PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9074802-9	1997	The products and kinetics observed with MN were consistent with oxidation of MN by either the enzymatic iodinating species formed by reaction of TPO compound I with iodide or phenoxyl radicals/cations generated by TPO-mediated oxidation of a phenolic cosubstrate.	Iodides	165-171	thyroid peroxidase	Homo sapiens	145-148
8943171-8	1997	The thyroglobulin levels fell significantly over the 52-week follow-up period in the iodide group.	Iodides	85-91	thyroglobulin	Homo sapiens	4-17
9001192-10	1996	TSH-R RNA levels were higher, 3.6-fold, in thyroids of a subgroup of Graves" patients that had not been pretreated with iodide before surgery (n = 10) by comparison to thyroids from those that had been treated before surgery, 1.7-fold (n = 25).	Iodides	120-126	thyroid stimulating hormone receptor	Homo sapiens	0-5
9064374-2	1996	Sonographically determined parameters of the thyroid size are correlated to other anthropometrous data and the urinary iodide excretion is correlated to glucosuria, the HbA1c value and the diabetes duration.	Iodides	119-125	hemoglobin subunit alpha 1	Homo sapiens	169-173
8944675-0	1996	Prolactin stimulation of iodide uptake into mouse mammary gland explants.	Iodides	25-31	prolactin	Mus musculus	0-9
8917596-3	1996	By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence.	Iodides	202-208	chloride channel, voltage-sensitive 1 S homeolog	Xenopus laevis	16-21
8917596-3	1996	By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence.	Iodides	202-208	chloride voltage-gated channel 2 S homeolog	Xenopus laevis	26-31
8917596-3	1996	By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence.	Iodides	202-208	chloride channel, voltage-sensitive 1 S homeolog	Xenopus laevis	87-92
8917596-3	1996	By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence.	Iodides	202-208	chloride voltage-gated channel 2 S homeolog	Xenopus laevis	93-98
8855796-10	1996	We suggest that the PA generation induced by PLD stimulation could contribute to the stimulated H2O2 formation and iodide organification observed with the agonists inducing PtdBut accumulation.	Iodides	115-121	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	45-48
8855796-11	1996	Indeed, Bu2cAMP and forskolin, known to decrease iodide organification in human thyroid, inhibited the PLD stimulation induced by ATP and PDBu.	Iodides	49-55	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	103-106
8905632-0	1996	EDTA inhibits lactoperoxidase-catalyzed iodide oxidation by acting as an electron-donor and interacting near the iodide binding site.	Iodides	40-46	lactoperoxidase	Homo sapiens	14-29
8905632-0	1996	EDTA inhibits lactoperoxidase-catalyzed iodide oxidation by acting as an electron-donor and interacting near the iodide binding site.	Iodides	113-119	lactoperoxidase	Homo sapiens	14-29
8905632-1	1996	Ethylenediamine tetraacetate (EDTA) inhibits lactoperoxidase (LPO)-catalyzed rate of iodide oxidation in concentration and pH-dependent manner.	Iodides	85-91	lactoperoxidase	Homo sapiens	45-60
8905632-1	1996	Ethylenediamine tetraacetate (EDTA) inhibits lactoperoxidase (LPO)-catalyzed rate of iodide oxidation in concentration and pH-dependent manner.	Iodides	85-91	lactoperoxidase	Homo sapiens	62-65
8905632-8	1996	The KD of LPO-EDTA complex is significantly increased (62 +/- 5 mM) by iodide suggesting that EDTA binds close to the iodide binding site.	Iodides	71-77	lactoperoxidase	Homo sapiens	10-13
8905632-8	1996	The KD of LPO-EDTA complex is significantly increased (62 +/- 5 mM) by iodide suggesting that EDTA binds close to the iodide binding site.	Iodides	118-124	lactoperoxidase	Homo sapiens	10-13
8768874-4	1996	High concentrations of TSH ( > 1U/L), epidermal growth factor, protein kinase C activation with phorbol esters, and transforming growth factor beta 1 all were strongly inhibitory to iodide metabolism and thyroid hormone synthesis.	Iodides	185-191	transforming growth factor beta 1	Homo sapiens	119-152
8806637-2	1996	We report here the nucleotide and amino acid sequence of the human sodium iodide symporter (hNIS), which mediates the iodide uptake activity in the thyroid gland.	Iodides	74-80	solute carrier family 5 member 5	Homo sapiens	92-96
8806637-4	1996	Transient expression of the hNIS cDNA conferred perchlorate-sensitive iodide uptake to a nonthyroid cell line, COS-7.	Iodides	70-76	solute carrier family 5 member 5	Homo sapiens	28-32
8806637-5	1996	The expression of hNIS was detected at variable levels in papillary thyroid carcinoma tissues but not in any of the thyroid carcinoma cell lines that have lost the iodide uptake activity.	Iodides	164-170	solute carrier family 5 member 5	Homo sapiens	18-22
8806767-5	1996	Our data demonstrate that fluorescence quenching of the proMMP-2/TIMP-2 complex by either acrylamide or iodide is significantly increased following mercurial activation.	Iodides	104-110	TIMP metallopeptidase inhibitor 2	Homo sapiens	65-71
8882155-0	1996	Acute inhibitory effect of excess iodide on ornithine decarboxylase in the thyroid of propylthiouracil-treated rats.	Iodides	34-40	ornithine decarboxylase 1	Rattus norvegicus	44-67
8882155-8	1996	The amount of immunoreactive ODC protein was reduced by iodide treatment (40%).	Iodides	56-62	ornithine decarboxylase 1	Rattus norvegicus	29-32
8882155-11	1996	These results suggest that excess iodide reduces ODC activity in the rat thyroid gland by a post-transcriptional mechanism.	Iodides	34-40	ornithine decarboxylase 1	Rattus norvegicus	49-52
8765983-15	1996	The transepithelial transport of iodide and bulk electrolytes is altered by IGF-I without affecting the epithelial barrier function.	Iodides	33-39	insulin like growth factor 1	Sus scrofa	76-81
8875754-0	1996	Effects of iodide on thyroglobulin biosynthesis in FRTL-5 cells.	Iodides	11-17	thyroglobulin	Rattus norvegicus	21-34
8875754-10	1996	The present results show an inhibitory effect of excess iodide on TSH-stimulated thyroglobulin biosynthesis in FRTL-5 cells.	Iodides	56-62	thyroglobulin	Rattus norvegicus	81-94
8765983-16	1996	Specifically, IGF-I up-regulates the activity of the basolateral iodide pump and increases the iodide permeability of the apical plasma membrane.	Iodides	65-71	insulin like growth factor 1	Sus scrofa	14-19
8765983-16	1996	Specifically, IGF-I up-regulates the activity of the basolateral iodide pump and increases the iodide permeability of the apical plasma membrane.	Iodides	95-101	insulin like growth factor 1	Sus scrofa	14-19
8765983-17	1996	The action of IGF-I on iodide transport is independent of, although synergistic with, that of TSH.	Iodides	23-29	insulin like growth factor 1	Sus scrofa	14-19
8765983-9	1996	Stimulation of iodide transport by IGF-I was modest after 2 days and pronounced after 6 days.	Iodides	15-21	insulin like growth factor 1	Sus scrofa	35-40
8559252-2	1996	The transport of iodide, the first step in thyroid hormogenesis, is catalysed by the Na+/I- symporter, an intrinsic membrane protein that is crucial for the evaluation, diagnosis and treatment of thyroid disorders.	Iodides	17-23	solute carrier family 5 member 5	Rattus norvegicus	85-101
8651700-14	1996	In separate experiments it was shown that the spontaneous conversion of the porphyrin pi-cation radical form of TPO or LPO compound I to the protein radical form was markedly inhibited by a low concentration of iodide, especially in the presence of an iodide acceptor.	Iodides	211-217	thyroid peroxidase	Homo sapiens	112-115
8651700-14	1996	In separate experiments it was shown that the spontaneous conversion of the porphyrin pi-cation radical form of TPO or LPO compound I to the protein radical form was markedly inhibited by a low concentration of iodide, especially in the presence of an iodide acceptor.	Iodides	211-217	lactoperoxidase	Homo sapiens	119-122
8651700-14	1996	In separate experiments it was shown that the spontaneous conversion of the porphyrin pi-cation radical form of TPO or LPO compound I to the protein radical form was markedly inhibited by a low concentration of iodide, especially in the presence of an iodide acceptor.	Iodides	252-258	thyroid peroxidase	Homo sapiens	112-115
8651700-14	1996	In separate experiments it was shown that the spontaneous conversion of the porphyrin pi-cation radical form of TPO or LPO compound I to the protein radical form was markedly inhibited by a low concentration of iodide, especially in the presence of an iodide acceptor.	Iodides	252-258	lactoperoxidase	Homo sapiens	119-122
8983345-7	1996	The 19-40-fold lower activity concentrations of [Nle4,D-Phe7,Lys11-(125I)IBA]-alpha-MSH in tissues accumulating free iodide (thyroid and stomach) suggest a greater inertness of this peptide to deiodination.	Iodides	117-123	pro-opiomelanocortin-alpha	Mus musculus	78-87
8825615-7	1996	When the EPO concentration is suboptimal, virucidal activity is increased by bromide, iodide, and, in this instance, thiocyanate and the virucidal activity of the bromide-supplemented system is inhibited by azide and catalase.	Iodides	86-92	eosinophil peroxidase	Homo sapiens	9-12
8745146-0	1995	Iodide-dependent regulation of thyroid follicular cell proliferation: a mediating role of autocrine insulin-like growth factor-I.	Iodides	0-6	insulin like growth factor 1	Homo sapiens	100-128
8550781-5	1996	Then, guaiacol and iodide oxidation activities of thyroid peroxidase (TPO) in our patient"s thyroid tissue were lower than those of normal controls (guaiacol assay: 1.92 vs. 30.0 +/- 5.7 mGU/mg protein; iodide assay: 1.1 vs. 6.6 +/- 2.8 mIU/mg protein).	Iodides	19-25	thyroid peroxidase	Homo sapiens	50-68
8550781-5	1996	Then, guaiacol and iodide oxidation activities of thyroid peroxidase (TPO) in our patient"s thyroid tissue were lower than those of normal controls (guaiacol assay: 1.92 vs. 30.0 +/- 5.7 mGU/mg protein; iodide assay: 1.1 vs. 6.6 +/- 2.8 mIU/mg protein).	Iodides	19-25	thyroid peroxidase	Homo sapiens	70-73
8550781-5	1996	Then, guaiacol and iodide oxidation activities of thyroid peroxidase (TPO) in our patient"s thyroid tissue were lower than those of normal controls (guaiacol assay: 1.92 vs. 30.0 +/- 5.7 mGU/mg protein; iodide assay: 1.1 vs. 6.6 +/- 2.8 mIU/mg protein).	Iodides	203-209	thyroid peroxidase	Homo sapiens	50-68
8550781-5	1996	Then, guaiacol and iodide oxidation activities of thyroid peroxidase (TPO) in our patient"s thyroid tissue were lower than those of normal controls (guaiacol assay: 1.92 vs. 30.0 +/- 5.7 mGU/mg protein; iodide assay: 1.1 vs. 6.6 +/- 2.8 mIU/mg protein).	Iodides	203-209	thyroid peroxidase	Homo sapiens	70-73
8550781-6	1996	Lineweaver-Burk plot analysis of the oxidation rates of guaiacol and iodide indicated that this patient"s TPO had a defect in the binding of guaiacol and iodide, but the coupling activity of the patient"s TPO was not decreased compared with those of two normal thyroids.	Iodides	69-75	thyroid peroxidase	Homo sapiens	106-109
8550781-6	1996	Lineweaver-Burk plot analysis of the oxidation rates of guaiacol and iodide indicated that this patient"s TPO had a defect in the binding of guaiacol and iodide, but the coupling activity of the patient"s TPO was not decreased compared with those of two normal thyroids.	Iodides	154-160	thyroid peroxidase	Homo sapiens	106-109
8981006-4	1996	Iodide treatment causes a 2-fold decrease in TSH-R expression in association with significant decreases in major histocompatibility complex (MHC) class I and class II gene expression.	Iodides	0-6	thyroid stimulating hormone receptor	Homo sapiens	45-50
8745146-1	1995	An inhibitory action of intracellular iodide on the autocrine production of insulin-like growth factor-I (IGF-I) by thyroid follicular cells (TFCs) in vitro has been investigated as a possible mechanism underlying the iodide-dependent control of TFC proliferation.	Iodides	38-44	insulin like growth factor 1	Homo sapiens	76-104
8745146-1	1995	An inhibitory action of intracellular iodide on the autocrine production of insulin-like growth factor-I (IGF-I) by thyroid follicular cells (TFCs) in vitro has been investigated as a possible mechanism underlying the iodide-dependent control of TFC proliferation.	Iodides	38-44	insulin like growth factor 1	Homo sapiens	106-111
8745146-1	1995	An inhibitory action of intracellular iodide on the autocrine production of insulin-like growth factor-I (IGF-I) by thyroid follicular cells (TFCs) in vitro has been investigated as a possible mechanism underlying the iodide-dependent control of TFC proliferation.	Iodides	218-224	insulin like growth factor 1	Homo sapiens	106-111
8745146-8	1995	While providing evidence, therefore, for a direct relationship between iodide exposure, suppression of autocrine IGF-I production and a regulation of TFC proliferation, the present studies also suggest that suppression of TFC proliferation by iodide may be partially mediated by MMI-insensitive events.	Iodides	71-77	insulin like growth factor 1	Homo sapiens	113-118
7653523-0	1995	NIP- and NAP-taurine bind to external modifier site of AE1 (band 3), at which iodide inhibits anion exchange.	Iodides	78-84	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	55-58
7653523-1	1995	External iodide (I-o) inhibits AE1 (band 3)-mediated anion exchange in human red blood cells by binding to a noncompetitive inhibitory site, the external halide modifier site.	Iodides	9-15	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	31-34
7653523-1	1995	External iodide (I-o) inhibits AE1 (band 3)-mediated anion exchange in human red blood cells by binding to a noncompetitive inhibitory site, the external halide modifier site.	Iodides	17-20	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	31-34
7636435-0	1995	Epidermal growth factor stimulates cell proliferation and inhibits iodide uptake of FRTL-5 cells in vitro.	Iodides	67-73	epidermal growth factor like 1	Rattus norvegicus	0-23
8590598-2	1995	The iodide and acrylamide quenching data show that in CRP one tryptophan residue, Trp-85, is buried within the protein matrix and the other, Trp-13, is moderately exposed on the surface of the protein.	Iodides	4-10	catabolite gene activator protein	Escherichia coli	54-57
8590598-7	1995	In the CRP-cAMP complex the Trp-85, previously buried in the apoprotein becomes totally exposed to the iodide and acrylamide quenchers.	Iodides	103-109	catabolite gene activator protein	Escherichia coli	7-10
7788015-0	1995	delta-Iodolactones decrease epidermal growth factor-induced proliferation and inositol-1,4,5-trisphosphate generation in porcine thyroid follicles--a possible mechanism of growth inhibition by iodide.	Iodides	193-199	epidermal growth factor	Homo sapiens	28-51
7636435-8	1995	In two wild type FRTL-5 cell lines EGF stimulates growth, an effect that is enhanced by the presence of TSH, and partially inhibits iodide uptake.	Iodides	132-138	epidermal growth factor like 1	Rattus norvegicus	35-38
7756348-7	1995	In the case of the iodine-mediated iodide transport, G0, tau and alpha were only mediate voltage-dependent, which means the voltage dependent translocation of the complex encounters a trapezoidal barrier shape.	Iodides	35-41	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	53-70
7749503-8	1995	The IGF-I mRNA expression is under negative control of iodide.	Iodides	55-61	insulin like growth factor 1	Homo sapiens	4-9
7858746-8	1995	Moreover, iodide uptake stimulated by either forskolin or 8-bromo-cAMP also was inhibited by TGF-alpha.	Iodides	10-16	transforming growth factor alpha	Homo sapiens	93-102
7794796-8	1995	TGF beta is known to reduce iodide uptake in thyroid cells; in both FRTL-5H2 and FRTL-R cells, TGF beta was found to inhibit the thyrotropin-induced iodide uptake.	Iodides	28-34	transforming growth factor, beta 1	Rattus norvegicus	0-8
7794796-8	1995	TGF beta is known to reduce iodide uptake in thyroid cells; in both FRTL-5H2 and FRTL-R cells, TGF beta was found to inhibit the thyrotropin-induced iodide uptake.	Iodides	28-34	transforming growth factor, beta 1	Rattus norvegicus	95-103
7794796-8	1995	TGF beta is known to reduce iodide uptake in thyroid cells; in both FRTL-5H2 and FRTL-R cells, TGF beta was found to inhibit the thyrotropin-induced iodide uptake.	Iodides	149-155	transforming growth factor, beta 1	Rattus norvegicus	0-8
7794796-8	1995	TGF beta is known to reduce iodide uptake in thyroid cells; in both FRTL-5H2 and FRTL-R cells, TGF beta was found to inhibit the thyrotropin-induced iodide uptake.	Iodides	149-155	transforming growth factor, beta 1	Rattus norvegicus	95-103
7794796-9	1995	Thus, thyroid cell clones, resistant to the growth-inhibitory activity of TGF beta, were sensitive to TGF beta inhibition of iodide incorporation, suggesting that TGF beta activates divergent signaling pathways in these cells, separately controlling cell proliferation and differentiation parameters.	Iodides	125-131	transforming growth factor, beta 1	Rattus norvegicus	102-110
7794796-9	1995	Thus, thyroid cell clones, resistant to the growth-inhibitory activity of TGF beta, were sensitive to TGF beta inhibition of iodide incorporation, suggesting that TGF beta activates divergent signaling pathways in these cells, separately controlling cell proliferation and differentiation parameters.	Iodides	125-131	transforming growth factor, beta 1	Rattus norvegicus	102-110
7858746-5	1995	When thyroid cells were cultured for 3 days with thyrotropin (TSH) in the presence of TGF-alpha, TSH-induced iodide uptake was inhibited in a dose-dependent manner.	Iodides	109-115	transforming growth factor alpha	Homo sapiens	86-95
7819206-1	1995	The ferric form of soybean lipoxygenase catalyzes an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce iodide ions and 9,11-octadecadienoic acid (9, 11-ODA).	Iodides	130-136	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7695146-5	1995	Activity of TPO was determined, using an iodide oxidation assay and a guaiacol assay.	Iodides	41-47	thyroid peroxidase	Canis lupus familiaris	12-15
7891027-0	1995	Porcine thyroid follicular cells in monolayer culture activate the iodide-responsive precursor form of transforming growth factor-beta 1.	Iodides	67-73	transforming growth factor beta 1	Homo sapiens	103-136
7850004-0	1995	Augmentation of thyrotropin-induced iodide uptake in FRTL-5 cells by immunoglobulins containing blocking thyrotropin-receptor antibodies under NaCl-depleted conditions.	Iodides	36-42	thyroid stimulating hormone receptor	Rattus norvegicus	105-125
7550241-2	1995	Defects in the TPO gene are reported to be the cause of congenital hypothyroidism due to a Total Iodide Organification Defect (TIOD).	Iodides	97-103	thyroid peroxidase	Homo sapiens	15-18
7891027-3	1995	Medium conditioned by iodide (10 mumol/l)-treated follicular cells contained higher levels of both active and total TGF-beta 1 than were present in medium conditioned by untreated cells.	Iodides	22-28	transforming growth factor beta 1	Homo sapiens	116-126
7891027-4	1995	Exposure of cells to iodide also led to a marked decrease in [methyl-3H]thymidine incorporation that was relieved by immunoadsorption with a neutralizing antiserum against the active form of TGF-beta 1.	Iodides	21-27	transforming growth factor beta 1	Homo sapiens	191-201
7891027-7	1995	The study therefore provides direct evidence for a stimulatory role of thyroidal iodide in enhancing the release of latent TGF-beta 1 peptide, and suggests that in normal thyroid follicular cells, as in other TGF-beta 1 producing epithelia, post-secretory processing to the biologically active molecule occurs through an endogenous cellular mechanism.	Iodides	81-87	transforming growth factor beta 1	Homo sapiens	123-133
7925105-1	1994	The effect of epidermal growth factor (EGF) on vectorial iodide (I-) transport was studied in an in vitro model of the polarized porcine thyroid follicular epithelium in Transwell culture chambers.	Iodides	57-63	epidermal growth factor	Homo sapiens	39-42
7798223-1	1994	1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) attenuates the stimulatory effects of cAMP on proliferation and iodide uptake in rat thyroid FRTL-5 cells.	Iodides	103-109	cathelicidin antimicrobial peptide	Rattus norvegicus	77-81
7798223-6	1994	Iodide uptake was synergistically stimulated with both PKAI- and PKAII-directed pairs of cAMP analogs.	Iodides	0-6	cathelicidin antimicrobial peptide	Rattus norvegicus	89-93
7980604-2	1994	These follicles exhibit on their basolateral membrane domain the Na+/I- symporter which allows iodide to accumulate in the thyrocytes.	Iodides	95-101	solute carrier family 5 member 5	Homo sapiens	65-81
7980604-3	1994	The initial rate of iodide influx through the Na+/I- symporter is inhibited up to 98% by the chloride channel blockers.	Iodides	20-26	solute carrier family 5 member 5	Homo sapiens	46-62
7833664-8	1994	It has been suggested that thyroperoxidase (TPO) in patients with Pendred"s syndrome might be defective for coupling but could be partially effective for iodide organification.	Iodides	154-160	thyroid peroxidase	Homo sapiens	27-42
7964323-0	1994	Expression of the endothelin-1 gene in the rat thyroid gland and changes in its peptide and mRNA levels in goiter formation and iodide-induced involution.	Iodides	128-134	endothelin 1	Rattus norvegicus	18-30
7964323-10	1994	During iodide-induced involution, the glandular ET-1 mRNA level remained elevated.	Iodides	7-13	endothelin 1	Rattus norvegicus	48-52
7964323-13	1994	These data demonstrate that the ET-1 gene is expressed in the rat thyroid gland and that the ET-1 mRNA and peptide levels are increased during thyroid hyperplasia and remain elevated during a phase of rapid iodide-induced involution.	Iodides	207-213	endothelin 1	Rattus norvegicus	93-97
7833664-8	1994	It has been suggested that thyroperoxidase (TPO) in patients with Pendred"s syndrome might be defective for coupling but could be partially effective for iodide organification.	Iodides	154-160	thyroid peroxidase	Homo sapiens	44-47
15299369-0	1994	Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes.	Iodides	96-102	carbonic anhydrase 1	Homo sapiens	43-63
8086501-8	1994	The number of active binding sites on hybrid CTB was determined from: (i) titration with the oligosaccharide moiety of GM1 (oligo-GM1) and monitoring the reversal of the Trp fluorescence quenching by iodide ions and (ii) rapid gel filtration over a superdex HR column of a mixture of hybrid CTB and an excess of 3H-labeled oligo-GM1.	Iodides	200-206	phosphate cytidylyltransferase 1B, choline	Homo sapiens	45-48
8074212-0	1994	P2-purinergic stimulation of iodide efflux in FRTL-5 rat thyroid cells involves parallel activation of PLC and PLA2.	Iodides	29-35	phospholipase A2 group IB	Rattus norvegicus	111-115
7835824-0	1994	Interleukin-1 beta (IL-1 beta) binds to intact porcine thyroid follicles, decreases iodide uptake but has no effect on cAMP formation or proliferation.	Iodides	84-90	interleukin 1 beta	Homo sapiens	0-18
7835824-0	1994	Interleukin-1 beta (IL-1 beta) binds to intact porcine thyroid follicles, decreases iodide uptake but has no effect on cAMP formation or proliferation.	Iodides	84-90	interleukin 1 beta	Homo sapiens	20-29
7835824-2	1994	Since the results of different in vitro-studies on the effect of IL-1 on thyrocytes are controversial, our aim was to investigate the existence of specific binding sites for IL-1 beta and its influence on specific functions and growth of isolated porcine thyroid follicles ex vivo with a preserved iodide metabolism.	Iodides	298-304	interleukin 1 beta	Homo sapiens	174-183
7835824-4	1994	IL-1 beta (10 U/ml) decreased basal and TSH-stimulated iodide uptake and organification after an incubation time of 45 min to 6 h without any influence on cAMP-formation.	Iodides	55-61	interleukin 1 beta	Homo sapiens	0-9
7964297-9	1994	Although ET-1 did not affect DNA synthesis stimulated by either EGF or IGF-I, it dose-dependently inhibited TSH-induced iodide uptake and also inhibited iodide uptake stimulated by forskolin and 8-bromo-cAMP.	Iodides	120-126	endothelin 1	Homo sapiens	9-13
7964297-9	1994	Although ET-1 did not affect DNA synthesis stimulated by either EGF or IGF-I, it dose-dependently inhibited TSH-induced iodide uptake and also inhibited iodide uptake stimulated by forskolin and 8-bromo-cAMP.	Iodides	153-159	endothelin 1	Homo sapiens	9-13
7964297-13	1994	Antibody to ET-1 was found to increase TSH-induced iodide uptake.	Iodides	51-57	endothelin 1	Homo sapiens	12-16
8074212-8	1994	We conclude that ATP-induced iodide efflux involves parallel, not sequential, activation of PLC and PLA2.	Iodides	29-35	phospholipase A2 group IB	Rattus norvegicus	100-104
8027236-0	1994	A 20-basepair duplication in the human thyroid peroxidase gene results in a total iodide organification defect and congenital hypothyroidism.	Iodides	82-88	immunoglobulin kappa variable 1-27	Homo sapiens	0-4
8013345-4	1994	HGF inhibited both TSH- and forskolin-stimulated iodide uptake (a thyroid-specific differentiation marker) in the same way as EGF.	Iodides	49-55	hepatocyte growth factor	Canis lupus familiaris	0-3
8045981-8	1994	The rise from basal to maximal levels achieved after hCG stimulation was 1.3 to 3.6 pmol/well for cAMP formation, 34 to 21,408 cpm/well for iodide uptake, 261 to 20,167 cpm/well for iodide organification, and 40 to 927 fmol/well for T3 secretion.	Iodides	140-146	chorionic gonadotropin subunit beta 5	Homo sapiens	53-56
8045981-8	1994	The rise from basal to maximal levels achieved after hCG stimulation was 1.3 to 3.6 pmol/well for cAMP formation, 34 to 21,408 cpm/well for iodide uptake, 261 to 20,167 cpm/well for iodide organification, and 40 to 927 fmol/well for T3 secretion.	Iodides	182-188	chorionic gonadotropin subunit beta 5	Homo sapiens	53-56
8045981-9	1994	Maximal levels elicited by hCG (200 mg/L) relative to maximal values achieved with bovine TSH were 49%, 56%, and 42% for iodide uptake, organification, and T3 secretion, respectively, and only 5% for cAMP.	Iodides	121-127	chorionic gonadotropin subunit beta 5	Homo sapiens	27-30
8045981-10	1994	Iodide uptake proved to be the most sensitive indicator of the thyrotropic activity of hCG, with increases occurring at a concentration of 10 mg/L.	Iodides	0-6	chorionic gonadotropin subunit beta 5	Homo sapiens	87-90
8027219-4	1994	Activation of the PiP2 cascade by TSH (10 mU/mL), NaF, bradykinin, ionomycin, and 12-O-tetradecanoylphorbol-13-acetate stimulates iodide organification.	Iodides	130-136	kininogen 1	Homo sapiens	55-65
8027236-0	1994	A 20-basepair duplication in the human thyroid peroxidase gene results in a total iodide organification defect and congenital hypothyroidism.	Iodides	82-88	thyroid peroxidase	Homo sapiens	39-57
8184893-7	1994	Similarly, iodide and nitrate stimulated renin release.	Iodides	11-17	renin	Rattus norvegicus	41-46
8195117-7	1994	Assuming all tryptophan residues contribute to the observed fluorescence, iodide quenching showed that 8(+/- 1) out 9 of eIF-4B"s tryptophan residues are on the surface of the eIF-4B protein.	Iodides	74-80	eukaryotic translation initiation factor 4B1	Triticum aestivum	121-127
8195117-7	1994	Assuming all tryptophan residues contribute to the observed fluorescence, iodide quenching showed that 8(+/- 1) out 9 of eIF-4B"s tryptophan residues are on the surface of the eIF-4B protein.	Iodides	74-80	eukaryotic translation initiation factor 4B1	Triticum aestivum	176-182
8199304-5	1994	The apparent Ki for SMZ inhibition of TPO- and LPO-catalyzed iodide ion oxidation was approximately 0.42 and 0.11 mM, respectively.	Iodides	61-67	thyroid peroxidase	Homo sapiens	38-41
8037840-13	1994	The stimulatory effect of iodide on hsp induction may also provide an explanation for the frequent occurrence of thyroid autoimmune diseases after iodine exposure.	Iodides	26-32	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-39
8014600-3	1994	Radioreceptor assay of follicular cell-conditioned medium for TGF-beta 1 content confirmed a similar enhancing effect of iodide.	Iodides	121-127	transforming growth factor beta 1	Homo sapiens	62-72
8014600-5	1994	The low level of endogenous active TGF-beta 1 in medium conditioned by either control or iodide-treated cells was confirmed by immunoadsorption with a precipitating antiserum against active TGF-beta 1, when such cells failed to show a reversal of the iodide-induced decrease in [methyl-3H]thymidine incorporation into trichloroacetic acid-precipitable material.	Iodides	89-95	transforming growth factor beta 1	Homo sapiens	35-45
8014600-5	1994	The low level of endogenous active TGF-beta 1 in medium conditioned by either control or iodide-treated cells was confirmed by immunoadsorption with a precipitating antiserum against active TGF-beta 1, when such cells failed to show a reversal of the iodide-induced decrease in [methyl-3H]thymidine incorporation into trichloroacetic acid-precipitable material.	Iodides	89-95	transforming growth factor beta 1	Homo sapiens	190-200
8199304-5	1994	The apparent Ki for SMZ inhibition of TPO- and LPO-catalyzed iodide ion oxidation was approximately 0.42 and 0.11 mM, respectively.	Iodides	61-67	lactoperoxidase	Homo sapiens	47-50
8218257-5	1993	There was weak quenching of CHIP28 tryptophan fluorescence by the polar compounds iodide and acrylamide, with Stern-Volmer constants of 0.13 and 0.71 M-1, respectively.	Iodides	82-88	aquaporin 1 (Colton blood group)	Homo sapiens	28-34
8117301-1	1994	Using non-quantitative reverse-transcription polymerase chain reaction (RT-PCR), we found that thyroid peroxidase (TPO) is expressed in all differentiated thyroid carcinomas examined, although the ratio of the shorter to longer transcript is decreased in tumors that had lost the iodide concentrating capacity.	Iodides	280-286	thyroid peroxidase	Homo sapiens	95-113
8117301-1	1994	Using non-quantitative reverse-transcription polymerase chain reaction (RT-PCR), we found that thyroid peroxidase (TPO) is expressed in all differentiated thyroid carcinomas examined, although the ratio of the shorter to longer transcript is decreased in tumors that had lost the iodide concentrating capacity.	Iodides	280-286	thyroid peroxidase	Homo sapiens	115-118
7711505-8	1994	The TPO inhibition diminished when iodide was increased in the assay, but was not altered by increasing cofactor (H2O2).	Iodides	35-41	thyroid peroxidase	Homo sapiens	4-7
7711505-9	1994	Our results, so far, suggest that the TPO-inhibitory substance may interact reversibly with a specific iodide site on the enzyme or with the oxidized form of iodide, and/or could bind free iodide, making it unavailable for enzymatic oxidation.	Iodides	103-109	thyroid peroxidase	Homo sapiens	38-41
7711505-9	1994	Our results, so far, suggest that the TPO-inhibitory substance may interact reversibly with a specific iodide site on the enzyme or with the oxidized form of iodide, and/or could bind free iodide, making it unavailable for enzymatic oxidation.	Iodides	158-164	thyroid peroxidase	Homo sapiens	38-41
7711505-9	1994	Our results, so far, suggest that the TPO-inhibitory substance may interact reversibly with a specific iodide site on the enzyme or with the oxidized form of iodide, and/or could bind free iodide, making it unavailable for enzymatic oxidation.	Iodides	158-164	thyroid peroxidase	Homo sapiens	38-41
7948605-9	1994	Iodide treatment of goitrous mice also induced modifications of the lymph nodes draining the thyroid: enlargement of the paracortical T zone, presence of germinal centers in cortical follicles, and increase of the density of IL-2R+ cells.	Iodides	0-6	interleukin 2 receptor, alpha chain	Mus musculus	225-230
8131215-3	1994	Myeloperoxidase-dependent degradation of hyaluronic acid is inhibited by superoxide dismutase, desferrioxamine, iodide ion, bromide ion, mannitol, histidine and various antiinflammatory agents.	Iodides	112-118	myeloperoxidase	Homo sapiens	0-15
8237251-1	1993	The oxidation of iodide, guaiacol and 2,2"-azino-di[3-ethyl-benzthiazoline-(6)-sulphonic acid] and the iodination of tyrosyl residues in bovine serum albumin, catalysed by partly purified thyroid peroxidase, were studied.	Iodides	17-23	thyroid peroxidase	Homo sapiens	188-206
8369653-1	1993	We present a survey of the current state of knowledge about the prevalence of the syndrome involved in defective organification of iodide, and the mechanism of iodination and coupling catalyzed by the thyroid peroxidase (TPO) enzyme.	Iodides	131-137	thyroid peroxidase	Homo sapiens	221-224
7902304-4	1993	TGF beta 1 almost completely abolished the cAMP induced stimulation of iodide uptake and thyroperoxidase synthesis.	Iodides	71-77	transforming growth factor beta 1	Homo sapiens	0-10
8415909-2	1993	The charged quenchers, iodide and cesium, produced only slight quenching of ATPase fluorescence, whereas noncharged acrylamide and notably oxygen produced significant quenching.	Iodides	23-29	dynein axonemal heavy chain 8	Homo sapiens	76-82
8369653-4	1993	The classification of defective organification of iodide is primarily based on the site of the biochemical defect, being quantitative (TPO absent) or qualitative (TPO structure, localization or apoenzyme are defectives).	Iodides	50-56	thyroid peroxidase	Homo sapiens	135-138
8369653-4	1993	The classification of defective organification of iodide is primarily based on the site of the biochemical defect, being quantitative (TPO absent) or qualitative (TPO structure, localization or apoenzyme are defectives).	Iodides	50-56	thyroid peroxidase	Homo sapiens	163-166
8369653-11	1993	The resulting TPO enzyme was inactive for iodide organification and coupling reaction.	Iodides	42-48	thyroid peroxidase	Homo sapiens	14-17
8494786-3	1993	Upon infection with the TRK virus, the PC Clone 3 cells lost only the ability to trap iodide and to express the thyroperoxidase gene.	Iodides	86-92	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	24-27
8489704-5	1993	Fluorescence of tryptophan residues in riboflavin-RBP complex and chemically N-bromosucinimide-modified RBP was quenched by iodide and acrylamide.	Iodides	124-130	retinol binding protein 4	Homo sapiens	50-53
8489704-5	1993	Fluorescence of tryptophan residues in riboflavin-RBP complex and chemically N-bromosucinimide-modified RBP was quenched by iodide and acrylamide.	Iodides	124-130	retinol binding protein 4	Homo sapiens	104-107
8448141-1	1993	The kinetics of iodination of tyrosine by hydrogen peroxide and iodide, catalyzed by both horseradish peroxidase (HRP) and lactoperoxidase (LPO), were studied.	Iodides	64-70	lactoperoxidase	Homo sapiens	140-143
8462478-0	1993	Enhancement of thyrotropin-stimulated iodide organification in porcine thyroid cells after protein kinase-C inhibition.	Iodides	38-44	proline rich transmembrane protein 2	Homo sapiens	91-107
8462478-1	1993	We and others have previously shown that 12-O-tetracanoylphorbol-13-acetate (TPA), a protein kinase-C (PKC) activator, inhibits TSH-stimulated iodide organification in porcine thyroid cells.	Iodides	143-149	proline rich transmembrane protein 2	Homo sapiens	85-101
8462478-1	1993	We and others have previously shown that 12-O-tetracanoylphorbol-13-acetate (TPA), a protein kinase-C (PKC) activator, inhibits TSH-stimulated iodide organification in porcine thyroid cells.	Iodides	143-149	proline rich transmembrane protein 2	Homo sapiens	103-106
8462478-10	1993	In summary, these studies indicate that in porcine thyroid cells, three distinct PKC inhibitors all enhanced TSH-stimulated iodide organification and that staurosporine reversed the effects of TPA on TSH-stimulated iodide organification.	Iodides	124-130	proline rich transmembrane protein 2	Homo sapiens	81-84
8462478-11	1993	These findings are consistent with the concept that PKC acts as an endogenous negative modulator of iodide organification in vitro.	Iodides	100-106	proline rich transmembrane protein 2	Homo sapiens	52-55
1282304-5	1992	Cell-attached and outside-out patches from confluent CFTR+ but not CFTR- cells revealed 6-pS channels having linear current-voltage relations, permselectivity Cl > I (partial block by external iodide), and little or no inhibition by 5-nitro-2-(3-phenylpropylamino)-benzoate.	Iodides	196-202	CF transmembrane conductance regulator	Homo sapiens	53-57
8118227-6	1993	Inhibition of protein kinase A and protein kinase C by H7 or HA inhibited TSH-stimulated iodide transport, but did not block the TNF-alpha action, suggesting that the mechanism of TNF-alpha action on thyroid cells is independent of protein kinase A and C.	Iodides	89-95	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	14-30
8118227-6	1993	Inhibition of protein kinase A and protein kinase C by H7 or HA inhibited TSH-stimulated iodide transport, but did not block the TNF-alpha action, suggesting that the mechanism of TNF-alpha action on thyroid cells is independent of protein kinase A and C.	Iodides	89-95	tumor necrosis factor	Rattus norvegicus	180-189
8426735-4	1993	The E1A transfected cells, PC E1A, partially lost the dependency on TSH for growth and completely lost the ability to trap iodide and synthesize thyroglobulin; however they did not acquire the typical markers of the neoplastic phenotype.	Iodides	123-129	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	4-7
1446629-9	1992	Our culture system makes it possible to demonstrate that this high iodide concentration in the basal medium did not increase apical iodide concentration above 10 microM but decreased apical thyroglobulin concentration.	Iodides	67-73	thyroglobulin	Homo sapiens	190-203
1332847-0	1992	Opposite regulation of deoxyribonucleic acid synthesis and iodide uptake in rat thyroid cells by basic fibroblast growth factor: correlation with opposite regulation of c-fos and thyrotropin receptor gene expression.	Iodides	59-65	fibroblast growth factor 2	Rattus norvegicus	97-127
1332847-4	1992	Despite its enhancement of DNA synthesis, however, bFGF decreases TSH-induced cAMP-mediated iodide uptake.	Iodides	92-98	fibroblast growth factor 2	Rattus norvegicus	51-55
1332847-9	1992	Second, bFGF inhibits cAMP signal expression, as evidenced by its ability to inhibit (Bu)2cAMP-induced iodide uptake in FRTL-5 cells.	Iodides	103-109	fibroblast growth factor 2	Rattus norvegicus	8-12
1332847-11	1992	We suggest, therefore, that bFGF causes opposite effects on DNA synthesis and iodide uptake because of its effect on cytosolic Ca2+ levels and because increases in cytosolic Ca2+ can have opposite effects on gene transcription, particularly in the case of the TSH receptor and c-fos genes.	Iodides	78-84	fibroblast growth factor 2	Rattus norvegicus	28-32
1446629-10	1992	The inhibitory effect of iodide on hormonogenesis cannot be due to a competition with tyrosine residues of thyroglobulin for their binding to thyroperoxidase although it could be related, at least in part, to a decrease in protein synthesis.	Iodides	25-31	thyroid peroxidase	Homo sapiens	142-157
1446629-2	1992	The long-term iodination of thyroglobulin secreted into the apical medium of thyroid cells cultured as monolayers on porous bottom chambers reached 5.87 +/- 1.66 atoms of iodine/mol thyroglobulin after 11 days incubation in the presence of TSH (0.1 mU/ml) and iodide (0.5 microM) in the basal medium.	Iodides	260-266	thyroglobulin	Homo sapiens	28-41
1476606-1	1992	The present studies have demonstrated the production of transforming growth factor-beta 1 (TGF-beta 1) by porcine thyroid follicular cells (TFCs) maintained in vitro as subconfluent monolayers, and have confirmed a stimulatory effect of iodide on thyroidal TGF-beta 1 mRNA and peptide release.	Iodides	237-243	transforming growth factor beta 1	Homo sapiens	91-101
1476606-3	1992	In the presence of the anti-thyroid thionamide drug methimazole (MMI; 1 mmol/l), the action of iodide on TGF-beta 1 mRNA was attenuated, although MMI alone had no effect on the control level of TGF-beta 1 mRNA.	Iodides	95-101	transforming growth factor beta 1	Homo sapiens	105-115
1476606-3	1992	In the presence of the anti-thyroid thionamide drug methimazole (MMI; 1 mmol/l), the action of iodide on TGF-beta 1 mRNA was attenuated, although MMI alone had no effect on the control level of TGF-beta 1 mRNA.	Iodides	95-101	transforming growth factor beta 1	Homo sapiens	194-204
1476606-8	1992	In conclusion, TFCs produce TGF-beta 1 mRNA and TGF-beta 1 peptide, which are both increased by iodide treatment in vitro.	Iodides	96-102	transforming growth factor beta 1	Homo sapiens	28-38
1476606-8	1992	In conclusion, TFCs produce TGF-beta 1 mRNA and TGF-beta 1 peptide, which are both increased by iodide treatment in vitro.	Iodides	96-102	transforming growth factor beta 1	Homo sapiens	48-58
1422230-2	1992	The peroxidase activity of TPO in the mitochondria-microsomes fraction was measured with guaiacol or iodide as the second substrate.	Iodides	101-107	thyroid peroxidase	Homo sapiens	27-30
1401057-2	1992	We investigated an adopted boy with iodide organification defect, who presented with florid hypothyroidism at the age of 4 mo, poorly complied with thyroxine treatment, and developed a compressive goiter necessitating partial resection at the age of 12 yr. Biochemical studies revealed the absence of TPO activity in the resected tissue.	Iodides	36-42	thyroid peroxidase	Homo sapiens	301-304
1431687-5	1992	125I-Labelled IGF-I was not chromatographed immediately before injection, resulting in administration of free iodide along with the iodinated peptide.	Iodides	110-116	insulin-like growth factor 1	Rattus norvegicus	14-19
1333055-8	1992	However, cells expressing KCREB showed an 18-40% reduction in TSH-stimulated thymidine incorporation, a 31% increase in the length of the cell cycle, and a 4-fold reduction in TSH-stimulated iodide uptake in comparison with wild type cells or cells tranfected with wild type CREB.	Iodides	191-197	cAMP responsive element binding protein 1	Rattus norvegicus	27-31
1420439-5	1992	The protein was stoichiometrically thiophosphorylated at Ser-19 by myosin light chain kinase and ATP gamma S. The nucleophilic sulfur of the protein phosphorothioate was coupled at pH 7.9 and 25 degrees C to the fluorescent haloacetate [3H]-5-[[2-[(iodoacetyl)-amino]ethyl]amino]naphthalene-1- sulfonic acid ([3H]IAEDANS) by displacement of the iodide.	Iodides	345-351	myosin heavy chain 14	Homo sapiens	67-73
1284330-1	1992	The autoregulatory effects of iodide on thyroid growth and function are discussed to be mediated by iodinated derivatives of essential fatty acids (EFA), esp.	Iodides	30-36	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	154-157
1520303-2	1992	TGF beta acts on thyroid cells by inhibiting cell proliferation and expression of differentiation markers, such as thyroglobulin production and iodide uptake.	Iodides	144-150	transforming growth factor, beta 1	Rattus norvegicus	0-8
1446262-9	1992	In the culture chamber system, thyroglobulin was weakly iodinated (6 atoms of iodide per mole of thyroglobulin; in vivo up to 40 atoms per mole) but hormonogenesis efficiency was close to this one observed in vivo (40%).	Iodides	78-84	thyroglobulin	Homo sapiens	31-44
1446262-10	1992	Iodide concentrations higher than 0.5 microM daily added to the basal medium inhibited iodination of thyroglobulin and hormonosynthesis.	Iodides	0-6	thyroglobulin	Homo sapiens	101-114
1319679-3	1992	We also examined the effects of intracellular pH (pHi) changes on iodide uptake and efflux.	Iodides	66-72	glucose-6-phosphate isomerase	Rattus norvegicus	50-53
1612026-0	1992	Transforming growth factor-beta blocks protein kinase-A-mediated iodide transport and protein kinase-C-mediated DNA synthesis in FRTL-5 rat thyroid cells.	Iodides	65-71	transforming growth factor beta 1	Homo sapiens	0-31
1612026-0	1992	Transforming growth factor-beta blocks protein kinase-A-mediated iodide transport and protein kinase-C-mediated DNA synthesis in FRTL-5 rat thyroid cells.	Iodides	65-71	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	39-55
1612026-1	1992	Recent studies have shown that transforming growth factor-beta (TGF beta) alters DNA synthesis and iodide metabolism in human, porcine, and rat thyroid cells.	Iodides	99-105	transforming growth factor beta 1	Homo sapiens	31-62
1612026-1	1992	Recent studies have shown that transforming growth factor-beta (TGF beta) alters DNA synthesis and iodide metabolism in human, porcine, and rat thyroid cells.	Iodides	99-105	transforming growth factor beta 1	Homo sapiens	64-72
1612026-4	1992	TGF beta (10 ng/ml) inhibited TSH-induced DNA synthesis and iodide uptake.	Iodides	60-66	transforming growth factor, beta 1	Rattus norvegicus	0-8
1612026-6	1992	The protein kinase-A (PKA) activator 8-bromo-cAMP increased both iodide uptake and DNA synthesis; TGF beta inhibited 8-bromo-cAMP-induced [125I]iodide uptake, but not [3H]thymidine incorporation.	Iodides	65-71	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	4-20
1612026-6	1992	The protein kinase-A (PKA) activator 8-bromo-cAMP increased both iodide uptake and DNA synthesis; TGF beta inhibited 8-bromo-cAMP-induced [125I]iodide uptake, but not [3H]thymidine incorporation.	Iodides	65-71	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	22-25
1612026-6	1992	The protein kinase-A (PKA) activator 8-bromo-cAMP increased both iodide uptake and DNA synthesis; TGF beta inhibited 8-bromo-cAMP-induced [125I]iodide uptake, but not [3H]thymidine incorporation.	Iodides	144-150	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	4-20
1612026-6	1992	The protein kinase-A (PKA) activator 8-bromo-cAMP increased both iodide uptake and DNA synthesis; TGF beta inhibited 8-bromo-cAMP-induced [125I]iodide uptake, but not [3H]thymidine incorporation.	Iodides	144-150	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	22-25
1612026-6	1992	The protein kinase-A (PKA) activator 8-bromo-cAMP increased both iodide uptake and DNA synthesis; TGF beta inhibited 8-bromo-cAMP-induced [125I]iodide uptake, but not [3H]thymidine incorporation.	Iodides	144-150	transforming growth factor, beta 1	Rattus norvegicus	98-106
1612026-10	1992	The results also show that TGF beta selectively inhibits PKA-mediated iodide uptake, but not PKA-mediated DNA synthesis.	Iodides	70-76	transforming growth factor, beta 1	Rattus norvegicus	27-35
1612026-10	1992	The results also show that TGF beta selectively inhibits PKA-mediated iodide uptake, but not PKA-mediated DNA synthesis.	Iodides	70-76	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	57-60
1525582-0	1992	Iodide induces transforming growth factor beta 1 (TGF-beta 1) mRNA in sheep thyroid cells.	Iodides	0-6	transforming growth factor beta-1 proprotein	Ovis aries	15-48
1525582-0	1992	Iodide induces transforming growth factor beta 1 (TGF-beta 1) mRNA in sheep thyroid cells.	Iodides	0-6	transforming growth factor beta-1 proprotein	Ovis aries	50-60
1525582-4	1992	These data indicate that the effects of iodide on thyroid growth and function may be mediated by a process that involves organification of iodide and increases in TGF-beta 1 mRNA levels.	Iodides	40-46	transforming growth factor beta-1 proprotein	Ovis aries	163-173
1316115-6	1992	Lactoperoxidase (LPO) could substitute for MPO in the iodide, but not the chloride system.	Iodides	54-60	lactoperoxidase	Homo sapiens	0-15
1319151-7	1992	Other halide ions are also found to inhibit the potato PPi-PFK: bromide is competitive like chloride, whereas fluoride and iodide have a mixed inhibition towards Fru 2,6-P2.	Iodides	123-129	pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha	Solanum tuberosum	55-62
1316115-6	1992	Lactoperoxidase (LPO) could substitute for MPO in the iodide, but not the chloride system.	Iodides	54-60	lactoperoxidase	Homo sapiens	17-20
1316115-6	1992	Lactoperoxidase (LPO) could substitute for MPO in the iodide, but not the chloride system.	Iodides	54-60	myeloperoxidase	Homo sapiens	43-46
1651666-5	1991	Ionic substitution of Cl with nontransported anions, iodide and gluconate, reduced ET-1-induced changes in Isc.	Iodides	53-59	endothelin 1	Canis lupus familiaris	83-87
1391595-12	1992	The low pH buffers affected unlabelled TPO enzyme activity measured by iodide assay.	Iodides	71-77	thyroid peroxidase	Homo sapiens	39-42
1332155-8	1992	Ionic substitution of Cl- with nontransported anions, iodide and gluconate, inhibited endothelin-1-induced increases in PD and SCC.	Iodides	54-60	endothelin 1	Canis lupus familiaris	86-98
1336615-4	1992	The lactoferrin-induced increase in Isc was not altered by amiloride, indomethacin, or propranolol but was abolished by diphenylamine-2-carboxylate or substitution of Cl with iodide in the medium.	Iodides	175-181	lactotransferrin	Canis lupus familiaris	4-15
1957562-0	1991	Effects of triiodothyronine, triiodothyroacetic acid, iopanoic acid and iodide on the thyrotropin-releasing hormone-induced thyrotropin release from superfused rat pituitary fragments.	Iodides	72-78	thyrotropin releasing hormone	Rattus norvegicus	86-115
1892827-5	1991	Quenching of DR1[NAT] and DR1[REL] using the neutral quencher acrylamide results in a 20% increase in total accessibility of the nine-residue Trp population whereas quenching by iodide yields only a 5% increase.	Iodides	178-184	down-regulator of transcription 1	Homo sapiens	13-16
1892827-5	1991	Quenching of DR1[NAT] and DR1[REL] using the neutral quencher acrylamide results in a 20% increase in total accessibility of the nine-residue Trp population whereas quenching by iodide yields only a 5% increase.	Iodides	178-184	down-regulator of transcription 1	Homo sapiens	26-29
1352342-3	1992	The combination of a Sep-pak C18 cartridge and high performance liquid chromatography (HPLC) for the purification of 125I-labeled insulin in our study revealed that the Sep-pak cartridge can serve as the preliminary step to remove unreacted radioactive iodide, the reactants, and labeled but presumably damaged materials unadsorbed to the cartridge.	Iodides	253-259	insulin	Homo sapiens	130-137
1752338-12	1991	In the present study, it has been demonstrated that BB/W rats appear to have a defect(s) in iodide metabolism possibly due to some abnormalities in TPO and Tg synthesis.	Iodides	92-98	thyroid peroxidase	Rattus norvegicus	148-151
1752338-12	1991	In the present study, it has been demonstrated that BB/W rats appear to have a defect(s) in iodide metabolism possibly due to some abnormalities in TPO and Tg synthesis.	Iodides	92-98	thyroglobulin	Rattus norvegicus	156-158
1928330-3	1991	Using the replica filter assay, we demonstrate that the iodide transport 1) is restricted to thyroid cells, 2) is Na+ dependent and electrogenic, 3) is inhibited by ClO4- and SCN-, and 4) is adenosine 3",5"-cyclic monophosphate dependent.	Iodides	56-62	endogenous retrovirus group W member 3	Homo sapiens	165-186
1954313-8	1991	Excess of iodide (0.2 M KJ) or equimolar concentration of diiodotyrosine protects the Tg molecule from iodine induced inactivation.	Iodides	10-16	thyroglobulin	Homo sapiens	86-88
1880476-3	1991	We also investigated the extent to which inhibitory actions of iodide on IGF-I-dependent proliferation of thyroid follicular cells may be attributable to the production of TGF-beta by follicular cells, as opposed to iodide-mediated autoregulation events.	Iodides	63-69	insulin like growth factor 1	Homo sapiens	73-78
1880476-6	1991	This effect was partially reversed when, following initial exposure to follicular cells, iodide-containing preincubation medium was immunoadsorbed with a neutralizing TGF-beta antiserum, and subsequently re-added to the cells.	Iodides	89-95	transforming growth factor beta 1	Homo sapiens	167-175
1846578-7	1991	The inhibitory actions of insulin, IGF-I, and hydrocortisone on cAMP-induced iodide porter activity contrast with their simultaneous and synergistic stimulation of the transcriptional action of cAMP on DNA and thyroglobulin synthesis under these conditions.	Iodides	77-83	insulin-like growth factor 1	Rattus norvegicus	35-40
1712984-3	1991	The sequence of anion selectivity of cAMP-regulated channels in cells containing either endogenous or recombinant CFTR was bromide greater than chloride greater than iodide greater than fluoride.	Iodides	166-172	CF transmembrane conductance regulator	Homo sapiens	114-118
1847855-6	1991	FRTL BAR had significantly higher levels of intracellular cAMP, [3H]thymidine incorporation, and iodide uptake in the absence of added isoproterenol than FRTL RBAR or wild-type cells.	Iodides	97-103	adrenoceptor beta 2	Homo sapiens	5-8
1846578-0	1991	Insulin and insulin-like growth factor-I inhibit thyrotropin-increased iodide transport in serum-depleted FRTL-5 rat thyroid cells: modulation of adenosine 3",5"-monophosphate signal action.	Iodides	71-77	insulin-like growth factor 1	Rattus norvegicus	12-40
1846578-3	1991	Insulin and IGF-I inhibit the action of a cAMP analog to induce iodide uptake in a manner identical to TSH, but do not inhibit basal or TSH-increased cAMP levels; inhibition, thus, results from regulation of cAMP signal action rather than cAMP signal generation.	Iodides	64-70	insulin-like growth factor 1	Rattus norvegicus	12-17
1846578-5	1991	The inhibitory action of insulin/IGF-I is not additive with hydrocortisone, which, under the same conditions, also inhibits TSH- or cAMP-induced iodide porter activity.	Iodides	145-151	insulin-like growth factor 1	Rattus norvegicus	33-38
1857762-4	1991	In the case of the human serum albumin, which has only one Trp residue, this behaviour may be related to different molecular conformations of the protein, as is also manifest in the iodide quenching experiments.	Iodides	182-188	albumin	Homo sapiens	25-38
1999676-6	1991	TSH increased the amount of thyroglobulin secreted into the apical medium by five- to sixfold, whereas high basal iodide concentrations (greater than 5 mumol/l) inhibited thyroglobulin secretion by TSH-stimulated cells.	Iodides	114-120	thyroglobulin	Homo sapiens	171-184
2211707-4	1990	Fluorescence quenching studies revealed that, unlike apoA-IV-1, binding of apoA-IV-2 to phospholipid vesicles induced strong shielding of the amino-terminal tryptophan against iodide quenching.	Iodides	176-182	apolipoprotein A4	Homo sapiens	75-82
2125602-8	1990	A 2 hr incubation of RTF with iodide induced alterations of the structure of IL; an effect mediated by an organic form of actively trapped iodide.	Iodides	30-36	ATPase H+ transporting V0 subunit a2	Homo sapiens	21-24
2125602-8	1990	A 2 hr incubation of RTF with iodide induced alterations of the structure of IL; an effect mediated by an organic form of actively trapped iodide.	Iodides	139-145	ATPase H+ transporting V0 subunit a2	Homo sapiens	21-24
2390477-8	1990	The iodide salt of 4-ethoxycarbonyl-5-(2-thienyl)-1,2-dithiol-3-thione produced a RPF of 2.6 Methyl 3-cyclohexylamino-2-phenylpropenedithiocarboxylate was equally effective (RPF = 2.6).	Iodides	4-15	ribosome production factor 2 homolog	Mus musculus	174-181
1977382-5	1990	Bicarbonate and iodide blocked the binding of GP 130 to the SITS-affinity resin, showing that GP 130 has an anion-binding site.	Iodides	16-22	alanyl aminopeptidase, membrane	Sus scrofa	46-52
1977382-5	1990	Bicarbonate and iodide blocked the binding of GP 130 to the SITS-affinity resin, showing that GP 130 has an anion-binding site.	Iodides	16-22	alanyl aminopeptidase, membrane	Sus scrofa	94-100
2090100-1	1990	Thyroid peroxidase (TPO), the major enzyme in the thyroid hormone synthesis, multifunctionally catalyzes (1) iodide oxidation, (2) iodination of the precursor protein, and (3) a coupling reaction of iodotyrosyl residues.	Iodides	109-115	thyroid peroxidase	Homo sapiens	0-18
2090100-1	1990	Thyroid peroxidase (TPO), the major enzyme in the thyroid hormone synthesis, multifunctionally catalyzes (1) iodide oxidation, (2) iodination of the precursor protein, and (3) a coupling reaction of iodotyrosyl residues.	Iodides	109-115	thyroid peroxidase	Homo sapiens	20-23
2167218-10	1990	We suggest that insulin/IGF-I stimulation of PGE2 production leads to the high basal thymidine incorporation into DNA in aged cells maintained in TSH-depleted (5H) medium; the reduced stimulation by TSH of cAMP content or iodide uptake may reflect PG inhibition (negative feedback regulation) of cAMP production.	Iodides	222-228	insulin-like growth factor 1	Rattus norvegicus	24-29
2225480-4	1990	Purified hCG stimulated iodide uptake into FRTL-5 cells with 25 x 10(3) IU/l being equivalent in potency to 1 mU/l of thyrotrophin (TSH).	Iodides	24-30	chorionic gonadotropin subunit beta 5	Homo sapiens	9-12
2225480-8	1990	Six men with hCG-secreting testicular tumours were biochemically euthyroid although three of their sera stimulated iodide uptake into FRTL-5 cells.	Iodides	115-121	chorionic gonadotropin subunit beta 5	Homo sapiens	13-16
1972336-6	1990	Freezing in the presence of strong chaotropic anions (perchlorate, iodide and thiocyanate) caused the irreversible inactivation of the mosquito AChE.	Iodides	67-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	144-148
2192371-2	1990	Endothelial cell growth factor, fibroblast growth factor, platelet-derived growth factor, and insulin-like growth factor I stimulated thymidine incorporation in a dose-dependent manner without the parallel increase of [125I]iodide uptake.	Iodides	224-230	insulin-like growth factor 1	Rattus norvegicus	94-122
2171921-7	1990	Inhibition by TPOab of the TPO activity was also demonstrated by both guaiacol and iodide assays, and changes in this inhibitory activity during therapy varied among individuals.	Iodides	83-89	thyroid peroxidase	Homo sapiens	14-17
2335517-5	1990	Fluorescence quenching studies revealed that binding of apo-A-IV to the vesicles was associated with a dramatic decrease in the fractional exposure of tyrosine to iodide, and a decrease in the efficiency of intramolecular tyrosine-tryptophan energy transfer.	Iodides	163-169	apolipoprotein A4	Homo sapiens	56-64
2130946-3	1990	Inhibition of TPX-catalyzed reactions by ETU occurs only in the presence of iodide ion with concomitant oxidative metabolism to imidazoline and bisulfite ion.	Iodides	76-82	thyroid peroxidase	Homo sapiens	14-17
33779310-0	2021	The iodide transport defect-causing Y348D mutation in the Na+/I- symporter (NIS) renders the protein intrinsically inactive and impairs its targeting to the plasma membrane.	Iodides	4-10	solute carrier family 5 member 5	Homo sapiens	58-74
2154520-5	1990	Bromide or iodide caused up to a 7-fold increase in EPO activity and a 1.5-fold increase in MPO activity.	Iodides	11-17	eosinophil peroxidase	Homo sapiens	52-55
2154520-5	1990	Bromide or iodide caused up to a 7-fold increase in EPO activity and a 1.5-fold increase in MPO activity.	Iodides	11-17	myeloperoxidase	Homo sapiens	92-95
2154520-10	1990	Stimulation by bromide or iodide could be used to facilitate detection of EPO and to distinguish between MPO and EPO.	Iodides	26-32	eosinophil peroxidase	Homo sapiens	74-77
2154520-10	1990	Stimulation by bromide or iodide could be used to facilitate detection of EPO and to distinguish between MPO and EPO.	Iodides	26-32	myeloperoxidase	Homo sapiens	105-108
2154520-10	1990	Stimulation by bromide or iodide could be used to facilitate detection of EPO and to distinguish between MPO and EPO.	Iodides	26-32	eosinophil peroxidase	Homo sapiens	113-116
2125573-9	1990	Partially purified hCG stimulated iodide uptake and growth of thyroid cells at concentrations of 50 X 10(3) U/l and above.	Iodides	34-40	chorionic gonadotropin subunit beta 5	Homo sapiens	19-22
34922208-1	2022	BACKGROUND: Sodium/iodide symporter (NIS) acts as a vital role in regulation of iodide uptake in thyroid cancer.	Iodides	19-25	solute carrier family 5 member 5	Homo sapiens	37-40
25594695-1	2015	Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones.	Iodides	32-38	solute carrier family 5 member 5	Rattus norvegicus	0-16
25594695-1	2015	Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones.	Iodides	32-38	solute carrier family 5 member 5	Rattus norvegicus	18-21
1730805-10	1992	Purified hCG stimulated iodide uptake in a concentration-dependent manner.	Iodides	24-30	chorionic gonadotropin subunit beta 5	Homo sapiens	9-12
1730805-11	1992	Stimulation of iodide uptake by TSH was inhibited by the simultaneous presence of low concentrations of hCG while activity was restored with high concentrations.	Iodides	15-21	chorionic gonadotropin subunit beta 5	Homo sapiens	104-107
34922208-1	2022	BACKGROUND: Sodium/iodide symporter (NIS) acts as a vital role in regulation of iodide uptake in thyroid cancer.	Iodides	80-86	solute carrier family 5 member 5	Homo sapiens	37-40
34922208-2	2022	However, the efficient approach to increase NIS expression and the mechanism of NIS-mediated iodide uptake in thyroid cancer remain unclear.	Iodides	93-99	solute carrier family 5 member 5	Homo sapiens	80-83
34922208-9	2022	saRNA-mediated NIS expression inhibited cell proliferation, induced apoptosis and autophagy, and promoted iodide uptake in SW579 cells.	Iodides	106-112	solute carrier family 5 member 5	Homo sapiens	15-18
34922208-11	2022	For mechanism analysis, we found that NIS upregulation exerted the effects on cell proliferation, apoptosis, autophagy, and iodide uptake via regulating AMPK/mTOR pathway.	Iodides	124-130	solute carrier family 5 member 5	Homo sapiens	38-41
34922208-12	2022	We also demonstrated that saRNA-mediated NIS expression promoted iodide uptake in vivo.	Iodides	65-71	solute carrier family 5 member 5	Homo sapiens	41-44
34922208-13	2022	CONCLUSION: saRNA-mediated NIS expression acted as a critical role in increasing iodide uptake via AMPK/mTOR pathway in thyroid cancer.	Iodides	81-87	solute carrier family 5 member 5	Homo sapiens	27-30
34922208-13	2022	CONCLUSION: saRNA-mediated NIS expression acted as a critical role in increasing iodide uptake via AMPK/mTOR pathway in thyroid cancer.	Iodides	81-87	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	99-103
34922208-13	2022	CONCLUSION: saRNA-mediated NIS expression acted as a critical role in increasing iodide uptake via AMPK/mTOR pathway in thyroid cancer.	Iodides	81-87	mechanistic target of rapamycin kinase	Homo sapiens	104-108
34915750-0	2022	Pathogenesis of multinodular goiter in elderly XB130 deficient mice: alteration of thyroperoxidase affinity with iodide and hydrogen peroxide.	Iodides	113-119	thyroid peroxidase	Mus musculus	83-98
34915750-8	2022	The activity of thyroperoxidase (Tpo) was examined by spectrophotometric evaluation of iodide-oxidation.	Iodides	87-93	thyroid peroxidase	Mus musculus	16-31
34915750-8	2022	The activity of thyroperoxidase (Tpo) was examined by spectrophotometric evaluation of iodide-oxidation.	Iodides	87-93	thyroid peroxidase	Mus musculus	33-36
34915750-12	2022	In Xb130+/+ mice, Tpo shows high affinity with H2O2 throughout aging, but reduced affinity with iodide in an age-dependent manner.	Iodides	96-102	thyroid peroxidase	Mus musculus	18-21
34915750-13	2022	By contrast, in elderly Xb130-/- mice, the affinity of Tpo for iodide remained high but the affinity of Tpo for H2O2 was reduced.	Iodides	63-69	thyroid peroxidase	Mus musculus	55-58
34633190-1	2021	We report herein an intermolecular syn-arylalkylation and alkenylalkylation of alkenyl amines with two different organohalides (iodides and bromides) using Ni(II) catalyst.	Iodides	128-135	synemin	Homo sapiens	35-38
34514854-1	2021	BACKGROUND: Iodide transport defect (ITD) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to homozygous or compound heterozygous pathogenic variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient iodide accumulation in thyroid follicular cells, thus impairing thyroid hormonogenesis.	Iodides	12-18	solute carrier family 5 member 5	Homo sapiens	178-184
34514854-1	2021	BACKGROUND: Iodide transport defect (ITD) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to homozygous or compound heterozygous pathogenic variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient iodide accumulation in thyroid follicular cells, thus impairing thyroid hormonogenesis.	Iodides	216-222	solute carrier family 5 member 5	Homo sapiens	178-184
34517596-0	2021	Iodide-modified Ag nanoparticles coupled with DSN-Assisted cycling amplification for label-free and ultrasensitive SERS detection of MicroRNA-21.	Iodides	0-6	microRNA 21	Homo sapiens	133-144
34806438-1	2022	The sodium-iodide symporter (NIS, SLC5A5) is expressed at the basolateral membrane of the thyroid follicular cell, and facilitates the thyroidal iodide uptake required for thyroid hormone biosynthesis.	Iodides	145-151	solute carrier family 5 member 5	Homo sapiens	29-32
34806438-1	2022	The sodium-iodide symporter (NIS, SLC5A5) is expressed at the basolateral membrane of the thyroid follicular cell, and facilitates the thyroidal iodide uptake required for thyroid hormone biosynthesis.	Iodides	145-151	solute carrier family 5 member 5	Homo sapiens	34-40
34761444-2	2022	To perform it"s innate immune action against invading microbes, LPO utilizes hydrogen peroxide (H2 O2 ) to convert thiocyanate (SCN ) and iodide (I ) ions into the oxidizing compounds hypothiocyanite (OSCN ) and hypoiodite (IO ).	Iodides	138-144	lactoperoxidase	Homo sapiens	64-67
34761444-4	2022	We report here the structure of the complex of LPO with IO  as the first structural evidence of the conversion of iodide into hypoiodite by LPO.	Iodides	114-120	lactoperoxidase	Homo sapiens	47-50
34761444-4	2022	We report here the structure of the complex of LPO with IO  as the first structural evidence of the conversion of iodide into hypoiodite by LPO.	Iodides	114-120	lactoperoxidase	Homo sapiens	140-143
34831012-0	2021	MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells.	Iodides	70-76	Rac family small GTPase 1	Homo sapiens	32-36
34831012-8	2021	In a previous work, we have shown that the activity of the small GTPase RAC1 has a positive impact on TSH-induced NIS expression and iodide uptake in thyroid cells.	Iodides	133-139	Rac family small GTPase 1	Homo sapiens	72-76
34739238-1	2021	We report an observation of spin-orbit excited dipole-bound states (DBSs) in arginine-iodide complexes (Arg I-) by using temperature-dependent, wavelength-resolved "iodide-tagging" negative ion photoelectron spectroscopy.	Iodides	165-171	spindlin 1	Homo sapiens	28-32
34771624-8	2021	Through a systematic validation of the detected interactions by co-immunoprecipitation and Western blot, followed by the biochemical and functional characterization of the contribution of each interactor to NIS PM residency and iodide uptake, we were able to identify a pathway by which the PM localization and function of NIS depends on its binding to SRC kinase, which leads to the recruitment and activation of the small GTPase RAC1.	Iodides	228-234	solute carrier family 5 member 5	Homo sapiens	323-326
34771624-8	2021	Through a systematic validation of the detected interactions by co-immunoprecipitation and Western blot, followed by the biochemical and functional characterization of the contribution of each interactor to NIS PM residency and iodide uptake, we were able to identify a pathway by which the PM localization and function of NIS depends on its binding to SRC kinase, which leads to the recruitment and activation of the small GTPase RAC1.	Iodides	228-234	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	353-356
34771624-8	2021	Through a systematic validation of the detected interactions by co-immunoprecipitation and Western blot, followed by the biochemical and functional characterization of the contribution of each interactor to NIS PM residency and iodide uptake, we were able to identify a pathway by which the PM localization and function of NIS depends on its binding to SRC kinase, which leads to the recruitment and activation of the small GTPase RAC1.	Iodides	228-234	Rac family small GTPase 1	Homo sapiens	431-435
34650915-1	2021	Iodide uptake and the metabolism of thyroid cells are regulated by thyrotropin (TSH)-TSH receptor (TSHR) signaling.	Iodides	0-6	thyroid stimulating hormone receptor	Homo sapiens	85-97
34853814-2	2021	Due to its iodide trapping activity, NIS is a powerful theranostic tool for diagnostic imaging and the application of therapeutic radionuclides.	Iodides	11-17	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	37-40
34477762-0	2021	Non-porous interpenetrating Co-bpe MOF for colorimetric iodide sensing.	Iodides	56-62	lysine acetyltransferase 8	Homo sapiens	35-38
34477762-3	2021	We herein report for the first time, hitherto, a non-porous MOF with an interpenetrating ladder structure for iodide sensing.	Iodides	110-116	lysine acetyltransferase 8	Homo sapiens	60-63
34650915-9	2021	PI3K/AKT/mTOR signaling activation enhanced Galpha12/13 signaling through increasing LARG levels but also inhibited the expression of molecules downstream of Galphas signaling, including thyroid-specific molecules, and iodide uptake.	Iodides	219-225	AKT serine/threonine kinase 1	Homo sapiens	5-8
34650915-9	2021	PI3K/AKT/mTOR signaling activation enhanced Galpha12/13 signaling through increasing LARG levels but also inhibited the expression of molecules downstream of Galphas signaling, including thyroid-specific molecules, and iodide uptake.	Iodides	219-225	mechanistic target of rapamycin kinase	Homo sapiens	9-13
34650915-1	2021	Iodide uptake and the metabolism of thyroid cells are regulated by thyrotropin (TSH)-TSH receptor (TSHR) signaling.	Iodides	0-6	thyroid stimulating hormone receptor	Homo sapiens	99-103
34650915-5	2021	Therefore, in this study, we aimed to explore the role of abnormal TSH-TSHR signaling activation in regulating iodide uptake and cell mobility in thyroid cancer and its relationship with PI3K/AKT/mTOR signaling.	Iodides	111-117	thyroid stimulating hormone receptor	Homo sapiens	71-75
34650915-9	2021	PI3K/AKT/mTOR signaling activation enhanced Galpha12/13 signaling through increasing LARG levels but also inhibited the expression of molecules downstream of Galphas signaling, including thyroid-specific molecules, and iodide uptake.	Iodides	219-225	G protein subunit alpha 12	Homo sapiens	44-55
34650915-5	2021	Therefore, in this study, we aimed to explore the role of abnormal TSH-TSHR signaling activation in regulating iodide uptake and cell mobility in thyroid cancer and its relationship with PI3K/AKT/mTOR signaling.	Iodides	111-117	AKT serine/threonine kinase 1	Homo sapiens	192-195
