calcium release channel/ryanodine receptor (RyR1) was studied using heavy SR (HSR) vesicles and RyR1 isolated from rabbit fast twitch muscle. Gadolinium 14-24 ryanodine receptor 1 Oryctolagus cuniculus 109-113 15356186-11 2005 The ANG II current reversed polarity at +2.2 +/- 2.2 mV (n = 9) and was blocked (P < 0.01) by bath perfusion with gadolinium (Gd(3+), 100 muM, n = 8), suggesting that ANG II activates membrane channels that are nonselectively permeable to cations. Gadolinium 117-127 angiotensinogen Rattus norvegicus 4-10 15356186-11 2005 The ANG II current reversed polarity at +2.2 +/- 2.2 mV (n = 9) and was blocked (P < 0.01) by bath perfusion with gadolinium (Gd(3+), 100 muM, n = 8), suggesting that ANG II activates membrane channels that are nonselectively permeable to cations. Gadolinium 117-127 angiotensinogen Rattus norvegicus 170-176 15678762-1 2004 We report a characteristic finding in gadolinium-enhanced magnetic resonance images (MRIs) of the central nervous system (CNS) in a 61-year-old man with a homozygous transthyretin (TTR) Val30Met mutation. Gadolinium 38-48 transthyretin Homo sapiens 181-184 15678762-4 2004 In the gadolinium-enhanced T1-weighted MRIs of the brain and spinal cord, leptomeningeal enhancement was seen along the surfaces of the brain stem and more clearly in the spinal cord, suggesting leptomeningeal TTR-related amyloid deposition. Gadolinium 7-17 transthyretin Homo sapiens 210-213 15531043-3 2004 Co-administration of gD with IL-12 resulted in gD-specific antibody subclass switching from predominantly IgG1 observed in mice immunized with either gD or gD/AlPO4 to a more balanced combination of IgG1 and IgG2a, and enhanced virus neutralizing activity. Gadolinium 21-23 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 106-110 15531043-3 2004 Co-administration of gD with IL-12 resulted in gD-specific antibody subclass switching from predominantly IgG1 observed in mice immunized with either gD or gD/AlPO4 to a more balanced combination of IgG1 and IgG2a, and enhanced virus neutralizing activity. Gadolinium 21-23 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 199-203 15531043-3 2004 Co-administration of gD with IL-12 resulted in gD-specific antibody subclass switching from predominantly IgG1 observed in mice immunized with either gD or gD/AlPO4 to a more balanced combination of IgG1 and IgG2a, and enhanced virus neutralizing activity. Gadolinium 21-23 immunoglobulin heavy variable V1-9 Mus musculus 208-213 15531043-3 2004 Co-administration of gD with IL-12 resulted in gD-specific antibody subclass switching from predominantly IgG1 observed in mice immunized with either gD or gD/AlPO4 to a more balanced combination of IgG1 and IgG2a, and enhanced virus neutralizing activity. Gadolinium 47-49 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 106-110 15531043-3 2004 Co-administration of gD with IL-12 resulted in gD-specific antibody subclass switching from predominantly IgG1 observed in mice immunized with either gD or gD/AlPO4 to a more balanced combination of IgG1 and IgG2a, and enhanced virus neutralizing activity. Gadolinium 47-49 immunoglobulin heavy variable V1-9 Mus musculus 208-213 15505162-12 2004 CONCLUSIONS: CSF nitrite and nitrate levels were increased in mildly disabled patients with MS and found to correlate with the volume of Gd-enhanced lesions on MRI. Gadolinium 137-139 colony stimulating factor 2 Homo sapiens 13-16 15446878-2 2004 The present work describes the design, synthesis, and evaluation of a novel Mn(II) complex (MnL1) based on EDTA and also contains a moiety that noncovalently binds the complex to serum albumin, the same moiety used in the gadolinium based contrast agent MS-325. Gadolinium 222-232 albumin Oryctolagus cuniculus 179-192 15342207-4 2004 Moreover, OPN protein levels were significantly elevated 1 month prior to increase of gadolinium (Gd)-enhancing lesion number, whereas no relation was observed between OPN levels and increase in Gd-enhancing lesion volume. Gadolinium 86-96 secreted phosphoprotein 1 Homo sapiens 10-13 15342207-4 2004 Moreover, OPN protein levels were significantly elevated 1 month prior to increase of gadolinium (Gd)-enhancing lesion number, whereas no relation was observed between OPN levels and increase in Gd-enhancing lesion volume. Gadolinium 98-100 secreted phosphoprotein 1 Homo sapiens 10-13 15254149-4 2004 In addition, and in the absence of receptor stimulation, extracellular gadolinium (0.1 mm) activated TRPC5, an effect that was mimicked by 5-20 mm extracellular Ca2+ with intracellular Ca2+ buffered. Gadolinium 71-81 transient receptor potential cation channel subfamily C member 5 Homo sapiens 101-106 16134003-4 2004 As a result, GD (0.01 mg/mL)-containing medium in stimulated culture supernatants increased IL-2 and IFN-gamma, and decreased IL-4 secretion in MOLT-4. Gadolinium 13-15 interleukin 2 Homo sapiens 92-96 16134003-4 2004 As a result, GD (0.01 mg/mL)-containing medium in stimulated culture supernatants increased IL-2 and IFN-gamma, and decreased IL-4 secretion in MOLT-4. Gadolinium 13-15 interferon gamma Homo sapiens 101-110 16134003-4 2004 As a result, GD (0.01 mg/mL)-containing medium in stimulated culture supernatants increased IL-2 and IFN-gamma, and decreased IL-4 secretion in MOLT-4. Gadolinium 13-15 interleukin 4 Homo sapiens 126-130 16134003-5 2004 GD (0.01-1 mg/mL)-containing medium in stimulated culture supernatants dose-dependently and significantly decreased IL-8, IL-13, and tumor necrosis factor-alpha secretion on the phorbol 12-myristate 13-acetate and A23187-stimulated HMC-1. Gadolinium 0-2 C-X-C motif chemokine ligand 8 Homo sapiens 116-120 16134003-5 2004 GD (0.01-1 mg/mL)-containing medium in stimulated culture supernatants dose-dependently and significantly decreased IL-8, IL-13, and tumor necrosis factor-alpha secretion on the phorbol 12-myristate 13-acetate and A23187-stimulated HMC-1. Gadolinium 0-2 interleukin 13 Homo sapiens 122-160