PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32824846-1	2020	Autotaxin (ATX) is a secreted enzyme that produces lysophosphatidate (LPA), which signals through six G-protein coupled receptors, promoting tumor growth, metastasis, and survival from chemotherapy and radiotherapy.	lysophosphatidate	51-68	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	0-9
34415509-0	2021	Lysophosphatidate Promotes Sphingosine 1-Phosphate Metabolism and Signaling: Implications for Breast Cancer and Doxorubicin Resistance.	lysophosphatidate	0-17	ATP binding cassette subfamily B member 1	Homo sapiens	112-134
32451553-1	2020	Extracellular lysophosphatidate (LPA) signalling is regulated by the balance of LPA formation by autotaxin (ATX) versus LPA degradation by lipid phosphate phosphatases (LPP) and by the relative expressions of six G-protein-coupled LPA receptors.	lysophosphatidate	14-31	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	97-106
32451553-1	2020	Extracellular lysophosphatidate (LPA) signalling is regulated by the balance of LPA formation by autotaxin (ATX) versus LPA degradation by lipid phosphate phosphatases (LPP) and by the relative expressions of six G-protein-coupled LPA receptors.	lysophosphatidate	14-31	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	108-111
32824846-1	2020	Autotaxin (ATX) is a secreted enzyme that produces lysophosphatidate (LPA), which signals through six G-protein coupled receptors, promoting tumor growth, metastasis, and survival from chemotherapy and radiotherapy.	lysophosphatidate	51-68	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	11-14
31035435-1	2019	This research aimed to evaluate the expression and clinical implication of autotaxin (ATX)-lysophosphatidate (LPA) signaling-related proteins in breast cancer with adipose stroma.	lysophosphatidate	91-108	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	86-89
32305571-0	2020	Role of the autotaxin-lysophosphatidate axis in the development of resistance to cancer therapy.	lysophosphatidate	22-39	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	12-21
32305571-1	2020	Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to produce lysophosphatidate (LPA), which signals through six G-protein coupled receptors (GPCRs).	lysophosphatidate	88-105	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	0-9
32305571-1	2020	Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to produce lysophosphatidate (LPA), which signals through six G-protein coupled receptors (GPCRs).	lysophosphatidate	88-105	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	11-14
32325715-0	2020	Dexamethasone Attenuates X-Ray-Induced Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle in Breast Tissue and Subsequent Breast Fibrosis.	lysophosphatidate	67-84	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	57-66
31455351-0	2019	Expression of proteins related to autotaxin-lysophosphatidate signaling in thyroid tumors.	lysophosphatidate	44-61	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	34-43
31455351-1	2019	BACKGROUND: We aimed to investigate the expression of proteins related with autotaxin (ATX)-lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors.	lysophosphatidate	92-109	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	76-85
31455351-1	2019	BACKGROUND: We aimed to investigate the expression of proteins related with autotaxin (ATX)-lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors.	lysophosphatidate	92-109	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	87-90
28539367-3	2017	Lysophosphatidate produced by ATX promotes inflammatory cytokine secretion in a vicious inflammatory cycle, which increases tumor growth and metastasis and decreases response to chemotherapy.	lysophosphatidate	0-17	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	30-33
30192654-1	2019	Lysophosphatidate (LPA) signaling through 6 receptors is regulated by the balance of LPA production by autotaxin (ATX) vs. LPA degradation by lipid phosphate phosphatases (LPPs).	lysophosphatidate	0-17	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	103-112
30192654-1	2019	Lysophosphatidate (LPA) signaling through 6 receptors is regulated by the balance of LPA production by autotaxin (ATX) vs. LPA degradation by lipid phosphate phosphatases (LPPs).	lysophosphatidate	0-17	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	114-117
25896349-0	2015	Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.	lysophosphatidate	52-69	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	14-23
26037280-1	2015	Autotaxin is a secreted enzyme that converts extracellular lysophosphatidylcholine to lysophosphatidate (LPA).	lysophosphatidate	86-103	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	0-9
28347252-0	2017	The critical role and potential target of the autotaxin/lysophosphatidate axis in pancreatic cancer.	lysophosphatidate	56-73	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	46-55
28347252-1	2017	Autotaxin, an ecto-lysophospholipase D encoded by the human ENNP2 gene, is expressed in multiple tissues, and participates in numerous critical physiologic and pathologic processes including inflammation, pain, obesity, embryo development, and cancer via the generation of the bioactive lipid lysophosphatidate.	lysophosphatidate	293-310	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	0-9