34650915-9	2021	PI3K/AKT/mTOR signaling activation enhanced Galpha12/13 signaling through increasing LARG levels but also inhibited the expression of molecules downstream of Galphas signaling, including thyroid-specific molecules, and iodide uptake.	Iodides	219-225	PAXIP1 associated glutamate rich protein 1	Homo sapiens	158-165
34650915-5	2021	Therefore, in this study, we aimed to explore the role of abnormal TSH-TSHR signaling activation in regulating iodide uptake and cell mobility in thyroid cancer and its relationship with PI3K/AKT/mTOR signaling.	Iodides	111-117	mechanistic target of rapamycin kinase	Homo sapiens	196-200
34500854-5	2021	Here, we present the syntheses, crystal structures, DFT calculations, and antiproliferative activity of iodide analogs of AP-1 and AP-2, i.e., AP-5 and AP-4, respectively.	Iodides	104-110	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-126
34520744-1	2022	The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells.	Iodides	57-63	solute carrier family 5 member 5	Homo sapiens	29-32
34500854-5	2021	Here, we present the syntheses, crystal structures, DFT calculations, and antiproliferative activity of iodide analogs of AP-1 and AP-2, i.e., AP-5 and AP-4, respectively.	Iodides	104-110	transcription factor AP-2 alpha	Homo sapiens	131-135
34500854-5	2021	Here, we present the syntheses, crystal structures, DFT calculations, and antiproliferative activity of iodide analogs of AP-1 and AP-2, i.e., AP-5 and AP-4, respectively.	Iodides	104-110	adaptor related protein complex 5 subunit beta 1	Homo sapiens	143-147
34500854-5	2021	Here, we present the syntheses, crystal structures, DFT calculations, and antiproliferative activity of iodide analogs of AP-1 and AP-2, i.e., AP-5 and AP-4, respectively.	Iodides	104-110	transcription factor AP-4	Homo sapiens	152-156
34638176-5	2021	TPO and TG are the two key proteins necessary for the biosynthesis of thyroid hormones in the presence of iodide and H2O2.	Iodides	106-112	thyroid peroxidase	Homo sapiens	0-3
34387194-1	2021	The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active iodide transport into the thyroid gland and into several extrathyroidal tissues.	Iodides	95-101	solute carrier family 5 member 5	Homo sapiens	29-32
34387194-2	2021	NIS-mediated iodide uptake plays a pivotal role in the biosynthesis of thyroid hormones, of which iodide is an essential constituent.	Iodides	13-19	solute carrier family 5 member 5	Homo sapiens	0-3
34387194-2	2021	NIS-mediated iodide uptake plays a pivotal role in the biosynthesis of thyroid hormones, of which iodide is an essential constituent.	Iodides	98-104	solute carrier family 5 member 5	Homo sapiens	0-3
34387194-6	2021	A review on the hormones, cytokines, and iodide itself that regulate NIS is provided.	Iodides	41-47	solute carrier family 5 member 5	Homo sapiens	69-72
34196428-0	2021	The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane.	Iodides	39-45	scribble planar cell polarity protein	Homo sapiens	16-21
34488281-4	2021	Furthermore, functional studies show that the abnormal expression or dysfunction of iodide transporters might serves as tumor promoters or inhibitors via regulated the mTOR signal pathway, the MAPKs signal pathway, and the NF-kappaB signal pathway, together contributed to the regulation of cell proliferation, invasion, metastasis and apoptosis, in which plays the role of non iodide transported function.	Iodides	84-90	mechanistic target of rapamycin kinase	Homo sapiens	168-172
34488281-4	2021	Furthermore, functional studies show that the abnormal expression or dysfunction of iodide transporters might serves as tumor promoters or inhibitors via regulated the mTOR signal pathway, the MAPKs signal pathway, and the NF-kappaB signal pathway, together contributed to the regulation of cell proliferation, invasion, metastasis and apoptosis, in which plays the role of non iodide transported function.	Iodides	84-90	nuclear factor kappa B subunit 1	Homo sapiens	223-232
34595089-3	2021	The stored iodine within the pores interacts with free iodide ions present in the bulk electrolyte via comproportionation reactions leading to polyiodide (I3 - and I5 -) formations.	Iodides	55-61	brain protein I3	Homo sapiens	155-166
34196428-0	2021	The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane.	Iodides	39-45	solute carrier family 5 member 5	Homo sapiens	57-60
34196428-1	2021	The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the thyroid follicular cell and mediates iodide accumulation required for normal thyroid hormonogenesis.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
34196428-1	2021	The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the thyroid follicular cell and mediates iodide accumulation required for normal thyroid hormonogenesis.	Iodides	123-129	solute carrier family 5 member 5	Homo sapiens	29-32
34196428-5	2021	As a result, R636* NIS is barely targeted to the plasma membrane and therefore iodide transport is reduced.	Iodides	79-85	solute carrier family 5 member 5	Homo sapiens	19-22
35455992-5	2022	Here, we analyzed the role of CREB3L1 as a TSH-dependent transcriptional regulator of the expression of the sodium/iodide symporter (NIS), a major thyroid protein that mediates iodide uptake.	Iodides	177-183	solute carrier family 5 member 5	Rattus norvegicus	108-131
34241390-3	2021	In this work, Bismuth(III) halometallates incorporating chloride, bromide, and iodide have been studied via density functional theory employing B3LYP-D3BJ/aug-cc-pVDZ.	Iodides	79-85	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	146-149
34447537-3	2021	Halogen-atom transfer (XAT) from alpha-aminoalkyl radicals is leveraged to convert the iodide into the corresponding open-shell species, while its following addition to formaldehyde is rendered irreversible by trapping the transient O-radical with PPh3.	Iodides	87-93	caveolin 1	Homo sapiens	248-252
35600585-2	2022	ITD is an autosomal recessive disorder caused by loss-of-function variants in the sodium/iodide symporter (NIS)-coding SLC5A5 gene.	Iodides	89-95	solute carrier family 5 member 5	Homo sapiens	119-125
34060818-2	2021	Using an iodide-modified ruthenium-BINAP-catalyst and O-benzhydryl alkoxyallene 1a, carbonyl (alpha-alkoxy)allylation occurs from the alcohol or aldehyde oxidation level to form enantiomerically enriched syn-sec,tert-diols.	Iodides	9-15	synemin	Homo sapiens	204-207
35566353-8	2022	This model will allow for high-throughput screening of GPCR regulators that mediate increased intracellular calcium signaling using the calcium-activated transport of iodide ions by Ano1.	Iodides	167-173	anoctamin 1	Homo sapiens	182-186
35438852-1	2022	OBJECTIVES: Iodide transport defect (ITD) is one of the principal causes of congenital hypothyroidism (CH) and its primary molecular mechanism is a mutation of the sodium/iodide symporter (NIS) gene.	Iodides	12-18	solute carrier family 5 member 5	Homo sapiens	189-192
35438852-1	2022	OBJECTIVES: Iodide transport defect (ITD) is one of the principal causes of congenital hypothyroidism (CH) and its primary molecular mechanism is a mutation of the sodium/iodide symporter (NIS) gene.	Iodides	171-177	solute carrier family 5 member 5	Homo sapiens	189-192
35455992-7	2022	This, in turn, impacts on NIS-mediated iodide uptake.	Iodides	39-45	solute carrier family 5 member 5	Rattus norvegicus	26-29
35455992-5	2022	Here, we analyzed the role of CREB3L1 as a TSH-dependent transcriptional regulator of the expression of the sodium/iodide symporter (NIS), a major thyroid protein that mediates iodide uptake.	Iodides	177-183	solute carrier family 5 member 5	Rattus norvegicus	133-136
35175311-0	2022	Excess iodide-induced reactive oxygen species elicit iodide efflux via beta-tubulin-associated ClC-3 in thyrocytes.	Iodides	7-13	chloride voltage-gated channel 3	Rattus norvegicus	95-100
35013551-1	2022	The sodium (Na+):multivitamin transporter (SMVT), encoded by SLC5A6, belongs to the sodium:solute symporter family and is required for the Na+-dependent uptake of biotin (vitamin B7), pantothenic acid (vitamin B5), the vitamin-like substance alpha-lipoic acid, and iodide.	Iodides	265-271	solute carrier family 5 member 6	Homo sapiens	43-47
35013551-1	2022	The sodium (Na+):multivitamin transporter (SMVT), encoded by SLC5A6, belongs to the sodium:solute symporter family and is required for the Na+-dependent uptake of biotin (vitamin B7), pantothenic acid (vitamin B5), the vitamin-like substance alpha-lipoic acid, and iodide.	Iodides	265-271	solute carrier family 5 member 6	Homo sapiens	61-67
35175311-0	2022	Excess iodide-induced reactive oxygen species elicit iodide efflux via beta-tubulin-associated ClC-3 in thyrocytes.	Iodides	53-59	chloride voltage-gated channel 3	Rattus norvegicus	95-100
35175311-2	2022	However, the extent of 2Cl-/H+ exchanger (ClC-3) involvement in the iodide (I-) efflux from thyrocytes remains unclear.	Iodides	68-74	chloride voltage-gated channel 3	Rattus norvegicus	42-47
35113089-4	2022	This behaviour is accounted for by a change in the reaction mechanism for Ar-I, which involves two molecules of copper(I) complex, the second one stabilising the incipient iodide formed in the C-I breaking (oxidative addition) and C-I forming (reductive elimination) processes.	Iodides	172-178	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	74-78
2546752-3	1989	Iodide also inhibited the cAMP-dependent growth of FRTL5 cells induced by forskolin and (Bu)2cAMP, as well as the cAMP-independent mitogenesis induced by insulin-like growth factor-I.	Iodides	0-6	insulin-like growth factor 1	Rattus norvegicus	154-182
35227018-9	2022	In the thyroid, CFTR and pendrin might have overlapping functions in driving the apical flux of iodide within the follicular lumen.	Iodides	96-102	CF transmembrane conductance regulator	Homo sapiens	16-20
35227018-9	2022	In the thyroid, CFTR and pendrin might have overlapping functions in driving the apical flux of iodide within the follicular lumen.	Iodides	96-102	solute carrier family 26 member 4	Homo sapiens	25-32
35227018-3	2022	While pendrin drives chloride reabsorption and bicarbonate, thiocyanate or iodide secretion within the apical compartment, CFTR represents a pathway for the apical efflux of chloride, bicarbonate, and possibly iodide.	Iodides	75-81	solute carrier family 26 member 4	Homo sapiens	6-13
35227018-3	2022	While pendrin drives chloride reabsorption and bicarbonate, thiocyanate or iodide secretion within the apical compartment, CFTR represents a pathway for the apical efflux of chloride, bicarbonate, and possibly iodide.	Iodides	210-216	CF transmembrane conductance regulator	Homo sapiens	123-127
2546752-4	1989	The effect of iodide to inhibit both TSH- and insulin-like growth factor-I-stimulated growth in FRTL5 cells was abolished by concomitant culture with methimazole, and no iodide inhibition of growth was observed in L6 myoblasts and BRL 30E hepatocytes.	Iodides	14-20	insulin-like growth factor 1	Rattus norvegicus	46-74
2543498-4	1989	Moreover, in analogy to the effect produced upon other differentiated cells in culture, such as myoblasts and adipocytes, TGF beta 1 modulates the expression of FRTL5-specific thyroid markers, reducing thyroglobulin biosynthesis and the ability to concentrate the iodide.	Iodides	264-270	transforming growth factor, beta 1	Rattus norvegicus	122-132
2542309-9	1989	Since as little as 1 atom of iodide bound per molecule of transferrin was associated with substantial losses in iron binding capacity, there appears to be a high specificity of myeloperoxidase-catalyzed iodination for residues at or near the iron binding sites.	Iodides	29-35	transferrin	Homo sapiens	58-69
2474836-20	1989	Iodide exerted a modest inhibition of photohemolysis and loss of AchE sensitized by E16, but had virtually no influence on sensitization by EYMA.	Iodides	0-6	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-69
2474836-20	1989	Iodide exerted a modest inhibition of photohemolysis and loss of AchE sensitized by E16, but had virtually no influence on sensitization by EYMA.	Iodides	0-6	RNA, U105C small nucleolar	Homo sapiens	84-87
2542309-9	1989	Since as little as 1 atom of iodide bound per molecule of transferrin was associated with substantial losses in iron binding capacity, there appears to be a high specificity of myeloperoxidase-catalyzed iodination for residues at or near the iron binding sites.	Iodides	29-35	myeloperoxidase	Homo sapiens	177-192
2673271-7	1989	Transforming growth factor beta was, however, lower in non-toxic goitre than in Graves" disease and in normal thyroid tissue, but could be increased by exposure of the cells to micromolar concentrations of iodide.	Iodides	206-212	transforming growth factor beta 1	Homo sapiens	0-31
2471981-4	1989	In thyroid cells expressing beta 2 receptors, the beta 2 agonist isoproterenol activates adenylate cyclase, induces the expression of a thyroid-specific iodide carrier system, and can substitute for TSH to promote growth.	Iodides	153-159	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	28-34
2471981-4	1989	In thyroid cells expressing beta 2 receptors, the beta 2 agonist isoproterenol activates adenylate cyclase, induces the expression of a thyroid-specific iodide carrier system, and can substitute for TSH to promote growth.	Iodides	153-159	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	50-56
2495823-0	1989	Regulation of thyroperoxidase, thyroglobulin and iodide levels in sheep thyroid cells by TSH, tumor promoters and epidermal growth factor.	Iodides	49-55	EGF	Ovis aries	114-137
2923379-6	1989	EPO in the presence of the H2O2-producing enzyme glucose oxidase (GO), Cl-, 0.11 M, and iodide caused ciliostasis, bleb formation, and exfoliation of epithelial cells at concentrations as low as 1 U/ml (3.9 micrograms/ml).	Iodides	88-94	eosinophil peroxidase	Cavia porcellus	0-3
2920831-4	1989	Furthermore, a 15% increase in slopes of Stern-Volmer plots for IAF-TM in the presence of DNase I demonstrated a greater susceptibility of the fluorescein group to dynamic quenching by iodide.	Iodides	185-191	deoxyribonuclease-1	Oryctolagus cuniculus	90-97
2495823-6	1989	A time course of TSH stimulation of TPO mRNA showed increases after 8 h of TSH stimulation, whereas induction of Tg mRNA by TSH was seen at 24 h. Iodide trapping and organification were also TSH-dependent processes, showing maximum activities at 300-500 muU/ml of TSH.	Iodides	146-152	thyroid peroxidase	Ovis aries	36-39
2495823-6	1989	A time course of TSH stimulation of TPO mRNA showed increases after 8 h of TSH stimulation, whereas induction of Tg mRNA by TSH was seen at 24 h. Iodide trapping and organification were also TSH-dependent processes, showing maximum activities at 300-500 muU/ml of TSH.	Iodides	146-152	thyroglobulin	Ovis aries	113-115
2663567-9	1989	The results show that in calf thyroid cells, iodide transport and Tg gene expression are regulated by TSH through cyclic AMP; hydrocortisone potentiates this effect on Tg gene expression, while all growth promoting factors inhibit the expression of these differentiated functions.	Iodides	45-51	thyroglobulin	Bos taurus	168-170
2811602-6	1989	In addition, epidermal growth factor (EGF, 10(-9)M) and phorbol 12-myristate 13-acetate (PMA, 10(-8) M) completely inhibited TSH stimulation on both activities and also basal (5H) activity of iodide metabolism.	Iodides	192-198	epidermal growth factor	Homo sapiens	13-36
3036482-0	1987	A growth stimulatory effect of iodide is suggested by its effects on c-myc messenger ribonucleic acid levels, [3H]thymidine incorporation, and mitotic activity of porcine follicle cells in suspension culture.	Iodides	31-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-74
2842993-6	1988	The inhibitory effect of iodide was also seen in growth stimulated by insulin, insulin-like growth factor-I or 12-O-tetradecanoyl phorbol 13-acetate, suggesting multiple sites of action of iodide in the process of growth of FRTL-5 cells.	Iodides	25-31	insulin-like growth factor 1	Rattus norvegicus	79-107
3401009-8	1988	Iodide markedly affected the interconversions between native enzyme, Compound II, and Compound III for lactoperoxidase and thyroid peroxidase.	Iodides	0-6	lactoperoxidase	Homo sapiens	103-118
3401009-9	1988	A low concentration of iodide (4 microM) completely blocked the formation of Compound II when lactoperoxidase or thyroid peroxidase was treated with 6 microM H2O2.	Iodides	23-29	lactoperoxidase	Homo sapiens	94-109
2840260-0	1988	Inhibition by islet-activating protein, pertussis toxin, of P2-purinergic receptor-mediated iodide efflux and phosphoinositide turnover in FRTL-5 cells.	Iodides	92-98	magnesium transporter 1	Rattus norvegicus	14-38
2840263-4	1988	When porcine thyroid cells were cultured with TSH for 3 days in the presence of TGF-beta, TSH-induced iodide uptake and organification were reduced at rates that were dependent on the TGF-beta concentrations.	Iodides	102-108	transforming growth factor beta 1	Homo sapiens	80-88
2840263-4	1988	When porcine thyroid cells were cultured with TSH for 3 days in the presence of TGF-beta, TSH-induced iodide uptake and organification were reduced at rates that were dependent on the TGF-beta concentrations.	Iodides	102-108	transforming growth factor beta 1	Homo sapiens	184-192
3379138-2	1988	In this study, we tested the thyrotropic activity of purified and commercial hCG and compared its action with that of bovine TSH (bTSH) in cultured rat FRTL-5 cells in regard to stimulation of iodide uptake, activation of adenylate cyclase, and synthesis of DNA.	Iodides	193-199	hypertrichosis 2 (generalised, congenital)	Homo sapiens	77-80
3379138-6	1988	Both purified and commercial hCG produced a dose-related increase in iodide uptake.	Iodides	69-75	hypertrichosis 2 (generalised, congenital)	Homo sapiens	29-32
3379138-9	1988	The effect of hCG on iodide uptake and [3H]thymidine incorporation was additive with that of bTSH; hCG was not an antagonist of TSH in these cultured rat thyroid cells.	Iodides	21-27	hypertrichosis 2 (generalised, congenital)	Homo sapiens	14-17
3379138-10	1988	We conclude that hCG has intrinsic thyrotropic activity in FRTL-5 cells in regard to stimulation of iodide uptake, activation of adenylate cyclase, and stimulation of DNA synthesis.	Iodides	100-106	hypertrichosis 2 (generalised, congenital)	Homo sapiens	17-20
2454886-4	1988	Furthermore, these aAbs can inhibit, to varying degrees, the enzymatic activity of solubilized preparations of TPO in microsomes, as ascertained by peroxidation of guaiacol and iodide.	Iodides	177-183	thyroid peroxidase	Homo sapiens	111-114
3045192-7	1988	By increasing the incubation time of A14-125 I-insulin with monocytes a decrease of insulin peak (2 min: 38 +/- 18%; 15 min: 25 +/- 11%; 60 min: 6 +/- 4%) and a corresponding increase of iodide peak was observed.	Iodides	187-193	insulin	Homo sapiens	47-54
3045192-8	1988	Immunoprecipitability with anti-insulin antibody was 0% for iodide and a peaks, 60% for peak b, 78% for peak c and 90% for A14-insulin peak.	Iodides	60-66	insulin	Homo sapiens	32-39
2893362-6	1987	This shows that the transport of Tyr-MIF-1 is closely coupled to the transport of methionine enkephalin but dissociable from the brain to blood transport of iodide.	Iodides	157-163	predicted gene 4924	Mus musculus	37-42
3618770-8	1987	Comparison of iodine fluxes through the apical and basolateral membrane of the epithelial cell shows that an increase in plasma iodide concentration is correlated to a decrease of the Tg iodination and endocytotic fluxes (45%).	Iodides	128-134	thyroglobulin	Rattus norvegicus	184-186
2840263-9	1988	TGF-beta decreased iodide uptake stimulated by forskolin or 8-bromo-cAMP.	Iodides	19-25	transforming growth factor beta 1	Homo sapiens	0-8
2852626-1	1988	Myeloperoxidase was found to promote peroxidation of phospholipids under acidic conditions in the presence of hydrogen peroxide and iodide ions.	Iodides	132-138	myeloperoxidase	Homo sapiens	0-15
3425162-1	1987	The presence of thyroid stimulating activity in partially purified hCG was investigated using, as bioassay system, iodide uptake in rat thyroid FRTL-5 cells.	Iodides	115-121	hypertrichosis 2 (generalised, congenital)	Homo sapiens	67-70
3036482-2	1987	The addition of a high dose of iodide (10(-4) M) to such cultures caused a marked increase in c-myc mRNA levels, [3H]thymidine incorporation, and mitotic activity.	Iodides	31-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
2440424-11	1987	absorption and iodide quenching of the tryptophan fluorescence of human alpha 2M showed that one or two tryptophan residues in each alpha 2M monomer are buried on reaction with methylamine or trypsin, with no discernible change in the exposure of tyrosine residues.	Iodides	15-21	alpha-2-macroglobulin	Homo sapiens	72-80
3498156-1	1987	It is known that epidermal growth factor (EGF) inhibits iodide uptake in the thyroid follicular cells and lowers plasma levels of thyroid hormones upon infusion into sheep and ewes.	Iodides	56-62	EGF	Ovis aries	17-40
3498156-1	1987	It is known that epidermal growth factor (EGF) inhibits iodide uptake in the thyroid follicular cells and lowers plasma levels of thyroid hormones upon infusion into sheep and ewes.	Iodides	56-62	EGF	Ovis aries	42-45
3569125-11	1987	In marked contrast with iodide-induced Tg antibodies, the Tg antibodies accompanying the severe and early-onset thyroiditis of obese strain chickens are to a large degree independent of dietary iodine intake.	Iodides	24-30	thyroglobulin	Gallus gallus	39-41
3100285-0	1987	Norepinephrine and thyrotropin stimulation of iodide efflux in FRTL-5 thyroid cells involves metabolites of arachidonic acid and is associated with the iodination of thyroglobulin.	Iodides	46-52	thyroglobulin	Rattus norvegicus	166-179
3100285-1	1987	Ca2+-dependent and TSH-, norepinephrine (NE)-, and A23187-induced iodide (I-) efflux from FRTL-5 rat thyroid cells is inhibited by quinacrine and trifluoroperazine, agents that inhibit phospholipase A2 activity.	Iodides	66-72	phospholipase A2 group IB	Rattus norvegicus	185-201
2430627-4	1986	Dynamic quenching of the conjugated pyrene moiety by acrylamide, and iodide ions is markedly reduced upon reaction of the protease with alpha 2-macroglobulin, indicating a reduced accessibility of the protease active center in the complex.	Iodides	69-75	alpha-2-macroglobulin	Homo sapiens	136-157
3029204-8	1987	This effect was time and EPO dose dependent and was enhanced by the addition of iodide.	Iodides	80-86	eosinophil peroxidase	Homo sapiens	25-28
3814149-0	1987	Irreversible inactivation of lactoperoxidase in the course of iodide oxidation.	Iodides	62-68	lactoperoxidase	Homo sapiens	29-44
3030848-4	1987	EGF (10 ng/ml) induces a loss of thyrotropin (TSH) receptors with a time course identical to the loss in ability to transport iodide.	Iodides	126-132	epidermal growth factor	Homo sapiens	0-3
3030848-6	1987	Reciprocal plot analysis of iodide uptake in control and EGF-treated cells shows that EGF increases the Km for iodide transport, corresponding to a decreased affinity of iodide pump sites for iodide.	Iodides	28-34	epidermal growth factor	Homo sapiens	57-60
3030848-6	1987	Reciprocal plot analysis of iodide uptake in control and EGF-treated cells shows that EGF increases the Km for iodide transport, corresponding to a decreased affinity of iodide pump sites for iodide.	Iodides	28-34	epidermal growth factor	Homo sapiens	86-89
3030848-6	1987	Reciprocal plot analysis of iodide uptake in control and EGF-treated cells shows that EGF increases the Km for iodide transport, corresponding to a decreased affinity of iodide pump sites for iodide.	Iodides	111-117	epidermal growth factor	Homo sapiens	57-60
3030848-6	1987	Reciprocal plot analysis of iodide uptake in control and EGF-treated cells shows that EGF increases the Km for iodide transport, corresponding to a decreased affinity of iodide pump sites for iodide.	Iodides	111-117	epidermal growth factor	Homo sapiens	86-89
3030848-6	1987	Reciprocal plot analysis of iodide uptake in control and EGF-treated cells shows that EGF increases the Km for iodide transport, corresponding to a decreased affinity of iodide pump sites for iodide.	Iodides	111-117	epidermal growth factor	Homo sapiens	57-60
3030848-6	1987	Reciprocal plot analysis of iodide uptake in control and EGF-treated cells shows that EGF increases the Km for iodide transport, corresponding to a decreased affinity of iodide pump sites for iodide.	Iodides	111-117	epidermal growth factor	Homo sapiens	86-89
3030848-6	1987	Reciprocal plot analysis of iodide uptake in control and EGF-treated cells shows that EGF increases the Km for iodide transport, corresponding to a decreased affinity of iodide pump sites for iodide.	Iodides	111-117	epidermal growth factor	Homo sapiens	57-60
3030848-6	1987	Reciprocal plot analysis of iodide uptake in control and EGF-treated cells shows that EGF increases the Km for iodide transport, corresponding to a decreased affinity of iodide pump sites for iodide.	Iodides	111-117	epidermal growth factor	Homo sapiens	86-89
2433278-6	1987	The inhibitory properties of the salivary isozyme resemble those of CA II with iodide, sulfanilamide, and bromopyruvic acid, but the salivary enzyme is less sensitive to acetazolamide and methazolamide than CA II.	Iodides	79-85	carbonic anhydrase 2	Homo sapiens	68-73
3783276-3	1986	Iodination and separation of bound and free iodide, using AG1-X8 ion exchange resin, are both accomplished in this vial.	Iodides	44-50	NBPF member 10	Homo sapiens	58-61
2430744-7	1986	Studies on the inhibition of TPO by IgG isolated from sera of patients using guaiacol and iodide assays revealed that at least three epitopes of TPO molecule were recognized by autoantibodies and that the antigenic determinants on TPO molecule recognized by autoantibodies could be heterogeneous in patients.	Iodides	90-96	thyroid peroxidase	Homo sapiens	29-32
2430744-7	1986	Studies on the inhibition of TPO by IgG isolated from sera of patients using guaiacol and iodide assays revealed that at least three epitopes of TPO molecule were recognized by autoantibodies and that the antigenic determinants on TPO molecule recognized by autoantibodies could be heterogeneous in patients.	Iodides	90-96	thyroid peroxidase	Homo sapiens	145-148
2430744-7	1986	Studies on the inhibition of TPO by IgG isolated from sera of patients using guaiacol and iodide assays revealed that at least three epitopes of TPO molecule were recognized by autoantibodies and that the antigenic determinants on TPO molecule recognized by autoantibodies could be heterogeneous in patients.	Iodides	90-96	thyroid peroxidase	Homo sapiens	145-148
2425843-6	1986	MA1 and MA3 inhibit MPO activities such as tetraguaiacol formation, iodide oxidation and luminol-dependent chemiluminescence, while MB1 shows no such inhibition.	Iodides	68-74	PNMA family member 1	Homo sapiens	0-3
3015617-1	1986	In the presence of iodide (I-, 10 mM) and hydrogen peroxide in a large excess (H2O2, 0.1-10 mM) catalytic amounts of lactoperoxidase (2 nM) are very rapidly irreversibly inactivated without forming compound III (cpd III).	Iodides	19-25	lactoperoxidase	Homo sapiens	117-132
3016020-9	1986	Purified TPO was very stable at alkaline pH, and its ability to catalyze iodide oxidation and tyrosine iodination was increased to the same extent as its ability to catalyze guaiacol oxidation.	Iodides	73-79	thyroid peroxidase	Homo sapiens	9-12
2425843-6	1986	MA1 and MA3 inhibit MPO activities such as tetraguaiacol formation, iodide oxidation and luminol-dependent chemiluminescence, while MB1 shows no such inhibition.	Iodides	68-74	PNMA family member 3	Homo sapiens	8-11
2425843-6	1986	MA1 and MA3 inhibit MPO activities such as tetraguaiacol formation, iodide oxidation and luminol-dependent chemiluminescence, while MB1 shows no such inhibition.	Iodides	68-74	myeloperoxidase	Homo sapiens	20-23
3698909-0	1986	Evidence, by in vitro enzymatic iodination of thyroglobulin, that the efficiency of coupling is determined by the initial iodide concentration.	Iodides	122-128	thyroglobulin	Homo sapiens	46-59
3698909-9	1986	Provided that initially nonlimiting noninhibiting H2O2 and iodide concentrations are used and that iodination and coupling are allowed to proceed to completion, the extent of coupling is a function of the degree of iodination of Tgb achieved, and its efficiency is determined not just by the native structure of Tgb, but also by the initial iodide concentration used.	Iodides	59-65	thyroglobulin	Homo sapiens	229-232
3698909-9	1986	Provided that initially nonlimiting noninhibiting H2O2 and iodide concentrations are used and that iodination and coupling are allowed to proceed to completion, the extent of coupling is a function of the degree of iodination of Tgb achieved, and its efficiency is determined not just by the native structure of Tgb, but also by the initial iodide concentration used.	Iodides	341-347	thyroglobulin	Homo sapiens	229-232
2418616-8	1985	The exit rate constant of free iodide for the various doses showed values from 0.048 to 0.055 min-1.	Iodides	31-37	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
3000588-7	1986	Moreover like EGF, phorbol esters strongly inhibited in 2 days the morphological effects of TSH and basal and TSH-stimulated iodide transport capacity and thyroglobulin messenger RNA accumulation, two markers of thyroid differentiation.	Iodides	125-131	epidermal growth factor	Canis lupus familiaris	14-17
3763824-2	1986	The effect of iodide ion on the tryptophyl fluorescence of the homologous proteins lysozyme and alpha-lactalbumin in their native form, as well as in their modified structures and in fragments from these proteins was studied.	Iodides	14-20	lactalbumin alpha	Homo sapiens	96-113
3964650-4	1986	The quenching of LpL fluorescence by acrylamide and iodide ion was decreased only slightly by addition of C14-ether-PC vesicles.	Iodides	52-58	lipoprotein lipase	Homo sapiens	17-20
6197095-4	1983	TRH also stimulated iodide binding to proteins, but not cyclic GMP accumulation.	Iodides	20-26	TRH	Canis lupus familiaris	0-3
3988738-3	1985	Fluorescence emission spectra of apo-A-IV in dilute aqueous solution revealed that its single tryptophan residue resides in a pH-sensitive hydrophobic domain, which is maximally protected from iodide quenching at pH 7.5.	Iodides	193-199	apolipoprotein A4	Homo sapiens	33-41
2982588-1	1985	The activity of thyroid peroxidase (TPO) in primary dog thyroid cell cultures was measured by both guaiacol oxidation and iodide oxidation assays.	Iodides	122-128	thyroid peroxidase	Canis lupus familiaris	16-34
2982588-1	1985	The activity of thyroid peroxidase (TPO) in primary dog thyroid cell cultures was measured by both guaiacol oxidation and iodide oxidation assays.	Iodides	122-128	thyroid peroxidase	Canis lupus familiaris	36-39
6745222-7	1984	DBA mice had an increased concentration of iodide in CSF, an indication that they have a defect in the transport of iodide out of the CSF across the choroid plexus.	Iodides	116-122	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	53-56
6745222-7	1984	DBA mice had an increased concentration of iodide in CSF, an indication that they have a defect in the transport of iodide out of the CSF across the choroid plexus.	Iodides	116-122	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	134-137
6745222-8	1984	In addition, DBA mice had a lower ratio of cerebral cortex to CSF iodide, which suggests that DBA mice have a defect in the transport of this anion into cerebral cortical cells from brain interstitial fluid.	Iodides	66-72	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	62-65
2996887-12	1985	Culture of cells in the presence of EGF for 4-6 days affected profoundly their morphology, abolished iodide trapping and decreased thyroglobulin synthesis and cytoplasmic mRNA content to undetectable levels.	Iodides	101-107	epidermal growth factor	Canis lupus familiaris	36-39
2981925-18	1985	Using 125I, we found that exposure of liposomes to the MPO system resulted in an association between iodide and liposomes; moreover, there was a close correspondence between this phenomenon and 51Cr release, suggesting that halogenation may be one mechanism of injury.	Iodides	101-107	myeloperoxidase	Homo sapiens	55-58
3882481-1	1985	In the adenocarcinoma cell line HT-29 receptor-bound insulin is substrate for a proteolytic process leading to the release of about half of the cell-associated [125I]monoiodoinsulin in the form of [125I]iodide and [125I]monoiodotyrosine.	Iodides	203-209	insulin	Homo sapiens	53-60
6745222-7	1984	DBA mice had an increased concentration of iodide in CSF, an indication that they have a defect in the transport of iodide out of the CSF across the choroid plexus.	Iodides	43-49	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	53-56
6745222-7	1984	DBA mice had an increased concentration of iodide in CSF, an indication that they have a defect in the transport of iodide out of the CSF across the choroid plexus.	Iodides	43-49	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	134-137
6197095-6	1983	The possibility of a TRH action through other known inhibitors of the cyclic AMP system in dog thyroid such as: acetylcholine, alpha-adrenergic agents, adenosine, iodide were checked and ruled out.	Iodides	163-169	TRH	Canis lupus familiaris	21-24
6882356-1	1983	Cathepsin D inactivated aldolase at pH values between 4.2 and 5.2; the chloride, sulphate or iodide, but not citrate or acetate, salts of sodium or potassium accelerated the rate of inactivation.	Iodides	93-99	cathepsin D	Homo sapiens	0-11
6659844-4	1983	The addition of all the hormones used - insulin, hydrocortisone and thyrotrophic hormone - had a synergistic effect on the iodide trapping ability of the culture system.	Iodides	123-129	LOC105613195	Ovis aries	40-47
6861708-1	1983	We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide.	Iodides	246-252	thyroid peroxidase	Rattus norvegicus	147-165
6301581-4	1983	Myeloperoxidase (MPO) in the ID-PMN population showed increased sensitivity to inhibition by 3-amino-1,2,4-triazole, and HD-PMN exhibited a 2-3-fold increase in chloride and iodide oxidation per unit of MPO activity compared to ID-PMN.	Iodides	174-180	myeloperoxidase	Homo sapiens	0-15
6301581-4	1983	Myeloperoxidase (MPO) in the ID-PMN population showed increased sensitivity to inhibition by 3-amino-1,2,4-triazole, and HD-PMN exhibited a 2-3-fold increase in chloride and iodide oxidation per unit of MPO activity compared to ID-PMN.	Iodides	174-180	myeloperoxidase	Homo sapiens	17-20
6601001-6	1983	EGF added at the same concentrations that stimulated incorporation of [3H]thymidine was found to reduce iodide metabolism of the follicles within 30 min of addition; both TSH-stimulated efflux and organification of [125I]iodide were suppressed by the addition of EGF.	Iodides	104-110	epidermal growth factor	Homo sapiens	0-3
6847836-3	1983	1) TPO is inactivated by 1-methyl-2-mercaptoimidazole and propylthiouracil even in the presence of a relatively high concentration of iodide.	Iodides	134-140	thyroid peroxidase	Homo sapiens	3-6
6299966-7	1983	These results suggest that iodide fixation by PMN and low numbers of fungal cells may reflect a cooperative effort, with fungi generating some H2O2 that reacts with the myeloperoxidase released from the PMN.	Iodides	27-33	myeloperoxidase	Mus musculus	169-184
6337399-4	1983	After previous saturation of the insulin receptor compartment, [123I]insulin was concentrated by the kidneys only and the rate of appearance of free iodide was markedly decreased.	Iodides	149-155	insulin receptor	Homo sapiens	33-49
6337399-4	1983	After previous saturation of the insulin receptor compartment, [123I]insulin was concentrated by the kidneys only and the rate of appearance of free iodide was markedly decreased.	Iodides	149-155	insulin	Homo sapiens	33-40
6847661-0	1983	Iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.	Iodides	0-6	thyroid peroxidase	Homo sapiens	39-57
6847661-0	1983	Iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.	Iodides	0-6	lactoperoxidase	Homo sapiens	62-77
6847661-1	1983	Thyroid peroxidase (TPO) and lactoperoxidase (LPO) display significant catalatic activity at pH 7.0 in the presence of low concentrations of iodide, based both on measurements of H2O2 disappearance and O2 evolution.	Iodides	141-147	thyroid peroxidase	Homo sapiens	0-18
6847661-1	1983	Thyroid peroxidase (TPO) and lactoperoxidase (LPO) display significant catalatic activity at pH 7.0 in the presence of low concentrations of iodide, based both on measurements of H2O2 disappearance and O2 evolution.	Iodides	141-147	thyroid peroxidase	Homo sapiens	20-23
6847661-1	1983	Thyroid peroxidase (TPO) and lactoperoxidase (LPO) display significant catalatic activity at pH 7.0 in the presence of low concentrations of iodide, based both on measurements of H2O2 disappearance and O2 evolution.	Iodides	141-147	lactoperoxidase	Homo sapiens	29-44
6847661-1	1983	Thyroid peroxidase (TPO) and lactoperoxidase (LPO) display significant catalatic activity at pH 7.0 in the presence of low concentrations of iodide, based both on measurements of H2O2 disappearance and O2 evolution.	Iodides	141-147	lactoperoxidase	Homo sapiens	46-49
6295926-5	1983	The target cell destruction required the presence of the iodide ion as oxidizable co-factor for the myeloperoxidase-hydrogen peroxide system.	Iodides	57-63	myeloperoxidase	Homo sapiens	100-115
7042313-7	1982	Since in hypophysectomized rats, the recycling of iodide is abolished, it is concluded that in normal rats: 1) transported iodide is organified mainly by direct iodination of newly synthesized Tg, independently of TSH, and 2) internal iodide is organified mainly by delayed iodination of preexisting Tg, this process being TSH dependent.	Iodides	123-129	thyroglobulin	Rattus norvegicus	193-195
7042313-7	1982	Since in hypophysectomized rats, the recycling of iodide is abolished, it is concluded that in normal rats: 1) transported iodide is organified mainly by direct iodination of newly synthesized Tg, independently of TSH, and 2) internal iodide is organified mainly by delayed iodination of preexisting Tg, this process being TSH dependent.	Iodides	123-129	thyroglobulin	Rattus norvegicus	300-302
7042313-7	1982	Since in hypophysectomized rats, the recycling of iodide is abolished, it is concluded that in normal rats: 1) transported iodide is organified mainly by direct iodination of newly synthesized Tg, independently of TSH, and 2) internal iodide is organified mainly by delayed iodination of preexisting Tg, this process being TSH dependent.	Iodides	123-129	thyroglobulin	Rattus norvegicus	193-195
7042313-7	1982	Since in hypophysectomized rats, the recycling of iodide is abolished, it is concluded that in normal rats: 1) transported iodide is organified mainly by direct iodination of newly synthesized Tg, independently of TSH, and 2) internal iodide is organified mainly by delayed iodination of preexisting Tg, this process being TSH dependent.	Iodides	123-129	thyroglobulin	Rattus norvegicus	300-302
6282905-4	1982	Bromide and iodide were much more effective than chloride in the myeloperoxidase-mediated oxidation of methionine.	Iodides	12-18	myeloperoxidase	Canis lupus familiaris	65-80
7041980-4	1982	Horse eosinophil peroxidase is a strongly basic protein with bacterial properties when combined with H2O2 and iodide, bromide or, to a lesser degree, chloride.	Iodides	110-116	eosinophil peroxidase	Equus caballus	6-27
6177452-0	1982	[Reciprocal changes in serum TBG and T4 in hyperthyroidism treated with PTU and iodide (author"s transl)].	Iodides	80-86	serpin family A member 7	Homo sapiens	29-32
7036631-0	1982	Susceptibility to proteolysis of thyroglobulin from rats and guinea-pigs treated with excess iodide.	Iodides	93-99	thyroglobulin	Rattus norvegicus	33-46
7036631-1	1982	The effect of excess iodide on proteolysis of in vivo 125I-labelled thyroglobulin (Tg) from rats and guinea-pigs was investigated in vitro using preparations of thyroid lysosomes and exogenous proteases (Pronase).	Iodides	21-27	thyroglobulin	Rattus norvegicus	68-81
6176177-3	1981	The mechanism of the antithyroid action of SCN at low concentrations, lies in an acceleration of the exit rate of thyroidal iodide; this effect cannot be identified by the usual clinical investigation with Iodine131.	Iodides	124-130	sorcin	Homo sapiens	43-46
7068574-7	1982	From these changes and also changes in CD spectra, we deduced that fluoride, chloride, and bromide ions can bind with heme iron of the catalase molecule as ligands to form stable catalase-halide complexes, but iodide ions showed a different reactivity with catalase from other halides and may cause gross alteration in the structure or conformation of catalase.	Iodides	210-216	catalase	Homo sapiens	135-143
6272517-3	1981	In the chronic experiments beta-glycerophosphatase and cathepsin D activities increased with the iodide supply of the animals up to 100 micrograms I/rat and decreased slightly thereafter.	Iodides	97-103	cathepsin D	Rattus norvegicus	55-66
7287752-5	1981	The rate constant for dissociation of the antithrombin-heparin complex is 1.1-1.5 s-1 at mu 0.15, as determined from the ordinate intercept at low heparin concentrations or by dissociation of the antithrombin-heparin complex with iodide.	Iodides	230-236	serpin family C member 1	Homo sapiens	42-54
6266056-4	1981	Using an in vivo model system it has been shown that MPO catalyses the sequential events of iodination, iodine exchange and de-iodination of tyrosines and, furthermore, that all three reactions are influenced by the rate of H2O2 generation and the iodide concentration of the reaction medium.	Iodides	248-254	myeloperoxidase	Homo sapiens	53-56
6267713-1	1981	Thyroid peroxidase in involved in several steps of the biosynthesis of thyroid hormone utilizing H2O2: peroxidation of iodide to iodine, iodination of thyroglobulin (Tg) and coupling reaction leading to T4 and T3 formation.	Iodides	119-125	thyroglobulin	Homo sapiens	151-164
6260684-9	1981	A sample of a very highly purified human myeloperoxidase functioned in the presence of hydrogen peroxide and either iodide or chloride to prevent germination of both blastospores and conidiospores.	Iodides	116-122	myeloperoxidase	Homo sapiens	41-56
6256441-5	1981	Canine neutrophil peroxidase (myeloperoxidase [MPO]) was also able to kill schistosomula in vitro in the presence of 10(-4) M H2O2 and 10(-4) iodide at pH 7.0 and pH 6.0.	Iodides	142-148	myeloperoxidase	Canis lupus familiaris	30-45
6787360-1	1981	In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo-delta-lactone.	Iodides	19-25	lactoperoxidase	Homo sapiens	49-64
6256441-5	1981	Canine neutrophil peroxidase (myeloperoxidase [MPO]) was also able to kill schistosomula in vitro in the presence of 10(-4) M H2O2 and 10(-4) iodide at pH 7.0 and pH 6.0.	Iodides	142-148	myeloperoxidase	Canis lupus familiaris	47-50
6772675-3	1980	TSH regulation was studied by measuring the TSH response to injected thyrotropin-releasing hormone (TRH) before and after effecting a small decrease in serum thyroxine (T(4)) and/or T(3) concentrations by iodide treatment, 262 mg daily for 10 d. Iodide treatment significantly decreased (> 10%) the free T(4) index (FT(4)-I) and/or free T(3) index (FT(3)-I) in all patients.	Iodides	205-211	thyrotropin releasing hormone	Homo sapiens	69-98
6987309-1	1980	A partially purified preparation of guinea pig eosinophil peroxidase was found to be bactericidal when combined with H2O2 and either iodide, bromide, chloride, or thiocyanate ions.	Iodides	133-139	eosinophil peroxidase	Cavia porcellus	47-68
6156983-6	1980	When the EPO level was increased to 100 mU, combination with H2O2- and iodide-induced cytotoxic histamine release as indicated by concomitant LDH release and ultrastructural evidence of cell disruption.	Iodides	71-77	eosinophil peroxidase	Homo sapiens	9-12
6156983-9	1980	The mast cell granule (MCG)/EPO complex when supplemented with H2O2 and iodide was more effective than free EPO in the stimulation of mast cell secretion.	Iodides	72-78	eosinophil peroxidase	Homo sapiens	28-31
6987309-3	1980	When the EPO concentration of the reaction mixture was lowered, the bactericidal effect at pH 7.0 was lost first with chloride, then with bromide, and finally with iodide as the halide.	Iodides	164-170	erythropoietin	Cavia porcellus	9-12
510218-2	1979	After the suppression of TSH by hypophysectomy, only the captured iodide is used for iodination of thyroglobulin, the iodide recycling being abolished.	Iodides	66-72	thyroglobulin	Rattus norvegicus	99-112
6987310-4	1980	The MCG/EPO complex retained the capacity of the isolated EPO to catalyze the iodination reaction when supplemented with iodide, H2O2, and a protein acceptor and to kill microorganisms when supplemented with H2O2 and a halide (iodide, chloride).	Iodides	121-127	eosinophil peroxidase	Homo sapiens	8-11
6987310-4	1980	The MCG/EPO complex retained the capacity of the isolated EPO to catalyze the iodination reaction when supplemented with iodide, H2O2, and a protein acceptor and to kill microorganisms when supplemented with H2O2 and a halide (iodide, chloride).	Iodides	121-127	eosinophil peroxidase	Homo sapiens	58-61
6987310-4	1980	The MCG/EPO complex retained the capacity of the isolated EPO to catalyze the iodination reaction when supplemented with iodide, H2O2, and a protein acceptor and to kill microorganisms when supplemented with H2O2 and a halide (iodide, chloride).	Iodides	227-233	eosinophil peroxidase	Homo sapiens	8-11
6987310-4	1980	The MCG/EPO complex retained the capacity of the isolated EPO to catalyze the iodination reaction when supplemented with iodide, H2O2, and a protein acceptor and to kill microorganisms when supplemented with H2O2 and a halide (iodide, chloride).	Iodides	227-233	eosinophil peroxidase	Homo sapiens	58-61
7372897-0	1980	Chronic iodine toxicity in dairy cattle: blood chemistry, leukocytes, and milk iodide.	Iodides	79-85	Weaning weight-maternal milk	Bos taurus	74-78
7372897-4	1980	Milk iodide averaged .37 +/- .03 ppm from normal and 2.16 +/- .25 from herds fed high iodide.	Iodides	5-11	Weaning weight-maternal milk	Bos taurus	0-4
7372897-5	1980	Neutrophils, glucose, protein, and globulin of serum increased while lymphocytes, cholesterol, and thyroxine decreased as iodide in milk and urine increased.	Iodides	122-128	Weaning weight-maternal milk	Bos taurus	132-136
436767-5	1979	In the presence of iodide, the iodinating species [TPO.Ioxid], oxidizes thiourea to formamidine disulfide.	Iodides	19-25	thyroid peroxidase	Rattus norvegicus	51-54
226345-7	1979	Cholera toxin stimulation of ODC was inhibited by indomethacin or iodide as are the stimulatory effects of TSH or dibutyryl cyclic AMP.	Iodides	66-72	ornithine decarboxylase 1	Rattus norvegicus	29-32
89704-7	1979	On the other hand, 125I incorporation into 131I-DIT was not affected by increased concentrations of MMI up to 10(-5)M. At higher drug concentrations the drug caused inhibition of MPO-catalysed exchange of inorganic iodide for organic iodine in DIT.	Iodides	215-221	myeloperoxidase	Homo sapiens	179-182
34612-1	1979	Glutathione and cysteine bind to the heme of lactoperoxidase, thereby causing a red shift of the Soret band which is reversed upon addition of iodide or guaiacol, two substrates for lactoperoxidase.	Iodides	143-149	lactoperoxidase	Homo sapiens	45-60
34612-1	1979	Glutathione and cysteine bind to the heme of lactoperoxidase, thereby causing a red shift of the Soret band which is reversed upon addition of iodide or guaiacol, two substrates for lactoperoxidase.	Iodides	143-149	lactoperoxidase	Homo sapiens	182-197
510218-2	1979	After the suppression of TSH by hypophysectomy, only the captured iodide is used for iodination of thyroglobulin, the iodide recycling being abolished.	Iodides	118-124	thyroglobulin	Rattus norvegicus	99-112
211044-2	1978	The neutrophils exhibited a marked decrease in phagocytosis after 1 h. The myeloperoxidase mediated conversion of iodide to a protein-bound form was also decreased.	Iodides	114-120	myeloperoxidase	Homo sapiens	75-90
744122-5	1978	Preincubation, as above, in the presence of iodide or thiocyanate prevented the irreversible inactivation of TPO.	Iodides	44-50	thyroid peroxidase	Rattus norvegicus	109-112
597266-5	1977	A very strong inhibition of iodide ;uptake" from Na(131)I, caused by thiosulphate, produced only a minor inhibition of the incorporation of (125)I from (125)I-labelled liposomes into thyroid protein and/or thyroglobulin.	Iodides	28-34	thyroglobulin	Canis lupus familiaris	206-219
599152-9	1977	The quenching of apo-RBP fluorescence, probably the fluorescence of tryptophanyl residues, by iodide anions and cesium cations was measured.	Iodides	94-100	retinol binding protein 4	Homo sapiens	21-24
599152-10	1977	The fluorescence of apo-RBP in the presence of 4 M Gu-HCl was quenched considerably by iodide and cesium, and Stern-Volmer plots were linear.	Iodides	87-93	retinol binding protein 4	Homo sapiens	24-27
599152-11	1977	However, the fluorescence of native apo-RBP was scarcely quenched by iodide or cesium.	Iodides	69-75	retinol binding protein 4	Homo sapiens	40-43
225142-2	1978	After phagocytosis, MPO is released into the phagosome from adjacent granules where it interacts with H2O2 generated either by leukocytic or microbial metabolism and a halide such as chloride or iodide to form agents toxic to the ingested organisms.	Iodides	195-201	myeloperoxidase	Homo sapiens	20-23
947933-3	1976	PTU interacted directly with the product of TPO action (oxidized iodide) in the reaction mixture without significantly affecting TPO activity.	Iodides	65-71	thyroid peroxidase	Homo sapiens	44-47
199598-1	1977	Iodination of horse cytochrome c with the lactoperoxidase-hydrogen peroxide-iodide system results initially in the formation of the monoiodotyrosyl 74 derivative.	Iodides	76-82	cytochrome c, somatic	Equus caballus	20-32
199598-1	1977	Iodination of horse cytochrome c with the lactoperoxidase-hydrogen peroxide-iodide system results initially in the formation of the monoiodotyrosyl 74 derivative.	Iodides	76-82	lactoperoxidase	Equus caballus	42-57
192613-11	1977	At iodide equilibrium, thryotropin, prostaglandins E1 and E2 and long-acting thyroid stimulator (LATS), induce a fast release of iodide.	Iodides	3-9	cystatin 12, pseudogene	Homo sapiens	58-95
192613-11	1977	At iodide equilibrium, thryotropin, prostaglandins E1 and E2 and long-acting thyroid stimulator (LATS), induce a fast release of iodide.	Iodides	129-135	cystatin 12, pseudogene	Homo sapiens	58-95
1022721-0	1976	Iodide, thiocyanate and cyanide ions as capturing reagents in one-step copper-thiocholine method for cytochemical localization of cholinesterase activity.	Iodides	0-6	butyrylcholinesterase	Rattus norvegicus	130-144
821840-1	1976	The effects of prolonged administration of iodide upon the serum concentrations of thyrotropin (TSH), thyroxine (T4), and triiodothyronine (T3) and their response to thyrotropin releasing hormone (TRH, 400 mug i.v.)	Iodides	43-49	thyrotropin releasing hormone	Homo sapiens	166-195
821840-3	1976	Administration of iodide (25 mg daily for two weeks) increased in healthy subjects the basal concentrations of TSH and the release of TSH in response to TRH (p less than 0.05-0.01).	Iodides	18-24	thyrotropin releasing hormone	Homo sapiens	153-156
24016-0	1977	Quenching of tryptophan fluorescence in human antithrombin III by iodide ion.	Iodides	66-72	serpin family C member 1	Homo sapiens	46-62
24016-1	1977	Iodide is an efficient quencher of antithrombin III intrinsic tryptophan fluorescence.	Iodides	0-6	serpin family C member 1	Homo sapiens	35-51
20445-2	1977	Neurotensin was iodinated at equimolar concentrations of peptide, iodide, and chloramine-T, producing a labeled peptide with a specific activity of 1000 to 2000 Ci/mmol.	Iodides	66-72	neurotensin	Rattus norvegicus	0-11
8096-10	1976	Iodide quenched 50% of the fluorescence of the deuteroheme-hemopexin complex.	Iodides	0-6	hemopexin	Oryctolagus cuniculus	59-68
1278093-5	1976	2) The thioureylene drugs are also potent inhibitors of TPO-catalyzed oxidation of guaiacol, a reaction that does not involve iodide.	Iodides	126-132	thyroid peroxidase	Homo sapiens	56-59
3284-0	1976	Quenching of tryptophanyl fluorescence of human growth hormone by iodide.	Iodides	66-72	growth hormone 1	Homo sapiens	48-62
816092-0	1975	[The effect of iodide on the TRH-induced release of HTSH, T4 and T3 in euthyroid subjects (author"s transl)].	Iodides	15-21	thyrotropin releasing hormone	Homo sapiens	29-32
1262432-7	1976	Both P-TPO and G2-TPO catalyzed iodide peroxidation (I- leads to I2) but the Km (iodide) value for G2-TPO was much lower (2.3 x 10(-2) M) when compared with that of P-TPO (3.7 x 10(-3) M) or G1-TPO (3.5 x 10(-3) M).	Iodides	32-38	thyroid peroxidase	Homo sapiens	7-10
1262432-7	1976	Both P-TPO and G2-TPO catalyzed iodide peroxidation (I- leads to I2) but the Km (iodide) value for G2-TPO was much lower (2.3 x 10(-2) M) when compared with that of P-TPO (3.7 x 10(-3) M) or G1-TPO (3.5 x 10(-3) M).	Iodides	32-38	thyroid peroxidase	Homo sapiens	18-21
1262432-7	1976	Both P-TPO and G2-TPO catalyzed iodide peroxidation (I- leads to I2) but the Km (iodide) value for G2-TPO was much lower (2.3 x 10(-2) M) when compared with that of P-TPO (3.7 x 10(-3) M) or G1-TPO (3.5 x 10(-3) M).	Iodides	32-38	thyroid peroxidase	Homo sapiens	18-21
1262432-7	1976	Both P-TPO and G2-TPO catalyzed iodide peroxidation (I- leads to I2) but the Km (iodide) value for G2-TPO was much lower (2.3 x 10(-2) M) when compared with that of P-TPO (3.7 x 10(-3) M) or G1-TPO (3.5 x 10(-3) M).	Iodides	32-38	thyroid peroxidase	Homo sapiens	18-21
1262432-7	1976	Both P-TPO and G2-TPO catalyzed iodide peroxidation (I- leads to I2) but the Km (iodide) value for G2-TPO was much lower (2.3 x 10(-2) M) when compared with that of P-TPO (3.7 x 10(-3) M) or G1-TPO (3.5 x 10(-3) M).	Iodides	32-38	thyroid peroxidase	Homo sapiens	18-21
1262432-7	1976	Both P-TPO and G2-TPO catalyzed iodide peroxidation (I- leads to I2) but the Km (iodide) value for G2-TPO was much lower (2.3 x 10(-2) M) when compared with that of P-TPO (3.7 x 10(-3) M) or G1-TPO (3.5 x 10(-3) M).	Iodides	81-87	thyroid peroxidase	Homo sapiens	7-10
1262432-7	1976	Both P-TPO and G2-TPO catalyzed iodide peroxidation (I- leads to I2) but the Km (iodide) value for G2-TPO was much lower (2.3 x 10(-2) M) when compared with that of P-TPO (3.7 x 10(-3) M) or G1-TPO (3.5 x 10(-3) M).	Iodides	81-87	thyroid peroxidase	Homo sapiens	18-21
1262432-7	1976	Both P-TPO and G2-TPO catalyzed iodide peroxidation (I- leads to I2) but the Km (iodide) value for G2-TPO was much lower (2.3 x 10(-2) M) when compared with that of P-TPO (3.7 x 10(-3) M) or G1-TPO (3.5 x 10(-3) M).	Iodides	81-87	thyroid peroxidase	Homo sapiens	18-21
1262432-7	1976	Both P-TPO and G2-TPO catalyzed iodide peroxidation (I- leads to I2) but the Km (iodide) value for G2-TPO was much lower (2.3 x 10(-2) M) when compared with that of P-TPO (3.7 x 10(-3) M) or G1-TPO (3.5 x 10(-3) M).	Iodides	81-87	thyroid peroxidase	Homo sapiens	18-21
1262432-7	1976	Both P-TPO and G2-TPO catalyzed iodide peroxidation (I- leads to I2) but the Km (iodide) value for G2-TPO was much lower (2.3 x 10(-2) M) when compared with that of P-TPO (3.7 x 10(-3) M) or G1-TPO (3.5 x 10(-3) M).	Iodides	81-87	thyroid peroxidase	Homo sapiens	18-21
816092-9	1975	The obtained data show that the prolonged ingestion of iodide induces a relatively hypothyroid state with an increased release of HTSH in response to the injection of TRH.	Iodides	55-61	thyrotropin releasing hormone	Homo sapiens	167-170
816092-11	1975	The Wolff-Chaikoff effect, which is induced by the administration of excess iodide, appears to be the cause of the observed increase in TSH secretion upon TRH administration in iodide-treated subjects.	Iodides	76-82	thyrotropin releasing hormone	Homo sapiens	155-158
816092-11	1975	The Wolff-Chaikoff effect, which is induced by the administration of excess iodide, appears to be the cause of the observed increase in TSH secretion upon TRH administration in iodide-treated subjects.	Iodides	177-183	thyrotropin releasing hormone	Homo sapiens	155-158
169912-3	1975	Thus, we have found that the 2--4-fold thyrotropin stimulation of protein iodination in beef thyroid cells was reduced about 30% by 4 h of preincubation with 10 muM iodide, and virtually abolished with 50 muM iodide.	Iodides	209-215	latexin	Homo sapiens	205-208
1212981-1	1975	The effect of excess iodide on hog thyroid gland has been examined with regard to the change in the chemical composition of thyroglobulin and in the accumulation of 27-S iodoprotein by the in vivo treatment of hogs with iodide for various lengths of time.	Iodides	21-27	thyroglobulin	Homo sapiens	124-137
1212981-2	1975	The iodine content of thyroglobulin was either unchanged by short term administration of excess iodide, or somewhat lowered.	Iodides	96-102	thyroglobulin	Homo sapiens	22-35
1212981-3	1975	However, the iodine content as well as the total amount of thyroglobulin increased in the glands enlarged by prolonged treatment with iodide.	Iodides	134-140	thyroglobulin	Homo sapiens	59-72
1212981-6	1975	Monoiodotyrosine and diiodotyrosine increased in parallel with the increase in the iodine content (0.15 to 1.17%) caused by the iodide treatment, while thyroxine increased but reached a plateau at the level of three residues per mole of thyroglobulin, and no change was observed even in the proteins with the higher iodine content than 0.75%.	Iodides	128-134	thyroglobulin	Homo sapiens	237-250
169912-4	1975	Similarly the 8-fold thyrotropin stimulation of cyclic AMP accumulation in the cells was reduced about 30% by 3 h of preincubation with 50 muM iodide.	Iodides	143-149	latexin	Homo sapiens	139-142
1190729-3	1975	With high iodide concentrations a highly iodinated thyroglobulin (40-50 iodine atoms) containing no thyroxine was obtained after 3 minutes of incubation.	Iodides	10-16	thyroglobulin	Homo sapiens	51-64
235316-1	1975	Quenching of the tryptophan fluorescence of pig serum HDL3 and LDL2 lipoproteins by iodide and succinimide has been used to estimate the accessibility of the fluorophores to the solvent and, by inference, the location of the protein in the macromolecular complexes.	Iodides	84-90	HDL3	Homo sapiens	54-58
1173052-3	1975	Myeloperoxidase can be replaced by lactoperoxidase in the iodide-, thyroxine and triiodothyronine-dependent, but not in the chloride-dependent, systems.	Iodides	58-64	myeloperoxidase	Homo sapiens	0-15
803974-3	1975	In contrast, TSH responses to TRH were significantly greater at the end of the iodide treatment period.	Iodides	79-85	thyrotropin releasing hormone	Homo sapiens	30-33
803974-5	1975	Post-TRH mean peak serum TSH concentrations were 14.2 muU/ml before and 27.4 muU/ml after iodide (P smaller than 0.01).	Iodides	90-96	thyrotropin releasing hormone	Homo sapiens	5-8
1173052-1	1975	Erythrocytes are hemolyzed by myeloperoxidase, an H2O2-generating system (glucose + glucose oxidase; hypoxanthine + xanthine oxidase) and an oxidizable cofactor (chloride, iodide, thyroxine, triiodothyronine).	Iodides	172-178	myeloperoxidase	Homo sapiens	30-45
4629909-1	1973	Thyroxine (T(4)) and triiodothyronine (T(9)) are rapidly degraded by a purified preparation of myeloperoxidase (MPO) and H(2)O(2) with the formation of iodide and material which remains at the origin on paper chromatography.	Iodides	152-158	myeloperoxidase	Homo sapiens	95-110
1120184-4	1975	Myeloperoxidase was effective with either chloride or iodide as the halide, while lastoperoxidase was effective with iodide but not chloride.	Iodides	54-60	myeloperoxidase	Homo sapiens	0-15
4214837-1	1974	To determine whether pituitary thyrotropin (TSH) responsiveness to thyrotropin-releasing hormone (TRH) is enhanced by small decreases in serum thyroxine (T4) and triiodothyronine (T3), 12 euthyroid volunteers were given 190 mg iodide po daily for 10 days to inhibit T4 and T3 release from the thyroid.	Iodides	227-233	thyrotropin releasing hormone	Homo sapiens	98-101
4214837-5	1974	During iodide administration, the TSH response to TRH was significantly increased at each of seven time points up to 120 min.	Iodides	7-13	thyrotropin releasing hormone	Homo sapiens	50-53
4214837-6	1974	The maximum increment in serum TSH after TRH increased from a control mean of 8.8+/-4.1 to a mean of 13.0+/-2.8 muU/ml during iodide administration.	Iodides	126-132	thyrotropin releasing hormone	Homo sapiens	41-44
4717124-1	1973	Lactoperoxidase, in the presence of hydrogen peroxide and iodide is cytotoxic for human and mouse lymphoid cells, and human erythrocytes.	Iodides	58-64	lactoperoxidase	Homo sapiens	0-15
4717124-2	1973	Myeloperoxidase, in amounts equivalent to 1.5 x 10(6) neutrophils, readily replaces lactoperoxidase, and allows the substitution of the iodide ion by chloride.	Iodides	136-142	myeloperoxidase	Homo sapiens	0-15
4629909-1	1973	Thyroxine (T(4)) and triiodothyronine (T(9)) are rapidly degraded by a purified preparation of myeloperoxidase (MPO) and H(2)O(2) with the formation of iodide and material which remains at the origin on paper chromatography.	Iodides	152-158	myeloperoxidase	Homo sapiens	112-115
4317722-1	1970	Lactoperoxidase (EC 1.11.1.7) catalysed the oxidation of NADH by hydrogen peroxide in the presence of either thiocyanate, iodide or bromide.	Iodides	122-128	lactoperoxidase	Homo sapiens	0-15
5528498-0	1970	Thyroid peroxidase-catalyzed iodination of thyroglobulin; inhibition by excess iodide.	Iodides	79-85	thyroid peroxidase	Homo sapiens	0-18
5119250-1	1971	The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.	Iodides	83-89	lysozyme	Homo sapiens	71-79
4964565-2	1967	Myeloperoxidase can be replaced in this system by lactoperoxidase or by a guinea pig leukocyte particulate preparation, H(2)O(2) by an H(2)O(2)-generating system such as glucose and glucose oxidase, and iodide by thyroxine or triiodothyronine.	Iodides	203-209	myeloperoxidase	Cavia porcellus	0-15
16557740-4	1970	Since we had previously found that myeloperoxidase (MPO), a lysosomal enzyme of human neutrophils and monocytes, exerted fungicidal activity against Candida albicans when combined with H(2)O(2) and chloride or iodide, the effects of these substances on A. fumigatus spores were examined.	Iodides	210-216	myeloperoxidase	Homo sapiens	35-50
16557740-4	1970	Since we had previously found that myeloperoxidase (MPO), a lysosomal enzyme of human neutrophils and monocytes, exerted fungicidal activity against Candida albicans when combined with H(2)O(2) and chloride or iodide, the effects of these substances on A. fumigatus spores were examined.	Iodides	210-216	myeloperoxidase	Homo sapiens	52-55
4970226-1	1968	An antibacterial effect of myeloperoxidase, a halide, such as iodide, bromide, or chloride ion, and H(2)O(2) on Escherichia coli or Lactobacillus acidophilus is described.	Iodides	62-68	myeloperoxidase	Cavia porcellus	27-42
6077809-0	1967	The selective quenching of tryptophan fluorescence in proteins by iodide ion: lysozyme in the presence and absence of substrate.	Iodides	66-72	lysozyme	Homo sapiens	78-86
4964565-6	1967	Iodination of the bacteria by the myeloperoxidase-iodide-H(2)O(2) system was demonstrated chemically and radioautographically.	Iodides	50-56	myeloperoxidase	Cavia porcellus	34-49
33974556-2	2021	However, the Na+/I- symporter (NIS), which mediates active iodide uptake into thyroid follicular cells, is also expressed in several non-thyroidal tissues.	Iodides	59-65	solute carrier family 5 member 5	Homo sapiens	13-29
14235320-2	1964	THE BINDING CONSTANTS OF IODIDE AND ACETATE IONS TO BOVINE SERUM ALBUMIN.	Iodides	25-31	albumin	Homo sapiens	59-72
13794411-1	1959	Influence of increasing concentrations of iodide on marking of insulin].	Iodides	42-48	insulin	Homo sapiens	63-70
33647627-0	2021	Iodide promotes bisphenol A (BPA) halogenation during chlorination: Evidence from 30 X-BPAs (X = Cl, Br, and I).	Iodides	0-6	chromosome 12 open reading frame 73	Homo sapiens	101-103
33882424-0	2021	Structure of a ternary complex of lactoperoxidase with iodide and hydrogen peroxide at 1.77 A resolution.	Iodides	55-61	lactoperoxidase	Homo sapiens	34-49
33882424-1	2021	Lactoperoxidase (LPO) is a mammalian heme peroxidase which catalyzes the conversion of thiocyanate (SCN ) and iodide (I-) by hydrogen peroxide (H2O2) into antimicrobial hypothiocyanite (OSCN ) and hypoiodite (IO-).	Iodides	110-116	lactoperoxidase	Homo sapiens	0-15
33882424-1	2021	Lactoperoxidase (LPO) is a mammalian heme peroxidase which catalyzes the conversion of thiocyanate (SCN ) and iodide (I-) by hydrogen peroxide (H2O2) into antimicrobial hypothiocyanite (OSCN ) and hypoiodite (IO-).	Iodides	110-116	lactoperoxidase	Homo sapiens	17-20
33882424-4	2021	We report here the first structure of the ternary complex of LPO with iodide (I-) and H2O2 at 1.77 A resolution.	Iodides	70-76	lactoperoxidase	Homo sapiens	61-64
5933527-0	1966	Effect of phospholipase A, C, and D on the iodide-complexing phospholipid of thyroid.	Iodides	43-49	phospholipase A and acyltransferase 1	Homo sapiens	10-25
13947229-0	1963	Vitamin B12 and thyrotoxicosis: the administration of vitamin B12 to patients with hyperthyroidism, and the in vitro oxidation of iodide by vitamin B12.	Iodides	130-136	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
33974556-2	2021	However, the Na+/I- symporter (NIS), which mediates active iodide uptake into thyroid follicular cells, is also expressed in several non-thyroidal tissues.	Iodides	59-65	solute carrier family 5 member 5	Homo sapiens	31-34
33651594-1	2021	We report the synthesis of colloidal EuS, La2S3, and LaS2 nanocrystals between 150 and 255  C using rare-earth iodides in oleylamine.	Iodides	111-118	chromosome 18 open reading frame 54	Homo sapiens	53-57
33912899-1	2021	CONTEXT: Iodide transport defect (ITD) (Online Mendelian Inheritance in Man #274400) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient iodide accumulation in thyroid follicular cells.	Iodides	9-15	solute carrier family 5 member 5	Homo sapiens	191-197
33912899-1	2021	CONTEXT: Iodide transport defect (ITD) (Online Mendelian Inheritance in Man #274400) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient iodide accumulation in thyroid follicular cells.	Iodides	229-235	solute carrier family 5 member 5	Homo sapiens	191-197
33912899-8	2021	Biochemical analyses revealed that G561E impairs the recognition of an adjacent tryptophan-acidic motif by the kinesin-1 subunit kinesin light chain 2 (KLC2), interfering with NIS maturation beyond the endoplasmic reticulum, and reducing iodide accumulation.	Iodides	238-244	kinesin light chain 2	Homo sapiens	129-150
33912899-8	2021	Biochemical analyses revealed that G561E impairs the recognition of an adjacent tryptophan-acidic motif by the kinesin-1 subunit kinesin light chain 2 (KLC2), interfering with NIS maturation beyond the endoplasmic reticulum, and reducing iodide accumulation.	Iodides	238-244	kinesin light chain 2	Homo sapiens	152-156
33912899-10	2021	Consistently, knockdown of Klc2 causes defective NIS maturation and consequently decreases iodide accumulation in rat thyroid cells.	Iodides	91-97	kinesin light chain 2	Rattus norvegicus	27-31
32791891-16	2021	Pendrin may be more important than NIS in the mediation of placental iodide transport.	Iodides	69-75	solute carrier family 26 member 4	Rattus norvegicus	0-7
33595298-1	2021	This work describes crystalline phases of the system [HSC(NH2)2]I/(CH3NH3)I/PbI2 and discusses the crystal structures in the context of a common cubic closest packing of organic cations and iodide anions with Pb2+ in all anionic octahedral voids.	Iodides	190-196	fucosyltransferase 1 (H blood group)	Homo sapiens	54-57
32791891-16	2021	Pendrin may be more important than NIS in the mediation of placental iodide transport.	Iodides	69-75	solute carrier family 5 member 5	Rattus norvegicus	35-38
33668649-3	2021	The human sodium/iodide symporter (NIS) and the sodium/glucose transporter (SGLT1) are involved in diseases such as iodide transport defect or glucose-galactose malabsorption.	Iodides	17-23	solute carrier family 5 member 1	Homo sapiens	76-81
33352258-0	2021	In vitro screening for chemical inhibition of the iodide recycling enzyme, iodotyrosine deiodinase.	Iodides	50-56	iodotyrosine deiodinase	Homo sapiens	75-98
33352258-1	2021	The iodide recycling enzyme, iodotyrosine deiodinase (IYD), is a largely unstudied molecular mechanism through which environmental chemicals can potentially cause thyroid disruption.	Iodides	4-10	iodotyrosine deiodinase	Homo sapiens	29-52
33352258-1	2021	The iodide recycling enzyme, iodotyrosine deiodinase (IYD), is a largely unstudied molecular mechanism through which environmental chemicals can potentially cause thyroid disruption.	Iodides	4-10	iodotyrosine deiodinase	Homo sapiens	54-57
33055303-1	2020	Objective: Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)).	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	173-179
33489878-0	2020	Downregulation of miR-146b-3p Inhibits Proliferation and Migration and Modulates the Expression and Location of Sodium/Iodide Symporter in Dedifferentiated Thyroid Cancer by Potentially Targeting MUC20.	Iodides	119-125	mucin 20, cell surface associated	Homo sapiens	196-201
31770751-1	2021	INTRODUCTION: A few reports stating that differences in the various types of contrast media injected into the pancreatic duct are related to the onset of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) have been published, and it was indicated that iodixanol which is a nonionic iodide radiographic contrast medium with a dimeric (2 dimers) structure may reduce the incidence of PEP.	Iodides	309-315	progestagen associated endometrial protein	Homo sapiens	227-230
33002449-2	2021	The sodium iodide symporter (NIS) transports iodide across mammalian intestinal and thyroid epithelia to deliver iodide for thyroid hormone production.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
33002449-2	2021	The sodium iodide symporter (NIS) transports iodide across mammalian intestinal and thyroid epithelia to deliver iodide for thyroid hormone production.	Iodides	45-51	solute carrier family 5 member 5	Homo sapiens	29-32
33291224-8	2020	These species D Ad vectors also successfully expressed the hNIS gene during infection leading to increased iodide uptake in multiple cancer cell lines.	Iodides	107-113	solute carrier family 5 member 5	Homo sapiens	59-63
33055303-1	2020	Objective: Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)).	Iodides	11-17	solute carrier family 26 member 4	Homo sapiens	213-220
33055303-1	2020	Objective: Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)).	Iodides	11-17	solute carrier family 26 member 4	Homo sapiens	227-234
32961913-1	2020	BACKGROUND: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is essential for the iodination of thyroglobulin (Tg) during thyroid hormone synthesis.	Iodides	118-124	thyroglobulin	Mus musculus	160-173
33085474-2	2020	Herein, the Ag NPs modified with aluminum and iodide ions (Ag IANPs) were introduced for Raman detection of proteins, including acidic BSA (PI 4.7), catalase (PI 5.4), beta-casein (PI 4.5), alpha-casein (PI 4.0), insulin (PI 5.35), basic myoglobin (PI 6.99), and lysozyme (PI 11.2).	Iodides	46-52	casein beta	Homo sapiens	168-179
32961913-6	2020	We, thus, hypothesized that Nrf2 might be involved in the transcriptional response to iodide overload.	Iodides	86-92	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-32
32961913-10	2020	RESULTS: Analysis of differentially expressed messenger RNAs (mRNAs) indicated that iodide overload upregulates inflammatory-, immune-, fibrosis- and oxidative stress-related pathways, including the Nrf2 pathway.	Iodides	84-90	nuclear factor, erythroid derived 2, like 2	Mus musculus	199-203
32961913-11	2020	Nrf2 KO mice showed a more pronounced inflammatory-autoimmune transcriptional response to iodide than WT mice.	Iodides	90-96	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
32961913-14	2020	CONCLUSIONS: Iodide overload induces the Nrf2 cytoprotective response and upregulates inflammatory, immune, and fibrosis pathways similar to autoimmune hyperthyroidism (Graves" disease) and PTC.	Iodides	13-19	nuclear factor, erythroid derived 2, like 2	Mus musculus	41-45
32333082-7	2020	Consistent with the marked differences in systemic exposure, systemic anti-CTLA-4 stimulated the onset of autoimmune thyroiditis in iodide-exposed NOD.H-2h4 mice, as measured by anti-thyroglobulin antibody titer, while hydrogel-encapsulated anti-CTLA-4 had a minimal effect (p <= 0.01).	Iodides	132-138	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	75-81
32826330-6	2020	To elucidate the mechanism underlying this phenomenon, we used a drug-free mouse model of hypothyroidism: mice lacking the sodium/iodide symporter (NIS), the plasma membrane protein that mediates active iodide uptake in the thyroid.	Iodides	130-136	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	148-151
32333082-7	2020	Consistent with the marked differences in systemic exposure, systemic anti-CTLA-4 stimulated the onset of autoimmune thyroiditis in iodide-exposed NOD.H-2h4 mice, as measured by anti-thyroglobulin antibody titer, while hydrogel-encapsulated anti-CTLA-4 had a minimal effect (p <= 0.01).	Iodides	132-138	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	246-252
32207625-2	2020	Nonradioactive isocyanates and sp3 or sp2 organozinc iodides generated amides in yields of 13%-87%.	Iodides	53-60	Sp2 transcription factor	Homo sapiens	38-41
32574822-3	2020	As a consequence, bromide and iodide also played important roles in DBP formation.	Iodides	30-36	D-box binding PAR bZIP transcription factor	Homo sapiens	68-71
32574822-4	2020	The DBP yields in HA-containing water during UV/chlorination decreased in the order of iodide loaded > freshwater >> bromide loaded, whereas DBP formation in AOM-containing water decreased remarkably with halides added (freshwater > bromide loaded >> iodide loaded) at high UV fluence.	Iodides	87-93	D-box binding PAR bZIP transcription factor	Homo sapiens	4-7
32532820-4	2020	Conversely, PTC cells in which MED16 had been further knocked down (MED16KD) exhibited enhanced cell migration, epithelial-mesenchymal transition (EMT), and RAI resistance, accompanied by decreased sodium/iodide symporter (NIS) levels.	Iodides	205-211	mediator complex subunit 16	Homo sapiens	31-36
32574822-7	2020	Therefore, UV/chlorine treatment may achieve good quality water with reduced DBP-associated toxicity in freshwater or iodide-containing water (iodide only), but careful consideration is needed when purifying source waters containing bromide (bromide only), especially for AOM/bromide-containing water.	Iodides	143-149	D-box binding PAR bZIP transcription factor	Homo sapiens	77-80
32162904-3	2020	Unique properties of eaq- and its generation in different ARP systems, particularly UV/sulfite and UV/iodide, are overviewed.	Iodides	102-108	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	58-61
32026684-1	2020	Iodide homeostasis and thyroid hormone metabolism in the brain are potentially related to changes in activity of the sodium iodide symporter (NIS).	Iodides	0-6	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	117-140
31967119-8	2020	Together with the complexation results by titration, the crystal structures of an endocyclic mercury(ii) perchlorate complex and an exocyclic mercury(ii) iodide complex revealed that the anion-controlled mercury(ii) sensing by L2 arises from the endo- and exo-coordination modes depending on the anion coordinating ability, which induces either metal-receptor/fluorophore binding (Hg-Ntert and Hg-Nfl) or no binding.	Iodides	154-160	neurofilament light chain	Homo sapiens	397-400
32049985-11	2020	Additionally, TNF-alpha and PMA were shown to have a negative impact on TSH-induced iodide uptake, consistent with the observed transcriptional downregulation of NIS.	Iodides	84-90	tumor necrosis factor	Homo sapiens	14-23
31972945-4	2020	Among the three Mg/Al ratios, the calcined Fe3O4@4:1 Mg/Al LDH exhibited excellent performance for iodide removal with 105.04 mg/g of the maximum iodide adsorption capacity due to its wide interlayer spacing and largest BET surface area.	Iodides	99-105	delta/notch like EGF repeat containing	Homo sapiens	220-223
32084174-1	2020	The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroid hormone production.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
32049985-1	2020	The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
32049985-4	2020	Defective NIS expression is the main reason for impaired iodide uptake in TC and NIS downregulation has been associated with several pathways linked to malignant transformation.	Iodides	57-63	solute carrier family 5 member 5	Homo sapiens	10-13
32049985-11	2020	Additionally, TNF-alpha and PMA were shown to have a negative impact on TSH-induced iodide uptake, consistent with the observed transcriptional downregulation of NIS.	Iodides	84-90	solute carrier family 5 member 5	Homo sapiens	162-165
32049985-13	2020	A better understanding of the mechanisms underlying NIS expression in the context of normal thyroid physiology may guide the development of pharmacological strategies to increase the efficiency of iodide uptake.	Iodides	197-203	solute carrier family 5 member 5	Homo sapiens	52-55
31971949-2	2020	Previous studies revealed that Solute Carrier Family 26 Member 4 (SLC26A4) being an essential gene of the multi-faceted transporter family SLC26 facilitates reflexive movement of Iodide into follicular lumen through apical membrane of thyrocyte.	Iodides	179-185	solute carrier family 26 member 4	Homo sapiens	31-64
31375570-11	2020	Conclusion: BRAF V600E alone and, particularly, coexisting BRAF V600E and TERT promoter mutations are strongly associated with loss of RAI avidity and impairment of the iodide-metabolizing machinery in recurrent PTC, showing a robust predictive value for failure of RAI treatment of PTC.	Iodides	169-175	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	12-16
31375570-11	2020	Conclusion: BRAF V600E alone and, particularly, coexisting BRAF V600E and TERT promoter mutations are strongly associated with loss of RAI avidity and impairment of the iodide-metabolizing machinery in recurrent PTC, showing a robust predictive value for failure of RAI treatment of PTC.	Iodides	169-175	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	59-63
31375570-11	2020	Conclusion: BRAF V600E alone and, particularly, coexisting BRAF V600E and TERT promoter mutations are strongly associated with loss of RAI avidity and impairment of the iodide-metabolizing machinery in recurrent PTC, showing a robust predictive value for failure of RAI treatment of PTC.	Iodides	169-175	telomerase reverse transcriptase	Homo sapiens	74-78
31938796-1	2020	The Pd(0)-catalyzed tandem intermolecular syn-carbopalladation/asymmetric C-H alkenylation reaction of N-ferrocenyl propiolamides with aryl iodides has been realized, generating planar chiral ferrocene[1,2-d] pyrrolinones in good yields.	Iodides	135-147	synemin	Homo sapiens	42-45
31971949-2	2020	Previous studies revealed that Solute Carrier Family 26 Member 4 (SLC26A4) being an essential gene of the multi-faceted transporter family SLC26 facilitates reflexive movement of Iodide into follicular lumen through apical membrane of thyrocyte.	Iodides	179-185	solute carrier family 26 member 4	Homo sapiens	66-73
31971949-3	2020	SLC26A4 gene encodes Pendred protein, a membrane glycoprotein, highly hydrophobic in nature, present at the apical membrane of thyrocyte functioning as transporter of iodide for thyroid cells.	Iodides	167-173	solute carrier family 26 member 4	Homo sapiens	0-7
31661251-5	2019	Quantum chemical calculations of suited Born-Haber cycles showed that these complexes are indeed stable, for Mg2+ and Ca2+ even with iodide employed as the anion and for Sr2+ and Ba2+ in the presence of GaI3.	Iodides	133-139	mucin 7, secreted	Homo sapiens	109-112
31830177-1	2020	A new hybrid lead iodide material (HP1) having 4-vinylphenylene ammonium as the organic cation has been prepared.	Iodides	18-24	defensin alpha 1	Homo sapiens	35-38
31568923-0	2020	Iodide modulates protein damage induced by the inflammation-associated heme enzyme myeloperoxidase.	Iodides	0-6	myeloperoxidase	Homo sapiens	83-98
31807182-9	2019	Furthermore, PTEN-knockdown decreased the expression of specific thyroid proteins (thyroglobulin, TG; thyroid peroxidase, TPO; and sodium/iodide symporter, NIS) and inhibited the iodide uptake ability of thyroid cells by downregulating PAX8, suggesting that PTEN deficiency may impair the function of thyroid cells.	Iodides	138-144	phosphatase and tensin homolog	Homo sapiens	13-17
31807182-9	2019	Furthermore, PTEN-knockdown decreased the expression of specific thyroid proteins (thyroglobulin, TG; thyroid peroxidase, TPO; and sodium/iodide symporter, NIS) and inhibited the iodide uptake ability of thyroid cells by downregulating PAX8, suggesting that PTEN deficiency may impair the function of thyroid cells.	Iodides	179-185	phosphatase and tensin homolog	Homo sapiens	13-17
31450096-0	2019	PtCu nanoprobe-initiated cascade reaction modulated iodide-responsive sensing interface for improved electrochemical immunosensor of neuron-specific enolase.	Iodides	52-58	enolase 2	Homo sapiens	133-156
31723126-4	2019	Herein, we have developed a direct one-step, scalable synthetic method for iodide capped PbS (PbS-I) NC inks.	Iodides	75-81	translocator protein	Homo sapiens	89-92
31723126-4	2019	Herein, we have developed a direct one-step, scalable synthetic method for iodide capped PbS (PbS-I) NC inks.	Iodides	75-81	translocator protein	Homo sapiens	94-99
31553594-4	2019	The unwanted I-CBP formation involved the oxidation of iodide by ferric ions to generate various reactive iodine species, which further oxidize organic compounds.	Iodides	55-61	CREB binding protein	Homo sapiens	15-18
31450096-2	2019	In this work, based on PtCu nanoprobe-mediated and iodide-catalyzed cascade reaction, an improved electrochemical immunosensor was elaborately designed for neuron-specific enolase (NSE) detection.	Iodides	51-57	enolase 2	Homo sapiens	156-179
31450096-2	2019	In this work, based on PtCu nanoprobe-mediated and iodide-catalyzed cascade reaction, an improved electrochemical immunosensor was elaborately designed for neuron-specific enolase (NSE) detection.	Iodides	51-57	enolase 2	Homo sapiens	181-184
30280943-7	2019	The PLN (labelled with IR-780 iodide) prolonged significantly fluorescence duration time compared to the SLN and the prolongation was further enhanced by the PLN-MP formulation.	Iodides	30-36	phospholamban	Rattus norvegicus	4-7
31533238-7	2019	The sodium iodide symporter (NIS) is a plasma membrane glycoprotein, a member of solute carrier family 5A (SLC5A5), located on the basolateral surfaces of the thyroid follicular epithelial cells, which mediates active iodide transport into thyroid follicular cells.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	107-113
31141766-4	2019	Further it was found that the sensor is highly selective towards fluoride over other anions including chloride, bromide, iodide, nitrate, borate, perchlorate and can quantitatively detect fluoride at ppb level with a limit of detection of 0.02 mg/ L or 20 ppb.	Iodides	121-127	histatin 1	Homo sapiens	200-203
31556300-0	2019	Ligand-Enabled Gold-Catalyzed C(sp2)-N Cross-Coupling Reactions of Aryl Iodides with Amines.	Iodides	67-79	Sp2 transcription factor	Homo sapiens	30-35
30280943-7	2019	The PLN (labelled with IR-780 iodide) prolonged significantly fluorescence duration time compared to the SLN and the prolongation was further enhanced by the PLN-MP formulation.	Iodides	30-36	phospholamban	Rattus norvegicus	158-161
31339315-5	2019	In this article, the two new isostructural (TDMP)PbX4 chloride and iodide analogues could be synthesized and structurally characterized.	Iodides	67-73	PBX homeobox 4	Homo sapiens	49-53
30982513-4	2019	By taking advantage of the different vapor generation conditions for NO2-, NO3- and NH4+, a unit integrating with sampling, heating, cooling, gas-liquid separation and moisture removal is employed for controlling the vapor generation process, by reacting with either iodide or titanium (III).	Iodides	267-273	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
31413410-6	2019	The linear calibration curve of the developed method towards iodide was in the concentration range of 0.5-4.0 mg/L with sensitivity of - 1.383 microA mg/L-1 cm-2 (R2 = 0.9950), limit of detection (LOD) of 0.3 mg/L and limit of quantification (LOQ) of 1.0 mg/L, respectively.	Iodides	61-67	L1 cell adhesion molecule	Homo sapiens	153-161
31331356-14	2019	HMGB1-knockdown dramatically suppressed autophagy, NIS degradation and boosted iodide uptake in HBSS-treated cells.	Iodides	79-85	high mobility group box 1	Homo sapiens	0-5
31372509-2	2019	Pendrin, the iodide exporter that transports iodide to thyroid follicles, is responsible for Pendred syndrome, a disorder characterized by congenital hypothyroidism and hearing loss.	Iodides	13-19	solute carrier family 26 member 4	Homo sapiens	0-7
31372509-2	2019	Pendrin, the iodide exporter that transports iodide to thyroid follicles, is responsible for Pendred syndrome, a disorder characterized by congenital hypothyroidism and hearing loss.	Iodides	45-51	solute carrier family 26 member 4	Homo sapiens	0-7
31372509-5	2019	We observe that SLC26A7 is specifically expressed in normal thyroid tissues and demonstrate its function in iodide transport.	Iodides	108-114	solute carrier family 26 member 7	Homo sapiens	16-23
31372509-7	2019	The mutated SLC26A7 protein shows an abnormal cytoplasmic localisation and lacks the iodide transport function.	Iodides	85-91	solute carrier family 26 member 7	Homo sapiens	12-19
31788697-14	2019	In milk, 80-93% of the total iodine was inorganic iodide.	Iodides	50-56	Weaning weight-maternal milk	Bos taurus	3-7
31259546-4	2019	The weakening of the Pb-I bond following the hole trapping (oxidation of the iodide site) and its expulsion from the lattice in the form of iodine provided further insight into the photoinduced segregation of halide ions in mixed halide perovskite films.	Iodides	77-83	apolipoprotein B mRNA editing enzyme catalytic subunit 3C	Homo sapiens	21-25
31788697-15	2019	CONCLUSION: Nearly all of the iodine in cow milk is iodide and although fractional iodine absorption from milk decreases with increasing dose, its bioavailability is high.	Iodides	52-58	Weaning weight-maternal milk	Bos taurus	44-48
31269588-1	2019	Objective: To confirm whether beta-catenin nuclear translocation in thyroid cancer stem cells can differentiate into thyroid cancer cells without functional membrane expression of sodium-iodine transporter (NIS) and be resistant to iodide 131 treatment.	Iodides	232-238	catenin beta 1	Homo sapiens	30-42
31115276-2	2019	ITD is an uncommon cause of dyshormonogenetic congenital hypothyroidism that results from inactivating mutations in the sodium/iodide symporter (NIS)-coding SLC5A5 gene.	Iodides	127-133	solute carrier family 5 member 5	Homo sapiens	157-163
30969810-2	2019	Here, we compare the impact of the most common CF mutation F508del on the function of human and mouse CFTR heterologously expressed in mammalian cells and their response to CFTR modulators using the iodide efflux and patch-clamp techniques.	Iodides	199-205	CF transmembrane conductance regulator	Homo sapiens	173-177
30969810-5	2019	However, they all produced CFTR-mediated iodide efflux with human F508del-CFTR-expressing CHO cells, while fifteen CFTR correctors rescued the plasma membrane expression of both human and mouse F508del-CFTR.	Iodides	41-47	CF transmembrane conductance regulator	Homo sapiens	27-31
30969810-5	2019	However, they all produced CFTR-mediated iodide efflux with human F508del-CFTR-expressing CHO cells, while fifteen CFTR correctors rescued the plasma membrane expression of both human and mouse F508del-CFTR.	Iodides	41-47	CF transmembrane conductance regulator	Homo sapiens	74-78
30969810-5	2019	However, they all produced CFTR-mediated iodide efflux with human F508del-CFTR-expressing CHO cells, while fifteen CFTR correctors rescued the plasma membrane expression of both human and mouse F508del-CFTR.	Iodides	41-47	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	74-78
30969810-5	2019	However, they all produced CFTR-mediated iodide efflux with human F508del-CFTR-expressing CHO cells, while fifteen CFTR correctors rescued the plasma membrane expression of both human and mouse F508del-CFTR.	Iodides	41-47	cystic fibrosis transmembrane conductance regulator	Mus musculus	74-78
30969810-6	2019	Interestingly, the CFTR potentiator genistein enhanced CFTR-mediated iodide efflux from CHO cells expressing either human or mouse F508del-CFTR, whereas it only potentiated human F508del-CFTR Cl- channels in cell-free membrane patches, suggesting that its action on mouse F508del-CFTR is indirect.	Iodides	69-75	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	19-23
30969810-6	2019	Interestingly, the CFTR potentiator genistein enhanced CFTR-mediated iodide efflux from CHO cells expressing either human or mouse F508del-CFTR, whereas it only potentiated human F508del-CFTR Cl- channels in cell-free membrane patches, suggesting that its action on mouse F508del-CFTR is indirect.	Iodides	69-75	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	55-59
30969810-6	2019	Interestingly, the CFTR potentiator genistein enhanced CFTR-mediated iodide efflux from CHO cells expressing either human or mouse F508del-CFTR, whereas it only potentiated human F508del-CFTR Cl- channels in cell-free membrane patches, suggesting that its action on mouse F508del-CFTR is indirect.	Iodides	69-75	cystic fibrosis transmembrane conductance regulator	Mus musculus	55-59
30969810-6	2019	Interestingly, the CFTR potentiator genistein enhanced CFTR-mediated iodide efflux from CHO cells expressing either human or mouse F508del-CFTR, whereas it only potentiated human F508del-CFTR Cl- channels in cell-free membrane patches, suggesting that its action on mouse F508del-CFTR is indirect.	Iodides	69-75	CF transmembrane conductance regulator	Homo sapiens	55-59
30969810-6	2019	Interestingly, the CFTR potentiator genistein enhanced CFTR-mediated iodide efflux from CHO cells expressing either human or mouse F508del-CFTR, whereas it only potentiated human F508del-CFTR Cl- channels in cell-free membrane patches, suggesting that its action on mouse F508del-CFTR is indirect.	Iodides	69-75	cystic fibrosis transmembrane conductance regulator	Mus musculus	55-59
30657598-9	2019	Ascorbic acid and iodide were separated within 45 s with peak resolution of 1.2 and sensitivities of 198 and 492 pA/muM, respectively.	Iodides	18-24	latexin	Homo sapiens	116-119
30904818-11	2019	Besides, over-expression of miR-206 could notably promoted the expression of NIS, an intrinsic membrane protein that mediates the active transport of iodide into the thyroid and other tissues, playing a critical role in the progress.	Iodides	150-156	microRNA 206	Homo sapiens	28-35
31333278-3	2019	Specifically, the chloride and bromide derivatives, [H(sebenzimMe)]2ZnX2 and [H(sebenzimMe)]2CdX2 (X = Cl, Br), exhibit two intramolecular N-H   X interactions, whereas the iodide derivatives, [H(sebenzimMe)]2ZnI2 and [H(sebenzimMe)]2CdI2, exhibit only one intramolecular N-H   I interaction.	Iodides	173-179	caudal type homeobox 2	Homo sapiens	93-97
30978008-3	2019	The aluminum diphenyl derivative was successfully converted to the iodide complex (formazanate)AlI2, and a comparison of spectroscopic/structural data for these new complexes is provided.	Iodides	67-73	adhesion molecule with Ig like domain 1	Homo sapiens	95-99
30191346-1	2019	BACKGROUND: Recent studies have described important roles for the sodium iodide symporter (NIS) in tumor behavior.	Iodides	73-79	solute carrier family 5 member 5	Homo sapiens	91-94
30615234-14	2019	Lower rates of Cl- and I- absorption in the DRA knockout intestine suggest that DRA might have a previously unrecognized role in iodide uptake.	Iodides	129-135	solute carrier family 26, member 3	Mus musculus	44-47
30851455-0	2019	Matrix metallopeptidase 2 targeted delivery of gold nanostars decorated with IR-780 iodide for dual-modal imaging and enhanced photothermal/photodynamic therapy.	Iodides	84-90	matrix metallopeptidase 2	Homo sapiens	0-25
30256977-2	2019	OBJECTIVES: To investigate the utility and molecular underpinnings of enhancing lesional iodide uptake with the BRAF inhibitor vemurafenib in patients with RAI-refractory (RAIR).	Iodides	89-95	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	112-116
30934973-4	2019	The calibration graph for iodide was linear in the range of 0.5-10.0 mg L-1 with a correlation coefficient of 0.9996.	Iodides	26-32	L1 cell adhesion molecule	Mus musculus	72-75
30934973-8	2019	The iodide concentrations in the mineral water samples ranged from 0.58 to 2.88 mg L-1.	Iodides	4-10	L1 cell adhesion molecule	Mus musculus	83-86
30616062-11	2019	The amount of AOX also increased with the increase in iodide concentration.	Iodides	54-60	acyl-CoA oxidase 1	Homo sapiens	14-17
30615234-14	2019	Lower rates of Cl- and I- absorption in the DRA knockout intestine suggest that DRA might have a previously unrecognized role in iodide uptake.	Iodides	129-135	solute carrier family 26, member 3	Mus musculus	80-83
30615234-15	2019	This study validates that 125 I- traces transepithelial Cl- fluxes across the mouse large intestine, provides insights into the mechanism of net Cl- secretion and suggests that DRA might be involved in intestinal iodide absorption.	Iodides	213-219	solute carrier family 26, member 3	Mus musculus	177-180
30691130-4	2019	The X-ray structures of the adducts of RNase A and HEWL with [Pt(I)(Me)(dmphen)(olefin)] are not of very high quality, but overall data indicate that, upon reaction with RNase A, the compound coordinates the side chain of His105 upon releasing the iodide ligand, but retains the pentacoordination.	Iodides	248-254	ribonuclease pancreatic	Bos taurus	39-46
30744098-1	2019	Pendrin (SLC26A4), a Cl-/anion exchanger, is expressed at high levels in kidney, thyroid, and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride reabsorption, iodide accumulation, and endolymph ion balance, respectively.	Iodides	194-200	solute carrier family 26 member 4	Homo sapiens	0-7
30744098-1	2019	Pendrin (SLC26A4), a Cl-/anion exchanger, is expressed at high levels in kidney, thyroid, and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride reabsorption, iodide accumulation, and endolymph ion balance, respectively.	Iodides	194-200	solute carrier family 26 member 4	Homo sapiens	9-16
30774121-5	2019	When iodide is added to a mixed culture of the two cell types, they enter the donor cells via the SLC26A4 transporter and diffuse to the adjacent acceptor cells via GJs where they quench the YFP fluorescence.	Iodides	5-11	solute carrier family 26 member 4	Homo sapiens	98-105
30691130-4	2019	The X-ray structures of the adducts of RNase A and HEWL with [Pt(I)(Me)(dmphen)(olefin)] are not of very high quality, but overall data indicate that, upon reaction with RNase A, the compound coordinates the side chain of His105 upon releasing the iodide ligand, but retains the pentacoordination.	Iodides	248-254	ribonuclease pancreatic	Bos taurus	170-177
28990511-5	2019	RESULTS: In vitro studies showed that sunitinib targeted the cytosolic MEK/ERK and SAPK/JNK pathways in the RET/PTC1 cell inhibiting cell proliferation and causing stimulation of sodium/iodide symporter (NIS) gene expression in RET/PTC1 cells.	Iodides	186-192	ret proto-oncogene	Homo sapiens	108-111
30641980-9	2019	In the CFTR vector transduced cells, we were able to detect CFTR mRNA expression using qPCR and function correction using fluorometric image plate reader (FLIPR) and iodide efflux assays.	Iodides	166-172	CF transmembrane conductance regulator	Homo sapiens	7-11
28990511-5	2019	RESULTS: In vitro studies showed that sunitinib targeted the cytosolic MEK/ERK and SAPK/JNK pathways in the RET/PTC1 cell inhibiting cell proliferation and causing stimulation of sodium/iodide symporter (NIS) gene expression in RET/PTC1 cells.	Iodides	186-192	patched 1	Homo sapiens	112-116
30199802-2	2018	Adsorbable organic halogen (AOX) is a parameter conventionally used to indicate the sum of organic halogenated disinfection byproducts (DBPs), which are formed from the reactions of disinfectants with dissolved organic matter, bromide and iodide in water.	Iodides	239-245	acyl-CoA oxidase 1	Homo sapiens	28-31
30121623-6	2019	Radioiodide uptake assays revealed a 4.9-fold increase in NIS-mediated perchlorate-sensitive iodide uptake in SMAD-NIS-MSCs after TGFB1 stimulation compared to unstimulated cells demonstrating the successful establishment of MSCs, which induce NIS expression in response to activation of TGFB1 signaling using a SMAD-responsive promoter.	Iodides	5-11	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	58-61
30121623-6	2019	Radioiodide uptake assays revealed a 4.9-fold increase in NIS-mediated perchlorate-sensitive iodide uptake in SMAD-NIS-MSCs after TGFB1 stimulation compared to unstimulated cells demonstrating the successful establishment of MSCs, which induce NIS expression in response to activation of TGFB1 signaling using a SMAD-responsive promoter.	Iodides	5-11	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	115-118
30121623-6	2019	Radioiodide uptake assays revealed a 4.9-fold increase in NIS-mediated perchlorate-sensitive iodide uptake in SMAD-NIS-MSCs after TGFB1 stimulation compared to unstimulated cells demonstrating the successful establishment of MSCs, which induce NIS expression in response to activation of TGFB1 signaling using a SMAD-responsive promoter.	Iodides	5-11	transforming growth factor, beta 1	Mus musculus	130-135
30121623-6	2019	Radioiodide uptake assays revealed a 4.9-fold increase in NIS-mediated perchlorate-sensitive iodide uptake in SMAD-NIS-MSCs after TGFB1 stimulation compared to unstimulated cells demonstrating the successful establishment of MSCs, which induce NIS expression in response to activation of TGFB1 signaling using a SMAD-responsive promoter.	Iodides	5-11	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	115-118
30137636-1	2018	The enzyme iodotyrosine deiodinase (dehalogenase, IYD) catalyzes iodide recycling and promotes iodide retention in thyroid follicular cells.	Iodides	65-71	iodotyrosine deiodinase L homeolog	Xenopus laevis	50-53
30137636-2	2018	Loss of function or chemical inhibition of IYD reduces available iodide for thyroid hormone synthesis, which leads to hormone insufficiency in tissues and subsequent negative developmental consequences.	Iodides	65-71	iodotyrosine deiodinase L homeolog	Xenopus laevis	43-46
30595693-4	2018	Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80-90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells.	Iodides	206-212	solute carrier family 5 member 5	Homo sapiens	41-44
30595693-4	2018	Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80-90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells.	Iodides	206-212	solute carrier family 5 member 5	Homo sapiens	45-51
30595693-4	2018	Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80-90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells.	Iodides	206-212	solute carrier family 5 member 5	Homo sapiens	53-85
30166349-0	2018	WDR-23 and SKN-1/Nrf2 Coordinate with the BLI-3 Dual Oxidase in Response to Iodide-Triggered Oxidative Stress.	Iodides	76-82	DDB1- and CUL4-associated factor 11 homolog	Caenorhabditis elegans	0-6
30095189-1	2018	The direct synthesis of organocalcium compounds (heavy Grignard reagents) by the reduction of organyl halides with activated calcium powder succeeded in a straightforward manner for organic bromides and iodides that are bound at sp2 -hybridized carbon atoms.	Iodides	203-210	Sp2 transcription factor	Homo sapiens	229-232
30166349-0	2018	WDR-23 and SKN-1/Nrf2 Coordinate with the BLI-3 Dual Oxidase in Response to Iodide-Triggered Oxidative Stress.	Iodides	76-82	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	11-16
30166349-0	2018	WDR-23 and SKN-1/Nrf2 Coordinate with the BLI-3 Dual Oxidase in Response to Iodide-Triggered Oxidative Stress.	Iodides	76-82	Dual oxidase 1	Caenorhabditis elegans	42-47
30166349-4	2018	We previously found that the oxidative stress induced by excess iodide can be relieved by loss of function in the BLI-3/TSP-15/DOXA-1 dual oxidase complex.	Iodides	64-70	Dual oxidase 1	Caenorhabditis elegans	114-119
30166349-4	2018	We previously found that the oxidative stress induced by excess iodide can be relieved by loss of function in the BLI-3/TSP-15/DOXA-1 dual oxidase complex.	Iodides	64-70	Tetraspanin-15	Caenorhabditis elegans	120-126
30166349-4	2018	We previously found that the oxidative stress induced by excess iodide can be relieved by loss of function in the BLI-3/TSP-15/DOXA-1 dual oxidase complex.	Iodides	64-70	Dual oxidase maturation factor 1	Caenorhabditis elegans	127-133
30166349-6	2018	wdr-23(lf) can interact with bli-3 mutations in a manner different from skn-1(gf) Transcriptome studies suggest that excess iodide causes developmental arrest largely independent of changes in gene expression, and wdr-23(lf) could affect the expression of a subset of genes by a mechanism different from SKN-1 activation.	Iodides	124-130	DDB1- and CUL4-associated factor 11 homolog	Caenorhabditis elegans	0-6
30166349-6	2018	wdr-23(lf) can interact with bli-3 mutations in a manner different from skn-1(gf) Transcriptome studies suggest that excess iodide causes developmental arrest largely independent of changes in gene expression, and wdr-23(lf) could affect the expression of a subset of genes by a mechanism different from SKN-1 activation.	Iodides	124-130	Dual oxidase 1	Caenorhabditis elegans	29-34
30166349-6	2018	wdr-23(lf) can interact with bli-3 mutations in a manner different from skn-1(gf) Transcriptome studies suggest that excess iodide causes developmental arrest largely independent of changes in gene expression, and wdr-23(lf) could affect the expression of a subset of genes by a mechanism different from SKN-1 activation.	Iodides	124-130	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	304-309
30166349-7	2018	We propose that WDR-23 and SKN-1 coordinate with the BLI-3/TSP-15/DOXA-1 dual oxidase complex in response to iodide-triggered oxidative stress.	Iodides	109-115	DDB1- and CUL4-associated factor 11 homolog	Caenorhabditis elegans	16-22
30166349-7	2018	We propose that WDR-23 and SKN-1 coordinate with the BLI-3/TSP-15/DOXA-1 dual oxidase complex in response to iodide-triggered oxidative stress.	Iodides	109-115	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	27-32
30166349-7	2018	We propose that WDR-23 and SKN-1 coordinate with the BLI-3/TSP-15/DOXA-1 dual oxidase complex in response to iodide-triggered oxidative stress.	Iodides	109-115	Dual oxidase 1	Caenorhabditis elegans	53-58
30166349-7	2018	We propose that WDR-23 and SKN-1 coordinate with the BLI-3/TSP-15/DOXA-1 dual oxidase complex in response to iodide-triggered oxidative stress.	Iodides	109-115	Tetraspanin-15	Caenorhabditis elegans	59-65
30166349-7	2018	We propose that WDR-23 and SKN-1 coordinate with the BLI-3/TSP-15/DOXA-1 dual oxidase complex in response to iodide-triggered oxidative stress.	Iodides	109-115	Dual oxidase maturation factor 1	Caenorhabditis elegans	66-72
30333321-4	2018	SLC26A7 is a member of the same transporter family as SLC26A4 (pendrin), an anion exchanger with affinity for iodide and chloride (among others), whose gene mutations cause congenital deafness and dyshormonogenic goiter.	Iodides	110-116	solute carrier family 26, member 7	Mus musculus	0-7
30217930-1	2018	The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
30217930-1	2018	The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	137-140
30333321-4	2018	SLC26A7 is a member of the same transporter family as SLC26A4 (pendrin), an anion exchanger with affinity for iodide and chloride (among others), whose gene mutations cause congenital deafness and dyshormonogenic goiter.	Iodides	110-116	solute carrier family 26, member 4	Mus musculus	54-61
30333321-4	2018	SLC26A7 is a member of the same transporter family as SLC26A4 (pendrin), an anion exchanger with affinity for iodide and chloride (among others), whose gene mutations cause congenital deafness and dyshormonogenic goiter.	Iodides	110-116	solute carrier family 26, member 4	Mus musculus	63-70
30337961-3	2018	Use of BRAF V600E inhibitors could partly restore NIS expression and Iodide uptake by inhibition of mitogen-activated protein kinase (MAPK) pathway.	Iodides	69-75	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	7-11
30337961-3	2018	Use of BRAF V600E inhibitors could partly restore NIS expression and Iodide uptake by inhibition of mitogen-activated protein kinase (MAPK) pathway.	Iodides	69-75	mitogen-activated protein kinase 3	Homo sapiens	134-138
30337961-11	2018	Conclusion: Simultaneously suppressing BRAF V600E and p-ERK restored NIS expression and increase Iodide uptake in PTC cells, which was associated the inhibition of p-ERK expression.	Iodides	97-103	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	39-43
30337961-11	2018	Conclusion: Simultaneously suppressing BRAF V600E and p-ERK restored NIS expression and increase Iodide uptake in PTC cells, which was associated the inhibition of p-ERK expression.	Iodides	97-103	mitogen-activated protein kinase 1	Homo sapiens	56-59
30337961-11	2018	Conclusion: Simultaneously suppressing BRAF V600E and p-ERK restored NIS expression and increase Iodide uptake in PTC cells, which was associated the inhibition of p-ERK expression.	Iodides	97-103	mitogen-activated protein kinase 1	Homo sapiens	166-169
29957358-1	2018	This paper evaluates the effect of various lyotropic anions (chloride, sulfate, perchlorate, iodide, nitrate, bromide) on the thermodynamic stability and dynamics of native cytochrome c (Cyt c) at pH 7.0.	Iodides	93-99	cytochrome c, somatic	Equus caballus	173-185
29777899-0	2018	Congenital dyshormonogenic hypothyroidism with goiter caused by a sodium/iodide symporter (SLC5A5) mutation in a family of Shih-Tzu dogs.	Iodides	73-79	solute carrier family 5 member 5	Canis lupus familiaris	91-97
29957358-1	2018	This paper evaluates the effect of various lyotropic anions (chloride, sulfate, perchlorate, iodide, nitrate, bromide) on the thermodynamic stability and dynamics of native cytochrome c (Cyt c) at pH 7.0.	Iodides	93-99	cytochrome c, somatic	Equus caballus	187-192
29923297-3	2018	The results showed that excessive iodide could decrease cell viability, reduce glutathione (GSH) and superoxide dismutase (SOD), and increase the degree of autophagy (by changing the cellular ultrastructure and raising the autophagy-related mRNA and protein expression of LC3, Beclin1, and p62), which were correlated with the immunofluorescence labeling.	Iodides	34-40	superoxide dismutase 1	Homo sapiens	101-121
30116045-2	2018	Here, we developed a positron emission tomography (PET) technique based on the sodium-iodide symporter (NIS) gene fused with the carboxyl-terminal of ornithine decarboxylase (cODC) that noninvasively images cancer cells with inhibited proteasome activity.	Iodides	86-92	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	104-107
29779372-6	2018	The method was implemented using a 10 x 10 micropillar array (size = 3 x 3 mm) on CFTR-expressing epithelial cells, in which CFTR chloride channel function was measured from fluorescence in response to iodide addition using a genetically encoded cytoplasmic yellow fluorescent protein halide indicator.	Iodides	202-208	CF transmembrane conductance regulator	Homo sapiens	125-129
29797535-2	2018	The transformation introduces a cyanoalkyl group to the ortho position of ArI(OAc)2 and simultaneously reduces the aryl iodine(III) to iodide, thus providing alpha-(2-iodoaryl) nitrile as the product.	Iodides	135-141	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	74-83
29923297-3	2018	The results showed that excessive iodide could decrease cell viability, reduce glutathione (GSH) and superoxide dismutase (SOD), and increase the degree of autophagy (by changing the cellular ultrastructure and raising the autophagy-related mRNA and protein expression of LC3, Beclin1, and p62), which were correlated with the immunofluorescence labeling.	Iodides	34-40	superoxide dismutase 1	Homo sapiens	123-126
29923297-3	2018	The results showed that excessive iodide could decrease cell viability, reduce glutathione (GSH) and superoxide dismutase (SOD), and increase the degree of autophagy (by changing the cellular ultrastructure and raising the autophagy-related mRNA and protein expression of LC3, Beclin1, and p62), which were correlated with the immunofluorescence labeling.	Iodides	34-40	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	272-275
29923297-3	2018	The results showed that excessive iodide could decrease cell viability, reduce glutathione (GSH) and superoxide dismutase (SOD), and increase the degree of autophagy (by changing the cellular ultrastructure and raising the autophagy-related mRNA and protein expression of LC3, Beclin1, and p62), which were correlated with the immunofluorescence labeling.	Iodides	34-40	beclin 1	Homo sapiens	277-284
29923297-3	2018	The results showed that excessive iodide could decrease cell viability, reduce glutathione (GSH) and superoxide dismutase (SOD), and increase the degree of autophagy (by changing the cellular ultrastructure and raising the autophagy-related mRNA and protein expression of LC3, Beclin1, and p62), which were correlated with the immunofluorescence labeling.	Iodides	34-40	nucleoporin 62	Homo sapiens	290-293
29742982-10	2018	RESULTS: The study shows that Nrf2 mediates antioxidant transcriptional responses in thyroid cells and protects the thyroid from oxidation induced by iodide overload.	Iodides	150-156	NFE2 like bZIP transcription factor 2	Rattus norvegicus	30-34
29772533-1	2018	We observed local homology between human pendrin and sodium/iodide symporter (NIS), that was absent in the NIS-homologous sodium/monocarboxylate transporter or apical iodide transporter (AIT) which, however, does not transport iodide.	Iodides	60-66	solute carrier family 26 member 4	Homo sapiens	41-48
29742982-13	2018	Yet, despite upregulating Tg levels, Nrf2 limits Tg iodination both under basal conditions and in response to excess iodide.	Iodides	117-123	NFE2 like bZIP transcription factor 2	Rattus norvegicus	37-41
29742982-13	2018	Yet, despite upregulating Tg levels, Nrf2 limits Tg iodination both under basal conditions and in response to excess iodide.	Iodides	117-123	thyroglobulin	Rattus norvegicus	49-51
29742982-14	2018	CONCLUSIONS: Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide.	Iodides	108-114	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17
29742982-14	2018	CONCLUSIONS: Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide.	Iodides	225-231	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17
29631680-5	2018	Sodium Iodide Symporter (NIS) gene is a plasma membrane glycoprotein that mediates iodide uptake in thyroid glands, stomach, salivary glands, lactating mammary glands and intestine.	Iodides	83-89	solute carrier family 5 member 5	Homo sapiens	25-28
29716526-9	2018	Overexpression of NKX2.5 in PCCL3 cells led to: 1) downregulation of thyroid differentiation markers (thyrotropin receptor, thyroperoxidase and sodium-iodide symporter); 2) reduced iodide uptake; 3) increased extracellular H2O2 generation, dual oxidase 1 mRNA levels and activity of DuOx1 promoter.	Iodides	151-157	NK2 homeobox 5	Rattus norvegicus	18-24
29112772-1	2018	Na+ /I- symporter (NIS) transports iodide into thyrocytes, a fundamental step for thyroid hormone biosynthesis.	Iodides	35-41	solute carrier family 5 member 5	Rattus norvegicus	0-17
29228274-4	2018	To begin to address the potential for chemicals to inhibit these enzymes an adenovirus expression system was used to produce human deiodinase type 1 (DIO1) enzyme, established robust assay parameters for nonradioactive determination of iodide release by the Sandell-Kolthoff method, and employed a 96-well plate format for screening chemical libraries.	Iodides	236-242	iodothyronine deiodinase 1	Homo sapiens	131-148
29228274-4	2018	To begin to address the potential for chemicals to inhibit these enzymes an adenovirus expression system was used to produce human deiodinase type 1 (DIO1) enzyme, established robust assay parameters for nonradioactive determination of iodide release by the Sandell-Kolthoff method, and employed a 96-well plate format for screening chemical libraries.	Iodides	236-242	iodothyronine deiodinase 1	Homo sapiens	150-154
29242405-11	2018	Mechanistically, reactivation of functional hNIS expression could be attributed to activation of the transcription factors activating transcription factor 3 and protooncogene c-fosConclusion: DLCs could represent a promising adjunctive therapy for restoring iodide avidity within the full spectrum from RAI-refractory dedifferentiated to ATC.	Iodides	258-264	solute carrier family 5 member 5	Homo sapiens	44-48
29631680-6	2018	NIS gene transports iodide from the blood to the gastric epithelial cells.	Iodides	20-26	solute carrier family 5 member 5	Homo sapiens	0-3
29181619-12	2018	CONCLUSIONS: The results of our study suggest that miR-326 may target the Ets-1 protein to contribute to iodide-induced thyroiditis, providing a new theoretical basis for the use of miRNA targeting therapy for the treatment of autoimmune diseases.	Iodides	105-111	microRNA 326	Mus musculus	51-58
29094470-6	2018	Here, the inner filter effect is applied to detect the iodide ion and exhibited a wide linear response concentration range (10-60 muM) with a limit of detection (LOD) of 0.32 muM.	Iodides	55-61	latexin	Homo sapiens	130-133
29094470-6	2018	Here, the inner filter effect is applied to detect the iodide ion and exhibited a wide linear response concentration range (10-60 muM) with a limit of detection (LOD) of 0.32 muM.	Iodides	55-61	latexin	Homo sapiens	175-178
29467904-2	2018	Human sodium iodide symporter (hNIS) is a molecular target of certain tumors types.	Iodides	13-19	solute carrier family 5 member 5	Homo sapiens	31-35
29181619-12	2018	CONCLUSIONS: The results of our study suggest that miR-326 may target the Ets-1 protein to contribute to iodide-induced thyroiditis, providing a new theoretical basis for the use of miRNA targeting therapy for the treatment of autoimmune diseases.	Iodides	105-111	E26 avian leukemia oncogene 1, 5' domain	Mus musculus	74-79
29052370-5	2017	Compared with the post-modified polymers with iodide and hexafluorophosphate anions, IT-POP-1 possesses the highest surface area and the best CO2 uptake capacity with excellent adsorption selectivity over N2 .	Iodides	46-52	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	88-93
29377356-2	2018	OBJECTIVE: Determine whether BRD bacterial and viral pathogens are susceptible to the lactoperoxidase/hydrogen peroxide/iodide (LPO/H2 O2 /I- ) system in vitro and to determine whether the oral administration of sodium iodide (NaI) could achieve sufficient concentrations of iodine (I) in the respiratory secretions of weaned beef calves to inactivate these pathogens in vivo.	Iodides	120-126	lactoperoxidase	Bos taurus	128-131
29131623-1	2017	Several apical iodide translocation pathways have been proposed for iodide efflux out of thyroid follicular cells, including a pathway mediated by the sodium-coupled monocarboxylate transporter 1 (SMCT1), which remains controversial.	Iodides	15-21	solute carrier family 5 member 8	Homo sapiens	151-195
29131623-1	2017	Several apical iodide translocation pathways have been proposed for iodide efflux out of thyroid follicular cells, including a pathway mediated by the sodium-coupled monocarboxylate transporter 1 (SMCT1), which remains controversial.	Iodides	15-21	solute carrier family 5 member 8	Homo sapiens	197-202
29131623-1	2017	Several apical iodide translocation pathways have been proposed for iodide efflux out of thyroid follicular cells, including a pathway mediated by the sodium-coupled monocarboxylate transporter 1 (SMCT1), which remains controversial.	Iodides	68-74	solute carrier family 5 member 8	Homo sapiens	151-195
29131623-1	2017	Several apical iodide translocation pathways have been proposed for iodide efflux out of thyroid follicular cells, including a pathway mediated by the sodium-coupled monocarboxylate transporter 1 (SMCT1), which remains controversial.	Iodides	68-74	solute carrier family 5 member 8	Homo sapiens	197-202
29131623-2	2017	Herein, we evaluate structural and functional similarities between SMCT1 and the well-studied sodium-iodide symporter (NIS) that mediates the first step of iodide entry into the thyroid.	Iodides	101-107	solute carrier family 5 member 8	Homo sapiens	67-72
29131623-3	2017	Free-energy calculations using a force field with electronic polarizability verify the presence of a conserved iodide-binding pocket between the TM2, TM3, and TM7 segments in hNIS, where iodide is coordinated by Phe67, Gln72, Cys91, and Gln94.	Iodides	111-117	tropomyosin 3	Homo sapiens	150-153
29131623-3	2017	Free-energy calculations using a force field with electronic polarizability verify the presence of a conserved iodide-binding pocket between the TM2, TM3, and TM7 segments in hNIS, where iodide is coordinated by Phe67, Gln72, Cys91, and Gln94.	Iodides	187-193	tropomyosin 3	Homo sapiens	150-153
29131623-6	2017	Correspondingly, mutation of Thr91 to glycine in hSMCT1 makes the pocket structure more like that of wild-type hNIS, increasing its iodide affinity.	Iodides	132-138	solute carrier family 5 member 8	Homo sapiens	49-55
29131623-7	2017	These results suggest that wild-type hSMCT1 in the inward-facing conformation may bind iodide only very weakly, which may have implications for its ability to transport iodide.	Iodides	87-93	solute carrier family 5 member 8	Homo sapiens	37-43
29131623-7	2017	These results suggest that wild-type hSMCT1 in the inward-facing conformation may bind iodide only very weakly, which may have implications for its ability to transport iodide.	Iodides	169-175	solute carrier family 5 member 8	Homo sapiens	37-43
28153798-4	2017	The iodination of the tyrosyl residues of TG preceeds TH biosynthesis, which depends on the interaction of iodide, TG, hydrogen peroxide (H2O2) and thyroid peroxidase (TPO) at the apical plasma membrane of thyrocytes.	Iodides	107-113	thyroglobulin	Homo sapiens	42-44
29132432-6	2017	Src and Src-related protein expression in AC-93253 iodide-treated PC9, PC9/gef, and A549 cells were assessed by western blotting.	Iodides	51-57	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
28906032-2	2017	Herein, we communicate an iodide- and silver-mediated C-H/C-H oxidative annulation-aromatization between anilines and allyl alcohols.	Iodides	26-32	churchill domain containing 1	Homo sapiens	54-61
29172645-7	2017	The assay utilizes a cystic fibrosis bronchial epithelial (CFBE41o-) cell line, which was engineered to report CFTR-mediated intracellular flux of iodide by a halide-sensitive yellow fluorescence protein (YFP) reporter.	Iodides	147-153	CF transmembrane conductance regulator	Homo sapiens	111-115
29132432-6	2017	Src and Src-related protein expression in AC-93253 iodide-treated PC9, PC9/gef, and A549 cells were assessed by western blotting.	Iodides	51-57	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	8-11
29132432-6	2017	Src and Src-related protein expression in AC-93253 iodide-treated PC9, PC9/gef, and A549 cells were assessed by western blotting.	Iodides	51-57	proprotein convertase subtilisin/kexin type 9	Homo sapiens	66-69
29132432-6	2017	Src and Src-related protein expression in AC-93253 iodide-treated PC9, PC9/gef, and A549 cells were assessed by western blotting.	Iodides	51-57	proprotein convertase subtilisin/kexin type 9	Homo sapiens	71-74
29132432-12	2017	AC-93253 iodide sensitized tumor cells to gefitinib treatment regardless of whether the cells were gefitinib-sensitive (PC9) or resistant (H1975 and PC9/gef), indicating that it may exert synergistic effects when used in combination with established therapeutic agents.	Iodides	9-15	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	42-45
29028346-6	2017	Dethreading is also found when APT interacts with RNA showing a significant hike of fluorescence (22 times) for displacing iodide ions forming a nanofibrillar network morphology.	Iodides	123-129	LYPLA2 pseudogene 1	Homo sapiens	31-34
29028346-8	2017	Molecular dynamics simulation of a model APT chain in a water box supports the threading at lower pH where the iodide ions pose nearer to the PT chain than that at higher pH causing dethreading.	Iodides	111-117	LYPLA2 pseudogene 1	Homo sapiens	41-44
31966449-6	2017	An in vitro cellular assay using HepG2 hepatocellular carcinoma (HCC) cells exhibited iodide uptake after infection with Ad-Sur-NIS, and the uptake reached a maximum level at 30 min.	Iodides	86-92	solute carrier family 5 member 5	Homo sapiens	128-131
28706256-0	2017	An extremely high dietary iodide supply forestalls severe hypothyroidism in Na+/I- symporter (NIS) knockout mice.	Iodides	26-32	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	76-92
28974598-5	2017	Radiolabelling of iodide or a similar ion allows targeting of the NIS system with radiopharmaceuticals for imaging (123I-radioiodine and 99mTc-pertechnetate) and treatment (131I-radioiodine) by virtue of their gamma ray and beta-particle emissions, respectively.Scintigraphic imaging directly guides 131I-radioiodine treatment planning to maximise therapeutic benefit while minimising adverse reactions, in a personalised medicine approach.	Iodides	18-24	solute carrier family 5 member 5	Homo sapiens	66-69
28881075-5	2017	Density functional theory (DFT) investigations of the reaction energy profiles for [CH3 PPh3 ]X, X=Cl and I showed that in the case of iodide, thermodynamics prevents the production of benzene and favors formation of the carbene.	Iodides	135-141	protein phosphatase 4 catalytic subunit	Homo sapiens	88-92
28796517-0	2017	Computational and Experimental Investigation of the Detection of HO2 Radical and the Products of Its Reaction with Cyclohexene Ozonolysis Derived RO2 Radicals by an Iodide-Based Chemical Ionization Mass Spectrometer.	Iodides	165-171	heme oxygenase 2	Homo sapiens	65-68
28796517-2	2017	In this work, we demonstrate the direct detection of the HO2 radical using an iodide-based chemical ionization mass spectrometer (iodide-CIMS).	Iodides	78-84	heme oxygenase 2	Homo sapiens	57-60
31957294-6	2017	Exchange of the anion from iodide to [NTf2 ] increases the transition times and coloration efficiencies for all the prepared di- and tetracation salts.	Iodides	27-33	nuclear transport factor 2	Homo sapiens	38-42
28528452-5	2017	RESULTS: Overexpression of wild-type p53 as a transgene or pharmacological activation by doxorubicin drug treatment shows significant suppression of NIS transcription in multiple BC cell types which also results in lowered NIS protein content and cellular iodide intake.	Iodides	256-262	tumor protein p53	Homo sapiens	37-40
28706256-0	2017	An extremely high dietary iodide supply forestalls severe hypothyroidism in Na+/I- symporter (NIS) knockout mice.	Iodides	26-32	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	94-97
28706256-1	2017	The sodium/iodide symporter (NIS) mediates active iodide (I-) accumulation in the thyroid, the first step in thyroid hormone (TH) biosynthesis.	Iodides	11-17	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	29-32
28405641-3	2017	Herein, we develop an aggregation-induced emission (AIE) probe HPQ-TBP-I for light up detection of heparin based on the electrostatic interaction-triggered formation of the HPQ-TBP/heparin complex and simultaneous displacement of the fluorescence quencher iodide ion.	Iodides	256-262	TATA-box binding protein	Homo sapiens	67-70
28551984-4	2017	The [(eta2-I2)BiI4]3- subsequently reacted with 1 equiv of iodide to yield [(eta1-I2)BiI5]4-.	Iodides	59-65	DNA polymerase iota	Homo sapiens	6-10
28551984-4	2017	The [(eta2-I2)BiI4]3- subsequently reacted with 1 equiv of iodide to yield [(eta1-I2)BiI5]4-.	Iodides	59-65	secreted phosphoprotein 1	Homo sapiens	77-81
28405641-3	2017	Herein, we develop an aggregation-induced emission (AIE) probe HPQ-TBP-I for light up detection of heparin based on the electrostatic interaction-triggered formation of the HPQ-TBP/heparin complex and simultaneous displacement of the fluorescence quencher iodide ion.	Iodides	256-262	TATA-box binding protein	Homo sapiens	177-180
28229139-4	2017	PtI2(DACH) was obtained through the replacement of bidentate oxalate with two iodides.	Iodides	78-85	dachshund family transcription factor 1	Homo sapiens	5-9
28648509-5	2017	Pendrin has affinity for chloride, iodide, and bicarbonate, among other anions.	Iodides	35-41	solute carrier family 26 member 4	Homo sapiens	0-7
28648509-8	2017	Functional studies have demonstrated that pendrin can mediate iodide efflux in heterologous cells.	Iodides	62-68	solute carrier family 26 member 4	Homo sapiens	42-49
28648509-9	2017	This, together with the thyroid phenotype observed in humans (goiter, impaired iodine organification) suggests that pendrin could be involved in iodide efflux into the lumen, one of the steps required for thyroid hormone synthesis.	Iodides	145-151	solute carrier family 26 member 4	Homo sapiens	116-123
28192058-1	2017	Active iodide (I-) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na+/I- symporter (NIS).	Iodides	7-13	solute carrier family 5 member 5	Homo sapiens	100-116
28088623-5	2017	This study demonstrates that both iodine and iodide are capable of activating the Nrf2 pathway in human skin.	Iodides	45-51	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
28088623-8	2017	The mode of action by which iodine and iodide activate the Nrf2 pathway is discussed.	Iodides	39-45	NFE2 like bZIP transcription factor 2	Homo sapiens	59-63
28192058-1	2017	Active iodide (I-) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na+/I- symporter (NIS).	Iodides	7-13	solute carrier family 5 member 5	Homo sapiens	118-121
28036366-4	2016	hNIS is a glycoprotein that naturally transports iodide (I-) into thyroid cells and has the ability to symport the radiotracer 99mTc-pertechnetate (99mTcO4-).	Iodides	49-55	solute carrier family 5 member 5	Homo sapiens	0-4
28117294-3	2017	The sodium dependent iodide transport activity of the thyroid gland is mainly attributed to the functional expression of the Na+/I- Symporter (NIS) localized at the basolateral membrane of thyrocytes.	Iodides	21-27	solute carrier family 5 member 5	Homo sapiens	125-141
28117294-3	2017	The sodium dependent iodide transport activity of the thyroid gland is mainly attributed to the functional expression of the Na+/I- Symporter (NIS) localized at the basolateral membrane of thyrocytes.	Iodides	21-27	solute carrier family 5 member 5	Homo sapiens	143-146
28003367-7	2017	Intrinsic tryptophan fluorescence studies of CFTR showed that phosphorylation reduced iodide-mediated quenching, consistent with an effect of phosphorylation in burying tryptophans at the transmission interface.	Iodides	86-92	CF transmembrane conductance regulator	Homo sapiens	45-49
27859755-2	2017	In this research, the achiral amphiphile 1-[11-(2-anthracenylmethoxy)-11-oxoundecyl]pyridinium bromide (2-APB), in which the hydrophobic anthracene and the hydrophilic pyridinium units are linked by alkyl chains, was found to form chiral supramolecular assemblies in a cooperative manner in the presence of iodide anion.	Iodides	307-319	arginyl aminopeptidase	Homo sapiens	106-109
27859755-4	2017	By using the same method, 2-APB could assemble together with other pseudo-halogen anions (OCN- , SCN- , SeCN- ) that have similar anionic radius as iodide to form chiral structures.	Iodides	148-154	arginyl aminopeptidase	Homo sapiens	28-31
27859755-4	2017	By using the same method, 2-APB could assemble together with other pseudo-halogen anions (OCN- , SCN- , SeCN- ) that have similar anionic radius as iodide to form chiral structures.	Iodides	148-154	bone gamma-carboxyglutamate protein	Homo sapiens	90-93
27886762-3	2017	In this work, we put forward a simple but effective strategy for colorimetric visualization of lysozyme based on iodide-responsive Cu@Au nanoparticles (Cu@Au NPs) as well as the iodide-catalyzed H2O2-TMB (3,3,5,5-tetramethylbenzidine) reaction system.	Iodides	113-119	lysozyme	Homo sapiens	95-103
28957796-0	2017	Wild-Type P53 Induces Sodium/Iodide Symporter Expression Allowing Radioiodide Therapy in Anaplastic Thyroid Cancer.	Iodides	29-35	tumor protein p53	Homo sapiens	10-13
28133506-0	2017	Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats.	Iodides	52-58	NFE2 like bZIP transcription factor 2	Rattus norvegicus	18-22
28133506-0	2017	Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats.	Iodides	52-58	Kelch-like ECH-associated protein 1	Rattus norvegicus	23-29
28133506-8	2017	We conclude that the activation of the Nrf2-Keap 1 antioxidative defense mechanism may play a crucial role in protecting thyroid function from short-term iodide excess in rats.	Iodides	154-160	NFE2 like bZIP transcription factor 2	Rattus norvegicus	39-43
28133506-8	2017	We conclude that the activation of the Nrf2-Keap 1 antioxidative defense mechanism may play a crucial role in protecting thyroid function from short-term iodide excess in rats.	Iodides	154-160	Kelch-like ECH-associated protein 1	Rattus norvegicus	44-50
28024369-9	2016	Full tunability of the NPl emission wavelength is achieved by varying the halide ion used (bromide, iodide).	Iodides	100-106	N-acetylneuraminate pyruvate lyase	Homo sapiens	23-26
27617682-2	2016	The reactions of aryl bromides or iodides with Ph2 MeSi-BMes2 and Na(OtBu) afforded the desired aryl dimesitylboranes in good to high yields and with high borylation/silylation ratios.	Iodides	34-41	polyhomeotic homolog 2	Homo sapiens	47-50
27997357-5	2016	Insufficient levels of iodide can lead to increased expression or activity of several pathways, including vascular endothelial growth factor (VEGF).	Iodides	23-29	vascular endothelial growth factor A	Homo sapiens	106-140
27997357-5	2016	Insufficient levels of iodide can lead to increased expression or activity of several pathways, including vascular endothelial growth factor (VEGF).	Iodides	23-29	vascular endothelial growth factor A	Homo sapiens	142-146
27997357-8	2016	Varying levels of iodide in the thyroid can influence thyroid carcinoma cell proliferation and angiogenesis via regulation of the hypoxia inducible factor-1 (HIF-1) and VEGF-dependent pathway.	Iodides	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-156
27997357-8	2016	Varying levels of iodide in the thyroid can influence thyroid carcinoma cell proliferation and angiogenesis via regulation of the hypoxia inducible factor-1 (HIF-1) and VEGF-dependent pathway.	Iodides	18-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	158-163
27997357-8	2016	Varying levels of iodide in the thyroid can influence thyroid carcinoma cell proliferation and angiogenesis via regulation of the hypoxia inducible factor-1 (HIF-1) and VEGF-dependent pathway.	Iodides	18-24	vascular endothelial growth factor A	Homo sapiens	169-173
27696875-5	2016	Results of DNA binders displacement and iodide quenching experimental assays unambiguously point to the groove binding mode of Ant-PIm to the DNA-helicate.	Iodides	40-46	solute carrier family 25 member 6	Homo sapiens	127-130
27582097-4	2016	NCC activity was assessed with a novel assay based on thiazide-sensitive iodide uptake in HEK293 cells expressing wild-type or mutant NCC (N59I, R83W, I360T, C421Y, G463R, G731R, L859P, or R861C).	Iodides	73-79	solute carrier family 12 member 3	Homo sapiens	0-3
27638195-0	2016	Thyrotropin and Insulin-Like Growth Factor 1 Receptor Crosstalk Upregulates Sodium-Iodide Symporter Expression in Primary Cultures of Human Thyrocytes.	Iodides	83-89	insulin like growth factor 1	Homo sapiens	16-44
27696875-5	2016	Results of DNA binders displacement and iodide quenching experimental assays unambiguously point to the groove binding mode of Ant-PIm to the DNA-helicate.	Iodides	40-46	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	131-134
27599561-14	2016	In contrast, the iodide symporter gene Slc5a5 was markedly downregulated resulting in impaired iodide uptake and reduced thyroid hormone levels in transgenic thyroid tissue.	Iodides	17-23	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	39-45
27669459-3	2016	ERK signaling, which is markedly increased in thyroid cancer cells driven by oncogenic BRAF, represses the genetic program that enables iodide transport.	Iodides	136-142	mitogen-activated protein kinase 1	Mus musculus	0-3
27669459-3	2016	ERK signaling, which is markedly increased in thyroid cancer cells driven by oncogenic BRAF, represses the genetic program that enables iodide transport.	Iodides	136-142	Braf transforming gene	Mus musculus	87-91
27669459-6	2016	A small increase in ERK inhibition markedly increased the expression of thyroid differentiation genes, increased iodide accumulation in cancer cells, and thereby improved responses to RAI therapy.	Iodides	113-119	mitogen-activated protein kinase 1	Mus musculus	20-23
27669459-8	2016	These data suggest that potent inhibition of ERK signaling is required to adequately induce iodide uptake and indicate that this is a promising strategy for the treatment of BRAF-mutant thyroid cancer.	Iodides	92-98	mitogen-activated protein kinase 1	Mus musculus	45-48
27669459-8	2016	These data suggest that potent inhibition of ERK signaling is required to adequately induce iodide uptake and indicate that this is a promising strategy for the treatment of BRAF-mutant thyroid cancer.	Iodides	92-98	Braf transforming gene	Mus musculus	174-178
27614840-1	2016	The sodium/iodide symporter (NIS), which is essential for iodide concentration in the thyroid, is reported to be transcriptionally regulated by sterol regulatory element-binding proteins (SREBP) in rat FRTL-5 thyrocytes.	Iodides	11-17	solute carrier family 5 member 5	Rattus norvegicus	29-32
27614840-10	2016	Collectively, the present results from cell culture experiments with human mammary epithelial MCF-7 cells and from genetic studies show for the first time that the NIS gene and iodide uptake are regulated by SREBP in cultured human mammary epithelial cells.	Iodides	177-183	solute carrier family 5 member 5	Homo sapiens	164-167
27714322-9	2016	These results are in good agreement with docking experiments and iodide experiments which reinforce TTP"s interactions in the minor groove.	Iodides	65-71	ZFP36 ring finger protein	Homo sapiens	100-103
27603495-1	2016	Inter/intramolecular approaches to sp2 C-N bond formation of N-alkenyl benzimidazoles have been accomplished in the presence of an iodide anion associated with a copper catalyst.	Iodides	131-143	Sp2 transcription factor	Homo sapiens	35-38
27682510-9	2016	We demonstrate in SCID xenografts that focused PDGFRalpha blockade restores iodide transport and decreases tumor burden by &gt;50%.	Iodides	76-82	platelet derived growth factor receptor alpha	Homo sapiens	47-57
27599561-14	2016	In contrast, the iodide symporter gene Slc5a5 was markedly downregulated resulting in impaired iodide uptake and reduced thyroid hormone levels in transgenic thyroid tissue.	Iodides	95-101	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	39-45
27325695-6	2016	Importantly, charge reversal at the first position also reduced the iodide &gt; chloride permeability of ICl,vol This change in selectivity was stronger when both the obligatory LRRC8A subunit and the other co-expressed isoform (LRR8C or -E) carried such mutations.	Iodides	68-74	leucine rich repeat containing 8 VRAC subunit A	Homo sapiens	178-184
27157666-5	2016	Tumor recruitment and vector biodistribution were investigated in vivo in a subcutaneous xenograft mouse model showing high tumor-selective iodide accumulation in cMBP2-PEG-Stp/NIS-treated mice (6.6 +- 1.6% ID/g (123)I, biological half-life 3 hours) by (123)I-scintigraphy.	Iodides	140-146	sulfotransferase family 1A, phenol-preferring, member 1	Mus musculus	173-176
27289446-4	2016	The partial intercalative mode of binding of chelerythrine to the tRNA(phe) was characterized from the steady state anisotropy, iodide ion-induced fluorescence quenching and viscosity measurements.	Iodides	128-134	mitochondrially encoded tRNA glycine	Homo sapiens	66-75
27108928-6	2016	KU-55933, a selective ATM kinase inhibitor, partly rescued NIS expression and iodide transport in DNA-damaged cells.	Iodides	78-84	ATM serine/threonine kinase	Homo sapiens	22-25
26660892-3	2016	Iodide plays an important role in thyroid function at multiple steps of thyroid colloid synthesis and transport among which sodium/iodide symporter (NIS) and pendrin are essential.	Iodides	0-6	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	124-147
26660892-3	2016	Iodide plays an important role in thyroid function at multiple steps of thyroid colloid synthesis and transport among which sodium/iodide symporter (NIS) and pendrin are essential.	Iodides	0-6	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	149-152
26660892-3	2016	Iodide plays an important role in thyroid function at multiple steps of thyroid colloid synthesis and transport among which sodium/iodide symporter (NIS) and pendrin are essential.	Iodides	0-6	solute carrier family 26, member 4	Mus musculus	158-165
26660892-9	2016	Based on these findings, we concluded that the occurrence of thyroid colloid retention exacerbated by excess iodide was associated with the suppression of NIS and pendrin expression, providing an additional insight of the potential mechanism of action of excess iodide on thyroid gland.	Iodides	109-115	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	155-158
26660892-9	2016	Based on these findings, we concluded that the occurrence of thyroid colloid retention exacerbated by excess iodide was associated with the suppression of NIS and pendrin expression, providing an additional insight of the potential mechanism of action of excess iodide on thyroid gland.	Iodides	109-115	solute carrier family 26, member 4	Mus musculus	163-170
26660892-9	2016	Based on these findings, we concluded that the occurrence of thyroid colloid retention exacerbated by excess iodide was associated with the suppression of NIS and pendrin expression, providing an additional insight of the potential mechanism of action of excess iodide on thyroid gland.	Iodides	262-268	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	155-158
26660892-9	2016	Based on these findings, we concluded that the occurrence of thyroid colloid retention exacerbated by excess iodide was associated with the suppression of NIS and pendrin expression, providing an additional insight of the potential mechanism of action of excess iodide on thyroid gland.	Iodides	262-268	solute carrier family 26, member 4	Mus musculus	163-170
27216871-2	2016	Administration of the goitrogen propylthiouracil (PTU) reduces TH production by inhibiting thyroperoxidase (TPO), an enzyme that oxidizes iodide for the synthesis of TH.	Iodides	138-144	thyroid peroxidase	Rattus norvegicus	91-106
27216871-2	2016	Administration of the goitrogen propylthiouracil (PTU) reduces TH production by inhibiting thyroperoxidase (TPO), an enzyme that oxidizes iodide for the synthesis of TH.	Iodides	138-144	thyroid peroxidase	Rattus norvegicus	108-111