28347252-3	2017	This review provides an overview of the autotaxin/lysophosphatidate axis and collates current knowledge regarding its specific role in pancreatic cancer.	lysophosphatidate	50-67	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	40-49
28347252-4	2017	With a deeper understanding of the critical role of the autotaxin/lysophosphatidate axis in pancreatic cancer, targeting autotaxin or lysophosphatidate receptor may be a potential and promising strategy for cancer therapy.	lysophosphatidate	66-83	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	121-130
26268898-0	2015	Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation.	lysophosphatidate	6-23	lysophosphatidic acid receptor 1	Homo sapiens	58-62
25896349-1	2015	Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC).	lysophosphatidate	67-84	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	0-9
25896349-1	2015	Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC).	lysophosphatidate	67-84	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	11-14
25210149-1	2014	Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling.	lysophosphatidate	46-63	phospholipid phosphatase 1	Mus musculus	0-29
25398768-0	2015	Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment.	lysophosphatidate	0-17	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
25210149-1	2014	Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling.	lysophosphatidate	46-63	phospholipid phosphatase 1	Mus musculus	31-35
21647386-5	2011	We discovered that autotaxin strongly antagonizes the Taxol-induced killing of breast cancer and melanoma cells by converting the abundant extra-cellular lipid, lysophosphatidylcholine, into lysophosphatidate.	lysophosphatidate	191-208	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	19-28
24560789-1	2014	Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate from lysophosphatidylcholine, the most abundant phospholipid in blood plasma.	lysophosphatidate	71-88	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	0-9
24560789-3	2014	The autotaxin/lysophosphatidate signaling axis is involved in wound healing and tissue remodeling, and it drives many chronic inflammatory conditions from fibrosis to colitis, asthma and cancer.	lysophosphatidate	14-31	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	4-13
24599971-1	2014	Autotaxin is a secreted enzyme that produces most extracellular lysophosphatidate, which stimulates 6 G-protein-coupled receptors.	lysophosphatidate	64-81	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	0-9
24599971-10	2014	We also established that autotaxin inhibition could provide a novel therapeutic approach to blocking the adverse effects of lysophosphatidate in cancer.	lysophosphatidate	124-141	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	25-34
25195735-1	2014	ATX (autotaxin) is a secreted lysophospholipase capable of catalysing the formation of the bioactive lipid mediator LPA (lysophosphatidate) from LPC (lysophosphatidylcholine).	lysophosphatidate	121-138	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	0-3
25195735-1	2014	ATX (autotaxin) is a secreted lysophospholipase capable of catalysing the formation of the bioactive lipid mediator LPA (lysophosphatidate) from LPC (lysophosphatidylcholine).	lysophosphatidate	121-138	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	5-14
22954454-0	2013	Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy.	lysophosphatidate	22-39	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	12-21
22954454-2	2013	This is explained mainly since autotaxin produces the lipid growth factor, lysophosphatidate (LPA), which stimulates cell division, survival and migration.	lysophosphatidate	75-92	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	31-40
20709140-0	2011	Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.	lysophosphatidate	14-31	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	45-54
20709140-2	2011	These effects depend mainly on the rapid formation of lysophosphatidate (LPA) by ATX.	lysophosphatidate	54-71	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	81-84
21647386-12	2011	CONCLUSIONS/SIGNIFICANCE: This work demonstrates a previously unknown consequence of lysophosphatidate action that explains why autotaxin and lysophosphatidate protect against Taxol-induced cell death and promote resistance to the action of this important therapeutic agent.	lysophosphatidate	85-102	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	128-137
19079345-2	2009	ATX converts extracellular lysophosphatidylcholine (LPC) into lysophosphatidate (LPA).	lysophosphatidate	62-79	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	0-3
19204929-3	2009	These actions could depend on the noncatalytic effects of autotaxin on cell adhesion, or the catalytic activity of autotaxin, which converts lysophosphatidylcholine into lysophosphatidate in the extracellular fluid surrounding the tumor.	lysophosphatidate	170-187	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	115-124
19204929-7	2009	Knocking down autotaxin secretion, or inhibiting its catalytic activity, blocked cell migration by preventing lysophosphatidate production and the subsequent activation of LPA(1/3) receptors.	lysophosphatidate	110-127	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	14-23
16467304-7	2006	Additionally, arrested LPP2 cells contained decreased lysophosphatidate concentrations and increased ceramide.	lysophosphatidate	54-71	phospholipid phosphatase 2	Homo sapiens	23-27