26950622-3	2016	In this study, C18 solid phase extraction coupled with electrospray ionization ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) was used to characterize unknown I-DBPs in chloraminated/chlorinated water spiked with iodide and humic substances.	Iodides	263-269	Bardet-Biedl syndrome 9	Homo sapiens	15-18
27109170-8	2016	Additional evidence supporting the formation of new 3beta-Dns-CA or 3beta-NPX-CA assemblies at 40-70 muM was obtained from singlet excited state quenching experiments using iodide.	Iodides	173-179	latexin	Homo sapiens	101-104
27108928-7	2016	Prolonged ATM inhibition in healthy cells also repressed NIS-mediated iodide transport.	Iodides	70-76	ATM serine/threonine kinase	Homo sapiens	10-13
27108928-8	2016	ATM-dependent loss of iodide transport was counteracted by IGF-1.	Iodides	22-28	ATM serine/threonine kinase	Homo sapiens	0-3
27108928-8	2016	ATM-dependent loss of iodide transport was counteracted by IGF-1.	Iodides	22-28	insulin like growth factor 1	Homo sapiens	59-64
27045654-7	2016	Cell iodide uptake in vitro decreased about 50.0% and 37.5%, respectively in above two beta-catenin translocation cell models (both P&lt;0.05).	Iodides	5-11	catenin beta 1	Homo sapiens	87-99
26872612-0	2016	Excess iodide downregulates Na(+)/I(-) symporter gene transcription through activation of PI3K/Akt pathway.	Iodides	7-13	solute carrier family 5 member 5	Rattus norvegicus	28-48
26872612-0	2016	Excess iodide downregulates Na(+)/I(-) symporter gene transcription through activation of PI3K/Akt pathway.	Iodides	7-13	AKT serine/threonine kinase 1	Rattus norvegicus	95-98
26872612-4	2016	Site-directed mutagenesis of Pax8 and NF-kappaB cis-acting elements abrogated the iodide-induced NIS transcription repression.	Iodides	82-88	paired box 8	Rattus norvegicus	29-33
26872612-5	2016	Indeed, excess iodide (10(-3) M) excluded Pax8 from the nucleus, decreased p65 total expression and reduced their transcriptional activity.	Iodides	15-21	paired box 8	Rattus norvegicus	42-46
26872612-5	2016	Indeed, excess iodide (10(-3) M) excluded Pax8 from the nucleus, decreased p65 total expression and reduced their transcriptional activity.	Iodides	15-21	synaptotagmin 1	Rattus norvegicus	75-78
26872612-6	2016	Importantly, p65-Pax8 physical interaction and binding to NIS upstream enhancer were reduced upon iodide treatment.	Iodides	98-104	synaptotagmin 1	Rattus norvegicus	13-16
26872612-6	2016	Importantly, p65-Pax8 physical interaction and binding to NIS upstream enhancer were reduced upon iodide treatment.	Iodides	98-104	paired box 8	Rattus norvegicus	17-21
26872612-7	2016	PI3K/Akt pathway activation by iodide-induced ROS production is involved in the transcriptional repression of NIS expression.	Iodides	31-37	AKT serine/threonine kinase 1	Rattus norvegicus	5-8
26872612-8	2016	In conclusion, the results indicated that excess iodide transcriptionally represses NIS gene expression through the impairment of Pax8 and p65 transcriptional activity.	Iodides	49-55	paired box 8	Rattus norvegicus	130-134
26872612-8	2016	In conclusion, the results indicated that excess iodide transcriptionally represses NIS gene expression through the impairment of Pax8 and p65 transcriptional activity.	Iodides	49-55	synaptotagmin 1	Rattus norvegicus	139-142
26791486-0	2016	Iodide excess regulates its own efflux: a possible involvement of pendrin.	Iodides	0-6	solute carrier family 26 member 4	Rattus norvegicus	66-73
26791486-3	2016	Previous studies demonstrated that pendrin is able to mediate apical efflux of iodide in thyrocytes.	Iodides	79-85	solute carrier family 26 member 4	Rattus norvegicus	35-42
26791486-8	2016	Our results indicate that iodide excess increases pendrin abundance and plasma membrane insertion after 24 h of treatment.	Iodides	26-32	solute carrier family 26 member 4	Rattus norvegicus	50-57
26791486-9	2016	Moreover, iodide excess increases pendrin half-life.	Iodides	10-16	solute carrier family 26 member 4	Rattus norvegicus	34-41
26791486-11	2016	In conclusion, these data suggest that pendrin may have an important role in mediating iodide efflux in thyrocytes, especially under conditions of iodide excess.	Iodides	87-93	solute carrier family 26 member 4	Rattus norvegicus	39-46
26791486-11	2016	In conclusion, these data suggest that pendrin may have an important role in mediating iodide efflux in thyrocytes, especially under conditions of iodide excess.	Iodides	147-153	solute carrier family 26 member 4	Rattus norvegicus	39-46
26754589-7	2016	CONCLUSION: We concluded that PTU, KClO4, or TSH relieved the mitochondrial oxidative stress induced by high concentrations of iodide in the thyroids of both MT-I/II KO and WT mice.	Iodides	127-133	metallothionein 1	Mus musculus	158-168
26754589-8	2016	MT-I/II showed antioxidant effects against high concentrations of iodide-induced mitochondrial superoxide production in the thyroid.	Iodides	66-72	metallothionein 3	Mus musculus	0-7
26754589-0	2016	Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice.	Iodides	95-101	metallothionein 1	Mus musculus	168-185
26786359-8	2016	AuStNPs are advantageous for SPR sensing, as it was demonstrated in the sensitive detection of not only thiols, such as ampicillin, but also iodide with the detection limit of 3.2 pM (0.4 ng L(-1)).	Iodides	141-147	sepiapterin reductase	Homo sapiens	29-32
27026839-4	2016	Silver-kaolinite (AgK) material is prepared as an additive to improve the iodide retention capacity of bentonite.	Iodides	74-80	acylglycerol kinase	Homo sapiens	18-21
26253438-5	2016	The detection limit of iodide anion is calculated as 0.77muM.	Iodides	23-35	latexin	Homo sapiens	57-60
26745029-0	2016	Production of Molecular Iodine and Tri-iodide in the Frozen Solution of Iodide: Implication for Polar Atmosphere.	Iodides	72-78	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	35-38
26745029-3	2016	Here, we demonstrate that the production of tri-iodide (I3(-)) via iodide oxidation, which is negligible in aqueous solution, is significantly accelerated in frozen solution, both in the presence and the absence of solar irradiation.	Iodides	48-54	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	44-47
26745029-5	2016	The emission of gaseous I2 from the irradiated frozen solution of iodide to the gas phase was detected by using cavity ring-down spectroscopy, which was observed both in the frozen state at 253 K and after thawing the ice at 298 K. The accelerated (photo-)oxidation of iodide and the subsequent formation of tri-iodide and I2 in ice appear to be related with the freeze concentration of iodide and dissolved O2 trapped in the ice crystal grain boundaries.	Iodides	66-72	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	308-311
26621281-2	2015	In 6 weeks, the serum level of Na(+)/I(-) symporter responsible for the transport of iodides into follicular thyrocytes decreased, while serum concentration of thyroperoxidase increased.	Iodides	85-92	solute carrier family 5 member 5	Rattus norvegicus	31-51
26506010-2	2016	Iodide Organification defects (IOD) represent 10% of cases of congenital hypothyroidism (CH) being the main genes affected that of TPO (thyroid peroxidase) and DUOX2 (dual oxidasa 2).	Iodides	0-6	thyroid peroxidase	Homo sapiens	131-134
26506010-2	2016	Iodide Organification defects (IOD) represent 10% of cases of congenital hypothyroidism (CH) being the main genes affected that of TPO (thyroid peroxidase) and DUOX2 (dual oxidasa 2).	Iodides	0-6	thyroid peroxidase	Homo sapiens	136-154
26506010-2	2016	Iodide Organification defects (IOD) represent 10% of cases of congenital hypothyroidism (CH) being the main genes affected that of TPO (thyroid peroxidase) and DUOX2 (dual oxidasa 2).	Iodides	0-6	dual oxidase 2	Homo sapiens	160-165
26506010-2	2016	Iodide Organification defects (IOD) represent 10% of cases of congenital hypothyroidism (CH) being the main genes affected that of TPO (thyroid peroxidase) and DUOX2 (dual oxidasa 2).	Iodides	0-6	dual oxidase 2	Homo sapiens	167-181
27161422-4	2016	METHODS: Pendrin activity was evaluated by measuring pendrin-dependent iodide influx following overexpression of the transporter in a human kidney cell line, in the presence of selected test compounds or the respective vehicles.	Iodides	71-77	solute carrier family 26 member 4	Homo sapiens	9-16
27161422-4	2016	METHODS: Pendrin activity was evaluated by measuring pendrin-dependent iodide influx following overexpression of the transporter in a human kidney cell line, in the presence of selected test compounds or the respective vehicles.	Iodides	71-77	solute carrier family 26 member 4	Homo sapiens	53-60
26801661-4	2015	Meanwhile, at the molecular level, PCB congeners may activate phosphorylation of Akt, p-Akt, and forkhead box O3a (FoxO3a) protein resulting in inhibition of the natrium/iodide symporter.	Iodides	170-176	pyruvate carboxylase	Homo sapiens	35-38
26801661-4	2015	Meanwhile, at the molecular level, PCB congeners may activate phosphorylation of Akt, p-Akt, and forkhead box O3a (FoxO3a) protein resulting in inhibition of the natrium/iodide symporter.	Iodides	170-176	forkhead box O3	Homo sapiens	115-121
26801661-4	2015	Meanwhile, at the molecular level, PCB congeners may activate phosphorylation of Akt, p-Akt, and forkhead box O3a (FoxO3a) protein resulting in inhibition of the natrium/iodide symporter.	Iodides	170-176	AKT serine/threonine kinase 1	Homo sapiens	81-84
26801661-4	2015	Meanwhile, at the molecular level, PCB congeners may activate phosphorylation of Akt, p-Akt, and forkhead box O3a (FoxO3a) protein resulting in inhibition of the natrium/iodide symporter.	Iodides	170-176	forkhead box O3	Homo sapiens	97-113
26599396-1	2015	PURPOSE: Human sodium/iodide symporter (hNIS) protein is a membrane glycoprotein that transports iodide ions into thyroid cells.	Iodides	22-28	solute carrier family 5 member 5	Homo sapiens	40-44
26478542-5	2015	Thyroid peroxidase (TPO) iodide oxidation activity was measured in vitro, and TPO protein was assessed on Western blots.	Iodides	25-31	thyroid peroxidase	Canis lupus familiaris	0-18
26478542-5	2015	Thyroid peroxidase (TPO) iodide oxidation activity was measured in vitro, and TPO protein was assessed on Western blots.	Iodides	25-31	thyroid peroxidase	Canis lupus familiaris	20-23
26384784-3	2015	Here, we studied 2-(4-hexyloxybenzyl)-1-methylquinuclidin-1-ium iodide (designated as 8d), on ion currents elicited by choline, ICh, (Ch, a selective agonist for alpha7-containing nAChRs), recorded in interneurons from the stratum radiatum of the rat hippocampal CA1 region by using the whole-cell voltage-clamp technique.	Iodides	64-70	carbonic anhydrase 1	Rattus norvegicus	263-266
26313899-0	2015	Pendrin and anoctamin as mediators of apical iodide efflux in thyroid cells.	Iodides	45-51	solute carrier family 26 member 4	Homo sapiens	0-7
26282166-7	2015	Specifically, we found that miR-146b-3p binds to the 3"-untranslated region of PAX8 and sodium/iodide symporter (NIS), leading to impaired protein translation and a subsequent reduction in iodide uptake.	Iodides	95-101	microRNA 146b	Homo sapiens	28-36
26282166-7	2015	Specifically, we found that miR-146b-3p binds to the 3"-untranslated region of PAX8 and sodium/iodide symporter (NIS), leading to impaired protein translation and a subsequent reduction in iodide uptake.	Iodides	95-101	solute carrier family 5 member 5	Homo sapiens	113-116
26282166-9	2015	In conclusion, our study has uncovered the existence of a miR-146b-3p/PAX8/NIS regulatory circuit that may be exploited therapeutically to modulate thyroid cell differentiation and iodide uptake for improved treatment of advanced thyroid cancer.	Iodides	181-187	microRNA 146b	Homo sapiens	58-66
26282166-9	2015	In conclusion, our study has uncovered the existence of a miR-146b-3p/PAX8/NIS regulatory circuit that may be exploited therapeutically to modulate thyroid cell differentiation and iodide uptake for improved treatment of advanced thyroid cancer.	Iodides	181-187	paired box 8	Homo sapiens	70-74
26282166-9	2015	In conclusion, our study has uncovered the existence of a miR-146b-3p/PAX8/NIS regulatory circuit that may be exploited therapeutically to modulate thyroid cell differentiation and iodide uptake for improved treatment of advanced thyroid cancer.	Iodides	181-187	solute carrier family 5 member 5	Homo sapiens	75-78
26313899-8	2015	Recently, Anoctamin 1 (TMEM16A), a calcium-activated anion channel has been identified at the apical membrane of thyrocytes and functional studies suggest that it may play a predominant role in mediating iodide efflux.	Iodides	204-210	anoctamin 1	Homo sapiens	23-30
26313899-9	2015	SUMMARY: Anoctamin and pendrin are two plausible candidates as mediators of apical iodide efflux.	Iodides	83-89	solute carrier family 26 member 4	Homo sapiens	23-30
26444544-7	2015	When iodide was added, it was transported into donor cells by SLC26A4, diffused through the GJs to acceptor cells, and quenched the YFP(QL) fluorescence.	Iodides	5-11	solute carrier family 26 member 4	Homo sapiens	62-69
26115738-1	2015	The sodium/iodide symporter (NIS) is involved in iodide uptake and has been used for the diagnosis and treatment of thyroid cancer.	Iodides	11-17	solute carrier family 5 member 5	Rattus norvegicus	29-32
26115738-1	2015	The sodium/iodide symporter (NIS) is involved in iodide uptake and has been used for the diagnosis and treatment of thyroid cancer.	Iodides	49-55	solute carrier family 5 member 5	Rattus norvegicus	29-32
26313899-5	2015	RECENT FINDINGS: The functional characterization of pendrin (PDS/SLC26A4), a multifunctional anion exchanger, suggested that it could be involved in mediating iodide efflux.	Iodides	159-165	solute carrier family 26 member 4	Homo sapiens	52-59
26313899-5	2015	RECENT FINDINGS: The functional characterization of pendrin (PDS/SLC26A4), a multifunctional anion exchanger, suggested that it could be involved in mediating iodide efflux.	Iodides	159-165	solute carrier family 26 member 4	Homo sapiens	65-72
26313899-8	2015	Recently, Anoctamin 1 (TMEM16A), a calcium-activated anion channel has been identified at the apical membrane of thyrocytes and functional studies suggest that it may play a predominant role in mediating iodide efflux.	Iodides	204-210	anoctamin 1	Homo sapiens	10-21
26204134-1	2015	CONTEXT: Iodide (I(-)), an essential constituent of the thyroid hormones, is actively accumulated in the thyroid by the Na(+)/I(-) symporter (NIS), a key plasma membrane protein encoded by the slc5a5 gene.	Iodides	9-15	solute carrier family 5 member 5	Homo sapiens	120-140
26204134-1	2015	CONTEXT: Iodide (I(-)), an essential constituent of the thyroid hormones, is actively accumulated in the thyroid by the Na(+)/I(-) symporter (NIS), a key plasma membrane protein encoded by the slc5a5 gene.	Iodides	9-15	solute carrier family 5 member 5	Homo sapiens	193-199
25745085-7	2015	RESULTS: Results show robust MSC recruitment with RANTES/CCL5-promoter activation within the stroma of liver metastases as evidenced by tumor-selective iodide accumulation, immunohistochemistry, and real-time polymerase chain reaction.	Iodides	152-158	chemokine (C-C motif) ligand 5	Mus musculus	50-56
26285906-6	2015	This review covers the three known iodide transporters - the sodium iodide symporter, pendrin and the sodium-coupled monocarboxylate transporter - and their role in iodide transport in breast cells, along with efforts to manipulate them to increase the potential for radioiodide therapy as a treatment for breast cancer.	Iodides	35-41	solute carrier family 26 member 4	Homo sapiens	86-93
25905405-8	2000	TPO sits at the apical plasma membrane, where it reduces H2O2, elevating the oxidation state of iodide to an iodinating species, and attaches the iodine to tyrosyls in Tg.	Iodides	96-102	thyroid peroxidase	Homo sapiens	0-3
26151430-1	2015	Reductive dehalogenation such as that catalyzed by iodotyrosine deiodinase (IYD) is highly unusual in aerobic organisms but necessary for iodide salvage from iodotyrosine generated during thyroxine biosynthesis.	Iodides	138-144	iodotyrosine deiodinase	Homo sapiens	51-74
26151430-1	2015	Reductive dehalogenation such as that catalyzed by iodotyrosine deiodinase (IYD) is highly unusual in aerobic organisms but necessary for iodide salvage from iodotyrosine generated during thyroxine biosynthesis.	Iodides	138-144	iodotyrosine deiodinase	Homo sapiens	76-79
26079370-3	2015	In Baby Hamster Kidney (BHK) cells expressing wild-type human CFTR, S1P (1mumol/L) attenuates forskolin-stimulated, CFTR-dependent iodide efflux.	Iodides	131-137	CF transmembrane conductance regulator	Homo sapiens	62-66
26079370-3	2015	In Baby Hamster Kidney (BHK) cells expressing wild-type human CFTR, S1P (1mumol/L) attenuates forskolin-stimulated, CFTR-dependent iodide efflux.	Iodides	131-137	CF transmembrane conductance regulator	Homo sapiens	116-120
25595679-5	2015	This inhibition may occur because GSH acts as a competitive substrate for hydrogen peroxide, or possibly reduce the oxidized form of iodide, requirements for TPO action.	Iodides	133-139	thyroid peroxidase	Homo sapiens	158-161
25460880-3	2015	Based on this new discovery, we have developed a novel, cost-effective and sandwich-type fluorescence turn-on aptasensor for highly sensitive and specific thrombin detection, what took advantage of aptamer-conjugated magnetic beads (apt-MBs) for protein capture and separation, and iodide-induced fluorescence recovery of activatable polyA-based AuNP probes through ligand displacement for fluorescence turn-on detection.	Iodides	282-288	coagulation factor II, thrombin	Homo sapiens	155-163
25745085-7	2015	RESULTS: Results show robust MSC recruitment with RANTES/CCL5-promoter activation within the stroma of liver metastases as evidenced by tumor-selective iodide accumulation, immunohistochemistry, and real-time polymerase chain reaction.	Iodides	152-158	chemokine (C-C motif) ligand 5	Mus musculus	57-61
25428514-8	2015	Therefore, the iodide content of tap water, urine and blood serum is monitored using this sensor and it is found that the sensor can detect a range of iodide in tap water, urine and blood serum.	Iodides	15-21	nuclear RNA export factor 1	Homo sapiens	33-36
25576858-2	2015	BACKGROUND: Human thyroperoxidase (hTPO) is a membrane-bound glycoprotein located at the apical membrane of the thyroid follicular cells which catalyzes iodide oxidation and organification in the thyroglobulin (TG) tyrosine residues, leading to the thyroid hormone synthesis by coupling of iodotyrosine residues.	Iodides	153-159	thyroid peroxidase	Homo sapiens	18-33
25576858-2	2015	BACKGROUND: Human thyroperoxidase (hTPO) is a membrane-bound glycoprotein located at the apical membrane of the thyroid follicular cells which catalyzes iodide oxidation and organification in the thyroglobulin (TG) tyrosine residues, leading to the thyroid hormone synthesis by coupling of iodotyrosine residues.	Iodides	153-159	thyroid peroxidase	Homo sapiens	35-39
25611970-7	2015	H2O2 is thus consumed in a catalytic cycle and leads to less efficient HOBr scavenging at even low iodide concentrations (&lt;1 muM).	Iodides	99-105	latexin	Homo sapiens	128-131
26312884-12	2015	In response to increased intracellular calcium, ANO4-transfected cells triggered a lower flow of iodide than did other anoctamins.	Iodides	97-103	anoctamin 4	Homo sapiens	48-52
25428514-8	2015	Therefore, the iodide content of tap water, urine and blood serum is monitored using this sensor and it is found that the sensor can detect a range of iodide in tap water, urine and blood serum.	Iodides	15-21	nuclear RNA export factor 1	Homo sapiens	161-164
25428514-8	2015	Therefore, the iodide content of tap water, urine and blood serum is monitored using this sensor and it is found that the sensor can detect a range of iodide in tap water, urine and blood serum.	Iodides	151-157	nuclear RNA export factor 1	Homo sapiens	33-36
25428514-8	2015	Therefore, the iodide content of tap water, urine and blood serum is monitored using this sensor and it is found that the sensor can detect a range of iodide in tap water, urine and blood serum.	Iodides	151-157	nuclear RNA export factor 1	Homo sapiens	161-164
25615643-1	2015	PURPOSE: The aim of this study was to design a method of radionuclide for imaging and therapy of nasopharyngeal carcinoma (NPC) using the transferred human sodium/iodide symporter (hNIS) gene.	Iodides	163-169	solute carrier family 5 member 5	Homo sapiens	181-185
25395621-2	2015	The flavoprotein iodotyrosine deiodinase (IYD) is responsible for iodide salvage by reductive deiodination of the iodotyrosine derivatives formed as byproducts of thyroid hormone biosynthesis.	Iodides	66-72	iodotyrosine deiodinase	Homo sapiens	17-40
25513753-6	2015	Iodide sensing is conducted in buffer solutions as well as in lake water with limits of detection in the range of 1 muM (127 mug L(-1)) and 2 muM (254 mug L(-1)), respectively.	Iodides	0-6	latexin	Homo sapiens	116-119
25513753-6	2015	Iodide sensing is conducted in buffer solutions as well as in lake water with limits of detection in the range of 1 muM (127 mug L(-1)) and 2 muM (254 mug L(-1)), respectively.	Iodides	0-6	latexin	Homo sapiens	142-145
25395621-2	2015	The flavoprotein iodotyrosine deiodinase (IYD) is responsible for iodide salvage by reductive deiodination of the iodotyrosine derivatives formed as byproducts of thyroid hormone biosynthesis.	Iodides	66-72	iodotyrosine deiodinase	Homo sapiens	42-45
25328990-0	2015	A truncating TPO mutation (Y55X) in patients with hypothyroidism and total iodide organification defect.	Iodides	75-81	thyroid peroxidase	Homo sapiens	13-16
25447156-7	2015	A series of intensive studies showed that oridonin remarkably reduced iodide influx in wt-CFTR and DeltaF508-CFTR FRT epithelial cells in a dose-dependent and irreversible way.	Iodides	70-76	cystic fibrosis transmembrane conductance regulator	Mus musculus	90-94
26370556-2	2015	Tg significantly suppressed the expression of genes necessary for iodide transport and TH synthesis by counteracting stimulation by TSH.	Iodides	66-72	thyroglobulin	Rattus norvegicus	0-2
25472496-2	2014	These formal SN-type reactions generate valuable (hetero)aryl/alkenyl nitriles, iodides, and bromides as well as allylated indoles using a bench-stable Co(III) catalyst.	Iodides	80-87	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	152-159
25410753-12	2015	An effective therapy of (131)I was achieved activity in malignant glioma cells after induction of tumor-specific iodide uptake activity by GFAP promoter-directed hNIS gene expression in vitro and in vivo.	Iodides	113-119	glial fibrillary acidic protein	Homo sapiens	139-143
25410753-12	2015	An effective therapy of (131)I was achieved activity in malignant glioma cells after induction of tumor-specific iodide uptake activity by GFAP promoter-directed hNIS gene expression in vitro and in vivo.	Iodides	113-119	solute carrier family 5 member 5	Homo sapiens	162-166
26101557-0	2015	Metallothionein-I/II Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure.	Iodides	139-145	metallothionein 3	Mus musculus	0-20
25817866-1	2015	The Na(+)/multivitamin transporter (SMVT) is a member of the solute:sodium symporter family that catalyzes the Na(+)-dependent uptake of the structurally diverse water-soluble vitamins pantothenic acid (vitamin B5) and biotin (vitamin H), alpha-lipoic acid-a vitamin-like substance with strong antioxidant properties-and iodide.	Iodides	321-327	solute carrier family 5 member 6	Homo sapiens	36-40
25298423-5	2014	Moreover, ANO1 properties, i.e., activation by intracellular calcium (i.e., by ionomycin or by ATP), low but positive affinity for pertechnetate, and nonrequirement for chloride, better fit with the iodide release characteristics of PCCl3 and FRTL-5 rat thyroid cell lines than the dissimilar properties of pendrin.	Iodides	199-205	anoctamin 1	Rattus norvegicus	10-14
25298423-5	2014	Moreover, ANO1 properties, i.e., activation by intracellular calcium (i.e., by ionomycin or by ATP), low but positive affinity for pertechnetate, and nonrequirement for chloride, better fit with the iodide release characteristics of PCCl3 and FRTL-5 rat thyroid cell lines than the dissimilar properties of pendrin.	Iodides	199-205	solute carrier family 26 member 4	Rattus norvegicus	307-314
25298423-1	2014	Iodide is captured by thyrocytes through the Na(+)/I(-) symporter (NIS) before being released into the follicular lumen, where it is oxidized and incorporated into thyroglobulin for the production of thyroid hormones.	Iodides	0-6	solute carrier family 5 member 5	Rattus norvegicus	45-65
25298423-6	2014	Most importantly, iodide release by PCCl3 and FRTL-5 cells is efficiently blocked by T16Ainh-A01, an ANO1-specific inhibitor, and upon ANO1 knockdown by RNA interference.	Iodides	18-24	anoctamin 1	Rattus norvegicus	101-105
25298423-2	2014	Several reports point to pendrin as a candidate protein for iodide export from thyroid cells into the follicular lumen.	Iodides	60-66	solute carrier family 26 member 4	Rattus norvegicus	25-32
25298423-6	2014	Most importantly, iodide release by PCCl3 and FRTL-5 cells is efficiently blocked by T16Ainh-A01, an ANO1-specific inhibitor, and upon ANO1 knockdown by RNA interference.	Iodides	18-24	anoctamin 1	Rattus norvegicus	135-139
25298423-3	2014	Here, we show that a recently discovered Ca(2+)-activated anion channel, TMEM16A or anoctamin-1 (ANO1), also exports iodide from rat thyroid cell lines and from HEK 293T cells expressing human NIS and ANO1.	Iodides	117-123	anoctamin 1	Rattus norvegicus	73-80
25298423-3	2014	Here, we show that a recently discovered Ca(2+)-activated anion channel, TMEM16A or anoctamin-1 (ANO1), also exports iodide from rat thyroid cell lines and from HEK 293T cells expressing human NIS and ANO1.	Iodides	117-123	anoctamin 1	Rattus norvegicus	84-95
25298423-8	2014	In conclusion, our data strongly suggest that ANO1 is responsible for most of the iodide efflux across the apical membrane of thyroid cells.	Iodides	82-88	anoctamin 1	Rattus norvegicus	46-50
25298423-3	2014	Here, we show that a recently discovered Ca(2+)-activated anion channel, TMEM16A or anoctamin-1 (ANO1), also exports iodide from rat thyroid cell lines and from HEK 293T cells expressing human NIS and ANO1.	Iodides	117-123	anoctamin 1	Rattus norvegicus	97-101
25280130-6	2014	Sample self-stacking is developed as a novel online sample preconcentration method to boost sensitivity with submicromolar detection limits for iodide (S/N   3, 0.06 muM) directly in urine.	Iodides	144-150	latexin	Homo sapiens	166-169
25298423-3	2014	Here, we show that a recently discovered Ca(2+)-activated anion channel, TMEM16A or anoctamin-1 (ANO1), also exports iodide from rat thyroid cell lines and from HEK 293T cells expressing human NIS and ANO1.	Iodides	117-123	anoctamin 1	Homo sapiens	201-205
25480962-9	2014	The C. elegans dual oxidase maturation factor DOXA-1 is also required for the arresting effect of excess iodide.	Iodides	105-111	Dual oxidase maturation factor 1	Caenorhabditis elegans	46-52
25480962-10	2014	Finally, we detected a dramatically increased biogenesis of reactive oxygen species in animals treated with excess iodide, and this effect can be partially suppressed by bli-3 and tsp-15 mutations.	Iodides	115-121	Dual oxidase 1	Caenorhabditis elegans	170-175
25480962-10	2014	Finally, we detected a dramatically increased biogenesis of reactive oxygen species in animals treated with excess iodide, and this effect can be partially suppressed by bli-3 and tsp-15 mutations.	Iodides	115-121	Tetraspanin-15	Caenorhabditis elegans	180-186
25480962-11	2014	We propose that the BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for the toxic pleiotropic effects of excess iodide.	Iodides	117-123	Dual oxidase 1	Caenorhabditis elegans	20-25
25480962-11	2014	We propose that the BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for the toxic pleiotropic effects of excess iodide.	Iodides	117-123	Tetraspanin-15	Caenorhabditis elegans	26-32
25480962-11	2014	We propose that the BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for the toxic pleiotropic effects of excess iodide.	Iodides	117-123	Dual oxidase maturation factor 1	Caenorhabditis elegans	33-39
25280130-8	2014	Rigorous method validation confirmed good linearity (R(2) = 0.9998), dynamic range (0.20 to 4.0 muM), accuracy (average recovery of 93% at three concentration levels) and precision for reliable iodide determination in pooled urine specimens over 29 days of analysis (RSD = 11%, n = 87).	Iodides	194-200	latexin	Homo sapiens	96-99
25158262-0	2014	Correlations of iodide ions with vascular endothelial growth factor and its receptors during the proliferation of vascular endothelial cells.	Iodides	16-22	vascular endothelial growth factor A	Homo sapiens	33-67
25056090-4	2014	Moreover, the iodide-sensing ability of receptor PPT-1 was explored among the ten examined anions.	Iodides	14-20	palmitoyl-protein thioesterase 1	Homo sapiens	49-54
25309780-1	2014	Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS).	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	164-167
25158262-1	2014	The aim of this study was to explore the correlations of iodide ions with vascular endothelial growth factor (VEGF) and its receptors during the proliferation of vascular endothelial cells (VECs).	Iodides	57-63	vascular endothelial growth factor A	Homo sapiens	74-108
25158262-1	2014	The aim of this study was to explore the correlations of iodide ions with vascular endothelial growth factor (VEGF) and its receptors during the proliferation of vascular endothelial cells (VECs).	Iodides	57-63	vascular endothelial growth factor A	Homo sapiens	110-114
25158262-3	2014	The effect of iodide ions on the phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR-2) was observed using Western blot analysis.	Iodides	14-20	kinase insert domain receptor	Homo sapiens	52-97
25158262-3	2014	The effect of iodide ions on the phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR-2) was observed using Western blot analysis.	Iodides	14-20	kinase insert domain receptor	Homo sapiens	99-106
25158262-5	2014	At a certain concentration, iodide ions upregulated the phosphorylation level of VEGFR-2 at the Tyr1214 site (P &lt; 0.05).	Iodides	28-34	kinase insert domain receptor	Homo sapiens	81-88
24939862-6	2014	Reaction of 2-I with the N-heterocyclic carbene IMe4 (IMe4 = 1,3,4,5-tetramethylimidazolin-2-ylidene) leads, after displacement of the iodide groups, to the unprecedented diiodide salt [Si(IMe4)2{C4(NEt2)4}](I)2 (3), containing a 1H-silole dication with a four-coordinate Si(IV) center.	Iodides	135-141	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	48-52
24921222-1	2014	Typical urinary iodide concentrations range from 0.3 muM to 6.0 muM.	Iodides	16-22	latexin	Homo sapiens	53-56
24921222-1	2014	Typical urinary iodide concentrations range from 0.3 muM to 6.0 muM.	Iodides	16-22	latexin	Homo sapiens	64-67
24921222-8	2014	In both of the calibration plots, linear relationships were found between the reduction peak height and the iodide ion concentration of 0.3 muM to 6.0 muM.	Iodides	108-114	latexin	Homo sapiens	140-143
24921222-8	2014	In both of the calibration plots, linear relationships were found between the reduction peak height and the iodide ion concentration of 0.3 muM to 6.0 muM.	Iodides	108-114	latexin	Homo sapiens	151-154
24964735-0	2014	The distribution of iodide at the sea surface.	Iodides	20-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	34-37
24964735-1	2014	Recent studies have highlighted the impact of sea surface iodide concentrations on the deposition of ozone to the sea surface and the sea to air flux of reactive iodine.	Iodides	58-64	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	46-49
24964735-1	2014	Recent studies have highlighted the impact of sea surface iodide concentrations on the deposition of ozone to the sea surface and the sea to air flux of reactive iodine.	Iodides	58-64	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	114-117
24964735-1	2014	Recent studies have highlighted the impact of sea surface iodide concentrations on the deposition of ozone to the sea surface and the sea to air flux of reactive iodine.	Iodides	58-64	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	114-117
24964735-2	2014	The use of models to predict this flux demands accurate, spatially distributed sea surface iodide concentrations, but to date, the observational data required to support this is sparse and mostly arises from independent studies conducted on small geographical and temporal scales.	Iodides	91-97	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	79-82
24964735-5	2014	Of the variables tested, sea surface temperature is the strongest predictor of iodide concentration.	Iodides	79-85	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	25-28
24939862-6	2014	Reaction of 2-I with the N-heterocyclic carbene IMe4 (IMe4 = 1,3,4,5-tetramethylimidazolin-2-ylidene) leads, after displacement of the iodide groups, to the unprecedented diiodide salt [Si(IMe4)2{C4(NEt2)4}](I)2 (3), containing a 1H-silole dication with a four-coordinate Si(IV) center.	Iodides	135-141	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	54-58
24939862-6	2014	Reaction of 2-I with the N-heterocyclic carbene IMe4 (IMe4 = 1,3,4,5-tetramethylimidazolin-2-ylidene) leads, after displacement of the iodide groups, to the unprecedented diiodide salt [Si(IMe4)2{C4(NEt2)4}](I)2 (3), containing a 1H-silole dication with a four-coordinate Si(IV) center.	Iodides	135-141	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	54-58
24788249-8	2014	Furthermore, iodide efflux assays confirmed that NHERF1 and P-ERM are necessary for VIP regulation of the stability and sustained activity of membrane CFTR.	Iodides	13-19	SLC9A3 regulator 1	Homo sapiens	49-55
24788249-8	2014	Furthermore, iodide efflux assays confirmed that NHERF1 and P-ERM are necessary for VIP regulation of the stability and sustained activity of membrane CFTR.	Iodides	13-19	vasoactive intestinal peptide	Homo sapiens	84-87
24788249-8	2014	Furthermore, iodide efflux assays confirmed that NHERF1 and P-ERM are necessary for VIP regulation of the stability and sustained activity of membrane CFTR.	Iodides	13-19	CF transmembrane conductance regulator	Homo sapiens	151-155
25104093-7	2014	Furthermore, an antagonistic interaction between fluoride and excessive iodide exists, and cytotoxicity may be related to IRE1 pathway-induced apoptosis.	Iodides	72-78	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	122-126
24708099-0	2014	NIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian cancer.	Iodides	13-19	solute carrier family 5 member 5	Homo sapiens	0-3
24708099-1	2014	CONTEXT: The sodium iodide symporter (NIS) mediates active transport of iodide into the thyroid and the lactating mammary glands and is highly expressed in thyroid and breast carcinomas.	Iodides	20-26	solute carrier family 5 member 5	Homo sapiens	38-41
24691731-1	2014	Iodide uptake by thyroid cells is mediated by a transmembrane glycoprotein known as the Na+/I--symporter (NIS).	Iodides	0-6	solute carrier family 5 member 5	Rattus norvegicus	88-104
24879795-0	2014	The thyroxine-containing thyroglobulin peptide (aa 2549-2560) is a target epitope in iodide-accelerated spontaneous autoimmune thyroiditis.	Iodides	85-91	thyroglobulin	Mus musculus	25-38
24879795-4	2014	In ISAT, activated CD4+ T cells specific for T4p2553 are detected before the disease onset in thyroid-draining cervical lymph nodes only in mice placed on an iodide-rich diet and not in age-matched controls.	Iodides	158-164	CD4 antigen	Mus musculus	19-22
24760039-0	2014	A cationic copper(I) iodide cluster MOF exhibiting unusual ligand assisted thermochromism.	Iodides	18-27	lysine acetyltransferase 8	Homo sapiens	36-39
24888603-0	2014	Physiological sodium concentrations enhance the iodide affinity of the Na+/I- symporter.	Iodides	48-54	solute carrier family 5 member 5	Homo sapiens	71-87
24632415-7	2014	Bromide, iodide and sulfite also protected GSTZ1 from inactivation by DCA, however fluoride, sulfate, carbonate, acetate, cyanide did not.	Iodides	9-15	glutathione S-transferase zeta 1	Homo sapiens	43-48
24691731-4	2014	Recently, our group showed that AMP-activated protein kinase (AMPK) plays a pivotal role in the rat thyroid gland, downregulating iodide uptake, NIS protein, and mRNA content.	Iodides	130-136	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	32-60
24691731-4	2014	Recently, our group showed that AMP-activated protein kinase (AMPK) plays a pivotal role in the rat thyroid gland, downregulating iodide uptake, NIS protein, and mRNA content.	Iodides	130-136	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	62-66
24400871-7	2014	Here, we identified Apigenin, a plant-derived flavonoid, as a reagent to further enhance the iodide influx rate increased by Akt inhibition in thyroid cells under acute TSH stimulation.	Iodides	93-99	AKT serine/threonine kinase 1	Rattus norvegicus	125-128
24591578-4	2014	Both G550E and 4RK augmented strongly CFTR-mediated iodide efflux from BHK cells expressing G551D-CFTR.	Iodides	52-58	cystic fibrosis transmembrane conductance regulator	Mesocricetus auratus	38-42
24591578-4	2014	Both G550E and 4RK augmented strongly CFTR-mediated iodide efflux from BHK cells expressing G551D-CFTR.	Iodides	52-58	cystic fibrosis transmembrane conductance regulator	Mesocricetus auratus	98-102
24714160-6	2014	Both compounds dose-dependently blocked CFTR-mediated iodide influx with IC50 around 20 muM.	Iodides	54-60	CF transmembrane conductance regulator	Rattus norvegicus	40-44
24884806-1	2014	BACKGROUND: Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia.	Iodides	46-52	solute carrier family 5 member 5	Homo sapiens	64-67
24424051-0	2014	The acute inhibitory effect of iodide excess on sodium/iodide symporter expression and activity involves the PI3K/Akt signaling pathway.	Iodides	31-37	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
24567234-3	2014	Devices constructed using the N719 dye and iodide/triiodide as the redox mediator in the electrolyte yielded energy conversion efficiencies (eta = 6.1 +- 0.2%), which were marginally lower than for devices made with the commonly used P25 titania films (eta = 6.3 +- 0.1%) under one sun simulated solar radiation.	Iodides	43-49	tubulin polymerization promoting protein	Homo sapiens	234-237
27919039-6	2014	In the thyroid field, AMPK emerged as a novel important intracellular pathway, since it regulates both iodide and glucose uptakes in normal thyroid cells.	Iodides	103-109	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	22-26
24592856-1	2014	We report a DFT study of interaction between the Ru complex sensitizer [Ru(dcbpy)2(NCS)2: dcbpy = 4,4"-dicarboxy-2,2"-bipyridyl] (N3) and iodide ion under the influence of different deprotonation situations.	Iodides	138-144	cytosolic thiouridylase subunit 2	Homo sapiens	83-88
24424051-0	2014	The acute inhibitory effect of iodide excess on sodium/iodide symporter expression and activity involves the PI3K/Akt signaling pathway.	Iodides	55-61	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
24053146-4	2014	Although SCN(-) is the physiological substrate of LPO, the Duox/LPO/halide system can generate hypoiodous acid when the iodide (I(-)) concentration is elevated in ASL.	Iodides	120-126	lactoperoxidase	Homo sapiens	64-67
24412532-2	2014	This study characterises for the first time the calcium-dependent chloride channels (CaCC) in the plasma membrane of primary human atrial cardiac fibroblasts by means of the iodide efflux and the patch clamp methods.	Iodides	174-180	chloride channel accessory 1	Homo sapiens	85-89
24338365-3	2014	Here, we used digital holographic microscopy (DHM) an interferometric technique to quantify in situ the transmembrane water fluxes during the activity of the epithelial chloride channel, CFTR, measured by patch-clamp and iodide efflux techniques.	Iodides	221-227	CF transmembrane conductance regulator	Homo sapiens	187-191
23636804-5	2014	NIS function was evaluated by iodide uptake assay.	Iodides	30-36	solute carrier family 5 member 5	Rattus norvegicus	0-3
24369144-6	2014	The in vivo iodide uptake by C81 cell xenografts in nude mice injected with an adenovirus carrying the hNIS gene linked to PSMA and the corresponding tumor volume fluctuation were assessed.	Iodides	12-18	folate hydrolase 1	Homo sapiens	123-127
24280616-6	2014	The formation of CHI3 was higher at 25 C than 5 C and 35 C. CHI3 formation showed an increase followed by a decrease trend with increasing ClO2 doses and iodide concentrations and the highest yields occurred at iodide to ClO2 molar ratios of 1-2. pH 8 resulted in the highest CHI3 formation.	Iodides	154-160	chitinase 1	Homo sapiens	17-21
24280616-6	2014	The formation of CHI3 was higher at 25 C than 5 C and 35 C. CHI3 formation showed an increase followed by a decrease trend with increasing ClO2 doses and iodide concentrations and the highest yields occurred at iodide to ClO2 molar ratios of 1-2. pH 8 resulted in the highest CHI3 formation.	Iodides	154-160	chitinase 1	Homo sapiens	60-64
24280616-6	2014	The formation of CHI3 was higher at 25 C than 5 C and 35 C. CHI3 formation showed an increase followed by a decrease trend with increasing ClO2 doses and iodide concentrations and the highest yields occurred at iodide to ClO2 molar ratios of 1-2. pH 8 resulted in the highest CHI3 formation.	Iodides	154-160	chitinase 1	Homo sapiens	60-64
24280616-6	2014	The formation of CHI3 was higher at 25 C than 5 C and 35 C. CHI3 formation showed an increase followed by a decrease trend with increasing ClO2 doses and iodide concentrations and the highest yields occurred at iodide to ClO2 molar ratios of 1-2. pH 8 resulted in the highest CHI3 formation.	Iodides	211-217	chitinase 1	Homo sapiens	17-21
24280616-6	2014	The formation of CHI3 was higher at 25 C than 5 C and 35 C. CHI3 formation showed an increase followed by a decrease trend with increasing ClO2 doses and iodide concentrations and the highest yields occurred at iodide to ClO2 molar ratios of 1-2. pH 8 resulted in the highest CHI3 formation.	Iodides	211-217	chitinase 1	Homo sapiens	60-64
24280616-6	2014	The formation of CHI3 was higher at 25 C than 5 C and 35 C. CHI3 formation showed an increase followed by a decrease trend with increasing ClO2 doses and iodide concentrations and the highest yields occurred at iodide to ClO2 molar ratios of 1-2. pH 8 resulted in the highest CHI3 formation.	Iodides	211-217	chitinase 1	Homo sapiens	60-64
24307546-1	2014	We describe an effective method for catalytic reduction of 1  alkyl sulfonates, and 1  and 2  iodides in the presence of a wide range of functional groups.	Iodides	94-101	WD repeat and HMG-box DNA binding protein 1	Homo sapiens	80-92
24231001-0	2014	The role of the IRE1 pathway in excessive iodide- and/or fluoride-induced apoptosis in Nthy-ori 3-1 cells in vitro.	Iodides	42-48	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	16-20
24231001-7	2014	Although these data do not manifest iodide could induce the IRE1 pathway, the cytotoxicity followed by exposure to fluoride alone or in combination with iodide may be related to IRE1 pathway-induced apoptosis.	Iodides	153-159	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	178-182
24369144-7	2014	Iodide accumulation was shown in different LNCaP cell lines after Ad.PSMApro-hNIS and Ad.CMV-hNIS infection, but not in different LNCaP cell lines after adenovirus.cytomegalovirus (Ad.CMV) infection.	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	77-81
24369144-7	2014	Iodide accumulation was shown in different LNCaP cell lines after Ad.PSMApro-hNIS and Ad.CMV-hNIS infection, but not in different LNCaP cell lines after adenovirus.cytomegalovirus (Ad.CMV) infection.	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	93-97
24369144-8	2014	At each time point, higher iodide uptake was shown in the C81 cells infected with Ad.PSMApro-hNIS than in the C33 cells (P &lt; 0.05).	Iodides	27-33	solute carrier family 5 member 5	Homo sapiens	93-97
23988430-1	2014	The sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated in iodide uptake into thyroid follicular cells.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	36-42
23988430-1	2014	The sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated in iodide uptake into thyroid follicular cells.	Iodides	91-97	solute carrier family 5 member 5	Homo sapiens	36-42
25309750-6	2014	The last part looks upon the characteristics of the active molecule produced by lactoperoxidase in the presence of thiocyanate and/or iodide with implication(s) on its antimicrobial activity.	Iodides	134-140	lactoperoxidase	Homo sapiens	80-95
24148240-4	2014	Moreover, OATP1B3 subtype of organic anion transporter peptides (OATPs) may play a dominant role in the transportation of IR-780 iodide into tumor cells, while cellular endocytosis, mitochondrial membrane potential and the ATP-binding cassette transporters did not show significant influence to its accumulation.	Iodides	129-135	solute carrier organic anion transporter family member 1B3	Homo sapiens	10-17
25177024-4	2014	In addition, iodotyrosine deiodinase, which is involved in iodide salvage by catalyzing deiodination of iodinated by-products of thyroid hormone production, was recently identified as a possible new target for disruption of thyroid hormone homeostasis by environmental halogenated chemicals.	Iodides	59-65	iodotyrosine deiodinase	Homo sapiens	13-36
25201006-3	2014	Anoctamin 1 (ANO1) is a calcium-activated chloride channel (CaCC), and this study aims to investigate its contribution to iodide fluxes in thyroid cells.	Iodides	122-128	anoctamin 1	Homo sapiens	0-11
25201006-3	2014	Anoctamin 1 (ANO1) is a calcium-activated chloride channel (CaCC), and this study aims to investigate its contribution to iodide fluxes in thyroid cells.	Iodides	122-128	anoctamin 1	Homo sapiens	13-17
25201006-6	2014	ATP induced a transient loss of iodide from FRTL-5 cells that was dependent on the mobilization of intracellular calcium, and was inhibited by CaCC/ANO1 inhibitors and siRNA against ANO1.	Iodides	32-38	anoctamin 1	Rattus norvegicus	182-186
25201006-7	2014	Calcium-activated iodide efflux was also observed in CHO cells over-expressing the Sodium Iodide Symporter (NIS) and ANO1.	Iodides	18-24	anoctamin-1	Cricetulus griseus	117-121
25201006-8	2014	CONCLUSION: ANO1 in thyrocytes functions as a calcium-activated channel mediating iodide efflux, and may contribute to the rapid delivery of iodide into the follicular lumen for the synthesis of thyroid hormones following activation by calcium-mobilizing stimuli.	Iodides	82-88	anoctamin 1	Homo sapiens	12-16
25201006-8	2014	CONCLUSION: ANO1 in thyrocytes functions as a calcium-activated channel mediating iodide efflux, and may contribute to the rapid delivery of iodide into the follicular lumen for the synthesis of thyroid hormones following activation by calcium-mobilizing stimuli.	Iodides	141-147	anoctamin 1	Homo sapiens	12-16
25484068-5	2014	In the tissue distribution study, radiolabeled anti-DLL4 (mixture of (125)Iodide and (111)Indium) was administered in the presence of increasing amounts of unlabeled anti-DLL4.	Iodides	74-80	delta like canonical Notch ligand 4	Mus musculus	52-56
23819433-2	2014	The aim of this study was to investigate the mechanism of AMPK modulation in iodide uptake.	Iodides	77-83	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	58-62
24239760-10	2014	Both methods were successfully applied to determining iodide in tap and river water samples.	Iodides	54-60	filamin B	Homo sapiens	64-67
24153409-2	2014	The role of both iodide and iodinated tyrosine derivatives is currently unknown in lower organisms, yet the presence of a key enzyme in iodide conservation, iodotyrosine deiodinase (IYD), is suggested by genomic data from a wide range of multicellular organisms as well as some bacteria.	Iodides	17-23	iodotyrosine deiodinase	Homo sapiens	182-185
24153409-2	2014	The role of both iodide and iodinated tyrosine derivatives is currently unknown in lower organisms, yet the presence of a key enzyme in iodide conservation, iodotyrosine deiodinase (IYD), is suggested by genomic data from a wide range of multicellular organisms as well as some bacteria.	Iodides	136-142	iodotyrosine deiodinase	Homo sapiens	157-180
24153409-2	2014	The role of both iodide and iodinated tyrosine derivatives is currently unknown in lower organisms, yet the presence of a key enzyme in iodide conservation, iodotyrosine deiodinase (IYD), is suggested by genomic data from a wide range of multicellular organisms as well as some bacteria.	Iodides	136-142	iodotyrosine deiodinase	Homo sapiens	182-185
23819433-3	2014	Furthermore, we wanted to investigate the potential of the AMPK inhibitor compound C as an enhancer of iodide uptake by thyrocytes.	Iodides	103-109	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	59-63
23819433-4	2014	METHODS: The in vitro and in vivo effects of AMPK modulation on sodium-iodide symporter (NIS) protein levels and iodide uptake were examined in follicular rat thyroid cell-line cells and C57Bl6/J mice.	Iodides	71-77	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	45-49
23819433-5	2014	Activation of AMPK by metformin resulted in a strong reduction of iodide uptake (up to sixfold with 5 mM metformin after 96 h) and NIS protein levels in vitro, whereas AMPK inhibition by compound C not only stimulated iodide uptake but also enhanced NIS protein levels both in vitro (up to sevenfold with 1 muM compound C after 96 h) and in vivo (1.5-fold after daily injections with 20 mg/kg for 4 days).	Iodides	66-72	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	14-18
23819433-5	2014	Activation of AMPK by metformin resulted in a strong reduction of iodide uptake (up to sixfold with 5 mM metformin after 96 h) and NIS protein levels in vitro, whereas AMPK inhibition by compound C not only stimulated iodide uptake but also enhanced NIS protein levels both in vitro (up to sevenfold with 1 muM compound C after 96 h) and in vivo (1.5-fold after daily injections with 20 mg/kg for 4 days).	Iodides	218-224	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	14-18
23819433-9	2014	These experiments show that AMPK exerts its effects on iodide uptake, at least partly, through the CRE element in the NIS promoter.	Iodides	55-61	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	28-32
23819433-13	2014	Overall, this suggests that the use of AMPK modulating compounds may be useful for the enhancement of iodide uptake by thyrocytes, which could be useful for the treatment of thyroid cancer patients with radioactive iodine.	Iodides	102-108	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	39-43
24783055-9	2013	CONCLUSIONS: Pregnancy-associated hormones, particularly oxytocin and hCG, have a role in promoting placental iodide uptake which may protect the fetus against iodine deficiency.	Iodides	110-116	oxytocin/neurophysin I prepropeptide	Homo sapiens	57-65
24783055-9	2013	CONCLUSIONS: Pregnancy-associated hormones, particularly oxytocin and hCG, have a role in promoting placental iodide uptake which may protect the fetus against iodine deficiency.	Iodides	110-116	hypertrichosis 2 (generalised, congenital)	Homo sapiens	70-73
23757361-4	2013	Calcium channel activity was recorded using Fluo-4 probe and CFTR activity was measured by iodide efflux technique in the presence of CFTR activators (forskolin, genistein) and VX-770, CFTR inhibitor (GPinh5a) and TRPC non-selective modulators (OAG, SKF96365).	Iodides	91-97	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	61-65
24095759-6	2013	Compound 5b (ethyl-dimethyl-{3-[methyl-(tetradecane-1-sulfonyl)-amino]-propyl}-ammonium; iodide) was the most promising anticancer agent in the series, based upon the potency of growth inhibition and RhoB promotion.	Iodides	89-95	ras homolog family member B	Homo sapiens	200-204
24193032-1	2013	We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of combined radiovirotherapy after systemic delivery of the theranostic sodium iodide symporter (NIS) gene using a dendrimer-coated adenovirus.	Iodides	41-47	solute carrier family 5 member 5	Homo sapiens	177-180
23883148-4	2013	The prohormone thyroxine (T4) is synthesized on thyroglobulin by thyroid peroxidase (TPO), a heme enzyme that uses iodide and hydrogen peroxide to perform iodination and phenolic coupling reactions.	Iodides	115-121	thyroid peroxidase	Homo sapiens	85-88
23903663-2	2013	The simple push-pull DPP-CN2 gives a promising photoconversion efficiency (PCE) of 0.07% with the iodide/triiodide electrolyte while the PCE of the dyad reaches 0.18% with a cobalt complex as a redox shuttle.	Iodides	98-105	carnosine dipeptidase 2	Homo sapiens	25-28
23991650-1	2013	INTRODUCTION: Thyroid hormone (TH) metabolism is mediated by deiodinases, a family of thioredoxin fold-containing enzymes that remove iodide from thyroxine and its derivatives.	Iodides	134-140	thioredoxin	Homo sapiens	86-97
24070486-1	2013	In this contribution, we demonstrated a novel colorimetric method for highly sensitive and accurate detection of iodide using citrate-stabilized silver triangular nanoplates (silver TNPs).	Iodides	113-119	C1GALT1 specific chaperone 1	Homo sapiens	182-186
24070486-2	2013	Very lower concentration of iodide can induce an appreciable color change of silver TNPs solution from blue to yellow by fusing of silver TNPs to nanoparticles, as confirmed by UV-vis absorption spectroscopy and transmission electron microscopy (TEM).	Iodides	28-34	C1GALT1 specific chaperone 1	Homo sapiens	84-88
24070486-2	2013	Very lower concentration of iodide can induce an appreciable color change of silver TNPs solution from blue to yellow by fusing of silver TNPs to nanoparticles, as confirmed by UV-vis absorption spectroscopy and transmission electron microscopy (TEM).	Iodides	28-34	C1GALT1 specific chaperone 1	Homo sapiens	138-142
24075720-6	2013	This method was successfully applied to the determination of iodide, iodate and organo-iodine in a variety of water samples, including tap water, seawater, urine and wastewater.	Iodides	61-67	nuclear RNA export factor 1	Homo sapiens	135-138
24052075-1	2013	Thyroid iodide accumulation via the sodium/iodide symporter (NIS; SLC5A5) has been the basis for the longtime use of radio-iodide in the diagnosis and treatment of thyroid cancers.	Iodides	8-14	solute carrier family 5 member 5	Homo sapiens	61-64
24052075-1	2013	Thyroid iodide accumulation via the sodium/iodide symporter (NIS; SLC5A5) has been the basis for the longtime use of radio-iodide in the diagnosis and treatment of thyroid cancers.	Iodides	8-14	solute carrier family 5 member 5	Homo sapiens	66-72
23857380-2	2013	Na(+)/I(-) symporter (NIS) is a plasma membrane glycoprotein, which mediates active iodide uptake.	Iodides	84-90	solute carrier family 5 member 5	Homo sapiens	0-20
23471296-7	2013	Iodide has the strongest inhibitory effect on TRPM7 at physiological [Mg(2+)]i.	Iodides	0-6	transient receptor potential cation channel subfamily M member 7	Homo sapiens	46-51
23471296-8	2013	Iodide also inhibits endogenous TRPM7-like currents as assessed in MCF-7 breast cancer cells, where upregulation of SLC5A5 sodium-iodide symporter enhances iodide uptake and inhibits cell proliferation.	Iodides	0-6	transient receptor potential cation channel subfamily M member 7	Homo sapiens	32-37
23471296-8	2013	Iodide also inhibits endogenous TRPM7-like currents as assessed in MCF-7 breast cancer cells, where upregulation of SLC5A5 sodium-iodide symporter enhances iodide uptake and inhibits cell proliferation.	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	116-122
23471296-8	2013	Iodide also inhibits endogenous TRPM7-like currents as assessed in MCF-7 breast cancer cells, where upregulation of SLC5A5 sodium-iodide symporter enhances iodide uptake and inhibits cell proliferation.	Iodides	130-136	transient receptor potential cation channel subfamily M member 7	Homo sapiens	32-37
23471296-8	2013	Iodide also inhibits endogenous TRPM7-like currents as assessed in MCF-7 breast cancer cells, where upregulation of SLC5A5 sodium-iodide symporter enhances iodide uptake and inhibits cell proliferation.	Iodides	130-136	solute carrier family 5 member 5	Homo sapiens	116-122
23471296-9	2013	These results indicate that chloride could be an important factor in modulating TRPM7 during osmotic stress and implicate TRPM7 as a possible molecular mechanism contributing to the anti-proliferative characteristics of intracellular iodide accumulation in cancer cells.	Iodides	234-240	transient receptor potential cation channel subfamily M member 7	Homo sapiens	80-85
23737077-7	2013	The inhibitory activity of these selones towards LPO-catalyzed oxidation/iodination reactions is due to their ability to decrease the concentrations of the co-substrates (H2O2 and I2), either by catalytically reducing H2O2 (anti-oxidant activity) or by forming stable charge-transfer complexes with oxidized iodide species.	Iodides	308-314	lactoperoxidase	Homo sapiens	49-52
23471296-9	2013	These results indicate that chloride could be an important factor in modulating TRPM7 during osmotic stress and implicate TRPM7 as a possible molecular mechanism contributing to the anti-proliferative characteristics of intracellular iodide accumulation in cancer cells.	Iodides	234-240	transient receptor potential cation channel subfamily M member 7	Homo sapiens	122-127
23018590-2	2013	Iodide (I(-)) is transported into thyroid cells via a Na(+)/I(-) symporter (NIS), which is electrogenic and thus sensitive to alterations in membrane potential (V(m)).	Iodides	0-6	solute carrier family 5 member 5	Rattus norvegicus	54-74
23984517-2	2013	CFTR-mediated iodide influx assay and patch-clamp tests were done on FRT cells stably co-transfected with human CFTR and EYFP/H148Q.	Iodides	14-20	CF transmembrane conductance regulator	Homo sapiens	0-4
25960948-4	2013	The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA.	Iodides	74-80	solute carrier family 26 member 4	Homo sapiens	38-45
25960948-5	2013	The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA.	Iodides	76-82	solute carrier family 26 member 4	Homo sapiens	42-49
23542164-1	2013	The uptake of iodide into the thyroid, an essential step in thyroid hormone synthesis, is an active process mediated by the sodium-iodide symporter (NIS).	Iodides	14-20	solute carrier family 5 member 5	Rattus norvegicus	149-152
23542164-7	2013	Sterol-mediated inhibition of SREBP maturation and/or RNA interference-mediated knockdown of SREBPs reduced expression of NIS and NIS-specific iodide uptake in FRTL-5 cells.	Iodides	143-149	solute carrier family 5 member 5	Rattus norvegicus	130-133
23618770-2	2013	This study aimed to investigate iodide uptake and the expressions of thyroid-specific molecules after the transfection of human thyrotropin receptor (hTSHR) gene in poorly differentiated follicular thyroid cancer cell line (FTC-133).	Iodides	32-38	thyroid stimulating hormone receptor	Homo sapiens	128-148
23447550-9	2013	Complex 4 reacts with LiI to give the diiodido derivative mer-[I2(PMe3)3Re Ge-C6H3-2,6-Trip2] (5), which undergoes a metathetical iodide/hydride exchange with Na(BEt3H) to give the dihydrido germylidyne complex mer-[H2(PMe3)3Re Ge-C6H3-2,6-Trip2] (6).	Iodides	130-136	mediator complex subunit 1	Homo sapiens	87-92
23447550-9	2013	Complex 4 reacts with LiI to give the diiodido derivative mer-[I2(PMe3)3Re Ge-C6H3-2,6-Trip2] (5), which undergoes a metathetical iodide/hydride exchange with Na(BEt3H) to give the dihydrido germylidyne complex mer-[H2(PMe3)3Re Ge-C6H3-2,6-Trip2] (6).	Iodides	130-136	mediator complex subunit 1	Homo sapiens	240-245
23441638-1	2013	BACKGROUND: Physiologic iodide-uptake, mediated by the sodium/iodide symporter (NIS), in the salivary gland confers its susceptibility to radioactive iodine-induced damage following (131)I treatment of thyroid cancer.	Iodides	24-30	solute carrier family 5 member 5	Homo sapiens	80-83
23678037-9	2013	Of direct clinical importance to the treatment of thyroid cancer, PP1 stimulates iodide uptake by transfected NIS in TPC1 thyroid carcinoma cells and entirely overcomes PBF repression of iodide uptake in human primary thyroid cells.	Iodides	81-87	inorganic pyrophosphatase 1	Homo sapiens	66-69
23678037-9	2013	Of direct clinical importance to the treatment of thyroid cancer, PP1 stimulates iodide uptake by transfected NIS in TPC1 thyroid carcinoma cells and entirely overcomes PBF repression of iodide uptake in human primary thyroid cells.	Iodides	81-87	two pore segment channel 1	Homo sapiens	117-121
23678037-9	2013	Of direct clinical importance to the treatment of thyroid cancer, PP1 stimulates iodide uptake by transfected NIS in TPC1 thyroid carcinoma cells and entirely overcomes PBF repression of iodide uptake in human primary thyroid cells.	Iodides	187-193	inorganic pyrophosphatase 1	Homo sapiens	66-69
23678037-9	2013	Of direct clinical importance to the treatment of thyroid cancer, PP1 stimulates iodide uptake by transfected NIS in TPC1 thyroid carcinoma cells and entirely overcomes PBF repression of iodide uptake in human primary thyroid cells.	Iodides	187-193	PTTG1 interacting protein	Homo sapiens	169-172
23463616-2	2013	CFTR-dependent iodide transport measured by fluorescent quenching of ectopically expressed halide-sensitive yellow fluorescent protein (YFP) is widely being used to study CFTR function by microscopy or plate readers.	Iodides	15-21	CF transmembrane conductance regulator	Homo sapiens	0-4
23463616-2	2013	CFTR-dependent iodide transport measured by fluorescent quenching of ectopically expressed halide-sensitive yellow fluorescent protein (YFP) is widely being used to study CFTR function by microscopy or plate readers.	Iodides	15-21	CF transmembrane conductance regulator	Homo sapiens	171-175
23444413-0	2013	Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition.	Iodides	101-107	thyroglobulin	Homo sapiens	0-13
23351431-5	2013	Complete conversion of iodide to iodate while minimizing the bromate formation to below the guideline value of 10 mug L-1 was achieved for a wide range of ozone doses in five raw waters with DOC and bromide concentrations of 1.1-20 mg L-1 and 170-940 mug L-1, respectively.	Iodides	23-29	immunoglobulin kappa variable 1-16	Homo sapiens	118-121
23351431-5	2013	Complete conversion of iodide to iodate while minimizing the bromate formation to below the guideline value of 10 mug L-1 was achieved for a wide range of ozone doses in five raw waters with DOC and bromide concentrations of 1.1-20 mg L-1 and 170-940 mug L-1, respectively.	Iodides	23-29	immunoglobulin kappa variable 1-16	Homo sapiens	235-258
23393644-6	2013	The quenched fluorescence and enhanced surface plasmon resonance absorbance were found to be proportional to the iodide concentration over the range of 0.8-60 and 1.2-50 muM with a detection limit (3sigma) of 118 nM and 215 nM, respectively.	Iodides	113-119	latexin	Homo sapiens	170-173
23018590-11	2013	The uptake of iodide was enhanced and the resting V(m) was more depolarised in TRPC2 knock-down cells.	Iodides	14-20	transient receptor potential cation channel subfamily C member 2	Rattus norvegicus	79-84
23018590-12	2013	We suggest that the interplay between TRPC2 and ANO1 may have dual effects on iodide transport, modulating I(-) release via ANO channels and I(-) uptake via the V(m) sensitive NIS.	Iodides	78-84	transient receptor potential cation channel subfamily C member 2	Rattus norvegicus	38-43
23018590-12	2013	We suggest that the interplay between TRPC2 and ANO1 may have dual effects on iodide transport, modulating I(-) release via ANO channels and I(-) uptake via the V(m) sensitive NIS.	Iodides	78-84	anoctamin 1	Rattus norvegicus	48-52
23295212-3	2013	In solutions containing 0.2M KI, complexation with HSA results in a strongly increased NPX fluorescence intensity and a decreased NPX phosphorescence intensity due to the inhibition of the collisional interaction with the heavy atom iodide.	Iodides	233-239	albumin	Homo sapiens	51-54
23439081-3	2013	This latter feature maintains a Ru(III)/Ru(II) redox couple more positive than 0.8 V versus NHE, thereby accommodating regeneration of the oxidized dye by an iodide-based redox mediator.	Iodides	158-164	solute carrier family 9 member C1	Homo sapiens	92-95
23404134-11	2013	Furthermore, increased nutritional iodide could ensure a better use of H2O2 provided by DUOX1.	Iodides	35-41	dual oxidase 1	Homo sapiens	88-93
23360087-2	2013	The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes.	Iodides	235-241	NK2 homeobox 1	Mus musculus	51-57
23360087-2	2013	The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes.	Iodides	235-241	transcription termination factor, RNA polymerase I	Mus musculus	75-80
23360087-2	2013	The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes.	Iodides	235-241	paired box 8	Mus musculus	86-103
23360087-2	2013	The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes.	Iodides	235-241	paired box 8	Mus musculus	105-109
23360087-2	2013	The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes.	Iodides	235-241	thyroid stimulating hormone receptor	Mus musculus	287-291
23360087-2	2013	The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes.	Iodides	235-241	thyroglobulin	Mus musculus	294-307
23360087-2	2013	The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes.	Iodides	235-241	thyroglobulin	Mus musculus	309-311
23360087-2	2013	The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes.	Iodides	235-241	thyroid peroxidase	Mus musculus	318-336
23360087-2	2013	The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes.	Iodides	235-241	thyroid peroxidase	Mus musculus	338-341
23391999-0	2013	Chemiluminescence assay for the sensitive detection of iodide based on extracting Hg2+ from a T-Hg(2+)-T complex.	Iodides	55-61	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	82-85
23404856-1	2013	The Na(+)/I(-) symporter (NIS (SLC5A5)) is a transmembrane glycoprotein that mediates active iodide uptake into thyroid follicular cells.	Iodides	93-99	solute carrier family 5 member 5	Homo sapiens	4-24
23404856-1	2013	The Na(+)/I(-) symporter (NIS (SLC5A5)) is a transmembrane glycoprotein that mediates active iodide uptake into thyroid follicular cells.	Iodides	93-99	solute carrier family 5 member 5	Homo sapiens	31-37
23420532-8	2013	The clonogenic assay indicated that, following exposure to 500 muCi of (131)I-iodide for 12 h, &gt;90% of cells transfected with the hNIS gene were killed.	Iodides	77-84	solute carrier family 5 member 5	Homo sapiens	133-137
23410159-4	2013	The temperature-induced changes induced on LF conformation were analyzed through intrinsic and ANS fluorescence parameters (intensity, maximum position, and parameter A value), the phase diagram method, and quenching experiments using acrylamide and iodide.	Iodides	250-256	lactotransferrin	Bos taurus	43-45
23384053-4	2013	This led to the postulation of the two iodide process (TIP) [(D(+)   I(-)) + I(-)   (D   I(2)(-))   D(0) + I(2)(-))] for a sufficiently high reducing power, but TIP is not consistent with either the recent experimental data suggesting the first-order kinetics or recent time-resolved spectroscopic measurements.	Iodides	39-45	TOR signaling pathway regulator	Homo sapiens	55-58
23384053-4	2013	This led to the postulation of the two iodide process (TIP) [(D(+)   I(-)) + I(-)   (D   I(2)(-))   D(0) + I(2)(-))] for a sufficiently high reducing power, but TIP is not consistent with either the recent experimental data suggesting the first-order kinetics or recent time-resolved spectroscopic measurements.	Iodides	39-45	TOR signaling pathway regulator	Homo sapiens	161-164
23322815-1	2013	CONTEXT: Pendrin is a transmembrane protein located at the apical end of the thyrocyte in which it mediates the efflux of iodide through the thyroid follicular cell.	Iodides	122-128	solute carrier family 26 member 4	Homo sapiens	9-16
23420532-11	2013	The experiments demonstrated that effective (131)I therapy was achieved in the malignant glioma cell lines following the induction of tumor-specific iodide uptake activity by GFAP promoter-directed hNIS gene expression in vitro and in vivo.	Iodides	149-155	glial fibrillary acidic protein	Mus musculus	175-179
23420532-11	2013	The experiments demonstrated that effective (131)I therapy was achieved in the malignant glioma cell lines following the induction of tumor-specific iodide uptake activity by GFAP promoter-directed hNIS gene expression in vitro and in vivo.	Iodides	149-155	solute carrier family 5 member 5	Homo sapiens	198-202
23559853-8	2013	Intrinsic tryptophan fluorescence studies revealed moderate shifts in the emission maxima and increased quenching by iodide ion of mutant TGFBIp, suggesting a different conformation than WT protein.	Iodides	117-123	transforming growth factor beta induced	Homo sapiens	138-144
23935625-3	2013	Spectrophotometric methods entail addition of a known excess of NBS in acid medium followed by the determination of residual NBS by its reaction with excess iodide, and the liberated iodine (I3 (-)) is either measured at 370 nm (method B) or liberated iodine is reacted with starch followed by the measurement of the blue colored starch-iodine complex at 570 nm (method C).	Iodides	157-163	nibrin	Homo sapiens	125-128
23117572-4	2013	Expression of Na(+)/I(-) symporter (NIS (SLC5A5)), the glycoprotein responsible for iodide transport, has been demonstrated in normal testicular tissue.	Iodides	84-90	solute carrier family 5 member 5	Homo sapiens	14-34
23117572-4	2013	Expression of Na(+)/I(-) symporter (NIS (SLC5A5)), the glycoprotein responsible for iodide transport, has been demonstrated in normal testicular tissue.	Iodides	84-90	solute carrier family 5 member 5	Homo sapiens	41-47
23200355-3	2013	A lower detection limit of about 20 muM was obtained for iodide and 10 muM for iodine.	Iodides	57-63	latexin	Homo sapiens	36-39
24429827-1	2013	BACKGROUND: The anion exchanger pendrin (SLC26A4) is required for proper development of the inner ear, and contributes to iodide organification in thyroid glands as well as anion transport in various epithelia, such as airways and renal tubules.	Iodides	122-128	solute carrier family 26, member 4	Mus musculus	32-39
24429827-1	2013	BACKGROUND: The anion exchanger pendrin (SLC26A4) is required for proper development of the inner ear, and contributes to iodide organification in thyroid glands as well as anion transport in various epithelia, such as airways and renal tubules.	Iodides	122-128	solute carrier family 26, member 4	Mus musculus	41-48
23037808-0	2012	A steep radioiodine dose response scalable to humans in sodium-iodide symporter (NIS)-mediated radiovirotherapy for prostate cancer.	Iodides	63-69	solute carrier family 5 member 5	Homo sapiens	81-84
23089227-10	2012	Phagosomal uptake of iodide and protein iodination were significantly blocked by chloride channel inhibitors, including CFTRinh-172 and NPPB.	Iodides	21-27	natriuretic peptide B	Homo sapiens	136-140
23037808-1	2012	The sodium-iodide symporter (NIS) directs the uptake and concentration of iodide in thyroid cells.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
22995901-9	2012	ALA increased phosphorylation of CREB and nuclear translocation of pCREB, and co-treatment of ALA and trichostatin A increased iodide uptake by three folds in TPC-1 cells.	Iodides	127-133	two pore segment channel 1	Homo sapiens	159-164
23181221-6	2012	The sodium-iodide symporter (NIS) is responsible for the ability of the thyroid gland to transport and concentrate iodide.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
23006481-0	2012	Dietary iodide controls its own absorption through post-transcriptional regulation of the intestinal Na+/I- symporter.	Iodides	8-14	solute carrier family 5 member 5	Rattus norvegicus	101-117
23006481-7	2012	Iodide induced rapid intracellular recruitment of plasma membrane NIS molecules and NIS protein degradation.	Iodides	0-6	solute carrier family 5 member 5	Rattus norvegicus	66-69
23006481-7	2012	Iodide induced rapid intracellular recruitment of plasma membrane NIS molecules and NIS protein degradation.	Iodides	0-6	solute carrier family 5 member 5	Rattus norvegicus	84-87
22962269-3	2012	In this study, we investigated the functional role in tumor progression of the sodium/iodide symporter (NIS; aka SLC5A5), which is upregulated and mislocalized in many human carcinomas.	Iodides	86-92	solute carrier family 5 member 5	Homo sapiens	113-119
23055533-12	2012	Using real-time quantitative PCR for the quantification of gene expression, we additionally noticed upregulation of the tumor necrosis factor-related apoptosis-inducing ligand and the thyroid-specific transcription factors Pax8 and TTF-1, leading to expression of the thyroid-specific target genes thyroglobulin, sodium iodide symporter, thyroperoxidase, and thyroid-stimulating hormone receptor and to a moderate accumulation of iodide in ATC cells.	Iodides	320-326	paired box 8	Homo sapiens	223-227
23055533-12	2012	Using real-time quantitative PCR for the quantification of gene expression, we additionally noticed upregulation of the tumor necrosis factor-related apoptosis-inducing ligand and the thyroid-specific transcription factors Pax8 and TTF-1, leading to expression of the thyroid-specific target genes thyroglobulin, sodium iodide symporter, thyroperoxidase, and thyroid-stimulating hormone receptor and to a moderate accumulation of iodide in ATC cells.	Iodides	320-326	transcription termination factor 1	Homo sapiens	232-237
22874065-2	2012	Tg, which is stored in the follicular space, is also a potent negative feedback regulator of follicular function, and this is achieved by suppressing mRNA levels of thyroid-specific genes such as the sodium/iodide symporter (Slc5a5), Tg, and thyroid peroxidase.	Iodides	207-213	thyroglobulin	Rattus norvegicus	0-2
22865369-8	2012	Because iodide is mainly taken up from the diet in the intestine and the tadpole stops feeding during metamorphosis when the intestine is being remodeled, our findings suggest that IYD transcription is activated by liganded TH receptors early during intestinal remodeling to ensure efficient iodine recycling at the climax of metamorphosis when highest levels of TH are needed for the proper transformations of different organs.	Iodides	8-14	iodotyrosine deiodinase	Xenopus tropicalis	181-184
22874065-2	2012	Tg, which is stored in the follicular space, is also a potent negative feedback regulator of follicular function, and this is achieved by suppressing mRNA levels of thyroid-specific genes such as the sodium/iodide symporter (Slc5a5), Tg, and thyroid peroxidase.	Iodides	207-213	solute carrier family 5 member 5	Rattus norvegicus	225-231
22953992-3	2012	Recently, our group showed that AMP-activated protein kinase (AMPK) plays a pivotal role in the rat thyroid gland, downregulating iodide uptake by thyroid cells even in the presence of its main stimulator thyrotropin (TSH).	Iodides	130-136	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	32-60
22953992-3	2012	Recently, our group showed that AMP-activated protein kinase (AMPK) plays a pivotal role in the rat thyroid gland, downregulating iodide uptake by thyroid cells even in the presence of its main stimulator thyrotropin (TSH).	Iodides	130-136	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	62-66
22953992-4	2012	Since AMPK increases glucose uptake in different tissues, and taken into consideration that in pathophysiological conditions such as thyroid cancer a negative correlation between iodide and glucose uptake occurs, we hypothesized that AMPK might modulate glucose uptake in thyroid cells.	Iodides	179-185	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	6-10
22953992-4	2012	Since AMPK increases glucose uptake in different tissues, and taken into consideration that in pathophysiological conditions such as thyroid cancer a negative correlation between iodide and glucose uptake occurs, we hypothesized that AMPK might modulate glucose uptake in thyroid cells.	Iodides	179-185	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	234-238
22874065-13	2012	These results suggest that Tg is a strong suppressor of the expression and the activity of DUOX2/DUOXA2, thereby regulating iodide organification and hormone synthesis in the thyroid.	Iodides	124-130	thyroglobulin	Rattus norvegicus	27-29
22874065-13	2012	These results suggest that Tg is a strong suppressor of the expression and the activity of DUOX2/DUOXA2, thereby regulating iodide organification and hormone synthesis in the thyroid.	Iodides	124-130	dual oxidase 2	Rattus norvegicus	91-96
22874065-13	2012	These results suggest that Tg is a strong suppressor of the expression and the activity of DUOX2/DUOXA2, thereby regulating iodide organification and hormone synthesis in the thyroid.	Iodides	124-130	dual oxidase maturation factor 2	Rattus norvegicus	97-103
22535767-2	2012	The sodium iodide symporter (NIS) delivers iodide from the bloodstream into the thyroid, and after TH biosynthesis, monocarboxylate transporter 8 (MCT8) mediates TH secretion from the thyroid gland.	Iodides	11-17	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	116-145
22703526-4	2012	The syn iodo-imidazoliophane isomer forms novel dimeric isostructural XB complexes of 2:2 stoichiometry with bromide and iodide anions in the solid state.	Iodides	121-127	synemin	Homo sapiens	4-7
22703526-6	2012	(1)H NMR and fluorescence spectroscopic titration experiments with a variety of anions in the competitive CD(3)OD/D(2)O (9:1) aqueous solvent mixture demonstrated the bromo- and syn iodo-imidazoliophane XB receptors to bind selectively iodide and bromide respectively, and sense these halide anions exclusively via a fluorescence response.	Iodides	236-242	synemin	Homo sapiens	178-181
22703526-8	2012	Computational DFT and molecular dynamics simulations corroborate the experimental observations that bromo- and syn iodo-imidazoliophane XB receptors form stable cooperative convergent XB associations with bromide and iodide.	Iodides	217-223	synemin	Homo sapiens	111-114
22750642-1	2012	Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in thyroid and lactating breast.	Iodides	25-31	solute carrier family 5 member 5	Homo sapiens	43-46
22750642-8	2012	Iodide uptake in mammalian cells is dependent on the level of NIS gene expression, but also successful translocation of NIS to the cell membrane and correct insertion.	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	62-65
22750642-8	2012	Iodide uptake in mammalian cells is dependent on the level of NIS gene expression, but also successful translocation of NIS to the cell membrane and correct insertion.	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	120-123
22535767-2	2012	The sodium iodide symporter (NIS) delivers iodide from the bloodstream into the thyroid, and after TH biosynthesis, monocarboxylate transporter 8 (MCT8) mediates TH secretion from the thyroid gland.	Iodides	11-17	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	147-151
22355179-1	2012	The selective increase of Na(+)/I(-) symporter (NIS)-mediated active iodide uptake in thyroid cells allows the use of radioiodine I(131) for diagnosis and targeted treatment of thyroid cancers.	Iodides	69-75	solute carrier family 5 member 5	Homo sapiens	26-46
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	transcription termination factor 1	Homo sapiens	53-59
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	paired box 8	Homo sapiens	64-69
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	thyroglobulin	Homo sapiens	218-220
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	thyroid peroxidase	Homo sapiens	223-238
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	thyroid peroxidase	Homo sapiens	240-243
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	transcription termination factor 1	Homo sapiens	450-455
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	paired box 8	Homo sapiens	460-465
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	transcription termination factor 1	Homo sapiens	53-59
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	paired box 8	Homo sapiens	64-69
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	thyroglobulin	Homo sapiens	218-220
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	thyroid peroxidase	Homo sapiens	223-238
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	thyroid peroxidase	Homo sapiens	240-243
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	transcription termination factor 1	Homo sapiens	450-455
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	paired box 8	Homo sapiens	460-465
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	125-131	transcription termination factor 1	Homo sapiens	53-59
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	125-131	paired box 8	Homo sapiens	64-69
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	125-131	thyroglobulin	Homo sapiens	203-216
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	125-131	thyroglobulin	Homo sapiens	218-220
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	125-131	thyroid peroxidase	Homo sapiens	223-238
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	125-131	thyroid peroxidase	Homo sapiens	240-243
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	125-131	transcription termination factor 1	Homo sapiens	450-455
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	125-131	paired box 8	Homo sapiens	460-465
22355179-5	2012	In comparison, Akt inhibition by Akti-1/2 did not increase NIS protein levels, yet markedly increased NIS-mediated RAIU by decreasing iodide efflux rate and increasing iodide transport rate and iodide affinity of NIS.	Iodides	134-140	AKT serine/threonine kinase 1	Homo sapiens	15-18
22355179-5	2012	In comparison, Akt inhibition by Akti-1/2 did not increase NIS protein levels, yet markedly increased NIS-mediated RAIU by decreasing iodide efflux rate and increasing iodide transport rate and iodide affinity of NIS.	Iodides	168-174	AKT serine/threonine kinase 1	Homo sapiens	15-18
22355179-5	2012	In comparison, Akt inhibition by Akti-1/2 did not increase NIS protein levels, yet markedly increased NIS-mediated RAIU by decreasing iodide efflux rate and increasing iodide transport rate and iodide affinity of NIS.	Iodides	168-174	AKT serine/threonine kinase 1	Homo sapiens	15-18
22455542-4	2012	H(2)O(2)-dependent iodide oxidation increased exponentially from 8.4 to 825.9 muM with decreasing pH from 9 to 4.	Iodides	19-25	latexin	Homo sapiens	78-81
22038833-9	2012	Ablation of K8 expression by siRNA in F508del-expressing HeLa cells led to the recovery of CFTR-dependent iodide efflux.	Iodides	106-112	CF transmembrane conductance regulator	Homo sapiens	91-95
22362924-4	2012	Using iodide efflux as a biochemical marker of CFTR activity and short circuit current (I(sc)) recordings, we found that the H2O2-stimulated efflux was abolished by cyclooxygenase-1 inhibition and potentially also involves microsomal prostaglandin E synthase-1 activity, implicating a role for PGE2 production.	Iodides	6-12	CF transmembrane conductance regulator	Homo sapiens	47-51
22362924-4	2012	Using iodide efflux as a biochemical marker of CFTR activity and short circuit current (I(sc)) recordings, we found that the H2O2-stimulated efflux was abolished by cyclooxygenase-1 inhibition and potentially also involves microsomal prostaglandin E synthase-1 activity, implicating a role for PGE2 production.	Iodides	6-12	prostaglandin-endoperoxide synthase 1	Homo sapiens	165-181
22362924-4	2012	Using iodide efflux as a biochemical marker of CFTR activity and short circuit current (I(sc)) recordings, we found that the H2O2-stimulated efflux was abolished by cyclooxygenase-1 inhibition and potentially also involves microsomal prostaglandin E synthase-1 activity, implicating a role for PGE2 production.	Iodides	6-12	prostaglandin E synthase	Homo sapiens	223-260
22227235-7	2012	We conclude that autocrine VEGF may modulate thyroid function and that VEGFR inhibition increases iodide uptake and decreases PA production through regulation of p42/44 MAPK phosphorylation.	Iodides	98-104	kinase insert domain receptor	Homo sapiens	71-76
22307006-6	2012	Genes involved in thyroid development (Pax8 and Nkx2.1) and synthesis (sodium/iodide symporter, NIS, thyroglobulin, TG) were also transcriptionally up-regulated.	Iodides	78-84	paired box 8	Danio rerio	39-43
22307006-6	2012	Genes involved in thyroid development (Pax8 and Nkx2.1) and synthesis (sodium/iodide symporter, NIS, thyroglobulin, TG) were also transcriptionally up-regulated.	Iodides	78-84	NK2 homeobox 4b	Danio rerio	48-54
21833035-2	2012	Promoting iodide accumulation in tumor cells by re-expression of Pax-8 provides a possible strategy for radioiodine therapy of tumor.	Iodides	10-16	paired box 8	Homo sapiens	65-70
21833035-6	2012	Iodide uptake in thyroid carcinoma cells was reactivated by Pax-8 (increasing 3.3-fold in K1 cells and 5.7-fold in F133 cells).	Iodides	0-6	paired box 8	Homo sapiens	60-65
21833035-7	2012	Moreover, Pax-8 promoted iodide organification and the retention time of iodine in Pax-8-expressing cells apparently prolonged in vitro and in vivo (P&lt;0.05).	Iodides	25-31	paired box 8	Homo sapiens	10-15
21833035-10	2012	These results indicate that Pax-8 can promote iodide uptake, and specifically prolong the retention time of iodide in thyroid cancer in vitro and in vivo by promoting the expression of TPO and Tg proteins.	Iodides	46-52	paired box 8	Homo sapiens	28-33
21833035-10	2012	These results indicate that Pax-8 can promote iodide uptake, and specifically prolong the retention time of iodide in thyroid cancer in vitro and in vivo by promoting the expression of TPO and Tg proteins.	Iodides	108-114	paired box 8	Homo sapiens	28-33
22178794-3	2012	This study attempted to investigate whether iodide administration affects SLC26A4 mRNA expression in rat thyroid and in PCCl3 cells.	Iodides	44-50	solute carrier family 26 member 4	Rattus norvegicus	74-81
22178794-6	2012	Iodide administration significantly increased SLC26A4 mRNA content in both models.	Iodides	0-6	solute carrier family 26 member 4	Rattus norvegicus	46-53
22178794-8	2012	These data show that intracellular iodide rapidly upregulates SLC26A4 mRNA expression.	Iodides	35-41	solute carrier family 26 member 4	Rattus norvegicus	62-69
22301785-5	2012	The DUOX1/DUOXA1 system may account for residual iodide organification in patients with loss of DUOX2, but its physiological function is less clear.	Iodides	49-55	dual oxidase 1	Homo sapiens	4-9
22301785-5	2012	The DUOX1/DUOXA1 system may account for residual iodide organification in patients with loss of DUOX2, but its physiological function is less clear.	Iodides	49-55	dual oxidase maturation factor 1	Homo sapiens	10-16
22301785-5	2012	The DUOX1/DUOXA1 system may account for residual iodide organification in patients with loss of DUOX2, but its physiological function is less clear.	Iodides	49-55	dual oxidase 2	Homo sapiens	96-101
22001309-0	2012	New insights about the posttranscriptional mechanisms triggered by iodide excess on sodium/iodide symporter (NIS) expression in PCCl3 cells.	Iodides	67-73	solute carrier family 5 member 5	Rattus norvegicus	109-112
22001309-0	2012	New insights about the posttranscriptional mechanisms triggered by iodide excess on sodium/iodide symporter (NIS) expression in PCCl3 cells.	Iodides	91-97	solute carrier family 5 member 5	Rattus norvegicus	109-112
22001309-1	2012	Iodide excess acutely downregulates NIS mRNA expression, as already demonstrated.	Iodides	0-6	solute carrier family 5 member 5	Rattus norvegicus	36-39
22001309-2	2012	PCCl3 cells treated or not with NaI, NaI+NaClO(4) or NaI+Methimazole, for 30 min to 24 h, were used to further explore how iodide reduces NIS gene expression.	Iodides	123-129	solute carrier family 5 member 5	Rattus norvegicus	138-141
22001309-4	2012	NIS mRNA decay rate was evaluated in actinomycin-D-treated cells, incubated with or without NaI for 0-6 h. Iodide treatment caused a reduction in NIS mRNA expression, half-life, poly(A) tail length, recruitment to ribosomes, as well as NIS protein expression.	Iodides	107-113	solute carrier family 5 member 5	Rattus norvegicus	0-3
22001309-4	2012	NIS mRNA decay rate was evaluated in actinomycin-D-treated cells, incubated with or without NaI for 0-6 h. Iodide treatment caused a reduction in NIS mRNA expression, half-life, poly(A) tail length, recruitment to ribosomes, as well as NIS protein expression.	Iodides	107-113	solute carrier family 5 member 5	Rattus norvegicus	146-149
22001309-4	2012	NIS mRNA decay rate was evaluated in actinomycin-D-treated cells, incubated with or without NaI for 0-6 h. Iodide treatment caused a reduction in NIS mRNA expression, half-life, poly(A) tail length, recruitment to ribosomes, as well as NIS protein expression.	Iodides	107-113	solute carrier family 5 member 5	Rattus norvegicus	146-149
22001309-7	2012	These data provide new insights about the molecular mechanisms involved in the rapid and posttranscriptional inhibitory effect of iodide on NIS expression.	Iodides	130-136	solute carrier family 5 member 5	Rattus norvegicus	140-143
22407327-4	2012	Incomplete iodide abstraction from [Ni(N(3)-CPQ)I(2)] with AgOTf leads to partial replacement of the iodide with hydroxide from adventitious water to give [Ni(N(3)-CPQ)I(1.6)(OH)(0.4)] (distorted TBP).	Iodides	11-17	TATA-box binding protein	Homo sapiens	196-199
22407327-4	2012	Incomplete iodide abstraction from [Ni(N(3)-CPQ)I(2)] with AgOTf leads to partial replacement of the iodide with hydroxide from adventitious water to give [Ni(N(3)-CPQ)I(1.6)(OH)(0.4)] (distorted TBP).	Iodides	101-107	TATA-box binding protein	Homo sapiens	196-199
21993965-1	2012	The sodium/iodide symporter (SLC5A5, also known as NIS) is a transmembrane glycoprotein.	Iodides	11-17	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	29-35
21993965-1	2012	The sodium/iodide symporter (SLC5A5, also known as NIS) is a transmembrane glycoprotein.	Iodides	11-17	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	51-54
22178794-0	2012	Iodide treatment acutely increases pendrin (SLC26A4) mRNA expression in the rat thyroid and the PCCl3 thyroid cell line by transcriptional mechanisms.	Iodides	0-6	solute carrier family 26 member 4	Rattus norvegicus	35-42
22178794-0	2012	Iodide treatment acutely increases pendrin (SLC26A4) mRNA expression in the rat thyroid and the PCCl3 thyroid cell line by transcriptional mechanisms.	Iodides	0-6	solute carrier family 26 member 4	Rattus norvegicus	44-51
22260520-9	2012	Furthermore, MEPI-Pd efficiently promoted the Suzuki-Miyaura reaction of a variety of inactivated aryl chlorides as well as aryl bromides and iodides in water with a TON of up to 3,570,000.	Iodides	142-149	serpin family I member 2	Homo sapiens	13-17
22132833-1	2012	CdS quantum dot sensitized solar cells based on TiO(2) photoanode and nanostructured carbon as well as Pt as counter electrodes using iodide/triiodide and polysulfide electrolytes were fabricated to improve the efficiency and reduce the cost of solar cells.	Iodides	134-140	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
22359623-1	2012	BACKGROUND: This study was designed to explore the therapeutic potential of suppressing MAP kinase and PI3K/Akt pathways and histone deacetylase (HDAC) to induce the expression of sodium/iodide symporter (NIS) and radioiodine uptake in non-thyroid cancer cells.	Iodides	187-193	AKT serine/threonine kinase 1	Homo sapiens	108-111
23029546-7	2012	Further, hAECs induced to express CFTR possessed functional iodide/chloride (I(-/)Cl(-)) ion channels that were inhibited by the CFTR-inhibitor CFTR-172, indicating the presence of functional CFTR ion channels.	Iodides	60-66	CF transmembrane conductance regulator	Homo sapiens	34-38
23029546-7	2012	Further, hAECs induced to express CFTR possessed functional iodide/chloride (I(-/)Cl(-)) ion channels that were inhibited by the CFTR-inhibitor CFTR-172, indicating the presence of functional CFTR ion channels.	Iodides	60-66	CF transmembrane conductance regulator	Homo sapiens	129-133
23029546-7	2012	Further, hAECs induced to express CFTR possessed functional iodide/chloride (I(-/)Cl(-)) ion channels that were inhibited by the CFTR-inhibitor CFTR-172, indicating the presence of functional CFTR ion channels.	Iodides	60-66	CF transmembrane conductance regulator	Homo sapiens	129-133
23029546-7	2012	Further, hAECs induced to express CFTR possessed functional iodide/chloride (I(-/)Cl(-)) ion channels that were inhibited by the CFTR-inhibitor CFTR-172, indicating the presence of functional CFTR ion channels.	Iodides	60-66	CF transmembrane conductance regulator	Homo sapiens	129-133
22109890-4	2012	The discovery of mutations in the SLC26A4 gene in patients with Pendred syndrome (congenital deafness, goiter, and defective iodide organification) suggested a possible role for the encoded protein, pendrin, as an apical iodide transporter.	Iodides	125-131	solute carrier family 26 member 4	Homo sapiens	34-41
22109890-4	2012	The discovery of mutations in the SLC26A4 gene in patients with Pendred syndrome (congenital deafness, goiter, and defective iodide organification) suggested a possible role for the encoded protein, pendrin, as an apical iodide transporter.	Iodides	125-131	solute carrier family 26 member 4	Homo sapiens	199-206
22109890-7	2012	The increase in pendrin membrane abundance correlates with a decrease in intracellular iodide as determined by measuring intracellular (125)iodide and can be inhibited by specific blocking of pendrin.	Iodides	87-93	solute carrier family 26 member 4	Rattus norvegicus	16-23
22109890-7	2012	The increase in pendrin membrane abundance correlates with a decrease in intracellular iodide as determined by measuring intracellular (125)iodide and can be inhibited by specific blocking of pendrin.	Iodides	87-93	solute carrier family 26 member 4	Rattus norvegicus	192-199
22109890-7	2012	The increase in pendrin membrane abundance correlates with a decrease in intracellular iodide as determined by measuring intracellular (125)iodide and can be inhibited by specific blocking of pendrin.	Iodides	140-146	solute carrier family 26 member 4	Rattus norvegicus	16-23
22109890-7	2012	The increase in pendrin membrane abundance correlates with a decrease in intracellular iodide as determined by measuring intracellular (125)iodide and can be inhibited by specific blocking of pendrin.	Iodides	140-146	solute carrier family 26 member 4	Rattus norvegicus	192-199
22109890-9	2012	These results demonstrate that pendrin translocates to the membrane in response to TSH and suggest that it may have a physiological role in apical iodide transport and thyroid hormone synthesis.	Iodides	147-153	solute carrier family 26 member 4	Rattus norvegicus	31-38
21441383-6	2011	However, substituting SCN(-) with the alternative LPO substrate iodide (I(-)) resulted in a marked reduction of both adenovirus transduction and RSV titer.	Iodides	64-70	lactoperoxidase	Homo sapiens	50-53
22033356-0	2011	Iodide and iodate (129I and 127I) in surface water of the Baltic Sea, Kattegat and Skagerrak.	Iodides	0-6	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	65-68
21903721-0	2011	Regulation of thyroid oxidative state by thioredoxin reductase has a crucial role in thyroid responses to iodide excess.	Iodides	106-112	peroxiredoxin 5	Rattus norvegicus	41-62
21899256-6	2011	Genistein protected GLUT1 against iodide-elicited fluorescence quenching and also decreased the affinity of d-glucose for its external binding site, while quercetin and tyrphostins B46 and A47 promoted fluorescence quenching and did not affect the external d-glucose binding site.	Iodides	34-40	solute carrier family 2 member 1	Homo sapiens	20-25
22074181-6	2011	Using iodide efflux assays, the probe molecules have been demonstrated to modulate the activity of mutant CFTR in the same manner as 1.	Iodides	6-12	CF transmembrane conductance regulator	Homo sapiens	106-110
21989294-1	2011	BACKGROUND: Na+/I- symporter (NIS)-mediated iodide uptake allows radioiodine therapy for thyroid cancer.	Iodides	44-50	solute carrier family 5 member 5	Homo sapiens	12-28
21989294-1	2011	BACKGROUND: Na+/I- symporter (NIS)-mediated iodide uptake allows radioiodine therapy for thyroid cancer.	Iodides	44-50	solute carrier family 5 member 5	Homo sapiens	30-33
21550633-3	2011	Because transport of iodide from the thyroid follicular cells to the follicular lumen is mediated by the protein pendrin at the apical surface, we hypothesized that perchlorate may also interact with this protein.	Iodides	21-27	solute carrier family 26 member 4	Homo sapiens	113-120
21844185-4	2011	Critically, iodide uptake was repressed in primary thyroid cultures from PBF-Tg mice, which could be rescued by PBF depletion.	Iodides	12-18	pituitary tumor-transforming 1 interacting protein	Mus musculus	73-76
21844185-4	2011	Critically, iodide uptake was repressed in primary thyroid cultures from PBF-Tg mice, which could be rescued by PBF depletion.	Iodides	12-18	pituitary tumor-transforming 1 interacting protein	Mus musculus	112-115
22073947-1	2011	OBJECTIVE: The aim of this work was to study the content of iodine as well as the expression of caspase 8 and caspase 32 in the thyroid and anterior pituitary in rats after a single dose of iodide.	Iodides	190-196	caspase 8	Rattus norvegicus	96-105
22073947-6	2011	RESULTS; In the thyroids, iodine concentration increased after 1 mug/100 g, but decreased after 8 and 25 mug/100 g, while that in the pituitaries significantly increased after all doses of iodide with the peak after 8 mg/100 g. After the same iodide dose also the peak of caspase 32 and caspase 8 appeared in the pituitary.	Iodides	189-195	caspase 8	Rattus norvegicus	287-296
21809831-1	2011	Thyroid peroxidase (TPO) plays an important role in thyroid hormone biosynthesis, as it catalyzes all of the essential steps in iodide organification.	Iodides	128-134	thyroid peroxidase	Homo sapiens	0-18
21809831-1	2011	Thyroid peroxidase (TPO) plays an important role in thyroid hormone biosynthesis, as it catalyzes all of the essential steps in iodide organification.	Iodides	128-134	thyroid peroxidase	Homo sapiens	20-23
20838926-5	2011	Application of iodide (I(-)) to lettuce plants produces a reduction in superoxide dismutase (SOD) activity and an increase in catalase (CAT) and L-galactono dehydrogenase enzyme activities and in the activity of antioxidant compounds such as ascorbate (AA) and glutathione.	Iodides	15-21	catalase	Homo sapiens	126-134
20838926-5	2011	Application of iodide (I(-)) to lettuce plants produces a reduction in superoxide dismutase (SOD) activity and an increase in catalase (CAT) and L-galactono dehydrogenase enzyme activities and in the activity of antioxidant compounds such as ascorbate (AA) and glutathione.	Iodides	15-21	catalase	Homo sapiens	136-139
21550633-8	2011	Thus, recombinant HeLa cells expressing pendrin protein accumulate iodide and perchlorate intracellularly, indicating that pendrin is involved in the uptake of perchlorate.	Iodides	67-73	solute carrier family 26 member 4	Homo sapiens	40-47
21550633-8	2011	Thus, recombinant HeLa cells expressing pendrin protein accumulate iodide and perchlorate intracellularly, indicating that pendrin is involved in the uptake of perchlorate.	Iodides	67-73	solute carrier family 26 member 4	Homo sapiens	123-130
21550633-9	2011	Additional results from this study suggest that iodide and perchlorate competitively inhibit each other for uptake by pendrin.	Iodides	48-54	solute carrier family 26 member 4	Homo sapiens	118-125
21761849-3	2011	Naturally occurring iodide in source waters is believed to be a primary source of iodine in the formation of iodo-DBPs, but a previous 23-city iodo-DBP occurrence study also revealed appreciable levels of iodo-DBPs in some drinking waters that had very low or no detectable iodide in their source waters.	Iodides	20-26	D-box binding PAR bZIP transcription factor	Homo sapiens	114-117
21702716-1	2011	INTRODUCTION: The mammalian target of rapamycin (mTOR) protein is a downstream effector of the phosphatidilinositol-3 kinase (PI3K)/Akt pathway, which regulates not only cell proliferation and viability, but also iodide uptake in thyroid cells.	Iodides	213-219	mechanistic target of rapamycin kinase	Homo sapiens	18-47
21702716-1	2011	INTRODUCTION: The mammalian target of rapamycin (mTOR) protein is a downstream effector of the phosphatidilinositol-3 kinase (PI3K)/Akt pathway, which regulates not only cell proliferation and viability, but also iodide uptake in thyroid cells.	Iodides	213-219	mechanistic target of rapamycin kinase	Homo sapiens	49-53
21702716-1	2011	INTRODUCTION: The mammalian target of rapamycin (mTOR) protein is a downstream effector of the phosphatidilinositol-3 kinase (PI3K)/Akt pathway, which regulates not only cell proliferation and viability, but also iodide uptake in thyroid cells.	Iodides	213-219	AKT serine/threonine kinase 1	Homo sapiens	132-135
20834201-3	2011	Since pendrin can transport iodide in vitro, variations in iodide supply have been claimed to account for the thyroid phenotype associated with pendrin defects.	Iodides	28-34	solute carrier family 26, member 4	Mus musculus	6-13
20834201-3	2011	Since pendrin can transport iodide in vitro, variations in iodide supply have been claimed to account for the thyroid phenotype associated with pendrin defects.	Iodides	59-65	solute carrier family 26, member 4	Mus musculus	144-151
20834201-4	2011	AIM: The Slc26a4 (-/-) mouse model was used to test the hypothesis that iodide supply may influence the penetrance and expressivity of SLC26A4 mutations.	Iodides	72-78	solute carrier family 26, member 4	Mus musculus	135-142
21708286-8	2011	We studied the CFTR maturation process using Western blot analysis and evaluated CFTR channel activity by automated iodide efflux assays.	Iodides	116-122	CF transmembrane conductance regulator	Homo sapiens	81-85
21797672-8	2011	The in vitro clonogenic assay indicated that, after exposure to 100-1000 muCi of (131)I-iodide for 12 hours, 91%-94% of cells cotransfected with the hNIS and hTPO genes, 88%-93% of cells transfected with the hNIS gene, and only 62%-68% of control (nontransfected) cells were killed.	Iodides	86-94	solute carrier family 5 member 5	Homo sapiens	149-153
21797672-8	2011	The in vitro clonogenic assay indicated that, after exposure to 100-1000 muCi of (131)I-iodide for 12 hours, 91%-94% of cells cotransfected with the hNIS and hTPO genes, 88%-93% of cells transfected with the hNIS gene, and only 62%-68% of control (nontransfected) cells were killed.	Iodides	86-94	thyroid peroxidase	Homo sapiens	158-162
21797672-8	2011	The in vitro clonogenic assay indicated that, after exposure to 100-1000 muCi of (131)I-iodide for 12 hours, 91%-94% of cells cotransfected with the hNIS and hTPO genes, 88%-93% of cells transfected with the hNIS gene, and only 62%-68% of control (nontransfected) cells were killed.	Iodides	86-94	solute carrier family 5 member 5	Homo sapiens	208-212
21797672-9	2011	CONCLUSIONS: The experiments demonstrated that an effective therapy of (131)I was achieved in malignant glioma cell lines after induction of tumor-specific iodide uptake activity by the hTERT promoter-directed NIS expression in vitro.	Iodides	156-162	telomerase reverse transcriptase	Homo sapiens	186-191
21797672-9	2011	CONCLUSIONS: The experiments demonstrated that an effective therapy of (131)I was achieved in malignant glioma cell lines after induction of tumor-specific iodide uptake activity by the hTERT promoter-directed NIS expression in vitro.	Iodides	156-162	solute carrier family 5 member 5	Homo sapiens	210-213
21411725-4	2011	Iodide effluxes were used to monitor the presence of VIP-rescued functional F508del-CFTR channels at the surface of JME/CF15 cells maintained at 37 C. Iodide efflux peaks measured in response to stimulation with forskolin were insensitive to PKC alpha, beta, gamma, delta, zeta inhibitors.	Iodides	151-157	vasoactive intestinal peptide	Homo sapiens	53-56
21801606-11	2011	These results demonstrated that radioiodine therapy was effective in treating malignant glioma cell lines following induction of tumor-specific iodide intake by the hTERT promoter-directed hNIS expression in vitro.	Iodides	144-150	telomerase reverse transcriptase	Homo sapiens	165-170
21801606-11	2011	These results demonstrated that radioiodine therapy was effective in treating malignant glioma cell lines following induction of tumor-specific iodide intake by the hTERT promoter-directed hNIS expression in vitro.	Iodides	144-150	solute carrier family 5 member 5	Homo sapiens	189-193
21499816-0	2011	Expression and localization of the sodium/iodide symporter (NIS) in testicular cells.	Iodides	42-48	solute carrier family 5 member 5	Homo sapiens	60-63
21499816-2	2011	Few data are available on the sodium/iodide symporter (NIS) expression in human testis, a particular important prerequisite to predict radioiodine accumulation in the gonads of males with thyroid cancer exposed to such a treatment.	Iodides	37-43	solute carrier family 5 member 5	Homo sapiens	55-58
21690268-3	2011	The results show that 0.1% iodine or iodide increases the expression of peroxisome proliferator-activated receptor type gamma (PPARgamma), triggering caspase-mediated apoptosis pathways in damaged mammary tissue (DMBA-treated mammary gland) as well as in frank mammary tumors, but not in normal mammary gland.	Iodides	37-43	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	72-137
21411725-4	2011	Iodide effluxes were used to monitor the presence of VIP-rescued functional F508del-CFTR channels at the surface of JME/CF15 cells maintained at 37 C. Iodide efflux peaks measured in response to stimulation with forskolin were insensitive to PKC alpha, beta, gamma, delta, zeta inhibitors.	Iodides	0-6	vasoactive intestinal peptide	Homo sapiens	53-56
21411725-4	2011	Iodide effluxes were used to monitor the presence of VIP-rescued functional F508del-CFTR channels at the surface of JME/CF15 cells maintained at 37 C. Iodide efflux peaks measured in response to stimulation with forskolin were insensitive to PKC alpha, beta, gamma, delta, zeta inhibitors.	Iodides	0-6	CF transmembrane conductance regulator	Homo sapiens	84-88
21411725-4	2011	Iodide effluxes were used to monitor the presence of VIP-rescued functional F508del-CFTR channels at the surface of JME/CF15 cells maintained at 37 C. Iodide efflux peaks measured in response to stimulation with forskolin were insensitive to PKC alpha, beta, gamma, delta, zeta inhibitors.	Iodides	151-157	CF transmembrane conductance regulator	Homo sapiens	84-88
21663237-5	2011	At ambient concentrations, iodide and iodate were significantly retarded (K(d) values as high as 49 mL g(-1)), whereas at concentrations of 78.7 muM, iodide traveled along with the water without retardation.	Iodides	150-156	latexin	Homo sapiens	145-148
21663237-7	2011	At high input concentration of iodate (78.7 muM), iodate was found to be reduced to iodide and subsequently followed the transport behavior of iodide.	Iodides	84-90	latexin	Homo sapiens	44-47
21663237-7	2011	At high input concentration of iodate (78.7 muM), iodate was found to be reduced to iodide and subsequently followed the transport behavior of iodide.	Iodides	143-149	latexin	Homo sapiens	44-47
21551164-1	2011	INTRODUCTION: Pendred syndrome, a combination of sensorineural deafness, impaired organification of iodide in the thyroid and goitre, results from biallelic defects in pendrin (encoded by SLC26A4), which transports chloride and iodide in the inner ear and thyroid respectively.	Iodides	100-106	solute carrier family 26 member 4	Homo sapiens	168-175
21449559-4	2011	With this strategy, 6 muM (0.76 ppm) of iodide can be recognized within 20 min by naked-eye observation.	Iodides	40-46	latexin	Homo sapiens	22-25
21551164-1	2011	INTRODUCTION: Pendred syndrome, a combination of sensorineural deafness, impaired organification of iodide in the thyroid and goitre, results from biallelic defects in pendrin (encoded by SLC26A4), which transports chloride and iodide in the inner ear and thyroid respectively.	Iodides	228-234	solute carrier family 26 member 4	Homo sapiens	168-175
21551164-1	2011	INTRODUCTION: Pendred syndrome, a combination of sensorineural deafness, impaired organification of iodide in the thyroid and goitre, results from biallelic defects in pendrin (encoded by SLC26A4), which transports chloride and iodide in the inner ear and thyroid respectively.	Iodides	228-234	solute carrier family 26 member 4	Homo sapiens	188-195
21565787-1	2011	CONTEXT: Iodide transport defect (ITD) is an autosomal recessive disorder caused by impaired Na(+)/I(-) symporter (NIS)-mediated active iodide accumulation into thyroid follicular cells.	Iodides	136-142	solute carrier family 5 member 5	Homo sapiens	93-113
21565787-1	2011	CONTEXT: Iodide transport defect (ITD) is an autosomal recessive disorder caused by impaired Na(+)/I(-) symporter (NIS)-mediated active iodide accumulation into thyroid follicular cells.	Iodides	136-142	solute carrier family 5 member 5	Homo sapiens	115-118
21565787-11	2011	Functional evaluation of the molecular mechanism responsible for impaired NIS-mediated iodide concentration in thyroid cells indicated that the identified mutation reduces NIS translation efficiency with a subsequent decrease in protein expression and function.	Iodides	87-93	solute carrier family 5 member 5	Homo sapiens	74-77
21565787-11	2011	Functional evaluation of the molecular mechanism responsible for impaired NIS-mediated iodide concentration in thyroid cells indicated that the identified mutation reduces NIS translation efficiency with a subsequent decrease in protein expression and function.	Iodides	87-93	solute carrier family 5 member 5	Homo sapiens	172-175
21989446-0	2011	Expression and correlation of sodium/iodide symporter and thyroid stimulating hormone receptor in human thyroid carcinoma.	Iodides	37-43	thyroid stimulating hormone receptor	Homo sapiens	58-94
21389275-10	2011	In summary, we provide novel evidence that AMPK is involved in the physiological regulation of iodide uptake, which is an essential step for the formation of thyroid hormones as well as for the regulation of thyroid function.	Iodides	95-101	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	43-47
21702220-3	2011	The iodide is transported inside the thyroid epithelial cell via sodium iodide symporter (NIS) which is a trans-membrane protein.	Iodides	4-10	solute carrier family 5 member 5	Homo sapiens	90-93
21389275-0	2011	A novel role for AMP-kinase in the regulation of the Na+/I--symporter and iodide uptake in the rat thyroid gland.	Iodides	74-80	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	17-27
21389275-1	2011	The aim of this study was to investigate the role of AMP-kinase (AMPK) in the regulation of iodide uptake by the thyroid gland.	Iodides	92-98	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	53-63
21389275-1	2011	The aim of this study was to investigate the role of AMP-kinase (AMPK) in the regulation of iodide uptake by the thyroid gland.	Iodides	92-98	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	65-69
21389275-2	2011	Iodide uptake was assessed in PCCL3 follicular thyroid cells exposed to the AMPK agonist 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR), and also in rat thyroid glands 24 h after a single intraperitoneal injection of AICAR.	Iodides	0-6	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	76-80
21389275-3	2011	In PCCL3 cells, AICAR-induced AMPK and acetyl-CoA carboxylase (ACC) phosphorylation decreased iodide uptake in a concentration-dependent manner, while the AMPK inhibitor compound C prevented this effect.	Iodides	94-100	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	30-34
21503323-1	2011	Iodide adsorption and electrochemical negative potential desorption were proposed and compared to obtain clean SERS substrates.	Iodides	0-6	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	111-115
21511235-4	2011	In the thyroid, pendrin is expressed at the apical membrane of thyroid follicular cells and it appears to be involved in mediating iodide efflux into the lumen and/or maintenance of the follicular pH.	Iodides	131-137	solute carrier family 26 member 4	Homo sapiens	16-23
21412686-8	2011	Our results demonstrate a link between decrease in DPP IV activity and increase in iodide uptake upon stimulation with differentiating agents.	Iodides	83-89	dipeptidyl peptidase 4	Homo sapiens	51-57
21315800-12	2011	TS7 cells induced a decrease in iodide uptake by PC CL3 cells, probably by a mechanism involving TGF-beta1.	Iodides	32-38	transforming growth factor, beta 1	Rattus norvegicus	97-106
21367925-1	2011	CONTEXT: Dual oxidases (DUOX1 and DUOX2) play a crucial role in the generation of hydrogen peroxide required in the oxidation of iodide and the synthesis of thyroid hormone.	Iodides	129-135	dual oxidase 1	Homo sapiens	24-29
21367925-1	2011	CONTEXT: Dual oxidases (DUOX1 and DUOX2) play a crucial role in the generation of hydrogen peroxide required in the oxidation of iodide and the synthesis of thyroid hormone.	Iodides	129-135	dual oxidase 2	Homo sapiens	34-39
21245850-3	2011	Incubation of HuH7 cells with LPEI-PEG-GE11/NIS polyplexes resulted in a 22-fold increase in iodide uptake, which was confirmed in other cancer cell lines correlating well with EGFR expression levels.	Iodides	93-99	MIR7-3 host gene	Homo sapiens	14-18
21245850-7	2011	After pretreatment with the EGFR-specific antibody cetuximab, tumoral iodide uptake was markedly reduced confirming the specificity of EGFR-targeted polyplexes.	Iodides	70-76	epidermal growth factor receptor	Homo sapiens	28-32
21245850-3	2011	Incubation of HuH7 cells with LPEI-PEG-GE11/NIS polyplexes resulted in a 22-fold increase in iodide uptake, which was confirmed in other cancer cell lines correlating well with EGFR expression levels.	Iodides	93-99	epidermal growth factor receptor	Homo sapiens	177-181
21245850-7	2011	After pretreatment with the EGFR-specific antibody cetuximab, tumoral iodide uptake was markedly reduced confirming the specificity of EGFR-targeted polyplexes.	Iodides	70-76	epidermal growth factor receptor	Homo sapiens	135-139
21245850-9	2011	These results demonstrate that systemic NIS gene transfer using polyplexes coupled with an EGFR-targeting ligand is capable of inducing tumor-specific iodide uptake, which represents a promising innovative strategy for systemic NIS gene therapy in metastatic cancers.	Iodides	151-157	epidermal growth factor receptor	Homo sapiens	91-95
21245850-4	2011	Using (123)I-scintigraphy and ex vivo gamma-counting, HuH7 xenografts accumulated 6.5-9% injected dose per gram (ID/g) (123)I, resulting in a tumor-absorbed dose of 47 mGray/Megabecquerel (mGy/MBq) (131)Iodide ((131)I) after intravenous (i.v.)	Iodides	203-209	MIR7-3 host gene	Homo sapiens	54-58
21209020-1	2011	Na(+)/I(-) symporter (NIS)-mediated iodide uptake into thyroid follicular cells serves as the basis of radioiodine therapy for thyroid cancer.	Iodides	36-42	solute carrier family 5 member 5	Homo sapiens	0-20
21085047-1	2011	PURPOSE: Accumulation of iodide and other substrates via the human sodium/iodide symporter (hNIS) is fundamental to imaging and therapy of thyroid disease, hNIS reporter gene imaging and hNIS-mediated gene therapy.	Iodides	25-31	solute carrier family 5 member 5	Rattus norvegicus	67-90
21035537-6	2011	Iodide tunes down the biological activity of autonomous thyrocytes and may thus be of therapeutic benefit not only to prevent the occurrence of somatic TSHR mutations, causing thyroid autonomy, but also to slow down the development of clinically relevant disease.	Iodides	0-6	thyroid stimulating hormone receptor	Rattus norvegicus	152-156
20479570-2	2011	The human sodium/iodide symporter (hNIS) is an integral plasma membrane glycoprotein mediating the active transport of iodide into thyroid follicular cells, a crucial step for thyroid hormone biosynthesis.	Iodides	17-23	solute carrier family 5 member 5	Homo sapiens	35-39
20479570-4	2011	AIM: The aim of this study was to investigate if 10 substances usually used as drugs in clinical practice were able to inhibit NIS-mediated iodide uptake in vitro.	Iodides	140-146	solute carrier family 5 member 5	Homo sapiens	127-130
20479570-9	2011	CONCLUSIONS: In conclusion, we carried out an in vitro assay to evaluate the potential inhibitory effect of common drugs on NISmediated iodide uptake by using CHO-hNIS cells.	Iodides	136-142	solute carrier family 5 member 5	Homo sapiens	163-167
21085047-1	2011	PURPOSE: Accumulation of iodide and other substrates via the human sodium/iodide symporter (hNIS) is fundamental to imaging and therapy of thyroid disease, hNIS reporter gene imaging and hNIS-mediated gene therapy.	Iodides	25-31	solute carrier family 5 member 5	Homo sapiens	92-96
21085047-1	2011	PURPOSE: Accumulation of iodide and other substrates via the human sodium/iodide symporter (hNIS) is fundamental to imaging and therapy of thyroid disease, hNIS reporter gene imaging and hNIS-mediated gene therapy.	Iodides	25-31	solute carrier family 5 member 5	Homo sapiens	156-160
21085047-1	2011	PURPOSE: Accumulation of iodide and other substrates via the human sodium/iodide symporter (hNIS) is fundamental to imaging and therapy of thyroid disease, hNIS reporter gene imaging and hNIS-mediated gene therapy.	Iodides	25-31	solute carrier family 5 member 5	Homo sapiens	156-160
22116353-1	2011	Pendrin (SLC26A4), a Cl(-)/anion exchanger encoded by the gene PDS, is highly expressed in the kidney, thyroid and inner ear epithelia and is essential for bicarbonate secretion/chloride reabsorption, iodide accumulation and endolymph ion balance, respectively.	Iodides	201-207	solute carrier family 26 member 4	Homo sapiens	9-16
21358184-6	2011	SLC26A4 encodes the pendrin polypeptide, an anion exchanger that, in recombinant expression systems, transports chloride, bicarbonate, and iodide.	Iodides	139-145	solute carrier family 26 member 4	Homo sapiens	0-7
21358184-6	2011	SLC26A4 encodes the pendrin polypeptide, an anion exchanger that, in recombinant expression systems, transports chloride, bicarbonate, and iodide.	Iodides	139-145	solute carrier family 26 member 4	Homo sapiens	20-27
22116353-1	2011	Pendrin (SLC26A4), a Cl(-)/anion exchanger encoded by the gene PDS, is highly expressed in the kidney, thyroid and inner ear epithelia and is essential for bicarbonate secretion/chloride reabsorption, iodide accumulation and endolymph ion balance, respectively.	Iodides	201-207	solute carrier family 26 member 4	Homo sapiens	0-7
22116353-1	2011	Pendrin (SLC26A4), a Cl(-)/anion exchanger encoded by the gene PDS, is highly expressed in the kidney, thyroid and inner ear epithelia and is essential for bicarbonate secretion/chloride reabsorption, iodide accumulation and endolymph ion balance, respectively.	Iodides	201-207	solute carrier family 26 member 4	Homo sapiens	63-66
22116370-1	2011	SLC26A4 encodes pendrin, a transporter exchanging anions such as chloride, bicarbonate, and iodide.	Iodides	92-98	solute carrier family 26, member 4	Mus musculus	0-7
22116356-2	2011	Pendrin (SLC26A4) is inserted into the apical membrane of thyrocytes and thought to be involved in mediating iodide efflux.	Iodides	109-115	solute carrier family 26 member 4	Homo sapiens	0-7
22116370-1	2011	SLC26A4 encodes pendrin, a transporter exchanging anions such as chloride, bicarbonate, and iodide.	Iodides	92-98	solute carrier family 26, member 4	Mus musculus	16-23
22116356-2	2011	Pendrin (SLC26A4) is inserted into the apical membrane of thyrocytes and thought to be involved in mediating iodide efflux.	Iodides	109-115	solute carrier family 26 member 4	Homo sapiens	9-16
22116356-3	2011	METHODS: We determined the effects of carboxy-terminal mutations of pendrin on the cellular localization and the ability to transport iodide.	Iodides	134-140	solute carrier family 26 member 4	Homo sapiens	68-75
22116356-8	2011	CONCLUSION: Pendrin membrane abundance and its ability to mediate iodide efflux increase after activation of the PKA pathway.	Iodides	66-72	solute carrier family 26 member 4	Homo sapiens	12-19
22116358-2	2011	In the thyroid, pendrin is expressed at the apical membrane of the follicular epithelium and may be involved in mediating apical iodide efflux into the follicle; in the inner ear, it plays a crucial role in the conditioning of the pH and ion composition of the endolymph; in the kidney, it may exert a role in pH homeostasis and regulation of blood pressure.	Iodides	129-135	solute carrier family 26 member 4	Homo sapiens	16-23
22116359-1	2011	BACKGROUND: Pendrin is a multifunctional anion transporter that exchanges chloride and iodide in the thyroid, as well as chloride and bicarbonate in the inner ear, kidney and airways.	Iodides	87-93	solute carrier family 26 member 4	Homo sapiens	12-19
22116360-1	2011	BACKGROUND: Pendrin is a transport protein exchanging chloride for other anions, such as iodide in the thyroid gland or bicarbonate in the inner ear.	Iodides	89-95	solute carrier family 26 member 4	Homo sapiens	12-19
22116360-8	2011	RESULTS: Both the Cl(-)/I(-) and the Cl(-)/OH(-) exchange activities of pendrin V239D, G334V X335 and I487Y FSX39 were significantly reduced with respect to the wild type, with V239D displaying a residual iodide transport.	Iodides	205-211	solute carrier family 26 member 4	Homo sapiens	72-79
22116361-4	2011	The clinical phenotype of patients with Pendred syndrome and the fact that pendrin can mediate iodide efflux in transfected cells suggest that this anion exchanger may be involved in mediating iodide efflux into the follicular lumen, a key step in thyroid hormone biosynthesis.	Iodides	95-101	solute carrier family 26 member 4	Homo sapiens	75-82
22116361-4	2011	The clinical phenotype of patients with Pendred syndrome and the fact that pendrin can mediate iodide efflux in transfected cells suggest that this anion exchanger may be involved in mediating iodide efflux into the follicular lumen, a key step in thyroid hormone biosynthesis.	Iodides	193-199	solute carrier family 26 member 4	Homo sapiens	75-82
22116361-6	2011	This review discusses supporting evidence as well as arguments questioning a role of pendrin in mediating iodide efflux in thyrocytes.	Iodides	106-112	solute carrier family 26 member 4	Homo sapiens	85-92
22116362-8	2011	Moreover, ectopic expression of pendrin in transfected non-thyroid cells is capable of mediating iodide efflux.	Iodides	97-103	solute carrier family 26 member 4	Homo sapiens	32-39
22116362-9	2011	It is concluded that pendrin may participate in the iodide efflux into thyroid lumen but not as the unique transporter.	Iodides	52-58	solute carrier family 26 member 4	Homo sapiens	21-28
22116363-1	2011	The anion exchanger pendrin (Pds, SLC26A4) transports various anions including bicarbonate, chloride and iodide.	Iodides	105-111	solute carrier family 26, member 4	Mus musculus	20-27
22116363-1	2011	The anion exchanger pendrin (Pds, SLC26A4) transports various anions including bicarbonate, chloride and iodide.	Iodides	105-111	solute carrier family 26, member 4	Mus musculus	34-41
21314207-9	2011	CONCLUSION: It was found that in the pituitaries of rat females the expression of NIS started after the dose of 4 mug iodide/100g, while that in the thyroids started after 8 mug iodide/100g.	Iodides	118-124	solute carrier family 5 member 5	Rattus norvegicus	82-85
21314207-1	2011	OBJECTIVE: The aim of this work was to study the expression of NIS in the thyroid and anterior pituitary in rats after a single dose of iodide appropriate to the content of iodide in iodine-positive points in the thyroid and pituitary.	Iodides	136-142	solute carrier family 5 member 5	Rattus norvegicus	63-66
21314207-1	2011	OBJECTIVE: The aim of this work was to study the expression of NIS in the thyroid and anterior pituitary in rats after a single dose of iodide appropriate to the content of iodide in iodine-positive points in the thyroid and pituitary.	Iodides	173-179	solute carrier family 5 member 5	Rattus norvegicus	63-66
21314207-9	2011	CONCLUSION: It was found that in the pituitaries of rat females the expression of NIS started after the dose of 4 mug iodide/100g, while that in the thyroids started after 8 mug iodide/100g.	Iodides	178-184	solute carrier family 5 member 5	Rattus norvegicus	82-85
21314207-7	2011	Histochemical reaction for NIS in the pituitaries at 48 hours after iodide administration showed a dose related increase beginning from 4 mug/100 g (from 1.8+-0.7 to 12.9+-1.0 % PA, respectively to the dose of iodide), while such increase in the thyroids started from 8 mug/100g (from 3.7+-1.2 to 9.1+-2.0 % PA).	Iodides	68-74	solute carrier family 5 member 5	Rattus norvegicus	27-30
21050066-0	2010	Optimization of a Yellow fluorescent protein-based iodide influx high-throughput screening assay for cystic fibrosis transmembrane conductance regulator (CFTR) modulators.	Iodides	51-57	CF transmembrane conductance regulator	Homo sapiens	101-152
21314207-7	2011	Histochemical reaction for NIS in the pituitaries at 48 hours after iodide administration showed a dose related increase beginning from 4 mug/100 g (from 1.8+-0.7 to 12.9+-1.0 % PA, respectively to the dose of iodide), while such increase in the thyroids started from 8 mug/100g (from 3.7+-1.2 to 9.1+-2.0 % PA).	Iodides	210-216	solute carrier family 5 member 5	Rattus norvegicus	27-30
21594775-4	2011	CFTR activity can be simply assessed by measuring the rate of YFP signal decrease caused by iodide influx.	Iodides	92-98	CF transmembrane conductance regulator	Homo sapiens	0-4
21090606-5	2010	The median perchlorate, nitrate, and iodide levels measured in tap water were 1.16, 758, and 4.55 mug/L, respectively.	Iodides	37-43	nuclear RNA export factor 1	Homo sapiens	63-66
21090606-10	2010	Using individual tap water consumption data and body weight, we estimated the median perchlorate, nitrate, and iodide dose attributable to tap water as 9.11, 11300, and 43.3 ng/kg-day, respectively, for U.S. adults.	Iodides	111-117	nuclear RNA export factor 1	Homo sapiens	139-142
22220168-4	2011	We have previously generated a stable human NIS-expressing ATC cell line, ARO, and the ability of iodide accumulation was restored.	Iodides	98-104	solute carrier family 5 member 5	Homo sapiens	44-47
21090606-0	2010	Perchlorate, nitrate, and iodide intake through tap water.	Iodides	26-32	nuclear RNA export factor 1	Homo sapiens	48-51
21090606-3	2010	This study investigates the intake of perchlorate, nitrate, and iodide attributable to direct and indirect tap water consumption.	Iodides	64-70	nuclear RNA export factor 1	Homo sapiens	107-110
21050066-0	2010	Optimization of a Yellow fluorescent protein-based iodide influx high-throughput screening assay for cystic fibrosis transmembrane conductance regulator (CFTR) modulators.	Iodides	51-57	CF transmembrane conductance regulator	Homo sapiens	154-158
20577737-1	2010	PURPOSE: The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters (123)I-iodide, (131)I-iodide and (99m)Tc-pertechnetate.	Iodides	150-158	solute carrier family 5 member 5	Rattus norvegicus	19-42
20213084-4	2010	In the present study, we report for the first time that the pan-deacetylase (DAC) inhibitor LBH589 (panobinostat) significantly induced NIS, both as mRNA and as protein, through the increase of NIS promoter activity, with the final consequence of obtaining a significant up-take of iodide in MCF7, T47D, and MDA-MB231 breast cancer cells.	Iodides	282-288	arylacetamide deacetylase	Homo sapiens	77-80
20577737-1	2010	PURPOSE: The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters (123)I-iodide, (131)I-iodide and (99m)Tc-pertechnetate.	Iodides	150-158	solute carrier family 5 member 5	Homo sapiens	44-48
20577737-1	2010	PURPOSE: The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters (123)I-iodide, (131)I-iodide and (99m)Tc-pertechnetate.	Iodides	165-173	solute carrier family 5 member 5	Rattus norvegicus	19-42
20577737-1	2010	PURPOSE: The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters (123)I-iodide, (131)I-iodide and (99m)Tc-pertechnetate.	Iodides	165-173	solute carrier family 5 member 5	Homo sapiens	44-48
20667985-2	2010	Na(+)/I(-) symporter (NIS)-mediated iodide uptake is the main rate-limiting step in thyroid hormonogenesis.	Iodides	36-42	solute carrier family 5 member 5	Rattus norvegicus	0-20
20428214-1	2010	The sodium iodide symporter (NIS) directs the uptake and concentration of iodide in thyroid cells.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
20667985-2	2010	Na(+)/I(-) symporter (NIS)-mediated iodide uptake is the main rate-limiting step in thyroid hormonogenesis.	Iodides	36-42	solute carrier family 5 member 5	Rattus norvegicus	22-25
20629553-2	2010	The objective of this study was to determine the effects of sunitinib on signal transduction pathways and on gene expression of iodide-metabolizing proteins in papillary cancer cells with the RET/PTC1 rearrangement.	Iodides	128-134	ret proto-oncogene	Homo sapiens	192-195
20662522-5	2010	Consequently, we directly probed the effect of crowding on the denatured state of CRABP I by measuring side-chain accessibility using iodide quenching of tryptophan fluorescence and chemical modification of cysteines.	Iodides	134-140	cellular retinoic acid binding protein 1	Homo sapiens	82-89
20704397-1	2010	Complementary palladium-catalyzed methods for direct arylation of oxazole with high regioselectivity (&gt;100:1) at both C-5 and C-2 have been developed for a wide range of aryl and heteroaryl bromides, chlorides, iodides, and triflates.	Iodides	214-221	complement C2	Homo sapiens	129-132
20825298-2	2010	Other studies have shown that transforming growth factor beta-1 (TGF-beta1) mimics some of the actions of excess iodide, but its participation in autoregulation is disputed.	Iodides	113-119	transforming growth factor, beta 1	Rattus norvegicus	30-63
20825298-2	2010	Other studies have shown that transforming growth factor beta-1 (TGF-beta1) mimics some of the actions of excess iodide, but its participation in autoregulation is disputed.	Iodides	113-119	transforming growth factor, beta 1	Rattus norvegicus	65-74
20825298-3	2010	The present studies were performed to test the hypotheses that IL-delta decreases thyroid growth by inhibition of cell proliferation and/or by stimulation of apoptosis due to oxidative stress, that TGF-beta is stimulated by an excess of iodide and by IL-delta, and that c-Myc and c-Fos expression are upregulated during goiter induction and downregulated during goiter inhibition.	Iodides	237-243	transforming growth factor, beta 1	Rattus norvegicus	198-206
20825298-17	2010	Iodide stimulates TGF-beta3 without the need of being organified.	Iodides	0-6	transforming growth factor, beta 3	Rattus norvegicus	18-27
20501687-7	2010	CONCLUSION: In conclusion, the absence of pendrin is accompanied by increased ClC-5 expression that may transiently compensate for apical iodide efflux.	Iodides	138-144	chloride voltage-gated channel 5	Homo sapiens	78-83
20110398-4	2010	Here, we present the effect of GPact-11a on CFTR activity using in vitro (iodide efflux, fluorescence imaging and patch-clamp recordings), ex vivo (short-circuit current measurements) and in vivo (salivary secretion) experiments.	Iodides	74-80	CF transmembrane conductance regulator	Homo sapiens	44-48
24900222-3	2010	A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.	Iodides	133-140	cytochrome c, somatic	Homo sapiens	45-57
20529371-0	2010	Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice.	Iodides	37-43	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	55-58
20799850-1	2010	OBJECTIVE: The aim of this work was to study the effect of a single dose of iodide on the expression of apoptosis mediating enzymes (caspase 32 and caspase 8) as well as of antiapoptopic protein Bcl-2 in the anterior pituitary, thyroid and ovaries in rats.	Iodides	76-82	caspase 8	Rattus norvegicus	148-157
30780803-5	2010	Pendrin is the primary protein that is responsible for iodide efflux out of the thyrocyte and into the follicular lumen.	Iodides	55-61	solute carrier family 26 member 4	Homo sapiens	0-7
20392814-0	2010	MTOR downregulates iodide uptake in thyrocytes.	Iodides	19-25	mechanistic target of rapamycin kinase	Rattus norvegicus	0-4
20392814-4	2010	Here, we show that MTOR inhibition by rapamycin increases iodide uptake in TSH-stimulated PCCL3 thyroid cell line, although the effect of rapamycin was less pronounced than PI3K inhibition.	Iodides	58-64	mechanistic target of rapamycin kinase	Rattus norvegicus	19-23
20122987-8	2010	Expressivity of the defects can be highly variable owning to the presence of genetic modifiers (e.g., the paralogs DUOX1 and DUOXA1), and environmental factors particularly nutritional iodide intake.	Iodides	185-191	dual oxidase 1	Homo sapiens	115-120
20122987-8	2010	Expressivity of the defects can be highly variable owning to the presence of genetic modifiers (e.g., the paralogs DUOX1 and DUOXA1), and environmental factors particularly nutritional iodide intake.	Iodides	185-191	dual oxidase maturation factor 1	Homo sapiens	125-131
20298745-5	2010	In the thyroid, pendrin localizes to the apical membrane of thyrocytes, where it may be involved in mediating iodide efflux.	Iodides	110-116	solute carrier family 26 member 4	Homo sapiens	16-23
20298745-6	2010	Loss-of-function mutations in the SLC26A4 gene are associated with a partial iodide organification defect, presumably because of a reduced iodide efflux into the follicular lumen.	Iodides	77-83	solute carrier family 26 member 4	Homo sapiens	34-41
20529371-1	2010	BACKGROUND: Iodide that is essential for thyroid hormone synthesis is actively transported into the thyroid follicular cells via sodium/iodide symporter (NIS) protein in vertebrates.	Iodides	12-18	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	154-157
20681442-3	2010	The aim of this study is to transfer the human sodium/iodide symporter (hNIS) and the human thyroperoxidase (hTPO) genes into H460 lung cancer cell line, and to study the uptake ability of iodide after co-transfected hTPO and hNIS gene in cell lines.	Iodides	54-60	solute carrier family 5 member 5	Homo sapiens	72-76
20517942-9	2010	We observed activation of CFTR Cl(-) channels with iodide efflux, on addition of forskolin, 3-isobutyl-1-methyl-xanthine, and 8-chlorphenylthio-cyclic adenosine monophosphate, in wild-type C57BL/6J isolated muscle fibers in contrast to no efflux from mutant F508del-CFTR muscle.	Iodides	51-57	CF transmembrane conductance regulator	Homo sapiens	26-30
20517942-9	2010	We observed activation of CFTR Cl(-) channels with iodide efflux, on addition of forskolin, 3-isobutyl-1-methyl-xanthine, and 8-chlorphenylthio-cyclic adenosine monophosphate, in wild-type C57BL/6J isolated muscle fibers in contrast to no efflux from mutant F508del-CFTR muscle.	Iodides	51-57	CF transmembrane conductance regulator	Homo sapiens	266-270
20123735-1	2010	Activity of the sodium/iodide symporter (NIS) in lactating breast is essential for iodide (I(-)) accumulation in milk.	Iodides	23-29	solute carrier family 5 member 5	Homo sapiens	41-44
20681442-3	2010	The aim of this study is to transfer the human sodium/iodide symporter (hNIS) and the human thyroperoxidase (hTPO) genes into H460 lung cancer cell line, and to study the uptake ability of iodide after co-transfected hTPO and hNIS gene in cell lines.	Iodides	189-195	solute carrier family 5 member 5	Homo sapiens	72-76
20681442-3	2010	The aim of this study is to transfer the human sodium/iodide symporter (hNIS) and the human thyroperoxidase (hTPO) genes into H460 lung cancer cell line, and to study the uptake ability of iodide after co-transfected hTPO and hNIS gene in cell lines.	Iodides	189-195	thyroid peroxidase	Homo sapiens	92-107
20681442-3	2010	The aim of this study is to transfer the human sodium/iodide symporter (hNIS) and the human thyroperoxidase (hTPO) genes into H460 lung cancer cell line, and to study the uptake ability of iodide after co-transfected hTPO and hNIS gene in cell lines.	Iodides	189-195	thyroid peroxidase	Homo sapiens	109-113
20681442-3	2010	The aim of this study is to transfer the human sodium/iodide symporter (hNIS) and the human thyroperoxidase (hTPO) genes into H460 lung cancer cell line, and to study the uptake ability of iodide after co-transfected hTPO and hNIS gene in cell lines.	Iodides	189-195	thyroid peroxidase	Homo sapiens	217-221
20681442-3	2010	The aim of this study is to transfer the human sodium/iodide symporter (hNIS) and the human thyroperoxidase (hTPO) genes into H460 lung cancer cell line, and to study the uptake ability of iodide after co-transfected hTPO and hNIS gene in cell lines.	Iodides	189-195	solute carrier family 5 member 5	Homo sapiens	226-230
20089668-8	2010	As CFTR transports chloride as well as other halides, we conjugated an iodide-sensitive probe as an independent approach to confirm the results.	Iodides	71-77	CF transmembrane conductance regulator	Homo sapiens	3-7
20089668-10	2010	CFTR(inh)172 blocked 40-50% of the overall iodide uptake by phagosomes in normal neutrophils.	Iodides	43-49	CF transmembrane conductance regulator	Homo sapiens	0-4
19184627-6	2010	The TII concentration for tap water was close to that of Lake Mead (approximately 90 nM); however, tap water contained no detectable iodide as a result of ozonation and chlorine treatment which converts all of the iodide to iodate.	Iodides	214-220	nuclear RNA export factor 1	Homo sapiens	99-102
20228127-0	2010	Human sodium-iodide symporter (hNIS) gene expression is inhibited by a trans-active transcriptional repressor, NIS-repressor, containing PARP-1 in thyroid cancer cells.	Iodides	13-19	solute carrier family 5 member 5	Homo sapiens	31-35
20228127-0	2010	Human sodium-iodide symporter (hNIS) gene expression is inhibited by a trans-active transcriptional repressor, NIS-repressor, containing PARP-1 in thyroid cancer cells.	Iodides	13-19	solute carrier family 5 member 5	Homo sapiens	32-35
20187165-2	2010	H(2)O(2) is used by thyroperoxidase to oxidize iodide for thyroid hormonogenesis.	Iodides	47-53	thyroid peroxidase	Homo sapiens	20-35
24899932-2	2010	Iodide uptake occurs across the membrane of the thyroid follicular cells and cancer cells through an active transporter process mediated by the sodium iodide symporter (NIS).	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	169-172
20132794-0	2010	Excess iodide decreases transcription of NIS and VEGF genes in rat FRTL-5 thyroid cells.	Iodides	7-13	solute carrier family 5 member 5	Rattus norvegicus	41-44
20132794-0	2010	Excess iodide decreases transcription of NIS and VEGF genes in rat FRTL-5 thyroid cells.	Iodides	7-13	vascular endothelial growth factor A	Rattus norvegicus	49-53
20132794-2	2010	The functional effect of iodide occurs at multiple steps, which include inhibition of sodium/iodide symporter (NIS) expression, transient block of organification, and inhibition of hormonal release.	Iodides	25-31	solute carrier family 5 member 5	Rattus norvegicus	111-114
20132794-4	2010	In this report, we show that excess iodide coordinately suppresses the expression of the NIS and VEGF genes in FRTL-5 thyroid cells.	Iodides	36-42	solute carrier family 5 member 5	Rattus norvegicus	89-92
20132794-4	2010	In this report, we show that excess iodide coordinately suppresses the expression of the NIS and VEGF genes in FRTL-5 thyroid cells.	Iodides	36-42	vascular endothelial growth factor A	Rattus norvegicus	97-101
20132794-5	2010	We also demonstrate that the mechanism of iodide suppression of NIS gene expression is transcriptional, which is synergized by the addition of thyroglobulin.	Iodides	42-48	solute carrier family 5 member 5	Rattus norvegicus	64-67
20132794-6	2010	Based on the findings of reporter gene assays and electrophoretic gel mobility shift analysis, we also report two novel DNA binding proteins that responded specifically to iodide and modulated NIS promoter activity.	Iodides	172-178	solute carrier family 5 member 5	Rattus norvegicus	193-196