17389595-5	2007	Hepatic diacylglycerol and lysophosphatidate were elevated in Ad-GPAT1 rats, suggesting a role for these lipid metabolites in the development of hepatic insulin resistance, and hepatic protein kinase Cepsilon was activated, providing a potential mechanism for insulin resistance.	lysophosphatidate	27-44	glycerol-3-phosphate acyltransferase, mitochondrial	Rattus norvegicus	65-70
17057224-0	2006	Lipid phosphate phosphatase-1 regulates lysophosphatidate-induced fibroblast migration by controlling phospholipase D2-dependent phosphatidate generation.	lysophosphatidate	40-57	phospholipid phosphatase 1	Homo sapiens	0-29
10818444-6	2000	Elevated LPP-1 activity attenuated the ability of lysophosphatidate to stimulate mitogen-activated protein kinase (ERK1 and 2) activities and DNA synthesis.	lysophosphatidate	50-67	phospholipid phosphatase 1	Homo sapiens	9-14
12960431-6	2003	Significantly, lysophosphatidate- or thrombin-induced neurite retraction was blocked not only by the Rho-kinase inhibitor Y27632 but also by antisense oligonucleotides targeting myosin IIA.	lysophosphatidate	15-32	myosin, heavy polypeptide 9, non-muscle	Mus musculus	178-188
12890682-0	2003	Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells.	lysophosphatidate	35-52	phospholipase D2	Homo sapiens	15-31
12890682-0	2003	Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells.	lysophosphatidate	35-52	platelet derived growth factor receptor beta	Homo sapiens	80-124
12890682-1	2003	Lysophosphatidate (LPA) mediates multiple cellular responses via heterotrimeric G protein coupled LPA-1, LPA-2, and LPA-3 receptors.	lysophosphatidate	0-17	lysophosphatidic acid receptor 1	Homo sapiens	98-103
12890682-1	2003	Lysophosphatidate (LPA) mediates multiple cellular responses via heterotrimeric G protein coupled LPA-1, LPA-2, and LPA-3 receptors.	lysophosphatidate	0-17	lysophosphatidic acid receptor 2	Homo sapiens	105-110
12890682-1	2003	Lysophosphatidate (LPA) mediates multiple cellular responses via heterotrimeric G protein coupled LPA-1, LPA-2, and LPA-3 receptors.	lysophosphatidate	0-17	lysophosphatidic acid receptor 3	Homo sapiens	116-121
14610755-0	2003	Lipid phosphate phosphatase-1 and Ca2+ control lysophosphatidate signaling through EDG-2 receptors.	lysophosphatidate	47-64	lysophosphatidic acid receptor 1	Homo sapiens	83-88
11324709-0	2001	Lipid phosphate phosphatase-1 dephosphorylates exogenous lysophosphatidate and thereby attenuates its effects on cell signalling.	lysophosphatidate	57-74	phospholipid phosphatase 1	Homo sapiens	0-29
10849424-0	2000	Lipid phosphate phosphatase-1 and Ca2+ control lysophosphatidate signaling through EDG-2 receptors.	lysophosphatidate	47-64	lysophosphatidic acid receptor 1	Homo sapiens	83-88
10818444-6	2000	Elevated LPP-1 activity attenuated the ability of lysophosphatidate to stimulate mitogen-activated protein kinase (ERK1 and 2) activities and DNA synthesis.	lysophosphatidate	50-67	mitogen-activated protein kinase 3	Homo sapiens	115-125
10818444-7	2000	It is concluded that one function of LPP-1 is to dephosphorylate exogenous lysophosphatidate, thereby attenuating cell signaling through endothelial cell differentiation gene (EDG) receptors.	lysophosphatidate	75-92	phospholipid phosphatase 1	Homo sapiens	37-42
10685032-1	2000	The product of the LPP1 gene in Saccharomyces cerevisiae is a membrane-associated enzyme that catalyzes the Mg(2+)-independent dephosphorylation of phosphatidate (PA), diacylglycerol pyrophosphate (DGPP), and lysophosphatidate (LPA).	lysophosphatidate	209-226	phosphatidate phosphatase LPP1	Saccharomyces cerevisiae S288C	19-23
10620492-1	2000	Lipid phosphate phosphatase-1 (LPP-1) dephosphorylates exogenous lysophosphatidate and thereby regulates the activation of lysophosphatidate receptors and cell division.	lysophosphatidate	65-82	phospholipid phosphatase 1	Mus musculus	0-29
10620492-1	2000	Lipid phosphate phosphatase-1 (LPP-1) dephosphorylates exogenous lysophosphatidate and thereby regulates the activation of lysophosphatidate receptors and cell division.	lysophosphatidate	65-82	phospholipid phosphatase 1	Mus musculus	31-36
9468526-15	1998	Since PAP-2 plays a pivotal role in the control of signal transduction by lipid mediators such as phosphatidate, lysophosphatidate, and ceramide-1-phosphate, the ability of androgens to stimulate the expression and activity of this enzyme in prostatic cells may provide an important opportunity for cross-talk between signaling pathways involving lipid mediators and androgens.	lysophosphatidate	113-130	phospholipid phosphatase 1	Homo sapiens	6-11
10359651-6	1999	Rat2 fibroblasts expressing mouse LPP-1 cDNA showed 1.6-2.3-fold increases in the hydrolysis of exogenous lysophosphatidate, phosphatidate and ceramide 1-phosphate compared with vector control cells.	lysophosphatidate	106-123	phospholipid phosphatase 1	Mus musculus	34-39
10359651-11	1999	LPP-1 expression decreased the activation of mitogen-activated protein kinase and DNA synthesis by exogenous lysophosphatidate.	lysophosphatidate	109-126	phospholipid phosphatase 1	Mus musculus	0-5
10359651-12	1999	The product of LPP-1 cDNA is concluded to act partly to degrade exogenous lysophosphatidate and thereby regulate its effects on cell signalling.	lysophosphatidate	74-91	phospholipid phosphatase 1	Mus musculus	15-20
9305923-6	1997	Although the two PAPs hydrolyzed lysophosphatidate and ceramide-1-phosphate in addition to phosphatidate, the hydrolysis of sphingosine-1-phosphate was detected only for PAP-2b.	lysophosphatidate	33-50	PAPS synthetase	Drosophila melanogaster	17-21