20228127-0	2010	Human sodium-iodide symporter (hNIS) gene expression is inhibited by a trans-active transcriptional repressor, NIS-repressor, containing PARP-1 in thyroid cancer cells.	Iodides	13-19	poly(ADP-ribose) polymerase 1	Homo sapiens	137-143
20107044-4	2010	We investigated whether acute iodide administration could trigger events that precede those changes, such as reduction of sodium-iodide symporter (NIS) mRNA abundance and adenylation, and if perchlorate treatment could counteract them.	Iodides	30-36	solute carrier family 5 member 5	Rattus norvegicus	122-145
19733144-0	2010	A nonradioactive iodide uptake assay for sodium iodide symporter function.	Iodides	17-23	solute carrier family 5 member 5	Rattus norvegicus	41-64
20008023-4	2010	RESULTS: The expression of a large number of iodide-handling genes could be restored, particularly the sodium/iodide symporter, TSH receptor, and thyroperoxidase, by treating cells with these inhibitors.	Iodides	45-51	thyroid peroxidase	Homo sapiens	146-161
19618116-2	2010	The sodium iodide symporter, NIS, actively transports iodide across the plasma membrane and is exploited clinically to deliver radioactive iodide into cells.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
19951699-9	2010	These results suggest that a low levels of Tg in the follicular lumen might stimulates cell growth and iodide transport to accelerate the iodide organification process; however, elevated Tg levels in the follicle might then shut down all of these functions.	Iodides	103-109	thyroglobulin	Rattus norvegicus	43-45
19951699-9	2010	These results suggest that a low levels of Tg in the follicular lumen might stimulates cell growth and iodide transport to accelerate the iodide organification process; however, elevated Tg levels in the follicle might then shut down all of these functions.	Iodides	138-144	thyroglobulin	Rattus norvegicus	43-45
19768779-0	2010	Activation of lactoperoxidase by heme-linked protonation and heme-independent iodide binding.	Iodides	78-84	lactoperoxidase	Homo sapiens	14-29
19768779-2	2010	Although LPO is known to be activated at acidic pH and in the presence of iodide, the structural basis of the activation is not well understood.	Iodides	74-80	lactoperoxidase	Homo sapiens	9-12
19768779-3	2010	We have examined the effects of pH and iodide concentration on the catalytic activity and the structure of LPO.	Iodides	39-45	lactoperoxidase	Homo sapiens	107-110
19768779-8	2010	Binding of iodide enhances the catalytic activity of LPO without affecting either the optimum pH of activity or the heme structure, implying that the iodide binding occurs at a protein site away from the heme-linked protonation site.	Iodides	11-17	lactoperoxidase	Homo sapiens	53-56
19768779-8	2010	Binding of iodide enhances the catalytic activity of LPO without affecting either the optimum pH of activity or the heme structure, implying that the iodide binding occurs at a protein site away from the heme-linked protonation site.	Iodides	150-156	lactoperoxidase	Homo sapiens	53-56
20025541-5	2010	RESULTS: After 48 hours of culture, iodide nearly doubled the mRNA expression levels of the immunity-associated genes (intercellular adhesion molecule-1, transforming growth factor beta 1-induced protein, early growth response gene 1, guanylate-binding protein 1, and annexin A1) and decreased the mRNA expression of sodium-iodide symporter to less than 20%.	Iodides	36-42	intercellular adhesion molecule 1	Homo sapiens	119-187
20053774-1	2010	We examined whether human sodium/iodide symporter (hNIS) radioiodine gene therapy can modulate the phenotype of cancer cells and enhance the killing activities of CTLs in a mouse tumor model.	Iodides	33-39	solute carrier family 5 member 5	Homo sapiens	51-55
20025541-5	2010	RESULTS: After 48 hours of culture, iodide nearly doubled the mRNA expression levels of the immunity-associated genes (intercellular adhesion molecule-1, transforming growth factor beta 1-induced protein, early growth response gene 1, guanylate-binding protein 1, and annexin A1) and decreased the mRNA expression of sodium-iodide symporter to less than 20%.	Iodides	36-42	guanylate binding protein 1	Homo sapiens	235-262
20025541-5	2010	RESULTS: After 48 hours of culture, iodide nearly doubled the mRNA expression levels of the immunity-associated genes (intercellular adhesion molecule-1, transforming growth factor beta 1-induced protein, early growth response gene 1, guanylate-binding protein 1, and annexin A1) and decreased the mRNA expression of sodium-iodide symporter to less than 20%.	Iodides	36-42	annexin A1	Homo sapiens	268-278
20025541-9	2010	The iodide-induced increase in CCL2 was greater in thyroid follicles obtained from thyroid gland that had been moderately infiltrated with the immunocompetent cells.	Iodides	4-10	C-C motif chemokine ligand 2	Homo sapiens	31-35
20025541-10	2010	CONCLUSION: We have demonstrated that iodide stimulates thyroid follicular cells to produce chemokines, particularly CCL2, CXCL8, and CXCL14.	Iodides	38-44	C-C motif chemokine ligand 2	Homo sapiens	117-121
20025541-10	2010	CONCLUSION: We have demonstrated that iodide stimulates thyroid follicular cells to produce chemokines, particularly CCL2, CXCL8, and CXCL14.	Iodides	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
20025541-10	2010	CONCLUSION: We have demonstrated that iodide stimulates thyroid follicular cells to produce chemokines, particularly CCL2, CXCL8, and CXCL14.	Iodides	38-44	C-X-C motif chemokine ligand 14	Homo sapiens	134-140
19780099-1	2009	The Na(+)/I(-) symporter (NIS) mediates iodide uptake in the thyroid gland as well as in other NIS-expressing cells.	Iodides	40-46	solute carrier family 5 member 5	Homo sapiens	4-24
19845388-15	2009	The standard potential of the iodide/triiodide redox couple is 0.35 V (versus the normal hydrogen electrode, NHE), and the oxidation potential of the standard DSC-sensitizer (Ru(dcbpy)(2)(NCS)(2)) is 1.1 V. The driving force for reduction of oxidized dye is therefore as large as 0.75 V. This process leads to the largest internal potential loss in DSC devices.	Iodides	30-36	solute carrier family 9 member C1	Homo sapiens	109-112
19861538-1	2009	The activating mutation BRAF(V600E) is a frequent genetic event in papillary thyroid carcinomas (PTC) that predicts a poor prognosis, leading to loss of sodium/iodide symporter (NIS) expression and subsequent radioiodide-refractory metastatic disease.	Iodides	160-166	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	24-29
19780099-1	2009	The Na(+)/I(-) symporter (NIS) mediates iodide uptake in the thyroid gland as well as in other NIS-expressing cells.	Iodides	40-46	solute carrier family 5 member 5	Homo sapiens	26-29
19605545-0	2009	Role of pendrin in iodide balance: going with the flow.	Iodides	19-25	solute carrier family 26, member 4	Mus musculus	8-15
19557506-6	2009	The results of absorption, ionic strength and iodide ion quenching suggested that the interaction mode of E2 and E3 with ct-DNA was intercalative binding.	Iodides	46-52	dihydrolipoamide branched chain transacylase E2	Bos taurus	106-115
19763292-1	2009	The cross-coupling reaction of diarylamines with aryl bromides/iodides can be effected by the Ni(ii)-(sigma-aryl) complex/PPh(3)/NaH system, and a preliminary investigation was conducted into the mechanism of this reaction.	Iodides	63-70	caveolin 1	Homo sapiens	122-128
19436071-0	2009	Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands.	Iodides	83-89	iodotyrosine deiodinase	Homo sapiens	21-44
19584307-5	2009	One hour of treatment with VIP strongly increased F508del-CFTR activity, with iodide efflux peaks three times higher than with untreated cells.	Iodides	78-84	vasoactive intestinal peptide	Homo sapiens	27-30
19584307-5	2009	One hour of treatment with VIP strongly increased F508del-CFTR activity, with iodide efflux peaks three times higher than with untreated cells.	Iodides	78-84	CF transmembrane conductance regulator	Homo sapiens	58-62
19584307-6	2009	At 37 degrees C, VIP-treated cells, but not untreated controls, showed significant iodide efflux peaks that were sensitive to the CFTR inhibitor 3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone (CFTR(inh)-172).	Iodides	83-89	vasoactive intestinal peptide	Homo sapiens	17-20
19584307-6	2009	At 37 degrees C, VIP-treated cells, but not untreated controls, showed significant iodide efflux peaks that were sensitive to the CFTR inhibitor 3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone (CFTR(inh)-172).	Iodides	83-89	CF transmembrane conductance regulator	Homo sapiens	130-134
19706688-3	2009	We recently reported that PBF inhibits iodide uptake, and have now elucidated a mechanism by which PBF directly modulates sodium iodide symporter (NIS) activity in vitro.	Iodides	39-45	PTTG1 interacting protein	Rattus norvegicus	26-29
19706688-6	2009	Coimmunoprecipitation and GST-pull-down experiments demonstrated a direct interaction between NIS and PBF, the functional consequence of which was assessed using iodide-uptake studies in rat thyroid FRTL-5 cells.	Iodides	162-168	PTTG1 interacting protein	Rattus norvegicus	102-105
19706688-7	2009	PBF repressed iodide uptake, whereas three deletion mutants, which did not localise within intracellular vesicles, lost the ability to inhibit NIS activity.	Iodides	14-20	PTTG1 interacting protein	Rattus norvegicus	0-3
19706688-8	2009	In summary, we present an entirely novel mechanism by which the proto-oncogene PBF binds NIS and alters its subcellular localisation, thereby regulating its ability to uptake iodide.	Iodides	175-181	PTTG1 interacting protein	Rattus norvegicus	79-82
19534545-8	2009	This reaction is viewed as an iodine-induced electron transfer reaction across Co(III)-porphyrinogen, in which the four electrons that originated from the oxidation of the internal reductant (porphyrinogen) to porphodimethene are shared by the internal oxidant (Co(III)), and the external oxidant (iodine), resulting in the reduction to Co(II) and iodide, respectively.	Iodides	348-354	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	79-86
19774621-6	2009	METHODS: Molecular characterization of S1118F-CFTR mutant was studied in HEK-293 cells at 37 degrees C. Various biochemical methods such as Western blotting, real-time PCR, Pulse chase labeling and iodide efflux assay were employed.	Iodides	198-204	CF transmembrane conductance regulator	Homo sapiens	46-50
19436071-1	2009	The flavoprotein iodotyrosine deiodinase (IYD) salvages iodide from mono- and diiodotyrosine formed during the biosynthesis of the thyroid hormone thyroxine.	Iodides	56-62	iodotyrosine deiodinase	Homo sapiens	17-40
19436071-1	2009	The flavoprotein iodotyrosine deiodinase (IYD) salvages iodide from mono- and diiodotyrosine formed during the biosynthesis of the thyroid hormone thyroxine.	Iodides	56-62	iodotyrosine deiodinase	Homo sapiens	42-45
19336661-0	2009	Iodide deficiency-induced angiogenic stimulus in the thyroid occurs via HIF- and ROS-dependent VEGF-A secretion from thyrocytes.	Iodides	0-6	vascular endothelial growth factor A	Homo sapiens	95-101
19429184-2	2009	The SLC26A4 gene is expressed at the apical surface of thyrocytes and its product forms an efficient iodide-trapping mechanism.	Iodides	101-107	solute carrier family 26 member 4	Homo sapiens	4-11
19241193-1	2009	The sodium iodide symporter (NIS) present in the membranes of thyroid cells is responsible for the capacity of the thyroid to concentrate iodide.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
19525464-3	2009	Furthermore, recent in vitro studies indicate that (131)I irradiation reduces iodide uptake by downregulating the expression of the sodium iodide symporter (NIS).	Iodides	78-84	solute carrier family 5 member 5	Homo sapiens	157-160
19196796-8	2009	The data suggest that whereas D1 and D2 are not essential for the maintenance of the serum T(3) level, they do serve important roles in thyroid hormone homeostasis, the D2 being critical for local T(3) production and the D1 playing an important role in iodide conservation by serving as a scavenger enzyme in peripheral tissues and the thyroid.	Iodides	253-259	deiodinase, iodothyronine, type I	Mus musculus	30-39
19237432-12	2009	SiRNA-mediated silencing of hBest1 in CFPAC-1 cells reduced the UTP-stimulated iodide efflux by around 40%.	Iodides	79-85	bestrophin 1	Homo sapiens	28-34
19152441-0	2009	High prevalence of BRAF mutation in a Brazilian cohort of patients with sporadic papillary thyroid carcinomas: correlation with more aggressive phenotype and decreased expression of iodide-metabolizing genes.	Iodides	182-188	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	19-23
18500672-1	2009	The Na(+)/I(-) symporter (NIS) is a transmembrane glycoprotein that mediates iodide uptake into thyroid follicular cells and serves as the molecular basis of radioiodine imaging and therapy for thyroid cancer patients.	Iodides	77-83	solute carrier family 5 member 5	Homo sapiens	4-24
18500672-1	2009	The Na(+)/I(-) symporter (NIS) is a transmembrane glycoprotein that mediates iodide uptake into thyroid follicular cells and serves as the molecular basis of radioiodine imaging and therapy for thyroid cancer patients.	Iodides	77-83	solute carrier family 5 member 5	Homo sapiens	26-29
19366229-2	2009	On the basis of the electrochemical and spectroelectrochemical behavior of thin films of TTF over a glassy carbon electrode in iodide media, a new, more complete mechanism for the electrode processes involved is proposed.	Iodides	127-133	ras homolog family member H	Homo sapiens	89-92
19052257-0	2009	The Na+/I- symporter mediates active iodide uptake in the intestine.	Iodides	37-43	solute carrier family 5 member 5	Rattus norvegicus	4-20
19152441-10	2009	CONCLUSIONS: These findings provide further evidence that BRAF might be associated with a more aggressive phenotype and less differentiated state due to decreased expression of iodide-metabolizing genes.	Iodides	177-183	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	58-62
19098211-12	2009	RESULTS: Infection of human pancreatic cancer cell lines with MV-NIS in vitro resulted in syncytia formation, marked iodide uptake, and ultimately cell death.	Iodides	117-123	solute carrier family 5 member 5	Homo sapiens	65-68
19196800-0	2009	Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid.	Iodides	23-29	solute carrier family 5 member 5	Homo sapiens	40-43
19196800-3	2009	Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane glycoprotein, the sodium-iodide symporter (NIS), which actively cotransports two sodium cations per each iodide anion.	Iodides	10-16	solute carrier family 5 member 5	Homo sapiens	117-120
19196800-3	2009	Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane glycoprotein, the sodium-iodide symporter (NIS), which actively cotransports two sodium cations per each iodide anion.	Iodides	179-191	solute carrier family 5 member 5	Homo sapiens	117-120
19196800-4	2009	NIS-mediated transport of iodide is driven by the electrochemical sodium gradient generated by the Na(+)/K(+)-ATPase.	Iodides	26-32	solute carrier family 5 member 5	Homo sapiens	0-3
19196800-6	2009	TSH and iodide regulate iodide accumulation by modulating NIS activity via transcriptional and posttranscriptional mechanisms.	Iodides	8-14	solute carrier family 5 member 5	Homo sapiens	58-61
19196800-6	2009	TSH and iodide regulate iodide accumulation by modulating NIS activity via transcriptional and posttranscriptional mechanisms.	Iodides	24-30	solute carrier family 5 member 5	Homo sapiens	58-61
19196800-7	2009	Biallelic mutations in the NIS gene lead to a congenital iodide transport defect, an autosomal recessive condition characterized by hypothyroidism, goiter, low thyroid iodide uptake, and a low saliva/plasma iodide ratio.	Iodides	57-63	solute carrier family 5 member 5	Homo sapiens	27-30
19196800-9	2009	Biallelic mutations in the SLC26A4 gene lead to Pendred syndrome, an autosomal recessive disorder characterized by sensorineural deafness, goiter, and impaired iodide organification.	Iodides	160-166	solute carrier family 26 member 4	Homo sapiens	27-34
19196800-11	2009	Functional in vitro data and the impaired iodide organification observed in patients with Pendred syndrome support a role of pendrin as an apical iodide transporter.	Iodides	42-48	solute carrier family 26 member 4	Homo sapiens	125-132
19265500-2	2009	The aim of this study was to clarify these conflicting results by examining if prolonged high iodide exposition with or without interferon (IFN)-gamma has an effect on human primary thyroid cell proliferation, thyroglobulin (Tg) production, and intercellular adhesion molecule-1 (ICAM-1) and human leukocyte antigen (HLA)-DR expression.	Iodides	94-100	thyroglobulin	Homo sapiens	210-223
19265500-2	2009	The aim of this study was to clarify these conflicting results by examining if prolonged high iodide exposition with or without interferon (IFN)-gamma has an effect on human primary thyroid cell proliferation, thyroglobulin (Tg) production, and intercellular adhesion molecule-1 (ICAM-1) and human leukocyte antigen (HLA)-DR expression.	Iodides	94-100	intercellular adhesion molecule 1	Homo sapiens	245-278
19265500-12	2009	CONCLUSIONS: Augmented ICAM-1 in the presence of iodide excess and low-dose IFN-gamma could induce secretion of proinflammatory cytokines and lymphocytic infiltration in the thyroid gland.	Iodides	49-55	intercellular adhesion molecule 1	Homo sapiens	23-29
19265500-13	2009	Decreased Tg production in the presence of KI excess and IFN-gamma could explain the development of hypothyroidism after adding iodide in a diet of subjects that already have lymphocytic infiltration and/or mild inflammation in the thyroid gland.	Iodides	128-134	interferon gamma	Homo sapiens	57-66
19050049-1	2009	CONTEXT: Pendrin is an apical protein of thyroid follicular cells, responsible for the efflux of iodide into the follicular lumen via an iodide-chloride transport mechanism.	Iodides	97-103	solute carrier family 26 member 4	Homo sapiens	9-16
19050049-1	2009	CONTEXT: Pendrin is an apical protein of thyroid follicular cells, responsible for the efflux of iodide into the follicular lumen via an iodide-chloride transport mechanism.	Iodides	137-143	solute carrier family 26 member 4	Homo sapiens	9-16
19029227-1	2009	OBJECTIVE: The active transport of iodide into thyroid cells is mediated by the Na(+)/I(-) symporter (NIS) located in the basolateral membrane.	Iodides	35-41	solute carrier family 5 member 5	Homo sapiens	80-100
19029227-1	2009	OBJECTIVE: The active transport of iodide into thyroid cells is mediated by the Na(+)/I(-) symporter (NIS) located in the basolateral membrane.	Iodides	35-41	solute carrier family 5 member 5	Homo sapiens	102-105
19061388-1	2009	Thermal dissociation of CO from cis,fac-[Ir(CO)(2)I(3)Me](-) (1a) gives the iodide-bridged dimer [{Ir(CO)I(2)(mu-I)Me}(2)](2-), which was characterized crystallographically as its Ph(4)As(+) salt.	Iodides	76-82	FA complementation group C	Homo sapiens	36-39
18534903-13	2008	The diamagnetic nature for three of the five iodide complexes, prepared by tribochemical reactions, suggests the oxidation of CoII to CoIII ion and the existence of low spin-octahedral geometry around the CoIII ion.	Iodides	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-130
19331152-9	2009	CONCLUSION: Transduction of the hNIS gene controlled by the novel EIIAPA chimeric promoter successfully induces iodide transport in hepatoma.	Iodides	112-118	solute carrier family 5 member 5	Homo sapiens	32-36
19350818-2	2009	A stably transfected Fischer rat thyroid (FRT) epithelial cell lines co-expressing human CFTR and a green fluorescent protein mutant with ultra-high halide sensitivity (EYFP) were used to measure CFTR-mediated iodide influx rates.	Iodides	210-216	CF transmembrane conductance regulator	Homo sapiens	196-200
18534903-6	2008	The ligands (L1", L2" and L3") formed by tribochemical reactions are quite similar to these of L1, L2 and L3, except that the ionizable chloride ions in case of L1, L2 and L3 are substituted by iodide ions in (L1", L2" and L3").	Iodides	194-200	L1 cell adhesion molecule	Homo sapiens	95-108
18534903-6	2008	The ligands (L1", L2" and L3") formed by tribochemical reactions are quite similar to these of L1, L2 and L3, except that the ionizable chloride ions in case of L1, L2 and L3 are substituted by iodide ions in (L1", L2" and L3").	Iodides	194-200	L1 cell adhesion molecule	Homo sapiens	161-174
18534903-9	2008	On the other hand, the IR spectra of the iodide CoII and CoIII complexes, synthesized by tribochemical reactions, suggest that L1" behaves only in a bidentate fashion via NH1 and CS groups.	Iodides	41-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
18534903-13	2008	The diamagnetic nature for three of the five iodide complexes, prepared by tribochemical reactions, suggests the oxidation of CoII to CoIII ion and the existence of low spin-octahedral geometry around the CoIII ion.	Iodides	45-51	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	134-139
18534903-13	2008	The diamagnetic nature for three of the five iodide complexes, prepared by tribochemical reactions, suggests the oxidation of CoII to CoIII ion and the existence of low spin-octahedral geometry around the CoIII ion.	Iodides	45-51	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	205-210
18534903-14	2008	Finally, the results of the rest of the iodide CoII complexes suggest either tetrahedral and/or high-spin octahedral geometry.	Iodides	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
18708479-1	2008	The sodium/iodide symporter (SLC5A5; also known as NIS), a transmembrane glycoprotein principally in the thyroid gland, is responsible for the accumulation of iodide necessary for thyroid hormones.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-35
18708479-1	2008	The sodium/iodide symporter (SLC5A5; also known as NIS), a transmembrane glycoprotein principally in the thyroid gland, is responsible for the accumulation of iodide necessary for thyroid hormones.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	51-54
18708479-8	2008	These findings suggested that the decreased levels of iodide uptake activity of SLC5A5 mutants resulted from lower catalytic rates.	Iodides	54-60	solute carrier family 5 member 5	Homo sapiens	80-86
18708479-1	2008	The sodium/iodide symporter (SLC5A5; also known as NIS), a transmembrane glycoprotein principally in the thyroid gland, is responsible for the accumulation of iodide necessary for thyroid hormones.	Iodides	159-165	solute carrier family 5 member 5	Homo sapiens	29-35
18708479-9	2008	In conclusion, our data first identified the involvement of extracellular charged amino acid residue in the iodide uptake ability of SLC5A5.	Iodides	108-114	solute carrier family 5 member 5	Homo sapiens	133-139
18708479-1	2008	The sodium/iodide symporter (SLC5A5; also known as NIS), a transmembrane glycoprotein principally in the thyroid gland, is responsible for the accumulation of iodide necessary for thyroid hormones.	Iodides	159-165	solute carrier family 5 member 5	Homo sapiens	51-54
18708479-2	2008	Our previous study indicated that a novel exon 6 deletion (residues 233-280) in SLC5A5 loses the iodide uptake activity.	Iodides	97-103	solute carrier family 5 member 5	Homo sapiens	80-86
18708479-3	2008	Herein we characterized the role of His-226 in iodide transport of SLC5A5.	Iodides	47-53	solute carrier family 5 member 5	Homo sapiens	67-73
18692402-3	2008	Pendred syndrome is caused by biallelic mutations in the SLC26A4 gene, which encodes pendrin, a transporter of chloride, bicarbonate and iodide.	Iodides	137-143	solute carrier family 26 member 4	Homo sapiens	57-64
18762555-9	2008	Inhibition of the PI3K pathway also significantly increased iodide uptake ( approximately 3.5-fold) in BHP 2-7 papillary thyroid cancer cells (Ret/PTC1 positive), engineered to constitutively express NIS.	Iodides	60-66	ret proto-oncogene	Homo sapiens	143-146
18762555-9	2008	Inhibition of the PI3K pathway also significantly increased iodide uptake ( approximately 3.5-fold) in BHP 2-7 papillary thyroid cancer cells (Ret/PTC1 positive), engineered to constitutively express NIS.	Iodides	60-66	patched 1	Homo sapiens	147-151
18459119-1	2008	We studied the expression and the hormonal regulation of the PDS gene product, pendrin, which is, in thyrocytes, responsible for the iodide transport out of the cell.	Iodides	133-139	solute carrier family 26 member 4	Rattus norvegicus	79-86
18986218-1	2008	INTRODUCTION: We conducted a molecular imaging and gene therapy method in alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) by tumor-specific expression of the human sodium/iodide symporter (hNIS) using an AFP promoter.	Iodides	188-194	alpha fetoprotein	Homo sapiens	74-91
18986218-1	2008	INTRODUCTION: We conducted a molecular imaging and gene therapy method in alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) by tumor-specific expression of the human sodium/iodide symporter (hNIS) using an AFP promoter.	Iodides	188-194	alpha fetoprotein	Homo sapiens	93-96
18986218-1	2008	INTRODUCTION: We conducted a molecular imaging and gene therapy method in alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) by tumor-specific expression of the human sodium/iodide symporter (hNIS) using an AFP promoter.	Iodides	188-194	HCC	Homo sapiens	134-137
30290408-3	2008	SLC26A4 encodes pendrin, a sodium-independent transporter of iodide/chloride, chloride/formate and bicarbonate, that is expressed in the inner ear, thyroid gland, syncytiotrophoblast cells, endometrium and kidney.	Iodides	61-67	solute carrier family 26 member 4	Homo sapiens	0-7
30290408-3	2008	SLC26A4 encodes pendrin, a sodium-independent transporter of iodide/chloride, chloride/formate and bicarbonate, that is expressed in the inner ear, thyroid gland, syncytiotrophoblast cells, endometrium and kidney.	Iodides	61-67	solute carrier family 26 member 4	Homo sapiens	16-23
18692402-3	2008	Pendred syndrome is caused by biallelic mutations in the SLC26A4 gene, which encodes pendrin, a transporter of chloride, bicarbonate and iodide.	Iodides	137-143	solute carrier family 26 member 4	Homo sapiens	85-92
18692402-4	2008	This review discusses the controversies surrounding the potential role of pendrin in mediating apical iodide efflux into the lumen of thyroid follicles, and discusses its functional role in the kidney and the inner ear.	Iodides	102-108	solute carrier family 26 member 4	Homo sapiens	74-81
18645607-6	2008	Quantitative RT-PCR confirmed the array data demonstrating that iodine/iodide treatment increased the mRNA levels of several genes involved in estrogen metabolism (CYP1A1, CYP1B1, and AKR1C1) while decreasing the levels of the estrogen responsive genes TFF1 and WISP2.	Iodides	71-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	164-170
18430055-8	2008	Dose-dependent potentiation of defective DeltaF508-CFTR chloride channel gating by five coumarin compounds was demonstrated by the fluorescent iodide influx assay and confirmed by an Ussing chamber short-circuit current assay.	Iodides	143-149	CF transmembrane conductance regulator	Rattus norvegicus	51-55
18470848-0	2008	Enhanced iodide sequestration by 3-biphenyl-5,6-dihydroimidazo[2,1-b]thiazole in sodium/iodide symporter (NIS)-expressing cells.	Iodides	9-15	solute carrier family 5 member 5	Homo sapiens	106-109
18470848-0	2008	Enhanced iodide sequestration by 3-biphenyl-5,6-dihydroimidazo[2,1-b]thiazole in sodium/iodide symporter (NIS)-expressing cells.	Iodides	88-94	solute carrier family 5 member 5	Homo sapiens	106-109
18470848-1	2008	The ability of the sodium/iodide symporter (NIS) to take up iodide has long provided the basis for cytoreductive gene therapy and cancer treatment with radioiodide.	Iodides	26-32	solute carrier family 5 member 5	Homo sapiens	44-47
18470848-3	2008	We identified and characterized a small organic molecule capable of increasing iodide retention in HEK293 cells permanently transfected with human NIS cDNA (hNIS-HEK293) and in the rat thyroid-derived cell line FRTL-5.	Iodides	79-85	solute carrier family 5 member 5	Homo sapiens	147-150
18470848-6	2008	This new compound is not only an attractive chemical tool to investigate the mechanisms of iodide flux at the cellular level, but also opens promising perspectives in the treatment of cancer after NIS gene transfer.	Iodides	91-97	solute carrier family 5 member 5	Homo sapiens	197-200
18585294-5	2008	Dissolved organic carbon, chloride and iodide ions are tolerated in concentrations of 15 mg DOC l(-1), &gt;21 g Cl(-)l(-1), and 10 mg I(-)l(-1).	Iodides	39-45	collectin subfamily member 10	Homo sapiens	112-121
18645607-6	2008	Quantitative RT-PCR confirmed the array data demonstrating that iodine/iodide treatment increased the mRNA levels of several genes involved in estrogen metabolism (CYP1A1, CYP1B1, and AKR1C1) while decreasing the levels of the estrogen responsive genes TFF1 and WISP2.	Iodides	71-77	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	172-178
18645607-6	2008	Quantitative RT-PCR confirmed the array data demonstrating that iodine/iodide treatment increased the mRNA levels of several genes involved in estrogen metabolism (CYP1A1, CYP1B1, and AKR1C1) while decreasing the levels of the estrogen responsive genes TFF1 and WISP2.	Iodides	71-77	aldo-keto reductase family 1 member C1	Homo sapiens	184-190
18645607-6	2008	Quantitative RT-PCR confirmed the array data demonstrating that iodine/iodide treatment increased the mRNA levels of several genes involved in estrogen metabolism (CYP1A1, CYP1B1, and AKR1C1) while decreasing the levels of the estrogen responsive genes TFF1 and WISP2.	Iodides	71-77	trefoil factor 1	Homo sapiens	253-257
18645607-6	2008	Quantitative RT-PCR confirmed the array data demonstrating that iodine/iodide treatment increased the mRNA levels of several genes involved in estrogen metabolism (CYP1A1, CYP1B1, and AKR1C1) while decreasing the levels of the estrogen responsive genes TFF1 and WISP2.	Iodides	71-77	cellular communication network factor 5	Homo sapiens	262-267
18202121-1	2008	The lack of Na(+)/I(-) symporter (NIS) gene expression in some thyroid cancer patients has been a major hurdle that limits the efficacy of standard radioactive iodide therapy.	Iodides	160-166	solute carrier family 5 member 5	Homo sapiens	12-32
18538122-2	2008	The Pendred syndrome gene (SLC26A4) encodes a new anion exchanger named pendrin which mediates iodide transport by thyrocytes and regulates ion and fluid transport by the endolymphatic sac epithelium.	Iodides	95-101	solute carrier family 26 member 4	Homo sapiens	27-34
18538122-2	2008	The Pendred syndrome gene (SLC26A4) encodes a new anion exchanger named pendrin which mediates iodide transport by thyrocytes and regulates ion and fluid transport by the endolymphatic sac epithelium.	Iodides	95-101	solute carrier family 26 member 4	Homo sapiens	72-79
18322141-1	2008	Pendrin, a Cl(-)/anion exchanger encoded by the gene PDS, is highly expressed in the kidney, thyroid, and inner ear epithelia and is essential for bicarbonate secretion, iodide accumulation, and endolymph ion balance, respectively.	Iodides	170-176	solute carrier family 26 member 4	Homo sapiens	0-7
18322141-1	2008	Pendrin, a Cl(-)/anion exchanger encoded by the gene PDS, is highly expressed in the kidney, thyroid, and inner ear epithelia and is essential for bicarbonate secretion, iodide accumulation, and endolymph ion balance, respectively.	Iodides	170-176	solute carrier family 26 member 4	Homo sapiens	53-56
18202121-1	2008	The lack of Na(+)/I(-) symporter (NIS) gene expression in some thyroid cancer patients has been a major hurdle that limits the efficacy of standard radioactive iodide therapy.	Iodides	160-166	solute carrier family 5 member 5	Homo sapiens	34-37
18404268-1	2008	PURPOSE: We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)I.	Iodides	57-63	kallikrein related peptidase 3	Homo sapiens	107-138
18404268-1	2008	PURPOSE: We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)I.	Iodides	57-63	solute carrier family 5 member 5	Homo sapiens	182-185
18241232-1	2008	Intracellular adhesion molecule-1 (ICAM-1) expression on the thyroid follicular cells of non-obese diabetic (NOD).H2(h4) mice is enhanced by iodide treatment, which correlates with autoimmune thyroid disease in genetically susceptible NOD.H2(h4) mice.	Iodides	141-147	intercellular adhesion molecule 1	Mus musculus	0-33
18319322-0	2008	Retinoic acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is mediated by the insulin growth factor-I/phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase signaling pathways.	Iodides	40-46	mitogen-activated protein kinase 14	Homo sapiens	163-166
18319322-7	2008	Inhibitors of the IGF-I receptor, Janus kinase, and phosphatidylinositol 3-kinase (PI3K), significantly reduced NIS mRNA expression and iodide uptake in tRA-stimulated MCF-7 cells but not FRTL-5 cells.	Iodides	136-142	insulin like growth factor 1 receptor	Homo sapiens	18-32
18319322-8	2008	An inhibitor of p38 MAPK significantly reduced iodide uptake in both tRA-stimulated MCF-7 cells and TSH-stimulated FRTL-5 cells.	Iodides	47-53	mitogen-activated protein kinase 14	Homo sapiens	16-19
18307189-1	2008	The Na(+)/I(-) symporter (NIS) mediates iodide uptake into thyroid follicular cells.	Iodides	40-46	solute carrier family 5 member 5	Homo sapiens	4-24
18307189-1	2008	The Na(+)/I(-) symporter (NIS) mediates iodide uptake into thyroid follicular cells.	Iodides	40-46	solute carrier family 5 member 5	Homo sapiens	26-29
18283639-1	2008	The expression of the Na/I Symporter (NIS) in the basolateral cell membrane of the thyroid follicular cells is responsible for the active accumulation of iodide within the thyroid gland and for the subsequent biosynthesis of thyroid hormones.	Iodides	154-160	solute carrier family 5 member 5	Homo sapiens	22-36
18283639-1	2008	The expression of the Na/I Symporter (NIS) in the basolateral cell membrane of the thyroid follicular cells is responsible for the active accumulation of iodide within the thyroid gland and for the subsequent biosynthesis of thyroid hormones.	Iodides	154-160	solute carrier family 5 member 5	Homo sapiens	38-41
18434651-1	2008	DEHAL1 has been identified as the gene encoding iodotyrosine deiodinase in the thyroid, where it controls the reuse of iodide for thyroid hormone synthesis.	Iodides	119-125	iodotyrosine deiodinase	Homo sapiens	0-6
18064720-7	2008	The significant increase in the concentration of iodide protein-bound fraction, which was observed simultaneously with TPO inhibition, could be due to thyroglobulin non-enzymic iodination under H(2)O(2)-generated oxidative stress.	Iodides	49-55	thyroid peroxidase	Rattus norvegicus	119-122
18241232-1	2008	Intracellular adhesion molecule-1 (ICAM-1) expression on the thyroid follicular cells of non-obese diabetic (NOD).H2(h4) mice is enhanced by iodide treatment, which correlates with autoimmune thyroid disease in genetically susceptible NOD.H2(h4) mice.	Iodides	141-147	intercellular adhesion molecule 1	Mus musculus	35-41
17989705-9	2008	In conclusion, tumor-specific iodide accumulation was induced in HCC cells by AFP promoter-directed NIS expression in vitro and in vivo, which was sufficiently high to allow a therapeutic effect of (131)I.	Iodides	30-36	alpha fetoprotein	Homo sapiens	78-81
18272324-5	2008	We also showed that iodide excess inhibits the expression of essential genes for thyroid differentiation: Tshr, Nis, Tg, and Tpo.	Iodides	20-26	thyroid stimulating hormone receptor	Rattus norvegicus	106-110
18272324-5	2008	We also showed that iodide excess inhibits the expression of essential genes for thyroid differentiation: Tshr, Nis, Tg, and Tpo.	Iodides	20-26	thyroid peroxidase	Rattus norvegicus	125-128
17690331-7	2008	The iodide efflux seen with 8-iso-PGE(2) is abolished by the EP(4) receptor antagonist AH23848, the CFTR inhibitor 172, and inhibition of PKA and the PI3K pathway.	Iodides	4-10	CF transmembrane conductance regulator	Homo sapiens	100-104
18372236-1	2008	The active transport of iodide from the bloodstream into thyroid follicular cells is mediated by the Na+/I- symporter (NIS).	Iodides	24-30	solute carrier family 5 member 5	Homo sapiens	101-117
18357551-1	2008	Thyroxine (T4), the main secretory hormone of the thyroid gland, is produced on thyroglobulin by thyroid peroxidase (TPO)/H(2)O(2)/iodide system and deiodinated to its active form (T3) by a selenocysteine-containing enzyme, iodothyronine deiodinase (ID).	Iodides	131-137	thyroid peroxidase	Homo sapiens	117-120
17913707-1	2007	The Na+/I- symporter (NIS)-mediated iodide uptake activity is the basis for targeted radioiodide ablation of thyroid cancers.	Iodides	36-42	solute carrier family 5 member 5	Homo sapiens	4-20
17654517-5	2008	The presence of functional CFTR was confirmed using iodide efflux assay.	Iodides	52-58	CF transmembrane conductance regulator	Homo sapiens	27-31
17938956-12	2008	When apoplastic coupling was minimised by exogenous application of peroxidase-blockers (iodide, dithiothreitol and cysteine), a higher proportion of the secreted [14C]feruloyl-polysaccharides was sloughed into the medium.	Iodides	88-94	peroxidase 1	Zea mays	67-77
17913707-4	2007	Kinetic analysis of NIS mutants of the corresponding phosphorylated amino acid residue indicated that the velocity of iodide transport of NIS is modulated by the phosphorylation status of Ser-43 and Ser-581.	Iodides	118-124	solute carrier family 5 member 5	Homo sapiens	20-23
17913707-4	2007	Kinetic analysis of NIS mutants of the corresponding phosphorylated amino acid residue indicated that the velocity of iodide transport of NIS is modulated by the phosphorylation status of Ser-43 and Ser-581.	Iodides	118-124	solute carrier family 5 member 5	Homo sapiens	138-141
17913707-1	2007	The Na+/I- symporter (NIS)-mediated iodide uptake activity is the basis for targeted radioiodide ablation of thyroid cancers.	Iodides	36-42	solute carrier family 5 member 5	Homo sapiens	22-25
17898794-6	2007	We also confirmed the functional channel activity of GFP-CFTR in an iodide efflux assay.	Iodides	68-74	CF transmembrane conductance regulator	Homo sapiens	57-61
17596272-8	2007	Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172.	Iodides	94-100	CF transmembrane conductance regulator	Rattus norvegicus	162-166
18217604-1	2007	Enynes bearing an iodide (bromide) at their alkyne terminus react with catalytic amounts of [Cp*Ru(MeCN)3]PF6 in DMF to give strained iodo(bromo)cyclobutene derivatives in good to excellent yields.	Iodides	18-24	sperm associated antigen 17	Homo sapiens	106-109
17761422-5	2007	The best hCA VB inhibitors were cyanate, thiocyanate, cyanide and hydrogensulfide (K(I)s of 80-76 microM) whereas the least effective ones were the halides (K(I)s of 11-72 mM), with the best inhibitor being fluoride and the least effective ones bromide and iodide.	Iodides	257-263	carbonic anhydrase 5B	Homo sapiens	9-15
17936696-6	2007	Comparative data of ibPrx15 on substrate specificity to tobacco anionic peroxidase (TOP) and horseradish peroxidase (HRP) reveal similar specific activity towards a series of conventional substrates except for iodide, which is a two-electron donor interacting directly with the compound I derivative in the catalytic cycle.	Iodides	210-216	lignin-forming anionic peroxidase-like	Nicotiana tabacum	72-82
17936696-7	2007	ibPrx15 exhibits a high specific activity towards iodide about 10(3)-fold to that of tobacco peroxidase.	Iodides	50-56	lignin-forming anionic peroxidase-like	Nicotiana tabacum	93-103
17596272-8	2007	Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172.	Iodides	220-226	CF transmembrane conductance regulator	Rattus norvegicus	187-191
17596272-8	2007	Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172.	Iodides	220-226	CF transmembrane conductance regulator	Rattus norvegicus	187-191
17596272-8	2007	Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172.	Iodides	94-100	CF transmembrane conductance regulator	Rattus norvegicus	187-191
17596272-8	2007	Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172.	Iodides	94-100	CF transmembrane conductance regulator	Rattus norvegicus	187-191
17596272-8	2007	Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172.	Iodides	94-100	CF transmembrane conductance regulator	Rattus norvegicus	187-191
17596272-8	2007	Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172.	Iodides	220-226	CF transmembrane conductance regulator	Rattus norvegicus	162-166
17596272-8	2007	Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172.	Iodides	220-226	CF transmembrane conductance regulator	Rattus norvegicus	187-191
18167272-1	2007	OBJECTIVE: To clone human mucin 1 (MUC1) gene promoter and apply to drive human sodium/iodide symporter (hNIS) gene targeting expression in pancreatic carcinoma cells.	Iodides	87-93	mucin 1, cell surface associated	Homo sapiens	26-33
17698909-1	2007	CONTEXT: We reported recently the induction of iodide accumulation in prostate cancer cells (LNCaP) by prostate-specific antigen promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)iodine ((131)I).	Iodides	47-53	solute carrier family 5 member 5	Homo sapiens	172-175
17698909-2	2007	These data demonstrated the potential of the NIS gene as a novel therapeutic gene, although in some extrathyroidal tumors, therapeutic efficacy may be limited by rapid iodide efflux due to a lack of iodide organification.	Iodides	168-174	solute carrier family 5 member 5	Homo sapiens	45-48
17698909-2	2007	These data demonstrated the potential of the NIS gene as a novel therapeutic gene, although in some extrathyroidal tumors, therapeutic efficacy may be limited by rapid iodide efflux due to a lack of iodide organification.	Iodides	199-205	solute carrier family 5 member 5	Homo sapiens	45-48
18167272-1	2007	OBJECTIVE: To clone human mucin 1 (MUC1) gene promoter and apply to drive human sodium/iodide symporter (hNIS) gene targeting expression in pancreatic carcinoma cells.	Iodides	87-93	mucin 1, cell surface associated	Homo sapiens	35-39
18167272-1	2007	OBJECTIVE: To clone human mucin 1 (MUC1) gene promoter and apply to drive human sodium/iodide symporter (hNIS) gene targeting expression in pancreatic carcinoma cells.	Iodides	87-93	solute carrier family 5 member 5	Homo sapiens	105-109
17515401-4	2007	Iodide uptake assays showed accumulation of radioactive iodide in VSV(Delta51)-NIS-infected myeloma cells that was specific to the function of the NIS transgene.	Iodides	0-6	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	79-82
17726079-5	2007	OBJECTIVES AND METHODS: The objectives were to examine effects of iodide on expression of NIS and hCG in BeWo choriocarcinoma cells.	Iodides	66-72	hypertrichosis 2 (generalised, congenital)	Homo sapiens	98-101
17931047-7	2007	We conclude that a therapeutic effect of (131)I was demonstrated in vivo in MTC cell xenografts after adenovirus-mediated induction of tumor-specific iodide accumulation by CEA promoter-directed hNIS expression.	Iodides	150-156	CEA cell adhesion molecule 3	Homo sapiens	173-176
17931047-7	2007	We conclude that a therapeutic effect of (131)I was demonstrated in vivo in MTC cell xenografts after adenovirus-mediated induction of tumor-specific iodide accumulation by CEA promoter-directed hNIS expression.	Iodides	150-156	solute carrier family 5 member 5	Homo sapiens	195-199
17826032-0	2007	CD4+CD25+ naturally occurring regulatory T cells and not lymphopenia play a role in the pathogenesis of iodide-induced autoimmune thyroiditis in NOD-H2h4 mice.	Iodides	104-110	CD4 antigen	Mus musculus	0-3
17900225-2	2007	Evolutionary pressure has sculpted Tg into a large molecular scaffolding to allow organification of iodide and its incorporation into thyroid hormones.	Iodides	100-106	thyroglobulin	Homo sapiens	35-37
17532758-1	2007	CONTEXT: Thyroid dyshormonogenesis is associated with mutations in the thyroglobulin (TG) gene and characterized by normal organification of iodide and low serum TG.	Iodides	141-147	thyroglobulin	Homo sapiens	71-84
17532758-1	2007	CONTEXT: Thyroid dyshormonogenesis is associated with mutations in the thyroglobulin (TG) gene and characterized by normal organification of iodide and low serum TG.	Iodides	141-147	thyroglobulin	Homo sapiens	86-88
17318546-12	2007	Perchlorate test revealed a total iodide organification defect in two patients, including one with a neonatal diagnosis of Pendred"s syndrome, who were subsequently found to harbour TPO mutations.	Iodides	34-40	thyroid peroxidase	Homo sapiens	182-185
17826032-0	2007	CD4+CD25+ naturally occurring regulatory T cells and not lymphopenia play a role in the pathogenesis of iodide-induced autoimmune thyroiditis in NOD-H2h4 mice.	Iodides	104-110	interleukin 2 receptor, alpha chain	Mus musculus	4-8
17458906-13	2007	TPA effects on iodide metabolism, dissolution of follicles and uPA synthesis are mediated predominantly through PKCbeta whereas EGF exerts its effects through MAPK but not PKCbeta.	Iodides	15-21	plasminogen activator, tissue type	Homo sapiens	0-3
17695547-2	2007	This study aims to restore the iodide uptake by transferring and expressing human sodium iodide symporter (hNIS) in these cancer cells for 131I gene therapy.	Iodides	31-37	solute carrier family 5 member 5	Homo sapiens	107-111
17683742-1	2007	Ultrasonic oxidation of iodide was investigated in the presence of carbon tetrachloride (CCl4).	Iodides	24-30	C-C motif chemokine ligand 4	Homo sapiens	89-93
17683742-3	2007	The ultrasonic oxidation of iodide was found to be significantly promoted by a small addition of CCl4, and it was further found that the generation rate was increased with the amount of CCl4 added.	Iodides	28-34	C-C motif chemokine ligand 4	Homo sapiens	97-101
17683742-3	2007	The ultrasonic oxidation of iodide was found to be significantly promoted by a small addition of CCl4, and it was further found that the generation rate was increased with the amount of CCl4 added.	Iodides	28-34	C-C motif chemokine ligand 4	Homo sapiens	186-190
17547680-1	2007	BACKGROUND: Iodide organification defects are frequently but not always associated with mutations in the thyroid peroxidase (TPO) gene and characterized by a positive perchlorate discharge test.	Iodides	12-18	thyroid peroxidase	Homo sapiens	105-123
17547680-1	2007	BACKGROUND: Iodide organification defects are frequently but not always associated with mutations in the thyroid peroxidase (TPO) gene and characterized by a positive perchlorate discharge test.	Iodides	12-18	thyroid peroxidase	Homo sapiens	125-128
17611400-4	2007	In vitro iodide uptake and efflux were measured in CT26-hNIS cells at various time points.	Iodides	9-15	solute carrier family 5 member 5	Homo sapiens	56-60
17891230-3	2007	However, the studies related to the mechanisms of iodide transport were only possible after the cloning of the gene that encodes the sodium/iodide symporter (NIS).	Iodides	50-56	solute carrier family 5 member 5	Homo sapiens	158-161
17611400-8	2007	The iodide uptakes of CT26-hNIS tumors were 10-fold greater than those of CT26 tumors.	Iodides	4-10	solute carrier family 5 member 5	Homo sapiens	27-31
17359937-5	2007	Compared with wild-type recombinant MPO the cyanide association rate with ferric Met243Val was significantly enhanced as were also the calculated apparent bimolecular compound I reduction rates by iodide (&gt;10(8) M(-1)s(-1)) and thiocyanate (&gt;10(8) M(-1)s(-1)).	Iodides	197-203	myeloperoxidase	Homo sapiens	36-39
17696829-1	2007	OBJECTIVE: Nonfunctioning thyroid nodules (NFTNs) display a diminished iodide-concentrating ability, owing to defective expression and cell membrane targeting of the sodium-iodide symporter (NIS).	Iodides	71-77	solute carrier family 5 member 5	Homo sapiens	191-194
17297475-4	2007	We now show that PTTG and its binding factor PBF repress expression of sodium iodide symporter (NIS) messenger RNA (mRNA), and inhibit iodide uptake.	Iodides	78-84	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	17-21
17297475-4	2007	We now show that PTTG and its binding factor PBF repress expression of sodium iodide symporter (NIS) messenger RNA (mRNA), and inhibit iodide uptake.	Iodides	78-84	PTTG1 interacting protein	Homo sapiens	45-48
17639055-1	2007	The Na(+)/I(-) symporter (NIS)-mediated iodide uptake is the basis for targeted radioiodine ablation of thyroid cancers.	Iodides	40-46	solute carrier family 5 member 5	Homo sapiens	4-24
17639055-1	2007	The Na(+)/I(-) symporter (NIS)-mediated iodide uptake is the basis for targeted radioiodine ablation of thyroid cancers.	Iodides	40-46	solute carrier family 5 member 5	Homo sapiens	26-29
17322488-1	2007	UNLABELLED: Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide in the human thyroid.	Iodides	105-111	iodotyrosine deiodinase	Homo sapiens	12-39
17430051-0	2007	Molecular mechanism of transporting a polarizable iodide anion across the water-CCl4 liquid/liquid interface.	Iodides	50-62	C-C motif chemokine ligand 4	Homo sapiens	80-84
17430051-1	2007	The result of transferring a polarizable iodide anion across the H2O-CCl4 liquid/liquid interface was investigated in this study.	Iodides	41-53	C-C motif chemokine ligand 4	Homo sapiens	69-73
17408651-1	2007	BACKGROUND &amp; AIMS: The ability of thyroid cells to take up iodide, which enables (131)I radiotherapy for thyroid cancer, is due to the expression of the sodium iodide symporter at their plasma membrane.	Iodides	63-69	solute carrier family 5 member 5	Rattus norvegicus	157-180
17452787-4	2007	Here, two structures of FGE in complex with bromide and iodide were determined in order to further delineate the volume and stereochemical restraints of the oxygen-binding site for potential reaction intermediates.	Iodides	56-62	sulfatase modifying factor 1	Homo sapiens	24-27
17516290-1	2007	Carbonic anhydrase II (CA II) has an important role in thyroid hormone synthesis via regulating iodide (I-) transport across thyroidal cell membranes and the existence of autoantibodies against CA I and/or CA II have been shown in sera from patient with various autoimmune diseases such as Sjogren"s Syndrome, Systemic Lupus Erythmatosus, type 1 diabetes, primary biliary cirrhosis and ulcerative colitis.	Iodides	96-102	carbonic anhydrase 2	Homo sapiens	0-21
17516290-1	2007	Carbonic anhydrase II (CA II) has an important role in thyroid hormone synthesis via regulating iodide (I-) transport across thyroidal cell membranes and the existence of autoantibodies against CA I and/or CA II have been shown in sera from patient with various autoimmune diseases such as Sjogren"s Syndrome, Systemic Lupus Erythmatosus, type 1 diabetes, primary biliary cirrhosis and ulcerative colitis.	Iodides	96-102	carbonic anhydrase 2	Homo sapiens	23-28
17516290-1	2007	Carbonic anhydrase II (CA II) has an important role in thyroid hormone synthesis via regulating iodide (I-) transport across thyroidal cell membranes and the existence of autoantibodies against CA I and/or CA II have been shown in sera from patient with various autoimmune diseases such as Sjogren"s Syndrome, Systemic Lupus Erythmatosus, type 1 diabetes, primary biliary cirrhosis and ulcerative colitis.	Iodides	96-102	carbonic anhydrase 1	Homo sapiens	23-27
17266027-1	2007	Human sodium iodide symporter (hNIS) is a transmembrane protein that actively transports iodide ions into thyroid cells.	Iodides	13-19	solute carrier family 5 member 5	Homo sapiens	31-35
17381086-4	2007	Similar reactions employing alkyl bromides were unsuccessful and resulted in the isolation of the corresponding iodides, apparently by metathesis of the bromide oxidative addition product with KI formed during the initial InI metathesis.	Iodides	112-119	PHD finger protein 5A	Homo sapiens	222-225
17430051-7	2007	This characteristic brought the iodide ion into greater contact with CCl4, resulting in repulsive interactions with CCl4 and reducing its tendency to move to the interface.	Iodides	32-38	C-C motif chemokine ligand 4	Homo sapiens	69-73
17430051-7	2007	This characteristic brought the iodide ion into greater contact with CCl4, resulting in repulsive interactions with CCl4 and reducing its tendency to move to the interface.	Iodides	32-38	C-C motif chemokine ligand 4	Homo sapiens	116-120
17322488-1	2007	UNLABELLED: Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide in the human thyroid.	Iodides	105-111	iodotyrosine deiodinase	Homo sapiens	41-47
17158760-1	2006	This study analyzes the uptake and antiproliferative effect of two different chemical forms of iodine, iodide (I-) and molecular iodine (I2), in MCF-7 cells, which are inducible for the Na+/I- symporter (NIS) and positive for pendrin (PDS).	Iodides	103-109	solute carrier family 5 member 5	Homo sapiens	186-202
17131260-8	2007	Functional analysis of the gene product (pendrin) in Xenopus laevis oocytes revealed that pendrin acts as an iodide/chloride and chloride/formate exchanger.	Iodides	109-115	solute carrier family 26 member 4 gene 3 S homeolog	Xenopus laevis	41-48
17131260-8	2007	Functional analysis of the gene product (pendrin) in Xenopus laevis oocytes revealed that pendrin acts as an iodide/chloride and chloride/formate exchanger.	Iodides	109-115	solute carrier family 26 member 4 gene 3 S homeolog	Xenopus laevis	90-97
17214887-1	2007	BACKGROUND: The sodium/iodide symporter (NIS) is a plasma membrane glycoprotein that mediates iodide (I-) transport in the thyroid, lactating breast, salivary glands, and stomach.	Iodides	23-29	solute carrier family 5 member 5	Homo sapiens	41-44
17912014-7	2007	RESULTS: A 23- and 15.5-fold increase in iodide uptake was observed in Ad/MUC1/NIS-infected MUC1-positive Capan-2 and SW1990 cells with no significant increase observed in MUC1-negative Hela cells or in cells infected with the control virus.	Iodides	41-47	mucin 1, cell surface associated	Homo sapiens	74-78
17912014-7	2007	RESULTS: A 23- and 15.5-fold increase in iodide uptake was observed in Ad/MUC1/NIS-infected MUC1-positive Capan-2 and SW1990 cells with no significant increase observed in MUC1-negative Hela cells or in cells infected with the control virus.	Iodides	41-47	solute carrier family 5 member 5	Homo sapiens	79-82
17912014-7	2007	RESULTS: A 23- and 15.5-fold increase in iodide uptake was observed in Ad/MUC1/NIS-infected MUC1-positive Capan-2 and SW1990 cells with no significant increase observed in MUC1-negative Hela cells or in cells infected with the control virus.	Iodides	41-47	mucin 1, cell surface associated	Homo sapiens	92-96
17912014-7	2007	RESULTS: A 23- and 15.5-fold increase in iodide uptake was observed in Ad/MUC1/NIS-infected MUC1-positive Capan-2 and SW1990 cells with no significant increase observed in MUC1-negative Hela cells or in cells infected with the control virus.	Iodides	41-47	mucin 1, cell surface associated	Homo sapiens	92-96
17317846-0	2007	Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant.	Iodides	66-72	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	15-19
17317846-0	2007	Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant.	Iodides	66-72	mitogen-activated protein kinase kinase 7	Homo sapiens	20-23
17317846-0	2007	Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant.	Iodides	66-72	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	130-134
23662038-11	2006	The most promising of these was Pendrin, or Slc26a4, a solute carrier of chloride and iodide active in the kidney, thyroid, and inner ear.	Iodides	86-92	solute carrier family 26 member 4	Rattus norvegicus	32-39
16887886-7	2006	Because PKA I stimulation could increase iodide uptake in FRTL5 cells without affecting gene transcription, PKA I may mediate TSH actions at posttranscriptional levels.	Iodides	41-47	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	8-11
23662038-11	2006	The most promising of these was Pendrin, or Slc26a4, a solute carrier of chloride and iodide active in the kidney, thyroid, and inner ear.	Iodides	86-92	solute carrier family 26 member 4	Rattus norvegicus	44-51
16954431-1	2006	The sodium/iodide symporter (NIS) mediates iodide uptake in the thyroid gland and lactating breast.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
17055311-1	2006	Pendrin is a membrane transport protein which functions as the transporter of chloride, bicarbonate, formate, and iodide.	Iodides	114-120	solute carrier family 26, member 4	Mus musculus	0-7
16803457-4	2006	Quenching of intrinsic Pgp tryptophan fluorescence by acrylamide, iodide and caesium indicated that conformational changes took place upon formation of the trapped complexes.	Iodides	66-72	ATP binding cassette subfamily B member 1	Homo sapiens	23-26
16984250-3	2006	The Na(+)/I(-) symporter (NIS) localized in placental cells appears to be involved in iodide exchange.	Iodides	86-92	solute carrier family 5 member 5	Homo sapiens	4-24
16984250-3	2006	The Na(+)/I(-) symporter (NIS) localized in placental cells appears to be involved in iodide exchange.	Iodides	86-92	solute carrier family 5 member 5	Homo sapiens	26-29
17045167-1	2006	The plasma membrane glycoprotein sodium/iodide symporter (NIS) is crucial for thyroid hormone biosynthesis and mediates the iodide uptake of thyrocytes.	Iodides	40-46	solute carrier family 5 member 5	Homo sapiens	58-61
16987011-2	2006	The DUOX1 and DUOX2 mRNAs were originally cloned from thyroid tissue, and the corresponding proteins were recognized as intricate components of the thyroid hormone synthesis process, providing hydrogen peroxide essential for the organification of iodide.	Iodides	247-253	dual oxidase 1	Homo sapiens	4-9
16987011-2	2006	The DUOX1 and DUOX2 mRNAs were originally cloned from thyroid tissue, and the corresponding proteins were recognized as intricate components of the thyroid hormone synthesis process, providing hydrogen peroxide essential for the organification of iodide.	Iodides	247-253	dual oxidase 2	Homo sapiens	14-19
16987011-3	2006	The function of DUOX2 in thyroid hormonogenesis has been firmly established by linking the congenital hypothyroid phenotype "total iodide organification defect" to biallelic inactivating DUOX2 mutations.	Iodides	131-137	dual oxidase 2	Homo sapiens	16-21
16954431-1	2006	The sodium/iodide symporter (NIS) mediates iodide uptake in the thyroid gland and lactating breast.	Iodides	43-49	solute carrier family 5 member 5	Homo sapiens	29-32
21690834-7	2006	With bromide and iodide clearly different behaviour was observed, indicating specific interactions between RR-1 and these counter-ions.	Iodides	17-23	ribonucleotide reductase catalytic subunit M1	Homo sapiens	107-111
16843823-7	2006	Iodide strongly suppresses the H2O2-generated production of TPO radical adducts and protects the enzyme from loss of enzyme activity.	Iodides	0-6	thyroid peroxidase	Homo sapiens	60-63
16938132-3	2006	METHODS: To demonstrate that CFTR is also expressed in tracheal smooth muscle cells (TSMC), we used iodide efflux assay to analyse the chloride transports in organ culture of rat TSMC, immunofluorescence study to localize CFTR proteins and isometric contraction measurement on isolated tracheal rings to observe the implication of CFTR in the bronchodilation.	Iodides	100-106	CF transmembrane conductance regulator	Rattus norvegicus	29-33
16837620-1	2006	The uptake of iodide represents the first step in thyroid hormone synthesis by thyroid follicular cells and is mediated by the sodium-iodide symporter (NIS).	Iodides	14-20	solute carrier family 5 member 5 L homeolog	Xenopus laevis	127-150
16684826-12	2006	The mutant pendrin (p.R776C) retained its ability to transport iodide in vitro.	Iodides	63-69	solute carrier family 26 member 4	Homo sapiens	11-18
16791395-1	2006	BACKGROUND: Pendrin, an anion exchanger known to participate in iodide transport in the apical membrane of follicular cells of the thyroid gland, has recently been shown to exist in the apical membrane of the beta- and gamma-intercalated (beta/gamma-IC) cells of the cortical collecting duct (CCD).	Iodides	64-70	pendrin	Oryctolagus cuniculus	12-19
16800503-1	2006	Surface segregation of iodide, but not of fluoride or cesium ions, is observed by a combination of metastable impact electron spectroscopy (MIES) and ultraviolet photoelectron spectroscopy (UPS(HeI)) of amorphous solid water exposed to CsI or CsF vapor.	Iodides	23-29	colony stimulating factor 2	Homo sapiens	243-246
16719110-5	2006	However, TOX concentrations decreased substantially with increasing initial iodide concentrations.	Iodides	76-82	thymocyte selection associated high mobility group box	Homo sapiens	9-12
16839256-5	2006	When thyroid follicles were cultured in high-iodide (10(5) M) medium, TSH-induced expression of VEGF-A, VEGF-B, and PGF was decreased, accompanied by a reduction of VEGF-A release into the medium.	Iodides	45-51	vascular endothelial growth factor B	Homo sapiens	104-110
16839256-5	2006	When thyroid follicles were cultured in high-iodide (10(5) M) medium, TSH-induced expression of VEGF-A, VEGF-B, and PGF was decreased, accompanied by a reduction of VEGF-A release into the medium.	Iodides	45-51	placental growth factor	Homo sapiens	116-119
16839256-8	2006	CONCLUSIONS: We have demonstrated for the first time that iodide at high concentration decreases the expression of the angiogenic factors VEGF-A, VEGF-B, and PGF, accompanied by an increase in the expression of possible antiangiogenic factors such as PLAU.	Iodides	58-64	vascular endothelial growth factor A	Homo sapiens	138-144
16839256-8	2006	CONCLUSIONS: We have demonstrated for the first time that iodide at high concentration decreases the expression of the angiogenic factors VEGF-A, VEGF-B, and PGF, accompanied by an increase in the expression of possible antiangiogenic factors such as PLAU.	Iodides	58-64	vascular endothelial growth factor B	Homo sapiens	146-152
16839256-8	2006	CONCLUSIONS: We have demonstrated for the first time that iodide at high concentration decreases the expression of the angiogenic factors VEGF-A, VEGF-B, and PGF, accompanied by an increase in the expression of possible antiangiogenic factors such as PLAU.	Iodides	58-64	placental growth factor	Homo sapiens	158-161
16839256-8	2006	CONCLUSIONS: We have demonstrated for the first time that iodide at high concentration decreases the expression of the angiogenic factors VEGF-A, VEGF-B, and PGF, accompanied by an increase in the expression of possible antiangiogenic factors such as PLAU.	Iodides	58-64	plasminogen activator, urokinase	Homo sapiens	251-255
16839256-0	2006	Iodide inhibits vascular endothelial growth factor-A expression in cultured human thyroid follicles: a microarray search for effects of thyrotropin and iodide on angiogenesis factors.	Iodides	0-6	vascular endothelial growth factor A	Homo sapiens	16-52
16839256-5	2006	When thyroid follicles were cultured in high-iodide (10(5) M) medium, TSH-induced expression of VEGF-A, VEGF-B, and PGF was decreased, accompanied by a reduction of VEGF-A release into the medium.	Iodides	45-51	vascular endothelial growth factor A	Homo sapiens	96-102
16570991-4	2006	For the H2O-CCl4 interface, though, there was a compensation between these strong hydrogen bonds and short to moderate ranged repulsion between iodide and CCl4.	Iodides	144-150	C-C motif chemokine ligand 4	Homo sapiens	12-16
16648292-4	2006	In addition, we found that PDS gene was induced by TSH/cAMP and iodide in the presence of Tg.	Iodides	64-70	solute carrier family 26 member 4	Homo sapiens	27-30
16644756-4	2006	Functional hNIS expression in hepatoma cells was confirmed by an iodide uptake assay.	Iodides	65-71	solute carrier family 5 member 5	Homo sapiens	11-15
16644756-14	2006	CONCLUSION: A therapeutic effect of (131)I on hepatoma cells in vitro and in vivo has been demonstrated after tumor-specific iodide uptake induced by mAlb-directed hNIS gene expression.	Iodides	125-131	solute carrier family 5 member 5	Homo sapiens	164-168
16610826-1	2006	The thermal decomposition of quaternary ethylammonium chloride, bromide, and iodide has been studied using the experimental techniques of thermal gravimetry coupled to Fourier transform infrared spectroscopy (TG-FTIR) and differential scanning calorimetry (DSC) as well as the density functional theory (DFT) and MP2 quantum-chemical methods.	Iodides	77-83	tryptase pseudogene 1	Homo sapiens	313-316
16570991-0	2006	Distribution, structure, and dynamics of cesium and iodide ions at the H2O-CCl4 and H2O-vapor interfaces.	Iodides	52-58	C-C motif chemokine ligand 4	Homo sapiens	75-79
16570991-4	2006	For the H2O-CCl4 interface, though, there was a compensation between these strong hydrogen bonds and short to moderate ranged repulsion between iodide and CCl4.	Iodides	144-150	C-C motif chemokine ligand 4	Homo sapiens	155-159
16791000-2	2006	It is assumed that SLC26A4 acts as a chloride/anion exchanger responsible for the iodide organification in the thyroid gland, and conditioning of the endolymphatic fluid in the inner ear.	Iodides	82-88	solute carrier family 26 member 4	Homo sapiens	19-26
16584511-0	2006	HEX, PAX-8 and TTF-1 gene expression in human thyroid tissues: a comparative analysis with other genes involved in iodide metabolism.	Iodides	115-121	hematopoietically expressed homeobox	Homo sapiens	0-3
16584511-0	2006	HEX, PAX-8 and TTF-1 gene expression in human thyroid tissues: a comparative analysis with other genes involved in iodide metabolism.	Iodides	115-121	NK2 homeobox 1	Homo sapiens	15-20
16631088-5	2006	hNIS function was determined by iodide uptake assay and MnSOD, and p53 protein levels were assessed by Western blots.	Iodides	32-38	solute carrier family 5 member 5	Homo sapiens	0-4
16306076-0	2006	The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland.	Iodides	55-61	chloride channel, voltage-sensitive 5	Mus musculus	34-39
16514173-3	2006	Active (driven by Na(+)/K(+)-ATPase) iodide transport into thyroid follicular cells is mediated by the sodium-iodide symporter (NIS), which is also abundantly expressed in gastric mucosa.	Iodides	37-43	solute carrier family 5 member 5	Rattus norvegicus	103-126
16316988-1	2006	The enzyme responsible for iodide salvage in the thyroid, iodotyrosine deiodinase, was solubilized from porcine thyroid microsomes by limited proteolysis with trypsin.	Iodides	27-33	iodotyrosine deiodinase	Homo sapiens	58-81
16322276-1	2006	BACKGROUND: Iodide organification defects are associated with mutations in the dual oxidase 2 (DUOX2) gene and are characterized by a positive perchlorate discharge test.	Iodides	12-18	dual oxidase 2	Homo sapiens	79-93
16322276-1	2006	BACKGROUND: Iodide organification defects are associated with mutations in the dual oxidase 2 (DUOX2) gene and are characterized by a positive perchlorate discharge test.	Iodides	12-18	dual oxidase 2	Homo sapiens	95-100
16052231-3	2006	Pre-incubation of the NIS/TPO-modified NSCLC cells in iodide followed by ionizing radiation generates bystander tumoricidal effects and potently enhances tumor cell killing.	Iodides	54-60	thyroid peroxidase	Homo sapiens	26-29
16052231-4	2006	This iodide-induced bystander effect is associated with enhanced gap junction intercellular communication (GJIC) activity and increased connexin-43 (Cx43) expression.	Iodides	5-11	gap junction protein alpha 1	Homo sapiens	136-147
16052231-4	2006	This iodide-induced bystander effect is associated with enhanced gap junction intercellular communication (GJIC) activity and increased connexin-43 (Cx43) expression.	Iodides	5-11	gap junction protein alpha 1	Homo sapiens	149-153
16914891-2	2006	It is generally assumed that SLC26A4 acts as a chloride/anion exchanger, which in the thyroid gland transports iodide, and in the inner ear contributes to the conditioning of the endolymphatic fluid.	Iodides	111-117	solute carrier family 26 member 4	Homo sapiens	29-36
16914891-4	2006	The validation of the method was done by functionally characterizing the chloride/iodide transport of SLC26A4, and a mutant, i.e. SLC26A4(S28R), which we previously described in a patient with sensorineural hearing loss, hypothyroidism and goiter.	Iodides	82-88	solute carrier family 26 member 4	Homo sapiens	102-109
16914891-5	2006	Using the fluorometric method we describe here we can continuously monitor and quantify the iodide or chloride amounts transported by the cells, and we found that the transport capability of the SLC26A4(S28R) mutant protein is markedly reduced if compared to wild-type SLC26A4.	Iodides	92-98	solute carrier family 26 member 4	Homo sapiens	195-202
16306076-8	2006	Enhanced 125I- efflux upon perchlorate and presence of 125I-Tg as autoradiographic rings at follicle periphery demonstrated delayed iodide organification.	Iodides	132-138	thyroglobulin	Mus musculus	60-62
16306076-10	2006	Expression of pendrin, an I-/Cl- exchanger involved in apical iodide efflux, was selectively decreased by 60% in KO mice at mRNA and protein levels.	Iodides	62-68	solute carrier family 26, member 4	Mus musculus	14-21
16306076-12	2006	Instead, the goiter associated with ClC-5 KO results from impaired rate of apical iodide efflux by down-regulation of pendrin expression.	Iodides	82-88	chloride channel, voltage-sensitive 5	Mus musculus	36-41
16190863-9	2006	The tryptophan residues in CYP2D6 appeared to be less accessible for the external quenchers iodide and acrylamide in presence of MAMC, indicating a tightening of the enzyme structure upon substrate binding.	Iodides	92-98	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	27-33
16791000-6	2006	Furthermore, we show that the SLC26A4 induced chloride uptake in HEK293-Phoenix cells competes with iodide, and, in addition, that the chloride uptake can be blocked by NPPB and niflumic acid, whereas DIDS is ineffective.	Iodides	100-106	solute carrier family 26 member 4	Homo sapiens	30-37
16853919-5	2005	The stability of N719 dye during solar cell operation was discussed based on this number, and on values of the electron-transfer rate between [Ru(III)L2(NCS)2] and iodide ion that are available in the literature.	Iodides	164-170	cytosolic thiouridylase subunit 2	Homo sapiens	153-158
16924389-4	2006	Expression of the SLC26A4 gene may be responsible for iodide transport in the thyroid as well as for formation and function of the inner ear.	Iodides	54-60	solute carrier family 26 member 4	Homo sapiens	18-25
16604470-2	2005	Here, we studied the contribution of the conserved residues G551 and G1349 to the pharmacological modulation of CFTR chloride channels by phloxine B using iodide efflux and whole-cell patch clamp experiments performed on the following green fluorescent protein (GFP)-tagged CFTR: wild-type, delF508, G551D, G1349D, and G551D/G1349D double mutant.	Iodides	155-161	CF transmembrane conductance regulator	Homo sapiens	112-116
16121204-3	2006	Radioiodide is routinely and effectively used for the treatment of benign and malignant thyroid disease as a result of native thyroidal expression of NIS, which mediates iodide uptake.	Iodides	5-11	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	150-153
16121204-4	2006	In vitro gene transfer studies in ovarian cancer cells revealed a 12- and five-fold increase in iodide uptake when transduced with Ad/CMV/NIS or Ad/MUC1/NIS, respectively.	Iodides	96-102	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	138-141
16121204-4	2006	In vitro gene transfer studies in ovarian cancer cells revealed a 12- and five-fold increase in iodide uptake when transduced with Ad/CMV/NIS or Ad/MUC1/NIS, respectively.	Iodides	96-102	mucin 1, transmembrane	Mus musculus	148-152
16121204-4	2006	In vitro gene transfer studies in ovarian cancer cells revealed a 12- and five-fold increase in iodide uptake when transduced with Ad/CMV/NIS or Ad/MUC1/NIS, respectively.	Iodides	96-102	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	153-156
16253762-1	2005	The sodium/iodide symporter (NIS) actively transports iodide into thyrocytes.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
16253762-7	2005	By transient transfection and I-125 uptake assay, we found that the wild type NIS-expressing HepG2 cells accumulated six times more iodide than mutant and mock HepG2 cells.	Iodides	132-138	solute carrier family 5 member 5	Homo sapiens	78-81
16274882-5	2005	The chlorination activity of myeloperoxidase was measured by trapping hypochlorous acid with taurine and subsequently using iodide to promote the oxidation reactions of the accumulated taurine chloramine.	Iodides	124-130	myeloperoxidase	Homo sapiens	29-44
16092068-1	2005	Sodium-iodide-symporter (NIS), an integral plasma membrane glycoprotein, mediates the sodium-dependent active uptake of iodide (I(-)) into the thyroid gland, which is a fundamental step in thyroid hormone synthesis.	Iodides	7-13	solute carrier family 5 member 5	Rattus norvegicus	25-28
16257484-3	2005	Since earlier morphological studies showed that some phthalates induced thyroid hyperactivity, we thought it important to investigate possible effects of six major phthalates on the transcriptional activity of sodium/iodide symporter (NIS).	Iodides	217-223	solute carrier family 5 member 5	Homo sapiens	235-238
16105966-0	2005	Cell surface targeting accounts for the difference in iodide uptake activity between human Na+/I- symporter and rat Na+/I- symporter.	Iodides	54-60	solute carrier family 5 member 5	Homo sapiens	91-107
16105966-0	2005	Cell surface targeting accounts for the difference in iodide uptake activity between human Na+/I- symporter and rat Na+/I- symporter.	Iodides	54-60	solute carrier family 5 member 5	Rattus norvegicus	116-132
16212380-3	2005	Crystallographic results show binding of the acyclic quasiplanar water tetramer [H4L(H2O)4](I)4.2.57H2O (1) in a tetraprotonated cryptand L having an iodide counteranion, where two water molecules reside inside the two tren-based cavity, bridged by a third water molecule, and a fourth external water molecule is hydrogen bonded to the bridged water molecule.	Iodides	150-156	H4 clustered histone 7	Homo sapiens	81-84
16081479-3	2005	Using an iodide efflux assay we demonstrated stimulation of CFTR by VIP, isoproterenol, cAMP agonists and other pharmacological activators in cultured VSMC from Cftr(+/+).	Iodides	9-15	cystic fibrosis transmembrane conductance regulator	Mus musculus	60-64
16081479-3	2005	Using an iodide efflux assay we demonstrated stimulation of CFTR by VIP, isoproterenol, cAMP agonists and other pharmacological activators in cultured VSMC from Cftr(+/+).	Iodides	9-15	vasoactive intestinal polypeptide	Mus musculus	68-71
16081479-3	2005	Using an iodide efflux assay we demonstrated stimulation of CFTR by VIP, isoproterenol, cAMP agonists and other pharmacological activators in cultured VSMC from Cftr(+/+).	Iodides	9-15	cystic fibrosis transmembrane conductance regulator	Mus musculus	161-165
16203867-4	2005	LPA inhibited CFTR-dependent iodide efflux through LPA2-mediated Gi pathway, and LPA inhibited CFTR-mediated short-circuit currents in a compartmentalized fashion.	Iodides	29-35	cystic fibrosis transmembrane conductance regulator	Mus musculus	14-18
16196493-6	2005	Incubation of BHK cells stably expressing human DeltaF508 CFTR with 1-10 microM CF(cor)-325 resulted in maturation and delivery of a functional molecule to the cell surface as determined by the iodide efflux assay.	Iodides	194-200	CF transmembrane conductance regulator	Homo sapiens	58-62
16049678-10	2005	It was also completely inhibited by iodide, an H(2)O(2)-scavenger, indicating a role for peroxidase rather than oxidase.	Iodides	36-42	peroxidase 1	Zea mays	89-99
16260428-1	2005	OBJECTIVE: The SLC26A4 protein (pendrin) seems to be involved in the exchange of chloride with other anions, therefore being responsible for iodide organification in the thyroid gland and the conditioning of the endolymphatic fluid in the inner ear.	Iodides	141-147	solute carrier family 26 member 4	Homo sapiens	15-22
16260428-1	2005	OBJECTIVE: The SLC26A4 protein (pendrin) seems to be involved in the exchange of chloride with other anions, therefore being responsible for iodide organification in the thyroid gland and the conditioning of the endolymphatic fluid in the inner ear.	Iodides	141-147	solute carrier family 26 member 4	Homo sapiens	32-39
16127463-3	2005	To identify small-molecule correctors of defective cellular processing, we assayed iodide flux in DeltaF508-CFTR-transfected epithelial cells using a fluorescent halide indicator.	Iodides	83-89	CF transmembrane conductance regulator	Homo sapiens	108-112
16097833-6	2005	Salt metathesis of UI3(thf)4 with potassium triflate in acetonitrile resulted in the complete substitution of the iodide counterions by triflate producing the acetonitrile solvate [U(OTf)3(MeCN)3]n (3).	Iodides	114-120	POU class 5 homeobox 1	Homo sapiens	181-188
16187919-1	2005	Thyroid peroxidase (TPO) deficiency is frequently involved in total iodide organification defects (TIOD).	Iodides	68-74	thyroid peroxidase	Homo sapiens	0-18
16187919-1	2005	Thyroid peroxidase (TPO) deficiency is frequently involved in total iodide organification defects (TIOD).	Iodides	68-74	thyroid peroxidase	Homo sapiens	20-23
16029487-1	2005	BACKGROUND: Recovery of iodide uptake in thyroid cancer cells by means of obtaining the functional expression of the sodium/iodide symporter (NIS) represents an innovative strategy for the treatment of poorly differentiated thyroid cancer.	Iodides	24-30	solute carrier family 5 member 5	Homo sapiens	142-145
15941870-4	2005	Functional hNIS expression was confirmed by iodide accumulation assays, Northern and Western blot analysis, immunostaining, and in vitro clonogenic assay.	Iodides	44-50	solute carrier family 5 member 5	Homo sapiens	11-15
15941870-5	2005	RESULTS: hNIS-transfected TT cells showed perchlorate-sensitive iodide uptake, accumulating 125-I about 12-fold in vitro with organification of 4% of accumulated iodide resulting in a significant decrease in iodide efflux.	Iodides	64-70	solute carrier family 5 member 5	Homo sapiens	9-13
15941870-5	2005	RESULTS: hNIS-transfected TT cells showed perchlorate-sensitive iodide uptake, accumulating 125-I about 12-fold in vitro with organification of 4% of accumulated iodide resulting in a significant decrease in iodide efflux.	Iodides	162-168	solute carrier family 5 member 5	Homo sapiens	9-13
15941870-9	2005	CONCLUSIONS: A therapeutic effect of 131-I has been demonstrated in MTC cells after induction of tissue-specific iodide uptake activity by calcitonin promoter-directed hNIS expression.	Iodides	113-119	solute carrier family 5 member 5	Homo sapiens	168-172
15901792-6	2005	The iodide secretion from PDE3 or PDE4 inhibition was characterized at first by a prolonged efflux duration, followed by progressively elevated peak efflux rates at higher inhibitor concentrations.	Iodides	4-10	phosphodiesterase 4D	Homo sapiens	34-38
15901792-8	2005	2-(4-Fluorophenoxy)-N-[(1S)-1-(4-methoxyphenyl)ethyl]nicotinamide, a stereoselective PDE4D inhibitor, augmented iodide efflux more efficiently than its less potent (R)-isomer.	Iodides	112-118	phosphodiesterase 4D	Homo sapiens	85-90
16029487-1	2005	BACKGROUND: Recovery of iodide uptake in thyroid cancer cells by means of obtaining the functional expression of the sodium/iodide symporter (NIS) represents an innovative strategy for the treatment of poorly differentiated thyroid cancer.	Iodides	124-130	solute carrier family 5 member 5	Homo sapiens	142-145
16029487-11	2005	CONCLUSION: These finding demonstrate that induction of Pax8 expression may determine a re-differentiation of thyroid cancer cells, including a partial recovery of iodide uptake, fundamental requisite for a radioiodine-based therapeutic approach for thyroid tumours.	Iodides	164-170	paired box 8	Homo sapiens	56-60
15942636-1	2005	The Pendred syndrome gene (PDS) encodes a transmembrane protein, pendrin, which is expressed in follicular thyroid cells and participates in the apical iodide transport.	Iodides	152-158	solute carrier family 26 member 4	Homo sapiens	65-72
15741084-5	2005	Though TO-PRO-3 iodide staining experiments using confocal microscopy, we observed the immobilized DNA on the surface of the nanoneedle, which was retained after 10 times insertions to and evacuations from a living cell.	Iodides	16-22	pyrroline-5-carboxylate reductase 1	Homo sapiens	10-15
15981995-4	2005	In this study, we have performed a structural characterization of the binding of two halides, iodide and chloride, to TTR.	Iodides	94-100	transthyretin	Homo sapiens	118-121
15981995-7	2005	To elucidate binding sites of the halides, we took advantage of the anomalous scattering of iodide and used the single-wavelength anomalous dispersion (SAD) method to solve the iodide-bound TTR structure at 1.8 A resolution.	Iodides	177-183	transthyretin	Homo sapiens	190-193
15901171-2	2005	The cross-coupling of bromomagnesium diarylamides, generated in situ from diarylamines, with aryl bromides or iodides can be effected with a simple NiCl2(PPh3)2-PPh3 catalyst system under relatively mild conditions.	Iodides	110-117	caveolin 1	Homo sapiens	154-158
15901171-2	2005	The cross-coupling of bromomagnesium diarylamides, generated in situ from diarylamines, with aryl bromides or iodides can be effected with a simple NiCl2(PPh3)2-PPh3 catalyst system under relatively mild conditions.	Iodides	110-117	caveolin 1	Homo sapiens	161-165
16053392-11	2005	In functional studies, these mutants lose the ability of pendrin to mediate iodide efflux.	Iodides	76-82	solute carrier family 26 member 4	Homo sapiens	57-64
15781380-1	2005	The existence of the natriuric/iodide symporter (NIS) represents a new view to understand the thyroid metabolism of iodide.	Iodides	31-37	solute carrier family 5 member 5	Homo sapiens	49-52
15780262-4	2005	Iodide concentration has a significant influence on the relative population of I9(3-), I11(3-), and I13(3-), as well as I3- and I5-, which lead to changes in both the UV/Vis absorption maxima shifts and changes in the Raman spectra.	Iodides	0-6	brain protein I3	Homo sapiens	120-130
15623812-6	2005	A low but significant increase in iodide uptake was produced by treatment with activators of the adenylyl cyclase (cAMP) or protein kinase C pathways.	Iodides	34-40	cathelicidin antimicrobial peptide	Homo sapiens	115-120
15623812-7	2005	Our study demonstrates that: 1) MCF-7 breast cancer cells are capable of active iodide transport that can be stimulated by insulin, IGF-I, IGF-II, or prolactin; 2) both NIS transcript and protein are expressed in these cells, and this expression is also hormonally stimulated; and 3) MCF-7 iodide transport and NIS expression may be influenced by the activation of cAMP or protein kinase C-dependent signaling.	Iodides	80-86	insulin	Homo sapiens	123-130
15623812-7	2005	Our study demonstrates that: 1) MCF-7 breast cancer cells are capable of active iodide transport that can be stimulated by insulin, IGF-I, IGF-II, or prolactin; 2) both NIS transcript and protein are expressed in these cells, and this expression is also hormonally stimulated; and 3) MCF-7 iodide transport and NIS expression may be influenced by the activation of cAMP or protein kinase C-dependent signaling.	Iodides	80-86	insulin like growth factor 1	Homo sapiens	132-137
15623812-7	2005	Our study demonstrates that: 1) MCF-7 breast cancer cells are capable of active iodide transport that can be stimulated by insulin, IGF-I, IGF-II, or prolactin; 2) both NIS transcript and protein are expressed in these cells, and this expression is also hormonally stimulated; and 3) MCF-7 iodide transport and NIS expression may be influenced by the activation of cAMP or protein kinase C-dependent signaling.	Iodides	80-86	insulin like growth factor 2	Homo sapiens	139-145
15781380-3	2005	Clinical perspectives of NIS activity modulation would ameliorate the diagnosis and the treatment of thyroid diseases by using radioisotopes transported by the NIS (131 iodide, 99m technetium, 188 rhenium).	Iodides	169-175	solute carrier family 5 member 5	Homo sapiens	25-28
15781380-3	2005	Clinical perspectives of NIS activity modulation would ameliorate the diagnosis and the treatment of thyroid diseases by using radioisotopes transported by the NIS (131 iodide, 99m technetium, 188 rhenium).	Iodides	169-175	solute carrier family 5 member 5	Homo sapiens	160-163
15720385-4	2005	We applied the iodide and acrylamide fluorescence quenching method in order to study how different DNA sequences and cAMP binding induce the conformational changes in the CRP molecule.	Iodides	15-21	catabolite gene activator protein	Escherichia coli	171-174
15746050-1	2005	PURPOSE: Expression of the sodium iodide symporter (NIS) in the thyroid gland provides for effective imaging and treatment of thyroid cancer using radiolabeled iodide.	Iodides	34-40	solute carrier family 5 member 5	Homo sapiens	52-55
15704930-1	2005	The reaction of iodides 1 with delta-chloropropylamines 5 in MeCN assisted with K2CO3 undergoes a sequential S(N)2/Michael addition/SN2/SN2 reaction process to give polysubstituted indolizidines and quinolizidines.	Iodides	16-23	solute carrier family 38 member 5	Homo sapiens	132-135
15704930-1	2005	The reaction of iodides 1 with delta-chloropropylamines 5 in MeCN assisted with K2CO3 undergoes a sequential S(N)2/Michael addition/SN2/SN2 reaction process to give polysubstituted indolizidines and quinolizidines.	Iodides	16-23	solute carrier family 38 member 5	Homo sapiens	136-139
15746050-8	2005	RESULTS: A 58-fold increase in iodide uptake was observed in infected MUC1-positive T47D cells with no significant increase observed in MUC1-negative MDA-MB-231 cells or in cells infected with the control virus.	Iodides	31-37	mucin 1, cell surface associated	Homo sapiens	70-74
15745925-1	2005	OBJECTIVE: Defects in the human thyroid peroxidase (TPO) gene are reported to be one of the causes of congenital hypothyroidism (CH) due to a total iodide organification defect.	Iodides	148-154	thyroid peroxidase	Homo sapiens	32-50
15745925-1	2005	OBJECTIVE: Defects in the human thyroid peroxidase (TPO) gene are reported to be one of the causes of congenital hypothyroidism (CH) due to a total iodide organification defect.	Iodides	148-154	thyroid peroxidase	Homo sapiens	52-55
15695791-5	2005	The iodide uptake of F3-NIS III cells was initially higher by up to 12.9-fold than that of nontransfected HB1.F3 cells.	Iodides	4-10	solute carrier family 5 member 5	Homo sapiens	24-27
15510175-11	2005	In conclusion, a therapeutic effect of (131)I has been demonstrated in colon carcinoma cells following induction of tumor-specific iodide uptake activity by CEA promoter-directed NIS expression in vitro.	Iodides	131-137	CEA cell adhesion molecule 3	Homo sapiens	157-160
15852865-0	2005	[The research on the quenching of fluorescence spectra of TOP I by iodine anion].	Iodides	67-79	DNA topoisomerase 1-like	Nicotiana tabacum	58-63
15691889-3	2005	We aimed to investigate whether iodide could modulate the biological effects of activating TSHR mutations.	Iodides	32-38	thyroid stimulating hormone receptor	Rattus norvegicus	91-95
15695791-8	2005	RESULTS: As hNIS transgene was gradually silenced in F3-NIS III cells, after the eighth passage its iodide uptake was 1.9-fold higher than that of nontransfected HB1.F3 cells.	Iodides	100-106	solute carrier family 5 member 5	Homo sapiens	12-16
15691889-13	2005	In conclusion, our studies indicate that the biological effects of activating TSHR mutations vary with the ambient iodide supply and could be masked in regions of high iodine intake.	Iodides	115-121	thyroid stimulating hormone receptor	Rattus norvegicus	78-82
15695791-8	2005	RESULTS: As hNIS transgene was gradually silenced in F3-NIS III cells, after the eighth passage its iodide uptake was 1.9-fold higher than that of nontransfected HB1.F3 cells.	Iodides	100-106	solute carrier family 5 member 5	Homo sapiens	13-16
15695791-9	2005	5-azacytidine treatment (up to 40 micromol/L) for 24 h in F3-NIS III cells increased iodide uptake and hNIS messenger RNA (mRNA) 1.8- and 1.9-fold versus nontreated F3-NIS cells, respectively.	Iodides	85-91	solute carrier family 5 member 5	Homo sapiens	61-64
15695791-10	2005	Moreover, after TSA treatment (up to 62.5 nmol/L) for 24 h, iodide uptake and hNIS mRNA in F3-NIS III cells increased 36- and 1.9-fold versus nontreated F3-NIS III cells, respectively.	Iodides	60-66	solute carrier family 5 member 5	Homo sapiens	94-97
15605154-1	2005	Reactions of the halides X- (X- = chloride, bromide or iodide) with the substituted cluster Rh6(CO)15(PPh3) in oxygen-free chloroform lead to [Rh5(CO)14(PPh3)]-, Rh(CO)2(PPh3)2X and [Rh(CO)2X2]- in the molar ratios 2:1: approximately 13.	Iodides	55-61	protein phosphatase 4 catalytic subunit	Homo sapiens	102-106
15520004-9	2005	Absolute values for lifetime and anisotropy were lower for the CCK-8 probe bound to the type B receptor than for this probe bound to the type A receptor, and Alexa fluorescence was more easily quenched by iodide at the type B receptor.	Iodides	205-211	cholecystokinin	Homo sapiens	63-66
15605154-1	2005	Reactions of the halides X- (X- = chloride, bromide or iodide) with the substituted cluster Rh6(CO)15(PPh3) in oxygen-free chloroform lead to [Rh5(CO)14(PPh3)]-, Rh(CO)2(PPh3)2X and [Rh(CO)2X2]- in the molar ratios 2:1: approximately 13.	Iodides	55-61	protein phosphatase 4 catalytic subunit	Homo sapiens	153-157
15605154-1	2005	Reactions of the halides X- (X- = chloride, bromide or iodide) with the substituted cluster Rh6(CO)15(PPh3) in oxygen-free chloroform lead to [Rh5(CO)14(PPh3)]-, Rh(CO)2(PPh3)2X and [Rh(CO)2X2]- in the molar ratios 2:1: approximately 13.	Iodides	55-61	protein phosphatase 4 catalytic subunit	Homo sapiens	153-157
15585488-1	2004	UNLABELLED: (131)I-Iodide is the treatment of choice in most cases of hyperthyroidism, with a standard 7,000-cGy (rad) thyroid absorbed dose generally resulting in an incidental blood absorbed dose of less than 10 cGy (rad).	Iodides	17-25	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	114-117
15522214-4	2004	Iodide efflux is slower in ARH-77 and K-562 cells expressing NIS compared to a thyroid cell line.	Iodides	0-6	low density lipoprotein receptor adaptor protein 1	Homo sapiens	27-30
15579773-0	2004	Forskolin, 8-Br-3",5"-cyclic adenosine 5"-monophosphate, and catalytic protein kinase A expression in the nucleus increase radioiodide uptake and sodium/iodide symporter protein levels in RET/PTC1-expressing cells.	Iodides	128-134	ret proto-oncogene	Rattus norvegicus	188-191
15579773-1	2004	RET/PTC1, a thyroid-specific oncogene, has been reported to down-regulate sodium/iodide symporter (NIS) expression and function in vitro and in vivo.	Iodides	81-87	ret proto-oncogene	Rattus norvegicus	0-3
15459116-7	2005	In contrast, TSHR antibodies, measured by TSH-binding inhibition, thyroid-stimulating activity, and TSH-blocking activity, were induced in the majority of animals immunized with TSHR (but not control) adenovirus and were unaffected by dietary iodide.	Iodides	243-249	thyroid stimulating hormone receptor	Mus musculus	13-17
15459116-7	2005	In contrast, TSHR antibodies, measured by TSH-binding inhibition, thyroid-stimulating activity, and TSH-blocking activity, were induced in the majority of animals immunized with TSHR (but not control) adenovirus and were unaffected by dietary iodide.	Iodides	243-249	thyroid stimulating hormone receptor	Mus musculus	178-182
15585488-1	2004	UNLABELLED: (131)I-Iodide is the treatment of choice in most cases of hyperthyroidism, with a standard 7,000-cGy (rad) thyroid absorbed dose generally resulting in an incidental blood absorbed dose of less than 10 cGy (rad).	Iodides	17-25	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	219-222
15454240-3	2004	The best mCA XIII inhibitors were cyanate, thiocyanate, cyanide and sulfamide, with K(I)-s in the range of 0.25microM-0.74 mM, whereas fluoride, iodide, azide, carbonate and hydrogen sulfide were less effective (K(I)-s in the range of 3.0-5.5mM).	Iodides	145-151	carbonic anhydrase 13	Mus musculus	9-17
15271884-4	2004	Although TTF-1 gene transfer faintly induced iodide uptake, the induction of sodium/iodide symporter (NIS) mRNA was not observed in AdTTF-1-infected cells.	Iodides	45-51	NK2 homeobox 1	Homo sapiens	9-14
15302866-7	2004	Instead, 17-AAG increases radioiodide accumulation by decreasing iodide efflux.	Iodides	31-37	N-methylpurine DNA glycosylase	Homo sapiens	12-15
15671766-3	2004	Iodide uptake by ARO-N was 109 times higher than by ARO, and 99mTc and 188Re uptake by ARO-N were 21 and 47 times higher than by ARO, respectively.	Iodides	0-6	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	17-20
15340050-8	2004	Remarkably, in MCF-7 cells, Nkx-2.5 overexpression alone was sufficient to induce NIS and iodide uptake.	Iodides	90-96	NK2 homeobox 5	Homo sapiens	28-35
15289438-0	2004	Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site.	Iodides	93-99	iodotyrosine deiodinase	Homo sapiens	0-27
15289438-0	2004	Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site.	Iodides	93-99	iodotyrosine deiodinase	Homo sapiens	29-35
15648551-2	2004	Na+/I- symporter (NIS) is highly expressed in BC cells, and previous studies demonstrated that iodine content in BC is lower than in remote normal breast tissue, suggesting a disorder of iodide uptake in BC.	Iodides	187-193	solute carrier family 5 member 5	Homo sapiens	0-16
15221289-1	2004	PURPOSE: We evaluated the feasibility of non-invasive imaging of recombinant adenovirus-mediated human sodium-iodide symporter (hNIS) gene expression by (99m)TcO(4)(-) scintigraphy in skeletal muscle of rats.	Iodides	110-116	solute carrier family 5 member 5	Homo sapiens	128-132
15347726-11	2004	Iodide efflux from SK-Hep1-NIS was relatively slow, with only 10% released during the initial 5 min, and 60% remained at 25 min.	Iodides	0-6	DNL-type zinc finger	Homo sapiens	22-26
15573527-9	2004	Extra iodide in the incubation media reduced TPO inhibition induced by BS but could not cancel it.	Iodides	6-12	thyroid peroxidase	Rattus norvegicus	45-48
15215159-1	2004	The uptake of iodide by epithelial thyroid cells requires the expression of a specific transporter, the Na(+)/I(-) symporter, NIS.	Iodides	14-20	solute carrier family 5 member 5	Homo sapiens	104-124
15215159-1	2004	The uptake of iodide by epithelial thyroid cells requires the expression of a specific transporter, the Na(+)/I(-) symporter, NIS.	Iodides	14-20	solute carrier family 5 member 5	Homo sapiens	126-129
15020588-5	2004	Using the iodide efflux method, a combination of agonists and pharmacological agents was used to dissect the function of CFTR.	Iodides	10-16	CF transmembrane conductance regulator	Rattus norvegicus	121-125
14976143-2	2004	Upon iodide uptake, thyroperoxidase catalyzes iodination of tyrosine residues in thyroglobulin, retaining iodide within thyroid follicles.	Iodides	5-11	thyroid peroxidase	Homo sapiens	20-35
14976143-2	2004	Upon iodide uptake, thyroperoxidase catalyzes iodination of tyrosine residues in thyroglobulin, retaining iodide within thyroid follicles.	Iodides	5-11	thyroglobulin	Homo sapiens	81-94
14976143-2	2004	Upon iodide uptake, thyroperoxidase catalyzes iodination of tyrosine residues in thyroglobulin, retaining iodide within thyroid follicles.	Iodides	106-112	thyroid peroxidase	Homo sapiens	20-35
14976143-2	2004	Upon iodide uptake, thyroperoxidase catalyzes iodination of tyrosine residues in thyroglobulin, retaining iodide within thyroid follicles.	Iodides	106-112	thyroglobulin	Homo sapiens	81-94
15240514-0	2004	The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid.	Iodides	30-36	solute carrier family 5 member 5	Homo sapiens	4-20
15240514-1	2004	PURPOSE: The Na(+)/I(-) symporter (NIS) is a key plasma membrane protein that mediates active iodide (I(-)) transport in the thyroid, lactating breast, and other tissues.	Iodides	94-100	solute carrier family 5 member 5	Homo sapiens	13-33
15218979-6	2004	Thyroid peroxidase activity (TPO) of human thyroid was assayed from microsomal fraction following I3- from iodide.	Iodides	107-113	thyroid peroxidase	Homo sapiens	0-18
15218979-6	2004	Thyroid peroxidase activity (TPO) of human thyroid was assayed from microsomal fraction following I3- from iodide.	Iodides	107-113	thyroid peroxidase	Homo sapiens	29-32
15218979-12	2004	Excess iodide was found relatively effective for raw extract but less effective for boiled and cooked extracts in reversing anti-TPO activity.	Iodides	7-13	thyroid peroxidase	Homo sapiens	129-132
15218979-15	2004	Excess iodide reversed the anti-TPO activity to same extent but could not neutralise it.	Iodides	7-13	thyroid peroxidase	Homo sapiens	32-35
14715652-1	2004	Evidence for pendrin-mediated apical iodide efflux.	Iodides	37-43	solute carrier family 26 member 4	Canis lupus familiaris	13-20
15136633-2	2004	This study evaluates the iodide kinetics and dosimetry of iodide in hNIS-expressing thyroid carcinoma cells under optimized conditions.	Iodides	25-31	solute carrier family 5 member 5	Homo sapiens	68-72
15136633-2	2004	This study evaluates the iodide kinetics and dosimetry of iodide in hNIS-expressing thyroid carcinoma cells under optimized conditions.	Iodides	58-64	solute carrier family 5 member 5	Homo sapiens	68-72
15136633-6	2004	RESULTS: hNIS-expressing cell lines accumulated up to 49 times more iodide than did noninfected cells, with a maximal iodide uptake after 30 min of incubation.	Iodides	68-74	solute carrier family 5 member 5	Homo sapiens	9-13
15136633-6	2004	RESULTS: hNIS-expressing cell lines accumulated up to 49 times more iodide than did noninfected cells, with a maximal iodide uptake after 30 min of incubation.	Iodides	118-124	solute carrier family 5 member 5	Homo sapiens	9-13
15039462-6	2004	Iodide efflux and whole-cell patch-clamp experiments on these cells indicate a strong inhibition of CFTR chloride current by syntaxin 8 overexpression.	Iodides	0-6	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	100-104
15039462-6	2004	Iodide efflux and whole-cell patch-clamp experiments on these cells indicate a strong inhibition of CFTR chloride current by syntaxin 8 overexpression.	Iodides	0-6	syntaxin-8	Cricetulus griseus	125-135
14715652-6	2004	The iodide transport properties of pendrin were determined in polarized Madin-Darby canine kidney cells expressing the sodium iodide symporter (NIS), pendrin, or NIS and pendrin using a bicameral system-permitting measurement of iodide content in the basal, intracellular, and apical compartments.	Iodides	4-10	solute carrier family 26 member 4	Canis lupus familiaris	35-42
14715652-10	2004	In cells expressing NIS and pendrin, pendrin mediates transport of iodide into the apical chamber.	Iodides	67-73	solute carrier family 26 member 4	Canis lupus familiaris	28-35
14715652-10	2004	In cells expressing NIS and pendrin, pendrin mediates transport of iodide into the apical chamber.	Iodides	67-73	solute carrier family 26 member 4	Canis lupus familiaris	37-44
14715652-11	2004	Wild type pendrin also mediates iodide efflux in transiently transfected cells.	Iodides	32-38	solute carrier family 26 member 4	Canis lupus familiaris	10-17
15136633-8	2004	In mice, the hNIS-expressing tumors accumulated up to 23 and 19.5 times more iodide than did the wild-type tumors in lithium-treated and control animals, respectively.	Iodides	77-83	solute carrier family 5 member 5	Homo sapiens	13-17
15136633-11	2004	CONCLUSION: Transduction of the hNIS gene in rat thyroid carcinoma cells induces iodide transport, which is associated with rapid efflux.	Iodides	81-87	solute carrier family 5 member 5	Homo sapiens	32-36
14715652-4	2004	Functionally, pendrin is a transporter of chloride and iodide in Xenopus oocytes and heterologous mammalian cells and a chloride/base exchanger in beta-intercalated cells of the renal cortical collecting duct.	Iodides	55-61	solute carrier family 26 member 4 gene 3 S homeolog	Xenopus laevis	14-21
14715652-12	2004	In contrast, both pendrin mutants lose the ability to promote iodide efflux.	Iodides	62-68	solute carrier family 26 member 4	Canis lupus familiaris	18-25
14715652-13	2004	These results provide evidence that pendrin mediates apical iodide efflux from polarized mammalian cells loaded with iodide.	Iodides	60-66	solute carrier family 26 member 4	Homo sapiens	36-43
14715652-13	2004	These results provide evidence that pendrin mediates apical iodide efflux from polarized mammalian cells loaded with iodide.	Iodides	117-123	solute carrier family 26 member 4	Homo sapiens	36-43
14715652-5	2004	The partially impaired thyroidal iodide organification in Pendred"s syndrome suggests a possible role of pendrin in iodide transport at the apical membrane of thyroid follicular cells, but experimental evidence for this concept is lacking.	Iodides	116-122	solute carrier family 26 member 4	Canis lupus familiaris	105-112
14715652-14	2004	Consistent with the partial organification defect observed in patients with Pendred"s syndrome, naturally occurring mutations of pendrin lead to impaired transport of iodide.	Iodides	167-173	solute carrier family 26 member 4	Homo sapiens	129-136
14734652-0	2004	The Q267E mutation in the sodium/iodide symporter (NIS) causes congenital iodide transport defect (ITD) by decreasing the NIS turnover number.	Iodides	33-39	solute carrier family 5 member 5	Homo sapiens	51-54
14985092-3	2004	The fluorescence quenching efficiencies of iodide and acrylamide are substantially reduced, indicating a shielding of phenylalanine residue of bradykinin from aqueous environment.	Iodides	43-49	kininogen 1	Homo sapiens	143-153
14980826-6	2004	The iodide ions stabilized the salt structure by forming hydrogen bonds with the N-2 and O-6 atoms of the polymer chains together with an electrostatic interaction between N-2 and the iodide ions.	Iodides	4-10	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	89-92
14630715-0	2004	Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1.	Iodides	43-49	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	77-91
15001644-1	2004	Iodide transport by thyrocytes involves two transporters, namely the Na(+)/I (-) symporter located at the basolateral pole and possibly pendrin in the apical membranes of the cell.	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	69-90
15001644-1	2004	Iodide transport by thyrocytes involves two transporters, namely the Na(+)/I (-) symporter located at the basolateral pole and possibly pendrin in the apical membranes of the cell.	Iodides	0-6	solute carrier family 26 member 4	Homo sapiens	136-143
14734652-0	2004	The Q267E mutation in the sodium/iodide symporter (NIS) causes congenital iodide transport defect (ITD) by decreasing the NIS turnover number.	Iodides	33-39	solute carrier family 5 member 5	Homo sapiens	122-125
14734652-1	2004	The Na(+)/I(-) symporter (NIS) is a key plasma membrane glycoprotein that mediates active iodide (I(-)) transport in the thyroid and other tissues.	Iodides	90-96	solute carrier family 5 member 5	Homo sapiens	4-24
14734652-1	2004	The Na(+)/I(-) symporter (NIS) is a key plasma membrane glycoprotein that mediates active iodide (I(-)) transport in the thyroid and other tissues.	Iodides	90-96	solute carrier family 5 member 5	Homo sapiens	26-29
14744818-7	2004	We found that VIP (EC(50) approximately 7.6 nM) and PACAP-27 (EC(50) approximately 10 nM) stimulated glibenclamide-sensitive and DIDS-insensitive iodide efflux in Calu-3 cells.	Iodides	146-152	vasoactive intestinal peptide	Homo sapiens	14-17
15062544-1	2004	A crucial step in thyroid hormone synthesis is the oxidative coupling of iodide to thyroglobulin that is catalyzed by thyroperoxidase.	Iodides	73-79	thyroid peroxidase	Homo sapiens	118-133
15611814-4	2004	Iodide oxidation and organification occur mainly in the thyrocyte apical surface and these reactions are catalyzed by thyroperoxidase (TPO) in the presence of hydrogen peroxide.	Iodides	0-6	thyroid peroxidase	Homo sapiens	118-133
15611814-4	2004	Iodide oxidation and organification occur mainly in the thyrocyte apical surface and these reactions are catalyzed by thyroperoxidase (TPO) in the presence of hydrogen peroxide.	Iodides	0-6	thyroid peroxidase	Homo sapiens	135-138
15611814-5	2004	Thus, thyroid iodide organification depends on TPO activity, which is modulated by the concentration of substrates (thyroglobulin and iodide) and cofactor (hydrogen peroxide).	Iodides	14-20	thyroid peroxidase	Homo sapiens	47-50
15611814-5	2004	Thus, thyroid iodide organification depends on TPO activity, which is modulated by the concentration of substrates (thyroglobulin and iodide) and cofactor (hydrogen peroxide).	Iodides	14-20	thyroglobulin	Homo sapiens	116-129
14729653-1	2004	Lactating breast tissue and some breast cancers express the sodium/iodide symporter (NIS) and concentrate iodide.	Iodides	67-73	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	85-88
15055360-2	2004	TPO abnormality is considered to be a major cause of congenital hypothyroidism (CH) with total iodide organification defect.	Iodides	95-101	thyroid peroxidase	Homo sapiens	0-3
15068624-2	2004	The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
15068624-2	2004	The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	215-218
15068624-2	2004	The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	215-218
15068624-2	2004	The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene.	Iodides	105-111	solute carrier family 5 member 5	Homo sapiens	29-32
14604989-7	2004	The GPA-deficient cells had a normal K(d) for iodide binding, in agreement with the unchanged K(m) found in transport studies.	Iodides	46-52	glycophorin A (MNS blood group)	Homo sapiens	4-7
14712300-1	2004	The sodium iodide symporter (NIS) mediates iodide uptake into thyrocytes and is the molecular basis of thyroid radioiodine therapy.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
15009910-1	2004	The sodium/iodide symporter (NIS) mediates active iodide uptake into thyroid follicular cells and is important for the diagnosis and radioiodide treatment of thyroid cancers.	Iodides	11-17	solute carrier family 5 member 5	Rattus norvegicus	29-32
14751036-0	2003	Thyroperoxidase gene mutations in congenital goitrous hypothyroidism with total and partial iodide organification defect.	Iodides	92-98	thyroid peroxidase	Homo sapiens	0-15
15062574-1	2003	The Na(+)/I(-) symporter (NIS) is a plasma membrane glycoprotein that mediates active iodide uptake in the thyroid-the essential first step in thyroid hormone biosynthesis-and in other tissues, such as salivary and lactating mammary glands.	Iodides	86-92	solute carrier family 5 member 5 L homeolog	Xenopus laevis	4-24
15062574-1	2003	The Na(+)/I(-) symporter (NIS) is a plasma membrane glycoprotein that mediates active iodide uptake in the thyroid-the essential first step in thyroid hormone biosynthesis-and in other tissues, such as salivary and lactating mammary glands.	Iodides	86-92	solute carrier family 5 member 5 L homeolog	Xenopus laevis	26-29
14640646-2	2003	This communication describes a simple catalyst system-Ni(cod)2/s-Bu-Pybox-that achieves room-temperature Negishi reactions of an array of functionalized primary and secondary alkyl bromides and iodides.	Iodides	194-201	COD2	Homo sapiens	57-62
12792733-5	2003	These hNIS-transduced cells actively transported iodide into the cytoplasm at the level of 11635.3, 61571.6, and 19367.5 pmoles/10(6) cells in ARO, FRO, and NPA, respectively.	Iodides	49-55	solute carrier family 5 member 5	Homo sapiens	6-10
14633711-4	2003	The ability of Ad-ARR(2)PB/hNIS to cause NIS expression in tumor cells was characterized by iodide uptake assay and compared with Ad-CMV/hNIS in which the h-NIS expression is driven by the cytomegalovirus (CMV) promoter.	Iodides	92-98	solute carrier family 5 member 5	Homo sapiens	28-31
14530519-0	2003	Pendrin transporter carries out iodide uptake into MCF-7 human mammary cancer cells.	Iodides	32-38	solute carrier family 26 member 4	Homo sapiens	0-7
12938097-1	2003	Thyroid peroxidase (TPO) defects, typically transmitted as autosomal recessive traits, result in hypothyroid goiters with failure to convert iodide into organic iodine.	Iodides	141-147	thyroid peroxidase	Homo sapiens	0-18
12938097-1	2003	Thyroid peroxidase (TPO) defects, typically transmitted as autosomal recessive traits, result in hypothyroid goiters with failure to convert iodide into organic iodine.	Iodides	141-147	thyroid peroxidase	Homo sapiens	20-23
12938097-2	2003	We analyzed the TPO gene in 14 unrelated patients with clinical evidence of iodide organification defects.	Iodides	76-82	thyroid peroxidase	Homo sapiens	16-19
14870777-1	2003	The sodium iodide symporter (NIS) is a plasma basolateral membrane protein that actively transports iodide to the thyroid follicular cells as the first step of thyroid hormone biosynthesis.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
14870777-2	2003	NIS also mediates active iodide transport in other human tissues including the salivary glands, lactating mammary gland and gastric mucosa.	Iodides	25-31	solute carrier family 5 member 5	Homo sapiens	0-3
12941836-3	2003	Expression of NIS and TPO facilitated concentration of iodide in tumors.	Iodides	55-61	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	14-17
12941836-3	2003	Expression of NIS and TPO facilitated concentration of iodide in tumors.	Iodides	55-61	thyroid peroxidase	Mus musculus	22-25
12941836-4	2003	As a consequence of the marked increase in intracellular levels of iodide, apoptosis was seen in &gt;95% of NIS/TPO-modified lung cancer cells.	Iodides	67-73	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	108-111
12941836-4	2003	As a consequence of the marked increase in intracellular levels of iodide, apoptosis was seen in &gt;95% of NIS/TPO-modified lung cancer cells.	Iodides	67-73	thyroid peroxidase	Mus musculus	112-115
12941836-8	2003	In addition, iodide-induced apoptosis is associated with overexpression of CDKN1A (p21/Waf1)and down-regulation of survivin at both mRNA and protein levels.	Iodides	13-19	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	75-81
12941836-8	2003	In addition, iodide-induced apoptosis is associated with overexpression of CDKN1A (p21/Waf1)and down-regulation of survivin at both mRNA and protein levels.	Iodides	13-19	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	83-86
12941836-8	2003	In addition, iodide-induced apoptosis is associated with overexpression of CDKN1A (p21/Waf1)and down-regulation of survivin at both mRNA and protein levels.	Iodides	13-19	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	87-91
12941836-9	2003	This is the first report demonstrating that a therapeutic dose of nonradioactive iodide has potent efficacy and high selectivity against lung cancer when used in combination with genetic modification of cancer cells to express the NIS/TPO genes.	Iodides	81-87	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	231-234
12941836-9	2003	This is the first report demonstrating that a therapeutic dose of nonradioactive iodide has potent efficacy and high selectivity against lung cancer when used in combination with genetic modification of cancer cells to express the NIS/TPO genes.	Iodides	81-87	thyroid peroxidase	Mus musculus	235-238
14572289-3	2003	Direct displacement of the anomeric iodide alleviates the need to introduce temporary C-2 stereodirecting groups that require subsequent removal.	Iodides	36-42	complement C2	Homo sapiens	86-89
12865321-1	2003	We reported recently the induction of androgen-dependent iodide uptake activity in the human prostatic adenocarcinoma cell line LNCaP using a prostate-specific antigen (PSA) promoter-directed expression of the sodium iodide symporter (NIS) gene.	Iodides	57-63	kallikrein related peptidase 3	Homo sapiens	142-173
12649158-8	2003	Tumor xenografts in severe combined immunodeficiency mice expressing hNIS could be imaged using iodine-123 (123I) and shown to retain iodide for up to 48 hours.	Iodides	134-140	solute carrier family 5 member 5	Homo sapiens	69-73
14502440-3	2003	CFTR activity was measured using the (125I) iodide efflux technique and whole-cell patch-clamp recording in response to either forskolin or xanthine derivatives.	Iodides	44-50	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	0-4
12792733-5	2003	These hNIS-transduced cells actively transported iodide into the cytoplasm at the level of 11635.3, 61571.6, and 19367.5 pmoles/10(6) cells in ARO, FRO, and NPA, respectively.	Iodides	49-55	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	143-146
12792733-7	2003	RT-PCR analysis revealed that the expression of genes related to iodide trapping (Tg, TSHR and TPO) was dramatically downregulated in these cells.	Iodides	65-71	thyroid stimulating hormone receptor	Homo sapiens	86-90
12792733-7	2003	RT-PCR analysis revealed that the expression of genes related to iodide trapping (Tg, TSHR and TPO) was dramatically downregulated in these cells.	Iodides	65-71	thyroid peroxidase	Homo sapiens	95-98
12792733-8	2003	The present study indicates that functional hNIS can be efficiently expressed and is responsible for active transport of iodide in hNIS-negative human thyroid cancer cells by a recombinant adenovirus.	Iodides	121-127	solute carrier family 5 member 5	Homo sapiens	44-48
12792733-8	2003	The present study indicates that functional hNIS can be efficiently expressed and is responsible for active transport of iodide in hNIS-negative human thyroid cancer cells by a recombinant adenovirus.	Iodides	121-127	solute carrier family 5 member 5	Homo sapiens	131-135
12792733-10	2003	Therefore, these kinetic characteristics of iodide uptake and efflux may limit the therapeutic potential of hNIS/radioiodide-based treatment following exogenous hNIS expression in human thyroid cancer.	Iodides	44-50	solute carrier family 5 member 5	Homo sapiens	108-112
12792733-10	2003	Therefore, these kinetic characteristics of iodide uptake and efflux may limit the therapeutic potential of hNIS/radioiodide-based treatment following exogenous hNIS expression in human thyroid cancer.	Iodides	44-50	solute carrier family 5 member 5	Homo sapiens	161-165
12704416-3	2003	hNIS-expressing cell lines accumulated up to 200 times more iodide when compared to wild-type cells.	Iodides	60-66	solute carrier family 5 member 5	Homo sapiens	0-4
12541134-14	2003	In conclusion, transduction of the hNIS gene under the control of the GLUT1 promoter element induces iodide transport in Morris hepatoma cells in vitro and in vivo.	Iodides	101-107	solute carrier family 2 member 1	Rattus norvegicus	70-75
12846418-5	2003	Combining a RAR with a RXR selective ligand enhanced both NIS mRNA expression and iodide uptake in MCF-7 cells.	Iodides	82-88	retinoic acid receptor alpha	Homo sapiens	12-15
12846418-5	2003	Combining a RAR with a RXR selective ligand enhanced both NIS mRNA expression and iodide uptake in MCF-7 cells.	Iodides	82-88	retinoid X receptor alpha	Homo sapiens	23-26
12846418-6	2003	Similarly, a ligand for proliferator-activated receptor gamma (PPARgamma) when combined with 9-cis RA synergistically increased both NIS mRNA levels and iodide uptake in these MCF-7 cells.	Iodides	153-159	peroxisome proliferator activated receptor gamma	Homo sapiens	24-73
12704416-5	2003	In rats, the hNIS-expressing tumors accumulated up to 20 times more iodide when compared to contralateral transplanted wild-type tumors.	Iodides	68-74	solute carrier family 5 member 5	Homo sapiens	13-17
12704416-8	2003	Although transduction of the hNIS gene induces iodide transport in rat prostate adenocarcinoma a rapid efflux occurs, which leads to a low absorbed dose in genetically modified tumors.	Iodides	47-53	solute carrier family 5 member 5	Homo sapiens	29-33
12727986-4	2003	Pendrin is an apical porter of iodide in the thyroid.	Iodides	31-37	solute carrier family 26 member 4	Homo sapiens	0-7
12914397-2	2003	The sodium iodide symporter NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyrioidal tissues, in particular lactating mammary gland.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	28-31
12639906-7	2003	Northern blot studies showed that iodide did not reduce DUOX2 mRNA levels but did reduce those of TPO and NIS.	Iodides	34-40	thyroid peroxidase	Sus scrofa	98-101
12639906-9	2003	Cyclic AMP increased the amount of the highly glycosylated form of Duox2, an effect antagonized by iodide in a methimazole-dependent manner.	Iodides	99-105	dual oxidase 2	Sus scrofa	67-72
12639906-10	2003	These data suggest that an oxidized form of iodide inhibits the H(2)O(2) generator at a posttranscriptional level by reducing the availability of the mature Duox2 protein.	Iodides	44-50	dual oxidase 2	Sus scrofa	157-162
12914397-3	2003	Because of its crucial role in the ability of thyroid follicular cells to trap iodide of NIS opened an exciting and extensivenew field of thyroid-related research.	Iodides	79-85	solute carrier family 5 member 5	Homo sapiens	89-92
12914397-5	2003	In addition, NIS-mediated iodide accumulation allows diagnostic thyroid scintigraphy as well as effective therapeutic application of radio-iodide in benign and malignant thyroid disease.	Iodides	26-32	solute carrier family 5 member 5	Homo sapiens	13-16
12612415-0	2003	Modification by fluoride, bromide, iodide, thiocyanate and nitrite anions of reaction of a myeloperoxidase-H2O2-Cl- system with nucleosides.	Iodides	35-41	myeloperoxidase	Homo sapiens	91-106
12588899-6	2003	Stimulation of iodide efflux by chlorophenylthio-cAMP (cpt-cAMP) was delayed in cells expressing 9CA channels, and a similar delay was observed when cells expressing wild-type CFTR were treated with the PKC inhibitor chelerythrine.	Iodides	15-21	CF transmembrane conductance regulator	Homo sapiens	176-180
12690461-8	2003	We conclude that these animals have established a specialised adaptive mechanism, most probably at the level of the Na(+)/I(-) symporter, that acts to enhance the uptake of dietary iodide into the gut and again from the serum into the follicular cells of the thyroid gland.	Iodides	181-187	solute carrier family 5 member 5	Homo sapiens	116-136
12489024-2	2003	The NIS mediates the normal physiological transport of iodide across the thyroid cell membrane.	Iodides	55-61	solute carrier family 5 member 5	Homo sapiens	4-7
12586784-1	2003	The sodium/iodide symporter (NIS) is a membrane protein mediating the active transport of iodide into the thyroid gland.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
12699587-1	2003	The sodium iodide symporter (NIS) mediates iodide uptake in thyroid cells and enables the effective radioiodide treatment of thyroid cancers.	Iodides	11-17	solute carrier family 5 member 5	Rattus norvegicus	29-32
14757960-1	2003	Thiocyanate [SCN-] is a complex anion which is a potent inhibitor of iodide transport.	Iodides	69-75	sorcin	Homo sapiens	13-16
12533525-8	2003	These results suggest that pendrin may play a role in thyroid hormone production as the apical porter of chloride/iodide and investigation of pendrin leads to a better understanding of functional aspects of the iodine transportation system in thyroid diseases.	Iodides	114-120	solute carrier family 26 member 4	Homo sapiens	27-34
12388138-3	2003	We now report the existence of a second iodide transporter, pendrin, which is also essential for iodide accumulation in milk.	Iodides	40-46	solute carrier family 26, member 4	Mus musculus	60-67
12388138-6	2003	The prolactin effect on iodide uptake into cultured mammary tissues was abolished by pendrin transport inhibitors, including DIDS, furosemide, and probenecid.	Iodides	24-30	solute carrier family 26, member 4	Mus musculus	85-92
12388138-7	2003	These studies suggest that the prolactin stimulation of pendrin activity is an essential element in the prolactin stimulation of iodide uptake into milk.	Iodides	129-135	solute carrier family 26, member 4	Mus musculus	56-63
12705478-1	2003	The function of the sodium iodide symporter (Na(+)/I(-), (NIS), a membrane protein that mediates iodide transport into cells, is the best described in the thyroid cells.	Iodides	27-33	solute carrier family 5 member 5	Homo sapiens	58-61
12457457-0	2002	Prevention of lymphocytic thyroiditis in iodide-treated non-obese diabetic mice lacking interferon regulatory factor-1.	Iodides	41-47	interferon regulatory factor 1	Mus musculus	88-118
12475396-1	2002	BACKGROUND: Sodium/iodide symporter (NIS) is a key protein in iodide transport by thyroid cells and this activity is a prerequisite for effective radioiodide treatment of thyroid cancer.	Iodides	19-25	solute carrier family 5 member 5	Homo sapiens	37-40
12475396-2	2002	In the majority of thyroid cancers, however, iodide uptake is reduced, probably as a result of decreased NIS protein expression.	Iodides	45-51	solute carrier family 5 member 5	Homo sapiens	105-108
12475396-6	2002	CONCLUSION: These observations raise the possibility that NIS expression, and subsequently iodide transport, are reduced in thyroid tumors at least in part owing to alterations in the binding activity of AP2 and Sp1 transcription factors to NIS promoter.	Iodides	91-97	transcription factor AP-2 alpha	Homo sapiens	204-207
12432094-7	2002	Thyroid glands of TSHR-KO mice produced uniodinated thyroglobulin, but the ability to concentrate and organify iodide could be restored to TSHR-KO thyroids when cultured in the presence of the adenylate cyclase agonist forskolin.	Iodides	111-117	thyroid stimulating hormone receptor	Mus musculus	18-22
12457457-9	2002	Iodide treatment induced LT in more than 80% of IRF-1 +/+ and +/- mice.	Iodides	0-6	interferon regulatory factor 1	Mus musculus	48-53
12457457-13	2002	CONCLUSIONS: IRF-1 is involved in the development of iodide-induced LT in NOD mice.	Iodides	53-59	interferon regulatory factor 1	Mus musculus	13-18
12269834-4	2002	At pH 7 and 15 degrees C, the two-electron reduction of compound I to native LPO by bromide and iodide has a second-order rate constant of (4.1 +/- 0.1) x 10(4) M(-1) s(-1) and (1.2 +/- 0.04) x 10(8) M(-1) s(-1), respectively.	Iodides	96-102	lactoperoxidase	Homo sapiens	77-80
12432093-6	2002	These data suggest that the major role of the TSH/TSHR pathway is in controlling genes involved in iodide metabolism such as sodium/iodide symporter and thyroperoxidase.	Iodides	99-105	thyroid stimulating hormone receptor	Mus musculus	50-54
12397014-7	2002	We report that H146, H345, and H727 express CFTR messenger RNA (reverse transcription polymerase chain reaction) and protein (immunoblotting) and possess functional CFTR Cl(-) conductance, demonstrated by an iodide efflux assay inhibitable by transfection with antisense CFTR.	Iodides	208-214	CF transmembrane conductance regulator	Homo sapiens	165-169
12397014-7	2002	We report that H146, H345, and H727 express CFTR messenger RNA (reverse transcription polymerase chain reaction) and protein (immunoblotting) and possess functional CFTR Cl(-) conductance, demonstrated by an iodide efflux assay inhibitable by transfection with antisense CFTR.	Iodides	208-214	CF transmembrane conductance regulator	Homo sapiens	165-169
12390328-1	2002	The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
12390328-2	2002	Because of its crucial role in the ability of thyroid follicular cells to trap iodide, cloning of NIS opened an exciting and extensive new field of thyroid-related research.	Iodides	79-85	solute carrier family 5 member 5	Homo sapiens	98-101
12390328-4	2002	In addition to its key function in thyroid physiology, NIS-mediated iodide accumulation allows diagnostic thyroid scintigraphy as well as effective therapeutic application of radioiodine in benign and malignant thyroid disease.	Iodides	68-74	solute carrier family 5 member 5	Homo sapiens	55-58
12444898-9	2002	CONCLUSION: Our data demonstrated that hCG stimulates iodide uptake in FRTL-5 cells by increasing NIS mRNA and protein levels.	Iodides	54-60	chorionic gonadotropin subunit beta 5	Homo sapiens	39-42
12444898-1	2002	BACKGROUND: Various clinical and experimental findings support the concept that human chorionic gonadotropin (hCG) can stimulate iodide uptake in thyroid cells.	Iodides	129-135	chorionic gonadotropin subunit beta 5	Homo sapiens	110-113
12444898-2	2002	DESIGN: We investigated the molecular mechanisms underlying the effects of hCG on iodide uptake, and particularly its action on the expression of Na+/I- symporter (NIS) mRNA and protein.	Iodides	82-88	chorionic gonadotropin subunit beta 5	Homo sapiens	75-78
12444898-5	2002	RESULTS: Iodide uptake was increased by hCG in a dose- and time-dependent manner: maximal effects were observed after 72 h of stimulation.	Iodides	9-15	chorionic gonadotropin subunit beta 5	Homo sapiens	40-43
12381453-1	2002	The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types.	Iodides	38-44	solute carrier family 5 member 5	Homo sapiens	56-59
12354788-2	2002	Mutations in the transmembrane protein, pendrin, cause diminished export of iodide from thyroid follicular cells to the colloid and are associated with the syndrome.	Iodides	76-82	solute carrier family 26 member 4	Homo sapiens	40-47
12224970-10	2002	The best mediator, based on tris(4,4"-di-tert-butyl-2,2"-dipyridyl)cobalt(II/III) perchlorate, resulted in DSSCs exhibiting efficiencies within 80% of that of a comparable iodide/triiodide-mediated DSSC.	Iodides	172-178	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	77-80
12396625-3	2002	The Na/I symporter (NIS) gene is expressed mainly in the thyroid and is responsible for iodide accumulation in this organ.	Iodides	88-94	solute carrier family 5 member 5	Homo sapiens	4-18
12396625-3	2002	The Na/I symporter (NIS) gene is expressed mainly in the thyroid and is responsible for iodide accumulation in this organ.	Iodides	88-94	solute carrier family 5 member 5	Homo sapiens	20-23
12028133-1	2002	UNLABELLED: The sodium (Na+)/iodide (I-)-symporter (NIS) is abundantly expressed and accumulates iodide in thyroid follicular cells.	Iodides	97-103	solute carrier family 5 member 5	Rattus norvegicus	52-55
12107249-0	2002	Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells.	Iodides	14-20	solute carrier family 26 member 4	Homo sapiens	0-7
12107249-0	2002	Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells.	Iodides	60-66	solute carrier family 26 member 4	Homo sapiens	0-7
12107249-2	2002	Although pendrin was shown to transport iodide and chloride using Xenopus laevis oocytes and Sf9 insect cells, there is no report using mammalian cells to study its role in thyroid function.	Iodides	40-46	solute carrier family 26 member 4 gene 3 S homeolog	Xenopus laevis	9-16
12107249-3	2002	We show here, using COS-7 cells and Chinese hamster ovary cells transfected with expression vectors encoding sodium iodide symporter or human Pendred syndrome gene cDNA and by comparison with studies using rat thyroid FRTL-5 cells, that pendrin is an iodide-specific transporter in mammalian cells and is responsible for iodide efflux in the thyroid.	Iodides	251-257	solute carrier family 26 member 4	Rattus norvegicus	237-244
12201788-2	2002	Under the catalysis of 1 mol % Pd(PPh3)4, the reaction of 4,4-disubstituted 2,3-allenamides and organic iodides in toluene afforded iminolactones stereospecifically in &gt;90% yields using K2CO3 (2 equiv)-5 mol % TBAB as the base.	Iodides	104-111	caveolin 1	Homo sapiens	34-38
12136135-5	2002	Iodide replaces a water molecule at the surface of the S100A3 protein, whereas xenon binds in a hydrophobic cavity at the dimer interface.	Iodides	0-6	S100 calcium binding protein A3	Homo sapiens	55-61
12161518-2	2002	These were the only cases reported to date who received long-term iodide treatment over 10 yr. We examined the sodium/iodide symporter (NIS) gene of these patients.	Iodides	66-72	solute carrier family 5 member 5	Homo sapiens	136-139
12110737-6	2002	RESULTS: The one patient with permanent and severe thyroid hormone deficiency and a complete iodide-organification defect had a homozygous nonsense mutation in the THOX2 gene that eliminates all functional domains of the protein.	Iodides	93-99	dual oxidase 2	Homo sapiens	164-169
12110737-7	2002	Three of the eight patients with mild transient congenital hypothyroidism and a partial iodide-organification defect had heterozygous mutations in the THOX2 gene that prematurely truncate the protein, thus abolishing its functional domains.	Iodides	88-94	dual oxidase 2	Homo sapiens	151-156
12047906-0	2002	Atrial natriuretic peptide inhibits iodide uptake and thyroglobulin messenger ribonucleic acid expression in cultured bovine thyroid follicles.	Iodides	36-42	natriuretic peptide A	Bos taurus	0-26
12028133-1	2002	UNLABELLED: The sodium (Na+)/iodide (I-)-symporter (NIS) is abundantly expressed and accumulates iodide in thyroid follicular cells.	Iodides	29-35	solute carrier family 5 member 5	Rattus norvegicus	52-55
12028133-5	2002	The role of gastric NIS is enigmatic and we aimed to unravel its possible involvement in iodide transport.	Iodides	89-95	solute carrier family 5 member 5	Rattus norvegicus	20-23
12028133-15	2002	An entero-thyroidal circulation of iodide mediated principally by gastric NIS, but possibly also by NIS in salivary glands is suggested.	Iodides	35-41	solute carrier family 5 member 5	Rattus norvegicus	74-77
12028133-15	2002	An entero-thyroidal circulation of iodide mediated principally by gastric NIS, but possibly also by NIS in salivary glands is suggested.	Iodides	35-41	solute carrier family 5 member 5	Rattus norvegicus	100-103
12021185-4	2002	Functional analysis clearly showed that Jar cells are able to concentrate iodide in presence of hCG.	Iodides	74-80	chorionic gonadotropin subunit beta 5	Homo sapiens	96-99
11978100-4	2002	The second one is a 1-electron reduction process, followed by an iodide elimination, then by a second 1-electron step (ECE mechanism) to generate the same final product.	Iodides	65-71	endothelin converting enzyme 1	Homo sapiens	119-122
12021185-7	2002	In conclusion, our data demonstrate that 1) NIS is expressed in JAr cells; 2) iodide transport in JAr cells is regulated by hCG and by cAMP-dependent and -independent mechanisms; 3) the stimulation of iodide uptake is due to an increase in both NIS mRNA and protein levels; and 4) JAr cells may represent an excellent in vitro model suitable to analyze the molecular mechanisms involved in iodide transport from mother to fetus.	Iodides	78-84	chorionic gonadotropin subunit beta 5	Homo sapiens	124-127
12021185-5	2002	Iodide accumulation increased after 2-h exposure to 5 IU/ml hCG, to 6-fold over the basal level after 8 h. This effect was reproduced using forskolin, the cAMP analog (Bu)(2)-cAMP, and phorbol acetate.	Iodides	0-6	chorionic gonadotropin subunit beta 5	Homo sapiens	60-63
11978100-6	2002	The reoxidation of the Pd(3)(dppm)(3)(CO)(0) cluster in the presence of iodide proceeds via a pure ECE pathway.	Iodides	72-78	endothelin converting enzyme 1	Homo sapiens	99-102
11887206-0	2002	Effect of iodide on Fas, Fas-ligand and Bcl-w mRNA expression in thyroid of NOD mice pretreated with methimazole.	Iodides	10-16	BCL2-like 2	Mus musculus	40-45
12012191-1	2002	A simple and rapid procedure, utilising constant-current stripping analysis (CCSA) at a carbon-paste electrode containing tricresyl phosphate as a pasting liquid (TCP-CPE), has been developed for the determination of iodide in table salt.	Iodides	217-223	carboxypeptidase E	Homo sapiens	167-170
11932316-4	2002	PDS is thought to enable efflux iodide into the follicle lumen.	Iodides	32-38	solute carrier family 26 member 4	Homo sapiens	0-3
11932316-9	2002	Iodide efflux assays were performed using human embryonic kidney 293 cells transfected with mutant pendrin and cotransfected with sodium iodide transporter to provide a mechanism of iodide uptake.	Iodides	0-6	solute carrier family 26 member 4	Homo sapiens	99-106
11919333-2	2002	It codes for a transmembrane protein called pendrin, which is highly expressed at the apical surface of the thyroid cell and functions as a transporter of chloride and iodide.	Iodides	168-174	solute carrier family 26 member 4	Homo sapiens	44-51
11932304-3	2002	It has been postulated that in the thyroid pendrin could participate in the transport of iodide from the cell to the lumen of follicles.	Iodides	89-95	solute carrier family 26 member 4	Homo sapiens	43-50
11887206-2	2002	Some authors have proposed that iodide, given after methimazole or propylthiouracil, is capable of inducing apoptosis in thyroid cells and that anti-thyroid drugs can modulate the expression of apoptosis components such as Fas and its ligand (Fas-L).	Iodides	32-38	Fas ligand (TNF superfamily, member 6)	Mus musculus	243-248
11779571-5	2002	A blue shift of 10 nm was observed for [Nle(4),D-Phe(7)]-alpha-MSH which was correlated with an increase in fluorescence anisotropy and with changes in the accessibility of the coupled peptide as assessed by the quenching of fluorescence of its tryptophan residue by iodide (Stern-Volmer plots).	Iodides	267-273	proopiomelanocortin	Homo sapiens	57-66
11889195-2	2002	However, loss of iodide uptake is frequently observed in metastasized thyroid cancer, which may be explained by diminished expression of the human sodium-iodide symporter (hNIS).	Iodides	17-23	solute carrier family 5 member 5	Homo sapiens	172-176
11889195-3	2002	We studied whether transfection of hNIS into the hNIS-deficient follicular thyroid carcinoma cell line FTC133 restores the in vivo iodide accumulation in xenografted tumors and their susceptibility to radioiodide therapy.	Iodides	131-137	solute carrier family 5 member 5	Homo sapiens	35-39
11889195-12	2002	We conclude that hNIS transfection into a hNIS-defective thyroid carcinoma cell line restores the in vivo iodide accumulation.	Iodides	106-112	solute carrier family 5 member 5	Homo sapiens	17-21
11889195-12	2002	We conclude that hNIS transfection into a hNIS-defective thyroid carcinoma cell line restores the in vivo iodide accumulation.	Iodides	106-112	solute carrier family 5 member 5	Homo sapiens	42-46
11874711-1	2002	Total iodide organification defect (TIOD), where the iodide in the thyroid gland cannot be oxidized and/or bound to the protein, is caused by a defect in the thyroid peroxidase (TPO) gene.	Iodides	6-12	thyroid peroxidase	Homo sapiens	158-176
11874711-1	2002	Total iodide organification defect (TIOD), where the iodide in the thyroid gland cannot be oxidized and/or bound to the protein, is caused by a defect in the thyroid peroxidase (TPO) gene.	Iodides	6-12	thyroid peroxidase	Homo sapiens	178-181
11836344-1	2002	Expression of the Pendred syndrome gene (PDS/Pds) is thought to be responsible for the iodide transport in the thyroid as well as the formation and function of the inner ear.	Iodides	87-93	solute carrier family 26 member 4	Homo sapiens	41-44
11836344-1	2002	Expression of the Pendred syndrome gene (PDS/Pds) is thought to be responsible for the iodide transport in the thyroid as well as the formation and function of the inner ear.	Iodides	87-93	solute carrier family 26 member 4	Homo sapiens	45-48
11788674-4	2002	A defect in the expression or structure of the sodium iodide symporter (NIS) gene has been hypothesized as a possible cause of the impaired iodide trapping in nonfunctioning thyroid nodules.	Iodides	54-60	solute carrier family 5 member 5	Homo sapiens	72-75
11534731-5	2001	Chloride and bromide converted MeHg+ into Hg0, whereas iodide caused transformation into Hg2+ and Hg0.	Iodides	55-61	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	89-92
11735595-1	2001	[reaction: see text] Palladium-catalyzed cross-coupling reaction of triarylbismuths with aryl bromides, iodides, and triflates proceeded efficiently in the presence of K(2)CO(3) or CsF.	Iodides	104-111	colony stimulating factor 2	Homo sapiens	181-184
11720877-0	2001	Sodium/iodide symporter (NIS) and pendrin are expressed differently in hot and cold nodules of thyroid toxic multinodular goiter.	Iodides	7-13	solute carrier family 5 member 5	Homo sapiens	25-28
11681960-2	2001	A more general Pd(0) catalyst/ligand system has been developed that activates bromides and iodides: palladium(0) dibenzylideneacetone (Pd(dba)(2)) is activated with 2-(di-tert-butylphosphino)biphenyl (Buchwald"s ligand) (1:2 mol ratio of Pd/phosphine).	Iodides	91-98	loss of heterozygosity, 19, chromosomal region 1	Homo sapiens	138-141
11517148-7	2001	Na(+)/I(-) symporter mRNA was detected in the fetal thyroid of supplemented with iodide and increased about 2- and 4- fold in the thyroid of fetuses from a low iodine diet, not supplemented, and one supplemented with perchlorate, respectively.	Iodides	81-87	solute carrier family 5 member 5	Rattus norvegicus	0-20
11500239-0	2001	Iodide organification defects resulting from cosegregation of mutated and null thyroid peroxidase alleles.	Iodides	0-6	thyroid peroxidase	Homo sapiens	79-97
11500239-1	2001	This report describes an intriguing combination of the thyroid peroxidase (TPO) alleles resulting in an iodide organification defect.	Iodides	104-110	thyroid peroxidase	Homo sapiens	55-73
11500239-1	2001	This report describes an intriguing combination of the thyroid peroxidase (TPO) alleles resulting in an iodide organification defect.	Iodides	104-110	thyroid peroxidase	Homo sapiens	75-78
11431151-2	2001	With the purpose of using the mouse as an animal model to analyse the role of the sodium iodide symporter (NIS) in iodide transport and its regulation in the mammary gland, mouse NIS (mNIS) cDNA was isolated from lactating mice.	Iodides	89-95	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	107-110
11431151-4	2001	Expression of mNIS in cultured mammalian cells induced cellular iodide accumulation.	Iodides	64-70	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	14-18
11262417-3	2001	The compounds were screened for their ability to activate CFTR at 50 microm concentration by measurement of the kinetics of iodide influx in Fisher rat thyroid cells expressing wild-type or G551D CFTR together with the green fluorescent protein-based halide indicator YFP-H148Q.	Iodides	124-130	CF transmembrane conductance regulator	Homo sapiens	58-62
11096079-6	2001	Antisense ClC-2-transfected monolayers of Caco-2 cells exhibited less chloride secretion (monitored as iodide efflux) than did mock transfected monolayers, providing the first direct molecular evidence that ClC-2 can contribute to chloride secretion by the human intestinal epithelium.	Iodides	103-109	chloride voltage-gated channel 2	Homo sapiens	10-15
11375697-3	2001	The iodide derivatives Dipp(2)nacnacMI(2) (M = Al (4), Ga (6), In (9)), which are useful for reduction to afford M(I) species, were made by a variety of routes.	Iodides	4-10	nudix hydrolase 3	Homo sapiens	23-27
11383870-1	2001	Human thyroperoxidase (hTPO) is critical for the accumulation of iodide in thyroid tissues.	Iodides	65-71	thyroid peroxidase	Homo sapiens	6-21
11383870-1	2001	Human thyroperoxidase (hTPO) is critical for the accumulation of iodide in thyroid tissues.	Iodides	65-71	thyroid peroxidase	Homo sapiens	23-27
11407580-3	2001	Iodide was converted to iodine, then sequestered with starch, and separated from the matrix using a Shim-pack DIOL-150 (250 x 7.9 mm) size exclusion column with methanol-0.01 mol l(-1) aqueous phosphoric acid (10:90, v/v) as mobile phase at 1.2 ml min(-1) and UV detection at 224 nm.	Iodides	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	248-254
11396699-1	2001	The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine.	Iodides	25-31	thyroglobulin	Homo sapiens	127-140
11396699-1	2001	The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine.	Iodides	25-31	thyroglobulin	Homo sapiens	142-144
11096079-6	2001	Antisense ClC-2-transfected monolayers of Caco-2 cells exhibited less chloride secretion (monitored as iodide efflux) than did mock transfected monolayers, providing the first direct molecular evidence that ClC-2 can contribute to chloride secretion by the human intestinal epithelium.	Iodides	103-109	chloride voltage-gated channel 2	Homo sapiens	207-212
11357333-4	2001	For alpha-actinin such a dynamic quencher is anionic iodide.	Iodides	53-59	actinin alpha 1	Homo sapiens	4-17
11248751-1	2001	OBJECTIVE: The expression of two recently identified iodide transporters, namely the sodium/iodide symporter (NIS) and pendrin, the product of the gene responsible for the Pendred syndrome (PDS), was studied in a series of various extra-thyroidal human tissues, and especially in those known to concentrate iodide.	Iodides	53-59	solute carrier family 26 member 4	Homo sapiens	119-126
11248751-1	2001	OBJECTIVE: The expression of two recently identified iodide transporters, namely the sodium/iodide symporter (NIS) and pendrin, the product of the gene responsible for the Pendred syndrome (PDS), was studied in a series of various extra-thyroidal human tissues, and especially in those known to concentrate iodide.	Iodides	53-59	solute carrier family 26 member 4	Homo sapiens	190-193
11327880-1	2001	Thyroperoxidase (TPO), a type I transmembrane heme containing glycoprotein, catalyzes iodide organification and thyroid hormone synthesis.	Iodides	86-92	thyroid peroxidase	Homo sapiens	0-15
11231356-1	2001	BACKGROUND: The human sodium iodide symporter (hNIS) is a transmembrane protein that mediates the active transport of iodide in the thyroid gland.	Iodides	29-35	solute carrier family 5 member 5	Homo sapiens	47-51
11231356-2	2001	Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.	Iodides	117-123	solute carrier family 5 member 5	Homo sapiens	21-24
11231356-2	2001	Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.	Iodides	117-123	solute carrier family 5 member 5	Homo sapiens	26-29
11231356-2	2001	Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.	Iodides	117-123	solute carrier family 5 member 5	Homo sapiens	26-29
11231356-3	2001	METHODS: The aim of this study was to examine functional hNIS expression in kidney by reverse transcription-polymerase chain reaction (RT-PCR), ribonuclease protection assay (RPA), immunohistochemistry, and Western blot analysis accompanied by iodide accumulation studies in kidney cells.	Iodides	244-250	solute carrier family 5 member 5	Homo sapiens	57-61
11231356-10	2001	CONCLUSIONS: Functional hNIS expression was demonstrated in the renal tubular system, suggesting that renal iodide transport may be, at least in part, an active process driven by NIS.	Iodides	108-114	solute carrier family 5 member 5	Homo sapiens	24-28
11231356-10	2001	CONCLUSIONS: Functional hNIS expression was demonstrated in the renal tubular system, suggesting that renal iodide transport may be, at least in part, an active process driven by NIS.	Iodides	108-114	solute carrier family 5 member 5	Homo sapiens	25-28
11458618-1	2001	BACKGROUND: Thyroid Na+/I- symporter (NIS) is thought to play an important role in iodide uptake in thyrocytes.	Iodides	83-89	solute carrier family 5 member 5	Homo sapiens	20-36
11458618-1	2001	BACKGROUND: Thyroid Na+/I- symporter (NIS) is thought to play an important role in iodide uptake in thyrocytes.	Iodides	83-89	solute carrier family 5 member 5	Homo sapiens	38-41
11327880-1	2001	Thyroperoxidase (TPO), a type I transmembrane heme containing glycoprotein, catalyzes iodide organification and thyroid hormone synthesis.	Iodides	86-92	serine incorporator 5	Homo sapiens	17-20
11182750-2	2001	We have recently reported that large doses of iodide given to rats chronically decrease the sodium/iodide symporter (NIS) mRNA and protein, suggesting that escape is due to a decrease in NIS and subsequent iodide transport.	Iodides	46-52	solute carrier family 5 member 5	Rattus norvegicus	92-115
11216532-0	2001	Transfer of the human NaI symporter gene enhances iodide uptake in hepatoma cells.	Iodides	50-56	solute carrier family 5 member 5	Homo sapiens	22-35
11216532-2	2001	The transport of iodide across the cell membrane is mediated by the human NaI symporter (hNIS).	Iodides	17-23	solute carrier family 5 member 5	Homo sapiens	74-87
11216532-3	2001	We therefore investigated whether the accumulation of iodide may be induced by the retroviral transfer of the hNIS gene in nonthyroid tumor cells.	Iodides	54-60	solute carrier family 5 member 5	Homo sapiens	110-114
11216532-2	2001	The transport of iodide across the cell membrane is mediated by the human NaI symporter (hNIS).	Iodides	17-23	solute carrier family 5 member 5	Homo sapiens	89-93
11216532-12	2001	In rats, the hNIS-expressing tumors accumulated six times more iodide than did the contralateral wild-type tumor as monitored by scintigraphy.	Iodides	63-69	solute carrier family 5 member 5	Homo sapiens	13-17
11170832-5	2001	We conclude that NIS is expressed in placenta and may mediate placental iodide transport.	Iodides	72-78	solute carrier family 5 member 5	Homo sapiens	17-20
11170631-7	2001	When bound to CCR1 or CCR5 receptors, the fluorescence signal of Flu-MIP-1alpha was quenched by collision with iodide indicating that the N-terminal end of MIP-1alpha is accessible to the solvent.	Iodides	111-117	C-C chemokine receptor type 5	Cricetulus griseus	22-26
11137035-0	2001	Effects of thyroglobulin and pendrin on iodide flux through the thyrocyte.	Iodides	40-46	thyroglobulin	Homo sapiens	11-24
11573132-4	2001	A candidate for the apical iodide-permeating mechanism is pendrin, a chloride/iodide transporting protein recently identified in the apical membrane.	Iodides	27-33	solute carrier family 26 member 4	Homo sapiens	58-65
11573133-0	2001	The role of pendrin in iodide regulation.	Iodides	23-29	solute carrier family 26 member 4	Homo sapiens	12-19
11573133-4	2001	Despite its high homology to known sulfate transporters, pendrin has been shown to transport iodide and chloride, but not sulfate.	Iodides	93-99	solute carrier family 26 member 4	Homo sapiens	57-64
11573135-0	2001	Transcriptional regulation of the human sodium/iodide symporter gene by Pax8 and TTF-1.	Iodides	47-53	paired box 8	Homo sapiens	72-76
11573135-0	2001	Transcriptional regulation of the human sodium/iodide symporter gene by Pax8 and TTF-1.	Iodides	47-53	transcription termination factor 1	Homo sapiens	81-86
11573136-4	2001	IL-6 has no effect on NIS functional activity, whereas IL-1beta suppresses iodide accumulation.	Iodides	75-81	interleukin 1 beta	Homo sapiens	55-63
11573141-1	2001	The uptake of iodide in thyroid epithelial cells is mediated by the sodium/iodide symporter (NIS).	Iodides	14-20	solute carrier family 5 member 5	Homo sapiens	93-96
11573141-3	2001	Loss of iodide uptake due to diminished expression of the human NIS (hNIS) is frequently observed in metastasized thyroid cancer.	Iodides	8-14	solute carrier family 5 member 5	Homo sapiens	64-67
11573141-3	2001	Loss of iodide uptake due to diminished expression of the human NIS (hNIS) is frequently observed in metastasized thyroid cancer.	Iodides	8-14	solute carrier family 5 member 5	Homo sapiens	69-73
11573141-9	2001	Iodide uptake in the hNIS transfected tumor was much higher than in non-transfected tumor, but a rapid release of radioactivity from the hNIS transfected tumor was observed.	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	21-25
11573143-2	2001	The transport of iodide across the cell membrane is mediated by the sodium iodide symporter (hNIS).	Iodides	17-23	solute carrier family 5 member 5	Homo sapiens	93-97
11573143-7	2001	In rats, the hNIS-expressing tumors accumulated six times more iodide as compared to the contralateral wild type tumor as monitored by scintigraphy.	Iodides	63-69	solute carrier family 5 member 5	Homo sapiens	13-17
11573143-11	2001	For a therapeutic application of the hNIS gene, however, additional conditions need to be defined which inhibit the iodide efflux.	Iodides	116-122	solute carrier family 5 member 5	Homo sapiens	37-41
11137035-0	2001	Effects of thyroglobulin and pendrin on iodide flux through the thyrocyte.	Iodides	40-46	solute carrier family 26 member 4	Homo sapiens	29-36
11078986-6	2000	Five of these metastatic lymph nodes were positive at the post-treatment total-body iodine-131 scan; in the other three, the total-body scan showed no uptake in the metastatic tissues, indicating an alteration downstream to the NIS mRNA synthesis causing the loss of iodide uptake.	Iodides	267-273	solute carrier family 5 member 5	Homo sapiens	228-231
11112545-9	2000	Iodide [(9.3 +/- 0.7) x 10(7) M(-1) s(-1)] is shown to be a better electron donor than bromide [(1.9 +/- 0.1) x 10(7) M(-1) s(-1)], whereas chloride oxidation by EPO compound I is extremely slow [(3.1 +/- 0.3) x 10(3) M(-1) s(-1)].	Iodides	0-6	eosinophil peroxidase	Homo sapiens	162-165
11228531-2	2000	We observed perchlorate-inhibitable iodide uptake up to 41-fold over control in all NIS-transfected cells.	Iodides	36-42	solute carrier family 5 member 5	Homo sapiens	84-87
11077054-10	2000	The presence of SULT1C1 in the adult thyroid gland raises the possibilities that the enzyme can contribute to intraglandular thyroid hormone processing and iodide reutilization.	Iodides	156-162	sulfotransferase family 1C member 2	Homo sapiens	16-23
11128720-0	2000	Reestablishment of in vitro and in vivo iodide uptake by transfection of the human sodium iodide symporter (hNIS) in a hNIS defective human thyroid carcinoma cell line.	Iodides	40-46	solute carrier family 5 member 5	Homo sapiens	108-112
11128720-0	2000	Reestablishment of in vitro and in vivo iodide uptake by transfection of the human sodium iodide symporter (hNIS) in a hNIS defective human thyroid carcinoma cell line.	Iodides	40-46	solute carrier family 5 member 5	Homo sapiens	119-123
11128720-2	2000	However, loss of iodide uptake is frequently observed in metastasized thyroid cancer, which may be explained by diminished expression of the human sodium iodide symporter (hNIS).	Iodides	17-23	solute carrier family 5 member 5	Homo sapiens	172-176
11128720-6	2000	hNIS mRNA expression corresponded with iodide uptake in semiquantitative polymerase chain reaction.	Iodides	39-45	solute carrier family 5 member 5	Homo sapiens	0-4
11128720-9	2000	Iodide uptake in the hNIS transfected tumor was much higher than in the nontransfected tumor, which corresponded with hNIS mRNA expression in tumors.	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	21-25
11128720-9	2000	Iodide uptake in the hNIS transfected tumor was much higher than in the nontransfected tumor, which corresponded with hNIS mRNA expression in tumors.	Iodides	0-6	solute carrier family 5 member 5	Homo sapiens	118-122
11052075-1	2000	Nefopam methohalide (chloride, bromide, and iodide) medium-ring quaternary ammonium salts of the non-narcotic analgesic tertiary amine drug give crystals belonging to the identical monoclinic P2(1)/c space group, and all of these pseudopolymorphs exhibit the same packing motif.	Iodides	44-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	192-197
11001757-2	2000	In earlier studies from our laboratory, we have shown that prolactin (PRL) enhances iodide accumulation by two- to threefold in cultured mammary tissues taken from pregnant mice.	Iodides	84-90	prolactin	Mus musculus	59-68
11001757-2	2000	In earlier studies from our laboratory, we have shown that prolactin (PRL) enhances iodide accumulation by two- to threefold in cultured mammary tissues taken from pregnant mice.	Iodides	84-90	prolactin	Mus musculus	70-73
11001757-7	2000	These studies suggest that the PRL stimulation of iodide accumulation in milk is mediated, at least in part, by the PRL stimulation of NIS accumulation in mammary gland tissues.	Iodides	50-56	prolactin	Mus musculus	31-34
11001757-7	2000	These studies suggest that the PRL stimulation of iodide accumulation in milk is mediated, at least in part, by the PRL stimulation of NIS accumulation in mammary gland tissues.	Iodides	50-56	prolactin	Mus musculus	116-119
11061560-0	2000	Rarity of anti- Na+/I- symporter (NIS) antibody with iodide uptake inhibiting activity in autoimmune thyroid diseases (AITD).	Iodides	53-59	solute carrier family 5 member 5	Homo sapiens	16-32
11227215-4	2000	It is shown that PC12 cells that stably overexpress Bcl-2 are protected against the toxic effect of taxol, as evidenced by the XTT assay and by a decreased fraction of propididum iodide positive cells in a dye exclusion test.	Iodides	179-185	BCL2, apoptosis regulator	Rattus norvegicus	52-57
11061528-0	2000	Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update).	Iodides	103-109	thyroid peroxidase	Homo sapiens	75-78
11061528-1	2000	Presented is a cohort study to assess the nature and frequency of thyroid peroxidase (TPO) mutations in 45 patients (35 families) with congenital hypothyroidism due to a total iodide organification defect; incidence is 1:66,000 in The Netherlands.	Iodides	176-182	thyroid peroxidase	Homo sapiens	86-89
11061560-0	2000	Rarity of anti- Na+/I- symporter (NIS) antibody with iodide uptake inhibiting activity in autoimmune thyroid diseases (AITD).	Iodides	53-59	solute carrier family 5 member 5	Homo sapiens	34-37
11061528-8	2000	Mutations in the TPO gene result in total iodide organification defects.	Iodides	42-48	thyroid peroxidase	Homo sapiens	17-20
11061560-2	2000	Prior to cloning of NIS, Raspe et al found iodide uptake inhibiting sera were rare in autoimmune thyroid diseases (AITD) while post-cloning, others reported the presence of antibody in 12-15% of Hashimoto"s thyroiditis (HT) and 30-84% of Graves" disease (GD).	Iodides	43-49	solute carrier family 5 member 5	Homo sapiens	20-23
10965033-8	2000	Matrilysin contains four tryptophyls, and their states were examined by fluorescence-quenching with iodide and cesium ions and acrylamide.	Iodides	100-106	matrix metallopeptidase 7	Homo sapiens	0-10
10782045-0	2000	Prolactin stimulation of iodide uptake and incorporation into protein is polyamine-dependent in mouse mammary gland explants.	Iodides	25-31	prolactin	Mus musculus	0-9
10890895-1	2000	The sodium/iodide symporter (NIS) stimulates iodide uptake in normal lactating breast, but is not known to be active in nonlactating breast or breast cancer.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
10910060-1	2000	The Na+/I- symporter (NIS) present in the membranes of thyroid cells is responsible for the capacity of the thyroid to concentrate iodide.	Iodides	131-137	solute carrier family 5 member 5	Homo sapiens	4-20
10910060-1	2000	The Na+/I- symporter (NIS) present in the membranes of thyroid cells is responsible for the capacity of the thyroid to concentrate iodide.	Iodides	131-137	solute carrier family 5 member 5	Homo sapiens	22-25
10875253-1	2000	Here, we studied the fragmentation of the prothyroid hormone, thyroglobulin (Tg), which occurs during thyroid hormone synthesis, a process which involves iodide, thyroperoxidase, and the H2O2-generating system, consisting of glucose and glucose oxidase.	Iodides	154-160	thyroglobulin	Homo sapiens	62-75
10893432-1	2000	The Na(+)/I(-) symporter (NIS) is an intrinsic membrane protein that mediates the active transport of iodide into the thyroid and other tissues, such as salivary glands, gastric mucosa, and lactating mammary gland.	Iodides	102-108	solute carrier family 5 member 5	Homo sapiens	4-24
10893432-1	2000	The Na(+)/I(-) symporter (NIS) is an intrinsic membrane protein that mediates the active transport of iodide into the thyroid and other tissues, such as salivary glands, gastric mucosa, and lactating mammary gland.	Iodides	102-108	solute carrier family 5 member 5	Homo sapiens	26-29
10893432-2	2000	NIS plays key roles in thyroid pathophysiology as the route by which iodide reaches the gland for thyroid hormone biosynthesis and as a means for diagnostic scintigraphic imaging and for radioiodide therapy in hyperthyroidism and thyroid cancer.	Iodides	69-75	solute carrier family 5 member 5	Homo sapiens	0-3
10893432-6	2000	In gene therapy experiments, the rat NIS gene has been transduced into various types of human cells, which then exhibited active iodide transport and became susceptible to destruction with radioiodide.	Iodides	129-135	solute carrier family 5 member 5	Rattus norvegicus	37-40
10907960-1	2000	Active iodide uptake across the basal membrane mediated by human sodium iodide symporter (hNIS) has been shown to be a process coupled with the flow of sodium.	Iodides	7-13	solute carrier family 5 member 5	Homo sapiens	90-94
10907960-5	2000	Thyroid and metastatic tissues were then obtained for this study, which is aimed at comparing the iodide trapping ability in vivo and in vitro of hNIS, and then comparing their expression in both thyroid tissue and metastatic tissues.	Iodides	98-104	solute carrier family 5 member 5	Homo sapiens	146-150
11227429-8	2000	The method has been applied to the determination of iodide in tap and sea waters.	Iodides	52-58	nuclear RNA export factor 1	Homo sapiens	62-65
10932223-4	2000	In addition to characterizing the hormonal regulation of the mammary gland sodium/iodide symporter, we demonstrate by scintigraphy that mammary adenocarcinomas in transgenic mice bearing Ras or Neu oncogenes actively accumulate iodide by this symporter in vivo.	Iodides	82-88	erb-b2 receptor tyrosine kinase 2	Mus musculus	194-197
10932223-4	2000	In addition to characterizing the hormonal regulation of the mammary gland sodium/iodide symporter, we demonstrate by scintigraphy that mammary adenocarcinomas in transgenic mice bearing Ras or Neu oncogenes actively accumulate iodide by this symporter in vivo.	Iodides	228-234	erb-b2 receptor tyrosine kinase 2	Mus musculus	194-197
10826917-3	2000	Iodide, bromide, thiocyanide and chloride effectively supplemented the MPO/H2O2 system, KI and NaCl being the most and the least effective supplements, respectively.	Iodides	0-6	myeloperoxidase	Sus scrofa	71-74
10861298-1	2000	The PDS gene encodes a transmembrane protein, known as pendrin, which functions as a transporter of iodide and chloride.	Iodides	100-106	solute carrier family 26 member 4	Homo sapiens	4-7
10861298-1	2000	The PDS gene encodes a transmembrane protein, known as pendrin, which functions as a transporter of iodide and chloride.	Iodides	100-106	solute carrier family 26 member 4	Homo sapiens	55-62
10861298-5	2000	The mutations associated with Pendred syndrome have complete loss of pendrin-induced chloride and iodide transport, while alleles unique to people with DFNB4 are able to transport both iodide and chloride, albeit at a much lower level than wild-type pendrin.	Iodides	185-191	solute carrier family 26 member 4	Homo sapiens	152-157
10861298-7	2000	We propose a model for pendrin function in the thyroid in which pendrin transports iodide across the apical membrane of the thyrocyte into the colloid space.	Iodides	83-89	solute carrier family 26 member 4	Homo sapiens	23-30
10861298-7	2000	We propose a model for pendrin function in the thyroid in which pendrin transports iodide across the apical membrane of the thyrocyte into the colloid space.	Iodides	83-89	solute carrier family 26 member 4	Homo sapiens	64-71
10902780-1	2000	Molecular cloning of the sodium/iodide symporter (NIS) allowed identification of NIS gene mutations in patients with iodide trapping defect.	Iodides	32-38	solute carrier family 5 member 5	Homo sapiens	50-53
10902780-1	2000	Molecular cloning of the sodium/iodide symporter (NIS) allowed identification of NIS gene mutations in patients with iodide trapping defect.	Iodides	32-38	solute carrier family 5 member 5	Homo sapiens	81-84
10843191-12	2000	Eight of the 11 (73%) GD and 3 of the 7 (43%) AH sera, which were positive for hNIS antibodies in the immunoprecipitation assay, were also found to inhibit iodide uptake in hNIS-transfected CHO-K1 cells, suggesting the existence of antibodies in some serum samples that bind to the symporter without modulating its function.	Iodides	156-162	solute carrier family 5 member 5	Homo sapiens	79-83
10843191-12	2000	Eight of the 11 (73%) GD and 3 of the 7 (43%) AH sera, which were positive for hNIS antibodies in the immunoprecipitation assay, were also found to inhibit iodide uptake in hNIS-transfected CHO-K1 cells, suggesting the existence of antibodies in some serum samples that bind to the symporter without modulating its function.	Iodides	156-162	solute carrier family 5 member 5	Homo sapiens	173-177
10843191-13	2000	Overall, a significant correlation was found between the iodide uptake inhibition and the binding assays for hNIS antibody detection (r = 0.49, P &lt; 0.0001).	Iodides	57-63	solute carrier family 5 member 5	Homo sapiens	109-113
10843192-2	2000	Its product, designated pendrin, was shown to transport chloride and iodide.	Iodides	69-75	solute carrier family 26 member 4	Homo sapiens	24-31
10782045-4	2000	Since prolactin stimulates iodide accumulation in milk, the goal of these studies was to determine the role of the polyamines in this hormone response.	Iodides	27-33	prolactin	Mus musculus	6-15
10782045-6	2000	In mammary gland explants from midpregnant (10-14 days of pregnancy) mice, MGBG at 100 microM abolished the prolactin stimulation of iodide uptake and incorporation into milk proteins, whereas DFMO caused a concentration-dependent inhibition of the PRL response.	Iodides	133-139	prolactin	Mus musculus	108-117
10782045-8	2000	These data suggest that the polyamine signaling pathway is involved in the prolactin stimulation of iodide uptake into milk.	Iodides	100-106	prolactin	Mus musculus	75-84
10770487-5	2000	Decreased MOD-1 and increased p50/p65 have been separately associated with the ability of autoregulatory (high) concentrations of iodide to suppress thyrocyte growth and function, as well as MHC class I expression.	Iodides	130-136	synaptotagmin 1	Rattus norvegicus	34-37
10707050-1	2000	The active transport of iodide into the thyroid is mediated by the Na(+)-I- symporter (NIS), an intrinsic membrane protein.	Iodides	24-30	solute carrier family 5 member 5	Rattus norvegicus	67-85
10770487-1	2000	Transforming growth factor (TGF)-beta1-decreased major histocompatibility complex (MHC) class I gene expression in thyrocytes is transcriptional; it involves trans factors and cis elements important for hormone- as well as iodide-regulated thyroid growth and function.	Iodides	223-229	transforming growth factor, beta 1	Rattus norvegicus	0-38
10770487-5	2000	Decreased MOD-1 and increased p50/p65 have been separately associated with the ability of autoregulatory (high) concentrations of iodide to suppress thyrocyte growth and function, as well as MHC class I expression.	Iodides	130-136	malic enzyme 1	Rattus norvegicus	10-15
10707050-1	2000	The active transport of iodide into the thyroid is mediated by the Na(+)-I- symporter (NIS), an intrinsic membrane protein.	Iodides	24-30	solute carrier family 5 member 5	Rattus norvegicus	87-90
10692330-10	2000	The iodide quenching results from calcium-activated FHS-myofibrils indicate that during isometric contraction 29% of the myosin heads are strongly bound to actin within the myofilament lattice at low ionic strength.	Iodides	4-10	myosin heavy chain 14	Homo sapiens	121-127
10704209-1	2000	Previous work has demonstrated that the ferric form of soybean lipoxygenase-1 will catalyze an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce 9, 11-octadecadienoic acid and iodide ion.	Iodides	203-209	linoleate 9S-lipoxygenase-4	Glycine max	63-75
10720070-1	2000	In the thyroid, active transport of iodide is under control of the TSH-dependent Na+/I- symporter (NIS), whereas in the breast such control is less well understood.	Iodides	36-42	solute carrier family 5 member 5	Homo sapiens	81-97
10719389-1	2000	Normal in vitro thyroid peroxidase (TPO) iodide oxidation activity was completely inhibited by a hydrolyzed TPO preparation (0.15 mg/ml) or hydrolyzed bovine serum albumin (BSA, 0.2 mg/ml).	Iodides	41-47	thyroid peroxidase	Homo sapiens	36-39
10719389-1	2000	Normal in vitro thyroid peroxidase (TPO) iodide oxidation activity was completely inhibited by a hydrolyzed TPO preparation (0.15 mg/ml) or hydrolyzed bovine serum albumin (BSA, 0.2 mg/ml).	Iodides	41-47	thyroid peroxidase	Homo sapiens	108-111
10719389-4	2000	The amino acids that impair iodide oxidation also inhibit the TPO albumin iodination activity.	Iodides	28-34	thyroid peroxidase	Homo sapiens	62-65
10779135-1	2000	The sodium iodide symporter (NIS) is a plasma membrane protein that is responsible for iodide transport into thyroid cells.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
10702801-7	2000	Expression of a Ras effector mutant (RasV12S35) that signals preferentially through Raf-1, although sufficient to confer TSH-independent proliferation, abolished hormone-regulated expression of thyroglobulin and the sodium/iodide symporter.	Iodides	223-229	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	84-89
10650967-9	2000	Together, these results suggest that pendrin is an apical porter of iodide in the thyroid and that the expression and function of both the apical and basal iodide porters are coordinately regulated by follicular TG.	Iodides	68-74	solute carrier family 26 member 4	Rattus norvegicus	37-44
10650940-0	2000	Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress.	Iodides	0-6	tumor protein p53	Homo sapiens	59-62
10650967-0	2000	Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells.	Iodides	88-94	solute carrier family 26 member 4	Rattus norvegicus	0-7
10606962-2	2000	We have used this model to examine the effect of iodide on TPO antibody induction as well as to analyse the interaction between T and B cells.	Iodides	49-55	thyroid peroxidase	Mus musculus	59-62
10650967-0	2000	Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells.	Iodides	88-94	solute carrier family 26 member 4	Rattus norvegicus	36-57
10650967-0	2000	Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells.	Iodides	88-94	solute carrier family 26 member 4	Rattus norvegicus	59-62
10718548-1	2000	Previously, we observed that excess iodide rapidly suppressed the elevated ornithine decarboxylase activity in the thyroid of propylthiouracil (PTU)-pretreated rats.	Iodides	36-42	ornithine decarboxylase 1	Rattus norvegicus	75-98
10718549-2	2000	The adenomas were characterized by a high level of iodide trapping that corresponds to a high level of Na+ /iodide symporter gene expression, a high thyroperoxidase mRNA and protein content, and a low H2O2 generation.	Iodides	51-57	thyroid peroxidase	Homo sapiens	149-164
10718550-6	2000	TBG probably facilitates the transport of maternal T4 and iodide to the fetus, although this remains to be proven.	Iodides	58-64	serpin family A member 7	Homo sapiens	0-3
10650940-2	2000	In this study, we investigated the effect of iodide excess in an immortalized thyroid cell line (TAD-2) in primary cultures of human thyroid cells and in cells of nonthyroid origin.	Iodides	45-51	adenosine deaminase tRNA specific 2	Homo sapiens	97-102
10650940-3	2000	Iodide displayed a dose-dependent cytotoxicity in both TAD-2 and primary thyroid cells, although at different concentrations, whereas it had no effect on cells of nonthyroid origin.	Iodides	0-6	adenosine deaminase tRNA specific 2	Homo sapiens	55-60
10497062-0	1999	Use of a chaotropic anion iodide in the purification of Z-line proteins: isolation of CapZ from fish white muscle.	Iodides	26-32	capping actin protein of muscle Z-line alpha subunit 2	Gallus gallus	86-90
10537174-0	1999	Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium/iodide symporter gene.	Iodides	36-42	thyroglobulin	Homo sapiens	11-24
10537174-0	1999	Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium/iodide symporter gene.	Iodides	90-96	thyroglobulin	Homo sapiens	11-24
10588823-1	1999	The recent cloning of the thyroidal protein that is responsible for iodide transport, the sodium iodide symporter (hNIS), has made possible studies designed to characterize its structure, function and expression in thyroidal tissues.	Iodides	68-74	solute carrier family 5 member 5	Homo sapiens	115-119
10564094-0	1999	Long-wavelength iodide-sensitive fluorescent indicators for measurement of functional CFTR expression in cells.	Iodides	16-22	CF transmembrane conductance regulator	Homo sapiens	86-90
10576759-1	1999	The recent cloning of the gene encoding the sodium/iodide symporter (NIS) has enabled better characterization of the molecular mechanisms underlying iodide transport, thus opening the way to clarifying its role in thyroid diseases.	Iodides	51-57	solute carrier family 5 member 5	Homo sapiens	69-72
10576759-2	1999	Several studies, at both the mRNA and the protein expression levels, have demonstrated that TSH, the primary regulator of iodide uptake, upregulates NIS gene expression and NIS protein abundance, both in vitro and in vivo.	Iodides	122-128	solute carrier family 5 member 5	Homo sapiens	149-152
10576759-3	1999	However, other factors, including iodide, retinoic acid, transforming growth factor-beta, interleukin-1alpha and tumour necrosis factor alpha, may participate in the regulation of NIS expression.	Iodides	34-40	solute carrier family 5 member 5	Homo sapiens	180-183
10566669-1	1999	The human sodium iodide symporter (hNIS) is an intrinsic transmembrane protein that mediates the active transport of iodide across the basolateral membrane of thyroid follicular cells.	Iodides	17-23	solute carrier family 5 member 5	Homo sapiens	35-39
10566669-8	1999	In conclusion, our study demonstrates the expression of hNIS protein by several human exocrine glands, suggesting that iodide transport in these glands is a specific property conferred by the expression of hNIS protein, which may serve important functions by concentrating iodine in glandular secretions.	Iodides	119-125	solute carrier family 5 member 5	Homo sapiens	56-60
10566669-8	1999	In conclusion, our study demonstrates the expression of hNIS protein by several human exocrine glands, suggesting that iodide transport in these glands is a specific property conferred by the expression of hNIS protein, which may serve important functions by concentrating iodine in glandular secretions.	Iodides	119-125	solute carrier family 5 member 5	Homo sapiens	206-210
10483259-9	1999	In conclusion, it is suggested that the incidence of the antibodies against NaIS is higher in Graves" disease than Hashimoto"s thyroiditis, and these antibodies inhibit iodide uptake.	Iodides	169-175	solute carrier family 5 member 5	Homo sapiens	76-80
10433193-10	1999	NIS mRNA was decreased at 6 and 24 h after acute iodide administration, whereas NIS protein was decreased only at 24 h. TPO mRNA was decreased at 6 days of chronic iodide ingestion and 24 h after acute iodide administration.	Iodides	164-170	thyroid peroxidase	Rattus norvegicus	120-123
10433193-10	1999	NIS mRNA was decreased at 6 and 24 h after acute iodide administration, whereas NIS protein was decreased only at 24 h. TPO mRNA was decreased at 6 days of chronic iodide ingestion and 24 h after acute iodide administration.	Iodides	164-170	thyroid peroxidase	Rattus norvegicus	120-123
10443704-1	1999	The thyroid sodium-iodide symporter (NIS) is responsible for iodide concentrating ability within thyroid follicular cells.	Iodides	19-25	solute carrier family 5 member 5	Homo sapiens	37-40
10488073-5	1999	Using the iodide efflux technique, we show that MPB compounds activate CFTR chloride channels in Chinese hamster ovary (CHO) cells stably expressing CFTR but not in CHO cells lacking CFTR.	Iodides	10-16	AFA1	Homo sapiens	48-51
10488073-5	1999	Using the iodide efflux technique, we show that MPB compounds activate CFTR chloride channels in Chinese hamster ovary (CHO) cells stably expressing CFTR but not in CHO cells lacking CFTR.	Iodides	10-16	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	71-75
10482376-12	1999	IL-6 did not alter NIS functional activity, but IL-1beta suppressed iodide accumulation by approximately 25%.	Iodides	68-74	interleukin 1 beta	Rattus norvegicus	48-56
10482376-1	1999	The sodium iodide symporter (NIS), first identified in FRTL-5 cells, plays a critical role in iodide transport in the thyroid gland and in the production of the iodine-containing thyroid hormones.	Iodides	11-17	solute carrier family 5 member 5	Rattus norvegicus	29-32
10482376-16	1999	In conclusion, our data suggest that various agents known to affect iodide transport are capable of differentially altering NIS gene expression and function in cultured thyroid cells.	Iodides	68-74	solute carrier family 5 member 5	Rattus norvegicus	124-127
10404820-0	1999	Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human Na+/I-symporter gene methylation status.	Iodides	15-21	solute carrier family 5 member 5	Homo sapiens	90-105
10447009-2	1999	In FRTL-5 rat thyroid cells, hCG increases cyclic adenosine monophosphate (cAMP), iodide transport, and cell growth.	Iodides	82-88	chorionic gonadotropin subunit beta 5	Homo sapiens	29-32
10447022-8	1999	Recent mutations have been described in the genes coding for the sodium/iodide symporter, thyroid peroxidase (TPO), and thyroglobulin.	Iodides	72-78	thyroid peroxidase	Homo sapiens	110-113
10366416-4	1999	In vivo results showed that the steady-state level of thymosin beta10 mRNA is up-regulated in the thyroid gland of propylthiouracil-fed rats in parallel with follicular cell proliferation: iodide administration to goitrous rats, which induced a marked involution of thyroid hyperplasia, reduced the mRNA level of thymosin beta10.	Iodides	189-195	thymosin, beta 10	Rattus norvegicus	54-69
10380889-8	1999	These findings provide a model for the role of RET/PTC1 in the formation of abnormal follicles with reduced iodide uptake ability observed in human papillary thyroid carcinoma.	Iodides	108-114	ret proto-oncogene	Homo sapiens	47-50
10380889-8	1999	These findings provide a model for the role of RET/PTC1 in the formation of abnormal follicles with reduced iodide uptake ability observed in human papillary thyroid carcinoma.	Iodides	108-114	patched 1	Homo sapiens	51-55
10403177-3	1999	A defect in the NIS (iodide trapping defect) can result in hypothyroidism, the severity of which is variable and influenced, in part, by the amount of iodine supply.	Iodides	21-27	solute carrier family 5 member 5	Homo sapiens	16-19
10403177-4	1999	The molecular cloning of NIS and characterization of its genomic organization allowed the identification of NIS gene mutations in patients expressing the phenotype of iodide trapping defect.	Iodides	167-173	solute carrier family 5 member 5	Homo sapiens	25-28
10403177-4	1999	The molecular cloning of NIS and characterization of its genomic organization allowed the identification of NIS gene mutations in patients expressing the phenotype of iodide trapping defect.	Iodides	167-173	solute carrier family 5 member 5	Homo sapiens	108-111
10232600-2	1999	Causing prostate cancer cells to express functionally active sodium iodide symporter (NIS) would enable those cells to concentrate iodide from plasma and might offer the ability to treat prostate cancer with radioiodine.	Iodides	68-74	solute carrier family 5 member 5	Homo sapiens	86-89
10232600-9	1999	Prostate cells transfected with NIS/PSA-pEGFP-1 showed perchlorate-sensitive, androgen-dependent iodide uptake in a range comparable to that observed in control cell lines transfected with hNIS cDNA.	Iodides	97-103	solute carrier family 5 member 5	Homo sapiens	32-35
10232600-13	1999	In conclusion, tissue-specific androgen-dependent iodide uptake activity has been induced in prostate cancer cells by PSA promoter-directed NIS expression.	Iodides	50-56	solute carrier family 5 member 5	Homo sapiens	140-143
10229912-3	1999	DESIGN AND METHODS: Expression of the NIS gene was investigated by Northern blot analysis in normal and in some oncogene-transformed cell lines with different degrees of malignancy which had lost the iodide uptake ability.	Iodides	200-206	solute carrier family 5 member 5	Rattus norvegicus	38-41
10229912-9	1999	CONCLUSIONS: Our data show that oncogene activation could play a role in affecting the iodide uptake ability in thyroid tumoral cells; different mechanisms are involved in the oncogene-dependent loss of NIS activity in transformed thyroid cells.	Iodides	87-93	solute carrier family 5 member 5	Rattus norvegicus	203-206
10355044-1	1999	Cloning, functional characterisation, and diagnostic proof of the expression of sodium-iodide-symporter (NIS) in the thyroid are essential steps for a better understanding of function and regulation of thyroid hormone synthesis, which is limited by the availability of the trace element iodide.	Iodides	87-93	solute carrier family 5 member 5	Homo sapiens	105-108
10365677-2	1999	Given the critical role of the Na+/I- symporter (NIS) in controlling iodide access to the thyroid gland, altered expression of NIS may be responsible, at least in part, for an enhanced or diminished capacity to concentrate iodide.	Iodides	69-75	solute carrier family 5 member 5	Homo sapiens	31-47
10365677-2	1999	Given the critical role of the Na+/I- symporter (NIS) in controlling iodide access to the thyroid gland, altered expression of NIS may be responsible, at least in part, for an enhanced or diminished capacity to concentrate iodide.	Iodides	69-75	solute carrier family 5 member 5	Homo sapiens	49-52
10365677-2	1999	Given the critical role of the Na+/I- symporter (NIS) in controlling iodide access to the thyroid gland, altered expression of NIS may be responsible, at least in part, for an enhanced or diminished capacity to concentrate iodide.	Iodides	223-229	solute carrier family 5 member 5	Homo sapiens	127-130
10192399-7	1999	The rates of transport for iodide and chloride were significantly increased following the expression of pendrin in both cell systems.	Iodides	27-33	solute carrier family 26 member 4	Homo sapiens	104-111
10192399-8	1999	Our results demonstrate that pendrin functions as a transporter of chloride and iodide, but not sulfate, and may provide insight into thyroid physiology and the pathophysiology of Pendred syndrome.	Iodides	80-86	solute carrier family 26 member 4	Homo sapiens	29-36
10319949-1	1999	The sodium iodide symporter (NIS) is the plasma membrane protein that mediates active iodide uptake into thyroid follicular cells.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32
10355044-4	1999	Experimental protocols aiming at the functional expression of NIS in thyroid tumors or their metastases which lost capability for iodide uptake are currently developed.	Iodides	130-136	solute carrier family 5 member 5	Homo sapiens	62-65
10355044-5	1999	Furthermore, techniques are under investigation to express functional NIS by gene transfer in those benign or malignant tissues, tumors, metastases, which normally do not accumulate iodide.	Iodides	182-188	solute carrier family 5 member 5	Homo sapiens	70-73
18967505-0	1999	Design of Schiff base complexes of Co(II) for the preparation of iodide-selective polymeric membrane electrodes.	Iodides	65-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
9973215-2	1999	The rat sodium/iodide symporter gene (rNIS) was cloned into a retroviral vector for transfer into cancer cells to mimic the iodide uptake of thyroid follicular cells.	Iodides	15-21	solute carrier family 5 member 5	Rattus norvegicus	38-42
9973215-3	1999	In vitro iodide transport shows that the symporter functions similarly in rNIS-transduced tumor cells and rat thyroid follicular cells.	Iodides	9-15	solute carrier family 5 member 5	Rattus norvegicus	74-78
10193578-3	1999	Chloride, iodide, bromide, and the thiocyanate anions were effective complements of the MPO/H2O2 system.	Iodides	10-16	myeloperoxidase	Equus caballus	88-91
10571950-3	1999	The disease gene (PDS) has been mapped to chromosome 7q22-q31, and encodes a chloride-iodide transport protein.	Iodides	86-92	solute carrier family 26 member 4	Homo sapiens	18-21
9924196-0	1999	A novel mutation in the human thyroid peroxidase gene resulting in a total iodide organification defect.	Iodides	75-81	thyroid peroxidase	Homo sapiens	30-48
9924196-1	1999	In this study we describe a novel mutation of the thyroid peroxidase (TPO) gene that resulted in a total iodide organification defect.	Iodides	105-111	thyroid peroxidase	Homo sapiens	50-68
9924196-1	1999	In this study we describe a novel mutation of the thyroid peroxidase (TPO) gene that resulted in a total iodide organification defect.	Iodides	105-111	thyroid peroxidase	Homo sapiens	70-73
9924196-6	1999	The latter mutation has already been reported as one of the mutations of the TPO gene resulting in total iodide organification defect.	Iodides	105-111	thyroid peroxidase	Homo sapiens	77-80
9924196-9	1999	The two mutations of the TPO gene resulting in the total iodide organification defect in the patient cosegregated from her parents.	Iodides	57-63	thyroid peroxidase	Homo sapiens	25-28
9922160-0	1998	Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate.	Iodides	63-69	myeloperoxidase	Homo sapiens	12-27
10821536-4	1999	While the TRK-T1 oncogene interferes with the capability of thyroid cells of trapping iodide and only marginally affects thyroglobulin gene expression, both RET/PTC3 and N-ras(Gln61-Lys) induce a dramatic reduction of thyroglobulin mRNA and alleviate TSH dependency for cellular growth.	Iodides	86-92	neurotrophic receptor tyrosine kinase 1	Homo sapiens	10-13
9922160-9	1998	SCN- is shown to be most effective in shifting the system myeloperoxidase/hydrogen peroxide from the peroxidatic cycle to the halogenation cycle, whereas iodide is shown to be more effective than bromide which in turn is much more effective than chloride.	Iodides	154-160	myeloperoxidase	Homo sapiens	58-73
9876351-1	1998	OBJECTIVE: Iodide uptake by the thyroid gland is mediated by the sodium iodide symporter (NIS).	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	90-93
9849820-0	1998	Increased expression of tumor necrosis factor-alpha and decreased expression of thyroglobulin and thyroid peroxidase mRNA levels in the thyroids of iodide-treated BB/Wor rats.	Iodides	148-154	tumor necrosis factor	Rattus norvegicus	24-51
9849820-0	1998	Increased expression of tumor necrosis factor-alpha and decreased expression of thyroglobulin and thyroid peroxidase mRNA levels in the thyroids of iodide-treated BB/Wor rats.	Iodides	148-154	thyroglobulin	Rattus norvegicus	80-93
9849820-9	1998	In rats treated with iodide for 1 month, there was a modest decrease in Tg and TPO mRNA levels in follicular cells in contact with infiltrating mononuclear cells.	Iodides	21-27	thyroid peroxidase	Rattus norvegicus	79-82
9849820-10	1998	After 2 months of iodide treatment there was clearly a localized decrease in Tg and TPO mRNA levels in follicular cells in contact with infiltrating mononuclear cells.	Iodides	18-24	thyroid peroxidase	Rattus norvegicus	84-87
9769419-4	1998	The protein kinase C (PKC) activator, phorbol dibutyrate, enhanced cAMP-stimulated iodide efflux.	Iodides	83-89	proline rich transmembrane protein 2	Homo sapiens	22-25
9814499-1	1998	Antipeptide antibodies raised against the carboxyl-terminal region of the human sodium/iodide (Na+/I-) symporter (hNIS) were used to investigate by immunohistochemistry the presence and distribution of the hNIS protein in normal thyroid tissues, in some pathological nonneoplastic thyroid tissues, and in different histotypes of thyroid neoplasms.	Iodides	87-93	solute carrier family 5 member 5	Homo sapiens	95-112
9814499-1	1998	Antipeptide antibodies raised against the carboxyl-terminal region of the human sodium/iodide (Na+/I-) symporter (hNIS) were used to investigate by immunohistochemistry the presence and distribution of the hNIS protein in normal thyroid tissues, in some pathological nonneoplastic thyroid tissues, and in different histotypes of thyroid neoplasms.	Iodides	87-93	solute carrier family 5 member 5	Homo sapiens	114-118
9814499-12	1998	As hNIS expression appears to be related to TSHR stimulation, the decreased number of TSHR-positive cells in cancers may contribute to the reduced capacity of neoplastic cells to concentrate iodide.	Iodides	191-197	thyroid stimulating hormone receptor	Homo sapiens	86-90
9790174-0	1998	Possible involvement of P13K in prolactin-stimulated milk product formation and iodide transport in mouse mammary explants.	Iodides	80-86	prolactin	Mus musculus	32-41
9790174-1	1998	The in vitro effect of wortmannin, an inhibitor of P13 kinase, on prolactin (PRL) stimulated p70S6K, iodide transport, and milk product synthesis were investigated in cultured mouse mammary tissues.	Iodides	101-107	prolactin	Mus musculus	66-75
9790174-4	1998	Rapamycin (25 ng/ml), an inhibitor of p70S6K, also inhibited the effect of PRL on iodide transport; this drug was earlier shown to inhibit PRL effects on milk product synthesis.	Iodides	82-88	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	38-44
9790174-5	1998	These results suggest the possible involvement of p70S6K and P13-kinase in PRL-stimulated milk product formation and iodide transport in mouse mammary explants.	Iodides	117-123	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	50-56
9876351-8	1998	IL-1 alpha, TNF alpha and IFN gamma at concentrations of 10(5) U/l all inhibited TSH-induced NIS gene expression and iodide uptake.	Iodides	117-123	interleukin 1 alpha	Homo sapiens	0-10
9751526-1	1998	The human Na+/I- symporter (hNIS) is the plasma membrane protein that mediates active iodide uptake into several tissues, such as the thyroid and salivary glands.	Iodides	86-92	solute carrier family 5 member 5	Homo sapiens	10-26
9751526-1	1998	The human Na+/I- symporter (hNIS) is the plasma membrane protein that mediates active iodide uptake into several tissues, such as the thyroid and salivary glands.	Iodides	86-92	solute carrier family 5 member 5	Homo sapiens	28-32
9751510-2	1998	Human thyroperoxidase (hTPO), a type I transmembrane heme containing glycoprotein, catalyzes iodide organification and thyroid hormone synthesis and plays a major role in thyroid autoimmunity.	Iodides	93-99	thyroid peroxidase	Homo sapiens	6-21
9876351-8	1998	IL-1 alpha, TNF alpha and IFN gamma at concentrations of 10(5) U/l all inhibited TSH-induced NIS gene expression and iodide uptake.	Iodides	117-123	tumor necrosis factor	Homo sapiens	12-21
9751510-2	1998	Human thyroperoxidase (hTPO), a type I transmembrane heme containing glycoprotein, catalyzes iodide organification and thyroid hormone synthesis and plays a major role in thyroid autoimmunity.	Iodides	93-99	thyroid peroxidase	Homo sapiens	23-27
9876351-8	1998	IL-1 alpha, TNF alpha and IFN gamma at concentrations of 10(5) U/l all inhibited TSH-induced NIS gene expression and iodide uptake.	Iodides	117-123	interferon gamma	Homo sapiens	26-35
9876351-9	1998	In these experiments, there was a good correlation between NIS mRNA expression and iodide uptake.	Iodides	83-89	solute carrier family 5 member 5	Homo sapiens	59-62
9806481-6	1998	Sodium dependent iodide symporter (NIS) actively transports iodide into the thyroid cells to produce thyroid hormones.	Iodides	17-23	solute carrier family 5 member 5	Homo sapiens	35-38
9745437-1	1998	The Na+/I- symporter (NIS) is the plasma membrane protein that mediates active iodide uptake into thyroid follicular cells.	Iodides	79-85	solute carrier family 5 member 5	Homo sapiens	4-20
9745437-1	1998	The Na+/I- symporter (NIS) is the plasma membrane protein that mediates active iodide uptake into thyroid follicular cells.	Iodides	79-85	solute carrier family 5 member 5	Homo sapiens	22-25
9846164-1	1998	Iodide concentration by the thyroid gland, an essential step for thyroid hormone synthesis, is mediated by the Na+/I- symporter (NIS).	Iodides	0-6	solute carrier family 5 member 5	Rattus norvegicus	111-127
9846164-1	1998	Iodide concentration by the thyroid gland, an essential step for thyroid hormone synthesis, is mediated by the Na+/I- symporter (NIS).	Iodides	0-6	solute carrier family 5 member 5	Rattus norvegicus	129-132
9745458-5	1998	The NIS mutants carrying these mutations had minimal iodide uptake activity when expressed in COS-7 cells, confirming that the identified mutations are the direct cause of the iodide transport defect in these patients.	Iodides	53-59	solute carrier family 5 member 5	Homo sapiens	4-7
9745458-6	1998	Genotyping of unaffected family members and functional assays of co-transfected COS-7 cells indicate that expression of one normal NIS allele in the heterozygote (T354P, G93R, or G543E) is sufficient to maintain active iodide uptake activity.	Iodides	219-225	solute carrier family 5 member 5	Homo sapiens	131-134
9801997-4	1998	The persistent 131I retention, another cause of "spurious metastasis", may have occurred because of protein binding of iodide carried out by salivary peroxidase.	Iodides	119-125	lactoperoxidase	Homo sapiens	141-160
9635142-5	1998	Substitution of iodide or sulfate for trans chloride, slowed SCN- uptake by 4-fold and 35-fold respectively.	Iodides	16-22	sorcin	Homo sapiens	61-64
9698945-3	1998	Quenching studies demonstrated that Trp 6 and Trp 113 are "buried" to acrylamide, iodide ions and caesium ions.	Iodides	82-88	transient receptor potential cation channel subfamily C member 6	Homo sapiens	36-41
9543144-1	1998	The transport of iodide into the thyroid, catalyzed by the Na+/I- symporter (NIS), is the initial and rate-limiting step in the formation of thyroid hormones.	Iodides	17-23	solute carrier family 5 member 5	Homo sapiens	59-75
9607947-5	1998	However, adsorption of rIL-2 to liposomes alters this situation dramatically- fluorescence intensity increased 2-fold and the residue became more susceptible to iodide quenching.	Iodides	161-167	interleukin 2	Rattus norvegicus	23-28
9525971-2	1998	The Na+/I- symporter (NIS) is primarily responsible for the uptake of iodide into thyroid cells.	Iodides	70-76	solute carrier family 5 member 5	Homo sapiens	4-20
9525971-2	1998	The Na+/I- symporter (NIS) is primarily responsible for the uptake of iodide into thyroid cells.	Iodides	70-76	solute carrier family 5 member 5	Homo sapiens	22-25
9605935-1	1998	The stimulation of iodide (I-) transport by TSH in FRTL-5 thyroid cells is partly due to an increase in Na+/I- symporter (NIS) gene expression.	Iodides	19-25	solute carrier family 5 member 5	Rattus norvegicus	104-120
9672241-1	1998	The Na+/I- symporter (NIS) catalyzes the accumulation of iodide into thyroid cells, an essential step in the biosynthesis of thyroid hormones.	Iodides	57-63	solute carrier family 5 member 5	Homo sapiens	4-20
9672241-1	1998	The Na+/I- symporter (NIS) catalyzes the accumulation of iodide into thyroid cells, an essential step in the biosynthesis of thyroid hormones.	Iodides	57-63	solute carrier family 5 member 5	Homo sapiens	22-25
9543144-1	1998	The transport of iodide into the thyroid, catalyzed by the Na+/I- symporter (NIS), is the initial and rate-limiting step in the formation of thyroid hormones.	Iodides	17-23	solute carrier family 5 member 5	Homo sapiens	77-80
9543144-3	1998	In agreement with previous work on the rat NIS, iodide uptake in these cells was initiated within 2 min of the addition of 131I, reaching a plateau after 30 min.	Iodides	48-54	solute carrier family 5 member 5	Rattus norvegicus	43-46
9543144-10	1998	In summary, we have established a CHO cell line stably expressing the hNIS and shown that antibodies in GD sera can inhibit iodide uptake in these cells.	Iodides	124-130	solute carrier family 5 member 5	Homo sapiens	70-74
9686152-1	1998	Previous studies have shown that in vitro thyroid peroxidase (TPO) iodide oxidation activity is decreased and thyroid T4-5"-deiodinase activity is increased 15 days after induction of experimental diabetes mellitus (DM).	Iodides	67-73	thyroid peroxidase	Rattus norvegicus	62-65
9517388-2	1998	On the basis of their structure, we compared the ability of 35 xanthine derivatives to activate the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel stably expressed in chinese hamster ovary (CHO) cells using the cell-attached patch clamp and iodide efflux techniques.	Iodides	270-276	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	100-151
9517388-2	1998	On the basis of their structure, we compared the ability of 35 xanthine derivatives to activate the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel stably expressed in chinese hamster ovary (CHO) cells using the cell-attached patch clamp and iodide efflux techniques.	Iodides	270-276	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	153-157
9549759-1	1998	Perchlorate competitively blocks iodide from entering the thyroid by an effect on the Na+/I- symporter thus preventing the further synthesis of thyroid hormone but has no effect on the iodination process itself.	Iodides	33-39	solute carrier family 5 member 5	Homo sapiens	86-102
9449630-9	1998	After injection of oocytes with copy RNA coding for rat type I iodothyronine deiodinase, we found an increase in iodide production from rT3 from 2.3% (water-injected oocytes) to 46.2% accompanied by a reciprocal decrease in rT3 sulfate accumulation from 53.7% to 7.1%.	Iodides	113-119	iodothyronine deiodinase 1	Rattus norvegicus	56-87
9449644-3	1998	Thyroid follicular cells transport iodide from blood into the follicular lumen against an iodide gradient by means of coupled transport of Na+ ions and I- ions via the Na+/I- symporter (NIS).	Iodides	35-41	solute carrier family 5 member 5	Rattus norvegicus	168-184
9449644-1	1998	Iodide uptake, which is necessary for thyroid hormone synthesis, can be inhibited by aging, withdrawal of TSH, or increased tumor necrosis factor (TNF) and transforming growth factor (TGF)-beta1 levels resulting from the nonthyroid illness syndrome.	Iodides	0-6	tumor necrosis factor-like	Rattus norvegicus	124-145
9449644-1	1998	Iodide uptake, which is necessary for thyroid hormone synthesis, can be inhibited by aging, withdrawal of TSH, or increased tumor necrosis factor (TNF) and transforming growth factor (TGF)-beta1 levels resulting from the nonthyroid illness syndrome.	Iodides	0-6	tumor necrosis factor-like	Rattus norvegicus	147-150
9449644-3	1998	Thyroid follicular cells transport iodide from blood into the follicular lumen against an iodide gradient by means of coupled transport of Na+ ions and I- ions via the Na+/I- symporter (NIS).	Iodides	90-96	solute carrier family 5 member 5	Rattus norvegicus	168-184
9865544-1	1998	The recently cloned sodium-iodide symporter (NIS) represents a key molecule for thyroid function by efficiently accumulating iodide from the circulation into the thyrocyte against an electrochemical gradient.	Iodides	27-33	solute carrier family 5 member 5	Homo sapiens	45-48
9449644-13	1998	We conclude that 1) the decline in iodide uptake due to aging, a fall in serum TSH or an increase in TNF or TGF-beta1 is mediated primarily by a reduction in thyroid NIS expression; and 2) that receptor-mediated activation of sphingomyelinase is an important, protein synthesis-dependent, intracellular pathway for inhibition of NIS expression by TNF.	Iodides	35-41	transforming growth factor, beta 1	Rattus norvegicus	108-117
9449644-13	1998	We conclude that 1) the decline in iodide uptake due to aging, a fall in serum TSH or an increase in TNF or TGF-beta1 is mediated primarily by a reduction in thyroid NIS expression; and 2) that receptor-mediated activation of sphingomyelinase is an important, protein synthesis-dependent, intracellular pathway for inhibition of NIS expression by TNF.	Iodides	35-41	tumor necrosis factor-like	Rattus norvegicus	347-350
9428802-6	1998	High concentrations of iodide (1-50 microM, added daily) decreased the level of TPO.	Iodides	23-29	thyroid peroxidase	Homo sapiens	80-83
9449644-1	1998	Iodide uptake, which is necessary for thyroid hormone synthesis, can be inhibited by aging, withdrawal of TSH, or increased tumor necrosis factor (TNF) and transforming growth factor (TGF)-beta1 levels resulting from the nonthyroid illness syndrome.	Iodides	0-6	transforming growth factor, beta 1	Rattus norvegicus	156-194
9398703-2	1997	Twelve clones produced stimulating TSHRAbs that increased cAMP levels and iodide uptake in rat FRTL-5 thyroid cells and increased cAMP levels in Chinese hamster ovary (CHO) cells transfected with the human TSHR; like 95% of Graves" stimulating TSHRAbs, all 12 have their functional epitope on the N-terminus of the TSHR extracellular domain, requiring residues 90-165 for activity.	Iodides	74-80	thyroid stimulating hormone receptor	Homo sapiens	35-39
9440807-5	1998	Thus, iodide decreases the formation of Mod-1, an enhancer A complex involving the p50 subunit of NF-kappa B and a c-fos family member, fra-2, which was previously shown to be important in the suppression of class I levels by hydrocortisone.	Iodides	6-12	malic enzyme 1	Rattus norvegicus	40-45
9440807-5	1998	Thus, iodide decreases the formation of Mod-1, an enhancer A complex involving the p50 subunit of NF-kappa B and a c-fos family member, fra-2, which was previously shown to be important in the suppression of class I levels by hydrocortisone.	Iodides	6-12	FOS like 2, AP-1 transcription factor subunit	Rattus norvegicus	136-141
9440807-6	1998	Unlike hydrocortisone, iodide also increases the formation of a complex with enhancer A, which we show, in antibody shift experiments, is a heterodimer of the p50 and p65 subunits of NF-kappa B.	Iodides	23-29	synaptotagmin 1	Rattus norvegicus	167-170
9440807-9	1998	Second, the effect of iodide on class I RNA levels and on enhancer A complex formation with Mod-1 and the p50/p65 heterodimer is inhibited by agents that block the inositol phosphate, Ca++, phospholipase A2, arachidonate signal transduction pathway: acetylsalicylate, indomethacin, and 5,8,11,14-eicosatetraynoic acid.	Iodides	22-28	malic enzyme 1	Rattus norvegicus	92-97
9440807-9	1998	Second, the effect of iodide on class I RNA levels and on enhancer A complex formation with Mod-1 and the p50/p65 heterodimer is inhibited by agents that block the inositol phosphate, Ca++, phospholipase A2, arachidonate signal transduction pathway: acetylsalicylate, indomethacin, and 5,8,11,14-eicosatetraynoic acid.	Iodides	22-28	synaptotagmin 1	Rattus norvegicus	110-113
9440807-9	1998	Second, the effect of iodide on class I RNA levels and on enhancer A complex formation with Mod-1 and the p50/p65 heterodimer is inhibited by agents that block the inositol phosphate, Ca++, phospholipase A2, arachidonate signal transduction pathway: acetylsalicylate, indomethacin, and 5,8,11,14-eicosatetraynoic acid.	Iodides	22-28	phospholipase A2 group IB	Rattus norvegicus	190-206
9440807-10	1998	Interestingly, iodide can also decrease formation of the Mod-1 complex and increase formation of the complex with the p50/p65 subunits of NF-kappa B when the NF-kappa B enhancer sequence from the Ig kappa light chain, rather than enhancer A, is used as probe; and both actions mimic the action of a phorbol ester.	Iodides	15-21	malic enzyme 1	Rattus norvegicus	57-62
9440807-10	1998	Interestingly, iodide can also decrease formation of the Mod-1 complex and increase formation of the complex with the p50/p65 subunits of NF-kappa B when the NF-kappa B enhancer sequence from the Ig kappa light chain, rather than enhancer A, is used as probe; and both actions mimic the action of a phorbol ester.	Iodides	15-21	synaptotagmin 1	Rattus norvegicus	122-125
9398290-4	1997	Comparison of the accessibility of the three lifetime classes to the fluorescence quenchers acrylamide and iodide with the computed solvent accessibility of the three Trp residues in the crystal structure of NE indicates that the main, if not the sole, contribution to the 2.28 ns lifetime class is brought about by the fully buried Trp 141 residue.	Iodides	107-113	elastase, neutrophil expressed	Homo sapiens	208-210
9390185-2	1997	Here, we study the accessibility of the fluorescein covalently attached to the Lys515 at the nucleotide binding domain of the ATPase to the small collisional quencher iodide at pH 6 and 8, as well as the effect of ligand binding (La3+, La(3+)-nucleotide, and Ca2+).	Iodides	167-173	dynein axonemal heavy chain 8	Homo sapiens	126-132
9492156-1	1998	Elucidation of the regulation of human sodium-iodide symporter (hNIS) gene expression is critical to understanding its effects on iodide concentration abilities of thyroid and thyroid carcinomas.	Iodides	46-52	solute carrier family 5 member 5	Homo sapiens	64-68
9492157-4	1998	TPO activity in each of the fetal stages was higher than in the adult; a marked increase was observed in stages IV and V. Iodide transport (T/M) was similar in stages I to V and the adult.	Iodides	122-128	LOW QUALITY PROTEIN: thyroid peroxidase	Bos taurus	0-3
9464451-6	1997	In the presence of iodide ion, genistein and daidzein blocked TPO-catalyzed tyrosine iodination by acting as alternate substrates, yielding mono-, di-, and triiodoisoflavones.	Iodides	19-25	thyroid peroxidase	Homo sapiens	62-65
9349585-1	1997	Highly purified human chorionic gonadotropin (hCG) interacts with the thyrotropin (TSH) receptor and stimulates triiodothyronine (T3) secretion, iodide uptake and organification, and cyclic adenosine monophosphate (cAMP) formation in human thyroid follicles.	Iodides	145-151	thyroid stimulating hormone receptor	Homo sapiens	22-96
9359420-1	1997	The neutrophil enzyme myeloperoxidase uses H2O2 to oxidize chloride, bromide, iodide and thiocyanate to their respective hypohalous acids.	Iodides	78-84	myeloperoxidase	Homo sapiens	22-37
9345265-1	1997	The Na+/I- symporter is the molecule that mediates active iodide uptake in the thyroid gland.	Iodides	58-64	solute carrier family 5 member 5	Rattus norvegicus	4-20
9322970-0	1997	Iodide uptake and experimental 131I therapy in transplanted undifferentiated thyroid cancer cells expressing the Na+/I- symporter gene.	Iodides	0-6	solute carrier family 5 member 5	Rattus norvegicus	113-129
9349586-8	1997	As predicted, TGFbeta1 inhibited TSH-stimulated iodide uptake activity.	Iodides	48-54	transforming growth factor, beta 1	Rattus norvegicus	14-22
9349586-9	1997	These results suggest that the inhibitory effect of TGFbeta1 on TSH-stimulated iodide uptake is at least in part due to a suppression of NIS specific transcription.	Iodides	79-85	transforming growth factor, beta 1	Rattus norvegicus	52-60
9349585-5	1997	Desialylated (ds)-hCG and deglycosylated (dg)-hCG dose-dependently stimulated T3 secretion, iodide uptake and organification, and in each case did so with about twice the intrinsic activity of native hCG.	Iodides	92-98	chorionic gonadotropin subunit beta 5	Homo sapiens	18-21
9349585-5	1997	Desialylated (ds)-hCG and deglycosylated (dg)-hCG dose-dependently stimulated T3 secretion, iodide uptake and organification, and in each case did so with about twice the intrinsic activity of native hCG.	Iodides	92-98	chorionic gonadotropin subunit beta 5	Homo sapiens	46-49
9349585-5	1997	Desialylated (ds)-hCG and deglycosylated (dg)-hCG dose-dependently stimulated T3 secretion, iodide uptake and organification, and in each case did so with about twice the intrinsic activity of native hCG.	Iodides	92-98	chorionic gonadotropin subunit beta 5	Homo sapiens	46-49
9349585-6	1997	Indeed, removal of the sialic acid or carbohydrate residues from native hCG transformed it into a thyroid stimulator that elicited a maximal response in terms of iodide uptake, organification and T3 secretion by human thyroid follicles as high as TSH and almost twice as high as native hCG.	Iodides	162-168	chorionic gonadotropin subunit beta 5	Homo sapiens	72-75
9305991-4	1997	When properly processed mutants were evaluated for functional defects by the iodide efflux method, the G178R- and E193K-CFTR-expressing cell lines showed impaired anion translocation activities.	Iodides	77-83	CF transmembrane conductance regulator	Homo sapiens	120-124
9349586-1	1997	Iodide transport into the thyroid catalyzed by the Na+/I- symporter (NIS), is the first and main rate-limiting step in thyroid hormone synthesis.	Iodides	0-6	solute carrier family 5 member 5	Rattus norvegicus	51-67
9349586-3	1997	Although transforming growth factor-beta1 (TGFbeta1) is known to affect thyroid cell function, it is still unclear how TGFbeta1 regulates TSH-stimulated iodide accumulation.	Iodides	153-159	transforming growth factor, beta 1	Rattus norvegicus	119-127
9296378-0	1997	Moderate doses of iodide in vivo inhibit cell proliferation and the expression of thyroperoxidase and Na+/I- symporter mRNAs in dog thyroid.	Iodides	18-24	thyroid peroxidase	Canis lupus familiaris	82-97
9316456-3	1997	In the present study, we found that TNF-alpha inhibits TSH-induced H2O2 production, which is an inevitable process for iodide organification, and hence thyroid hormone synthesis, in FRTL-5 thyroid cells.	Iodides	119-125	tumor necrosis factor	Rattus norvegicus	36-45
9270719-0	1997	Characteristics of the prolactin stimulation of iodide uptake into mouse mammary gland explants.	Iodides	48-54	prolactin	Mus musculus	23-32
9270719-1	1997	We have recently reported that prolactin (PRL) stimulates iodide uptake into cultured mouse mammary tissues.	Iodides	58-64	prolactin	Mus musculus	31-40
9270719-1	1997	We have recently reported that prolactin (PRL) stimulates iodide uptake into cultured mouse mammary tissues.	Iodides	58-64	prolactin	Mus musculus	42-45
9270719-3	1997	The effect of PRL apparently involves an RNA-DNA-dependent mechanism, since actinomycin D and cyclohexamide abolish the PRL stimulation of iodide uptake and its incorporation into protein.	Iodides	139-145	prolactin	Mus musculus	14-17
9270719-3	1997	The effect of PRL apparently involves an RNA-DNA-dependent mechanism, since actinomycin D and cyclohexamide abolish the PRL stimulation of iodide uptake and its incorporation into protein.	Iodides	139-145	prolactin	Mus musculus	120-123
9270719-4	1997	Perchlorate and thiocyanate, inhibitors of the iodide transporter, also abolish the PRL effects on iodide uptake and incorporation.	Iodides	47-53	prolactin	Mus musculus	84-87
9270719-8	1997	The fact that both iodide transporter inhibitors and peroxidase inhibitors abolish PRL-stimulated iodide uptake and incorporation suggests that there may be a coupled mechanism involving the iodide transporter and the peroxidase enzyme.	Iodides	19-25	prolactin	Mus musculus	83-86
9296378-12	1997	TPO and NIS are therefore the only of these four genes whose expression is acutely modulated by iodide in vivo.	Iodides	96-102	thyroid peroxidase	Canis lupus familiaris	0-3
9296378-13	1997	Under TSH stimulation low doses of iodide resulted in: (1) decreased cell proliferation, (2) reestablished synthesis and secretion of thyroid hormones, (3) diminished TPO and NIS mRNA expression.	Iodides	35-41	thyroid peroxidase	Canis lupus familiaris	167-170
9231811-1	1997	The active iodide uptake of the thyroid gland in humans is mediated by the human sodium iodide symporter (hNIS).	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	106-110
9078271-7	1997	Iodide efflux measurements indicate that CFTR expression confers a plasma membrane anion conductance that is responsive to stimulation by cAMP.	Iodides	0-6	CF transmembrane conductance regulator	Canis lupus familiaris	41-45
9310864-2	1997	This method is based on the change of accessibility of 2-(12-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)amino)dodecanoyl-1-hexadecanoyl-sn-glycero-3- phosphatidyl-choline (NBD-PC), a membrane-buried fluorophore, to iodide, a quencher in the aqueous solution, during the phase transition.	Iodides	208-214	OXA1L mitochondrial inner membrane protein	Homo sapiens	76-81
9142647-4	1997	One prominent effect of TNF-alpha (and TGF-beta 1) on FRTL-5 cell function is suppression of iodide uptake, which is markedly stimulated by TSH.	Iodides	93-99	tumor necrosis factor	Rattus norvegicus	24-33
9142647-4	1997	One prominent effect of TNF-alpha (and TGF-beta 1) on FRTL-5 cell function is suppression of iodide uptake, which is markedly stimulated by TSH.	Iodides	93-99	transforming growth factor, beta 1	Rattus norvegicus	39-49
9142647-6	1997	Na+/K(+)-ATPase activity, which drives iodide uptake by thyroid cells, is inhibited by TNF-alpha and TGF-beta.	Iodides	39-45	tumor necrosis factor	Rattus norvegicus	87-96
9142647-6	1997	Na+/K(+)-ATPase activity, which drives iodide uptake by thyroid cells, is inhibited by TNF-alpha and TGF-beta.	Iodides	39-45	transforming growth factor, beta 1	Rattus norvegicus	101-109
9122265-6	1997	Voltage-dependent blocks by intracellular and extracellular iodide help to distinguish two distinct ion binding sites within the hClC-1 conduction pathway.	Iodides	60-66	chloride voltage-gated channel 1	Homo sapiens	129-135
9292955-8	1997	This increase of TGF beta 1 mRNA was slightly decreased by simultaneous incubation with delta-iodolactone (1 microM) or iodide (40 microM KI).	Iodides	120-126	transforming growth factor beta 1	Homo sapiens	17-27
9292955-9	1997	In contrast, both TSH (1 mU/mL) and forskolin (16 microM) decreased TGF beta 1 mRNA expression to about 70%, and this effect was abolished when follicles were pretreated with iodide (40 microM KI) in a concentration known to inhibit TSH action on cyclic adenosine monophosphate (cAMP) formation and proliferation.	Iodides	175-181	transforming growth factor beta 1	Homo sapiens	68-78
9078271-8	1997	The cAMP-stimulated iodide release is sensitive to glybenclamide, diphenylamine carboxylic acid and 5-nitro-2-(3-phenylpropylamino)benzoic acid, but not to 4,4"-di-isothiocyanostilbene-2,2"-disulphonic acid, an inhibitor profile characteristic of the CFTR chloride channel.	Iodides	20-26	CF transmembrane conductance regulator	Canis lupus familiaris	251-255
9078271-9	1997	Finally, the polarized localization of the CFTR to the apical plasma membrane was established by iodide efflux measurements and cell-surface biotinylation on MDCK I monolayers.	Iodides	97-103	CF transmembrane conductance regulator	Canis lupus familiaris	43-47
9024270-0	1997	Molecular analysis of mutated thyroid peroxidase detected in patients with total iodide organification defects.	Iodides	81-87	thyroid peroxidase	Homo sapiens	30-48
9006906-2	1997	Since members of this family of proteins such as P-glycoprotein and cystic fibrosis transmembrane conductance regulator share the ability to transport anions, we have investigated the transport capability of ABC1 expressed in Xenopus oocytes using iodide efflux and voltage-clamp techniques.	Iodides	248-254	ATP binding cassette subfamily A member 1 S homeolog	Xenopus laevis	208-212
9086575-6	1997	OSM inhibited iodide uptake stimulated by TSH; while IL-6 also inhibited iodide uptake, it was only about one-tenth as potent.	Iodides	73-79	interleukin 6	Homo sapiens	53-57